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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model
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医学
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JoVE 杂志 医学
Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

DOI:
10.3791/63839-v

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08:51 min

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November 11, 2022

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, , , , ,
1Department of Surgery,Yale University School of Medicine, 2Department of Vascular Surgery,The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine,Yale University School of Medicine, 5Department of Cell Biology,Yale University School of Medicine

Summary

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This protocol provides a step-by-step procedure for executing multiple intravenous bolus dose administration and invasive hemodynamic monitoring in mice. Investigators can use this protocol for future therapeutic compound screening for pulmonary artery hypertension.

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Intravenous Bolus DosingInvasive Hemodynamic AssessmentHypoxia-induced Pulmonary Artery HypertensionMouse ModelJugular Vein InjectionArterial CatheterizationRight Ventricular CatheterizationBlood Pressure MeasurementDrug DevelopmentCompound Screening

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