Yu-Hua Tseng

Publications

• Adipose Tissue in Communication: Within and Without
  Nature Reviews. Endocrinology. Feb, 2023  |   Pubmed ID: 36526875
• Aberrant Expression of Agouti Signaling Protein (ASIP) As a Cause of Monogenic Severe Childhood Obesity
  Nature Metabolism. Dec, 2022  |   Pubmed ID: 36536132
• ADRA1A-Gα Signalling Potentiates Adipocyte Thermogenesis Through CKB and TNAP
  Nature Metabolism. Nov, 2022  |   Pubmed ID: 36344764
• Architecture of the Outbred Brown Fat Proteome Defines Regulators of Metabolic Physiology
  Cell. Nov, 2022  |   Pubmed ID: 36334589
• Phosphatase Protector Alpha4 (α4) is Involved in Adipocyte Maintenance and Mitochondrial Homeostasis Through Regulation of Insulin Signaling
  Nature Communications. Oct, 2022  |   Pubmed ID: 36241662
• Brown Adipose Tissue-derived MaR2 Contributes to Cold-induced Resolution of Inflammation
  Nature Metabolism. Jun, 2022  |   Pubmed ID: 35760872
• Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure
  Frontiers in Bioengineering and Biotechnology. 2022  |   Pubmed ID: 35646839
• Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis
  Circulation Research. Jul, 2022  |   Pubmed ID: 35642564
• Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice
  International Journal of Molecular Sciences. May, 2022  |   Pubmed ID: 35628137
• Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells
  Stem Cells (Dayton, Ohio). 03, 2022  |   Pubmed ID: 35511869
• Ejection of Damaged Mitochondria and Their Removal by Macrophages Ensure Efficient Thermogenesis in Brown Adipose Tissue
  Cell Metabolism. Apr, 2022  |   Pubmed ID: 35305295
• Signaling Lipidomic Analysis of Thermogenic Adipocytes
  Methods in Molecular Biology (Clifton, N.J.). 2022  |   Pubmed ID: 35167102
• Characterization of Transcript Enrichment and Detection Bias in Single-nucleus RNA-seq for Mapping of Distinct Human Adipocyte Lineages
  Genome Research. Feb, 2022  |   Pubmed ID: 35042723
• The Evolving View of Thermogenic Adipocytes - Ontogeny, Niche and Function
  Nature Reviews. Endocrinology. Dec, 2021  |   Pubmed ID: 34625737
• N-butylidenephthalide Ameliorates High-fat Diet-induced Obesity in Mice and Promotes Browning Through Adrenergic Response/AMPK Activation in Mouse Beige Adipocytes
  Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Dec, 2021  |   Pubmed ID: 34487913
• β3-Adrenergic Receptors Regulate Human Brown/beige Adipocyte Lipolysis and Thermogenesis
  JCI Insight. Jun, 2021  |   Pubmed ID: 34100382
• Narrating the Story ARC of Adipose Tissue Aging
  Developmental Cell. May, 2021  |   Pubmed ID: 34004148
• Cold-induction of Afadin in Brown Fat Supports Its Thermogenic Capacity
  Scientific Reports. May, 2021  |   Pubmed ID: 33963248
• Challenges in Tackling Energy Expenditure As Obesity Therapy: From Preclinical Models to Clinical Application
  Molecular Metabolism. Sep, 2021  |   Pubmed ID: 33878401
• Defining the Lineage of Thermogenic Perivascular Adipose Tissue
  Nature Metabolism. Apr, 2021  |   Pubmed ID: 33846639
• Vascular Smooth Muscle-derived Trpv1 Progenitors Are a Source of Cold-induced Thermogenic Adipocytes
  Nature Metabolism. Apr, 2021  |   Pubmed ID: 33846638
• Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
  Cell Reports. Jan, 2021  |   Pubmed ID: 33440156
• Adipocyte Microenvironment: Everybody in the Neighborhood Talks About the Temperature
  Cell Metabolism. Jan, 2021  |   Pubmed ID: 33406404
• Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity
  The Journal of Clinical Endocrinology and Metabolism. Jan, 2021  |   Pubmed ID: 33135728
• The Involvement of Neuroimmune Cells in Adipose Innervation
  Molecular Medicine (Cambridge, Mass.). 12, 2020  |   Pubmed ID: 33297933
• CRISPR-engineered Human Brown-like Adipocytes Prevent Diet-induced Obesity and Ameliorate Metabolic Syndrome in Mice
  Science Translational Medicine. Aug, 2020  |   Pubmed ID: 32848096
• Lipidomics of Brown and White Adipose Tissue: Implications for Energy Metabolism
  Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Oct, 2020  |   Pubmed ID: 32763428
• The Link Between Stress and IL-6 Is Heating Up
  Cell Metabolism. Aug, 2020  |   Pubmed ID: 32755607
• The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue
  Diabetes. Aug, 2020  |   Pubmed ID: 32690661
• Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells
  Cell. Aug, 2020  |   Pubmed ID: 32679029
• Integrated Metabolomics Reveals Altered Lipid Metabolism in Adipose Tissue in a Model of Extreme Longevity
  GeroScience. Dec, 2020  |   Pubmed ID: 32632845
• Commentary On: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans"
  The Journal of Clinical Endocrinology and Metabolism. Aug, 2020  |   Pubmed ID: 32559764
• The Perlman Syndrome DIS3L2 Exoribonuclease Safeguards Endoplasmic Reticulum-targeted MRNA Translation and Calcium Ion Homeostasis
  Nature Communications. May, 2020  |   Pubmed ID: 32457326
• Single-cell Transcriptional Networks in Differentiating Preadipocytes Suggest Drivers Associated with Tissue Heterogeneity
  Nature Communications. Apr, 2020  |   Pubmed ID: 32355218
• Parental Metabolic Syndrome Epigenetically Reprograms Offspring Hepatic Lipid Metabolism in Mice
  The Journal of Clinical Investigation. May, 2020  |   Pubmed ID: 32250344
• Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer
  Methods in Molecular Biology (Clifton, N.J.). 2020  |   Pubmed ID: 32219757
• FGF6 and FGF9 Regulate UCP1 Expression Independent of Brown Adipogenesis
  Nature Communications. Mar, 2020  |   Pubmed ID: 32184391
• Cell-autonomous Light Sensitivity Via Opsin3 Regulates Fuel Utilization in Brown Adipocytes
  PLoS Biology. Feb, 2020  |   Pubmed ID: 32040503
• Lipokines and Thermogenesis
  Endocrinology. Oct, 2019  |   Pubmed ID: 31504387
• 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
  Cell Metabolism. Oct, 2019  |   Pubmed ID: 31353262
• Afadin is a Scaffold Protein Repressing Insulin Action Via HDAC6 in Adipose Tissue
  EMBO Reports. Aug, 2019  |   Pubmed ID: 31264358
• ComBATing Aging-does Increased Brown Adipose Tissue Activity Confer Longevity?
  GeroScience. Jun, 2019  |   Pubmed ID: 31230192
• TGF-β2 is an Exercise-induced Adipokine That Regulates Glucose and Fatty Acid Metabolism
  Nature Metabolism. Feb, 2019  |   Pubmed ID: 31032475
• Insulin Receptor-mediated Signaling Regulates Pluripotency Markers and Lineage Differentiation
  Molecular Metabolism. 12, 2018  |   Pubmed ID: 30316806
• Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism
  Cell Reports. Jul, 2018  |   Pubmed ID: 30021173
• RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells
  Angewandte Chemie (International Ed. in English). Aug, 2018  |   Pubmed ID: 29952110
• Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
  Cell Metabolism. Jul, 2018  |   Pubmed ID: 29861389
• 12,13-diHOME: An Exercise-Induced Lipokine That Increases Skeletal Muscle Fatty Acid Uptake
  Cell Metabolism. May, 2018  |   Pubmed ID: 29719226
• Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species
  Lipids. Jan, 2018  |   Pubmed ID: 29488636
• Brown Adipose Tissue Thermogenic Adaptation Requires Nrf1-mediated Proteasomal Activity
  Nature Medicine. Mar, 2018  |   Pubmed ID: 29400713
• Deciphering Adipose Tissue Heterogeneity
  Annals of the New York Academy of Sciences. Jan, 2018  |   Pubmed ID: 28763833
• Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences Between Brown and White Adipocytes
  Cell Reports. Dec, 2017  |   Pubmed ID: 29241534
• Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A
  Endocrinology. 12, 2017  |   Pubmed ID: 29040444
• MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure
  Frontiers in Endocrinology. 2017  |   Pubmed ID: 28878735
• NFIA Co-localizes with PPARγ and Transcriptionally Controls the Brown Fat Gene Program
  Nature Cell Biology. Sep, 2017  |   Pubmed ID: 28812581
• Ca-associated Triphasic PH Changes in Mitochondria During Brown Adipocyte Activation
  Molecular Metabolism. Aug, 2017  |   Pubmed ID: 28752044
• Identification and Characterization of a Supraclavicular Brown Adipose Tissue in Mice
  JCI Insight. Jun, 2017  |   Pubmed ID: 28570265
• Optical Visualisation of Thermogenesis in Stimulated Single-cell Brown Adipocytes
  Scientific Reports. May, 2017  |   Pubmed ID: 28469146
• The Cold-induced Lipokine 12,13-diHOME Promotes Fatty Acid Transport into Brown Adipose Tissue
  Nature Medicine. May, 2017  |   Pubmed ID: 28346411
• Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 28244042
• Shades of Brown: an Introduction for the Special Focus Issue of Adipocyte on "brown and Beige/brite Adipocytes"
  Adipocyte. Apr, 2016  |   Pubmed ID: 30168365
• Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals
  Cell Metabolism. 09, 2016  |   Pubmed ID: 27626200
• Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry
  Metabolites. Aug, 2016  |   Pubmed ID: 27548241
• Loss of BMP Receptor Type 1A in Murine Adipose Tissue Attenuates Age-related Onset of Insulin Resistance
  Diabetologia. Aug, 2016  |   Pubmed ID: 27209464
• Tribbles 3 Inhibits Brown Adipocyte Differentiation and Function by Suppressing Insulin Signaling
  Biochemical and Biophysical Research Communications. Feb, 2016  |   Pubmed ID: 26801556
• 3D Brown Adipogenesis to Create "Brown-Fat-in-Microstrands"
  Biomaterials. Jan, 2016  |   Pubmed ID: 26496384
• The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation
  Genes & Diseases. Jun, 2015  |   Pubmed ID: 26491708
• MicroRNA-455 Regulates Brown Adipogenesis Via a Novel HIF1an-AMPK-PGC1α Signaling Network
  EMBO Reports. Oct, 2015  |   Pubmed ID: 26303948
• Curcumin Analogues As Selective Fluorescence Imaging Probes for Brown Adipose Tissue and Monitoring Browning
  Scientific Reports. Aug, 2015  |   Pubmed ID: 26269357
• Clonal Analyses and Gene Profiling Identify Genetic Biomarkers of the Thermogenic Potential of Human Brown and White Preadipocytes
  Nature Medicine. Jul, 2015  |   Pubmed ID: 26076036
• Genetic and Functional Characterization of Clonally Derived Adult Human Brown Adipocytes
  Nature Medicine. Apr, 2015  |   Pubmed ID: 25774848
• Disruption of Insulin Signaling in Myf5-expressing Progenitors Leads to Marked Paucity of Brown Fat but Normal Muscle Development
  Endocrinology. May, 2015  |   Pubmed ID: 25625589
• A Novel Role for Subcutaneous Adipose Tissue in Exercise-induced Improvements in Glucose Homeostasis
  Diabetes. Jun, 2015  |   Pubmed ID: 25605808
• Unwiring the Transcriptional Heat Circuit
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014  |   Pubmed ID: 25261553
• ASC-1, PAT2, and P2RX5 Are Cell Surface Markers for White, Beige, and Brown Adipocytes
  Science Translational Medicine. Jul, 2014  |   Pubmed ID: 25080478
• IRF4 is a Key Thermogenic Transcriptional Partner of PGC-1α
  Cell. Jul, 2014  |   Pubmed ID: 24995979
• Isolation of Progenitors That Exhibit Myogenic/osteogenic Bipotency in Vitro by Fluorescence-activated Cell Sorting from Human Fetal Muscle
  Stem Cell Reports. Jan, 2014  |   Pubmed ID: 24678452
• Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells Via a BMP4-NFATc1-thrombospondin-1 Axis
  Cell. Jan, 2014  |   Pubmed ID: 24485453
• Glial Cell Line-derived Neurotrophic Factor Protects Against High-fat Diet-induced Obesity
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2014  |   Pubmed ID: 24458024
• Brown Fat Fuel Utilization and Thermogenesis
  Trends in Endocrinology and Metabolism: TEM. Apr, 2014  |   Pubmed ID: 24389130
• Systemic Control of Brown Fat Thermogenesis: Integration of Peripheral and Central Signals
  Annals of the New York Academy of Sciences. Oct, 2013  |   Pubmed ID: 24111913
• Quantification of Human and Rodent Brown Adipose Tissue Function Using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2013  |   Pubmed ID: 24071505
• Brown Adipose Tissue: Development, Metabolism and Beyond
  The Biochemical Journal. Jul, 2013  |   Pubmed ID: 23805974
• Anatomical Localization, Gene Expression Profiling and Functional Characterization of Adult Human Neck Brown Fat
  Nature Medicine. May, 2013  |   Pubmed ID: 23603815
• Anti-melanin-concentrating Hormone Treatment Attenuates Chronic Experimental Colitis and Fibrosis
  American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2013  |   Pubmed ID: 23538494
• Brown-fat Paucity Due to Impaired BMP Signalling Induces Compensatory Browning of White Fat
  Nature. Mar, 2013  |   Pubmed ID: 23485971
• Ablation of TRIP-Br2, a Regulator of Fat Lipolysis, Thermogenesis and Oxidative Metabolism, Prevents Diet-induced Obesity and Insulin Resistance
  Nature Medicine. Feb, 2013  |   Pubmed ID: 23291629
• P62 Links β-adrenergic Input to Mitochondrial Function and Thermogenesis
  The Journal of Clinical Investigation. Jan, 2013  |   Pubmed ID: 23257354
• Brown Adipose Tissue Regulates Glucose Homeostasis and Insulin Sensitivity
  The Journal of Clinical Investigation. Jan, 2013  |   Pubmed ID: 23221344
• Increased Mitochondrial Activity in BMP7-treated Brown Adipocytes, Due to Increased CPT1- and CD36-mediated Fatty Acid Uptake
  Antioxidants & Redox Signaling. Jul, 2013  |   Pubmed ID: 22938691
• Brown Adipose Tissue: Recent Insights into Development, Metabolic Function and Therapeutic Potential
  Adipocyte. Jan, 2012  |   Pubmed ID: 23700507
• Intrinsic Differences in Adipocyte Precursor Cells from Different White Fat Depots
  Diabetes. Jul, 2012  |   Pubmed ID: 22596050
• Bone Morphogenetic Protein 7 (BMP7) Reverses Obesity and Regulates Appetite Through a Central MTOR Pathway
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2012  |   Pubmed ID: 22331196
• Necdin Controls Proliferation of White Adipocyte Progenitor Cells
  PloS One. 2012  |   Pubmed ID: 22292082
• Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-associated Pathways
  Endocrinology. Oct, 2011  |   Pubmed ID: 21862615
• Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity
  PloS One. Feb, 2011  |   Pubmed ID: 21311592
• Identification of Inducible Brown Adipocyte Progenitors Residing in Skeletal Muscle and White Fat
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21173238
• Cross Talk Between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
  Molecular and Cellular Biology. Sep, 2010  |   Pubmed ID: 20584981
• Cellular Bioenergetics As a Target for Obesity Therapy
  Nature Reviews. Drug Discovery. Jun, 2010  |   Pubmed ID: 20514071
• Insulin and Insulin-like Growth Factor-1 Receptors Act As Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription
  The Journal of Biological Chemistry. May, 2010  |   Pubmed ID: 20360006
• Emerging Role of Bone Morphogenetic Proteins in Adipogenesis and Energy Metabolism
  Cytokine & Growth Factor Reviews. 2009  |   Pubmed ID: 19896888
• Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated with Human Obesity
  Diabetes. Sep, 2009  |   Pubmed ID: 19502417
• Identification and Importance of Brown Adipose Tissue in Adult Humans
  The New England Journal of Medicine. Apr, 2009  |   Pubmed ID: 19357406
• New Role of Bone Morphogenetic Protein 7 in Brown Adipogenesis and Energy Expenditure
  Nature. Aug, 2008  |   Pubmed ID: 18719589
• Substance P As a Novel Anti-obesity Target
  Gastroenterology. Mar, 2008  |   Pubmed ID: 18325388
• Dissection of the Insulin Signaling Pathway Via Quantitative Phosphoproteomics
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18268350
• Rad GTPase Deficiency Leads to Cardiac Hypertrophy
  Circulation. Dec, 2007  |   Pubmed ID: 18056528
• Developmental Origin of Fat: Tracking Obesity to Its Source
  Cell. Oct, 2007  |   Pubmed ID: 17956727
• Loss of ARNT/HIF1beta Mediates Altered Gene Expression and Pancreatic-islet Dysfunction in Human Type 2 Diabetes
  Cell. Aug, 2005  |   Pubmed ID: 16096055
• Prediction of Preadipocyte Differentiation by Gene Expression Reveals Role of Insulin Receptor Substrates and Necdin
  Nature Cell Biology. Jun, 2005  |   Pubmed ID: 15895078
• Central Role of Suppressors of Cytokine Signaling Proteins in Hepatic Steatosis, Insulin Resistance, and the Metabolic Syndrome in the Mouse
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004  |   Pubmed ID: 15240880
• Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
  Molecular and Cellular Biology. Mar, 2004  |   Pubmed ID: 14966273
• Differential Roles of Insulin Receptor Substrates in the Anti-apoptotic Function of Insulin-like Growth Factor-1 and Insulin
  The Journal of Biological Chemistry. Aug, 2002  |   Pubmed ID: 12082100
• Molecular Balance Between the Regulatory and Catalytic Subunits of Phosphoinositide 3-kinase Regulates Cell Signaling and Survival
  Molecular and Cellular Biology. Feb, 2002  |   Pubmed ID: 11784871
• Interaction of the Ras-related Protein Associated with Diabetes Rad and the Putative Tumor Metastasis Suppressor NM23 Provides a Novel Mechanism of GTPase Regulation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 1999  |   Pubmed ID: 10611312