In JoVE (1)
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Articles by William J. Comstock in JoVE
The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections William J. Comstock1, Edwin Huh2, Reiley Weekes2, Connor Watson2, Tianyang Xu2, Pieter C. Dorrestein1, Robert A. Quinn1 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 2Department of Mechanical and Aerospace Engineering, University of California, San Diego The mucus plugged airways of cystic fibrosis (CF) patients are an ideal environment for microbial pathogens to thrive. The manuscript describes a novel method for studying the CF lung microbiome in an environment that mimics where they cause disease and how alterations of chemical conditions can drive microbial dynamics.