Xiangzhen Yan

Department of Periodontology

School & Hospital of Stomatology, Tongji University

Xiangzhen Yan

Xiangzhen Yan is a periodontist in the Department of Periodontology, School & Hospital of Stomatology, Tongji University, Shanghai, China.

In 2002, she was enrolled in School of Stomatology, Shandong University, where she received basic education and graduated with a Bachelor degree in 2007. In the same year she was recommended to enter the graduate school in Department of Periodontology, Shandong University, where she was awarded her first Doctor degree in Clinical Science of Stomatology in 2013.

In October of 2010, she joined a cooperative project financially supported by China Scholarship Council, and started her second PhD study in Medical Science in the Department of Biomaterials at Radboudumc, the Netherlands. Her main research interests are in the area of bone and periodontal tissue regeneration utilising tissue engineering based- treatment approaches. Some of the results were presented in several international conferences among which were: International Society of Differentiation Conference 'Stem Cells, Development and Regulation' (NIRM, Amsterdam, 2012), Tissue Engineering and Regenerative Medicine International Society-Asial Pacific (TERMIS-AP, Shanghai, 2013), and the 5th international tissue engineering conference (Kos, 2014), where she received an Aegean Conference Travel Award. In September of 2014, she received her second Doctor degree in Medical Science from Radboud University, the Netherlands.

Since October 2014 she worked as a teacher and dentist in School & Hospital of Stomatology, Tongji University, continuing the clinical work as well as her research in periodontal tissue regeneration.

List of publications

(1)Yan XZ*, van den Beucken J, Yuan C, Jansen JA, Yang F*. Spheroid formation and stemness preservation of human periodontal ligament cells on chitosan films. Oral Dis. 2018 Sep;24(6):1083-1092.

(2)Yan XZ, Yang F, Jansen JA, de Vries RB, van den Beucken JJ*. Cell-based approaches in periodontal regeneration: A systematic review and meta-analysis of animal experimental work. Tissue Eng Part B Rev. 2015 Oct;21(5):411-26.

(3)Yan XZ, van den Beucken JJ, Cai X, Yu N, Jansen JA, Yang F*. Periodontal tissue regeneration using enzymatically cross-linked chitosan hydrogels with or without cell-loading. Tissue Eng Part A. 2015 Mar;21(5-6):1066-76.

(4)Yan XZ, van den Beucken JJ, Both SK, Yang PS, Jansen JA, Yang F*. Biomaterial Strategies for Stem Cell Maintenance During In Vitro Expansion. Tissue Eng Part B Rev. 2014 Aug;20(4):340-54.

(5)Yan XZ, Both SK, Yang PS, Jansen JA, van den Beucken JJ, Yang F*. Human Periodontal Ligament Derived Progenitor Cells: Effect of STRO-1 Cell Sorting and Wnt3a Treatment on Cell Behavior. Biomed Res Int. 2014;2014:145423.

(6)Yan XZ#, Nijhuis AW#, van den Beucken JJ, Both SK, Jansen JA, Leeuwenburgh SC, Yang F*. Enzymatic Control of Chitosan Gelation for Delivery of Periodontal Ligament Cells. Macromol Biosci. 2014 Jul;14(7):1004-14.

(7) Yan XZ#, Rathe F#, Gilissen C#, van der Zande M, Veltman J, Junker R, Yang F, Jansen JA*, Walboomers XF. The effect of enamel matrix derivative (Emdogain®) on gene expression profiles of human primary alveolar bone cells. J Tissue Eng Regen Med. 2014 Jun;8(6):463-72.

(8)Yan XZ#, Yang W#, Yang F, Kersten-Niessen M, Jansen JA*, Both SK. Effects of Continuous Passaging on Mineralization of MC3T3-E1 Cells with Improved Osteogenic Culture Protocol. Tissue Eng Part C Methods. 2014 Mar;20(3):198-204.

(9) Yan XZ, Ge SH, Sun QF, Guo HM, Yang PS*. A pilot study evaluating the effect of recombinant human bone morphogenetic protein-2 and recombinant human beta-nerve growth factor on the healing of Class III furcation defects in dogs. J Periodontol. 2010 Sep;81(9):1289-98.


Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

1Department of Periodontology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 2Department of Periodontology, Dental Diseases Prevention & Treatment Center of Jiading District, 3College of Materials Science and Engineering, Tongji University

JoVE 59855

 Developmental Biology