Yanan Du Department of Biomedical Engineering, School of Medicine Tsinghua University Biography Publications Institution JoVE Articles Yanan Du has not added a biography. If you are Yanan Du and would like to personalize this page please email our Author Liaison for assistance. Publications Biophysical Cues of Bone Marrow-inspired Scaffolds Regulate Hematopoiesis of Hematopoietic Stem and Progenitor Cells Biomaterials. Jul, 2023 | Pubmed ID: 37141647 Response to a Comment on "Scar-Degrading Endothelial Cells As a Treatment for Advanced Liver Fibrosis" Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Jun, 2023 | Pubmed ID: 37119442 In Situ Self-assembled Organoid for Osteochondral Tissue Regeneration with Dual Functional Units Bioactive Materials. Sep, 2023 | Pubmed ID: 37096194 Expansion of Human Megakaryocyte-biased Hematopoietic Stem Cells by Biomimetic Microniche Nature Communications. Apr, 2023 | Pubmed ID: 37072407 Advanced Glycation End-products As Mediators of the Aberrant Crosslinking of Extracellular Matrix in Scarred Liver Tissue Nature Biomedical Engineering. Apr, 2023 | Pubmed ID: 37037967 Exploring the Mechanism of Microfracture in the Treatment of Porcine Full-Thickness Cartilage Defect The American Journal of Sports Medicine. Mar, 2023 | Pubmed ID: 36802853 Intelligent Wearable Devices Based on Nanomaterials and Nanostructures for Healthcare Nanoscale. Jan, 2023 | Pubmed ID: 36519286 Scar-Degrading Endothelial Cells As a Treatment for Advanced Liver Fibrosis Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Feb, 2023 | Pubmed ID: 36494102 Injectable Bone Marrow Microniches by Co-culture of HSPCs with MSCs in 3D Microscaffolds Promote Hematopoietic Reconstitution from Acute Lethal Radiation Bioactive Materials. Apr, 2023 | Pubmed ID: 36311043 Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes Stem Cells International. 2022 | Pubmed ID: 36045953 Research Progress of Stem Cell Therapy for Endometrial Injury Materials Today. Bio. Dec, 2022 | Pubmed ID: 36033375 A Novel Step-T-Junction Microchannel for the Cell Encapsulation in Monodisperse Alginate-Gelatin Microspheres of Varying Mechanical Properties at High Throughput Biosensors. Aug, 2022 | Pubmed ID: 36005055 GMP-grade Microcarrier and Automated Closed Industrial Scale Cell Production Platform for Culture of MSCs Journal of Tissue Engineering and Regenerative Medicine. Oct, 2022 | Pubmed ID: 35929499 3D Biomaterial P Scaffolds Carrying Umbilical Cord Mesenchymal Stem Cells Improve Biointegration of Keratoprosthesis Biomedical Materials (Bristol, England). Jul, 2022 | Pubmed ID: 35790151 Engineered Meatballs Via Scalable Skeletal Muscle Cell Expansion and Modular Micro-tissue Assembly Using Porous Gelatin Micro-carriers Biomaterials. Jun, 2022 | Pubmed ID: 35679644 KRAS(G12D) Can Be Targeted by Potent Inhibitors Via Formation of Salt Bridge Cell Discovery. Jan, 2022 | Pubmed ID: 35075146 Key Considerations on the Development of Biodegradable Biomaterials for Clinical Translation of Medical Devices: With Cartilage Repair Products As an Example Bioactive Materials. Mar, 2022 | Pubmed ID: 34820574 Mechanical Communication in Fibrosis Progression Trends in Cell Biology. Jan, 2022 | Pubmed ID: 34810063 Large-Scale Expansion of Umbilical Cord Mesenchymal Stem Cells with Microcarrier Tablets in Bioreactor Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 34519979 A Low Dose Cell Therapy System for Treating Osteoarthritis: Study and Mechanistic Investigations Bioactive Materials. Jan, 2022 | Pubmed ID: 34466747 Cell Engineering Techniques Improve Pharmacology of Cellular Therapeutics Biomaterials and Biosystems. Jun, 2021 | Pubmed ID: 36824659 Synthetic Liver Fibrotic Niche Extracts Achieve Hepatoblasts Phenotype Enhancement and Expansion IScience. Nov, 2021 | Pubmed ID: 34765922 Collagen Crosslinking: Effect on Structure, Mechanics and Fibrosis Progression Biomedical Materials (Bristol, England). Oct, 2021 | Pubmed ID: 34587604 Exendin-4 Gene Modification and Microscaffold Encapsulation Promote Self-persistence and Antidiabetic Activity of MSCs Science Advances. Jul, 2021 | Pubmed ID: 34215590 Targeted Cell Therapy for Partial-thickness Cartilage Defects Using Membrane Modified Mesenchymal Stem Cells by Transglutaminase 2 Biomaterials. Aug, 2021 | Pubmed ID: 34214786 Asporin Inhibits Collagen Matrix-mediated Intercellular Mechanocommunications Between Fibroblasts During Keloid Progression FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2021 | Pubmed ID: 34105826 Efficient Endothelial and Smooth Muscle Cell Differentiation from Human Pluripotent Stem Cells Through a Simplified Insulin-free Culture System Biomaterials. Apr, 2021 | Pubmed ID: 33618219 TGase-mediated Cell Membrane Modification and Targeted Cell Delivery to Inflammatory Endothelium Biomaterials. Feb, 2021 | Pubmed ID: 32797997 Enhanced Single-cell Encapsulation in Microfluidic Devices: From Droplet Generation to Single-cell Analysis Biomicrofluidics. Nov, 2020 | Pubmed ID: 33381250 Consistent Apparent Young's Modulus of Human Embryonic Stem Cells and Derived Cell Types Stabilized by Substrate Stiffness Regulation Promotes Lineage Specificity Maintenance Cell Regeneration (London, England). Sep, 2020 | Pubmed ID: 32880028 Engineering 3D Functional Tissue Constructs Using Self-assembling Cell-laden Microniches Acta Biomaterialia. Sep, 2020 | Pubmed ID: 32771588 Matrix-transmitted Paratensile Signaling Enables Myofibroblast-fibroblast Cross Talk in Fibrosis Expansion Proceedings of the National Academy of Sciences of the United States of America. May, 2020 | Pubmed ID: 32358190 Cryoprotectant Enables Structural Control of Porous Scaffolds for Exploration of Cellular Mechano-responsiveness in 3D Nature Communications. Aug, 2019 | Pubmed ID: 31375674 High Throughput Scaffold-based 3D Micro-tumor Array for Efficient Drug Screening and Chemosensitivity Testing Biomaterials. Apr, 2019 | Pubmed ID: 29807624 Injectable Nanohydroxyapatite-chitosan-gelatin Micro-scaffolds Induce Regeneration of Knee Subchondral Bone Lesions Scientific Reports. Dec, 2017 | Pubmed ID: 29196647 A 3D-Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Aug, 2017 | Pubmed ID: 28852611 Integrating Genome-Wide Association and EQTLs Studies Identifies the Genes and Gene Sets Associated with Diabetes BioMed Research International. 2017 | Pubmed ID: 28744461 Coupling Electrochemical and Biological Methods for 17α-ethinylestradiol Removal from Water by Different Microorganisms Journal of Hazardous Materials. Oct, 2017 | Pubmed ID: 28715735 Enzymatic Competition and Cooperation Branch the Caerulomycin Biosynthetic Pathway Toward Different 2,2'-bipyridine Members Organic & Biomolecular Chemistry. Jul, 2017 | Pubmed ID: 28649680 A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis Cellular and Molecular Neurobiology. Jun, 2017 | Pubmed ID: 28639078 Dietary Safety Assessment of Genetically Modified Rice EH Rich in β-carotene Regulatory Toxicology and Pharmacology : RTP. Aug, 2017 | Pubmed ID: 28559156 Genetic Polymorphism of Epidermal Growth Factor Rs4444903 Influences Susceptibility to HCV-Related Liver Cirrhosis and Hepatocellular Carcinoma in a Chinese Han Population Clinical Laboratory. Apr, 2017 | Pubmed ID: 28397482 Genetic Polymorphism of MTHFR C677T Influences Susceptibility to HBV-Related Hepatocellular Carcinoma in a Chinese Population: a Case-Control Study Clinical Laboratory. Apr, 2017 | Pubmed ID: 28397480 GWAS Summary-based Pathway Analysis Correcting for the Genetic Confounding Impact of Environmental Exposures Briefings in Bioinformatics. Mar, 2017 | Pubmed ID: 28334273 Full-length Sequence and Genome Analysis of CHV1-CN280, a North China Isolate of Cryphonectria Hypovirus 1 Archives of Virology. Jun, 2017 | Pubmed ID: 28247097 Pathology-targeted Cell Delivery Via Injectable Micro-scaffold Capsule Mediated by Endogenous TGase Biomaterials. May, 2017 | Pubmed ID: 28237907 Biomechanically Primed Liver Microtumor Array As a High-throughput Mechanopharmacological Screening Platform for Stroma-reprogrammed Combinatorial Therapy Biomaterials. Apr, 2017 | Pubmed ID: 28182873 Optimizing Mesoderm Progenitor Selection and Three-dimensional Microniche Culture Allows Highly Efficient Endothelial Differentiation and Ischemic Tissue Repair from Human Pluripotent Stem Cells Stem Cell Research & Therapy. Jan, 2017 | Pubmed ID: 28114972 Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory Advanced Healthcare Materials. Mar, 2017 | Pubmed ID: 28105774 Preconditioning of Mesenchymal Stromal Cells Toward Nucleus Pulposus-like Cells by Microcryogels-based 3D Cell Culture and Syringe-based Pressure Loading System Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Apr, 2017 | Pubmed ID: 26584248 Influential Factors of the Indeterminate Results Tested by QuantiFERON-TB Gold In-Tube (QFT-IT) Assay for Diagnosing TB Infection in HIV-Infected Patients Clinical Laboratory. Sep, 2016 | Pubmed ID: 28164594 Keloid Progression: a Stiffness Gap Hypothesis International Wound Journal. Dec, 2016 | Pubmed ID: 27995750 3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration Scientific Reports. Aug, 2016 | Pubmed ID: 27572698 Complete Nucleotide Sequence of Magnaporthe Oryzae Partitivirus 1 Archives of Virology. Nov, 2016 | Pubmed ID: 27558124 Regeneration of Hair and Other Skin Appendages: A Microenvironment-centric View Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Sep, 2016 | Pubmed ID: 27256925 Substrate Stiffness Orchestrates Epithelial Cellular Heterogeneity with Controlled Proliferative Pattern Via E-cadherin/β-catenin Mechanotransduction Acta Biomaterialia. Sep, 2016 | Pubmed ID: 27208640 An Intensive Dispersion and Synchronous Assembly of Single-walled Carbon Nanotubes in a Surfactant-oil-water Association System Physical Chemistry Chemical Physics : PCCP. Apr, 2016 | Pubmed ID: 27041358 Engineering EMT Using 3D Micro-scaffold to Promote Hepatic Functions for Drug Hepatotoxicity Evaluation Biomaterials. Jun, 2016 | Pubmed ID: 26994875 In Vitro Cardiomyocyte-driven Biogenerator Based on Aligned Piezoelectric Nanofibers Nanoscale. Apr, 2016 | Pubmed ID: 26976074 Functional Nanoparticles Activate a Decellularized Liver Scaffold for Blood Detoxification Small (Weinheim an Der Bergstrasse, Germany). Apr, 2016 | Pubmed ID: 26914158 Multiphoton Photochemical Crosslinking-based Fabrication of Protein Micropatterns with Controllable Mechanical Properties for Single Cell Traction Force Measurements Scientific Reports. Jan, 2016 | Pubmed ID: 26817674 De Novo Assembly and Comparative Analysis of Root Transcriptomes from Different Varieties of Panax Ginseng C. A. Meyer Grown in Different Environments Science China. Life Sciences. Nov, 2015 | Pubmed ID: 26563176 Direct Intercellular Communications Dominate the Interaction Between Adipose-derived MSCs and Myofibroblasts Against Cardiac Fibrosis Protein & Cell. Oct, 2015 | Pubmed ID: 26271509 Preformed Gelatin Microcryogels As Injectable Cell Carriers for Enhanced Skin Wound Healing Acta Biomaterialia. Oct, 2015 | Pubmed ID: 26234487 Bi-content Micro-collagen Chip Provides Contractility-based Biomechanical Readout for Phenotypic Drug Screening with Expanded and Profiled Targets Lab on a Chip. Sep, 2015 | Pubmed ID: 26219255 Probing Cell-matrix Interactions in RGD-decorated Macroporous Poly (ethylene Glycol) Hydrogels for 3D Chondrocyte Culture Biomedical Materials (Bristol, England). Jun, 2015 | Pubmed ID: 26107534 Biomaterials As Carrier, Barrier and Reactor for Cell-based Regenerative Medicine Protein & Cell. Sep, 2015 | Pubmed ID: 26088192 A Ready-to-use, Versatile, Multiplex-able Three-dimensional Scaffold-based Immunoassay Chip for High Throughput Hepatotoxicity Evaluation Lab on a Chip. Jun, 2015 | Pubmed ID: 25987291 Injectable Microcryogels Reinforced Alginate Encapsulation of Mesenchymal Stromal Cells for Leak-proof Delivery and Alleviation of Canine Disc Degeneration Biomaterials. Aug, 2015 | Pubmed ID: 25956851 Discovery of the Migrasome, an Organelle Mediating Release of Cytoplasmic Contents During Cell Migration Cell Research. Jan, 2015 | Pubmed ID: 25342562 Microengineered in Vitro Model of Cardiac Fibrosis Through Modulating Myofibroblast Mechanotransduction Biofabrication. Nov, 2014 | Pubmed ID: 25378063 Downregulation of the Gli Transcription Factors Regulator Kif7 Facilitates Cell Survival and Migration of Choriocarcinoma Cells PloS One. 2014 | Pubmed ID: 25265279 Dew Inspired Breathing-based Detection of Genetic Point Mutation Visualized by Naked Eye Scientific Reports. Sep, 2014 | Pubmed ID: 25199907 Primed 3D Injectable Microniches Enabling Low-dosage Cell Therapy for Critical Limb Ischemia Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25197069 Hepatic Differentiation of Human Embryonic Stem Cells As Microscaled Multilayered Colonies Leading to Enhanced Homogeneity and Maturation Small (Weinheim an Der Bergstrasse, Germany). Nov, 2014 | Pubmed ID: 25059765 Glycerol-mediated Nanostructure Modification Leading to Improved Transparency of Porous Polymeric Scaffolds for High Performance 3D Cell Imaging Biomacromolecules. Jul, 2014 | Pubmed ID: 24884229 Magnetically Controllable 3D Microtissues Based on Magnetic Microcryogels Lab on a Chip. Aug, 2014 | Pubmed ID: 24736804 Microcryogels As Injectable 3-D Cellular Microniches for Site-directed and Augmented Cell Delivery Acta Biomaterialia. May, 2014 | Pubmed ID: 24342043 Micro-scaffold Array Chip for Upgrading Cell-based High-throughput Drug Testing to 3D Using Benchtop Equipment Lab on a Chip. Feb, 2014 | Pubmed ID: 24287736 Engineering Cell Alignment in Vitro Biotechnology Advances. Mar-Apr, 2014 | Pubmed ID: 24269848 An Aptamer Based Wall-less LSPR Array Chip for Label-free and High Throughput Detection of Biomolecules Biosensors & Bioelectronics. Mar, 2014 | Pubmed ID: 24121209 DNA-directed Self-assembly of Shape-controlled Hydrogels Nature Communications. 2013 | Pubmed ID: 24013352 A Biomimetic Physiological Model for Human Adipose Tissue by Adipocytes and Endothelial Cell Cocultures with Spatially Controlled Distribution Biomedical Materials (Bristol, England). Aug, 2013 | Pubmed ID: 23735623 Off-the-shelf Microsponge Arrays for Facile and Efficient Construction of Miniaturized 3D Cellular Microenvironments for Versatile Cell-based Assays Lab on a Chip. Jun, 2013 | Pubmed ID: 23640113 Stereotactic Radiosurgery for Trigeminal Schwannoma: a Clinical Retrospective Study in 52 Cases Stereotactic and Functional Neurosurgery. 2013 | Pubmed ID: 23548989 Delivering Instilled Hydrophobic Drug to the Bladder by a Cationic Nanoparticle and Thermo-sensitive Hydrogel Composite System Nanoscale. Oct, 2012 | Pubmed ID: 22955255 Multifaceted Applications of Nanomaterials in Cell Engineering and Therapy Biotechnology Advances. Aug, 2012 | Pubmed ID: 22922117 Perylenetetracarboxylic Diimide Derivatives Linked with Spirobifluorene Organic Letters. Jun, 2012 | Pubmed ID: 22667442 Enhanced Antitumor Efficacy of Cisplatin by Tirapazamine-transferrin Conjugate International Journal of Pharmaceutics. Jul, 2012 | Pubmed ID: 22531857 Sequential Assembly of Cell-laden Hydrogel Constructs to Engineer Vascular-like Microchannels Biotechnology and Bioengineering. Jul, 2011 | Pubmed ID: 21337336 Directed Assembly of Cell-laden Microgels for Building Porous Three-dimensional Tissue Constructs Journal of Biomedical Materials Research. Part A. Feb, 2011 | Pubmed ID: 21319297 Synthesis and Characterization of Photocrosslinkable Gelatin and Silk Fibroin Interpenetrating Polymer Network Hydrogels Acta Biomaterialia. Jun, 2011 | Pubmed ID: 21295165 A Sandwiched Microarray Platform for Benchtop Cell-based High Throughput Screening Biomaterials. Jan, 2011 | Pubmed ID: 20965560 Microfluidic Synthesis of Composite Cross-gradient Materials for Investigating Cell-biomaterial Interactions Biotechnology and Bioengineering. Jan, 2011 | Pubmed ID: 20721897 Directed Assembly of Cell-laden Hydrogels for Engineering Functional Tissues Organogenesis. Oct-Dec, 2010 | Pubmed ID: 21220962 Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels Advanced Materials (Deerfield Beach, Fla.). Dec, 2010 | Pubmed ID: 20941801 Rapid Generation of Biologically Relevant Hydrogels Containing Long-range Chemical Gradients Advanced Functional Materials. 2010 | Pubmed ID: 20216924 Convection-driven Generation of Long-range Material Gradients Biomaterials. Mar, 2010 | Pubmed ID: 20035990 Surface-directed Assembly of Cell-laden Microgels Biotechnology and Bioengineering. Feb, 2010 | Pubmed ID: 19777588 Stochastic Model of Self-assembly of Cell-laden Hydrogels Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Dec, 2009 | Pubmed ID: 20365184 Rapid Generation of Spatially and Temporally Controllable Long-range Concentration Gradients in a Microfluidic Device Lab on a Chip. Mar, 2009 | Pubmed ID: 19255657 Cell Docking in Double Grooves in a Microfluidic Channel Small (Weinheim an Der Bergstrasse, Germany). May, 2009 | Pubmed ID: 19242937 Method of Bottom-Up Directed Assembly of Cell-Laden Microgels Cellular and Molecular Bioengineering. 2008 | Pubmed ID: 19953195 Directed Assembly of Cell-laden Microgels for Fabrication of 3D Tissue Constructs Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18599452 WITHDRAWN: Microfabrication-based Engineering of the Embryonic and Adult Stem Cell Niches Biomaterials. Jun, 2008 | Pubmed ID: 18533250 Integrating Sensitive Quantification of Hepatic Metabolic Functions by Capillary Electrophoresis with Laser-induced Fluorescence Detection The Analyst. Mar, 2008 | Pubmed ID: 18299746 Synthetic Sandwich Culture of 3D Hepatocyte Monolayer Biomaterials. Jan, 2008 | Pubmed ID: 17964646 Identification and Characterization of a Novel Prespheroid 3-dimensional Hepatocyte Monolayer on Galactosylated Substratum Tissue Engineering. Jul, 2007 | Pubmed ID: 17518743 3D Hepatocyte Monolayer on Hybrid RGD/galactose Substratum Biomaterials. Nov, 2006 | Pubmed ID: 16904177 Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers (Video) | JoVE Yuyang Chen*1, Huanye Xu*2, Yuanyuan Zhang*2, Leilei Guo2, Miaomiao Lan2, Yanping Yang2, Wei Liu2, Xiaojun Yan2, Yanan Du1 1Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Beijing CytoNiche Biotechnology Co. Ltd. JoVE 65469 Bioengineering 3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening Yaqian Li*1,2, Xiaojun Yan*1, Wei Liu*1, Lyu Zhou1,3, Zhifeng You1, Yanan Du1,2 1Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 3School of Life Sciences, Tsinghua University JoVE 55982 Bioengineering
Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers (Video) | JoVE Yuyang Chen*1, Huanye Xu*2, Yuanyuan Zhang*2, Leilei Guo2, Miaomiao Lan2, Yanping Yang2, Wei Liu2, Xiaojun Yan2, Yanan Du1 1Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Beijing CytoNiche Biotechnology Co. Ltd. JoVE 65469 Bioengineering
3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening Yaqian Li*1,2, Xiaojun Yan*1, Wei Liu*1, Lyu Zhou1,3, Zhifeng You1, Yanan Du1,2 1Department of Biomedical Engineering, School of Medicine, Tsinghua University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 3School of Life Sciences, Tsinghua University JoVE 55982 Bioengineering
