Malcolm A. Martin Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases National Institutes of Health Biography Publications Institution JoVE Articles Malcolm A. Martin has not added a biography. If you are Malcolm A. Martin and would like to personalize this page please email our Author Liaison for assistance. Publications Neutralizing Antibodies Induced in Immunized Macaques Recognize the CD4-binding Site on an Occluded-open HIV-1 Envelope Trimer Nature Communications. Feb, 2022 | Pubmed ID: 35136084 Sequential Immunization of Macaques Elicits Heterologous Neutralizing Antibodies Targeting the V3-glycan Patch of HIV-1 Env Science Translational Medicine. Nov, 2021 | Pubmed ID: 34818054 Antibody Elicited by HIV-1 Immunogen Vaccination in Macaques Displaces Env Fusion Peptide and Destroys a Neutralizing Epitope NPJ Vaccines. Oct, 2021 | Pubmed ID: 34697307 Concordance of Immunological Events Between Intrarectal and Intravenous SHIVAD8-EO Infection when Assessed by Fiebig-equivalent Staging The Journal of Clinical Investigation. Sep, 2021 | Pubmed ID: 34623326 Immunotherapy During the Acute SHIV Infection of Macaques Confers Long-term Suppression of Viremia The Journal of Experimental Medicine. Jan, 2021 | Pubmed ID: 32966579 Immunization Expands B Cells Specific to HIV-1 V3 Glycan in Mice and Macaques Nature. Jun, 2019 | Pubmed ID: 31142836 A Single Injection of Crystallizable Fragment Domain-modified Antibodies Elicits Durable Protection from SHIV Infection Nature Medicine. May, 2018 | Pubmed ID: 29662199 Potential of Conventional & Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C & D Infections PLoS Pathogens. Mar, 2018 | Pubmed ID: 29505593 Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1 Cell Host & Microbe. Aug, 2017 | Pubmed ID: 28799906 Early Antibody Therapy Can Induce Long-lasting Immunity to SHIV Nature. Mar, 2017 | Pubmed ID: 28289286 Mapping Polyclonal HIV-1 Antibody Responses Via Next-Generation Neutralization Fingerprinting PLoS Pathogens. Jan, 2017 | Pubmed ID: 28052137 DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV Journal of Immunology (Baltimore, Md. : 1950). Nov, 2016 | Pubmed ID: 27733554 A Single Injection of Anti-HIV-1 Antibodies Protects Against Repeated SHIV Challenges Nature. May, 2016 | Pubmed ID: 27120156 Quality and Quantity of TFH Cells Are Critical for Broad Antibody Development in SHIVAD8 Infection Science Translational Medicine. Jul, 2015 | Pubmed ID: 26223303 The Expression of Functional Vpx During Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells PLoS Pathogens. May, 2015 | Pubmed ID: 25996507 Analysis of Immunoglobulin Transcripts and Hypermutation Following SHIV(AD8) Infection and Protein-plus-adjuvant Immunization Nature Communications. 2015 | Pubmed ID: 25858157 Enhanced HIV-1 Immunotherapy by Commonly Arising Antibodies That Target Virus Escape Variants The Journal of Experimental Medicine. Nov, 2014 | Pubmed ID: 25385756 Passive Transfer of Modest Titers of Potent and Broadly Neutralizing Anti-HIV Monoclonal Antibodies Block SHIV Infection in Macaques The Journal of Experimental Medicine. Sep, 2014 | Pubmed ID: 25155019 Antibody-mediated Immunotherapy of Macaques Chronically Infected with SHIV Suppresses Viraemia Nature. Nov, 2013 | Pubmed ID: 24172896 Emergence of Gp120 V3 Variants Confers Neutralization Resistance in an R5 Simian-human Immunodeficiency Virus-infected Macaque Elite Neutralizer That Targets the N332 Glycan of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Journal of Virology. Aug, 2013 | Pubmed ID: 23720719 Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization Science (New York, N.Y.). May, 2013 | Pubmed ID: 23661761 Most Rhesus Macaques Infected with the CCR5-tropic SHIV(AD8) Generate Cross-reactive Antibodies That Neutralize Multiple HIV-1 Strains Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23129652 Pathogenicity and Mucosal Transmissibility of the R5-tropic Simian/human Immunodeficiency Virus SHIV(AD8) in Rhesus Macaques: Implications for Use in Vaccine Studies Journal of Virology. Aug, 2012 | Pubmed ID: 22647691 Rapid Development of Glycan-specific, Broad, and Potent Anti-HIV-1 Gp120 Neutralizing Antibodies in an R5 SIV/HIV Chimeric Virus Infected Macaque Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22123961 The Simian Immunodeficiency Virus Targets Central Cell Cycle Functions Through Transcriptional Repression in Vivo PloS One. 2011 | Pubmed ID: 22043290 The Acute HIV Infection: Implications for Intervention, Prevention and Development of an Effective AIDS Vaccine Current Opinion in Virology. Sep, 2011 | Pubmed ID: 21909345 Recombination-mediated Changes in Coreceptor Usage Confer an Augmented Pathogenic Phenotype in a Nonhuman Primate Model of HIV-1-induced AIDS Journal of Virology. Oct, 2011 | Pubmed ID: 21813599 Generation of the Pathogenic R5-tropic Simian/human Immunodeficiency Virus SHIVAD8 by Serial Passaging in Rhesus Macaques Journal of Virology. May, 2010 | Pubmed ID: 20147396 Neutralizing Antibody Titers Conferring Protection to Macaques from a Simian/human Immunodeficiency Virus Challenge Using the TZM-bl Assay AIDS Research and Human Retroviruses. Jan, 2010 | Pubmed ID: 20059398 Initiation of Antiretroviral Therapy 48 Hours After Infection with Simian Immunodeficiency Virus Potently Suppresses Acute-phase Viremia and Blocks the Massive Loss of Memory CD4+ T Cells but Fails to Prevent Disease Journal of Virology. Jul, 2009 | Pubmed ID: 19420078 High Frequencies of Resting CD4+ T Cells Containing Integrated Viral DNA Are Found in Rhesus Macaques During Acute Lentivirus Infections Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416840 Importance of the V1/V2 Loop Region of Simian-human Immunodeficiency Virus Envelope Glycoprotein Gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response Journal of Virology. Nov, 2008 | Pubmed ID: 18768967 Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content is Able to Establish Infections in Pig-tailed Macaques Journal of Virology. Oct, 2007 | Pubmed ID: 17670817 Although Macrophage-tropic Simian/human Immunodeficiency Viruses Can Exhibit a Range of Pathogenic Phenotypes, a Majority of Isolates Induce No Clinical Disease in Immunocompetent Macaques Journal of Virology. Oct, 2007 | Pubmed ID: 17626082 The Locus Encoding an Oligomorphic Family of MHC-A Alleles (Mane-A*06/Mamu-A*05) is Present at High Frequency in Several Macaque Species Immunogenetics. Mar, 2007 | Pubmed ID: 17256149 Loss of Naïve Cells Accompanies Memory CD4+ T-cell Depletion During Long-term Progression to AIDS in Simian Immunodeficiency Virus-infected Macaques Journal of Virology. Jan, 2007 | Pubmed ID: 17093193 Generation of HIV-1 Derivatives That Productively Infect Macaque Monkey Lymphoid Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17065315 CD8+ and CD20+ Lymphocytes Cooperate to Control Acute Simian Immunodeficiency Virus/human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys: Modulation by Major Histocompatibility Complex Genotype Journal of Virology. Dec, 2005 | Pubmed ID: 16282488 Resting Naive CD4+ T Cells Are Massively Infected and Eliminated by X4-tropic Simian-human Immunodeficiency Viruses in Macaques Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15911767 Highly Pathogenic SHIVs and SIVs Target Different CD4+ T Cell Subsets in Rhesus Monkeys, Explaining Their Divergent Clinical Courses Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15297611 Pig-tailed Macaques (Macaca Nemestrina) Possess Six MHC-E Families That Are Conserved Among Macaque Species: Implication for Their Binding to Natural Killer Receptor Variants Immunogenetics. Jun, 2004 | Pubmed ID: 15148641 Induction of Disease by a Molecularly Cloned Highly Pathogenic Simian Immunodeficiency Virus/human Immunodeficiency Virus Chimera is Multigenic Journal of Virology. May, 2004 | Pubmed ID: 15113931 Macrophage-tropic Simian/human Immunodeficiency Virus Chimeras Use CXCR4, Not CCR5, for Infections of Rhesus Macaque Peripheral Blood Mononuclear Cells and Alveolar Macrophages Journal of Virology. Dec, 2003 | Pubmed ID: 14645561 Transfer of Neutralizing IgG to Macaques 6 H but Not 24 H After SHIV Infection Confers Sterilizing Protection: Implications for HIV-1 Vaccine Development Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14627745 The Emergence and Characterization of Macrophage-tropic SIV/HIV Chimeric Viruses (SHIVs) Present in CD4+ T Cell-depleted Rhesus Monkeys Journal of Leukocyte Biology. Nov, 2003 | Pubmed ID: 14595005 Early Control of Highly Pathogenic Simian Immunodeficiency Virus/human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys Usually Results in Long-lasting Asymptomatic Clinical Outcomes Journal of Virology. Oct, 2003 | Pubmed ID: 14512533 Characterization of Pig-tailed Macaque Classical MHC Class I Genes: Implications for MHC Evolution and Antigen Presentation in Macaques Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12847257 Control of Viremia and Prevention of Simian-human Immunodeficiency Virus-induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses Plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles Journal of Virology. Jan, 2003 | Pubmed ID: 12502833 Amino Acid Deletions Are Introduced into the V2 Region of Gp120 During Independent Pathogenic Simian Immunodeficiency Virus/HIV Chimeric Virus (SHIV) Infections of Rhesus Monkeys Generating Variants That Are Macrophage Tropic Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12370415 Evolution of a Human Immunodeficiency Virus Type 1 Variant with Enhanced Replication in Pig-tailed Macaque Cells by DNA Shuffling Journal of Virology. Mar, 2002 | Pubmed ID: 11861859 Determination of a Statistically Valid Neutralization Titer in Plasma That Confers Protection Against Simian-human Immunodeficiency Virus Challenge Following Passive Transfer of High-titered Neutralizing Antibodies Journal of Virology. Mar, 2002 | Pubmed ID: 11836389 Rapid and Irreversible CD4+ T-cell Depletion Induced by the Highly Pathogenic Simian/human Immunodeficiency Virus SHIV(DH12R) is Systemic and Synchronous Journal of Virology. Jan, 2002 | Pubmed ID: 11739702 N-linked Glycosylation Sites Adjacent to and Within the V1/V2 and the V3 Loops of Dualtropic Human Immunodeficiency Virus Type 1 Isolate DH12 Gp120 Affect Coreceptor Usage and Cellular Tropism Journal of Virology. Jul, 2001 | Pubmed ID: 11390601 Polyvalent Envelope Glycoprotein Vaccine Elicits a Broader Neutralizing Antibody Response but is Unable to Provide Sterilizing Protection Against Heterologous Simian/human Immunodeficiency Virus Infection in Pigtailed Macaques Journal of Virology. Mar, 2001 | Pubmed ID: 11160726 Macrophage Are the Principal Reservoir and Sustain High Virus Loads in Rhesus Macaques After the Depletion of CD4+ T Cells by a Highly Pathogenic Simian Immunodeficiency Virus/HIV Type 1 Chimera (SHIV): Implications for HIV-1 Infections of Humans Proceedings of the National Academy of Sciences of the United States of America. Jan, 2001 | Pubmed ID: 11136236 Identification of Gp120 Regions Targeted by a Highly Potent Neutralizing Antiserum Elicited in a Chimpanzee Inoculated with a Primary Human Immunodeficiency Virus Type 1 Isolate Journal of Virology. Oct, 2000 | Pubmed ID: 11000249 Short- and Long-term Clinical Outcomes in Rhesus Monkeys Inoculated with a Highly Pathogenic Chimeric Simian/human Immunodeficiency Virus Journal of Virology. Aug, 2000 | Pubmed ID: 10888632 Transcriptional Activation of the Integrated Chromatin-associated Human Immunodeficiency Virus Type 1 Promoter Molecular and Cellular Biology. May, 1998 | Pubmed ID: 9566873 Identification of Determinants on a Dualtropic Human Immunodeficiency Virus Type 1 Envelope Glycoprotein That Confer Usage of CXCR4 Journal of Virology. Mar, 1998 | Pubmed ID: 9499115 Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/human Immunodeficiency Virus During Primary Infections of Rhesus Macaques Journal of Virology. Jan, 1998 | Pubmed ID: 9420212 Common Methionine-tryptic Peptides Near the Amino-terminal End of Primate Papovavirus Tumor Antigens Proceedings of the National Academy of Sciences of the United States of America. Mar, 1978 | Pubmed ID: 206886 Reassortment of Simian Virus 40 DNA During Serial Undiluted Passage Journal of Virology. Oct, 1973 | Pubmed ID: 4359951 In Vitro Transcription of the Viral-specific Sequences Present in the Chromatin of Cells Transformed by Simian Virus 40 Proceedings of the National Academy of Sciences of the United States of America. Dec, 1973 | Pubmed ID: 4357875 A General Method of Gene Isolation Proceedings of the National Academy of Sciences of the United States of America. Jun, 1973 | Pubmed ID: 4352649 Patterns of Simian Virus 40 Deoxyribonucleic Acid Transcription. II. In Transformed Cells Journal of Virology. Jan, 1973 | Pubmed ID: 4346281 Patterns of Simian Virus 40 DNA Transcription After Acute Infection of Permissive and Nonpermissive Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 1972 | Pubmed ID: 4340164 Detection and Quantitation of Simian Virus 40 Genetic Material in Abortively Transformed BALB-3T3 Clones (mice-diploid Cells-virus Equivalents) Proceedings of the National Academy of Sciences of the United States of America. Jan, 1972 | Pubmed ID: 4333038 Physical and Biochemical Properties of Progressive Pneumonia Virus Journal of Virology. Oct, 1971 | Pubmed ID: 4108574 Sedimentation Properties of Simian Virus 40-specific Ribonucleic Acid Present in Green Monkey Cells During Productive Infection and in Mouse Cells Undergoing Abortive Infection Journal of Virology. Oct, 1970 | Pubmed ID: 5497892 SV40 Gene Activity During Lytic Infection and in a Series of SV40 Transformed Mouse Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 1969 | Pubmed ID: 4318346 Gene Editing of Primary Rhesus Macaque B Cells Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Inmunología e infección
Gene Editing of Primary Rhesus Macaque B Cells Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Inmunología e infección
