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门静脉注射结直肠癌类器官研究肝转移基质

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

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癌症研究

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JoVE 杂志癌症研究

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

门静脉注射结直肠癌类器官研究肝转移基质

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6,346 Views

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07:59 min

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September 03, 2021

DOI:

10.3791/62630-v

DOI:

10.3791/62630-v

•

07:59 min

September 03, 2021

•

6280 Views

Hiroki Kobayashi^1,2,3,4, Krystyna A. Gieniec^1,2, Jia Q. Ng^1,2, Jarrad Goyne^1,2, Tamsin R. M. Lannagan^1,2, Elaine M. Thomas^1,2, Georgette Radford^1,2, Tongtong Wang^1,2, Nobumi Suzuki^1,2,5, Mari Ichinose^1,2, Josephine A. Wright², Laura Vrbanac^1,2, Alastair D. Burt⁶, Masahide Takahashi^3,4,7, Atsushi Enomoto³, Daniel L. Worthley², Susan L. Woods^1,2

¹Adelaide Medical School,University of Adelaide ²South Australian Health and Medical Research Institute (SAHMRI)³Department of Pathology,Nagoya University Graduate School of Medicine ⁴Division of Molecular Pathology, Center for Neurological Disease and Cancer,Nagoya University Graduate School of Medicine ⁵Department of Gastroenterology, Graduate School of Medicine,The University of Tokyo ⁶Translational and Clinical Research Institute,Newcastle University ⁷International Center for Cell and Gene Therapy,Fujita Health University

Summary

门静脉注射结直肠癌（CRC）类器官可产生富含基质的肝转移。这种CRC肝转移的小鼠模型代表了研究肿瘤 - 基质相互作用和开发新型基质导向疗法（如腺相关病毒介导的基因疗法）的有用工具。

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