Wolfgang Wurst

Publications

• A Mouse Model for Intellectual Disability Caused by Mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 Gene
  Biochimica Et Biophysica Acta. Molecular Basis of Disease. Dec, 2018  |   Pubmed ID: 30557699
• The Trem2 R47H Alzheimer's Risk Variant Impairs Splicing and Reduces Trem2 MRNA and Protein in Mice but Not in Humans
  Molecular Neurodegeneration. 09, 2018  |   Pubmed ID: 30185230
• Exosomal Secretion of α-synuclein As Protective Mechanism After Upstream Blockage of Macroautophagy
  Cell Death & Disease. Jul, 2018  |   Pubmed ID: 29988147
• Laboratory Mouse Housing Conditions Can Be Improved Using Common Environmental Enrichment Without Compromising Data
  PLoS Biology. Apr, 2018  |   Pubmed ID: 29659570
• Identification of Genetic Elements in Metabolism by High-throughput Mouse Phenotyping
  Nature Communications. 01, 2018  |   Pubmed ID: 29348434
• Lifetime Study in Mice After Acute Low-dose Ionizing Radiation: a Multifactorial Study with Special Focus on Cataract Risk
  Radiation and Environmental Biophysics. 05, 2018  |   Pubmed ID: 29327260
• Understanding Gene Functions and Disease Mechanisms: Phenotyping Pipelines in the German Mouse Clinic
  Behavioural Brain Research. 10, 2018  |   Pubmed ID: 28966146
• Fgf9 Mutation Alters Information Processing and Social Memory in Mice
  Molecular Neurobiology. Jun, 2018  |   Pubmed ID: 28695538
• Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2017  |   Pubmed ID: 29079688
• A Large Scale Hearing Loss Screen Reveals an Extensive Unexplored Genetic Landscape for Auditory Dysfunction
  Nature Communications. 10, 2017  |   Pubmed ID: 29026089
• Every-other-day Feeding Extends Lifespan but Fails to Delay Many Symptoms of Aging in Mice
  Nature Communications. Jul, 2017  |   Pubmed ID: 28761067
• Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium
  Nature Genetics. Aug, 2017  |   Pubmed ID: 28650483
• The Pathogenic LRRK2 R1441C Mutation Induces Specific Deficits Modeling the Prodromal Phase of Parkinson's Disease in the Mouse
  Neurobiology of Disease. Sep, 2017  |   Pubmed ID: 28576705
• The FTD-like Syndrome Causing TREM2 T66M Mutation Impairs Microglia Function, Brain Perfusion, and Glucose Metabolism
  The EMBO Journal. 07, 2017  |   Pubmed ID: 28559417
• Spinal Poly-GA Inclusions in a C9orf72 Mouse Model Trigger Motor Deficits and Inflammation Without Neuron Loss
  Acta Neuropathologica. 08, 2017  |   Pubmed ID: 28409281
• Control of Gene Editing by Manipulation of DNA Repair Mechanisms
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2017  |   Pubmed ID: 28374058
• Gene Editing in Mouse Zygotes Using the CRISPR/Cas9 System
  Methods (San Diego, Calif.). 05, 2017  |   Pubmed ID: 28263886
• Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
  Neuron. Feb, 2017  |   Pubmed ID: 28111078
• Interplay Between H1 and HMGN Epigenetically Regulates OLIG1&2 Expression and Oligodendrocyte Differentiation
  Nucleic Acids Research. Apr, 2017  |   Pubmed ID: 27923998
• Genetically Dissecting P2rx7 Expression Within the Central Nervous System Using Conditional Humanized Mice
  Purinergic Signalling. 06, 2017  |   Pubmed ID: 27858314
• The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
  G3 (Bethesda, Md.). Dec, 2016  |   Pubmed ID: 27815347
• Caspase-mediated Apoptosis Induction in Zebrafish Cerebellar Purkinje Neurons
  Development (Cambridge, England). 11, 2016  |   Pubmed ID: 27729409
• Viable Ednra (Y129F) Mice Feature Human Mandibulofacial Dysostosis with Alopecia (MFDA) Syndrome Due to the Homologue Mutation
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Dec, 2016  |   Pubmed ID: 27671791
• Animal Models Are Valid to Uncover Disease Mechanisms
  PLoS Genetics. 05, 2016  |   Pubmed ID: 27227339
• CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting
  Cell Metabolism. Jun, 2016  |   Pubmed ID: 27211900
• Diversity Matters - Heterogeneity of Dopaminergic Neurons in the Ventral Mesencephalon and Its Relation to Parkinson's Disease
  Journal of Neurochemistry. 10, 2016  |   Pubmed ID: 27206718
• Diet-induced and Mono-genetic Obesity Alter Volatile Organic Compound Signature in Mice
  Journal of Breath Research. Feb, 2016  |   Pubmed ID: 26860833
• Differences in the Spatiotemporal Expression and Epistatic Gene Regulation of the Mesodiencephalic Dopaminergic Precursor Marker PITX3 During Chicken and Mouse Development
  Development (Cambridge, England). Feb, 2016  |   Pubmed ID: 26755703
• Genome Editing in Mice Using TALE Nucleases
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 26443225
• Assessing Cognition in Mice
  Current Protocols in Mouse Biology. Dec, 2015  |   Pubmed ID: 26629775
• Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors
  Frontiers in Behavioral Neuroscience. 2015  |   Pubmed ID: 26617501
• Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015  |   Pubmed ID: 26424886
• Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated Via Its C-Terminal PDZ Binding Motif
  PloS One. 2015  |   Pubmed ID: 26352593
• Beyond Knockouts: the International Knockout Mouse Consortium Delivers Modular and Evolving Tools for Investigating Mammalian Genes
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2015  |   Pubmed ID: 26340938
• Analysis of Mammalian Gene Function Through Broad-based Phenotypic Screens Across a Consortium of Mouse Clinics
  Nature Genetics. Jul, 2015  |   Pubmed ID: 26214591
• Development of an Intein-mediated Split-Cas9 System for Gene Therapy
  Nucleic Acids Research. Jul, 2015  |   Pubmed ID: 26082496
• MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation
  Developmental Cell. Jun, 2015  |   Pubmed ID: 26051541
• A WNT1-regulated Developmental Gene Cascade Prevents Dopaminergic Neurodegeneration in Adult En1(+/-) Mice
  Neurobiology of Disease. Oct, 2015  |   Pubmed ID: 26049140
• Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility
  The Journal of Biological Chemistry. Jun, 2015  |   Pubmed ID: 25922076
• Increasing the Efficiency of Homology-directed Repair for CRISPR-Cas9-induced Precise Gene Editing in Mammalian Cells
  Nature Biotechnology. May, 2015  |   Pubmed ID: 25803306
• Creation of Targeted Genomic Deletions Using TALEN or CRISPR/Cas Nuclease Pairs in One-cell Mouse Embryos
  FEBS Open Bio. 2015  |   Pubmed ID: 25685662
• Mouse IDGenes: a Reference Database for Genetic Interactions in the Developing Mouse Brain
  Database : the Journal of Biological Databases and Curation. 2014  |   Pubmed ID: 25145340
• Pleiotropic Functions for Transcription Factor Zscan10
  PloS One. 2014  |   Pubmed ID: 25111779
• Abnormal Brain Iron Metabolism in Irp2 Deficient Mice is Associated with Mild Neurological and Behavioral Impairments
  PloS One. 2014  |   Pubmed ID: 24896637
• High-throughput Phenotypic Assessment of Cardiac Physiology in Four Commonly Used Inbred Mouse Strains
  Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. Aug, 2014  |   Pubmed ID: 24788387
• A Robust and Reliable Non-invasive Test for Stress Responsivity in Mice
  Frontiers in Behavioral Neuroscience. 2014  |   Pubmed ID: 24782732
• Restless Legs Syndrome-associated Intronic Common Variant in Meis1 Alters Enhancer Function in the Developing Telencephalon
  Genome Research. Apr, 2014  |   Pubmed ID: 24642863
• Generation of Targeted Mouse Mutants by Embryo Microinjection of TALENs
  Methods (San Diego, Calif.). Aug, 2014  |   Pubmed ID: 24418396
• Wnt1-regulated Genetic Networks in Midbrain Dopaminergic Neuron Development
  Journal of Molecular Cell Biology. Feb, 2014  |   Pubmed ID: 24326514
• Efficient Isolation of Pure and Functional Mitochondria from Mouse Tissues Using Automated Tissue Disruption and Enrichment with Anti-TOM22 Magnetic Beads
  PloS One. 2013  |   Pubmed ID: 24349272
• An RNAi-based Approach to Down-regulate a Gene Family in Vivo
  PloS One. 2013  |   Pubmed ID: 24265806
• Generation of Targeted Mouse Mutants by Embryo Microinjection of TALEN MRNA
  Nature Protocols. Dec, 2013  |   Pubmed ID: 24177293
• Highly Efficient Targeted Mutagenesis in Mice Using TALENs
  Genetics. Nov, 2013  |   Pubmed ID: 23979585
• Rapamycin Extends Murine Lifespan but Has Limited Effects on Aging
  The Journal of Clinical Investigation. Aug, 2013  |   Pubmed ID: 23863708
• Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice
  PloS One. 2013  |   Pubmed ID: 23675505
• High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner
  The Journal of Biological Chemistry. Jun, 2013  |   Pubmed ID: 23620591
• Direct Production of Mouse Disease Models by Embryo Microinjection of TALENs and Oligodeoxynucleotides
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2013  |   Pubmed ID: 23426636
• In Vitro Analysis of Bone Phenotypes in Col1a1 and Jagged1 Mutant Mice Using a Standardized Osteoblast Cell Culture System
  Journal of Bone and Mineral Metabolism. May, 2013  |   Pubmed ID: 23371561
• Innovations in Phenotyping of Mouse Models in the German Mouse Clinic
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012  |   Pubmed ID: 22926221
• Voluntary Wheel Running in Mice Increases the Rate of Neurogenesis Without Affecting Anxiety-related Behaviour in Single Tests
  BMC Neuroscience. Jun, 2012  |   Pubmed ID: 22682077
• Cardiopulmonary Dysfunction in the Osteogenesis Imperfecta Mouse Model Aga2 and Human Patients Are Caused by Bone-independent Mechanisms
  Human Molecular Genetics. Aug, 2012  |   Pubmed ID: 22589248
• MAPK Signaling Determines Anxiety in the Juvenile Mouse Brain but Depression-like Behavior in Adults
  PloS One. 2012  |   Pubmed ID: 22529971
• Neurobeachin, a Regulator of Synaptic Protein Targeting, is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-mass Index in Humans
  PLoS Genetics. 2012  |   Pubmed ID: 22438821
• Pink1-deficiency in Mice Impairs Gait, Olfaction and Serotonergic Innervation of the Olfactory Bulb
  Experimental Neurology. May, 2012  |   Pubmed ID: 22265660
• Brain-specific Inactivation of the Crhr1 Gene Inhibits Post-dependent and Stress-induced Alcohol Intake, but Does Not Affect Relapse-like Drinking
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2012  |   Pubmed ID: 22113086
• Design and Generation of Gene-Targeting Vectors
  Current Protocols in Mouse Biology. Mar, 2011  |   Pubmed ID: 26068993
• Forebrain CRF₁ Modulates Early-life Stress-programmed Cognitive Deficits
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2011  |   Pubmed ID: 21940453
• Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21467037
• Forebrain CRHR1 Deficiency Attenuates Chronic Stress-induced Cognitive Deficits and Dendritic Remodeling
  Neurobiology of Disease. Jun, 2011  |   Pubmed ID: 21296667
• Constitutive and Conditional RNAi Transgenesis in Mice
  Methods (San Diego, Calif.). Apr, 2011  |   Pubmed ID: 21184828
• Mouse Phenotyping
  Methods (San Diego, Calif.). Feb, 2011  |   Pubmed ID: 20708688
• A Powerful Transgenic Tool for Fate Mapping and Functional Analysis of Newly Generated Neurons
  BMC Neuroscience. Dec, 2010  |   Pubmed ID: 21194452
• Gene Knockdown in the Mouse Through RNAi
  Methods in Enzymology. 2010  |   Pubmed ID: 20699152
• CIN85 Regulates Dopamine Receptor Endocytosis and Governs Behaviour in Mice
  The EMBO Journal. Jul, 2010  |   Pubmed ID: 20551902
• Phenotypic Annotation of the Mouse X Chromosome
  Genome Research. Aug, 2010  |   Pubmed ID: 20548051
• Central Deficiency of Corticotropin-releasing Hormone Receptor Type 1 (CRH-R1) Abolishes Effects of CRH on NREM but Not on REM Sleep in Mice
  Sleep. Apr, 2010  |   Pubmed ID: 20394311
• The Specific Role of Histone Deacetylase 2 in Adult Neurogenesis
  Neuron Glia Biology. May, 2010  |   Pubmed ID: 20388229
• Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3 ( 416insG ) Mice
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Feb, 2010  |   Pubmed ID: 20033184
• Zebrafish Reward Mutants Reveal Novel Transcripts Mediating the Behavioral Effects of Amphetamine
  Genome Biology. 2009  |   Pubmed ID: 19646228
• Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes
  PloS One. Jun, 2009  |   Pubmed ID: 19562077
• Mitochondrial Glutathione Peroxidase 4 Disruption Causes Male Infertility
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2009  |   Pubmed ID: 19417079
• Neurological Phenotype and Reduced Lifespan in Heterozygous Tim23 Knockout Mice, the First Mouse Model of Defective Mitochondrial Import
  Biochimica Et Biophysica Acta. May, 2009  |   Pubmed ID: 19111522
• Activation of ERK/MAPK in the Lateral Amygdala of the Mouse is Required for Acquisition of a Fear-potentiated Startle Response
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2009  |   Pubmed ID: 18432190
• Pleiotropic Effects in Eya3 Knockout Mice
  BMC Developmental Biology. Dec, 2008  |   Pubmed ID: 19102749
• Novel Caspase-suicide Proteins for Tamoxifen-inducible Apoptosis
  Genesis (New York, N.Y. : 2000). Oct, 2008  |   Pubmed ID: 18802959
• Novel Allele of Crybb2 in the Mouse and Its Expression in the Brain
  Investigative Ophthalmology & Visual Science. Apr, 2008  |   Pubmed ID: 18385073