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Articles by Xiaokang Yan in JoVE
Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP Mark J. Henderson*1, Emily S. Wires*1, Kathleen A. Trychta1, Xiaokang Yan1, Brandon K. Harvey1 1National Institute on Drug Abuse, National Institutes of Health Endoplasmic reticulum calcium homeostasis is disrupted in diverse pathologies. A secreted ER calcium monitoring protein (SERCaMP) reporter can be used to detect disruptions in the ER calcium store. This protocol describes the use of a Gaussia luciferase SERCaMP to examine ER calcium homeostasis in vitro and in vivo.