generation-and-manipulation-of-rat-intestinal-organoids

Generation and Manipulation of Rat Intestinal Organoids

When using organoids to assess physiology and cell fate decisions, it is important to use a model that closely recapitulates in vivo contexts. ...

Yale School of Medicine

Organoid development and organ-on-a-chip are technologies based on differentiating stem cells, forming 3D multicellular structures resembling organs and tissues in vivo. Hence, both can be strategically used for disease modeling, drug screening, and host-pathogen studies. In this context, this review highlights the significant advancements in the area, providing technical approaches to organoids and organ-on-a-chip that best imitate in vivo physiology.

Strategic use of organoids and organs-on-chip as biomimetic tools.

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl/HCO  channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many gastrointestinal diseases. Defects in CFTR lead to intestinal dysfunction, malabsorption, obstruction, infection, inflammation, and cancer that increases morbidity and reduces quality of life. This review will focus on CFTR in the intestine and the implications of the subpopulation of CFTR High Expresser Cells (CHEs) in Cystic Fibrosis (CF), intestinal physiology and pathophysiology of intestinal diseases.

Article	Year
Strategic use of organoids and organs-on-chip as biomimetic tools. Seminars in cell & developmental biology\| PubMed ID: 36192310	2023
CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon\| PubMed ID: 36967909	2023

Anderson K. Santos

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