Login-Verarbeitung ...

Trial ends in Request Full Access Tell Your Colleague About Jove

6.8: Single-Strand DNA Binding Proteins

JoVE Core
Molecular Biology

Ein Abonnement für JoVE ist erforderlich, um diesen Inhalt ansehen zu können. Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.

Single-Strand DNA Binding Proteins

6.8: Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes it rigid. This is believed to enhance DNA polymerase ability to correctly select bases, thereby increasing the fidelity of DNA replication.

The ever-growing threat of drug-resistant microorganisms demands the development of antibiotics with new targets. Due to their involvement in DNA replication, recombination, and repair, SSB proteins are being investigated for this purpose.

Suggested Reading


Keywords: Single-strand DNA Binding Proteins DNA Replication Single-stranded DNA DNA Polymerase DNA Fidelity Drug-resistant Microorganisms Antibiotics DNA Recombination DNA Repair

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter