Annet Kirabo Division of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center and Department of Molecular Physiology and Biophysics Vanderbilt University Biography Publications Institution JoVE Articles Annet Kirabo has not added a biography. If you are Annet Kirabo and would like to personalize this page please email our Author Liaison for assistance. Publications Salt and Gut Microbiota in Heart Failure Current Hypertension Reports. May, 2023 | Pubmed ID: 37219766 Mechanisms of Oxidative Stress in Metabolic Syndrome International Journal of Molecular Sciences. Apr, 2023 | Pubmed ID: 37175603 The Epithelial Sodium Channel in Inflammation and Blood Pressure Modulation Frontiers in Cardiovascular Medicine. 2023 | Pubmed ID: 37123470 Intestinal Lymphatic Dysfunction in Kidney Disease Circulation Research. Apr, 2023 | Pubmed ID: 37104557 Gut Microbiota Dependant Trimethylamine N-oxide and Hypertension Frontiers in Physiology. 2023 | Pubmed ID: 37089429 βARs: Double Edge Sword in Heart Function Trends in Molecular Medicine. Jun, 2023 | Pubmed ID: 36990857 Novel Concepts in Nephron Sodium Transport: A Physiological and Clinical Perspective Advances in Kidney Disease and Health. Mar, 2023 | Pubmed ID: 36868728 Meet the Novel Players in Hypertensive Kidney Disease: Septin4 and SIRT2 Circulation Research. Mar, 2023 | Pubmed ID: 36862813 Post-COVID-19 Afferent Baroreflex Failure Hypertension (Dallas, Tex. : 1979). May, 2023 | Pubmed ID: 36802914 Salt Taste and Salt Sensitive Hypertension in HIV Current Hypertension Reports. Mar, 2023 | Pubmed ID: 36800166 In Memoriam: Fernando Elijovich Hypertension (Dallas, Tex. : 1979). Jan, 2023 | Pubmed ID: 36475860 Inflammation and Oxidative Stress in Salt Sensitive Hypertension; The Role of the NLRP3 Inflammasome Frontiers in Physiology. 2022 | Pubmed ID: 36620210 Sex Differences in Hypertension Among People Living with HIV After Initiation of Antiretroviral Therapy Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36465432 Dendritic Cell Epithelial Sodium Channel in Inflammation, Salt-Sensitive Hypertension, and Kidney Damage Kidney360. Sep, 2022 | Pubmed ID: 36245645 Rare Variants in Genes Encoding Subunits of the Epithelial Na Channel Are Associated With Blood Pressure and Kidney Function Hypertension (Dallas, Tex. : 1979). Nov, 2022 | Pubmed ID: 36193739 Dicarbonyl-modified Lipoproteins Contribute to Proteinuric Kidney Injury JCI Insight. Nov, 2022 | Pubmed ID: 36125905 Immediate Pressor Response to Oral Salt and Its Assessment in the Clinic: a Time Series Clinical Trial Clinical Hypertension. Sep, 2022 | Pubmed ID: 36104796 Hypertension and Human Immunodeficiency Virus: A Paradigm for Epithelial Sodium Channels? Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36093171 DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension Circulation Research. Aug, 2022 | Pubmed ID: 35862128 Kidney Tubular IL-1β ENaCtivation in Diabetes and Salt-Sensitive Hypertension Circulation Research. Jun, 2022 | Pubmed ID: 35737755 The Gut Microbiota and Short-Chain Fatty Acids Profile in Postural Orthostatic Tachycardia Syndrome Frontiers in Physiology. 2022 | Pubmed ID: 35733987 Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease Current Hypertension Reports. Oct, 2022 | Pubmed ID: 35727522 Enhanced Parasympathetic Cholinergic Activity with Galantamine Inhibited Lipid-induced Oxidative Stress in Obese African Americans Molecular Medicine (Cambridge, Mass.). Jun, 2022 | Pubmed ID: 35659521 Isolevuglandins Disrupt PU.1-mediated C1q Expression and Promote Autoimmunity and Hypertension in Systemic Lupus Erythematosus JCI Insight. Jul, 2022 | Pubmed ID: 35608913 Recent Advances in Modulation of Cardiovascular Diseases by the Gut Microbiota Journal of Human Hypertension. Nov, 2022 | Pubmed ID: 35469059 Hypersensitive or Hypertensive? IgE-FcɛR1 Signalling in Mast Cells Adds a New Piece to the Immunity and Hypertension Puzzle Cardiovascular Research. Nov, 2022 | Pubmed ID: 35417016 Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging Biomolecules. Mar, 2022 | Pubmed ID: 35327604 Bile Acids and Salt-sensitive Hypertension: a Role of the Gut-liver Axis American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2022 | Pubmed ID: 35245132 Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics International Journal of Molecular Sciences. Jan, 2022 | Pubmed ID: 35163352 Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease Current Hypertension Reports. May, 2022 | Pubmed ID: 35124768 Salt-Sensitivity of Blood Pressure and Insulin Resistance Frontiers in Physiology. 2021 | Pubmed ID: 34966295 Salt Sensitivity of Volume and Blood Pressure in a Mouse with Globally Reduced ENaC γ-subunit Expression American Journal of Physiology. Renal Physiology. Dec, 2021 | Pubmed ID: 34632813 Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na Channel Antioxidants & Redox Signaling. Dec, 2021 | Pubmed ID: 34569287 Immune Mechanisms of Dietary Salt-Induced Hypertension and Kidney Disease: Harry Goldblatt Award for Early Career Investigators 2020 Hypertension (Dallas, Tex. : 1979). Aug, 2021 | Pubmed ID: 34232678 Kidney Injury-mediated Disruption of Intestinal Lymphatics Involves Dicarbonyl-modified Lipoproteins Kidney International. Jun, 2021 | Pubmed ID: 34102217 Hypertension: Do Inflammation and Immunity Hold the Key to Solving This Epidemic? Circulation Research. Apr, 2021 | Pubmed ID: 33793336 Epithelial Sodium Channel and Salt-Sensitive Hypertension Hypertension (Dallas, Tex. : 1979). Mar, 2021 | Pubmed ID: 33486988 Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T-Cell Activation in the Heart and Promote Cardiac Dysfunction Circulation. Mar, 2021 | Pubmed ID: 33463362 HIV-positive Demonstrate More Salt Sensitivity and Nocturnal Non-dipping Blood Pressure Than HIV-negative Individuals Clinical Hypertension. Jan, 2021 | Pubmed ID: 33446278 The Role of Inflammation in Hypertension: Novel Concepts Current Opinion in Physiology. Feb, 2021 | Pubmed ID: 33073072 Sodium Activates Human Monocytes Via the NADPH Oxidase and Isolevuglandin Formation Cardiovascular Research. Apr, 2021 | Pubmed ID: 33038226 Scavenging Reactive Lipids to Prevent Oxidative Injury Annual Review of Pharmacology and Toxicology. 01, 2021 | Pubmed ID: 32997599 Hypothesis: Unrecognized Actions of ENaC Blockade in Improving Refractory-resistant Hypertension and Residual Cardiovascular Risk International Journal of Cardiology. Hypertension. Dec, 2020 | Pubmed ID: 33447773 Hypertension and Metabolic Syndrome in Persons with HIV Current Hypertension Reports. 09, 2020 | Pubmed ID: 32880756 The Gut Microbiome, Inflammation, and Salt-Sensitive Hypertension Current Hypertension Reports. 09, 2020 | Pubmed ID: 32880753 ENaC in Salt-Sensitive Hypertension: Kidney and Beyond Current Hypertension Reports. 08, 2020 | Pubmed ID: 32852643 Blood Pressure, T Cells, and Mortality in People with HIV in Tanzania During the First 2 years of Antiretroviral Therapy Journal of Clinical Hypertension (Greenwich, Conn.). 09, 2020 | Pubmed ID: 32815636 New Insights Into the Renin-Angiotensin System in Chronic Kidney Disease Circulation Research. Aug, 2020 | Pubmed ID: 32790525 Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension JACC. Basic to Translational Science. Jun, 2020 | Pubmed ID: 32613146 From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension Hypertension (Dallas, Tex. : 1979). 04, 2020 | Pubmed ID: 32078385 Elevated Eosinophils As a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV Journal of the American Heart Association. 02, 2020 | Pubmed ID: 32064996 Isolevuglandins As Mediators of Disease and the Development of Dicarbonyl Scavengers As Pharmaceutical Interventions Pharmacology & Therapeutics. Jan, 2020 | Pubmed ID: 31629006 Dendritic Cell A20: Targeting Hypertension in Autoimmunity Circulation Research. 12, 2019 | Pubmed ID: 31804913 HIV, Immune Activation and Salt-sensitive Hypertension (HISH): a Research Proposal BMC Research Notes. Jul, 2019 | Pubmed ID: 31311574 High Salt Activates CD11c Antigen-Presenting Cells Via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension Hypertension (Dallas, Tex. : 1979). 09, 2019 | Pubmed ID: 31280647 Patho-immune Mechanisms of Hypertension in HIV: a Systematic and Thematic Review Current Hypertension Reports. 06, 2019 | Pubmed ID: 31165257 High Dietary Salt-induced Dendritic Cell Activation Underlies Microbial Dysbiosis-associated Hypertension JCI Insight. 06, 2019 | Pubmed ID: 31162138 Mechanisms of Isolevuglandin-protein Adduct Formation in Inflammation and Hypertension Prostaglandins & Other Lipid Mediators. Nov, 2018 | Pubmed ID: 30278231 High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity Diabetes. 11, 2018 | Pubmed ID: 30181158 Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension Cell Reports. Oct, 2017 | Pubmed ID: 29069584 A New Paradigm of Sodium Regulation in Inflammation and Hypertension American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2017 | Pubmed ID: 28931546 A New Role of Mister (MR) T in Hypertension: Mineralocorticoid Receptor, Immune System, and Hypertension Circulation Research. May, 2017 | Pubmed ID: 28495982 Neuregulin-1β Induces Proliferation, Survival and Paracrine Signaling in Normal Human Cardiac Ventricular Fibroblasts Journal of Molecular and Cellular Cardiology. 04, 2017 | Pubmed ID: 28263756 Dendritic Cells and Isolevuglandins in Immunity, Inflammation, and Hypertension American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2017 | Pubmed ID: 27986660 Do High-salt Microenvironments Drive Hypertensive Inflammation? American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 01, 2017 | Pubmed ID: 27903514 CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli Circulation Research. Apr, 2016 | Pubmed ID: 26988069 Immune Activation Caused by Vascular Oxidation Promotes Fibrosis and Hypertension The Journal of Clinical Investigation. Jan, 2016 | Pubmed ID: 26595812 Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension Circulation Research. Aug, 2015 | Pubmed ID: 26156232 Inflammation, Immunity, and Hypertensive End-organ Damage Circulation Research. Mar, 2015 | Pubmed ID: 25767287 Lymphocyte Adaptor Protein LNK Deficiency Exacerbates Hypertension and End-organ Inflammation The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25664851 Renal Transporter Activation During Angiotensin-II Hypertension is Blunted in Interferon-γ-/- and Interleukin-17A-/- Mice Hypertension (Dallas, Tex. : 1979). Mar, 2015 | Pubmed ID: 25601932 Oligoclonal CD8+ T Cells Play a Critical Role in the Development of Hypertension Hypertension (Dallas, Tex. : 1979). Nov, 2014 | Pubmed ID: 25259750 DC Isoketal-modified Proteins Activate T Cells and Promote Hypertension The Journal of Clinical Investigation. Oct, 2014 | Pubmed ID: 25244096 Inflammation and Mechanical Stretch Promote Aortic Stiffening in Hypertension Through Activation of P38 Mitogen-activated Protein Kinase Circulation Research. Feb, 2014 | Pubmed ID: 24347665 Murine Fecal Isolation and Microbiota Transplantation Jeanne A. Ishimwe1, Jianyong Zhong2,3, Valentina Kon2, Annet Kirabo1 1Division of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center and Department of Molecular Physiology and Biophysics, Vanderbilt University, 2Division of Pediatric Nephrology Department of Pediatrics, Vanderbilt University Medical Center, 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center JoVE 64310 Inmunología e infección Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence Cassandra Warden*1, Alan J. Simmons*2, Lejla Pasic3, Ashley Pitzer4,6, Sean S. Davies4, Justin H. Layer5, Raymond L. Mernaugh3, Annet Kirabo4,6 1Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2Department of Cell and Developmental Biology, Vanderbilt University, 3Department of Biochemistry, Vanderbilt University, 4Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 5Division of Hematology and Oncology, Indiana University School of Medicine, 6Department of Molecular Physiology and Biophysics, Vanderbilt University JoVE 62603 Biología Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells Justin P. Van Beusecum1, Liang Xiao1, Natalia R. Barbaro1, David M. Patrick1, Annet Kirabo1 1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center JoVE 59124 Inmunología e infección
Murine Fecal Isolation and Microbiota Transplantation Jeanne A. Ishimwe1, Jianyong Zhong2,3, Valentina Kon2, Annet Kirabo1 1Division of Clinical Pharmacology, Department of Medicine Vanderbilt University Medical Center and Department of Molecular Physiology and Biophysics, Vanderbilt University, 2Division of Pediatric Nephrology Department of Pediatrics, Vanderbilt University Medical Center, 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center JoVE 64310 Inmunología e infección
Direct Detection of Isolevuglandins in Tissues Using a D11 scFv-Alkaline Phosphatase Fusion Protein and Immunofluorescence Cassandra Warden*1, Alan J. Simmons*2, Lejla Pasic3, Ashley Pitzer4,6, Sean S. Davies4, Justin H. Layer5, Raymond L. Mernaugh3, Annet Kirabo4,6 1Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2Department of Cell and Developmental Biology, Vanderbilt University, 3Department of Biochemistry, Vanderbilt University, 4Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 5Division of Hematology and Oncology, Indiana University School of Medicine, 6Department of Molecular Physiology and Biophysics, Vanderbilt University JoVE 62603 Biología
Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells Justin P. Van Beusecum1, Liang Xiao1, Natalia R. Barbaro1, David M. Patrick1, Annet Kirabo1 1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center JoVE 59124 Inmunología e infección
