Aneo Chem-Tech Co., Ltd 1 article published in JoVE Chemistry Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3 Lingling Zhang1, Weicai Xue1, Quanwei Li1, Hui Liu1, Dexun Xie1 1Aneo Chem-Tech Co., Ltd Here, we present a protocol for the scaled-up synthesis of the intermediate tert-butyl (5-toluenesulfonyl-5h-pyrrole [2,3-b] pyrazine-2-yl) carbamate (ACT051-3) of Upatinib.