Y. Eugene Chen Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine University of Michigan Medical Center Biography Publications Institution JoVE Articles Y. Eugene Chen has not added a biography. If you are Y. Eugene Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives International Journal of Molecular Sciences. Nov, 2018 | Pubmed ID: 30413026 Production of Immunodeficient Rabbits by Multiplex Embryo Transfer and Multiplex Gene Targeting Scientific Reports. 09, 2017 | Pubmed ID: 28939872 SysFinder: A Customized Platform for Search, Comparison and Assisted Design of Appropriate Animal Models Based on Systematic Similarity Journal of Genetics and Genomics = Yi Chuan Xue Bao. May, 2017 | Pubmed ID: 28529081 MiR-27 Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24133204 The Application of SILAC Mouse in Human Body Fluid Proteomics Analysis Reveals Protein Patterns Associated with IgA Nephropathy Evidence-based Complementary and Alternative Medicine : ECAM. 2013 | Pubmed ID: 23762118 Angiogenesis-Regulating MicroRNAs and Ischemic Stroke Current Vascular Pharmacology. May, 2013 | Pubmed ID: 23713863 Dietary Obesity-induced Egr-1 in Adipocytes Facilitates Energy Storage Via Suppression of FOXC2 Scientific Reports. 2013 | Pubmed ID: 23502673 MCPIP1 Negatively Regulates Toll-like Receptor 4 Signaling and Protects Mice from LPS-induced Septic Shock Cellular Signalling. May, 2013 | Pubmed ID: 23422584 KLF11 Mediates PPARγ Cerebrovascular Protection in Ischaemic Stroke Brain : a Journal of Neurology. Apr, 2013 | Pubmed ID: 23408111 Zc3h12c Inhibits Vascular Inflammation by Repressing NF-κB Activation and Pro-inflammatory Gene Expression in Endothelial Cells The Biochemical Journal. Apr, 2013 | Pubmed ID: 23360436 Electrophilic Nitro-fatty Acids Inhibit Vascular Inflammation by Disrupting LPS-dependent TLR4 Signalling in Lipid Rafts Cardiovascular Research. Apr, 2013 | Pubmed ID: 23334216 Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β) Protein Attenuates Vascular Lesion Formation by Inhibition of Chromatin Loading of Minichromosome Maintenance Complex in Smooth Muscle Cells The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23264620 Human Apolipoprotein A-II Protects Against Diet-induced Atherosclerosis in Transgenic Rabbits Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23241412 Paradoxical Roles of Perivascular Adipose Tissue in Atherosclerosis and Hypertension Circulation Journal : Official Journal of the Japanese Circulation Society. 2013 | Pubmed ID: 23207957 Disruption of Inducible 6-phosphofructo-2-kinase Impairs the Suppressive Effect of PPARγ Activation on Diet-induced Intestine Inflammatory Response The Journal of Nutritional Biochemistry. May, 2013 | Pubmed ID: 22841546 Diabetic HDL is Dysfunctional in Stimulating Endothelial Cell Migration and Proliferation Due to Down Regulation of SR-BI Expression PloS One. 2012 | Pubmed ID: 23133640 Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23060450 Krüppel-like Factor-11, a Transcription Factor Involved in Diabetes Mellitus, Suppresses Endothelial Cell Activation Via the Nuclear Factor-κB Signaling Pathway Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2012 | Pubmed ID: 23042817 Biochemical Characterization and Cellular Effects of CADASIL Mutants of NOTCH3 PloS One. 2012 | Pubmed ID: 23028706 Dynamic Profiles of Oct-4, Cdx-2 and Acetylated H4K5 in In-vivo-derived Rabbit Embryos Reproductive Biomedicine Online. Oct, 2012 | Pubmed ID: 22877942 Loss of Perivascular Adipose Tissue on Peroxisome Proliferator-activated Receptor-γ Deletion in Smooth Muscle Cells Impairs Intravascular Thermoregulation and Enhances Atherosclerosis Circulation. Aug, 2012 | Pubmed ID: 22855570 Recombinant Rabbit Leukemia Inhibitory Factor and Rabbit Embryonic Fibroblasts Support the Derivation and Maintenance of Rabbit Embryonic Stem Cells Cellular Reprogramming. Aug, 2012 | Pubmed ID: 22775411 Vascular Endothelial Cell-specific MicroRNA-15a Inhibits Angiogenesis in Hindlimb Ischemia The Journal of Biological Chemistry. Aug, 2012 | Pubmed ID: 22692216 Construction of Vascular Tissues with Macro-porous Nano-fibrous Scaffolds and Smooth Muscle Cells Enriched from Differentiated Embryonic Stem Cells PloS One. 2012 | Pubmed ID: 22545119 A Novel Strategy for Deciphering Dynamic Conservation of Gene Expression Relationship Journal of Molecular Cell Biology. Jun, 2012 | Pubmed ID: 22498922 Mitochondrial Dysfunction and Adipogenic Reduction by Prohibitin Silencing in 3T3-L1 Cells PloS One. 2012 | Pubmed ID: 22479600 Yap1 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22411986 Spatial and Temporal Distribution of Oct-4 and Acetylated H4K5 in Rabbit Embryos Reproductive Biomedicine Online. Apr, 2012 | Pubmed ID: 22381206 Endothelial Lipase Mediates HDL Levels in Normal and Hyperlipidemic Rabbits Journal of Atherosclerosis and Thrombosis. 2012 | Pubmed ID: 22240910 Identification and Mechanism of 10-carbon Fatty Acid As Modulating Ligand of Peroxisome Proliferator-activated Receptors The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22039047 MicroRNA and Vascular Smooth Muscle Cells Vitamins and Hormones. 2011 | Pubmed ID: 22127249 Smooth Muscle Cells for Vascular Engineering Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011 | Pubmed ID: 22096093 Follicular Oocytes Better Support Development in Rabbit Cloning Than Oviductal Oocytes Cellular Reprogramming. Dec, 2011 | Pubmed ID: 22029417 Inhibition of Gluconeogenic Genes by Calcium-regulated Heat-stable Protein 1 Via Repression of Peroxisome Proliferator-activated Receptor α The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21990353 Monocyte Chemotactic Protein-induced Protein 1 (MCPIP1) Suppresses Stress Granule Formation and Determines Apoptosis Under Stress The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 21971051 Human Apolipoprotein A-I Induces Cyclooxygenase-2 Expression and Prostaglandin I-2 Release in Endothelial Cells Through ATP-binding Cassette Transporter A1 American Journal of Physiology. Cell Physiology. Sep, 2011 | Pubmed ID: 21734188 Smooth Muscle Cell Differentiation in Vitro: Models and Underlying Molecular Mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21677291 Vascular Cell Lineage Determination and Differentiation Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21677288 Developmental Patterns of PPAR and RXR Gene Expression During Spermatogenesis Frontiers in Bioscience (Elite Edition). 2011 | Pubmed ID: 21622127 Platelet-derived Growth Factor Induces Rad Expression Through Egr-1 in Vascular Smooth Muscle Cells PloS One. 2011 | Pubmed ID: 21559360 Generation of PPARγ Mono-allelic Knockout Pigs Via Zinc-finger Nucleases and Nuclear Transfer Cloning Cell Research. Jun, 2011 | Pubmed ID: 21502977 Combined Therapeutic Strategy to Improve Vascular Endothelial Function After Implantation of Sirolimus-eluting Stents Circulation Journal : Official Journal of the Japanese Circulation Society. 2011 | Pubmed ID: 21467654 Three-dimensional Growth of IPS Cell-derived Smooth Muscle Cells on Nanofibrous Scaffolds Biomaterials. Jul, 2011 | Pubmed ID: 21439638 The Unfolded Protein Response Transducer IRE1α Prevents ER Stress-induced Hepatic Steatosis The EMBO Journal. Apr, 2011 | Pubmed ID: 21407177 Rad GTPase Inhibits Cardiac Fibrosis Through Connective Tissue Growth Factor Cardiovascular Research. Jul, 2011 | Pubmed ID: 21382976 Vascular PPARδ Protects Against Stroke-induced Brain Injury Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2011 | Pubmed ID: 21205987 Vascular Smooth Muscle Cell Peroxisome Proliferator-activated Receptor-γ Mediates Pioglitazone-reduced Vascular Lesion Formation Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2011 | Pubmed ID: 21088248 MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-like Factor 4 Stem Cells and Development. Feb, 2011 | Pubmed ID: 20799856 Porous Nanofibrous PLLA Scaffolds for Vascular Tissue Engineering Biomaterials. Nov, 2010 | Pubmed ID: 20673997 Vascular Smooth Muscle Cell Peroxisome Proliferator-activated Receptor-γ Deletion Promotes Abdominal Aortic Aneurysms Journal of Vascular Surgery. Oct, 2010 | Pubmed ID: 20630681 Nitro-oleic Acid Inhibits Angiotensin II-induced Hypertension Circulation Research. Aug, 2010 | Pubmed ID: 20558825 Involvement of Inducible 6-phosphofructo-2-kinase in the Anti-diabetic Effect of Peroxisome Proliferator-activated Receptor Gamma Activation in Mice The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20498376 Peroxisome Proliferator-activated Receptor Delta Regulation of MiR-15a in Ischemia-induced Cerebral Vascular Endothelial Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20445066 Smooth and Cardiac Muscle-selective Knock-out of Kruppel-like Factor 4 Causes Postnatal Death and Growth Retardation The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20439457 MiR-10a Contributes to Retinoid Acid-induced Smooth Muscle Cell Differentiation The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20118242 Covalent Peroxisome Proliferator-activated Receptor Gamma Adduction by Nitro-fatty Acids: Selective Ligand Activity and Anti-diabetic Signaling Actions The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20097754 MiR-497 Regulates Neuronal Death in Mouse Brain After Transient Focal Cerebral Ischemia Neurobiology of Disease. Apr, 2010 | Pubmed ID: 20053374 Disruption of Inducible 6-phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 19948719 Human C-reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits Circulation. Nov, 2009 | Pubmed ID: 19901190 Nitro-gras Acide Inhibition De La Formation Néo-intimale Après Lésion Endoluminale Circulation Research. Nov, 2009 | Pubmed ID: 19797175 The Role of Peroxisome Proliferator-activated Receptor Gamma in Blood Pressure Regulation Current Hypertension Reports. Aug, 2009 | Pubmed ID: 19602323 Vascular Smooth Muscle Cell-selective Peroxisome Proliferator-activated Receptor-gamma Deletion Leads to Hypotension Circulation. Apr, 2009 | Pubmed ID: 19364979 Ligand-activated Peroxisome Proliferator-activated Receptor-gamma Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3 Epsilon Upregulation Circulation. Mar, 2009 | Pubmed ID: 19221220 Expression Profiling of Nuclear Receptors in Human and Mouse Embryonic Stem Cells Molecular Endocrinology (Baltimore, Md.). May, 2009 | Pubmed ID: 19196830 PPARgamma and Its Ligands: Therapeutic Implications in Cardiovascular Disease Clinical Science (London, England : 1979). Feb, 2009 | Pubmed ID: 19118492 Beneficial Effect of Young Oocytes for Rabbit Somatic Cell Nuclear Transfer Cloning and Stem Cells. Mar, 2009 | Pubmed ID: 19090660 PPARs and the Cardiovascular System Antioxidants & Redox Signaling. Jun, 2009 | Pubmed ID: 19061437 A Comparison of Murine Smooth Muscle Cells Generated from Embryonic Versus Induced Pluripotent Stem Cells Stem Cells and Development. Jun, 2009 | Pubmed ID: 18795840 Gene Expression Module-based Chemical Function Similarity Search Nucleic Acids Research. Nov, 2008 | Pubmed ID: 18842630 Molecular Recognition of Nitrated Fatty Acids by PPAR Gamma Nature Structural & Molecular Biology. Aug, 2008 | Pubmed ID: 18604218 Rad GTPase Deficiency Leads to Cardiac Hypertrophy Circulation. Dec, 2007 | Pubmed ID: 18056528 A Highly Efficient Method to Differentiate Smooth Muscle Cells from Human Embryonic Stem Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2007 | Pubmed ID: 18029907 CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation Linyuan Ma*1, Lydia Jang*1, Jian Chen2, Jun Song1, Dongshan Yang1, Jifeng Zhang1, Y. Eugene Chen1, Jie Xu1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Celetrix LLC JoVE 59512 Genetics La production de lapins de Knockout apolipoprotéine C-III à l'aide de zinc nucléases doigt Dongshan Yang1, Jifeng Zhang1, Jie Xu1, Tianqing Zhu1, Yanbo Fan1, Jianglin Fan2, Y. Eugene Chen1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi JoVE 50957 Medicine
CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation Linyuan Ma*1, Lydia Jang*1, Jian Chen2, Jun Song1, Dongshan Yang1, Jifeng Zhang1, Y. Eugene Chen1, Jie Xu1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Celetrix LLC JoVE 59512 Genetics
La production de lapins de Knockout apolipoprotéine C-III à l'aide de zinc nucléases doigt Dongshan Yang1, Jifeng Zhang1, Jie Xu1, Tianqing Zhu1, Yanbo Fan1, Jianglin Fan2, Y. Eugene Chen1 1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi JoVE 50957 Medicine
