Karla J. Hutt Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology Monash University Biography Publications Institution JoVE Articles Karla J. Hutt has not added a biography. If you are Karla J. Hutt and would like to personalize this page please email our Author Liaison for assistance. Publications Radiotherapy Exposure Directly Damages the Uterus and Causes Pregnancy Loss JCI Insight. Mar, 2023 | Pubmed ID: 36946464 Beyond Apoptosis: Evidence of Other Regulated Cell Death Pathways in the Ovary Throughout Development and Life Human Reproduction Update. Feb, 2023 | Pubmed ID: 36857094 Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice Cells. Feb, 2023 | Pubmed ID: 36831314 Does Single-strand DNA Break Repair Capacity Influence Oocyte Maintenance and Quality? Reproduction (Cambridge, England). Dec, 2022 | Pubmed ID: 36215096 Melatonin As an Oncostatic Agent: Review of the Modulation of Tumor Microenvironment and Overcoming Multidrug Resistance Biochimie. Nov, 2022 | Pubmed ID: 36116742 Checkpoint Inhibitor Immunotherapy Diminishes Oocyte Number and Quality in Mice Nature Cancer. Aug, 2022 | Pubmed ID: 36008687 Development of an Embryo Transfer Model to Study Uterine Contributions to Pregnancy in Mice Reproduction & Fertility. Jan, 2022 | Pubmed ID: 35198982 Prolonged Atrazine Exposure Beginning and Adult Uterine Morphology in Mice Journal of Developmental Origins of Health and Disease. Feb, 2022 | Pubmed ID: 33781367 HENMT1 is Involved in the Maintenance of Normal Female Fertility in the Mouse Molecular Human Reproduction. Nov, 2021 | Pubmed ID: 34590701 Assessment of Ovarian Function in Phase III (Neo)Adjuvant Breast Cancer Clinical Trials: A Systematic Evaluation Journal of the National Cancer Institute. Nov, 2021 | Pubmed ID: 34048575 Evaluation of Mitochondria in Mouse Oocytes Following Cisplatin Exposure Journal of Ovarian Research. May, 2021 | Pubmed ID: 33971923 DNA Repair in Primordial Follicle Oocytes Following Cisplatin Treatment Journal of Assisted Reproduction and Genetics. Jun, 2021 | Pubmed ID: 33864208 Evaluation of Inflammation and Follicle Depletion During Ovarian Ageing in Mice Scientific Reports. Jan, 2021 | Pubmed ID: 33432051 The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33644037 Comparison of Methods for Quantifying Primordial Follicles in the Mouse Ovary Journal of Ovarian Research. Oct, 2020 | Pubmed ID: 33054849 The PARP Inhibitor, Olaparib, Depletes the Ovarian Reserve in Mice: Implications for Fertility Preservation Human Reproduction (Oxford, England). Aug, 2020 | Pubmed ID: 32604417 Oocytes Can Efficiently Repair DNA Double-strand Breaks to Restore Genetic Integrity and Protect Offspring Health Proceedings of the National Academy of Sciences of the United States of America. 05, 2020 | Pubmed ID: 32381741 Moderate Episodic Prenatal Alcohol Does Not Impact Female Offspring Fertility in Rats Reproduction (Cambridge, England). 05, 2020 | Pubmed ID: 32168471 Do Cancer Therapies Damage the Uterus and Compromise Fertility? Human Reproduction Update. Feb, 2020 | Pubmed ID: 31863097 Evaluation of Mitochondria in Oocytes Following γ-irradiation Scientific Reports. 12, 2019 | Pubmed ID: 31882895 Do BRCA1 and BRCA2 Gene Mutation Carriers Have a Reduced Ovarian Reserve? Protocol for a Prospective Observational Study BMJ Open. 11, 2019 | Pubmed ID: 31772111 Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. 05, 2019 | Pubmed ID: 30657998 Oocytes from Stem Cells Best Practice & Research. Clinical Obstetrics & Gynaecology. Feb, 2019 | Pubmed ID: 30120061 Maternal Low-protein Diet Programmes Low Ovarian Reserve in Offspring Reproduction (Cambridge, England). 10, 2018 | Pubmed ID: 30306601 Methylation of All BRCA1 Copies Predicts Response to the PARP Inhibitor Rucaparib in Ovarian Carcinoma Nature Communications. 09, 2018 | Pubmed ID: 30266954 Multidose 5-Fluorouracil is Highly Toxic to Growing Ovarian Follicles in Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2018 | Pubmed ID: 30085306 Maternal Low-protein Diet Programmes Low Ovarian Reserve in Offspring Reproduction (Cambridge, England). 10, 2018 | Pubmed ID: 29991566 Loss of PUMA Protects the Ovarian Reserve During DNA-damaging Chemotherapy and Preserves Fertility Cell Death & Disease. 05, 2018 | Pubmed ID: 29795269 The Capacity of Oocytes for DNA Repair Cellular and Molecular Life Sciences : CMLS. 08, 2018 | Pubmed ID: 29748894 Dacarbazine Depletes the Ovarian Reserve in Mice and Depletion is Enhanced with Age Scientific Reports. 04, 2018 | Pubmed ID: 29695822 Examination of the Ovotoxicity of 5-fluorouracil in Mice Journal of Assisted Reproduction and Genetics. Jun, 2018 | Pubmed ID: 29589294 The Importance of DNA Repair for Maintaining Oocyte Quality in Response to Anti-cancer Treatments, Environmental Toxins and Maternal Ageing Human Reproduction Update. Mar, 2018 | Pubmed ID: 29377997 The Ovarian Reserve is Depleted During Puberty in a Hormonally Driven Process Dependent on the Pro-apoptotic Protein BMF Cell Death & Disease. 08, 2017 | Pubmed ID: 28771225 BCL2-modifying Factor Promotes Germ Cell Loss During Murine Oogenesis Reproduction (Cambridge, England). May, 2016 | Pubmed ID: 26917450 How Is the Number of Primordial Follicles in the Ovarian Reserve Established? Biology of Reproduction. Nov, 2015 | Pubmed ID: 26423124 Ovarian Reserve Screening: a Scientific and Ethical Analysis Human Reproduction (Oxford, England). Apr, 2015 | Pubmed ID: 25637623 What is the "ovarian Reserve"? Fertility and Sterility. Mar, 2015 | Pubmed ID: 25500021 Dual Roles for Id4 in the Regulation of Estrogen Signaling in the Mammary Gland and Ovary Development (Cambridge, England). Aug, 2014 | Pubmed ID: 25038044 Loss of the Proapoptotic BH3-only Protein BCL-2 Modifying Factor Prolongs the Fertile Life Span in Female Mice Biology of Reproduction. Apr, 2014 | Pubmed ID: 24571986 Molecular Correlates of Platinum Response in Human High-grade Serous Ovarian Cancer Patient-derived Xenografts Molecular Oncology. May, 2014 | Pubmed ID: 24560445 DNA Damage-induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-mediated Induction of Puma and Noxa Molecular Cell. Nov, 2012 | Pubmed ID: 23000175 Cisplatin-induced Primordial Follicle Oocyte Killing and Loss of Fertility Are Not Prevented by Imatinib Nature Medicine. Aug, 2012 | Pubmed ID: 22869179 Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model Meaghan J. Griffiths*1,2, Jordan N. Higgins*1, Fiona L. Cousins3, Lauren R. Alesi1, Amy L. Winship*1, Karla J. Hutt*1 1Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, 2Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, 3The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology, Monash University JoVE 64763 Biología del desarrollo
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model Meaghan J. Griffiths*1,2, Jordan N. Higgins*1, Fiona L. Cousins3, Lauren R. Alesi1, Amy L. Winship*1, Karla J. Hutt*1 1Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, 2Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne, 3The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology, Monash University JoVE 64763 Biología del desarrollo
