Zigang Li Pingshan Translational Medicine Center Shenzhen Bay Laboratory Biography Publications Institution JoVE Articles Zigang Li has not added a biography. If you are Zigang Li and would like to personalize this page please email our Author Liaison for assistance. Publications A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization Organic Letters. Sep, 2022 | Pubmed ID: 36169233 Biodistribution, Degradability and Clearance of 2D Materials for Their Biomedical Applications Chemical Society Reviews. Sep, 2022 | Pubmed ID: 36047060 Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction Journal of Medicinal Chemistry. Sep, 2022 | Pubmed ID: 36044768 Histidine-specific Bioconjugation Visible-light-promoted Thioacetal Activation Chemical Science. Jul, 2022 | Pubmed ID: 35919717 Sulfonium-Tethered Peptide Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 35761049 Therapeutic Potential for Amyloid Surface Inhibitor: Only Amyloid-β Oligomers Formed by Secondary Nucleation Disrupt Lipid Membrane Integrity The FEBS Journal. Jun, 2022 | Pubmed ID: 35670622 Diversity-Oriented Synthesis of ERα Modulators Via Mitsunobu Macrocyclization Organic Letters. 05, 2022 | Pubmed ID: 35546524 Flavin Catalyzed Desulfurization of Peptides and Proteins in Aqueous Media Organic & Biomolecular Chemistry. 05, 2022 | Pubmed ID: 35546316 Whole-body PET Tracking of a D-dodecapeptide and Its Radiotheranostic Potential for PD-L1 Overexpressing Tumors Acta Pharmaceutica Sinica. B. Mar, 2022 | Pubmed ID: 35530129 A Novel Inhibitor of -methyladenosine Demethylase FTO Induces MRNA Methylation and Shows Anti-cancer Activities Acta Pharmaceutica Sinica. B. Feb, 2022 | Pubmed ID: 35256950 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells Analytical Chemistry. 03, 2022 | Pubmed ID: 35244395 Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking ACS Chemical Biology. 03, 2022 | Pubmed ID: 35225603 Sulfonium Triggered Alkyne-Azide Click Cycloaddition Organic Letters. 02, 2022 | Pubmed ID: 35156827 Identification of an Autoinhibitory, Mitophagy-inducing Peptide Derived from the Transmembrane Domain of USP30 Autophagy. 09, 2022 | Pubmed ID: 34989313 Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease Journal of Medicinal Chemistry. 01, 2022 | Pubmed ID: 34981929 Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media Organic Letters. 01, 2022 | Pubmed ID: 34968069 Tetrahedral DNA Nanostructure Based Biosensor for High-performance Detection of Circulating Tumor DNA Using All-carbon Nanotube Transistor Biosensors & Bioelectronics. Feb, 2022 | Pubmed ID: 34800925 Helical Stabilization of Peptide Macrocycles by Stapled Architectures Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 34596860 Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary Frontiers in Chemistry. 2021 | Pubmed ID: 34676198 Potent Inhibition of HIF1α and P300 Interaction by a Constrained Peptide Derived from CITED2 Journal of Medicinal Chemistry. 09, 2021 | Pubmed ID: 34472840 Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34386967 SOD1 is a Possible Predictor of COVID-19 Progression As Revealed by Plasma Proteomics ACS Omega. Jul, 2021 | Pubmed ID: 34250342 Molecular Design of Stapled Pentapeptides As Building Blocks of Self-assembled Coiled Coil-like Fibers Science Advances. 01, 2021 | Pubmed ID: 33523941 Structural Insights into the Inhibition of Bacterial RecA by Naphthalene Polysulfonated Compounds IScience. Jan, 2021 | Pubmed ID: 33458611 Universal DNA Detection Realized by Peptide Based Carbon Nanotube Biosensors Nanoscale Advances. Feb, 2020 | Pubmed ID: 36133222 An Overview of the Safety, Clinical Application and Antiviral Research of the COVID-19 Therapeutics Journal of Infection and Public Health. Oct, 2020 | Pubmed ID: 32684351 Dual-acidity-labile Polysaccharide-di-drugs Conjugate for Targeted Cancer Chemotherapy European Journal of Medicinal Chemistry. Aug, 2020 | Pubmed ID: 32474350 Renin-angiotensin System Inhibitors Improve the Clinical Outcomes of COVID-19 Patients with Hypertension Emerging Microbes & Infections. Dec, 2020 | Pubmed ID: 32228222 Intramolecular Methionine Alkylation Constructs Sulfonium Tethered Peptides for Protein Conjugation Chemical Communications (Cambridge, England). Apr, 2020 | Pubmed ID: 32124910 Targeting the Amyloid-β Fibril Surface with a Constrained Helical Peptide Inhibitor Biochemistry. 01, 2020 | Pubmed ID: 31702899 Computational Elucidation of the Binding Mechanisms of Curcumin Analogues As Bacterial RecA Inhibitors RSC Advances. Jun, 2019 | Pubmed ID: 35519399 Directional Assembly of a Stapled α-helical Peptide Chemical Communications (Cambridge, England). Aug, 2019 | Pubmed ID: 31414101 Uncariitannin, a Polyphenolic Polymer from Uncaria Gambier, Attenuates Staphylococcus Aureus Virulence Through an MgrA-mediated Regulation of α-hemolysin Pharmacological Research. 09, 2019 | Pubmed ID: 31288080 α-Helical Motif As Inhibitors of Toxic Amyloid-β Oligomer Generation Via Highly Specific Recognition of Amyloid Surface IScience. Jul, 2019 | Pubmed ID: 31255986 A Sulfonium Tethered Peptide Ligand Rapidly and Selectively Modifies Protein Cysteine in Vicinity Chemical Science. May, 2019 | Pubmed ID: 31183045 Design and Synthetic Strategies for Helical Peptides Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31134570 Autophagy Inducing Cyclic Peptides Constructed by Methionine Alkylation Chemical Communications (Cambridge, England). Apr, 2019 | Pubmed ID: 30896003 Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells Cancer Research. 04, 2019 | Pubmed ID: 30842103 Organosilicon Modification to Enhance the Stability of Black Phosphorus Nanosheets Under Ambient Conditions Journal of Materials Chemistry. B. Jun, 2018 | Pubmed ID: 32255150 Recent Advances in Peptidomimetics Antagonists Targeting Estrogen Receptor α-coactivator Interaction in Cancer Therapy Bioorganic & Medicinal Chemistry Letters. May, 2018 | Pubmed ID: 30025900 Evaluation of Topologically Distinct Constrained Antimicrobial Peptides with Broad-spectrum Antimicrobial Activity Organic & Biomolecular Chemistry. Jul, 2018 | Pubmed ID: 30004546 Reversible Stapling of Unprotected Peptides Chemoselective Methionine Bis-alkylation/dealkylation Chemical Science. Mar, 2018 | Pubmed ID: 29844896 Tuning Peptide Self-assembly by an In-tether Chiral Center Science Advances. May, 2018 | Pubmed ID: 29756036 Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Frontiers in Microbiology. 2018 | Pubmed ID: 29731745 N Terminal N-methylation Modulates Chiral Centre Induced Helical (CIH) Peptides' Biophysical Properties Chemical Communications (Cambridge, England). Feb, 2018 | Pubmed ID: 29388647 A Virus-like Particle of the Hepatitis B Virus PreS Antigen Elicits Robust Neutralizing Antibodies and T Cell Responses in Mice Antiviral Research. 01, 2018 | Pubmed ID: 29129705 Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides Through Amphiphilicity Tuning Chemical Science. Nov, 2017 | Pubmed ID: 29568420 High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors Against Staphylococcus Aureus Current Medicinal Chemistry. Nov, 2017 | Pubmed ID: 29165063 Development of a High Quantum Yield Dye for Tumour Imaging Chemical Science. Sep, 2017 | Pubmed ID: 28989666 An In-tether Chiral Center Modulates the Proapoptotic Activity of the KLA Peptide Chemical Communications (Cambridge, England). Sep, 2017 | Pubmed ID: 28884757 Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study Chembiochem : a European Journal of Chemical Biology. 11, 2017 | Pubmed ID: 28876512 Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides Bioconjugate Chemistry. 07, 2017 | Pubmed ID: 28650634 A Precisely Positioned Chiral Center in an I, I + 7 Tether Modulates the Helicity of the Backbone Peptide Chemical Communications (Cambridge, England). Jun, 2017 | Pubmed ID: 28585955 Dual In-Tether Chiral Centers Modulate Peptide Helicity Bioconjugate Chemistry. 05, 2017 | Pubmed ID: 28445034 SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer Theranostics. 2017 | Pubmed ID: 28435453 Switching Substitution Groups on the In-tether Chiral Centre Influences Backbone Peptides' Permeability and Target Binding Affinity Organic & Biomolecular Chemistry. Jan, 2017 | Pubmed ID: 27929189 Improving Cell Penetration of Helical Peptides Stabilized by N-terminal Crosslinked Aspartic Acids Organic & Biomolecular Chemistry. Jan, 2017 | Pubmed ID: 27924991 An In-tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-capped Peptides Bioorganic & Medicinal Chemistry. 03, 2017 | Pubmed ID: 27919612 Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity Scientific Reports. 12, 2016 | Pubmed ID: 27934919 An In-tether Sulfilimine Chiral Center Induces β-turn Conformation in Short Peptides Organic & Biomolecular Chemistry. Oct, 2016 | Pubmed ID: 27722542 Crosslinked Aspartic Acids As Helix-Nucleating Templates Angewandte Chemie (International Ed. in English). 09, 2016 | Pubmed ID: 27572954 Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus Aureus Cell Chemical Biology. Aug, 2016 | Pubmed ID: 27499528 An In-tether Sulfilimine Chiral Center Induces Helicity in Short Peptides Chemical Communications (Cambridge, England). Aug, 2016 | Pubmed ID: 27480995 Constructing Thioether-tethered Cyclic Peptides Via On-resin Intra-molecular Thiol-ene Reaction Journal of Peptide Science : an Official Publication of the European Peptide Society. Aug, 2016 | Pubmed ID: 27378284 A Proline-derived Transannular N-cap for Nucleation of Short α-helical Peptides Chemical Communications (Cambridge, England). Jul, 2016 | Pubmed ID: 27357119 A Thioether-Stabilized D-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida Albicans Ability Chembiochem : a European Journal of Chemical Biology. 08, 2016 | Pubmed ID: 27194395 An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide Angewandte Chemie (International Ed. in English). 07, 2016 | Pubmed ID: 27167181 E2 Regulates MMP-13 Via Targeting MiR-140 in IL-1β-induced Extracellular Matrix Degradation in Human Chondrocytes Arthritis Research & Therapy. May, 2016 | Pubmed ID: 27165343 Solution-processed Photodetectors Based on Organic-inorganic Hybrid Perovskite and Nanocrystalline Graphite Nanotechnology. Apr, 2016 | Pubmed ID: 26978061 Iron Homeostasis Regulates the Activity of the MicroRNA Pathway Through Poly(C)-binding Protein 2 Cell Metabolism. Jun, 2012 | Pubmed ID: 22633452 A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification The Journal of Organic Chemistry. | Pubmed ID: 31899633 Constructing Cyclic Peptides Using an On-Tether Sulfonium Center Chunli Song*1, Zhanfeng Hou*1,2, Zijun Jiao*1, Zhaodi Liu3, Chenshan Lian1,2, Min Zhang1, Wei Liang3, Feng Yin1,2, Zigang Li1,2 1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University JoVE 64289 Chemie Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation Xiaodong Shi*1, Yinghuan Liu*1, Rongtong Zhao1, Zigang Li1 1Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School JoVE 57356 Chemie
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center Chunli Song*1, Zhanfeng Hou*1,2, Zijun Jiao*1, Zhaodi Liu3, Chenshan Lian1,2, Min Zhang1, Wei Liang3, Feng Yin1,2, Zigang Li1,2 1Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital, Anhui Medical University JoVE 64289 Chemie
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation Xiaodong Shi*1, Yinghuan Liu*1, Rongtong Zhao1, Zigang Li1 1Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School JoVE 57356 Chemie
