In JoVE (2)
Articles by Xin Wang in JoVE
Using Microfluidics Chips for Live Imaging and Study of Injury Responses in Drosophila Larvae Bibhudatta Mishra1, Mostafa Ghannad-Rezaie2, Jiaxing Li1, Xin Wang1, Yan Hao1, Bing Ye3,4, Nikos Chronis2,5, Catherine A. Collins1 1Department of Molecular, Cellular and Developmental Biology, University of Michigan, 2Department of Biomedical Engineering, University of Michigan, 3Life Sciences Institute, University of Michigan, 4Department of Cell and Developmental Biology, University of Michigan, 5Department of Mechanical Engineering, University of Michigan Drosophila larvae are an attractive model system for live imaging due to their translucent cuticle and powerful genetics. This protocol describes how to utilize a single-layer PDMS device, called the 'larva chip' for live imaging of cellular processes within neurons of 3rd instar Drosophila larvae.
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure Zhongwei Sun1,2, Feng Li3, Xin Zhou3, Wen Wang1,2 1Cellular Biomedicine Group, Shanghai, 2Cellular Biomedicine Group, Cupertino, 3Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.
Other articles by Xin Wang on PubMed
Prediction of the Binding Model of HIV-1 Gp41 with Small Molecule Inhibitors Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2005 | Pubmed ID: 17281304 Despite the synthetic peptides inhibit HIV-1 entry; its application of this peptide therapy may be limited due to the high cost of the peptide production and lack of its oral availability. Thus, it is necessary to identify the small molecule inhibitors reacting with the same or overlapping target sites on gp41 recognizing the antiviral peptides. In this work, a small inhibitor (TP1) is docked into the hydrophobic grooves of gp41 by using AutoDock software, resulting in five alternative energetically favorable models. The data from other studies were used to define our preferred models. We found that only one binding mode is supported by the experimental evidence. The model could be used to design more effective HIV-1 inhibitors targeted to the HIV-1 gp41 core structure.
The Associations Between Health Risk Behaviors and Suicidal Ideation and Attempts in an Urban Chinese Sample of Adolescents Journal of Affective Disorders. Oct, 2010 | Pubmed ID: 20226537 To investigate the prevalence of suicidal ideation and attempts among adolescents in Guangzhou, China, and to explore the associations between health risk behaviors and suicidal behaviors.