Yonghong Wan Biography Publications JoVE Articles Yonghong Wan has not added a biography. If you are Yonghong Wan and would like to personalize this page please email our Author Liaison for assistance. Publications A Transit Time-Resolved Microflow Cytometry-Based Agglutination Immunoassay for On-Site C-Reactive Protein Detection Micromachines. Jan, 2021 | Pubmed ID: 33499089 De Novo Necroptosis Creates an Inflammatory Environment Mediating Tumor Susceptibility to Immune Checkpoint Inhibitors Communications Biology. Nov, 2020 | Pubmed ID: 33149194 Enhanced Immunotherapeutic Profile of Oncolytic Virus-based Cancer Vaccination Using Cyclophosphamide Preconditioning Journal for Immunotherapy of Cancer. 08, 2020 | Pubmed ID: 32792361 A Rational Relationship: Oncolytic Virus Vaccines As Functional Partners for Adoptive T Cell Therapy Cytokine & Growth Factor Reviews. Dec, 2020 | Pubmed ID: 32665126 Ketogenesis-generated β-hydroxybutyrate is an Epigenetic Regulator of CD8 T-cell Memory Development Nature Cell Biology. 01, 2020 | Pubmed ID: 31871320 Endogenous T Cells Prevent Tumor Immune Escape Following Adoptive T Cell Therapy The Journal of Clinical Investigation. 12, 2019 | Pubmed ID: 31682239 Preclinical Evaluation of a MAGE-A3 Vaccination Utilizing the Oncolytic Maraba Virus Currently in First-in-human Trials Oncoimmunology. 2019 | Pubmed ID: 30546947 Type I IFN Blockade Uncouples Immunotherapy-induced Antitumor Immunity and Autoimmune Toxicity The Journal of Clinical Investigation. 02, 2019 | Pubmed ID: 30422820 Development and Applications of Oncolytic Maraba Virus Vaccines Oncolytic Virotherapy. 2018 | Pubmed ID: 30538968 HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants Cell Reports. 07, 2018 | Pubmed ID: 30021162 Transforming the Prostatic Tumor Microenvironment with Oncolytic Virotherapy Oncoimmunology. 2018 | Pubmed ID: 29900060 Preclinical Development of Peptide Vaccination Combined with Oncolytic MG1-E6E7 for HPV-associated Cancer Vaccine. 04, 2018 | Pubmed ID: 29544689 A Pck1-directed Glycogen Metabolic Program Regulates Formation and Maintenance of Memory CD8 T Cells Nature Cell Biology. 01, 2018 | Pubmed ID: 29230018 Customized Viral Immunotherapy for HPV-Associated Cancer Cancer Immunology Research. Oct, 2017 | Pubmed ID: 28912369 Capitalizing on Cancer Specific Replication: Oncolytic Viruses As a Versatile Platform for the Enhancement of Cancer Immunotherapy Strategies Biomedicines. Aug, 2016 | Pubmed ID: 28536388 Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination Journal of Immunology (Baltimore, Md. : 1950). Jun, 2016 | Pubmed ID: 27183620 Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses Via an IL-1-Dependent Pathway PLoS Pathogens. 05, 2016 | Pubmed ID: 27148737 High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells PloS One. 2016 | Pubmed ID: 27064901 S6K-STING Interaction Regulates Cytosolic DNA-mediated Activation of the Transcription Factor IRF3 Nature Immunology. May, 2016 | Pubmed ID: 27043414 Mechanistic Insights into the Oncolytic Activity of Vesicular Stomatitis Virus in Cancer Immunotherapy Oncolytic Virotherapy. 2015 | Pubmed ID: 27512679 T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2015 | Pubmed ID: 26122933 Type I IFN Signaling on Dendritic Cells is Required for NK Cell-mediated Anti-tumor Immunity Innate Immunity. Aug, 2015 | Pubmed ID: 25749844 Cell-free Tumor Microparticle Vaccines Stimulate Dendritic Cells Via CGAS/STING Signaling Cancer Immunology Research. Feb, 2015 | Pubmed ID: 25477253 Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War Against Cancer Frontiers in Oncology. 2014 | Pubmed ID: 24967214 Maraba Virus As a Potent Oncolytic Vaccine Vector Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2014 | Pubmed ID: 24322333 Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2014 | Pubmed ID: 24196579 Oncolytic Vesicular Stomatitis Virus Quantitatively and Qualitatively Improves Primary CD8 T-cell Responses to Anticancer Vaccines Oncoimmunology. Aug, 2013 | Pubmed ID: 24083086 Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation Journal of Immunology (Baltimore, Md. : 1950). May, 2013 | Pubmed ID: 23554310 Delivery of Viral-vectored Vaccines by B Cells Represents a Novel Strategy to Accelerate CD8(+) T-cell Recall Responses Blood. Mar, 2013 | Pubmed ID: 23325836 HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23295947 Combined Vaccination and Immunostimulatory Antibodies Provides Durable Cure of Murine Melanoma and Induces Transcriptional Changes Associated with Positive Outcome in Human Melanoma Patients Oncoimmunology. Jul, 2012 | Pubmed ID: 22754760 ORFV:新規腫瘍溶解性と免疫刺激パラポックスウイルス治療 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012 | Pubmed ID: 22273579 組み合わせたmTOR阻害剤とOX40アゴニズムはCD8(+)T細胞のメモリーおよび組換えアデノウイルスワクチンプロデュース防御免疫を強化 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 22186790 癌免疫療法を強化するためのエンジニアリング·樹状細胞 Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2011 | Pubmed ID: 21468005 IL-15とI型インターフェロンは、ウイルスに感染した樹状細胞による抗腫瘍NK細胞の活性化に必要で Cancer Research. Apr, 2011 | Pubmed ID: 21307131 寛容原性樹状細胞およびその潜在的なアプリケーション Immunology. Mar, 2011 | Pubmed ID: 21208205 適応抗ウイルス免疫が腫瘍溶解性ウイルス療法の治療の成功の決定要因である Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011 | Pubmed ID: 21119618 組換えアデノウイルス接種後のCD8 + T細胞の拡張およびメンテナンスは造血系および非造血系抗原提示細胞間の協力に頼る Blood. Jan, 2011 | Pubmed ID: 21088134 腫瘍溶解性ウイルスを用いた癌免疫を増強する Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010 | Pubmed ID: 20551919 免疫療法は、標的抗原を共有するにもかかわらず、脳に損傷を与えることなく頭蓋内腫瘍細胞を拒絶することはでき Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010 | Pubmed ID: 20237288 腫瘍抗原の処理は差のあるヘルパーとエフェクターCD4 + T細胞応答の発達に影響を与える Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2010 | Pubmed ID: 20179673 オートファジーは、B16メラノーマ細胞におけるIFN-γにより誘導された主要組織適合遺伝子複合体クラスI発現を促進 Cancer Immunology, Immunotherapy : CII. Feb, 2010 | Pubmed ID: 19680649 導入遺伝子発現の持続性は、組換えアデノウイルスによる免疫後CD8 + T細胞の拡張とメンテナンスに影響を与える Journal of Virology. Dec, 2009 | Pubmed ID: 19759135 アデノウイルスブースト迅速に従順首相抗腫瘍免疫に新たな癌ワクチンのベクターとしては水疱性口内炎ウイルス Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2009 | Pubmed ID: 19603003 樹状細胞の組換え水疱性口内炎ウイルス形質導入は、内閣総理自然免疫と適応抗腫瘍免疫能力を強化 Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2009 | Pubmed ID: 19401673 ネオアジュバントワクチンは、アジュバントワクチンと比べて術後の腫瘍再発に対する優れた保護を提供します。 Cancer Research. May, 2009 | Pubmed ID: 19383917 CD4 + T細胞介在性抗腫瘍免疫がSTAT4/STAT6シグナリング軸経由で自己免疫から切り離されることができます European Journal of Immunology. May, 2009 | Pubmed ID: 19338001 Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2008 | Pubmed ID: 28178541 粘膜納入樹状細胞は独立してIL-12と内因性APCのT細胞を活性化 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2008 | Pubmed ID: 18684925 抗原と樹状細胞のin Vitroロード中のための斬新なアプローチとして、内部リボソームエントリーサイト主導のmRNAの翻訳により、強化されたタンパク質発現 Human Immunology. Jan, 2008 | Pubmed ID: 18295673 樹状細胞ワクチンによって誘発される強化された抗腫瘍免疫両方のCTLとIFNガンマ生産NK細胞に従事する能力の結果である Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2008 | Pubmed ID: 18059374 組換えウイルスベクタープロデュースCD8 + T細胞応答の大きさは、抗原とベクトルの両方の関数である Cellular Immunology. Nov-Dec, 2007 | Pubmed ID: 18313652 ペプチドパルス樹状細胞から放出されるエキソソームによる抗原提示は、Active CTLの存在によって抑制されていない Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17911587 異種抗原で免疫後の上昇自己反応性CD8の周波数+ T細胞は異語幹変化CD4 + T細胞ヘルパーエピトープの存在によるものである Cancer Research. Jul, 2007 | Pubmed ID: 17616707 CD8 + T細胞応答におけるCD4 + T細胞の役割に組換えアデノウイルスワクチンによって誘発される Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2007 | Pubmed ID: 17375073 タバコの煙は、NK細胞依存性腫瘍免疫監視機構を損なう Journal of Immunology (Baltimore, Md. : 1950). Jan, 2007 | Pubmed ID: 17202355 CD8 + T細胞集団組換えアデノウイルスによって誘発されるには、それにもかかわらず長期的な耐性を提供します。長時間抗原提示に関連付けられた新しい部分果て表現型を表示します。 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16365411 セルベースの結核ワクチンの開発:遺伝子組み換え樹状細胞ワクチンは、ペプチドまたはタンパク質にロードされたものよりCD4とCD8 T細胞のはるかに強力な活性化因子である Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2006 | Pubmed ID: 16343993 組換えアデノウイルスワクチンは成功しましたエクストリーム白血球の条件の下でCD8 + T細胞免疫を引き出すこと Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2006 | Pubmed ID: 16297666 アデノウイルスとポックスウイルス·ベクタ結核ワクチンの開発における最近の進歩 Current Gene Therapy. Oct, 2005 | Pubmed ID: 16250889 T-細胞媒介性炎症は、マウスの気道機能不全の維持に寄与しない Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2004 | Pubmed ID: 15286049 CTL-依存性および非依存性抗腫瘍免疫、腫瘍はワクチンによって決定されます Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15100257 白斑免疫ワクチン誘発性皮膚へのセカンダリ外傷の結果である Cancer Research. Feb, 2004 | Pubmed ID: 14973051 TNF-αは、細胞内細菌感染時にはタイプ1免疫活性化の重要な負の調節因子である The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14755337 ハイリスク限局性前立腺癌におけるインターロイキン2のアデノベクター媒介送達の第I相試験(アディル-2) Cancer Gene Therapy. Oct, 2003 | Pubmed ID: 14502228 Benzenedicarboxylatesと1,10 - フェナントロリンによる希土類イオンの自己組織化から高次元のアーキテクチャ Inorganic Chemistry. Aug, 2003 | Pubmed ID: 12895124 CD4の浸潤およびダイレクト蓄積でマウスとラットの結果肺にリンホタクチンのアデノウイルス媒介遺伝子導入+、CD8 +、およびNK細胞 Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. May, 2002 | Pubmed ID: 12060496 Dendritic Cell-derived IL-12 is Not Required for the Generation of Cytotoxic, IFN-gamma-secreting, CD8(+) CTL in Vivo Journal of Immunology (Baltimore, Md. : 1950). Nov, 2001 | Pubmed ID: 11673511 Role of Dendritic Cell-derived Cytokines in Immune Regulation Current Pharmaceutical Design. Jul, 2001 | Pubmed ID: 11472250 Effects of Stuffer DNA on Transgene Expression from Helper-dependent Adenovirus Vectors Journal of Virology. Oct, 1999 | Pubmed ID: 10482551 Functional Analysis of Tumor-Infiltrating Myeloid Cells by Flow Cytometry and Adoptive Transfer JoVE 61511 Cancer Research 骨髄前駆細胞から骨髄樹状細胞の培養 Jeanette Boudreau1,2, Sandeep Koshy2,3, Derek Cummings2, Yonghong Wan2 1Medical Sciences Program, McMaster University, 2Centre for Gene Therapeutics, McMaster University, 3Department of Chemical Engineering, University of Waterloo JoVE 769 Biology
Functional Analysis of Tumor-Infiltrating Myeloid Cells by Flow Cytometry and Adoptive Transfer JoVE 61511 Cancer Research
骨髄前駆細胞から骨髄樹状細胞の培養 Jeanette Boudreau1,2, Sandeep Koshy2,3, Derek Cummings2, Yonghong Wan2 1Medical Sciences Program, McMaster University, 2Centre for Gene Therapeutics, McMaster University, 3Department of Chemical Engineering, University of Waterloo JoVE 769 Biology