Articles by Yong Gu in JoVE
מבחני Electrochemiluminescence עבור האדם איון עצמיים Yong Gu1,2, Zhiyuan Zhao1, Dongmei Miao1, Hilary High1, Tao Yang2, Liping Yu1 1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 2Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University כאן, הצגנו את השיטות כדי לזהות עצמיים איון האנושי באמצעות מבחני electrochemiluminescence (ECL). הפרוטוקול, השתמשו כדי לחזות סוכרת מסוג 1, ניתן להרחיב על כדי לזהות עצמיים למחלות אוטואימוניות אחרות.
Other articles by Yong Gu on PubMed
The Heterogeneity of Islet Autoantibodies and the Progression of Islet Failure in Type 1 Diabetic Patients Science China. Life Sciences. Sep, 2016 | Pubmed ID: 27225179 Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobinA1c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1DM patients (duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus.