SSNHL Statistical Output

This output was generated from the prepared individual-level CSV datasets. Source tables were used as targets for structure, counts, and summary statistics. Native SPV output was not created in this environment because PSPP/SPSS was not available.

Audit summary

status count
PASS 55

Table 1

indicator control_group combination_therapy_group statistic_value p_value test
Age (years) 52.38 +/- 5.84 53.16 +/- 5.02 t = 0.716 0.476 Independent-samples t test
Time from onset to visit (days) 4.28 +/- 0.53 4.42 +/- 0.51 t = 1.347 0.181 Independent-samples t test
Baseline PTA-4 (dB HL) 69.45 +/- 7.64 70.16 +/- 7.32 t = 0.474 0.636 Independent-samples t test
Sex (male/female, n, %) 27 (54 %) / 23 (46 %) 25 (50 %) / 25 (50 %) chi-square = 0.160 0.689 Chi-square test
Side of affected ear (left/right, n, %) 26 (52 %) / 24 (48 %) 23 (46 %) / 27 (54 %) chi-square = 0.360 0.548 Chi-square test
History of hypertension (n, %) 11 (22 %) 9 (18 %) chi-square = 0.250 0.617 Chi-square test

Table 2

time_point control_group combination_therapy_group mean_difference_95ci t_value p_value cohens_d
Baseline 69.45 +/- 7.64 70.16 +/- 7.32 0.71 (-2.26 to 3.68) 0.474 0.636 0.095
Day 10 63.21 +/- 7.02 60.85 +/- 6.28 -2.36 (-5.00 to 0.28) 1.772 0.080 0.354
Day 30 57.44 +/- 6.51 55.12 +/- 5.94 -2.32 (-4.79 to 0.15) 1.861 0.066 0.372
Day 90 52.36 +/- 6.07 48.79 +/- 5.66 -3.57 (-5.90 to -1.24) 3.041 0.003 0.608
Group x time interaction F = 19.535, p = <0.001 NaN NaN NaN NaN NaN

Table 3

hearing_grade time_point control_group_n_percent combination_therapy_group_n_percent statistic_value p_value test
Mild NaN NaN NaN NaN NaN NaN
NaN Baseline 3 (6.0 %) 2 (4.0 %) chi-square = 0.211 0.646 Chi-square test
NaN Day 90 8 (16.0 %) 15 (30.0 %) chi-square = 2.767 0.096 Chi-square test
Moderate NaN NaN NaN NaN NaN NaN
NaN Baseline 12 (24.0 %) 9 (18.0 %) chi-square = 0.542 0.461 Chi-square test
NaN Day 90 21 (42.0 %) 23 (46.0 %) chi-square = 0.162 0.687 Chi-square test
Severe NaN NaN NaN NaN NaN NaN
NaN Baseline 21 (42.0 %) 26 (52.0 %) chi-square = 1.004 0.316 Chi-square test
NaN Day 90 15 (30.0 %) 9 (18.0 %) chi-square = 1.974 0.160 Chi-square test
Profound NaN NaN NaN NaN NaN NaN
NaN Baseline 14 (28.0 %) 13 (26.0 %) chi-square = 0.051 0.822 Chi-square test
NaN Day 90 6 (12.0 %) 3 (6.0 %) chi-square = 1.099 0.295 Chi-square test

Table 4

dimension time_point control_group combination_therapy_group mean_difference_95ci t_value p_value cohens_d
PF Baseline 55.27 +/- 4.95 54.62 +/- 5.14 -0.65 (-2.65 to 1.35) 0.644 0.521 0.129
NaN Day 30 62.13 +/- 5.11 66.59 +/- 5.43 4.46 (2.37 to 6.55) 4.229 <0.001 0.846
NaN Day 90 68.45 +/- 5.77 74.51 +/- 6.09 6.06 (3.71 to 8.41) 5.108 <0.001 1.022
NaN Group x time interaction F = 6.951, p = <0.001 NaN NaN NaN NaN NaN
RP Baseline 50.96 +/- 6.28 51.44 +/- 6.01 0.48 (-1.96 to 2.92) 0.390 0.698 0.078
NaN Day 30 58.27 +/- 5.94 60.69 +/- 6.23 2.42 (0.00 to 4.84) 1.988 0.050 0.398
NaN Day 90 63.41 +/- 6.32 68.15 +/- 5.98 4.74 (2.30 to 7.18) 3.851 <0.001 0.770
NaN Group x time interaction F = 3.770, p = 0.012 NaN NaN NaN NaN NaN
BP Baseline 57.83 +/- 4.89 58.64 +/- 5.27 0.81 (-1.21 to 2.83) 0.796 0.428 0.159
NaN Day 30 63.25 +/- 5.24 66.16 +/- 5.48 2.91 (0.78 to 5.04) 2.714 0.008 0.543
NaN Day 90 68.42 +/- 5.93 72.57 +/- 5.86 4.15 (1.81 to 6.49) 3.520 <0.001 0.704
NaN Group x time interaction F = 3.258, p = 0.023 NaN NaN NaN NaN NaN
GH Baseline 52.41 +/- 5.01 53.26 +/- 5.57 0.85 (-1.25 to 2.95) 0.803 0.424 0.161
NaN Day 30 59.07 +/- 5.18 61.42 +/- 5.44 2.35 (0.24 to 4.46) 2.212 0.029 0.442
NaN Day 90 64.69 +/- 5.35 69.45 +/- 5.87 4.76 (2.53 to 6.99) 4.238 <0.001 0.848
NaN Group x time interaction F = 5.316, p = 0.002 NaN NaN NaN NaN NaN
VT Baseline 54.39 +/- 4.96 53.72 +/- 4.64 -0.67 (-2.58 to 1.24) 0.698 0.487 0.140
NaN Day 30 60.11 +/- 5.45 64.38 +/- 5.22 4.27 (2.15 to 6.39) 4.000 <0.001 0.800
NaN Day 90 66.24 +/- 5.67 71.56 +/- 6.18 5.32 (2.97 to 7.67) 4.485 <0.001 0.897
NaN Group x time interaction F = 5.665, p = <0.001 NaN NaN NaN NaN NaN
SF Baseline 58.61 +/- 5.22 59.38 +/- 4.88 0.77 (-1.24 to 2.78) 0.762 0.448 0.152
NaN Day 30 63.72 +/- 5.35 67.21 +/- 5.43 3.49 (1.35 to 5.63) 3.238 0.002 0.648
NaN Day 90 69.08 +/- 5.74 73.48 +/- 6.03 4.40 (2.06 to 6.74) 3.736 <0.001 0.747
NaN Group x time interaction F = 3.900, p = 0.010 NaN NaN NaN NaN NaN
RE Baseline 55.02 +/- 5.41 55.67 +/- 5.84 0.65 (-1.58 to 2.88) 0.578 0.565 0.116
NaN Day 30 61.35 +/- 5.52 64.83 +/- 5.95 3.48 (1.20 to 5.76) 3.032 0.003 0.606
NaN Day 90 66.78 +/- 5.64 71.84 +/- 5.32 5.06 (2.88 to 7.24) 4.614 <0.001 0.923
NaN Group x time interaction F = 7.095, p = <0.001 NaN NaN NaN NaN NaN
MH Baseline 56.18 +/- 5.06 55.72 +/- 5.23 -0.46 (-2.50 to 1.58) 0.447 0.656 0.089
NaN Day 30 62.09 +/- 5.51 65.36 +/- 5.88 3.27 (1.01 to 5.53) 2.870 0.005 0.574
NaN Day 90 67.42 +/- 5.81 72.39 +/- 6.02 4.97 (2.62 to 7.32) 4.201 <0.001 0.840
NaN Group x time interaction F = 4.237, p = 0.006 NaN NaN NaN NaN NaN

Table 5

time_point control_group combination_therapy_group mean_difference_95ci t_value p_value cohens_d
Baseline 72.63 +/- 6.85 71.84 +/- 6.42 -0.79 (-3.42 to 1.85) 0.595 0.553 0.119
Day 10 64.58 +/- 6.01 60.23 +/- 6.14 -4.35 (-6.76 to -1.94) 3.579 <0.001 0.716
Day 30 56.42 +/- 5.58 51.37 +/- 5.44 -5.05 (-7.24 to -2.86) 4.583 <0.001 0.917
Day 90 48.06 +/- 5.12 41.12 +/- 4.68 -6.94 (-8.89 to -4.99) 7.074 <0.001 1.415
Group x time interaction F = 18.105, p = <0.001 NaN NaN NaN NaN NaN

Table 6

adverse_reaction_type control_group_n_percent combination_therapy_group_n_percent statistic_value p_value test
Headache 6 (12.0 %) 4 (8.0 %) chi-square = 0.444 0.505 Chi-square test
Dizziness 4 (8.0 %) 5 (10.0 %) chi-square = 0.122 0.727 Chi-square test
Nausea 5 (10.0 %) 3 (6.0 %) chi-square = 0.543 0.461 Chi-square test
Rash 2 (4.0 %) 1 (2.0 %) chi-square = 0.344 0.558 Chi-square test
Blood pressure fluctuation 3 (6.0 %) 1 (2.0 %) chi-square = 1.042 0.307 Chi-square test
Other serious adverse event 1 (2.0 %) 0 (0.0 %) Fisher 1.000 Fisher exact test

File status

0 1
SSNHL_analysis_dataset.csv Created
SSNHL_pta4_long.csv Created
SSNHL_sf36_long.csv Created
SSNHL_hhia_long.csv Created
SSNHL_adverse_event_flags.csv Created
SSNHL_analysis_syntax.sps Created
SSNHL_statistical_output.spv Not created: PSPP/SPSS not available in this environment