﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Sexton, F
   Healy, D
   Keelan, S
   Alazzawi, M
   Naughton, P
AF Sexton, Fiona
   Healy, Donagh
   Keelan, Stephen
   Alazzawi, Mohammed
   Naughton, Peter
TI A systematic review and meta-analysis comparing the effectiveness of
   negative-pressure wound therapy to standard therapy in the prevention of
   complications after vascular surgery
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Negative pressure wound therapy; Negative pressure dressing; Negative
   pressure wound dressing; Vascular surgery; Peripheral artery disease;
   Peripheral vascular disease
ID INCISION; TRIAL
AB Introduction: Negative pressure wound therapy (NPWT) dressings reduce wound complications in a variety of settings but it is unclear whether they reduce groin wound complications in closed incisions after vascular surgery. Therefore, we performed a systematic review and meta-analysis.
   Methods: Randomised controlled trials on the use of negative pressure wound dressings on closed groin incisions following vascular surgery were identified from an electronic search of abstract databases, conference proceedings and article reference lists. The primary outcome was surgical site infection (SSI) and secondary outcomes were seromas, readmissions within 30 days postoperatively, reoperations and length of stay.
   Results: 7 exploratory trials involving 935 incisions and an unclear number of patients were identified. 4 trials yielded primary outcome results that favoured NPWT. Meta-analysis found that NPWT dressings reduced SSIs (RR 0.47; 95%CI 0.31-0.70; 3 studies, 422 patients). No other meta-analyses could be performed.
   Conclusion: NPWT dressings are a promising intervention that may reduce the incidence of groin wound complications following vascular surgery. However, further large-scale well-designed studies are needed before NPWT dressings can become the standard of care.
C1 [Sexton, Fiona; Healy, Donagh; Keelan, Stephen; Alazzawi, Mohammed; Naughton, Peter] Beaumont Hosp, Dept Vasc Surg, Dublin, Ireland.
C3 Beaumont Hospital Dublin
RP Healy, D (通讯作者)，Beaumont Hosp, Dept Vasc Surg, Dublin, Ireland.
EM donaghhealy@rcsi.com
OI Healy, Donagh/0000-0002-4046-5457; Keelan, Stephen/0000-0002-3632-5128
CR [Anonymous], ANN SURG
   Banwell Paul, 2006, J Tissue Viability, V16, P16
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
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NR 17
TC 31
Z9 34
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD APR
PY 2020
VL 76
BP 94
EP 100
DI 10.1016/j.ijsu.2020.02.037
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KY5YP
UT WOS:000522649400033
PM 32142903
DA 2026-07-24
ER

PT J
AU Veerasubramanian, PK
   Joe, VC
   Liu, WYF
   Downing, TL
AF Veerasubramanian, Praveen Krishna
   Joe, Victor C.
   Liu, Wendy F.
   Downing, Timothy L.
TI Characterization of Macrophage and Cytokine Interactions with
   Biomaterials Used in Negative-Pressure Wound Therapy
SO BIOENGINEERING-BASEL
LA English
DT Article
DE macrophages; negative-pressure wound therapy; wound healing; wound
   dressings; cell-material interactions
AB Macrophages are innate immune cells that help wounds heal. Here, we study the potential immunomodulatory effects of negative-pressure wound therapy (NPWT) materials on the macrophage inflammatory response. We compared the effects of two materials, Granufoam (TM) (GF) and Veraflo Cleanse (TM) (VC), on macrophage function in vitro. We find that both materials cause reduced expression of inflammatory genes, such as TNF and IL1B, in human macrophages stimulated with bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN gamma). Relative to adherent glass control surfaces, VC discourages macrophage adhesion and spreading, and may potentially sequester LPS/IFN gamma and cytokines that the cells produce. GF, on the other hand, was less suppressive of inflammation, supported macrophage adhesion and spreading better than VC, and sequestered lesser quantities of LPS/IFN gamma in comparison to VC. The control dressing material cotton gauze (CT) was also immunosuppressive, capable of TNF-alpha retention and LPS/IFN gamma sequestration. Our findings suggest that NPWT material interactions with cells, as well as soluble factors including cytokines and LPS, can modulate the immune response, independent of vacuum application. We have also established methodological strategies for studying NPWT materials and reveal the potential utility of cell-based in vitro studies for elucidating biological effects of NPWT materials.
C1 [Veerasubramanian, Praveen Krishna; Liu, Wendy F.; Downing, Timothy L.] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA.
   [Veerasubramanian, Praveen Krishna; Liu, Wendy F.; Downing, Timothy L.] Univ Calif Irvine, UCI Edwards Lifesci Fdn Cardiovasc Innovat & Res, Irvine, CA 92697 USA.
   [Joe, Victor C.] Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Dept Chem & Biomol Engn, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA.
   [Liu, Wendy F.] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA.
   [Downing, Timothy L.] Univ Calif Irvine, NSF Simons Ctr Multiscale Cell Fate Res, Irvine, CA 92697 USA.
   [Downing, Timothy L.] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Liu, WYF; Downing, TL (通讯作者)，Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA.; Liu, WYF; Downing, TL (通讯作者)，Univ Calif Irvine, UCI Edwards Lifesci Fdn Cardiovasc Innovat & Res, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Dept Chem & Biomol Engn, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Inst Immunol, Irvine, CA 92697 USA.; Liu, WYF (通讯作者)，Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA.; Downing, TL (通讯作者)，Univ Calif Irvine, NSF Simons Ctr Multiscale Cell Fate Res, Irvine, CA 92697 USA.; Downing, TL (通讯作者)，Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA.
EM pveerasu@uci.edu; vcjoe@hs.uci.edu; wendy.liu@uci.edu;
   tim.downing@uci.edu
RI ; Veerasubramanian, Praveen Krishna/KIJ-2060-2024
OI Liu, Wendy/0000-0002-8904-7643; Veerasubramanian, Praveen
   Krishna/0000-0001-8204-088X; Downing, Timothy/0000-0002-5197-3684
FU National Institutes of Health (NIH) National Institute of Allergy and
   Infectious Disease (NIAID) [R01AI151301]; NIH National Institute of
   Biomedical Imaging and Bioengineering (NIBIB) [R21EB027840-01]; NIH New
   Innovator Award (DP2) [DP2CA250382-01]; National Science Foundation
   (NSF) grant [DMS1763272]; Simons Foundation [594598 QN];  [DMR-2011967];
    [CHE-0802913];  [1S10OD025064-01A1]
FX This work was supported by National Institutes of Health (NIH) National
   Institute of Allergy and Infectious Disease (NIAID) Grant R01AI151301 to
   W.F.L, NIH National Institute of Biomedical Imaging and Bioengineering
   (NIBIB) Grant R21EB027840-01 to T.L.D and W.F.L, and NIH New Innovator
   Award (DP2) Grant DP2CA250382-01, a National Science Foundation (NSF)
   grant (DMS1763272) and a grant from the Simons Foundation (594598 QN) to
   T.L.D.
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NR 35
TC 5
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-5354
J9 BIOENGINEERING-BASEL
JI Bioengineering-Basel
PD JAN
PY 2022
VL 9
IS 1
AR 2
DI 10.3390/bioengineering9010002
PG 14
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA YO7IJ
UT WOS:000748110000001
PM 35049711
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU González-Muñoz, A
   Vallejo-Soto, JC
   Barragán-Pinilla, JD
   Pesce, A
   Ramírez-Giraldo, C
AF Gonzalez-Munoz, Alejandro
   Vallejo-Soto, Juan Carlos
   Barragan-Pinilla, Juan Diego
   Pesce, Antonio
   Ramirez-Giraldo, Camilo
TI Factors related to successful mesh salvage with negative pressure wound
   therapy: a retrospective cohort study
SO HERNIA
LA English
DT Article
DE Hernia; Mesh infection; Wound infection; Mesh salvage; Negative pressure
   wound therapy; NPWT
ID EPIDEMIOLOGY; PREDICTORS; INFECTION
AB BackgroundMesh salvage using negative pressure wound therapy (NPWT) in cases of mesh infection following hernia repair has emerged as an alternative to early mesh removal. However, the factors related to the success or failure of mesh salvage with NPWT remain unclear.MethodsThis retrospective cohort study included 61 patients with mesh infections after hernia repair treated with NPWT between 2018 and 2024. We analyzed demographic, clinical, and surgical variables, as well as the bacterial spectrum and antimicrobial susceptibility. A binary logistic regression model was used to identify factors associated with NPWT failure, defined as the need for mesh removal.ResultsMesh salvage was successful in 80.3% of cases. Active smoking was significantly associated with NPWT failure (OR = 7.82, CI 95% 1.05-64.8; p = 0.044). Other factors, such as age, body mass index, Charlson comorbidity index, mesh type, and mesh position, were not significantly related to failure. Most infections were caused by Staphylococcus aureus (24.6%) and Escherichia coli (22.9%).ConclusionsNPWT is an effective method for salvaging infected meshes, with a high success rate. Active smoking was identified as a risk factor for NPWT failure, highlighting the need for early identification of patients who may benefit from alternative approaches. Further studies are required to develop predictive models for NPWT success in mesh salvage.
C1 [Gonzalez-Munoz, Alejandro; Ramirez-Giraldo, Camilo] Hosp Univ Mayor Mederi, Bogota, Colombia.
   [Gonzalez-Munoz, Alejandro; Vallejo-Soto, Juan Carlos; Barragan-Pinilla, Juan Diego; Ramirez-Giraldo, Camilo] Univ Rosario, Bogota, Colombia.
   [Pesce, Antonio] Univ Ferrara, Dept Surg, Azienda Unita Sanit Locale Ferrara, Via Valle Oppio 2, I-44023 Lagosanto, FE, Italy.
C3 Universidad del Rosario; University of Ferrara
RP Ramírez-Giraldo, C (通讯作者)，Hosp Univ Mayor Mederi, Bogota, Colombia.; Ramírez-Giraldo, C (通讯作者)，Univ Rosario, Bogota, Colombia.
EM ramirezgiraldocamilo@gmail.com
RI Ramírez-Giraldo, Camilo/LRV-0499-2024; PESCE, ANTONIO/G-4536-2017
OI Ramírez-Giraldo, Camilo/0000-0002-1929-2299; PESCE,
   ANTONIO/0000-0002-7560-551X; Vallejo-Soto, Juan
   Carlos/0009-0006-1950-194X; Gonzalez Muñoz,
   Alejandro/0000-0003-3890-3726
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Bueno-Lledó J, 2017, AM J SURG, V213, P50, DOI 10.1016/j.amjsurg.2016.03.007
   Gao JR, 2021, J ADV NURS, V77, P3980, DOI 10.1111/jan.14876
   Glass GE, 2017, J PLAST RECONSTR AES, V70, P1028, DOI 10.1016/j.bjps.2017.05.027
   Gossetti F, 2019, HERNIA, V23, P699, DOI 10.1007/s10029-019-01905-z
   Hajibandeh S, 2023, AM SURGEON, V89, P4344, DOI 10.1177/00031348221109816
   Hom DB, 2023, FACIAL PLAST SURG CL, V31, P171, DOI 10.1016/j.fsc.2023.01.002
   Li JS, 2022, ANZ J SURG, V92, P2448, DOI 10.1111/ans.18040
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   Sorensen LT, 2012, ANN SURG, V255, P1069, DOI 10.1097/SLA.0b013e31824f632d
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NR 21
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC 4
PY 2024
VL 29
IS 1
AR 42
DI 10.1007/s10029-024-03233-3
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P6Q7H
UT WOS:001379136200001
PM 39633022
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Téot, L
   Boissiere, F
   Fluieraru, S
AF Teot, Luc
   Boissiere, Florian
   Fluieraru, Sergiu
TI Novel foam dressing using negative pressure wound therapy with
   instillation to remove thick exudate
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Devitalised tissue; Fibrinous tissue; Instillation; Negative pressure
   wound therapy; Wound cleansing
ID SYSTEM; SALINE; CARE
AB We describe our experience with a novel foam dressing architecture in tandem with negative pressure wound therapy and instillation (NPWTi-d) for removing viscous wound exudate and infectious materials. A retrospective review was conducted of the outcomes of 21 patients who received NPWTi-d using a reticulated open cell foam instillation dressing with through holes (ROCF-CC) designed to facilitate the removal of thick wound exudate and infectious materials. NPWTi-d with ROCF-CC was used to treat large complex chronic wounds with viscous wound exudate that contained substantial areas of devitalised tissue. Debridement was performed as appropriate or available. NPWTi-d with ROCF-CC assisted in loosening, solubilising and detaching viscous exudate, dry fibrin, wet slough and other infectious materials. Percent surface area of black non-viable tissue and yellow fibrinous slough was reduced to10% in 18/21 (857%) and 12/21 (571%) wounds, respectively, after an average of 1-3 applications (3-9 days) of NPWTi-d with ROCF-CC. Preliminary evidence suggests that adjunctive use of NPWTi-d with ROCF-CC may help clean large, complex wounds when complete surgical debridement is not possible or appropriate and/or when areas of slough and non-viable tissue remain present on the wound surface.
C1 [Teot, Luc; Boissiere, Florian; Fluieraru, Sergiu] Montpellier Univ Hosp, Dept Wound Healing, Burns Unit Plast Surg, 395 Ave Doeyn Giraud, F-34295 Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier
RP Téot, L (通讯作者)，Montpellier Univ Hosp, Dept Wound Healing, Burns Unit Plast Surg, 395 Ave Doeyn Giraud, F-34295 Montpellier, France.
EM l-teot@chu-montpellier.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Gabriel Allen, 2014, Eplasty, V14, pe41
   Goss SG, 2014, J AM COLL CLIN WOUND, V4, P74, DOI DOI 10.1016/J.JCCW.2014.02.001
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
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   Wolvos T, 2013, WOUNDS, V25, P75
NR 17
TC 68
Z9 86
U1 2
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2017
VL 14
IS 5
BP 842
EP 848
DI 10.1111/iwj.12719
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FI3ME
UT WOS:000411865700016
PM 28244217
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Andrabi, SIH
   Ahmad, J
AF Andrabi, Syed Imran Hussain
   Ahmad, Jawad
TI Negative pressure therapy for laparotomy wounds - A word of caution
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
AB Negative pressure wound therapy (NPWT) is being used for the management of laparotomy wounds. The device applies subatmospheric pressure to the open abdominal wounds. We suggest a modification in its application to prevent a leak from the bowel.
C1 Royal Victoria Hosp, Dept Surg, Belfast BT12 6BA, Antrim, North Ireland.
RP Andrabi, SIH (通讯作者)，73 Sicily Pk, Belfast BT10 0AN, Antrim, North Ireland.
EM imranandrabi@gmail.com
RI Indrabi, Dr Syed/AAX-4352-2021
CR Morykwas M J., 1997, J South Orthop Assoc, V6, P284
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Smith PM, 1997, PHOTOGRAMM ENG REM S, V63, P12
NR 3
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1071-5754
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2007
VL 34
IS 4
BP 425
EP 427
DI 10.1097/01.WON.0000281660.99957.79
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 192HY
UT WOS:000248193100011
PM 17667090
DA 2026-07-24
ER

PT J
AU Körber, A
   Franckson, T
   Grabbe, S
   Dissemond, J
AF Koerber, A.
   Franckson, T.
   Grabbe, S.
   Dissemond, J.
TI Vacuum assisted closure device improves the take of mesh grafts in
   chronic leg ulcer patients
SO DERMATOLOGY
LA English
DT Article
DE vacuum assisted closure; mesh graft; chronic leg ulcer
AB Background: Vacuum assisted closure (VAC) is established in the management of acute and chronic wounds. In recent years, few data have been published concerning VAC therapy after skin graft transplantation. Objectives: The aim of this study was to determine whether postoperative VAC helps assist closure of mesh grafts in chronic leg ulcer patients. Patients/Methods: We report a consecutive case series of 54 patients with chronic leg ulcers who received a total of 74 mesh grafts. A postoperative VAC therapy was performed in 28 mesh grafts, and 46 mesh grafts were treated with standard gauze therapy. Results: In the VAC group, 92.9% of grafts showed complete healing, compared to 67.4% in the control group without postoperative VAC therapy. Differential analysis revealed a negative correlation of the take rate in patients over 70 years of age or in patients suffering from diabetes mellitus or dermatoliposclerosis. Particularly patients with diabetes mellitus and of greater age exhibited improved take rates, both 100%, in the VAC group compared to 50 and 62%, respectively. Conclusion: The results of our retrospective study demonstrate for the first time the significant benefit of VAC therapy after skin grafting in chronic leg ulcer patients as evaluated in a clinical trial. Copyright (c) 2008 S. Karger AG, Basel.
C1 [Koerber, A.; Franckson, T.; Grabbe, S.; Dissemond, J.] Essen Univ Sch Med, Dept Dermatol, Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (通讯作者)，Univ Sch Med, Dept Dermatol, Hufelandstr 55, DE-45122 Essen, Germany.
EM joachimdissemond@hotmail.com
RI Dissemond, Joachim/AFG-0691-2022; Grabe, Stephan/AAJ-4578-2021
CR Ahnlide I, 2000, ACTA DERM-VENEREOL, V80, P28
   Antony S, 2004, J NATL MED ASSOC, V96, P1073
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NR 42
TC 51
Z9 58
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PY 2008
VL 216
IS 3
BP 250
EP 256
DI 10.1159/000112937
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 254ML
UT WOS:000252590600014
PM 18204263
DA 2026-07-24
ER

PT J
AU Demir, M
   Yagmur, I
   Kati, B
   Pelit, ES
   Tunçekin, A
   Ciftçi, H
AF Demir, Mehmet
   Yagmur, Ismail
   Kati, Bulent
   Pelit, Eyyup Sabri
   Tuncekin, Adem
   Ciftci, Halil
TI Evaluation of the effectiveness of vacuum-assisted closure in the
   treatment of Fournier gangrene
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Fournier gangrene; Debridement; Vacuum-assisted closure; Wound therapy;
   Mortality
ID PROGNOSTIC-FACTORS; WOUND THERAPY; OUTCOMES; EXPERIENCE; MANAGEMENT
AB Background and objective: To evaluate the effectiveness of vacuum-assisted closure (VAC) in the treatment of Fournier gangrene (FG). Material and methods: Forty-eight male patients treated for Fournier gangrene were included in the study. The patients were divided into two groups (Group I: conventional dressing, Group II: VAC therapy). Characteristics of the patients, laboratory parameters, number of debridement procedures, daily number of dressings, visual analogue scale (VAS) during dressing, analgesic requirement, colostomy requirement, time from the first debridement to wound closure, wound closure method, length of hospital stay, and mortality rates were compared. Results: Group I comprised 33 patients and Group II comprised 15 patients. The number of dressings, VAS score and daily analgesic requirement were statistically significantly lower in Group II (p 0.05) than in Group I. The number of debridement procedures, colostomy requirement, orchiectomy rate, time from first debridement to wound closure, length of hospital stay, wound closure method and mortality rate were similar between these two groups (p 0.05). Conclusion: The clinical results of conventional dressing and VAC therapy were similar for treating FG. VAC therapy is an effective postoperative wound care method that offers less requirement for dressing changes, less pain, less analgesic requirement and more patient satisfaction compared to conventional dressing.
C1 [Demir, Mehmet; Yagmur, Ismail; Kati, Bulent; Pelit, Eyyup Sabri; Tuncekin, Adem; Ciftci, Halil] Harran Univ, Dept Urol, TR-63500 Sanliurfa, Turkey.
C3 Harran University
RP Demir, M (通讯作者)，Harran Univ, Dept Urol, TR-63500 Sanliurfa, Turkey.
EM drdemir02@gmail.com
RI Tunçekin, Adem/HCH-8358-2022; yağmur, ismail/ABF-7274-2020;
   /ABF-3298-2020; /ABI-1129-2020; Kati, Bulent/AGQ-3954-2022; Demir,
   Mehmet/ABF-4150-2020
OI Tunçekin, Adem/0000-0001-9951-2556; 
CR BARKEL DC, 1986, AM SURGEON, V52, P395
   Chawla SN, 2003, EUR UROL, V43, P572, DOI 10.1016/S0302-2838(03)00102-7
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NR 28
TC 0
Z9 0
U1 0
U2 2
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD SEP
PY 2021
VL 17
IS 4
BP 304
EP 309
DI 10.31083/jomh.2021.089
EA AUG 2021
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WD5UM
UT WOS:000699929200001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lozano-Balderas, G
   Ruiz-Velasco-Santacruz, A
   Díaz-Elizondo, JA
   Gómez-Navarro, JA
   Flores-Villalba, E
AF Lozano-Balderas, Gerardo
   Ruiz-Velasco-Santacruz, Alejandro
   Antonio Diaz-Elizondo, Jose
   Antonio Gomez-Navarro, Juan
   Flores-Villalba, Eduardo
TI Surgical Site Infection Rate Drops to 0% Using a Vacuum-Assisted Closure
   in Contaminated/Dirty Infected Laparotomy Wounds
SO AMERICAN SURGEON
LA English
DT Article
ID NEGATIVE-PRESSURE THERAPY; PRIMARY SKIN CLOSURE; OPEN ABDOMEN;
   INCISIONS; HERNIA
AB Wound site infections increase costs, hospital stay, morbidity, and mortality. Techniques used for wounds management after laparotomy are primary, delayed primary, and vacuum-assisted closures. The objective of this study is to compare infection rates between those techniques in contaminated and dirty/ infected wounds. Eighty-one laparotomized patients with Class III or IV surgical wounds were enrolled in a three-arm randomized prospective study. Patients were allocated to each group with the software Research Randomizer (R) (Urbaniak, G. C.,& Plous, S., Version 4.0). Presence of infectionwas determined by a certified board physician according to Centers forDisease Control's Criteria for Defining a Surgical Site Infection. Twenty-seven patients received primary closure, 29 delayed primary closure, and 25 vacuum-assisted closure, with no exclusions for analysis. Surgical site infection was present in 10 (37%) patients treated with primary closure, 5 (17%) with primary delayed closure, and 0 (0%) patients receiving vacuum-assisted closure. Statistical significance was found between infection rates of the vacuum-assisted group and the other two groups. No significant difference was found between the primary and primary delayed closure groups. The infection rate in contaminated/dirty-infected laparotomy wounds decreases from37 and 17 per cent with a primary and delayed primary closures, respectively, to 0 per cent with vacuum-assisted systems.
C1 [Lozano-Balderas, Gerardo; Ruiz-Velasco-Santacruz, Alejandro; Antonio Diaz-Elizondo, Jose; Antonio Gomez-Navarro, Juan; Flores-Villalba, Eduardo] Tecnol Monterrey, Escuela Med, Batallon San Patricio 112 Piso 1 Ote Col Real San, San Pedro Garza Garcia 66278, NL, Mexico.
C3 Tecnologico de Monterrey
RP Flores-Villalba, E (通讯作者)，Tecnol Monterrey, Escuela Med, Batallon San Patricio 112 Piso 1 Ote Col Real San, San Pedro Garza Garcia 66278, NL, Mexico.
EM eduardofloresvillalba@itesm.mx
RI Flores-Villalba, Eduardo/U-2936-2018; Diaz Elizondo, Jose
   Antonio/ABW-9848-2022
OI Flores-Villalba, Eduardo/0000-0002-6048-5957; Lozano-Balderas,
   Gerardo/0000-0002-9074-8973; Diaz Elizondo, Jose
   Antonio/0000-0002-7441-034X; Ruiz-Velasco-Santacruz,
   Alejano/0000-0002-2398-2268
CR Anthony T, 2000, WORLD J SURG, V24, P95, DOI 10.1007/s002689910018
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NR 18
TC 31
Z9 34
U1 0
U2 6
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAY
PY 2017
VL 83
IS 5
BP 512
EP 514
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EV7RC
UT WOS:000401976800028
PM 28541864
DA 2026-07-24
ER

PT J
AU de Leon, JM
   Barnes, S
   Nagel, M
   Fudge, M
   Lucius, A
   Garcia, B
AF de Leon, Jean M.
   Barnes, Sunni
   Nagel, Melody
   Fudge, Michelle
   Lucius, Adora
   Garcia, Betty
TI Cost-effectiveness of Negative Pressure Wound Therapy for Postsurgical
   Patients in Long-term Acute Care
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
AB OBJECTIVES: To evaluate the cost-effectiveness of negative pressure wound therapy (NPWT) using reticulated open-cell foam (NPWT/ROCF) as delivered by a Vacuum-Assisted Closure* (KCI Licensing, Inc, San Antonio, Texas) in patients with complex wounds in a long-term acute care (LTAC) setting. These patients are routinely discharged to LTAC hospitals with the goal of accelerating wound healing and timely transfer to a lower acuity care setting and are usually affected with serious comorbidities and deep, complex wounds with exposed anatomical structures, which require extended care (stay > 25 days).
   DESIGN: A retrospective chart review was conducted to determine the average daily wound volume reduction, average daily wound area reduction, and average cost per cubic centimeter of wound volume reduction for patients treated with NPWT/ROCF as compared with topical advanced moist healing strategies (non-NPWT).
   SETTING: All patients received treatment in an LTAC hospital.
   PARTICIPANTS: Patients admitted from November 2001 to August 2004 were identified using a computerized hospital database. The inclusion criteria were postsurgical patients of at least 18 years of age, with a single acute wound.
   INTERVENTION: Patients were treated with either NPWT/ROCF or advanced moist wound-healing therapies (non-NPWTs).
   MEASUREMENTS: Data collected included age, sex, wound measurements, Bates-Jensen Wound Assessment Tool severity score, procedures performed, wound care products and devices used, wound-healing outcomes, and costs associated with treatment.
   RESULTS: Fifty-one patients met the inclusion criteria: 36 were identified as NPWT/ROCF and 15 as non-NPWT. The NPWT/ROCF patients showed a statistically significantly higher average daily rate of volume reduction as compared with the advanced moist wound-healing group (5.02 +/- 13.36 vs 0.40 +/- 0.88 cm(3)/day; P = .046). The cost per cubic centimeter reduction was $11.90/cm(3) in the NPWT/ROCF group versus $30.92/cm(3) in the moist wound-healing group.
   CONCLUSION: Postsurgical LTAC patients who were treated by NPWT/ROCF had a more accelerated rate of wound closure, compared with patients treated with advanced moist wound-healing therapy. These results suggest that, for this patient group, NPWT/ROCF may be more clinically effective in reducing wound volume, compared with advanced moist wound healing. Furthermore, the lower cost per cubic centimeter volume reduction suggests that NPWT/ROCF produces a more favorable cost-effective solution. Therefore, it is important when developing a wound-healing strategy that cost decisions be based on overall cost and not individual product cost when using advanced technology as part of the overall treatment plan. This study serves as a basis for further work in cost-benefit analysis when considering evidence-based outcomes in wound care. ADV SKIN WOUND CARE 2009; 22: 122 - 7
C1 [de Leon, Jean M.] Baylor Specialty Hosp Wound Care & Outpatient Wou, Dallas, TX 75246 USA.
   [Barnes, Sunni] Baylor Hlth Care Syst, Dallas, TX USA.
   [Nagel, Melody] Baylor Specialty Hosp Wound Care, Dallas, TX USA.
   [Fudge, Michelle; Lucius, Adora; Garcia, Betty] Baylor Specialty Hosp, Dallas, TX USA.
C3 Baylor Scott & White Health
RP de Leon, JM (通讯作者)，Baylor Specialty Hosp Wound Care & Outpatient Wou, Dallas, TX 75246 USA.
FU KCI Licensing, Inc.
FX Institutional review board approval was obtained through the Baylor
   Specialty Hospital to perform this study. This study is sponsored by a
   research grant from KCI Licensing, Inc. *All trademarks and service
   marks designated concerning Vacuum-Assisted Closure are proprietary of
   KCI Licensing, Inc, San Antonio, Texas, its affiliates, and licensors.
CR [Anonymous], CROSS QUAL CHASM NEW
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   de Leon JM, 2005, CLIN S ADV SKIN WOUN
   Greene AK, 2006, ANN PLAS SURG, V56, P418, DOI 10.1097/01.sap.0000202831.43294.02
   Gupta Subhas, 2004, Adv Skin Wound Care, V17 Suppl 2, P1, DOI 10.1097/00129334-200411002-00001
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NR 21
TC 30
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2009
VL 22
IS 3
BP 122
EP 127
DI 10.1097/01.ASW.0000305452.79434.d9
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA V19SE
UT WOS:000208091300005
PM 19247013
DA 2026-07-24
ER

PT J
AU Wang, F
   Liu, S
   Qiu, L
   Ma, B
   Wang, J
   Wang, YJ
   Peszel, A
   Chen, XL
AF Wang, Fei
   Liu, Sheng
   Qiu, Le
   Ma, Ben
   Wang, Jian
   Wang, Yong-Jie
   Peszel, April
   Chen, Xu-Lin
TI Superthin Abdominal Wall Glove-Like Flap Combined With Vacuum-Assisted
   Closure Therapy for Soft Tissue Reconstruction in Severely Burned Hands
   or With Infection
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE burns; hand; VAC; superthin abdominal wall flap; glove-like flap
ID PRESSURE WOUND THERAPY
AB Severe burn and infection to hands always involves the deep structures, such as tendons, joints, and bones. These wounds cannot be closed immediately and therefore creates a high risk for complication. We presented 9 cases with deep dermal burns to the dorsal of the hand (6 electrical burns and 3 thermal crush injuries) with wound infections in 2 cases. The vacuum-assisted closure system was used continuously until the flap reconstruction was performed. A random pattern and superthin abdominal wall skin flap-like glove was designed. The flap was transferred to the defected portion of the dorsum of the hand and resected from the abdominal wall about 3 weeks later. The flaps in 8 of the patients treated by this technique survived completely and partial necrosis of the distal flap occurred in 1 patient. The defect resolved after operative treatment and the function of the hands and fingers were successfully salvaged. All patients resulted in having a satisfactory aesthetic outcome with no or minor discomfort at the abdominal donor area. Integration of the vacuum-assisted closure system and the superthin abdominal wall glove-like flap reconstruction appeared to be successful and should be considered in patients with severely burned hands.
C1 [Wang, Fei; Liu, Sheng; Qiu, Le; Ma, Ben; Wang, Jian; Wang, Yong-Jie; Peszel, April; Chen, Xu-Lin] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University
RP Chen, XL (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Burns, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
EM okcxl@126.com
RI ; chen, xu lin/KPY-0747-2024
OI , fei/0000-0001-9449-8361; 
CR Barillo DJ, 2001, BURNS, V27, P613, DOI 10.1016/S0305-4179(01)00014-6
   Calzoni C, 2012, ANN ITAL CHIR, V83, P125
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   Herndon D.N., 2012, Total burn care, V4th
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NR 25
TC 8
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2015
VL 75
IS 6
BP 603
EP 606
DI 10.1097/SAP.0000000000000602
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC2TT
UT WOS:000369070300007
PM 26418768
DA 2026-07-24
ER

PT J
AU Narducci, F
   Samouelian, V
   Marchaudon, V
   Koenig, P
   Fournier, C
   Phalippou, J
   Leblanc, E
AF Narducci, Fabrice
   Samouelian, Vanessa
   Marchaudon, Valerie
   Koenig, Philippe
   Fournier, Charles
   Phalippou, Jerome
   Leblanc, Eric
TI Vacuum-assisted closure therapy in the management of patients undergoing
   vulvectomy
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Vulvar cancer; Vulvectomy; Lymphadenectomy; Healing; Vacuum assisted
   closure
ID CANCER; COMPLICATIONS; CARCINOMA; TRENDS
AB Objectives: To investigate whether systematic postoperative VAC therapy could improve vulvectomy healing.
   Study design: We reviewed medical data from 54 women who underwent in the period of March 2006 to December 2009 radical vulvectomy or wide local vulvectomy with defect volume >40 cm(3). Patients were divided into two groups according to immediate postoperative care. Patients treated with systematic vacuum-assisted closure (VAC) therapy immediately after surgery were included in the "VAC group" while patients receiving conventional care (CC) were included in the "CC group".
   Results: The characteristics of the VAC group (n = 30) and CC group (n = 24) were similar and there were no significant differences in operative data, histological results or oncologic follow-up. The median length of use of VAC was 11 days after surgery (6-38). The length of hospital stay for patients in the VAC group and CC group was 17.8 (+/- 8.7) and 18.4 days (+/- 9.9) (p = 0.8) respectively. The lengths of complete healing were 44.4 (+/- 18.4) vs. 60.2 (+/- 28.7) days (p = 0.0175) respectively.
   Conclusions: In our study we proved that using VAC dressing immediately after vulvectomy (at least 6 cm x 7 cm) for 11 days reduces the total length of cicatrization by approximately 16 days. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Narducci, Fabrice; Samouelian, Vanessa; Marchaudon, Valerie; Koenig, Philippe; Fournier, Charles; Phalippou, Jerome; Leblanc, Eric] Ctr Oscar Lambret, Ctr Canc, F-59020 Lille, France.
C3 UNICANCER; Centre Oscar Lambret
RP Narducci, F (通讯作者)，Ctr Oscar Lambret, Ctr Canc, 3 Rue Frederic Combemale,BP 307, F-59020 Lille, France.
EM f-narducci@o-lambret.fr
OI Phalippou, Jerome/0000-0002-5396-7894; narducci,
   fabrice/0000-0001-5809-3535; leblanc, eric/0000-0001-7299-0339;
   PHALIPPOU, Jérôme/0000-0003-3779-6869
CR Ansink A, 2000, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD002036, DOI 10.1002/14651858.CD002036]
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   Schimp VL, 2004, GYNECOL ONCOL, V92, P586, DOI 10.1016/j.ygyno.2003.10.055
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NR 10
TC 18
Z9 20
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD APR
PY 2012
VL 161
IS 2
BP 199
EP 201
DI 10.1016/j.ejogrb.2011.12.016
PG 3
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 925MN
UT WOS:000302765400016
PM 22252048
DA 2026-07-24
ER

PT J
AU Greene, AK
   Puder, M
   Roy, R
   Arsenault, D
   Kwei, S
   Moses, MA
   Orgill, DP
AF Greene, AK
   Puder, M
   Roy, R
   Arsenault, D
   Kwei, S
   Moses, MA
   Orgill, DP
TI Microdeformational wound therapy - Effects on angiogenesis and matrix
   metalloproteinases in chronic wounds of 3 debilitated patients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE microdeformational wound therapy; MDWT; vacuum assisted closure; VAC;
   angiogenesis; matrix metalloprotemases; subatmospheric pressure; wound
   healing
ID VACUUM-ASSISTED CLOSURE; ENDOGENOUS INHIBITORS; GROWTH-CONTROL;
   ANGIOSTATIN; ULCERS; MATRIX-METALLOPROTEINASE-9; EXPRESSION; HYPOXIA;
   MODEL; MICE
AB The vacuum-assisted closure (VAC) device causes microdeformations of the wound Surface in contact with the foam Because angiogenesis and matrix metalloproteinase (MMP) activity are altered in chronic wounds, we hypothesized that microdeformations stimulate capillary formation and affect MMP activity. A VAC device was used to deliver microdeformational Wound therapy (MDWT) to the chronic wounds of 3 debilitated patients. Debrided tissue was obtained from Wound areas with and without foam contact. Microvessel density and MMP activity were determined by immunohistochemistry and zymography, respectively. Microvessel density of MDWT-treated wounds was 4.5% (+/- 0.8) compared with areas not covered by foam [1.6% (+/- 0.1)] (P = 0.05) during the first week of treatment and 2.7% (+/- 0.3) compared With untreated tissue [1.3% (+/- 0.1)] (P = 0.03) during the second treatment week. Wounds subjected to MDWT had greater microvessel density compared with the same wound prior to treatment [1.5% (+/- 0.3)] (P = 0.02). MMP-9/NGAL (neutrophil gelatinase-associated lipocalin), MMP-9, latent MMP-2. and active MMP-2 were reduced by 15%-76% in MDWT-treated wounds. MDWT provides a favorable wound-healing environment by increasing angiogenesis and decreasing MMP activity in chronic wounds.
C1 Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Harvard Plast Surg Program, Boston, MA 02115 USA.
   Harvard Univ, Childrens Hosp Boston, Dept Surg, Vasc Biol Program, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Harvard Plast Surg Program, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU NCI NIH HHS [CA4558, CA83106] Funding Source: Medline; NIDDK NIH HHS
   [1K08DK069621, DK065298] Funding Source: Medline
CR Ailawadi M, 2002, SURGERY, V131, P219, DOI 10.1067/msy.2002.118709
   [Anonymous], GENE THERAPY
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 35
TC 189
Z9 221
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2006
VL 56
IS 4
BP 418
EP 422
DI 10.1097/01.sap.0000202831.43294.02
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 026XP
UT WOS:000236376900018
PM 16557076
DA 2026-07-24
ER

PT J
AU Ahmed, AA
   Alasso, AAO
   Ibrahim, IG
   Omar, NMS
AF Ahmed, Abdullahi Ahmed
   Alasso, Abdirahman Ahmed Omar
   Ibrahim, Ismail Gedi
   Omar, Nasteho Mohamed Sheikh
TI Application of endoscopic vacuum-assisted closure therapy for
   oesophageal perforation: first case report in East Africa
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Oesophageal perforation; Endoscopic vacuum-assisted closure; Case
   report; East africa
ID LEAKS
AB Introduction and importance Oesophageal perforation is a critical condition associated with high morbidity and mortality, requiring rapid diagnosis and effective treatment. Endoscopic vacuum-assisted closure (EVAC) therapy has emerged as an innovative and effective approach for managing oesophageal perforations, offering advantages such as enhanced healing shorter hospital stay and reduced complications. Case presentation We report a case of oesophageal perforation complicated by subcutaneous emphysema, pleural effusions, and mild pneumothorax in a 40-year-old woman who presented with facial, neck, and chest swelling, dyspnoea, dysphagia, and fever following intubation during laparoscopic gynaecological surgery. Imaging revealed a defect in the oesophageal wall at the C5-C6 level with significant contrast extravasation and air tracking. Emergency surgical interventions, including chest tube placement, were performed, followed by a multidisciplinary treatment plan incorporating EVAC therapy. Post-treatment imaging demonstrated complete resolution of the perforation and associated complications. Clinical discussion This case highlights the utility of EVAC therapy as a safe and effective modality in the comprehensive management of oesophageal perforation, underscoring its role in improving patient outcomes. Conclusion EVAC therapy represents a promising approach for managing oesophageal perforations. It offers a minimally invasive alternative to traditional surgical treatment in resource-limited settings.This modality can potentially enhance healing, reduce complications, and lower costs.
C1 [Ahmed, Abdullahi Ahmed; Omar, Nasteho Mohamed Sheikh] Mogadishu Somali Turkey Training & Res Hosp, Dept Emergency Med, Mogadishu, Somalia.
   [Alasso, Abdirahman Ahmed Omar] Mogadishu Somali Turkey Training & Res Hosp, Dept Gen Surgary, Mogadishu, Somalia.
   [Ibrahim, Ismail Gedi] Mogadishu Somali Turkey Training & Res Hosp, Dept Radiol, Mogadishu, Somalia.
   [Ahmed, Abdullahi Ahmed] Basaksehir Cam & Sakura City Hosp, Istanbul, Turkiye.
RP Ahmed, AA (通讯作者)，Mogadishu Somali Turkey Training & Res Hosp, Dept Emergency Med, Mogadishu, Somalia.; Ahmed, AA (通讯作者)，Basaksehir Cam & Sakura City Hosp, Istanbul, Turkiye.
EM drfuqsade@gmail.com
OI Alasso, -Abdi/0000-0002-0778-4720
CR American Society for Gastrointestinal Endoscopy Technology Committee, 2024, IGIE, V3, P333, DOI [10.1016/j.igie.2024.06.003, 10.1016/j.igie.2024.06.003]
   Biancari F, 2013, WORLD J SURG, V37, P1051, DOI 10.1007/s00268-013-1951-7
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NR 13
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD FEB 1
PY 2026
VL 21
IS 1
AR 104
DI 10.1186/s13019-026-03857-9
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA EJ6MV
UT WOS:001702660000001
PM 41622226
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cuccia, G
   Mucciardi, G
   Morgia, G
   d'Alcontres, FS
   Galì, A
   Cotrufo, S
   Romeo, M
   Magno, C
AF Cuccia, Giuseppe
   Mucciardi, Giuseppe
   Morgia, Giuseppe
   d'Alcontres, Francesco Stagno
   Gali, Alessandro
   Cotrufo, Stefano
   Romeo, Marco
   Magno, Carlo
TI Vacuum-Assisted Closure for the Treatment of Fournier's Gangrene
SO UROLOGIA INTERNATIONALIS
LA English
DT Article
DE Assessment; Fournier's gangrene; Vacuum-assisted closure; Surgical
   treatment
ID HYPERBARIC-OXYGEN; EXPERIENCE
AB Background: Fournier's gangrene (FG) is a very aggressive necrotizing fasciitis involving subcutaneous fat and skin of scrotal and perineal regions. Vacuum-assisted closure (VAC) is a well-known method used to treat complex wounds. The authors for the first time enhance a multimodal strategy to treat the FG using VAC, reducing the number of surgical debridements, allowing a one-step surgical reconstruction with locoregional fasciocutaneous flap. Methods: Six patients with the diagnosis of FG were reviewed retrospectively at our institution. All patients were affected by very extensive FG. The FG Severity Index (FGSI) was used to evaluate the prognosis of the case at admission. Following the acute phase (24-48 h), VAC was used to achieve wound cleaning and prepare the area to a single-stage reconstruction with superomedial thigh flap. Hyperbaric oxygen therapy was also used before final reconstruction. Results: The average FGSI was 10.5, ranging from 8 to 12. All patients survived and were completely healed at the mean follow-up time of 9 months (range 3-30 months). Conclusions: VAC therapy is effective to clean and prepare the wounds, cutting off the fasciitis process and reducing the hospital stay and patient discomfort. Multidisciplinary treatment is mandatory during this devastating infection. Copyright (C) 2009 S. Karger AG, Basel
C1 [Mucciardi, Giuseppe; Morgia, Giuseppe; Gali, Alessandro; Magno, Carlo] Univ Messina, Dept Urol, Messina, Italy.
   [Cuccia, Giuseppe; d'Alcontres, Francesco Stagno; Cotrufo, Stefano; Romeo, Marco] Univ Messina, Plast Surg Unit, Messina, Italy.
C3 University of Messina; University of Messina
RP Magno, C (通讯作者)，Messina Univ Policlin, Dept Urol, Via Consolare Valeria, IT-98100 Messina, Italy.
EM cmagno@unime.it
OI Morgia, Giuseppe/0000-0002-7224-7577
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NR 23
TC 41
Z9 50
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PY 2009
VL 82
IS 4
BP 426
EP 431
DI 10.1159/000218532
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 456WQ
UT WOS:000266883200010
PM 19506410
DA 2026-07-24
ER

PT J
AU Stevens, P
AF Stevens, Philip
TI Vacuum-assisted closure of laparostomy wounds: a critical review of the
   literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Laparostomy; Open abdomen; Temporary abdominal closure; Topical negative
   pressure; Vacuum-assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; TOPICAL NEGATIVE-PRESSURE; OPEN ABDOMEN;
   FASCIAL CLOSURE; VENTRAL HERNIA; TRAUMA; EXPERIENCE; THERAPY
AB Vacuum-assisted closure (VAC) reduces the burden for carers of laparostomy wounds but evidence from randomised trials is lacking. This review analyses the evidence for the VAC (R) abdominal wound management system (KCI, San Antonio, TX) in the open abdomen. Three prospective studies provide level III evidence that VAC (R) allows delayed primary fascial closure in the majority of these wounds up to 21 days after occurrence, but not where duration of VAC (R) was less than 9 days or if vacuum pack techniques were used in place of VAC (R). Fistulae occurred in a minority of wounds complicated by multi-organ failure or sepsis and could not be attributed to VAC (R) itself. Two retrospective analyses suggested VAC (R) may reduce re-operation rate and length of stay in complex wounds. Whilst randomised controlled trials remain the gold standard of evidence for effectiveness of health care interventions, contemporaneous level III evidence supports the hypothesis that VAC (R) increases the rate of primary fascial closure. Whilst enterocutaneous fistula formation is reported in the most complex of these wounds, there is no more evidence that these are consequential to as opposed to coincident with VAC (R) use.
C1 Nevill Hall Hosp, Dept Gen Surg, Abergavenny NP7 7EG, Gwent, Wales.
RP Stevens, P (通讯作者)，Nevill Hall Hosp, Dept Gen Surg, Brecon Rd, Abergavenny NP7 7EG, Gwent, Wales.
EM Stevens_P1@hotmail.com
CR [Anonymous], CORE TOPICS GEN EMER
   [Anonymous], CRITICAL CARE POSTGR
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NR 51
TC 56
Z9 61
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2009
VL 6
IS 4
BP 259
EP 266
DI 10.1111/j.1742-481X.2009.00614.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BW
UT WOS:000207846100002
PM 19719522
OA Green Submitted
DA 2026-07-24
ER

PT J
AU DeFranzo, AJ
   Argenta, LC
   Marks, MW
   Molnar, JA
   David, LR
   Webb, LX
   Ward, WG
   Teasdall, RG
AF DeFranzo, AJ
   Argenta, LC
   Marks, MW
   Molnar, JA
   David, LR
   Webb, LX
   Ward, WG
   Teasdall, RG
TI The use of vacuum-assisted closure therapy for the treatment of
   lower-extremity wounds with exposed bone
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 68th Annual Meeting of the
   American-Society-of-Plastic-and-Reconstructive-Surgeons
CY OCT 23-27, 1999
CL NEW ORLEANS, LA
SP Amer Soc Plast & Reconstruct Surgeons
ID SKIN
AB Lower-extremity wounds with exposed tendon, bone, or orthopedic hardware present a difficult treatment challenge. In this series of patients, subatmospheric pressure therapy was applied to such lower-extremity wounds. Seventy-five patients with lower-extremity Wounds, most of which were the result of trauma, were selected for this study. Dressings made of sterile open-cell foam with embedded fenestrated tithing were contoured to the Wound size and placed into the wound. The site was covered with an adhesive plastic sheet. The Sheet was placed beneath any external fixation devices, or the fixation device was enclosed within the sheet. The tubing was connected to the vacuum-assisted closure pump. Continuous subatmospheric suction pressure (125 mmHg) was applied to the wound site. The wounds were inspected and the dressings were changed every, 48 hours.
   Vacuum-assisted closure therapy greatly reduced the amount of tissue edema, diminishing the circumference of the extremity and thus decreasing the surface area of the wound. Profuse granulation tissue formed rapidly, covering bone and hardware. The wounds were closed primarily and covered with split-thickness skin grafts, or a regional flap was rotated into the granulating bed to fill the defect. Successful coverage was obtained without complication in 71 of 75 patients. Wounds have been stable from 6 months up to 6 years.
C1 Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Orthoped Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University
RP DeFranzo, AJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
RI /AAM-1164-2020; Molnar, Joseph/AEK-5540-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   CHERRY GW, 1983, PLAST RECONSTR SURG, V72, P680, DOI 10.1097/00006534-198311000-00018
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   OLENIUS M, 1993, PLAST RECONSTR SURG, V91, P213, DOI 10.1097/00006534-199302000-00001
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NR 7
TC 328
Z9 393
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2001
VL 108
IS 5
BP 1184
EP 1191
DI 10.1097/00006534-200110000-00013
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 479XJ
UT WOS:000171428900013
PM 11604617
DA 2026-07-24
ER

PT J
AU Rapp, SJ
   Dershem, V
   Zhang, X
   Schutte, SC
   Chariker, ME
AF Rapp, Scott J.
   Dershem, Victoria
   Zhang, Xiang
   Schutte, Stacey C.
   Chariker, Mark E.
TI Varying Negative Pressure Wound Therapy Acute Effects on Human
   Split-Thickness Autografts
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; GLUE
AB Over 6.5 million people in the United States suffer from traumatic, burn, acute, and chronic wounds yearly. When reconstruction is required, split and full-thickness autografts are a first line of treatment intervention. Negative pressure wound therapy (NPWT) is gaining traction as an adjunct modality to improve graft survival, yet the specifics on what settings to apply topically over the graft is unsubstantiated and associated with morbidities. This study was performed in an effort to understand initial changes in wound and graft healing with a long-term goal of surface pressure optimization. Excess skin from elective procedures from six human subjects was trimmed to 0.012 inch in order represent a split-thickness autografts. These grafts were treated continuously with either -75 mm Hg (n = 4), -125 mm Hg (n = 4), or no pressure (n = 4) for 3 hours. Six skin grafts were treated with no sponge or pressure control (n = 6). RNAseq was performed on all treatment groups and compared with no pressure control. Significant gene expression changes with a subset focusing on inflammatory, cellular/extracellular matrix proliferation and angiogenic mediators and having greater than 2-fold were confirmed with immunohistochemistry staining. There are 95 significant gene transcription differences among all treatment groups. NPWT leads to significantly increased gene expression of FGFR1, ET-1, and 22 Keratin proteins. Between -75 and -125 mm Hg groups, there are 19 significant gene changes. Proinflammatory genes S100A8 and Tenacin C (TNC) demonstrate an 8.8- and 9.1-fold change, respectively, and is upregulated in -125 mm Hg group and downregulated in -75 mm Hg group. Fibrinogen genes fibrinogen gamma chain and fibrinogen alpha chain had respective log2-fold changes of -7.9 and -7.4 change between treatment groups and were downregulated in -125 mm Hg group and upregulated in -75 mm Hg group. There are varying effects of surface pressures on human split-thickness autografts during the imbibition time period. NPWT may improve cellular migration, proliferation, and angiogenesis over controls. Human skin grafts respond differently to -125 and -75 mm Hg within 3 hours of NPWT treatment. The results suggest -75 mm Hg leads to less inflammation and increased fibrinogen production compared with the -125 mm Hg group, at least initially. Reducing "time to heal" with NPWT is critical to successful outcomes and quality of life within young patients who often experience pain/discomfort when treated at the current standard pump settings. The results from this study and continued investigation may quickly translate to the clinical setting by finding the ideal pressure setting utilized in an effort to reduce NPWT length of treatment, improve patient comfort, satisfaction, and psychosocial well-being.
C1 [Rapp, Scott J.; Dershem, Victoria; Schutte, Stacey C.] Shriners Hosp Children, Dept Res, Div Pediat Plast Surg, Cincinnati, OH 45229 USA.
   [Rapp, Scott J.; Chariker, Mark E.] Norton Childrens Hosp, Dept Surg, Div Plast Surg, Louisville, KY USA.
   [Zhang, Xiang; Schutte, Stacey C.] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA.
   [Rapp, Scott J.; Chariker, Mark E.] Kentucky Ctr Cosmet & Reconstruct Surg, Louisville, KY USA.
C3 University System of Ohio; University of Cincinnati
RP Rapp, SJ (通讯作者)，Shriners Hosp Children, Div Plast Surg, 3229 Burnet Ave, Cincinnati, OH 45229 USA.
EM srapp@shinenet.org
RI Schutte, Stacey/L-9039-2019
OI Schutte, Stacey/0000-0002-8092-5067
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   Veniaminova NA, 2013, DEVELOPMENT, V140, P4870, DOI 10.1242/dev.101725
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NR 30
TC 21
Z9 27
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2020
VL 41
IS 1
BP 104
EP 112
DI 10.1093/jbcr/irz122
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA LD2DZ
UT WOS:000525842600013
PM 31420676
DA 2026-07-24
ER

PT J
AU Diaz, JJ
   Dutton, WD
   Ott, MM
   Cullinane, DC
   Alouidor, R
   Armen, SB
   Bilanuik, JW
   Collier, BR
   Gunter, OL
   Jawa, R
   Jerome, R
   Kerwin, AJ
   Kirby, JP
   Lambert, AL
   Riordan, WP
   Wohltmann, CD
AF Diaz, Jose J., Jr.
   Dutton, William D.
   Ott, Mickey M.
   Cullinane, Daniel C.
   Alouidor, Reginald
   Armen, Scott B.
   Bilanuik, Jaroslaw W.
   Collier, Bryan R.
   Gunter, Oliver L.
   Jawa, Randeep
   Jerome, Rebecca
   Kerwin, Andrew J.
   Kirby, John P.
   Lambert, Anne L.
   Riordan, William P.
   Wohltmann, Christopher D.
TI Eastern Association for the Surgery of Trauma: A Review of the
   Management of the Open Abdomen-Part 2 "Management of the Open Abdomen"
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
ID ACELLULAR DERMAL MATRIX; ABDOMINAL-WALL RECONSTRUCTION; VACUUM-ASSISTED
   CLOSURE; DAMAGE CONTROL LAPAROTOMY; PLANNED VENTRAL HERNIA; EARLY
   FASCIAL CLOSURE; WOUND CLOSURE; ENTEROCUTANEOUS FISTULA; COMPARTMENT
   SYNDROME; STAGED MANAGEMENT
C1 [Diaz, Jose J., Jr.; Dutton, William D.; Ott, Mickey M.; Collier, Bryan R.; Gunter, Oliver L.; Riordan, William P.] Vanderbilt Univ, Med Ctr, Dept Surg, Div Trauma & Surg Crit Care, Nashville, TN 37212 USA.
   [Jawa, Randeep] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN 37212 USA.
   [Cullinane, Daniel C.] Mayo Clin, Dept Surg, Div Trauma Crit Care & Gen Surg, Rochester, MN USA.
   [Alouidor, Reginald] Bay State Med Ctr, Dept Surg, Div Trauma, Springfield, MA USA.
   [Armen, Scott B.] Penn State Hershey Med Ctr, Div Trauma Acute Care & Crit Care Surg, Hershey, PA USA.
   [Bilanuik, Jaroslaw W.] Morristown Mem Hosp, Dept Surg, Morristown, NJ USA.
   [Jawa, Randeep] Univ Nebraska Med Ctr, Dept Surg, Omaha, NE USA.
   [Kerwin, Andrew J.] Univ Florida HSC, Div Acute Care Surg, Dept Surg, Jacksonville, FL USA.
   [Kirby, John P.] Washington Univ, Med Ctr, Div Gen Surg, Sect Acute & Crit Care Surg, St Louis, MO USA.
   [Lambert, Anne L.] Hennepin Cty Med Ctr, Dept Surg General Trauma & Plast Burn & Reconstru, St Paul, MN USA.
   [Wohltmann, Christopher D.] So Illinois Univ, Sch Med, Dept Surg, Div Gen Surg, Springfield, IL 62794 USA.
C3 Vanderbilt University; Vanderbilt University; Mayo Clinic; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; Atlantic Health System; University of
   Nebraska System; University of Nebraska Medical Center; State University
   System of Florida; University of Florida; Washington University (WUSTL);
   Hennepin County Medical Center; Southern Illinois University System;
   Southern Illinois University
RP Diaz, JJ (通讯作者)，Vanderbilt Univ, Med Ctr, Dept Surg, Div Trauma & Surg Crit Care, 1211 21st Ave S,404 Med Arts Bldg, Nashville, TN 37212 USA.
EM jose.diaz@vanderbilt.edu
RI ; Diaz, Jose/JXN-9172-2024
OI Cullinane, Daniel/0000-0002-0414-1949; Diaz, Jose/0000-0001-8177-9471;
   Kerwin, Anew/0000-0003-4372-5813
CR [Anonymous], 2000, ACTA CHIRURG AUSTRIA
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NR 75
TC 57
Z9 68
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
IS 2
BP 502
EP 512
DI 10.1097/TA.0b013e318227220c
PG 11
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806XH
UT WOS:000293850200060
PM 21825951
DA 2026-07-24
ER

PT J
AU Sahebally, SM
   McKevitt, K
   Stephens, I
   Fitzpatrick, F
   Deasy, J
   Burke, JP
   McNamara, D
AF Sahebally, Shaheel Mohammad
   McKevitt, Kevin
   Stephens, Ian
   Fitzpatrick, Fidelma
   Deasy, Joseph
   Burke, John Patrick
   McNamara, Deborah
TI Negative Pressure Wound Therapy for Closed Laparotomy Incisions in
   General and Colorectal Surgery A Systematic Review and Meta-analysis
SO JAMA SURGERY
LA English
DT Review
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   MANAGEMENT-SYSTEM; CLINICAL-TRIALS; PREVENTION; HERNIA; IMPACT; WALL
AB IMPORTANCE Surgical site infections (SSls) are common after laparotomy wounds and are associated with a significant economic burden. The use of negative pressure wound therapy (NPWT) has recently been broadened to closed surgical incisions.
   OBJECTIVE To evaluate the association of prophylactic NPWT with SSI rates in closed laparotomy incisions performed for general and colorectal surgery in elective and emergency settings.
   DATA SOURCES The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases were searched without language restrictions for relevant articles from inception until December 2017. The latest search was performed on December 31, 2017. The bibliographies of retrieved studies were further screened for potential additional studies.
   STUDY SELECTION Randomized clinical trials and nonrandomized studies were included. Unpublished reports were excluded, as were studies that examined NPWT (or standard nonpressure) dressings only without a comparator group. Studies that evaluated the use of NPWT in open abdominal incisions were also excluded. Disagreement was resolved by discussion, and if the question remained unsettled, the opinion of the senior author was sought. A total of 198 citations were identified, and 189 were excluded.
   DATA EXTRACTION AND SYNTHESIS This meta-analysis was conducted according to PRISMA guidelines. Data were independently extracted by 2 authors. A random-effects model was used for statistical analysis.
   MAIN OUTCOMES AND MEASURES The primary outcome measure was SSI, and secondary outcomes included seroma and wound dehiscence rates. These outcomes were chosen before data collection.
   RESULTS Nine unique studies (3 randomized trials and 2 prospective and 4 retrospective studies) capturing 1266 unique patients were included. Of these, 1187 patients with 1189 incisions were included in the final analysis (52.3% male among 7 studies reporting data on sex; mean [SD] age, 52 [15] years among 8 studies reporting data on age). Significant clinical and methodologic heterogeneity existed among studies. On random-effects analysis, NPWT was associated with a significantly lower rate of 551 compared with standard dressings (pooled odds ratio [OR], 0.25; 95% Cl, 0.12-0.52; P <.001). However, no difference in rates of seroma (pooled OR, 0.38; 95% Cl, 0.12-1.23; P = .11) or wound dehiscence (pooled OR, 2.03; 95% Cl, 0.61-6.78; P =.25) was found. On sensitivity analysis, focusing solely on colorectal procedures, NPWT significantly reduced 551 rates (pooled OR, 0.16; 95% Cl, 0.07-0.36; P <.001).
   CONCLUSIONS AND RELEVANCE Application of NPVVT on closed laparotomy wounds in general and colorectal surgery is associated with reduced 551 rates but similar rates of seroma and wound dehiscence compared with conventional nonpressure dressings.
C1 [Sahebally, Shaheel Mohammad; McKevitt, Kevin; Stephens, Ian; Deasy, Joseph; Burke, John Patrick; McNamara, Deborah] Beaumont Hosp, Dept Colorectal Surg, Beaumont Rd, Dublin 9, Ireland.
   [Fitzpatrick, Fidelma] Beaumont Hosp, Dept Clin Microbiol, Dublin, Ireland.
   [Fitzpatrick, Fidelma; Burke, John Patrick; McNamara, Deborah] Royal Coll Surgeons Ireland, Dublin, Ireland.
C3 Beaumont Hospital Dublin; Beaumont Hospital Dublin; Royal College of
   Surgeons in Ireland - RCSI
RP Sahebally, SM (通讯作者)，Beaumont Hosp, Dept Colorectal Surg, Beaumont Rd, Dublin 9, Ireland.
EM sahebalm@tcd.ie
RI ; Stephens, Ian/LCE-0459-2024; McNamara, Deborah/AGI-5820-2022;
   fitzpatrick, fidelma/P-5483-2018
OI Deasy, Joseph/0000-0002-9437-266X; Stephens, Ian/0000-0001-5097-4602;
   McNamara, Deborah/0000-0003-3975-0485; fitzpatrick,
   fidelma/0000-0002-3204-5962
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NR 53
TC 132
Z9 141
U1 1
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD NOV
PY 2018
VL 153
IS 11
AR e183467
DI 10.1001/jamasurg.2018.3467
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HB0PM
UT WOS:000450718300003
PM 30267040
OA Bronze
DA 2026-07-24
ER

PT J
AU Peinemann, F
   McGauran, N
   Sauerland, S
   Lange, S
AF Peinemann, Frank
   McGauran, Natalie
   Sauerland, Stefan
   Lange, Stefan
TI Negative pressure wound therapy: Potential publication bias caused by
   lack of access to unpublished study results data
SO BMC MEDICAL RESEARCH METHODOLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SYSTEMATIC REVIEWS; PHARMACEUTICAL-INDUSTRY;
   RANDOMIZED-TRIAL; LEG ULCERS; METAANALYSES; SPONSORSHIP; MANAGEMENT;
   EFFICACY; IMPACT
AB Background: Negative pressure wound therapy (NPWT) is widely applied, although the evidence base is weak. Previous reviews on medical interventions have shown that conclusions based on published data alone may no longer hold after consideration of unpublished data. The main objective of this study was to identify unpublished randomised controlled trials (RCTs) on NPWT within the framework of a systematic review.
   Methods: RCTs comparing NPWT with conventional wound therapy were identified using MEDLINE, EMBASE, CINAHL and The Cochrane Library. Every database was searched from inception to May 2005. The search was updated in December 2006. Reference lists of original articles and systematic reviews, as well as congress proceedings and online trial registers, were screened for clues to unpublished RCTs. Manufacturers of NPWT devices and authors of conference abstracts were contacted and asked to provide study information. Trials were considered nonrandomised if concealment of allocation to treatment groups was classified as "inadequate". The study status was classified as "completed", "discontinued", "ongoing" or "unclear". The publication status of completed or discontinued RCTs was classified as "published" if a full-text paper on final study results ( completed trials) or interim results (discontinued trials) was available, and "unpublished" if this was not the case. The type of sponsorship was also noted for all trials.
   Results: A total of 28 RCTs referring to at least 2755 planned or analysed patients met the inclusion criteria: 13 RCTs had been completed, 6 had been discontinued, 6 were ongoing, and the status of 3 RCTs was unclear. Full-text papers were available on 30% of patients in the 19 completed or discontinued RCTs ( 495 analysed patients in 10 published RCTs vs. 1154 planned patients in 9 unpublished RCTs). Most information about conference abstracts and unpublished study information referring to trials that were unpublished at the time these documents were generated was obtained from the manufacturer Kinetic Concepts Inc. ( KCI) ( 19 RCTs), followed by The Cochrane Library ( 18) and a systematic review ( 15). We were able to obtain some information on the methods of unpublished RCTs, but results data were either not available or requests for results data were not answered; the results of unpublished RCTs could therefore not be considered in the review. One manufacturer, KCI, sponsored the majority of RCTs (19/28; 68%). The sponsorship of the remaining trials was unclear.
   Conclusion: Multi-source comprehensive searches identify unpublished RCTs. However, lack of access to unpublished study results data raises doubts about the completeness of the evidence base on NPWT.
C1 [Peinemann, Frank; McGauran, Natalie; Lange, Stefan] Inst Qual & Efficiency Hlth Care IQWiG, D-51105 Cologne, Germany.
   [Sauerland, Stefan] Univ Witten Herdecke, Inst Res Operat Med, D-51109 Cologne, Germany.
C3 Witten Herdecke University
RP Peinemann, F (通讯作者)，Inst Qual & Efficiency Hlth Care IQWiG, Dillenburger Str 27, D-51105 Cologne, Germany.
EM frank.peinemann@iqwig.de; n.mcgauran@iqwig.de;
   stefan.sauerland@infomuni-wh.de; stefan.lange@iqwig.de
RI ; Peinemann, Frank/H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X; Peinemann,
   Frank/0000-0002-4727-1313
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   2007, METHODS VERSION 2 0
   2007, NEGATIVE PRESSURE WO
NR 82
TC 35
Z9 39
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2288
J9 BMC MED RES METHODOL
JI BMC Med. Res. Methodol.
PD FEB 11
PY 2008
VL 8
AR 4
DI 10.1186/1471-2288-8-4
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 288GJ
UT WOS:000254973900001
PM 18267008
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, C
   Zhang, JX
   Liu, ZZ
AF Wang, Chao
   Zhang, Jixun
   Liu, Zhenzhong
TI Vacuum-assisted closure therapy combined with bi-pectoral muscle flap
   for the treatment of deep sternal wound infections
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bi-pectoral muscle flap; deep sternal wound infections; vacuum-assisted
   closure therapy
ID SURGICAL SITE INFECTION; POSTSTERNOTOMY MEDIASTINITIS; CLOSED DRAINAGE;
   SURGERY; MANAGEMENT
AB Deep sternal wound infection (DSWI) is a fatal complication after median sternotomy. This study was to assess the effect of vacuum-assisted closure (VAC) combined with bi-pectoral muscle advancement flap therapy on rehabilitation for the treatment of DSWI. Fifty-two patients with DSWI underwent treatment of VAC and bi-pectoral muscle flap. These patients were followed-up 12 months postoperation. The patient characteristics, duration of VAC therapy, the mean hospital stay, and postoperative complications were retrospectively analysed. All patients underwent 1 to 3 VAC treatment sessions before closure. Fifty-one of 52 DSWI patients were cured to discharge; the mean hospital stay was 26.5 days. The drainage tube continued to drain a large amount of bloody fluid in three patients after the wound was closed. Respiratory failure occurred in one patient with severe mediastinal and pulmonary infections and died eventually in hospital. One patient died of acute cerebral haemorrhage during the12-month follow-up. VAC therapy combined with bi-pectoral muscle flap is a simple and effective treatment for DSWIs with short hospital stays and few complications. However, this is a retrospective case series presentation with no comparison group; further large-scale controlled studies are needed.
C1 [Wang, Chao; Zhang, Jixun; Liu, Zhenzhong] Shandong Univ, Hosp 2, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
C3 Shandong University
RP Liu, ZZ (通讯作者)，Shandong Univ, Hosp 2, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
EM drliuzhenzhong@163.com
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NR 21
TC 9
Z9 13
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 332
EP 338
DI 10.1111/iwj.13277
EA DEC 2019
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000499634900001
PM 31788960
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Reiter, M
   Harréus, U
AF Reiter, Maximilian
   Harreus, Ulrich
TI Vacuum assisted closure in the management of wound healing disorders in
   the head and neck: A retrospective analysis of 23 cases
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID SKIN-GRAFTS; THERAPY; DEVICE
AB Background: Since the middle of the 1990s vacuum-assisted closure (VAC) has been used in many areas of surgery to manage complex wounds and impaired wound healing. Until recently, little attention has been paid to this treatment modality in the field of head and neck surgery. The evaluation of its efficacy in wound healing disorders of the head and neck was the aim of this study.
   Material and methods: Patients with complex wounds and impaired healing treated with VAC therapy between 2008 and 2011 were included into the study. VAC dressings were changed every 3 days and improvements in wound healing were documented.
   Results: 23 patients were treated with VAC therapy, in 18 cases (78%) closure of the defect could be reached without any further surgical procedure. 5 patients needed subsequent regional flap reconstruction to close the remaining defect. All of these patients had undergone salvage surgery in a previously irradiated neck before.
   Conclusion: Vacuum assisted closure is an effective treatment in the management of wound healing disorders and complex wounds in the head and neck. It offers a useful, non-invasive modality to close even large defects in the area. Previous irradiation seems to have a significant negative influence on the outcome of the therapy, but more data are required to assess these effects. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Reiter, Maximilian; Harreus, Ulrich] Univ Munich, Dept Otolaryngol Head & Neck Surg, D-81377 Munich, Germany.
C3 University of Munich
RP Reiter, M (通讯作者)，Univ Munich, Dept Otorhinolaryngol Head & Neck Surg, Grosshadem Clin, Marchioninistr 15, D-81377 Munich, Germany.
EM maximilian.reiter@med.uni-muenchen.de
OI Reiter, Maximilian/0000-0003-3100-6838
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NR 27
TC 20
Z9 25
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD SEP-OCT
PY 2013
VL 34
IS 5
BP 411
EP 415
DI 10.1016/j.amjoto.2013.03.001
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 214QC
UT WOS:000324149400009
PM 23558358
DA 2026-07-24
ER

PT J
AU Boettcher-Haberzeth, S
   Schiestl, C
AF Boettcher-Haberzeth, Sophie
   Schiestl, Clemens
TI Management of Avulsion Injuries
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE avulsion injury; children; Vacuum Assisted Closure system; Integra
   Dermal Regeneration Template
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; DEGLOVING
   INJURIES; LOWER-LIMB; SKIN; CONTRACTION; EXTREMITIES; CHILDREN; FLAP
AB The optimal management sequence to treat avulsion injuries in children is particularly difficult because of the following problems: (1) Assessment of these rare but frequently massive injuries can be very difficult and treacherous, as the extent of the injury is often underestimated and treatment therefore considered inappropriate; (2) Avulsion injuries have a high risk of infection: lesions are always contaminated due to the mechanism of injury (mostly vehicle accidents) and subsequent long-term hospitalization adds an additional risk for nosocomial infections; (3) Children with avulsion injuries have an increased risk to develop functional deficits: although the body grows, scars and reconstructed tissues may not adapt sufficiently and this may lead to serious constraints. Because of these problems, avulsion injuries may lead to a high morbidity and even mortality, especially if the injury is mismanaged. Reviewing the most recent data regarding the management of avulsion injuries yields the following key points: (1) A scoring system may help to assess the primary dimension of the defect; (2) Innovative techniques such as the use of a Vacuum Assisted Closure system may lower the risk of infection; (3) Choosing a comprehensive, reconstructive approach taking the growth of the child into consideration, may reduce the development of serious functional deficits and improve cosmetic outcome.
C1 [Boettcher-Haberzeth, Sophie; Schiestl, Clemens] Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Reconstruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
   [Boettcher-Haberzeth, Sophie] Univ Childrens Hosp Zurich, Tissue Biol Res Unit, Dept Surg, CH-8032 Zurich, Switzerland.
C3 University Children's Hospital Zurich; University Children's Hospital
   Zurich
RP Schiestl, C (通讯作者)，Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Reconstruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
EM clemens.schiestl@kispi.uzh.ch
RI Böttcher, Sophie/JBS-3818-2023
OI Böttcher, Sophie/0000-0002-7713-9807
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NR 21
TC 7
Z9 13
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2013
VL 23
IS 5
BP 359
EP 364
DI 10.1055/s-0033-1353493
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 220YO
UT WOS:000324623700004
PM 23982820
DA 2026-07-24
ER

PT J
AU Chen, E
   Friedman, HI
AF Chen, Elliott
   Friedman, Harold I.
TI Management of Regional Hidradenitis Suppurativa With Vacuum-Assisted
   Closure and Split Thickness Skin Grafts
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE hidradenitis suppurativa; vacuum-assisted closure; split thickness skin
   grafts
ID NEGATIVE-PRESSURE DRESSINGS; PATHOGENESIS; APOCRINE; THERAPY;
   CLINDAMYCIN; EFFICACY; EXCISION; TRIAL
AB Background: Hidradenitis suppurativa can be a debilitating chronic illness. The underlying cause of the disease is still not clear, but effective treatment of widespread regional disease relies on resection of all the involved skin and subcutaneous tissue. Closure of the resulting large wound is dependent on either flap or skin graft coverage. Many of the resulting wounds are too large for flap closure or result in unacceptable flap donor site deficits.
   Methods: We present a series of 11 patients with 24 regional disease sites treated with a protocol of excision, followed by wound vacuum-assisted closure (VAC; KCI, San Antonio, TX) therapy to stimulate angiogenesis of exposed fat, and then skin grafting with the use of VAC to support the grafts on the recipient sites.
   Results: Only 3 of the patients required regrafting. One patient had a VAC failure because of poor patient compliance, and 1 patient had 4 sites that each required regrafting as the epithelium would not fill in the residual open areas as it usually did in other patients. All patients were cured of their local disease.
   Conclusions: Massive regional hidradenitis suppurativa can be successfully managed with wide excision, VAC therapy, and skin grafting to allow these patients to live normal and productive lives.
C1 [Chen, Elliott; Friedman, Harold I.] Univ S Carolina, Div Plast Surg, Dept Surg, Sch Med, Columbia, SC 29203 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Friedman, HI (通讯作者)，Univ S Carolina, Div Plast Surg, Dept Surg, Sch Med, Suite 302,2 Med Pk Rd, Columbia, SC 29203 USA.
EM harold.friedman@uscmed.sc.edu
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NR 41
TC 54
Z9 57
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2011
VL 67
IS 4
BP 397
EP 401
DI 10.1097/SAP.0b013e3181f77bd6
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 821BC
UT WOS:000294948800018
PM 21587057
DA 2026-07-24
ER

PT J
AU Oguz, A
   Gümüs, M
   Turkoglu, A
   Bozdag, Z
   Ülger, BV
   Agaçayak, E
   Böyük, A
AF Oguz, Abdullah
   Gumus, Metehan
   Turkoglu, Ahmet
   Bozdag, Zubeyir
   Ulger, Burak Veli
   Agacayak, Elif
   Boyuk, Abdullah
TI Fournier's Gangrene: A Summary of 10 Years of Clinical Experience
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Fournier's gangrene; Trephine ostomy; Vacuum-assisted closure; Mortality
ID VACUUM-ASSISTED CLOSURE; SEVERITY INDEX; MANAGEMENT; MORTALITY
AB We aimed to present our clinical experience with FG treatment. Fournier's gangrene (FG) is a rare but serious disease characterized by progressive necrosis in the genitourinary and perineal region. The retrospective study included 43 patients. Patients were divided into 2 groups as survivors and nonsurvivors. Included in the analysis were data pertaining to demographics, predisposing factors, comorbidities, results of bacteriologic analyses, number of debridements, duration of treatment, FG Severity Index (FGSI) score, fecal diversion methods (trephine ostomy or Flexi-Seal Fecal Management System-FMS), and dressing methods (wet or negative aspiration system). In the nonsurvivor group, urea, WBC, and age were significantly higher, whereas albumin, hematocrit, platelet count, and length of hospital stay (LOHS) were significantly lower compared to the survivor group. Mean FGSI was lower in survivors in comparison with nonsurvivors (5.00 +/- 1.86 and 10.00 +/- 1.27, respectively; P < 0.001). We conclude that FGSI is an important predictor in the prognosis of FG. Vacuum-assisted closure (VAC) should be performed in compliant patients in order to enhance patient comfort by reducing pain and the number of dressings. Fecal diversion should be performed as needed, preferably by using FMS. The trephine ostomy should be the method of choice in cases where an ostomy is necessary.
C1 [Oguz, Abdullah; Gumus, Metehan; Turkoglu, Ahmet; Bozdag, Zubeyir; Ulger, Burak Veli; Boyuk, Abdullah] Dicle Univ, Fac Med, Dept Gen Surg, TR-21280 Diyarbakir, Turkey.
   [Agacayak, Elif] Dicle Univ, Fac Med, Dept Obstet & Gynecol B, TR-21280 Diyarbakir, Turkey.
C3 Dicle University; Dicle University
RP Oguz, A (通讯作者)，Dicle Univ, Fac Med, Dept Gen Surg, TR-21280 Diyarbakir, Turkey.
EM dragtiz@hotmail.com
RI /Q-6602-2019
CR ANDERSON ID, 1992, BRIT J SURG, V79, P1080, DOI 10.1002/bjs.1800791031
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NR 37
TC 41
Z9 50
U1 0
U2 6
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAY
PY 2015
VL 100
IS 5
BP 934
EP 941
DI 10.9738/INTSURG-D-15-00036.1
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CJ0UF
UT WOS:000355193300028
PM 25859652
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Vos, RJ
   Yilmaz, A
   Sonker, U
   Kelder, JC
   Kloppenburg, GTL
AF Vos, Roemer J.
   Yilmaz, Alaaddin
   Sonker, Uday
   Kelder, Johannes C.
   Kloppenburg, Geoffrey T. L.
TI Vacuum-assisted closure of post-sternotomy mediastinitis as compared to
   open packing
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure; Mediastinitis; Infection; Sternotomy
ID STERNAL WOUND-INFECTION; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   POSTOPERATIVE MEDIASTINITIS; THERAPY; SURVIVAL; SURGERY
AB Post-sternotomy mediastinitis is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. The aim of this study is to describe clinical outcomes of VAC as compared to open packing and to predict risk factors for mortality. We performed a retrospective analysis of 113 patients with mediastinitis undergoing VAC (n = 89) or open packing (n = 24) between January 2000 and July 2010. Patient characteristics, risk factors and procedure-related variables were analysed. C-reactive protein and leukocyte counts were determined on admission and at regular intervals during hospital stay. We compared length of treatment, treatment failure, hospital stay and mortality. We also analysed risk factors predicting mortality. In-hospital mortality in the VAC group was 12.4% compared to 41.7% in the conventional group (P = 0.0032). Intensive care stay was 6.8 +/- 14.4 days with VAC therapy compared to 18.5 +/- 21.0 days with open packing (P = 0.0081). Significant risk factors for mortality were pre-operative renal failure and obesity. Our findings indicate that VAC therapy is superior to open packing, resulting in shorter intensive care stay and improved survival.
C1 [Vos, Roemer J.; Yilmaz, Alaaddin; Sonker, Uday; Kloppenburg, Geoffrey T. L.] St Antonius Hosp, Dept Cardiothorac Surg, Nieuwegein, Netherlands.
   [Kelder, Johannes C.] St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.
C3 St. Antonius Hospital Utrecht; St. Antonius Hospital Utrecht
RP Kloppenburg, GTL (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Nieuwegein, Netherlands.
EM geoffrey_kloppenburg@hotmail.com
OI Vos, Roemer/0000-0002-2511-988X
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NR 15
TC 37
Z9 46
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JAN
PY 2012
VL 14
IS 1
BP 17
EP 20
DI 10.1093/icvts/ivr049
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 025GD
UT WOS:000310174000005
PM 22108946
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Katz, MS
   Finck, CM
   Schwartz, MZ
   Moront, ML
   Prasad, R
   Timmapuri, SJ
   Arthur, LG
AF Katz, Michael S.
   Finck, Christine M.
   Schwartz, Marshall Z.
   Moront, Matthew L.
   Prasad, Rajeev
   Timmapuri, Shaheen J.
   Arthur, L. Grier
TI Vacuum-assisted closure in the treatment of extensive lymphangiomas in
   children
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 58th Annual Meeting of the British-Association-of-Paediatric-Surgeons
CY JUL 19-22, 2011
CL Belfast, NORTH IRELAND
SP British Assoc Paediat Surg
DE Lymphangioma; Cystic hygroma; Vacuum-assisted closure
ID PRESSURE WOUND THERAPY; LYMPHATIC MALFORMATIONS; SCLEROTHERAPY;
   FOUNDATION; EXPERIENCE
AB Background: The management of lymphangiomas in children is a complex problem with frequent recurrence and infection. Vacuum-assisted closure (VAC) devices have been shown to accelerate the healing of open wounds. We hypothesized that VAC therapy might decrease complications after resection of lymphangiomas.
   Methods: A retrospective review was performed on 13 children (August 2005 to April 2010) who were patients undergoing lymphangioma resection with postoperative VAC therapy. Patient demographics, size and location of the lymphangioma, VAC duration and number of changes, hospital stay, complications, need for further surgery, and length of follow-up were recorded.
   Results: Thirteen children (mean age, 8 years; mean weight, 34 kg) underwent 15 operations for lymphangiomas followed by postoperative VAC therapy. Locations included the head and neck, thorax and abdomen, and lower extremity. The mean VAC duration was 19 days, and they underwent a mean of 2.6 VAC changes. Six children had operative closure of the wound at a mean of 15 days postoperative. The remaining patients underwent closure by secondary intention. There were no recurrences. Complications included VAC device malfunctions requiring intervention and wound infections. Mean follow-up was 289 days.
   Conclusion: Postoperative VAC therapy for the treatment of lymphangiomas can be an effective adjunct to surgical treatment by decreasing risks of recurrence and infection. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Katz, Michael S.; Schwartz, Marshall Z.; Moront, Matthew L.; Prasad, Rajeev; Timmapuri, Shaheen J.; Arthur, L. Grier] Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat Gen Thorac & Minimally Invas Surg, Philadelphia, PA 19134 USA.
   [Finck, Christine M.] Univ Connecticut, Sch Med, Dept Pediat Surg, Connecticut Childrens Med Ctr, Hartford, CT 06112 USA.
C3 Drexel University; Connecticut Children's Medical Center; University of
   Connecticut
RP Arthur, LG (通讯作者)，Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat Gen Thorac & Minimally Invas Surg, Philadelphia, PA 19134 USA.
EM Grier.arthur@tenethealth.com
OI Finck, Christine/0000-0003-1771-7844
CR Alomari AI, 2006, J VASC INTERV RADIOL, V17, P1639, DOI 10.1097/01.RVI.0000239104.78390.E5
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NR 19
TC 19
Z9 20
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD FEB
PY 2012
VL 47
IS 2
BP 367
EP 370
DI 10.1016/j.jpedsurg.2011.11.030
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA 894GR
UT WOS:000300415600025
PM 22325392
DA 2026-07-24
ER

PT J
AU Eksi, M
   Arikan, Y
   Simsek, A
   Ozdemir, O
   Karadag, S
   Gurbuz, N
   Sahin, S
   Tasci, AI
AF Eksi, Mithat
   Arikan, Yusuf
   Simsek, Abdulmuttalip
   Ozdemir, Osman
   Karadag, Serdar
   Gurbuz, Necati
   Sahin, Selcuk
   Tasci, Ali Ihsan
TI Factors affecting length of stay in Fournier's gangrene: a retrospective
   analysis of 10 years' data
SO AKTUELLE UROLOGIE
LA English
DT Article
DE Fournier's gangrene; mortality; risk factors; length of stay; Fourniers
   Gangran; Mortalitat; Dauer des Aufenthalts; Risikofaktoren
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED CLOSURE; NECROTIZING
   FASCIITIS; OUTCOME PREDICTION; SCORING SYSTEMS; MANAGEMENT; MORTALITY;
   IMPACT
AB Zusammenfassung
C1 [Eksi, Mithat; Arikan, Yusuf; Simsek, Abdulmuttalip; Ozdemir, Osman; Karadag, Serdar; Gurbuz, Necati; Sahin, Selcuk; Tasci, Ali Ihsan] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Urol, Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Eksi, M (通讯作者)，Bakirkoy Dr Sadi Konuk Training & Res Hosp, Urol, Istanbul, Turkey.
EM mithat_eksi@hotmail.com
RI Taşçı, Ali iihsan/JMP-9487-2023; Ekşi, Mithat/GPX-2121-2022; Sahin,
   Selcuk/AEP-0805-2022; Arikan, Yusuf/AGM-6388-2022; Karadağ,
   Serdar/PJB-6385-2026
OI Taşçı, Ali iihsan/0000-0002-6943-6676; 
CR [Anonymous], 1764, J MED CHIR PHARM
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NR 33
TC 7
Z9 9
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0001-7868
EI 1438-8820
J9 AKTUEL UROL
JI Aktuelle Urol.
PD JUN
PY 2022
VL 53
IS 03
BP 262
EP 268
DI 10.1055/a-1260-2576
EA OCT 2020
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 2R7NE
UT WOS:000580543800001
PM 33086391
DA 2026-07-24
ER

PT J
AU Matsuzaki, K
   Miyamoto, A
AF Matsuzaki, Kyoichi
   Miyamoto, Akira
TI Limb Salvage with Multiple Modalities: A Case Report of a Diabetic Heel
   Ulcer Associated with Peripheral Arterial Disease
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE diabetic heel ulcer; endovascular therapy; maggot therapy;
   negative-pressure wound therapy; partial calcanectomy; peripheral
   arterial disease
ID LUCILIA-SERICATA-LARVAE; PRESSURE WOUND THERAPY
AB A large diabetic heel ulcer with peripheral arterial disease is an independent predictor of limb loss; below-knee amputation is not uncommon in such cases. One treatment is multimodal therapy, which includes partial calcanectomy. Because there is a limit to the ulcer surface area that can be sutured after partial calcanectomy, the remaining raw surface is treated with another method. In this case report, the authors describe a patient with peripheral arterial disease who had a 7 x 9-cm diabetic heel ulcer. The patient was treated with partial calcanectomy after catheter-based endovascular therapy revascularization and then maggot therapy after residual-wound dimensions were reduced by negative-pressure wound therapy.
C1 [Matsuzaki, Kyoichi] Int Univ Hlth & Welf, Sch Med, Dept Plast & Reconstruct Surg, Chiba, Japan.
   [Miyamoto, Akira] Takatsu Gen Hosp, Cardiovasc Ctr, Kawasaki, Kanagawa, Japan.
C3 International University of Health & Welfare
RP Matsuzaki, K (通讯作者)，Int Univ Hlth & Welf, Sch Med, Dept Plast & Reconstruct Surg, Chiba, Japan.
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NR 11
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2022
VL 35
IS 7
DI 10.1097/01.ASW.0000831072.30829.15
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 2F9XR
UT WOS:000813255900004
PM 35723963
DA 2026-07-24
ER

PT J
AU Fujiwara, H
   Irisawa, R
   Otsuka, M
   Kako, T
   Kaji, T
   Kadono, T
   Koga, M
   Hirosaki, K
   Nokita, Y
   Asano, Y
   Nakanishi, T
   Maekawa, T
   Motegi, SI
   Yoshino, Y
   Hasegawa, M
   Fujimoto, M
   Tachibana, T
AF Fujiwara, Hiroshi
   Irisawa, Ryokichi
   Otsuka, Masaki
   Kako, Tomoko
   Kaji, Tatsuya
   Kadono, Takafumi
   Koga, Monji
   Hirosaki, Kuninori
   Nokita, Yoko
   Asano, Yoshihide
   Nakanishi, Takeshi
   Maekawa, Takeo
   Motegi, Sei-ichiro
   Yoshino, Yuichiro
   Hasegawa, Minoru
   Fujimoto, Manabu
   Tachibana, Takao
CA Wound Pressure Ulcer Burn Guidelines Drafting Comm
   Pressure Ulcer Grp
TI Wound, Pressure Ulcer, and Burn Guidelines (2023)-2: Guidelines for the
   Diagnosis and Treatment of Pressure Ulcers, Third Edition
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE debridement; decubitus; dressings; GRADE; meta-analysis;
   negative-pressure wound therapy; pressure ulcers; systematic review;
   topical medication
ID FIBROBLAST-GROWTH-FACTOR; RANDOMIZED CLINICAL-TRIAL; RISK-ASSESSMENT
   SCALES; DEEP TISSUE-INJURY; SILVER SULFADIAZINE; COST-EFFECTIVENESS;
   FOOT ULCERS; DESIGN-R; STAGE-II; ELECTRICAL-STIMULATION
AB Guidelines for the diagnosis and treatment of pressure ulcers, third edition, is a fully revised guidelines drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in a systematic and transparent manner with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. In the four clinical questions with meta-analyses, debridement, topical medication, dressings, and negative-pressure wound therapy were weakly recommended in the treatment of pressure ulcers. General information on diagnosis, prevention, assessment, and unconventional treatment of pressure ulcers was also provided.
C1 [Fujiwara, Hiroshi] Niigata Univ, Niigata, Japan.
   [Irisawa, Ryokichi] Tokyo Med Univ, Shinjuku Ku, Tokyo, Japan.
   [Otsuka, Masaki] Chutoen Gen Med Ctr, Kakegawa, Japan.
   [Kako, Tomoko] Mie Prefectural Gen Med Ctr, Yokaichi, Japan.
   [Kaji, Tatsuya] Hiroshima City Hiroshima Citizens Hosp, Hiroshima, Japan.
   [Kadono, Takafumi; Nokita, Yoko] St Marianna Univ, Sch Med, Kawasaki, Japan.
   [Koga, Monji] Fukuoka Univ, Fukuoka, Japan.
   [Hirosaki, Kuninori] Hokkaido Med Ctr, Sapporo, Japan.
   [Asano, Yoshihide] Tohoku Univ, Sendai, Japan.
   [Nakanishi, Takeshi] Meiji Univ Integrat Med, Nantan, Japan.
   [Maekawa, Takeo] Jichi Med Univ, Saitama Med Ctr, Saitama, Japan.
   [Motegi, Sei-ichiro] Gunma Univ, Maebashi, Japan.
   [Yoshino, Yuichiro] Japanese Red Cross Kumamoto Hosp, Kumamoto, Japan.
   [Hasegawa, Minoru] Univ Fukui, Fukui, Japan.
   [Fujimoto, Manabu] Osaka Univ, Suita, Japan.
   [Tachibana, Takao] Hoshigaoka Med Ctr, Hirakata, Japan.
C3 Niigata University; Tokyo Medical University; Hiroshima City Hospital;
   St Marianna University; Fukuoka University; Tohoku University; Jichi
   Medical University; Gunma University; University of Fukui; University of
   Osaka
RP Fujiwara, H (通讯作者)，Niigata Univ, Niigata, Japan.
EM hfujiwar@med.niigata-u.ac.jp
RI ; Fujimoto, Manabu/AHA-3461-2022
OI IRISAWA, Ryokichi/0000-0002-9095-3192; Asano,
   Yoshihide/0000-0001-5560-9778; 
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NR 285
TC 0
Z9 0
U1 9
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD SEP
PY 2025
VL 52
IS 9
BP e744
EP e794
DI 10.1111/1346-8138.17758
EA JUN 2025
PG 51
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 7ET7A
UT WOS:001517230400001
PM 40569688
OA Bronze
DA 2026-07-24
ER

PT J
AU White, AJ
   Gilad, R
   Motivala, S
   Fiani, B
   Rasouli, J
AF White, Alexandra Jeanne
   Gilad, Ronit
   Motivala, Soriaya
   Fiani, Brian
   Rasouli, Jonathan
TI Negative Pressure Wound Therapy in Spinal Surgery
SO BIOENGINEERING-BASEL
LA English
DT Review
DE spine surgery; surgical site infection; wound management; wound
   dressing; infection prevention; wound healing
AB Negative pressure wound therapy (NPWT) has demonstrated promise in the management of surgical site infections as well as assisting in surgical wound healing. In this manuscript, we describe the mechanisms and applications of NPWT for surgical wounds and existing evidence for NPWT in cardiac, plastic, and general surgery, followed by a discussion of the emerging evidence base for NPWT in spinal surgery. We also discuss the different applications of NPWT for open wounds and closed incisions, and the promise of newer closed-incision NPWT (ciNPWT) devices. There is nominal but promising prospective evidence on NPWT's efficacy in select at-risk populations for post-operative wound complications after spinal surgery. As there is currently a paucity of robust clinical evidence on its efficacy, rigorous randomized prospective clinical trials are needed.
C1 [White, Alexandra Jeanne] Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin, Cleveland, OH 44195 USA.
   [Gilad, Ronit; Motivala, Soriaya; Rasouli, Jonathan] Staten Isl Univ Hosp, Northwell Hlth, Staten Isl, NY 10301 USA.
   [Fiani, Brian] New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Neurosurg, New York, NY 10065 USA.
C3 Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University; Northwell Health; Cornell University; Weill Cornell
   Medical Center; Weill Cornell Medicine; NewYork-Presbyterian Hospital
RP Rasouli, J (通讯作者)，Staten Isl Univ Hosp, Northwell Hlth, Staten Isl, NY 10301 USA.
EM jrasouli1@northwell.edu
RI ; Rasouli, Jonathan/AAF-2742-2020
OI White, Alexandra/0000-0003-4704-6578; 
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NR 61
TC 10
Z9 10
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-5354
J9 BIOENGINEERING-BASEL
JI Bioengineering-Basel
PD NOV
PY 2022
VL 9
IS 11
AR 614
DI 10.3390/bioengineering9110614
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6B0IP
UT WOS:000881028300001
PM 36354525
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Crew, JR
   Varilla, R
   Rocas, TA
   Rani, SA
   Debabov, D
AF Crew, John R.
   Varilla, Randell
   Rocas, Thomas Allandale, III
   Rani, Suriani Abdul
   Debabov, Dmitri
TI Treatment of Acute Necrotizing Fasciitis Using Negative Pressure Wound
   Therapy and Adjunctive NeutroPhase Irrigation Under the Foam
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure; necrotizing fasciitis; hypochlorous acid;
   debridement; tissue repair
ID HYPOCHLOROUS ACID; N-CHLOROTAURINE; MECHANISMS
AB Necrotizing fasciitis is a complication of a bacterial infection that activates the immune system in perifascial planes. This case report high-lights initial diagnostic failures that delay early treatment, which causes profoundly negative consequences. Antimicrobial control with abolition of the inciting bacteria does not neutralize the subsequent endopathologic ravages. A new therapeutic technique, which combines negative pressure wound therapy (NPVVT) and a pure hypochlorous acid solution 0.01% (NeutroPhase, NovaBay Pharmaceuticals Inc, Emeryville, CA) along with debridement and antibiotics is described in this study. It is believed that the combination of neutralization of the toxins produced by bacteria with NeutroPhase along with the NPWT action of removing exudates is effective in saving the patient.
C1 [Crew, John R.; Varilla, Randell; Rocas, Thomas Allandale, III] Seton Med Ctr, Daly City, CA 94015 USA.
   [Rani, Suriani Abdul; Debabov, Dmitri] NovaBay Pharmaceut Inc, Emeryville, CA USA.
RP Crew, JR (通讯作者)，Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
EM jcrewmd@att.net
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NR 17
TC 14
Z9 16
U1 0
U2 11
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2013
VL 25
IS 10
BP 272
EP 277
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 249KO
UT WOS:000326776300004
PM 25867517
DA 2026-07-24
ER

PT J
AU Beckman, M
   Paul, J
   Neideen, T
   Weigelt, JA
AF Beckman, Marshall
   Paul, Jasmeet
   Neideen, Todd
   Weigelt, John A.
TI Role of the Open Abdomen in Critically Ill Patients
SO CRITICAL CARE CLINICS
LA English
DT Article
DE Open abdomen; Abdominal compartment syndrome; Temporary abdominal
   closure; Negative pressure wound therapy; Retroperitoneal Hemorrhage;
   Intra-abdominal infections; Damage control surgery
ID ABDOMINAL COMPARTMENT SYNDROME; PRESSURE WOUND THERAPY; DAMAGE-CONTROL;
   INTRAABDOMINAL HYPERTENSION; FASCIAL CLOSURE; TRAUMA PATIENTS;
   MANAGEMENT; GUIDELINES; DRAINAGE; VACUUM
AB An open abdomen is common used in critically ill patients to temporize permanent abdominal closure. The most common reason for leaving the abdomen open by reopening a laparotomy, not closing, or creating a fresh laparotomy is the abdominal compartment syndrome. The open abdomen technique is also used in damage control operations and intra-abdominal sepsis. Negative pressure wound therapy may be associated with better outcomes than other temporary abdominal closure techniques. The open abdomen is associated with many early and late complications, including infections, gastrointestinal fistulas, and ventral hernias. Clinicians should be vigilant regarding the development of these complications.
C1 [Beckman, Marshall; Paul, Jasmeet; Neideen, Todd; Weigelt, John A.] Med Coll Wisconsin, Dept Surg, Div Trauma Surg & Crit Care, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Weigelt, JA (通讯作者)，Med Coll Wisconsin, Dept Surg, Div Trauma Surg & Crit Care, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
EM jweigelt@mcw.edu
RI /AGQ-2011-2022
OI Paul, Jasmeet/0000-0002-4030-6624
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NR 57
TC 21
Z9 28
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0704
EI 1557-8232
J9 CRIT CARE CLIN
JI Crit. Care Clin.
PD APR
PY 2016
VL 32
IS 2
BP 255
EP +
DI 10.1016/j.ccc.2015.12.003
PG 11
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DJ7BN
UT WOS:000374367000009
PM 27016166
DA 2026-07-24
ER

PT J
AU Fu, SQ
   Panayi, A
   Fan, JC
   Mayer, HF
   Daya, M
   Khouri, RK
   Gurtner, GC
   Ogawa, R
   Orgill, DP
AF Fu, Siqi
   Panayi, Adriana
   Fan, Jincai
   Mayer, Horacio F.
   Daya, Mahendra
   Khouri, Roger K.
   Gurtner, Geoffrey C.
   Ogawa, Rei
   Orgill, Dennis P.
TI Mechanotransduction in Wound Healing: From the Cellular and Molecular
   Level to the Clinic
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE adipocytes; fibroblasts; keratinocytes; mechanical forces;
   mechanotransduction; negative-pressure wound therapy; scar; skin taping;
   tissue expander; wound healing
AB Skin provides a critical protective barrier for humans that is often lost following burns, trauma, or resection. Traditionally, skin loss is treated with transfer of tissue from other areas of the body such as a skin graft or flap. Mechanical forces can provide powerful alternatives and adjuncts for skin replacement and scar modulation. This article first provides an overview of the various mechanical forces that affect fibroblasts, keratinocytes, endothelial cells, and adipocytes at the cellular and molecular level. This is followed by a review of the mechanical devices currently in clinical use that can substantially augment the restoration of skin integrity and reduce scarring. Methods described include tissue expanders, external volume expansion, negative-pressure wound therapy, and skin taping.
C1 [Fu, Siqi] Second Ziangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.
   [Panayi, Adriana] Harvard Med Sch, Boston, MA 02115 USA.
   [Fan, Jincai] Peking Union Med Coll, Plast Surg Hosp, Beijing, Peoples R China.
   [Mayer, Horacio F.] Univ Buenos Aires, Plast Surg Dept, Hosp Italian Buenos Aires, Sch Med, Buenos Aires, DF, Argentina.
   [Mayer, Horacio F.] Hosp Italiano Buenos Aires Univ Inst, Buenos Aires, DF, Argentina.
   [Daya, Mahendra] Univ Kwazulu, Nelson R Mandela Sch Med, Dept Plast & Reconstruct Surg, Natal, South Africa.
   [Khouri, Roger K.] Miami Breast Ctr, Key Biscayne, FL USA.
   [Gurtner, Geoffrey C.] Stanford Univ, Dept Surg, Sch Med, Surg,Div Plast & Reconstruct Surg, Stanford, CA USA.
   [Ogawa, Rei] Nippon Med Coll Hosp, Dept Plast Reconstruct & Aesthet Surg, Tokyo, Japan.
   [Orgill, Dennis P.] Harvard Med Sch, Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Plastic Surgery Hospital -
   CAMS; Peking Union Medical College; University of Buenos Aires; Hospital
   Italiano de Buenos Aires; University of Kwazulu Natal; Stanford
   University; Nippon Medical School; Harvard University; Harvard Medical
   School
RP Fu, SQ (通讯作者)，Second Ziangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China.
RI Mayer, Horacio F/AAE-4645-2020; Khouri, Roger/I-2799-2019; Orgill,
   Dennis/H-7596-2019; Panayi, Adriana/HHT-0513-2022
OI Mayer, Horacio F/0000-0002-3586-8657; Khouri, Roger/0000-0002-1848-3149;
   Daya, Mahena/0000-0002-1309-7126; Panayi, Adriana/0000-0003-4053-9855
FU Acelity
FX The authors thank The Gillian Reny Stepping Strong Center for Trauma
   Innovation for the generous donation to the Tissue Engineering and Wound
   Healing Laboratory that helped accomplish this work. Dr Orgill has
   disclosed that he is a consultant to and recipient of grant research
   funding from Acelity, but that his spouse/life partner (if any) has no
   financial relationships with, or financial interests in, any commercial
   organizations relevant to this educational activity. Lippincott CME
   Institute and Lippincott Professional Development have identified and
   resolved all conflicts of interest concerning this educational activity.
   The remaining authors, faculty, staff, and planners, including
   spouses/partners (if any), in any position to control the content of
   this CME/NCPD activity have disclosed that they have no financial
   relationships with, or financial interests in, any commercial companies
   relevant to this educational activity. To earn CME credit, you must read
   the CME article and complete the quiz online, answering at least 7 of
   the 10 questions correctly. This continuing educational activity will
   expire for physicians on January 31, 2023, and for nurses December 2,
   2022. All tests are now online only; take the test at http://cme.lww.com
   for physicians and www.NursingCenter.com/CE/ASWC for nurses. Complete
   NCPD/CME information is on the last page of this article.
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NR 57
TC 22
Z9 30
U1 2
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2021
VL 34
IS 2
BP 67
EP 74
DI 10.1097/01.ASW.0000725220.92976.a7
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA QE8XK
UT WOS:000616488200008
PM 33443911
DA 2026-07-24
ER

PT J
AU Mhatre, P
   Huang, M
   Cohler, M
AF Mhatre, Priya
   Huang, Mark
   Cohler, Marissa
TI Autonomic Dysreflexia With Negative-Pressure Wound Therapy: A Report of
   Two Cases
SO PM&R
LA English
DT Article
ID SPINAL-CORD-INJURY; ULCER RISK-FACTORS; TOXICITY; LIDOCAINE
AB Pressure ulcers and autonomic dysreflexia (AD) are common complications that may affect individuals with spinal cord injury (SCI). Negative-pressure wound therapy (NPWT) is a frequently used modality to aid in wound healing in the treatment of pressures ulcers in patients with SCI. Although the common triggers of AD have been well described in the literature, there have been no formal reports of NPWT itself as a cause of AD. We detail 2 cases of patients with SCI and with AD thought to be secondary to NPWT and discuss modifications made to allow for continued treatment with NPWT while minimizing further episodes of AD. We propose that NPWT should be considered as a potential source of AD in patients with SCI undergoing this therapy. PM R2013;5:238-241
C1 [Mhatre, Priya; Huang, Mark; Cohler, Marissa] Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Dept Phys Med & Rehabil, Chicago, IL 60611 USA.
C3 Shirley Ryan AbilityLab; Northwestern University; Feinberg School of
   Medicine
RP Huang, M (通讯作者)，Northwestern Univ, Feinberg Sch Med, Rehabil Inst Chicago, Dept Phys Med & Rehabil, 345 E Super St, Chicago, IL 60611 USA.
EM mhuang@ric.org
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NR 15
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD MAR
PY 2013
VL 5
IS 3
BP 238
EP 241
DI 10.1016/j.pmrj.2012.11.008
PG 4
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA 110HN
UT WOS:000316433300015
PM 23481332
DA 2026-07-24
ER

PT J
AU Gupta, A
   Gupta, A
   Ravi, B
   Mundra, M
   Sandhu, H
   Agrawal, S
   Anjum, R
AF Gupta, Ashish
   Gupta, Amit
   Ravi, Bina
   Mundra, Mukund
   Sandhu, Harindra
   Agrawal, Saumya
   Anjum, Rohik
TI Post-traumatic necrotising fasciitis of the breast: a case study with
   literature review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE breast; necrotising fasciitis; negative pressure wound therapy
ID SOFT-TISSUE INFECTION; RARE
AB Necrotising fasciitis is a rare infection of the skin and underlying soft tissue. It primarily involves the extremities and rarely the breast. Primary necrotising fasciitis of the breast in a non-lactating, healthy female is rarer still. The authors present the case report of a patient presenting with primary necrotising fasciitis of the breast after sustaining a penetrating injury. The patient was managed successfully with serial debridement and negative pressure wound therapy (NPWT). To our knowledge only 19 such cases have been reported in the indexed literature so far. This is also the eighth case globally of primary necrotising fasciitis of the breast in a non-lactating female without any associated immunosuppression, which is the basis of reporting this case.
C1 [Gupta, Ashish; Gupta, Amit; Ravi, Bina; Mundra, Mukund; Sandhu, Harindra; Agrawal, Saumya; Anjum, Rohik] AIIMS, Dept Gen Surg, Rishikesh 249203, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Gupta, A (通讯作者)，AIIMS, Dept Gen Surg, Rishikesh 249203, India.
EM Drashish0403@gmail.com
RI Gupta, Amit/AAH-6340-2019
OI Anjum T Siddeek, Rohik/0000-0002-6106-2630; RAVI,
   BINA/0000-0001-8894-6674; GUPTA, AMIT KUMAR/0009-0008-9033-6080
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NR 31
TC 8
Z9 11
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2019
VL 28
IS 11
BP 775
EP 778
DI 10.12968/jowc.2019.28.11.775
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JM9YA
UT WOS:000496560300009
PM 31721667
DA 2026-07-24
ER

PT J
AU Kim, PJ
   Attinger, CE
AF Kim, Paul J.
   Attinger, Christopher E.
TI Negative-Pressure Wound Therapy With Instillation: A Tool in the
   Multidisciplinary Approach to Limb Function Preservation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ANTISEPTIC SOLUTION; CARE; AMPUTATION; OUTCOMES; FOAM; AMBULATION;
   IMPACT; SALINE
AB The multidisciplinary approach to lower extremity function preservation is well established and is globally considered the standard of care. Every member of the team contributes their unique skills and knowledge to patient care. The effective integration of negative-pressure wound therapy with instillation (NPWTi) has fundamentally changed the approach to the infected or contaminated wound. Initially, in conjunction with excisional debridement, NPWTi has demonstrated its utility of expediting wound bed preparation for closure or coverage. With the introduction of a novel foam design, the effectiveness has increased and provided an option in cases where surgical intervention is not available or recommended. The successful implementation and continued monitoring of NPWTi provides an efficient tool to expedite ultimate wound healing and involves all members of the team.
C1 Univ Texas Southwestern, Dept Plast Surg & Orthoped Surg, Dallas, TX 75390 USA.
   MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Georgetown University
RP Kim, PJ (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Outpatient Bldg,1801 Inwood Rd, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
OI , Paul/0000-0002-6186-6890
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   Kim PJ, 2016, PLAST RECONSTR SURG, V138, p241S, DOI 10.1097/PRS.0000000000002648
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NR 45
TC 5
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 27S
EP 33S
DI 10.1097/PRS.0000000000007608
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500006
PM 33347060
DA 2026-07-24
ER

PT J
AU Tarkin, IS
   Clare, MP
   Marcantonio, A
   Pape, HC
AF Tarkin, I. S.
   Clare, M. P.
   Marcantonio, A.
   Pape, H. C.
TI An update on the management of high-energy plion fractures
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE piton fracture; plafond fracture; distal tibia fracture; biological
   plating; vacuum assisted; closure device
ID TIBIAL PILON FRACTURES; VACUUM-ASSISTED CLOSURE; INTERNAL-FIXATION;
   EXTERNAL FIXATION; PLAFOND FRACTURES; OPEN REDUCTION; DISTAL TIBIA;
   INTRAARTICULAR FRACTURE; ARTICULAR-CARTILAGE; TREATMENT PROTOCOL
AB High energy piton fractures present a unique challenge to the patient and orthopaedic surgeon. Care for the soft tissue envelope is as important as management of this articular fracture. This article reviews the fundamental principles for treatment of the patient with severe piton fracture. Staged operative care is emphasised to prevent wound and infectious complications which have historically plagued piton fracture surgery. New innovations directed at improving results are discussed including biological planting and wound care using the vacuum assisted closure device. Lastly, validated outcomes are presented which highlight the severity of these injuries despite optimal care. (c) 2007 Elsevier Ltd. All rights reserved.
C1 [Tarkin, I. S.; Marcantonio, A.; Pape, H. C.] Univ Pittsburgh, Med Ctr, Div Orthopaed Traumatol, Pittsburgh, PA 15213 USA.
   [Clare, M. P.] Florida Orthopaed Inst, Div Foot & Ankle Surg, Tampa, FL USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Florida Orthopaedic Institute
RP Tarkin, IS (通讯作者)，Univ Pittsburgh, Med Ctr, Div Orthopaed Traumatol, 3471 5th Ave, Pittsburgh, PA 15213 USA.
EM tarkinis@upmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
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   [No title captured]
NR 57
TC 76
Z9 102
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2008
VL 39
IS 2
BP 142
EP 154
DI 10.1016/j.injury.2007.07.024
PG 13
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 268UV
UT WOS:000253606200001
PM 18054017
DA 2026-07-24
ER

PT J
AU Chatzoulis, G
   Chatzoulis, K
   Spyridopoulos, P
   Pappas, P
   Ploumis, A
AF Chatzoulis, G.
   Chatzoulis, K.
   Spyridopoulos, P.
   Pappas, P.
   Ploumis, A.
TI Salvage of an infected titanium mesh in a large incisional ventral
   hernia using medicinal honey and vacuum-assisted closure: a case report
   and literature review
SO HERNIA
LA English
DT Review
DE Hernia repair; Infection; MRSA; Prosthetic mesh; Honey
ID REPAIR; COMPLICATIONS; PROPHYLAXIS; BACTERIA; EFFICACY; WOUNDS; TRIAL;
   MODEL
AB The overall reported percentage of mesh infections is 1.3%. Infections after incisional ventral hernia repair depend on many factors. Salvaging an infected mesh should be the priority, because serious complications are reported following mesh removal. In this case report, a methicillin-resistant Staphylococcus aureus (MRSA)-infected titanium mesh was salvaged by a novel technique, not requiring removal. The combination of vacuum-assisted closure (VAC (TM) therapy) of the wound and medical honey (L-Mesitran (TM)) proved to be successful in leaving the mesh in situ. We report the successful management of this infected titanium mesh and review the literature regarding the possible pathogenetic mechanisms and treatment options.
C1 [Chatzoulis, G.; Chatzoulis, K.; Spyridopoulos, P.; Pappas, P.] 424 Gen Mil Hosp, Dept Surg 1, Thessaloniki, Greece.
   [Ploumis, A.] Univ Ioannina, Dept Orthopaed & Rehabil, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Chatzoulis, G (通讯作者)，424 Gen Mil Hosp, Dept Surg 1, Eukarpias Ave,VST 903, Thessaloniki, Greece.
EM surgchatz@yahoo.gr; kxatzo@yahoo.gr; pdsdoc@the.forthnet.gr;
   vasilaki@med.auth.gr; aploumis@cc.uoi.gr
OI Ploumis, Avraam/0000-0002-6828-3196
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NR 27
TC 13
Z9 14
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD AUG
PY 2012
VL 16
IS 4
BP 475
EP 479
DI 10.1007/s10029-010-0767-8
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 986IL
UT WOS:000307335200018
PM 21191626
DA 2026-07-24
ER

PT J
AU Canter, HI
   Isci, E
   Erk, Y
AF Canter, Halit Ibrahim
   Isci, Evren
   Erk, Yucel
TI Vacuum-assisted wound closure for the management of a foot ulcer due to
   Buerger's disease
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Buerger's disease; Vacuum-assisted closure; Foot ulcer; Neural island
   flap
ID THROMBOANGIITIS-OBLITERANS; FLAP COVERAGE; PATIENT
AB Thromboangiitis obliterans is a segmental inflammatory disease of the small- and medium-sized vessels mainly affecting the extremities. Although there are numerous reports concerning the treatment of these debilitating, chronic ulcers, such as skin grafting, local flaps, and free flaps, this report is the first published case of a patient with Buerger's disease, successfully managed with vacuum-assisted closure (VAC) application. This therapy decreases the period of hospital stay and increases patient comfort between dressings. Further clinical studies are needed to demonstrate the effectiveness and safety of VAC therapy in treatment of ulcers due to different kinds of vasculitis. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Canter, Halit Ibrahim; Isci, Evren; Erk, Yucel] Hacettepe Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-06100 Ankara, Turkey.
C3 Hacettepe University
RP Canter, HI (通讯作者)，Providence Hosp, Craniofacial Inst, Flour Fisher Ctr 3, 16001 W 9 Mite Rd,3rd Flour, Providence, MI 48075 USA.
EM hicanter@gmail.com
RI Canter, Halil Ibrahim/AFW-3691-2022; isci, evren tevfik/GYA-5663-2022
OI Canter, Halil Ibrahim/0000-0002-0329-5161; 
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   OLIN JW, 2006, CURR OPIN RHEUMATOL, V8, P8
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NR 16
TC 0
Z9 2
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD FEB
PY 2009
VL 62
IS 2
BP 250
EP 253
DI 10.1016/j.bjps.2007.09.031
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 410QZ
UT WOS:000263594500019
PM 17980686
DA 2026-07-24
ER

PT J
AU Schipper, P
   Tieu, BH
AF Schipper, Paul
   Tieu, Brandon H.
TI Acute Chest Wall Infections Surgical Site Infections, Necrotizing Soft
   Tissue Infections, and Sternoclavicular Joint Infection
SO THORACIC SURGERY CLINICS
LA English
DT Article
DE Surgical site infections; SSI; Wound infection; Necrotizing soft tissue
   infection; Necrotizing fasciitis; Sternoclavicular joint infection;
   Sternoclavicular pyoarthrosis
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE COMPLICATIONS; SMOKING-CESSATION;
   LUNG-CANCER; INTRATHORACIC APPLICATION; NEGATIVE-PRESSURE; MANAGEMENT;
   THERAPY; RESECTION; EMPYEMA
AB Acute chest wall infections are uncommon and share similar risk factors for infection at other surgical sites. Smoking cessation has been shown to decrease the risk of surgical site infection. Depending on the depth of infection and/or involvement of the organ space, adequate therapy involves antibiotics and drainage. Early diagnosis and debridement of necrotizing soft tissue infections is essential to reduce mortality. Sternoclavicular joint infections require surgical debridement, en bloc resection, and antibiotic therapy. A standard approach to wound closure after resection has yet to be established. Vacuum-assisted closure is a valuable adjunct to standard therapy.
C1 [Schipper, Paul; Tieu, Brandon H.] Oregon Hlth & Sci Univ, Dept Surg, Div Cardiothorac Surg, Sect Gen Thorac Surg, 3181 SW Sam Jackson Pk Rd L353, Portland, OR 97239 USA.
C3 Oregon Health & Science University
RP Schipper, P (通讯作者)，Oregon Hlth & Sci Univ, Dept Surg, Div Cardiothorac Surg, Sect Gen Thorac Surg, 3181 SW Sam Jackson Pk Rd L353, Portland, OR 97239 USA.
EM schippep@ohsu.edu
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   Puri V, 2011, ANN THORAC SURG, V91, P257, DOI 10.1016/j.athoracsur.2010.07.112
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   Renfree KJ, 2003, CLIN SPORT MED, V22, P219, DOI 10.1016/S0278-5919(02)00104-7
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   Ross JJ, 2004, MEDICINE, V83, P139, DOI 10.1097/01.md.0000126761.83417.29
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Sarani B, 2009, J AM COLL SURGEONS, V208, P279, DOI 10.1016/j.jamcollsurg.2008.10.032
   Song HK, 2002, ANN THORAC SURG, V73, P427, DOI 10.1016/S0003-4975(01)03390-2
   Sorensen LT, 2003, ANN SURG, V238, P1, DOI 10.1097/01.SLA.0000074980.39700.31
   Sziklavari Z, 2015, EUR J CARDIO-THORAC, V48, pE9, DOI 10.1093/ejcts/ezv186
   Thomsen T, 2009, BJS-BRIT J SURG, V96, P451, DOI 10.1002/bjs.6591
   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
   Welvaart Willem N, 2009, Interact Cardiovasc Thorac Surg, V8, P558, DOI 10.1510/icvts.2008.196485
   Young PY, 2014, SURG CLIN N AM, V94, P1245, DOI 10.1016/j.suc.2014.08.008
NR 44
TC 9
Z9 14
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1547-4127
J9 THORAC SURG CLIN
JI Thorac. Surg. Clin.
PD MAY
PY 2017
VL 27
IS 2
BP 73
EP +
DI 10.1016/j.thorsurg.2017.01.001
PG 15
WC Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System; Surgery
GA ET6QE
UT WOS:000400415700002
PM 28363376
DA 2026-07-24
ER

PT J
AU Khan, MAA
   Chipp, E
   Hardwicke, J
   Srinivasan, K
   Shaw, S
   Rayatt, S
AF Khan, Muhammad Adil Abbas
   Chipp, Elizabeth
   Hardwicke, Joseph
   Srinivasan, Karthik
   Shaw, Simon
   Rayatt, Sukh
TI The use of Dermal Regeneration Template (Integra®) for reconstruction of
   a large full-thickness scalp and calvarial defect with exposed dura
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Scalp reconstruction; Skin substitute; Integra (R); Dura;
   Vacuum-Assisted Closure
ID ARTIFICIAL DERMIS
AB The reconstruction of large full-thickness scalp defects remains a challenge, particularly when dura is exposed. Various reconstructive methods have been described in the past. Dermal Regeneration Templates (DRTs) are becoming increasingly popular in the management of acute wounds as well as the reconstruction of burn scars, oncological defects and various other complex reconstructive problems. We describe a case where Integra (R) was successfully used together with a Vacuum-Assisted Closure (VAC) dressing to reconstruct a full-thickness scalp defect with exposed dura. Surgical technique is discussed as well as problems encountered during the case and possible solutions. (C) 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Khan, Muhammad Adil Abbas; Chipp, Elizabeth; Hardwicke, Joseph; Srinivasan, Karthik; Rayatt, Sukh] Univ Hosp N Staffordshire, Dept Plast & Reconstruct Surg, Stoke On Trent ST4 6QG, Staffs, England.
   [Shaw, Simon] Univ Hosp N Staffordshire, Dept Neurosurg, Stoke On Trent ST4 6QG, Staffs, England.
C3 Keele University; Keele University
RP Chipp, E (通讯作者)，Univ Hosp N Staffordshire, Dept Plast & Reconstruct Surg, Newcastle Rd, Stoke On Trent ST4 6QG, Staffs, England.
EM elizabeth_chipp@hotmail.com
CR Gonyon DL Jr, 2003, ANN PLAS SURG, V50, P315, DOI 10.1097/01.SAP.0000046788.45508.A3
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Khashab Mostafa El, 2009, J Neurosurg Pediatr, V4, P523, DOI 10.3171/2009.7.PEDS09220
   Koenen W, 2008, DERMATOL SURG, V34, P357, DOI 10.1111/j.1524-4725.2007.34069.x
   Leedy Jason E, 2005, Plast Reconstr Surg, V116, p54e, DOI 10.1097/01.prs.0000179188.25019.6c
   Moiemen NS, 2001, PLAST RECONSTR SURG, V108, P93, DOI 10.1097/00006534-200107000-00015
   Momoh AO, 2009, ANN PLAS SURG, V62, P656, DOI 10.1097/SAP.0b013e318180c913
   Tufaro AP, 2007, PLAST RECONSTR SURG, V120, P638, DOI 10.1097/01.prs.0000270298.68331.8a
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   Yeong EK, 2006, BURNS, V32, P375, DOI 10.1016/j.burns.2005.08.015
NR 10
TC 42
Z9 46
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2010
VL 63
IS 12
BP 2168
EP 2171
DI 10.1016/j.bjps.2010.03.017
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 683HE
UT WOS:000284463500056
PM 20335087
DA 2026-07-24
ER

PT J
AU Wollina, U
   Langner, D
   Heinig, B
   Schönlebe, J
   Nowak, A
AF Wollina, Uwe
   Langner, Dana
   Heinig, Birgit
   Schoenlebe, Jacqueline
   Nowak, Andreas
TI Complicated Skin and Skin Structure Infection After Erysipelas: Urgent
   Need for Antibiosis and Surgery
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE erysipelas; complicated skin and skin structure infection; panniculitis;
   vacuum-assisted closure therapy; surgery
ID SOFT-TISSUE INFECTIONS; RISK-FACTORS; CELLULITIS
AB Erysipelas are common soft tissue infections responding to first-line antibiosis. Because of factors of related to responsible bacteria and host, complications can occur that need extensive surgery in addition to intensified drug therapy. We report on a 65-year-old woman with leg ulcer who developed an absceding and necrotizing panniculitis of the affected leg complicating erysipelas. Escherichia coli and Pseudomonas aeruginosa were identified. Debridement and surgical removal of inflamed subcutaneous adipose tissue was decisive to interrupt the process. Wound bed preparation was realized by vacuum-assisted closure. Final wound closure was done by split-skin mesh graft. Complicated skin and skin structure infections need a combined approach of intensified antibiosis and surgery to save life.
C1 [Wollina, Uwe; Langner, Dana; Heinig, Birgit; Schoenlebe, Jacqueline; Nowak, Andreas] Acad Teaching Hosp Dresden Friedrichstadt, Dresden, Germany.
C3 Technische Universitat Dresden; Municipal Hospital Dresden
RP Wollina, U (通讯作者)，Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, Friedrichstr 41, D-01067 Dresden, Germany.
EM wollina-uw@khdf.de
RI ; Wollina, Uwe/AAJ-9644-2020
OI Nowak, Aneas/0000-0003-4105-4358; Wollina, Uwe/0000-0001-5933-2913
CR Bläckberg A, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1134-2
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   Gunderson CG, 2012, J INFECTION, V64, P148, DOI 10.1016/j.jinf.2011.11.004
   Krasagakis K, 2011, CLIN EXP DERMATOL, V36, P351, DOI 10.1111/j.1365-2230.2010.03978.x
   Lamb L, 2013, J ROY ARMY MED CORPS, V159, P215, DOI 10.1136/jramc-2013-000134
   Mortazavi M, 2013, INT J DERMATOL, V52, P279, DOI 10.1111/j.1365-4632.2012.05619.x
   Picard D, 2013, BRIT J DERMATOL, V168, P859, DOI 10.1111/bjd.12148
   Raya-Cruz M, 2014, ENFERM INFEC MICR CL, V32, P152, DOI 10.1016/j.eimc.2013.03.004
   Smolle J, 2000, HAUTARZT, V51, P14, DOI 10.1007/s001050050004
   Sunderkötter C, 2015, J DTSCH DERMATOL GES, V13, P501, DOI [10.1111/ddg.12721_suppl, 10.1111/ddg.12721]
   Unger L, 2013, INTERNIST, V54, P1314, DOI 10.1007/s00108-013-3341-5
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   Wollina U., 2012, EXPERT REV DERMATOL, V7, P419
NR 14
TC 2
Z9 5
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2016
VL 15
IS 1
BP 68
EP 70
DI 10.1177/1534734616628372
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DF9QY
UT WOS:000371697400012
PM 26933116
DA 2026-07-24
ER

PT J
AU Hoppe, IC
   Granick, MS
AF Hoppe, Ian C.
   Granick, Mark S.
TI Debridement of Chronic Wounds A Qualitative Systematic Review of
   Randomized Controlled Trials
SO CLINICS IN PLASTIC SURGERY
LA English
DT Review
DE Debridement; Wound healing; Chronic wounds
ID VACUUM-ASSISTED CLOSURE; LARVAL THERAPY; SURGICAL DEBRIDEMENT; LEG
   ULCERS; VENUS II; DRESSINGS; OUTCOMES
AB This article reviews the current evidence available regarding wound debridement of chronic wounds and collates data from existing randomized controlled trials.
C1 [Hoppe, Ian C.; Granick, Mark S.] New Jersey Med Sch UMDNJ, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Granick, MS (通讯作者)，New Jersey Med Sch UMDNJ, Div Plast Surg, 140 Bergen St,E1620, Newark, NJ 07103 USA.
EM mgranickmd@umdnj.edu
RI ; Hoppe, Ian/AAE-7361-2022
OI Granick, Mark/0000-0001-6507-1633; 
CR [Anonymous], OSTOMY WOUND MANAGE
   [Anonymous], OSTOMY WOUND MANAGE
   [Anonymous], SURG WOUND HEALING M
   [Anonymous], J WOUND CARE
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NR 41
TC 19
Z9 22
U1 0
U2 31
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD JUL
PY 2012
VL 39
IS 3
BP 221
EP +
DI 10.1016/j.cps.2012.04.001
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 980CN
UT WOS:000306871300002
PM 22732371
DA 2026-07-24
ER

PT J
AU Owen, LJ
   Hotston-Moore, A
   Holt, PE
AF Owen, L. J.
   Hotston-Moore, A.
   Holt, P. E.
TI Vacuum-assisted wound closure following urine-induced skin and thigh
   muscle necrosis in a cat
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Vacuum-assisted closure; wound; cat; urethral rupture; urine necrosis
ID URETHRAL RUPTURE; NEGATIVE-PRESSURE; THERAPY; MANAGEMENT; TRIAL
AB Vacuum-assisted closure (VAC) is a relatively new technique for wound management in dogs and cats. It was successfully used in this cat to treat severe urine-induced skin and thigh muscle necrosis, resulting from a traumatic urethral rupture. No complications were encountered with application of the VAC technique and production of a healthy granulation bed, suitable for wound reconstruction, was achieved after only five days of VAC treatment. The marked wound contraction (40.3%) obtained after eight days of treatment, was sufficient to allow closure of the defect using a simple, rotational subdermal plexus flap. This was a safe, effective and efficient treatment for a challenging wound in a difficult anatomical location.
C1 [Owen, L. J.; Hotston-Moore, A.; Holt, P. E.] Univ Bristol, Div Compan Anim Sci, Dept Vet Clin Sci, Bristol, Avon, England.
C3 University of Bristol
RP Owen, LJ (通讯作者)，Univ Cambridge, Dept Vet Med, Madingley Rd, Cambridge CB3 0ES, England.
EM lo247@cam.ac.uk
OI Hotston Moore, Alasdair/0000-0001-5404-7283
CR Anderson RB, 2006, J AM ANIM HOSP ASSOC, V42, P136, DOI 10.5326/0420136
   [Anonymous], OSTOMY WOUND MANAG S
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baines SJ, 2001, VET SURG, V30, P107, DOI 10.1053/jvet.2001.20327
   Ben-Amotz R, 2007, VET SURG, V36, P684, DOI 10.1111/j.1532-950X.2007.00321.x
   Bohling MW, 2004, VET SURG, V33, P579, DOI 10.1111/j.1532-950X.2004.04081.x
   Corgozinho KB, 2007, J FELINE MED SURG, V9, P481, DOI 10.1016/j.jfms.2007.09.002
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Guille AE, 2007, JAVMA-J AM VET MED A, V230, P1669, DOI 10.2460/javma.230.11.1669
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   Joseph E, 2000, WOUNDS, V12, P60
   Meige F, 2008, VET COMP ORTHOPAED, V21, P76, DOI 10.1160/VCOT-07-01-0010
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Nieddu A, 2007, VETERINARIA, V21, P57
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   WAKE MC, 1994, CELL TRANSPLANT, V3, P339, DOI 10.1177/096368979400300411
NR 19
TC 35
Z9 39
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2009
VL 22
IS 5
BP 417
EP 421
DI 10.3415/VCOT-08-12-0123
PG 5
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA 507TX
UT WOS:000270879100013
PM 19750293
DA 2026-07-24
ER

PT J
AU Scheufler, O
   Peek, A
   Kania, NM
   Exner, K
AF Scheufler, O
   Peek, A
   Kania, NM
   Exner, K
TI Problem-adapted application of vacuum occlusion dressings: case report
   and clinical experience
SO EUROPEAN JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted closure (VAC); wound conditioning; split skin graft
ID NEGATIVE-PRESSURE; ASSISTED CLOSURE; WOUND CONTROL
AB Vacuum-assisted closure (VAC), a technique using subatmospheric pressure dressings, has been widely used for treatment of various chronic and complicated wounds. In addition to the advantages of an occlusive dressing therapy, the VAC therapy has proved effective in evacuating wound fluid, increasing tissue oxygen tension, decreasing bacterial contamination, and stimulating granulation tissue formation. This leads to more rapid reepithelialization of wounds compared to conventional dressings. A two-phase VAC technique to provide enhanced coverage of an ischemic ulcer of the lower leg in a diabetic patient is presented. The refined VAC therapy scheme is described in detail and the results in a further 19 patients with complicated wounds of the lower leg and feet are reported.
C1 Univ Frankfurt, Acad Teaching Hosp, Markus Hosp, Dept Plast Reconstruct & Handsurg,Sch Med, D-60431 Frankfurt, Germany.
C3 Goethe University Frankfurt
RP Scheufler, O (通讯作者)，Univ Frankfurt, Acad Teaching Hosp, Markus Hosp, Dept Plast Reconstruct & Handsurg,Sch Med, Wilhelm Epstein Str 2, D-60431 Frankfurt, Germany.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bauer P, 1998, Handchir Mikrochir Plast Chir, V30, P20
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 7
TC 2
Z9 6
U1 0
U2 3
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0930-343X
J9 EUR J PLAST SURG
JI Eur. J. Plast. Surg.
PD OCT
PY 2000
VL 23
IS 7
BP 386
EP 390
DI 10.1007/s002380000189
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 368YT
UT WOS:000090145600011
DA 2026-07-24
ER

PT J
AU Negosanti, L
   Sgarzani, R
   Nejad, P
   Pinto, V
   Tavaniello, B
   Palo, S
   Oranges, CM
   Fabbri, E
   Michelina, VV
   Zannetti, G
   Morselli, PG
   Cipriani, R
AF Negosanti, Luca
   Sgarzani, Rossella
   Nejad, Parissa
   Pinto, Valentina
   Tavaniello, Beatrice
   Palo, Stefano
   Oranges, Carlo Maria
   Fabbri, Erich
   Michelina, Veronica Vietti
   Zannetti, Guido
   Morselli, Paolo Giovanni
   Cipriani, Riccardo
TI VAC® therapy for wound management in patients with contraindications to
   surgical treatment
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE complex wound; topical negative pressure; VAC
ID VACUUM-ASSISTED CLOSURE; PRESSURE
AB The treatment of complex wounds often requires multiple surgical debridement and eventually reconstruction with skin grafts or flaps, under local or general anesthesia. When the patient's general conditions contraindicate surgical procedures, topical negative pressure with Vacuum Assisted Closure (VAC (R)) device can achieve wound healing with reduction of healing time and simpler management. We treated with VAC (R) device four patients with complex wounds and important contraindications to surgery. In all the patients, we used VAC (R) device with common protocol of topical negative pressure. The healing was obtained in a period variable between 18 and 40 days; the results were satisfactory in three cases, one patient developed an aesthetically unpleasant scar. We present our experience to propose VAC (R) when surgical procedures are contraindicated.
C1 [Negosanti, Luca; Sgarzani, Rossella; Nejad, Parissa; Pinto, Valentina; Tavaniello, Beatrice; Palo, Stefano; Oranges, Carlo Maria; Fabbri, Erich; Michelina, Veronica Vietti; Zannetti, Guido; Morselli, Paolo Giovanni; Cipriani, Riccardo] St Orsola Marcello Malpighi Hosp, Dept Plast Surg, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna
RP Negosanti, L (通讯作者)，St Orsola Marcello Malpighi Hosp, Dept Plast Surg, Via Massarenti 9, I-40138 Bologna, Italy.
EM luca.negosanti81@gmail.com
RI Oranges, Carlo M/ABI-2156-2020; Negosanti, Luca/AAF-1605-2020; Sgarzani,
   Rossella/M-7495-2018
OI Oranges, Carlo M/0000-0003-1735-5329; Negosanti,
   Luca/0000-0002-8110-3604; FABBRI, ERICH/0000-0002-3808-3185; Sgarzani,
   Rossella/0000-0002-5543-8013
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 14
TC 6
Z9 6
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAY-JUN
PY 2012
VL 25
IS 3
SI SI
BP 277
EP 280
DI 10.1111/j.1529-8019.2012.01451.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 993TH
UT WOS:000307882000010
PM 22913447
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cove, ME
   Spelman, DW
   MacLaren, G
AF Cove, Matthew E.
   Spelman, Denis W.
   MacLaren, Graeme
TI Infectious Complications of Cardiac Surgery: A Clinical Review
SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
LA English
DT Review
DE infection (postoperative); intensive care; postoperative care; surgery;
   complications; cardiac surgical procedures; thoracic surgery
ID VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE INSULIN THERAPY;
   SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; STERNAL
   WOUND-INFECTION; CHLORHEXIDINE-IMPREGNATED SPONGES; CATHETER-RELATED
   INFECTIONS; CENTRAL VENOUS CATHETERS; BLOOD-STREAM INFECTIONS;
   CRITICALLY-ILL PATIENTS
C1 [Cove, Matthew E.] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15261 USA.
   [Spelman, Denis W.] Alfred Hosp, Dept Infect Dis & Microbiol, Melbourne, Vic, Australia.
   [MacLaren, Graeme] Royal Childrens Hosp, Paediat Intens Care Unit, Melbourne, Vic, Australia.
   [MacLaren, Graeme] Natl Univ Hlth Syst, Dept Cardiac Thorac & Vasc Surg, Singapore, Singapore.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Florey Institute of Neuroscience & Mental Health; Howard
   Florey Institute Affiliates; Royal Children's Hospital Melbourne;
   National University of Singapore
RP Cove, ME (通讯作者)，Univ Pittsburgh, Dept Crit Care Med, 3550 Terrace St, Pittsburgh, PA 15261 USA.
EM cove.matthew@gmail.com
RI MacLaren, Graeme/C-6836-2011; Cove, Matthew/AAP-5051-2020
OI Cove, Matthew/0000-0003-3805-4680
FU NIH [HL07820]; National Heart Lung and Blood Institute [T32HL007820]
   Funding Source: NIH RePORTER
FX M.E.C. acknowledges support from NIH grant HL07820. The views expressed
   in this article do not represent the views of or endorsement by the
   National Institutes of Health.
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NR 97
TC 49
Z9 56
U1 0
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1053-0770
EI 1532-8422
J9 J CARDIOTHOR VASC AN
JI J. Cardiothorac. Vasc. Anesth.
PD DEC
PY 2012
VL 26
IS 6
BP 1094
EP 1100
DI 10.1053/j.jvca.2012.04.021
PG 7
WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System;
   Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System
GA 036DN
UT WOS:000311006700023
PM 22765993
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ennker, IC
   Bär, AK
   Florath, I
   Ennker, J
   Vogt, PM
AF Ennker, I. C.
   Baer, A. K.
   Florath, I.
   Ennker, J.
   Vogt, P. M.
TI In Search of a Standardized Treatment for Poststernotomy Mediastinitis
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE sternotomy; mediastinitis; vacuum therapy; sternal stabilization;
   therapeutic algorithm
ID VACUUM-ASSISTED CLOSURE; WOUND INFECTIONS; STERNOTOMY; TRANSPOSITION;
   EXPERIENCE; MANAGEMENT; ARTERY; FLAP
AB Poststernotomy mediastinitis following median sternotomy procedures such as open heart surgery is a rare complication which nevertheless has a mortality rate of up to 50%. Several treatment options are currently available; however, none of them are standardized. Based on the experience gained from open heart surgery performed at the MediClin Heart Institute Lahr/Baden, a therapeutic algorithm was developed. The treatment steps consist of repeated radical surgical debridement, sternal restabilization, vacuum-assisted closure therapy (VAC) as well as a surgical reconstruction via M. pectoralis plasty (MPP). This approach had a 30-day mortality of 0% and a hospital mortality of 10.4%. The approach proved to be safe and advantageous for specific patient groups operated on at the MediClin Heart Institute Lahr/Baden.
C1 [Ennker, I. C.; Baer, A. K.; Florath, I.; Ennker, J.] MediClin Heart Inst Lahr Baden, D-77933 Lahr, Germany.
   [Ennker, I. C.; Vogt, P. M.] Hannover Med Sch, Clin Plast Chiroplast & Restorat Surg, D-3000 Hannover, Germany.
C3 Hannover Medical School
RP Bär, AK (通讯作者)，MediClin Heart Inst Lahr Baden, Hohbergweg 2, D-77933 Lahr, Germany.
EM antonia.baer@mediclin.de
RI Vogt, Peter/AAL-1332-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 20
TC 15
Z9 17
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD FEB
PY 2011
VL 59
IS 1
BP 15
EP 20
DI 10.1055/s-0030-1250335
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 707TE
UT WOS:000286310200003
PM 21243566
DA 2026-07-24
ER

PT J
AU Ollat, D
   Bouchard, A
   Tramond, B
   Nuzzaci, F
   Barbier, O
   Versier, G
AF Ollat, Didier
   Bouchard, A.
   Tramond, B.
   Nuzzaci, F.
   Barbier, O.
   Versier, G.
TI Vacuum-assisted closure: a low-cost negative pressure system for wound
   management
SO EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
LA English
DT Article
DE Vacuum-assisted closure; Negative pressure therapy; Wound; Humanitarian
   surgery
ID EXPERIENCE; THERAPY
AB Negative pressure dressings are helpful for humanitarian surgery for healing infected and late-treated large wounds and also wounds with large loss of skin. However, specific commercial device has high costs that are prohibitive for precarious surgery with limited funds and an austere environment. Our idea is to make a negative pressure dressing using only low-cost and non-specific surgical devices. We describe a technical device of negative pressure in which only low-cost disposable medical equipments were used. The vacuum comes from a surgical room electric pump or from a single-use suction canister. Our successful experience suggests that this low-cost alternative method of negative pressure dressing can be safely used in countries with limited health care systems.
C1 [Ollat, Didier; Bouchard, A.; Barbier, O.; Versier, G.] Hop Instruct Armees Begin, Serv Chirurg Orthoped & Traumatol, F-94160 St Mande, France.
   [Tramond, B.] Hop Instruct Armees Laveran, Serv Chirurg Orthoped & Traumatol, F-13000 Marseille, France.
   [Nuzzaci, F.] Hop Mil Instruct, Serv Chirurg Orthoped & Traumatol, Ndjamena, Chad.
RP Ollat, D (通讯作者)，Hop Instruct Armees Begin, Serv Chirurg Orthoped & Traumatol, 69 Paris, F-94160 St Mande, France.
EM didier.ollat@neuf.fr
RI Barbier, Olivier/Z-2116-2019
CR Akhtar S, 2006, ANN PLAS SURG, V56, P700, DOI 10.1097/01.sap.0000214870.57943.f7
   Andreassen GS, 2006, ACTA ORTHOP, V77, P820, DOI 10.1080/17453670610013051
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NR 8
TC 2
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1633-8065
J9 EUR J ORTHOP SURG TR
JI Eur. J. Orthop. Surg. Traumatol.
PD OCT
PY 2009
VL 19
IS 7
BP 505
EP 509
DI 10.1007/s00590-009-0458-2
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 495GW
UT WOS:000269879800012
DA 2026-07-24
ER

PT J
AU Tan, L
   Hou, ZY
   Gao, YZ
AF Tan, Lei
   Hou, Zhongyu
   Gao, Yanzhi
TI Efficacy of combined treatment with vacuum sealing drainage and
   recombinant human epidermal growth factor for refractory wounds in the
   extremities and its effect on serum levels of IL-6, TNF-α and IL-2
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; recombinant human epidermal growth factor; hand
   and foot surgery; refractory wound; inflammatory factor
ID DIABETIC FOOT ULCERS; THERAPY; REGENERATION; ENHANCE; QUALITY; RHEGF
AB The objective of this study was to investigate the efficacy of combined treatment with vacuum sealing drainage (VSD) and recombinant human epidermal growth factor (rhEGF) for refractory wounds in the extremities, and its effect on serum levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and IL-2. Ninety-eight patients with refractory wounds in the extremities were recruited and randomly divided into the combined treatment group (underwent VSD and rhEGF treatment) and control group (underwent VSD only) with 49 cases each. Formation of granulation tissue on the wound surface was assessed and scored. The wound healing rate was calculated after 1 week of treatment, and the time of complete healing was recorded. Serum levels of IL-6, IL-2, and TNF-alpha were measured using enzyme-linked immunosorbent assay. After 1 week of treatment, granulation tissue formation on wound surfaces was significantly improved (p<0.05) compared with that before treatment in both groups. Moreover, granulation tissue formation on wound surfaces was superior in the combined treatment group than in the control group (p<0.05). The wound healing rate was 63.50 +/- 4.75% in the combined treatment group and 31.79 +/- 3.52% in the control group, and the difference was statistically significant (p<0.05). The time of complete healing was 15.11 +/- 2.24 days in the combined treatment group and 19.63 +/- 2.76 days in the control group, and the difference was statistically significant (p<0.05). The serum levels of IL-6, IL-2, and TNF-alpha, in the two groups were significantly lower than those before treatment (p<0.05). Moreover, the levels in the combined treatment group were significantly lower than those in the control group (p<0.05). In conclusion, combined treatment with VSD and rhEGF reduced inflammation and shortened the time of complete healing of refractory wounds in the extremities. Measurement of the levels of related inflammatory factors provided a reference for the prognosis of refractory wounds.
C1 [Tan, Lei] Zhangqiu Hosp Chinese Med, Traumatol Ward 1, Zhangqiu 250200, Shandong, Peoples R China.
   [Hou, Zhongyu] Laiwu Iron & Steel Grp Co Ltd Hosp, Traumatol Ward 2, Laiwu 271126, Shandong, Peoples R China.
   [Gao, Yanzhi] Cent Hosp Shengli Oilfield, Dept Emergency, 31 Jinan Rd, Dongying 257034, Shandong, Peoples R China.
RP Gao, YZ (通讯作者)，Cent Hosp Shengli Oilfield, Dept Emergency, 31 Jinan Rd, Dongying 257034, Shandong, Peoples R China.
EM gyp7pv@163.com
RI hou, zhong/KZT-9649-2024
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NR 22
TC 12
Z9 16
U1 0
U2 9
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2018
VL 15
IS 1
BP 288
EP 294
DI 10.3892/emt.2017.5360
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FV0WL
UT WOS:000424281600038
PM 29250151
DA 2026-07-24
ER

PT J
AU Zhang, L
   Zhao, Y
   Lu, Y
   He, PP
   Zhang, P
   Lv, ZH
   Shen, YX
AF Zhang, Lei
   Zhao, Yao
   Lu, Yan
   He, Pingping
   Zhang, Peng
   Lv, Zhanhui
   Shen, Yixin
TI Effects of vacuum sealing drainage to improve the therapeutic effect in
   patients with orthopedic trauma and to reduce post-operative infection
   and lower-limb deep venous thrombosis
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE vacuum sealing drainage; orthopedic trauma; postoperative infection;
   lower-limb deep venous thrombosis
ID PRESSURE WOUND THERAPY
AB The present study investigated the effects of vacuum sealing drainage (VSD) to improve the therapeutic efficacy in patients with orthopedic trauma (OT) and reduce post-operative infection and lower-limb deep venous thrombosis (DVT) through a retrospective analysis. A total of 76 patients with OT treated at our hospital were selected for observation. The patients were divided into the control group (CG; n=37) and the experimental group (EG; n=39) according to the treatment administered. For patients in the CG, routine dressing changes were applied. Patients in the EG underwent VSD treatment. The dressing change frequency, time between the first and second operation, hospital stay, treatment efficacy, wound healing time, interleukin-6 (IL-6) serum level, tumor necrosis factor-alpha (TNF-alpha) serum level, incidence of post-operative infection and incidence of lower-limb DVT were compared between the two groups. The dressing change frequency in the EG was less than that in the CG. The time between the first and second operation and hospital stay were shorter in the EG than in the CG (P < 0.05). The total effective rate in the EG was 97.44%, which was higher than that in the CG (78.38%; P < 0.05). The wound healing time in the EG was 1.72 +/- 0.73 weeks and shorter than that in the CG (2.23 +/- 0.85 weeks; P < 0.05). With the progression of treatment, the serum IL-6 and TNF-alpha levels decreased in the two groups, but the levels in the EG were lower than those in the CG (P < 0.05). The incidence of post-operative infection and lower-limb venous thrombosis in the EG were 7.69 and 0.00%, respectively, and lower than those in the CG (27.03 and 13.01%, respectively; P < 0.05). In the treatment of OT, VSD may reduce the dressing change frequency, shorten the operation time and hospital stay, accelerate wound healing and reduce post-operative infection and lower-limb DVT. Thus, the VSD treatment method is worthy of promotion and implementation in clinic.
C1 [Zhang, Lei; Zhang, Peng; Shen, Yixin] Soochow Univ, Dept Orthopaed, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215006, Jiangsu, Peoples R China.
   [Zhang, Lei; Lu, Yan; Lv, Zhanhui] Binzhou Med Univ, Dept Orthopaed, Binzhou Cent Hosp, Binzhou 251700, Shandong, Peoples R China.
   [Zhao, Yao] Shandong Univ, Dept Orthoped, Shandong Prov ENT Hosp, Jinan 250000, Shandong, Peoples R China.
   [He, Pingping] Binzhou Med Univ, Dept Clin Pharm, Binzhou Cent Hosp, Binzhou 251700, Shandong, Peoples R China.
C3 Soochow University - China; Shandong Medical & Pharmaceutical
   University; Shandong University; Shandong Medical & Pharmaceutical
   University
RP Shen, YX (通讯作者)，Soochow Univ, Dept Orthopaed, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215006, Jiangsu, Peoples R China.
EM yyyishee@163.com
OI Zhao, Yao/0009-0008-2468-9910
CR Angspatt A, 2017, ARCH PLAST SURG-APS, V44, P575
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NR 25
TC 13
Z9 20
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD SEP
PY 2020
VL 20
IS 3
BP 2305
EP 2310
DI 10.3892/etm.2020.8941
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NG2VU
UT WOS:000563844300057
PM 32765709
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, XC
   Shi, YL
   Yang, Y
AF Zhang, Xichun
   Shi, Yingli
   Yang, Yan
TI The influence of the IKAP nursing model on wound healing following
   vacuum sealing drainage in acute infective endocarditis: a retrospective
   study
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE acute infectiveEndocarditis; IKAP nursing model; retrospective study;
   vacuum sealing drainage; wound healing
ID CARE
AB Background Acute infective endocarditis (IE) presents clinical challenges due to its complex pathophysiology and potential for severe complications. Vacuum sealing drainage (VSD) is an essential treatment approach, and nursing care plays a pivotal role in patient outcomes. The Innovative Knowledge-Attitude-Practice (IKAP) nursing model is a patient-centered approach emphasizing health education, behavioral engagement, and self-management support. This study aimed to investigate the association between the IKAP nursing model and wound healing following VSD in patients with acute IE.Methods A retrospective analysis of 240 patients with acute IE undergoing VSD was conducted from January 2023 to December 2023. Patients were categorized into routine nursing (n = 117) and IKAP nursing (n = 123) groups based on admission period. Baseline characteristics, VSD details, laboratory results, medication usage, hospitalization details, wound size reduction, pain scores, and postoperative complications were compared. Multivariate logistic regression was performed to adjust for potential confounders.Results Baseline disease-related characteristics, VSD characteristics, and several laboratory parameters did not significantly differ between the two nursing groups. The IKAP nursing group demonstrated a lower white blood cell count (9.94 +/- 2.29 vs. 10.57 +/- 2.14 & times; 109/L, P = 0.029), greater wound size reduction at week 4 (3.52 +/- 0.82 vs. 3.77 +/- 0.95 cm2, P = 0.034), lower pain scores at week 4 (5.45 +/- 1.93 vs. 5.98 +/- 1.85, P = 0.031), and reduced incidence of wound infection (0.81% vs. 6.84%, adjusted OR = 0.11, 95% CI: 0.01-0.89, P = 0.034) and other adverse events (1.63% vs. 8.55%, adjusted OR = 0.18, 95% CI: 0.04-0.84, P = 0.031) following VSD. However, these differences were not sustained at week 8.Conclusion The findings suggest a potential association between the IKAP nursing model and improved wound healing, pain management, and reduced postoperative complications in patients undergoing VSD for acute IE, particularly during the early recovery phase. Given the retrospective nature and observed attenuation of effects at week 8, prospective studies are warranted to confirm these findings.
C1 [Zhang, Xichun; Yang, Yan] NanYang First Peoples Hosp, Dept Cardiovasc Med 1, Nanyang, Henan, Peoples R China.
   [Shi, Yingli] NanYang First Peoples Hosp, Dept Cardiac & Large Vasc Surg, Nanyang, Henan, Peoples R China.
RP Zhang, XC (通讯作者)，NanYang First Peoples Hosp, Dept Cardiovasc Med 1, Nanyang, Henan, Peoples R China.
EM zxc15503771143@163.com
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 11
PY 2026
VL 13
AR 1671655
DI 10.3389/fcvm.2026.1671655
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FM4UM
UT WOS:001722255700001
PM 41890872
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, RF
   Hua, HT
   Wang, XW
   Guo, ZR
   Zhong, WL
AF Yang, Ruifang
   Hua, Haotian
   Wang, Xinwei
   Guo, Zairan
   Zhong, Wenlong
TI Vacuum sealing drainage combined with eggshell-like debridement
   antibiotic-loaded calcium sulphate for calcaneal osteomyelitis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Eggshell-like debridement; Vacuum sealing drainage; Antibiotic-loaded
   calcium sulphate; Calcaneal osteomyelitis
AB Background To compare the clinical efficacy of vacuum sealing drainage, eggshell-like debridement combined with antibiotic calcium sulphate implantation and conventional debridement combined with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis. Methods Sixty-six patients with calcaneal osteomyelitis who were treated in our department between January 2017 and August 2021 were included in this study. Thirty-one patients underwent VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation. Thirty-five patients underwent conventional debridement combined with antibiotic calcium sulphate implantation. The inflammatory markers, operation time, wound healing time, hospital stay, full weight bearing time after operation, recurrence rate of infection, complications, and American Orthopedic Foot and Ankle Society (AOFAS) scores were compared between the two groups. Results The operation time and full weight bearing time after operation of observation group were longer than that of control group. Compared with preoperative results, WBC, ESR, CRP and PCT in both groups were significantly decreased at 14 days after operation, and there was no statistical significance between the two groups. The wound healing time and hospital stay in the observation group were shorter than those in the control group (P < 0.05). There were four patients with aseptic exudation in the observation group and ten patients with aseptic exudation in the control group, and the wounds healed well after multiple dressing changes. Seven patients in the observation group underwent secondary bone grafting due to bone defects, and four patients in the control group received secondary bone grafting due to bone defects. In the observation group, three patients received debridement combined with antibiotic calcium sulphate implantation again due to recurrent infection, compared with seven patients in the control group. One year after operation, the observation group had a better AOFAS scores than the control group, especially in terms of foot function (P < 0.05). Conclusion Compared with conventional debridement and antibiotic calcium sulphate implantation, VSD and eggshell-like debridement combined with antibiotic calcium sulphate implantation in the treatment of calcaneal osteomyelitis can shorten the wound healing and hospital stay of patients, reduce postoperative aseptic exudation complications and infection recurrence rate, and better preserve the foot function, which is a simple and effective method.
C1 [Yang, Ruifang; Wang, Xinwei; Guo, Zairan; Zhong, Wenlong] Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Bone & Joint Infect, Luoyang, Peoples R China.
   [Yang, Ruifang] Henan Univ Tradit Chinese Med, Degree & Grad Educ Luoyang Work Dept, Luoyang, Peoples R China.
   [Hua, Haotian] Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Zhejiang Chinese
   Medical University
RP Wang, XW (通讯作者)，Luoyang Orthoped Traumatol Hosp Henan Prov, Dept Bone & Joint Infect, Luoyang, Peoples R China.
EM lywxw188@163.com
FU We would like to thank all the patients who participated in the study
   for their cooperation.
FX We would like to thank all the patients who participated in the study
   for their cooperation.
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NR 21
TC 6
Z9 6
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 24
PY 2023
VL 18
IS 1
AR 796
DI 10.1186/s13018-023-04259-6
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA W1IF2
UT WOS:001089226700005
PM 37875933
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tiang, T
   Behrenbruch, C
   Noori, J
   Lam, D
   Bhamidipaty, M
   Johnston, M
   Woods, R
   D'Souza, B
AF Tiang, Thomas
   Behrenbruch, Corina
   Noori, Jawed
   Lam, David
   Bhamidipaty, Madhu
   Johnston, Michael
   Woods, Rodney
   D'Souza, Basil
TI Prophylactic negative pressure wound therapy to improve wound healing
   rates following ileostomy closure: a randomized controlled trial
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE ileostomy reversal; negative pressure wound therapy; stoma closure
ID SURGICAL SITE INFECTION; STOMA REVERSAL; PURSESTRING CLOSURE;
   ANASTOMOTIC LEAKAGE; METAANALYSIS; CANCER
AB BackgroundReversal of ileostomy is associated with morbidity including wound infection and prolonged wound healing. Negative pressure wound therapy (NPWT) has been shown to reduce time to wound healing by secondary intention. The aim of this study was to determine whether NPWT improved wound healing rates, compared with simple wound dressings, in patients undergoing reversal of ileostomy where the skin wound is closed with a purse-string suture.MethodsThis was a dual-centre, open-label, randomized controlled trial with two parallel intervention arms. Patients undergoing elective loop ileostomy reversal were randomized 1:1 to receive NPWT or simple wound dressings. The primary endpoint of the study was assessment of complete wound healing at day 42 post reversal of ileostomy and the secondary endpoints were patient-reported wound cosmesis using a visual analogue scale and rates of surgical site infection (SSI).ResultsThe study was conducted from June 2018 to December 2021. The trial was approved by the local ethics committee. We enrolled 40 patients, 20 in each arm. One patient in each arm was lost to follow up. Nine patients (9/19, 47.36%) in the simple dressing group had wound healing vs. 13 patients (13/19, 68.42%) in the NPWT group (P = 0.188). There was no significant difference in patient- reported wound cosmesis or SSI.ConclusionThere was no difference in wound healing rates when comparing NPWT to simple wound dressings at early and late time points post reversal of ileostomy, where the skin wound was closed with a purse-string suture.
   Reversal of ileostomy is associated with morbidity including wound infection and prolonged wound healing. Negative pressure wound therapy (NPWT) has been shown to reduce time to wound healing by secondary intention. The aim of this study was to determine whether NPWT improves wound healing compared with simple wound dressings in patients following ileostomy closure. We found no significant difference in wound healing rates when comparing NPWT to simple wound dressings at early and late time points post reversal of stoma. image
C1 [Tiang, Thomas; Behrenbruch, Corina; Noori, Jawed; Lam, David; Bhamidipaty, Madhu; Johnston, Michael; Woods, Rodney; D'Souza, Basil] St Vincents Hosp Melbourne, Dept Colorectal Surg, Fitzroy, Vic, Australia.
   [Behrenbruch, Corina] Univ Melbourne, Dept Clin Educ, Melbourne, Vic, Australia.
   [Behrenbruch, Corina] St Vincents Hosp Melbourne, Dept Colorectal Surg, Level 2-41 Victoria Parade, Fitzroy, Vic 3065, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; University of
   Melbourne; St Vincent's Health; St Vincent's Hospital Melbourne
RP Behrenbruch, C (通讯作者)，St Vincents Hosp Melbourne, Dept Colorectal Surg, Level 2-41 Victoria Parade, Fitzroy, Vic 3065, Australia.
EM cori.behrenbruch@gmail.com
RI ; Bhamidipaty, Madhu/GPF-4906-2022
OI Noori, Jawed/0009-0001-0910-7803; 
FU Wounds Australia; University of Melbourne, as part of the Wiley - The
   University of Melbourne agreement via the Council of Australian
   University Librarians
FX Open access publishing facilitated by The University of Melbourne, as
   part of the Wiley - The University of Melbourne agreement via the
   Council of Australian University Librarians.
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   Uchino M, 2016, DIGEST SURG, V33, P449, DOI 10.1159/000446550
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NR 25
TC 10
Z9 10
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD SEP
PY 2024
VL 94
IS 9
BP 1627
EP 1633
DI 10.1111/ans.18941
EA MAR 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H2O3V
UT WOS:001189950300001
PM 38525845
OA hybrid
DA 2026-07-24
ER

PT J
AU Nherera, LM
   Trueman, P
   Schmoeckel, M
   Fatoye, FA
AF Nherera, Leo M.
   Trueman, Paul
   Schmoeckel, Michael
   Fatoye, Francis A.
TI Cost-effectiveness analysis of single use negative pressure wound
   therapy dressings (sNPWT) compared to standard of care in reducing
   surgical site complications (SSC) in patients undergoing coronary artery
   bypass grafting surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Single use negative pressure wound therapy; cost-effectiveness; Surgical
   site complications; CABG
ID METAANALYSIS; INFECTION
AB Background: There is a growing interest in using negative pressure wound therapy in closed surgical incision to prevent wound complications which continue to persist following surgery despite advances in infection measures.
   Objectives: To estimate the cost-effectiveness of single use negative pressure wound therapy (sNPWT) compared to standard of care in patients following coronary artery bypass grafting surgery (CABG) procedure to reduce surgical site complications (SSC) defined as dehiscence and sternotomy infections.
   Method: A decision analytic model was developed from the Germany Statutory Health Insurance payer's perspective over a 12-week time horizon. Baseline data on SSC, revision operations, length of stay, and readmissions were obtained from a prospective observational study of 2621 CABG patients in Germany. Effectiveness data for sNPWT was taken from a randomised open label trial conducted in Poland which randomised 80 patients to treatment with either sNPWT or standard care. Cost data (in Euros) were taken from the relevant diagnostic related groups and published literature.
   Results: The clinical study reported an increase in wounds that healed without complications 37/40 (92.5%) in the sNPWT compared to 30/40 (75%) patients in the SC group p = 0.03. The model estimated sNPWT resulted in 0.989 complications avoided compared to 0.952 and the estimated quality adjusted life years were 0.8904 and 0. 8593 per patient compared to standard care. The estimated mean cost per patient was (sic)19,986 for sNPWT compared to (sic)20,572 for SC resulting in cost-saving of (sic)586. The findings were robust to a range of sensitivity analyses.
   Conclusion: The sNPWT can be considered a cost saving intervention that reduces surgical site complications following CABG surgery compared to standard care. We however recommend that additional economic studies should be conducted as new evidence on the use of sNPWT in CABG patients becomes available to validate the results of this economic analysis.
C1 [Nherera, Leo M.; Trueman, Paul] Global Market Access, Smith & Nephew Adv Wound Management, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
   [Schmoeckel, Michael] Asklepios Klin St Georg Cardiac, Dept Heart Surg, Vasc & Diabet Ctr, Lohmuhlenstr 5, D-20099 Hamburg, Germany.
   [Fatoye, Francis A.] Manchester Metropolitan Univ, Dept Hlth Profess, Manchester, Lancs, England.
C3 Smith & Nephew; Manchester Metropolitan University
RP Nherera, LM (通讯作者)，Global Market Access, Smith & Nephew Adv Wound Management, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM leo.nherera@smith-nephew.com
RI ; Nherera, Leo/L-1978-2019
OI Fatoye, Francis/0000-0002-3502-3953; Nherera, Leo/0000-0003-1758-9504
CR Cristofolini M, 2012, INFECTION, V40, P397, DOI 10.1007/s15010-012-0275-0
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NR 22
TC 31
Z9 34
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD OCT 3
PY 2018
VL 13
AR 103
DI 10.1186/s13019-018-0786-6
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA GW0IT
UT WOS:000446547700004
PM 30285811
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cwalinski, J
   Hermann, J
   Banasiewicz, T
AF Cwalinski, Jaroslaw
   Hermann, Jacek
   Banasiewicz, Tomasz
TI Healing Peristomal Wounds Around Retracted Stomas with Negative-Pressure
   Wound Therapy: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE hydrofiber dressing; negative-pressure wound therapy; ostomy; peristomal
   infection; peristomal leak; retraction; wound care
ID COMPLICATIONS; MANAGEMENT; OSTOMY
AB One method for treating a retracted stoma is a vacuum dressing that cleans the wound and protects against intestinal leakage. This case series describes the use of an integrated, single-use negative-pressure wound therapy (NPWT) dressing to treat retracted stomas as an alternative to other noninvasive remedies. The report includes seven patients who were hospitalized in the authors' surgical department from 2019 to 2020. All patients developed severe peristomal infection that failed to respond to local treatment with proper ostomy appliances or specialist dressings. After cleaning each wound and removing necrotic lesions, the authors applied a single-use hydrofiber NPWT dressing to each patient. The dressing was changed every 2 to 5 days, depending on the effects of the therapy. The stoma orifice was covered with a bag with two-piece ostomy systems. The peristomal wound healed in all cases, and leakage was eliminated. The mean time of treatment was 14 days (range, 10-21 days), and the vacuum dressings were changed an average of four times (range, 3-7 times). None of the patients required a stoma translocation or other additional surgery. Three patients received systemic IV antibiotic therapy to treat general infection. Single-use NPWT dressings protect peristomal wounds from bowel leakage and do not hinder the application of stoma bags. This system, similar to standard NPWT devices, effectively protects infected stomas from retraction.
C1 [Cwalinski, Jaroslaw; Hermann, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Cwalinski, J (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Poznan, Poland.
RI Cwalinski, Jaroslaw/IAR-7448-2023
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NR 26
TC 2
Z9 3
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2023
VL 36
IS 8
BP 435
EP 440
DI 10.1097/ASW.0000000000000006
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA M9VZ3
UT WOS:001033630600011
PM 37471448
DA 2026-07-24
ER

PT J
AU Zhou, LR
   Li, C
   Guan, XH
   Xie, J
   Lin, WL
   Wu, BM
   Chen, Y
   Huang, JW
   Gong, LJ
AF Zhou, Linrong
   Li, Cui
   Guan, Xuehong
   Xie, Jing
   Lin, Wanli
   Wu, Bomeng
   Chen, Ying
   Huang, Jiawei
   Gong, Lanjuan
TI Study on the application of modified negative pressure wound therapy
   with instillation in cervical anastomotic leakage after oesophageal
   cancer surgery
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE negative-pressure wound therapy with instillation; oesophageal cancer;
   cervical anastomotic leakage; odour management; negative-pressure wound
   therapy
AB <bold>Aims:</bold> This study aims to explore the feasibility and safety of modified negative-pressure wound therapy with instillation (NPWTi) for the treatment of cervical anastomotic leakage (CAL) after oesophageal cancer surgery. <bold>Methods:</bold> A retrospective analysis was conducted on 17 patients who developed CAL after oesophageal cancer surgery and received modified NPWTi treatment at our hospital from 2021 to 2024. The primary outcome was the time to healing, defined as the number of days from the initiation of modified NPWTi to complete fistula closure. Secondary outcomes included wound odour improvement and patient comfort. <bold>Results:</bold> A total of 17 patient were collected, including 10 men and seven women, with an average age of 73.71 +/- 8.01 years. None received neoadjuvant therapy, and no patients had diabetes; preoperative albumin was 38.77 +/- 3.58 g/L. The occurrence of CAL was noted at 8.88 +/- 3.15 d (95% CI: 7.26 to 10.51 d) post-surgery. The modified treatment was commenced 0-12 d after CAL diagnosis, with the earliest case starting on the day of diagnosis. The mean duration of modified NPWTi was 10.88 +/- 6.54 d (95% CI: 7.52 to 14.25 d). For the primary outcome, the time from treatment initiation to complete healing was 15.00 +/- 7.26 d (95% CI: 11.27 to 18.73 d), with a minimum of five days. No mediastinal or pleural infections related to NPWTi occurred during the treatment. For the secondary outcomes, a significant improvement in wound odour was observed following the administration of the modified NPWTi (P<0.001), with an improvement rate of 100% (95% CI: 85-100%). During the treatment, the patients reported feeling comfortable and expressed overall satisfaction. <bold>Conclusion:</bold> Modified NPWTi demonstrated significant efficacy and convenience in treating CAL after oesophageal cancer surgery, benefiting both patients and healthcare providers with good safety profiles, thus warranting broader clinical application.
C1 [Zhou, Linrong; Li, Cui; Guan, Xuehong; Xie, Jing; Lin, Wanli; Wu, Bomeng; Chen, Ying; Huang, Jiawei; Gong, Lanjuan] Gaozhou Peoples Hosp, Dept Thorac Surg, Maoming, Guangdong, Peoples R China.
   [Zhou, Linrong; Li, Cui; Guan, Xuehong; Xie, Jing; Lin, Wanli; Wu, Bomeng; Chen, Ying; Huang, Jiawei; Gong, Lanjuan] Guangdong Oesophageal Canc Inst, Gaozhou Branch, Gaozhou, Peoples R China.
   [Gong, Lanjuan] Gaozhou Peoples Hosp, Nursing Dept, Maoming, Guangdong, Peoples R China.
RP Huang, JW; Gong, LJ (通讯作者)，Gaozhou Peoples Hosp, Dept Thorac Surg, Maoming, Guangdong, Peoples R China.; Huang, JW; Gong, LJ (通讯作者)，Guangdong Oesophageal Canc Inst, Gaozhou Branch, Gaozhou, Peoples R China.; Gong, LJ (通讯作者)，Gaozhou Peoples Hosp, Nursing Dept, Maoming, Guangdong, Peoples R China.
EM hjw15992198147@163.com; gonglanjuan8161@163.com
FU Guangdong Medical Research Fund Project [B2023212]; Guangdong Provincial
   Oesophageal Cancer Research Institute Science and Technology Plan
   Project [M202410]
FX The author(s) declare financial support was received for the research
   and/or publication of this article. This work was supported by the
   Guangdong Medical Research Fund Project in 2023 (B2023212) and the
   Guangdong Provincial Oesophageal Cancer Research Institute Science and
   Technology Plan Project (M202410).
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NR 18
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD DEC 1
PY 2025
VL 15
AR 1644593
DI 10.3389/fonc.2025.1644593
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA U8261
UT WOS:001638988400001
PM 41404061
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Geierlehner, A
   Horch, RE
   Müller-Seubert, W
   Arkudas, A
   Ludolph, I
AF Geierlehner, Alexander
   Horch, Raymund E.
   Mueller-Seubert, Wibke
   Arkudas, Andreas
   Ludolph, Ingo
TI Limb salvage procedure in immunocompromised patients with
   therapy-resistant leg ulcers-The value of ultra-radical debridement and
   instillation negative-pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE chronic leg ulcer; negative-pressure wound therapy; skin
   transplantation; ultra-radical debridement
ID DIABETIC FOOT ULCERS; SURGICAL-TREATMENT; SKIN-GRAFT; MANAGEMENT; FLAP;
   RECONSTRUCTION; ULCERATION; AMPUTATION; ETIOLOGY; CLOSURE
AB The purpose of this study was to analyse the outcome of our established triple treatment strategy in therapy-resistant deep-thickness chronic lower leg ulcers. This limb salvage approach consists of ultra-radical surgical debridement, negative-pressure wound therapy (NPWT) with or without instillation, and split-thickness skin grafting. Between March 2003 and December 2019, a total of 16 patients and 24 severe cases of lower leg ulcers were eligible for inclusion in this highly selective population. A total of seven patients received immunosuppressive medication. Complete wound closure was achieved in 25% and almost 90% of included lower leg ulcer cases after 3 and 24 months of our triple treatment strategy, respectively. The overall limb salvage rate was 100%. Bacterial colonisation of these wounds was significantly reduced after multiple surgical debridements and NPWT. Fasciotomy and radical removal of devitalised tissue such as deep fascia, tendons, and muscles combined with NPWT showed promising results in terms of the overall graft take rate. This treatment strategy was considered as last resort for limb salvage in such a critically ill and immunocompromised patient population. Surgeons should be aware of its efficacy and consider the triple treatment strategy especially if no other limb salvage option remains.
C1 [Geierlehner, Alexander; Horch, Raymund E.; Mueller-Seubert, Wibke; Arkudas, Andreas; Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nuernberg FAU, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Univ Hosp Erlangen, Krankenhausstr 12, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Geierlehner, A (通讯作者)，Friedrich Alexander Univ Erlangen Nuernberg FAU, Dept Plast & Hand Surg, Lab Tissue Engn & Regenerat Med, Univ Hosp Erlangen, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM alexander.geierlehner@uk-erlangen.de
RI Arkudas, Andreas/AAQ-6745-2021; Horch, Raymund E/H-8128-2019
OI Arkudas, Andreas/0000-0002-2473-5816; Horch, Raymund
   E/0000-0002-6561-2353
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NR 67
TC 16
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1496
EP 1507
DI 10.1111/iwj.13428
EA JUN 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000541719100001
PM 32573103
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Napolitano, RJ Jr
AF Napolitano Jr., Ralph J.
TI Negative Pressure Wound Therapy with Instillation in Lower Extremity
   Wounds May Contribute to Cost- Savings: 4 Case Reports
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Wound Management; Wound Care; Negative Pressure Wound Therapy
ID DWELL TIME; MANAGEMENT; OUTCOMES; CARE
AB Background: Use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) can assist with wound bed preparation for successful closure. The authors present their experience using NPWTi-d to manage lower extremity wounds in 4 patients and discuss the feasibility of improving cost efficiency. Methods: NPWTi-d involved instillation of normal saline with an 8-to 10 minute dwell time, followed by 3 to 3.5 hours of-125 mm Hg. Therapy continued for 6 to 7 days with dressing changes every 2 to 3 days. Results: Patients were all male, between the ages of 24 and 83 years old. Wound etiologies included chemical burn, deep tissue laceration, compartment syndrome with hematoma, and diabetic foot osteomyelitis. All wounds required cleansing. Prior to NPWTi-d, surgical debridement and antibiotics were administered as necessary. After NPWTi-d, the wounds exhibited healthy granulation and reduced in size, allowing for discharge to outpatient care. Upon follow-up 2 to 6 months later, no patients experienced wound complications or required readmission to the operating room, potentially saving on time and cost. Conclusion: In these patients, use of NPWTi-d assisted in cleansing the wound surface and producing a positive healing outcome. Despite higher initial costs of NPWTi-d over standard dressings, a wound management protocol including NPWTi-d may help mitigate expenses incurred by delayed healing.
C1 [Napolitano Jr., Ralph J.] OrthoNeuro, Columbus, OH USA.
   [Napolitano Jr., Ralph J.] Ohio Univ, Heritage Coll Osteopath Med, Dublin, OH USA.
   [Napolitano Jr., Ralph J.] 191 W Union St, Athens, OH 45701 USA.
C3 University System of Ohio; Ohio University
RP Napolitano, RJ Jr (通讯作者)，191 W Union St, Athens, OH 45701 USA.
EM drralph@newalbanydpm.com
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NR 23
TC 1
Z9 2
U1 1
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAY
PY 2023
VL 69
IS 2
BP 32
EP 38
DI 10.25270/wmp.2023.2.22058
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J4YQ1
UT WOS:001009693300004
PM 37253702
DA 2026-07-24
ER

PT J
AU McElroy, EF
AF McElroy, Elizabeth F.
TI Use of negative pressure wound therapy with instillation and a
   reticulated open cell foam dressing with through holes in the acute care
   setting
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE advanced practice nursing; negative pressure wound therapy; wound
   healing
AB Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an automated system used to deliver, dwell, and remove topical solutions from the wound bed. Recently, a reticulated open cell foam dressing with through holes (ROCF-CC) was developed, which assists with wound cleansing by removing thick exudate and infectious materials. We present our experience using NPWTi-d with ROCF-CC on complex wounds when complete surgical debridement was inappropriate because of medical instability, recurrent non-viable tissue, or palliative treatment plan. For all wounds, NPWTi-d with ROCF-CC was initiated by instilling normal saline, acetic acid, or hypochlorous acid with 2 to 10 minutes of dwell time, followed by 0.5 to 4 hours of negative pressure. Dressings were changed every 2 to 3 days. Fourteen patients with multiple comorbidities were treated for wound types including diabetic foot ulcers, necrotising fasciitis, dehisced wounds, and pressure injuries. Duration of NPWTi-d with ROCF-CC ranged from 1 to 15 days, and at dressing changes, wounds showed improved granulation tissue formation, less malodour, less surrounding erythema, and demarcation of healthy skin from devitalised tissue. Based on these patients, adjunctive use of NPWTi-d with ROCF-CC provided a practical option for improving tissue quality in wounds for patients in whom surgical debridement was not possible or desired.
C1 [McElroy, Elizabeth F.] Reading Hosp, Tower Hlth Syst, Sixth Ave & Spruce St, W Reading, PA 19603 USA.
RP McElroy, EF (通讯作者)，Reading Hosp, Tower Hlth Syst, Sixth Ave & Spruce St, W Reading, PA 19603 USA.
EM elizabeth.mcelroy@towerhealth.org
RI /AAY-9683-2020
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 15
TC 14
Z9 19
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2019
VL 16
IS 3
BP 781
EP 787
DI 10.1111/iwj.13097
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IF2PL
UT WOS:000472920000024
PM 30784210
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Liu, YJ
   Xu, MZ
   Wang, Z
   Zhu, XS
   Xu, JG
AF Liu, Yanjun
   Xu, Mingze
   Wang, Zheng
   Zhu, Xiaoshu
   Xu, Jianguo
TI 被撤回的出版物: The effect of incisional negative pressure wound therapy on the
   improvement of postoperative cosmetic suture wounds and scar hyperplasia
   (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE cosmetic suture wound; effectivity; incisional negative pressure wound
   therapy; scar hyperplasia
ID MANAGEMENT; COMPLICATIONS
AB This study aimed to explore the effects of early incisional negative pressure wound therapy (INPWT) on cosmetic suture wounds and postoperative scar hyperplasia. We retrospectively evaluated 120 patients who underwent abdominoperineal resection at the Changhai Hospital between February 2018 and October 2021 and divided them into two groups according to their treatment: the INPWT group (n = 60) and the control group (n = 60). The quality of post-surgical wound healing in the two groups was evaluated. The Patient Scar Assessment Scale (PSAS), the Vancouver Scar Scale (VSS), and the visual analogue scale (VAS) were used to evaluate the surgical incision scar at 1-year follow-up. At this follow-up visit, 115 patients underwent reexamination; five patients were lost to follow-up, including two patients in the INPWT group and three patients in the control group. The INPWT group showed better wound healing than the control group (P < .05). The proportion of patients who received INPWT was significantly higher in the non-surgical site infection (SSI) group than in the SSI group (P < .05). The PSAS, VSS and VAS scores were significantly improved in the INPWT group compared with those in the control group (P < .05). Our results show that INPWT improved the quality of cosmetic suture wounds and reduced the degree of postoperative scar hyperplasia.
C1 [Liu, Yanjun; Xu, Mingze; Wang, Zheng; Zhu, Xiaoshu; Xu, Jianguo] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Xu, Jianguo] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Xu, JG (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
EM xujg@smmu.edu.cn
RI XU, MINGZE/AAM-5942-2021; Xu, Jian-Guo/JZD-9552-2024
OI Xu, Jian-Guo/0000-0003-2514-5057
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
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NR 22
TC 7
Z9 9
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2023
VL 20
IS 8
BP 3081
EP 3087
DI 10.1111/iwj.14183
EA APR 2023
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S0FS0
UT WOS:000978224600001
PM 37114415
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Krupová, L
   Pokorná, A
   Jarosová, D
AF Krupova, L.
   Pokorna, A.
   Jarosova, D.
TI The use of negative pressure wound therapy in a selected medical
   facility
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE hospital information system -; negative pressure wound therapy;
   retrospective study&nbsp; wound healing
ID MANAGEMENT
AB Aim: The purpose of study was to analyse the use of negative pressure wound therapy (NPWT) in a selected university hospital in the Czech Republic. Patients and methods: A retrospective non -interventional study. The sample included all records of inpatients treated by NPWT in a selected medical facility (university hospital) in the period from 2015 to 2017. Data was extracted from the university hospital information system. Results: NPWT was reported in 276 hospitalized patients. The mean time of application of NPWT was 19 days (median 10), the average number of dressing changes was 3.74 (median 2), and the exchange interval was once every 2.99 days (median 2.33). Detailed analysis of 2017 showed that in the vast majority of cases the outcome of NPWT treatment was positive (N = 77, 84.62%), in only two cases the effect was not beneficial (2.20%) and rest of cases was not possible to assess clearly (N = 12, 13.19%). Conclusion: NPWT is an effective treatment for wounds of many different aetiologies, but there are differences in its use. As we identified different approaches in application and lack of standardisation, we assume that education of health care providers in this area is a necessary and essential aspect to support the appropriate use of NPWT and for the unification of procedures for the quality of care improvement.
C1 [Krupova, L.] Univ Hosp Ostrava, Dermatol Dept, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Krupova, L.; Jarosova, D.] Univ Ostrava, Fac Med, Dept Hlth Sci, Ostrava, Czech Republic.
   [Pokorna, A.] Masaryk Univ Brno, Dept Hlth Sci, Brno, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Masaryk University
RP Krupová, L (通讯作者)，Univ Hosp Ostrava, Dermatol Dept, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
EM lenka.krupova@fno.cz
RI Krupová, Lenka/AFO-2325-2022; Pokorná, Andrea/E-5483-2019; Jarosova,
   Darja/D-7464-2014
OI Krupová, Lenka/0000-0003-4834-4614; Pokorná, Andrea/0000-0002-1305-6455;
   
FU student grant competi- tion of the University of Ostrava; 
   [SGS13/LF/2018]
FX Acknowledgement The article relates to the research grant project
   SGS13/LF/2018 - Optimalization of use of NPTW in University hospital
   Ostrava, supported by student grant competi- tion of the University of
   Ostrava.
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NR 17
TC 0
Z9 0
U1 0
U2 6
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2022
VL 85
SU 1
BP S15
EP S20
DI 10.48095/cccsnn2022S15
PG 6
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7R5DH
UT WOS:000910092300001
DA 2026-07-24
ER

PT J
AU Zhong, MF
   Guo, JW
   Qahar, M
   Huang, GT
   Wu, J
AF Zhong, Meifang
   Guo, Jiawei
   Qahar, Mulan
   Huang, Guangtao
   Wu, Jun
TI Combination therapy of negative pressure wound therapy and
   antibiotic-loaded bone cement for accelerating diabetic foot ulcer
   healing: A prospective randomised controlled trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE antibiotic-loaded bone cement; chronic foot ulcer; clinical therapy;
   negative pressure wound therapy; type 2 diabetes; wound bed preparation
ID LOWER-LIMB AMPUTATION; RISK; MACROPHAGES
AB Negative pressure wound therapy (NPWT) and antibiotic-loaded bone cement (ALBC) are commonly used treatments for diabetic foot ulcers (DFUs). However, the combined efficacy of these two modalities remains unclear. This clinical study aimed to assess the effectiveness and underlying mechanisms of NPWT&ALBC in the management of DFUs. A total of 28 patients were recruited, 16 of whom served as controls and received only NPWT, whilst 12 received NPWT&ALBC. Both groups underwent wound repair surgery following the treatments. Blood samples were obtained to detect infections and inflammation. Wound tissue samples were also collected before and after the intervention to observe changes in inflammation, vascular structure and collagen through tissue staining. Compared with the NPWT group, the NPWT&ALBC group exhibited a superior wound bed, which was characterised by reduced inflammation infiltration and enhanced collagen expression. Immunostaining revealed a decrease in IL-6 levels and an increase in alpha-SMA, CD68, CD206 and collagen I expression. Western blot analysis demonstrated that NPWT&ALBC led to a decrease in inflammation levels and an increase in vascularization and collagen content. NPWT&ALBC therapy tends to form a wound bed with increased vascularization and M2 macrophage polarisation, which may contribute to DFUs wound healing.
C1 [Zhong, Meifang; Huang, Guangtao; Wu, Jun] Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Burn & Plast Surg, Shenzhen 518028, Peoples R China.
   [Guo, Jiawei] Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Hand & Foot Surg, Shenzhen, Peoples R China.
   [Guo, Jiawei] Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound,Med S, Shenzhen, Peoples R China.
   [Qahar, Mulan] Shenzhen Inst Translat Med, Shenzhen, Peoples R China.
C3 Shenzhen University; Shenzhen University; Shenzhen University
RP Huang, GT; Wu, J (通讯作者)，Shenzhen Univ, Shenzhen Peoples Hosp 2, Hosp 1, Dept Burn & Plast Surg, Shenzhen 518028, Peoples R China.
EM haitao3140@sina.com; junwupro@126.com
RI Guo, Jiawei/JMH-1084-2023
FU National Key Clinical Specialty ([2023] No. 25) [2000022]; The Project
   funded by China Postdoctoral Science Foundation [2023M742413]; Burns,
   Plastic Surgery, and Wound Repair, Guangtao Huang Scientific Research
   Startup Fund [4004050]; Shenzhen Science and Technology Program
   [JCYJ20230807115121043]
FX This work was supported by National Key Clinical Specialty ([2023] No.
   25) (2000022); Burns, Plastic Surgery, and Wound Repair, Guangtao Huang
   Scientific Research Startup Fund (4004050); the Project funded by China
   Postdoctoral Science Foundation (2023M7 42413) and Shenzhen Science and
   Technology Programme (JCYJ20230807115121043).
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NR 38
TC 14
Z9 21
U1 4
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2024
VL 21
IS 10
AR e70089
DI 10.1111/iwj.70089
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DD2ZD
UT WOS:001680693800001
PM 39379061
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lavery, LA
   Davis, KE
   La Fontaine, J
   Farrar, JD
   Bhavan, K
   Oz, OK
   Crisologo, PA
AF Lavery, Lawrence A.
   Davis, Kathryn E.
   La Fontaine, Javier
   Farrar, J. David
   Bhavan, Kavita
   Oz, Orhan K.
   Crisologo, Peter A.
TI Does negative pressure wound therapy with irrigation improve clinical
   outcomes? A randomized clinical trial in patients with diabetic foot
   infections
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Infection; Diabetes; Ulcer; Negative pressure wound therapy; Amputation;
   Osteomyelitis
ID MULTICENTER; INSTILLATION; ULCERS; OSTEOMYELITIS; MANAGEMENT; EFFICACY;
   SAFETY
AB Aim: To compare the efficacy of Negative Pressure Wound Therapy (NPWT) with and without irrigation with 0.1% polyhexanide-betaine.
   Methods: We randomized 150 subjects in a 16-week RCT to compare healing in patients with diabetic foot infections. NPWT delivered at 125 mm Hg continuous pressure. NPWT-I were administered at 30 cc per hour.
   Results: There were no differences clinical treatment or outcomes: wound area after surgery (18.5 +/- 19.0 vs. 13.4 +/- 11.1 cm2, p = 0.50), duration of antibiotics (39.7 +/- 21.0 vs. 38.0 +/- 24.6 days, p = 0.40), number of surgeries (2.3 +/- 0.67 vs. 2.2 +/- 0.59, p = 0.85), duration of NPWT (148.1 +/- 170.4 vs. 114.5 +/- 135.1 h, p = 0.06), healed wounds (58.7% vs. 60.0%, p = 0.86), time to healing (56.3 +/- 31.7 vs. 50.7 +/- 27.8, p = 0.53), length of stay (13.8 +/- 6.4 vs. 14.5 +/- 11.2 days, p = 0.42), re-infection (20.0% vs. 22.7%, p = 0.69, and re-hospitalization (17.3% vs. 18.7, p = 0.83).
   Conclusions: The addition of irrigation to NPWT did not change clinical outcomes in patients with diabetic foot infections. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Lavery, Lawrence A.; Davis, Kathryn E.; La Fontaine, Javier; Crisologo, Peter A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Farrar, J. David] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol & Mol Biol, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Bhavan, Kavita] Univ Texas Southwestern Med, Dept Internal Med, Infect Dis, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Oz, Orhan K.] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.
   [Crisologo, Peter A.] Univ Cincinnati, Med Ctr, Dept Surg, 231 Albert Sabin Way,ML 0513, Cincinnati, OH 45267 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; University of Texas System; University of Texas
   Southwestern Medical Center; University of Texas System; University of
   Texas Southwestern Medical Center; University System of Ohio; University
   of Cincinnati
RP Lavery, LA; Crisologo, PA (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75219 USA.; Crisologo, PA (通讯作者)，Univ Cincinnati, Med Ctr, Dept Surg, 231 Albert Sabin Way,ML 0513, Cincinnati, OH 45267 USA.
EM larry.lavery@utsouthwestern.edu; crisolpa@ucmail.uc.edu
RI Crisologo, Peter/JZE-5379-2024; Oz, Orhan/GVT-7264-2022
OI Crisologo, Peter/0000-0002-5367-9235; Lavery,
   Lawrence/0000-0002-7920-9952; 
FU American Diabetes Association [1-15-TS-20, 1-17-ICTS-056]
FX This study was funded and supported by the American Diabetes Association
   award numbers [1-15-TS-20] and [1-17-ICTS-056].
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NR 20
TC 25
Z9 29
U1 0
U2 12
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD OCT
PY 2020
VL 220
IS 4
BP 1076
EP 1082
DI 10.1016/j.amjsurg.2020.02.044
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OA0ZX
UT WOS:000577526000052
PM 32139102
DA 2026-07-24
ER

PT J
AU Yang, YS
   Liu, MD
   Yang, FF
   Wang, XJ
   Bai, XZ
   Mu, SZ
   Liu, Y
   Hu, DH
AF Yang, Yunshu
   Liu, Mengdong
   Yang, Fangfang
   Wang, Xujie
   Bai, Xiaozhi
   Mu, Shengzhi
   Liu, Yang
   Hu, Dahai
TI Circular RNA expression profiles following negative pressure wound
   therapy in burn wounds with experimental Pseudomonas aeruginosa
   infection
SO BIOENGINEERED
LA English
DT Article
DE Circular RNAs; negative pressure wound therapy; burn wound; Pseudomonas
   aeruginosa; whole-transcriptome sequencing
ID NONCODING RNAS; PERFUSION; MICRORNA
AB Infections of burn wounds, especially those caused by Pseudomonas aeruginosa, could trigger sepsis or septic shock, which is the main cause of death after burn injury. Compared with traditional saline-wet-to-dry dressings, negative pressure wound therapy (NPWT) is more effective for the prevention and treatment of wound infections. However, the mechanism by which NPWT controls infection and accelerates wound healing remains unclear. Accordingly, in this study, the molecular mechanisms underlying the effects of NPWT were explored using a murine model of P. aeruginosa-infected burn wounds. NPWT significantly reduced P. aeruginosa levels in wounds, enhanced blood flow, and promoted wound healing. Additionally, NPWT markedly alleviated wound inflammation and increased the expression of wound healing-related molecules. Recent evidence points to a role of circular RNAs (circRNAs) in wound healing; hence, whole-transcriptome sequencing of wound tissues from NPWT and control groups was performed to evaluate circRNA expression profiles. In total, 12 up-regulated and 25 down-regulated circRNAs were identified between groups. Among these, five significant differentially expressed circRNAs acting as microRNA sponges were identified, and their predicted targets were verified by reverse transcription-quantitative polymerase chain reaction. These results further support the roles of circRNAs in wound healing by NPWT and the prevention of P. aeruginosa infection, providing key molecular targets for further functional analyses.
C1 [Yang, Yunshu; Liu, Mengdong; Wang, Xujie; Bai, Xiaozhi; Liu, Yang; Hu, Dahai] Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, 029-84775295,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Yang, Fangfang] Northwest Univ, Sch Life Sci, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Xian, Shaanxi, Peoples R China.
   [Mu, Shengzhi] Shaanxi Prov Peoples Hosp, Dept Burn & Plast Surg, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University; Northwest University Xi'an; Xi'an Medical
   University
RP Hu, DH (通讯作者)，Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, 029-84775295,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.; Liu, Y (通讯作者)，029-84775298,127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM 866915@qq.com; hudhai@fmmu.edu.cn
RI Bai, xbai/LMN-4476-2024; Yang, Fangfang/HJH-3693-2023; Yang,
   Yunshu/IXD-9094-2023
FU National Natural Science Foundation of China [81501666]; Natural Science
   Foundation of Shaanxi Province [2021JM-249]; Special Science Research
   Program for National Health and Public Welfare Industry in China
   [201502015]
FX This work was supported by the National Natural Science Foundation of
   China [81501666], Natural Science Foundation of Shaanxi Province
   [2018JQ8049], Natural Science Foundation of Shaanxi Province
   [2021JM-249] and Special Science Research Program for National Health
   and Public Welfare Industry in China [201502015].
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NR 35
TC 7
Z9 7
U1 1
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2165-5979
EI 2165-5987
J9 BIOENGINEERED
JI Bioengineered
PD FEB 1
PY 2022
VL 13
IS 2
BP 4122
EP 4136
DI 10.1080/21655979.2021.2006965
PG 15
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA ZI6TB
UT WOS:000761750400001
PM 34898366
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, S
   Xie, YL
   Yan, FF
   Zhang, YF
   Yang, ZQ
   Chen, Z
   Zhao, Y
   Huang, Z
   Cai, L
   Deng, ZM
AF Zhang, Sheng
   Xie, Yuanlong
   Yan, Feifei
   Zhang, Yufeng
   Yang, Zhiqiang
   Chen, Zhe
   Zhao, Yong
   Huang, Zan
   Cai, Lin
   Deng, Zhouming
TI Negative pressure wound therapy improves bone regeneration by promoting
   osteogenic differentiation via the AMPK-ULK1-autophagy axis
SO AUTOPHAGY
LA English
DT Article
DE AMPK; bone nonunion; bone regeneration; macroautophagy; autophagy;
   mesenchymal stem cells; negative pressure wound therapy; osteoblast
   differentiation; ULK1
ID MESENCHYMAL STEM-CELLS; NON-UNIONS; R PACKAGE; AMPK; PHOSPHORYLATION;
   AUTOPHAGY; SIZE; PROLIFERATION; MECHANISMS; GUIDELINES
AB Deficient bone regeneration causes bone defects or nonunion in a substantial proportion of trauma patients that urges for novel therapies. To develop a reliable therapy, we investigated the effect of negative pressure wound therapy (NPWT) on bone regeneration in vivo in a rat calvarial defect model. Negative pressure (NP) treatment in vitro was mimicked to test its effect on osteoblast differentiation in rat mesenchymal stem cells (MSCs) and MC3T3-E1 cells. Transcriptomic analyses, pharmaceutical interventions, and shRNA knockdowns were conducted to explore the underlying mechanism and their clinical relevance was investigated in samples from patients with nonunion. The potential application of a combined therapy of MSCs in hydrogels with negative pressure was tested in the rat critical-size calvarial defect model. We found that NPWT promoted bone regeneration in vivo and NP treatment induced osteoblast differentiation in vitro. NP induced osteogenesis via activating macroautophagy/autophagy by AMPK-ULK1 signaling that was impaired in clinical samples from patients with nonunion. More importantly, the combined therapy involving MSCs in hydrogels with negative pressure significantly improved bone regeneration in rat critical-size calvarial defect model. Thus, our study identifies a novel AMPK-ULK1-autophagy axis by which negative pressure promotes osteoblast differentiation of MSCs and bone regeneration. NPWT treatment can potentially be adopted for therapy of bone defects.
C1 [Zhang, Sheng; Xie, Yuanlong; Yan, Feifei; Zhang, Yufeng; Yang, Zhiqiang; Chen, Zhe; Zhao, Yong; Cai, Lin; Deng, Zhouming] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 163 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
   [Huang, Zan] Wuhan Univ, Dept Biochem, Key Lab Cell Hemostasis Hubei Prov, Coll Life Sci, Wuhan, Hubei, Peoples R China.
   [Huang, Zan] Shanghai Childrens Hosp, Nhc Key Lab Med Embryogenesis & Dev Mol Biol, Shanghai Key Lab Embryo & Reprod Engn, Shanghai, Peoples R China.
C3 Wuhan University; Wuhan University; Shanghai Jiao Tong University
RP Cai, L; Deng, ZM (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 163 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.; Huang, Z (通讯作者)，Wuhan Univ, Coll Life Sci, Key Lab Cell Hemostasis Hubei Prov, 299 Bayi Rd, Wuhan 430072, Hubei, Peoples R China.
EM z-huang@whu.edu.cn; orthopedics@whu.edu.cn; dengzhouming@foxmail.com
RI Zhang, Yufeng/GZL-1973-2022; Xie, Yuanlong/V-7190-2019; Yan,
   Feifei/GRX-6364-2022
OI Zhang, Yufeng/0000-0003-3610-5229; Deng, Zhouming/0000-0003-3473-4101;
   Zhang, Sheng/0000-0002-1436-4265; Deng, Zhouming/0000-0003-3052-6241;
   Cai, Lin/0000-0003-3126-6429; 
FU National Natural Science Foundation of China [81870162, 81870427,
   81702150]
FX This work was supported by the National Natural Science Foundation of
   China [81870162]; National Natural Science Foundation of China
   [81870427]; National Natural Science Foundation of China [81702150].
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NR 51
TC 108
Z9 118
U1 1
U2 83
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1554-8627
EI 1554-8635
J9 AUTOPHAGY
JI Autophagy
PD SEP 2
PY 2022
VL 18
IS 9
BP 2229
EP 2245
DI 10.1080/15548627.2021.2016231
EA DEC 2021
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3X3NQ
UT WOS:000735815300001
PM 34964701
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhu, BZ
   Cao, DS
   Xie, J
   Li, HH
   Chen, ZH
   Bao, Q
AF Zhu, BangZhong
   Cao, DongSheng
   Xie, Juan
   Li, HongHong
   Chen, ZengHong
   Bao, Qiong
TI Clinical experience of the use of Integra in combination with negative
   pressure wound therapy: an alternative method for the management of
   wounds with exposed bone or tendon
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Integra; take rate; time; negative pressure wound therapy
AB The use of Integra has attracted great interest in the treatment of wounds with exposed bone or tendon, which may lead to associated morbidities. However, the use of Integra alone results in poor wound outcomes. We conducted a randomized clinical study to evaluate the combined effects of Integra and negative pressure wound therapy (NPWT). Thirty-six patients with wounds with exposed bone or tendons were treated with Integra alone and with a combination of Integra and NPWT (n = 18 respectively). Negative pressure (125 mm Hg) was applied intermittently till Integra was revascularized. The take rate of Integra and time taken from Integra coverage to skin transplantation was recorded for each case. The average take rate of Integra in the conventional treatment group (Integra with partial packing compression dressings) was lower than that for the new treatment group (Integra with NPWT) (p < 0.001, 95% CI: 6.44-0.20). The mean time period from Integra coverage to skin transplantation was longer for the conventional treatment group than for the new treatment group (p < 0.001, 95% CI: -13.18 to -11.24). The application of NPWT could potentially increase the take rate of Integra and shorten the duration of hospital stay. The use of Integra with NPWT could be a treatment option for wounds with exposed bone or tendon.
C1 [Zhu, BangZhong; Cao, DongSheng; Xie, Juan; Li, HongHong; Chen, ZengHong; Bao, Qiong] AnHui Med Univ, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, 678 FuRong Rd, Hefei 230601, Peoples R China.
C3 Anhui Medical University
RP Cao, DS (通讯作者)，AnHui Med Univ, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, 678 FuRong Rd, Hefei 230601, Peoples R China.
EM cds1966@sina.com
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NR 22
TC 17
Z9 18
U1 0
U2 10
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD FEB 1
PY 2021
VL 55
IS 1
BP 1
EP 5
DI 10.1080/2000656X.2020.1781140
EA DEC 2020
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA QB0BR
UT WOS:000607236400001
PM 33433246
OA gold
DA 2026-07-24
ER

PT J
AU Cuomo, R
   Grimaldi, L
   Nisi, G
   Zerini, I
   Giardino, FR
   Brandi, C
AF Cuomo, Roberto
   Grimaldi, Luca
   Nisi, Giuseppe
   Zerini, Irene
   Giardino, Francesco Ruben
   Brandi, Cesare
TI Ultraportable Devices for Negative Pressure Wound Therapy: First
   Comparative Analysis
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE negative pressure wound therapy; wound care; ultraportable devices;
   PICO; Nanova; SNaP
AB Background: The author proposes to compare ultraportable devices for Negative Pressure Wound Therapy. Main reviews in literature assert that there is a lack in data about this topic. Materials and Methods: The study was conducted in 3 phases. The first phase involved a deep study of all the characteristics and indications of the ultraportable devices for available NPWT, highlighting dimensions, type of canister, functioning, mmHg negative pressure, the modality of use. The second phase was clinical: we treated 125 patients and described our 2 years experience. We treated the first 25 patients with PICO; then, second 25 patients with Nanova, then Uno, VacVia, and Snap in order to obtain 5 group of 25 patients. The third phase of the study consisted in the collection of data of scientific literature on classic and ultraportable devices: other experiences, multicentric studies, case reports, new suggestions, and other data on the topic were analyzed providing a synthesis of all available information. We made a diagram in order to summarize our experience and to compare the devices. Results: We described the main characteristics, main advantages and disadvantages of all devices. The literature data allowed us to investigate better to these aspects and to confirm the lack in comparing ultraportable negative wound pressure devices. Conclusions: All ultraportable devices have singular characteristics. Physician who want to use them, must know them in order to made appropriate therapy.
C1 [Cuomo, Roberto; Grimaldi, Luca; Nisi, Giuseppe; Zerini, Irene; Giardino, Francesco Ruben; Brandi, Cesare] Univ Siena, Santa Maria Alle Scotte Hosp, Unit Plast & Reconstruct Surg, Siena, Italy.
C3 University of Siena
RP Cuomo, R (通讯作者)，Univ Siena, Santa Maria Alle Scotte Hosp, I-53100 Siena, Italy.
EM robertocuomo@outlook.com
RI Cuomo, Roberto/AFI-8757-2022
OI Cuomo, Roberto/0000-0002-8396-095X; Giardino, Francesco
   Ruben/0000-0003-3293-8936
CR [Anonymous], 2014, Prevention and Treatment of Pressure Ulcers: Quick Reference Guide
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NR 36
TC 19
Z9 20
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD MAR 16
PY 2021
VL 34
IS 3
BP 335
EP 343
DI 10.1080/08941939.2019.1616009
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QL3ZA
UT WOS:000621016800014
PM 31132881
DA 2026-07-24
ER

PT J
AU Giannini, S
   Mazzotti, A
   Luciani, D
   Lullini, G
   Tedesco, G
   Andreoli, I
   Cadossi, M
   Faldini, C
AF Giannini, Sandra
   Mazzotti, Antonio
   Luciani, Deianira
   Lullini, Giada
   Tedesco, Giuseppe
   Andreoli, Isabella
   Cadossi, Matteo
   Faldini, Cesare
TI Postoperative wound management with negative pressure wound therapy in
   knee and hip surgery: a randomised control trial
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE ASEPSIS score; negative pressure wound therapy; postoperative wound
   management; standard wound dressing
ID CLOSED SURGICAL INCISIONS; ARTHROPLASTY; SITE; COMPLICATIONS;
   INFECTIONS; FRACTURES; SURVIVAL
AB Objective: To compare the effectiveness in wound healing of negative pressure wound therapy (NPWT) versus a standard dressing in patients who underwent hip or knee revision surgery.
   Method: Participating patients scheduled for hip and knee prosthetic revision were randomised into two groups: one receiving standard povidone-iodine gauze and patch wound dressing (control group) and the other NPWT over the sutured wound area (NPWT group). Patients were evaluated by means of ASEPSIS score, occurrence of blisters, visual analogue scale (VAS) and dressing changes seven days after surgery. We hypothesised a five-point difference in ASEPSIS scores as clinically relevant.
   Results: A total of 110 patients were enrolled in the study. Mean ASEPSIS score was 5.1 for the control group and 3.0 for the NPWT group, with a significant difference in the ASEPSIS score between groups (p<0.001), although this was not clinically relevant. Considering patients with more than three risk factors for healing complication, a statistical difference of >5 points ASEPSIS score was recorded (p<0.0005). Blister occurrence, VAS score and number of dressing changes were significantly lower in the NPWT group.
   Conclusion: The results of this study do not support the routine use of NPWT after hip and knee revision. However, it could be beneficial for selected patients once specific risk factors for wound healing complications have been determined.
C1 [Giannini, Sandra; Mazzotti, Antonio; Lullini, Giada; Cadossi, Matteo; Faldini, Cesare] Univ Bologna, Biomed & Neuromotorial Sci Dept, Bologna, Italy.
   [Mazzotti, Antonio; Luciani, Deianira; Lullini, Giada; Tedesco, Giuseppe; Andreoli, Isabella; Cadossi, Matteo; Faldini, Cesare] Ist Ortoped Rizzoli, Clin Orthopaed & Traumatol, Bologna, Italy.
C3 University of Bologna; IRCCS Istituto Ortopedico Rizzoli
RP Lullini, G (通讯作者)，Univ Bologna, Biomed & Neuromotorial Sci Dept, Bologna, Italy.; Lullini, G (通讯作者)，Ist Ortoped Rizzoli, Clin Orthopaed & Traumatol, Bologna, Italy.
EM Giada.lullini@hotmail.it
RI Tedesco, Giuseppe/K-2495-2018; Mazzotti, Antonio/ABI-2083-2020
OI Tedesco, Giuseppe/0000-0001-8906-3566; 
FU Smith Nephew
FX S.G. worked as a consultant and received honoraria from Smith & Nephew.
   All other authors have no conflict of interests. This study was
   financially supported by Smith & Nephew.
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   Stannard JP, 2012, INT WOUND J, V9, P32, DOI 10.1111/j.1742-481X.2012.01017.x
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
   Steck JK, 2017, CLIN PODIATR MED SUR, V34, P541, DOI 10.1016/j.cpm.2017.05.010
   WILSON APR, 1986, LANCET, V1, P311
   Zhan CL, 2003, JAMA-J AM MED ASSOC, V290, P1868, DOI 10.1001/jama.290.14.1868
NR 26
TC 24
Z9 25
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2018
VL 27
IS 8
BP 520
EP 525
DI 10.12968/jowc.2018.27.8.520
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GP5VK
UT WOS:000440943300008
PM 30086252
DA 2026-07-24
ER

PT J
AU Loh, ML
   Goh, BKL
   Kong, Y
   Varughese, G
   Ng, JL
   Lo, ZWJ
   Pek, CH
AF Loh, Mei Ling
   Goh, Benjamin K. L.
   Kong, Yuan
   Varughese, George
   Ng, Jia Lin
   Lo, Zhiwen J.
   Pek, Chong Han
TI Combination therapy of oxidised regenerated cellulose/collagen/silver
   dressings with negative pressure wound therapy for coverage of exposed
   critical structures in complex lower-extremity wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cellulose; oxidised; collagen; lower extremity; negative pressure wound
   therapy; wounds and healing
ID MANAGEMENT; MATRIX; REPAIR
AB Complex wounds with exposed critical structures such as tendon and bone are a conundrum in wound management, especially in the setting where the patient is not a suitable candidate for flap surgery. While the individual use of negative pressure wound therapy (NPWT) and oxidised regenerated cellulose (ORC)/collagen/silver (PROMOGRAN PRISMA) dressing has been described in the literature, there are little data on the efficacy of their combined use. In this study, we describe a novel technique of combining the use of NPWT and ORC/collagen/silver dressings to manage complex wound beds as an alternative management option for patients not suitable for reconstructive flap surgery. This technique was performed in a series of 37 patients with complex lower-extremity wounds that were not healing with conventional NPWT alone. All patients had open wounds with exposed critical structures that were difficult to manage, such as exposed tendon, bone, deep crevices, and joint. Successful coverage of exposed critical structures was achieved in 89% of patients, and coverage was achieved within 28 days of combination therapy in 82% of these patients, without any complications. The novel technique of combining ORC/collagen/silver dressing and NPWT provides a useful option in the armamentarium of a reconstructive surgeon dealing with difficult complex lower-extremity wounds.
C1 [Loh, Mei Ling; Goh, Benjamin K. L.; Kong, Yuan; Varughese, George; Pek, Chong Han] Khoo Teck Puat Hosp, Dept Gen Surg Plast Reconstruct & Aesthet Surg Se, 90 Yishun Cent, Singapore 768828, Singapore.
   [Ng, Jia Lin] Khoo Teck Puat Hosp, Dept Podiatry, Singapore, Singapore.
   [Lo, Zhiwen J.] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, Singapore, Singapore.
C3 Tan Tock Seng Hospital
RP Pek, CH (通讯作者)，Khoo Teck Puat Hosp, Dept Gen Surg Plast Reconstruct & Aesthet Surg Se, 90 Yishun Cent, Singapore 768828, Singapore.
EM pek.chong.han@ktph.com.sg
RI ; Pek, Chong Han/AAJ-2977-2020
OI LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Pek, Chong
   Han/0000-0002-1354-9399; Loh, Mei Ling/0009-0007-2411-8694
CR Arnold-Long M, 2010, J WOUND OSTOMY CONT, V37, P549, DOI 10.1097/WON.0b013e3181eda751
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NR 22
TC 12
Z9 14
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1356
EP 1365
DI 10.1111/iwj.13406
EA MAY 2020
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000534955800001
PM 32447838
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Nicolosi, B
   Curcio, F
   Maffeo, M
   Di Leva, M
   Gregorini, M
   Buccione, E
   Coletta, R
AF Nicolosi, Biagio
   Curcio, Felice
   Maffeo, Marina
   Di Leva, Marika
   Gregorini, Mirco
   Buccione, Emanuele
   Coletta, Riccardo
TI Early Use of Incisional Negative Pressure Wound Therapy in Pediatric
   Abdominal and Thoracic Surgery: A Single-Center Retrospective Study on
   Clinical and Economic Outcomes
SO CHILDREN-BASEL
LA English
DT Article
DE negative pressure wound therapy; pediatric surgery; surgical wound
   complications; wound healing; economic outcomes; incisional NPWT
ID INFECTIONS; CHILDREN
AB Aim: To evaluate the effectiveness and economic impact of early Incisional Negative Pressure Wound Therapy (iNPWT) in promoting surgical wound healing in pediatric patients undergoing abdominal and thoracic surgery. Background: Surgical wound complications, such as dehiscence and infection, are frequent in pediatric patients, especially in high-risk cases. Although iNPWT is increasingly used in surgical care, evidence supporting its efficacy in pediatric populations remains limited. Methods: This single-center, retrospective observational study analyzed 49 pediatric patients who underwent abdominal or thoracic surgery between January and December 2023. Patients received either intraoperative iNPWT (early application) or standard dressings. The outcomes assessed included time to complete wound healing, incidence of complications, pain levels, and healthcare costs. Results: Patients treated with early iNPWT showed significantly faster wound healing and fewer complications-particularly dehiscence and infections-compared to those receiving standard dressing. Pain perception did not significantly differ between groups. Although the initial costs of iNPWT were higher, overall costs were lower due to fewer complications and shorter hospital stays. Conclusions: Early iNPWT is a clinically effective and cost-efficient intervention for pediatric surgical patients at high risk of wound complications. However, limitations related to the retrospective design and small sample size suggest that prospective multicenter studies are needed to confirm these findings and support the development of standardized pediatric protocols.
C1 [Nicolosi, Biagio; Gregorini, Mirco] Meyer Childrens Hosp IRCCS, Healthcare Profess Dept, I-50139 Florence, Italy.
   [Curcio, Felice] Univ Hosp Sassari, Pediat & Neonatal Surg, I-07100 Sassari, Italy.
   [Maffeo, Marina] Meyer Childrens Hosp IRCCS, Pediat Intens Care Unit, I-50139 Florence, Italy.
   [Di Leva, Marika] Univ Florence, Sch Human Hlth Sci, I-50139 Florence, Italy.
   [Buccione, Emanuele] Hlth Local Author Pescara, Pediat Intens Care Unit, I-65124 Pescara, Italy.
   [Coletta, Riccardo] Meyer Childrens Hosp IRCCS, Dept NEUROFARBA, I-50139 Florence, Italy.
C3 University of Sassari; University of Florence
RP Nicolosi, B (通讯作者)，Meyer Childrens Hosp IRCCS, Healthcare Profess Dept, I-50139 Florence, Italy.
EM biagio.nicolosi@meyer.it; felice.curcio@aousassari.it;
   marina.maffeo@meyer.it; emanuele.buccione@asl.pe.it
RI Coletta, Riccardo/AAB-2022-2019; Nicolosi, Biagio/NJS-0720-2025; Curcio,
   Felice/MFK-0726-2025; Buccione, Emanuele/GOJ-9965-2022; , Marina
   Maffeo/LXU-9158-2024
OI Nicolosi, Biagio/0009-0008-6665-1638; Curcio,
   Felice/0000-0001-5759-1065; Buccione, Emanuele/0000-0003-4146-8948; ,
   Marina Maffeo/0009-0004-4155-4381; Di Leva, Marika/0009-0003-7495-531X
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Atkin L, 2019, J WOUND CARE, V28, pS5, DOI 10.12968/jowc.2019.28.Sup3a.S1
   Badin D, 2022, J PEDIATR ORTHOPED, V42, pE1008, DOI 10.1097/BPO.0000000000002255
   Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
   Catania VD, 2019, FRONT PEDIATR, V7, DOI 10.3389/fped.2019.00101
   Cohen J., 2013, SECURITY CONSTITUTIO, P58, DOI 10.4324/9780203771587
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
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   Groenen H, 2023, ECLINICALMEDICINE, V62, DOI 10.1016/j.eclinm.2023.102105
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   Pérez-Acevedo G, 2024, INT WOUND J, V21, DOI 10.1111/iwj.70034
   Santosa KB, 2019, J SURG RES, V235, P560, DOI 10.1016/j.jss.2018.10.043
   Smart H, 2024, ADV SKIN WOUND CARE, V37, P180, DOI 10.1097/ASW.0000000000000120
   van Ramshorst GH, 2009, WORLD J SURG, V33, P1509, DOI 10.1007/s00268-009-0058-7
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   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI [10.1016/j.jclinepi.2007.11.008, 10.1111/j.1468-1293.2008.00605.x, 10.1157/13073893]
   White AJ, 2022, BIOENGINEERING-BASEL, V9, DOI 10.3390/bioengineering9110614
NR 23
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT 23
PY 2025
VL 12
IS 11
AR 1433
DI 10.3390/children12111433
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA F4552
UT WOS:001623558700001
PM 41300551
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Crist, BD
   Oladeji, LO
   Khazzam, M
   Della Rocca, GJ
   Murtha, YM
   Stannard, JP
AF Crist, Brett D.
   Oladeji, Lasun O.
   Khazzam, Michael
   Della Rocca, Gregory J.
   Murtha, Yvonne M.
   Stannard, James P.
TI Role of acute negative pressure wound therapy over primarily closed
   surgical incisions in acetabular fracture ORIF: A prospective randomized
   trial
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative pressure wound therapy; Infection; Acetabular fracture;
   Surgical site infection; Incisional NPWT
ID ORTHOPEDIC-SURGERY; COMPLICATIONS; MANAGEMENT; CLOSURE; IMPACT
AB Background: Negative pressure wound therapy use over closed surgical incisions (iNPWT) has proven to be effective at reducing hematoma, wound drainage and infection in high-risk wounds. The purpose of this study was to determine if iNPWT decreased the risk of infection in patients undergoing open reduction internal fixation (ORIF) for acetabular fractures.
   Methods: 71 patients who underwent operative intervention for an acetabular fracture between March 2008 and September 2012 consented and prospectively randomized to iNPWT or a standard postoperative (dry gauze) dressing. The primary endpoint was deep infection, i.e. necessitating surgical debridement. Patients were followed until fracture union.
   Results: 33 patients were randomized to treatment with a standard gauze dressing and 33 patients were randomized to the iNPWT cohort. There were no statistically significant differences between the groups with respect to patient demographics, clinical, or surgery characteristics. Overall, seven patients (10.6%) were diagnosed with infections; two patients (6.1%) in the placebo group and 5 (15.2%) in the treatment group.
   Conclusions: In this randomized prospective trial, iNPWT did not decrease the incidence of deep infections when compared to gauze dressings in patients with acetabular fractures. Although not statistically significant, patients in the iNPWT cohort were 2.77 times more likely to develop a deep infection. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Crist, Brett D.; Oladeji, Lasun O.; Murtha, Yvonne M.; Stannard, James P.] Univ Missouri, Dept Orthopaed Surg, One Hosp Dr,N116, Columbia, MO 65211 USA.
   [Khazzam, Michael] Univ Texas Southwestern Med Ctr Dallas, Dept Orthopaed Surg, Dallas, TX 75390 USA.
   [Della Rocca, Gregory J.] Duke Univ, Dept Orthopaed Surg, Durham, NC USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Texas System; University of Texas Southwestern Medical
   Center; Duke University
RP Stannard, JP (通讯作者)，Univ Missouri, Dept Orthopaed Surg, One Hosp Dr,N116, Columbia, MO 65211 USA.
EM cristb@health.missouri.edu
RI Crist, Brett/AAC-7535-2019; Della Rocca, Gregory/AAM-5281-2021;
   /AAD-3102-2019
OI Stannard, James P/0000-0001-8467-6494; Oladeji,
   Lasun/0000-0002-6968-5568
CR Brem MH, 2014, INT WOUND J, V11, P3, DOI 10.1111/iwj.12252
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NR 27
TC 47
Z9 51
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUL
PY 2017
VL 48
IS 7
BP 1518
EP 1521
DI 10.1016/j.injury.2017.04.055
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA FB2TW
UT WOS:000405997100037
PM 28477992
DA 2026-07-24
ER

PT J
AU Lehner, B
   Bernd, L
AF Lehner, B
   Bernd, L
TI VAC®-Instill therapy in periprodthetic infection of hip and knee
   arthroplasty
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE periprosthetic infection; early infection; retention of prosthesis;
   vacuum therapy; instillation therapy
ID PROSTHETIC JOINT INFECTION; DEBRIDEMENT; RETENTION; MANAGEMENT
AB Periprosthetic infection represents a main complication of arthroplasty. In case of an early infection the implant often can be left in place. Whether instillation of antiseptic solution using a reticulated sponge in combination with negative pressure wound therapy (V.A.C.(R)-instill) can be useful was the aim of our investigation. Up to now the instillation of Lavasept in combination with negative pressure wound therapy could be performed in three patients. In two cases an early infection of a hip prosthesis and one infected knee implant had to be treated. Following surgical debridement V.A.C.(R)-instill therapy was performed for 4-7 days followed by closure of the wound or a repeated application. Lavasept was used for irrigation. In all three cases retention of the primary implant could be achieved. The follow up now is 8 to 22 weeks. No recurrence of the infection occurred. After salvage of the prosthesis the joint allowed full load bearing and painfree mobilisation. The V.A.C.(R)-instill system proved to be easy to use. With this system early periprosthetic infection with antiseptic irrigation in combination with negative pressure wound therapy decreasing the bacterial burden, salvage of prosthesis seems to be possible. The therapy is applicable in hip and knee prosthesis. Final conclusions about this therapy however can be done only after a larger series of patients.
C1 Stiftung Orthopad Univ Klin, D-69118 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Lehner, B (通讯作者)，Stiftung Orthopad Univ Klin, Schlierbacher Landstr 200 A, D-69118 Heidelberg, Germany.
EM burkhard.lehner@ok.uni-heidelberg.de
CR Bernard L, 2004, J ANTIMICROB CHEMOTH, V53, P127, DOI 10.1093/jac/dkh033
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   FLEISCHMANN W, 2005, VAKUUMTHERAPIE ULM, P35
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NR 19
TC 26
Z9 27
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S160
EP S164
DI 10.1055/s-2006-921513
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100038
PM 16575671
DA 2026-07-24
ER

PT J
AU Polomska, K
   Kowalik, J
   Kobiela, J
   Spychalski, P
AF Polomska, Katarzyna
   Kowalik, Janina
   Kobiela, Jarek
   Spychalski, Piotr
TI Effectiveness of Open Incision Negative Pressure Wound Therapy for
   Surgical Site Infection Prevention for Abdominal Surgery-A Systematic
   Review and Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE general surgery; negative pressure wound therapy; surgical wound;
   surgical wound infection
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE
AB Open incision negative pressure wound therapy (NPWT) combines delayed closure with negative pressure to prevent surgical site infection (SSI). Its effectiveness in preventing SSI remains unclear, complicating its risk-benefit assessment. PubMed and Web of Science databases were searched for relevant English studies. Two reviewers independently screened titles and abstracts using the ASReviewer tool. Full-text articles were assessed for eligibility. Eight studies were included in the systematic review and five were pooled in the meta-analysis. Data extraction followed the PRISMA guidelines, and the risk of bias was assessed. A meta-analysis was performed using a random-effects model for SSI occurrence. Eight studies (three RCTs and five cohort studies) with 1655 patients were included. Studies were pooled based on control interventions: primary closure (PC) or delayed primary closure (DPC). Pooled odds ratio (OR) estimates favoured NPWT over PC for SSI reduction (OR, 0.15; 95% CI, 0.02-0.87). No significant SSI risk difference was found between the NPWT and DPC groups (OR, 0.28; 95% CI, 0.06-1.27). Preventive NPWT is associated with a reduced risk of SSI in abdominal surgery compared to PC. Our findings indicate that standardising treatment and reporting protocols could improve future evaluations of NPWT effectiveness.Trial Registration: PROSPERO identifier: CRD42024401669
C1 [Polomska, Katarzyna; Kowalik, Janina; Kobiela, Jarek; Spychalski, Piotr] Med Univ Gdansk, Dept Oncol Transplant & Gen Surg, Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Spychalski, P (通讯作者)，Med Univ Gdansk, Dept Oncol Transplant & Gen Surg, Gdansk, Poland.
EM piotr.spychalski@gumed.edu.pl
RI ; Spychalski, Piotr/KIG-0774-2024
OI Połomska, Katarzyna/0009-0005-1719-1215; 
CR Avsar P, 2021, WOUND MANAG PREV, V67, DOI 10.25270/wmp.2021.6.1019
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NR 31
TC 5
Z9 5
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70199
DI 10.1111/iwj.70199
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9828
UT WOS:001623084500001
PM 40234096
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shyu, YC
   Huang, TS
   Chiu, HS
   Sumazin, P
   Lin, XY
   Liao, PC
   Liou, CC
   Hsu, FC
   Lin, JS
   Hsu, CC
   Hsu, PH
   Sun, CC
   Chen, CT
AF Shyu, Yu-Chiau
   Huang, Ting-Shuo
   Chiu, Hua-Sheng
   Sumazin, Pavel
   Lin, Xin-Yu
   Liao, Po-Cheng
   Liou, Cai-Cin
   Hsu, Fang-Chia
   Lin, Jyuan-Siou
   Hsu, Chih-Chin
   Hsu, Pang-Hung
   Sun, Chi-Chin
   Chen, Chien-Tzung
TI Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound
   Therapy in a Murine Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE negative pressure wound therapy (NPWT); dickkopf-related-protein1
   (DKK-1); hair follicle stem cells (HFSCs); epidermal cells; inflammatory
ID HAIR FOLLICLE; GROWTH-FACTORS; SKIN; DIFFERENTIATION; PROLIFERATION;
   EXPRESSION; DRESSINGS; MIGRATION; REPAIR
AB Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NPWT C57BL/6JNarl mouse model to investigate the molecular mechanisms involved in NPWT. In this study, we investigate the intricate molecular mechanisms through which NPWT expedites wound healing. Our focus is on NPWT's modulation of inflammatory immune responses and the concurrent orchestration of multiple signal transduction pathways, resulting in shortened coagulation time and reduced inflammation. Notably, we observe a significant rise in dickkopf-related protein 1 (DKK-1) concentration during NPWT, promoting the differentiation of Hair Follicle Stem Cells (HFSCs) into epidermal cells, expediting wound closure. Under negative pressure, macrophages express and release DKK-1 cytokines, crucial for stimulating HFSC differentiation, as validated in animal experiments and in vitro studies. Our findings illuminate the inflammatory dynamics under NPWT, revealing potential signal transduction pathways. The proposed framework, involving early hemostasis, balanced inflammation, and macrophage-mediated DKK-1 induction, provides a novel perspective on enhancing wound healing during NPWT. Furthermore, these insights lay the groundwork for future pharmacological advancements in managing extensive wounds, opening avenues for targeted therapeutic interventions in wound care.
C1 [Shyu, Yu-Chiau; Lin, Xin-Yu; Liao, Po-Cheng; Liou, Cai-Cin; Hsu, Fang-Chia; Lin, Jyuan-Siou] Chang Gung Mem Hosp, Keelung Branch, Community Med Res Ctr, Keelung 204, Taiwan.
   [Shyu, Yu-Chiau] Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.
   [Huang, Ting-Shuo] Jen Ai Hosp, Dept Gen Surg, Taichung 400, Taiwan.
   [Huang, Ting-Shuo] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan 333, Taiwan.
   [Chiu, Hua-Sheng; Sumazin, Pavel] Texas Childrens Hosp Canc Ctr, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   [Hsu, Chih-Chin] Chang Gung Univ, Sch Med, Dept Med, Taoyuan 333, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung branch, Keelung 204, Taiwan.
   [Hsu, Pang-Hung] Natl Taiwan Ocean Univ, Dept Biosci & Biotechnol, Keelung 202, Taiwan.
   [Sun, Chi-Chin] Chang Gung Mem Hosp, Dept Ophthalmol, Keelung Branch, Keelung 204, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Linkou Branch, Taoyuan 333, Taiwan.
   [Chen, Chien-Tzung] Chang Gung Univ, Craniofacial Res Ctr, Taoyuan 333, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University of Science &
   Technology; Chang Gung University; Baylor College of Medicine; Chang
   Gung University; Chang Gung Memorial Hospital; National Taiwan Ocean
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University
RP Shyu, YC (通讯作者)，Chang Gung Mem Hosp, Keelung Branch, Community Med Res Ctr, Keelung 204, Taiwan.; Shyu, YC (通讯作者)，Chang Gung Univ Sci & Technol, Dept Nursing, Taoyuan 333, Taiwan.; Chen, CT (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Linkou Branch, Taoyuan 333, Taiwan.; Chen, CT (通讯作者)，Chang Gung Univ, Craniofacial Res Ctr, Taoyuan 333, Taiwan.
EM yuchiaushyu@cgmh.org.tw; huangts1234@gmail.com; hchiu@bcm.edu;
   sumazin@bcm.edu; love20070810@gmail.com; henryshome@gmail.com;
   nice302a@gmail.com; jasonsyu0131@gmail.com; 0117siou@gmail.com;
   steele0618@gmail.com; panghung.ntou@gmail.com; chichinsun@gmail.com;
   ctchenap@cgmh.org.tw
RI ; Sumazin, Pavel/AAE-6607-2020; Huang, Ting-Shuo/ABD-3205-2021; Hsu,
   Pang-Hung/C-5587-2018; Chiu, Hua-Sheng/I-7150-2019
OI Shyu, Yu-Chiau/0000-0003-1747-2226; Sumazin, Pavel/0000-0002-1215-4977;
   Hsu, Chih-Chin/0000-0002-5558-3456; Hsu, Pang-Hung/0000-0001-6873-6434;
   Chiu, Hua-Sheng/0000-0002-0296-5653; Lin, Xin-Yu/0000-0003-3311-1754
FU Keelung Chang Gung Memorial Hospital
FX We thank Ching-Wen Yang, Yu-Han Kuo, Rou-Ling Cho and Chun-Ju Yang for
   technical communication.
CR Adler Elizabeth M., 2007, Sci. STKE, V2007, ptw176
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NR 38
TC 3
Z9 4
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2024
VL 25
IS 4
AR 2373
DI 10.3390/ijms25042373
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JH8K4
UT WOS:001172363500001
PM 38397048
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kudou, M
   Morino, Y
   Matsuda, T
   Tarumto, K
   Yamazato, Y
   Hikami, S
   Tanaka, R
   Fukuda, K
   Yamamoto, Y
   Shimizu, Y
   Shiozaki, A
AF Kudou, Michihiro
   Morino, Yoshiki
   Matsuda, Tomoya
   Tarumto, Koji
   Yamazato, Yuzo
   Hikami, Shoichiro
   Tanaka, Ryoichi
   Fukuda, Kenichiro
   Yamamoto, Yoshiki
   Shimizu, Yoshihiro
   Shiozaki, Atsushi
TI Combined prophylactic negative-pressure wound therapy and preoperative
   oral antibiotics reduce perineal wound complications after
   abdominoperineal resection
SO SURGERY TODAY
LA English
DT Article
DE Rectal cancer; Abdominoperineal resection; Surgical site infection;
   Negative pressure wound therapy; Antibiotics
ID SURGICAL SITE INFECTION; CANCER SURGERY; POSTOPERATIVE COMPLICATIONS;
   PREVENTION; SURVIVAL; CLOSURE; IMPACT; COLON
AB Purpose Perineal wound complications after abdominoperineal resection (APR) remain a major concern, often leading to poor patient outcomes. Prophylactic negative-pressure wound therapy (pNPWT) and oral antibiotics (OA) administration have individually shown promise in reducing surgical site infections (SSIs). The present study investigated their combined effect for the prevention of perineal wound complications after APR. Methods This retrospective study included patients who underwent APR for lower rectal cancer between April 2016 and March 2025. Patients were divided into two groups: conventional treatment (CT) and those receiving a combination of pNPWT and preoperative OA (pNPWT + OA). Postoperative complications were compared. Results Sixteen patients were included in the pNPWT + OA group and 14 in the CT group. The incidence of superficial peri-neal SSIs was significantly lower in the pNPWT + OA group than in the CT group (6.3% vs. 42.9%, p = 0.030), with no cases of wound dehiscence (0% vs. 28.6%, p = 0.036). Furthermore, preoperative albumin < 3.0 g/dL correlated with the incidence of perineal SSIs and wound dehiscence. Conclusion The combined use of pNPWT and OA was associated with a reduction in perineal wound infections and dehis-cence following APR. This approach may improve postoperative outcomes; however, these findings are hypothesis-generat-ing and should be validated in large-scale, prospective studies, including cost-effectiveness analyses.
C1 [Kudou, Michihiro; Morino, Yoshiki; Yamazato, Yuzo; Hikami, Shoichiro; Fukuda, Kenichiro; Yamamoto, Yoshiki; Shimizu, Yoshihiro] Kyoto Okamoto Mem Hosp, Dept Digest Surg, Kyoto, Japan.
   [Kudou, Michihiro; Shiozaki, Atsushi] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan.
   [Matsuda, Tomoya; Tarumto, Koji; Tanaka, Ryoichi] Kyoto Okamoto Mem Hosp, Dept Surg, Kyoto, Japan.
C3 Kyoto Prefectural University of Medicine
RP Kudou, M (通讯作者)，Kyoto Okamoto Mem Hosp, Dept Digest Surg, Kyoto, Japan.; Kudou, M (通讯作者)，Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kyoto, Japan.
EM posit@koto.kpu-m.ac.jp
CR Aoyama T, 2017, CANCER MED-US, V6, P1573, DOI 10.1002/cam4.1126
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD JUL
PY 2026
VL 56
IS 7
BP 1184
EP 1190
DI 10.1007/s00595-025-03226-4
EA JAN 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KE8WX
UT WOS:001654947400001
PM 41495560
DA 2026-07-24
ER

PT J
AU Chen, H
   Xu, TJ
   Yu, H
   Zhu, JL
   Liu, Y
   Yang, LP
AF Chen, Hao
   Xu, Tong-Jie
   Yu, Hao
   Zhu, Jun-Long
   Liu, Yong
   Yang, Lu-Pin
TI 被撤回的出版物: Effect of platelet-rich plasma combined with negative pressure
   wound therapy in treating patients with chronic wounds: A meta-analysis
   (Retracted Article)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE chronic wounds; meta-analysis; negative pressure wound therapy;
   platelet-rich plasma; wound healing
ID ULCER
AB A meta-analysis was conducted to comprehensively explore the effects of platelet-rich plasma (PRP) combined with negative pressure wound therapy (NPWT) in treating patients with chronic wounds. Computer searches were conducted, from database infection to November 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the use of PRP combined with NPWT technology for treating chronic wounds. Two researchers independently screened the literature, extracted data and conducted quality assessments according to the inclusion and exclusion criteria. Stata 17.0 software was employed for data analysis. Overall, 18 RCTs involving 1294 patients with chronic wounds were included. The analysis revealed that, compared with NPWT alone, the use of PRP combined with NPWT technology significantly improved the healing rate (odds ratios [OR] = 1.92, 95% confidence intervals [CIs]: 1.43-2.58, p < 0.001) and total effective rate (OR = 1.31, 95% CI: 1.23-1.39, p < 0.001), and also significantly shortened the healing time of the wound (standardized mean difference = -2.01, 95% CI: -2.58 to -1.45, p < 0.001). This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.
C1 [Chen, Hao; Xu, Tong-Jie; Yu, Hao; Zhu, Jun-Long; Liu, Yong] Southwest Med Univ, Dept Vasc Surg, Affiliated Hosp, Luzhou, Peoples R China.
   [Yang, Lu-Pin] Southwest Med Univ, Dept Intervent Med, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China.
C3 Southwest Medical University; Southwest Medical University
RP Yang, LP (通讯作者)，Southwest Med Univ, Dept Intervent Med, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China.
EM luzyanglp646@sina.com
FU Scientific Research Project of Southwest Medical University
FX No Statement Availabler No Statement Available
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NR 48
TC 2
Z9 2
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2024
VL 21
IS 4
AR e14758
DI 10.1111/iwj.14758
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NW8E5
UT WOS:001203575400001
PM 38629618
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Veale, RWF
   Kollmetz, T
   Taghavi, N
   Duston-Fursman, CG
   Beeson, MT
   Asefi, D
   Chittock, HD
   Vikranth, AS
   Dowling, SG
   Dempsey, SG
   Rose, HJ
   Mason, ITT
   May, BCH
AF Veale, Robert W. F.
   Kollmetz, Tarek
   Taghavi, Navid
   Duston-Fursman, Claudia G.
   Beeson, Matthew T.
   Asefi, Dorrin
   Chittock, Henry D.
   Vikranth, Ananth S.
   Dowling, Shane G.
   Dempsey, Sandi G.
   Rose, Hamish J.
   Mason, Isaac T. T.
   May, Barnaby C. H.
TI Influence of advanced wound matrices on observed vacuum pressure during
   simulated negative pressure wound therapy
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
DE Ovine forestomach matrix; Negative pressure wound therapy; Collagen;
   ORC; Chronic wound; Dermal matrix
ID COLLAGEN EXTRACELLULAR-MATRIX; DIABETIC FOOT ULCER; ASSISTED CLOSURE;
   CLINICAL-OUTCOMES; IN-VITRO; MECHANISM; RECONSTRUCTION; ANGIOGENESIS;
   GROWTH; COST
AB Biomaterials and negative pressure wound therapy (NPWT) are treatment modalities regularly used together to accelerate soft-tissue regeneration. This study evaluated the impact of the design and composition of commer-cially available collagen-based matrices on the observed vacuum pressure delivered under NPWT using a custom test apparatus. Specifically, testing compared the effect of the commercial products; ovine forestomach matrix (OFM), collagen/oxidized regenerated cellulose (collagen/ORC) and a collagen-based dressing (CWD) on the observed vacuum pressure. OFM resulted in an-50% reduction in the observed target vacuum pressure at 75 mmHg and 125 mmHg, however, this effect was mitigated to a-0% reduction when fenestrations were intro-duced into the matrix. Both collagen/ORC and CWD reduced the observed vacuum pressure at 125 mmHg (-15% and-50%, respectively), and this was more dramatic when a lower vacuum pressure of 75 mmHg was delivered (-20% and-75%, respectively). The reduced performance of the reconstituted collagen products is thought to result from the gelling properties of these products that may cause occlusion of the delivered vacuum to the wound bed. These findings highlight the importance of in vitro testing to establish the impact of adjunctive therapies on NPWT, where effective delivery of vacuum pressure is paramount to the efficacy of this therapy.
C1 [Veale, Robert W. F.; Kollmetz, Tarek; Taghavi, Navid; Duston-Fursman, Claudia G.; Beeson, Matthew T.; Asefi, Dorrin; Chittock, Henry D.; Vikranth, Ananth S.; Dowling, Shane G.; Dempsey, Sandi G.; Rose, Hamish J.; Mason, Isaac T. T.; May, Barnaby C. H.] Aroa Biosurg Ltd, Auckland 2022, New Zealand.
RP May, BCH (通讯作者)，Aroa Biosurg Ltd, Auckland 2022, New Zealand.
EM Barnaby.May@aroabio.com
OI Veale, Robert/0000-0002-6534-0167; May, Barnaby/0000-0001-9855-018X;
   Dowling, Shane/0000-0002-7165-5560; Beeson, Matthew/0000-0001-5902-5120;
   Kollmetz, Tarek/0000-0003-4599-7935
FU Aroa Biosurgery Limited; Callaghan Innovation Limited (New Zealand)
   Growth Grant [MSMA1402]
FX This work was supported by Aroa Biosurgery Limited and Callaghan
   Innovation Limited (New Zealand) Growth Grant (MSMA1402).
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NR 54
TC 3
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD FEB
PY 2023
VL 138
AR 105620
DI 10.1016/j.jmbbm.2022.105620
EA DEC 2022
PG 8
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 7R2YF
UT WOS:000909942200001
PM 36543083
OA hybrid
DA 2026-07-24
ER

PT J
AU Gabriel, A
AF Gabriel, Allen
TI Integrated negative pressure wound therapy system with volumetric
   automated fluid instillation in wounds at risk for compromised healing
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE At-risk wounds; Infected wounds; Negative pressure wound therapy with
   instillation
ID CASE SERIES
AB Nearly all wounds are at risk for compromised healing due to excessive exudation, oedema, contaminants and presence of inflammatory mediators. Compromised wounds have the potential to develop complications, such as infection, which may lead to delayed wound healing, prolonged hospitalisation and more frequent readmissions. It is generally believed that the wound advances from contamination to colonisation when the bacteria on the wound's surface begin to replicate and increase their metabolic activity. Heavy bacterial bioburden increases the metabolic requirements, stimulates a proinflammatory environment and encourages the in-migration of monocytes, macrophages and leukocytes all of which can negatively impact wound healing. Bacteria also secrete harmful cytokines which can lead to vasoconstriction and decreased blood flow. Thus, controlling or preventing infections is essential for normal wound healing process to occur. While the mainstay of treating wound infection has historically included intravenous, oral and/or topical antimicrobials in addition to frequent gauze dressing changes, a shift towards wound management with advanced modalities, such as negative pressure wound therapy (NPWT), has occurred during the past decade. This review will provide expert opinion and scientific support for the use of NPWT with instillation (NPWTi; V.A.C. Instill (R) Wound Therapy and V.A.C. VeraFlo (TM) Therapy, KCI USA, Inc., San Antonio, TX) for the treatment of at-risk and complicated wounds.
C1 SW Med Grp Plast Surg, Dept Plast Surg, Vancouver, WA 98664 USA.
RP Gabriel, A (通讯作者)，SW Med Grp Plast Surg, Dept Plast Surg, 505 NE 87th Ave,Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI Gabriel, Allen/AFK-3548-2022
FU Kinetic Concepts, Inc.
FX Dr AG has a Consulting agreement with Kinetic Concepts, Inc. This
   article is part of an educational supplement funded by Kinetic Concepts,
   Inc. to provide an overview of the V.A.C.(R) Therapy family of products
   for new users in developing markets. Targeted for distribution at the
   2012 World Union of Wound Healing Societies (WUWHS) conference, this
   supplement article presents a brief literature review and clinical
   experience treating compromised wounds using V.A.C.(R) Therapy with
   instillation (i.e. VA.C. Instill (R) Wound Therapy and V.A.C. VeraFlo
   (TM) Therapy).
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NR 15
TC 30
Z9 34
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 25
EP 31
DI 10.1111/j.1742-481X.2012.01014.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000005
PM 22727137
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Montori, G
   Allievi, N
   Coccolini, F
   Solaini, L
   Campanati, L
   Ceresoli, M
   Fugazzola, P
   Manfredi, R
   Magnone, S
   Tomasoni, M
   Ansaloni, L
AF Montori, Giulia
   Allievi, Niccolo
   Coccolini, Federico
   Solaini, Leonardo
   Campanati, Luca
   Ceresoli, Marco
   Fugazzola, Paola
   Manfredi, Roberto
   Magnone, Stefano
   Tomasoni, Matteo
   Ansaloni, Luca
TI Negative Pressure Wound Therapy versus modified Barker Vacuum Pack as
   temporary abdominal closure technique for Open Abdomen management: a
   four-year experience
SO BMC SURGERY
LA English
DT Article
DE Temporary abdominal closure; Negative Pressure Wound Therapy; Barker
   Vacuum Pack; Open Abdomen; Trauma; Emergency surgery
AB Background: We reviewed our experience with patients presenting with trauma and peritonitis who underwent an open abdomen (OA) procedure, and compared outcomes between Negative Pressure Wound Therapy (NPWT) and a modified Barker Vacuum Pack (mBVP) technique.
   Methods: In this descriptive study, we retrospectively analyzed data regarding all patients who underwent OA for intra-abdominal sepsis or abdominal trauma at our Centre from January 2012 to December 2015. Demographic data, co-morbidities, indications to surgery, intra-operative details and Bjorck classification grade were considered. Outcomes included were: time to closure in days, fascial closure rates, ICU and hospital stay, in-hospital and overall mortality, and entero-atmospheric fistula rate.
   Results: A total of 83 cases were considered. Mean closure time was 6 days versus 6.5 days (p = 0.71) in NPWT and mBVP groups, respectively; the fascial closure rate was 75.4% versus 93.8% (p = 0.10). At multivariate analysis, in-hospital and overall mortality were significantly higher within the mBVP, as compared to NPWT (OR 3.8, 95% CI 1.1 to 13.1, p = 0.02 -OR 4.2, 95% CI 1.2 to 14.1, p = 0.01). Entero-atmospheric fistula rate was 2.6% in the two groups.
   Conclusions: NPWT as a temporary abdominal closure technique, as compared to mBVP, appears to be associated with better outcomes in terms of mortality.
C1 [Montori, Giulia; Allievi, Niccolo; Coccolini, Federico; Solaini, Leonardo; Campanati, Luca; Ceresoli, Marco; Fugazzola, Paola; Manfredi, Roberto; Magnone, Stefano; Tomasoni, Matteo; Ansaloni, Luca] Papa Giovanni XXIII Hosp, Unit Gen Surg, Pzza OMS 1, I-24127 Bergamo, Italy.
C3 ASST Papa Giovanni XXIII
RP Allievi, N (通讯作者)，Papa Giovanni XXIII Hosp, Unit Gen Surg, Pzza OMS 1, I-24127 Bergamo, Italy.
EM niccolo.allievi@gmail.com
RI Ansaloni, Luca/AAJ-6507-2020; Montori, Giulia/ABF-9661-2020; Coccolini,
   Federico/AAJ-6507-2020; Ceresoli, Marco/GMW-5356-2022; Fugazzola,
   Paola/AAH-4680-2019; Allievi, Niccolò/HPC-9638-2023; Magnone,
   Stefano/R-6719-2016; Tomasoni, Matteo/AAC-3732-2022; Ansaloni,
   Luca/AAP-9134-2020
OI Ansaloni, Luca/0000-0001-6427-0307; Montori, Giulia/0000-0002-7649-2174;
   Solaini, Leonardo/0000-0002-5031-9285; Coccolini,
   Federico/0000-0001-6364-4186; Ceresoli, Marco/0000-0001-7935-3842;
   Fugazzola, Paola/0000-0002-6227-9276; Magnone,
   Stefano/0000-0002-8001-3754; Ansaloni, Luca/0000-0001-6427-0307
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NR 20
TC 21
Z9 27
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUL 21
PY 2017
VL 17
AR 86
DI 10.1186/s12893-017-0281-3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FC4CW
UT WOS:000406787200001
PM 28732537
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lehrman, JD
AF Lehrman, Jeffrey D.
TI Combining the Benefits of Collagen and Negative Pressure Wound Therapy
   to Heal a Chronic Diabetic Foot Ulcer: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic foot ulcer; chronic wound; foot and ankle; negative pressure
   wound therapy; collagen
AB Introduction. Diabetes affects 30 million children and adults in the United States, equivalent to 1 out of every 11 people in the country, and results in costs of $327 billion annually. Interventions that can improve healing rates and/or reduce the size of diabetic ulcers may lower the incidence of infection, rate of amputations, and cost of care. This report is on the use of a collagen wound contact layer in conjunction with negative pressure wound therapy (NPWT) to achieve healing in a chronic diabetic foot ulcer (DFU). Case Report. A known patient with type 1 diabetes presented with a chronic DFU of 6 months' duration. Previous treatment modalities included offloading regimens and topical therapies (ie, clostridial collagenase, human platelet-derived growth factors, and 6 applications of a human amniotic membrane allograft). A collagen wound contact layer was applied to the debrided wound bed with subsequent debridements performed every other week, weekly NPWT dressing changes, and weekly contact layer changes. A 91% reduction in wound area was seen at day 35, with complete healing at day 63, and no recurrence at 18 months. Conclusions. The combination of a collagen wound contact layer and weekly NPWT had a significantly positive effect on healing in this chronic DFU. The regimen was well-tolerated and simple to administer in this case.
C1 [Lehrman, Jeffrey D.] Foot & Ankle Specialists Delaware Cty, Springfield, PA USA.
RP Lehrman, JD (通讯作者)，POB 270968, Ft Collins, CO 80527 USA.
EM jdlehrman@hotmail.com
CR [Anonymous], 2015, IDF Diabetes Atlas, V7
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   Yang WY, 2018, DIABETES CARE, V41, P917, DOI 10.2337/dci18-0007
NR 13
TC 7
Z9 8
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2020
VL 32
IS 3
BP E11
EP E13
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QJ6MA
UT WOS:000619801500001
PM 32335522
DA 2026-07-24
ER

PT J
AU Thorup, CB
   Hougaard, M
   Blindum, PF
   Sorensen, EE
AF Thorup, Charlotte B.
   Hougaard, Mette
   Blindum, Pernille F.
   Sorensen, Erik E.
TI Hospitalised patients' experiences during Negative Pressure Wound
   Therapy due to surgical site infection after vascular and cardiac
   surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; NPWT; patient experience; qualitative
   interview; surgical site infections
ID IMPACT; CARE; NPWT; PARTICIPATION; ALGINATE; CLOSURE; GROIN; PAIN
AB Surgical site infections that develop after vascular and cardiac surgery are often treated with Negative Pressure Wound Therapy (NPWT). Due to the severity of the infection and risk of bleeding, this NPWT often requires hospitalisation. Fourteen patients were selected for qualitative interviews to investigate their experiences and the meaning of patient participation during hospitalisation with NPWT. Results show that hospitalisation induces tension between an intrusion of privacy and being part of a community. Patients do not feel ill nor are considered ill. They feel minimised, lack participation and miss continuity, yet they still accept their circumstances by adjusting to hospital routines and treatment. The hospital's organisational framework compromises patient participation, yet patients still participate in supporting their own wound healing. They worry, are bored, lack a clear time horizon, and appear to be in an apathetic mood despite having significant time on their hands. In conclusion, the tension between a patient's privacy and sense of community, as well as involuntary participation in other patients' lives, compromises dignity and increases stress. Wound healing appears to be prolonged due to fasting, inactivity and stress. Self-reliant patients are at risk of being minimised and lack adequate emotional care, and the hospital's organisational framework hampers patient feelings of involvement and participation.
C1 [Thorup, Charlotte B.] Aalborg Univ Hosp, Dept Cardiothorac Surg, Aalborg, Denmark.
   [Thorup, Charlotte B.] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
   [Thorup, Charlotte B.; Sorensen, Erik E.] Aalborg Univ Hosp, Clincal Nursing Res Unit, Aalborg, Denmark.
   [Hougaard, Mette] Aalborg Univ Hosp, Dept Heart & Lung Surg, Aalborg, Denmark.
   [Blindum, Pernille F.] Aalborg Univ Hosp, Dept Vasc Surg, Aalborg, Denmark.
   [Sorensen, Erik E.] Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
C3 Aalborg University; Aalborg University Hospital; Aalborg University;
   Aalborg University Hospital; Aalborg University; Aalborg University
   Hospital; Aalborg University; Aalborg University Hospital; Aalborg
   University; Aalborg University Hospital; Aalborg University
RP Thorup, CB (通讯作者)，Aalborg Univ Hosp, Sondre Skovvej 5,3 Etage,Off 313, DK-9000 Aalborg, Denmark.
EM cbt@rn.dk
OI Thorup, Charlotte Brun/0000-0002-7519-2639
FU Department of cardiothoracic surgery at Aalborg University Hospital;
   Department of Valve Surgery at Aalborg University Hospital
FX The authors thank the Department of cardiothoracic surgery and
   Department of Valve Surgery at Aalborg University Hospital for
   supporting this research. The authors declare that they have no
   competing interests.
CR Abbotts Joanne, 2010, Br J Nurs, V19, pS37
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   WMA, 2013, WMA DECL HELS ETH PR
NR 36
TC 12
Z9 13
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2018
VL 15
IS 5
BP 707
EP 716
DI 10.1111/iwj.12913
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA GU0OU
UT WOS:000444951400004
PM 29927043
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Hyldig, N
   Möller, S
   Joergensen, JS
   Bille, C
AF Hyldig, Nana
   Moller, Soren
   Joergensen, Jan Stener
   Bille, Camilla
TI Clinical Evaluation of Scar Quality Following the Use of Prophylactic
   Negative Pressure Wound Therapy in Obese Women Undergoing Cesarean
   Delivery A Trial-Based Scar Evaluation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE cesarean delivery; incisional negative-pressure wound therapy; scar
   evaluation
AB Objective: To evaluate the cosmetic result of using incisional negative-pressure wound therapy (iNPWT) compared with standard postsurgical dressings in obese women undergoing cesarean delivery (CD).
   Methods: Postcesarean scars were objectively evaluated 6 and 12 months postsurgery by a plastic surgeon using the Manchester Scar Scale and the Stony Brook Scar Evaluation Scale. Subjective scar evaluation and health-related quality of life were assessed using the Patient Scar Assessment Scale and the EQ-5D-5L instrument, respectively. Main outcome measures were the cosmetic and functional outcome of treating a standardized surgical wound with iNPWT compared with standard dressings, changes in scar rating over time, and testing different scar scales for cosmetic evaluation.
   Results: The study found no difference in long-term cosmetic outcomes between iNPWTand standard dressings. The study demonstrated a statistically significant positive change in scar rating from surgery to 12 months postsurgery. A strong association was found between the scar scales with a high correlation between the objective scar scales (R approximately 0.80) and a moderate correlation between the subjective scale and each objective scale (R approximately 0.50).
   Conclusions: Prophylactic iNPWT has been found to reduce the risk of surgical site infection following CD. Conversely, this study was not able to detect a difference in the long-term cosmetic result after CD when compared with standard dressings.
C1 [Hyldig, Nana; Bille, Camilla] Univ Southern Denmark, Odense Univ Hosp, Inst Clin Res, Dept Plast Surg, Odense, Denmark.
   [Hyldig, Nana; Moller, Soren] Univ Southern Denmark, OPEN Open Patient Data Explorat Network, Odense Univ Hosp, Odense, Denmark.
   [Joergensen, Jan Stener] Univ Southern Denmark, Dept Obstet & Gynaecol, Odense Univ Hosp, Inst Clin Res, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital
RP Hyldig, N (通讯作者)，Odense Univ Hosp, JB Winslowsvej 9A,3th Floor, DK-5000 Odense C, Denmark.
EM nana.hyldig@rsyd.dk; Soren.Moller@rsyd.dk;
   Jan.Stener.Joergensen@rsyd.dk; camilla.bille@rsyd.dk
RI Hyldig, Nana/AAH-5220-2020; Möller, Sören/X-8738-2019
OI Hyldig, Nana/0000-0001-6758-6294; jørgensen, jan
   stener/0000-0001-5222-2535; Möller, Sören/0000-0003-0858-4269
FU iNPWT devicemanufacturer Smith Nephew
FX The substudy was funded by an unrestricted grant from the iNPWT
   devicemanufacturer Smith & Nephew. The company had no influence on study
   design, data collection, data analyses, interpretation of results, or in
   the writing of the report. Two of the authors have received funding or
   honoraria from the company Smith & Nephew (N.H., C.B.). The other
   authors have nothing to disclose.
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   Wu C., 2018, BJOG-INT J OBSTET GY, V3
NR 29
TC 4
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2020
VL 85
IS 6
BP E59
EP E65
DI 10.1097/SAP.0000000000002468
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PT6FJ
UT WOS:000608708900009
PM 32657852
OA hybrid
DA 2026-07-24
ER

PT J
AU Hill, R
AF Hill, Rosemary
TI Efficiency of New Smart Instillation Technology With Negative Pressure
   Wound Therapy in Managing Complex Chronic and Surgical Wounds: A Case
   Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE complex wound management; infected wounds; negative pressure wound
   therapy with instillation and dwell time; reticulated open cell foam
   dressing with through holes
ID RECOMMENDATIONS
AB Background. Use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) of a topical wound solution has been limited in some settings due to perceptions of setup complexity. Typically, some guesswork was needed to estimate an adequate volume of solution to instill without causing leaks. A novel smart technology is recently available in certain NPWTi-d systems that automatically estimates and instills a solution volume according to wound dimensions. Objective. To report experience with this smart instillation NPWTi-d system technology in managing 4 complex wounds containing large areas of devitalized tissue and/or yellow fibrinous slough. Materials and Methods. NPWTi-d was applied via a reticulated open cell foam dressing with through holes (ROCF-CC). The smart instill button was selected to automatically determine a volume of topical solution to instill, followed by a 10-minute dwell time and 2-hour cycle of -125 mm Hg negative pressure. Results. The average NPWTi-d duration was 17.0 days, and no air or solution leaks occurred during therapy. Dressings were changed 3 times per week. All wounds were converted to clean granulating wounds during therapy. Conclusion. In this case series, smart technology simplified setup and facilitated regular cleansing and removal of devitalized tissue through the ROCF-CC dressing.
C1 [Hill, Rosemary] Lions Gate Hosp, N Vancouver, BC, Canada.
RP Hill, R (通讯作者)，Vancouver Coastal Hlth, Lions Gate Hosp, 231 15th St E, N Vancouver, BC V7L 2L7, Canada.
EM Rosemary.hill@vch.ca
CR Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Kim PJ, 2023, WOUNDS, V35, pE82, DOI 10.25270/wnds/22029
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   McKanna M, 2016, OSTOMY WOUND MANAG, P3
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   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 7
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2024
VL 36
IS 11
BP 397
EP 401
DI 10.25270/wnds/24125
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA P9O6Z
UT WOS:001381115100007
PM 39666908
DA 2026-07-24
ER

PT J
AU Taeger, CD
   Wallner, S
   Martini, T
   Schiltz, D
   Kehrer, A
   Prantl, L
   Biermann, N
AF Taeger, Christian D.
   Wallner, Stefan
   Martini, Teresa
   Schiltz, Daniel
   Kehrer, Andreas
   Prantl, Lukas
   Biermann, Niklas
TI Analysis of Rinsing Fluid during Negative Pressure Wound Therapy with
   Instillation: A Potential Monitoring Tool in Acute and Chronic Wound
   Treatment. A Pilot Study
SO CELLS
LA English
DT Article
DE negative pressure wound therapy with instillation; wound healing;
   cytokines
AB Background: During negative pressure wound therapy (NPWT), open wounds are draped with a nontransparent sponge, making daily wound evaluation impossible. Sometimes, late or undetected bacterial infections and postoperative bleeding result in repetitive surgery, thus prolonging inpatient time. With the introduction of additional fluid instillation (NPWTi), the wound surface is rinsed, and bacteria, proteins and biomarkers are flushed into a collecting canister, which is later discarded. Methods: The aim of this pilot study was to analyze rinsing fluid samples (0.9% sodium chloride) from the NPWTi device in patients with acute and chronic wounds. In 31 consecutive patients a standardized laboratory analysis was performed to evaluate cellular composition and potassium, phosphate, lactate dehydrooxygenase, pH and total protein levels. Results: While there was an increase in the total cellular amount and the number of polymorphonuclear cells, the number of red blood cells (RBC) decreased after surgery. Potassium and pH showed no significant changes in the first three postoperative days, whereas total protein showed an undulant and partially significant course. Conclusion: We were able to quantify cellular metabolites by analyzing the rinsing fluid of NPWTi. We propose the analysis of this material as a novel and potentially promising tool to monitor wound status without removal of the dressing. The establishment of reference values might help to improve the NPWTi therapy.
C1 [Taeger, Christian D.; Martini, Teresa; Schiltz, Daniel; Kehrer, Andreas; Prantl, Lukas; Biermann, Niklas] Univ Hosp Regensburg, Ctr Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
   [Wallner, Stefan] Univ Hosp Regensburg, Inst Clin Chem, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Ctr Plast Hand & Reconstruct Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM christian.taeger@ukr.de; stefan.wallner@ukr.de;
   teresa.martini@stud.uni-regensburg.de; schiltz.da@gmail.com;
   andreaskehrer@gmx.de; lukas.prantl@ukr.de; niklas.biermann@ukr.de
RI ; Kehrer, Andreas/AAC-2483-2021; Schiltz, Daniel/HJP-4834-2023; prantl,
   Lukas/AAM-1848-2021
OI Wallner, Stefan/0000-0002-3365-9579; Kehrer,
   Andreas/0000-0001-9472-7662; Schiltz, Daniel/0000-0003-1096-9336;
   prantl, Lukas/0000-0003-2454-2499
FU Manfred Roth Stiftung
FX The Manfred Roth Stiftung funded this research. The funders had no role
   in the design of the study; in the collection, analyses, or
   interpretation of data; in the writing of the manuscript; or in the
   decision to publish the results.
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   Schreml S, 2010, J EUR ACAD DERMATOL, V24, P373, DOI 10.1111/j.1468-3083.2009.03413.x
   Schreml S, 2011, P NATL ACAD SCI USA, V108, P2432, DOI 10.1073/pnas.1006945108
   Singh D, 2019, PLAST RECONSTR SURG, V143, p11S, DOI 10.1097/PRS.0000000000005306
   Singh DP, 2019, PLAST RECONSTR SURG, V143, p41S, DOI 10.1097/PRS.0000000000005312
   Wilgus TA, 2013, ADV WOUND CARE, V2, P379, DOI 10.1089/wound.2012.0383
   Zhou SZ, 2019, PLAST RECONSTR SURG, V143, P468, DOI 10.1097/PRS.0000000000005274
NR 27
TC 6
Z9 6
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2021
VL 10
IS 4
AR 732
DI 10.3390/cells10040732
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RR1MZ
UT WOS:000642872200001
PM 33810232
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kanapathy, M
   Mantelakis, A
   Khan, N
   Younis, I
   Mosahebi, A
AF Kanapathy, Muholan
   Mantelakis, Angelos
   Khan, Natasha
   Younis, Ibby
   Mosahebi, Afshin
TI Clinical application and efficacy of negative pressure wound therapy
   with instillation and dwell time (NPWTi-d): A systematic review and
   meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE negative pressure wound therapy with instillation; NPWTi-d; Veraflo
ID SALINE
AB This study evaluates the current clinical evidence of Negative Pressure Wound Therapy with Instillation and dwell time (NPWTi-d) to establish its clinical application and efficacy. MEDLINE, EMBASE, and CENTRAL databases were searched from 1946 to July 2019 for studies reporting clinical outcomes on wounds treated with NPWTi-d. The primary outcome was proportion of wounds with complete healing. The secondary outcomes were mean time for healing, NPWTi-d settings, cost, length of stay, and adverse events. Thirteen articles were included with a total of 624 wounds in 542 patients involving wounds of various aetiology. The pooled proportion of wound that achieved complete healing was 93.65% (95%CI: 84.02-99.04). Normal saline was the most commonly used instillation solution with the mean dwell time of 14.23 minutes (95%CI: 10.88-17.59) and instillation cycle every 4.17 +/- 2.32 hourly. The mean therapy duration was 10.69 days (95%CI: 10.46-10.91) with daily cost of $194.80. The mean hospital stay was 18.1 days (95%CI: 17.20-19.00). There were no severe adverse effects reported. NPWTi-d is an adjuntive therapy to aid complete healing of the vast majority of wounds. However, the current data are limited by the lack of level 1 evidence.
C1 [Kanapathy, Muholan; Mosahebi, Afshin] UCL, Div Surg & Intervent Sci, London, England.
   [Kanapathy, Muholan; Younis, Ibby; Mosahebi, Afshin] Royal Free NHS Fdn Trust Hosp, Dept Plast & Reconstruct Surg, London, England.
   [Mantelakis, Angelos] Lewisham & Greenwich NHS Trust, Dept Ear Nose & Throat Surg, London, England.
   [Khan, Natasha] Imperial Coll Healthcare NHS Fdn Trust, Charing Cross Hosp, Dept Plast & Reconstruct Surg, London, England.
C3 University of London; University College London; Imperial College London
RP Mantelakis, A (通讯作者)，Lewisham & Greenwich NHS Trust, London SE13 6LH, England.
EM aggelosmantelakis@yahoo.com; ibbyyounis@hotmail.com
RI ; Kanapathy, Muholan/B-2225-2016
OI Mantelakis, Angelos/0000-0001-7109-943X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 24
TC 12
Z9 15
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1948
EP 1959
DI 10.1111/iwj.13487
EA OCT 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000574913400001
PM 33016602
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Dumville, JC
   Munson, C
   Christie, J
AF Dumville, Jo C.
   Munson, Christopher
   Christie, Janice
TI Negative pressure wound therapy for partial-thickness burns
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Negative-Pressure Wound Therapy; Wound Healing; Burns [pathology;
   therapy]; Randomized Controlled Trials as Topic; Suction
   [instrumentation; methods]; Humans
ID SUBATMOSPHERIC PRESSURE; PROGRESSION; PATIENT
AB Background
   A burn wound is a complex and evolving injury, with both local and systemic consequences. Burn treatments include a variety of dressings, as well as newer strategies, such as negative pressure wound therapy (NPWT), which, by means of a suction force that drains excess fluids from the burn, tries to promote the wound healing process and minimise progression of the burn wound.
   Objectives
   To assess the effectiveness of NPWT for people with partial-thickness burns.
   Search methods
   We searched the Cochrane Wounds Group Specialised Register (searched 04 September 2014); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 8).
   Selection criteria
   All randomised controlled trials (RCTs) and controlled clinical trials (CCTs) that evaluated the safety and effectiveness of NPWT for partial-thickness burns.
   Data collection and analysis Two review authors used standardised forms, and extracted the data independently. We assessed each trial for risk of bias, and resolved differences by discussion.
   Main results
   One RCT, that was an interim report, satisfied the inclusion criteria. We undertook a narrative synthesis of results, as the absence of data and poor reporting precluded us from carrying out any formal statistical analysis. The trial was at high risk of bias.
   Authors' conclusions
   There was not enough evidence available to permit any conclusions to be drawn regarding the use of NPWT for treatment of partial-thickness burn wounds.
C1 [Dumville, Jo C.; Christie, Janice] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Munson, Christopher] St Johns Hosp Howden, Dept Plast Surg, Livingston, Scotland.
C3 University of Manchester
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI Dumville, Jo/O-7867-2014; Christie, Janice/O-9320-2014
OI Dumville, Jo/0000-0002-6546-3685; Christie, Janice/0000-0001-6176-6075
FU National Institute for Health Research (NIHR)
FX External sources The National Institute for Health Research (NIHR) is
   the sole funder of the Cochrane Wounds Group, UK.
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
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NR 34
TC 35
Z9 41
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2014
IS 12
AR CD006215
DI 10.1002/14651858.CD006215.pub4
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AY5YZ
UT WOS:000347646300020
PM 25500895
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Niimi, Y
   Nakamoto, K
   Kamei, W
   Osa, N
   Hori, K
   Sakurai, H
AF Niimi, Yosuke
   Nakamoto, Kan
   Kamei, Wataru
   Osa, Nagisa
   Hori, Keijiro
   Sakurai, Hiroyuki
TI "Elephant-trunk" negative pressure wound therapy for fixing artificial
   dermis with basic fibroblast growth factor for critical limb ischemia
SO REGENERATIVE THERAPY
LA English
DT Article
DE Negative pressure wound therapy; NPWT; Critical limb ischemia; CLI;
   Peripheral arterial disease; Collagen-gelatin sponge
ID SUSTAINED-RELEASE; CLINICAL-TRIAL; SCAFFOLD
AB Introduction: The treatment of intractable toe ulcer with critical limb ischemia (CLI) is a challenge because of its poor blood flow and the wound. Here, a novel fixation technique for artificial dermis with negative pressure wound therapy (NPWT) was reported.
   Method: After the amputation of toe, artificial dermis made of collagen-gelatin sponge (CGS) was grafted onto the wound where human recombinant basic fibroblast growth factor (bFGF) was sprayed. The foot was put on adhesive iodine-impregnated drape, the artificial-dermis area was covered with a sponge dressing of which another end reached to the drape, and the vacuum port was applied on the dressing sponge sandwiched with two drapes and connected to an NPWT system. Since the shape of sponge-dressing was similar to that of elephant-trunk, the technique in this study was named an "Elephant-trunk" technique.
   Result: During NPWT period, no complications such as air leakage, skin erosion, ischemic around tissue were confirmed. The artificial dermis was engrafted completely at one week after surgery, and the wound was confirmed to close completely.
   Conclusion: This NPWT technique with bFGF and CGS accelerated the healing of wound treated conservatively with artificial dermis in CLI patients. (C) 2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
C1 [Niimi, Yosuke; Nakamoto, Kan; Kamei, Wataru; Osa, Nagisa; Hori, Keijiro; Sakurai, Hiroyuki] Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
C3 Tokyo Women's Medical University
RP Niimi, Y (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
EM niimi.yosuke@twmu.ac.jp; nakamoto.kan@twmu.ac.jp;
   kamei.wataru@twmu.ac.jp; osa.nagisa@twmu.ac.jp; hori.keijiro@twmu.ac.jp;
   sakurai.hiroyuki@twmu.ac.jp
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NR 23
TC 2
Z9 3
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3204
J9 REGEN THER
JI Regen. Ther.
PD DEC
PY 2021
VL 18
BP 316
EP 320
DI 10.1016/j.reth.2021.08.002
PG 5
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA WA7TW
UT WOS:000703088900040
PM 34522724
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU He, R
   Li, XY
   Xie, K
   Wen, B
   Qi, X
AF He, Rui
   Li, Xiangyan
   Xie, Kun
   Wen, Bing
   Qi, Xin
TI Characteristics of Fournier gangrene and evaluation of the effects of
   negative-pressure wound therapy
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Fournier gangrene; negative-pressure wound therapy; necrotizing
   fasciitis; microbiology; treatment
ID MORTALITY
AB Fournier gangrene (FG) is a life-threatening disease affecting the soft tissues of the genital, perineal, and perianal regions. This retrospective study aimed to summarize the characteristics of FG and evaluate the effects of negative-pressure wound therapy (NPWT). We analyzed clinical data of 36 patients with FG admitted to our department. Thirty-four cases had perianal and external genital infections, and the other two had secondary infection of the urinary fistula after trauma and retroperitoneal abscess, respectively. Monomicrobial, polymicrobial, culture-negative, and fungal infections were identified in 16, 17, 2, and 1 cases, respectively. Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Klebsiella pneumoniae, and Staphylococcus haemolyticus were the most common pathogens. The mortality rate was 8%. Twenty-seven and nine patients were treated with NPWT (group A) and conventional dressing (group B), respectively. The length of stay was 38.0 +/- 16.1 and 51.0 +/- 17.3 days, number of operations were 3 (3,6) and 13 (4,17), and wound healing times were 39.2 +/- 18.1 and 66.5 +/- 17.1 days in groups A and B, respectively. Taken together, clinicians should always consider the possibility of perianal or external genital infections progressing to FG in the daily work, especially for patients with diabetes mellitus. Enterobacteriaceae, Enterococcus, and Staphylococcus haemolyticus are the most common causative pathogens, and NPWT is an effective adjuvant therapy for wound management with fewer operations and a shorter wound healing time.
C1 [He, Rui; Xie, Kun; Wen, Bing; Qi, Xin] Peking Univ First Hosp, Dept Plast Surg & Burn, Beijing, Peoples R China.
   [Li, Xiangyan] Peking Univ First Hosp, Inst Clin Pharmacol, Dept Antiinfect, Beijing, Peoples R China.
RP Qi, X (通讯作者)，Peking Univ First Hosp, Dept Plast Surg & Burn, Beijing, Peoples R China.
EM 04983@pkufh.com
RI ; Qi, Xin/O-5922-2019
OI Kun, Xie/0009-0006-5903-619X; Qi, Xin/0000-0003-1124-2374
FU Youth Clinical Research Project of the Peking University First Hospital
   [2017CR13]
FX Funding This study was supported by the Youth Clinical Research Project
   of the Peking University First Hospital (grant no. 2017CR13).
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Yilmazlar T, 2017, INT J SURG, V40, P135, DOI 10.1016/j.ijsu.2017.02.067
NR 12
TC 5
Z9 6
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 6
PY 2023
VL 9
AR 1075968
DI 10.3389/fsurg.2022.1075968
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7X0GU
UT WOS:000913884100001
PM 36684293
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Agarwal, JP
   Ogilvie, M
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
   Song, DH
AF Agarwal, JP
   Ogilvie, M
   Wu, LC
   Lohman, RF
   Gottlieb, LJ
   Franczyk, M
   Song, DH
TI Vacuum-assisted closure for sternal wounds: A first-line therapeutic
   management approach
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS; FIXATION;
   SURGERY
AB Background: Vacuum-assisted closure therapy has gained widespread use since its introduction in 1997. Previous studies have attributed significant benefit to its use for treatment of sternal wounds with or without mediastinitis. Management of sternal wounds with this therapy has been shown to decrease the number of dressing changes, reduce the time between debridement and definitive closure, and reduce costs associated with a protracted course of in-hospital dressing changes. The therapy has been used both as a bridge between debridement and definitive closure and as a catalyst to secondary sternal-wound healing.
   Methods: The authors performed a retrospective review of 103 patients who underwent vacuum-assisted closure therapy after median sternotomy between June of 1999 and March of 2004 at a single institution. The wounds were classified as sterile wounds, superficial sternal infections, and mediastinitis. The wound closure device, consisting of a polyurethane sponge and evacuation tube with inline suction, was applied sterilely to A wounds over a layer of Acticoat.
   Results: Vacuum-assisted closure was utilized in the treatment of sternal wounds for 103 patients (67 male patients and 36 female patients) whose mean age was 52 years (range, 3 months to 91 years). Patient comorbidities included diabetes, chronic obstructive pulmonary disease, end-stage renal disease, immunosuppression, and others. Sixty-four percent of the patients had a diagnosis of mediastinitis; 36 percent had either superficial infections or a sterile wound. The therapy was utilized for an average period of 11 days per patient. Sixty-eight percent of the patients (70 of 103) had definitive chest closure with open reduction internal fixation and/or flap closure. The remaining 32 percent had no definitive closure method. The overall mortality rate was 28 percent (29 of 103 patients), although no deaths were directly related to use of the therapy, and only four deaths resulted from sepsis as a consequence of mediastinitis.
   Conclusions: The authors report the largest series of patients treated with this therapy for post-sternotomy sternal wounds and believe it is safe and effective as a first-line therapy in the management of sternal wounds. The mortality rate from their study represents the patients' underlying disease process and comorbidities and is not a reflection of complications associated with the therapy. Vacuum-assisted closure ther-apy has been shown to decrease wound edema, decrease the time to definitive closure, and reduce wound bacterial colony counts. The authors have implemented the therapy for most patients with sternal wounds/mediastinitis at their institution, and believe it should be a standard protocol in the first-line management of these types of wounds.
C1 Univ Chicago Hosp, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
   Univ Chicago Hosp, Dept Phys Therapy, Chicago, IL 60637 USA.
C3 University of Illinois System; University of Chicago; University of
   Chicago Medical Center; University of Illinois System; University of
   Chicago; University of Chicago Medical Center
RP Song, DH (通讯作者)，Univ Chicago Hosp, Plast & Reconstruct Surg Sect, 5841 S Maryland Ave,MC 6035, Chicago, IL 60637 USA.
EM dsong@surgery.bsd.uchicago.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 75
Z9 88
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP 15
PY 2005
VL 116
IS 4
BP 1035
EP 1040
DI 10.1097/01.prs.0000178401.52143.32
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 967TP
UT WOS:000232114400018
PM 16163091
DA 2026-07-24
ER

PT J
AU Kilbride, KE
   Cooney, DR
   Custer, MD
AF Kilbride, KE
   Cooney, DR
   Custer, MD
TI Vacuum-assisted closure: a new method for treating patients with giant
   omphalocete
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the American-Pediatric-Surgical-Association
CY MAY, 2005
CL Phoenix, AZ
SP Amer Pediat Surg Assoc
DE omphalocele; vacuum-assisted closure; giant omphalocele; wound VAC
ID EXTERNAL COMPRESSION; MANAGEMENT; SILON
AB Introduction: Closure of giant omphalocele can present a surgical challenge. Neither silo, skin flap, nor primary closure has been successful in treating all patients. We present a novel application of the vacuum-assisted closure (VAC) device, which allows for improved results in these difficult cases.
   Methods: The VAC device (KCI, San Antonio, Tex) consisted of a sponge applied directly to the bowel and liver, covered with impermeable transparent dressing, and attached to a low negative pressure system. The sponge was changed every 3 to 5 days under local sedation.
   Patients: All 3 patients had giant omphaloceles. The first infant, a 34 week gestational age (WGA) male, was initially treated with silo reduction, which disrupted after 21 days. The large mass of bowel and liver made primary closure impossible. The VAC was applied for 45 days. The viscera was easily reduced and subsequently covered with acellular dermal matrix (AlloDerm). The VAC was reapplied, and the small remaining defect was skin-grafted. The second male infant was a 34 WGA male infant who became septic after failure of prosthetic mesh closure. The VAC was applied for 22 days after removal of the mesh. The infection resolved, and the defect size was reduced, allowing for skin flap closure. Mesh infection and development of an enterocutaneous fistula in the last patient, a 37 WGA female child, were treated by mesh retrieval and application of the VAC for 36 days. The VAC allowed for control of the fistula output and development of a healthy granulation bed.
   Results: Vacuum-assisted closure was associated with (1) rapid shrinkage and reduction of the viscera (22-45 days); (2) cleansing of the wound; (3) excellent granulation; (4) maintenance of a sterile environment; and (5) ease of use, with changes possible at the bedside.
   Conclusion: The VAC device should be considered a safe and effective alternative in treating complicated cases of giant omphalocele until a more definitive closure method can be used. (c) 2006 Elsevier Inc. All rights reserved.
C1 Texas A&M Univ, Ctr Sci, Dept Surg, Div Pediat Surg, Temple, TX 76508 USA.
C3 Texas A&M University System
RP Custer, MD (通讯作者)，Childrens Hosp Scott & White Hosp, Temple, TX 76502 USA.
CR ALLEN RG, 1969, J PEDIATR SURG, V4, P3, DOI 10.1016/0022-3468(69)90177-8
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NR 9
TC 50
Z9 61
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0022-3468
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JAN
PY 2006
VL 41
IS 1
BP 212
EP 215
DI 10.1016/j.jpedsurg.2005.10.003
PG 4
WC Pediatrics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 010JZ
UT WOS:000235189400064
PM 16410135
DA 2026-07-24
ER

PT J
AU Yang, H
   Rui, YY
   Chen, H
AF Yang, Hui
   Rui, Yuanyi
   Chen, Hong
TI Management of a Pelvic Abscess and Abdominal Fistula after Palliative
   Total Pelvic Exenteration with Intraoperative Radiotherapy in Recurrent
   Rectal Cancer Without NPWT: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE fistula; intraoperative radiotherapy; negative-pressure wound therapy;
   pelvic abscess; pelvic exenteration; rectal cancer; wound care; wound
   dressing
ID PRESSURE WOUND THERAPY; INFECTION
AB A 59-year-old man with recurrent rectal cancer and type 2 diabetes mellitus underwent palliative total pelvic exenteration and intraoperative radiotherapy. After surgery, he experienced a pelvic abscess and abdominal-perineal fistula. Profuse exudate contaminated the midline abdominal incision through the abdominal-perineal fistula and delayed healing. Because of a residual tumor and the high cost, negative-pressure wound therapy was not performed. After 76 days of local treatment that involved removing necrotic tissue, controlling inflammation with an antimicrobial silver dressing, absorbing and draining exudate with a hypertonic saline dressing, promoting granulation and preventing infection with a silver alginate dressing, and promoting re-epithelialization with recombinant human epidermal growth factor gel, the abdominal wound and abdominal-perineal fistula healed successfully.
C1 [Yang, Hui; Chen, Hong] Sichuan Univ, West China Sch Nursing, Chengdu, Peoples R China.
   [Yang, Hui] Univ Elect Sci & Technol China, Gastrointestinal Surg Ctr, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr,Sch Med, Chengdu, Peoples R China.
   [Rui, Yuanyi] Univ Elect Sci & Technol China, Sch Med, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr, Chengdu, Peoples R China.
C3 Sichuan University; University of Electronic Science & Technology of
   China; University of Electronic Science & Technology of China
RP Yang, H (通讯作者)，Sichuan Univ, West China Sch Nursing, Chengdu, Peoples R China.; Yang, H (通讯作者)，Univ Elect Sci & Technol China, Gastrointestinal Surg Ctr, Sichuan Canc Hosp & Inst, Sichuan Canc Ctr,Sch Med, Chengdu, Peoples R China.
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NR 20
TC 3
Z9 3
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2021
VL 34
IS 12
BP 675
EP 679
DI 10.1097/01.ASW.0000797964.31949.b4
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA ZB2JJ
UT WOS:000756674400012
PM 34807899
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Saaiq, M
   Hameed-ud-Din
   Khan, MI
   Chaudhery, SM
AF Saaiq, Muhammad
   Hameed-ud-Din
   Khan, Muhammad Ibrahim
   Chaudhery, Saud Majid
TI Vacuum-Assisted Closure Therapy as A Pretreatment For Split Thickness
   Skin Grafts
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Open wound; Wound bed preparation; Vacuum assisted closure therapy;
   Vacuum-assisted closure dressing; Split thickness skin graft; Graft take
ID PRESSURE WOUND THERAPY; MANAGEMENT; INJURY
AB Objective. To evaluate the effect of vacuum-assisted closure (VAC) therapy on wound management by measuring the graft take, wound healing time, need for any re-grafting and duration of hospitalization
   Study Design: Single blinded randomized controlled trial.
   Place and Duration of Study This study was carried out in the Department of Plastic and Reconstructive Surgery, Pakistan Institute of Medical Sciences (PIMS), Islamabad, from October 2007 to December 2009
   Methodology: A total of 100 adult patients of either gender with acute traumatic wounds were included. Patients who needed flap coverage as the primary intervention, and those with Diabetes, malignancy, bleeding diathesis were excluded. Half of the patients were randomly assigned to the intervention group and the rest to the control group with lottery method. All wounds were initially subjected to thorough excision Wound bed preparation for STSG (split thickness skin graft) was achieved using 10 days pre-treatment with VAC dressings in the intervention group while employing normal saline gauzes in the control group All patients were subsequently treated with STSG. The primary outcome measure was graft take while the secondary outcome measures included wound healing time, need for any re-grafting and duration of hospital stay Results were compared in both groups using chi-square test.
   Results: Marked differences were found in favour of the VAC therapy group with respect to the various wound management outcome measures studied. i.e. graft take (greater than 95% graft take in 90% of VAC therapy group vs. 18% of controls), wound healing time (2 weeks postgrafting in 90% of VAC therapy group vs. 18% of controls), need for regrafting (none among VAC therapy group vs. 8% of controls) and duration of hospital stay (less than 3 weeks in 90% of VAC therapy group vs. 18% of controls)
   Conclusion: VAC therapy should be employed in the pre-treatment of wounds planned to be reconstructed with STSG, since it has marked advantages in the wound bed preparation compared with the traditional normal saline gauze dressings.
C1 [Saaiq, Muhammad; Hameed-ud-Din; Khan, Muhammad Ibrahim; Chaudhery, Saud Majid] MOs Hosp, PIMS, Dept Plast Surg, Islamabad, Pakistan.
RP Saaiq, M (通讯作者)，MOs Hosp, PIMS, Dept Plast Surg, Room 20, Islamabad, Pakistan.
RI Saaiq, Muhammad/Q-8931-2018
OI Saaiq, Muhammad/0000-0003-1714-0491
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NR 27
TC 34
Z9 40
U1 0
U2 1
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD OCT
PY 2010
VL 20
IS 10
BP 675
EP 679
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 661KZ
UT WOS:000282728500010
PM 20943111
DA 2026-07-24
ER

PT J
AU Xu, BH
   Song, X
   Weng, YJ
AF Xu, Beihua
   Song, Xia
   Weng, Yajuan
TI A Multidisciplinary Team Approach for Diabetic Foot Ulcer: A Case Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE diabetic foot ulcer; education; interprofessional; local wound care;
   multidisciplinary; negative-pressure wound therapy
ID MANAGEMENT
AB A multidisciplinary team (MDT) approach is the most efficient way to treat many chronic and serious diseases. In this case report, providers sought to implement an MDT approach to treat a patient with diabetes and foot ulcers, actively involving the patient's caregiving family members. Comprehensive evaluation, blood sugar control, and timely referral were established as the primary treatment course. Negative-pressure wound therapy was applied to completely remove necrotic tissue debris and seropurulent discharge from the foot ulcers under the consultation of the MDT team. Local wound management, protection of the periwound skin, and health education for the patient's wound care nurse specialists were integral to the treatment outcome. After 3 months of treatment, the patient's right foot wound bed was improved, and further skin-grafting surgery was performed to accelerate the healing process during follow-up treatments.
C1 [Xu, Beihua; Song, Xia] Wound Care Clin, Affiliated Hosp Soochow 3, Changzhou, Peoples R China.
   [Weng, Yajuan] Nanjing Drum Tower Hosp, Chair Wound Ostomy Continence Nursing Grp, Nanjing, Peoples R China.
C3 Nanjing University
RP Xu, BH (通讯作者)，Wound Care Clin, Affiliated Hosp Soochow 3, Changzhou, Peoples R China.
CR Armstrong David G, 2011, J Diabetes Sci Technol, V5, P1591
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   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
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NR 14
TC 9
Z9 10
U1 4
U2 45
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2023
VL 36
IS 4
BP 6
EP 6
DI 10.1097/01.ASW.0000920512.88426.90
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA A6KE5
UT WOS:000956182300004
PM 36940382
DA 2026-07-24
ER

PT J
AU Martynov, I
   Gosemann, JH
   Hofmann, AD
   Kuebler, JF
   Madadi-Sanjani, O
   Ure, BM
   Lacher, M
AF Martynov, Illya
   Gosemann, Jan-Hendrik
   Hofmann, Alejandro D.
   Kuebler, Joachim F.
   Madadi-Sanjani, Omid
   Ure, Benno M.
   Lacher, Martin
TI Vacuum-assisted closure (VAC) prevents wound dehiscence following
   posterior sagittal anorectoplasty (PSARP): An exploratory case-control
   study
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Anorectal malformations; Posterior sagittal anorectoplasty; Wound
   dehiscence; Vacuum-assisted closure
ID ANORECTAL-MALFORMATIONS; MANAGEMENT; COLOSTOMY; REPAIR; ARM
AB Background: Wound dehiscence (WD) of the anocutaneous anastomosis or perineal body after posterior sagittal anorectoplasty (PSARP) is common. We aimed to evaluate the efficacy of a perineal vacuum-assisted closure (VAC) for prevention of WD following repair of anorectal malformations (ARM) with rectoperineal and rectovestibular fistula.
   Methods: A retrospective dual-center case-control study of children undergoing PSARP without colostomy between 2011 and 2019 was performed. The VAC group received preoperative bowel preparation (PBP), postoperative appli-cation of a VAC, loperamide (only Location A), intravenous antibiotics (IA), and total parenteral nutrition (TPN). The non-VAC group underwent PBP, loperamide (Location A), IA, and TPN without VAC. Primary outcome was WD at the anocutaneous anastomosis or reconstructed perineal body within the first 14 days after surgery.
   Results: The study population included 18 patients (VAC group) and 20 children (non-VAG group) with rectoperineal and rectovestibular fistula. The incidence of WD in the VAC group was 0% compared to 25% in the non-VAC group (0/18 vs. 5/20, p = 0.04). No VAC related complications occurred.
   Conclusion: Postoperative application of a VAC embedded in a perioperative treatment protocol has the potential to prevent wound dehiscence of the neoanus and reconstructed perineal body following PSARP.
   Type of study: Case-control study. Level of evidence: Level III.
   (c) 2020 Elsevier Inc. All rights reserved.
C1 [Martynov, Illya; Gosemann, Jan-Hendrik; Lacher, Martin] Univ Leipzig, Dept Pediat Surg, Liebigstr 20 a, D-04103 Leipzig, Germany.
   [Hofmann, Alejandro D.; Kuebler, Joachim F.; Madadi-Sanjani, Omid; Ure, Benno M.] Hannover Med Sch, Dept Pediat Surg, Hannover, Germany.
C3 Leipzig University; Hannover Medical School
RP Martynov, I (通讯作者)，Univ Leipzig, Dept Pediat Surg, Liebigstr 20 a, D-04103 Leipzig, Germany.
EM Illya.Martynov@medizin.uni-leipzig.de
RI /AAS-1006-2020
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NR 32
TC 8
Z9 9
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD APR
PY 2021
VL 56
IS 4
BP 745
EP 749
DI 10.1016/j.jpedsurg.2020.07.009
EA MAY 2021
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA SA9PQ
UT WOS:000649635500020
PM 32778448
DA 2026-07-24
ER

PT J
AU Jiang, MX
   Liang, WG
   Chen, XP
   Ge, YL
   Fang, YY
   Zhang, HT
   Jiang, RR
   Luo, BJ
AF Jiang, Mengxiao
   Liang, Wenguang
   Chen, Xiaoping
   Ge, Yonglan
   Fang, Yanyan
   Zhang, Huiting
   Jiang, Rongrong
   Luo, Baojia
TI Effective management of cervical anastomotic leakage post-esophageal
   cancer surgery using negative pressure wound therapy with saline
   instillation: A case report
SO ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE Esophageal cancer; Anastomotic leakage; Negative pressure with
   instillation; Wound therapy
AB Cervical anastomotic leakage (AL) is a severe complication following esophageal cancer surgery, leading to significant morbidity and risk of mortality. This case report describes the successful application of negative pressure wound therapy with instillation (NPWTi) in managing AL after esophageal surgery. A 61-year-old patient developed an anastomotic leak on postoperative day 7, accompanied by persistent neck pain and leakage of nutritional fluids. Treatment involved a dual-tube NPWTi system with continuous saline instillation to clean and prevent infection, maintain wound moisture, and promote tissue granulation. Within 15 days, the leakage was substantially controlled, and a barium swallow test confirmed complete closure by day 20. This case suggests NPWTi as a promising and less invasive approach to managing AL post-esophagectomy, warranting further research on its clinical efficacy and safety.
C1 [Jiang, Mengxiao; Chen, Xiaoping; Ge, Yonglan; Fang, Yanyan; Zhang, Huiting; Jiang, Rongrong; Luo, Baojia] Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Nursing Dept, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China.
   [Liang, Wenguang] Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen
   University
RP Zhang, HT; Jiang, RR; Luo, BJ (通讯作者)，Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Canc, Nursing Dept, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China.
EM Zhanght@sysucc.org.cn; Jiangrr@sysucc.org.cn; luobj@sysucc.org.cn
RI Chen, Xiaoping/NQF-2525-2025; Zhang, Huiting/IQW-3491-2023
OI Chen, Xiaoping/0009-0002-3306-2913; 
CR Afzal H, 2024, SURG INFECT, V25, P199, DOI 10.1089/sur.2023.299
   Ascari F, 2024, J GASTROINTEST SURG, V28, P1072, DOI 10.1016/j.gassur.2024.04.024
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   De Pellegrin L, 2023, INT WOUND J, V20, P2402, DOI 10.1111/iwj.14072
   Fabbi M, 2021, DIS ESOPHAGUS, V34, DOI 10.1093/dote/doaa039
   Fernández LG, 2024, ADV WOUND CARE, V13, P416, DOI 10.1089/wound.2023.0113
   Fujisawa K, 2024, LARYNGOSCOPE, V134, P4573, DOI 10.1002/lary.31549
   Han BF, 2024, J NATL CANCER CTR, V4, P47, DOI 10.1016/j.jncc.2024.01.006
   Hauge T, 2024, DIS ESOPHAGUS, V37, DOI 10.1093/dote/doae040
   Hauge T, 2020, ACTA ONCOL, V59, P859, DOI 10.1080/0284186X.2020.1750694
   Jezerskyte E, 2021, ANN SURG ONCOL, V28, P7259, DOI 10.1245/s10434-021-10144-5
   Kamarajah SK, 2024, BEST PRACT RES CL GA, V70, DOI 10.1016/j.bpg.2024.101916
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Lange J, 2023, SURG ENDOSC, V37, P3657, DOI 10.1007/s00464-023-09861-7
   Leow Kimberley, 2020, Wounds, V32, pE120
   Li YH, 2020, J INT MED RES, V48, DOI 10.1177/0300060520926025
   Lin XH, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14727
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   Schuring N, 2023, EJSO-EUR J SURG ONC, V49, P97, DOI 10.1016/j.ejso.2022.07.020
   Seo HW, 2024, J CHEST SURG, V57, P152, DOI 10.5090/jcs.23.114
   Silverman Ronald P, 2023, Eplasty, V23, pe54
   Singh PK, 2023, LANGENBECK ARCH SURG, V409, DOI 10.1007/s00423-023-03202-x
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   van Geffen EGM, 2024, DIS ESOPHAGUS, V37, DOI 10.1093/dote/doae059
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   Zheng B, 2022, TRANSL LUNG CANCER R, V11, P331, DOI 10.21037/tlcr-22-141
NR 36
TC 0
Z9 0
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2347-5625
EI 2349-6673
J9 ASIA-PAC J ONCOL NUR
JI Asia-Pac. J. Oncol. Nurs.
PD DEC
PY 2025
VL 12
AR 100623
DI 10.1016/j.apjon.2024.100623
EA DEC 2024
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA P4T9K
UT WOS:001377862500001
PM 39717627
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gillespie, BM
   Webster, J
   Ellwood, D
   Thalib, L
   Whitty, JA
   Mahomed, K
   Clifton, V
   Kumar, S
   Wagner, A
   Kang, E
   Chaboyer, W
AF Gillespie, Brigid M.
   Webster, Joan
   Ellwood, David
   Thalib, Lukman
   Whitty, Jennifer A.
   Mahomed, Kassam
   Clifton, Vicki
   Kumar, Sailesh
   Wagner, Adam
   Kang, Evelyn
   Chaboyer, Wendy
TI Closed incision negative pressure wound therapy versus standard
   dressings in obese women undergoing caesarean section: multicentre
   parallel group randomised controlled trial
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID SURGICAL SITE INFECTION
AB OBJECTIVE To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with standard dressings in preventing surgical site infection (SSI) in obese women undergoing caesarean section. DESIGN Multicentre, pragmatic, randomised, controlled, parallel group, superiority trial. SETTING Four Australian tertiary hospitals between October 2015 and November 2019. PARTICIPANTS Eligible women had a pre-pregnancy body mass index of 30 or greater and gave birth by elective or semi-urgent caesarean section. INTERVENTION 2035 consenting women were randomised before the caesarean procedure to closed incision NPWT (n=1017) or standard dressing (n=1018). Allocation was concealed until skin closure. MAIN OUTCOME MEASURES The primary outcome was cumulative incidence of SSI. Secondary outcomes included depth of SSI (superficial, deep, or organ/body space), rates of wound complications (dehiscence, haematoma, seroma, bleeding, bruising), length of stay in hospital,
C1 [Gillespie, Brigid M.; Kang, Evelyn; Chaboyer, Wendy] Griffith Univ, Menzies Hlth Inst, Ctr Res Excellence Wiser Wound Care, Natl Hlth & Med Res Council, Gold Coast, Qld, Australia.
   [Gillespie, Brigid M.; Ellwood, David] Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
   [Webster, Joan] Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Herston, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia.
   [Thalib, Lukman] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Qld, Australia.
   [Whitty, Jennifer A.; Kang, Evelyn] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
   [Whitty, Jennifer A.; Wagner, Adam] Natl Inst Hlth Res, Appl Res Collaborat ARC, East England EoE, Norwich, Norfolk, England.
   [Mahomed, Kassam] Ipswich Hosp, West Moreton Hlth, Ipswich, Qld, Australia.
   [Clifton, Vicki; Kumar, Sailesh] Univ Queensland, Mater Res Inst, South Brisbane, Qld, Australia.
   [Kumar, Sailesh] Mater Mothers Hosp, South Brisbane, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Gold Coast
   Health; Gold Coast University Hospital; Royal Brisbane & Women's
   Hospital; Griffith University; Griffith University; University of East
   Anglia; University of Queensland; Mater Research; Mater Health Services;
   Mater Mothers' Hospital
RP Gillespie, BM (通讯作者)，Griffith Univ, Menzies Hlth Inst, Ctr Res Excellence Wiser Wound Care, Natl Hlth & Med Res Council, Gold Coast, Qld, Australia.; Gillespie, BM (通讯作者)，Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
EM b.gillespie@griffith.edu.au
RI Whitty, Jennifer/N-6434-2013; Thalib, Lukman/HAI-7553-2022; Chaboyer,
   Wendy/F-9588-2018; Ellwood, David/C-8208-2015; Mahomed,
   Kassam/M-1335-2013; Wagner, Adam/AAA-4346-2019; Gillespie,
   Brigid/E-7799-2012; Clifton, Vicki L/AAV-2749-2021
OI Thalib, Lukman/0000-0002-1211-6495; Chaboyer, Wendy/0000-0001-9528-7814;
   Ellwood, David/0000-0003-4512-6443; Wagner, Adam/0000-0002-9101-3477;
   Gillespie, Brigid/0000-0003-3186-5691; Kang, Evelyn/0000-0001-8253-1638;
   Clifton, Vicki L/0000-0002-4892-6748
FU Australian National Health and Medical Research Council [APP1081026]
FX The trial was funded by a competitive peer reviewed grant (APP1081026)
   from the Australian National Health and Medical Research Council. The
   funders had no role in considering the study design or in the
   collection, analysis, or interpretation of data, the writing of the
   report, or the decision to submit the article for publication. The views
   expressed are those of the authors and not necessarily those of the NHS,
   the National Institute for Health Research (NIHR) , or the Department of
   Health and Social Care.
CR Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
   Bestgen Y, 2021, PROCEEDINGS OF THE WORKSHOP ON COGNITIVE MODELING AND COMPUTATIONAL LINGUISTICS, P90, DOI [10.21474/ijar01/10949, 10.11122/ijmeb.2014.15.4.2594, 10.37200/ijpr/v24i5/pr2020764, 10.20546/ijcmas.2019.809.187, 10.26452/ijrps.v11i2.1997, 10.15503/onis2019.189.198, 10.70933/2773-9465.1801, 10.1016/j.vhri.2020.07.329, 10.3126/jpahs.v7i1.28858, 10.30534/ijatcse/2020/123922020, 10.24290/1029-3736-2019-25-1-62-77, 10.4236/jbm.2020.89008, 10.1589/rika.34.839, 10.19107/ijisc.2019.02.01, 10.36939/cjur/vol29no1/art269, 10.4103/phmj.phmj_14_20, 10.1038/s41598-022-19167-8]
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   Ferraro F, 2016, NEW MICROBIOL, V39, P134
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   Gillespie BM, 2015, SURG INNOV, V22, P488, DOI 10.1177/1553350615573583
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   Ramírez-Wong FM, 2015, SURG INFECT, V16, P572, DOI 10.1089/sur.2014.201
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   Yang XJ, 2017, ARCH GYNECOL OBSTET, V296, P503, DOI 10.1007/s00404-017-4445-2
NR 29
TC 32
Z9 36
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD MAY 5
PY 2021
VL 373
AR bmj
DI 10.1136/bmj.n893
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SD2YX
UT WOS:000651241900014
PM 33952438
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Maguire, CR
   Livingston, R
   Phillips, GE
   Kimble, RM
AF Maguire, Christopher R.
   Livingston, Ryan
   Phillips, Gael E.
   Kimble, Roy M.
TI Giant congenital melanocytic nevi and malignant transformation: a case
   for early radical intervention
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Congenital melanocytic nevus; Integra; Negative pressure wound therapy;
   Malignant transformation
ID MELANOMA; CLOSURE; RISK
AB The purpose of this paper is to highlight the risk of early malignant transformation in infants with giant congenital melanocytic nevi (GN) and demonstrate the potential for earlier intervention with aggressive surgery. We describe the case of a child born with a GN who developed a metastatic melanoma early in life, despite early commencement of resection of the nevus. This is contrasted against a second case of a child in which a more radical management was conducted. Despite early commencement of serial resection of the GN, the first child in this series died of metastatic melanoma prior to complete excision of the nevus. With the second child, radical excision combined with the use of Integra (TM) and negative pressure wound therapy allowed total removal of the GN within the first 6 months of life.
C1 [Maguire, Christopher R.] Mater Hosp, Brisbane, Qld, Australia.
   [Livingston, Ryan] Princess Alexandra Hosp, Brisbane, Qld, Australia.
   [Phillips, Gael E.] CCHR, Cent Lab Herston, Pathol Queensland, Brisbane, Qld, Australia.
   [Kimble, Roy M.] Lady Cilento Childrens Hosp, Ctr Childrens Burns & Trauma Res, Brisbane, Qld, Australia.
C3 Mater Health Services; Mater Hospital Brisbane; Princess Alexandra
   Hospital; Childrens Health Queensland Hospital & Health Service;
   Queensland Childrens Hospital
RP Maguire, CR (通讯作者)，Mater Hosp, Brisbane, Qld, Australia.
EM christopher.r.maguire@gmail.com; Drryanlivingston@hotmail.co.uk;
   gael.phillips@health.qld.gov.au; royk@uq.edu.au
RI ; Kimble, Roy/B-4160-2011
OI Maguire, Christopher/0000-0002-4179-2089; 
CR Abadi B, 2004, PLAST RECONSTR SURG, V114, P162
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 11
TC 6
Z9 7
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD JUL
PY 2017
VL 33
IS 7
BP 823
EP 827
DI 10.1007/s00383-017-4095-2
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA EY8IQ
UT WOS:000404238600014
PM 28508099
DA 2026-07-24
ER

PT J
AU Li, Z
   Wu, JW
   Zhang, HW
   Topaz, M
   He, F
AF Li, Zhen
   Wu, Jiang-Wen
   Zhang, Hong-Wei
   Topaz, Moris
   He, Fang
TI 被撤回的出版物: Regulated negative pressure wound therapy combined TopClosure®
   in treatment of skin defect for open fracture in lower extremity: a case
   report (Retracted article. See vol. 11, pg. 6383, 2018)
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article; Retracted Publication
DE Regulated negative pressure wound therapy; Top Closure; open fracture;
   skin defect; treatment
ID VISCOELASTIC PROPERTIES; MANAGEMENT; CLOSURE; INJURY
AB Open fracture in lower extremity is the common trauma. However, some of the wound may easily developed into the skin defect. Regulated negative pressure-assisted wound therapy (RNPT) has been widely used to treat infected wounds and chronic wounds that may decrease bacterial load and promotion of wound healing. TopClosure (R) was used to as an innovative skin extension and wound closure-secure system that reducing tension across wound edges. In this case, RNPT combined with TopClosure (R) were employed to treat the skin defect in lower extremity, which may aid immediate wound closure and downgrade treatment time and the dress changing frequency for a wide range of applications on a global scle.
C1 [Li, Zhen; He, Fang] Shihezi Univ, Coll Med, Minist Xinjiang Endem & Ethn Dis, Dept Pathophysiol,Key Lab Educ, Shihezi, Peoples R China.
   [Li, Zhen] Shihezi Univ, Affiliated Hosp 1, Dept Emergency & Crit Care Med, Shihezi, Peoples R China.
   [Wu, Jiang-Wen; Zhang, Hong-Wei] Shihezi Univ, Affiliated Hosp 1, Dept Gen Surg, Shihezi, Peoples R China.
   [Topaz, Moris] Hillel Yaffe Med Ctr, Plast Surg Unit, Hadera, Israel.
C3 Shihezi University; Shihezi University; Shihezi University
RP He, F (通讯作者)，Shihezi Univ, Coll Med, Minist Xinjiang Endem & Ethn Dis, Dept Pathophysiol,Key Lab Educ, Shihezi, Peoples R China.
EM fangf2002shz@126.com
CR Abramson DL, 1997, ANN PLAS SURG, V38, P540, DOI 10.1097/00000637-199705000-00019
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NR 20
TC 1
Z9 1
U1 0
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 8
BP 12659
EP 12662
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF1EX
UT WOS:000408643700165
DA 2026-07-24
ER

PT J
AU Poulakidas, SJ
   Kowal-Vern, A
   Atty, C
AF Poulakidas, Stathis J.
   Kowal-Vern, Areta
   Atty, Corinne
TI Pediatric Frostbite Treated by Negative Pressure Wound Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID INJURIES; CHILDHOOD; TISSUE
AB Frostbite injury in children can lead to abnormal growth and premature fusion of the epiphyseal cartilage with long-term sequela including, but not limited to, arthroses, deformity, and amputation of the phalanges. This was a retrospective chart review of pediatric frostbite identified in an in-house burn center registry from March 1999 to March 2014. Therapeutic management included negative pressure wound therapy (NPWT). Three patients (age 16-31 months) had frostbitten hands because they were outside in cold weather without gloves. They presented within 24 hours after injury, underwent 5-6 days of NPWT after excision of blisters, and did not lose the distal portion of their digits, or require amputations. On follow-up, all hands were healed well with only minimal or no effect on the growth plate of these pediatric patients. In the early period after frostbite, NPWT may be beneficial in preserving the epiphyseal cartilage in children and preventing long-term complications.
C1 [Poulakidas, Stathis J.] John H Stroger Jr Hosp Cook Cty, Sumner L Koch Burn Ctr, Chicago, IL USA.
   [Poulakidas, Stathis J.; Kowal-Vern, Areta] Rush Univ, Dept Surg, Chicago, IL 60612 USA.
   [Atty, Corinne] Northwestern Univ, Med Ctr, Dept Radiol, Chicago, IL 60611 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; John H Stroger Junior Hospital
   Cook County; Rush University; Northwestern University
RP Kowal-Vern, A (通讯作者)，Rush Univ, Med Ctr, Dept Gen Surg, Div Colorectal Surg, Rush Profess Bldg,Room 1138, Chicago, IL 60612 USA.
EM akvern@comcast.net
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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NR 19
TC 6
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2016
VL 37
IS 5
BP E489
EP E492
DI 10.1097/BCR.0000000000000284
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA EC5ZD
UT WOS:000388214900010
PM 26284629
DA 2026-07-24
ER

PT J
AU Juntermanns, B
   Kröger, K
   Waldhausen, P
   Gäbel, G
AF Juntermanns, Benjamin
   Kroeger, Knut
   Waldhausen, Peter
   Gaebel, Gabor
TI Venous ulcus cruris-Surgical treatment
SO HAUTARZT
LA German
DT Article
DE Ulcus cruris; Compression therapy; Negative pressure wound therapy;
   Ulcer shaving; Skin transplantation
ID LEG ULCERS; COMPRESSION; THERAPY; SURGERY
AB Venous ulcus cruris is usually a chronic disease and an extreme burden for patients and their families. An analysis based on a random statutory health insurance sample of the AOK Hessen/KV Hessen estimated the number of affected people to be 400,000 in Germany. A venous ulcus cruris is always caused by an underlying chronic venous insufficiency (CVI). A spontaneous healing of this chronic disease without treatment is not to be expected. The conservative treatment includes an adequate compression treatment and exudate management. Surgical treatment is based on three pillars: an open surgical or endovenous approach to resolve the pathological venous reflux, uIcer surgery and in rare cases the various procedures of fascia surgery as well as defect coverage by a combination of negative pressure wound therapy and skin transplantation.
C1 [Juntermanns, Benjamin; Waldhausen, Peter] MVZ Gefassmed Krefeld, Luisenpl 6-8, D-47799 Krefeld, Germany.
   [Juntermanns, Benjamin; Kroeger, Knut; Waldhausen, Peter; Gaebel, Gabor] HELIOS Klinikum Krefeld, Klin Gefassmed, Krefeld, Germany.
C3 Helios Kliniken
RP Juntermanns, B (通讯作者)，MVZ Gefassmed Krefeld, Luisenpl 6-8, D-47799 Krefeld, Germany.
EM benjamin.juntermanns@helios-gesundheit.de
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NR 48
TC 2
Z9 2
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD JUN
PY 2022
VL 73
IS 6
SI SI
BP 491
EP 500
DI 10.1007/s00105-022-05006-4
EA MAY 2022
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1S3XR
UT WOS:000794107100001
PM 35551422
DA 2026-07-24
ER

PT J
AU Moradian, S
   Klapper, AM
AF Moradian, Scott
   Klapper, Andrew M.
TI A novel way to treat skin tears
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Random pattern flap; Skin graft; Skin
   tear; Wound treatment
AB Skin tears are one of the most commonly treated wounds in the elderly population. In their most basic form, they are essentially traumatic random pattern flaps. We postulate that the injured blood flow to these skin flaps should be ignored and the tissue should be treated as a skin graft. A case report is presented of an 86-year-old female with an 8 x 35 cm skin tear to her right upper extremity after a hip fracture. In addition to conventional wound closure strips re-approximating the tissues, a disposable negative pressure wound therapy device was placed to act as bolster. Upon its removal on day 5, the opposed skin tear tissue was found to be 100% viable. We therefore propose that this update may be an improvement over classical skin tear treatments and should be followed up with a case series.
C1 [Moradian, Scott] Delray Med Ctr, Dept Gen Surg, Delray Beach, FL 33446 USA.
   [Klapper, Andrew M.] Delray Med Ctr, Wound Treatment Ctr, Delray Beach, FL 33446 USA.
RP Klapper, AM (通讯作者)，Delray Med Ctr, 13660 Jog Rd,Suite 4, Delray Beach, FL 33446 USA.
EM Klappermd@AndrewKlapper.com
CR Carville K, 2007, WOUND PRACT RES, V15, P18
   Clemens Mark W, 2010, Semin Plast Surg, V24, P43, DOI 10.1055/s-0030-1253239
   LeBlanc K, 2009, ADV SKIN WOUND CARE, V22, P325, DOI 10.1097/01.ASW.0000305484.60616.e8
   LeBlanc K, 2014, INT WOUND J, V11, P424, DOI 10.1111/iwj.12203
   LeBlanc Kimberly, 2011, Adv Skin Wound Care, V24, P2, DOI 10.1097/01.ASW.0000405316.99011.95
   Payne R L, 1993, Ostomy Wound Manage, V39, P16
   Vandervord JG, 2016, INT WOUND J, V13, P59, DOI 10.1111/iwj.12227
NR 7
TC 3
Z9 4
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2016
VL 13
IS 2
BP 283
EP 286
DI 10.1111/iwj.12426
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DH2UF
UT WOS:000372641400021
PM 25756343
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Tan, Y
   Wang, X
   Li, H
   Zheng, Q
   Li, J
   Feng, G
   Pan, ZJ
AF Tan, Y.
   Wang, X.
   Li, H.
   Zheng, Q.
   Li, J.
   Feng, G.
   Pan, Zhijun
TI The clinical efficacy of the vacuum-assisted closure therapy in the
   management of adult osteomyelitis
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Vacuum-assisted closure; Osteomyelitis; Debridement; Granulation tissue
ID SOFT-TISSUE INJURIES; NEGATIVE-PRESSURE; WOUND THERAPY; INFECTION;
   FRACTURES; DIAGNOSIS; TRIAL; STATE
AB Vacuum-assisted closure (VAC) therapy is a sophisticated development of a standard surgical procedure. The purpose of this study is to evaluate the clinical efficacy of managing adult osteomyelitis with VAC therapy.
   We included a total of 68 patients that developed osteomyelitis with Cierny-Mader types 2, 3 and 4, and required open wound management between March 2005 and February 2009. In this study, 35 of these patients were treated by VAC therapy and the other 33 by conventional wound management. The patients were well compared with type, debridement times, wounds coverage, bacteriology and recurrence.
   Of the study, the patients treated by VAC therapy had a significantly reduced recurrence (1 vs. 7 wounds, P < 0.05), decreased rate of further autodermoplasty or flap surgery (17 vs. 26 wounds, P < 0.05), and increased cases of bacterial species cultures to negative (29 vs. 15 wounds, P < 0.05), debridement times and type were similar between the two groups.
   VAC therapy represents a good clinical efficacy in treating osteomyelitis; it can promote the granulation tissue formation, bacterial clearance, and reduce the needs for tissue transfer and muscle flaps in patients. In addition, it could be used as an adjuvant for the eradication of osteomyelitis and improving soft-tissue management, it may be more suitable for treating osteomyelitis with soft-tissue problems.
C1 [Tan, Y.; Wang, X.; Li, H.; Zheng, Q.; Li, J.; Feng, G.; Pan, Zhijun] Zhejiang Univ, Sch Med, Dept Orthopaed Surg, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Pan, ZJ (通讯作者)，Zhejiang Univ, Sch Med, Dept Orthopaed Surg, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China.
EM drtany@hotmail.com
RI Pan, Zhijun/AAD-6547-2022
FU Medicine Health Sciences Fund of Zhejiang [2008A095]; Natural Science
   Foundation of Zhejiang [Y208034, Y2100111]
FX This study was supported by the Medicine Health Sciences Fund of
   Zhejiang (2008A095) and the Natural Science Foundation of Zhejiang
   (Y208034, Y2100111).
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NR 30
TC 27
Z9 38
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD FEB
PY 2011
VL 131
IS 2
BP 255
EP 259
DI 10.1007/s00402-010-1197-x
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 716OQ
UT WOS:000286983700017
PM 21181410
DA 2026-07-24
ER

PT J
AU Assenza, M
   Cozza, V
   Sacco, E
   Clementi, I
   Tarantino, B
   Passafiume, F
   Valesini, L
   Bartolucci, P
   Modini, C
AF Assenza, M.
   Cozza, V.
   Sacco, E.
   Clementi, I.
   Tarantino, B.
   Passafiume, F.
   Valesini, L.
   Bartolucci, P.
   Modini, C.
TI VAC (Vacuum Assisted Closure) treatment in Fournier's gangrene: personal
   experience and literature review
SO CLINICA TERAPEUTICA
LA English
DT Article
DE critically ill patient; fournier's gangrene; infection; necrotizing
   fasciitis; perineum; vacuum assisted closure (VAC)
ID NECROTIZING FASCIITIS; MANAGEMENT; THERAPY; DISEASE; DEVICE
AB Introduction. Fournier's gangrene (FG) is a rapidly developing necrotizing fasciitis that originates in genital and perineal region. The mortality rate is high and requires prompt diagnosis, antibiotic treatment and extensive necrosectomy with derivative colostomy. Vacuum Assisted Closure (VAC) is a wound care system of paramount importance in the treatment of complex wounds, including the perineum.
   Materials and Methods. We evaluated 6 cases of FG (males, mean age: 54.6 yrs) of the last 3 years (February 2008-August 2010). All patients were diabetics. We used intravenous antibiotic treatment and early surgical debridement with colostomy, followed by immediate positioning of a VAC device (NP 125-200 mmHg). The dressing changes were done every 3-4 days. Hyperbaric oxygen therapy (HBOT) was given only to one patient. Microbiological etiology was assessed by multiple cultures to tailor the antimicrobial treatment.
   Results. The VAC therapy reduces the number of dressings and the hospital length of stay (LOS), in agreement with the literature; in one of the cases a secondary reconstructive surgical intervention was possible. The colostomy was reversed in all patients within 3 months.
   Conclusions. Negative pressure is a time saving device, reducing days of hospitalization, patient's discomfort and number of medications. The possibility of a early reconstructive surgery improves significantly quality of life. Clin Ter 2011; 162(1):e1-e5
C1 [Assenza, M.; Sacco, E.; Clementi, I.; Tarantino, B.; Valesini, L.; Bartolucci, P.; Modini, C.] Univ Roma La Sapienza, Policlin Umberto 1, Dept Emergency, Rome, Italy.
   [Cozza, V.; Passafiume, F.] Univ Roma La Sapienza, Policlin Umberto 1, Dept Gen Surg, Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Sapienza
   University Rome; University Hospital Sapienza Rome
RP Assenza, M (通讯作者)，Via Demetriade 58, I-00178 Rome, Italy.
EM marco.assenza@uniroma1.it
RI ; ASSENZA, Marco/LLK-2745-2024
OI Cozza, Valerio/0000-0003-3863-5485; ASSENZA, Marco/0000-0002-0400-5410
CR Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
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NR 25
TC 36
Z9 45
U1 0
U2 5
PU SOC EDITRICE UNIV
PI ROME
PA VIA G B MORGAGNI 1, ROME, 10061, ITALY
SN 0009-9074
J9 CLIN TER
JI Clin. Ter.
PD JAN-FEB
PY 2011
VL 162
IS 1
BP E1
EP E5
PG 5
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 736GB
UT WOS:000288477800011
PM 21448535
DA 2026-07-24
ER

PT J
AU Egin, S
   Alemdar, A
   Saglam, F
   Güney, B
   Güven, H
AF Egin, Seracettin
   Alemdar, Ali
   Saglam, Fazil
   Guney, Burak
   Guven, Hakan
TI Treatment with vacuum-assisted closure system: A case of anastomotic
   leak after upper gastrointestinal surgery
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Anastomotic leak; oesophageal stent; open abdomen; vacuum assisted
   closure
ID MANAGEMENT
AB Presently described is a case treated via stent and vacuum-assisted closure (VAC). The patient developed an oesophagojejunostomy leak (OL) on the ninth postoperative day after a radical total gastrectomy.The patient was a 55-year-old male patient with adenocarcinoma localized to the small curvature on the corpus of the stomach. Relaparatomy was performed for the OL, including placement of an uncovered stent.The abdomen was washed 4 times.As the OL did not decrease, 2 covered stents (22 mm and 18 mm in diameter and 80 mm long) were inserted endoscopically.The OL continued to contaminate the abdomen. One tip of the VAC sponge was placed next to the anastomosis, and the other tip was removed from the left upper quadrant. Another VAC closure set was placed in the abdomen. Both VAC closures were connected to separate vacuum devices with 75 mmHg of pressure.VAC dressings were changed at regular intervals every 3 days, and these steps were repeated 7 times over 21 days.The covered stents were removed endoscopically in the final operation. Fistulography revealed that the OL was completely closed, and the VAC dressings were removed.The skin was closed by separating the subcutaneous oil layer of the fascia.VAC therapy can not only provide serious abdominal sepsis treatment and primary source control, but also accelerate granulation development and, in this case, quickly closed the anastomotic leakage.
C1 [Egin, Seracettin; Alemdar, Ali; Saglam, Fazil; Guney, Burak; Guven, Hakan] Univ Hlth Sci, Okmeydani Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Istanbul Okmeydani Training &
   Research Hospital
RP Egin, S (通讯作者)，Saglik Bilimleri Univ, Okmeydani Egitim & Arastirma Hastanesi, Gen Cerrahi Klin, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Alemdar, Ali/HKV-6078-2023; Eğin, Seracettin/GQZ-0908-2022; Guney,
   Burak/NTR-0972-2025
CR Aurello P, 2015, AM SURGEON, V81, P450
   Dellinger RP, 2008, CRIT CARE MED, V36, P296, DOI 10.1097/01.CCM.0000298158.12101.41
   Etoh T, 2010, SURG LAPARO ENDO PER, V20, P332, DOI 10.1097/SLE.0b013e3181f39ff1
   Hoeppner J, 2014, SURG ENDOSC, V28, P1703, DOI 10.1007/s00464-013-3379-4
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   Schaheen L, 2014, AM J SURG, V208, P536, DOI 10.1016/j.amjsurg.2014.05.011
   Schein M, 2002, LANGENBECK ARCH SURG, V387, P1, DOI 10.1007/s00423-002-0276-z
NR 8
TC 1
Z9 1
U1 0
U2 1
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD NOV
PY 2018
VL 24
IS 6
BP 601
EP 603
DI 10.5505/tjtes.2018.23238
PG 3
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA HJ3CB
UT WOS:000457046100018
PM 30516264
DA 2026-07-24
ER

PT J
AU Weiland, DE
AF Weiland, Dennis E.
TI Fasciotomy closure using simultaneous vacuum-assisted closure and
   hyperbaric oxygen
SO AMERICAN SURGEON
LA English
DT Article
ID ISCHEMIA-REPERFUSION INJURY; NO-REFLOW PHENOMENON; SKELETAL-MUSCLE;
   BLOOD-FLOW; MICROCIRCULATION; MANAGEMENT; THERAPY
AB Fasciotomies performed for compartment syndrome and ischemic vascular disease often requires closure in 2 to 4 weeks by skin graft. This leaves the patient with an unsightly scar and a limb with reduced strength. The use of vacuum-assisted closure (VAC) and hyperbaric oxygen therapy (HBOT) quickly reduce the edema and permit earlier closure with adjacent skin. A study of three trauma patients with compartment syndrome, fasciotomies, and the use of the VAC and HBOT to close the fasciotomy wounds with adjacent skin is presented. The pathophysiology of compartment syndrome and ischemia-reperfusion syndrome is discussed. These patients had closure of the fasciotomy wounds in 3 to 18 days. The simultaneous use of HBOT and VAC accelerates the reduction of edema in a synergistic fashion, permitting early closure of fasciotomy wounds.
C1 Scottsdale Healthcare, Scottsdale, AZ USA.
C3 Scottsdale Healthcare Osborn
RP Weiland, DE (通讯作者)，11779 N 114th Way, Scottsdale, AZ 85259 USA.
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NR 24
TC 11
Z9 15
U1 0
U2 2
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD MAR
PY 2007
VL 73
IS 3
BP 261
EP 266
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 139LF
UT WOS:000244432600013
PM 17375783
DA 2026-07-24
ER

PT J
AU Cro, C
   George, KJ
   Donnelly, J
   Irwin, ST
   Gardiner, KR
AF Cro, C
   George, KJ
   Donnelly, J
   Irwin, ST
   Gardiner, KR
TI Vacuum assisted closure system in the management of enterocutaneous
   fistulae
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
AB Background: A very important yet often troublesome element in the conservative management of enterocutaneous fistulae is the protection of the surrounding skin from contact with the effluent, This report describes the successful use of a vacuum assisted closure (VAC) system in dealing with this problem.
   Methods: The results of using the VAC system were studied in three patients with moderate or high volume output enterocutaneous fistulae where conventional treatment had failed to prevent skin excoriation.
   Results: The VAC system was found to be highly effective in controlling fistula effluent and in promoting healing of excoriated skin in all three patients. Complete healing of the fistula was also achieved in two of the three patients.
   Conclusion: The VAC system can be an effective and economically viable method of containing fistula effluent and protecting the skin of patients with enterocutaneous fistulae. Contrary to conventional thought, the VAC system may also actually promote healing of the fistula.
C1 Royal Victoria Hosp, Colorectal Surg Unit, Belfast BT12 6BA, Antrim, North Ireland.
   Royal Victoria Hosp, Intestinal Failure Clin, Belfast BT12 6BA, Antrim, North Ireland.
RP Gardiner, KR (通讯作者)，Royal Victoria Hosp, Colorectal Surg Unit, Grosvenor Rd, Belfast BT12 6BA, Antrim, North Ireland.
RI George, K Joshi/LUA-0409-2024
OI George, K Joshi/0000-0002-1149-2536
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Berry SM, 1996, SURG CLIN N AM, V76, P1009, DOI 10.1016/S0039-6109(05)70495-3
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   *KCI MED, 1997, VAC ASS WOUND HEAL
   *KCI MED, 2000, UK PRIC LIST
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   Morykwas M J., 1997, J South Orthop Assoc, V6, P284
NR 8
TC 94
Z9 109
U1 0
U2 4
PU BRITISH MED JOURNAL PUBL GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JUN
PY 2002
VL 78
IS 920
BP 364
EP 365
DI 10.1136/pmj.78.920.364
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 565WD
UT WOS:000176391700012
PM 12151694
OA Bronze
DA 2026-07-24
ER

PT J
AU Kang, GCW
   Por, YC
   Tan, BK
AF Kang, Gavin Chun-Wui
   Por, Yong Chen
   Tan, Bien-Keem
TI In Vivo Tissue Engineering Over Wounds With Exposed Bone and Tendon
   Autologous Dermal Grafting and Vacuum-assisted Closure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE autologous dermis graft; vacuum-assisted closure; wound; exposed bone;
   joint and tendon; in vivo tissue engineering
ID MANAGEMENT; THERAPY
AB Flap coverage is ideal for wounds exposing bone and tendon, but technically less demanding and speedier options might be considered for small shallow wounds and for wounds with adjacent tissue loss precluding local flaps. We revisited the use of autologous dermal grafting-in combination with vacuum-assisted closure (VAC)-for such wounds.
   Five small-to medium-sized wounds exposing bone, joint, and/or tendon were each covered using an autologous meshed dermal graft followed by VAC application to induce granulation. Closure was completed at 2 weeks by split-thickness skin grafting over the granulating dermis graft.
   Complete and stable wound healing was achieved in all cases within 4 weeks of dermal grafting over exposed bone with excellent outcome at 1 year in terms of donor site healing and return to function. All healed wounds had a nearly flush profile with no bulkiness in the foot and toe region.
   Autologous dermal grafting with VAC is an integrated in vivo tissue engineering system in which the meshed dermis acts as an attractive scaffold for granulation within the conducive VAC-medium. As an alternative to flap surgery or dermal substitutes, the technique is simple, swift, and cost-effective for immediate closure of small shallow wounds and even multiple small wounds, exposing bone and tendon particularly in the lower legs, feet, and toes.
C1 [Kang, Gavin Chun-Wui; Por, Yong Chen; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@singnet.com.sg
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NR 10
TC 23
Z9 27
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2010
VL 65
IS 1
BP 70
EP 73
DI 10.1097/SAP.0b013e3181a72f77
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 616YB
UT WOS:000279246300017
PM 20548234
DA 2026-07-24
ER

PT J
AU Comellas, E
   Bellomo, FJ
   Rosales, I
   del Castillo, LF
   Sánchez, R
   Turon, P
   Oller, S
AF Comellas, Ester
   Bellomo, Facundo J.
   Rosales, Ivan
   del Castillo, Luis F.
   Sanchez, Ricardo
   Turon, Pau
   Oller, Sergio
TI On the feasibility of the computational modelling of the endoluminal
   vacuum-assisted closure of an oesophageal anastomotic leakage
SO ROYAL SOCIETY OPEN SCIENCE
LA English
DT Article
DE endoluminal vacuum-assisted closure; healing; growth; finite-element
   analysis; constitutive modelling
ID PRESSURE WOUND THERAPY; GASTROINTESTINAL ANASTOMOSES; MANAGEMENT;
   GROWTH; COMPLICATIONS; STRICTURES; SURGERY; STENT; STATE
AB Endoluminal vacuum-assisted closure (E-VAC) is a promising therapy to treat anastomotic leakages of the oesophagus and bowel which are associated with high morbidity and mortality rates. An open-pore polyurethane foam is introduced into the leakage cavity and connected to a device that applies a suction pressure to accelerate the closure of the defect. Computational analysis of this healing process can advance our understanding of the biomechanical mechanisms at play. To this aim, we use a dual-stage finite-element analysis in which (i) the structural problem addresses the cavity reduction caused by the suction and (ii) a new constitutive formulation models tissue healing via permanent deformations coupled to a stiffness increase. The numerical implementation in an in-house code is described and a qualitative example illustrates the basic characteristics of the model. The computational model successfully reproduces the generic closure of an anastomotic leakage cavity, supporting the hypothesis that suction pressure promotes healing by means of the aforementioned mechanisms. However, the current framework needs to be enriched with empirical data to help advance device designs and treatment guidelines. Nonetheless, this conceptual study confirms that computational analysis can reproduce E-VAC of anastomotic leakages and establishes the bases for better understanding the mechanobiology of anastomotic defect healing.
C1 [Comellas, Ester; Oller, Sergio] Int Ctr Numer Methods Engn CIMNE, Campus Nord,Bldg C1,C Gran Capita S-N, Barcelona 08034, Spain.
   [Bellomo, Facundo J.] Natl Univ Salta, Fac Engn, CONICET, INIQUI, Av Bolivia 5150, RA-4400 Salta, Argentina.
   [Rosales, Ivan; del Castillo, Luis F.; Sanchez, Ricardo; Turon, Pau] B Braun Surg SA, Carretera Terrassa 121, Barcelona 08191, Spain.
   [Oller, Sergio] Univ Politecn Cataluna, ETSECCPB, Dept Civil & Environm Engn, Barcelona Tech, Campus Nord,Bldg C1,C Jordi Girona 1-3, ES-08034 Barcelona, Spain.
   [Comellas, Ester] Univ Erlangen Nurnberg, Inst Appl Mech, Egerlandstr 5, D-91058 Erlangen, Germany.
C3 Universitat Politecnica de Catalunya; Centre Internacional de Metodes
   Numerics en Enginyeria (CIMNE); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universitat Politecnica de Catalunya;
   University of Erlangen Nuremberg
RP Comellas, E (通讯作者)，Int Ctr Numer Methods Engn CIMNE, Campus Nord,Bldg C1,C Gran Capita S-N, Barcelona 08034, Spain.; Comellas, E (通讯作者)，Univ Erlangen Nurnberg, Inst Appl Mech, Egerlandstr 5, D-91058 Erlangen, Germany.
EM ester.comellas@fau.de
RI Oller, Sergio/M-2376-2014; Comellas, Ester/KCL-5139-2024
OI Oller, Sergio/0000-0002-5203-8903; Turon, Pau/0000-0001-6354-9701;
   Comellas, Ester/0000-0002-3981-2634
FU B. Braun Surgical, S.A.; Spanish 'Ministerio de Economia y Competividad'
   [BIA2015-67807-R-RESCICLO]
FX This work has been funded by B. Braun Surgical, S.A. S.O. acknowledges
   partial funding by the Spanish 'Ministerio de Economia y Competividad'
   through the project: BIA2015-67807-R-RESCICLO.
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NR 63
TC 3
Z9 3
U1 0
U2 5
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 2054-5703
J9 ROY SOC OPEN SCI
JI R. Soc. Open Sci.
PD FEB
PY 2018
VL 5
IS 2
AR 171289
DI 10.1098/rsos.171289
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FX9YA
UT WOS:000426465700030
PM 29515846
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gul, MO
   Sunamak, O
   Kina, U
   Gunay, E
   Akyuz, C
AF Gul, M. O.
   Sunamak, O.
   Kina, U.
   Gunay, E.
   Akyuz, C.
TI Fournier's Gangrene: Our Five-Year Series and the Role of
   Vacuum-Assisted Closure in the Treatment
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Debridement; Fournier's gangrene; mortality; vacuum-assisted closure
ID HYPERBARIC-OXYGEN THERAPY; RETROSPECTIVE ANALYSIS; MANAGEMENT
AB Background: Fournier's Gangrene (FG) is the necrotizing fasciitis of the perineal region. Aims: To compare the effectiveness of debridement alone and debridement with vacuum-assisted closure in the treatment of Fournier's gangrene. Methods: Twenty-two patients operated for FG were analyzed retrospectively. Debridement-only and debridement + VAC treatment groups were compared in terms of age, gender, predisposing factors, comorbid diseases, intensive care unit and hospital stay durations, laboratory results, septic shock, treatment methods, Fournier' gangrene severity index (FGSI) and mortality. Results: The M/F ratio was 13/9. There were 10 and 12 patients in debridement-only and debridement + VAC groups, respectively. Ten patients (45.5%) were admitted to intensive care unit, 8 (36.4%) needed colostomy and 7 (31.9%) developed septic shock, respectively. The mortality rate was 27.3%. There was no significant difference in terms of age, gender, laboratory parameters, number of debridement, length of stay in intensive care unit and hospital, shock duration, and mortality (P > 0.05). The FGSI scores also did not show any difference between the groups which showed that the severity of the disease in both groups are similar. Conclusion: The VAC treatment was found not to provide a statistically significant benefit on mortality. Early and adequate debridement and antibiotic are still the most important factors in the treatment of FG and to reduce mortality.
C1 [Gul, M. O.] Cukurova Univ, Balcali Training & Res Hosp, Dept Surg Oncol, Adana, Turkey.
   [Sunamak, O.; Kina, U.; Gunay, E.; Akyuz, C.] Haydarpasa Numune Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
C3 Cukurova University; Istanbul Haydarpasa Sultan Abdulhamid Training &
   Research Hospital; Istanbul Haydarpasa Numune Training & Research
   Hospital
RP Gul, MO (通讯作者)，Cukurova Univ, Balcali Training & Res Hosp, Dept Surg Oncol, Adana, Turkey.
EM mehmetonurgul@hotmail.com
RI ; Gul, Mehmet Onur/AAB-6045-2021
OI KINA KILIÇASLAN, UMUT/0000-0002-3118-5701; 
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 31
TC 12
Z9 14
U1 1
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD SEP
PY 2021
VL 24
IS 9
BP 1277
EP 1282
DI 10.4103/njcp.njcp_387_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YT4UW
UT WOS:000751358000003
PM 34531337
OA gold
DA 2026-07-24
ER

PT J
AU Tewarie, L
   Chernigov, N
   Goetzenich, A
   Moza, A
   Autschbach, R
   Zayat, R
AF Tewarie, Lachmandath
   Chernigov, Nikolay
   Goetzenich, Andreas
   Moza, Ajay
   Autschbach, Ruediger
   Zayat, Rashad
TI The Effect of Ultrasound-Assisted Debridement Combined with Vacuum Pump
   Therapy in Deep Sternal Wound Infections
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE cardiac surgery; postoperative complications; sternal wound infection;
   ultrasonic-assisted wound debridement; vacuum-assisted wound closure
ID LOW-FREQUENCY ULTRASOUND; VENOUS LEG ULCERS; BIOFILMS; EXPERIENCE;
   BACTERIAL; CLOSURE
AB Purpose: To assess whether a combined treatment of low-frequency (25 kHz) ultrasonic-debridement systems followed by vacuum-assisted wound closure (VAC) produces a better outcome in deep sternal wound infections (SWIs) compared to that of VAC alone.
   Methods: We evaluated 45 consecutive patients (25 males) between January 2013 and December 2016, in whom deep SWI was treated with a combination of low-frequency ultrasonic debridement system followed by vacuum-assisted closure (group A, n = 23) or with only vacuum-assisted closure therapy (group B, n = 22). Our final step in both groups was a secondary wound closure with a musculocutaneous flap.
   Results: In both groups, a similar variety of bacteria were isolated. The time between eradication and secondary wound closure was significantly shorter in group A (7.3 +/- 4.8 vs. 19.9 +/- 17.2 days, p = 0.001). After a third debridement session, 95.7% of microbiological cultures were negative in group A versus 54.5% in B (p = 0.001). Duration of antibiotic treatment (p = 0.003) and hospitalization time (p = 0.0001) were significantly shorter in group A.
   Conclusion: The use of low-frequency ultrasonic debridement system is an effective, less invasive technique to combat wound infection. In combination with vacuum-assisted closure therapy, we documented good mid-term results in our patients.
C1 [Tewarie, Lachmandath; Chernigov, Nikolay; Goetzenich, Andreas; Moza, Ajay; Autschbach, Ruediger; Zayat, Rashad] RWTH Univ Hosp, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Zayat, R (通讯作者)，RWTH Univ Hosp, Dept Thorac & Cardiovasc Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
EM rzayat@ukaachen.de
RI Goetzenich, Andreas/ISB-7317-2023; Zayat, Rashad/K-1543-2019; Moza,
   Ajay/KFR-7226-2024
OI Goetzenich, Andreas/0000-0002-3652-7766; Zayat,
   Rashad/0000-0003-2243-8743; 
FU Soring, Quickborn, Germany
FX This study was supported by a research grant from Soring, Quickborn,
   Germany. LT received the grant. The sponsor was not involved in any
   phase of the study preparation, data collection, data analysis, or
   manuscript preparation.
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NR 19
TC 9
Z9 14
U1 0
U2 3
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2018
VL 24
IS 3
BP 139
EP 146
DI 10.5761/atcs.oa.17-00244
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA GJ7RK
UT WOS:000435586500004
PM 29563372
OA gold
DA 2026-07-24
ER

PT J
AU Aydin, U
   Gorur, A
   Findik, O
   Yildirim, A
   Kocogullari, CU
AF Aydin, Ufuk
   Gorur, Alper
   Findik, Orhan
   Yildirim, Abdullah
   Kocogullari, Cevdet Ugur
TI Therapeutic efficacy of vacuum-assisted-closure therapy in the treatment
   of lymphatic complications following peripheral vascular interventions
   and surgeries
SO VASCULAR
LA English
DT Article
DE Lymphatic system; complication; vacuum-assisted closure
ID PRESSURE WOUND THERAPY; GROIN; INFECTIONS; LYMPHORRHEA; LYMPHOCELE;
   GRAFT
AB Objectives Lymphatic complications, lymphocele and lymphorrhea being the leading, are generally encountered after vascular interventions and surgeries. The present study aimed to evaluate the outcomes of vacuum-assisted-closure (VAC) therapy, which we frequently prefer as the first-choice treatment for such complications.
   Materials and methods Among patients undergoing peripheral vascular intervention or surgery between January 2008 and February 2012, the medical files of 21 patients who received VAC therapy or other treatment due to symptomatic lymphatic complications were retrospectively analyzed and the results were discussed.
   Results Group I consisted of 10 patients (three with lymphocele and seven with lymphorrhea) who underwent VAC therapy as the first-choice treatment, Group II consisted of 11 patients of which 7 patients received various therapies before VAC therapy and 4 patients received other treatments alone. The patients who received VAC therapy as the primary therapy demonstrated more rapid wound healing, early drainage control, and shorter hospital stay. The mean hospital medical cost was Euro1038 (range, Euro739-1826) for the patients who primarily underwent VAC therapy; it was calculated to be Euro2137 (range, Euro1610-3130) for the other patients (p=0.001).
   Conclusion In addition to its safety and good clinical outcomes, VAC therapy also has economic advantages and should be the primary method for the treatment of lymphatic complications.
C1 [Aydin, Ufuk; Gorur, Alper; Findik, Orhan; Kocogullari, Cevdet Ugur] Kocaeli Derince Training & Res Hosp, Dept Cardiovasc Surg, Kocaeli, Turkey.
   [Yildirim, Abdullah] Kocaeli Derince Training & Res Hosp, Dept Plast & Reconstruct Surg, Kocaeli, Turkey.
C3 Kocaeli Derince Training & Research Hospital; Kocaeli Derince Training &
   Research Hospital
RP Aydin, U (通讯作者)，Kocaeli Derince Training & Res Hosp, Dept Cardiovasc Surg, Kocaeli, Turkey.
EM nesruf@isnet.net.tr
RI Aydin, Ufuk/GRK-0110-2022; GÖRÜR, DURMUŞ ALPER/HIZ-8555-2022;
   kocogullari, cevdet ugur/KRP-5775-2024; findik, orhan/LZH-3310-2025
OI Aydin, Ufuk/0000-0002-4083-6211; GÖRÜR, DURMUŞ
   ALPER/0000-0002-0004-173X; kocogullari, cevdet ugur/0000-0002-6303-2478;
   
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
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NR 18
TC 11
Z9 15
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD FEB
PY 2015
VL 23
IS 1
BP 41
EP 46
DI 10.1177/1708538114529950
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AZ3BH
UT WOS:000348102300006
PM 24676535
DA 2026-07-24
ER

PT J
AU Labler, L
   Keel, M
   Trentz, O
AF Labler, L
   Keel, M
   Trentz, O
TI New application of VAC® (Vacuum Assisted Closure) in the abdominal
   cavity in case of open abdomen therapy
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE open abdomen; infection; vacuum assisted closure; VAC((R))
ID DAMAGE-CONTROL LAPAROTOMY; MASSIVE VENTRAL HERNIAS; AORTIC-ANEURYSM
   REPAIR; COMPARTMENT SYNDROME; PACK TECHNIQUE; WOUND CONTROL; PRESSURE;
   MESH; EXPERIENCE; TRAUMA
AB Objective: The problem of the temporary vacuum assisted closure (V.A.C.(R)) of open abdomen situation is that the fluids, following the negative pressure, pass the abdominal cavity and in case of a local infection disseminate over the whole abdominal cavity.
   Methods: The usual open abdominal wound V.A.C.(R) technique was modified by using an auxiliary, independently operating V.A.C.(R) system positioned intra-abdominally and connected with a separate drainage tube introduced into the lateral abdominal wall. This arrangement prevents further spreading of a local intra-abdominal infection in case of a necrotising pancreatitis after traumatic pancreas rupture.
   Results: The drainage volumes were comparable from superficial and intra-abdominal V.A.C.(R) system. A total of 30 reoperations were necessary due to a leasion of the pancreas before a primary closure of the open abdominal wound could be applied after 72 days. No bowel fistulas or intra-abdominal abscess formations were observed. The follow-up have not shown any hernia of the abdominal wall up to the present.
   Conclusion: Additional intra-abdominally positioned V.A.C.(R) system with an own drainage system supports open abdomen therapy with the standard abdominal V.A.C.(R) system and prevents dissemination of intra-abdominal infection.
C1 Univ Zurich Hosp, Unfallchirurg Klin, Dept Chirurg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Unfallchirurg Klin, Dept Chirurg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@chi.usz.ch
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NR 37
TC 17
Z9 23
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S14
EP S19
DI 10.1055/s-2004.822668
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600006
PM 15168276
DA 2026-07-24
ER

PT J
AU Bludau, M
   Hölscher, AH
   Herbold, T
   Leers, JM
   Gutschow, C
   Fuchs, H
   Schröder, W
AF Bludau, M.
   Hoelscher, A. H.
   Herbold, T.
   Leers, J. M.
   Gutschow, C.
   Fuchs, H.
   Schroeder, W.
TI Management of upper intestinal leaks using an endoscopic vacuum-assisted
   closure system (E-VAC)
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Esophageal perforation; Anastomotic leakage; Endoscopic vacuum-assisted
   closure system
ID ESOPHAGEAL-PERFORATION; ANASTOMOTIC LEAKAGE; RESECTION; THERAPY; OPTIONS
AB Esophageal perforations and postoperative leakage of esophagogastrostomy are considered to be life-threatening conditions due to the development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC), a well-established treatment method for superficial infected wounds, is based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy is a novel method, and experience with its esophageal application is limited.
   This retrospective study summarizes the experience of a center with a high volume of upper gastrointestinal surgery using E-VAC therapy for patients with leakages of the esophagus. The study investigated 14 patients who had esophageal defects treated with E-VAC. Three patients had a spontaneous defect; two patients had an iatrogenic defect; and nine patients had a postoperative esophageal defect.
   The average duration of application was 12.1 days, and an average of 3.9 E-VAC systems were used. For 6 of the 14 patients, E-VAC therapy was combined with the placement of self-expanding metal stents. Complete restoration of the esophageal defect was achieved in 12 (86 %) of the 14 patients. Two patients died due to prolonged sepsis.
   This report demonstrates that E-VAC therapy adds an additional treatment option for partial esophageal wall defects. The combination of E-VAC treatment and endoscopic stenting is a successful novel procedure for achieving a high closure rate.
C1 [Bludau, M.; Hoelscher, A. H.; Herbold, T.; Leers, J. M.; Gutschow, C.; Fuchs, H.; Schroeder, W.] Univ Cologne, Dept Gen Visceral & Canc Surg, D-50937 Cologne, Germany.
C3 University of Cologne
RP Bludau, M (通讯作者)，Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
EM marc.bludau@uk-koeln.de; wolfgang.schroeder@uni-koeln.de
RI /AAP-2598-2021
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
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   Wedemeyer J, 2010, GASTROINTEST ENDOSC, V71, P382, DOI 10.1016/j.gie.2009.07.011
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
NR 17
TC 109
Z9 129
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2014
VL 28
IS 3
BP 896
EP 901
DI 10.1007/s00464-013-3244-5
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AB7HX
UT WOS:000331961500026
PM 24149851
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Giovannini, UM
   Demaria, RG
   Teot, L
AF Giovannini, UM
   Demaria, RG
   Teot, L
TI Interest of negative pressure therapy in the treatment of postoperative
   sepsis in cardiovascular surgery
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB The treatment of postoperative wound dehiscence in cardiovascular surgery remains challenging, especially when a vascular prosthesis or the internal bone is exposed or infected. In 1986, Argenta, et al., suggested negative pressure for managing difficult acute and chronic wounds. This method involves applying continuous suction to the surface of the wound to promote wound healing. We used the vacuum-assisted closure (VAC) system in 15 patients with postoperative sternal dehiscence or unheated vascular approaches. All 15 wounds were infected. In most cases, VAC therapy was associated with decreases in defect size and infection and with rapid filling of the defect with granulation tissue. These improvements allowed wound closure without reconstructive surgery or easy coverage by skin grafting or pedicled muscle Flaps. This study odds to existing evidence that continuous suction promotes healing of infected surgical wounds after cardiovascular surgery.
C1 CHU Mountpellier, Dept Burns & Plastic Surg, F-34259 Mountpellier, France.
   Univ Milan, Inst Human Biopathol, Milan, Italy.
   CHU Mountpellier, Dept Cardiovasc Surg, F-34259 Mountpellier, France.
C3 University of Milan
RP Teot, L (通讯作者)，CHU Mountpellier, Dept Burns & Plastic Surg, 371 Av D Giraud, F-34259 Mountpellier, France.
EM lteot@aol.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DEMARIA R, 1999, J AUT SOC CHIR THOR
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas M J, 1997, J South Orthop Assoc, V6, P279
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
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   SERRY C, 1980, J THORAC CARDIOV SUR, V80, P861
   Tang A T, 2000, J Wound Care, V9, P229
   TEOT L, 2000, 10 ANN M EUR TISS RE
NR 10
TC 10
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR-APR
PY 2001
VL 13
IS 2
BP 82
EP 87
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 430WT
UT WOS:000168599000007
DA 2026-07-24
ER

PT J
AU Park, CA
   Defranzo, AJ
   Marks, MW
   Molnar, JA
AF Park, Christopher A.
   Defranzo, Anthony J.
   Marks, Malcolm W.
   Molnar, Joseph A.
TI Outpatient Reconstruction Using Integra and Subatmospheric Pressure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE outpatient; Integra; subatmospheric pressure; Vacuum Assisted Closure;
   VAC; VAC; wound care; reconstruction; burn contracture; skin graft
ID VACUUM-ASSISTED CLOSURE; ARTIFICIAL SKIN; WOUND CONTROL; SURGERY; TRIAL;
   BURNS
AB Integra (Integra Lifesciences Corporation, Plainsboro, NJ) has been used in a variety of reconstructive surgical procedures. The application of Integra using subatmospheric pressure (V.A.C., Kinetic Concepts, Inc, San Antonio, TX) has been suggested to be easier, faster, and more consistent than previous dressings, allowing grafting as soon as I week after Integra placement. Ten patients were chosen for outpatient reconstructive surgery with Integra and subatmospheric pressure with skin grafting 7-10 days (mean = 8 days) post-Integra. Skin graft take was 75% to 160% (mean = 91.5%). No patients required additional grafting or reconstruction. Integra may be successfully used for reconstruction of difficult areas as an outpatient in combination with subatmospheric pressure (V.A.C.). This allows for expedited treatment, decreased morbidity, and lower cost versus standard Integra application.
C1 [Park, Christopher A.; Defranzo, Anthony J.; Marks, Malcolm W.; Molnar, Joseph A.] Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Park, CA (通讯作者)，Wake Forest Univ, Baptist Med Ctr, Dept Plast & Reconstruct Surg, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM cpark@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
FU KCI, Inc.
FX Wake Forest University School of Medicine receives royalties from the
   sale and use of the V.A.C. and distributes a portion of the royalties to
   Louis C. Argenta, MD, and Michael Motykwas, PhD. Joseph A. Molnar, MD,
   PhD, receives research funds from KCI, Inc. (the manufacturer of the
   V.A.C.), and receives compensation for presentations at educalional
   symposia sponsored by KCI, Inc.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Fang P, 2002, J BURN CARE REHABIL, V23, P327, DOI 10.1097/00004630-200209000-00005
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Grant I, 2001, BURNS, V27, P699, DOI 10.1016/S0305-4179(01)00040-7
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   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Sheridan RL, 1999, BURNS, V25, P97, DOI 10.1016/S0305-4179(98)00176-4
NR 16
TC 40
Z9 43
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2009
VL 62
IS 2
BP 164
EP 169
DI 10.1097/SAP.0b013e31817d87cb
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 397RV
UT WOS:000262680700014
PM 19158527
DA 2026-07-24
ER

PT J
AU Martin, DA
   Nanci, GN
   Marlowe, SI
   Larsen, AN
AF Martin, Deborah A.
   Nanci, Gabriella N.
   Marlowe, Steven I.
   Larsen, Alan N.
TI Necrotizing fasciitis with no mortality or limb loss
SO AMERICAN SURGEON
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting and Postgraduate Course Program of the
   Southeastern-Surgical-Congress
CY FEB 09-12, 2008
CL Birmingham, AL
SP SE Surg Congress
ID RESISTANT STAPHYLOCOCCUS-AUREUS; STREPTOCOCCAL INFECTIONS; GANGRENE
AB Necrotizing fasciitis is a potentially lethal invasive soft tissue infection. Early aggressive antibiotic therapy and surgical debridement have been the hallmark of successful therapy. It is commonly held that delays in surgical debridement significantly increase the mortality rate and rate of limb loss. A mortality rate of 20 per cent or greater has been reported throughout the last 80 years. We recently reviewed the cases of 20 consecutive patients admitted to our hospital in various stages of necrotizing fasciitis progression. Treatment of all 20 patients consisted of antibiotic therapy and surgical debridement, with frequent follow-up serial debridement. Topical negative pressure was achieved with the use of the Vacuum Assisted Closure system. An aggressive surgical approach, (including the frequency of debridement, appropriate antibiotic utilization, and use of the Vacuum Assisted Closure system), significantly impacted our results, despite delays in treatment and progression of the infection.
C1 [Martin, Deborah A.; Nanci, Gabriella N.; Marlowe, Steven I.; Larsen, Alan N.] Northside Hosp, Atlanta, GA USA.
RP Martin, DA (通讯作者)，960 Johnson Ferry Rd,Sidle 143, Atlanta, GA 30342 USA.
EM dmartinmdfacs@bellsouth.net
RI Martins, Deborah/LRU-0382-2024
CR Anaya DA, 2005, ARCH SURG-CHICAGO, V140, P151, DOI 10.1001/archsurg.140.2.151
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Bisno AL, 1996, NEW ENGL J MED, V334, P240, DOI 10.1056/NEJM199601253340407
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   Kaul R, 1997, AM J MED, V103, P18, DOI 10.1016/S0002-9343(97)00160-5
   Lee TC, 2007, AM J SURG, V194, P809, DOI 10.1016/j.amjsurg.2007.08.047
   MAJESKI JA, 1983, AM J SURG, V145, P784, DOI 10.1016/0002-9610(83)90140-X
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   Miller LG, 2005, NEW ENGL J MED, V352, P1445, DOI 10.1056/NEJMoa042683
   STEPHENS BJ, 1993, AM SURGEON, V59, P149
   STEVENS DL, 1989, NEW ENGL J MED, V321, P1, DOI 10.1056/NEJM198907063210101
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   Zimbelman J, 1999, PEDIATR INFECT DIS J, V18, P1096, DOI 10.1097/00006454-199912000-00014
NR 14
TC 6
Z9 6
U1 0
U2 0
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD SEP
PY 2008
VL 74
IS 9
BP 809
EP 812
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 344NC
UT WOS:000258933400007
PM 18807667
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Ludusanu, A
   Zara, MT
   Corlade-Andrei, M
   Tanevski, A
   Stan, CI
   Chiran, DA
   Vintila, D
   Andronic, D
   Balan, G
AF Ciuntu, Bogdan Mihnea
   Ludusanu, Andreea
   Zara, Mara Teodora
   Corlade-Andrei, Mihaela
   Tanevski, Adelina
   Stan, Cristinel Ionel
   Chiran, Dragos Andrei
   Vintila, Dan
   Andronic, Dan
   Balan, Gheorghe
TI Recurrent Cervical Esophageal Fistula and Retroesophageal Abscess
   Following Surgical Management of Zenker's Diverticulum
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Zenker's diverticulum; cervical esophageal fistula; extraluminal VAC;
   vacuum-assisted closure; minimally invasive therapy
AB Background: Zenker's diverticulum arises from the posterior hypopharyngeal wall through Killian's dehiscence and predominantly affects older adults. Surgical and endoscopic treatments may be complicated by adverse events, including recurrent laryngeal nerve injury, cervical emphysema, mediastinitis, and pharyngoesophageal fistula formation. Methods: We report the case of a 69-year-old male who underwent open surgical treatment for Zenker's diverticulum and subsequently developed an upper esophageal fistula complicated by a retroesophageal abscess. Results: The patient was treated using an externally adapted endoluminal vacuum-assisted closure system (EndoVAC), which enabled continuous drainage, local lavage, and progressive closure of the esophageal defect. Conclusions: Endo-VAC therapy represents a safe and minimally invasive therapeutic option for the management of postoperative esophageal fistulas following Zenker's diverticulum surgery and may reduce the need for extensive esophageal reconstruction.
C1 [Ciuntu, Bogdan Mihnea; Ludusanu, Andreea; Zara, Mara Teodora; Corlade-Andrei, Mihaela; Tanevski, Adelina; Stan, Cristinel Ionel; Chiran, Dragos Andrei; Vintila, Dan; Andronic, Dan; Balan, Gheorghe] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Univ St 16, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy
RP Ludusanu, A; Zara, MT (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Univ St 16, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; andreea.ludusanu@umfiasi.ro;
   marazara13@yahoo.com; mihaela.corlade2@umfiasi.ro;
   papancea.adelina@umfiasi.ro; cristinel.stan@umfiasi.ro;
   dragos-andrei.chiran@umfiasi.ro; dan.vintila@umfiasi.ro;
   dan.andronic@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Stan, Cristinel/AAL-5618-2020; Ciuntu, Bogdan/MTF-9477-2025; Tanevski,
   Adelina/LUZ-8095-2024; Corlade-Andrei, Mihaela/HGB-3725-2022; Chiran,
   Dragos Andrei/MTF-7766-2025
OI Ludușanu, Andreea/0009-0003-1785-5785; 
FX This research received no external funding.
CR Abdulsada Mustafa, 2020, VideoGIE, V5, P8, DOI [10.1016/j.vgie.2019.10.004, 10.1016/j.vgie.2019.10.004]
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NR 24
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 7
PY 2026
VL 15
IS 7
AR 2777
DI 10.3390/jcm15072777
EA APR 2026
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GK8JJ
UT WOS:001738782000001
PM 41977077
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hsia, JC
   Moe, KS
AF Hsia, Jennifer C.
   Moe, Kris S.
TI Vacuum-Assisted Closure Therapy for Reconstruction of Soft-Tissue
   Forehead Defects
SO ARCHIVES OF FACIAL PLASTIC SURGERY
LA English
DT Article
ID MANAGEMENT
AB We sought to examine the efficacy of vacuum-assisted closure (VAC) therapy for the reconstruction of full-thickness forehead defects and to determine the appropriate therapeutic strategies for its use. Medical records and photographs were reviewed for 3 patients with full-thickness tissue loss of the forehead region treated with a VAC system. All 3 patients had complete formation of healthy granulation tissue with VAC therapy alone. One patient was treated to full reepithelization of her wound; the other 2 patients underwent successful surgical closure after VAC reduction of the defect. The treatment was well tolerated, with no complications. Although this represents an initial study, it seems that the protocol for VAC therapy presented herein is a reliable technique for the repair of forehead defects that provides excellent functional and aesthetic outcomes. Arch Facial Plast Surg. 2011;13(4):278-282
C1 [Hsia, Jennifer C.; Moe, Kris S.] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Hsia, JC (通讯作者)，Univ Washington, Dept Otolaryngol Head & Neck Surg, Mail Stop 356515, Seattle, WA 98195 USA.
EM jchsia@u.washington.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
   Beasley Nigel J P, 2004, Arch Facial Plast Surg, V6, P16, DOI 10.1001/archfaci.6.1.16
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
   Eyileten Z, 2009, SURG TODAY, V39, P947, DOI 10.1007/s00595-008-3982-5
   Frodel John L Jr, 2004, Arch Facial Plast Surg, V6, P54, DOI 10.1001/archfaci.6.1.54
   Gassner HG, 2006, MAYO CLIN PROC, V81, P1023, DOI 10.4065/81.8.1023
   Genden EM, 2004, ORAL ONCOL, V40, P979, DOI 10.1016/j.oraloncology.2004.01.012
   KAWASHIMA T, 1994, PLAST RECONSTR SURG, V94, P944, DOI 10.1097/00006534-199412000-00007
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   MAILLARD GF, 1991, ANN PLAS SURG, V26, P347, DOI 10.1097/00000637-199104000-00009
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   Seternes A, 2010, EUR J VASC ENDOVASC, V40, P60, DOI 10.1016/j.ejvs.2010.02.018
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
NR 15
TC 12
Z9 15
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 1521-2491
J9 ARCH FACIAL PLAST S
JI Arch. Facial Plast. Surg.
PD JUL-AUG
PY 2011
VL 13
IS 4
BP 278
EP 282
DI 10.1001/archfacial.2011.40
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 793QU
UT WOS:000292839000010
PM 21768563
DA 2026-07-24
ER

PT J
AU Stokes, TH
   Follmar, KE
   Silverstein, AD
   Weizer, AZ
   Donatucci, CF
   Anderson, EE
   Erdmann, D
AF Stokes, Tracey H.
   Follmar, Keith E.
   Silverstein, Ari D.
   Weizer, Alon Z.
   Donatucci, Craig F.
   Anderson, Everett E.
   Erdmann, Detlev
TI Use of negative-pressure dressings and split-thickness skin grafts
   following penile shaft reduction and reduction scrotoplasty in the
   management of penoscrotal elephantiasis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE elephantiasis; penoscrotal lymphedema; penile reconstruction;
   split-thickness skin graft; vacuum-assisted closure dressing
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; LYMPHEDEMA; SCROTUM; BOLSTER
AB From 1988 to 2005, 8 men who presented with penoscrotal elephantiasis underwent penile shaft degloving and reduction scrotoplasty, followed by transplantation of a split-thickness skin graft (STSG) to the penile shaft. The etiology of elephantiasis in these patients included self-injection of viscous fluid and postsurgical obstructive lymphedema. In the 6 most recent cases, negative-pressure dressings were applied over the STSG to promote graft take, and STSG take rate was 100%. The results of our series corroborate those of a previous report, which showed circumferential negative-pressure dressings to be safe and efficacious in bolstering STSGs to the penile shaft. Furthermore, these results suggest that the use of negative-pressure dressings may improve graft take in this patient population.
C1 Duke Univ, Med Ctr, Div Plast Reconstruct Maxillofacial & Oral Surg, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Div Urol, Durham, NC 27710 USA.
   Duke Univ, Sch Med, Durham, NC 27710 USA.
C3 Duke University; Duke University; Duke University
RP Erdmann, D (通讯作者)，Duke Univ, Med Ctr, Div Plast Reconstruct Maxillofacial & Oral Surg, Box 3181, Durham, NC 27710 USA.
EM Detlev.Erdmann@duke.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BEHAR TA, 1993, PLAST RECONSTR SURG, V91, P352, DOI 10.1097/00006534-199302000-00024
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   DANDAPAT MC, 1985, AM J SURG, V149, P686
   Jones SM, 2005, PLAST RECONSTR SURG, V116, P1023, DOI 10.1097/01.prs.0000178399.68254.13
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Ndoye A, 1999, BJU INT, V84, P362
   O'Rourke M G, 1967, Br J Urol, V39, P426, DOI 10.1111/j.1464-410X.1967.tb09824.x
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NR 13
TC 34
Z9 36
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2006
VL 56
IS 6
BP 649
EP 653
DI 10.1097/01.sap.0000202826.61782.c9
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 047CN
UT WOS:000237857500013
PM 16721079
DA 2026-07-24
ER

PT J
AU Rao, AJ
   Kempton, SJ
   Erickson, BJ
   Levine, BR
   Rao, VK
AF Rao, Allison J.
   Kempton, Steven J.
   Erickson, Brandon J.
   Levine, Brett R.
   Rao, Venkat K.
TI Soft Tissue Reconstruction and Flap Coverage for Revision Total Knee
   Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE total knee arthroplasty; revision arthroplasty; flap; gastrocnemius;
   reconstruction
ID ANTEROLATERAL THIGH FLAP; VACUUM-ASSISTED CLOSURE; THICKNESS
   SKIN-GRAFTS; MUSCLE-FLAP; WOUND COMPLICATIONS; DEFECTS; GASTROCNEMIUS;
   MANAGEMENT; INFECTION; PEDICLE
AB Background: Total knee arthroplasty is a successful operation for treatment of arthritis. However, devastating wound complications and infections can compromise the knee joint, particularly in revision situations.
   Methods: Soft tissue loss associated with poor wound healing and multiple operations can necessitate the need for reconstruction for wound closure and protection of the prosthesis.
   Results: Coverage options range from simple closure methods to complex reconstruction, including delayed primary closure, healing by secondary intention, vacuum-assisted closure, skin grafting, local flap coverage, and distant microsurgical tissue transfer.
   Conclusion: Understanding the advantages and pitfalls of each reconstructive option helps to guide treatment and avoid repeated operations and potentially devastating consequences such as knee arthrodesis or amputation. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Rao, Allison J.; Erickson, Brandon J.; Levine, Brett R.] Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA.
   [Kempton, Steven J.; Rao, Venkat K.] Univ Wisconsin, Sch Med & Publ Hlth, Div Plast Surg, Madison, WI USA.
C3 Rush University; University of Wisconsin System; University of Wisconsin
   Madison
RP Rao, VK (通讯作者)，Univ Wisconsin Hosp & Clin, Div Plast Surg, 600 Highland Ave,G5-350, Madison, WI 53792 USA.
RI ; Levine, Brett/AAE-1963-2019
OI Rao, Allison/0000-0002-3460-5409; 
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NR 68
TC 47
Z9 59
U1 0
U2 1
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JUL
PY 2016
VL 31
IS 7
BP 1529
EP 1538
DI 10.1016/j.arth.2015.12.054
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DO8WL
UT WOS:000378066000029
PM 27038863
DA 2026-07-24
ER

PT J
AU Colwell, AS
   Donaldson, MC
   Belkin, M
   Orgill, DP
AF Colwell, AS
   Donaldson, MC
   Belkin, M
   Orgill, DP
TI Management of early groin vascular bypass graft infections with
   sartorius and rectus femoris flaps
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ROTATIONAL MUSCLE FLAPS; TERM FOLLOW-UP;
   SALVAGE
AB Groin infections adjacent to vascular bypass grafts continue to be a source of morbidity. The authors reviewed retrospectively 9 consecutive patients with early localized groin infections treated at their institution with sartorius or rectus femoris muscle flaps between 1998 and 2002. All wounds were initially opened and drained. Wounds with necrotic tissue were treated with serial surgical debridements, with a vacuum-assisted closure device, or with wet-to-dry dressing changes. Two bypass grafts were excised and replaced in the presence of marked exposure or pseudoaneurysm. Small wounds were closed with a turnover sartorius flap and larger wounds were closed with either a muscle or musculocutaneous rectus femoris flap. Groin wounds healed in all patients without subsequent graft exposure, rupture, or pseudoaneurysm. Local wound therapy with staged debridement and muscle flaps is effective for most early localized graft infections.
C1 Brigham & Womens Hosp, Div Plast Surg, Dept Surg, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Dept Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR [Anonymous], ANN PLAST SURG
   Atiyeh BS, 1998, ANN PLAS SURG, V41, P640, DOI 10.1097/00000637-199812000-00010
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NR 17
TC 53
Z9 61
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2004
VL 52
IS 1
BP 49
EP 53
DI 10.1097/01.sap.0000099960.68038.53
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 762BD
UT WOS:000187949300009
PM 14676699
DA 2026-07-24
ER

PT J
AU Kang, GCW
   Yam, A
AF Kang, Gavin C. W.
   Yam, Andrew
TI Vacuum-assisted closure of a large palmar defect after debriding a
   midpalmar tuberculous abscess
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Hand; Surgery; Tuberculous infection; Vacuum-assisted closure
AB A rare case of tuberculous deep palmar abscess of the hand was treated with radical excisional debridement, resulting in a large palmar skin and soft tissue defect that was successfully closed with a vacuum dressing followed by split skin grafting. Vacuum dressings are useful adjuncts to treat large soft tissue defects in patients who are unsuitable for complex reconstruction. The moist wound environment prevents desiccation of exposed vital structures and decreases pain, allowing early mobilisation in the hand. The wound granulates and contracts rapidly, allowing earlier skin grafting or faster healing by secondary intention. The closed system vacuum dressing is particularly useful in managing debrided tuberculous soft tissue infections. The dressing is perfectly sealed and requires less frequent changing, decreasing contamination and transmission of tuberculosis to other patients and health care staff, while minimising the risk of secondary nosocomial bacterial infection of the wound.
C1 [Kang, Gavin C. W.; Yam, Andrew] Singapore Gen Hosp, Dept Hand Surg, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Kang, GCW (通讯作者)，Singapore Gen Hosp, Dept Hand Surg, Outram Rd, Singapore 169608, Singapore.
EM gavinkangcw@yahoo.com
RI Yam, Andrew/LJL-4259-2024
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Ford SJ, 2005, EUR J CARDIO-THORAC, V28, P645, DOI 10.1016/j.ejcts.2005.05.030
   Visuthikosol V, 1996, ANN PLAS SURG, V37, P55, DOI 10.1097/00000637-199607000-00009
   Wongworawat MD, 2003, CLIN ORTHOP RELAT R, P45, DOI 10.1097/01.blo.0000084400.53464.02
NR 6
TC 8
Z9 8
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2008
VL 5
IS 1
BP 45
EP 48
DI 10.1111/j.1742-481X.2007.00369.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AT
UT WOS:000207843200008
PM 18336379
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Hutan, M
   Sen, HM
AF Hutan, M., Jr.
   Sen, Hutan M.
TI Sandwich Mesh Abdominal Closure
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE SMAC; VAC; open abdomen
ID VACUUM-ASSISTED CLOSURE
AB The open abdomen carries a high mortality rate and represents a big surgical challenge. The recent introduction of vacuum assisted closure (VAC) introduced new techniques of its management, including STAR - Staged Abdominal Repair, Fabian Protocol, VAC supported with PDS, support with polyglactin mesh and the use of tissue expanders in the staged closure of the open abdomen. One of the methods, SMAC - sandwich mesh abdominal closure, emerged in April 2008 by the clinical group from Germany.
   The authors present their own modification of SMAC and a case report, where it was used. By current literary research it was the first patient in the Central European hospital managed by SMAC VAC.
   The authors of the article conclude that SMAC VAC and its modification is highly effective in the management of the open abdomen (Fig. 5, Ref. 4). Full Text in free PDF www.bmj.sk.
C1 [Hutan, M., Jr.; Sen, Hutan M.] Comenius Univ, Dept Surg 4, Fac Med, SK-85197 Bratislava, Slovakia.
C3 Comenius University Bratislava
RP Hutan, M (通讯作者)，Comenius Univ, Dept Surg 4, Fac Med, Antolska 11, SK-85197 Bratislava, Slovakia.
EM matohuto@yahoo.com
CR Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   WIDMAIER U, 2008, VAC DREI LAND K APR
   Zingales F, 2001, Chir Ital, V53, P821
NR 4
TC 2
Z9 2
U1 0
U2 0
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2010
VL 111
IS 8
BP 461
EP 463
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 649NK
UT WOS:000281778100009
PM 21033628
DA 2026-07-24
ER

PT J
AU Fleischmann, W
   Lang, E
   Kinzl, L
AF Fleischmann, W
   Lang, E
   Kinzl, L
TI Vacuum-assisted closure of wounds following dermatofasciotomy of the leg
SO UNFALLCHIRURG
LA German
DT Article
DE vacuum-assisted closure of wounds; dermatofasciotomy; lower extremity
ID SKIN; EXPANSION
AB Between 1 January 1992 and 15 March 1994 25 patients with compartment syndromes of the lower limb were treated by the vacuum-sealing technique (VS). Ten out of 25 patients had multiple injuries. Eight compartment syndromes were located in the thigh, 14 in the lower leg and 3 in the foot. The average time of VS was 12.7 (4-31) days with 2.1 (1-8) changes per patient. The wounds were either closed by secondary suturing (n=20) or by skin grafts after partial closure of the wounds by suturing (n=5). One patient developed a superficial wound necrosis, which healed spontaneously without invasive surgical treatment. In 52 intraoperative swabs of the wound surface there was bacterial growth in five bacteriologic specimens, but there were no clinical signs of infection.
RP Fleischmann, W (通讯作者)，UNIV ULM, ABT UNFALLCHIRURG HAND & WIEDERHERSTELLUNGSCHIRUG, STEINHOVELSTR 9, D-89075 ULM, GERMANY.
CR BASHIR AH, 1987, BRIT J PLAST SURG, V40, P582, DOI 10.1016/0007-1226(87)90151-2
   Bohm H J, 1994, Aktuelle Traumatol, V24, P140
   ECHTERMEYER V, 1985, HEFTE UNFALLHEILKD, V169, P51
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
   Fleischmann W, 1992, Acta Orthop Belg, V58 Suppl 1, P227
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   HIRSHOWITZ B, 1993, PLAST RECONSTR SURG, V92, P260, DOI 10.1097/00006534-199308000-00010
   ILIZAROV GA, 1989, CLIN ORTHOP RELAT R, P263
   MUTSCHLER W, 1978, Aktuelle Traumatologie, V8, P375
   REGAN MC, 1993, HOST DEFENSE DYSFUNC
   SELLERS DS, 1986, PLAST RECONSTR SURG, V77, P654, DOI 10.1097/00006534-198604000-00027
   WEISE K, 1991, TRAUMATOLOGIE AKTUEL
NR 12
TC 71
Z9 80
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 1996
VL 99
IS 4
BP 283
EP 287
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA UE861
UT WOS:A1996UE86100007
PM 8658208
DA 2026-07-24
ER

PT J
AU Harris, TG
   Pyle, C
AF Harris, Thomas G.
   Pyle, Casey
TI Sharing Cost-Effective Alternatives for the Patient's Benefit: Any
   Problem Can Be Solved with a Little Ingenuity Commentary on an
   article by Hansel Gould B. Cocjin, MD, DPBO, et al.: "Wound-Healing
   Following Negative-PressureWound Therapy with Use of a Locally Developed
   AquaVac System as Compared with the Vacuum-Assisted Closure (VAC)
   System"
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Editorial Material
C1 [Harris, Thomas G.] Harbor UCLA Med Ctr, Torrance, CA 90509 USA.
   Congress Orthopaed, Pasadena, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center
RP Harris, TG (通讯作者)，Harbor UCLA Med Ctr, Torrance, CA 90509 USA.
EM thomasgharrismd@gmail.com
CR [Anonymous], 2015, WHO Compendium of Innovative Health Technologies for Low-Resource Settings 2011-2014: Assistive Devices, EHealth Solutions, Medical Devices, Other Technologies, Technologies for Outbreaks
   Tran VT, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0651-1
NR 2
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD NOV 20
PY 2019
VL 101
IS 22
AR e123
DI 10.2106/JBJS.19.01015
PG 2
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KG0ZQ
UT WOS:000509671300004
PM 31764375
DA 2026-07-24
ER

PT J
AU Demaria, RG
   Giovannini, UM
   Téot, L
   Frapier, JM
   Albat, B
AF Demaria, RG
   Giovannini, UM
   Téot, L
   Frapier, JM
   Albat, B
TI Topical negative pressure therapy. A very useful new method to treat
   severe infected vascular approaches in the groin
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE wound infection; wound healing; vascular surgical procedures; groin;
   femoral artery
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; COMPLICATIONS; MANAGEMENT;
   GRAFTS
AB Aim. The treatment of infected vascular surgery sites is challenging. Negative pressure applied uniformly to the entire wound surface has been shown to allow granulation tissue formation and to promote healing of acute and chronic wounds.
   Methods. We used the Vacuum-Assisted Closure (VAC, Kinetic Concepts Incorporated, San Antonio, Texas, USA) system in 4 patients with severe groin wound infection after emergency surgery on the femoral artery.
   Results. In all 4 patients, general health improved and the wound changed rapidly from a large infected cavity to a minor lesion readily covered using a simple surgical technique.
   Conclusion. This study establishes VAC as a very valuable tool for managing severe complications of groin vascular surgery sites even in patients with obesity and/or diabetes mellitus.
C1 Montpellier Teaching Hosp, Arnaud de Villeneuve Hosp, Dept Cardiovasc Surg, F-34295 Montpellier, France.
   Montpellier Teaching Hosp, Dept Plast Surg, F-34295 Montpellier, France.
   Montpellier Teaching Hosp, Lapeyronie Hosp, Burn Unit, F-34295 Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Universite de Montpellier; CHU de
   Montpellier
RP Demaria, RG (通讯作者)，Montpellier Teaching Hosp, Arnaud de Villeneuve Hosp, Dept Cardiovasc Surg, 371 Av Doyen G Giraud, F-34295 Montpellier, France.
EM roland.demaria@wanadoo.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Giovannini UM, 2001, ANN PLAS SURG, V47, P577, DOI 10.1097/00000637-200111000-00022
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Greer SE, 1999, ANN PLAS SURG, V43, P551, DOI 10.1097/00000637-199911000-00016
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NR 22
TC 31
Z9 38
U1 0
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD DEC
PY 2003
VL 44
IS 6
BP 757
EP 761
PG 5
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 773UF
UT WOS:000188941600015
PM 14735041
DA 2026-07-24
ER

PT J
AU Holle, G
   Germann, G
   Sauerbier, M
   Riedel, K
   von Gregory, H
   Pelzer, M
AF Holle, G.
   Germann, G.
   Sauerbier, M.
   Riedel, K.
   von Gregory, H.
   Pelzer, M.
TI Vacuum-assisted closure therapy and wound coverage in soft tissue injury
SO UNFALLCHIRURG
LA German
DT Article
DE VAC therapy; long-term treatment; acute soft tissue defect; plastic and
   reconstructive surgery; chronic wounds
ID NEGATIVE-PRESSURE DRESSINGS; SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS;
   MANAGEMENT; RECONSTRUCTION; FRACTURES; DEVICE; TRAUMA
AB This study presents the results of a meta-analysis based on the literature dealing with the clinical applications of vacuum-assisted closure (VAC) in the areas of chronic wounds, acute posttraumatic wounds, compartment syndromes, or injuries of the upper extremities. The studies were analysed for validity, significance of conclusion with respect to success rate, publications, and economic efficacy.
   The data show that with VAC a very valuable technique has been added to an integrated therapeutic concept of soft tissue reconstruction. However, clinical data from prospective randomised trials to support some of the positive aspects seen in the daily clinical application of the technique are still missing. These would create a sound basis demonstrating the economic efficacy of the technique.
C1 Heidelberg Univ, Klin Plast & Handchirurg,Schwerbrandverletztenzen, Berufsgenossenschaftliche Unfallklin, Klin Hand Plast & Rekonstrukt Chirurg, D-67071 Ludwigshafen, Germany.
   St Markus Hosp, Klin Plast Chirurg Wiederherstellungs & Handchiru, Frankfurt, Germany.
C3 Ruprecht Karls University Heidelberg
RP Germann, G (通讯作者)，Heidelberg Univ, Klin Plast & Handchirurg,Schwerbrandverletztenzen, Berufsgenossenschaftliche Unfallklin, Klin Hand Plast & Rekonstrukt Chirurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM guenter.germann@urz.uni-heidelberg.de
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARMSTRONG DG, 2002, OSTOMY WOUND MANAG, V44, P64
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
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   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   HOLLE G, 2007, UNPUB UNFALLCHIRURG
   Horch RE, 2004, ZBL CHIR, V129, pS2, DOI 10.1055/s-2004-822644
   Huang Jian, 2003, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V17, P456
   Isago T, 2003, J DERMATOL, V30, P673, DOI 10.1111/j.1346-8138.2003.tb00456.x
   Jones SM, 2005, PLAST RECONSTR SURG, V116, P1023, DOI 10.1097/01.prs.0000178399.68254.13
   Joseph E, 2000, WOUNDS, V12, P60
   Labler L., 2004, Eur J Trauma, V30, P305, DOI 10.1007/s00068-004-1389-6
   *MILL STUD US, 2002, EC ASS KCI US VAC TH
   Miller Quintessa, 2004, Curr Surg, V61, P205, DOI 10.1016/j.cursur.2003.07.015
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Neubauer G, 2004, ZBL CHIR, V129, pS122, DOI 10.1055/s-2004-822673
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   SCHEUFLER O, 2000, Z FLUGWISS WELTRAUM, V13, P32
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NR 29
TC 20
Z9 20
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 2007
VL 110
IS 4
BP 289
EP 300
DI 10.1007/s00113-007-1265-z
PG 12
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 156SN
UT WOS:000245670000001
PM 17404700
DA 2026-07-24
ER

PT J
AU de Lange, MY
   Schasfoort, RA
   Obdeijn, MC
   van der Werff, JFA
   Nicolai, JPA
AF de Lange, MY
   Schasfoort, RA
   Obdeijn, MC
   van der Werff, JFA
   Nicolai, JPA
TI Vacuum-assisted closure: indications and clinical experience
SO EUROPEAN JOURNAL OF PLASTIC SURGERY
LA English
DT Article
DE wound healing; vacuum therapy
ID WOUND CONTROL
AB The use of subatmospheric pressure to promote wound healing has gradually found support in the past few years. The vacuum-assisted closure system uses a pump providing a continuous negative pressure of preferably 125 mmHg, which is distributed over the wound surface by an airtight covered foam. The exact mechanisms of vacuum therapy are not yet understood, but clinically soft tissue defects seem to heal faster when subatmospheric pressure is applied. Our experience with the first 100 patients with soft tissue defects of different origin that were treated with vacuum therapy is presented. In 29 patients, the wounds healed without further surgical intervention, 53 patients underwent secondary wound closure and 11 patients required more than one procedure. Seven patients died due to their underlying disease. Few complications were seen. Vacuum sealing is a new therapeutic concept in wound healing which can precede and sometimes replace surgical wound closure.
C1 Acad Ziekenhuis Groningen, Dept Plast Surg, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen
RP van der Werff, JFA (通讯作者)，Acad Ziekenhuis Groningen, Dept Plast Surg, Postbus 30-001, NL-9700 RB Groningen, Netherlands.
EM j.f.a.van.der.werff@chir.azg.nl
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P, 1998, BRIT J PLAST SURG, V51, P79, DOI 10.1016/S0007-1226(98)80142-2
   FIELD CK, 1994, AM J SURG, V167, pS2, DOI 10.1016/0002-9610(94)90002-7
   Fleischmann W, 1997, UNFALLCHIRURG, V100, P301, DOI 10.1007/s001130050123
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Masters J, 1998, BRIT J PLAST SURG, V51, P267, DOI 10.1016/S0007-1226(98)80028-3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
NR 10
TC 22
Z9 65
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-343X
EI 1435-0130
J9 EUR J PLAST SURG
JI Eur. J. Plast. Surg.
PD MAY
PY 2000
VL 23
IS 4
BP 178
EP 182
DI 10.1007/s002380050244
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 321GE
UT WOS:000087447100006
DA 2026-07-24
ER

PT J
AU Paradiso, FV
   Nanni, L
   Merli, L
   De Marco, EA
   Catania, VD
   Taddei, A
   Manzoni, C
   Conti, G
AF Paradiso, Filomena Valentina
   Nanni, Lorenzo
   Merli, Laura
   De Marco, Erika Adalgisa
   Catania, Vincenzo Davide
   Taddei, Alessandra
   Manzoni, Carlo
   Conti, Giorgio
TI Vacuum assisted closure for the treatment of complex wounds and
   enterocutaneous fistulas in full term and premature neonates: a case
   report
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Preterm; Dehiscence; VAC therapy; Enterocutaneous fistula; Plastic
   surgery; Pediatric surgery
ID MANAGEMENT; THERAPY
AB Background: The Vacuum Assisted Closure (VAC) system has become an effective treatment for acute and chronic wound defects. Although its use has been reported in wound care of children and premature infants, the management of the device in this population has not been well established.
   Case presentation: We report the satisfactory results in two neonates (one full-term and one preterm) with complex wounds secondary to major abdominal surgery. In the premature baby an enterocutaneous fistula was also present. Complete epithelialization of the wounds was achieved in both patients within a few weeks thus avoiding any further surgical procedure.
   Case presentation: The use of VAC system in neonates is safe and effective in the management of complex wounds and should be considered as a first line treatment in the event of a major dehiscence.
C1 [Paradiso, Filomena Valentina; Nanni, Lorenzo; Merli, Laura; De Marco, Erika Adalgisa; Catania, Vincenzo Davide; Taddei, Alessandra; Manzoni, Carlo] Univ Cattolica Sacro Cuore, Sch Med, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
   [Conti, Giorgio] Univ Cattolica Sacro Cuore, Sch Med, Pediat Intens Care Unit, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Paradiso, FV (通讯作者)，Univ Cattolica Sacro Cuore, Sch Med, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM vale.paradiso@gmail.com
RI Catania, Vincenzo Davide/AAH-3310-2020; Paradiso,
   Filomena/OGN-6517-2025; CONTI, Giorgio/AAB-9546-2022
OI Catania, Vincenzo Davide/0000-0002-8387-4680; CONTI,
   Giorgio/0000-0002-8566-9365
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Gabriel A, 2006, J PEDIATR SURG, V41, P1836, DOI 10.1016/j.jpedsurg.2006.06.050
   Gabriel A, 2009, J PLAST RECONSTR AES, V62, P1428, DOI 10.1016/j.bjps.2008.06.033
   Kilbride KE, 2006, J PEDIATR SURG, V41, P212, DOI 10.1016/j.jpedsurg.2005.10.003
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Rentea RM, 2013, J SURG RES, V184, P658, DOI 10.1016/j.jss.2013.05.056
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
NR 13
TC 5
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1720-8424
EI 1824-7288
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD JAN 11
PY 2016
VL 42
AR 2
DI 10.1186/s13052-016-0210-6
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA DB8WI
UT WOS:000368797500001
PM 26754964
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Brown, KM
   Harper, FV
   Aston, WJ
   O'Keefe, PA
   Cameron, CR
AF Brown, KM
   Harper, FV
   Aston, WJ
   O'Keefe, PA
   Cameron, CR
TI Vacuum-assisted closure in the treatment of a 9-year-old child with
   severe and multiple dog bite injuries of the thorax
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
AB The vacuum-assisted closure (VAC; KCI International, San Antonio, TX) device is a negative pressure dressing, which we have used in the treatment of wounds with devitalized or infected tissues. Although introduced in plastic and reconstructive surgery, its use has extended to orthopedic and cardiothoracic surgical practice in the treatment of infected joint replacement and sternal wound infections, respectively. Although the VAC is becoming more widely used in surgical practice, only a small number of case reports exist in addition to the original case series by Argenta and Morykwas in 1997. Previously, the device was described in treating single wounds in adult patients. We report a case where it was successfully used to treat multiple dog bite injuries in a 9-year-old child. (C) 2001 by The Society of Thoracic Surgeons.
C1 Guys Hosp, Dept Cardiothorac Surg, London SE1 9RT, England.
   Guys Hosp, Dept Plast Surg, London SE1 9RT, England.
C3 Guy's & St Thomas' NHS Foundation Trust; Guy's & St Thomas' NHS
   Foundation Trust
RP Brown, KM (通讯作者)，Guys & St Thomas Hosp, Dept Cardiothorac Surg, Guys & St Thomas NHS Trust, London SE1 9RT, England.
RI Brown, Kimberly/AGS-6387-2022
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 3
TC 16
Z9 22
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2001
VL 72
IS 4
BP 1409
EP 1410
DI 10.1016/S0003-4975(01)02844-2
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 479MB
UT WOS:000171407200097
PM 11603487
DA 2026-07-24
ER

PT J
AU Jackson, AE
AF Jackson, A. E.
TI In this issue - September 2016: Portable negative pressure wound therapy
   for skin grafts in dogs•Wellness testing in small animals•Effects of
   pimobendan on myocardial perfusion and pulmonary transit time in
   dogs•Rispens vaccine virus and Marek's disease virus in poultry•A field
   study of ovulation in oestrus mares•Post-weaning growth of beef heifers
SO AUSTRALIAN VETERINARY JOURNAL
LA English
DT Editorial Material
RI /F-1246-2015
CR Apple SM, 2016, AUST VET J, V94, P324, DOI 10.1111/avj.12480
   Barton M, 2016, AUST VET J, V94, P306, DOI 10.1111/avj.12485
   Dell'Osa D, 2016, AUST VET J, V94, P317, DOI 10.1111/avj.12481
   Eppleston J, 2016, AUST VET J, V94, P341, DOI 10.1111/avj.12477
   Finan SA, 2016, AUST VET J, V94, P338, DOI 10.1111/avj.12478
   Miller AJ, 2016, AUST VET J, V94, P309, DOI 10.1111/avj.12474
   Ralapanawe S, 2016, AUST VET J, V94, P329, DOI 10.1111/avj.12479
NR 7
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0005-0423
EI 1751-0813
J9 AUST VET J
JI Aust. Vet. J.
PD SEP
PY 2016
VL 94
IS 9
BP 305
EP 306
DI 10.1111/avj.12484
PG 2
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DW1YL
UT WOS:000383439800015
PM 27569831
OA Bronze
DA 2026-07-24
ER

PT J
AU Tanaydin, V
   Beugels, J
   Andriessen, A
   Sawor, JH
   van der Hulst, RRWJ
AF Tanaydin, V.
   Beugels, J.
   Andriessen, A.
   Sawor, J. H.
   van der Hulst, R. R. W. J.
TI Randomized Controlled Study Comparing Disposable Negative-Pressure Wound
   Therapy with Standard Care in Bilateral Breast Reduction Mammoplasty
   Evaluating Surgical Site Complications and Scar Quality (vol 42, pg 927,
   2018)
SO AESTHETIC PLASTIC SURGERY
LA English
DT Correction
AB The second to last sentence in the Results section of the Abstract should be corrected to, "At 180-days follow-up, there was a significant improvement in total VAS scores.".
C1 [Tanaydin, V.; Beugels, J.; Sawor, J. H.; van der Hulst, R. R. W. J.] Maastricht Univ, Med Ctr, Maastricht, Netherlands.
   [Andriessen, A.] Andriessen Consultants, Malden, Netherlands.
   [Andriessen, A.] Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands.
   [Sawor, J. H.; van der Hulst, R. R. W. J.] VieCuri Med Ctr, Venlo, Netherlands.
C3 Maastricht University; Radboud University Nijmegen; VieCuri Medical
   Center
RP Tanaydin, V (通讯作者)，Maastricht Univ, Med Ctr, Maastricht, Netherlands.
EM volkan.tanaydin@mumc.nl
CR Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
NR 1
TC 8
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2018
VL 42
IS 4
BP 1176
EP 1176
DI 10.1007/s00266-018-1123-0
PG 1
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GO9AV
UT WOS:000440395700036
PM 29610951
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Webster, J
   Scuffham, P
   Stankiewicz, M
   Chaboyer, WP
AF Webster, Joan
   Scuffham, Paul
   Stankiewicz, Monica
   Chaboyer, Wendy P.
TI Negative pressure wound therapy for skin grafts and surgical wounds
   healing by primary intention
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Skin Transplantation; Wound Healing; Bandages; Negative-Pressure Wound
   Therapy [instrumentation; methods]; Randomized Controlled Trials as
   Topic; Surgical Procedures, Operative; Humans
ID VACUUM-ASSISTED-CLOSURE; CONTROLLED-TRIAL; CLINICAL-TRIAL; MANAGEMENT;
   EFFICACY; DEHISCENCE; PREVENTION; EXPERIENCE; INFECTION; SURGERY
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broadening with a range of systems now available on the market, including those designed for use on clean, closed incisions and skin grafts. Reviews have concluded that the evidence for the effectiveness of NPWT remains uncertain, however, it is a rapidly evolving therapy. Consequently, an updated systematic review of the evidence for the effects of NPWT on postoperative wounds expected to heal by primary intention is required.
   Objectives
   To assess the effects of NPWT on surgical wounds (primary closure, skin grafting or flap closure) that are expected to heal by primary intention.
   Search methods
   We searched the following electronic databases to identify reports of relevant randomised clinical trials: the Cochrane Wounds Group Specialised Register (searched 28 January 2014); the Cochrane Central Register of Controlled Trials (CENTRAL; 2013, issue 12); Database of Abstracts of Reviews of Effects (2013, issue 12); Ovid MEDLINE (2011 to January 2014); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 24 January 2014); Ovid EMBASE (2011 to January 2014 Week 44); and EBSCO CINAHL (2011 to January 2014). We conducted a separate search to identify economic evaluations.
   Selection criteria
   We included trials if they allocated patients to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with a different type of NPWT.
   Data collection and analysis
   We assessed trials for their appropriateness for inclusion and for their quality. This was done by three review authors working independently, using pre-determined inclusion and quality criteria.
   Main results
   In this first update, we included an additional four trials, taking the total number of trials included to nine (785 participants). Three trials involved skin grafts, four included orthopaedic patients and two included general surgery and trauma surgery patients; all the included trials had unclear or high risk of bias for one or more of the quality indicators we assessed. Seven trials compared NPWT with a standard dressing (two of these were 'home-made'NPWT devices), one trial compared one 'home-made'NPWT with a commercially available device. In trials where the individual was the unit of randomisation, there were no differences in the incidence of surgical site infections (SSI); wound dehiscence, re-operation (in incisional wounds); seroma/haematoma; or failed skin grafts. Lower re-operation rates were observed among skin graft patients in the ' home-made' NPWT group (7/65; 10.8%) compared to the standard dressing group (17/66; 25.8%) (risk ratio (RR) 0.42; 95% CI 0.19 to 0.92). The mean cost to supply equipment for VAC (R) therapy was USD 96.51/day compared to USD4.22/day for one of the ' home-made' devices (P value 0.01); labour costs for dressing changes were similar for both treatments. Pain intensity score was also reported to be lower in the ' home-made' group when compared with the VAC (R) group (P value 0.02). One of the trials in orthopaedic patients was stopped early because of a high incidence of fracture blisters in the NPWT group (15/24; 62.5%) compared with the standard dressing group (3/36; 8.3%) (RR 7.50; 95% CI 2.43 to 23.14).
   Authors' conclusions
   Evidence for the effects of negative pressure wound therapy (NPWT) for reducing SSI and wound dehiscence remains unclear, as does the effect of NPWT on time to complete healing. Rates of graft loss may be lower when NPWT is used, but hospital-designed and built products are as effective in this area as commercial applications. There are clear cost benefits when non-commercial systems are used to create the negative pressure required for wound therapy, with no evidence of a negative effect on clinical outcome. In one study, pain levels were also rated lower when a ' home-made' system was compared with a commercial counterpart. The high incidence of blisters occurring when NPWT is used following orthopaedic surgery suggests that the therapy should be limited until safety in this population is established. Given the cost and widespread use of NPWT, there is an urgent need for suitably powered, high-quality trials to evaluate the effects of the newer NPWT products that are designed for use on clean, closed surgical incisions. Such trials should focus initially on wounds that may be difficult to heal, such as sternal wounds or incisions on obese patients.
C1 [Webster, Joan] Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Brisbane, Qld 4029, Australia.
   [Webster, Joan; Chaboyer, Wendy P.] Griffith Univ, NHMRC Ctr Res Excellence Nursing, Ctr Hlth Practice Innovat, Griffith Hlth Inst, Brisbane, Qld 4111, Australia.
   [Webster, Joan] Univ Queensland, Sch Nursing & Midwifery, Brisbane, Qld, Australia.
   [Scuffham, Paul] Griffith Univ, Meadowbrook, Qld 4131, Australia.
   [Stankiewicz, Monica] Haut Dermatol, Brisbane, Qld, Australia.
C3 Royal Brisbane & Women's Hospital; University of Queensland; Menzies
   Health Institute Queensland; Griffith University; University of
   Queensland; Griffith University
RP Webster, J (通讯作者)，Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Level 2,Bldg 34,Butterfield St, Brisbane, Qld 4029, Australia.
EM joan_webster@health.qld.gov.au
RI Chaboyer, Wendy/F-9588-2018; Scuffham, Paul/B-3066-2014
OI Chaboyer, Wendy/0000-0001-9528-7814; Scuffham, Paul/0000-0001-5931-642X
FU National Institute for Health research (NIHR)
FX External sourcesThe National Institute for Health research (NIHR) is the
   sole funder of the Cochrane Wounds Group, UK.
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NR 93
TC 109
Z9 131
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2014
IS 10
AR CD009261
DI 10.1002/14651858.CD009261.pub3
PG 66
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AY5YW
UT WOS:000347646000057
PM 25287701
OA Bronze
DA 2026-07-24
ER

PT J
AU Dumville, JC
   Land, L
   Evans, D
   Peinemann, F
AF Dumville, Jo C.
   Land, Lucy
   Evans, Debra
   Peinemann, Frank
TI Negative pressure wound therapy for treating leg ulcers
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ULCERATION; EFFICACY; TRIAL; METAANALYSIS;
   PREVALENCE; IMPACT; CARE
AB Background
   Leg ulcers are open skin wounds that occur between the ankle and the knee that can last weeks, months or even years and are a consequence of arterial or venous valvular insufficiency. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care and is promoted for use on wounds. NPWT involves the application of a wound dressing to the wound, to which a machine is attached. The machine applies a carefully controlled negative pressure (or vacuum), which sucks any wound and tissue fluid away from the treated area into a canister.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) for treating leg ulcers in any care setting.
   Search methods
   For this review, in May 2015 we searched the following databases: the Cochrane Wounds Group Specialised Register (searched 21 May 2015); the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library 2015, Issue 4); Ovid MEDLINE (1946 to 20 May 2015); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 20 May 2015); Ovid EMBASE (1974 to 20 May 2015); EBSCO CINAHL (1982 to 21 May 2015). There were no restrictions based on language or date of publication.
   Selection criteria
   Published or unpublished randomized controlled trials (RCTs) comparing the effects of NPWT with alternative treatments or different types of NPWT in the treatment of leg ulcers.
   Data collection and analysis
   Two review authors independently performed study selection, risk of bias assessment and data extraction.
   Main results
   We included one study, with 60 randomized participants, in the review. The study population had a range of ulcer types that were venous arteriolosclerotic and venous/arterial in origin. Study participants had recalcitrant ulcers that had not healed after treatment over a six-month period. Participants allocated to NPWT received continuous negative pressure until they achieved 100% granulation (wound preparation stage). A punch skin-graft transplantation was conducted and the wound then exposed to further NPWT for four days followed by standard care. Participants allocated to the control arm received standard care with dressings and compression until 100% granulation was achieved. These participants also received a punch skin-graft transplant and then further treatment with standard care. All participants were treated as in-patients until healing occurred.
   There was low quality evidence of a difference in time to healing that favoured the NPWT group: the study reported an adjusted hazard ratio of 3.2, with 95% confidence intervals (CI) 1.7 to 6.2. The follow-up period of the study was a minimum of 12 months.
   There was no evidence of a difference in the total number of ulcers healed (29/30 in each group) over the follow-up period; this finding was also low quality evidence. There was low quality evidence of a difference in time to wound preparation for surgery that favoured NPWT (hazard ratio 2.4, 95% CI 1.2 to 4.7).
   Limited data on adverse events were collected: these provided low quality evidence of no difference in pain scores and Euroqol (EQ5D) scores at eight weeks after surgery.
   Authors' conclusions
   There is limited rigorous RCT evidence available concerning the clinical effectiveness of NPWT in the treatment of leg ulcers. There is some evidence that the treatment may reduce time to healing as part of a treatment that includes a punch skin graft transplant, however, the applicability of this finding may be limited by the very specific context in which NPWT was evaluated. There is no RCT evidence on the effectiveness of NPWT as a primary treatment for leg ulcers.
C1 [Dumville, Jo C.] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Land, Lucy] Birmingham City Univ, Ctr Hlth & Social Care Res, Birmingham, W Midlands, England.
   [Evans, Debra] Birmingham City Univ, Div Community Hlth & Social Work, Birmingham, W Midlands, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, Pediat Oncol & Hematol, D-50931 Cologne, Germany.
C3 University of Manchester; Birmingham City University; Birmingham City
   University; University of Cologne
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI /H-2800-2019; Dumville, Jo/O-7867-2014
OI Land, Lucy/0000-0001-8634-8056; Dumville, Jo/0000-0002-6546-3685
FU School of Nursing, Midwifery and Social Work, University of Manchester,
   UK; National Institute for Health Research, via Cochrane Infrastructure
   [13/89/08]; National Institute for Health Research, via Cochrane
   Programme Grant [13/89/08]; National Insitiute for Health Research
   (NIHR); National Institute for Health Research [13/89/08] Funding
   Source: researchfish
FX Internal sources School of Nursing, Midwifery and Social Work,
   University of Manchester, UK. External sources This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08 - High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health., UK. The National Insitiute for Health Research
   (NIHR) is the sole funder of the Cochrane Wounds Group, UK.
CR [Anonymous], 2004, 2 WORLD UN WOUND HEA
   [Anonymous], COMP PRIC NEG PRESS
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NR 60
TC 64
Z9 72
U1 2
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2015
IS 7
AR CD011354
DI 10.1002/14651858.CD011354.pub2
PG 38
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CQ5MF
UT WOS:000360647800063
PM 26171910
OA Bronze
DA 2026-07-24
ER

PT J
AU Chen, X
   Liu, L
   Nie, W
   Deng, R
   Li, J
   Fu, Q
   Fei, J
   Wang, C
AF Chen, X.
   Liu, L.
   Nie, W.
   Deng, R.
   Li, J.
   Fu, Q.
   Fei, J.
   Wang, C.
TI Vacuum Sealing Drainage Therapy for Refractory Infectious Wound on 16
   Renal Transplant Recipients
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 15th Congress of the Asian-Society-of-Transplantation (CAST)
CY NOV 27-30, 2017
CL Cebu, PHILIPPINES
SP Asian Soc Transplantat
ID NEGATIVE-PRESSURE THERAPY; SURGICAL SITE INFECTION; COMPLICATIONS
AB Background. Refractory infectious wounds on renal transplantation (RT) recipients significantly prolong hospital stay, increase medical costs, and threaten allograft survival. Vacuum sealing drainage (VSD) therapy is a new technique for managing wounds based on the principle of application of controlled negative pressure. The aim of this study was to summarize the efficacy and safety of VSD therapy in the management of refractory infectious wounds following RT.
   Materials and methods. This is a retrospective study of a cohort of 661 consecutive patients who received renal transplants over a period of 3 years in which the data were collected and analyzed retrospectively.
   Results. Out of the 661 patients, 16 (2.4%) developed refractory wound infection following RT. Nineteen organisms were identified by culture from all patients, including 10 patients infected with 1 or more bacteria, 2 patients with fungal infection, and 4 patients with both. Specifically, mucormycosis was demonstrated in 4 patients, pan-resistant Klebsiella pneumoniae in 2 patients, and Acinetobacter baumannii in 2 patients. All 16 patients were treated with VSD therapy for a median of 37 days (range, 6 - 111 days). The number of VSD sets used ranged from 4 to 28 sets (mean, 11.1 sets). A combination of antibiotics, debridement, and VSD therapy lead to 100% (16 of 16) wound healing. No VSD-relevant adverse events were observed.
   Conclusions. VSD therapy is an effective and safe adjunct to conventional treatment modalities for the management of refractory wound infection following RT.
C1 [Chen, X.; Liu, L.; Nie, W.; Deng, R.; Li, J.; Fu, Q.; Fei, J.; Wang, C.] Sun Yat Sen Univ, Affiliated Hosp 1, Organ Transplant Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Wang, C (通讯作者)，58 Zhongshan Rd 2, Guangzhou, Guangdong, Peoples R China.
EM wangchx@mail.sysu.edu.cn
FU National Natural Science Foundation of China [81670680]; Science and
   Technology Planning Project of Guangdong Province, China
   [20146020212006, 2015B020226002]; Science and Technology Program of
   Guangzhou, China [2014Y2-00114]; Guangdong Provincial Key Laboratory on
   Organ Donation and Transplant Immunology [2013A 061401007]
FX This work was supported by the National Natural Science Foundation of
   China (81670680), Science and Technology Planning Project of Guangdong
   Province, China (20146020212006, 2015B020226002), Science and Technology
   Program of Guangzhou, China (2014Y2-00114), and the Guangdong Provincial
   Key Laboratory on Organ Donation and Transplant Immunology (2013A
   061401007).
CR Castrechini Fernandes Franieck M. L., 2014, CHILD DEV RES, V2014, P1, DOI DOI 10.1155/2014/861703
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NR 16
TC 11
Z9 16
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD OCT
PY 2018
VL 50
IS 8
BP 2479
EP 2484
DI 10.1016/j.transproceed.2018.04.014
PG 6
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA GX7MY
UT WOS:000447959000054
PM 30316382
DA 2026-07-24
ER

PT J
AU Zhao, LL
   Yang, JN
   Nie, MY
   Wang, D
   Yan, GJ
   Li, SY
AF Zhao, Lili
   Yang, Jianing
   Nie, Mingyang
   Wang, Dan
   Yan, Guojie
   Li, Shuying
TI 被撤回的出版物: The Application and Evaluation of Effective Quality Management
   by Objectives in Patient Care for Persistent Vacuum Sealing Drainage
   (Retracted Article)
SO JOURNAL OF HEALTHCARE ENGINEERING
LA English
DT Article; Retracted Publication
AB To investigate the application and evaluation of effective quality management by objectives in patient care for persistent vacuum sealing drainage (VSD), a total of 164 patients with fractures of the hands and feet combined with soft tissue damage admitted to the department of hand and foot surgery in a provincial tertiary hospital from January 2018 to January 2020 were selected as study subjects. The patients were randomly divided into observation and control groups based on the types of fractures, with 82 patients in each group, and both groups underwent VSD surgery for treatment. Both of the groups were cared for VSD using the original nursing model and were compared in terms of treatment compliance, wound recovery, the occurrence of complications, and patient satisfaction with nursing work. The treatment compliance of patients in the observation group was higher than that of the control group (P < 0.05). Moreover, the wound healing condition in the observation group and the postoperative wound recovery data were better. The hospitalization time and the number of replacement suckers were less (P < 0.05), which met the requirements of statistical research. This confirmed that the application of quality management by objectives in patient care can improve patient compliance with treatment, promote wound healing, reduce the occurrence of corresponding postoperative complications in patients, and improve patient satisfaction with health nursing, which can be promoted for use in the workplace.
C1 [Zhao, Lili; Yang, Jianing; Nie, Mingyang; Wang, Dan; Yan, Guojie; Li, Shuying] Chengde Med Univ, Affiliated Hosp, Chengde City 067000, Hebei, Peoples R China.
C3 Chengde Medical University
RP Li, SY (通讯作者)，Chengde Med Univ, Affiliated Hosp, Chengde City 067000, Hebei, Peoples R China.
EM zcqzyh@cdmc.edu.cn
RI jn, yang/HTT-3278-2023
CR Bo C., 2016, J PRACTICAL HAND SUR, V30, P333
   Chen L., 2017, LAB MED CLIN, V14, P702
   Danyang Z., 2015, LINGNAN MODERN CLIN, V15, P522
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   Jie X, 2018, J TRAUMA SURG, V20, P485
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NR 14
TC 1
Z9 1
U1 0
U2 29
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2040-2295
EI 2040-2309
J9 J HEALTHC ENG
JI J. Healthc. Eng.
PD AUG 19
PY 2021
VL 2021
AR 1234003
DI 10.1155/2021/1234003
PG 6
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA UJ1ZR
UT WOS:000691092800004
PM 34457215
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Liu, SW
   Wang, CC
   Song, WJ
   Wang, J
   Zhao, SB
AF Liu, Shiwei
   Wang, Congcong
   Song, Wenjing
   Wang, Jun
   Zhao, Shibo
TI A case report of delayed treatment of acute exertional osteofascial
   compartment syndrome in the anterior compartment of the calf
SO MEDICINE
LA English
DT Article
DE acute exertional osteofascial compartment syndrome; fasciotomy; nerve
   injury; vacuum sealing drainage
ID LEG
AB Rationale:Acute exertional osteofascial compartment syndrome (OCS) is a rare cause of lower-leg pain and is often associated with delayed diagnosis, which can lead to irreversible muscle and nerve damage. Patient concerns:A 23-year-old man presented with acute-onset anterior calf pain and ankle dorsiflexion after hiking. Diagnosis:The patient's pain was initially diagnosed as muscle strain at a county hospital, but was eventually diagnosed as OCS at our hospital 8 days after the injury. This case presents several challenges in the diagnosis and treatment phases. Interventions:Three surgeries were performed in total. On the day after admission (9 days after injury), fasciotomy was performed, followed by vacuum sealing drainage (VSD). Six days after the first surgery, necrotic muscle debridement was performed and VSD was reperformed. Ten days after the second surgery, the covering foam material was removed and the incision was sutured. Outcomes:Satisfactory postoperative results were achieved. The erythrocyte sedimentation rate, C-reactive protein level, and white blood cell count were within normal ranges. The skin healed well, and nerve damage and muscle strength improved significantly 3 months after surgery. Lessons:OCS in the absence of trauma or fracture is rare, but treatment delays can have devastating consequences. Acute nontraumatic OCS requires prompt diagnosis and surgical intervention to prevent adverse outcomes. VSD is an effective surgical treatment for this disease.
C1 [Liu, Shiwei; Wang, Congcong; Wang, Jun; Zhao, Shibo] Weifang Med Univ, Affiliated Hosp 1, Joint Surg Dept, Weifang 261000, Shandong, Peoples R China.
   [Song, Wenjing] Weifang Med Univ, Affiliated Hosp 1, Oncol Dept, Weifang, Shandong, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University
RP Zhao, SB (通讯作者)，Weifang Med Univ, Affiliated Hosp 1, Joint Surg Dept, Weifang 261000, Shandong, Peoples R China.
EM 729167145@qq.com; 1764099203@qq.com; 2455187154@qq.com;
   1764099203@qq.com; 18743098435@sohu.com
RI Song, Wenjing/AGB-1735-2022
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NR 21
TC 0
Z9 0
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 30
PY 2022
VL 101
IS 52
DI 10.1097/MD.0000000000032449
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7M9FZ
UT WOS:000906956700030
PM 36596050
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Labler, L
   Trentz, O
AF Labler, L
   Trentz, O
TI VAC™ instillation:: in vitro model.: Part 2
SO BIOMEDIZINISCHE TECHNIK
LA English
DT Article
DE infected wound; VAC; VAC instillation; vacuum assisted closure
AB The behavior of a liquid in foam in the course of the VA.C.(TM) instillation was investigated in an in vitro model by visualization using an aqueous color solution and by a quantitative determination of changing concentration of Ringerlactate solution.
C1 Univ Zurich Hosp, Div Trauma Surg, Dept Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
CR Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   *KIN CONC INC, VAC INSTILL
   Labler L, 2005, BIOMED TECH, V50, P413, DOI 10.1515/BMT.2005.058
   TREADWELL WD, 1943, KURZES LEHRBUCH ANAL, P615
NR 4
TC 4
Z9 4
U1 0
U2 0
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0013-5585
J9 BIOMED TECH
JI Biomed. Tech.
PY 2006
VL 51
IS 1
BP 30
EP 37
DI 10.1515/BMT.2006.007
PG 8
WC Engineering, Biomedical; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Medical Informatics
GA 052HY
UT WOS:000238226000006
PM 16771128
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Wong, R
   Melnyk, M
   Tang, SS
   Nguan, C
AF Wong, Rachel
   Melnyk, Megan
   Tang, Steven S.
   Nguan, Chris
TI Scrotal lymphangiomatosis: a case report
SO CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
LA English
DT Article
ID LYMPHATIC MALFORMATION; SKIN-GRAFTS; RECONSTRUCTION
AB Lymphangiomas are benign tumours of the lymphatic system, and there are several reported cases of scrotal lymphangioma in the literature to date. We report a rare case of multilocular cutaneous lymphangiomatosis treated with surgical excision (total scrotectomy and reconstruction using split-thickness skin grafts with vacuum-assisted closure dressing).
C1 [Wong, Rachel; Melnyk, Megan; Tang, Steven S.; Nguan, Chris] Univ British Columbia, Dept Urol Sci, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Nguan, C (通讯作者)，Univ British Columbia, Dept Urol Sci, Gordon & Leslie Diamond Hlth Care Ctr, Level 6,2775 Laurel St, Vancouver, BC V5Z 1M9, Canada.
EM chris.nguan@ubcurology.com
RI Nguan, Christopher/V-1541-2017
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NR 15
TC 1
Z9 2
U1 0
U2 2
PU CANADIAN UROLOGICAL ASSOCIATION
PI DORVAL
PA 185 DORVAL AVENUE, STE 401, DORVAL, QC H9S 5J9, CANADA
SN 1911-6470
EI 1920-1214
J9 CUAJ-CAN UROL ASSOC
JI CUAJ-Can. Urol. Assoc. J.
PD FEB
PY 2012
VL 6
IS 1
BP E11
EP E14
DI 10.5489/cuaj.10139
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA V39KB
UT WOS:000209408800004
PM 22396376
DA 2026-07-24
ER

PT J
AU Sentenac, J
AF Sentenac, Jean
TI Facilitating wound healing with VAC therapy: the pharmacist's role
SO EJHP PRACTICE
LA English
DT Article
ID ASSISTED CLOSURE; ULCERS
AB Vacuum Assisted Closure (VAC) therapy is a non-invasive system that facilitates wound healing by applying sub-atmospheric pressure to the wound. Because associated consumables are sterile medical devices, they must be supplied by pharmacists in France, who are valued members of the wound management team.
C1 Ctr Hosp, Pharm Sterilisat Dept, F-11890 Carcassonne 9, France.
RP Sentenac, J (通讯作者)，Ctr Hosp, Pharm Sterilisat Dept, Route St Hilaire, F-11890 Carcassonne 9, France.
EM jean.sentenac@ch-carcassonne.fr
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Baharestani M, 2008, ADV SKIN WOUND CARE, V21, P1
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   LEFRANCE B, 2007, EUR C NANT
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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NR 11
TC 0
Z9 0
U1 0
U2 1
PU PHARMA PUBLISHING & MEDIA EUROPE-PPM EUROPE
PI MOL
PA POSTBUS 10001, MOL, B-2400, BELGIUM
SN 1781-9989
EI 2030-3769
J9 EJHP PRACT
JI EJHP Pract.
PY 2008
VL 14
IS 5
BP 57
EP 58
PG 2
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 370GH
UT WOS:000260750200031
DA 2026-07-24
ER

PT J
AU Dai, HY
   Wang, YC
   Xu, JG
   Lv, C
   Dong, J
   Sun, MY
   Chen, KX
   Xiao, Y
   Wu, ML
   Xue, CY
AF Dai, Haiying
   Wang, Yuchong
   Xu, Jianguo
   Lv, Chuan
   Dong, Jie
   Sun, Mengyan
   Chen, Kexin
   Xiao, Yuai
   Wu, Minliang
   Xue, Chunyu
TI Application of maple leaf-shaped flap combined with negative pressure
   wound therapy in the perianal circular skin defect reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE maple leaf-shaped flap; negative pressure wound therapy; perianal
   region; wound repair
ID EXTRAMAMMARY PAGETS-DISEASE; WIDE LOCAL EXCISION; ROTATION FLAP;
   PERINEAL; CLOSURE; REGION; REPAIR
AB We aimed to explore the efficacy of maple leaf-shaped flap in the repair of perianal circular skin defect. This study is a retrospective review of patients with perianal circular skin defect after skin tumour resection and repaired with maple leaf-shaped flap. Patients included in this study were admitted in our department between January 2010 and January 2023. A standardized data collection template was used to collect related variables. The design and surgical procedures of maple leaf-shaped flap are carefully described in this study. Negative pressure wound therapy (NPWT) was applied to assist wound healing postoperatively. Twenty-seven patients were included in this study. The average wound size after tumour resection measured 4 x 5 cm2-10 x 10 cm2. The circular skin defect was repaired by maple leaf-shaped flap, and NPWT was used after surgery. Twenty-five patients achieved primary wound healing and flaps were well-survived. Slight infection occurred in two patients, and both were cured after dressing change. During the follow-up period of 6-24 months, no tumour recurrence occurred. The perianal morphology can be well-restored by maple leaf-shaped flap, and the defecation control function of anus was not impaired. The application of maple leaf-shaped flap and NPWT is a promising way in the repair of perianal circular skin defect with little complication and satisfying outcomes.
C1 [Dai, Haiying; Wang, Yuchong; Xu, Jianguo; Lv, Chuan; Dong, Jie; Sun, Mengyan; Chen, Kexin; Xiao, Yuai; Wu, Minliang; Xue, Chunyu] Naval Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Wu, Minliang] Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Xue, Chunyu] Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University
RP Wu, ML (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Xue, CY (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM wml9398@163.com; xcyfun@sina.com
RI Chen, KeXin/M-5657-2017; Wu, Minliang/GPT-4264-2022; Xu,
   Jian-Guo/JZD-9552-2024
OI Xu, Jian-Guo/0000-0003-2514-5057
CR Conklin A, 2009, J GASTROINTEST SURG, V13, P951, DOI 10.1007/s11605-009-0822-x
   Desvigne M, 2023, WOUNDS, V35, pE173, DOI 10.25270/wnds/20167
   Devulapalli C, 2016, PLAST RECONSTR SURG, V137, P1602, DOI 10.1097/PRS.0000000000002107
   Gaertner WB, 2008, DIS COLON RECTUM, V51, P1842, DOI 10.1007/s10350-008-9409-y
   Hassan I, 2001, AM J SURG, V181, P363, DOI 10.1016/S0002-9610(01)00578-5
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   Wishart KT, 2021, J PLAST RECONSTR AES, V74, P123, DOI 10.1016/j.bjps.2020.08.001
NR 20
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN 31
PY 2024
VL 21
IS 2
AR e14643
DI 10.1111/iwj.14643
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GK6Y1
UT WOS:001152614300001
PM 42052877
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Saini, R
   Jeyaraman, M
   Jayakumar, T
   Iyengar, KP
   Jeyaraman, N
   Jain, VK
AF Saini, Ravi
   Jeyaraman, Madhan
   Jayakumar, Tarun
   Iyengar, Karthikeyan P.
   Jeyaraman, Naveen
   Jain, Vijay Kumar
TI Evolving Role of Negative Pressure Wound Therapy with Instillation and
   Dwell Time (NPWTi-d-) in Management of Trauma and Orthopaedic Wounds:
   Mechanism, Applications and Future Perspectives
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Review
DE Negative pressure wound therapy; Granulation tissue; Wound healing;
   NPWT; NPWTi-d-; Instillation
ID SALINE INSTILLATION; FLUID
AB IntroductionNegative Pressure Wound Therapy (NPWT) is a well-established method to promote wound healing by delivering negative pressure (a vacuum) at the wound site. Enhancement of NPWT techniques may allow an innovative way of treating trauma and orthopaedic wounds which provide unique challenges. We explore the role of negative pressure wound therapy with instillation and dwell time (NPWTi-d-) in the management of trauma and orthopaedic wounds.Materials and MethodsA comprehensive search strategy was conducted using databases of PubMed, Web of Science, Google Scholar, and Cochrane Library with the search words of 'NPWTid' or 'NPWTi-d-' or 'NPWT with instillation' or 'Negative pressure wound treatment with instillation' to generate this narrative review. The mechanism of action of NPWTi-d-, installation solutions and current applications in the trauma and orthopaedic wounds is evaluated.ResultsNPWTi-d- provides additional mechanism to promote wound healing in a spectrum of acute and chronic orthopaedic wounds. The technique allows local delivery of hydration and elution of antibiotics to support growth of healthy granulation tissue. Various mechanism of actions contribute in drawing the wound edges together, reduce oedema, help decontamination, deliver local antibiotic and promote healing.ConclusionNPWTi-d- permits an enhanced, supplementary technique to encourage wound healing in challenging traumatic and orthopaedic wounds. Future applications of NPWTi-d- will depend on cost-effectiveness analysis and development of its application guidelines based on longitudinal, randomized controlled research trials.
C1 [Saini, Ravi; Jain, Vijay Kumar] Dr Ram Manohar Lohia Hosp, Atal Bihari Vajpayee Inst Med Sci, Dept Orthopaed, New Delhi, India.
   [Jeyaraman, Madhan; Jeyaraman, Naveen] ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai, Tamil Nadu, India.
   [Jayakumar, Tarun] KIMS Sunshine Hosp, Dept Orthopaed, Hyderabad, Telangana, India.
   [Iyengar, Karthikeyan P.] Southport & Ormskirk NHS Trust, Trauma & Orthopaed Surg, Southport PR8 6PN, England.
C3 Dr. M.G.R. Educational & Research Institute
RP Jeyaraman, M (通讯作者)，ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai, Tamil Nadu, India.
EM madhanjeyaraman@gmail.com
RI Jain, Vijay/GYJ-5238-2022; Jeyaraman, Madhan/ABB-8464-2020; Iyengar,
   Karthikeyan/S-4529-2019
OI Jain, Vijay/0000-0003-4164-7380; Jayakumar, Tarun/0000-0002-4305-1022;
   Jeyaraman, Madhan/0000-0002-9045-9493; Iyengar,
   Karthikeyan/0000-0002-4379-1266
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
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   Biermann N, 2023, J CLIN MED, V12, DOI 10.3390/jcm12020711
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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   Dalla Paola L, 2013, INT WOUND J, V10, P25, DOI 10.1111/iwj.12174
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   Diehm YF, 2020, INT WOUND J, V17, P1740, DOI 10.1111/iwj.13462
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   Enodien B, 2021, J SURG CASE REP, DOI 10.1093/jscr/rjab167
   Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
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   Fernández LG, 2020, WOUNDS, V32, P279
   Gabriel A, 2012, INT WOUND J, V9, P25, DOI 10.1111/j.1742-481X.2012.01014.x
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Giri P, 2021, ANN MED SURG, V61, P73, DOI 10.1016/j.amsu.2020.12.015
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   Hasan MY, 2015, DIABET FOOT ANKLE, V6, DOI 10.3402/dfa.v6.27618
   Hasegawa IG, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.4511
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   Kanapathy M, 2020, INT WOUND J, V17, P1948, DOI 10.1111/iwj.13487
   Katsumi S, 2022, EUR SPINE J, V31, P3776, DOI 10.1007/s00586-022-07367-9
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2015, Wounds, V27, pS2
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   Normandin S, 2021, SEMIN PLAST SURG, V35, P164, DOI 10.1055/s-0041-1731792
   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Reider K, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3515
   Rupert P, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.920
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   Sike HU., 2019, J CLIN TRANSFUSION L, V21, P211, DOI [10.3969/j.issn.1671-2587.2019.02.029, DOI 10.3969/J.ISSN.1671-2587.2019.02.029]
   Tingting S, 2023, FRONT SURG, V10, DOI 10.3389/fsurg.2023.1080838
   Uchida DT, 2023, AAPS PHARMSCITECH, V24, DOI 10.1208/s12249-023-02503-0
   Wu LJ, 2022, INT WOUND J, V19, P1449, DOI 10.1111/iwj.13741
   Yang C, 2017, WOUNDS, V29, P240
   Yoon Sung Ji, 2020, Journal of Wound Management and Research, V16, P13, DOI [10.22467/jwmr.2019.00780, 10.22467/jwmr.2019.00780]
   Zhao Y, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/7540020
NR 49
TC 3
Z9 5
U1 2
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD DEC
PY 2023
VL 57
IS 12
BP 1968
EP 1983
DI 10.1007/s43465-023-01018-x
EA NOV 2023
PG 16
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AH4Y5
UT WOS:001092137400002
PM 38009182
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Alamdari, NM
   Mehraneroodi, B
   Gholizadeh, B
   Zeinalpour, A
   Safe, P
   Besharat, S
AF Malekpour Alamdari, Nasser
   Mehraneroodi, Behrooz
   Gholizadeh, Barmak
   Zeinalpour, Adel
   Safe, Parima
   Besharat, Sara
TI The efficacy of negative pressure wound therapy compared with
   conventional dressing in treating infected diabetic foot ulcers: a
   randomized controlled trial
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcer; Conventional
   dressing
AB Introduction Despite advances made in diagnosing and controlling diabetes mellitus (DM), treatment of diabetic foot ulcers (DFUs) is still among challenges faced by physicians. Negative pressure wound therapy (NPWT) is one of newer modalities proposed in the treatment of DFUs. However, there is lack of evidence to support its mileage in this regard. This study was conducted with the aim of assessing the efficacy of NPWT in healing process of DFUs. Materials and methods Sixty patients with DM were randomly allocated into two groups consisting of 30 patients each: the intervention group received sub-atmospheric pressure of - 75 to - 100 mmHg (5 min on, 2 min off) with dressings changed every 48 h, and the control group was treated with silver sulfadiazine dressings, changed twice daily. Patients were followed up until complete closure of ulcers, with a mean duration of 3 months. Results Of the total 60 patients, 27 patients (45%) were females. Most of the patients in both groups had DFUs of grade 2 according to Wegner's classification. Rate of healing of the ulcers was significantly higher by using NPWT (p-value 0.01). NPWT also caused a significant reduction in ulcer surface area, depth, size, major and minor amputations, and disability duration (p-values 0.008, 0.002, 0.02, 0.03, and 0.01, respectively). No significant decrease in occurrence of complications was seen with NPWT. Conclusion NPWT seems to be more efficacious than conventional dressing in treating infected DFUs.
C1 [Malekpour Alamdari, Nasser; Gholizadeh, Barmak; Zeinalpour, Adel] Shahid Beheshti Univ Med Sci, Crit Care Qual Improvement Res Ctr, Shahid Modarres Hosp, Dept Gen Surg, Tehran, Iran.
   [Malekpour Alamdari, Nasser; Mehraneroodi, Behrooz; Safe, Parima] Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Gen Surg, Tehran, Iran.
   [Besharat, Sara] Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Radiol, Yadegar E Emam Highway, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Besharat, S (通讯作者)，Shahid Beheshti Univ Med Sci, Clin Res & Dev Ctr, Shahid Modarres Hosp, Dept Radiol, Yadegar E Emam Highway, Tehran, Iran.
EM besharat.sara@gmail.com
RI /O-5613-2018; Malekpour Alaari, Nasser/H-9889-2017; /AAY-1095-2020
OI Malekpour Alaari, Nasser/0000-0003-3278-9205; 
CR Alavi A, 2014, J AM ACAD DERMATOL, V70, DOI 10.1016/j.jaad.2013.06.055
   Argenta L C., Ann Plast Surg
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Hanneman SK, 2008, AACN ADV CRIT CARE, V19, P223, DOI 10.1097/01.AACN.0000318125.41512.a3
   Hunt NA, 2011, PLAST RECONSTR SURG, V127, p289S, DOI 10.1097/PRS.0b013e3181fbe2a6
   Karatepe O, 2011, ACTA CHIR BELG, V111, P298, DOI 10.1080/00015458.2011.11680757
   Khanolkar MP, 2008, QJM-INT J MED, V101, P685, DOI 10.1093/qjmed/hcn027
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   Sajid MT, 2015, JCPSP-J COLL PHYSICI, V25, P789, DOI 11.2015/JCPSP.789793
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   Söylemez MS, 2016, THER CLIN RISK MANAG, V12, P161, DOI 10.2147/TCRM.S97930
   [孙剑伟 Sun JW], 2007, [中国组织工程研究与临床康复, Journal of Clinical Rehabilitative Tissue Engineering Research], V11, P8908
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   Ulbrecht JS, 2004, CLIN INFECT DIS, V39, pS73, DOI 10.1086/383266
   Vaidhya N, 2015, INDIAN J SURG, V77, pS525, DOI 10.1007/s12262-013-0907-3
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
   Wagner F W Jr, 1981, Foot Ankle, V2, P64
   Wang T, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2871
   Zhang J, 2014, PLAST RECONSTR SURG, V134, P141, DOI 10.1097/PRS.0000000000000275
NR 24
TC 16
Z9 18
U1 6
U2 37
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD OCT
PY 2021
VL 41
IS 4
BP 664
EP 668
DI 10.1007/s13410-021-00941-9
EA MAR 2021
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YA9CF
UT WOS:000625823200001
DA 2026-07-24
ER

PT J
AU Xia, ZG
   Wang, CH
   Arnold, A
   Song, JH
   Tang, YZ
   Xu, QL
   Fang, LS
AF Xia, Zhengguo
   Wang, Chunhua
   Arnold, Ashley
   Song, Junhui
   Tang, Yizhong
   Xu, Qinglian
   Fang, Linsen
TI Efficacy of Treating Chronic Tibial Osteomyelitis With Bone Defect Using
   a Pedicled Perforator-Layered Flap and Fasciocutaneous Flap of the
   Posterior Tibial Artery: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE osteomyelitis; bone defect; negative pressure wound therapy; layered
   flap; tissue flap
AB Introduction. Tibial osteomyelitis is a common complication of bone tissue trauma. Obtaining good soft tissue coverage and effective infection management is key to the treatment of chronic osteomyelitis of the tibia accompanied with bone defect and bone exposure. The pedicled posterior tibial artery perforator layered fasciocutaneous flap can be used to repair soft tissue defects and can be used as a long-term, localized anti-infective. Case Report. A 54-year-old male presented with an ulcer, purulent discharge at the left anterior tibia, and a fever 28 years after complete healing of the scar site. The patient received debridement and negative pressure wound therapy (NPWT) in a hospital setting. After presenting to the authors' department, there was difficulty in closing the exposed bone marrow cavity. On the basis of systemic use of intravenous antibiotics, multiple debridements and NPWT were used to effectively remove necrotic tissue and control infection. Afterward, the pedicled posterior tibial artery perforator layered fasciocutaneous flap was designed to fill the bone marrow cavity as well as cover and seal the wound of bone exposure and soft tissue defect simultaneously. The layered fasciocutaneous flap was well established after operation, and no recurrence of osteomyelitis was found. Conclusion. Debridement with negative pressure wound therapy can be an effective treatment for the wound bed preparation in advance of surgery, and the pedicled posterior tibial artery perforator layered fasciocutaneous flap can be used for the treatment of several soft tissue defects.
C1 [Xia, Zhengguo; Fang, Linsen] Anhui Med Univ, Affiliated Hosp 4, Hefei, Anhui, Peoples R China.
   [Wang, Chunhua; Arnold, Ashley; Song, Junhui; Tang, Yizhong; Xu, Qinglian] Anhui Med Univ, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Fang, LS (通讯作者)，Anhui Med Univ, Affiliated Hosp 4, Dept Wound Repair Plast & Aesthet Surg, 100 Huaihai Rd, Hefei 230000, Anhui, Peoples R China.
EM shaoshangke@126.com
RI Xia, Zhengguo/JOK-2035-2023
OI Xia, Zhengguo/0000-0002-1912-8966
CR Acartürk TO, 2016, J FOOT ANKLE SURG, V55, P362, DOI 10.1053/j.jfas.2014.12.020
   Bekara F, 2018, MICROSURG, V38, P109, DOI 10.1002/micr.30047
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NR 20
TC 4
Z9 4
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2020
VL 32
IS 11
BP E50
EP E54
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6UA
UT WOS:000613577300001
PM 33465040
DA 2026-07-24
ER

PT J
AU Song, WJ
   Choi, HB
   Nam, H
   Lee, CY
   Choi, HJ
AF Song, Woo Jin
   Choi, Hyun Beom
   Nam, Ha Jong
   Lee, Chan Yeong
   Choi, Hwan Jun
TI Transcutaneous oxygen pressure-guided prophylactic fasciotomy and
   negative pressure wound therapy for contrast extravasation injury of the
   hand: A case report
SO MEDICINE
LA English
DT Article
DE compartment syndromes; fasciotomy; negative pressure wound therapy;
   wound healing
AB Rationale:Contrast medium extravasation injury is a rare but potentially limb-threatening complication of intravenous imaging, particularly in anatomically confined regions such as the dorsum of the hand. Thus, adjunctive diagnostic tools are needed to supplement clinical judgment and identify patients who will benefit from early surgical interventions.Patient concerns:A 55-year-old female patient presented with extensive swelling and pain in the left hand following contrast medium extravasation during a computed tomography angiography. The initial physical examination revealed minimal skin changes; however, the patient reported progressive pain and taut swelling.Diagnosis:The examination results were inconclusive of compartment syndrome. Transcutaneous oxygen pressure (TcPO2) monitoring revealed critically low perfusion values (5 mm Hg in the dorsal wrist and 1 mm Hg in the distal dorsum), suggesting evolving ischemia. Forward-looking infrared thermal imaging confirmed localized hypoperfusion.Interventions:Based on TcPO2 and thermal imaging findings, a prophylactic fasciotomy was performed. Negative pressure wound therapy was applied, and primary wound closure was performed on postoperative day 3 without the need for skin grafting.Outcomes:The patient recovered without wound-related complications, and no additional procedures were required.Lessons:This may be the first reported case of contrast medium extravasation injury in the hand managed with TcPO2-guided fasciotomy. TcPO2 and forward-looking infrared thermography may serve as alternative noninvasive tools to support early decision-making for fasciotomy in cases where traditional clinical signs are absent. Early intervention based on perfusion metrics may prevent irreversible ischemic complications.
C1 [Song, Woo Jin; Choi, Hyun Beom; Lee, Chan Yeong] Soonchunhyang Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul Hosp, Seoul, South Korea.
   [Nam, Ha Jong] Soonchunhyang Univ, Gumi Hosp, Dept Plast & Reconstruct Surg, Gumi, South Korea.
   [Choi, Hwan Jun] Soonchunhyang Univ, Cheonan Hosp, Dept Plast & Reconstruct Surg, Cheonan, South Korea.
C3 Soonchunhyang University; Soonchunhyang University; Soonchunhyang
   University
RP Choi, HJ (通讯作者)，Soonchunhyang Univ, Inst Tissue Regenerat, Coll Med, Sooncheonhyang 6 Gil 31, Cheonan Si 31151, Chungcheongnam, South Korea.; Choi, HJ (通讯作者)，Soonchunhyang Univ, Cheonan Hosp, Coll Med, Dept Plast & Reconstruct Surg, Sooncheonhyang 6 Gil 31, Cheonan Si 31151, Chungcheongnam, South Korea.
EM pswjsong@schmc.ac.kr; iprskorea@gmail.com; namssi3@naver.com;
   cksdud1627@naver.com; iprskorea@gmail.com
OI Lee, Chan Yeong/0000-0001-6494-8587; NAM, HA JONG/0000-0002-2494-0991;
   Choi, Hwanjun/0000-0002-0752-0389
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIT) [RS-2025-00523018]; Soonchunhyang University research fund
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT, Grant number
   RS-2025-00523018) and was supported by Soonchunhyang University research
   fund.
CR Arsenault KA, 2011, WOUND REPAIR REGEN, V19, P657, DOI 10.1111/j.1524-475X.2011.00731.x
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NR 13
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 24
PY 2025
VL 104
IS 43
AR e45413
DI 10.1097/MD.0000000000045413
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8YZ6X
UT WOS:001600698300044
PM 41137325
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pedrazzi, NE
   Naiken, S
   La Scala, G
AF Pedrazzi, Nadine Elisabeth
   Naiken, Surennaidoo
   La Scala, Giorgio
TI Negative Pressure Wound Therapy in Pediatric Burn Patients: A Systematic
   Review
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE negative pressure wound therapy; infant; child; adolescent; burns
ID CHILDREN; INFANTS
AB Significance:Negative pressure wound therapy (NPWT) requires the placement of a dressing over a wound, covered with an adhesive film, and applying to these dressing a negative pressure in a controlled fashion. This therapy is a powerful complement to surgical care of wounds. Data are however poor on its use in pediatric burns. Recent Advances:This systematic review, including a total of 466 patients, shows that NPWT as the initial treatment for burned children and after skin grafting has been shown to produce promising results. In the majority of studies, skin graft take rate is close to 100%. This therapy is particularly beneficial in the pediatric population because of less frequent dressing changes and early mobilization. NPWT devices accurately quantify burns water losses and allow tailoring liquid resuscitation. Critical Issues:NPWT is not in the subject of controlled clinical trials in pediatric; most publications are case reports or retrospective reviews. The sporadic complications include bleeding, local infections, and mechanical device issues. Future Directions:NPWT has been used in 2-month up to 18-year-old children with deep second- to third-degree burn of multiple etiologies, from a few days up to several months, on small to 40% total body surface area (%), and in difficult areas. Data gathered provide empirical guidelines on NPWT use in pediatric burns using continuous mode with a pressure of -50 to -75 mmHg for children younger than 2 years, and -75 to -125 mmHg in children over 2 years of age. Prospective randomized studies are needed to provide validated rules.
C1 [Pedrazzi, Nadine Elisabeth; Naiken, Surennaidoo] Univ Geneva Hosp, Dept Surg, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
   [La Scala, Giorgio] Univ Geneva Childrens Hosp, Dept Pediat, Pediat Plast Surg, Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Pedrazzi, NE (通讯作者)，Univ Geneva Hosp, Dept Surg, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland.
EM nadine.pedrazzi@hotmail.com
RI La Scala, Giorgio/AAM-8031-2020
FU Division of Pediatric Surgery, University of Geneva Children's
   Hospitals, Switzerland
FX This work was supported by the Division of Pediatric Surgery, University
   of Geneva Children's Hospitals, Switzerland. The authors would like to
   thank PD Dr. Pfurtscheller from the University Hospital Graz, Austria,
   for sharing the data of his study.
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
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NR 18
TC 17
Z9 23
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAY 1
PY 2021
VL 10
IS 5
BP 270
EP 280
DI 10.1089/wound.2019.1089
EA JUN 2020
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RU2NT
UT WOS:000539607500001
PM 32320366
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cui, HS
   Joo, SY
   Cho, YS
   Park, JH
   Kim, JB
   Seo, CH
AF Cui, Hui Song
   Joo, So Young
   Cho, Yoon Soo
   Park, Ji Heon
   Kim, June-Bum
   Seo, Cheong Hoon
TI Effect of Combining Low Temperature Plasma, Negative Pressure Wound
   Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound
   Healing Mouse Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE wound healing; low-temperature plasma; negative pressure wound therapy;
   bone marrow mesenchymal stem cell; re-epithelialization
ID BLOOD-FLOW; IN-VITRO; EXPRESSION; MURINE; ANGIOGENESIS; REPAIR
AB Low-temperature plasma (LTP; 3 min/day), negative pressure wound therapy (NPWT; 4 h/day), and bone marrow mesenchymal stem cells (MSCs; 1 x 10(6) cells/day) were used as mono- and combination therapy in an acute excisional skin wound-healing ICR mouse model. These therapies have been beneficial in treating wounds. We investigated the effectiveness of monotherapy with LTP, NPWT, and MSC and combination therapy with LTP + MSC, LTP + NPWT, NPWT + MSC, and LTP + NPWT + MSC on skin wounds in mice for seven consecutive days. Gene expression, protein expression, and epithelial thickness were analyzed using real time polymerase chain reaction (RT-qPCR), western blotting, and hematoxylin and eosin staining (H&E), respectively. Wound closure was also evaluated. Wound closure was significantly accelerated in monotherapy groups, whereas more accelerated in combination therapy groups. Tumor necrosis factor-alpha (TNF-alpha) expression was increased in the LTP monotherapy group but decreased in the NPWT, MSC, and combination therapy groups. Expressions of vascular endothelial growth factor (VEGF), alpha -smooth muscle actin (alpha -SMA), and type I collagen were increased in the combination therapy groups. Re-epithelialization was also considerably accelerated in combination therapy groups. Our findings suggest that combination therapy with LPT, NPWT, and MSC exert a synergistic effect on wound healing, representing a promising strategy for the treatment of acute wounds.
C1 [Cui, Hui Song; Park, Ji Heon] Hallym Univ, Burn Inst, Hangang Sacred Heart Hosp, Dept Rehabil Med,Coll Med, Seoul 07247, South Korea.
   [Joo, So Young; Cho, Yoon Soo; Seo, Cheong Hoon] Hallym Univ, Hangang Sacred Heart Hosp, Dept Rehabil Med, Coll Med, Seoul 07247, South Korea.
   [Kim, June-Bum] Hallym Univ, Hangang Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07247, South Korea.
C3 Hallym University; Hallym University; Hallym University
RP Seo, CH (通讯作者)，Hallym Univ, Hangang Sacred Heart Hosp, Dept Rehabil Med, Coll Med, Seoul 07247, South Korea.; Kim, JB (通讯作者)，Hallym Univ, Hangang Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07247, South Korea.
EM bioeast@hanmail.net; anyany98@naver.com; hamays@hanmail.net;
   jiheonpark84@naver.com; hoppdoctor@hanmail.net; chseomd@gmail.com
RI Seo, Cheong Hoon/V-4059-2019; Cho, Yoon Soo/JXL-2899-2024
OI Seo, Cheong Hoon/0000-0003-4091-6382; 
FU Hallym University Research Fund [HURF-2018-55]; Basic Science Research
   Program through the National Research Foundation of Korea (NRF) -
   Ministry of Education [NRF-2017R1D1A1A02018478, 2017R1D1A1B03029731]
FX This research was supported by the Hallym University Research Fund
   (HURF-2018-55) and Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Education
   (NRF-2017R1D1A1A02018478, 2017R1D1A1B03029731).
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NR 44
TC 18
Z9 20
U1 0
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2020
VL 21
IS 10
AR 3675
DI 10.3390/ijms21103675
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LW7GO
UT WOS:000539312100271
PM 32456187
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Matiasek, J
   Domig, KJ
   Djedovic, G
   Babeluk, R
   Assadian, O
AF Matiasek, J.
   Domig, K. J.
   Djedovic, G.
   Babeluk, R.
   Assadian, O.
TI The effect of negative pressure wound therapy with antibacterial
   dressings or antiseptics on an in vitro wound model
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE NPWTi; wound colonisation; silver; polyhexanide; octenidine; negative
   pressure wound therapy
ID ANTIMICROBIAL SOLUTIONS; INSTILLATION; MANAGEMENT; OCTENIDINE; SYSTEM;
   CHLORHEXIDINE; POLIHEXANIDE; IRRIGATION; INFECTIONS; EFFICACY
AB Objective: The aim of this study was to investigate the bacterial bioburden in experimental in vitro wounds during the application of conventional negative pressure wound therapy (NPWT), with and without antimicrobial dressings (polyhexanide, silver), against NPWT instillation of octenidine.
   Method: Experimental wounds produced in an in vitro porcine wound model were homogenously contaminated with bacterial suspension and treated with NPWT and different options. Group A: non-antimicrobial polyurethane foam dressing; group B: antimicrobial polyurethane foam dressing containing silver; group C: antimicrobial gauze dressing containing polyhexanide; group D: non-antimicrobial polyurethane foam dressing intermittently irrigated with octenidine; group E: negative control (non-antimicrobial polyurethane foam dressing without NPWT). Standard biopsies were harvested after 24 and 28 hours.
   Results: This study demonstrated that the use of NPWT with intermitted instillation of octenidine (group D) or application of silver-based polyurethane foam dressings (group B) is significantly superior against Staphylococcus aureus colonisation in experimental wounds compared with non-antimicrobial polyurethane foam dressing (group A) after 48 hours. Surprisingly, the polyhexanide-based dressing (group C) used in this model showed no statistical significant effect compared with the control group (group E) after 24 or 48 hours of treatment.
   Conclusion: Both intermitted instillation of octenidine and silver-based dressings in standard NPWT were significantly superior compared with non-antimicrobial polyurethane foam dressings or PHMB coated gauze dressing after 48 hours.
C1 [Matiasek, J.] St Josef Hosp, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
   [Domig, K. J.] BOKU Univ Nat Resources & Life Sci Vienna, Dept Food Sci & Technol, Vienna, Austria.
   [Djedovic, G.] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, Innsbruck, Austria.
   [Babeluk, R.] Med Univ Vienna, Dept Surg, Vienna, Austria.
   [Assadian, O.] Med Univ Vienna, Dept Hosp Epidemiol & Infect Control, Vienna, Austria.
C3 BOKU University; Medical University of Innsbruck; Medical University of
   Vienna; Medical University of Vienna
RP Matiasek, J (通讯作者)，St Josef Hosp, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
EM office@matiasek.com
RI Assadian, Ojan/H-9753-2019; Domig, Konrad J/A-6877-2019
OI Domig, Konrad J/0000-0003-1090-4284
CR [Anonymous], 2013, 68881200312 BS EN IS
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NR 28
TC 5
Z9 9
U1 0
U2 24
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2017
VL 26
IS 5
BP 236
EP 242
DI 10.12968/jowc.2017.26.5.236
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EU3QD
UT WOS:000400945200005
PM 28475440
DA 2026-07-24
ER

PT J
AU Yu, X
   Xie, P
   Li, JZ
   Cao, L
   Ye, J
AF Yu, Xiang
   Xie, Ping
   Li, Jin-Ze
   Cao, Lei
   Ye, Jin
TI 被撤回的出版物: Effects of negative-pressure wound therapy in the prevention of
   surgical-site wound infection after vascular surgery: A meta-analysis
   (Retracted article. See vol. 21, 2024)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE meta-analysis; negative-pressure wound therapy; vascular surgery; wound
   infection
ID CARE; COMPLICATIONS; REDUCTION; CINPT; TRIAL
AB This meta-analysis systematically evaluates the impact of negative-pressure wound therapy (NPWT) on surgical-site wound infection after vascular surgery. A comprehensive computerized search was conducted, from database inception to November 2023, in PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases for randomized controlled trials (RCTs) on the application of NPWT in vascular surgery. Two researchers independently screened the literature, extracted data, and conducted quality assessments based on inclusion and exclusion criteria. Data analysis was performed using RevMan 5.4 software. A total of 11 RCTs involving 1597 vascular surgery patients were included. The analysis revealed that the application of NPWT in vascular surgery significantly reduced the incidence of wound infections (OR = 0.43, 95% CI: 0.32-0.58, p < 0.001) and complications (OR = 0.40, 95% CI: 0.27-0.58, p < 0.001). Additionally, NPWT was found to decrease the occurrence of both superficial wound infections (OR = 0.63, 95% CI: 0.36-1.12, p = 0.12) and deep wound infections (OR = 0.47, 95% CI: 0.19-1.16, p = 0.10), although these differences were not statistically significant. This study indicates that NPWT, compared with conventional treatment methods, has significant advantages in preventing postoperative wound infections and complications in vascular surgery patients and is therefore worthy of widespread clinical adoption.
C1 [Yu, Xiang; Xie, Ping; Li, Jin-Ze; Cao, Lei] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Radiol, Chengdu, Peoples R China.
   [Yu, Xiang; Xie, Ping; Li, Jin-Ze; Cao, Lei] Chinese Acad Sci, Dept Radiol, Sichuan Translat Med Res Hosp, Chengdu, Peoples R China.
   [Ye, Jin] Sichuan Prov Chengdu Arrays Med Imaging Cooperat, Dept Radiol, Chengdu, Peoples R China.
   [Ye, Jin] Sichuan Prov Chengdu Arrays Med Imaging Cooperat, Dept Radiol, Chengdu 611100, Sichuan, Peoples R China.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Sciences
RP Ye, J (通讯作者)，Sichuan Prov Chengdu Arrays Med Imaging Cooperat, Dept Radiol, Chengdu 611100, Sichuan, Peoples R China.
EM yejin201512@163.com
RI Li, Jinze/LOS-1008-2024
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 43
TC 1
Z9 1
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2024
VL 21
IS 2
AR e14695
DI 10.1111/iwj.14695
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GV3B5
UT WOS:001155397600001
PM 42052881
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Janssen, AH
   Wegdam, JA
   Jaspar, A
   Reilingh, TSD
   Vermeulen, H
   Eskes, AM
AF Janssen, Alexandra H. J.
   Wegdam, Johannes A.
   Jaspar, Alita
   Reilingh, Tammo S. de Vries
   Vermeulen, Hester
   Eskes, Anne M.
TI Patient preference with regard to negative pressure wound therapy and
   participation in wound care: a qualitative study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; patient participation; patient
   preference; quality of life; shared decision-making; wound; wound care;
   wound dressing; wound healing
ID OF-LIFE; DECISION-MAKING; CENTERED CARE; ULCERS; WANT
AB Objective: To explore the experiences and preferences of patients with wounds treated with negative pressure wound therapy (NPWT) regarding shared decision-making and patient participation. Method: Semi-structured interviews were conducted with adult patients treated with NPWT. Interview topics included shared decision-making and patients' active participation in wound treatment. Thematic analysis was applied to identify themes. Results: The interview cohort comprised ten patients. Four themes emerged: (1) Having a wound makes patients uncertain and thus influences their quality of life; (2) NPWT influences patients' daily lives; (3) Patients consider professional treatment decisions most important in the decision-making processes; (4) Self-management of wounds is accepted by patients only for low-complexity and wellhealing wounds under supervision. Participants emphasised their worries about the future and the impact of the wound/treatment on their families. After being thoroughly informed, participants preferred that health professionals decide on the treatment choice. In addition, participants and/or their relatives did not want to actively participate in complex wound care. As well as expressing a need for qualified wound care professionals, participants reported that they did not want to be or feel responsible for the wound treatment. Conclusion: Shared decision-making and active patient participation are underused and underexposed topics in wound care. Patients' recognition of the importance of their personal preferences can facilitate shared decision-making.
C1 [Janssen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
   [Jaspar, Alita] Meander Grp, Home Care Nursing Homes & Residential Care, Landgraaf, Netherlands.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare, Nijmegen, Netherlands.
   [Vermeulen, Hester] HAN Univ Appl Sci, Inst Nursing, Fac Hlth & Social Studies, Nijmegen, Netherlands.
   [Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam Gastroenterol Endocrinol Metab & Amsterd, Amsterdam UMC, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
C3 Radboud University Nijmegen; University of Amsterdam; Menzies Health
   Institute Queensland; Griffith University; Griffith University
RP Janssen, AH (通讯作者)，Elkerliek Hosp, Dept Surg, Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI Janssen, Alexana/0000-0003-1816-0814
CR Amberscript, 2022, Fast and accurate transcripts, ready-made for you
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NR 55
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2025
VL 34
IS 5
BP 340
EP 349
DI 10.12968/jowc.2022.0145
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 2TA8B
UT WOS:001490625500002
PM 40358217
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Piroski, V
   Mueller, E
   Herrmann, E
   Hanisch, E
   Buia, A
AF Piroski, Vladimir
   Mueller, Elisa
   Herrmann, Eva
   Hanisch, Ernst
   Buia, Alexander
TI Reducing Surgical Site Infection by Prophylactic Negative Pressure Wound
   Therapy in a Cohort of General Surgery Patients
SO VISCERAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; Surgical site infection; Simon design
ID PREVENTION; LAPAROTOMY; GUIDELINE; TRIAL; RISK
AB Background: Surgical site infection (SSI) is one of the leading complications in health care. Negative pressure wound therapy (NPWT) is meanwhile widely prophylactically used for preventing SSIs. For evaluating the results of the implantation of this technique, we used the Simon single-arm study design and examine whether NPWT has a prophylactic effect on reducing SSIs in a cohort of general surgery patients. Methods: This single-arm, two-stage study includes 81 elective general surgery patients and corresponds to the Simon's design. The sample size calculation was based on a reduction in the superficial SSI rate from 12 to 4% (power 80%, significance level 5%) using a NPWT system. In compliance with Simon's two-Stage design, the study required the recruitment of 34 patients in stage I and 47 patients in stage II. The two-stage design method would be discarded in case of a wound infection in 3 or more patients in stage I or 6 or more patients in stage II. Using the NPWT system in the operating room, a negative pressure wound dressing was applied post-operatively and removed after 7 days. According to the criteria of the Centres for Disease Control and Prevention (CDC), post-operative wound documentation followed on day 7 and 30. Results: In stage I, no SSI was apparent. In stage II, 3 patients had SSIs (CDC grade I). Conclusion: A prophylactic NPWT can significantly reduce the wound infection rate in elective general surgery.
C1 [Piroski, Vladimir; Hanisch, Ernst; Buia, Alexander] Asklepios Klin Langen, Dept Gen Visceral & Thorac Surg, Langen, Germany.
   [Mueller, Elisa] Goethe Univ Frankfurt, Dept Internal Med, Frankfurt, Germany.
   [Herrmann, Eva] Goethe Univ Frankfurt, Dept Biostat & Math Modeling, Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt
RP Buia, A (通讯作者)，Asklepios Klin Langen, Dept Gen Visceral & Thorac Surg, Langen, Germany.
EM a.buia@t-online.de
RI Herrmann, Eva/E-8215-2010
OI Herrmann, Eva/0000-0002-0662-6675; Buia, Alexander/0000-0002-8090-5453
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   World Health Organization, 2018, Global guidelines for the prevention of surgical site infection, V2nd
NR 34
TC 0
Z9 0
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2022
VL 38
IS 4
BP 272
EP 281
DI 10.1159/000520464
EA JAN 2022
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 3V8DO
UT WOS:000745851000001
PM 36160821
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Tam, SKM
   Nguyen, CL
   Warrier, SK
   Ofri, A
AF Tam, Sze Ki Melanie
   Nguyen, Chu Luan
   Warrier, Sanjay Kumar
   Ofri, Adam
TI Closed incision negative pressure wound therapy in oncoplastic breast
   surgery: A single-centre analysis and literature review
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Review
DE Negative pressure wound therapy; PICO dressing; Oncoplastic breast
   surgery; Wound outcomes
ID RECONSTRUCTION
AB Background: Surgical wound complications cause substantial morbidity. Data on the effectiveness of closed incision negative pressure wound therapy (ciNPWT) as a prophylaxis of surgical wound complications in oncoplastic breast surgery (OPBS) is sparse. This study assessed the routine prophylactic use of ciNPWT in OPBS, explored the trend in outcomes associated with its application and compared subsequent wound outcomes with the existing literature. Method: A single-surgeon retrospective analysis was conducted on OPBS patients from January 2017 to December 2018. Cumulative sum (CUSUM) analysis was adopted to track the trend of wound complication rates over time. Following the exclusion of data potentially skewed by early procedural adaptation, the study compared the remaining cohort's wound complication rates to those reported in current literature. Results: A total of 209 breast wounds post OPBS were included in the analysis. CUSUM analysis revealed a higher rate of complications at the initial phase of ciNPWT implementation, which significantly decreased and plateaued after eleven months, indicating improved outcome (p < 0.001). Complication rates in the first month of ciNPWT introduction were markedly higher than in the subsequent two-year period (p = 0.02) and was omitted from further analysis. The final ciNPWT cohort showed a significantly lower complication rate than standard dressing usage reported in published studies (16.7 % versus 33.9 %, p < 0.001). Conclusion: Adoption of prophylactic ciNPWT resulted in gradual decline of wound complications over time, thus shows significant promise in enhancing wound outcomes post OPBS.
C1 [Tam, Sze Ki Melanie; Nguyen, Chu Luan; Warrier, Sanjay Kumar] Chris OBrien Lifehouse, Dept Breast Surg, Camperdown, NSW 2050, Australia.
   [Nguyen, Chu Luan; Warrier, Sanjay Kumar] Royal Prince Alfred Hosp, Dept Surg, Camperdown, NSW 2050, Australia.
   [Nguyen, Chu Luan; Warrier, Sanjay Kumar; Ofri, Adam] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2050, Australia.
   [Ofri, Adam] Mater Hosp, Breast & Endocrine Dept, Sydney, NSW 2060, Australia.
C3 Chris O'Brien Lifehouse; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; University of Sydney
RP Tam, SKM (通讯作者)，Chris OBrien Lifehouse, Dept Breast Surg, Camperdown, NSW 2050, Australia.
EM skmelanietam@gmail.com
RI ; Ofri, Adam/ABA-8021-2020
OI Warrier, Sanjay/0009-0000-6863-1296; Ofri, Adam/0000-0003-4940-4674;
   Nguyen, Chu Luan/0000-0002-4630-6182
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Agrawal A, 2023, BREAST, V71, P82, DOI 10.1016/j.breast.2023.07.007
   Bolsin S, 2000, INT J QUAL HEALTH C, V12, P433, DOI 10.1093/intqhc/12.5.433
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   Fogacci T, 2020, BREAST J, V26, P1071, DOI 10.1111/tbj.13659
   Gabriel A, 2019, PLAST RECONSTR SURG, V143, p36S, DOI 10.1097/PRS.0000000000005311
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
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   Song JY, 2023, INT WOUND J, V20, P241, DOI 10.1111/iwj.13866
   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
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NR 21
TC 1
Z9 1
U1 0
U2 0
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
EI 2405-5840
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD JUN
PY 2025
VL 23
IS 3
BP 174
EP 179
DI 10.1016/j.surge.2025.01.009
EA MAY 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3KR4S
UT WOS:001502644400008
PM 39934063
OA hybrid
DA 2026-07-24
ER

PT J
AU Liu, H
   Zheng, X
   Chen, L
   Jian, C
   Hu, X
   Zhao, Y
   Li, ZH
   Yu, AX
AF Liu, Hong
   Zheng, Xun
   Chen, Liang
   Jian, Chao
   Hu, Xiang
   Zhao, Yong
   Li, Zonghuan
   Yu, Aixi
TI Negative pressure wound therapy promotes muscle-derived stem cell
   osteogenic differentiation through MAPK pathway
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE osteogenic differentiation; proliferation; muscle-derived stem cells;
   negative pressure wound therapy
ID ACTIVATED PROTEIN-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; OSTEOBLAST
   DIFFERENTIATION; SHEAR-STRESS; BONE; BMP-2; P38; MECHANISMS; FRACTURES;
   REPAIR
AB Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. This article aimed to investigate the effects of NPWT on muscle-derived stem cell (MDSC) osteoblastic differentiation and the related potential mechanism. The cell proliferation rate was substantially increased in NPWT-treated MDSCs in comparison with a static group for 3days. There was no observable effect on the apoptosis of MDSC treated with NPWT compared with the control group for 3days. The expression levels of HIF-1 alpha, BMP-2, COL-I, OST and OPN were increased on days 3, 7 and 14, but the expression level of Runx2 was increased on days 3 and 7 in the NPWT group. Pre-treatment, the specific inhibitors were added into the MDSCs treated with NPWT and the control group. ALP activity and mineralization were reduced by inhibiting the ERK1/2, p38 and JNK pathways. The expression levels of Runx2, COL-I, OST and OPN genes and proteins were also decreased using the specific MAPK pathway inhibitors on days 3, 7 and 14. There were no significant effects on the expression of BMP-2 except on day 3. However, the expressions of the HIF-1 alpha gene and protein slightly increased when the JNK pathway was inhibited. Therefore, NPWT promotes the proliferation and osteogenic differentiation of MDSCs through the MAPK pathway.
C1 [Liu, Hong; Zheng, Xun; Chen, Liang; Jian, Chao; Hu, Xiang; Zhao, Yong; Li, Zonghuan; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Li, ZH; Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan, Hubei, Peoples R China.
EM lizonghuan@whu.edu.cn; yuaixi@whu.edu.cn
RI Liu, Hong/HLQ-6486-2023; Zheng, Xun/JEP-2802-2023
OI Liu, Hong/0000-0002-7534-1710; 
FU National Natural Science Foundation of China [81572163]; Wuhan Huanghe
   Elite Program; Hubei Provence's Outstanding Medical Academic Leader
   Program
FX The work was funded by the National Natural Science Foundation of China
   (Grant no. 81572163), the Wuhan Huanghe Elite Program and the Hubei
   Provence's Outstanding Medical Academic Leader Program. The author
   extends special thanks to Dr. Li Ping for his continuous support and for
   help with this article.
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NR 39
TC 11
Z9 15
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN
PY 2018
VL 22
IS 1
BP 511
EP 520
DI 10.1111/jcmm.13339
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA FR0NQ
UT WOS:000418759200045
PM 28944996
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Seo, J
   Kim, J
   Nam, KA
   Zheng, Z
   Oh, BH
   Chung, KY
AF Seo, Jimyung
   Kim, Jihee
   Nam, Kyoung Ae
   Zheng, Zhenlong
   Oh, Byung Ho
   Chung, Kee Yang
TI Reconstruction of large wounds using a combination of negative pressure
   wound therapy and punch grafting after excision of acral lentiginous
   melanoma on the foot
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE acral lentiginous melanoma; negative pressure wound therapy; punch
   grafting; reconstruction; wounds on the feet
ID SKIN
AB Melanoma in darker-pigmented individuals often develops in an acral lentiginous fashion on the foot. After surgical removal of a tumor at this site, repair of the wound can be challenging. This is because there is an insufficient local skin pool and lack of mobility of the skin in this area. Moreover, functional aspects such as walking and weight bearing should be considered. We performed a combination treatment of negative pressure wound therapy (NPWT) and punch grafting on 15 patients, after wide excision of acral lentiginous melanomas on the foot, and compared these to 26 patients who underwent either secondary intention healing (SIH, n = 13) or NPWT (n = 13) alone. The punch grafting with NPWT group showed significantly shorter healing times than those of the other two groups. Evaluation of completely healed wounds using the Vancouver Burn Scar Assessment Scale revealed that the punch grafting group had mean values better, or comparable, to the SIH or NPWT group in four of the five scales (except pigmentation). As for complications, only one patient developed a wound infection after punch grafting. Further, by utilizing NPWT for fixation of punch grafts, it was possible to treat all subjects as outpatients after punch grafting. These results show that a combination treatment of NPWT and punch grafting is an excellent therapeutic option for post-wide excision wounds on the feet, with significantly shortened healing times and favorable cosmetic outcomes.
C1 [Seo, Jimyung; Kim, Jihee; Nam, Kyoung Ae; Zheng, Zhenlong; Oh, Byung Ho; Chung, Kee Yang] Yonsei Univ, Coll Med, Dept Dermatol, Severance Hosp,Cutaneous Biol Res Inst, Seoul 120752, South Korea.
   [Zheng, Zhenlong] Yanbian Univ, Coll Med, Dept Dermatol, Yanji, Peoples R China.
   [Oh, Byung Ho] Keimyung Univ, Coll Med, Dept Dermatol, Daegu, South Korea.
C3 Yonsei University; Severance Hospital; Yonsei University Health System;
   Yanbian University; Keimyung University
RP Chung, KY (通讯作者)，Yonsei Univ, Coll Med, Dept Dermatol, 50 Yonsei Ro, Seoul 120752, South Korea.
EM kychung@yuhs.ac
RI ; Oh, Byung Ho/HLQ-2899-2023
OI Seo, Jimyung/0000-0003-3416-9990; Oh, Byung Ho/0000-0001-9575-5665; Kim,
   Jihee/0000-0002-0047-5941; Chung, Kee Yang/0000-0003-3257-0297
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT &
   Future Planning [2013R1A2A2A04015894]
FX Statistical assistance was provided by the Biostatistics Collaboration
   Unit, Yonsei University College of Medicine, Seoul, Korea. This research
   was supported by Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Science,
   ICT & Future Planning (No. 2013R1A2A2A04015894).
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NR 23
TC 8
Z9 10
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD JAN
PY 2016
VL 43
IS 1
SI SI
BP 79
EP 84
DI 10.1111/1346-8138.13017
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DB1UT
UT WOS:000368295200014
PM 26173565
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Dynarska, J
   Zagrodnik, E
   Kisielska, A
   Jurczak, A
   Machalowski, T
   Wieder-Huszla, S
AF Dynarska, Jolanta
   Zagrodnik, Edyta
   Kisielska, Agnieszka
   Jurczak, Anna
   Machalowski, Tomasz
   Wieder-Huszla, Sylwia
TI The Use of Larval Debridement Therapy and Negative-Pressure Wound
   Therapy for an Infected Wound After Thyroidectomy-A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE larval debridement therapy; fistula; healing; wound; necrotic tissue;
   wound therapy
ID MAGGOT
AB Background: Larval debridement therapy is used to cleanse necrotic tissue wounds and/or decontaminate wounds that are not amenable to standard therapies. Methods: A patient was diagnosed with septic shock and multiple organ failure caused by Streptococcus pyogenes after thyroidectomy (the patient had experienced contact with a child with scarlet fever six days before admission to the hospital). As a result of systemic infection, numerous necrotic skin lesions appeared, which involved the surgical site, chest and scalp. A tracheocutaneous fistula was confirmed. Due to the ineffectiveness of typical therapy and the patient's severe clinical condition, she qualified for unconventional therapy (larval debridement therapy). Results: Larval wound debridement therapy and negative-pressure wound therapy were used for the tracheocutaneous fistula; this is the first case of this alternative therapy being described in the English-language literature. In this case, based on an analysis of the health benefits for the patient and the uncertain prognosis, larval therapy was used for a postoperative wound after strumectomy with the presence of a tracheocutaneous fistula, and negative-pressure wound therapy ultimately led to complete wound healing. Conclusions: Sepsis caused by Streptococcus pyogenes can be fulminant and often leads to complications or death, especially if it develops in the perioperative period. Larval therapy can be effectively used in cases of fistulas, such as tracheocutaneous fistulas, to prepare the wound bed for the next stage of healing using negative-pressure therapy, which ultimately leads to complete wound healing.
C1 [Dynarska, Jolanta; Kisielska, Agnieszka] Med Ctr Jolanta Dynarska, PL-70953 Szczecin, Poland.
   [Zagrodnik, Edyta] Pomeranian Med Univ, Clin Dept Anesthesiol & Intens Care Adults & Child, PL-71252 Szczecin, Poland.
   [Jurczak, Anna; Wieder-Huszla, Sylwia] Pomeranian Med Univ, Dept Specialized Nursing, PL-71210 Szczecin, Poland.
   [Machalowski, Tomasz] Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, PL-71252 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Zagrodnik, E (通讯作者)，Pomeranian Med Univ, Clin Dept Anesthesiol & Intens Care Adults & Child, PL-71252 Szczecin, Poland.; Machalowski, T (通讯作者)，Pomeranian Med Univ, Dept Perinatol Obstet & Gynecol, PL-71252 Szczecin, Poland.
EM rejestracja@dynarska-centrum.pl; edyta.zagrodnik@pum.edu.pl;
   szpital@onkologia.szczecin.pl; anna.jurczak@pum.edu.pl;
   tomasz.machalowski@pum.edu.pl; sylwia.wieder.huszla@pum.edu.pl
RI Huszla, Sylwia/GQR-0700-2022; Jurczak, Anna/K-8913-2014; Machałowski,
   Tomasz/MDT-3268-2025
OI Jurczak, Anna/0000-0003-1935-5285; Kisielska, Agnieszka
   Katarzyna/0009-0002-0649-7575; Machałowski, Tomasz/0000-0001-6595-8250
CR Bazalinski D, 2024, J CLIN MED, V13, DOI 10.3390/jcm13030884
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG 9
PY 2025
VL 14
IS 16
AR 5634
DI 10.3390/jcm14165634
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6NV6L
UT WOS:001557798800001
PM 40869460
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Fout, B
   Plotzke, M
AF Fout, Betty
   Plotzke, Michael
TI Comparing Traditional and Disposable Negative-Pressure Wound Therapy Use
   by Medicare Home Health Patients
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE disposable; home health; Medicare; negative-pressure wound therapy;
   NPWT; traditional; wound care
AB OBJECTIVESince 2017, home health agencies (HHAs) have received reimbursement for the provision of negative-pressure wound therapy (NPWT) using disposable, portable devices to eligible Medicare fee-for-service beneficiaries. This study aimed to describe the use of disposable NPWT (dNPWT) versus traditional, durable medical equipment-based NPWT (tNPWT) in the home health setting over time and compare the types of beneficiaries using and associated Medicare payments for NPWT separate from the home health payment bundle.METHODSMedicare fee-for-service claims were used to identify beneficiaries receiving NPWT from HHAs during home health stays. Assessment and Medicare administrative data were linked to compare characteristics between those receiving tNPWT or dNPWT and to calculate and contrast average Medicare payments for NPWT provided during the home health episode.RESULTSIn 2019, the vast majority of NPWT used was tNPWT (>99%). Beneficiaries using dNPWT had fewer health risk factors and used substantially less medical care than beneficiaries using tNPWT ($47,187 vs $60,440 in annual total Medicare payments per beneficiary). However, the average Medicare payments for dNPWT exceeded that of tNPWT ($1,624 vs $899) during a home health episode.CONCLUSIONSAlthough dNPWT is well-suited for the home, its uptake has been slow. This may be attributable to HHAs' confusion in billing for dNPWT or differences in the wound types appropriate for dNPWT versus tNPWT. Policymakers should continue to monitor the use of dNPWT in the home health setting, especially given the greater average Medicare payment of dNPWT per episode.
CR [Anonymous], 2017, GAO-17-600
   [Anonymous], 2019, Home Health Services Payment System
   [Anonymous], 2019, Clarification of Billing and Payment Policies for Negative Pressure Wound Therapy (NPWT) Using a Disposable Device
   Banasiewcz T., 2019, WOUNDS INT, V10
   Centers for Medicare & Medicaid Services, 2021, DMEPOS FEE SCHED
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   Intermountain Healthcare, 2018, NEG PRESS WOUND THER
   Medicare Hospital Outpatient Prospective Payment System, 2019, ADD A ADD B UPD
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   Schaum K., 2019, WATER AIR SOIL POLL, V32
   US Government Accountability Office, 2019, MED SPEND CERT DISP
   Wound Care Centers, NEG PRESS WOUND THER
NR 16
TC 4
Z9 4
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2022
VL 35
IS 1
BP 37
EP 42
DI 10.1097/01.ASW.0000801536.61163.e5
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 8W7IY
UT WOS:000931502800010
PM 34935720
DA 2026-07-24
ER

PT J
AU Stanciu, CT
   Vaduva, MMB
   Pop, DL
   Vermesan, D
AF Stanciu, Cristina-Teodora
   Vaduva, Marcel Mihai Berceanu
   Pop, Daniel Laurentiu
   Vermesan, Dinu
TI Enhancing Quality of Life in Patients with Acute Wounds: The Synergistic
   Effects of Negative Pressure Wound Therapy and Physiotherapy
SO BIOMEDICINES
LA English
DT Article
DE negative pressure wound therapy; rehabilitation; quality of life; edema
   reduction; functional recovery
ID COGNITIVE REHABILITATION; SF-36
AB Background and Objectives: Negative Pressure Wound Therapy (NPWT) is widely used in acute wound management, promoting tissue regeneration and edema reduction. However, the effects of integrating physiotherapy on functional recovery and quality of life remain underexplored. This study assesses the combined impact of NPWT and physiotherapy on functional and clinical outcomes in patients with acute wounds at the Timisoara County Emergency Clinical Hospital. Methods: This cross-sectional study included 205 patients divided into two groups: NPWT-only (n = 110) and NPWT plus physiotherapy (n = 95). Clinical and functional parameters, including joint mobility, edema, and pain, were assessed at baseline, ten days, six weeks, and six months. Quality of life and mental health were evaluated using WHOQOL-BREF, SF-36, VAS, and HADS questionnaires. Results: Compared to NPWT alone, the NPWT + physiotherapy group showed at discharge greater edema reduction (40.58 +/- 2.48 vs. 41.15 +/- 2.39), improved joint mobility (14.22 +/- 1.66 degrees vs. 10.05 +/- 1.76 degrees, p < 0.05), and a more significant pain decrease (VAS reduction to 5.68 +/- 1.13 vs. 6.7 +/- 1.05, p < 0.001). Quality of life scores improved notably, with higher WHOQOL-BREF (59.89 +/- 5.86 vs. 66.64 +/- 6.24, p < 0.001) and HADS psychological scores (p < 0.001). Conclusions: Combining NPWT with physiotherapy enhances functional recovery, reduces pain and anxiety, and improves quality of life. These findings support a multidisciplinary approach in acute wound management.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch, Timisoara 300041, Romania.
   [Vaduva, Marcel Mihai Berceanu; Pop, Daniel Laurentiu; Vermesan, Dinu] Victor Babes Univ Med & Pharm Timisoara, Orthoped Traumatol Urol Radiol & Med Imaging Dept, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara
RP Vaduva, MMB (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Orthoped Traumatol Urol Radiol & Med Imaging Dept, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; marcel.berceanu-vaduva@umft.ro;
   daniellaurentiupop@yahoo.com; dinu@vermesan.ro
FU Victor Babes University of Medicine and Pharmacy; Victor Babes
   University of Medicine and Pharmacy for paying the APC
FX We acknowledge the Victor Babes University of Medicine and Pharmacy for
   paying the APC.
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NR 37
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR 24
PY 2025
VL 13
IS 4
AR 785
DI 10.3390/biomedicines13040785
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 1ZV9X
UT WOS:001477587100001
PM 40299354
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Awad, SS
   Stern, JD
   Milne, CT
   Dowling, SG
   Sotomayor, R
   Ayello, EA
   Aguirre, LJF
   Khalaf, BZ
   Gould, LJ
   Desvigne, MN
   Chaffin, AE
AF Awad, Samir S.
   Stern, James D.
   Milne, Cathy T.
   Dowling, Shane G.
   Sotomayor, Ron
   Ayello, Elizabeth A.
   Aguirre, Leandro J. Feo
   Khalaf, Basil Z.
   Gould, Lisa J.
   Desvigne, Michael N.
   Chaffin, Abigail E.
TI Surgical Reconstruction of Stage 3 and 4 Pressure Injuries: A Literature
   Review and Proposed Algorithm from an Interprofessional Working Group
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Review
DE bioscaffold; negative-pressure wound therapy; ovine forestomach matrix;
   pressure injury; surgical reconstruction
ID PORCINE EXTRACELLULAR-MATRIX; URINARY-BLADDER MATRIX; QUALITY-OF-LIFE;
   PLACENTAL MEMBRANE; CLINICAL-OUTCOMES; WOUND THERAPY; DEAD SPACE; ULCER;
   FLAP; MANAGEMENT
AB OBJECTIVEStage 3 and 4 pressure injuries (PIs) present an enormous societal burden with no clearly defined interventions for surgical reconstruction. The authors sought to assess, via literature review and a reflection/evaluation of their own clinical practice experience (where applicable), the current limitations to the surgical intervention of stage 3 or 4 PIs and propose an algorithm for surgical reconstruction.METHODSAn interprofessional working group convened to review and assess the scientific literature and propose an algorithm for clinical practice. Data compiled from the literature and a comparison of institutional management were used to develop an algorithm for the surgical reconstruction of stage 3 and 4 PIs with adjunctive use of negative-pressure wound therapy and bioscaffolds.RESULTSSurgical reconstruction of PI has relatively high complication rates. The use of negative-pressure wound therapy as adjunctive therapy is beneficial and widespread, leading to reduced dressing change frequency. The evidence for the use of bioscaffolds both in standard wound care and as an adjunct to surgical reconstruction of PI is limited. The proposed algorithm aims to reduce complications typically seen with this patient cohort and improve patient outcomes from surgical intervention.CONCLUSIONSThe working group has proposed a surgical algorithm for stage 3 and 4 PI reconstruction. The algorithm will be validated and refined through additional clinical research.
C1 [Awad, Samir S.] Baylor Coll Med, Surg, Houston, TX 77030 USA.
   [Awad, Samir S.] Michael E DeBakey VA Med Ctr, Surg, Houston, TX 77030 USA.
   [Stern, James D.] Mem Reg Hosp, Hollywood, FL USA.
   [Milne, Cathy T.] Connecticut Clin Nursing Associates, Bristol, CT USA.
   [Dowling, Shane G.] Aroa Biosurg Ltd, Auckland, New Zealand.
   [Sotomayor, Ron] Advent Hlth, Orlando, FL USA.
   [Ayello, Elizabeth A.] Ayello Harris & Associates Inc, Copake, NY USA.
   [Aguirre, Leandro J. Feo] Palm Beach Hlth Network, Del Ray Beach, FL USA.
   [Khalaf, Basil Z.] MEDIKAL Grp, Houston, TX USA.
   [Gould, Lisa J.] South Shore Hlth, Weymouth, MA USA.
   [Desvigne, Michael N.] Desvigne Plast Surg & Abrazo Hlth, Scottsdale, AZ USA.
   [Chaffin, Abigail E.] Tulane Univ, Div Plast Surg, New Orleans, LA USA.
   [Chaffin, Abigail E.] MedCentris Wound Healing Inst, New Orleans, LA USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital; Adventist Health Services; AdventHealth;
   (AdventHealth) Central Florida Division; Central Florida Hospital -
   South; AdventHealth Orlando; Tulane University
RP Awad, SS (通讯作者)，Baylor Coll Med, Surg, Houston, TX 77030 USA.; Awad, SS (通讯作者)，Michael E DeBakey VA Med Ctr, Surg, Houston, TX 77030 USA.
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NR 110
TC 8
Z9 9
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2023
VL 36
IS 5
BP 249
EP 258
DI 10.1097/01.ASW.0000922708.95424.88
PG 10
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA E9PY6
UT WOS:000978787400007
PM 37079788
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Zhou, JQ
   Yu, JJ
   Hu, TS
   Li, JY
   Ding, CC
   Chen, LH
   Zhang, M
AF Zhou, Jiaqi
   Yu, Jingjing
   Hu, Tianshuo
   Li, Jingyi
   Ding, Cuicui
   Chen, Lihui
   Zhang, Min
TI Nanosheets doped collagen-based composite sponge dressing with
   integrated negative pressure wound therapy, photothermal, and gas
   therapies for wound healing
SO BIOMATERIALS ADVANCES
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Photothermal therapy (PTT);
   Polyvinyl alcohol (PVA); Sponge dressing; Photothermal antibacterial
ID OXIDE
AB Polyvinyl alcohol (PVA) sponges are widely utilized as wound dressings, yet they face limitations in clinical practice, particularly in addressing bacterial infection. Herein, a multifunctional composite sponge dressing is developed by incorporating collagen (COL) and a graphene oxide (GO)/BNN6 (a nitric oxide (NO) donor) assembly into a PVA matrix. The resulting GO/BNN6/PVA/COL composite sponge exhibits a three-dimensional porous network, high porosity, excellent liquid absorption, and favorable shape retention. Benefiting from these features, the composite sponge demonstrates efficient negative pressure drainage performance in vitro, achieving a drainage flux of 3515.0 mL center dot s- 1 center dot m- 2 at 16 kPa, indicating its potential applicability for negative pressure wound therapy (NPWT). Moreover, under near-infrared (NIR) irradiation, GO provides significant photothermal conversion, allowing the sponge to serve as a photothermal therapy (PTT) agent. The localized heat simultaneously triggers the controlled release of NO from BNN6, yielding a combined photothermal and NO-mediated antibacterial effect with inhibition rates exceeding 96% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Notably, in vivo experiments demonstrate that the GO/BNN6/PVA/COL sponge under NIR irradiation effectively suppresses infection, accelerates wound closure, and promotes granulation tissue formation and skin regeneration. This work presents a versatile sponge dressing that combines the key functions required for NPWT, on-demand PTT, and gas-based antibacterial treatment, demonstrating promising potential for advanced wound management.
C1 [Zhou, Jiaqi; Hu, Tianshuo; Chen, Lihui; Zhang, Min] Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.
   [Yu, Jingjing; Ding, Cuicui] Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
   [Li, Jingyi] Fujian Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Fuzhou 350122, Peoples R China.
   [Zhang, Min] Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
C3 Fujian Agriculture & Forestry University; Fujian University of
   Technology; Fujian Medical University
RP Zhang, M (通讯作者)，Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.; Ding, CC (通讯作者)，Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
EM dingcuicui.1124@163.com; mzhang@fafu.edu.cn
RI ; Chen, lihui/IXD-5425-2023
OI Chen, Li Hui/0009-0002-9978-9509; 
FU National Natural Science Foundation of China [22178056]; Outstanding
   Youth Natural Science Foundation of Fujian Province [2024J09047]; Major
   science and technology projects of Fujian Province [2023YZ038001];
   Fuzhou Science and Technology Major Project [2023-ZD-008]
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant No. 22178056) , Outstanding Youth Natural
   Science Foundation of Fujian Province (Grant No. 2024J09047) , Major
   science and technology projects of Fujian Province (Grant No.
   2023YZ038001) , and Fuzhou Science and Technology Major Project
   (2023-ZD-008) .
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NR 56
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2772-9508
J9 BIOMATER ADV
JI Biomater. Adv.
PD SEP
PY 2026
VL 186
AR 214942
DI 10.1016/j.bioadv.2026.214942
EA MAY 2026
PG 12
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA IR9YF
UT WOS:001778925100001
PM 42150292
DA 2026-07-24
ER

PT J
AU Lindsay, R
   McCarthy, CH
   Lin, JR
   Nherera, L
   Murdoch, JM
AF Lindsay, Rodney
   McCarthy, Catherine H.
   Lin, Jiunn-Ru (Angela)
   Nherera, Leo
   Murdoch, Julie M.
TI From Traditional to Single Use: The Evolution of Negative Pressure Wound
   Therapy as a Mechanism for Optimal Wound Management
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE traditional negative pressure wound therapy; device; single-use negative
   pressure wound; therapy device; acute wounds; chronic wounds; wound
   clinics
ID CONSENSUS PANEL RECOMMENDATIONS
AB Background. The safety and efficacy of negative pressure wound therapy (NPWT) is well established. The technology has evolved to include 2 device categories: traditional NPWT (tNPWT) and single-use NPWT (sNPWT). Each mode has unique properties benefitting multiple aspects of wound care. Objective. To assess the proportion of tNPWT-treated wounds that could be amenable to sNPWT, thus determining optimal therapy. Materials and Methods. A de-identified dataset of wounds managed with tNPWT in outpatient clinics in the United States from 2006 through 2020 was analyzed to determine the proportion of wounds that could have been managed with sNPWT based on wound area, depth, and exudate volume, as well as sNPWT dressing size. Descriptive statistics were reported. Results. A total of 5040 wounds were analyzed. Ten wound types were identified, the most prevalent being surgical open wound (n = 2268 [45%]). All 8 commercially available sNPWT device dressing sizes, from 1 manufacturer, were included in the analysis. Overall, 3403 wounds (68%) would have been suitable to receive sNPWT instead of tNPWT at treatment commencement. Conclusion. The utilization of tNPWT is ideally positioned for large, deep, highly exuding wounds. However, by assessing a wound's dimensions and exudate volume and type, a more appropriate NPWT device selection can be made; thus, ensuring the delivery of therapy with the most suitable device modality appropriate for the wound and patient while also maximizing resources.
C1 [Lindsay, Rodney] Carrollton Reg Med Ctr, Comprehens Wound Ctr, Carrollton, TX USA.
   [McCarthy, Catherine H.; Murdoch, Julie M.] Smith & Nephew, Global Clin & Med Affairs, Bldg 5,Hatters Lane,Croxley Pk, Watford WD18 8YE, England.
   [Lin, Jiunn-Ru (Angela); Nherera, Leo] Smith & Nephew, Hlth Econ & Outcomes Res Data Analyt, Ft Worth, TX USA.
C3 Smith & Nephew
RP Murdoch, JM (通讯作者)，Smith & Nephew, Global Clin & Med Affairs, Bldg 5,Hatters Lane,Croxley Pk, Watford WD18 8YE, England.
EM Julie.Murdoch@smith-nephew.com
CR Adeyemi A, 2018, WOUNDS, V30, pE13
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NR 15
TC 1
Z9 1
U1 2
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2025
VL 37
IS 3
BP 125
EP 133
DI 10.25270/wnds/24078
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 1YJ9N
UT WOS:001476594100005
PM 40215363
DA 2026-07-24
ER

PT J
AU Lee, DY
   Eo, S
   Lim, S
   Yoon, JS
AF Lee, Dong Yun
   Eo, SuRak
   Lim, SooA
   Yoon, Jung Soo
TI Successful pedicled vertical rectus abdominis myocutaneous flap
   reconstruction with negative-pressure wound therapy for deep sternal
   wound infection: a case report and comprehensive review
SO FRONTIERS IN SURGERY
LA English
DT Review
DE vertical rectus abdominis myocutaneous (VRAM) flap; deep sternal wound
   infection (DSWI); negative-pressure wound therapy (NPWT); cardiac
   injury; case report
ID CARDIAC-SURGERY; PREVENTION; STERNOTOMY
AB IntroductionDeep sternal wound infection (DSWI) is a serious complication that may occur after median sternotomy, with potentially devastating consequences. By reporting our case and analyzing the existing literature, this article aimed to provide a thorough understanding of the role of negative-pressure wound therapy (NPWT) and the importance of flap choice in managing DSWI accompanied by severe heart injury and high hemodynamic risk.Case descriptionA 60-year-old woman with severe aortic stenosis, aortic valve regurgitation, and heart failure underwent redo sternotomy, which resulted in an intraoperative right ventricle injury. She required extracorporeal membrane oxygenation support because of low blood pressure and subsequently developed complications, including surgical site hematoma, wound dehiscence, and fat necrosis. She was referred for wound closure, where a significant 10 x 20-cm soft tissue defect in the anterior chest wall was observed. A pedicled vertical rectus abdominis myocutaneous flap addressed the soft tissue defect. The wound showed remarkable improvement at the 8-month follow-up visit.ConclusionsDSWI management is a complex and multifaceted challenge. NPWT, when combined with appropriate surgical strategies, including wound debridement and flap selection, may promote successful wound healing. This case report highlights the successful management of a complex DSWI using a multidisciplinary approach, including debridement, appropriate antibiotic therapy, and free-flap reconstruction, which resulted in favorable outcomes.
C1 [Lee, Dong Yun; Eo, SuRak; Lim, SooA; Yoon, Jung Soo] DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea.
C3 Dongguk University
RP Yoon, JS (通讯作者)，DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea.
EM crsboys@naver.com
RI ; Eo, SuRak/JXM-4124-2024; Lee, Dong Yun/QPA-1583-2026
OI Yoon, Jung Soo/0000-0003-2462-5702; Lee, Dong Yun/0000-0002-5323-6469
FU The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
FX No Statement Available
CR Abu-Omar Y, 2017, EUR J CARDIO-THORAC, V51, P10, DOI 10.1093/ejcts/ezw326
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NR 12
TC 1
Z9 3
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 6
PY 2023
VL 10
AR 1268555
DI 10.3389/fsurg.2023.1268555
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP1I2
UT WOS:001119571000001
PM 38026493
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU van der Valk, MJM
   de Graaf, EJR
   Doornebosch, PG
   Vermaas, M
AF van der Valk, Maxime J. M.
   de Graaf, Eelco J. R.
   Doornebosch, Pascal G.
   Vermaas, Maarten
TI Incisional Negative-Pressure Wound Therapy for Perineal Wounds After
   Abdominoperineal Resection for Rectal Cancer, a Pilot Study
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE incisional negative-pressure wound therapy; abdominoperineal resection;
   rectal cancer
ID SURGICAL INCISIONS; MANAGEMENT-SYSTEM; RISK-FACTORS; COMPLICATIONS;
   SURGERY; CLOSURE; DEVICE; COHORT
AB Objective: Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR.
   Approach: A new single-use incisional negative-pressure therapy device was applied in 10 patients. A negative pressure of -80mmHg was continued for 7 days postsurgery. Incidence of wound complications and time to wound healing were compared with a historical control group of 10 patients undergoing APR in 2014, treated with conventional wound care.
   Results: Patient characteristics were comparable in both groups. Mean 1.6 dressings were used per patient. A wound complication was diagnosed in seven patients versus six in the control group. Wound infections were diagnosed median 11.5 days after surgery, compared with 10.5 days in the control group. Duration of wound healing was shorter in the study group (median 8.5 weeks vs. 13 weeks).
   Innovation: This is the first study to report on the use of this iNPWT device for patients who underwent APR for rectal cancer.
   Conclusion: In this study, iNPWT did not reduce wound complications. Wound infections occurred slightly later and seemed to have a less severe clinical course. After treatment with iNPWT, the duration of wound healing was shorter.
C1 [van der Valk, Maxime J. M.; de Graaf, Eelco J. R.; Doornebosch, Pascal G.; Vermaas, Maarten] IJsselland Hosp, Dept Surg, Capelle aan den IJssel, Netherlands.
   [van der Valk, Maxime J. M.] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC
RP van der Valk, MJM (通讯作者)，IJsselland Hosp, Dept Surg, Prins Constantijnweg 2, NL-2906 ZC Capelle aan den IJssel, Netherlands.
EM mvandervalk@lumc.nl
RI van der valk, marc/AAQ-9026-2020
CR Althumairi AA, 2016, WORLD J SURG, V40, P1755, DOI 10.1007/s00268-016-3450-0
   Artioukh DY, 2007, COLORECTAL DIS, V9, P362, DOI 10.1111/j.1463-1318.2006.01159.x
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   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
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   Hudson DA, 2015, INT WOUND J, V12, P195, DOI 10.1111/iwj.12080
   Hurd T, 2014, OSTOMY WOUND MANAG, V60, P30
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   Pellino G, 2014, SURG INNOV, V21, P204, DOI 10.1177/1553350613496906
   Selvaggi Francesco, 2014, Surg Technol Int, V24, P83
   Sumrien H, 2016, TECH COLOPROCTOL, V20, P627, DOI 10.1007/s10151-016-1495-6
   Vermaas M, 2005, EJSO-EUR J SURG ONC, V31, P1000, DOI 10.1016/j.ejso.2005.02.004
   Wiatrek Rebecca L, 2008, Clin Colon Rectal Surg, V21, P76, DOI 10.1055/s-2008-1055325
NR 18
TC 18
Z9 19
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC
PY 2017
VL 6
IS 12
BP 425
EP 429
DI 10.1089/wound.2017.0749
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FP8HQ
UT WOS:000417883800004
PM 29279806
DA 2026-07-24
ER

PT J
AU Ryu, JY
   Lee, JH
   Kim, JS
   Lee, JS
   Lee, JW
   Choi, KY
   Chung, HY
   Cho, BC
   Yang, JD
AF Ryu, Jeong Yeop
   Lee, Jung Ho
   Kim, Jong Seong
   Lee, Joon Seok
   Lee, Jeong Woo
   Choi, Kang Young
   Chung, Ho Yun
   Cho, Byung Chae
   Yang, Jung Dug
TI Usefulness of Incisional Negative Pressure Wound Therapy for Decreasing
   Wound Complication Rates and Seroma Formation Following Prepectoral
   Breast Reconstruction
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Mammaplasty; Breast implants
AB Background Seroma is a common complication in prepectoral breast reconstruction. PICOTM dressing, a type of incisional negative pressure wound therapy (iNPWT), was used to reduce complications postoperatively.
   Methods This study was a retrospective cohort study that included patients who underwent prepectoral breast reconstruction between February 2017 and July 2019. There were two groups: one that received PICOTM dressing and a control group. The frequencies of overall complications, major seromas, and reoperations were analyzed. The durations and total amounts of seromas were also analyzed.
   Result Sixty patients were included in this study (PICOTM : 37 and non-PICOTM patients: 23). The overall incidence of complications, major seromas, and frequency of reoperations were lower in the PICO group compared to the non-PICOTM group (18.9% vs. 52.2%, p = 0.007; 16.2% vs. 43.5%, p = 0.020; 2.7% vs. 26.1%, p = 0.006, respectively). Univariate analysis was used to analyze the risk factors for complications due to the application of PICOTM dressing and showed statistically significant results for any complication. When univariate analysis was performed on risk factors for seroma, the duration of seroma showed statistical significance in association with PICOTM dressing status and mastectomy volume. The total number of patients who developed seroma was statistically correlated with age, PICOTM dressing status, and mastectomy volume.
   Conclusions PICOTM dressing after prepectoral breast reconstruction could be a useful tool for reducing the frequency of complications and major seroma, as well as the duration and total incidences of seroma.
C1 [Ryu, Jeong Yeop; Lee, Jung Ho; Kim, Jong Seong; Lee, Joon Seok; Lee, Jeong Woo; Choi, Kang Young; Chung, Ho Yun; Cho, Byung Chae; Yang, Jung Dug] Kyungpook Natl Univ, Dept Plast & Reconstruct Surg, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
C3 Kyungpook National University (KNU)
RP Yang, JD (通讯作者)，Kyungpook Natl Univ, Dept Plast & Reconstruct Surg, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
EM lambyang@knu.ac.kr
RI ; Ryu, Jeong Yeop/GLQ-9419-2022; Yang, Jung/R-7806-2019
OI Kim, Jong Seong/0000-0002-4725-9277; Lee, Jeong Woo/0000-0003-4903-6066;
   Ryu, Jeong Yeop/0000-0003-2812-5051; 
CR Abbate O, 2020, BREAST CANCER RES TR, V182, P543, DOI 10.1007/s10549-020-05722-2
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Elswick SM, 2018, PLAST RECONSTR SURG, V142, P1, DOI 10.1097/PRS.0000000000004453
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   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Highton L, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001488
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   Jafferbhoy S, 2017, GLAND SURG, V6, P682, DOI 10.21037/gs.2017.07.07
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   Lee JS, 2019, GLAND SURG, V8, P748, DOI 10.21037/gs.2019.12.10
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 18
TC 16
Z9 19
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD APR
PY 2022
VL 46
IS 2
BP 633
EP 641
DI 10.1007/s00266-020-02115-0
EA JAN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1C9IU
UT WOS:000609047700002
PM 33474573
DA 2026-07-24
ER

PT J
AU Zhu, YP
   Zhang, XZ
   Zhang, YF
   Zhong, XJ
   Lu, XY
   Zhai, YR
AF Zhu, Yaping
   Zhang, Xiuzhen
   Zhang, Yufan
   Zhong, Xiaojuan
   Lu, Xiangyue
   Zhai, Yanrong
TI Nonsurgical Management of Pressure Injury With a New Silicone Rubber
   Negative Pressure Wound Therapy With Instillation Device: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; silicone rubber; anti-blocking negative
   pressure drainage tube with instillation; catheter obstruction; negative
   pressure wound therapy; pressure injury; silicone rubber
ID DWELL TIME; HOLES
AB Background. Surgical debridement and flap-based reconstruction are essential procedures for managing stage 3 and 4 pressure injuries (PIs). However, the recurrence of PIs after flap reconstruction is high; moreover, many patients cannot tolerate surgical management. Case Report. An 81-year-old male presented with 3 stage 4 PIs (1 each on the sacral region and heels) that were successfully treated without surgical management. The patient was bedridden with progressive dementia, pneumonia, and malnutrition. He could not tolerate thorough debridement. A new silicone rubber negative pressure drainage tube with instillation device was applied to the wounds on the right heel, left heel, and sacral region for 20, 25, and 80 days, respectively, until the wounds were filled with healthy granulation tissue. This device comprises a principal, a connector, an instillation, and a negative pressure drainage tube. The principal part of the device is made of medical-grade silicone rubber shaped into a columnar structure; there is also an instillation channel in the center of the principal tube, forming an instillation loop and ensuring the whole wound is thoroughly instilled. The wounds treated in this case healed without thorough debridement or flap-based reconstruction and had not recurred as of 1-year follow-up. Conclusion. Wound healing was achieved without thorough debridement or flap reconstruction, using a new silicone rubber anti-blocking negative pressure wound therapy with instillation device that was able to remove thick exudate and slough.
C1 [Zhu, Yaping; Zhang, Xiuzhen; Zhang, Yufan; Zhong, Xiaojuan; Lu, Xiangyue; Zhai, Yanrong] Suzhou Wuzhong Peoples Hosp, Dept Gastroenterol, Soochow North Rd 61, Suzhou 215128, Jiangsu, Peoples R China.
RP Zhai, YR (通讯作者)，Suzhou Wuzhong Peoples Hosp, Dept Gastroenterol, Soochow North Rd 61, Suzhou 215128, Jiangsu, Peoples R China.
EM zhaiyanrong1885@126.com
FU Science and Technology Innovation Plan of Suzhou [SKY2022033]
FX This work was supported by Science and Technology Innovation Plan of
   Suzhou (SKY2022033) . The authors disclose no other conflicts of
   interest.
CR [Anonymous], 2021, Wound Repair Regen, V29, P20, DOI [10.1111/wrr.12863, DOI 10.1111/WRR.12863]
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   Fernández LG, 2020, WOUNDS, V32, P279
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   Jaul E, 2015, INT WOUND J, V12, P254, DOI 10.1111/iwj.12086
   Jin YS, 2023, INT J SURG CASE REP, V105, DOI 10.1016/j.ijscr.2023.108008
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   Norman G, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012032.pub3
   Pan N F, 2022, Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, V38, P1156, DOI 10.3760/cma.j.cn501225-20220228-00041
   Sahin E, J
   Scarpa C, 2024, WOUNDS, V36, P67, DOI 10.25270/wnds/23081
   Shi JY, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011334.pub3
   Song YP, 2019, INT WOUND J, V16, P1533, DOI 10.1111/iwj.13243
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Yu L, 2023, INT WOUND J, V20, P3371, DOI 10.1111/iwj.14169
   Zhao Y, 2023, INT WOUND J, V20, P4253, DOI 10.1111/iwj.14327
NR 18
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2025
VL 37
IS 1
BP 8
EP 12
DI 10.25270/wnds/24080
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0M4E
UT WOS:001429174500003
PM 39982384
DA 2026-07-24
ER

PT J
AU Xing, YH
   Hou, YL
   Li, C
   Wang, WF
   Fu, CJ
   Tang, L
AF Xing, Yihui
   Hou, Yali
   Li, Cui
   Wang, Weifeng
   Fu, Chongjian
   Tang, Lu
TI Analgesic effect of premixed nitrous oxide/oxygen on removal of vacuum
   assisted closure dressings: randomized controlled trial study protocol
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Nitrous oxide; Analgesia; Vacuum assisted closure; Procedure pain
ID PRESSURE WOUND THERAPY; DOUBLE-BLIND; PAIN; LIDOCAINE; SEDATION;
   QUALITY; IMPACT
AB BackgroundVacuum assisted closure (VAC) is an effective treatment that promotes wound healing in clinical practice. However, the pain caused by Vacuum assisted closure VAC dressing removal is still a challenge for patients and medical staff. The purpose of this study was to investigate the analgesic effect and safety of premixed nitrous oxide/oxygen in the treatment of pain caused by VAC dressing removal.Methods/designThis study is a single center, randomized, placebo-controlled, double-blind clinical trial. A total of 100 patients requiring VAC dressing removal were recruited and randomly divided into an intervention group and a control group. The intervention group will receive routine treatment plus a premixed nitrous oxide/oxygen mixture, and the control group will receive routine treatment plus oxygen. Participants and researchers are all blind to the operation process. The results of each group will be monitored at baseline (T0), 5 min after intervention (T1), and 5 min after finishing intervention (T2), 15 min after finishing intervention (T3). The primary outcome measure was pain intensity. Secondary outcomes included physiological parameters, adverse reactions, operators, and patients' satisfaction.DiscussionThis study will explore the analgesic effect of oxide/oxygen mixture on VAC dressing removal. If it is beneficial to patients with VAC dressing change, it will be helpful for pain management of VAC dressing removal.Trial registrationChinese Clinical Trial Register ChiCTR2200056742. Registered on February 13, 2022.
C1 [Xing, Yihui; Wang, Weifeng; Fu, Chongjian; Tang, Lu] 960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
   [Xing, Yihui] Qingdao Stomatol Hosp, Qingdao, Peoples R China.
   [Hou, Yali] Shandong First Med Univ, Shandong Prov Hosp, Dept Stomatol, Jinan, Peoples R China.
   [Li, Cui] 960th Hosp PLA, Dept Rehabil, Jinan, Peoples R China.
   [Wang, Weifeng] Weifang Med Univ, Sch Nursing, Weifang, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong Second Medical University
RP Fu, CJ; Tang, L (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
EM william68112002@aliyun.com; tanglu_office@163.com
RI wang, weifeng/N-4140-2013
FU Science and technology development project of Affiliated Hospital of
   Weifang Medical University
FX We thank our colleagues for their contributions in this experiment.
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NR 39
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD MAR 4
PY 2025
VL 20
IS 1
AR 231
DI 10.1186/s13018-024-05397-1
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z5Z6V
UT WOS:001439687900004
PM 40038774
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wynn, M
   Freeman, S
AF Wynn, Matthew
   Freeman, Samantha
TI The efficacy of negative pressure wound therapy for diabetic foot
   ulcers: A systematised review
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Review
DE Diabetic foot ulcer; Negative pressure wound therapy; Vac dressing;
   Wound care; Diabetic foot disease
ID CLASSIFICATION-SYSTEM; AREA
AB Aim: This review investigated the current state of knowledge on negative pressure wound therapy (NPWT) used to treat diabetic foot ulceration (DFU), its clinical effectiveness and any current issues in the research. NICE have recommended research into the clinical effectiveness of different dressing types for DFUs since 2015.
   Methods: A systematic search of the British Nursing Index, CINAHL, Cochrane Central and PubMed was undertaken. Only primary studies were included and studies investigating a combination of NPWT and other therapies were excluded. All the included studies were published in English between 2008 and 2018 and were peer reviewed.
   Results: The search yielded seven studies for inclusion in the qualitative analysis. The studies included a variety of methodologies specifically; 3 randomized controlled trials, 2 case series', 1 non-controlled trial and 1 randomized case-control study. Three main themes were identified and formed the focus of the qualitative synthesis.
   Discussion: All the included studies reported that NPWT led to better clinical outcomes when compared to standard treatment. However, the studies had numerous methodological flaws such as the absence of validated tools for the measurement of outcomes such as wound area and depth; a lack of statistical power calculations to determine adequate sample sizes or the significance of outcome measures. Additionally, there was little consistency in the pressures used for the NPWT devices. Finally, many of the controlled trials did not conform to the standard of reporting trials stipulated by the CONSORT statement.
C1 [Wynn, Matthew; Freeman, Samantha] Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England.
C3 University of Manchester
RP Wynn, M (通讯作者)，Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England.
EM matthew.wynn@mft.nhs.uk; Samantha.freeman@manchester.ac.uk
RI ; Freeman, Samantha/AAD-6938-2020
OI Wynn, Matthew/0000-0001-9021-4747; Freeman, Samantha/0000-0002-1290-9145
CR [Anonymous], DIAB PREV MOD
   [Anonymous], NAT DIAB FOOT CAR AU
   [Anonymous], WOUND REPAIR REGEN
   [Anonymous], MANAGEMENT DIABETIC
   [Anonymous], PUSH TOOL
   [Anonymous], NEGATIVE PRESSURE WO
   [Anonymous], APPR EV
   [Anonymous], NEG PRESS WOUND THER
   [Anonymous], WOUND CARE ESSENTIAL
   [Anonymous], 2010, CONSORT STAT
   [Anonymous], PRISMA GROUP PREFERR
   [Anonymous], INT BEST PRACT GUID
   [Anonymous], NEW REG MED DEV
   [Anonymous], J SURG TECH CASE REP
   [Anonymous], DIAB FOOT PROBL PREV
   [Anonymous], STANDARDISING OUTCOM
   [Anonymous], WOUND REPAIR REGEN
   [Anonymous], WOUND REPAIR REGEN
   [Anonymous], DIABET FOOT ANKLE
   [Anonymous], SPIN WOUND CARE RES
   [Anonymous], N06022007 I QUAL WIR
   [Anonymous], EUS SYSTEM REGULATIN
   [Anonymous], NEGATIVE PRESSURE WO
   [Anonymous], J WOUND CARE
   [Anonymous], J CUTAN AESTHET SURG
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NR 58
TC 46
Z9 55
U1 2
U2 37
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD AUG
PY 2019
VL 28
IS 3
BP 152
EP 160
DI 10.1016/j.jtv.2019.04.001
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA IM1XN
UT WOS:000477785300005
PM 31056407
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ioannidis, O
   Anestiadou, E
   Zapsalis, K
   Siozos, K
   Kerasidou, O
   Symeonidis, S
   Bitsianis, S
   Pramateftakis, MG
   Kotidis, E
   Mantzoros, I
   Angelopoulos, K
   Driagka, B
   Cheva, A
   Angelopoulos, S
AF Ioannidis, Orestis
   Anestiadou, Elissavet
   Zapsalis, Konstantinos
   Siozos, Konstantinos
   Kerasidou, Ourania
   Symeonidis, Savvas
   Bitsianis, Stefanos
   Pramateftakis, Manousos-Georgios
   Kotidis, Efstathios
   Mantzoros, Ioannis
   Angelopoulos, Konstantinos
   Driagka, Barbara
   Cheva, Angeliki
   Angelopoulos, Stamatios
TI Tailored Negative Pressure Wound Therapy with instillation in diabetic,
   hypertensive, and obese patients-when guideline treatment is not enough:
   a case series and a proposal for the ANSWER score
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Surgical site infection; Diabetes; BMI; Obesity; Hypertension;
   Microangiopathy; Instillation; Negative pressure wound therapy; NPWTi-d;
   Postoperative soft-tissue defect
ID PROPYL BETAINE; BLOOD-FLOW; BIOFILMS; POLYHEXANIDE; POLIHEXANIDE;
   PENETRATION; MECHANISM; EFFICACY; GROWTH; DEPTH
AB Background Wound healing is challenging in cases of impaired microcirculation, leading to wound chronicity, decreased quality of life, and increased morbidity. Surgical site infections (SSIs) pose a significant challenge in diabetic, hypertensive, and obese patients due to impaired microcirculation. Negative pressure wound therapy (NPWT) is a widely used adjunct in wound management, but its optimal parameters in this subgroup remain uncertain. Tailored management is essential, taking into consideration tissue perfusion status and the potential benefit of novel strategies for tissue healing. Methods We report a case seires of three obese patients with diabetes mellitus type 2 and arterial hypertension who developed severe SSIs after abdominal surgery, with extended flap mobilization and were managed with tailored NPWT strategies, including lower negative pressures, NPWT with instillation and dwell time (NPWTi-d), reticulated open cell foam dressings with through holes (ROCF-CC), and ultrasonic-assisted wound debridement (UAW). Based on these cases, we propose the ANSWER score (tAilored Negative presSure Wound thErapy in micRoangiopathy) to optimize NPWT pressure settings. Results In Patient 1, NPWT using silver dressings was initiated at a continuous pressure of-125 mmHg, but after extended necrosis developed, the negative pressure was reduced to-50 mmHg. In Patients 2 and 3, a continuous NPWT was set at-50 mmHg, which is the lower value of the available negative pressure range for the system used, resulting in significantly fewer necrotic areas. Dressings were changed every 48-72 h and culture-directed antibiotics were administered to all patients. Our findings suggest that the use of NPWT remains a basic element in promoting acute and chronic wound healing. Innovative techniques such as NPWTi-d, ROCF-CC, and UAW debridement, combined with low negative pressure levels, may achieve optimal results in patients with microangiopathy. Microcirculation plays a crucial role in wound healing, since impaired healing and a low rate of tissue regeneration have been observed in patients with compromised tissue perfusion, such as patients with diabetes, obesity, or arterial hypertension. However, the use of NPWT in patients with microangiopathy and extensive tissue dissection at the default operating pressure of-125 mmHg may lead to further ischemic necrosis. Based on our case series, a clinical score (ANSWER score-tAilored Negative presSure Wound thErapy in micRoangiopathy) is proposed as a useful tool that reflects the ideal level of negative pressure for patients with impaired microcirculation. The ANSWER score assigns risk factors (obesity, arterial hypertension, diabetes) a point each, reducing NPWT pressure accordingly (-25 mmHg per point from-125 mmHg). Conclusions Tailored NPWT settings, based on the ANSWER score, may enhance wound healing outcomes in patients with microangiopathy. Further clinical studies are warranted to validate this approach.
C1 [Ioannidis, Orestis; Anestiadou, Elissavet; Zapsalis, Konstantinos; Siozos, Konstantinos; Kerasidou, Ourania; Symeonidis, Savvas; Bitsianis, Stefanos; Pramateftakis, Manousos-Georgios; Kotidis, Efstathios; Mantzoros, Ioannis; Angelopoulos, Konstantinos; Driagka, Barbara; Angelopoulos, Stamatios] Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Dept Gen Surg 4, Thessaloniki 54124, Greece.
   [Cheva, Angeliki] Aristotle Univ Thessaloniki, Sch Med, Dept Pathol, Thessaloniki 54124, Greece.
C3 George Papanikolaou General Hospital of Thessaloniki; Aristotle
   University of Thessaloniki; Aristotle University of Thessaloniki
RP Ioannidis, O (通讯作者)，Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papanikolaou, Dept Gen Surg 4, Thessaloniki 54124, Greece.
EM telonakos@hotmail.com; elissavetxatz@gmail.com; konstzapsalis@yahoo.gr;
   kwstassiwzos@hotmail.gr; kerasidourania@yahoo.gr;
   simeonidissavvas@yahoo.com; sbitsiani@gmail.com;
   mpramateftakis@hotmail.com; skotidis@gmail.com; imanvol@gmail.com;
   kostaggelo@hotmail.com; valiadrg@gmail.com; antacheva@yahoo.gr;
   saggelopoulos@auth.gr
RI Cheva, Angeliki/HGB-6685-2022; Bitsianis, Stefanos/PLC-1440-2026
OI Bitsianis, Stefanos/0000-0001-8281-1189
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NR 63
TC 2
Z9 3
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUL 31
PY 2025
VL 20
IS 1
AR 66
DI 10.1186/s13017-025-00605-7
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 5PR6T
UT WOS:001541373400001
PM 40739263
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Domkowski, PW
   Smith, ML
   Gonyon, DL
   Drye, C
   Wooten, MK
   Levin, LS
   Wolfe, WG
AF Domkowski, PW
   Smith, ML
   Gonyon, DL
   Drye, C
   Wooten, MK
   Levin, LS
   Wolfe, WG
TI Evaluation of vacuum-assisted closure in the treatment of poststernotomy
   mediastinitis
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID WOUND-INFECTION; RISK-FACTORS; SURGERY
AB Objective: Poststemotomy mediastinitis, although infrequent, is a potentially life-threatening complication of cardiac surgery that continues to have a significant morbidity and mortality despite aggressive therapy. Vacuum-assisted closure uses controlled suction to provide evacuation of wound fluid, decrease bacterial colonization, stimulate granulation tissue, and reduce the need for dressing changes.
   Methods: One hundred two patients from Duke University Hospital, The Durham Veterans Administration Hospital, and referring institutions underwent vacuum-assisted closure treatment. There were 63 men and 39 women, with a mean age of 67. The infection was noticed between postoperative days 8 and 34, at which time the wounds were opened and debrided.
   Results: Ninety-six of the 102 patients received vacuum-assisted therapy while the remaining 6 underwent daily multiple dressing changes without vacuum-assisted therapy. Fifty-three-of the 96 patients required only sternal debridement, followed by wound vacuum therapy and closure by secondary intention, while the remaining 43 had an additional procedure. Of these, 33 patients underwent omental transposition and 10 patients had a pectoralis flap. The length of stay for all patients was 27 +/- 12 days. This was related in part to intravenous antibiotics. Hospital mortality for all patients was 3.7% (4 patients). Two of these patients underwent vascular flap and succumbed to multisystemic organ failure, while the other 2 received only wound vacuum therapy following debridement and succumbed to overwhelming sepsis.
   Conclusion: Vacuum-assisted drainage is an effective therapy for mediastinitis following debribement or before placement of a vascularized tissue flap.
C1 Duke Univ, Med Ctr, Div Cardiovasc & Thorac Surg, Dept Surg, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Div Plast Surg, Durham, NC 27710 USA.
   Durham Vet Hosp, Dept Surg, Durham, NC USA.
C3 Duke University; Duke University
RP Wolfe, WG (通讯作者)，Duke Univ, Med Ctr, Div Cardiovasc & Thorac Surg, Dept Surg, Box 3507, Durham, NC 27710 USA.
CR Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
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NR 13
TC 93
Z9 125
U1 0
U2 3
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD AUG
PY 2003
VL 126
IS 2
BP 386
EP 390
DI 10.1016/S0022-5223(03)00352-0
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 715UZ
UT WOS:000184991800016
PM 12928634
OA Bronze
DA 2026-07-24
ER

PT J
AU Lee, R
   Beder, D
   Street, J
   Boyd, M
   Fisher, C
   Dvorak, M
   Paquette, S
   Kwon, B
AF Lee, Robert
   Beder, Daniel
   Street, John
   Boyd, Michael
   Fisher, Charles
   Dvorak, Marcel
   Paquette, Scott
   Kwon, Brian
TI The use of vacuum-assisted closure in spinal wound infections with or
   without exposed dura
SO EUROPEAN SPINE JOURNAL
LA English
DT Article
DE Vacuum-assisted closure; Spinal infection; Exposed dura
ID THERAPY; MANAGEMENT; FUSION; INSTRUMENTATION; COMPLICATIONS; SCOLIOSIS;
   SURGERY; ADULTS; DEFECT
AB Introduction The treatment of postoperative deep spinal wound infection involves debridement and intravenous antibiotics. Authors have previously reported success in a small series of patients treated with vacuum-assisted closure (VAC) therapy, but its use over exposed dura is controversial and the outcome has not been reported in large series.
   Purpose To review the outcomes following the treatment of postoperative spinal infections with VAC therapy, particularly those with exposed dura.
   Methods This is a review of prospectively collected data in 42 patients, all of whom had deep postoperative spinal infections. 30 of these patients had exposed dura. All patients had an initial debridement followed by application of VAC Whitefoam (with exposed dura) or grey Granufoam (where no dura was exposed). Pressure was set at 50 mmHg with exposed dura or 125 mmHg where no dura was exposed. All patients underwent a minimum 6 week course of antibiotics. We report on the number of visits to theatre required for dressing changes and debridement and the eventual outcomes.
   Results Five patients required a flap reconstruction. Two patients died before definitive final closure due to other complications (pneumonia and stroke). In all the other patients, their wounds healed fully. A mean of 2.3 infection surgeries were required to eradicate infection and achieve wound closure.
   Conclusions This is one of the largest studies which confirms the safety and efficacy of VAC dressings in patients with spinal wound infections, even when the dura is exposed.
C1 [Lee, Robert; Beder, Daniel] Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England.
   [Street, John; Boyd, Michael; Fisher, Charles; Dvorak, Marcel; Paquette, Scott; Kwon, Brian] Vancouver Gen Hosp, Vancouver, BC, Canada.
C3 University of London; University College London; Royal National
   Orthopaedic Hospital NHS Trust; University of British Columbia
RP Lee, R (通讯作者)，Royal Natl Orthopaed Hosp NHS Trust, Stanmore, Middx, England.
EM robertlee1@nhs.net
OI Dvorak, Marcel/0000-0002-9404-8448
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NR 25
TC 25
Z9 28
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD OCT
PY 2018
VL 27
IS 10
BP 2536
EP 2542
DI 10.1007/s00586-018-5612-2
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA GX1VT
UT WOS:000447507500015
PM 29696391
DA 2026-07-24
ER

PT J
AU Dorafshar, AH
   Franczyk, M
   Karian, L
   Teven, C
   Wroblewski, K
   Gottlieb, LJ
   Lohman, RF
AF Dorafshar, Amir H.
   Franczyk, Mieczyslawa
   Karian, Laurel
   Teven, Chad
   Wroblewski, Kristen
   Gottlieb, Lawrence J.
   Lohman, Robert F.
TI A Prospective Randomized Trial Comparing Subatmospheric Wound Therapy
   With a Sealed Gauze Dressing and the Standard Vacuum-Assisted Closure
   Device: A Supplementary Subgroup Analysis of Infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE subatmospheric pressure wound therapy; vacuum-assisted closure; gauze
   dressing with suction; infection
ID TOPICAL TREATMENT; INSTILLATION; SYSTEM; DEFECT; PAIN
AB Introduction. Subatmospheric pressure wound therapy (SAWT) is commonly used to manage infected wounds. However, this practice remains controversial because the safety and efficacy of the technique has not been carefully documented. Methods. The authors assessed the safety and efficacy of a sealed gauze dressing with wall suction applied (GSUC) compared to vacuum assisted-closure (VAC), both soaked with topical antimicrobials. Subjects included 31 hospitalized patients with acutely infected wounds compared with 56 patients with noninfected wounds. Results. There were significant reductions in wound surface area and volume in both infected and noninfected groups; there was no significant difference in the rate of change observed in the GSUC vs the VAC arms of the study. In the infected group, the reduction in wound surface area was 4.4% per day for GSUC and 4.8% per day for VAC. Wound volume was 7.8% per day for GSUC, and 9.7% per day for VAC (P < 0.001 for all). Evidence of wound infection in all patients, regardless of treatment group, resolved by 96 hours of onset of treatment, and there were no complications specifically related to the use of a sealed dressing over infected wounds. Conclusion. Gauze dressing with wall suction and VAC therapy can be used in selected acute, infected wounds and both methods of treatment appear to be similarly effective for reducing wound surface area and volume.
C1 [Dorafshar, Amir H.; Franczyk, Mieczyslawa; Teven, Chad; Gottlieb, Lawrence J.] Univ Chicago, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
   Univ Chicago, Dept Therapy Serv, Chicago, IL 60637 USA.
   [Karian, Laurel] Univ Med & Dent New Jersey, Div Plast Surg, Newark, NJ 07103 USA.
   [Wroblewski, Kristen] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
   [Lohman, Robert F.] Cleveland Clin, Dept Plast Surg, Cleveland, OH 44106 USA.
C3 University of Chicago; University of Chicago; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; University of Chicago; Cleveland Clinic Foundation
RP Lohman, RF (通讯作者)，Cleveland Clin Fdn, Dept Plast, 9500 Euclid Ave,Desk A-60, Cleveland, OH 44195 USA.
EM robert.lohman@case.edu
RI Teven, Chad/HKO-4889-2023; Dorafshar, Amir/AAP-2657-2021
OI Dorafshar, Amir/0000-0001-7045-3601
FU University of Chicago
FX This study was funded by the Dean and Barbara White Fund, The University
   of Chicago. The authors report no affiliation with KCI, manufacturer of
   the pressure wound therapy device tested in this study.
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NR 47
TC 3
Z9 3
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2013
VL 25
IS 5
BP 121
EP 130
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 154CL
UT WOS:000319649000004
PM 25866892
DA 2026-07-24
ER

PT J
AU Labler, L
   Rancan, M
   Mica, L
   Härter, L
   Mihic-Probst, D
   Keel, M
AF Labler, Ludwig
   Rancan, Mario
   Mica, Ladislav
   Haerter, Luc
   Mihic-Probst, Daniela
   Keel, Marius
TI Vacuum-Assisted Closure Therapy Increases Local Interleukin-8 and
   Vascular Endothelial Growth Factor Levels in Traumatic Wounds
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Vacuum-assisted closure; Epigard; Trauma; Wound; Cytokines
ID SMOOTH-MUSCLE CELLS; CARDIAC MYOCYTES; HUMAN SKIN; EXPRESSION; VEGF;
   CHEMOKINES; RECEPTORS; HYPEROXIA; HYPOXIA; INJURY
AB Background: Clinical observations are suggesting accelerated granulation tissue formation in traumatic wounds treated with vacuum-assisted closure (VAC). Aim of this study was to determine the impact of VAC therapy versus alternative Epigard application on local inflammation and neovascularization in traumatic soft tissue wounds.
   Methods: Thirty-two patients with traumatic wounds requiring temporary coverage (VAC n = 16; Epigard n = 16) were included. At each change of dressing, samples of wound fluid and serum were collected (n = 80). The cytokines interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), and fibroblast growth factor-2 were measured by ELISA. Wound biopsies were examined histologically for inflammatory cells and degree of neovascularization present.
   Results: All cytokines were found to be elevated in wound fluids during both VAC and Epigard treatment, whereas serum concentrations were negligible or not detectable. In wound fluids, significantly higher IL-8 (p < (1.001) and VEGF (p < 0.05) levels were detected during VAC therapy. Furthermore, histologic examination revealed increased neovascularization (p < 0.05) illustrated by CD31 and von Willebrand factor immunohistochemistry in wound biopsies of VAC treatment. In addition, there was an accumulation of neutrophils as well as an augmented expression of VEGF (p < 0.005) in VAC wound biopsies.
   Conclusion: This study suggests that VAC therapy of traumatic wounds leads to increased local IL-8 and VEGF concentrations, which may trigger accumulation of neutrophils and angiogenesis and thus, accelerate neovascularization.
C1 [Labler, Ludwig; Rancan, Mario; Mica, Ladislav; Haerter, Luc; Keel, Marius] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Mihic-Probst, Daniela] Univ Zurich Hosp, Dept Surg Pathol, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Keel, M (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM marius.keel@usz.ch
RI Mihic-Probst, Daniela/AAB-6374-2021
OI Mihic-Probst, Daniela/0000-0002-2215-9958
FU Swiss National Foundation (SNF) [3200B0-105987/1]; UBS, Switzerland
FX This work was supported by grant 3200B0-105987/1 from Swiss National
   Foundation (SNF) and UBS, Switzerland.
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NR 40
TC 133
Z9 169
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAR
PY 2009
VL 66
IS 3
BP 749
EP 757
DI 10.1097/TA.0b013e318171971a
PG 9
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 419ZU
UT WOS:000264259000027
PM 19276749
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Balci, MK
   Ciger, E
   Arslanoglu, S
   Islek, A
AF Balci, Mustafa Koray
   Ciger, Ejder
   Arslanoglu, Secil
   Islek, Akif
TI Necrotizing fasciitis of the head and neck: our experience with
   vacuum-assisted closure therapy
SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
LA English
DT Article
DE Necrotising fasciitis; Head and neck necrotising fasciitis;
   Vacuum-assisted closure
ID SOFT-TISSUE INFECTIONS; COMPUTED-TOMOGRAPHY; MANAGEMENT; DIAGNOSIS
AB ObjectivesTo present the outcomes of our case series of head and neck necrotizing fasciitis (HNNF) in which vacuum-assisted closure (VAC) is used in most of the cases in the treatment.MethodsCase series in a tertiary referral center.ResultsEleven patients were treated for HNNF between January 2008 and January 2017. Patients were two females and nine males, the mean age was 57.1. Oral cavity and tracheotomy/tracheostomy sites were the main aetiological foci of the infection. Three patients were treated with aggressive debridements and conventional dressing, whereas eight patients were treated with incision and exploration followed by limited skin excisions and VAC dressing. The mean number of surgical debridements was 2.3. The mean length of hospital stay was 41.8days. Complications were observed in all patients except one. The mortality rate of HNNF in our series was 18%. The cause of death was severe sepsis and multi-organ failure in one case and mediastinitis followed by respiratory distress syndrome in the other case.ConclusionHNNF is still a mortal disease and surgical debridements are crucial. The current study is the only case series in the literature in which VAC treatment was used in consecutive cases of HNNF. VAC treatment can play a major role in the post-operative care of HNNF patients. It reduces the amount of excised skin during debridements and stimulates wound healing. VAC treatment may be included in the treatment protocol of HNNF alongside surgical debridements and medical therapy.
C1 [Balci, Mustafa Koray; Ciger, Ejder; Arslanoglu, Secil; Islek, Akif] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Otorhinolaryngol, Basin Sitesi Mh, TR-35170 Izmir, Turkey.
C3 Izmir Katip Celebi University; Izmir Ataturk Training & Research
   Hospital
RP Balci, MK (通讯作者)，Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Otorhinolaryngol, Basin Sitesi Mh, TR-35170 Izmir, Turkey.
EM m.koray.balci@gmail.com
RI ciğer, ejder/AAN-3136-2021; İŞLEK, AKİF/AAH-2799-2020; Balcı, Mustafa
   Koray/AAL-4967-2021
OI İŞLEK, AKİF/0000-0001-7058-3457; Balcı, Mustafa
   Koray/0000-0002-7008-1964
CR [Anonymous], ANN SURG
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NR 22
TC 17
Z9 22
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0937-4477
EI 1434-4726
J9 EUR ARCH OTO-RHINO-L
JI Eur. Arch. Oto-Rhino-Laryn.
PD OCT
PY 2018
VL 275
IS 10
BP 2555
EP 2562
DI 10.1007/s00405-018-5096-z
PG 8
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA GS5HV
UT WOS:000443690000018
PM 30120554
DA 2026-07-24
ER

PT J
AU Geiger, S
   McCormick, F
   Chou, R
   Wandel, AG
AF Geiger, Scott
   McCormick, Frank
   Chou, Richard
   Wandel, Amy G.
TI War wounds: Lessons learned from Operation Iraqi Freedom
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID INJURIES; RECONSTRUCTION
AB Background: This study reports the experience of the plastic surgery department at Naval Medical Center San Diego in treating wounds resulting from combat during Operation Iraqi Freedom. Introduction of new technology and modification of medical treatments have emerged to provide greater success in preserving life and limb.
   Methods: The authors conducted a retrospective review of all Navy and Marine Corps casualties treated by the authors' department between April of 2003 and December of 2005. All medical information surrounding the patients' treatment and medivac rosters were used to collect the data.
   Results: The authors treated 68 patients, who underwent 240 operations. The age distribution was consistent with military enlistments (19 to 38 years). The majority of injuries were from blast (55 percent) and gunshot wounds (19 percent). The extremities were the site of injury in 9.1.2 percent of patients, with lower extremity wounds outnumbering upper extremity wounds approximately 2:1. The authors' wound management technique incorporated an aggressive surgical and antibiotic protocol, antibiotic-impregnated beads, and wound vacuum-assisted closure. The authors' limb salvage rate was high at 93.6 percent, with three amputations performed for flap failure. The acute osteomyelitis rate was 24.2 percent and the chronic osteomyelitis rate was 1.6 percent.
   Conclusions: The authors' results reflect a higher limb salvage rate than that achieved during previous wars. They feel their success was attributable to the use of wound vacuum-assisted closure, an aggressive surgical approach, and appropriate antibiotic therapy. Wound vacuum-assisted closure is the single intervention that is new among the authors' choices of techniques for treating combat wounds.
C1 [Geiger, Scott; McCormick, Frank; Chou, Richard; Wandel, Amy G.] USN, Med Ctr, Dept Plast Surg, San Diego, CA 92152 USA.
C3 United States Department of Defense; United States Navy
RP Wandel, AG (通讯作者)，3160 Folsom Blvd, Sacramento, CA 95816 USA.
EM ghhartman@comcast.net
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NR 19
TC 68
Z9 85
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2008
VL 122
IS 1
BP 146
EP 153
DI 10.1097/PRS.0b013e3181773d19
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 318PO
UT WOS:000257104300018
PM 18594399
DA 2026-07-24
ER

PT J
AU Labler, L
   Trentz, O
AF Labler, Ludwig
   Trentz, Otmar
TI The use of vacuum assisted closure (VAC™) in soft tissue injuries after
   high energy pelvic trauma
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE open fractures; pelvis; soft tissue defect; wound conditioning;
   vacuum-assisted closure
ID NEGATIVE-PRESSURE; DAMAGE CONTROL; WOUND THERAPY; MANAGEMENT; FRACTURES
AB Background Application of vacuum-assisted closure (VAC (TM)) in soft tissue defects after high-energy pelvic trauma is described as a retrospective study in a level one trauma center.
   Materials and methods Between 2002 and 2004, 13 patients were treated for severe soft tissue injuries in the pelvic region. All musculoskeletal injuries were treated with multiple irrigation and debridement procedures and broad-spectrum antibiotics. VAC (TM) was applied as a temporary coverage for defects and wound conditioning.
   Results The injuries included three patients with traumatic hemipelvectomies. Seven patients had pelvic ring fractures with five Morel-Lavallee lesions and two open pelviperineal trauma. One patient suffered from an open iliac crest fracture and a Morel-Lavallee lesion. Two patients sustained near complete pertrochanteric amputations of the lower limb. The average injury severity score was 34.1 +/- 1.4. The application of VAC (TM) started in average 3.8 +/- 0.4 days after trauma and was used for 15.5 +/- 1.8 days. The dressing changes were performed in average every 3 days. One patient (8%) with a traumatic hemipelvectomy died in the course of treatment due to septic complications.
   Conclusions High-energy trauma causing severe soft tissues injuries requires multiple operative debridements to prevent high morbidity and mortality rates. The application of VAC (TM) as temporary coverage of large tissue defects in pelvic regions supports wound conditioning and facilitates the definitive wound closure.
C1 Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Labler, L (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM ludwig.labler@usz.ch
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NR 42
TC 46
Z9 77
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD SEP
PY 2007
VL 392
IS 5
BP 601
EP 609
DI 10.1007/s00423-006-0090-0
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 201DH
UT WOS:000248811200014
PM 16983575
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Wu, JP
   Jiang, ZH
   Feng, XJ
   Jiang, JN
   Cheng, MH
AF Wu, Jian-Ping
   Jiang, Zhen-Huan
   Feng, Xiao-Jun
   Jiang, Jian-Nong
   Cheng, Mao-Hua
TI Negative Pressure Therapy in the Regeneration of the Sciatic Nerve Using
   Vacuum - Assisted Closure in a Rabbit Model
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Contingent Negative Variation; S100 Proteins; Wound Healing
ID WOUND THERAPY; SCHWANN-CELLS; INJURY; REPAIR
AB Background: The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC).
   Material/Methods: Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0 kPa; Group B: -20 kPa; Group C: -40 kPa. At 12 weeks following surgery, the following factors were studied: motor nerve conduction velocity (MNCV); the number of myelinated nerve fibers; the wet weight of the gastrocnemius muscle. Gastrocnemius muscle and sciatic nerve tissue samples were studied for the expression of S100, and brain-derived neurotrophic factor (BDNF) using Western blot.
   Results: At 12 weeks following VAC treatment, the MNCV, number of myelinated nerve fibers, and wet weight of the gastrocnemius muscle showed significant differences between the groups (p<0.05), in the following order: Group B >Group A >Group C. The sciatic nerve at 12 weeks following VAC in Group B and Group C showed a significant increase in expression of S100 and BDNF when compared with Group A; no significant differences were detected between Group B and Group C results from Western blot at 12 weeks.
   Conclusions: The findings of this study, using negative pressure therapy in VAC in a rabbit model of sciatic nerve damage, have shown that moderate negative pressure was beneficial, but high values did not benefit sciatic nerve repair.
C1 [Wu, Jian-Ping; Jiang, Zhen-Huan; Jiang, Jian-Nong] Jiangsu Unvers, Yixing Hosp, Dept Orthopaed, Yixin, Jiangsu, Peoples R China.
   [Feng, Xiao-Jun] Xishan Peoples Hosp Wuxi, Wuxing, Jiangsu, Peoples R China.
   [Cheng, Mao-Hua] Affiliated Hosp Soochow 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
RP Jiang, JN (通讯作者)，Jiangsu Unvers, Yixing Hosp, Dept Orthopaed, Yixin, Jiangsu, Peoples R China.; Cheng, MH (通讯作者)，Affiliated Hosp Soochow 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China.
EM jiangjiannong@yxph.com; wujianping004@sina.com
RI JIANG, ZHENHUAN/KCD-7096-2024
FU Natural Science Foundation for Youth [81402220]; Wuxi Medical Talents
   grant [ZDRC018]
FX The present study was supported by a grant from the Natural Science
   Foundation for Youth (No. 81402220) and the Wuxi Medical Talents grant
   (No. ZDRC018)
CR [Anonymous], BREAST J
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NR 31
TC 0
Z9 0
U1 0
U2 6
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD FEB 19
PY 2018
VL 24
BP 1027
EP 1033
DI 10.12659/MSM.906696
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FX1OL
UT WOS:000425821500002
PM 29457605
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Brem, MH
   Blanke, M
   Olk, A
   Schmidt, J
   Mueller, O
   Hennig, FF
   Gusinde, J
AF Brem, M. H.
   Blanke, M.
   Olk, A.
   Schmidt, J.
   Mueller, O.
   Hennig, F. F.
   Gusinde, J.
TI The vacuum-assisted closure (VAC) and instillation dressing.: Limb
   salvage after 3° open fracture with massive bone and soft tissue defect
   and superinfection
SO UNFALLCHIRURG
LA German
DT Article
DE vacuum-assisted closure; trauma; fracture; tissue defect; wound healing
ID NEGATIVE-PRESSURE; MANAGEMENT; INJURIES; THERAPY
AB We report the case of a 17-year-old boy who was hit by a high velocity train. The polytraumatized patient suffered a 3 degrees open femur defect fracture with a substantial loss of the lateral femoral muscles and significant disruption of the soft tissue of the lower leg. The enormous wound areas on the thigh and the lower leg were infected by Pseudomonas aeruginosa, Enterobacter cloacae, and Stenotrophomonas maltophilia. The enormous tissue defects and the superinfection did not leave any hope for saving the limb from amputation. After rapid aggressive debridement and pulsatile lavage, we covered the wounds as a last resort with a new technique of vacuum-assisted closure (V.A.C) and instillation (V.A.C. Instill((R))) dressings. In sequences of 1 min we instilled Lavasept, kept it for 20 min on the wound surface, and exhausted the liquid. We repeated this for 6 consecutive days and then changed the dressing. In the follow-up examinations the number of germs was significantly reduced. During follow-up care we used the V.A.C. treatment without instillation and finally we transplanted skin onto the clean wound surface and were able to save the leg of this young patient. We discharged him with a good function of his lower leg. This technique of V.A.C. Instill seems to offer great possibilities in critically infected wound situations.
C1 [Brem, M. H.; Blanke, M.; Olk, A.; Mueller, O.; Hennig, F. F.; Gusinde, J.] Univ Klinikum, Chirurg Klin, Abt Unfallchirurg, D-91054 Erlangen, Germany.
   [Schmidt, J.] Univ Klinikum Erlangen, Anasthesiol Klin, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Brem, MH (通讯作者)，Univ Klinikum, Chirurg Klin, Abt Unfallchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM matthias.brem@chir.imed.uni-erlangen.de
RI /I-3462-2012
CR Dedmond BT, 2007, J ORTHOP TRAUMA, V21, P11, DOI 10.1097/BOT.0b013e31802cbc54
   FLEISCHMANN W, 1993, UNFALLCHIRURG, V96, P488
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   LEHNER B, 2007, THERAPY BETTER WOUND, P44
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   WILLY C, 2005, VAKUUMTHERAPIE
NR 13
TC 20
Z9 22
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD FEB
PY 2008
VL 111
IS 2
BP 122
EP 125
DI 10.1007/s00113-007-1360-1
PG 4
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 263BG
UT WOS:000253192000009
PM 18219474
DA 2026-07-24
ER

PT J
AU Mouës, CM
   van den Bemd, GJCM
   Heule, F
   Hovius, SER
AF Moues, C. M.
   van den Bemd, G. J. C. M.
   Heule, F.
   Hovius, S. E. R.
TI Comparing conventional gauze therapy to vacuum-assisted closure wound
   therapy:: A prospective randomised trial
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Wound-Healing-Society
CY 2003
CL SEATTLE, WA
SP Wound Healing Soc
DE clinical randomised trial; vacuum-assisted closure wound therapy;
   conventional wound therapy; assessment of wound healing
ID NEGATIVE-PRESSURE; CLINICAL-EXPERIENCE; SEALING-TECHNIQUE; SYSTEM;
   INFECTIONS; MANAGEMENT; DRESSINGS; ULCERS
AB Background: Vacuum-assisted closure wound therapy (vacuum therapy) has been used in our department since 1997 as a tool. to bridge the period between debridement and definite surgical closure in full-thickness wounds. We performed a prospective randomised ctinicaL trial to compare the efficacy of vacuum therapy to conventional moist gauze therapy in this stage of wound treatment.
   Methods: Treatment efficacy was assessed by semi-quantitative scoring of the wound conditions (signs of rubor, calor, exudate and fibrinous slough) and by wound surface area measurements. Tissue biopsies were performed to quantify the bacterial. load. Besides this, the duration until 'ready for surgical therapy' and complications encountered during therapy and postoperatively were recorded.
   Results: Fifty-four patients were included (vacuum n = 29, conventional n = 25). With vacuum therapy, healthier wound conditions were observed. Furthermore, a tendency towards a shorter duration of therapy was found, which was most prominent in late-treated wounds. In addition, the wound surface area reduced significantly faster with vacuum therapy. Surprisingly, these results were obtained without a decrease in the number of bacteria colonising the wound. Complications were minor, except for one case of septicaemia and one case of increased tissue necrosis, which compelled us to stop vacuum therapy. For the treatment of full-thickness wounds, vacuum therapy has proven to be a valid wound heating modality. (c) 2006 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, NL-3000 DR Rotterdam, Netherlands.
   Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, PO Box 1738, NL-3000 DR Rotterdam, Netherlands.
EM cmoues@hotmail.com
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   Wu SH, 2000, EUR J PLAST SURG, V23, P174, DOI 10.1007/s002380050243
NR 41
TC 138
Z9 169
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2007
VL 60
IS 6
BP 672
EP 681
DI 10.1016/j.bjps.2006.01.041
PG 10
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 179IC
UT WOS:000247282000017
PM 17485058
DA 2026-07-24
ER

PT J
AU Gustafsson, R
   Sjögren, J
   Malmsjö, M
   Wackenfors, A
   Algotsson, L
   Ingemansson, R
AF Gustafsson, R
   Sjögren, J
   Malmsjö, M
   Wackenfors, A
   Algotsson, L
   Ingemansson, R
TI Vacuum-assisted closure of the sternotomy wound: Respiratory mechanics
   and ventilation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID CARDIAC-SURGERY; STERNAL WOUNDS; MEDIASTINITIS; INFECTIONS; PRESSURE;
   THERAPY; COMPLICATIONS; EXPERIENCE; SYSTEM
AB Background: Numerous authors have reported promising results with the use of vacuum-assisted closure therapy in poststernotomy mediastinitis. The negative pressure applied to the anterior mediastinum substantially exceeds the normal negative pressure in the pleural cavities, and interaction with respiratory physiology cannot be excluded. The aim of the present study was to evaluate whether the application of six clinically relevant negative pressures between -50 mmHg and -175 mmHg to the sternotomy wound affects respiratory parameters in a porcine model.
   Methods: A midline sternotomy was performed in six mechanically ventilated pigs weighing 70 +/- 3 kg. Vacuum-assisted closure therapy was applied with continuous negative pressure in a randomized order to the sternotomy wound. The following respiratory parameters were monitored by a carbon dioxide-based noninvasive monitoring system connected to the ventilator: carbon dioxide elimination, peak inspiratory pressure, peak expiratory flow, alveolar minute volume, alveolar tidal volume, expired tidal volume, static compliance, and airway resistance.
   Results: All pigs survived the treatment, and there was no significant change in the respiratory parameters investigated at any of the six negative pressures applied. A tendency toward increased airway resistance was noted when -175 mmHg was applied, although this change was not significant.
   Conclusions: The application of negative pressure therapy in the treatment of deep poststernotomy infections is a novel modality gaming increased attention. In this Study, no impairment in respiratory mechanics, ventilation, or oxygenation was detected when comparing applied pressures ranging from -50 mmHg to -175 mmHg in the sternotomy wound.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Gustafsson, R (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM ronny.gustafsson@thorax.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; 
CR Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
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   Bitkover CY, 1998, ANN THORAC SURG, V65, P36, DOI 10.1016/S0003-4975(97)01003-5
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Francel TJ, 2001, ANN THORAC SURG, V72, P1411, DOI 10.1016/S0003-4975(00)02008-7
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Harlan JW, 2002, PLAST RECONSTR SURG, V109, P710, DOI 10.1097/00006534-200202000-00045
   Haryadi DG, 2000, J CLIN MONIT COMPUT, V16, P361, DOI 10.1023/A:1011403717822
   Hersh RE, 2001, HEART SURG FORUM, V4, P211
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   POCOCK SJ, 1983, CLIN TRIALS PRACTICA, P110
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   Robicsek F, 2000, AM SURGEON, V66, P184
   Schroeyers P, 2001, EUR J CARDIO-THORAC, V20, P743, DOI 10.1016/S1010-7940(01)00873-9
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
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   Tammelin A, 2002, J CLIN MICROBIOL, V40, P2936, DOI 10.1128/JCM.40.8.2936-2941.2002
   Tang A T, 2000, J Wound Care, V9, P229
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P244, DOI 10.1111/j.1067-1927.2004.012117.x
NR 36
TC 13
Z9 16
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR 1
PY 2006
VL 117
IS 4
BP 1167
EP 1176
DI 10.1097/01.prs.0000200620.77353.40
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 031IK
UT WOS:000236697800015
PM 16582783
DA 2026-07-24
ER

PT J
AU Dzieciuchowicz, L
   Espinosa, G
   Grochowicz, L
AF Dzieciuchowicz, Lukasz
   Espinosa, Gaudencio
   Grochowicz, Lukasz
TI Vacuum assisted closure (VAC) in the treatment of advanced diabetic foot
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Diabetic foot; Vacuum assisted closure; Debridement
ID RANDOMIZED CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; MULTICENTER;
   EXPERIENCE; AMPUTATION
AB Introduction: Deep diabetic foot lesions pose an enormous therapeutic problem. The purpose of this study was to present the experience of the use of vacuum assisted closure (VAC) in the treatment of advanced and complicated diabetic foot lesions.
   Material and methods: Five cases of advanced diabetic foot that were treated with VAC were prospectively studied. Three patients were diagnosed with renal failure, including one with renal transplant, who were receiving immunosuppression therapy. Four patients had undergone local foot surgery. The foot lesions were classified as grade 3 or 4 according to the Wagner classification. In all patients extensive debridement was performed that resulted in open minor amputations in four cases and resection of the metatarsophalangeal joint in one case. The VAC was applied during the same procedure. The median follow-up period of the patients was 9 months.
   Results: Foot salvage was achieved in all cases. The median number of changes of VAC was 16 within median period of 8 weeks. Half of the changes were performed as an outpatient procedure. There were no major complications or clinical signs of infection observed. in one case before treatment with VAC began, angioplasty of the iliac artery and superficial femoral artery was performed. Other interventions carried out after the treatment was started were, two distal revascularizations and two partial transmetatarsal amputations.
   Conclusions: VAC appears to be very useful in the treatment of advanced diabetic foot lesions. (C) 2008 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Dzieciuchowicz, Lukasz; Espinosa, Gaudencio; Grochowicz, Lukasz] Univ Navarra Clin, Pamplona, Spain.
C3 University of Navarra
RP Dzieciuchowicz, L (通讯作者)，Univ Navarra Clin, Pamplona, Spain.
EM ldzieciuchow@unav.es
RI Dzieciuchowicz, Łukasz/GZA-8667-2022
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Clare MP, 2002, FOOT ANKLE INT, V23, P896, DOI 10.1177/107110070202301002
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   US Department of Health and Human Services, 1997, DIAB SURV
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NR 13
TC 5
Z9 8
U1 0
U2 7
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0009-739X
J9 CIR ESPAN
JI Cir. Espan.
PD OCT
PY 2009
VL 86
IS 4
BP 213
EP 218
DI 10.1016/j.ciresp.2009.06.003
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 505OV
UT WOS:000270704600004
PM 19683224
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Wiseman, J
   Cullington, JR
   Schaeferle, M
   Beckham, PH
   Salisbury, M
   Ersek, RA
AF Wiseman, J
   Cullington, JR
   Schaeferle, M
   Beckham, PH
   Salisbury, M
   Ersek, RA
TI Aesthetic aspects of neurofibromatosis reconstruction with the
   vacuum-assisted closure system
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE neurofibromatosis; vacuum assisted closure technique; negative pressure
AB Everyone agrees that any reconstructive procedure should carry with it the maximum of aesthetic considerations in order that the reconstructive procedure presents the minimal deformities. Vacuum-assisted closure-(VAC) has allowed surgeons to achieve this goal by creating the most optimal conditions for proper wound healing and thus the best aesthetic results. We present a tragic case whereby a 28-year-old Hispanic male patient with neurofibromatosis was treated for a soccer ball-sized tumor located on his upper left leg. The treatment plan consisted of partial excision with local flap coverage of the wound; however, due to persistent bleeding and tumor growth within the flap, the flap did not survive and we were left with an open wound measuring 20 x 40 cm extending from the patient's upper knee to his iliac crest. Had we attempted an autograft procedure at this time, there would scarcely have been enough donor skin areas to cover the wound. VAC was implemented in an attempt to control the bleeding and to possibly decrease the size of the wound. With the application of this procedure, the previously uncontrollable bleeding (12 units) stopped immediately, and the wound size shrank to 1/2 of its original dimensions. As a result, the area for skin grafting was decreased and was completed with 100% take. The VAC system turned out to be advantageous in achieving the most optimal conditions for our patient's wound to close and heal properly, allowing for enhancement of the aesthetic considerations for the patient.
CR [Anonymous], ANN PLAST SURG
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   NEUROFIBROMATOSIS NI, V6, P1
NR 4
TC 6
Z9 13
U1 0
U2 0
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0364-216X
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD SEP-OCT
PY 2001
VL 25
IS 5
BP 326
EP 331
DI 10.1007/s00266-001-0013-y
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 488RQ
UT WOS:000171949800002
PM 11692244
DA 2026-07-24
ER

PT J
AU Cao, L
   Peng, MM
   Sun, JJ
   Yu, XC
   Shi, B
AF Cao, L.
   Peng, M. M.
   Sun, J. J.
   Yu, X. C.
   Shi, B.
TI Application of vacuum-assisted closure in seawater-immersed wound
   treatment under different negative pressures
SO GENETICS AND MOLECULAR RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; Wound therapy; Seawater immersion; Negative
   pressure
ID SKIN-GRAFTS; THERAPY; DEVICE; EXPRESSION; EXPERIENCE; REPAIR
AB The therapeutic effect of vacuum-assisted closure (VAC) has been confirmed in many types of complex wounds, but there are few relevant reports regarding seawater-immersed wounds. The aim of this study was to determine the effect of VAC on seawater-immersed wound healing under different negative pressures and explore the optimal negative pressure value. Four purebred miniature pigs were used as the experimental animal models. Four acute, symmetrical wounds were made on each side of the spine and designated as the experimental group (wounds with 2 h of seawater immersion) and the control group (wounds without seawater immersion). Wounds were divided into a conventional dressing group and 3 further groups with different VAC therapies (negative pressure at either 120, 180, or 240 mmHg). The extent of wound healing, and speed of granulation growth and re-epithelialization were measured. Bacterial flora distribution in the wounds was observed, and fibronectin levels in the exudate of the wounds were tested. Results showed that seawater immersion aggravated wound injury and that VAC therapy with 180 mmHg negative pressure induced the fastest epidermis migration, obvious edema elimination, significant capillary proliferation, and the highest level of fibronectin, and that in wounds, the proportion of Gram-negative bacteria tended to decrease and that of Gram-positive bacteria tended to increase. Our results show that VAC promotes seawater-immersed wound healing and that 180 mmHg negative pressure may be optimal for wound healing.
RP Shi, B (通讯作者)，Chinese Peoples Liberat Army Gen Staff Hosp, Dept Plast Surg, Beijing, Peoples R China.
EM shibingbeijing@126.com
FU Natural Science Research Foundation of China
FX Research supported by grants from the Natural Science Research
   Foundation of China.
CR Byard RW, 2011, FORENSIC SCI MED PAT, V7, P222, DOI 10.1007/s12024-010-9191-8
   Chan LK, 2009, J WOUND CARE, V18, P14
   Chen XD, 2013, EXP THER MED, V6, P194, DOI 10.3892/etm.2013.1114
   Dahl E, 2011, INT MARIT HEALTH, V62, P186
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   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Gupta S, 2012, INT WOUND J, V9, P40, DOI 10.1111/j.1742-481X.2012.01019.x
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   Labler L, 2006, ZBL CHIR, V131, pS62
   Li HR, 2009, EXTREMOPHILES, V13, P233, DOI 10.1007/s00792-009-0225-7
   Li RG, 2013, MED SCI MONITOR, V19, P510, DOI 10.12659/MSM.883963
   Ma Y, 2009, MICROBIOL RES, V164, P624, DOI 10.1016/j.micres.2008.01.001
   Masden D, 2012, ANN SURG, V255, P1043, DOI 10.1097/SLA.0b013e3182501bae
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2008, WOUND REPAIR REGEN, V16, P488, DOI 10.1111/j.1524-475X.2008.00395.x
   Ogawa R, 2012, Kyobu Geka, V65, P409
   Palm HG, 2011, HNO, V59, P819, DOI 10.1007/s00106-011-2364-2
   Parker P, 2012, J TRAUMA ACUTE CARE, V73, P1630, DOI 10.1097/TA.0b013e3182751bc9
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Witkowski W, 2009, INT WOUND J, V6, P167, DOI 10.1111/j.1742-481X.2009.00586.x
   Wood Benjamin C, 2011, J Surg Orthop Adv, V20, P168
   Yan Hong, 2005, Chin J Traumatol, V8, P147
NR 26
TC 4
Z9 5
U1 0
U2 15
PU FUNPEC-EDITORA
PI RIBEIRAO PRETO
PA RUA FLORIANO PEIXOTO 2444, ALTO DA BOA VISTA, RIBEIRAO PRETO, SP 00000,
   BRAZIL
SN 1676-5680
J9 GENET MOL RES
JI Genet. Mol. Res.
PY 2015
VL 14
IS 2
BP 6146
EP 6155
DI 10.4238/2015.June.8.12
PG 10
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CL7YU
UT WOS:000357189800044
PM 26125815
OA Bronze
DA 2026-07-24
ER

PT J
AU Subotic, U
   Kluwe, W
   Oesch, V
AF Subotic, Ulrike
   Kluwe, Wolfram
   Oesch, Valerie
TI Community-Associated Methicillin-Resistant Staphylococcus
   Aureus-Infected Chronic Scalp Wound With Exposed Dura in a
   10-Year-Old Boy: Vacuum-Assisted Closure Is a Feasible Option: Case
   Report
SO NEUROSURGERY
LA English
DT Article
DE Dura; GranuFoam Silver; MRSA; Pediatric; VAC; Vacuum-assisted closure
ID MANAGEMENT
AB BACKGROUND AND IMPORTANCE: Since the introduction of vacuum-assisted closure (VAC) in 1997, it has been used successfully in treating difficult wounds, including spinal wounds and wounds in pediatric patients. There are no reports on VAC therapy in pediatric patients on the scalp, especially with exposed dura. This report describes a 10-year-old boy with a chronic wound of the scalp with exposed dura after multiple neurosurgical interventions who was treated successfully with VAC.
   CLINICAL PRESENTATION: A 10-year-old mentally disabled boy with Apert syndrome suffered from a chronic wound with community-associated methicillin-resistant Staphylococcus aureus (MRSA) infection after multiple neurosurgeon operations. For wound closure, VAC therapy was initiated on the bony defect with exposed dura. The wound healed successfully, and the MRSA disappeared.
   CONCLUSION: The aims of VAC therapy are formation of new granulation tissue, wound cleansing, and bacterial clearance. In this case, the VAC device was excellent for temporary coverage of the defect and for wound cleaning, and it allowed a thick bed of granulation tissue to form over the dura, even with minimal constant negative pressure. The application and management were feasible even in a mentally disabled child. With this experience, we are encouraged to use the VAC device in difficult wounds, even in the head and neck area in children, and to bring this treatment into the outpatient clinic.
C1 [Subotic, Ulrike] Univ Zurich, Childrens Hosp, CH-8032 Zurich, Switzerland.
   [Kluwe, Wolfram] Asklepios Hosp, St Augustin, Germany.
   [Oesch, Valerie] Univ Bern, Childrens Hosp, Bern, Switzerland.
C3 University of Zurich; University Children's Hospital Zurich; University
   of Bern; University Hospital of Bern
RP Subotic, U (通讯作者)，Univ Zurich, Childrens Hosp, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM subotic18@gmx.net
OI Subotic, Ulrike/0000-0002-1383-1036
CR AMBROSIO A, 2005, VAC GRANUOFOAM SILVE
   Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Donovan DJ, 2006, NEUROSURGERY S2, V58
   Gerry R, 2007, ANN PLAS SURG, V59, P58, DOI 10.1097/01.sap.0000263420.70303.cc
   Khan MAA, 2010, J PLAST RECONSTR AES, V63, P2168, DOI 10.1016/j.bjps.2010.03.017
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   Ploumis A, 2008, J SPINAL DISORD TECH, V21, P320, DOI 10.1097/BSD.0b013e318141f99d
   Siemer S, 2007, EUR UROL, V52, P1156, DOI 10.1016/j.eururo.2007.04.027
   WILLY C, 2005, THEORY PRACTICE VACU, P87
   Zimmerli W, 2003, INFECTION, V31, P99, DOI 10.1007/s15010-002-3079-9
NR 11
TC 16
Z9 22
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-396X
J9 NEUROSURGERY
JI Neurosurgery
PD MAY
PY 2011
VL 68
IS 5
BP E1481
EP E1483
DI 10.1227/NEU.0b013e318210c7fb
PG 3
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 746GE
UT WOS:000289230300006
PM 21307788
DA 2026-07-24
ER

PT J
AU Ma, YQ
   Liang, XP
   Shi, B
   Zhang, C
AF Ma, Yongqi
   Liang, Xianping
   Shi, Bing
   Zhang, Chen
TI Treatment of seawater-immersed blast-injury wounds of pig skin soft
   tissues using vacuum assisted closure technology
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Vacuum assisted closure; seawater immersion; blast injury; tumor
   necrosis factor-alpha; type I collagen; type III collagen
ID EXTRACELLULAR-MATRIX; MODEL
AB The aim of this study was to dynamically observe and compare the effects of vacuum-assisted closure (VAC) technology on the healing of seawater-immersed blast-injury wounds (SIBIW) of pig skin soft tissues, and to summarize the mechanisms of VAC technology in promoting such SIBIW healing, with the goal of providing new experimental evidence for the rescue of such wounds. The bilateral scapular regions and hips of 5 small pigs underwent SIBIW with detonators. After the debridement, the pigs were randomly divided into control and experiment groups (VAC-120 mmHg group, VAC-180 mmHg group, VAC-240 mmHg group), with 5 wounds in each group. The control group's dressings were changed daily, and the experiment group's dressings were changed every other day. All wounds were treated for 9 days, and were observed until they had all healed (i.e., on the 58th day). We then compared and observed the macroscopic and microscopic changes in the wounds of each group. Compared with the control group, the experimental groups showed more active proliferation of peri-wound cells, and faster crawling of the epithelium. In the early stage, the expression of type I collagen was low, while that of type III collagen was higher, the bacterial index decreased rapidly, the bacterial transition was faster, and the wound healed faster. In treating SIBIW, VAC technology had obvious advantages over conventional therapy.
C1 [Ma, Yongqi; Liang, Xianping; Shi, Bing] PLA, Hosp 309, Dept Orthopaed, 17 Heishanhu Rd, Beijing 100091, Peoples R China.
   [Zhang, Chen] Dalian Univ, Affiliated Xinhua Hosp, Dept Orthopaed, Dalian, Peoples R China.
C3 Dalian University
RP Shi, B (通讯作者)，PLA, Hosp 309, Dept Orthopaed, 17 Heishanhu Rd, Beijing 100091, Peoples R China.
EM bingshidoc@163.com
CR Adolph EJ, 2014, J BIOMAT SCI-POLYM E, V25, P1973, DOI 10.1080/09205063.2014.965997
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NR 25
TC 1
Z9 1
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 6
BP 11476
EP 11484
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DQ4ES
UT WOS:000379157300081
DA 2026-07-24
ER

PT J
AU Pascale, R
   Maccaro, A
   Mikus, E
   Baldassarre, M
   Tazza, B
   Esposito, F
   Rinaldi, M
   Tenti, E
   Ambretti, S
   Albertini, A
   Viale, P
   Giannella, M
   Bartoletti, M
AF Pascale, Renato
   Maccaro, Angelo
   Mikus, Elisa
   Baldassarre, Maurizio
   Tazza, Beatrice
   Esposito, Fabio
   Rinaldi, Matteo
   Tenti, Elena
   Ambretti, Simone
   Albertini, Alberto
   Viale, Pierluigi
   Giannella, Maddalena
   Bartoletti, Michele
TI A retrospective multicentre study on dalbavancin effectiveness and
   cost-evaluation in sternotomic wound infection treatment: DALBA SWIT
   Study
SO JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
LA English
DT Article
DE Sternal wound infection; Dalbavancin; Teicoplanin; Daptomycin; Cardiac
   surgery; Cost evaluation
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   SURVIVAL; SURGERY
AB Objective: To evaluate the cost-effectiveness of dalbavancin compared with standard of care (SoC) treatment as daptomycin or teicoplanin in patients with sternal wound infections (SWI). Methods: Multicentre retrospective study of patients diagnosed with SWI from January 2016 to December 2019 at two cardiac surgery facilities treated with dalbavancin, teicoplanin or daptomycin. Patients with SWI treated with dalbavancin were compared with SoC to evaluate resolution of infection at 90 and 180 days from infection diagnosis, length of stay (LoS) and management costs. Results: 48 patients with SWI were enrolled, 25 (50%) male, median age 67 (60-73) years, Charlson index score 5 (4-7). Fifteen patients were treated with dalbavancin (31%) and 33 with SoC (69%): teicoplanin in 21 (63%), and daptomycin in 12 (37%). Staphylococcus species were the most frequent isolates (44, 92%), mostly (84%) resistant to methicillin. All patients were treated with surgical debridement followed by negative pressure wound therapy. Wound healing at day 90 and 180 was achieved in 46 (95.8%) and 34 (82.9%) of patients, respectively. A shorter length of hospitalization in patients treated with dalbavancin compared with SoC [12 (7-18) days vs 22 (12-36) days, p:0.009] was found. Treatment with dalbavancin resulted in total cost savings of euro 16 026 (95% CI 5976-26 076, P < 0.001). Savings were mainly related to the LoS that was significantly shorter in the dalbavancin group, generating significantly lower cost compared to SoC group. Conclusion: Dalbavancin treatment of sternal wound infections is effective and seems to reduce hospitalization length, leading to significantly lower costs.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Pascale, Renato; Maccaro, Angelo; Esposito, Fabio; Rinaldi, Matteo; Viale, Pierluigi; Giannella, Maddalena; Bartoletti, Michele] IRCCS Azienda Osped Univ Bologna, Dept Integrated Management Infect Risk, Infect Dis Unit, Bologna, Italy.
   [Pascale, Renato; Tazza, Beatrice; Viale, Pierluigi; Giannella, Maddalena; Bartoletti, Michele] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Mikus, Elisa; Albertini, Alberto] Maria Cecilia Hosp, GVM Care & Res, Cotignola, Ravenna, Italy.
   [Baldassarre, Maurizio] IRCCS Azienda Osped Univ Bologna, UO Med Semiot, Bologna, Italy.
   [Ambretti, Simone] IRCCS Azienda Osped Univ Bologna, Operat Unit Microbiol, Bologna, Italy.
   [Tazza, Beatrice] Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, IRCCS Policlin St Orsola, Via Massarenti 11, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; Maria Cecilia Hospital; IRCCS Azienda Ospedaliero-Universitaria
   di Bologna; IRCCS Azienda Ospedaliero-Universitaria di Bologna;
   University of Bologna
RP Tazza, B (通讯作者)，Univ Bologna, Dept Med & Surg Sci, Infect Dis Unit, IRCCS Policlin St Orsola, Via Massarenti 11, I-40138 Bologna, Italy.
EM beatrice.tazza@unibo.it
RI Rinaldi, Matteo/AAB-8102-2019; Albertini, Alberto/KQV-4794-2024; Tenti,
   Elena/P-7915-2018; Bartoletti, Michele/K-4621-2018; Baldassarre,
   Maurizio/K-6129-2016; Mikus, Elisa/ABO-4522-2022; Pascale,
   Renato/ABM-9366-2022; GIANNELLA, MADDALENA/K-9090-2016; Ambretti,
   Simone/G-9788-2018
OI Rinaldi, Matteo/0000-0002-3568-5973; Maccaro,
   Angelo/0000-0002-0065-7251; Albertini, Alberto/0000-0001-5374-4298;
   Tenti, Elena/0000-0001-6974-0849; Bartoletti,
   Michele/0000-0002-1099-3283; Baldassarre, Maurizio/0000-0001-7865-394X;
   Mikus, Elisa/0000-0003-2892-8700; Pascale, Renato/0000-0003-2687-4235; 
CR Agarwal R, 2018, CLIN MICROBIOL INFEC, V24, P361, DOI 10.1016/j.cmi.2017.08.028
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NR 26
TC 8
Z9 8
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-7165
EI 2213-7173
J9 J GLOB ANTIMICROB RE
JI J. Glob. Antimicrob. Resist.
PD SEP
PY 2022
VL 30
BP 390
EP 394
DI 10.1016/j.jgar.2022.07.018
EA AUG 2022
PG 5
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 5W4XG
UT WOS:000877918200001
PM 35878780
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Qiu, E
   Kurlander, DE
   Ghaznavi, AM
AF Qiu, Emily
   Kurlander, David E.
   Ghaznavi, Amir M.
TI Godina revisited: a systematic review of traumatic lower extremity wound
   reconstruction timing
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Review
DE Lower extremity reconstruction; free flap; infection
ID SOFT-TISSUE RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; OPEN TIBIAL
   FRACTURES; MICROSURGICAL RECONSTRUCTION; FLAP COVERAGE; IIIB;
   TRANSPLANTATION; MANAGEMENT; DEFECTS; THERAPY
AB Backround: Marko Godina suggested in 1986 that soft tissue coverage of traumatic extremity wounds within 72 h of injury optimizes outcomes. Decades later, these recommendations remain controversial.
   Methods: We performed systematic review of the literature using keywords 'free flap coverage' OR 'soft-tissue reconstruction' AND 'lower extremity trauma' OR 'tibial or fibular fractures'. Patients receiving free flap or local muscle or fascia flaps were included. Patients were divided into two groups, one receiving coverage within 72 h of injury (<72 h) and one after 72 h (>72 h). Primary outcome measures were partial and total flap loss, as well as infection. Use of negative pressure wound therapy (NPWT) was noted. Descriptive statistics were performed.
   Results: Twenty-one publications from 1986 to 2015 were included. The <72 h group had 295 patients and the >72 h group 972 patient. Total flap failure rate was 1.4% if coverage was performed <72 h after injury and 8.8% if >72 h after injury. Partial flap failure rate was 0.4% if coverage was performed <72 h after injury and 1.8% if >72 h after injury. Infection rate was 7.7% if coverage was performed <72 h after injury and 11.6% if >72 h after injury. Among the 182 patients in the >72 h group receiving NPWT, total flap failure rate was 3.6% and total infection rate 7.3%.
   Conclusions: Total and partial flap loss rates, as well as infection rates, were lower when coverage was performed within 72 h of injury. Supporting Godina's recommendation, early soft tissue coverage may be beneficial when circumstances permit. NPWT may be useful when reconstruction is not feasible within 72 h.
C1 [Qiu, Emily; Kurlander, David E.; Ghaznavi, Amir M.] Case Western Reserve Univ, Plast Surg, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Ghaznavi, AM (通讯作者)，11100 Euclid Ave, Cleveland, OH 44116 USA.
EM amirghaznavi@gmail.com
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NR 26
TC 39
Z9 48
U1 0
U2 3
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PY 2018
VL 52
IS 5
BP 259
EP 264
DI 10.1080/2000656X.2018.1470979
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HD8ZX
UT WOS:000452850900001
PM 29966481
OA gold
DA 2026-07-24
ER

PT J
AU Govea-Camacho, LH
   Astudillo-Carrera, A
   Hermosillo-Sandoval, JM
   Rodríguez-Reynoso, S
   González-Ojeda, A
   Fuentes-Orozco, C
AF Humberto Govea-Camacho, Luis
   Astudillo-Carrera, Andrea
   Manuel Hermosillo-Sandoval, Jose
   Rodriguez-Reynoso, Sergio
   Gonzalez-Ojeda, Alejandro
   Fuentes-Orozco, Clotilde
TI Impact of vacuum-assisted closure management in deep neck abscesses
SO CIRUGIA Y CIRUJANOS
LA Spanish
DT Article
DE Deep neck abscesses; Vacuum assisted closure therapy; Wound suture
ID THERAPY; INFECTIONS; MECHANISM; WOUNDS; HEAD
AB Background: The presence of deep neck abscesses is potentially serious; they can lead to death in a short period of time. The vacuum-assisted closure (V.A.C.) therapy has been used in many areas of surgery for complex wound healing. This treatment modality has recently been considered in the field of head and neck surgery.
   Objective: Evaluate the efficacy of healing therapy using V.A.C. therapy in deep neck abscesses.
   Material and methods: Open-label trial. Patients with deep neck abscesses were included using V.A.C. therapy versus conventional therapy. Cultures were taken before and during surgery, and prior to primary wound closure. The percentages of healing, viable tissue, wound healing time, and hospital stay were evaluated.
   Results: A total of 18 patients were included. Affected neck spaces: submaxilar 29%, parapharyngeal 22%, submental 21% and masticatory 13%. The final postsurgical culture was negative in 78%. Viable tissue of the wound for the V.A.C. group was 42%, and for the control group was 36% (p = 0.025). Healing time was 22 +/- 6 days and 38 +/- 15.5, respectively (p = 0.01). The mean number of hospital stay was 12 days for both groups.
   Conclusions: Therapy with V.A.C. is useful in the treatment of deep neck abscesses; it decreased healing time as a result of more viable tissue allowing suture closure of the wound in a shorter period. (C) 2015 Academia Mexicana de Cirugia A.C. Published by Masson Doyma Mexico S.A.
C1 [Humberto Govea-Camacho, Luis; Astudillo-Carrera, Andrea] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Dept Cirugia Cabeza & Cuello, Guadalajara, Jalisco, Mexico.
   [Manuel Hermosillo-Sandoval, Jose] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Dept Cirugia Gen, Guadalajara, Jalisco, Mexico.
   [Rodriguez-Reynoso, Sergio] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Unidad Invest Quirurg Expt, Guadalajara, Jalisco, Mexico.
   [Gonzalez-Ojeda, Alejandro; Fuentes-Orozco, Clotilde] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Occidente, Inst Mexicano Seguro Social, Unidad Med Alta Especialidad,Unidad Invest Med Ep, Guadalajara, Jalisco, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social; Instituto Mexicano del
   Seguro Social
RP Fuentes-Orozco, C (通讯作者)，Calle Nebulosa 2975,Interior 6 C Col, Guadalajara 44520, Jalisco, Mexico.
EM clotildefuen@hotmail.com
RI ; Govea-Camacho, Luis Humberto/AAD-8368-2020
OI GONZALEZ OJEDA, ALEJANDRO/0000-0003-2935-8703; FUENTES OROZCO,
   CLOTILDE/0000-0001-6230-8359; Govea-Camacho, Luis
   Humberto/0000-0002-1141-1898
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NR 27
TC 13
Z9 14
U1 0
U2 4
PU MEXICAN ACAD SURGERY
PI MEXICO D G
PA CENTRO MED NAC SIGLO XXI, EDIFICIO BLOQUE B, SOTANO, AVE CUAUHTEMOC NO
   330, MEXICO D G, 06700, MEXICO
SN 0009-7411
J9 CIR CIR
JI Cir. Cir.
PD JUL-AUG
PY 2016
VL 84
IS 4
BP 275
EP 281
DI 10.1016/j.circir.2015.12.004
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DP9FJ
UT WOS:000378801800003
PM 26908418
OA gold
DA 2026-07-24
ER

PT J
AU Svensson, S
   Monsen, C
   Kölbel, T
   Acosta, S
AF Svensson, S.
   Monsen, C.
   Kolbel, T.
   Acosta, S.
TI Predictors for outcome after vacuum assisted closure therapy of
   peri-vascular surgical site infections in the groin
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE vacuum assisted closure; surgical site infection; synthetic vascular
   graft; groin
ID RANDOMIZED CONTROLLED-TRIAL; MUSCLE FLAP COVERAGE; GRAFT INFECTIONS;
   SYNTHETIC GRAFTS; PRESERVATION
AB Objectives: To assess outcomes (wound heating, amputation and mortality) after vacuum assisted closure (VAC (R)) therapy of peri-vascutar surgical site infections in the groin after arterial surgery.
   Design: Retrospective study.
   Materials: Thirty-three groins received VAC (R) therapy between August 2004 and December 2006 at Vascular Centre, Malmo University Hospital.
   Methods: Following surgical revision, VACO therapy was applied in the groin at a continuous topical negative pressure of 125 mm Hg. The median follow up time was 16 months.
   Results: Median age was 75 years. Twenty-three (70%) cases underwent surgery for lower limb ischaemia. Intestinal flora was present in 88% of the wound cultures. Median duration of VACO therapy was 20 days and 27 (82%) wounds heated within 55 days. One serious VAC (R) associated bleeding and three late false femoral artery aneurysms were reported. The median cost of VACO treatment was 2.7% of the in-hospital costs. Synthetic vascular graft infection (n = 21) was associated with adverse infection-retated events (n = 9; p = 0.012). Non-heating wounds were associated with amputation (p = 0.005) and death (p < 0.001).
   Conclusions: VAC (R) treated synthetic vascular graft infections in the groin were at a greater risk of developing infection-related complications. Non-heating surgical site infections after VAC (R) therapy were associated with amputation and death. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Svensson, S.; Monsen, C.; Kolbel, T.; Acosta, S.] Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
C3 Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Malmo Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Kölbel, Tilo/0000-0002-9962-0204;
   Acosta, Stefan/0000-0002-8895-6001
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NR 21
TC 68
Z9 70
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD JUL
PY 2008
VL 36
IS 1
BP 84
EP 89
DI 10.1016/j.ejvs.2007.12.020
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 329GZ
UT WOS:000257856300016
PM 18294875
OA Bronze
DA 2026-07-24
ER

PT J
AU Bieler, D
   Franke, A
   Völlmecke, M
   Hentsch, S
   Markewitz, A
   Kollig, E
AF Bieler, D.
   Franke, A.
   Voellmecke, M.
   Hentsch, S.
   Markewitz, A.
   Kollig, E.
TI Treatment regimen for deep sternal wound infections after cardiac
   surgical interventions in an interdisciplinary approach
SO UNFALLCHIRURGIE
LA German
DT Article
DE Sternotomy; Interdisciplinary approach; Osteosynthesis; Outcome;
   Comorbidities
ID VACUUM-ASSISTED CLOSURE; PLATELET-RICH PLASMA; RATIONAL APPROACH;
   GLYCEMIC CONTROL; RISK-FACTORS; MUSCLE FLAP; RECONSTRUCTION;
   MEDIASTINITIS; STERNOTOMY; THERAPY
AB The aim of this article is to present the importance of a structured and situation-adapted approach based on the diagnostic and therapeutic strategy in the interdisciplinary treatment of 54 patients with deep sternal wound infections (DSWI) after cardiac surgical interventions and the results achieved. The patients were 41 men and 13 women with an average age of 65.1 years, who developed a DSWI after a cardiac surgical intervention during the period 2003-2016. The treatment strategy included a thorough debridement including the removal of indwelling foreign material, the reconstruction with a stable re-osteosynthesis after overcoming the infection and if necessary, situation-related surgical flaps for a defect coverage with a good blood supply and mandatory avoidance of dead spaces. A total of 146 operations were necessary (average 2.7 operations/patient, range 1-7 operations). In 24.1% of the cases a one-stage approach could be carried out. In 41 patients negative pressure wound therapy (NPWT) with programmed sponge changing was used for wound conditioning (mean 5 changes, standard deviation, SD +/- 5.6 changes over 22 days, SD +/- 23.9 days, change interval every 3-4 days in 40.7% of the cases). In 33 patients a bilateral myocutaneous pectoralis major flap was used, in 4 patients a vertical rectus abdominis myocutaneous (VRAM) flap and in 7 patients both were carried out. A total of 43 osteosynthesis procedures were carried out on the sternum with fixed-angle titanium plates. Of the patients 7 died during intensive care unit treatment (total mortality 13%, n=5, 9.3% <= 30 days) or in the later course. Of the patients 47 (87.1%) could be discharged with a cleansed infection. In 2 patients the implant was removed after 2 years due to loosening.
C1 [Bieler, D.; Franke, A.; Voellmecke, M.; Hentsch, S.; Kollig, E.] Bundeswehrzent Krankenhaus Koblenz, Klin Unfallchirurg & Orthopadie Wiederherstellugs, Verbrennungsmed, Rubenacherstr 170, D-56072 Koblenz, Germany.
   [Bieler, D.] Univ Klinikum Dusseldorf, Klin Orthopadie & Unfallchirurg, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf Hospital
RP Bieler, D (通讯作者)，Bundeswehrzent Krankenhaus Koblenz, Klin Unfallchirurg & Orthopadie Wiederherstellugs, Verbrennungsmed, Rubenacherstr 170, D-56072 Koblenz, Germany.
EM danbieler@uni-duesseldorf.de
RI Bieler, Dan/HZL-5995-2023
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 52
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD MAR
PY 2024
VL 127
IS 3
BP 211
EP 220
DI 10.1007/s00113-023-01394-x
EA DEC 2023
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA LL6H3
UT WOS:001186991000007
PM 38085276
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Castro-Núñez, J
AF Castro-Nunez, Jaime
TI Distraction Sugosteogenesis: Its Biologic Bases and Therapeutic
   Principles
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Active negative pressure; decompression; marsupialization;
   odontogenesis; odontogenic cysts
ID VACUUM-ASSISTED CLOSURE; KERATOCYSTIC ODONTOGENIC-TUMORS; RETRACTED
   ARTICLE. SEE; MARROW STROMAL CELLS; TERM-FOLLOW-UP; CYSTIC LESIONS;
   DENTIGEROUS CYSTS; MECHANICAL STRAIN; NEGATIVE-PRESSURE; BONE-RESORPTION
AB Purpose: Recently, the terms sugosteogenesis and distraction sugosteogenesis have been introduced to the scientific literature. While the former describes a biologic phenomenon, the latter refers to the clinical technique which relies on the accelerated normal bone healing process that takes place at the osseous walls surrounding a cystic cavity when active negative pressure is applied. The purpose of this study is to provide the biologic bases and the therapeutic principles of this emerging technique. Employing well-stablished biologic principles, clinical evidence from analogous techniques, emerging experimental data, and circumstantial evidence, this study presents the possible mechanism of action of the evacuator for odontogenic cysts (Evocyst), a closed, vacuumlike drain system intended to treat cystic conditions using negative pressure.
   Methods: A review of the literature was done. Keywords for the Medline search were: marsupialization, decompression, odontogenic cysts, effects of negative pressure on bone, and negative pressure wound therapy. In addition, relevant publications from the reference list of the retrieved studies were considered. The matches were evaluated for relevance and analyzed accordingly. Clinical reports used to illustrate the concept of distraction sugosteogenesis were performed following the Declaration of Helsinki on medical protocol and ethics.
   Results: Currently, the standard of care to manage odontogenic cystic lesions includes marsupialization, enucleation and curettage, decompression, and surgical resection. However, there is a need for an alternative option in which the entity could be treated while promoting bone formation. With large odontogenic cystic conditions treated in a short period of time, distraction sugosteogenesis appears to be a choice.
   Conclusion: The application of negative pressure to osseous cells produces a stretching that creates mechanical cues that trigger signaling pathways, promotes fluid flow, and enhances angiogenesis. All of them, combined, may explain sugosteogenesis. The clinical application of such parameters may explain the good clinical results obtained with the Evocyst.
C1 [Castro-Nunez, Jaime] Inst Univ Colegios Colombia, Bogota, Colombia.
   [Castro-Nunez, Jaime] Univ Kentucky, Dept Maxillofacial Surg, Lexington, KY USA.
C3 University of Kentucky
RP Castro-Núñez, J (通讯作者)，Inst Univ Colegios Colombia, Res Dept, Autopista Norte Km 20 Via Chia, Bogota, Colombia.
EM jacastron@hotmail.com
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NR 113
TC 11
Z9 13
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD NOV
PY 2018
VL 29
IS 8
BP 2088
EP 2095
DI 10.1097/SCS.0000000000004892
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HX9DS
UT WOS:000467707800051
PM 30334913
DA 2026-07-24
ER

PT J
AU Hwang, KT
   Kim, SW
   Sung, IH
   Kim, JT
   Kim, YH
AF Hwang, Kyu Tae
   Kim, Sang Wha
   Sung, Il Hoon
   Kim, Jeong Tae
   Kim, Youn Hwan
TI Is delayed reconstruction using the latissimus dorsi free flap a worthy
   option in the management of open IIIB tibial fractures?
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FASCIOCUTANEOUS FLAPS;
   PERFORATOR FLAP; COVERAGE; TISSUE; EXTREMITIES; MUSCLE; UNION;
   COMPLICATIONS
AB Early reconstruction of severe open fractures, performed within 7 days of the injury, has a better outcome than closure after 7 days. However, the uncertain demarcation of damaged tissue often results in delayed reconstruction. In this article, we report our surgical outcomes of delayed reconstruction using latissimus dorsi free flap with internal fixation. Twenty-three patients with Gustilo type IIIB open tibial fractures Between March 2009 and May 2012 were included in this study. There were 16 cases of distal 1/3 fracture of the tibia, 4 of midshaft fracture, 1 of proximal 1/3 fracture, and 2 of segmental fracture. Serial debridement with application of negative pressure wound therapy (NPWT) was performed before the final operation. All patients underwent internal fixation of the bone and reconstruction of soft tissue defect using latissimus dorsi free flap. The number of serial debridements, excluding those performed during emergency and finial operation, ranged from 1 to 5 (mean 2.69) times. Mean time from injury to final operation was 10.65 (range, 7-22) days. All flaps survived without complications. Three cases (13%) were infected, and three cases required further bone graft surgery to facilitate bone union (13%). Bone union was achieved after a mean 6.3 (range, 3-12) months. Mean follow-up period was 16.34 (range, 12-26) months. During follow-up, all patients were able to ambulate without use of an aid. In cases of severe open fracture, treatment should emphasize soft tissue coverage rather than rushing to achieve definitive fixation in the setting of poor surrounding tissues. When delayed reconstruction is inevitable, radical debridement is performed first, then NPWT is used as bridging therapy, and free flap could be considered for definite soft tissues coverage. (c) 2015 Wiley Periodicals, Inc. Microsurgery 36:453-459, 2016.
C1 [Hwang, Kyu Tae; Sung, Il Hoon] Hanyang Univ, Dept Orthoped Surg, Coll Med, Seoul, South Korea.
   [Kim, Sang Wha] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
   [Kim, Jeong Tae; Kim, Youn Hwan] Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
C3 Hanyang University; Seoul National University (SNU); Seoul National
   University Hospital; Hanyang University
RP Kim, YH (通讯作者)，Hanyang Univ, Sch Med, Dept Plast & Reconstruct Surg, 17 Haengdang Dong, Seoul 133792, South Korea.
EM younhwank@daum.net
RI Hwang, Kyu/R-7249-2016
OI Kim, Sang Wha/0000-0003-0430-3458
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NR 37
TC 16
Z9 23
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD SEP
PY 2016
VL 36
IS 6
BP 453
EP 459
DI 10.1002/micr.22428
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DW4FT
UT WOS:000383598700002
PM 25976771
DA 2026-07-24
ER

PT J
AU Torbrand, C
   Ugander, M
   Engblom, H
   Arheden, H
   Ingemansson, R
   Malmsjö, M
AF Torbrand, Christian
   Ugander, Martin
   Engblom, Henrik
   Arheden, Hakan
   Ingemansson, Richard
   Malmsjo, Malin
TI Wound contraction and macro-deformation during negative pressure therapy
   of sternotomy wounds
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART PROCEDURES; POSTSTERNOTOMY
   MEDIASTINITIS; AGGRESSIVE MANAGEMENT; EARLY INTERVENTION;
   CARDIAC-SURGERY; BLOOD-FLOW; FOUNDATION; EXPERIENCE; INFECTION
AB Background: Negative pressure wound therapy (NPWT) is believed to initiate granulation tissue formation via macro-deformation of the wound edge. However, only few studies have been performed to evaluate this hypothesis. The present study was performed to investigate the effects of NPWT on wound contraction and wound edge tissue deformation.
   Methods: Six pigs underwent median sternotomy followed by magnetic resonance imaging in the transverse plane through the thorax and sternotomy wound during NPWT at 0, -75, -125 and -175 mmHg. The lateral width of the wound and anterior-posterior thickness of the wound edge was measured in the images.
   Results: The sternotomy wound decreased in size following NPWT. The lateral width of the wound, at the level of the sternum bone, decreased from 39 +/- 7 mm to 30 +/- 6 mm at -125 mmHg (p = 0.0027). The greatest decrease in wound width occurred when switching from 0 to -75 mmHg. The level of negative pressure did not affect wound contraction (sternum bone: 32 +/- 6 mm at -75 mmHg and 29 +/- 6 mm at -175 mmHg, p = 0.0897). The decrease in lateral wound width during NPWT was greater in subcutaneous tissue (14 +/- 2 mm) than in sternum bone (9 +/- 2 mm), resulting in a ratio of 1.7 +/- 0.3 (p = 0.0423), suggesting macro-deformation of the tissue. The anterior-posterior thicknesses of the soft tissue, at 0.5 and 2.5 cm laterally from the wound edge, were not affected by negative pressure.
   Conclusions: NPWT contracts the wound and causes macro-deformation of the wound edge tissue. This shearing force in the tissue and at the wound-foam interface may be one of the mechanisms by which negative pressure delivery promotes granulation tissue formation and wound healing.
C1 [Torbrand, Christian; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Torbrand, Christian; Ugander, Martin; Engblom, Henrik; Arheden, Hakan; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Ugander, Martin; Engblom, Henrik; Arheden, Hakan] Lund Univ, Dept Clin Psychol, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Ugander, Martin/AAQ-4447-2021; Torbrand, Christian/HIZ-8092-2022
OI Ugander, Martin/0000-0003-3665-2038; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599; Torbrand,
   Christian/0000-0001-6442-7554
FU Swedish Medical Research Council; Swedish Government; Lund University
   Hospital; Swedish Medical Association; Royal Physiographic Society in
   Lund; Ake Wiberg Foundation; Anders Otto Sward Foundation/Ulrika Eklund
   Foundation; Magnus Bergvall Foundation; Crafoord Foundation; Anna-Lisa
   and Sven-Erik Nilsson Foundation; Jeansson Foundation; Swedish
   Heart-Lung Foundation; Anna and Edvin Berger's Foundation; Marta
   Lundqvist Foundation; Lars Hierta Memorial Foundation; Lund University
   Faculty of Medicine
FX We thank Einar Heiberg, PhD, for valuable help and advice regarding
   image analysis. This study was supported by the Swedish Medical Research
   Council, Lund University Faculty of Medicine, the Swedish Government
   Grant for Clinical Research, Lund University Hospital Research Grants,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Ake Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika
   Eklund Foundation, the Magnus Bergvall Foundation, the Crafoord
   Foundation, the Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson
   Foundation, the Swedish Heart-Lung Foundation, Anna and Edvin Berger's
   Foundation, the Marta Lundqvist Foundation, and the Lars Hierta Memorial
   Foundation.
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NR 30
TC 22
Z9 23
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD SEP 30
PY 2010
VL 5
AR 75
DI 10.1186/1749-8090-5-75
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 668TD
UT WOS:000283292200001
PM 20920290
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Naude, L
   Balenda, G
   Lombaard, A
AF Naude, L.
   Balenda, G.
   Lombaard, A.
TI Autologous whole blood clot and negative-pressure wound therapy in South
   Africa: A comparison of the cost and social considerations
SO SAMJ SOUTH AFRICAN MEDICAL JOURNAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MANAGEMENT; CARE;
   MULTICENTER; EFFICACY; HEALTH; SKIN
AB Background. Advanced wound treatment modalities enhance healing of hard-to-heal wounds, decrease the risk of amputations, and improve the quality of life of patients. Modalities have different rates of efficacy and incur different social and financial costs to the individual and the healthcare system. Two such modalities, the autologous whole blood clot (WBC) and negative-pressure wound therapy (NPWT), were compared in the South African (SA) context. The comparison was conducted on hard-to-heal wounds, with a specific focus on diabetic foot ulcers (DFUs).Objectives. To compare the social considerations and financial costs of using autologous WBC v. NPWT in the treatment of DFUs in SA. Methods. Data were obtained based on current supply costs from SA suppliers for the two modalities, the standard of care for both modalities, the number of applications required for each, and social considerations provided by SA wound management clinicians. Wound healing rates were obtained from the published literature. This information was used to calculate costs of two scenarios (scenario 1: low exudate v. scenario 2: high exudate), which were compared over two treatment durations (4 and 12 weeks) for each treatment modality. Calculations included weekly cost of supplies, total cost saved by a patient with a DFU managed with either of the wound therapies, and the difference in total cost saved between the two modalities. Key social considerations were assessed qualitatively from discussions with SA clinicians experienced in both autologous WBC and NPWT, and from published research.Results. The cost of supplies per week was ZAR3 250 for autologous WBC and ZAR4 804 for NPWT in scenario 1, and ZAR3 332 and ZAR6 612 in scenario 2. With healing rates over 4 weeks' treatment duration of 19% for autologous WBC and 10% for NPWT, autologous WBC saved ZAR17 719.93, or 9% more than using NPWT, in scenario 1 and ZAR18 381.47, or 10% more, in scenario 2. At 12 weeks' treatment duration, healing rates for autologous WBC and NPWT were 75% and 43%, respectively. In scenario 1, results indicated a 43% cost difference between the two modalities. Autologous WBC had a total cost saving of ZAR61 874.40 compared with NPWT over a period of 12 weeks. In scenario 2, results indicated a 46% cost difference between the two modalities. Autologous WBC had a total cost saving of ZAR70 454.68 compared with NPWT over a period of 12 weeks. One of the identified social considerations is that NPWT needs a reliable supply of electricity to recharge the pump, while autologous WBC does not. Conclusion. Both modalities are safe and effective in treating hard-to-heal wounds of the lower extremities. Autologous WBC consistently demonstrated better outcomes than NPWT in terms of both healing rate and cost-effectiveness, as well as having some advantages in terms of social considerations in SA.
C1 [Naude, L.] Eloquent Learning Hlth & Fdn Profess Dev, Adv Wound Care, Pretoria, South Africa.
   [Naude, L.] Eloquent Learning Hlth & Fdn Profess Dev, Wound Care, Pretoria, South Africa.
   [Balenda, G.] Tembisa Prov Tertiary Hosp, Johannesburg, South Africa.
   [Lombaard, A.] Eloquent Hlth & Wellness, Pretoria, South Africa.
RP Naude, L (通讯作者)，Eloquent Learning Hlth & Fdn Profess Dev, Adv Wound Care, Pretoria, South Africa.; Naude, L (通讯作者)，Eloquent Learning Hlth & Fdn Profess Dev, Wound Care, Pretoria, South Africa.
EM liezl@eloquent.co.za
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   Zhao RL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122085
NR 49
TC 2
Z9 3
U1 0
U2 2
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0256-9574
EI 2078-5135
J9 SAMJ S AFR MED J
JI SAMJ S. Afr. Med. J.
PD OCT
PY 2022
VL 112
IS 10
BP 800
EP 805
DI 10.7196/SAMJ.2022.v112i10.16527
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5M5EM
UT WOS:000871118200007
PM 36472331
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Alreshaid, F
   Aljehani, Y
AF Alreshaid, Farouk
   Aljehani, Yasser
TI Modified application of vacuum-assisted closure in thoracic surgery
   patients
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE intrapleural; negative pressure; pleural; SSI; surgical site infection;
   thoracic surgery; vacuum-assisted closure; VAC therapy; wound; wound
   care; wound dressing; wound healing
ID MANAGEMENT; THERAPY; EMPYEMA
AB Objective: Surgical site infection (SSI), ranging from superficial, deep and to organ space, is one of the major predictors for morbidity and mortality in patients undergoing thoracic surgery. Care to accelerate SSI healing is taken to shorten hospital stay and reduce costs. The deep application of vacuum-assisted closure (VAC) in thoracic patients is not well established in the literature. In this study, the deep application and safety of VAC therapy in patients with various thoracic pathologies was evaluated.
   Method: A retrospective chart review of all patients who were admitted to the thoracic surgery service between July 2014 and July 2018 and who developed deep SSI was carried out.
   Results: A total of 12 patients were included, and their demographic data analysed. There were various thoracic pathologies complicated with postoperative deep SSI treated with VAC. The duration of VAC application ranged from 4-40 days with an average hospital stay of 37.6 days. All patients showed clinical, radiological and microbiological improvement rather than developing complications except for one case of mortality due to septicaemia.
   Conclusion: In this study, partial intrapleural VAC therapy was safe for use in patients who underwent thoracic surgery, regardless of the underling pathology, with caution (i.e., with continued monitoring of the patient's tolerance to the treatment). The overall hospital stay may be reduced with the use of VAC. It also decreased perioperative morbidity, secondary to wound infection.
C1 [Alreshaid, Farouk; Aljehani, Yasser] Imam Abdulrahman Bin Faisal Univ, Dept Surg, Coll Med, Thorac Surg Div,King Fahad Hosp Univ, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Alreshaid, F (通讯作者)，Imam Abdulrahman Bin Faisal Univ, Dept Surg, Coll Med, Thorac Surg Div,King Fahad Hosp Univ, Dammam, Saudi Arabia.
EM freshaid@iau.edu.sa
CR Aljehani Y, 2016, CASE REP SURG, V2016, DOI 10.1155/2016/6805736
   Altintas B, 2015, INT WOUND J, V12, P662, DOI 10.1111/iwj.12198
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   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 13
TC 1
Z9 1
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
SU 4
BP S5
EP S9
DI 10.12968/jowc.2022.31.Sup4.S5
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6OQ
UT WOS:000781592400002
PM 35404712
DA 2026-07-24
ER

PT J
AU Wang, JM
   Xing, H
   Chang, ZQ
AF Wang, Jingming
   Xing, Hao
   Chang, Zhengqi
TI Effects of different sponge implantation methods of negative pressure
   wound therapy on wound healing of deep surgical site infection after
   spinal surgery
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; POSTOPERATIVE INFECTIONS;
   MANAGEMENT; PATIENT
AB PurposeAfter spinal surgery, negative pressure wound treatment (NPWT) improves deep surgical site infection (DSSI) wound healing. This research compared the healing benefits of two sponge implantation strategies in NPWT for DSSI.Methods21 patients with DSSI utilized NPWT to improve wound healing following spine surgery were followed from January 1, 2012 to December 31, 2021. After antibiotic treatment failure, all these patients with DSSI received extensive debridement and NPWT. They are grouped by sponge placement method: centripetal reduction and segment reduction. The two groups' hospital stays, NPWT replacement frequency, wound healing time, healing speed, and quality of wound healing (POSAS score) were compared.ResultsAll patients had been cured by the end of December 2022, and the mean follow-up time was 57.48 +/- 29.6 months. Surgical incision length did not vary across groups (15.75 +/- 7.61 vs. 15.46 +/- 7.38 cm, P = 0.747). The segmental reduction approach had shorter hospital stay and NPWT treatment times than the centripetal reduction method (39.25 +/- 16.04 vs. 77.38 +/- 37.24 days, P = 0.027). Although there is no statistically significant difference, the mean wound healing duration of segmental reduction group is faster than that of centripetal reduction group (0.82 +/- 0.39 vs 0.45 +/- 0.28 cm/d, P = 0.238), wound healing quality (POSAS) (33.54 +/- 8.63 vs 48.13 +/- 12.17, P = 0.408) is better in segmental reduction group, and NPWT replacement frequency (2.62 +/- 1.04 vs 3.88 +/- 1.25, P < .915) is smaller in segmental reduction group.ConclusionsNPWT heals wounds and controls infection. Segmental reduction method accelerates wound healing, reduces hospital stay, and improves wound quality compared to central reduction method.
C1 [Wang, Jingming; Xing, Hao; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com
RI ; hao, xing/ACN-7926-2022
OI Wang, Jing-ming/0000-0002-4499-2086; 
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NR 26
TC 3
Z9 3
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2023
VL 18
IS 9
AR e0291858
DI 10.1371/journal.pone.0291858
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T5QM7
UT WOS:001078533700039
PM 37768971
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Rashed, AM
   Mendoza, A
   Yeh, DD
AF Rashed, Amier Mohamed
   Mendoza, April
   Yeh, D. Dante
TI Enterocutaneous Fistulas: Current Management
SO NUTRIENTS
LA English
DT Review
DE enterocutaneous fistula; enteroatmospheric fistula; fistula; short bowel
   syndrome; intestinal failure; total parenteral nutrition; enteral
   nutrition
ID VACUUM-ASSISTED CLOSURE; UPPER GASTROINTESTINAL FISTULAS; TEMPORARY
   DOUBLE ENTEROSTOMY; LAPAROSCOPIC GASTRIC BYPASS; ENDOSCOPIC SUTURE
   FIXATION; THORACIC ANASTOMOTIC LEAKS; ABDOMINAL-WALL DEFECTS; OCTREOTIDE
   SMS 201-995; COMBINED VICRYL PLUG; SHORT-BOWEL SYNDROME
AB Background: Enterocutaneous fistulas (ECFs) and enteroatmospheric fistulas (EAFs) are rare but highly morbid complications that most commonly arise after abdominal surgery. Outcomes have improved with advances in multidisciplinary care and with increasing research on how to best manage them; however, they remain associated with significant morbidity, high mortality, and prolonged hospitalization. Optimal timing of definitive repair is unknown, with many high-volume centers waiting 6-12 months, though emerging data suggest that earlier intervention may be feasible in carefully selected patients. Given their complexity and variability in management, a comprehensive review of current evidence is needed. Methods: A narrative review of the literature was conducted with emphasis on the classification, pathophysiology, and multidisciplinary management of ECFs and EAFs. Relevant studies addressing fluid and sepsis control, nutritional optimization, wound care, pharmacologic therapies, and interventional strategies were reviewed. Results: The management of ECFs requires a staged approach focused on fluid resuscitation, sepsis control, wound management, and nutritional optimization. Spontaneous closure can occur, and is most commonly within the first two months. Nutritional optimization through enteral and/or parenteral nutrition or fistuloclysis plays a vital role in improving outcomes. Therapies such as negative pressure wound therapy, biologics, and pharmacologic agents may support spontaneous closure and fistula control. In non-healing fistulas, surgical repair remains necessary, with optimal time for surgery at least 6-12 months from fistula development. Conclusions: ECFs and EAFs remain complex surgical challenges. Outcomes have improved due to advances in nutritional support and wound management, and the emergence of minimally invasive techniques. Standardization of treatment protocols and further research into novel therapy may further enhance outcomes and limit variability in management.
C1 [Rashed, Amier Mohamed] Univ Miami, Dept Surg, Miller Sch Med, Miami, FL 33136 USA.
   [Mendoza, April] Univ Calif San Francisco UCSF East Bay, Dept Surg, Oakland, CA 94602 USA.
   [Yeh, D. Dante] Univ Colorado, Denver Hlth Med Ctr, Denver, CO 80204 USA.
C3 University of Miami; University of California System; University of
   California San Francisco; Denver Health Medical Center; University of
   Colorado System; University of Colorado Denver
RP Rashed, AM (通讯作者)，Univ Miami, Dept Surg, Miller Sch Med, Miami, FL 33136 USA.
EM axr3572@miami.edu; apmendoza@alamedahealthsystem.org; dante.yeh@dhha.org
FX This research received no external funding.
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NR 216
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN 14
PY 2026
VL 18
IS 12
AR 1926
DI 10.3390/nu18121926
EA JUN 2026
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KB7XK
UT WOS:001803207400001
PM 42356313
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Willy, C
   Stichling, M
   Müller, M
   Gatzer, R
   Kramer, A
   Back, DA
   Vogt, D
AF Willy, C.
   Stichling, M.
   Mueller, M.
   Gatzer, R.
   Kramer, A.
   Back, D. A.
   Vogt, D.
TI Acute therapeutic measures for limb salvage Part 2. Debridement, lavage
   techniques and anti-infectious strategies
SO UNFALLCHIRURG
LA German
DT Article
DE Therapeutic irrigation; Wound infection; Biofilms; Negative pressure
   wound therapy; Vacuum instillation therapy; Open fractures
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; PRESSURE WOUND
   THERAPY; OPEN TIBIA FRACTURES; PULSE-LAVAGE; IN-VITRO; IRRIGATION;
   BIOFILM; MANAGEMENT; FEMUR
AB The quality of the primary care of Gustilo-Anderson (GA) type IIIB and IIIC extremity injuries is crucial to the success of the limb salvage procedure. This article provides a compilation of consistent, but often controversially discussed aspects of initial debridement, modern techniques of lavage and wound closure, in addition to current issues on the application of antibiotics and antiseptics, based on our own experiences and the latest literature. The following points should be stressed. Severe extremity injuries with gross contamination (GA IIIA, B, and C) will still be associated with an infection rate of up to 60 %. The initial debridement should be performed as soon as an experienced trauma surgeon is available. Tissue that is definitely avital will have to be removed, whereas traumatized but potentially surviving tissue will have to be re-evaluated during a second-look operation after 36-48 h. Given a high enough level of contamination, biofilms will form after as few as 6 h. The perioperative antibiotic prophylaxis has to be initiated early and should be continued for at least 24 h (GA I/II) or up to 5 days (GA III). In cases of bacterial contamination, wound irrigation will be useful with additives such as polyhexanide, octenidine or superoxidized water. Rinsing of the wound should be performed with 3-9 L and only slight manual pressure (no jet lavage). The definitive primary closure of a wound should be achieved in the initial operation, but only in the case of certain "decontamination" and overall vitality of the wound (GA I and II). In the presence of high-grade injuries, a temporary vacuum sealing technique can be used until the earliest possible definitive plastic surgical wound closure.
C1 [Willy, C.; Vogt, D.] Bundeswehrkrankenhaus Berlin, Exzellenz Zentrum Versorgung Verwundeten Kriegs &, Forsch & Behandlungszentrum Rekonstrukt Defektwun, Abt Unfallchirurg & Orthopadie,Septisch Rekonstru, Scharnhorststr 13, D-10115 Berlin, Germany.
   [Stichling, M.] Bundeswehrkrankenhaus Berlin, Sekt Gefass & Thoraxchirurg, Abt Unfallchirurg & Orthopadie, Septisch Rekonstrukt Chirurg, D-10115 Berlin, Germany.
   [Mueller, M.; Gatzer, R.] Bundeswehr Kiel Berlin, Zent Inst Sanitatsdienstes, Lab Grp Med Mikrobiol, Abt 1, Berlin, Germany.
   [Kramer, A.] Univ Med Greifswald, Inst Hyg & Umweltmed, Greifswald, Germany.
   [Back, D. A.] Bundeswehrkrankenhaus Berlin, Abt Allgemein & Viszeralchirurg, D-10115 Berlin, Germany.
C3 Universitat Greifswald; Greifswald Medical School
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Exzellenz Zentrum Versorgung Verwundeten Kriegs &, Forsch & Behandlungszentrum Rekonstrukt Defektwun, Abt Unfallchirurg & Orthopadie,Septisch Rekonstru, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
RI /AAJ-3174-2021
OI Back, David Alexander/0000-0001-7552-7753
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   Wiegand C, 2009, WOUND REPAIR REGEN, V17, P730, DOI 10.1111/j.1524-475X.2009.00536.x
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   Wolcott RD, 2010, J WOUND CARE, V19, P45, DOI 10.12968/jowc.2010.19.2.46966
NR 80
TC 7
Z9 9
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD MAY
PY 2016
VL 119
IS 5
BP 388
EP +
DI 10.1007/s00113-016-0178-0
PG 11
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA DM5SB
UT WOS:000376409200007
PM 27160730
DA 2026-07-24
ER

PT J
AU Pandey, V
   Mishra, SP
   Kaushik, MB
   Khobragade, M
   Gaur, SKS
   Nandan, R
AF Pandey, Vaibhav
   Mishra, Shashi Prakash
   Kaushik, Marripati Bhanumurthy
   Khobragade, Manish
   Gaur, Sunil Kumar Singh
   Nandan, Ruchira
TI Outcomes of vacuum-assisted and conventional wound management in
   pediatric abdominal surgery: A retrospective study from a
   resource-limited setting
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Pediatric wound manager; Pediatric complex wounds; VAC in pediatric
   patients; Traditional wound management vs. newer techniques in pediatric
   patients; Negative pressure wound therapy
ID NEGATIVE-PRESSURE THERAPY; CLOSURE; INFANTS
AB Background: Complicated abdominal wounds following pediatric laparotomy, particularly in cases of enterocutaneous fistulae, trauma, or re-exploration, present significant management challenges, especially in resource-limited settings. Despite evidence supporting vacuum-assisted closure (VAC) therapy in adults, its use in pediatric populations remains limited. Aim: This study aimed to evaluate and compare the outcomes of vacuum-assisted and conventional wound management techniques in pediatric abdominal surgery within a resource-constrained environment. Methods: A retrospective observational study was conducted at a tertiary pediatric surgical centre in Northern India from January 2016 to December 2024. A total of 43 children (0-18 years) with complicated postoperative abdominal wounds were included. Patients were divided into two groups: Group 1 (n = 19) underwent traditional wound closure, while Group 2 (n = 24) received wound management using VAC therapy or simple wound manager systems. Primary outcomes were time to wound healing and incidence of wound-related complications. Secondary outcomes included hospital stay, re-exploration, and spontaneous fistula closure. Results: The wound manager group showed a slightly longer median healing time (15 vs. 12 days) but had zero re-explorations compared to three cases in the traditional group (p = 0.0011). VAC therapy led to earlier granulation (median 6 vs. 10 days), greater complete epithelialization (80 % vs. 40 %, p = 0.04), and spontaneous closure in 20 % of enterocutaneous fistulas. Four patients continued VAC therapy at home without complications. Conclusion: VAC and simple wound manager systems are effective in managing complex pediatric abdominal wounds, reducing the need for reoperation and enhancing healing outcomes. Their adoption in low-resource settings could significantly improve pediatric surgical care. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Pandey, Vaibhav; Kaushik, Marripati Bhanumurthy; Khobragade, Manish; Gaur, Sunil Kumar Singh; Nandan, Ruchira] IMS BHU, Dept Pediat Surg, Varanasi 221005, Uttar Pradesh, India.
   [Mishra, Shashi Prakash] IMS BHU, Dept Gen Surg, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Nandan, R (通讯作者)，Atal Bihari Vajpayee Inst Med Sci & Dr Ram Manohar, Dept Pediat Surg, New Delhi, India.
EM ruchira.nandan@gmail.com
RI Nandan, Ruchira/ADG-3155-2022; /AAR-7896-2020
OI Nandan, Ruchira/0000-0002-1563-7771; Marripati, Bhanumurthy
   Kaushik/0000-0001-8448-7984
CR Adamkova M, 2005, Acta Chir Plast, V47, P24
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   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
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   Yadav S, 2017, PAN AFR MED J, V28, DOI 10.11604/pamj.2017.28.246.9606
NR 23
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD OCT
PY 2025
VL 60
IS 10
AR 162495
DI 10.1016/j.jpedsurg.2025.162495
EA AUG 2025
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 6PF9X
UT WOS:001558746500001
PM 40749973
DA 2026-07-24
ER

PT J
AU Liu, WJ
   Gu, W
   Jin, XF
   Wang, J
AF Liu, Weijiao
   Gu, Wei
   Jin, Xiaofeng
   Wang, Jian
TI Effects of Simultaneous versus Staged VAC Placement in the Treatment of
   Deep Neck Multiple-Space Infections at a Tertiary Hospital Over a
   Four-Year Period in China
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE deep neck multiple-space infections; DNMIs; necrotizing fasciitis;
   surgical treatment; negative pressure wound therapy
ID PRESSURE-WOUND-THERAPY; ASSISTED CLOSURE; MANAGEMENT; ABSCESSES
AB Purpose: Surgical drainage is an essential part of treatment for deep neck infections (DNIs) or deep neck multiple-space infections (DNMIs). With the emergence and application of new technologies and new materials, vacuum-assisted closure (VAC) in the treatment of DNMIs has been reported. However, reports on the timing of VAC placement are limited. Herein, we compared simultaneous versus staged VAC placement in the treatment of DNMIs. Patients and Methods: Medical data from 24 patients with DNMIs who had received VAC treatment in the last five years were analyzed. The patients were classified into a simultaneous VAC placement group (11 patients) and a staged VAC placement group (13 patients) according to the timing of VAC placement when incision and drainage were performed. Results: No differences in baseline characteristics were found between the two groups. All patients in the two groups survived and recovered. The hospitalization duration (days), time to wound healing (days), number of debridement procedures, and disease course (days) in the simultaneous VAC placement group and staged VAC placement group were 10 (4-18) and 22 (8-35), 21 (4-39) and 50 (9-86), one (1-2) and two (1-4), and 31.5 (11-49) and 56 (19-98), respectively. The results in the simultaneous VAC placement group were better than those in the staged VAC placement group (P = 0.001, 0.016, 0.045, and 0.016, respectively). The numbers of VAC sponge changes in the simultaneous VAC placement group and staged VAC placement group were two (1-2) and two (1-4), respectively, with no statistically significant difference (P = 0.336). Conclusion: Simultaneous VAC placement during incision and drainage may shorten the wound healing time, hospitalization duration, and disease course and may reduce the number of debridement procedures.
C1 [Liu, Weijiao; Gu, Wei; Jin, Xiaofeng; Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
   [Liu, Weijiao] Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Pinggu Campus, Beijing, Peoples R China.
   [Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital; Peking
   Union Medical College
RP Wang, J (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otolaryngol Head & Neck Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.
EM wangjianent@126.com
FU Nature Science Foundation of Beijing, China [7192171]
FX This study was funded by the Nature Science Foundation of Beijing, China
   (Grant No. 7192171) .
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NR 29
TC 3
Z9 6
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2021
VL 14
BP 4091
EP 4096
DI 10.2147/IDR.S334203
PG 6
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA WH0EX
UT WOS:000707363400002
PM 34675554
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Seidel, D
   Lefering, R
AF Seidel, Dorthe
   Lefering, Rolf
TI NPWT Resource Use Compared With Conventional Wound Treatment in
   Subcutaneous Abdominal Wounds With Healing Impairment After Surgery
   SAWHI Randomized Clinical Trial Results
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal wound; conventional wound treatment; negative pressure wound
   therapy; resource use; surgical wound; wound healing; wound treatment
ID SURGICAL SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; ECONOMIC BURDEN;
   THERAPY; QUALITY; IMPACT; CARE
AB Objective: To compare resource utilization of NPWT and CWT for SAWHI after surgery Summary of Background Data: NPWT is widely used in the management of complex wounds but high-level evidence of its resource use remains sparse. Methods: The multicenter, multinational, randomized clinical SAWHI study enrolled a total of 539 consecutive, compliant adult patients with SAWHI after surgery without fascial dehiscence between August 2, 2011, and January 31, 2018. Patients were randomly assigned to NPWT and CWT stratified by study site and wound size using a centralized web-based tool. Evaluation of direct resource use comprised inpatient and outpatient time, personnel and material for wound treatment, and associated wound-related procedures. The resource use analysis was primarily based on the per protocol population (NPWT 157; CWT 174). Results: Although treatment length within 42 days was significantly shorter in the NPWT arm {Mean [Standard deviation (SD)] NPWT 22.8 (13.4); CWT 30.6 (13.3); P < 0.001 U-test}, hospitalization time was shorter with CWT [Mean (SD) NPWT 13.9 (11.1); CWT 11.8 (10.8); P = 0.047 U-test]. Significantly more study participants were outpatient with CWT [N=167 (96.0%)] than with NPWT [N = 140 (89.2%) (P = 0.017)]. Time for dressing changes per study participant [Mean (SD) (min) NPWT N = 133, 196 (221.1); CWT N = 152, 278 (208.2); P < .001 U-test] and for wound-related procedures [Mean (SD) (min) NPWT 167 (195); CWT 266 (313); P < 0.001 U-test] was significantly lower with NPWT. Conclusions: NPWT reduces resource use and maybe an efficient treatment alternative to CWT for SAWHI after surgery.
C1 [Seidel, Dorthe; Lefering, Rolf] Witten Herdecke Univ, Inst Forsch Operativen Med IFOM, Cologne, Germany.
RP Seidel, D (通讯作者)，Witten Herdecke Univ, Inst Forsch Operativen Med IFOM, Cologne, Germany.
EM Doerthe.Seidel@uni-wh.de
OI Lefering, Rolf/0000-0002-0141-1747
FU manufacturer Kinetic Concepts Incorporated, an Acelity company part of
   3M Company, San Antonio, TX, USA
FX The SAWHI-study was funded by the manufacturer Kinetic Concepts
   Incorporated, an Acelity company, now part of 3M Company, San Antonio,
   TX, USA, which included the financing of personnel and material
   resources for planning, conduct, analysis, and report of the study. In
   addition, the manufacturer provided the vacuum assisted closure (VAC)
   therapy devices and associated consumable supplies.
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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NR 25
TC 7
Z9 9
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2022
VL 275
IS 2
BP E290
EP E298
DI 10.1097/SLA.0000000000004960
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YE0LP
UT WOS:000740824400021
PM 34117147
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lu, RN
   Wang, H
   Zhang, LJ
   Wu, J
   Liu, J
AF Lu, Ruonan
   Wang, Hui
   Zhang, Lijuan
   Wu, Jian
   Liu, Jun
TI Systemic sclerosis complicated by skin ulcers: A case report and
   literature review
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Systemic sclerosis; skin ulcer; infection; interleukin-6; ozone therapy
ID OZONE; METAANALYSIS
AB This article reports the diagnosis and treatment of a 50-year-old female patient with systemic sclerosis complicated by a nonhealing wound on her left hand. Following comprehensive treatments including debridement, vacuum sealing drainage, ozone therapy, skin grafting, and phalangeal fusion, the wound healed successfully. This article highlights the potentially contradictory role of interleukin-6 inhibitors in the treatment of patients with systemic sclerosis and ulcers as well as emphasizes the application value of ozone therapy in improving tissue hypoxia and promoting healing.
C1 [Lu, Ruonan; Wang, Hui; Wu, Jian; Liu, Jun] Gansu Prov Hosp, Dept Burns, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
   [Zhang, Lijuan] Gansu Prov Hosp, Dept Blood Transfus, Lanzhou, Gansu, Peoples R China.
RP Liu, J (通讯作者)，Gansu Prov Hosp, Dept Burns, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM 13659329321@163.com
FU Lanzhou Science and Technology Bureau [No. 2023-2-99]
FX This work was financially supported by the Lanzhou Science and
   Technology Bureau (No. 2023-2-99) and Clinical Medical Research Center
   for Burns and Wound Repair in Gansu Province (No. 21JR7RA674).
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NR 24
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD NOV
PY 2025
VL 53
IS 11
AR 03000605251391945
DI 10.1177/03000605251391945
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9ML4F
UT WOS:001609854500001
PM 41198585
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mehkri, Y
   Hernandez, J
   Panther, E
   Gendreau, J
   Pafford, R
   Rao, DE
   Fiester, P
   Rahmathulla, G
AF Mehkri, Yusuf
   Hernandez, Jairo
   Panther, Eric
   Gendreau, Julian
   Pafford, Ryan
   Rao, Dinesh
   Fiester, Peter
   Rahmathulla, Gazanfar
TI Incisional Wound Vacuum-Evaluation of Wound Outcomes in Comparison With
   Standard Dressings for Posterior Spinal Fusions in Traumatic Patients
SO OPERATIVE NEUROSURGERY
LA English
DT Article
DE Incisional wound vacuum; Negative pressure wound therapy; Posterior
   spinal fusion; Standard dressing; Surgical site infection
ID SURGICAL SITE INFECTION; ASSISTED CLOSURE; RISK-FACTORS; THERAPY;
   DEHISCENCE; SURGERY
AB BACKGROUND:Postoperative incisional negative pressure wound vacuum-assisted closure (VAC) dressings are being used as a primary dressing to optimize wound healing and help avoid complications of infection and dehiscence. Few studies have investigated whether application of VAC dressings on postoperative posterior spinal wounds can reduce the incidence of surgical site infections.OBJECTIVE:To describe our single-surgeon experience of using primary VAC after posterior spinal fusion (PSF) in a large sample of trauma patients.METHODS:This was an Institutional Review Board-approved retrospective comparative study and included all trauma patients presenting to our level 1 safety-net trauma center who required PSF and were operated on by the senior surgeon between 2016 and 2021. Primary outcomes were complications (surgical site infection, readmission for infection, and wound-related return to operating room [OR]) within 90 days after surgery. chi(2) testing and Student t testing were used to assess differences between treatment groups while bivariate and multivariate regression was performed for outcome assessment.RESULTS:Two hundred sixty-four patients met criteria and were included. One hundred fifty-seven (59%) were treated with standard dressing and 107 (41%) with VAC. Patients treated with VAC were more likely to be older (P = .015), have diabetes (P = .041), have an elevated body mass index (P = .020), and had more levels of fusion (P = .002). Despite this, presence of VAC was independently associated with decreased 90-day infection (hazard ratio = 0.397, P = .023) and decreased 90-day return to OR for wound-related reasons (hazard ratio = 0.099, P = .031).CONCLUSION:Compared with the use of standard dressing, VAC was found to decrease surgical site infection and return to OR risk in trauma patients undergoing PSF.
C1 [Mehkri, Yusuf; Hernandez, Jairo; Panther, Eric; Pafford, Ryan; Rahmathulla, Gazanfar] Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32209 USA.
   [Gendreau, Julian] Johns Hopkins Whiting Sch Engn, Dept Biomed Engn, Baltimore, MD USA.
   [Rao, Dinesh; Fiester, Peter] Univ Florida, Coll Med, Dept Neuroradiol, Jacksonville, FL 32209 USA.
   [Rahmathulla, Gazanfar] Univ Florida, Coll Med Jacksonville, Dept Neurosurg, 580W 8th St,Tower 1 8th Floor, Jacksonville, FL 32209 USA.
C3 State University System of Florida; University of Florida; Johns Hopkins
   University; State University System of Florida; University of Florida;
   State University System of Florida; University of Florida
RP Rahmathulla, G (通讯作者)，Univ Florida, Coll Med Jacksonville, Dept Neurosurg, 580W 8th St,Tower 1 8th Floor, Jacksonville, FL 32209 USA.
EM ymehkri@ufl.edu; hernandezjairo@ufl.edu; ericpanther@ufl.edu;
   jgendre1@jhu.edu; ryan.pafford@jax.ufl.edu; dinesh.rao@jax.ufl.edu;
   peter.fiester@jax.ufl.edu; gazanfar.rahmathulla@jax.ufl.edu
RI Rahmathulla FACS FCNS MBA, Gazanfar/D-1890-2014; Rahmathulla,
   Gazanfar/D-1890-2014
OI Rahmathulla FACS FCNS MBA, Gazanfar/0000-0002-0904-1840; Geneau,
   Julian/0000-0001-8412-0437; 
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NR 28
TC 2
Z9 5
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2332-4252
EI 2332-4260
J9 OPER NEUROSURG
JI Oper. Neurosurg.
PD FEB
PY 2023
VL 24
IS 2
BP 138
EP 144
DI 10.1227/ons.0000000000000477
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 8C5ST
UT WOS:000917668800028
PM 36637298
DA 2026-07-24
ER

PT J
AU Atema, JJ
   Gans, SL
   Boermeester, MA
AF Atema, J. J.
   Gans, S. L.
   Boermeester, M. A.
TI Systematic Review and Meta-analysis of the Open Abdomen and Temporary
   Abdominal Closure Techniques in Non-trauma Patients
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; MEDIATED FASCIAL
   TRACTION; DAMAGE CONTROL SURGERY; OPEN MANAGEMENT; WOUND CLOSURE;
   PLANNED REOPERATIONS; COMPARTMENT SYNDROME; SEVERE PERITONITIS; SEPTIC
   ABDOMEN
AB Several challenging clinical situations in patients with peritonitis can result in an open abdomen (OA) and subsequent temporary abdominal closure (TAC). Indications and treatment choices differ among surgeons. The risk of fistula development and the possibility to achieve delayed fascial closure differ between techniques. The aim of this study was to review the literature on the OA and TAC in peritonitis patients, to analyze indications and to assess delayed fascial closure, enteroatmospheric fistula and mortality rate, overall and per TAC technique.
   Electronic databases were searched for studies describing the OA in patients of whom 50 % or more had peritonitis of a non-traumatic origin.
   The search identified 74 studies describing 78 patient series, comprising 4,358 patients of which 3,461 (79 %) had peritonitis. The overall quality of the included studies was low and the indications for open abdominal management differed considerably. Negative pressure wound therapy (NPWT) was the most frequent described TAC technique (38 of 78 series). The highest weighted fascial closure rate was found in series describing NPWT with continuous mesh or suture mediated fascial traction (6 series, 463 patients: 73.1 %, 95 % confidence interval 63.3-81.0 %) and dynamic retention sutures (5 series, 77 patients: 73.6 %, 51.1-88.1 %). Weighted rates of fistula varied from 5.7 % after NPWT with fascial traction (2.2-14.1 %), 14.6 % (12.1-17.6 %) for NPWT only, and 17.2 % after mesh inlay (17.2-29.5 %).
   Although the best results in terms of achieving delayed fascial closure and risk of enteroatmospheric fistula were shown for NPWT with continuous fascial traction, the overall quality of the available evidence was poor, and uniform recommendations cannot be made.
C1 [Atema, J. J.; Gans, S. L.; Boermeester, M. A.] Univ Amsterdam, Acad Med Ctr, Dept Surg G4 142, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Atema, JJ (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Surg G4 142, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM j.j.atema@amc.uva.nl
OI Boermeester, Marja/0000-0003-3890-8105
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NR 87
TC 181
Z9 216
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2015
VL 39
IS 4
BP 912
EP 925
DI 10.1007/s00268-014-2883-6
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CD6WN
UT WOS:000351231100014
PM 25446477
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Xue, X
   Bian, YL
   Yang, M
   Wei, W
   Meng, LM
   Zhang, QF
   Tao, JG
AF Xue, Xin
   Bian, Yuling
   Yang, Meng
   Wei, Wei
   Meng, Lingmin
   Zhang, Qingfu
   Tao, Jianguang
TI Evaluation of injectable platelet-rich fibrin produced by a simple
   twice-centrifugation method combined with vacuum sealing drainage
   technology in the treatment of chronic refractory wounds
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE injectable platelet-rich fibrin; vacuum sealing drainage; chronic
   refractory wounds; wound inflammation; treatment
AB Objective: To evaluate the effects of injectable platelet-rich fibrin (i-PRF) produced by a simple twice-centrifugation method combined with vacuum sealing drainage on wound inflammation and scar formation in chronic refractory wounds (CRW).Methods: A total of sixty-eight patients with CRW who were admitted to our hospital were enrolled in this study. They were then randomly divided into the study group (n = 34) with being treated using negative pressure sealing and drainage technology, and the control group (n = 34) with being treated using injectable platelet-rich fibrin in conjunction with negative pressure sealing and drainage technology. The following were the primary outcomes: scar conditions at 1 and 3 months after the wound was fully healed, wound healing time, hospitalization time, wound healing rate, incidence of adverse reactions, serum inflammatory indices, and pain levels were assessed 1 day before treatment and 14 days after treatment. The secondary outcomes were determined by comparing the proportion of positive bacterial cultures in the two groups on the day before therapy, as well as on the seventh and fourteenth days after treatment.Results: The wound healing time and hospital stay in the study group were significantly lower than that in the control group (all p < 0.001). The wound healing rate of the study group was significantly higher than that of the control group on the 14th day and 28th day after treatment (all p < 0.001). On the 14th day after treatment, the levels of WBC, CRP, and IL-6 in the study group were lower than those in the control group (all p < 0.001). The positive rate of bacterial culture in the study group was significantly lower than that in the control group on the 7th and 14th day after treatment (all p < 0.05). At 1 month and 3 months after treatment, the VSS score in the study group was lower than that in the control group (all p < 0.001). The total defect rate of the study group was also significantly lower than that of the control group (5.88% vs. 29.41%, p = 0.011).Conclusion: The i-PRF produced by simple twice-centrifugation method combined with VSD could reduce wound inflammation and improve scar formation in patients with CRW.
C1 [Xue, Xin; Yang, Meng; Wei, Wei; Meng, Lingmin; Zhang, Qingfu] Hebei Med Univ, Hosp 1, Dept Burn & Plast Surg, Shijiazhuang, Peoples R China.
   [Bian, Yuling] Hebei Water Conservancy Hosp, Dept Obstet & Gynecol, Shijiazhuang, Peoples R China.
   [Tao, Jianguang] Handan Cent Hosp, Dept Burn & Plast Surg, Handan, Peoples R China.
C3 Hebei Medical University
RP Tao, JG (通讯作者)，Handan Cent Hosp, Dept Burn & Plast Surg, Handan, Peoples R China.
EM 24220038677@qq.com
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NR 31
TC 10
Z9 12
U1 0
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD OCT 28
PY 2022
VL 10
AR 979834
DI 10.3389/fbioe.2022.979834
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6F9MS
UT WOS:000884385200001
PM 36394016
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Martin, C
AF Martin, Cameron
TI An unusual presentation of compartment syndrome
SO JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS
LA English
DT Article
DE compartment syndrome; fasciotomy; negative pressure wound therapy;
   orthopedic trauma; paresthesia; edema
AB Compartment syndrome occurs when excessive pressure in an enclosed space in the body compromises perfusion. Without treatment, this condition can cause tissue ischemia and necrosis. Typically, acute compartment syndrome develops acutely after traumatic injury. The article describes a case of delayed compartment syndrome after a fall.
C1 Eastern Maine Med Ctr, Orthoped Trauma Team, Dept Orthoped, Bangor, ME 04401 USA.
C3 Eastern Maine Medical Center
RP Martin, C (通讯作者)，Eastern Maine Med Ctr, Orthoped Trauma Team, Dept Orthoped, Bangor, ME 04401 USA.
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   Ulmer T, 2002, J ORTHOP TRAUMA, V16, P572, DOI 10.1097/00005131-200209000-00006
   Von Volkmann R., 1881, CENTRABL CHIR, P51
NR 9
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1547-1896
EI 0893-7400
J9 JAAPA-J AM ACAD PHYS
JI JAAPA-J. Am. Acad. Physician Assist.
PD MAY
PY 2015
VL 28
IS 5
BP 36
EP 39
DI 10.1097/01.JAA.0000460920.82885.67
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CM3MA
UT WOS:000357585100012
PM 25909540
DA 2026-07-24
ER

PT J
AU Milcheski, DA
   Clivatti, GM
   Santos, RA Jr
   González, CVS
   Monteiro, AA Jr
   Gemperli, R
AF Milcheski, Dimas A.
   Clivatti, Gustavo M.
   Santos Junior, Rafael A.
   Gonzalez, Carol V. S.
   Monteiro Jr, Araldo A.
   Gemperli, Rolf
TI Effectiveness of negative-pressure wound therapy with instillation
   compared to standard negative-pressure wound therapy and traditional
   gauze layer dressing for the treatment of acute traumatic wounds: A
   randomized controlled trial
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Wounds and injuries; Negative-pressure wound therapy; Dressings; Trauma;
   Lower limb; Plastic surgery
ID OUTCOMES
AB Background: Acute traumatic wounds often require prolonged healing time and hospitalization. Negative-pressure wound therapy with instillation and dwell time (NPWTi-d) has demonstrated effectiveness in accelerating patient healing over traditional NPWT, and its benefits are well established in the treatment of chronic infected wounds. However, randomized studies examining the use of NPWTi-d in acute traumatic wounds are scarce. This study aimed to examine the effectiveness of NPWTi-d compared to traditional gauze layer dressing Methods: This single-center, randomized, pragmatic, controlled clinical trial included 120 adult patients with acute traumatic wounds from traffic accidents randomized to NPWTi-d (n = 39), NPWT (n = 41), and gauze dressing (n = 40). Following surgical debridement of the wound bed, all patients underwent definitive wound closure with delayed primary closure, skin grafting, or surgical flaps. The primary outcomes were wound closure time, number of surgical procedures, and hospital length of stay. The secondary outcomes were primary closure type, amputations, complications, and death. Results: Wound closure time was significantly lower in patients with NPWTi-d compared to patients with NPWT and gauze dressing (6.1 vs. 10 vs. 11.7 days, respectively; p < 0.001). Patients with NPWTi-d had fewer surgical procedures than patients with NPWT and gauze dressing (3.0 vs. 3.5 vs. 6.2, respectively; p < 0.001). No significant differences in length of stay were observed among the groups. Conclusions: In this study, patients with acute traumatic wounds who received NPWTi-d experienced shorter wound closure time and fewer surgical procedures than patients who received NPWT or gauze dressing. Clinical Trial Registration: The current study is registered on the Brazilian Clinical Trials Registry (ReBec) platform under the name Comparison between Traditional Dressing, V.A.C. Dressing and V.A.C. Dressing with Instillation in Complex Wounds, ID n degrees RBR-658g535 at https:// (c) 2024 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Milcheski, Dimas A.; Clivatti, Gustavo M.; Santos Junior, Rafael A.; Monteiro Jr, Araldo A.; Gemperli, Rolf] Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
   [Gonzalez, Carol V. S.] Univ Sao Paulo, Sch Nursing, Grad Program Adult Hlth Nursing, Escola Enfermagem EEUSP, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Escola de
   Enfermagem da Universidade de Sao Paulo (EE-USP)
RP Milcheski, DA (通讯作者)，Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
EM dimas.milcheski@hc.fm.usp.br; clivatti@gmail.com;
   rafaeljunior96@hotmail.com; carolvsgonzalez@gmail.com;
   araldo.junior@hc.fm.usp.br; rolf.gemperli@hc.fm.usp.br
RI SERNA GONZÁLEZ, CAROL VIVIANA/AAW-8858-2021; Milcheski,
   Dimas/OIU-4843-2025; Gemperli, Rolf/C-9116-2012
OI SERNA GONZÁLEZ, CAROL VIVIANA/0000-0002-9850-3030; 
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   through the Faculty of Medicine of the University of Sao Paulo [001];
   The 3M(R) Brazil and Global
FX This study was partially funded by the Coordination for the Improvement
   of Higher Education Personnel (CAPES), Financing Code 001, through the
   Faculty of Medicine of the University of Sao Paulo. Additionally, 3M (R)
   Brazil and Global provided financial support, including the supply of
   dressings used in the NPWT and NPWTi-d groups, Ulta machines, and
   funding for a clinical nurse. The funders had no role in the
   methodological design, data collection, analysis, or interpretation of
   the study results.
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NR 24
TC 6
Z9 7
U1 2
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2025
VL 100
BP 208
EP 218
DI 10.1016/j.bjps.2024.11.005
EA DEC 2024
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA P3C0F
UT WOS:001376719800001
PM 39644780
OA hybrid
DA 2026-07-24
ER

PT J
AU Ottomann, C
   Schönborn, A
   Hartmann, B
AF Ottomann, C
   Schönborn, A
   Hartmann, B
TI Management with VAC® in phlegmonous tissue defects of the
   abdominal wall after abdominoplasty
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE abdominoplasty; phlegmonous; VAC((R))-therapy; wound infection
ID VACUUM-ASSISTED CLOSURE; PRESSURE
AB Infected defects with tissue defects of the abdomial wall after abdomioplasty are a severe complication. Management of these progessive infections involves multiple step surgery. V.A.C.(R)-therapy could be an alternative to open wound treatment.
C1 Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, D-12683 Berlin, Germany.
RP Ottomann, C (通讯作者)，Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, Warener Str 7, D-12683 Berlin, Germany.
EM christian.ottomann@ukb.de
CR Cedidi C, 2002, EUR J MED RES, V7, P399
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NR 9
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S85
EP S88
DI 10.1055/s-2004-822662
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600027
PM 15168297
DA 2026-07-24
ER

PT J
AU Baram, A
AF Baram, Aram
TI Invited commentary on "A systematic review and meta-analysis comparing
   the effectiveness of negativepressure wound therapy to standard therapy
   in the prevention of complications after vascular surgery" Int J Surg.
   2020 Mar 3. pii: S1743-9191(20)30202-8. doi: 10.1016/
   j.ijsu.2020.02.037. [Epub ahead of print]
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Letter
DE Groin incisions; Surgical site infections; Negative pressure wound
   therapy; Clinical efficacy
C1 [Baram, Aram] Univ Sulaimani, Fac Med Sci, Sch Med, Dept Surg, Al Sulaymaniyah 46001, Kurdistan Regio, Iraq.
   [Baram, Aram] Sulaimani Teaching Hosp, Dept Thorac & Cardiovasc Surg, Al Sulaymaniyah 46001, Kurdistan Regio, Iraq.
C3 University of Sulaimani
RP Baram, A (通讯作者)，Univ Sulaimani, Fac Med Sci, Sch Med, Dept Surg, Al Sulaymaniyah 46001, Kurdistan Regio, Iraq.
EM aram.baram@univsuil.edu.iq
RI Baram, Aram/P-1155-2016
CR Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
   Benrashid E, 2020, J VASC SURG, V71, P896, DOI 10.1016/j.jvs.2019.05.066
   Chakfé N, 2020, EUR J VASC ENDOVASC, V59, P339, DOI 10.1016/j.ejvs.2019.10.016
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   Sexton F, 2020, INT J SURG, V76, P94, DOI 10.1016/j.ijsu.2020.02.037
NR 5
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JUN
PY 2020
VL 78
BP 50
EP 51
DI 10.1016/j.ijsu.2020.03.077
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LW6NC
UT WOS:000539259900022
PM 32304893
DA 2026-07-24
ER

PT J
AU Hopkins, B
   Eustache, J
   Ganescu, O
   Cipolla, J
   Kaneva, P
   Fried, GM
   Khwaja, K
   Vassiliou, M
   Fata, P
   Lee, L
   Feldman, LS
AF Hopkins, Brent
   Eustache, Jules
   Ganescu, Olivia
   Cipolla, Josie
   Kaneva, Pepa
   Fried, Gerald M.
   Khwaja, Kosar
   Vassiliou, Melina
   Fata, Paola
   Lee, Lawrence
   Feldman, Liane S.
TI S116: Impact of incisional negative pressure wound therapy on surgical
   site infection after complex incisional hernia repair: a retrospective
   matched cohort study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Incisional hernia; Abdominal wall reconstruction; General surgery; Wound
   complication; Surgical site infection; Negative pressure wound therapy;
   Incisional negative pressure wound therapy
ID ABDOMINAL-WALL RECONSTRUCTION; HIGH-RISK PATIENTS; MANAGEMENT;
   COMPLICATIONS; VALIDATION; LAPAROTOMY; PREVENTION; OUTCOMES; SCORE; COST
AB Introduction Incisional negative pressure wound therapy (iNPWT) may reduce surgical site infections (SSI), which can have devastating consequences after incisional hernia repair. Few comparative studies investigate the effectiveness of this wound management strategy in this population. The objective of this study is to determine the effect of iNPWT on the incidence of SSI after complex incisional hernia repair. Methods All adult patients undergoing open incisional hernia repair at a single center from 2016 to 2019 were reviewed. A commercial iNPWT dressing was used at the discretion of the surgeon. Patients were grouped by type of dressing; iNPWT and standard sterile dressings (SSD). Coarsened exact matching was used to create balanced cohorts for comparison using age, sex, American Society of Anesthesiologists classification, wound classification, and surgical urgency. The primary outcome was the composite incidence of superficial and deep SSI within 30 days. Secondary outcomes included non-infectious surgical site occurrences (SSO), overall complications, length of stay (LOS), emergency department visits, and readmission at 30 days. Results 134 patients underwent complex hernia repair, with 114 patients included after matching (34 iNPWT, 51 SSD). Composite incidence of superficial and deep SSI was 19.3% (11.8% vs. 27.5%,p = 0.107), with significantly lower rates of deep SSI in patients receiving iNPWT (2.9% vs. 17.6%,p = 0.045). After accounting for residual differences between groups, iNPWT was associated with decreased incidence of composite SSI (RR 0.36, 95% CI [0.16, 0.87]). Median LOS was longer in patients with iNPWT (7 vs. 5 days,p = 0.001). There were no differences in SSO, overall complications, readmission, or emergency department visits. Conclusion In patients undergoing incisional hernia repair, the use of iNPWT was associated with a lower incidence of SSI at 30 days. Future studies should focus on cost effectiveness of iNPWT, its impact on long-term hernia recurrences, and the identification of patient selection criteria in this population.
C1 [Hopkins, Brent; Eustache, Jules; Kaneva, Pepa; Fried, Gerald M.; Khwaja, Kosar; Vassiliou, Melina; Fata, Paola; Lee, Lawrence; Feldman, Liane S.] McGill Univ, Hlth Ctr, Steinberg Bernstein Ctr Minimally Invas Surg & In, 1650 Cedar Ave,L9-309, Montreal, PQ H3G 1A4, Canada.
   [Hopkins, Brent; Eustache, Jules; Fried, Gerald M.; Khwaja, Kosar; Vassiliou, Melina; Fata, Paola; Lee, Lawrence; Feldman, Liane S.] McGill Univ, Dept Surg, Hlth Ctr, Montreal, PQ, Canada.
   [Ganescu, Olivia; Cipolla, Josie] McGill Univ, Fac Med, Montreal, PQ, Canada.
C3 McGill University; McGill University; McGill University
RP Lee, L (通讯作者)，McGill Univ, Hlth Ctr, Steinberg Bernstein Ctr Minimally Invas Surg & In, 1650 Cedar Ave,L9-309, Montreal, PQ H3G 1A4, Canada.; Lee, L (通讯作者)，McGill Univ, Dept Surg, Hlth Ctr, Montreal, PQ, Canada.
EM larry.lee@mcgill.ca
RI ; Vassiliou, Melina/HNQ-6575-2023
OI Cipolla, Josie/0009-0009-2365-6567; Fried, Gerald/0000-0001-6434-0555; 
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   World Health Organization, 2018, Global guidelines for the prevention of surgical site infection, V2nd
   Xia CY, 2014, MOL MED REP, V9, P1749, DOI 10.3892/mmr.2014.1997
NR 38
TC 10
Z9 13
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD JUL
PY 2021
VL 35
IS 7
BP 3949
EP 3960
DI 10.1007/s00464-020-07857-1
EA AUG 2020
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SR2RM
UT WOS:000556653600001
PM 32761478
DA 2026-07-24
ER

PT J
AU Cai, LY
   Mei, YF
   Chen, CH
   Wang, JW
   Wang, XY
   Zheng, WH
AF Cai, Leyi
   Mei, Yifan
   Chen, Chunhui
   Wang, Jinwu
   Wang, Xingyu
   Zheng, Wenhao
TI Comparison of vacuum sealing drainage and conventional drainage for
   postoperative drainage in closed calcaneal fracture: A randomized
   controlled trial
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Vacuum sealing drainage; Calcaneal fracture; Wound complication; Wound
   healing; Clinical study
ID PRESSURE WOUND THERAPY; DISPLACED INTRAARTICULAR FRACTURES; ASSISTED
   CLOSURE; INTERNAL-FIXATION; SURGICAL INCISIONS; OPEN REDUCTION;
   COMPLICATIONS; MANAGEMENT; EXPERIENCE; INJURIES
AB Background: The objective of this study was to compare the outcomes of vacuum sealing drainage (VSD) and conventional drainage after surgery in the treatment of closed calcaneal fracture. We hypothesize that VSD is superior to conventional drainage in reducing volume of drainage, time of wound drying, time of skin fold, time of wound healing, VAS at day 3 postoperatively, wound complications and increasing wound healing grade.
   Methods: 120 patients with closed calcaneal fractures from January 2016 to December 2018 were enrolled in our study. They were divided randomly into VSD group (n = 60) and conventional (n = 60). The volume of drainage, duration of drainage, time of wound drying, time of skin fold, time of wound healing and VAS at day 3 postoperatively were recorded. Furthermore, the wound complications of the two groups were also evaluated. Besides, wound healing grade was used to assess the degree of wound healing. The functional outcome American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot scores and visual analog scale (VAS) pain scores was also evaluated.
   Results: A total of 10 patients were lost to follow-up for various reasons, VSD group remained 55 cases while conventional group remained 53 cases. Our results showed that VSD group exhibited significantly more volume of drainage (P< 0.0001), longer duration of drainage (P< 0.00 01), shorter time of wound drying (P = 0.0086), shorter time of skin fold (P = 0.0158), shorter time of wound healing (P = 0.0240) and lower VAS at day 3 postoperatively (P = 0.0019) compared with conventional group. Moreover, VSD group was demonstrated to have significantly lower wound complications (P = 0.025) and higher rate grade A of wound healing (P = 0.031). However, no significant difference was noted in time of fracture union (P = 0.754), VAS (P = 0.407) and AOFAS score (P = 0.512) at final follow-up between the two groups.
   Conclusions: Our hypothesis was confirmed that VSD was superior in terms of some aspects than conventional drainage. Therefore, VSD is a safe and effective postoperative wound drainage method in the treatment of closed calcaneal fracture. However, more and higher evidence needs to be carried to demonstrate the results. (C) 2021 Elsevier Ltd. All rights reserved.
C1 [Cai, Leyi; Chen, Chunhui; Wang, Jinwu; Wang, Xingyu; Zheng, Wenhao] Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
   [Cai, Leyi; Mei, Yifan; Chen, Chunhui; Wang, Jinwu; Wang, Xingyu; Zheng, Wenhao] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
   [Mei, Yifan] Wenzhou Med Univ, Dept Emergency, Affiliated Hosp 2, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Zheng, WH (通讯作者)，Wenzhou Med Univ, Dept Orthopaed Surg, Affiliated Hosp 2, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.; Zheng, WH (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou, Peoples R China.
EM zhengwenhao@wmu.edu.cn
RI Wang, Xingyu/AFZ-5722-2022; Zheng, Wenhao/KBR-3871-2024
FU National Nature Foundation of China [81701928]; Zhejiang Province
   Medical and Health Technology Project [2017KY480]; Wenzhou Science and
   Technology Bureau Foundation [Y20160040]
FX The authors thank all the staffs in the department of orthopedics of our
   hospital. This study was funded by the National Nature Foundation of
   China (no. 81701928), Zhejiang Province Medical and Health Technology
   Project (2017KY480) and Wenzhou Science and Technology Bureau Foundation
   (no. Y20160040).
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NR 38
TC 21
Z9 28
U1 1
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2022
VL 53
IS 2
BP 777
EP 783
DI 10.1016/j.injury.2021.10.018
EA JAN 2022
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA ZA5BK
UT WOS:000756178600023
PM 34756414
DA 2026-07-24
ER

PT J
AU Hill, R
AF Hill, Richard
TI Utilizing Negative Pressure Wound Therapy With Instillation and Dwell
   Time to Achieve Source Control of Complex Polymicrobial Necrotizing
   Aeromonas hydrophila Infection Following a Traumatic Amputation:
   A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell; traumatic
   injury; myonecrosis; Aeromonas hydrophilia; infection
ID RAPID PROGRESSION
AB Introduction. Aquatic propeller injuries can pose significant complications in the care of a patient including gross contamination, delayed onset of ischemia, and exposure to unusual water-associated organisms. This case study highlights a circumstance where source control was achieved in a patient that suffered from a polymicrobial necrotizing Aeromonas hydrophila infection following a traumatic aquatic amputation. Case Report. A 26-year-old female sustained a propeller injury in a lake with brackish water that resulted in multiple significant linear lacerations and avulsions as well as a Gustilo IIIB fracture. Due to the extent of injuries, the limb was deemed unsalvageable. Serial washouts began early in the hospital course, but the patient did not hemodynamically tolerate debridement well. Tissue cultures showed a polymicrobial A hydrophila infection. Achievement of source control was attempted through use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) (instillation of 100 mL of 0.125% Dakin's solution, dwell time of 5 minutes, and 2-hour intervals of NPWTi-d at -125 mm Hg) in conjunction with traditional intravenous antibiotics; when this therapy was initiated, the wound measured 51.0 cm x 38 cm x 4 cm with 6.0 cm undermining along the superior border. Within 2 days of NPWTi-d initiation, lab values normalized, and the patient began to clinically improve. By day 17, the NPWTi-d settings were switched to instillation of 80 mL normal saline with a dwell time of 5 minutes and interval 2 hours of NPWT at -125 mm Hg. At day 25, the wound measured approximately 25.0 cm x 30.0 cm. The NPWTi-d was continued throughout hospitalization until grafting was able to be performed; on hospital day 51, nearly 100% take of split-thickness grafting was noted with no residual tissue loss. At 167 days after the initial injury, the patient took her first steps on the prosthetic limb. Conclusions. Negative pressure wound therapy with instillation and dwell time gives clinicians the option to achieve source control in complex wounds with active, myonecrotic, polymicrobial infections through use of bactericidal solution instillation.
C1 [Hill, Richard] Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
RP Hill, R (通讯作者)，Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
EM Hill.richardb@gmail.com
RI Hill, Richard/C-5419-2019
CR Bhatia N, 2017, CASE REP MED, V2017, DOI 10.1155/2017/4607582
   Dong J, 2017, J WORLD AQUACULT SOC, V48, P531, DOI 10.1111/jwas.12351
   Fernández-Bravo A, 2019, P NATL ACAD SCI USA, V116, P24084, DOI 10.1073/pnas.1914395116
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   Hong CK, 2018, KAOHSIUNG J MED SCI, V34, P307, DOI 10.1016/j.kjms.2017.12.001
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NR 10
TC 0
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 364
EP 368
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500001
PM 33472162
DA 2026-07-24
ER

PT J
AU Chicco, M
   Huang, TCT
   Cheng, HT
AF Chicco, Maria
   Huang, Tony Chieh-Ting
   Cheng, Hsu-Tang
TI Negative-Pressure Wound Therapy in the Prevention and Management of
   Complications From Prosthetic Breast Reconstruction A Systematic Review
   and Meta-analysis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 29th Conference of the European-Wound-Management-Association
CY JUN 05-07, 2019
CL Gothenburg, SWEDEN
SP European Wound Management Assoc
DE negative pressure wound therapy; prosthetic breast reconstruction;
   prosthesis-related complication
ID IMPLANT; SALVAGE; EXPANDER
AB Background Complications from prosthetic breast reconstruction are distressing for patients, and their management is challenging. For decades, negative-pressure wound therapy (NPWT) has been successfully used for the closure of complex wounds. This study analyzes the outcomes of NPWT use in the prevention and management of complications from prosthetic breast reconstruction. Method A systematic search of studies published until August 2020 was conducted using the PubMed/MEDLINE, EMBASE, and Ebscohost/CINAHL databases and using the following key words: "negative-pressure wound therapy," "breast reconstruction," and "prosthesis" (including breast implants and tissue expanders). Analyzed endpoints were outcomes of NPWT use in prosthetic breast reconstruction compared with conventional dressings. The methodological quality of included studies was assessed independently. Comparative studies were further meta-analyzed to obtain pooled odds ratios (ORs) describing the effectiveness of NPWT in prosthetic breast reconstruction. Results/Discussion Ten studies were included with a total of 787 patients (1230 breasts) undergoing prosthetic breast reconstruction with breast implants or tissue expanders. Three case-control studies focused on preventing breast wound complications. The meta-analysis of the 3 studies included 502 breasts receiving NPWT and 698 breasts receiving conventional wound care. The meta-analysis favored NPWT for less mastectomy flap necrosis (5.6% vs 14.3%; OR, 0.46; 95% confidence interval, 0.27 -0.77; P = 0.004; I-2 = 0%) and less overall wound complications (10.6% vs 21.1%; OR, 0.49; 95% confidence interval, 0.35-0.70; P < 0.00001; I-2 = 0%). In the management of nipple-areolar complex venous congestion, 1 case report demonstrated 85% rescue of nipple-areolar complex after using NPWT (-75 mm Hg) for a total of 12 days. In the management of periprosthetic infections, 2 case series used NPWT with instillation. It accelerated the treatment of infection and maintained the breast cavity for future reconstruction. Conventional NPWT also showed good salvage outcome in four studies. Conclusions Current evidence suggests that prophylactic use of NPWT in prosthetic breast reconstruction reduces the rate of overall wound complications and mastectomy flap necrosis. In the management of complications from prosthetic breast reconstructions, NPWT may be a promising option showing beneficial results. Additional high-quality trials are warranted to corroborate the findings of this systematic review.
C1 [Chicco, Maria] Frimley Hlth NHS Fdn Must, Dept Plast & Reconstruct Seger, Wexham Pk Hosp, Slough, Berks, England.
   [Huang, Tony Chieh-Ting] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN USA.
   [Cheng, Hsu-Tang] Asia Univ, Asia Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg,Coll Med & Hlth Sci, 222 Fuxin Rd, Taichung 41354, Taiwan.
   [Cheng, Hsu-Tang] China Med Univ Hosp, Big Data Ctr, Taichung, Taiwan.
C3 Mayo Clinic; Asia University Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Cheng, HT (通讯作者)，Asia Univ, Asia Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg,Coll Med & Hlth Sci, 222 Fuxin Rd, Taichung 41354, Taiwan.
EM hsutangcheng@gmail.com
FU Asia University Hospital Research Program [10851006]; Asia University
   and Asia University Hospital Joint Research Program [ASIA-107-AUH-09];
   China Medical University Hospital Joint Research Program
   [ASIA-108-CMUH-23]; Asia University
FX This study is supported in part by Asia University Hospital Research
   Program (10851006), Asia University and Asia University Hospital Joint
   Research Program (ASIA-107-AUH-09), and Asia University and China
   Medical University Hospital Joint Research Program (ASIA-108-CMUH-23).
CR Accurso A, 2017, AESTHET PLAST SURG, V41, P36, DOI 10.1007/s00266-016-0739-1
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NR 21
TC 13
Z9 17
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2021
VL 87
IS 4
BP 478
EP 483
DI 10.1097/SAP.0000000000002722
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA UU4BB
UT WOS:000698742600031
PM 34060773
DA 2026-07-24
ER

PT J
AU Morani, Z
   Mehta, A
   Parul, F
   Huang, HL
   Khan, MR
   Javaid, N
   Ninan, RS
   Wireko, AA
   Muhammed, L
   Siddiqui, FA
AF Morani, Zoya
   Mehta, Aashna
   Parul, Fnu
   Huang, Helen
   Khan, Mohammad Raza
   Javaid, Nialish
   Ninan, Rachael Suzanne
   Wireko, Andrew Awuah
   Muhammed, Luqman
   Siddiqui, Fatima Aman
TI Benefits of negative pressure wound therapy with fat migration during
   revisional total hip arthroplasty in an obese patient: A case report
SO MEDICINE
LA English
DT Article
DE negative pressure wound therapy; obesity; orthopedic surgery; revisional
   arthroplasty; total hip replacement
ID ADIPONECTIN
AB Introduction: A 38-year-old African American woman presented with right hip pain and movement restriction. Her medical history included a right hip and knee arthroplasty 10 years prior, history of Slipped Capital Femoral Epiphysis and osteonecrosis of the hip. Preoperative assessment was significant for multiple comorbidities such as obesity (BMI > 38), hypertension, asthma.Patient concerns: The patient presented with right hip pain, rated 7/10, and restricted hip flexion, adduction, and abduction.Diagnosis: Recent imaging showed eccentric deterioration of the polyethylene lining of her prosthesis, acetabular hypertrophy on her right hip prosthesis, and chronic deformity of the pubic bone.Interventions: Based on these findings, a revisional total hip arthroplasty was performed. After the surgical procedure, the WoundVAC and the percutaneous drain were applied outside the tensor fascia lata to reduce seroma and hematoma formation. Postoperative pain control, antibiotics and DVT prophylaxis were given. On post-op day 3, an irrigation and debridement with delayed primary wound closure was performed under sterile conditions.Outcomes: On postoperative assessment, the wound demonstrated adequate healing without any signs of infection. Sutures and staples were removed 4 weeks post-op. Upon palpation there was no edema, effusions, temperature changes, tenderness. Clinical inspection revealed symmetrical alignment of the pelvis and hips. Range of motion testing revealed restriction beyond 80 degrees upon flexion and beyond 5 degrees of adduction and 10 degrees of abduction. The surgical site was noted to be healed at 6 weeks post-op. The patient continued to do well to date, without exacerbations.Conclusion: Obesity increases the risk of post-operative complications and wound healing failure. Therefore, Vacuum-assisted wound closure (WoundVAC), a type of negative pressure wound therapy, was applied outside the tensor fascia lata post-operatively, where the surgical incision was made. Negative pressure wound therapy facilitates wound healing by stimulating angiogenesis and promoting granulation tissue formation, which in turn can reduce the risk of surgical site infection in obese patients undergoing total hip arthroplasty. Highlighted is the mechanism of fat migration in the promotion of wound healing after preoperative weight loss and exercise.
C1 [Morani, Zoya; Muhammed, Luqman] Washington Univ Hlth & Sci, San Pedro, Belize.
   [Mehta, Aashna; Ninan, Rachael Suzanne] Univ Debrecen, Fac Med, Debrecen, Hungary.
   [Parul, Fnu] Pandit Bhagwat Dayal Sharma Post Grad Inst Med Sc, Rohtak, India.
   [Huang, Helen] Univ Med & Hlth Sci, Royal Coll Surg Ireland, Dublin, Ireland.
   [Khan, Mohammad Raza] Humboldt Pk Hlth, Chicago, IL USA.
   [Javaid, Nialish; Siddiqui, Fatima Aman] Windsor Univ, Sch Med, Cayon, St Kitts & Nevi.
   [Wireko, Andrew Awuah] Sumy State Univ, Sumy, Ukraine.
C3 University of Debrecen; Pt. B.D. Sharma Post Graduate Institute of
   Medical Sciences (PGIMS), Rohtak; Royal College of Surgeons in Ireland -
   RCSI; Ministry of Education & Science of Ukraine; Sumy State University
RP Wireko, AA (通讯作者)，Sumy State Univ, UA-40000 Sumy, Ukraine.
EM Zoya.morani@gmail.com; aashna.m19@gmail.com; gindraparul@gmail.com;
   HelenHuang@rcsi.ie; MohammadRazaKhan9@gmail.com; Nialishj@gmail.com;
   rachael.ninan@gmail.com; andyvans36@yahoo.com; luqman.mh@gmail.com;
   fatima.siddiqui@student.windsor.edu
RI WIREKO, ANDREW AWUAH/ABD-3005-2021
OI WIREKO, ANDREW AWUAH/0000-0003-2380-2949
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NR 15
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC 29
PY 2023
VL 102
IS 52
AR e36726
DI 10.1097/MD.0000000000036726
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT2R2
UT WOS:001134264400069
PM 38206741
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Du, YP
   Yu, YN
   Xu, SN
   Yang, J
   Liu, Y
   Tang, Y
   Chu, CY
AF Du, Yanping
   Yu, Yanan
   Xu, Shaona
   Yang, Jie
   Liu, Ying
   Tang, Yu
   Chu, Cuiying
TI Antibiotic bone cement combined with vacuum sealing drainage effectively
   repairs sacrococcygeal pressure ulcer
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Antibiotic bone cement; vacuum sealing drainage; sacrococcygeal pressure
   ulcer
ID INJURY
AB Objective: To investigate the effectiveness of antibiotic bone cement combined with the vacuum sealing drainage (VSD) technique for repairing sacrococcygeal pressure ulcer wounds. Methods: A retrospective analysis was conducted on data from 136 patients treated at Yantai Affiliated Hospital of Binzhou Medical College between May 2020 and June 2022. The cases were devided into a control group and a study group according to their treatment regimen. Indicators of postoperative recovery including blood routine recovery time, hospital stay, antibiotic application time, and healing time were compared between the two groups. Before the procedure and 6, 12, 24, and 48 hours following the operation, the pain levels of patients in both groups were examined using a visual analogue scale (VAS). On the 3rd, 7th, 14th, 21st, and 28th days of treatment, the pressure ulcer scale for healing (PUSH) was used to measure the pressure ulcer area between the two groups. On the 7th, 14th, 21st, and 28th days following treatment, the capillary density values were compared between the two groups, along with the levels of interleukin-beta (IL-1 beta), interleukin-12 (IL-12), and C-reactive protein (CRP). The proportions of immunoglobulin M (IgM) and immunoglobulin G (IgG) levels, CD3+, CD4+, and CD8+ T cell subsets, as well as CD4+/CD8+ ratio, were compared between the two groups. Results: The blood routine recovery time, hospital stays, antibiotic usage duration, and healing time were all significantly shorter in the study group compared to those in the control group (all P <0.05). At 6 h, 12 h, 24 h, and 48 h following surgery, the VAS score in study group was significantly lower than that of the control group (P<0.05). P <0.05). The study group also showed a greater reduction in pressure ulcer area, with lower PUSH scores observed on days 14, 21, and 28 (P<0.05). P <0.05). Post-treatment levels of IL-1 beta, IL-12, and CRP decreased in both groups, with significantly lower levels in the study group (P<0.05). P <0.05). Following therapy, both groups demonstrated significantly increased levels of CD3+, CD4+, CD4+/CD8+, IgM and IgG and reduced level of CD8+. These improvements were more pronounced in the study group (all P <0.05). Conclusion: The combination of antibiotic bone cement and VSD is effective in enhancing recovery, reducing pain and inflammation, and improving immune response in the treatment of sacrococcygeal pressure ulcers.
C1 [Du, Yanping; Yu, Yanan; Liu, Ying] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Neurosurg, Yantai 264100, Shandong, Peoples R China.
   [Xu, Shaona] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Spine Surg, Yantai 264100, Shandong, Peoples R China.
   [Yang, Jie] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Endoscopy Ctr, Yantai 264100, Shandong, Peoples R China.
   [Tang, Yu] Binzhou Med Univ, Coll Basic Med, Yantai 264000, Shandong, Peoples R China.
   [Chu, Cuiying] Binzhou Med Univ, Yantai Affiliated Hosp, Dept Trauma Ctr, 717 Jinbu St, Yantai 264100, Shandong, Peoples R China.
C3 Shandong Medical & Pharmaceutical University; Shandong Medical &
   Pharmaceutical University; Shandong Medical & Pharmaceutical University;
   Shandong Medical & Pharmaceutical University; Shandong Medical &
   Pharmaceutical University
RP Chu, CY (通讯作者)，Binzhou Med Univ, Yantai Affiliated Hosp, Dept Trauma Ctr, 717 Jinbu St, Yantai 264100, Shandong, Peoples R China.
EM ytccy9977@163.com
FU Binzhou Medical University, Clinical study of fascial tis-sue combing
   combined with MEBT/MEBO [BY2020XRX010]
FX Acknowledgements This research was supported by Binzhou Medical
   University, Clinical study of fascial tis-sue combing combined with
   MEBT/MEBO to induce the original flavor regeneration of deep wound
   multilayertissues (No. BY2020XRX010) .
CR Anagnostakos Konstantinos, 2017, J Bone Jt Infect, V2, P29, DOI [10.7150/jbji.16067, 10.7150/jbji.16067]
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NR 30
TC 3
Z9 6
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 8
BP 4042
EP 4051
DI 10.62347/RYCD5610
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA E1K7H
UT WOS:001300671800057
PM 39262721
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Cohen, M
   Grevious, M
AF Cohen, M
   Grevious, M
TI The use of muscle flaps for the management of recalcitrant
   gastrointestinal fistulas
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
ID RECTUS-ABDOMINIS MUSCLE; VACUUM-ASSISTED CLOSURE; ENTEROCUTANEOUS
   FISTULA; WALL DEFECT; SMALL-BOWEL; REPAIR; EXPERIENCE; NUTRITION;
   SURGERY; COMPLEX
AB Enterocutaneous fistulas can result from various conditions. Although some heal spontaneously, others persist or recur. This article describes how using muscle flaps may aid in managing recalcitrant gastrointestinal fistulas. Specific cases are cited.
C1 Univ Illinois, Div Plast Surg, Chicago, IL 60612 USA.
   Univ Illinois, Div Reconstruct Surg, Chicago, IL 60612 USA.
   Univ Illinois, Div Cosmet Surg, Chicago, IL 60612 USA.
   John H Stroger Jr Hosp Cook Cty, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; John H Stroger Junior Hospital
   Cook County; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital
RP Cohen, M (通讯作者)，820 S Wood St,M-C 958, Chicago, IL 60612 USA.
EM mncohen@uic.edu
RI /AAN-6268-2020
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NR 24
TC 5
Z9 5
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD APR
PY 2006
VL 33
IS 2
BP 295
EP +
DI 10.1016/j.cps.2005.12.001
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 039AD
UT WOS:000237270500012
PM 16638471
DA 2026-07-24
ER

PT J
AU Li, JH
   Jiang, DW
   Chang, ZQ
AF Li, Jianhua
   Jiang, Dawei
   Chang, Zhengqi
TI Investigating the efficacy of vacuum sealing drainage versus traditional
   negative pressure drainage in treating deep incision infections
   following posterior cervical internal fixation-a retrospective cohort
   study
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Cervical spondylosis; Deep incision infections(DII); Posterior cervical
   internal fixation; Vacuum sealing drainage (VSD); Traditional negative
   pressure drainage (TND)
ID SURGICAL SITE INFECTION; SPINAL INSTRUMENTATION; WOUND-INFECTION;
   RISK-FACTORS; ASSISTED CLOSURE; SURGERY; IRRIGATION; THERAPY; FUSION
AB Background Assessing the efficacy and safety of Vacuum Sealing Drainage (VSD) in treating deep incision infections (DII) following posterior cervical internal fixation. Methods We retrospectively studied the clinical effects of VSD and Traditional Negative Pressure Drainage (TND) on 12 patients with deep incision infection after posterior cervical fixation surgery who were treated in our department from 2012 to 2020. A comparison of patient-related factors (age, gender, BMI, comorbidities, initial internal fixation surgery segment, preoperative laboratory inflammation indicators) and surgical-related factors (postoperative duration of fever, positive rate of drainage fluid bacterial culture, Visual Analogue Scale (VAS) score at 3 days after surgery, laboratory indicators at 3 days after surgery, debridement frequency and drainage time, hospital stay, internal fixation retention rate, and infection recurrence rate) between the VSD group and the TND group was conducted using independent sample t tests to draw experimental conclusions. Results This study included 12 patients, with six cases of VSD (5 males and 1 female) and six cases of TND (4 males and 2 females). The VSD group had significantly lower postoperative fever time (1.50 +/- 0.46 days vs. 4.28 +/- 0.97 days, P < 0.05), a higher positive rate of bacterial cultures in drainage fluid (5/6 vs. 2/6, P < 0.05), lower 3 day VAS scores (3.13 +/- 0.83 vs. 3.44 +/- 0.88, P < 0.05), lower 3 day CRP levels (66.89 +/- 23.65 mg/L vs. 57.11 +/- 18.18 mg/L, P < 0.05), a shorter total drainage time (14.50 +/- 2.98 days vs. 22.56 +/- 3.01 days, P < 0.05), and a higher total drainage flow rate (395.63 +/- 60.97 ml vs. 155.56 +/- 32.54 ml, P < 0.05) than the TND group (the total drainage volume throughout the entire treatment process). In addition, the frequency of debridement (2.67 +/- 0.52 times vs. 3.17 +/- 0.41 times, P < 0.05) and average hospital stay (23.13 +/- 3.27 days vs. 34.33 +/- 6.86 days, P < 0.05) were significantly lower in the VSD group, although both groups retained internal fixation. Conclusions VSD is a secure and effective treatment for deep incision infections that results from cervical posterior internal fixation surgery. Background
C1 [Li, Jianhua; Jiang, Dawei; Chang, Zhengqi] 960th Hosp PLA, Dept Orthopaed Surg, Shifan Rd, Jinan 250031, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthopaed Surg, Shifan Rd, Jinan 250031, Peoples R China.
EM 26766771@qq.com
RI Jiang, Dawei/J-6148-2019
FU Natural Science Foundation of Shandong Province
FX Not applicable.
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NR 37
TC 4
Z9 5
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD FEB 15
PY 2024
VL 29
IS 1
AR 125
DI 10.1186/s40001-024-01717-7
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HZ7G4
UT WOS:001163394300003
PM 38360845
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Daub, C
   Jörger, G
   Kumle, B
   Thielemann, FW
AF Daub, C.
   Joerger, G.
   Kumle, B.
   Thielemann, F. W.
TI Hindquarter amputation -: a solution for pelvic disruption
SO UNFALLCHIRURG
LA German
DT Article
DE traumatic pelvic disruption; hindquarter amputation; vacuum-assisted
   closure; prosthesis; reintegration
ID TRAUMATIC HEMIPELVECTOMY; EMERGENCY-ROOM; INJURIES; RADIOGRAPHY;
   MANAGEMENT
AB Traumatic pelvic disruptions are rare and frequently these injuries are combined with other injuries and have a high lethality. Hindquarter amputation is a lifesaving option and was performed in a 21-year-old motorcyclist with closed pelvic disruption.
C1 [Daub, C.; Joerger, G.; Thielemann, F. W.] Schwarzwald Baar Klinikum Villingen Schwenning Gm, Klin Unfall & Wiederherstellungschirurg, D-78054 Villingen Schwenningen, Germany.
   [Kumle, B.] Schwarzwald Baar Klinikum Villingen Schwenning Gm, Klin Anasthesiol & Intens Med, D-78054 Villingen Schwenningen, Germany.
RP Daub, C (通讯作者)，Schwarzwald Baar Klinikum Villingen Schwenning Gm, Klin Unfall & Wiederherstellungschirurg, Rontgenstr 20, D-78054 Villingen Schwenningen, Germany.
EM Villingen-Schwenningenchdaub@gmx.de
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NR 13
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUL
PY 2008
VL 111
IS 7
BP 545
EP 547
DI 10.1007/s00113-007-1364-x
PG 3
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 325LO
UT WOS:000257590600010
PM 18273593
DA 2026-07-24
ER

PT J
AU Diefenbeck, M
   Mennenga, U
   Gückel, P
   Tiemann, AH
   Mückley, T
   Hofmann, GO
AF Diefenbeck, M.
   Mennenga, U.
   Gueckel, P.
   Tiemann, A. H.
   Mueckley, T.
   Hofmann, G. O.
TI Vacuum-Assisted Closure Therapy for the Treatment of Acute Postoperative
   Osteomyelitis
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE acute posttraumatic/postoperative osteomyelitis; vacuum-assisted closure
   (VAC); serial debridements; osteitis; osteomyelitis
ID GENTAMICIN-PMMA-BEADS; SOFT-TISSUE INJURY; NOSOCOMIAL INFECTIONS;
   SEALING-TECHNIQUE; WOUND THERAPY; IMPLANTS; ALCOHOL; SURGERY; GERMANY;
   TRIAL
AB Aim: Vacuum-assisted closure is used frequently for the treatment of posttraumatic osteomyelitis of the extremities. After debridement and repeated VAC dressing changes, the wounds are closed by secondary suture, split-thickness skin grafts or local flaps. However, no objective parameters describe the time point for secondary wound closure. Our thesis was that negative microbiological results from bone specimens can indicate the time for secondary wound closure. Moreover, treatment course and clinical outcome after 3.4 years should be compared to those of other surgical approaches for acute postoperative osteomyelitis from the literature.
   Patients and Methods: 43 patients with acute postoperative osteomyelitis of the extremities and the pelvis were treated by serial bone and soft tissue debridements and VAC therapy and analysed prospectively. Debridements were repeated until the wounds were macroscopically free from signs of infection (good granulation/no necrosis). During each revision a bone specimen was taken for microbiological analysis. Number of revisions, bacterial cultures, type of wound closure and recurrence of infection after 3 years and 5 months on average after the last surgery was analysed.
   Results: 9.8 debridements on average were performed until eradication of infection and secondary wound closure. Despite the absence of macroscopic infection, bacteria were still found in bone samples from 15 of 43 patients. Three biopsies were free of bacteria for the first time right before wound closure, 25 samples had become negative during the treatment. Six recurrences (19.3%) were noted after 3.4 years on average. Four patients from the group of negative bone biopsies (19%) and two patients from the group of persisting bacteria before secondary closure (20%) had a recurrence of infection.
   Conclusion: In about one third of the bone biopsies bacteria persisted. This bacterial load had no correlation to wound healing and rate of recurrence after over 3 years. In conclusion, microbiological bone samples are not suitable as an indicator for the time point of secondary wound closure. Compared to other treatment options in acute postoperative osteomyelitis from the literature (especially implantation of local antibiotics), no advantage of vacuum-assisted closure could be shown concerning number of debridements and rate of recurrences.
C1 [Diefenbeck, M.; Mueckley, T.; Hofmann, G. O.] Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, D-07747 Jena, Germany.
   [Mennenga, U.; Tiemann, A. H.; Hofmann, G. O.] BG Kliniken Bergmannstrost, Klin Unfall & Wiederherstellungschirurg, Halle, Germany.
   [Gueckel, P.] Exquit Software Solut, Munich, Germany.
C3 Friedrich Schiller University of Jena
RP Diefenbeck, M (通讯作者)，Univ Jena, Klin Unfall Hand & Wiederherstellungschirurg, Erlanger Allee 101, D-07747 Jena, Germany.
EM michael.diefenbeck@med.uni-jena.de
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NR 30
TC 17
Z9 23
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD JUN
PY 2011
VL 149
IS 3
BP 336
EP 341
DI 10.1055/s-0030-1270952
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 778ST
UT WOS:000291726700013
PM 21526465
DA 2026-07-24
ER

PT J
AU Park, KU
   Moquin, K
AF Park, Ko Un
   Moquin, Kenneth
TI Novel Use of External Tissue Expander for Management of Sternal Wound
   Dehiscence
SO ANNALS OF THORACIC SURGERY
LA English
DT Editorial Material
ID VACUUM-ASSISTED CLOSURE; THERAPY
AB Sternal wound dehiscence and its associated complications contribute to significant morbidity and mortality after coronary bypass operations. We present the novel use of continuous external tissue expansion to achieve delayed primary closure of a previously dehisced sternal wound. (C) 2015 by The Society of Thoracic Surgeons
C1 Henry Ford Hlth Syst, Dept Surg, Detroit, MI USA.
   Henry Ford Hlth Syst, Div Plast & Reconstruct Surg, Detroit, MI USA.
C3 Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System;
   Henry Ford Hospital
RP Park, KU (通讯作者)，2799 W Grand Blvd, Detroit, MI 48202 USA.
EM kpark1@hfhs.org
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NR 8
TC 7
Z9 10
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2015
VL 100
IS 4
BP E81
EP E83
DI 10.1016/j.athoracsur.2015.06.044
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CS7TE
UT WOS:000362288000005
PM 26434485
DA 2026-07-24
ER

PT J
AU Phang, ZH
   Khoo, SS
   Gunasagaran, J
   Ahmad, TST
AF Phang, Zi Hao
   Khoo, Saw Sian
   Gunasagaran, Jayaletchumi
   Ahmad, Tunku Sara Tunku
TI Clinical outcome of Maggot Debridement Therapy followed by Negative
   Pressure Wound Therapy for chronic hand wound with Multi-Drug Resistant
   Organism infection: Two cases and review of the literature
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Review
DE maggot; hand; infection; wound; dressing; antibiotic resistance
ID LUCILIA-CUPRINA
AB The advancement in science and research has led to development of medical maggots which feed exclusively on dead tissue. Medical maggots have three important functions namely debridement, disinfection, and stimulation of wound healing. The modern use of medical maggots now goes by the term "Maggot Debridement Therapy" (MDT) for use in wound management. MDT is still used infrequently due to the effectiveness of surgical debridement and antibiotics for treatment of wound infection. Lately, there was emergence of Multi-Drug Resistant Organism (MDRO) likely due to inappropriate antibiotics usage. Maggot secretions have been shown to be effective in inhibiting some MDRO, for example, Methicillin-resistant Staphylococcus aureus, thus making MDT an attractive option for wounds with MDRO. We report two patients with multiple medical comorbidities, diagnosed with serious MDRO Diabetic Hand Infections treated with three cycles of MDT followed by Negative Pressure Wound Therapy.
C1 [Phang, Zi Hao; Khoo, Saw Sian; Gunasagaran, Jayaletchumi; Ahmad, Tunku Sara Tunku] Univ Malaya, Fac Med, Natl Orthopaed Ctr Excellence Res & Learning NOCE, Dept Orthopaed Surg, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Phang, ZH (通讯作者)，Univ Malaya, Fac Med, Natl Orthopaed Ctr Excellence Res & Learning NOCE, Dept Orthopaed Surg, Kuala Lumpur 50603, Malaysia.
EM phangzh@ummc.edu.my
RI Gunasagaran, Jayaletchumi/J-4601-2019; Phang, Zi Hao/AAA-5535-2020;
   Khoo, Saw Sian/ABG-1514-2021; Ahmad, Tunku Sara/B-9979-2010
OI Gunasagaran, Jayaletchumi/0000-0001-5398-6545; Phang, Zi
   Hao/0000-0001-8703-1069; Khoo, Saw Sian/0000-0003-4584-2642; 
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NR 32
TC 4
Z9 6
U1 2
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1022-5536
EI 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PD SEP
PY 2021
VL 29
IS 3
AR 23094990211067302
DI 10.1177/23094990211067302
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA XW6FW
UT WOS:000735713600001
PM 34920683
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sun, XF
   Xie, T
AF Sun, Xiaofang
   Xie, Ting
TI Management of Necrotizing Fasciitis and Its Surgical Aspects
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE necrotizing fasciitis; surgery; debridement; diagnosis; negative
   pressure wound therapy
ID SOFT-TISSUE INFECTIONS; PRESSURE WOUND THERAPY; INTENSIVE-CARE-UNIT;
   FOURNIERS GANGRENE; NEGATIVE-PRESSURE; RETROSPECTIVE ANALYSIS;
   EXPERIENCE; DIAGNOSIS; MORTALITY; CLASSIFICATION
AB Necrotizing fasciitis (NF) is a severe and rapidly progressive infectious disease that attacks superficial an as well as deep fascia, subcutaneous fat tissue, and muscle. Although the incidence is of relatively low frequency, the median mortality is high. NF is a great burden to patients and hospitals. The most common cause of NF is trauma injuries, followed by other conditions with comorbidity. A classification for NF was presented concerning microbial cause, depth of infection, and anatomy. But the value of classification is not convincing. Early diagnosis of NF is essential and still to be realized by far. Information from clinic or laboratory might contribute to the purpose. Surgery is used in exploration debridement and tissue reconstruction as the main method with NF. Negative pressure wound therapy has proved to be useful in improving wound bed preparation and healing.
C1 [Sun, Xiaofang; Xie, Ting] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University
RP Xie, T (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Wound Healing Dept, Shanghai 200011, Peoples R China.
EM doctortingxie@139.com
FU National Natural Science Foundation of China [81071568, 81272111];
   Translational Medical Research Institute Stem Cells and Regenerative
   Medicine Base in Shanghai Jiao Tong University School of Medicine
   [TS201109]; National Scientific & Technology Pillar Program
   [2012BAI11B04]; Major State Basic Research Development Program of China
   [2012CB518100]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by grants from the National Natural Science Foundation of
   China (81071568, 81272111), Translational Medical Research Institute
   Stem Cells and Regenerative Medicine Base in Shanghai Jiao Tong
   University School of Medicine (TS201109), the National Scientific &
   Technology Pillar Program (2012BAI11B04), and the Major State Basic
   Research Development Program of China (2012CB518100).
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NR 50
TC 16
Z9 23
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2015
VL 14
IS 4
BP 328
EP 334
DI 10.1177/1534734615606522
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CZ6WR
UT WOS:000367242200003
PM 26597210
DA 2026-07-24
ER

PT J
AU Rudzka-Nowak, A
   Luczywek, P
   Gajos, MJ
   Piechota, M
AF Rudzka-Nowak, Alina
   Luczywek, Pawel
   Gajos, Maciej Jerzy
   Piechota, Mariusz
TI Application of manuka honey and GENADYNE A4 negative pressure wound
   therapy system in a 55-year-old woman with extensive phlegmonous and
   necrotic lesions in the abdominal integuments and lumbar region after
   traumatic rupture of the colon
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Manuka honey; negative pressure wound therapy system; traumatic rupture
   of the colon
ID ANTIBACTERIAL ACTIVITY; COLORECTAL-CANCER; NEW-ZEALAND; IDENTIFICATION;
   STRAINS; CELLS
AB Background: Antibiotic resistance of bacteria is on the rise and thus, the discovery of alternative therapeutic agents is urgently needed. Honey possesses good therapeutic potential, including wound healing properties and antimicrobial activity.
   Case Report: The authors report on the case of a 55-year-old woman with extensive phlegmonous and necrotic lesions of the abdominal integuments and the lumbar area following traumatic colonic rupture, treated with Manuka honey wound dressings and the GENADYNE A4 negative pressure wound healing system.
   Conclusions: The application of the Manuka honey and the GENADYNE A4 negative pressure wound healing system in treating phlegmonous lesions of the abdominal integuments after rupture of the colon brought good effects, ultimately enabling skin autografting on the wound site and complete wound healing.
C1 [Rudzka-Nowak, Alina; Luczywek, Pawel; Gajos, Maciej Jerzy; Piechota, Mariusz] Univ Hosp Lodz, Mil Med Acad, Dept Anaesthesiol & Intens Therapy, PL-90647 Lodz, Poland.
RP Piechota, M (通讯作者)，Univ Hosp Lodz, Mil Med Acad, Dept Anaesthesiol & Intens Therapy, Hallera Sq 1, PL-90647 Lodz, Poland.
EM mariuszpiechota@poczta.onet.pl
RI Piechota, Mariusz/L-7246-2019
OI Piechota, Mariusz/0000-0002-4269-6742
FU Military Medical Academy University Hospital in Lodz
FX Military Medical Academy University Hospital in Lodz
CR Akouchekian M, 2008, ARCH MED SCI, V4, P249
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NR 26
TC 13
Z9 14
U1 0
U2 6
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PY 2010
VL 16
IS 11
BP CS138
EP CS142
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 677KM
UT WOS:000283991300015
PM 20980964
DA 2026-07-24
ER

PT J
AU Hussain, F
   Lenz, R
AF Hussain, Fahad
   Lenz, Robin
TI Coupling Negative Pressure Wound Therapy with Instillation and
   Split-thickness Skin Grafting to Manage a Large Chronic Venous Leg
   Ulcer: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation; wound care; limb
   salvage; venous wound
ID CLOSURE; COST
AB Introduction. Chronic VLUs are quite challenging to heal with many currently available treatment methods. The timing and combination of treatment methods is integral to successful wound healing. Objective. This case combined NPWTi coupled with biofilm killing solution, hydrosurgical debridement to prepare the wound bed, and STSG to achieve epithelialization. To the knowledge of the authors of the present study, no previously published case report has combined these methods for treatment of a chronic VLU. Case Report. This case report highlights a chronic VLU on the anteromedial ankle that healed in 2 months using NPWTi and STSG. Conclusion. The combination of NPWTi, hydrosurgery, and STSG to treat this patient resulted in successful wound healing, greatly reduced time to healing compared with standard of care, and allowed the patient to return to her normal lifestyle.
C1 [Hussain, Fahad; Lenz, Robin] RWJ Barnabas Hlth, Community Med Ctr, Toms River, NJ USA.
   [Lenz, Robin] Ocean Cty Foot & Ankle Surg Assoc, Toms River, NJ USA.
RP Hussain, F (通讯作者)，Dept Foot & Ankle Surg, 99 NJ-37, Toms River, NJ 08753 USA.
EM fahadhussaindpm@gmail.com
CR Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
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   Millan SB, 2019, AM FAM PHYSICIAN, V100, P298
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NR 14
TC 4
Z9 4
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2023
VL 35
IS 2
BP E59
EP E62
DI 10.25270/wnds/22037
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MK7
UT WOS:001071604700002
PM 36897615
DA 2026-07-24
ER

PT J
AU Saramago, P
   Claxton, K
   Welton, NJ
   Soares, M
AF Saramago, Pedro
   Claxton, Karl
   Welton, Nicky J.
   Soares, Marta
TI Bayesian econometric modelling of observational data for
   cost-effectiveness analysis: establishing the value of negative pressure
   wound therapy in the healing of open surgical wounds
SO JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
LA English
DT Article
DE Economic evaluation; Instrumental variables; Observational data;
   Statistical methods; Surgical wounds
ID INSTRUMENTAL VARIABLE ANALYSIS; HEALTH TECHNOLOGY-ASSESSMENT;
   TASK-FORCE; ELICITATION; DIAGNOSTICS
AB In the absence of evidence from randomized controlled trials on the relative effectiveness of treatments, cost-effectiveness analyses increasingly use observational data instead. Treatment assignment is not, however, randomized, and naive estimates of the treatment effect may be biased. To deal with this bias, one may need to adjust for observed and unobserved confounders. In this work we explore and discuss the challenges of these adjustment strategies within a case-study of negative pressure wound therapy (NPWT) for the treatment of surgical wounds healing by secondary intention. We could not demonstrate that existing uncontrolled confounding affects NPWT effectiveness, and thus there was no evidence that NPWT was cost effective compared with standard dressings for the treatment of surgical wounds healing by secondary intention.
C1 [Saramago, Pedro; Claxton, Karl; Soares, Marta] Univ York, York, N Yorkshire, England.
   [Welton, Nicky J.] Univ Bristol, Bristol, Avon, England.
C3 University of York - UK; University of Bristol
RP Saramago, P (通讯作者)，Univ York, Alcuin Coll, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
EM pedro.saramago@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Welton, Nicky
   J/0000-0003-2198-3205
FU National Institute for Health Research programme grants for applied
   research [RP-PG-0609-10171]; National Institutes of Health Research
   (NIHR) [RP-PG-0609-10171] Funding Source: National Institutes of Health
   Research (NIHR); MRC [MR/P015298/1, MR/K025643/1, MR/R025223/1] Funding
   Source: UKRI; Medical Research Council [MR/K025643/1, MR/P015298/1]
   Funding Source: researchfish; National Institute for Health Research
   [RP-PG-0609-10171] Funding Source: researchfish
FX Funding came from a grant from the National Institute for Health
   Research programme grants for applied research (project
   RP-PG-0609-10171). The funding agreement ensured the authors'
   independence in designing the study, interpreting the data and writing
   and publishing this paper.
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NR 82
TC 4
Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-1998
EI 1467-985X
J9 J ROY STAT SOC A
JI J. R. Stat. Soc. Ser. A-Stat. Soc.
PD OCT
PY 2020
VL 183
IS 4
BP 1575
EP 1593
DI 10.1111/rssa.12596
EA AUG 2020
PG 19
WC Social Sciences, Mathematical Methods; Statistics & Probability
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Mathematical Methods In Social Sciences; Mathematics
GA NW6DA
UT WOS:000555800300001
OA Green Submitted, Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Hill, SM
   Elwood, ET
AF Hill, Sean M.
   Elwood, Eric T.
TI Pediatric Lower Extremity Mower Injuries
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE lower extremity; reconstruction; power mower; pediatric
ID PRESSURE WOUND THERAPY; SOFT-TISSUE INJURIES; CLOSURE; FRACTURES;
   CHILDREN; BRIDGE; TIBIA
AB Lawn mower injuries in children represent an unfortunate common problem to the plastic reconstructive surgeon. There are approximately 68,000 per year reported in the United States. Compounding this problem is the fact that a standard treatment algorithm does not exist. This study follows a series of 7 pediatric patients treated for lower extremity mower injuries by a single plastic surgeon. The extent of soft tissue injury varied. All patients were treated with negative pressure wound therapy as a bridge to definitive closure. Of the 7 patients, 4 required skin grafts, 1 required primary closure, 1 underwent a lower extremity amputation secondary to wounds, and 1 was repaired using a cross-leg flap. Function limitations were minimal for all of our patients after reconstruction. Our basic treatment algorithm is presented with initial debridement followed by the simplest method possible for wound closure using negative pressure wound therapy, if necessary.
C1 [Hill, Sean M.; Elwood, Eric T.] Univ Illinois, Coll Med, Peoria, IL 61656 USA.
C3 University of Illinois System; University of Illinois Peoria
RP Hill, SM (通讯作者)，Univ Illinois, Coll Med, Peoria, IL 61656 USA.
EM shill8@uic.edu
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NR 14
TC 7
Z9 8
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD SEP
PY 2011
VL 67
IS 3
BP 279
EP 287
DI 10.1097/SAP.0b013e3181fab9ba
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 806QW
UT WOS:000293826100018
PM 21508814
DA 2026-07-24
ER

PT J
AU Mueller-Elmau, T
   Friess, H
AF Mueller-Elmau, Tara
   Friess, Helmut
TI Prevention and treatment of surgical site infections in abdominal
   surgery
SO CHIRURGIE
LA German
DT Article
DE Laparotomy; Risk factors; Preventive measures; Wound irrigation;
   Negative pressure wound therapy; Laparotomy; Risk factors; Preventive
   measures; Wound irrigation; Negative pressure wound therapy
ID WOUND-INFECTION; CONSENSUS; TRIAL
AB Postoperative surgical site infections after abdominal surgery are a relevant problem for patients and healthcare systems. Alongside pneumonia and urinary tract infections, surgical site infections are among the most common nosocomial infections in these patients. While the patient-related risk factors are mostly difficult to influence in the short-term, there are some modifiable, surgery-related risk factors (e.g., duration of surgery, sterile technique, blood loss) as well as various perioperative preventive measures with different evidence levels (e.g., skin disinfection, intravenous perioperative antibiotic prophylaxis, use of wound edge protectors, prophylactic wound irrigation, change of instruments and gloves before wound closure, triclosan-coated suture material, negative pressure dressing). Depending on the severity and depth of the infection, the treatment includes opening of the wound, surgical revision with fascial debridement/negative pressure wound therapy or the drainage of intra-abdominal abscesses and appropriate intravenous antibiotics. A relaparotomy for exploration and lavage is indicated in cases of generalized peritonitis.
C1 [Mueller-Elmau, Tara; Friess, Helmut] Univ Klinikum Tech Univ Munchen, Klin & Poliklin Chirurg, Klinikum rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
C3 Technical University of Munich
RP Friess, H (通讯作者)，Univ Klinikum Tech Univ Munchen, Klin & Poliklin Chirurg, Klinikum rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
EM helmut.friess@tum.de
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   KRINKO, 2024, Anforderungen an Hautantiseptika zur Pravention postoperativer Wundinfektionen
   Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft Deutsche Krebshilfe AWMF), 2023, PERIOPERATIVES MANAG
   Maemoto R, 2023, ANN SURG, V277, P727, DOI 10.1097/SLA.0000000000005786
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   Mantyh Christopher, 2024, Eplasty, V24, pe33
   Mihaljevic AL, 2014, ANN SURG, V260, P730, DOI 10.1097/SLA.0000000000000954
   Miyoshi N, 2023, SURG OPEN SCI, V16, P73, DOI 10.1016/j.sopen.2023.09.009
   Mueller T, 2022, TRIALS, V23, DOI 10.1186/s13063-022-06975-6
   Mueller TC, 2024, JAMA SURG, V159, P484, DOI 10.1001/jamasurg.2023.7985
   National Institute for Health and Clinical Excellence (NICE), 2008, SURG SITE INFECTIONP
   Pinkney TD, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4305
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   Strobel RM, 2020, ANN SURG, V272, P55, DOI 10.1097/SLA.0000000000003645
   Takeda M, 2024, SURGERY, V176, P371, DOI 10.1016/j.surg.2024.04.034
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   Willis MA, 2023, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD014909.pub2
   Wolfhagen N, 2022, BJS-BRIT J SURG, V109, P933, DOI 10.1093/bjs/znac196
   World Heath Orgnaization, 2018, Global guidelines for the prevention of surgical site infection
   Zhang XF, 2023, ANN SURG, V278, pE988, DOI 10.1097/SLA.0000000000005939
   Zhao LY, 2023, J HOSP INFECT, V131, P99, DOI 10.1016/j.jhin.2022.10.005
   Zhu Y, 2023, VIDEOSURGERY MINIINV, V18, P541, DOI 10.5114/wiitm.2023.132070
   Zwicky SN, 2022, LANGENBECK ARCH SURG, V407, P3763, DOI 10.1007/s00423-022-02691-6
NR 41
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD APR
PY 2025
VL 96
IS 4
SI SI
BP 347
EP 360
DI 10.1007/s00104-025-02242-x
EA MAR 2025
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0NJ8D
UT WOS:001438958600001
PM 40047908
DA 2026-07-24
ER

PT J
AU Heap, S
   Mehra, S
   Tavakoli, A
   Augustine, T
   Riad, H
   Pararajasingam, R
AF Heap, Sarah
   Mehra, Sanjay
   Tavakoli, Afshin
   Augustine, Titus
   Riad, Hany
   Pararajasingam, Ravi
TI Negative Pressure Wound Therapy Used to Heal Complex Urinary Fistula
   Wounds Following Renal Transplantation into an Ileal Conduit
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
DE Ileal conduit; negative pressure wound therapy; renal transplantation;
   urinary fistula
ID KIDNEY-TRANSPLANTATION
AB Transplantation into an ileal conduit is an established option for patients with end-stage renal failure and a nonfunctioning urinary tract. Urinary fistulae are more common following these complex transplants. Urinary fistula in this scenario can cause substantial morbidity and even result in graft loss. The management options depend on the viability of the transplant ureter, the level of local sepsis and the overall condition of the patient. Urinary diversion with a nephrostomy and ureteric stents has been described in aiding the healing of urinary leaks in renal transplants into a functioning urinary tract. We describe the successful use of negative wound pressure therapy to eradicate the local sepsis and help the healing of a recurrent urinary fistula following kidney transplantation into an ileal conduit. To our knowledge these are the first such cases reported in the literature.
C1 [Heap, Sarah; Mehra, Sanjay; Tavakoli, Afshin; Augustine, Titus; Riad, Hany; Pararajasingam, Ravi] Cent Manchester Univ Hosp, Transplant Unit, Manchester Royal Infirm, Manchester, Lancs, England.
C3 University of Manchester
RP Heap, S (通讯作者)，Cent Manchester Univ Hosp, Transplant Unit, Manchester Royal Infirm, Manchester, Lancs, England.
EM sarahheap@hotmail.co.uk
RI Mehra, Sanjay/MSZ-6822-2025; Augustine, Titus/H-8729-2019
OI Augustine, Titus/0000-0002-7391-1839
CR Nie ZL, 2009, TRANSPL P, V41, P1624, DOI 10.1016/j.transproceed.2008.10.103
   SHESTHA B, 2007, KHATMANDU U MED J, V5, P4
   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Surange RS, 2003, J UROLOGY, V170, P1727, DOI 10.1097/01.ju.0000092023.39043.67
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
   Vikatmaa P, 2008, EUR J VASC ENDOVASC, V36, P438, DOI 10.1016/j.ejvs.2008.06.010
NR 6
TC 7
Z9 10
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD OCT
PY 2010
VL 10
IS 10
BP 2370
EP 2373
DI 10.1111/j.1600-6143.2010.03237.x
PG 4
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 655CN
UT WOS:000282220400027
PM 20738265
OA Green Submitted, Green Published
DA 2026-07-24
ER

PT J
AU Gurvich, L
AF Gurvich, Leon
TI Synergism in Using Negative Pressure Wound Therapy With Alternated
   Applications of Autologous Platelet-derived Growth Factors in Treating
   Post-acute Surgical Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID RICH PLASMA
AB Chronic and acute wounds with long tunneling or undermining are always a challenge to wound care providers. One of the most frequently employed treatments for closing tunneled or undermined wounds is negative pressure wound therapy (NPWT). The benefits of this treatment system are widely discussed in the professional literature, and will not be covered here. Even though NPWT allows for faster wound healing initially, in some cases, progress to wound closure is limited and healing stops after reaching a maximum potential, which may occur after just a few weeks. This adverse phenomenon is more common when the wound exhibits deep tunneling or has been extensively undermined. Trying variations of NPWT strategies geared toward closing these wounds is usually unsuccessful. This article describes cases where combined therapy, using the V.A.C.(R) Therapy System (KCl, San Antonio, Tex) and the autologous platelet-derived gel, AutoloGel (TM), (Cytomedix, Rockville, Md) was employed.
C1 L Weiss Mem Hosp Wound Healing Ctr, Chicago, IL 60640 USA.
RP Gurvich, L (通讯作者)，L Weiss Mem Hosp Wound Healing Ctr, 4646 N Marine Dr, Chicago, IL 60640 USA.
EM leon_gurvich@hotmail.com
CR Carter CA, 2003, EXP MOL PATHOL, V74, P244, DOI 10.1016/S0014-4800(03)00017-0
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Niezgoda JA, 2006, PLAST RECONSTR SURG, V117, p24E, DOI 10.1097/01.prs.0000200776.13868.02
   Pietrzak WS, 2005, J CRANIOFAC SURG, V16, P1043, DOI 10.1097/01.scs.0000186454.07097.bf
   Wrotniak Maciej, 2007, Ortop Traumatol Rehabil, V9, P227
NR 5
TC 7
Z9 8
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2009
VL 21
IS 5
BP 134
EP 140
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 448XL
UT WOS:000266295200005
PM 25903320
DA 2026-07-24
ER

PT J
AU Webb, LX
   Pape, HC
AF Webb, Lawrence X.
   Pape, Hans-Christoph
TI Current Thought Regarding the Mechanism of Action of Negative Pressure
   Wound Therapy With Reticulated Open Cell Foam
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NPWT/ROCF; mechanism of action; VAC; VAC Therapy
ID CLOSURE
AB There arc currently 2 main theories regarding the mechanism of action of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX). The first is based on the stimulatory effect of microstrain on cellular mitogenesis, angiogenesis, and elaboration of growth factors. This is the same mechanism that is operational in controlled Ilizarovian distraction or in tissue expansion. The second is based on the enhancement of the dynamics of microcirculation by active evacuation of excess interstitial fluid in the form of edema. Physiologically, there is a lowering of the heightened capillary afterload and a qualitative dilution of contained microcontaminants, bacteria, and proinflammatory cytokines. Based on these effects, the use of NPWT/ROCF has found a place in the management of high-energy traumatic Wounds and certain high-risk elective surgical wounds.
C1 [Webb, Lawrence X.] Wake Forest Univ, Bowman Gray Sch Med, Div Orthopaed Surg, Dept Orthopaed Surg, Winston Salem, NC 27157 USA.
   [Pape, Hans-Christoph] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Webb, LX (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Div Orthopaed Surg, Dept Orthopaed Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM lxwebb@wfubmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
CR Aronson J, 1997, J BONE JOINT SURG AM, V79A, P1243, DOI 10.2106/00004623-199708000-00019
   BRUMBACK RJ, 1989, LOWER EXTREMITY SALV, P71
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Li Xue-yong, 2007, Zhonghua Shao Shang Za Zhi, V23, P292
   MOLNAR JA, 2004, TOPICAL NEGATIVE PRE
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Norbury K, 2007, WOUNDS, V19, P97
   REDDIX RN, AM J ORTHOP IN PRESS
   REDDIX RN, 2007, ORTH TRAUM ASS ANN M
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   STANNARD JP, 2007, ORTH TRAUM ASS ANN M
   Webb Lawrence X, 2006, J Am Acad Orthop Surg, V14, pS82
NR 12
TC 28
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S135
EP S137
DI 10.1097/BOT.0b013e31818956ce
PG 3
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100003
PM 19034159
DA 2026-07-24
ER

PT J
AU Liu, X
   Zhao, XY
   Shen, GL
   Fan, SW
   Xu, J
   Fan, ZJ
   Li, K
AF Liu, Xiao
   Zhao, Xiaoyu
   Shen, Guoliang
   Fan, Shuwen
   Xu, Jun
   Fan, Zhaojun
   Li, Ke
TI Effect of sinus resection combined with vacuum-assisted closure on
   sacrococcygeal pilonidal sinus
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE sacrococcygeal pilonidal sinus; sinus resection; wound vacuum-assisted
   closure
AB This study was aimed at investigating the effect of sinus removal combined with vacuum-assisted closure in the treatment of sacrococcygeal pilonidal sinus. From January 2019 to May 2022, 62 patients with sacrococcygeal pilonidal sinus were treated and their information was collected at our hospital. These patients were randomly divided into two groups: an observation group (n = 32) and a control group (n = 30). The control group underwent a simple sinus resection and suture, while the observation group received a sinus resection combined with closed negative pressure drainage of the wound. A retrospective analysis of the data obtained was conducted. Perioperative indicators, clinical efficacy, postoperative pain, complications, aesthetic effects, and satisfaction scores at six months after the operation were compared between the two groups, and the recurrence rate at six months after the operation was recorded. Through this study, we found that the observation group had significantly shorter surgery time, hospital stay, and return time compared with the control group (P < 0.05). Additionally, the observation group had a higher overall recurrence rate (ORR) of 100.00%, which was significantly better than the control group's ORR of 86.67% (P < 0.05). The visual analog scale (VAS) score at 6, 12, and 24 h after the operation was significantly lower in the observation group compared with the control group (P < 0.05). Although the differences were not significant (P > 0.05), the observation group had decreased white blood cell, neutrophil, and C-reactive protein levels after the operation. Moreover, the total occurrence rate of postoperative complications in the observation group was significantly lower (6.25%) than that of the control group (26.67%; P < 0.05). The observation group also had significantly lower scores on the postoperative scar scale and higher satisfaction scores than the control group (P < 0.05). However, there was no significant difference in the postoperative recurrence rate between the two groups (P > 0.05). Our study demonstrated that sinus resection combined with vacuum-assisted closure was more effective in treating sacrococcygeal pilonidal sinus compared with simple sinus resection and suture. This approach significantly reduced surgery time, hospital stay, and return time. It also effectively relieved postoperative pain, reduced the occurrence of postoperative complications, resulted in smaller postoperative scars, and yielded better aesthetic outcomes and higher patient satisfaction.
C1 [Liu, Xiao; Zhao, Xiaoyu; Shen, Guoliang; Fan, Shuwen; Xu, Jun; Fan, Zhaojun; Li, Ke] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, Suzhou, Peoples R China.
   [Li, Ke] Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Li, K (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Burn & Plast Surg, 188 Shizi St, Suzhou 215000, Peoples R China.
EM likefggf@163.com
FU Suzhou Science and Technology Plan Projects [SYS2020105]
FX Suzhou Science and Technology Plan Projects, Grant/Award
   Number:SYS2020105
CR Azhough R, 2021, ASIAN J ENDOSC SURG, V14, P458, DOI 10.1111/ases.12893
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   Hannan E, 2021, COLORECTAL DIS, V23, P2961, DOI 10.1111/codi.15890
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   Kanlioz M, 2021, ADV SKIN WOUND CARE, V34, P81, DOI 10.1097/01.ASW.0000725168.11099.92
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   Manigrasso M, 2021, INT J COLORECTAL DIS, V36, P339, DOI 10.1007/s00384-020-03767-9
   Manigrasso M, 2021, J LAPAROENDOSC ADV S, V31, P1, DOI 10.1089/lap.2020.0252
   Marco M, 2011, INT J COLORECTAL DIS, V26, P1601, DOI 10.1007/s00384-011-1242-4
   Mayo O H., 1833, Observations on injuries and disease of rectum, P45
   von Sochaczewski CO, 2021, INT J COLORECTAL DIS, V36, P2135, DOI 10.1007/s00384-021-03944-4
   Yang YP, 2020, INT WOUND J, V17, P555, DOI 10.1111/iwj.13315
   Yildiz A, 2022, ASIAN J SURG, V45, P381, DOI 10.1016/j.asjsur.2021.06.029
   Zubair Rabbia, 2022, J Ayub Med Coll Abbottabad, V34, P230, DOI [10.55519/jamc-02-9371, 10.55519/JAMC-02-9371]
NR 32
TC 3
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD NOV
PY 2023
VL 20
IS 9
BP 3474
EP 3482
DI 10.1111/iwj.14218
EA MAY 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA X7KJ3
UT WOS:000992295200001
PM 37218401
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gopal, SV
   Solomon, A
AF Gopal, Sri Vengadesh
   Solomon, Ashley
TI An inexpensive method of negative pressure wound therapy for extremities
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure; therapy; wound
AB Negative pressure wound therapy (NPWT) is an established method for the faster wound healing of chronic non-healing wounds. It is also used for laparostomy wounds and healing of split skin grafts. The commercially available machine and the consumables for NPWT are very expensive and economically not feasible in developing and underdeveloped countries. So, we devised a NPWT system for wounds of the extremity using inexpensive, readily available materials in any hospital. The materials used are sterile glove, autoclaved sponge, Foley catheter, and a wall suction unit. The sponge was placed over the wound, and a sterile glove was pulled over it. A Foley catheter was placed over the sponge and taken out through one of the fingers of the glove. Adhesive plaster was used to air-seal the glove. The Foley catheter was fixed with silk ties and connected to wall suction. Granulation and wound healing was faster in this system. This system was safe and inexpensive for the treatment of wounds of the extremity.
C1 [Gopal, Sri Vengadesh; Solomon, Ashley] IGMCRI, Dept Gen Surg, Pondicherry 605009, India.
RP Gopal, SV (通讯作者)，IGMCRI, Dept Surg, Pondicherry 605009, India.
EM srivengadesh@gmail.com
CR Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
   Miller Christine, 2012, J Am Coll Clin Wound Spec, V4, P61, DOI 10.1016/j.jccw.2013.11.002
   Ruke M, 2013, J DIABETIC FOOT COMP, V5, P73
   Saraiya HA, 2013, ADV SKIN WOUND CARE, V26, P74, DOI 10.1097/01.ASW.0000426716.51702.29
   Sreelesh LS, 2017, INDIAN J SURG, V79, P81, DOI 10.1007/s12262-017-1589-z
NR 5
TC 4
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2019
VL 16
IS 1
BP 131
EP 133
DI 10.1111/iwj.13002
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HH2FU
UT WOS:000455535100017
PM 30303310
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Meagher, H
   Moloney, MC
   Grace, PA
AF Meagher, H.
   Moloney, M. Clarke
   Grace, P. A.
TI Conservative management of mesh-site infection in hernia repair surgery:
   a case series
SO HERNIA
LA English
DT Article
DE Infected mesh graft; Infected hernia; Conservative management; Negative
   pressure wound therapy; Abdominal hernia repair
ID RANDOMIZED CLINICAL-TRIAL; INCISIONAL HERNIAS; RISK-FACTORS;
   METAANALYSIS; PROSTHESIS; SUTURE
AB The aim of this study is to assess the outcome of conservative management of infected mesh grafts following abdominal wall hernia repair.
   This study retrospectively examined the charts of patients who developed mesh-site infection following surgery for abdominal hernia repair to determine how effective conservative management in the form of antibiotics and wound management was on the resolution of infection and wound healing.
   Over a period of 30 months, 13 patients developed infected mesh grafts post-hernia repair surgery. Twelve patients were successfully treated conservatively with local wound care and antibiotics if clinically indicated. One patient returned to theatre to have the infected mesh removed. Of the patients that healed eleven were treated with negative pressure wound therapy (VAC(A (R))).
   This series of case studies indicate that conservative management of abdominal wall-infected hernia mesh cases is likely to be successful.
C1 [Meagher, H.] Univ Hosp Limerick, Dept Nursing, Limerick, Ireland.
   [Moloney, M. Clarke; Grace, P. A.] Univ Hosp Limerick, Vasc Res Unit, Limerick, Ireland.
C3 University of Limerick; University of Limerick
RP Moloney, MC (通讯作者)，Univ Hosp Limerick, Vasc Res Unit, Limerick, Ireland.
EM mary.clarkemoloney@hse.ie
CR Aguilar B, 2010, J LAPAROENDOSC ADV S, V20, P249, DOI 10.1089/lap.2009.0274
   [Anonymous], AG FAST INCR OLD OLD
   [Anonymous], SURG INF PREV TREAT
   [Anonymous], J AYUB MED COLL ABBO
   [Anonymous], 2010, J Am Coll Surg
   [Anonymous], SURGERY
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   Szczerba SR, 2003, ANN SURG, V237, P437, DOI 10.1097/00000658-200303000-00020
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   Vrijland WW, 2002, BRIT J SURG, V89, P293, DOI 10.1046/j.0007-1323.2001.02030.x
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 40
TC 32
Z9 45
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2015
VL 19
IS 2
BP 231
EP 237
DI 10.1007/s10029-013-1069-8
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE3BS
UT WOS:000351699800008
PM 23504138
DA 2026-07-24
ER

PT J
AU de Runz, A
   Zuily, S
   Gosset, J
   Wahl, D
   Simon, E
AF de Runz, Antoine
   Zuily, Stephane
   Gosset, Jessica
   Wahl, Denis
   Simon, Etienne
TI Particular catastrophic antiphospholipid syndrome, on the sole surgical
   site after breast reduction
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Mammaplasty; Antiphospholipid syndrome; Skin necrosis; Negative-pressure
   wound therapy; Skin transplantation; Skin artificial
ID PRESSURE WOUND THERAPY
AB A 20-year-old woman treated with vitamin K antagonist for antiphospholipid syndrome (APS) (pulmonary embolisms at age 15) was admitted for breast reduction after bridging therapy. At 2 days post-surgery haematomas appeared on the surgical site and anticoagulant therapy was withheld. She developed a skin and breast necrosis leading to the diagnosis of catastrophic APS. Despite medical treatment (anticoagulant therapy, corticosteroids and intravenous immunoglobulins) and surgery, necrosis continued. After 2 weeks of negative-pressure wound therapy (V.A.C.(R) Therapy (TM)) the patient improved, mammary tissues were alive, well vascularised and budding. Breast reconstruction was then initiated. Artificial dermis graft (MatriDerm (R) 2 mm) was applied, and 3 weeks later the apposition of split-thickness skin graft on it. Six months later, results of the surgery were good and the patient was satisfied. (C) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [de Runz, Antoine; Simon, Etienne] Nancy Univ Hosp, Dept Maxillofacial Plast Reconstruct & Cosmet Sur, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] Nancy Univ Hosp, Vasc Med Div, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] Nancy Univ Hosp, Reg Competence Ctr Rare Vasc & Syst Autoimmune Di, Nancy, France.
   [Zuily, Stephane; Wahl, Denis; Simon, Etienne] Univ Lorraine, Nancy, France.
   [Zuily, Stephane; Wahl, Denis] INSERM, UMR S 1116, Nancy, France.
   [Gosset, Jessica] Clin Villa Isabey, Nancy, France.
C3 CHU de Nancy; CHU de Nancy; CHU de Nancy; Universite de Lorraine;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine
RP de Runz, A (通讯作者)，Serv Chirurg Maxillofaciale Plast Reconstructrice, 29 Ave Marechal de Lattre de Tassigny, F-54000 Nancy, France.
EM antoine@email.com
OI de Runz, Antoine/0000-0003-1213-0710
CR Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Cervera R, 2009, J AUTOIMMUN, V32, P240, DOI 10.1016/j.jaut.2009.02.008
   Eisenhardt SU, 2012, J PLAST RECONSTR AES, V65, P640, DOI 10.1016/j.bjps.2011.11.037
   Erkan D, 2010, AUTOIMMUN REV, V10, P74, DOI 10.1016/j.autrev.2010.08.005
   Jacobs S, 2009, J PLAST RECONSTR AES, V62, P1331, DOI 10.1016/j.bjps.2008.03.024
   Kasai Y, 2012, J PLAST RECONSTR AES, V65, P395, DOI 10.1016/j.bjps.2011.08.010
   Kiney AV, 2008, LUPUS, V17, P952, DOI 10.1177/0961203308096662
NR 7
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2013
VL 66
IS 11
BP E321
EP E324
DI 10.1016/j.bjps.2013.04.037
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 232CM
UT WOS:000325466700006
PM 23680115
DA 2026-07-24
ER

PT J
AU Schurtz, E
   Differding, J
   Jacobson, E
   Maki, C
   Ahmeti, M
AF Schurtz, Elleson
   Differding, Jerome
   Jacobson, Eric
   Maki, Christopher
   Ahmeti, Mentor
TI Evaluation of negative pressure wound therapy to closed laparotomy
   incisions in acute care surgery
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID HIGH-RISK
AB Background: Surgical site complications in the form of wound infections are a major burden to the healthcare system. Negative pressure wound therapy (NPWT) as delivered by a surgical incision management system (SIMS) is a novel approach to improve wound healing when applied to closed incisions. However, data is limited in its application to laparotomy incisions in the acute care surgery setting.
   Methods: A retrospective case-control study was performed to evaluate the outcomes of SIMS with regard to surgical site infections in a series of 48 consecutive patients in which SIMS was applied to closed laparotomy incisions in the acute care surgery setting.
   Results: 48 cases were matched with equivalent controls without significant differences between groups. Patients who received the SIMS had significantly lower rates of surgical site infection and readmission rates.
   Conclusions: Negative pressure surgical incision management systems may be a novel approach to reduce surgical site infections in acute care surgery. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Schurtz, Elleson; Maki, Christopher] Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58202 USA.
   [Differding, Jerome; Jacobson, Eric; Ahmeti, Mentor] Sanford Med Ctr, Fargo, ND USA.
C3 University of North Dakota Grand Forks; Sanford Health
RP Schurtz, E (通讯作者)，Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58202 USA.
EM eschurtz@gmail.com
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Carlson JW, 2008, GYNECOL ONCOL, V111, pS98, DOI 10.1016/j.ygyno.2008.08.010
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Ingargiola Michael J, 2013, Eplasty, V13, pe49
   Masden D, 2012, ANN SURG, V255, P1043, DOI 10.1097/SLA.0b013e3182501bae
   Matatov T, 2013, J VASC SURG, V57, P791, DOI 10.1016/j.jvs.2012.09.037
   National Healthcare Safety Network Centers for Disease Control and Prevention, 2017, Surgical site infection (SSI) event
   O'Leary D, 2017, ANN SURG, V265
   Perencevich EN, 2003, EMERG INFECT DIS, V9, P196
   Scalise A, 2015, INT WOUND J, V12, P218, DOI 10.1111/iwj.12370
   Solowiej K, 2010, J WOUND CARE, V19, P110, DOI 10.12968/jowc.2010.19.3.47280
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   Suh H, 2016, ANN PLAS SURG, V76, P717, DOI 10.1097/SAP.0000000000000231
NR 14
TC 35
Z9 38
U1 0
U2 5
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JAN
PY 2018
VL 215
IS 1
BP 113
EP 115
DI 10.1016/j.amjsurg.2017.08.009
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FP4SP
UT WOS:000417607000021
PM 28882357
DA 2026-07-24
ER

PT J
AU Takagi, S
   Oyama, T
   Jimi, S
   Saparov, A
   Ohjimi, H
AF Takagi, Satoshi
   Oyama, Takuto
   Jimi, Shiro
   Saparov, Arman
   Ohjimi, Hiroyuki
TI A Novel Autologous Micrografts Technology in Combination with Negative
   Pressure Wound Therapy (NPWT) for Quick Granulation Tissue Formation in
   Chronic/Refractory Ulcer
SO HEALTHCARE
LA English
DT Article
DE regenerative medicine; chronic wounds; micrografts
AB Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for initiating wound healing. The case presented is of a patient with a lower leg ulcer that had responded poorly to NPWT alone for three weeks. Consequently, the patient was put on a combination therapy of NPWT and micrografting. After injection of a dermal tissue micrografts suspension into the entire wound bed, NPWT was performed successively for two weeks, resulting in fresh granulation tissue formation. Thereafter, the autologous skin graft was taken well. This case study indicates that for a chronic/refractory ulcer patient with poor NPWT outcome, combination therapy using micrografting treatment and NPWT could rapidly initiate and enhance granulation tissue formation, creating a favorable bedding for subsequent skin grafting.
C1 [Takagi, Satoshi; Oyama, Takuto; Ohjimi, Hiroyuki] Fukuoka Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Fukuoka 8140180, Japan.
   [Jimi, Shiro] Fukuoka Univ, Fac Med, Cent Lab Pathol & Morphol, Fukuoka 8140180, Japan.
   [Saparov, Arman] Nazarbayev Univ, Sch Med, Dept Med, Nur Sultan 010000, Kazakhstan.
C3 Fukuoka University; Fukuoka University; Nazarbayev University
RP Takagi, S (通讯作者)，Fukuoka Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Fukuoka 8140180, Japan.
EM stakagi@fukuoka-u.ac.jp; oyt1974@yahoo.co.jp; sjimi@fukuoka-u.ac.jp;
   asaparov@nu.edu.kz; ohjimi@fukuoka-u.ac.jp
OI Saparov, Arman/0000-0002-4407-1236; Takagi, Satoshi/0000-0003-4052-4522
CR Alvarez X, 2017, Int. J. Res. Studies Med. Health Sci, V2, P19
   Andreone A, 2019, STEM CELLS INT, V2019, DOI 10.1155/2019/8636079
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   Riccio M, 2019, STEM CELLS INT, V2019, DOI 10.1155/2019/5043518
   Ruiz RG, 2020, J CELL PHYSIOL, V235, P4587, DOI 10.1002/jcp.29335
   Shah A, 2019, ANN PLAS SURG, V82, pS222, DOI 10.1097/SAP.0000000000001842
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   Yang SL, 2017, FOOT ANKLE INT, V38, P893, DOI 10.1177/1071100717704940
NR 25
TC 10
Z9 11
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD DEC
PY 2020
VL 8
IS 4
AR 513
DI 10.3390/healthcare8040513
PG 6
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA PJ0IR
UT WOS:000601463700001
PM 33255590
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Tang, JJ
   Tao, GL
   Liu, YK
   Ma, X
   Aobuliaximu, Y
   Lu, SL
AF Tang, JiaJun
   Tao, Guilu
   Liu, Yingkai
   Ma, Xian
   Aobuliaximu, Yakupu
   Lu, Shuliang
TI CO2Laser Debridement and Negative Pressure Wound Therapy With
   Endoscopic Support for Treatment of Sinus Wound at the Ischial
   Tuberosity: Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE CO(2)laser; negative ressure wound therapy; endoscopy; sinus wound;
   ischial tuberosity
AB The sinus tract of the ischial tuberosity is often caused by pressure injury. It has the characteristics of difficult treatment and high cost, which increases the anxiety of patients and reduces the quality of life of patients. This case report is to describe an effective method to treat sinus wound at the ischial tuberosity. A 53-year-old male suffered pressure ulcer with sinus wound at the left ischial tuberosity due to inadequate walking and sedentary activity. On the basis of pressure relief and immobilization, the patient was treated with CO(2)laser debridement and negative pressure wound therapy under endoscope support 3 times, the deep of the sinus wound was completely closed, and then the residual superficial wound was treated by skin grafting. Follow-up of 1 year after healing showed no recurrence of wound.
C1 [Tang, JiaJun; Tao, Guilu; Liu, Yingkai; Ma, Xian; Aobuliaximu, Yakupu; Lu, Shuliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Lu, SL (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Wound Healing Ctr, Sch Med, Shanghai 200025, Peoples R China.
EM 13901738685@139.com
RI Tang, JiaJun/J-1320-2014
CR Brienza D, 2010, J AM GERIATR SOC, V58, P2308, DOI 10.1111/j.1532-5415.2010.03168.x
   Byun HongSeob Byun HongSeob, 2013, Journal of Veterinary Clinics, V30, P247
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   Pelizzo G, 2018, J STEM CELLS REGEN, V14, pP53, DOI 10.46582/jsrm.1401007
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   Stockton Lesley, 2002, J Tissue Viability, V12, P88
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   Zhang X, 2016, HUAXI MED, V31, P2024
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   Zhou L, 2017, GEN NURS, V15, P1821
NR 15
TC 2
Z9 2
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2022
VL 21
IS 3
BP 337
EP 341
AR 1534734620953674
DI 10.1177/1534734620953674
EA SEP 2020
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3B8DC
UT WOS:000566911200001
PM 32883117
DA 2026-07-24
ER

PT J
AU Bovill, E
   Banwell, PE
   Teot, L
   Eriksson, E
   Song, C
   Mahoney, J
   Gustafsson, R
   Horch, R
   Deva, A
   Whitworth, I
AF Bovill, Estas
   Banwell, Paul E.
   Teot, Luc
   Eriksson, Elof
   Song, Colin
   Mahoney, Jim
   Gustafsson, Ronny
   Horch, Raymund
   Deva, Anand
   Whitworth, Ian
CA Int Advisory Panel Topical
TI Topical negative pressure wound therapy: a review of its role and
   guidelines for its use in the management of acute wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Acute wound; Negative pressure wound therapy; Topical negative pressure
AB Over the past two decades, topical negative pressure (TNP) wound therapy has gained wide acceptance as a genuine strategy in the treatment algorithm for a wide variety of acute and chronic wounds. Although extensive experimental and clinical evidence exists to support its use and despite the recent emergence of randomised control trials, its role and indications have yet to be fully determined. This article provides a qualitative overview of the published literature appertaining to the use of TNP therapy in the management of acute wounds by an international panel of experts using standard methods of appraisal. Particular focus is applied to the use of TNP for the open abdomen, sternal wounds, lower limb trauma, burns and tissue coverage with grafts and dermal substitutes. We provide evidence-based recommendations for indications and techniques in TNP wound therapy and, where studies are insufficient, consensus on best practice.
C1 [Banwell, Paul E.] Queen Victoria Hosp, Dept Plast & Reconstruct Surg, E Grinstead RH19 3DZ, W Sussex, England.
   [Bovill, Estas] Derriford Hosp, Dept Plast & Reconstruct Surg, Plymouth PL6 8DH, Devon, England.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast & Burns Surg, Montpellier, France.
   [Eriksson, Elof] Harvard Univ, Sch Med, Div Plast Surg, Boston, MA USA.
   [Eriksson, Elof] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Song, Colin] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 0316, Singapore.
   [Mahoney, Jim] Univ Toronto, Div Plast Surg, Toronto, ON, Canada.
   [Gustafsson, Ronny] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Horch, Raymund] Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
   [Deva, Anand] Univ New S Wales, Dept Plast & Reconstruct Surg, Sydney, NSW, Australia.
   [Whitworth, Ian] Salisbury Dist Hosp, Salisbury, Wilts, England.
C3 Derriford Hospital; Universite de Montpellier; CHU de Montpellier;
   Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Singapore
   General Hospital; University of Toronto; Lund University; Skane
   University Hospital; University of Erlangen Nuremberg; University of New
   South Wales Sydney; Salisbury District Hospital
RP Banwell, PE (通讯作者)，Queen Victoria Hosp, Dept Plast & Reconstruct Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
EM paul.banwell@qvh.nhs.uk
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Deva, Anand/0000-0002-0314-7177
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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NR 125
TC 85
Z9 100
U1 3
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2008
VL 5
IS 4
BP 511
EP 529
DI 10.1111/j.1742-481X.2008.00437.x
PG 19
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BD
UT WOS:000207844200005
PM 18808432
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Bilgin, IA
   Bas, M
   Demir, S
   Esen, E
   Kirbiyik, E
   Aghayeva, A
   Ozben, V
   Aytac, E
   Baca, B
   Hamzaoglu, I
   Karahasanoglu, T
AF Bilgin, Ismail Ahmet
   Bas, Mustafa
   Demir, Sehri
   Esen, Eren
   Kirbiyik, Ebru
   Aghayeva, Afag
   Ozben, Volkan
   Aytac, Erman
   Baca, Bilgi
   Hamzaoglu, Ismail
   Karahasanoglu, Tayfun
TI Management of Complicated Ostomy Dehiscence A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Autolytic debridement; Complex colorectal surgery; Negative pressure
   wound therapy; Ostomy; Silver dressings; Stoma; Wound dehiscence; Wound
   management
ID QUALITY-OF-LIFE
AB BACKGROUND:
   Stoma creation is a common procedure in colorectal surgery. Despite improved surgical techniques, ostomy-related wound complications may prolong the recovery period and impair health-related quality of life. Negative pressure wound therapy (NPWT), autolytic debridement agents, and silver dressings are often used for managing complex wound infection and dehiscence. These applications have the potential to increase patient comfort and accelerate recovery.
   CASE:
   We report our experience in a 66 year old female who had a wound dehiscence involving the ostomy after robotic abdominoperineal resection. Her medical history was significant for a rectovaginal fistula which occurred after a low anterior resection for rectal cancer 5 years ago. Interventions for treatment of the dehiscence were use of NPWT, autolytic debriding agent, and silver dressing.
   CONCLUSION:
   Combined use of these interventions for dehiscence of an ostomy can minimize patient discomfort and accelerate wound healing.
C1 [Bilgin, Ismail Ahmet; Bas, Mustafa; Demir, Sehri; Esen, Eren; Kirbiyik, Ebru; Aghayeva, Afag; Ozben, Volkan; Aytac, Erman; Baca, Bilgi; Hamzaoglu, Ismail; Karahasanoglu, Tayfun] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Gen Surg, Darussafaka Mahallesi,Buyukdere Cd 40, TR-34457 Istanbul, Turkey.
   [Bas, Mustafa] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Istanbul, Turkey.
C3 Acibadem University; Istanbul University - Cerrahpasa
RP Bilgin, IA (通讯作者)，Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Gen Surg, Darussafaka Mahallesi,Buyukdere Cd 40, TR-34457 Istanbul, Turkey.
EM isahbilgin@hotmail.com
RI ; hamzaoglu, ismail/F-5400-2016; Aytac, Erman/HLW-2224-2023; Esen,
   Eren/AAF-3624-2021
OI Baş, Mustafa/0009-0004-3622-1187; 
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NR 16
TC 1
Z9 3
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JAN-FEB
PY 2020
VL 47
IS 1
BP 72
EP 74
DI 10.1097/WON.0000000000000611
PG 3
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KL0VK
UT WOS:000513150500011
PM 31929448
DA 2026-07-24
ER

PT J
AU Espinosa-de-los-Monteros, A
   Mosqueda-Larrauri, VL
   Sanchez-Pereda, D
   Gamboa-Lopez, CA
AF Espinosa-de-los-Monteros, Antonio
   Mosqueda-Larrauri, Virna Lisi
   Sanchez-Pereda, Diego
   Gamboa-Lopez, Christian Alessandro
TI Postoperative Outcomes of Incisional Negative Pressure Wound Therapy in
   Patients Undergoing Abdominoplasty, Horizontal Panniculectomy, or
   Harvest of TRAM or DIEP Flaps
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominoplasty; panniculectomy; transversus abdominis flap; deep
   inferior epigastric perforator flap; negative pressure wound therapy
ID ABDOMINAL DONOR-SITE; VENTRAL HERNIA REPAIR; BREAST RECONSTRUCTION;
   SPINAL-FUSION; COMPLICATIONS
AB Abdominoplasty, horizontal panniculectomy and TRAM/DIEP flaps can sometimes be associated to postoperative complications such as wound dehiscence, skin necrosis, seroma, hematoma, surgical site infection, and need for unplanned reoperation. The purpose of this study is to provide an estimate of the clinical effects that iNPWT has on those outcomes, based on the available literature. Twelve studies met the inclusion criteria and were included in the systematic review. From these, 11 studies were comparative and suitable for meta-analysis. Results showed that the use of iNPWT is associated to a significant decrease in the rates of postoperative wound dehiscence and need for unplanned reoperation. There was no statistically significant difference in the rates of postoperative skin necrosis, seroma, hematoma, and surgical site infection.
C1 [Espinosa-de-los-Monteros, Antonio; Mosqueda-Larrauri, Virna Lisi; Sanchez-Pereda, Diego; Gamboa-Lopez, Christian Alessandro] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Div Plast Surg, Vasco Quiroga 15, Mexico City 14000, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Espinosa-de-los-Monteros, A (通讯作者)，Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Div Plast Surg, Vasco Quiroga 15, Mexico City 14000, DF, Mexico.
EM aedlms@hotmail.com; vmosquedalarrauri@gmail.com;
   sanchezperedadiego@gmail.com; christiangamboamd@gmail.com
OI Gamboa Lopez, Christian Alessano/0009-0003-8398-4171
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2025
VL 95
IS 6
BP 752
EP 759
DI 10.1097/SAP.0000000000004478
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A4085
UT WOS:001619491700011
PM 41133907
DA 2026-07-24
ER

PT J
AU Willy, C
AF Willy, Christian
TI Breakthrough ideas leading to new futures: prologue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Editorial Material
DE Instillation; Negative pressure wound therapy; Vacuum therapy; Wound
   cleansing
AB Since commercialisation almost 20 years ago, negative pressure wound therapy (NPWT; V.A.C.(R) Therapy; KCI USA, Inc., San Antonio, TX) has been used to treat a wide variety of wound types and continues to evolve as research expands understanding of the mechanisms of action that enable this adjunct therapy to facilitate wound closure. In 2010, the educational International Surgical Wound Forum (ISWF) was created to facilitate discussion among experts from all over the world regarding modern wound treatment challenges and techniques. This is the first of two supplements, which are based on the 2012 and 2013 ISWF presentations and demonstrate the evolution of the role of NPWT in wound care. This first supplement provides an overview of current health care challenges and clinical practice and reviews evidence and experience using NPWT with instillation, which combines NPWT with computer-controlled delivery and removal of topical solutions and suspensions to cleanse and/or treat wounds.
C1 [Willy, Christian] Bundeswehrkrankenhaus Berlin, Dept Traumatol & Orthopaed, D-10115 Berlin, Germany.
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Colonel Dept Traumatol & Orthopaed, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
NR 0
TC 2
Z9 2
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 1
EP 2
DI 10.1111/iwj.12177
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300001
PM 24251836
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Stucke, C
   Reeves, L
   Haycock, D
AF Stucke, Christopher
   Reeves, Lance
   Haycock, Darryl
TI An Innovative Approach to Calcaneal Decubitus Ulcerations Through
   Calcaneal Decorticalization with Use of Localized Bone Marrow and
   Negative-Pressure Wound Therapy A Case Study
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID HEEL; MANAGEMENT; ALGORITHM
AB Heel decubitus ulcerations are relatively common occurrences that can be limb threatening. There are many options to treat these ulcerations, ranging from conservative wound care to serial debridement with flap reconstruction. However, not all patients are good candidates for major reconstructive surgery. In this case, we present a 46-year-old man who failed 3 months of conservative wound care after sustaining a heel decubitus ulcer because of immobilization from a motor vehicle accident. The ulceration was treated with sharp excision of the wound with calcaneal decorticalization and use of negative-pressure wound therapy to use the localized bone marrow within the wound bed. The patient went on to heal within 3 months of operative intervention and remains healed greater than 1 year postoperatively. This technique provided the ability to use localized bone marrow to assist in wound healing without the operative morbidity of a reconstructive procedure. (J Am Podiatr Med Assoc 112(2), 2022)
C1 [Stucke, Christopher; Reeves, Lance] Mercy Hlth St Ritas Med Ctr, Lima, OH USA.
   [Reeves, Lance] West Cent Ohio Podiatry, Lima, OH USA.
   [Stucke, Christopher] Grand Lake Foot & Ankle Ctr, St Marys, OH USA.
   [Haycock, Darryl] Haycock Foot & Ankle Ctr, Lima, OH USA.
   [Reeves, Lance] West Cent Ohio Podiatry, 1138 High St, Lima, OH 45805 USA.
RP Reeves, L (通讯作者)，West Cent Ohio Podiatry, 1138 High St, Lima, OH 45805 USA.
EM Lancereeves13@gmail.com
CR Badiavas EV, 2003, ARCH DERMATOL, V139, P510, DOI 10.1001/archderm.139.4.510
   Bingol UA, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/785819
   Boffeli TJ, 2013, J FOOT ANKLE SURG, V52, P107, DOI 10.1053/j.jfas.2012.06.018
   Boyko TV, 2018, ADV WOUND CARE, V7, P57, DOI 10.1089/wound.2016.0697
   Brucato MP, 2019, J FOOT ANKLE SURG, V58, P591, DOI 10.1053/j.jfas.2018.09.016
   Chittoria RK, 2016, ADV WOUND CARE, V5, P102, DOI 10.1089/wound.2014.0612
   Edsberg LE, 2016, J WOUND OSTOMY CONT, V43, P585, DOI 10.1097/WON.0000000000000281
   El-Shazly M, 2008, J FOOT ANKLE SURG, V47, P145, DOI 10.1053/j.jfas.2007.12.010
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   Goudie EB, 2012, INT WOUND J, V9, P132, DOI 10.1111/j.1742-481X.2011.00869.x
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   Oliver NG, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/432164
NR 13
TC 0
Z9 0
U1 0
U2 0
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2022
VL 112
IS 2
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z4SB4
UT WOS:001111980300005
DA 2026-07-24
ER

PT J
AU Kirsner, RS
   Romanelli, M
AF Kirsner, Robert S.
   Romanelli, Marco
TI Use of advanced technologies across the wound care spectrum: prologue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wounds; Epidermal skin grafts; Negative pressure wound therapy;
   Wound healing
ID VENOUS LEG ULCERS; FOOT ULCERS; BURDEN
AB The growing trends of ageing populations and increasing prevalence of diabetes have given rise to an expanding number of problematic acute and chronic wounds. Over the past two decades, the use of negative pressure wound therapy (NPWT) with and without instillation of topical wound solutions has expanded to include treatment of a large variety of wounds. Additionally, the use of NPWT specifically designed for use over closed surgical incisions has been associated with favourable results. The recent introduction of an automated epidermal harvesting system, which neither creates a donor site wound nor requires the use of a surgeon, operating room or anaesthesia, has facilitated the use of epidermal grafting. This supplement highlights some of the advanced wound approaches that have been developed to address challenging wounds and the growing burden of wound care affecting both the patient and the health care system.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
   [Romanelli, Marco] Univ Pisa, Dept Dermatol, Wound Healing Res Unit, Pisa, Italy.
C3 University of Miami; University of Pisa
RP Kirsner, RS (通讯作者)，Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, 1600 NW 10th Ave Rosenstiel Med Sci Bldg, Miami, FL 33136 USA.
EM Rkirsner@miami.edu
RI romanelli, marco/ABI-1154-2020
OI romanelli, marco/0000-0002-4127-0141
FU ACELITY
FX Drs. Kirsner and Romanelli served as consultants to KCI, an ACELITY
   Company, and presented as faculty members at an ACELITY symposium held
   in conjunction with the 2016 World Union of Wound Healing Societies
   (WUWHS) conference. This article is part of an ACELITY-funded supplement
   based on the 2016 WUWHS ACELITY symposium presentations. ACELITY
   provided editorial assistance.
CR Alavi A, 2016, J AM ACAD DERMATOL, V74, P644, DOI 10.1016/j.jaad.2015.03.059
   Armstrong David G, 2007, Int Wound J, V4, P286
   Eaglstein WH, 2012, WOUND REPAIR REGEN, V20, P793, DOI 10.1111/j.1524-475X.2012.00849.x
   Lyder C.H., 2008, Patient safety and quality: An evidence-based handbook for nurses, p1
   Martins-Mendes D, 2014, J DIABETES COMPLICAT, V28, P632, DOI 10.1016/j.jdiacomp.2014.04.011
   Nole KLB, 2015, JAMA DERMATOL, V151, P583, DOI 10.1001/jamadermatol.2014.5112
   Redelings Matthew D, 2005, Adv Skin Wound Care, V18, P367, DOI 10.1097/00129334-200509000-00010
   Rice J Bradford, 2014, J Med Econ, V17, P347, DOI 10.3111/13696998.2014.903258
   Rice JB, 2014, DIABETES CARE, V37, P651, DOI 10.2337/dc13-2176
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
NR 11
TC 2
Z9 3
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 5
EP 7
DI 10.1111/iwj.12633
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700001
PM 27547957
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kuffler, DP
AF Kuffler, Damien P.
TI Improving the ability to eliminate wounds and pressure ulcers
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PLATELET-RICH PLASMA; LOW-LEVEL LASER; VACUUM-ASSISTED CLOSURE; DIABETIC
   FOOT ULCERS; NERVE GROWTH-FACTOR; ELECTRICAL-STIMULATION; LIGHT THERAPY;
   SKIN FLAPS; SURVIVAL; TISSUE
AB Pressure ulcers can be initiated by as little as 2 hours of constant pressure on the ski, that blocks blood circulation causing the skin and underlying tissues to die, leading to an open wound that never heals, but continues to grow in diameter and depth, and frequently jeopardizes patients' lives. Despite the application of many diverse techniques, pressure ulcers remain exceptionally difficult to heal because many ulcer elimination techniques have minimal effects, and although other techniques may appear to be effective, the evidence supporting their efficacy is weak. However, increasing evidence indicates that other techniques, such as the application of platelet-rich plasma, vacuum assisted closure, electrical stimulation, and hyperbaric oxygen therapy are effective and should be substituted for the older techniques. This review describes different standard and novel techniques that have been tested for eliminating pressure ulcers and discusses the relative efficacy of these techniques.
C1 Univ Puerto Rico, Inst Neurobiol, 201 Blvd Valle, San Juan, PR 00901 USA.
C3 University of Puerto Rico
RP Kuffler, DP (通讯作者)，Univ Puerto Rico, Inst Neurobiol, 201 Blvd Valle, San Juan, PR 00901 USA.
EM dkuffler@hotmail.com
RI /ABV-7119-2022
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NR 81
TC 15
Z9 16
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2015
VL 23
IS 3
BP 312
EP 317
DI 10.1111/wrr.12284
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CN8MC
UT WOS:000358693900003
PM 25801293
OA Bronze
DA 2026-07-24
ER

PT J
AU Kurihara, C
   Nishimura, T
   Kinoshita, O
   Kawata, M
   Hisagi, M
   Kyo, S
   Ono, M
AF Kurihara, Chitaru
   Nishimura, Takashi
   Kinoshita, Osamu
   Kawata, Mitsuhiro
   Hisagi, Motoyuki
   Kyo, Shunei
   Ono, Minoru
TI Successful treatment of mediastinitis after ventricular assist device
   implantation with rerouting of the outflow vascular prosthesis
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Ventricular assist device (VAD); Mediastinitis; Negative pressure wound
   therapy (NPWT); Rerouting
ID GUIDELINE; THERAPY
AB We report successful treatment of mediastinitis with rerouting of the outflow vascular prosthesis after bi-ventricular assist device (Bi-VAD) implantation. A 23 years-old male with fulminant myocarditis underwent VAD implantation. He required sternotomy three times. Mediastinitis developed after the third surgery, and negative pressure wound therapy (NPWT) with irrigation was applied. The infection was well controlled, but after 3 months of NPWT hemorrhage developed because of injury of the outflow vascular prosthesis in the anterior mediastinum. We rerouted the outflow vascular prosthesis to the descending aorta via the left thoracic cavity. After rerouting, artificial material was removed from the anterior mediastinum. The sternal wound healed completely after NPWT. Intractable mediastinitis after extra-corporeal VAD implantation may be treated with irrigation and NPWT, but there is a possibility of outflow graft injury. A sternal wound could be closed as a secondary healing process by rerouting the outflow vascular prosthesis.
C1 [Kurihara, Chitaru; Kinoshita, Osamu; Kawata, Mitsuhiro; Ono, Minoru] Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 1138655, Japan.
   [Nishimura, Takashi; Hisagi, Motoyuki; Kyo, Shunei] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo
RP Kurihara, C (通讯作者)，Univ Tokyo, Dept Cardiothorac Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM baby_star_1207@yahoo.co.jp; takashin-tky@umin.ac.jp
FU Grants-in-Aid for Scientific Research [21249073] Funding Source: KAKEN
CR Holman WL, 2004, J HEART LUNG TRANSPL, V23, P1359, DOI 10.1016/j.healun.2003.09.025
   Kawata M, 2005, J VASC SURG, V42, P573, DOI 10.1016/j.jvs.2004.05.025
   Kawata M, 2005, ARTIF ORGANS, V29, P820, DOI 10.1111/j.1525-1594.2005.00135.x
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NR 8
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PD JUN
PY 2011
VL 14
IS 2
BP 155
EP 158
DI 10.1007/s10047-010-0550-8
PG 4
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 778XU
UT WOS:000291743500010
PM 21286769
DA 2026-07-24
ER

PT J
AU Hisata, Y
   Hashizume, K
   Tanigawa, K
   Miura, T
   Odate, T
   Tasaki, Y
   Eishi, K
AF Hisata, Yoichi
   Hashizume, Koji
   Tanigawa, Kazuyoshi
   Miura, Takashi
   Odate, Tomohiro
   Tasaki, Yuichi
   Eishi, Kiyoyuki
TI Vacuum-assisted closure therapy for salvaging a methicillin-resistant
   Staphylococcus aureus-infected prosthetic graft
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infected prosthetic graft; methicillin-resistant Staphylococcus aureus;
   wound-closure techniques
ID PRESSURE WOUND THERAPY; MUSCLE FLAP COVERAGE; GROIN; MANAGEMENT;
   PROLIFERATION; PRESERVATION; EXPERIENCE
AB Infection of a vascular prosthesis after a bypass surgery is relatively rare. However, once developed, serious complications can occur, such as bleeding, sepsis, and organ ischemia, occasionally resulting in leg amputation or even death in some cases. The treatment of a vascular prosthesis infection involves the necessary removal of the infected graft; subsequently, an extra-anatomical bypass surgery is often considered. We herein report a case in which postoperative methicillin-resistant Staphylococcus aureus infection caused dehiscence of the femoral vessels and exposure of the graft vessel and anastomosed area. The infected tissue was surgically removed (debridement), and the patient's condition was successfully treated by the application of a nonadherent dressing and vacuum-assisted closure therapy combined with the bridging technique. Copyright (C) d2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Hisata, Yoichi; Hashizume, Koji; Tanigawa, Kazuyoshi; Miura, Takashi; Odate, Tomohiro; Tasaki, Yuichi; Eishi, Kiyoyuki] Nagasaki Univ Hosp, Div Cardiovasc Surg, Nagasaki 8528108, Japan.
C3 Nagasaki University
RP Hisata, Y (通讯作者)，Nagasaki Univ Hosp, Div Cardiovasc Surg, 1-7-1 Sakamoto, Nagasaki 8528108, Japan.
EM hisata.y@gmail.com
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   NEWINGTON DP, 1991, BRIT J SURG, V78, P617, DOI 10.1002/bjs.1800780530
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   Sumpio BE, 2008, VASCULAR, V16, P194, DOI 10.2310/6670.2008.00041
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
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NR 16
TC 1
Z9 3
U1 0
U2 0
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 46
EP 48
DI 10.1016/j.asjsur.2013.07.001
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800008
PM 23978424
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Sweigert, PJ
   Neelon, J
   Abood, G
   Marcotte, E
   Chand, B
AF Sweigert, Patrick J.
   Neelon, Jamie
   Abood, Gerard
   Marcotte, Eric
   Chand, Bipan
TI Endoscopic Management of a Complex Gastrojejunal and Pancreatic Leak
   Following Pancreaticoduodenectomy
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
DE pancreaticoduodenectomy; gastroenteric leak; endoscopic vacuum-assisted
   closure (EVAC); gastrojejunostomy; percutaneous endoscopic jejunostomy
   (PEJ)
ID VACUUM-ASSISTED CLOSURE; RESECTION; FISTULA
AB Background: Pancreaticoduodenectomy remains the mainstay of surgical treatment of malignant periampullary disorders. Postoperative morbidity rates are driven by postoperative pancreatic fistula. Although most can be managed conservatively or with percutaneous techniques, complex fistulas including gastroenteric leakage frequently require operative reexploration. Endoscopic therapies in this setting offer an opportunity to avoid invasive reoperation. Case Report: We present the case of a 67-year-old male individual who developed a complex intra-abdominal abscess after pancreaticoduodenectomy with confirmed pancreaticojejunal disruption, gastric staple line dehiscence, and enterocutaneous fistula. Five endoscopic sessions utilizing advanced techniques over a period of 60 days led to complete healing of the patient's external fistula, resolution of complex abdominal abscess, creation of functional communication between the gastric staple line disruption and the afferent jejunum, and return of normal gastrointestinal function. Baseline functional and dietary status was restored without gastrointestinal symptoms or necessity for supplemental tube feedings.
C1 [Sweigert, Patrick J.; Abood, Gerard; Marcotte, Eric; Chand, Bipan] Loyola Univ Med Ctr, Dept Surg, 2160 S First Ave, Maywood, IL 60153 USA.
   [Neelon, Jamie] Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA.
C3 Loyola University Chicago; Loyola University Chicago
RP Sweigert, PJ (通讯作者)，Loyola Univ Med Ctr, Dept Surg, 2160 S First Ave, Maywood, IL 60153 USA.
EM patrick.sweigert@lumc.edu
CR Bassi C, 2004, DIGEST SURG, V21, P54, DOI 10.1159/000075943
   Birkmeyer JD, 2007, ANN SURG, V245, P777, DOI 10.1097/01.sla.0000252402.33814.dd
   CULLEN JJ, 1994, AM J SURG, V168, P295, DOI 10.1016/S0002-9610(05)80151-5
   Eisendrath P, 2007, ENDOSCOPY, V39, P625, DOI 10.1055/s-2007-966533
   Eshuis WJ, 2014, SURGERY, V156, P75, DOI 10.1016/j.surg.2014.03.044
   García EBG, 2009, LANCET ONCOL, V10, P727, DOI 10.1016/S1470-2045(09)70167-6
   LILLEMOE KD, 1995, ANN SURG, V221, P133, DOI 10.1097/00000658-199502000-00003
   Liu YN, 2014, WORLD J SURG ONCOL, V12, DOI 10.1186/1477-7819-12-240
   Nguyen NT, 2011, J GASTROINTEST SURG, V15, P1952, DOI 10.1007/s11605-011-1658-8
   Pfau PR, 2000, GASTROINTEST ENDOSC, V52, P55, DOI 10.1067/mge.2000.106687
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Yimcharoen P, 2011, SURG OBES RELAT DIS, V7, P628, DOI 10.1016/j.soard.2011.03.017
NR 13
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD JUN
PY 2020
VL 30
IS 3
BP 218
EP 220
DI 10.1097/SLE.0000000000000733
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MB9UL
UT WOS:000542942900005
PM 31714479
DA 2026-07-24
ER

PT J
AU Gunn, LA
   Follmar, KE
   Wong, MS
   Lettieri, SC
   Levin, LS
   Erdmann, D
AF Gunn, Laura A.
   Follmar, Keith E.
   Wong, Miehael S.
   Lettieri, Salvatore C.
   Levin, L. Seott
   Erdmann, Detlev
TI Management of enterocutaneous fistulas using negative-pressure dressings
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE enterocutaneous fistula; VAC; negative-pressure dressing;
   vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; PARENTERAL-NUTRITION; SMALL-INTESTINE;
   GASTROINTESTINAL FISTULAS; CONSERVATIVE TREATMENT; SOMATOSTATIN; SYSTEM;
   TRIAL; COMBINATION; WOUNDS
AB Fifteen patients with enterocutaneous fistulas (ECFs) not amenable to surgical treatment were treated with negative-pressure dressings over the abdominal wound and ECF. Closure of the ECF and time to closure were examined. In 11 patients who had no visible intestinal mucosa on examination, the closure rate was 100%, with a mean time to closure of 14 days. In 4 patients who did have grossly visible intestinal mucosa, no closure occurred. This represents an overall closure rate of 73%. Fistula output rate did not have a significant effect on outcome. These results confirm the efficacy of negative-pressure dressings in the closure of ECFs. Presence or absence of visible intestinal mucosa is the single most important clinical factor when considering the use of a negative-pressure dressing in the management of a patient with ECF.
C1 Duke Univ, Ctr Med, Div Plast Reconstruct Maxillofacial & Oral Surg, Dept Surg, Durham, NC 27710 USA.
C3 Duke University
RP Erdmann, D (通讯作者)，Duke Univ, Ctr Med, Div Plast Reconstruct Maxillofacial & Oral Surg, Dept Surg, POB 3181, Durham, NC 27710 USA.
EM Detlev.Erdmann@duke.edu
OI Wong, Michael/0009-0001-0628-605X
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Berry SM, 1997, MAINGOTS ABDOMINAL O, P581
   Chamberlain RS, 1998, AM SURGEON, V64, P1204
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NR 32
TC 27
Z9 31
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2006
VL 57
IS 6
BP 621
EP 625
DI 10.1097/01.sap.0000228966.13979.1c
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 109OV
UT WOS:000242318800006
PM 17122546
DA 2026-07-24
ER

PT J
AU Fuller, M
   Luff, R
   Van den Boom, M
AF Fuller, Matthew
   Luff, Robin
   Van den Boom, Monique
TI A novel approach to wound management and prosthetic use with concurrent
   vacuum-assisted closure therapy
SO PROSTHETICS AND ORTHOTICS INTERNATIONAL
LA English
DT Article
DE Prosthetic design; rehabilitation of amputees; wound management
ID AMPUTATION; AMPUTEES
AB Background and Aim: Stump healing is critical to post amputation management. When healing is not optimal, immobility is prolonged and patients risk hospital acquired deconditioning. Two clinical cases with unhealed trans-femoral stump wounds are described. Vacuum assisted closure (VAC) dressing with concurrent prosthetic utilisation was undertaken successfully in both cases.
   Technique: Fitting of the prosthetic socket included space for VAC dressing with modifications to allow the suction piping to exit the prosthesis. With VAC application, timely rehabilitation and mobility was enabled despite incomplete wound healing.
   Discussion: The two clinical cases described made excellent progress. Discharge home was expedited with the provision of portable VAC pumps. Wounds healed fully without infection. Both patients were able to mobilise sooner than if they had to wait for complete wound closure and, importantly, the consequences of prolonged immobility were minimised. No extra costs were incurred using this novel therapy.
C1 [Fuller, Matthew] Bowley Close Rehabil Ctr, Prosthet Physiotherapy Dept, Southwark PCT, London, England.
   [Van den Boom, Monique] Southwark PCT Rehabil Ctr, Prosthet Dept, London, England.
RP Fuller, M (通讯作者)，Guys & St Thomas NHS Fdn Trust, Physiothatrpy Dept, St Thomas Hosp, Westminster Bridge Rd, London SE1 7EH, England.
EM matthew.fuller@gstt.nhs.uk
CR Asano M, 2008, PROSTHET ORTHOT INT, V32, P231, DOI 10.1080/03093640802024955
   de Morton NA, 2007, CLIN REHABIL, V21, P3, DOI 10.1177/0269215506071313
   Harker J., 2006, World Wide Wounds
   Kulkarni J, 2006, Int J Surg, V4, P217
   MIKLOS C, 2007, TECH FOOT ANKLE SURG, V6, P166
   Nawijn SE, 2005, PROSTHET ORTHOT INT, V29, P13, DOI 10.1080/17461550500066832
   Ryall NH, 2003, DISABIL REHABIL, V25, P833, DOI 10.1080/0963828021000056460
   Thomas Steve., 2001, World Wide Wounds
   van Velzen AD, 2005, PROSTHET ORTHOT INT, V29, P3, DOI 10.1080/17461550500069588
   VanRoss ER, 2009, ARCH PHYS MED REHAB, V90, P610, DOI 10.1016/j.apmr.2008.10.026
NR 10
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0309-3646
EI 1746-1553
J9 PROSTHET ORTHOT INT
JI Prosthet. Orthot. Int.
PD JUN
PY 2011
VL 35
IS 2
BP 246
EP 249
DI 10.1177/0309364610397085
PG 4
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA 822GV
UT WOS:000295032900015
PM 21527397
DA 2026-07-24
ER

PT J
AU Huston, TL
   Grant, RT
AF Huston, Tara L.
   Grant, Robert T.
TI Abdominal wall gossypiboma
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum assisted closure device; Abdominoplasty; Bariatric body
   contouring; Gossypiboma
AB A 71-year-old woman, one year following a fleur-de-lis abdominoplasty and incisional hernia repair, presented with two chronic, draining peri-umbilical sinuses. Her immediate postoperative course was complicated by a superficial surgical site infection with central skin breakdown that was treated with vacuum assisted closure (VAC). After the wound had closed completely, two midline sinus tracts developed. A CT scan demonstrated an 8 x 3 x 1.6 cm thick-walled collection along the anterior abdominal wall containing numerous air bubbles. Surgical debridement revealed a cavity containing an 8 x 3 x 1.6 cm block of well incorporated VAC foam. With the increasing clinical use of VAC wound therapy, this image serves as an important reminder to include gossypiboma in the differential diagnosis for patients with chronic wound problems who have previously received VAC treatment. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Huston, Tara L.; Grant, Robert T.] New York Presbyterian Hosp, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital
RP Huston, TL (通讯作者)，New York Presbyterian Hosp, 525 E 68th St,K707, New York, NY 10065 USA.
EM taa9002@nyp.org
CR Gawande AA, 2003, NEW ENGL J MED, V348, P229, DOI 10.1056/NEJMsa021721
   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
NR 2
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2010
VL 63
IS 5
BP E463
EP E464
DI 10.1016/j.bjps.2009.07.034
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 577CW
UT WOS:000276199700033
PM 19683975
DA 2026-07-24
ER

PT J
AU Lohsiriwat, V
AF Lohsiriwat, Varut
TI Persistent perineal sinus: Incidence, pathogenesis, risk factors, and
   management
SO SURGERY TODAY
LA English
DT Review
DE Pathogenesis; Persistent perineal sinus; Risk factors; Treatment
ID INFLAMMATORY-BOWEL-DISEASE; ABDOMINOPERINEAL RECTAL EXCISION; ABDOMINIS
   MYOCUTANEOUS FLAP; PERIANAL CROHNS-DISEASE; VACUUM-ASSISTED CLOSURE;
   RESTORATIVE PROCTOCOLECTOMY; PREOPERATIVE RADIOTHERAPY; WOUND
   COMPLICATIONS; CONTROLLED TRIAL; POUCH EXCISION
AB This review discusses the incidence, pathogenesis, risk factors, diagnosis, and therapeutic options for persistent perineal sinus (PPS), defined as a perineal wound that remains unhealed more than 6 months after surgery. The incidence of PPS after surgery for inflammatory bowel disease (IBD) ranges from 3% to 70% and after abdominoperineal resection (APR) for low rectal cancer, it can be up to 30%. These unhealed wounds are frequently related to perioperative pelvic or perineal sepsis. Crohn's disease (CD) and neoadjuvant radiation therapy are also important risk factors. The management of PPS is based on an understanding of pathogenesis and clinical grounds. The advantages and disadvantages of the current therapeutic approaches, including the topical administration of various drugs, vacuum-assisted closure, and perineal reconstruction with a muscle flap or a myocutaneous flap are also discussed.
C1 Mahidol Univ, Dept Surg, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand.
C3 Mahidol University
RP Lohsiriwat, V (通讯作者)，Mahidol Univ, Dept Surg, Fac Med, Siriraj Hosp, Prannok Rd, Bangkok 10700, Thailand.
RI Lohsiriwat, Varut/AAD-7143-2019
OI Lohsiriwat, Varut/0000-0002-2252-9509
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NR 48
TC 24
Z9 31
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
J9 SURG TODAY
JI Surg. Today
PD MAR
PY 2009
VL 39
IS 3
BP 189
EP 193
DI 10.1007/s00595-008-3846-z
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 418GI
UT WOS:000264136300002
PM 19280276
DA 2026-07-24
ER

PT J
AU Lejay, A
   Creton, O
   Thaveau, F
   Bajcz, C
   Stephan, D
   Kretz, JG
   Chakfé, N
AF Lejay, A.
   Creton, O.
   Thaveau, F.
   Bajcz, C.
   Stephan, D.
   Kretz, J. -G.
   Chakfe, N.
TI Current clinical applications of vacuum-assisted closure (VAC) in
   vascular surgery
SO JOURNAL DES MALADIES VASCULAIRES
LA French
DT Article
ID WOUND THERAPY; ISCHEMIA; TRIAL
AB The aim of the study was to evaluate the efficacy of vacuum-assisted closure (VAC) in vascular patients presenting limb ulcers or non heated amputations. The efficacy of the VAC was studied in terms of heating, walking distance, and autonomy of life. This retrospective study included 14 patients, 11 men and three women, who were treated by a VAC therapy between December 2003 and February 2007. Two patients presented critical ischemia with limb ulcers and 12 patients non heated amputations despite previous revascularisation. Vascular reconstruction was performed in all cases before the VAC therapy. The rate of wound heating with VAC therapy was 87%. After wound heating, 92% of patients were walking and 62% of them were independent. In conclusion, VAC therapy may be a useful toot to accelerate heating of lower-timb wounds or non healing wounds secondary to amputation, allowing a faster recovery with a good level of autonomy. (c) 2008 Elsevier Masson SAS.
C1 [Lejay, A.; Creton, O.; Thaveau, F.; Bajcz, C.; Kretz, J. -G.; Chakfe, N.] Ctr Hosp Reg Univ, Serv Chirurg Vasc, F-67091 Strasbourg, France.
   [Stephan, D.] Ctr Hosp Reg Univ, Serv Malad Vasc, F-67091 Strasbourg, France.
C3 CHU Strasbourg; CHU Strasbourg
RP Chakfé, N (通讯作者)，Ctr Hosp Reg Univ, Serv Chirurg Vasc, 1 Pl Hop,BP 426, F-67091 Strasbourg, France.
EM nabil.chakfe@chru-strasbourg.fr
RI Stephan, Dominique/PNF-0972-2026
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 20
TC 5
Z9 6
U1 0
U2 4
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0398-0499
J9 J MAL VASCUL
JI J. Mal. Vasc.
PD DEC
PY 2008
VL 33
IS 4-5
BP 196
EP 201
DI 10.1016/j.jmv.2008.08.002
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 390YR
UT WOS:000262200100002
PM 19019600
DA 2026-07-24
ER

PT J
AU Alateeq, MF
   Park, SW
   Ahn, JY
   Lee, YS
AF Alateeq, Mohammed F.
   Park, Sang-Wook
   Ahn, Ji Yong
   Lee, Yoon Se
TI Endoscopic Vacuum-Assisted Closure for Radiation-Induced
   Laryngotracheoesophageal Fistula
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Negative suction; radiation therapy; radionecrosis; tracheoesophageal
   fistula; vacuum
AB Radionecrosis can occur in any irradiated area of the head and neck, and when it involves the laryngotracheal region, it may lead to a laryngoesophageal fistula, causing dysphagia, aspiration, and life-threatening bleeding. A 45-year-old male with renal cell carcinoma (RCC) was referred due to prolonged dysphagia, recurrent aspiration, and hemoptysis after radiation therapy for a metastatic cervical spine lesion. Laryngoscopy and CT scan revealed destruction of the posterior cricoid cartilage and the membranous trachea, with a fistula formed between the laryngotrachea and pharynx. Due to extensive necrosis, wide debridement with reconstruction was initially considered. However, as the patient was receiving palliative treatment for multiple metastatic diseases, endoluminal vacuum-assisted closure (EVAC) was applied instead. EVAC, combined with antibiotics and nutritional support, successfully closed the fistula, allowing the patient to resume a normal diet. This case demonstrates that EVAC is a feasible method for treating laryngotracheal fistula while preserving laryngeal function with minimal complications.
C1 [Alateeq, Mohammed F.] Univ Hail, Dept Otolaryngol, Hail, Saudi Arabia.
   [Alateeq, Mohammed F.; Park, Sang-Wook; Lee, Yoon Se] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   [Ahn, Ji Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea.
C3 University Ha'il; University of Ulsan; Asan Medical Center; University
   of Ulsan; Asan Medical Center
RP Lee, YS (通讯作者)，Asan Med Ctr, 88 Olymp Ro,43 Gil, Seoul 05505, South Korea.
EM waw1413@hotmail.com; willjeffsw@gmail.com; ji110@hanmail.net;
   manseilee@gmail.com
RI Ahn, Ji Yong/AGO-1695-2022; alateeq, mohammed/KIC-8064-2024
OI Ahn, Ji Yong/0000-0002-0030-3744; alateeq, mohammed/0000-0002-7162-641X
FU Asan Institute for Life Sciences [2022IP0085]; Elimination of Cancer
   Project Fund from Asan Cancer Institute of Asan Medical Center, Seoul,
   Korea
FX This study was also supported by a grant (2022IP0085) from the Asan
   Institute for Life Sciences and the Elimination of Cancer Project Fund
   from Asan Cancer Institute of Asan Medical Center, Seoul, Korea.
CR Abugroun Ashraf, 2017, World J Oncol, V8, P171, DOI [10.14740/wjon1063w, 10.14740/wjon1063w]
   Ahn SJ, 2005, INT J RADIAT ONCOL, V61, P335, DOI 10.1016/j.ijrobp.2004.06.014
   Delanian S, 2004, RADIOTHER ONCOL, V73, P119, DOI 10.1016/j.radonc.2004.08.021
   Levin EG, 2025, HEAD NECK-J SCI SPEC, V47, P300, DOI 10.1002/hed.27919
   MARX RE, 1983, J ORAL MAXIL SURG, V41, P351, DOI 10.1016/S0278-2391(83)80005-6
   Möschler O, 2015, ENDOSC INT OPEN, V3, pE554, DOI 10.1055/s-0034-1392568
   Ramai D, 2019, ANN GASTROENTEROL, V32, P24, DOI 10.20524/aog.2018.0321
   Vohra I, 2025, CLIN ENDOSC, V58, P53
   Yang YH, 2013, J PLAST RECONSTR AES, V66, pE209, DOI 10.1016/j.bjps.2013.03.006
   Zeng A, 2024, EUR J CARDIO-THORAC, V65, DOI 10.1093/ejcts/ezae047
NR 10
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD OCT
PY 2025
VL 36
IS 7
BP e945
EP e947
DI 10.1097/SCS.0000000000011653
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8JJ5B
UT WOS:001590070700010
PM 40608776
DA 2026-07-24
ER

PT J
AU Stoeckel, WT
   David, L
   Levine, EA
   Argenta, AE
   Perrier, ND
AF Stoeckel, William T.
   David, Lisa
   Levine, Edward A.
   Argenta, Anne E.
   Perrier, Nancy D.
TI Vacuum-assisted closure for the treatment of complex breast wounds
SO BREAST
LA English
DT Article
DE breast; surgery; wound; vacuum
AB Complex breast wounds are a constant problem for surgeons. Wound vacuum-assisted closure therapy (VAC) has been shown to be effective for a variety of complex wounds. Our goal was to evaluate our experience with the (VAC) device in the treatment of open breast wounds.
   We retrospectively identified 18 patients with complex breast wounds treated with the VAC. We analyzed the data regarding the nature and management of these wounds using the VAC device.
   Fifteen of 18 patients were treated effectively using the VAC. Two patients required muscle flap coverage. One patient had the VAC dressing discontinued secondary to a denial by an insurance company for VAC in the home setting.
   VAC therapy is an effective treatment for complex wounds. Specifically, our experience shows it to be effective in the treatment of complex breast wounds. Utilization of VAC therapy should be considered for the management of these challenging wounds. (C) 2005 Published by Elsevier Ltd.
C1 [Stoeckel, William T.; David, Lisa; Levine, Edward A.; Argenta, Anne E.; Perrier, Nancy D.] Wake Forest Univ, Bowman Gray Sch Med, Surg Oncol Serv, Baptist Med Ctr, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP David, L (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Surg Oncol Serv, Baptist Med Ctr, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM ldavid@wfubmc.edu
RI Perrier, Nancy/T-7474-2019
CR Baynham S A, 1999, Ostomy Wound Manage, V45, P28
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Bland K I:., 1998, The Breast: comprehension management of benign and malignant diseases, P75
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Joseph E, 2000, WOUNDS, V12, P60
   LACEY J, 2002, ENV MAL MUTAGEN, V8, P82
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Stonerock CE, 2003, AM SURGEON, V69, P1030
NR 11
TC 19
Z9 20
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0960-9776
J9 BREAST
JI Breast
PD OCT
PY 2006
VL 15
IS 5
BP 610
EP 613
DI 10.1016/j.breast.2005.11.006
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA V44PR
UT WOS:000203015100008
PM 16443363
DA 2026-07-24
ER

PT J
AU Halama, D
   Hemprich, A
   Frerich, B
AF Halama, D
   Hemprich, A
   Frerich, B
TI Intraoral application of vacuum-assisted closure in the treatment of an
   extended mandibular keratocyst
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE keratocyst; Vacuum-Assisted Closure; woundhealing
ID LARGE ODONTOGENIC KERATOCYSTS; MANAGEMENT
AB In extended cysts of the jaw bone particular demands are made in terms of wound closure, especially if an intraoral surgical approach is chosen. A tight closure is even more important if the bony defect has been filled with an alloplastic material or autologous cancellous bone.
   In our case a keratocyst of the left mandibular angle and ascending ramus was treated.
   After enucleation of the cyst and grafting with autologous cancellous bone the graft was lost following a wound breakdown. Subsequently a system was developed to apply intraoral V.A.C.(R)-therapy. This led to a safe separation of the cystic defect and the oral cavity and a conditioning of the wound ground. A grafting with an alloplastic material was carried out successfully. with this method the length of treatment could be reduced by several months compared to a conventional therapy with an obturator.
C1 Univ Klinikum Leipzig, Klin & Poliklin Mund Kiefer & Plast Gesicht, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Halama, D (通讯作者)，Univ Klinikum Leipzig, Klin & Poliklin Mund Kiefer & Plast Gesicht, Nurnberger Str 57, D-04103 Leipzig, Germany.
EM dirk.halama@medizin.uni-leipzig.de
RI ; Hemprich, Alexander/JXL-9631-2024
OI Frerich, Bernhard/0000-0001-6707-2429; 
CR [Anonymous], 1956, TANDL GEBLADET, V60, P963
   Bauer P, 1998, Handchir Mikrochir Plast Chir, V30, P20
   CROWLEY TE, 1992, J ORAL MAXIL SURG, V50, P22, DOI 10.1016/0278-2391(92)90187-5
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   SCHWENZER N, 2000, ZAHN MUND KIEFER HEI, V3, P96
   WILLIAMS TP, 1994, J ORAL MAXIL SURG, V52, P964, DOI 10.1016/S0278-2391(10)80081-3
NR 11
TC 4
Z9 10
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S53
EP S56
DI 10.1055/s-2004-822669
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600017
PM 15168287
DA 2026-07-24
ER

PT J
AU Wee, IJY
   Mak, M
   O'Donnell, G
   Tan, J
   Chong, TT
   Tang, TY
AF Wee, Ian J. Y.
   Mak, Manfred
   O'Donnell, Gavin
   Tan, Jerilyn
   Chong, Tze T.
   Tang, Tjun Y.
TI The smart negative pressure (SNaP) wound care system: A case series from
   Singapore
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE outcome; SNaP; vacuum-assisted closure; wound
ID VACUUM-ASSISTED CLOSURE; LEG ULCERS; THERAPY; MULTICENTER
AB The Smart Negative Pressure (SNaP) wound care system is a novel device that is single-patient use, ultra-portable, and light weight and does not rely on battery or need recharging. A systematic search was performed on major databases to identify relevant articles including case reports, retrospective case series, and randomised controlled trials. Ten studies were identified, showing that the SNaP wound care system is an effective tool in treating small-sized wounds and may serve as an alternative to current electrically powered modalities. Furthermore, the system's small size and convenience leads to greater patient satisfaction and improves quality of life. Finally, we report our initial positive experiences with two cases in our institution. Although the evidence thus far has been encouraging, and patient satisfaction is higher than other wound care systems, further evidence is required to determine its superiority over current systems in terms of wound-healing outcomes.
C1 [Wee, Ian J. Y.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Mak, Manfred; O'Donnell, Gavin; Tan, Jerilyn] Singapore Gen Hosp, Dept Podiatry, Singapore, Singapore.
   [Chong, Tze T.; Tang, Tjun Y.] Singapore Gen Hosp, Dept Vasc Surg, Level 5,20 Coll Rd, Singapore 169856, Singapore.
C3 National University of Singapore; Singapore General Hospital; Singapore
   General Hospital
RP Tang, TY (通讯作者)，Singapore Gen Hosp, Dept Vasc Surg, Level 5,20 Coll Rd, Singapore 169856, Singapore.
EM tang.tjun.yip@singhealth.com.sg
RI ; Mak, Manfred/LJK-1821-2024
OI Wee, Ian/0000-0001-8778-1943; 
CR Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Awad T, 2013, J WOUND CARE, V22, P162, DOI 10.12968/jowc.2013.22.3.162
   Awad TBM, 2012, WOUNDS INT, V3, P44
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bradbury S, 2015, ADV WOUND CARE, V4, P346, DOI 10.1089/wound.2014.0596
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   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
   Marston WA, 2015, ADV WOUND CARE, V4, P75, DOI 10.1089/wound.2014.0575
   Martinengo L, 2019, ANN EPIDEMIOL, V29, P8, DOI 10.1016/j.annepidem.2018.10.005
   Neiderer K, 2012, OSTOMY WOUND MANAG, V58, P44
   Sen CK, 2009, WOUND REPAIR REGEN, V17, P763, DOI 10.1111/j.1524-475X.2009.00543.x
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 17
TC 5
Z9 7
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2019
VL 16
IS 4
BP 891
EP 896
DI 10.1111/iwj.13114
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IK6AN
UT WOS:000476667700003
PM 30900370
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Petca, A
   Negoita, S
   Petca, RC
   Borislavschi, A
   Calo, IG
   Popescu, VG
   Sinescu, RD
AF Petca, Aida
   Negoita, Silvius
   Petca, Razvan-Cosmin
   Borislavschi, Andreea
   Calo, Ioana Gabriela
   Popescu, Valentina Gabriela
   Sinescu, Ruxandra Diana
TI BACTERIAL PATHOGENS ISOLATED FROM SURGICAL SITE INFECTIONS AND THEIR
   ANTIBIOTIC SUSCEPTIBILITY
SO FARMACIA
LA English
DT Article
DE pathogens; MDR bacterial pathogens; surgical site infections;
   vacuum-assisted closure; hospital-acquired infections
ID ANTIMICROBIAL SUSCEPTIBILITY; RESISTANCE; SURVEILLANCE; GUIDELINES
AB The increased reservoir of pathogenic bacteria sheltered in hospitals is the cause of various types of nosocomial infections and represents one of the major health problems. Surgical site infections (SSIs) count for 14 - 16% of all hospital-acquired infections (HAI) and represent the 3rd most occurring nosocomial infections and the 3rd most expensive HAI. We present a germ pattern (on 92 strains), located in post-operative dehiscence sites - treated with vacuum-assisted closure, in failed per secundam suture. The most common pathogens were E. coli - 18.47% (76.47% multi-drug resistant - MDR), Pseudomonas aeruginosa - 16.30% (33.33% MDR) and Enterococcus faecalis - 15.21%. Acinetobacter baumannii (100%) and Klebsiella pneumoniae (88.88%) also showed multi-drug resistance. Gentamicin, amikacin and carbapenems (> 50% sensibility) are eligible for treating SSIs, whereas cephalosporins have a higher resistance rate (> 50%). Knowledge of resistance patterns in SSIs is recommendable to ensure proper empirical treatment.
C1 [Petca, Aida; Borislavschi, Andreea; Calo, Ioana Gabriela] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Obstet & Gynaecol, Bucharest, Romania.
   [Negoita, Silvius] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Anaesthesiol & Crit Care, Bucharest, Romania.
   [Petca, Razvan-Cosmin] Carol Davila Univ Med & Pharm, Prof Dr Th Burghele Clin Hosp, Dept Urol, Bucharest, Romania.
   [Popescu, Valentina Gabriela] Elias Univ Emergency Hosp, Dept Vasc Surg, Bucharest, Romania.
   [Sinescu, Ruxandra Diana] Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy
RP Borislavschi, A (通讯作者)，Carol Davila Univ Med & Pharm, Elias Univ Emergency Hosp, Dept Obstet & Gynaecol, Bucharest, Romania.
EM andreea.borislavschi@gmail.com
RI Petca, Aida/AAM-9912-2020; /ABD-2479-2020; Borislavschi,
   Andreea/HMD-4904-2023; Visan, Ioana Gabriela/LWI-3374-2024; NEGOITA,
   SILVIUS/AAG-2433-2021; Petca, Răzvan-Cosmin/AAH-2462-2020
OI Visan, Ioana Gabriela/0000-0001-6134-0728; 
FU CNCSIS-UEFISCDI, Postdoctoral Fellowship Programme PN-II-Human Resources
   [3/28.07.2010, PD 149/2010]
FX This work was financially supported by CNCSIS-UEFISCDI, Postdoctoral
   Fellowship Programme PN-II-Human Resources, project number 3/28.07.2010,
   code PD 149/2010.
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   Petca RC, 2019, FARMACIA, V67, P994, DOI 10.31925/farmacia.2019.6.9
   Purba AKR, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00776
   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
   Sharma D, 2019, ANTIMICROB RESIST IN, V8, DOI 10.1186/s13756-019-0533-3
   Sikka R, 2012, INDIAN J CLIN PRACTI, V22, P519
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   World Union of Wound Healing Societies, 2018, Surgical wound dehiscence: improving prevention and outcomes
NR 45
TC 8
Z9 9
U1 3
U2 11
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD JUL-AUG
PY 2021
VL 69
IS 4
BP 741
EP 748
DI 10.31925/farmacia.2021.4.15
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UD2JT
UT WOS:000687039600015
OA gold
DA 2026-07-24
ER

PT J
AU Emohare, O
   Kowal-Vern, A
   Wiley, D
   Latenser, BA
AF Emohare, O
   Kowal-Vern, A
   Wiley, D
   Latenser, BA
TI Vacuum-assisted closure use in calciphylaxis
SO JOURNAL OF BURN CARE & REHABILITATION
LA English
DT Article
ID PARATHYROIDECTOMY; SURVIVAL; SYSTEM
AB Calciphylaxis-induced chronic wounds are difficult to heal. The value of vacuum-assisted closure (VAC) was assessed in two patients with calciphylaxis. Two middle-aged females with type 2 diabetes were transferred to the burn unit with a clinical diagnosis of necrotizing fasciitis, although the pathologic diagnosis was calciphylaxis. With extensive debridement, antibiotics, and meticulous wound care, one patient had progressive necrosis of her skin from 18 to 48% TBSA, whereas the other progressed from 5 to 10% TBSA only. The patient with the smaller chronic wound healed well and left the hospital at 72 days after admission. Although there was some success with the use of VAC, the patient with the extensive progressive wounds developed a fungal wound infection that did not respond to treatment; she died 78 days after initiation of burn center treatment. Some disadvantages to the usefulness would be extensive contiguous wounds and the lack of an intact skin surface. The VAC system was of value in healing wounds resulting from calciphylaxis.
C1 Cook Cty Hosp, Sumner L Koch Burn Ctr, Dept Trauma, Chicago, IL 60612 USA.
   Univ London Imperial Coll Sci & Technol, Fac Med, London, England.
C3 John H Stroger Junior Hospital Cook County; Imperial College London
RP Latenser, BA (通讯作者)，Cook Cty Hosp, Sumner L Koch Burn Ctr, Dept Trauma, 1901 W Harrison St, Chicago, IL 60612 USA.
CR Essary LR, 2000, AM J CLIN PATHOL, V113, P280, DOI 10.1309/AGLF-X21H-Y37W-50KL
   Faucher LD, 2001, AM J SURG, V182, P563, DOI 10.1016/S0002-9610(01)00785-1
   Fine A, 2002, KIDNEY INT, V61, P2210, DOI 10.1046/j.1523-1755.2002.00375.x
   FISCHER AH, 1995, HUM PATHOL, V26, P1055, DOI 10.1016/0046-8177(95)90266-X
   Girotto JA, 2001, SURGERY, V130, P645, DOI 10.1067/msy.2001.117101
   Kirby JP, 2002, J TRAUMA, V53, P117, DOI 10.1097/00005373-200207000-00024
   Kriskovich MD, 2000, LARYNGOSCOPE, V110, P603, DOI 10.1097/00005537-200004000-00012
   Majeski J, 1997, SOUTHERN MED J, V90, P1065, DOI 10.1097/00007611-199711000-00001
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   SELYE H, 1962, ENDOCRINOLOGY, V71, P554, DOI 10.1210/endo-71-4-554
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NR 14
TC 8
Z9 16
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0273-8481
J9 J BURN CARE REHABIL
JI J. Burn Care Rehabil.
PD MAR-APR
PY 2004
VL 25
IS 2
BP 161
EP 164
DI 10.1097/01.BCR.0000111764.67904.CD
PG 4
WC Emergency Medicine; Rehabilitation; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Rehabilitation; Surgery
GA 800QT
UT WOS:000220043500002
PM 15091142
DA 2026-07-24
ER

PT J
AU Joseph, E
   Hamori, CA
   Bergman, S
   Roaf, E
   Swann, NF
   Anastasi, GW
AF Joseph, E
   Hamori, CA
   Bergman, S
   Roaf, E
   Swann, NF
   Anastasi, GW
TI A prospective randomized trial of vacuum-assisted closure versus
   standard therapy of chronic nonhealing wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID DRESSINGS
AB Chronic, open, nonhealing wounds pose a continual challenge in medicine. Our objective was to evaluate vacuum-assisted closure (VAC)* therapy's ability to improve the healing rare of chronic wounds compared to the traditional saline-wet-to-moist (WM) dressings. Twenty-four patients with 36 chronic, nonhealing wounds were enrolled in the study after obtaining proper consent. Subjects were randomized to the VAC group or the control group. Biopsies and wound measurements were obtained by blinded independent wound evaluators. The most significant difference was the change in depth of 66 percent for VAC compared to 20 percent for WM (p<.00001). Histologically, the groups exhibited different characteristics. In the WM group, 81 percent (n=13) displayed inflammation and fibrosis. The chief characteristic of the VAC group was granulation tissue formation in 64 percent (n=9) of those wounds. The VAC system should be used to obtain wound closure, especially of chronic nonhealing wounds with great depth, rather than the traditional saline WM dressings.
C1 Med Coll Ohio, Dept Plast Surg, Toledo, OH 43615 USA.
RP Joseph, E (通讯作者)，Med Coll Ohio, Dept Plast Surg, 626 Pine Valley Lane,203, Toledo, OH 43615 USA.
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NR 13
TC 251
Z9 312
U1 0
U2 14
PU HEALTH MANAGEMENT PUBLICATIONSINC
PI WAYNE
PA 950 WEST VALLEY RD, STE 2800, WAYNE, PA 19087 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY-JUN
PY 2000
VL 12
IS 3
BP 60
EP 67
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 325LN
UT WOS:000087677200006
DA 2026-07-24
ER

PT J
AU Zanus, G
   Boetto, R
   D'Amico, F
   Gringeri, E
   Vitale, A
   Carraro, A
   Bassi, D
   Scopelliti, M
   Bonsignore, P
   Burra, P
   Angeli, P
   Feltracco, P
   Cillo, U
AF Zanus, Giacomo
   Boetto, Riccardo
   D'Amico, Francesco
   Gringeri, Enrico
   Vitale, Alessandro
   Carraro, Amedeo
   Bassi, Domenico
   Scopelliti, Michele
   Bonsignore, Pasquale
   Burra, Patrizia
   Angeli, Paolo
   Feltracco, Paolo
   Cillo, Umberto
TI A novel approach to severe acute pancreatitis in sequential liver-kidney
   transplantation: the first report on the application of VAC therapy
SO TRANSPLANT INTERNATIONAL
LA English
DT Article
DE abdominal sepsis; complications; kidney transplantation; liver
   transplantation; pancreatitis; vacuum-assisted closure therapy
ID ASSISTED CLOSURE; BILIARY STRICTURES; SEVERE PERITONITIS; MANAGEMENT;
   RECIPIENTS; FAILURE; WOUNDS
AB P>This work is the first report of vacuum-assisted closure (VAC) therapy applied as a life-saving surgical treatment for severe acute pancreatitis occurring in a sequential liver- and kidney-transplanted patient who had percutaneous biliary drainage for obstructive "late-onset" jaundice. Surgical exploration with necrosectomy and sequential laparotomies was performed because of increasing intra-abdominal pressure with hemodynamic instability and intra-abdominal multidrug-resistant sepsis, with increasingly difficult abdominal closure. Repeated laparotomies with VAC therapy (applying a continuous negative abdominal pressure) enabled a progressive, successful abdominal decompression, with the clearance of infection and definitive abdominal wound closure. The application of a negative pressure is a novel approach to severe abdominal sepsis and laparostomy management with a view to preventing compartment syndrome and fatal sepsis, and it can lead to complete abdominal wound closure.
C1 [Zanus, Giacomo; Boetto, Riccardo; D'Amico, Francesco; Gringeri, Enrico; Vitale, Alessandro; Carraro, Amedeo; Bassi, Domenico; Scopelliti, Michele; Bonsignore, Pasquale; Cillo, Umberto] Azienda Univ Padova, Hepatobiliary Surg & Liver Transplant Unit, I-35139 Padua, Italy.
   [Feltracco, Paolo] ICU, Padua, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova
RP Boetto, R (通讯作者)，Azienda Univ Padova, Hepatobiliary Surg & Liver Transplant Unit, Via Concariola N 2, I-35139 Padua, Italy.
EM rboetto@hotmail.com
RI D'Amico, Francesco/AFL-3751-2022; Carraro, Amedeo/AAB-9001-2019;
   GRINGERI, ENRICO/AAB-9315-2019; Cillo, Umberto/AAC-2591-2019;
   Bonsignore, Pasquale/I-7898-2018; Vitale, Alessandro/AAA-9182-2021;
   Burra, Patrizia/AAB-2448-2019; Angeli, Paolo/A-9759-2015; Zanus,
   Giacomo/AIB-1093-2022
OI D'Amico, Francesco/0000-0001-6915-9755; Carraro,
   Amedeo/0000-0001-6449-4597; Scopelliti, Michele/0000-0001-9965-1281;
   GRINGERI, ENRICO/0000-0002-3459-7306; Cillo,
   Umberto/0000-0002-2310-0245; Bonsignore, Pasquale/0000-0002-3118-5453;
   Vitale, Alessandro/0000-0002-4548-8308; Burra,
   Patrizia/0000-0002-8791-191X; 
CR Al-Bahrani A Z, 2006, HPB (Oxford), V8, P446, DOI 10.1080/13651820600917294
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NR 18
TC 3
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0934-0874
EI 1432-2277
J9 TRANSPL INT
JI Transpl. Int.
PD MAR
PY 2011
VL 24
IS 3
BP e23
EP e27
DI 10.1111/j.1432-2277.2010.01198.x
PG 5
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 714WC
UT WOS:000286838700002
PM 21129043
DA 2026-07-24
ER

PT J
AU Taub, PJ
   Schulman, MR
   Sett, S
   Koch, RM
AF Taub, PJ
   Schulman, MR
   Sett, S
   Koch, RM
TI Revisiting vascularized muscle flaps for complicated sternal wounds in
   children
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal; wound; pediatric; muscle; flap
ID VACUUM-ASSISTED CLOSURE; DELAY PHENOMENON
AB Surgeons at our center previously reported a case of a 2-month-old infant who underwent closure of an infected sternal wound following open cardiac surgery with debridement followed by closure with bilateral pectoralis muscle flaps and a unilateral rectus abdominis muscle flap. The success of the procedure has spawned refinements in the technique, such as the one described herein. A 2-week-old neonate was evaluated for postoperative sternal dehiscence and instability following open cardiac surgery or severe congenital cardiac anomalies. Management included initial debridement and application of a vacuum-assisted closure (V.A.C.) system (KCI, Oxfordshire, UK). In conjunction with the final V.A.C. dressing change, the patient underwent delay of the left rectus muscle by division of the inferior epigastric pedicle. She subsequently underwent transposition of the left rectus muscle and application of a full-thickness skin graft for coverage of the sternal defect. She has since done well and still requires further invasive cardiac procedures.
C1 New York Med Coll, Div Plast & Reconstruct Surg, Valhalla, NY 10595 USA.
   Westchester Cty Med Ctr, Maria Fareri Childrens Hosp, Valhalla, NY 10595 USA.
C3 New York Medical College; Westchester Medical Center
RP Taub, PJ (通讯作者)，New York Med Coll, Div Plast & Reconstruct Surg, Macy Pavil, Valhalla, NY 10595 USA.
EM peter@pjtaub.com
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   CALLEGARI PR, 1992, PLAST RECONSTR SURG, V89, P397, DOI 10.1097/00006534-199203000-00001
   Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   HALLOCK GG, 1995, PLAST RECONSTR SURG, V96, P233, DOI 10.1097/00006534-199507000-00053
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Sung K, 1998, ANN PLAS SURG, V40, P523, DOI 10.1097/00000637-199805000-00015
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   TAYLOR GI, 1992, PLAST RECONSTR SURG, V89, P408, DOI 10.1097/00006534-199203000-00002
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   WEINZWEIG N, 1995, ANN PLAS SURG, V34, P471, DOI 10.1097/00000637-199505000-00004
NR 12
TC 8
Z9 9
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2005
VL 55
IS 5
BP 535
EP 537
DI 10.1097/01.sap.0000183681.56595.0a
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 979HC
UT WOS:000232932000020
PM 16258310
DA 2026-07-24
ER

PT J
AU Dosluoglu, HH
   Schimpf, DK
   Schultz, R
   Cherr, GS
AF Dosluoglu, HH
   Schimpf, DK
   Schultz, R
   Cherr, GS
TI Preservation of infected and exposed vascular grafts using vacuum
   assisted closure without muscle flap coverage
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 19th Annual Meeting of the Eastern-Vascular-Society
CY MAY 05-07, 2005
CL Pittsburgh, PA
SP Eastern Vasc Soc
ID NEGATIVE-PRESSURE; GROIN; MANAGEMENT; EXPERIENCE; SURGERY; THERAPY;
   BYPASS
AB The most widely used techniques for graft preservation after localized graft infections are muscle flap closure or antibacterial dressings and irrigations after debridement. Vacuum assisted closure (VAC has been increasingly used for complex wounds in vascular surgery, including groin infections, but not directly on exposed bypass grafts as a stand-alone technique. We used the VAC system after wound debridement in four patients with fully exposed synthetic bypass grafts who were too unstable or risky for further operative interventions. Mean duration of VAC use was 22.8 days (range, 6 to 5 3 days), with time to total wound closure of 30 to 63 days (mean, 41 days). There were no reinfections with I I to 25 months' follow-up (mean, 18.3 months). For high-risk surgical patients with a fully exposed infected prosthetic vascular graft, VAC therapy along with aggressive debridement and antibiotic therapy may be an effective alternative to current management strategies.
C1 SUNY Buffalo, Dept Surg, Buffalo, NY 14260 USA.
   Vet Affairs Med Ctr, Dept Vasc Surg, Buffalo, NY USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   US Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Dosluoglu, HH (通讯作者)，VA Western NY Healthcare Syst, Div Vasc Surg, 3495 Bailey Ave, Buffalo, NY 14215 USA.
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   Colwell AS, 2004, ANN PLAS SURG, V52, P49, DOI 10.1097/01.sap.0000099960.68038.53
   Demaria R, 2001, J Wound Care, V10, P12
   Demaria RG, 2003, J CARDIOVASC SURG, V44, P757
   EDWARDS WH, 1987, J VASC SURG, V6, P235, DOI 10.1067/mva.1987.avs0060235
   Giovannini UM, 2001, ANN PLAS SURG, V47, P577, DOI 10.1097/00000637-200111000-00022
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Taylor SM, 1996, ANN VASC SURG, V10, P117, DOI 10.1007/BF02000754
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NR 17
TC 60
Z9 63
U1 0
U2 0
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2005
VL 42
IS 5
BP 989
EP 992
DI 10.1016/j.jvs.2005.07.006
PG 4
WC Surgery; Peripheral Vascular Disease
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 981LL
UT WOS:000233090000035
PM 16275458
DA 2026-07-24
ER

PT J
AU Canavese, F
   Gupta, S
   Krajbich, JI
   Emara, KM
AF Canavese, F.
   Gupta, S.
   Krajbich, J. I.
   Emara, K. M.
TI Vacuum-assisted closure for deep infection after spinal instrumentation
   for scoliosis
SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
LA English
DT Article
ID SOFT-TISSUE DEFECTS; WOUND INFECTIONS; MANAGEMENT; FUSION; ADULTS
AB Our aim was to review the efficacy of the wound vacuum-assisted closure (VAC) system in the treatment of deep infection after extensive instrumentation and fusion for spinal deformity in children and adolescents.
   A total of 14 patients with early deep spinal infection were treated using this technique. Of these, 12 had neuromuscular or syndromic problems. Clinical and laboratory data were reviewed. The mean follow-up was 44 months (24 to 72). All wounds healed. Two patients required plastic surgery to speed up the process. In no patient was the hardware removed and there was no loss of correction or recurrent infection.
   We believe that the wound VAC system is a useful tool in the armamentarium of the spinal surgeon dealing with patients susceptible to wound infections, especially those with neuromuscular diseases. It allows for the retention of the instrumentation and the maintenance of spinal correction. It is reliable and easy to use.
C1 [Canavese, F.; Gupta, S.; Krajbich, J. I.] Shriners Hosp Children, Dept Pediat Orthopaed, Portland, OR 97237 USA.
RP Canavese, F (通讯作者)，Shriners Hosp Children, Dept Pediat Orthopaed, 3101 SW Sam Jackson Pk Rd, Portland, OR 97237 USA.
EM canavese_federico@yahoo.fr
RI ; Emara, Khaled/Q-1008-2019; Gupta, Subhas/C-5458-2018
OI CANAVESE, Federico/0000-0002-6114-5372; Emara,
   Khaled/0000-0001-7060-0325; Gupta, Subhas/0000-0001-5091-3922
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   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
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   Malamo-Lada Helen, 1999, Clin Microbiol Infect, V5, P135, DOI 10.1111/j.1469-0691.1999.tb00526.x
   MCCARTHY JJ, 2006, J AM ACAD SURG, V14, P356
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   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
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   RICHARDS BS, 1999, SPINE S, V19, P1598
   Singh K, 2006, J BONE JOINT SURG BR, V88B, P8, DOI 10.1302/0301-620X.88B1.16837
   Soultanis K, 2003, CLIN ORTHOP RELAT R, P116, DOI 10.1097/01.blo.0000068357.47147.10
   Sriram K, 1972, J Bone Joint Surg Br, V54, P666
NR 18
TC 53
Z9 66
U1 0
U2 1
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 0301-620X
J9 J BONE JOINT SURG BR
JI J. Bone Joint Surg.-Br. Vol.
PD MAR
PY 2008
VL 90B
IS 3
BP 377
EP 381
DI 10.1302/0301-620X.90B3.19890
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 271FR
UT WOS:000253774800021
PM 18310764
OA Bronze
DA 2026-07-24
ER

PT J
AU Alvarez, AA
   Maxwell, GL
   Rodriguez, GC
AF Alvarez, AA
   Maxwell, GL
   Rodriguez, GC
TI Vacuum-assisted closure for cutaneous gastrointestinal fistula
   management
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
ID ENTEROCUTANEOUS FISTULA; WOUND CONTROL
AB Background. Cutaneous gastrointestinal (GI) fistulas are a challenging complication in the oncologic patient population. The fistulous effluent is difficult to manage and adversely alters quality of life. Nonsurgical management of enteric fistulas is successful in 30% of cases, requiring at least 4 to 6 weeks. Recently a new technology has been developed to expedite wound healing. The Vacuum-Assisted Closure (VAC) method is a subatmospheric pressure technique that has been demonstrated in laboratory and clinical studies to significantly improve wound healing. Here we report its use in the successful medical management of a cutaneous GI fistula.
   Case. A 63-year-old woman with advanced ovarian cancer developed an extensive complex cutaneous GI fistula in an open healing wound. She was treated with total parental nutrition and the VAC device, which resulted in complete closure of the fistula.
   Conclusion. We propose that the VAC device may be a useful adjunct for the medical management of cutaneous GI fistulas. (C) 2001 Academic Press.
C1 Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Durham, NC 27710 USA.
C3 Duke University
RP Alvarez, AA (通讯作者)，Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Box 3079, Durham, NC 27710 USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chamberlain RS, 1998, AM SURGEON, V64, P1204
   Chang P, 2000, SOUTH MED J, V93, P599
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 5
TC 52
Z9 62
U1 0
U2 2
PU ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2001
VL 80
IS 3
BP 413
EP 416
DI 10.1006/gyno.2000.6092
PG 4
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 410CM
UT WOS:000167422500017
PM 11263943
DA 2026-07-24
ER

PT J
AU Fukasawa, T
   Imaizumi, K
   Terashima, K
   Kasajima, H
   Furukawa, N
   Ito, K
   Odagiri, T
   Yamana, D
   Tsuruga, Y
   Umehara, M
   Kurushima, M
   Nakanishi, K
AF Fukasawa, Takumu
   Imaizumi, Ken
   Terashima, Kazutoshi
   Kasajima, Hiroyuki
   Furukawa, Naoe
   Ito, Keiichiro
   Odagiri, Tadashi
   Yamana, Daisuke
   Tsuruga, Yosuke
   Umehara, Minoru
   Kurushima, Michihiro
   Nakanishi, Kazuaki
TI Delayed Primary Skin Closure Followed by Single-use Negative-pressure
   Wound Therapy Is Optimal for Wound Management After Bowel-stoma Reversal
SO IN VIVO
LA English
DT Article
DE Stoma closure; surgical site infection; negative-pressure wound therapy;
   delayed primary closure
ID COMPLICATIONS; INFECTION; MORTALITY; LOOP
AB <bold>Background/Aim:</bold> Although the purse-string suture (PSS) method is widely adopted to reduce surgical-site infection (SSI; the commonest complication following bowel-stoma closure), this technique is associated with delayed epithelialization. Recently, delayed primary closure (DPC) combined with negative-pressure wound therapy (NPWT) has been proposed as a promising alternative. This study aimed to evaluate the clinical efficacy of DPC with NPWT compared to the PSS method in stoma-closure surgery. <bold>Patients and Methods:</bold> We conducted a retrospective observational study involving 31 patients who underwent stoma closure between January 2021 and March 2023. Patients were categorized into two groups: PSS with or without NPWT (PSS +/- NPWT; n=15) and DPC with NPWT (DPC+NPWT; n=16). The primary outcome was wound-healing duration; the secondary outcomes were patient satisfaction and in-hospital costs. <bold>Results:</bold> The wound-healing duration was significantly shorter in the DPC+NPWT group compared to the PSS +/- NPWT group (median: 20 vs. 45 days, p<0.001). Multivariate analysis identified wound-closure method as an independent predictor of wound healing at 30 days. Patient-reported outcomes indicated improved wound-care experience and a trend toward better cosmetic satisfaction in the DPC+NPWT group. Although not statistically significant, the total in-hospital costs were lower in the DPC+NPWT group despite higher device-related expenditures. <bold>Conclusion:</bold> DPC with NPWT significantly shortened the wound-healing duration and showed potential benefits regarding patient satisfaction and healthcare costs compared to the PSS method. These findings suggest DPC with NPWT as a viable alternative for bowel-stoma closure and wound management.
C1 [Fukasawa, Takumu; Imaizumi, Ken; Kasajima, Hiroyuki; Ito, Keiichiro; Odagiri, Tadashi; Yamana, Daisuke; Tsuruga, Yosuke; Umehara, Minoru; Kurushima, Michihiro; Nakanishi, Kazuaki] Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
   [Terashima, Kazutoshi; Furukawa, Naoe] Hakodate Municipal Hosp, Dept Wound Ostomy & Continence Nurse, Hakodate, Hokkaido, Japan.
RP Imaizumi, K (通讯作者)，Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
EM imaken1983@gmail.com
RI Imaizumi, Ken/ABW-2302-2022
CR Akiyoshi T, 2010, WORLD J SURG, V34, P1937, DOI 10.1007/s00268-010-0547-8
   [Anonymous], 2018, Global guidelines for the prevention of surgical site infection, V2nd
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   Kawashima J, 2023, SURG TODAY, V53, P728, DOI 10.1007/s00595-022-02631-3
   Kojima K, 2021, BMC SURG, V21, DOI 10.1186/s12893-021-01446-2
   Maguire B, 2022, COLORECTAL DIS, V24, P811, DOI 10.1111/codi.16099
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   Tiang T, 2024, ANZ J SURG, V94, P1627, DOI 10.1111/ans.18941
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   Yoon SI, 2015, ANN COLOPROCTOL, V31, P29, DOI 10.3393/ac.2015.31.1.29
NR 25
TC 1
Z9 1
U1 0
U2 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2025
VL 39
IS 6
BP 3418
EP 3427
DI 10.21873/invivo.14139
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 9KB6N
UT WOS:001608235100030
PM 41167677
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Diehm, YF
   Loew, J
   Will, PA
   Fischer, S
   Hundeshagen, G
   Ziegler, B
   Gazyakan, E
   Kneser, U
   Hirche, C
AF Diehm, Yannick F.
   Loew, Julia
   Will, Patrick A.
   Fischer, Sebastian
   Hundeshagen, Gabriel
   Ziegler, Benjamin
   Gazyakan, Emre
   Kneser, Ulrich
   Hirche, Christoph
TI Negative pressure wound therapy with instillation and dwell time
   (NPWTi-d) with V. A. C.VeraFloin traumatic, surgical, and chronic
   wounds-A helpful tool for decontamination and to prepare successful
   reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bacterial colonisation; dwell time; NPWTi-d; wounds; instillation;
   negative pressure wound therapy; reconstruction
ID SALINE INSTILLATION
AB For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well as wound bed preparation. The addition of instillation and dwell time as an adjunct to NPWT (NPWTi-d) enables wound bed cleaning and improved wound bed granulation. Thirty patients with different types of colonised wounds (traumatic, surgical, and chronic) were treated with NPWTi-d using saline for instillation. Patient data, microbiological data and wound characteristics were collected and analysed. Endpoints were bacterial decontamination (count and type), effect on wound bed granulation, and successful reconstruction. Additionally, subgroup analyses for traumatic, surgical, and chronic wounds as well as patients pretreated with conventional NPWT or isolated gram-positive or negative germs were performed. NPWTi-d was applied on average for 13 days with a total hospitalisation time of 51 days. After NPWTi-d, decontaminated wounds were detected in 23% of cases. The number of different bacteria as well as bacterial count could be significantly reduced from 2.38 to 1.16 and 3.9 to 1.3, respectively. This was similar for all subgroups except surgical wounds, in which NPWTi-d did not lead to a significant reduction of the bacterial count. NPWTi-d resulted in a significant stimulation of granulation tissue. Successful reconstruction was achieved in 90% of cases. NPWTi-d enabled wound pre-conditioning by powerfully reducing or decontaminating the bacterial load and spectrum in most of the wounds. The wound bed integrity was re-established to prepare successful reconstruction.
C1 [Diehm, Yannick F.; Loew, Julia; Will, Patrick A.; Fischer, Sebastian; Hundeshagen, Gabriel; Ziegler, Benjamin; Gazyakan, Emre; Kneser, Ulrich; Hirche, Christoph] BG Trauma Ctr Ludwigshafen, Burn Ctr, Dept Hand Plast & Reconstruct Surg, Microsurg, Ludwigshafen, Germany.
   [Diehm, Yannick F.; Loew, Julia; Will, Patrick A.; Fischer, Sebastian; Hundeshagen, Gabriel; Ziegler, Benjamin; Gazyakan, Emre; Kneser, Ulrich; Hirche, Christoph] Heidelberg Univ, Hand & Plast Surg, Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Hirche, C (通讯作者)，Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Microsurg, Burn Ctr,BG Trauma Ctr, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM christoph.hirche@bgu-ludwigshafen.de
RI Will, Patrick/KHX-8668-2024; Gazyakan, Emre/HLW-5585-2023
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   De Vries FEE, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004673
   Ferreira Marcus Castro, 2006, Clinics, V61, P571, DOI 10.1590/S1807-59322006000600014
   Fluieraru S, 2013, J WOUND CARE, V22, P293, DOI 10.12968/jowc.2013.22.6.293
   Gabriel Allen, 2014, Eplasty, V14, pe41
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Goss S G, 2012, J Am Coll Clin Wound Spec, V4, P74, DOI 10.1016/j.jccw.2014.02.001
   Horch RE, 2018, ZBL CHIR, V143, P609, DOI 10.1055/a-0713-0517
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   Leung BK, 2010, WOUNDS, V22, P179
   Ludolph I, 2018, INT WOUND J, V15, P978, DOI 10.1111/iwj.12958
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Rycerz AM, 2013, INT WOUND J, V10, P20, DOI 10.1111/iwj.12171
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
NR 16
TC 24
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1740
EP 1749
DI 10.1111/iwj.13462
EA JUL 2020
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000552421100001
PM 32716140
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Moncrieff, MD
   Sharma, RA
   Gathura, E
   Heaton, MJ
AF Moncrieff, Marc D.
   Sharma, Riti A.
   Gathura, Esther
   Heaton, Martin J.
TI Improved Perioperative Seroma and Complication Rates Following the
   Application of a 2-Layer Negative Pressure Wound Therapy System After
   Inguinal Lymphadenectomy for Metastatic Cutaneous Melanoma
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID LYMPH; PREVENTION; DISSECTION; MORBIDITY; COHORT
AB Background Perioperative complications following inguinal lymphadenectomy, including seroma formation, are frequent. We have employed a 2-layer negative pressure wound therapy (2-LNPWT) as a method to reduce seroma rate and perioperative complications. We present the outcome of our initial experience with 2-LNPWT and compare the outcomes of its use with traditional closed suction drains (CSDs). Materials and methods A non-randomised retrospective case-control series was analysed. Surgeons performing inguinal lymphadenectomy for metastatic cutaneous melanoma utilised either the 2-LNPWT therapy or traditional CSDs according to their practice preference. Results The study included 111 patients. The cohorts were well matched for gender, disease burden, body mass index and comorbidities. The 2-LNPWT technique was associated with significantly better postoperative outcomes than CSD, in terms of incidence of seroma formation (26.9% vs 49.4%; p < 0.03), period of drainage (15 days vs 20 days; p = 0.005) and return to theatre rate (0% vs 15.3%; p = 0.03). The overall seroma rate was 44.1%. The only significant association with seroma initiation was the type of drainage system used (2-LNPWT 31.2% vs CSD 58.3%; p < 0.03; OR 3.0). The method of drainage did not alter the course of an established seroma. There was no significant difference in overall or disease-specific survival detected between the 2 groups. Conclusion This retrospective non-randomised case control study has demonstrated the safe use of a novel application of negative pressure wound therapy that significantly reduced the incidence of seroma formation and postoperative complication rate for inguinal lymphadenectomy for melanoma.
C1 [Moncrieff, Marc D.; Sharma, Riti A.; Gathura, Esther; Heaton, Martin J.] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Plast & Reconstruct Surg, Norwich, Norfolk, England.
   [Moncrieff, Marc D.; Sharma, Riti A.] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
C3 Norfolk & Norwich University Hospitals NHS Foundation Trust; University
   of East Anglia
RP Moncrieff, MD (通讯作者)，Norfolk & Norwich Univ Hosp NHS Fdn Trust, Dept Plast & Reconstruct Surg, Norwich, Norfolk, England.; Moncrieff, MD (通讯作者)，Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
EM marc.moncrieff@nnuh.nhs.uk
OI Moncrieff, Marc/0000-0003-4492-235X
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Cai SS, 2017, INT WOUND J, V14, P661, DOI 10.1111/iwj.12665
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   Dindo D, 2008, WORLD J SURG, V32, P939, DOI 10.1007/s00268-008-9584-y
   Gerken ALH, 2019, J SURG ONCOL, V119, P728, DOI 10.1002/jso.25366
   Gié O, 2017, BMC SURG, V17, DOI 10.1186/s12893-017-0222-1
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   Janis JE, 2016, PLAST RECONSTR SURG, V138, P240, DOI 10.1097/PRS.0000000000002245
   Jorgensen MG, 2019, J PLAST RECONSTR AES, V72, P1178, DOI 10.1016/j.bjps.2019.02.013
   Jorgensen MG, 2018, J PLAST RECONSTR AES, V71, P590, DOI 10.1016/j.bjps.2017.11.026
   Kotha Vikas, 2019, Surg Technol Int, V34, P49
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NR 20
TC 5
Z9 7
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD OCT
PY 2020
VL 27
IS 10
BP 3692
EP 3701
DI 10.1245/s10434-020-08513-7
EA JUN 2020
PG 10
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA NJ1JU
UT WOS:000538488200002
PM 32504367
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lv, ZM
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Pelnac® Artificial Dermis Assisted by VSD for Treatment of Complex Wound
   with Bone/Tendon Exposed at the Foot and Ankle, A Prospective Study
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE Pelnac; artificial dermis; vacuum sealing drainage (VSD); large skin and
   soft-tissue defect; prospective study
ID TISSUE DEFECTS; RECONSTRUCTION; SKIN; SUBSTITUTE; MANAGEMENT; CLOSURE
AB Purpose:This study aims to assess the efficacy and safety of Pelnac dermal regeneration template assisted by vacuum sealing drainage (VSD) and a split-thickness skin graft to cover the large skin and soft-tissue defects at foot and ankle.Methods:This study began from March 2013, up to February 2017. A total of 16 patients met the inclusion and exclusion criteria and were included. For every patient, 2 separate operations were performed, the first being thorough debridement of necrotic tissues immediate coverage of VSD at continuous negative pressure suction, and the second being the autologous split-thickness skin graft. At each follow-up, relevant data were documented.Results:The average follow-up was 16.5 months (range, 12 to 42 months). No infections, hematoma, or seroma were observed. 13 out of 16 patients had a complete skin graft "take" (100%). Patients' satisfaction of esthetic appearance was 76.5 +/- 5.2/100. The VSS value was 2.2 +/- 2.1, representing a good result. Regarding the sensory recovery, the response "normal or near normal" could be obtained in 14/16 patients. Mean AROM for extension/flexion of the ankle was 48.5 +/- 4.8 degrees (range 35-62 degrees), and 93.7% (15/16) of patient could obtain a satisfying functional result.Conclusions:Our report indicated Pelnac provided an effective method for management of complex wounds with underlying bone or tendons exposed.
C1 [Lv, Zhenmu; Ding, Wenyuan; Shen, Yong] Hebei Med Univ, Dept Spine Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui] Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Baoding 071000, Hebei, Peoples R China.
   [Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Hebei Medical University
RP Lv, ZM (通讯作者)，Hebei Med Univ, Dept Spine Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.; Lv, ZM (通讯作者)，Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Baoding 071000, Hebei, Peoples R China.
OI Ding, Wenyuan/0000-0002-7257-4316
CR Baryza Mary Jo, 1995, Journal of Burn Care and Rehabilitation, V16, P535, DOI 10.1097/00004630-199509000-00013
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   冯亚高, 2013, [中华显微外科杂志, Chinese Journal of Microsurgery], V36, P87
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   Suzuki S, 2013, J PLAST RECONSTR AES, V66, pE229, DOI 10.1016/j.bjps.2013.03.018
   Taras JS, 2010, J HAND SURG-AM, V35A, P415, DOI 10.1016/j.jhsa.2009.12.008
   YANNAS IV, 1980, J BIOMED MATER RES, V14, P65, DOI 10.1002/jbm.820140108
   Yeong EK, 2006, BURNS, V32, P375, DOI 10.1016/j.burns.2005.08.015
   [张功林 Zhang Gonglin], 2012, [中华小儿外科杂志, Chinese Journal of Pediatric Surgery], V33, P122
NR 24
TC 23
Z9 30
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD AUG 8
PY 2020
VL 33
IS 7
BP 636
EP 641
DI 10.1080/08941939.2018.1536177
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NR4BY
UT WOS:000571509200008
PM 32643478
DA 2026-07-24
ER

PT J
AU Figueroa, NS
   Mullen, B
   Rios-Sanchez, M
   Brakke, H
   Martinez-Jorge, J
   Fahradyan, V
AF Figueroa, Nicole Sanchez
   Mullen, Barbara
   Rios-Sanchez, Maria
   Brakke, Holly
   Martinez-Jorge, Jorys
   Fahradyan, Vahe
TI Negative pressure wound therapy vs. standard dressings in penile
   inversion vaginoplasty: Provider perspectives on challenges, benefits,
   and workload
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Penile inversion vaginoplasty; Negative pressure wound therapy; Nursing
   workload; Gender-affirming surgery; Postoperative care; Wound management
AB Penile inversion vaginoplasty (PIV) is the most common genital gender-affirming surgery for transfeminine individuals. Postoperative wound care often involves either traditional bolster dressings or incisional negative pressure wound therapy (iNPWT). While iNPWT has shown potential benefits in wound healing and infection reduction, its impact on nursing workload and practical application in perineal wounds remains underexplored. This study aims to evaluate nursing experiences with iNPWT compared to standard bolster dressings following PIV. A cross-sectional survey was conducted among floor nurses at a single institution with experience managing postoperative PIV patients. The survey assessed challenges encountered with each dressing method, strategies used to address complications, perceived workload, satisfaction, and observations on patient comfort. Descriptive statistics and thematic analysis were used to analyze the data. Sixteen nurses responded (59% response rate), most with >= 3 years of transgender surgical care experience. Overall, 81% reported satisfaction with iNPWT, and 47% perceived it as less burdensome than bolster dressings. Device malfunction, primarily due to air leaks, was the most common issue (81%). However, iNPWT was associated with improved hygiene and reduced need for dressing changes. Nurses employed strategies such as enhanced sealing techniques and increased monitoring to troubleshoot challenges. Despite early technical difficulties, iNPWT was well-received by nursing staff, offering workflow advantages and increased patient comfort. Findings suggest iNPWT is a feasible alternative to bolster dressings in PIV and highlight the importance of nursing support and training for successful implementation. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Figueroa, Nicole Sanchez; Mullen, Barbara; Rios-Sanchez, Maria; Brakke, Holly; Martinez-Jorge, Jorys; Fahradyan, Vahe] Mayo Clin, Dept Surg, Div Plast Surg, 200 1st St SW, Rochester, MN 55905 USA.
   [Figueroa, Nicole Sanchez] Univ Especialidades Espiritu Santo, Samborondon, Ecuador.
C3 Mayo Clinic; Universidad de Especialidades Espiritu Santo
RP Fahradyan, V (通讯作者)，Mayo Clin, Dept Surg, Div Plast Surg, 200 1st St SW, Rochester, MN 55905 USA.
EM fahradyan.vahe@mayo.edu
RI sanchez, nicole/PGU-4587-2026
OI brakke, holly/0000-0001-5644-7934; Fahradyan, Vahe/0000-0003-4315-7932
CR Hu J, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001726
   Li JS, 2021, INT BRAZ J UROL, V47, P263, DOI [10.1590/S1677-5538.IBJU.2020.0338, 10.1590/s1677-5538.ibju.2020.0338]
   Norman G, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub7
   Przybek-Mita Joanna, 2023, Int J Environ Res Public Health, V20, DOI [10.3390/ijerph20043388, 10.3390/ijerph20043388]
   Sanchez MVR, 2024, PRS-GLOB OPEN, V12, P63, DOI [10.1097/01.gox.0001015472.19190.47, 10.1097/01.Gox.0001015472.19190.47, DOI 10.1097/01.GOX.0001015472.19190.47]
NR 5
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD APR
PY 2026
VL 115
BP 495
EP 498
DI 10.1016/j.bjps.2025.09.019
EA APR 2026
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GN6XM
UT WOS:001740722800001
PM 41219073
DA 2026-07-24
ER

PT J
AU Xing, WQ
   Yang, Y
   Bai, Y
   Yu, XC
   Chang, ZQ
AF Xing, Wenqiang
   Yang, Yang
   Bai, Yun
   Yu, Xiuchun
   Chang, Zhengqi
TI A Comparison of Negative Pressure and Conventional Therapy in Spine
   Infections: A Single-Center Retrospective Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE spondylodiscitis; clinical outcome; negative pressure wound
   therapy(NPWT); spinal infection
ID BACTERIAL BIOFILM; WOUND THERAPY; MANAGEMENT; TUBERCULOSIS; SURGERY;
   BIOPSY; YIELD
AB Purpose: To investigate the effectiveness and safety of negative-pressure wound therapy (NPWT) in treating primary spinal infections. Methods: Patients who underwent surgical treatment for primary spinal infection between January 2018 and June 2021 were retrospectively evaluated. They were divided into two groups based on the type of surgery: one that underwent negative-pressure wound therapy (NPWT) and another that underwent conventional surgery (CVSG-Posterior debridement, bone grafting, fusion, and internal fixation in one stage). The two groups were compared in terms of the total operation time, total blood loss, total postoperative drainage, postoperative pain score, time for the postoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to return to normal, postoperative complications, treatment time, and recurrence rate. Results: A total of 43 cases of spinal infection were evaluated, with 19 in the NPWT group and 24 in the CVSG group. The NPWT group had a superior postoperative drainage volume, antibiotic use time, erythrocyte sedimentation rate and CRP recovery times, VAS score at 3 months after the operation, and cure rate at 3 months after operation compared with the CVSG group. There were no significant variations in the total hospital stay and intraoperative blood loss between the two groups. Conclusions: This study supports the use of negative pressure in the treatment of a primary spinal infection and indicates that it has a notably better short-term clinical effect than conventional surgery. Additionally, its mid-term cure rate and recurrence rate are more desirable than those of conventional treatments.
C1 [Xing, Wenqiang; Yang, Yang; Bai, Yun; Yu, Xiuchun; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan 250031, Peoples R China.
   [Bai, Yun] 80th Grp Army Hosp PLA, Dept Orthoped, Weifang 261000, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan 250031, Peoples R China.
EM changzq960@163.com
RI ; Xing, Wenqiang/MBW-3134-2025
OI chang, zhengqi/0000-0001-6490-2239; 
CR Aljawadi A, 2019, J ORTHOP, V16, P508, DOI 10.1016/j.jor.2019.08.014
   Babic M, 2017, INFECT DIS CLIN N AM, V31, P279, DOI 10.1016/j.idc.2017.01.003
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   Butler JS, 2006, SPINE, V31, P2695, DOI 10.1097/01.brs.0000244662.78725.37
   Chandra SP, 2013, WORLD NEUROSURG, V80, P190, DOI 10.1016/j.wneu.2012.12.019
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   Kafle G, 2022, BONE JOINT J, V104B, P120, DOI 10.1302/0301-620X.104B1.BJJ-2021-0848.R2
   Lew DP, 2004, LANCET, V364, P369, DOI 10.1016/S0140-6736(04)16727-5
   Loibl M, 2014, INFECTION, V42, P503, DOI 10.1007/s15010-013-0582-0
   Luo XB, 2015, J ORTHOP SURG RES, V10, DOI 10.1186/s13018-015-0250-4
   Ma H D, 2017, Zhonghua Yi Xue Za Zhi, V97, P212, DOI 10.3760/cma.j.issn.0376-2491.2017.03.011
   McNamara AL, 2017, AM J NEURORADIOL, V38, P2021, DOI 10.3174/ajnr.A5337
   Mueller KB, 2021, NEUROSURGERY, V88, pE445, DOI 10.1093/neuros/nyab040
   Nagashima H, 2012, INT ORTHOP, V36, P1229, DOI 10.1007/s00264-011-1440-2
   O'Daly BJ, 2008, SPINE, V33, pE246, DOI 10.1097/BRS.0b013e31816b8872
   Sobottke R, 2008, DTSCH ARZTEBL INT, V105, P181, DOI 10.3238/arztebl.2008.0181
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   Zhang L, 2020, EXP THER MED, V20, P2305, DOI 10.3892/etm.2020.8941
NR 23
TC 10
Z9 10
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2023
VL 13
IS 2
AR 162
DI 10.3390/jpm13020162
PG 8
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 9J8HF
UT WOS:000940420100001
PM 36836397
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Morris, MP
   Christopher, AN
   Patel, V
   Onyekaba, G
   Broach, RB
   Fischer, JP
AF Morris, Martin P.
   Christopher, Adrienne N.
   Patel, Viren
   Onyekaba, Ginikanwa
   Broach, Robyn B.
   Fischer, John P.
TI Negative Pressure Wound Therapy After Abdominal Body Contouring: A
   Comparative Matched Analysis of Outcomes and Cost
SO PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; body contouring; cost; post-operative
   outcomes
ID MASS INDEX; SURGICAL INCISIONS; MANAGEMENT
AB Background:
   Studies that have previously validated the use of incisional negative pressure wound therapy (iNPWT) after body contouring procedures (BCP) have provided limited data regarding associated health care utilization and cost. We matched 2 cohorts of patients after BCP with and without iNPWT and compared utilization of health care resources and post-operative clinical outcomes.
   Methods:
   Adult patients who underwent abdominoplasty and/or panniculectomy between 2015 and 2020 by a single surgeon were identified. Patients were propensity score matched by body mass index (BMI), gender, smoking history, diabetes mellitus, hypertension, and incision type. Primary outcomes included time to final drain removal, outpatient visits, homecare visits, emergency department visits, and cost. Secondary outcomes included surgical site occurrences (SSO), surgical site infections, reoperations, and revisions.
   Results:
   One hundred sixty-six patients were eligible, and 40 were matched (20 with iNPWT and 20 without iNPWT) with a median age of 47 years and BMI of 32 kg/m(2). There were no differences in demographics or intraoperative details (all P > .05). No significant differences were found between the cohorts in terms of health care utilization measures or clinical outcomes (all P > .05). Direct cost was significantly greater in the iNPWT cohort (P = .0498). Inpatient length of stay and procedure time were independently associated with increased cost on multivariate analysis (all P < .0001).
   Conclusion:
   Consensus guidelines recommend the use of iNPWT in high-risk patients, including abdominal BCP. Our results show that iNPWT is associated with equivalent health care utilization and clinical outcomes, with increased cost. Additional randomized controlled trials are needed to further elucidate the cost utility of this technique in this patient population.
C1 [Morris, Martin P.; Christopher, Adrienne N.; Patel, Viren; Onyekaba, Ginikanwa; Broach, Robyn B.; Fischer, John P.] Univ Penn, Dept Surg, Div Plast Surg, Philadelphia, PA 19104 USA.
   [Christopher, Adrienne N.] Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA.
C3 University of Pennsylvania; Thomas Jefferson University
RP Morris, MP (通讯作者)，Univ Penn Hlth Syst, Dept Surg, Div Plast Surg, 3400 Civ Ctr Blvd,South Pavilion 14th Floor, Philadelphia, PA 19104 USA.
EM momarti@pennmedicine.upenn.edu
OI Morris, Martin/0000-0002-4552-1411
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
   [Anonymous], 2020, PREVENATM THERAPY
   Arora Vineet, 2015, AMA J Ethics, V17, P1046, DOI [10.1001/journalofethics.2015.17.11.stas1-1511, 10.1001/journalofethics.2015.17.11.stas1-1511]
   Arthurs ZM, 2007, AM J SURG, V193, P567, DOI 10.1016/j.amjsurg.2007.01.006
   ASPS, 2020, STATISTICS-ABINGDON
   Tran BNN, 2019, J SURG RES, V241, P63, DOI 10.1016/j.jss.2019.03.033
   Brisinda, 2020, SURGERY, P30511
   Brito IM, 2020, AESTHET PLAST SURG, V44, P1615, DOI 10.1007/s00266-020-01725-y
   Desvigne MN, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9341
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   Singh D, 2019, PLAST RECONSTR SURG, V143, p11S, DOI 10.1097/PRS.0000000000005306
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   de Macedo JLS, 2020, OBES SURG, V30, P4149, DOI 10.1007/s11695-020-04711-0
   Toma T, 2018, OBES SURG, V28, P3333, DOI 10.1007/s11695-018-3323-8
   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
   Zannis J, 2012, ANN PLAS SURG, V68, P194, DOI 10.1097/SAP.0b013e318212f39a
   Zuelzer HB, 2010, ANN PLAS SURG, V64, P598, DOI 10.1097/SAP.0b013e3181cf9f9e
   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 37
TC 5
Z9 5
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD NOV
PY 2022
VL 30
IS 4
BP 360
EP 367
AR 22925503211019627
DI 10.1177/22925503211019627
EA JUN 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5C3YO
UT WOS:000657994500001
PM 36212102
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kang, SI
   Kim, S
AF Kang, Sung Il
   Kim, Sohyun
TI The effectiveness of negative-pressure wound therapy for wound healing
   after stoma reversal: a randomized control study
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Article
DE Colostomy; Ileostomy; Negative-pressure wound therapy
ID SURGICAL SITE INFECTION; PURSESTRING CLOSURE; LAPAROTOMY; TRIAL; RISK
AB Purpose: The purse-string closure (PSC) method is used for skin closure after stoma reversal to reduce surgical site infections (SSIs). However, PSC requires a longer healing period than primary closure. The application of negative-pressure wound therapy (NPWT) may reduce the healing period of many wound types. This study aimed to investigate whether the application of NPWT promotes wound healing after the PSC method for stoma reversal.Methods: This study was a randomized controlled study. Patients who had undergone stoma reversal surgery were randomized to receive NPWT or simple dressing after surgery. The primary outcome was a complete wound-healing period. We also investigated SSI, hospital stay, total cost, and the patient and observer scar assessment scale (POSAS) as secondary outcomes.Results: A total of 36 patients were randomized into 2 groups. The median wound healing period was shorter in the NPWT group than in the control group (17.5 days [range, 11-24 days] vs. 21.5 days [range, 14-41 days], P = 0.006). SSI rate and hospital stay did not differ between the groups. However, the number of dressings was lower in the NPWT group than in the control group (5 [range, 3-7] vs. 17 [range, 10-30], P < 0.001). The total cost for dressing was comparable between the groups. The POSAS was not different between the groups.Conclusion: This study revealed that NPWT application after PSC for stoma reversal site is effective in reducing the wound healing period compared to simple dressing, without increasing SSI and total cost.
C1 [Kang, Sung Il; Kim, Sohyun] Yeungnam Univ, Med Ctr, Dept Orthopaed Surg, Coll Med, Daegu, South Korea.
   [Kang, Sung Il] Yeungnam Univ, Coll Med, Med Ctr, Dept Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University; Yeungnam University
RP Kang, SI (通讯作者)，Yeungnam Univ, Coll Med, Med Ctr, Dept Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM sungiry@naver.com
OI Kang, Sung Il/0000-0002-4751-5779
FU 2021 Yeungnam University Research Grant program [221A580020]
FX This work was supported by non-profit grants from the 2021 Yeungnam
   University Research Grant program (221A580020).
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   Lee JT, 2014, DIS COLON RECTUM, V57, P1282, DOI 10.1097/DCR.0000000000000209
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NR 21
TC 12
Z9 12
U1 1
U2 5
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD SEP
PY 2023
VL 105
IS 3
BP 126
EP 132
DI 10.4174/astr.2023.105.3.126
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S9JG8
UT WOS:001074250100002
PM 37693285
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Renno, I
   Boos, AM
   Horch, RE
   Ludolph, I
AF Renno, Isabell
   Boos, Anja M.
   Horch, Raymund E.
   Ludolph, Ingo
TI Changes of perfusion patterns of surgical wounds under application of
   closed incision negative pressure wound therapy in postbariatric
   patients
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Skin perfusion patterns; combined laser Doppler spectrophotometry; ICG
   angiography; oxygen saturation; relative hemoglobin content; wound
   healing; O2C; SPY; weight loss; obesity; maintenance of weight loss;
   body contouring surgery; abdominoplasty; postoperative complications;
   closed incisional negative pressure wound therapy; ciNPWT; ciNPT; NPWT;
   postbariatric surgery; postoperative wound care; high-risk patients
ID LASER-DOPPLER SPECTROPHOTOMETRY; ABDOMINAL-WALL PERFUSION; BREAST
   RECONSTRUCTION; TISSUE PERFUSION; BLOOD-FLOW; BODY-MASS; COMPLICATIONS;
   ABDOMINOPLASTY; SURGERY; OUTCOMES
AB BACKGROUND: Negative pressure wound therapy applied over closed incisions (ciNPT) has been shown to influence wound healing. Therefore, the aim of this study was to examine the short-term effects of ciNPT on skin perfusion patterns in postbariatric wounds.
   METHODS: 17 patients were included. Patients from the study group received a ciNPT dressing with a continuous negative pressure of -125 mmHg for five days. Two intra- and two postoperative measurements were performed using both a combined laser Doppler spectrophotometry and an ICG angiography system to determine oxygen saturation (sO2), hemoglobin content (rHb) and perfusion patterns.
   RESULTS: Three days postoperatively the sO2 was significantly higher in the study group compared to the control group and also compared to the end of the operation. Concerning the rHb, there was no statistical significant alteration in or between the groups, but a trend towards a correlated alteration of sO2 and rHb. ICG angiography showed an earlier and stronger enhancement of perfusion parameters in the study group.
   CONCLUSION: CiNPT has a positive effect on oxygen saturation and tissue perfusion, which are both associated with the wound healing process. The use of ciNPT could therefore possibly reduce the risk of wound healing complications in this high-risk patient group.
C1 [Renno, Isabell; Boos, Anja M.; Horch, Raymund E.; Ludolph, Ingo] Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Plast & Hand Surg, Univ Hosp Erlangen, Erlangen, Germany.
   [Boos, Anja M.] Rhein Westfal TH Aachen, Dept Plast Surg Hand & Burn Surg, Univ Hosp Aachen, Aachen, Germany.
C3 University of Erlangen Nuremberg; RWTH Aachen University; RWTH Aachen
   University Hospital
RP Ludolph, I (通讯作者)，Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Plast & Hand Surg, Univ Hosp Erlangen, Erlangen, Germany.
EM ingo.ludolph@uk-erlangen.de
RI Horch, Raymund/H-8128-2019
FU Baxter AG Vienna; KCI-Acelity, Wiesbaden, Germany
FX Another author has received grants for scientific studies from
   KCI-Acelity, Wiesbaden, Germany and Baxter AG Vienna, and has acted as a
   lecturer and as an advisor for KCI-Acelity Wiesbaden and San Antonio,
   and has acted as an invited speaker for Novadaq, Germany.
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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NR 37
TC 25
Z9 28
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2019
VL 72
IS 2
BP 139
EP 150
DI 10.3233/CH-180450
PG 12
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA IO3VW
UT WOS:000479309800004
PM 30664503
DA 2026-07-24
ER

PT J
AU Kapusta, P
   Konieczny, PS
   Hohendorff, J
   Borys, S
   Toton-Zuranska, J
   Kiec-Wilk, BM
   Wolkow, PP
   Malecki, MT
AF Kapusta, Przemyslaw
   Konieczny, Pawel S.
   Hohendorff, Jerzy
   Borys, Sebastian
   Toton-Zuranska, Justyna
   Kiec-Wilk, Beata M.
   Wolkow, Pawel P.
   Malecki, Maciej T.
TI Negative pressure wound therapy affects circulating plasma microRNAs in
   patients with diabetic foot ulceration
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Diabetic foot syndrome; Diabetic foot ulceration; Negative-Pressure
   Wound Therapy (NPWT); Type 2 Diabetes (T2DM); Plasma microRNA-seq
ID DIFFERENTIAL EXPRESSION ANALYSIS; MANAGEMENT; DIAGNOSIS; MELLITUS; GENES
AB Aims: Negative pressure wound therapy (NPWT) is commonly used in diabetic foot ulceration (DFU). The molecular mechanisms of NPWT action, particularly outside of the wound site, have not been described. We assessed NPWT's effect on circulating miRNA expression levels in type 2 diabetes (T2DM) patients with DFU.
   Methods: We examined 34 T2DM patients treated with either NPWT (n = 24) or standard therapy (ST, n = 10). The group assignment was based on clinical criteria and local practice. Next-generation sequencing-based microRNA expression was determined on the patient's plasma collected before therapy and after 8 days.
   Results: NPWT patients were similar to the ST group in terms of age, BMI, and HbA1c level; however, they differed by mean wound area (12.6 cm(2) vs. 1.1 cm(2) p = 0.0005). First, we analyzed the change of miRNA after NPWT or ST and observed an upregulation of let-7f-2 only in the NPWT group. Then, we analyzed the differential expression between NPWT and ST groups, looking at possible wound size effects. We found 12 differentially expressed miRNAs in pre-treatment comparison, including let-7f-2, while in post-treatment analysis we identified 28 miRNAs. The pathway enrichment analysis suggests that identified miRNAs may be involved in wound healing, particularly through angiogenesis.
   Conclusion: We found initial evidence that NPWT in T2DM patients with DFU affects miRNA expression in plasma. Additionally, some differences in plasma miRNA expression may be related to wound size. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Kapusta, Przemyslaw; Konieczny, Pawel S.; Toton-Zuranska, Justyna; Wolkow, Pawel P.] Jagiellonian Univ, Coll Med, Ctr Med Genom OMICRON, 7 Kopernika St, PL-31034 Krakow, Poland.
   [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata M.; Malecki, Maciej T.] Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.
   [Hohendorff, Jerzy; Borys, Sebastian; Kiec-Wilk, Beata M.; Malecki, Maciej T.] Univ Hosp, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wolkow, PP (通讯作者)，Jagiellonian Univ, Coll Med, Ctr Med Genom OMICRON, 7 Kopernika St, PL-31034 Krakow, Poland.; Malecki, MT (通讯作者)，Jagiellonian Univ, Coll Med, Dept Metab Dis, 15 Kopernika St, PL-31501 Krakow, Poland.
EM pawel.wolkow@uj.edu.pl; pawel.wolkow@uj.edu.pl; maciej.malecki@uj.edu.pl
RI Wolkow, Pawel/AAI-4222-2021; Hohendorff, Jerzy/U-1857-2018; Konieczny,
   Pawel/D-7537-2017; Totoń-Żurańska, Justyna/AAM-9149-2021
OI Hohendorff, Jerzy/0000-0003-1153-8669; Konieczny,
   Pawel/0000-0002-6173-3836; Totoń-Żurańska, Justyna/0000-0001-5970-238X
FU National Science Centre in Poland [2013/11/B/NZ5/03298]
FX YThe study was funded by the National Science Centre in Poland through
   the Opus Grant ''Assessment of molecular mechanisms of negative
   pressurewound therapy in the treatment of neuropathic ulceration in
   diabetic foot syndrome"to MTM (Nr 2013/11/B/NZ5/03298).
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NR 45
TC 12
Z9 14
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUL
PY 2020
VL 165
AR 108251
DI 10.1016/j.diabres.2020.108251
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MT4EL
UT WOS:000554922700028
PM 32531327
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Chong, SJ
   Tan, MK
   Liang, WH
   Kim, SJ
   Soh, CR
AF Chong, Si Jack
   Tan, Meng Kwan
   Liang, Weihao
   Kim, Soo Joang
   Soh, Chai Rick
TI Maintenance of negative-pressure wound therapy while undergoing
   hyperbaric oxygen therapy
SO DIVING AND HYPERBARIC MEDICINE
LA English
DT Article
DE Wounds; hyperbaric oxygen; treatment; equipment; safety
AB (Chong SI, Tan MK, Liang W, Kim SJ, Soh CR. Maintenance of negative-pressure wound therapy while undergoing hyperbaric oxygen therapy. Diving Hyperb Med. 2011;41(3):147-50.)
   Background: Both negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) are useful modalities in the treatment of problem wounds. However, none of the commercially available portable negative-pressure devices have been certified safe for use in a recompression chamber. Thus, the NPWT device is removed while the patient undergoes HBOT. The purpose of this study is to demonstrate that wound negative pressure can be effectively and safely maintained during HBOT.
   Patients and methods: In a small, prospective, randomised crossover trial, we used commonly available clinical materials to connect the NPWT suction tubing to the negative suction generating device in the hyperbaric chamber. Six patients each underwent one HBOT session with continuous NPWT and one HBOT session without concurrent NPWT. We assessed the patient's pain score, the amount of exudate aspirated by the NPWT during HBOT, and the appearance of the wound dressing after each session was assessed in a blinded manner.
   Results: There were no differences in pain scores between the two HBOT sessions. The amount of exudate aspirated during HBOT with NPWT ranged from 5 to 12 ml. Five of the six patients has a better appearance scoring of their dressing when NPWT was maintained during HBOT (P = 0.006).
   Conclusion: We successfully demonstrated a simple design that allows the maintenance of NPWT during HBOT without causing additional pain, and with continued extraction of exudate. The maintenance of NPWT during HBOT also allowed the dressing to be maintained undisturbed.
C1 [Chong, Si Jack] Republ Singapore Navy, Navy Med Serv, Singapore 498822, Singapore.
   [Chong, Si Jack; Liang, Weihao] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 0316, Singapore.
   [Tan, Meng Kwan; Kim, Soo Joang] Singapore Gen Hosp, Hyperbar & Diving Med Ctr, Singapore 0316, Singapore.
   [Soh, Chai Rick] Singapore Gen Hosp, Dept Anaesthesiol, Singapore 0316, Singapore.
C3 Singapore General Hospital; Singapore General Hospital; Singapore
   General Hospital
RP Chong, SJ (通讯作者)，Republ Singapore Navy, Navy Med Serv, 126 Tanah Merah Coast Rd, Singapore 498822, Singapore.
EM chong_si_jack@hotmail.com
CR [Anonymous], 2008, HYP OX THER IND
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Clark L A, 1999, Respir Care Clin N Am, V5, P203
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NR 9
TC 6
Z9 9
U1 0
U2 10
PU SOUTH PACIFIC UNDERWATER MED SOC
PI MELBOURNE
PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD,
   MELBOURNE, VIC 3004, AUSTRALIA
SN 1833-3516
J9 DIVING HYPERB MED
JI Diving Hyperb. Med.
PD SEP
PY 2011
VL 41
IS 3
BP 147
EP 150
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 825GF
UT WOS:000295258500009
PM 21948500
DA 2026-07-24
ER

PT J
AU Huang, HP
   Zhao, WJ
   Pu, J
   He, F
AF Huang, Hua-Ping
   Zhao, Wen-Jun
   Pu, Jia
   He, Fang
TI Prophylactic negative pressure wound therapy for surgical site infection
   in obese women undergoing cesarean section: an evidence synthesis with
   trial sequential analysis*
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Cesarean section; complication; negative pressure wound therapy; obese
ID DELIVERY; COMPLICATIONS; PREVENTION; MANAGEMENT; RISK
AB Objective: Current evidence for negative pressure wound therapy (NPWT) on surgical site infection (SSI) and wound complications in cesarean section is conflicting. The objective of this study was to evaluate the efficacy of prophylactic NPWT for preventing SSI and other wound complications in obese women undergoing cesarean section (CS). Methods: We systematically searched PubMed, Embase, the Cochrane Library and clinicaltTrial.gov to identify randomized controlled trials (RCTs) that compared NPWT with standard dressing for cesarean section. The primary outcome was SSI. Secondary outcomes were overall wound complications and hospital readmission. Risk ratio (RR) with 95% confidence intervals (CIs) was calculated using random-effects models. Review Manager 5.3 was applied to analyze the collected data. Results: Eight RCTs involving 1972 patients were included in this meta-analysis. The pooled results showed that the risk of SSI was significantly lower with the use of NPWT when compared with standard dressing (RR = 0.68, 95%CI = 0.51-0.90, p = .008). However, there was no difference in overall wound complications (RR = 0.93, 95%CI = 0.74-1.17, p = 0.52) and hospital readmission (RR = 1.03, 95%CI = 0.67-1.60, p = .89) between two groups. Current evidence was not confirmed by trial sequential analysis. Conclusion: On the basis of our findings, NPWT decreases the risk of SSI after cesarean section in obese women after CS, despite this approach does not reduce the overall wound complications and hospital readmission. However, further RCTs are needed to make conclusive evidence.
C1 [Huang, Hua-Ping; Zhao, Wen-Jun] Mianyang Cent Hosp, Dept Operat Room, Mianyang, Sichuan, Peoples R China.
   [Pu, Jia] North Sichuan Med Coll, Dept Nursing, Nanchang, Jiangxi, Peoples R China.
   [He, Fang] Mianyang Cent Hosp, Dept Nursing Adm, Mianyang, Sichuan, Peoples R China.
C3 North Sichuan Medical University
RP Huang, HP (通讯作者)，Mianyang Cent Hosp, Dept Operat Room, 12 Changjia Alley,Jingzhong St, Mianyang, Fucheng Distric, Peoples R China.
EM jrzhou26@aliyun.com
RI Huang, Huaping/G-5523-2016; Pu, Jiamin/KTH-7490-2024
OI Huang, Huaping/0000-0002-0534-2718; 
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NR 27
TC 16
Z9 18
U1 2
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD AUG 3
PY 2021
VL 34
IS 15
BP 2498
EP 2505
DI 10.1080/14767058.2019.1668924
EA SEP 2019
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SO9PO
UT WOS:000489480800001
PM 31530067
DA 2026-07-24
ER

PT J
AU Zhang, D
   Li, ZH
   Wang, Z
   Zeng, FW
   Xiao, WD
   Yu, AX
AF Zhang, Dong
   Li, Zonghuan
   Wang, Zheng
   Zeng, Fanwei
   Xiao, Weidong
   Yu, Aixi
TI MicroRNA-126: a promising biomarker for angiogenesis of diabetic wounds
   treated with negative pressure wound therapy
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE microRNA-126; negative-pressure wound therapy; diabetic wound healing
ID ENDOTHELIAL GROWTH-FACTOR; DOWN-REGULATION; INFLAMMATION; COMPLICATIONS;
   EXPRESSION; IMPAIRS; BLOOD
AB Background: Negative pressure wound therapy represents an effective therapy to treat nonhealing diabetic wounds by promoting angiogenesis, of which the mechanism hasn't been investigated thoroughly. Growing evidence suggests that miRNAs hold great potential to be clinical biomarkers, and miR-126 is an essential angiogenesis regulator in diabetic wound repair.
   Purpose: Our study aims to explore the effect of NPWT on the expression of miR-126 in the wound tissue and plasma of diabetic rat models and the association between circulating miR-126 and two quantitative indexes of angiogenesis.
   Methods: Full-thickness excisional wounds were created on the back of diabetic rats. Measure the wound closure and collect the wound tissue and blood for H&E, immunohistochemistry, Western blot and RT-PCR. Here we demonstrated that significantly increased capillary density and arteriolar density in the NPWT group at each specified time-point.
   Results: In the NPWT group, miR-126 expression was significantly increased on days 3, 5, 7, and 9 (P<0.05). Furthermore, statistically significant increases in VEGF mRNA and protein expression and p-ERK expression, as well as decreased SPRED1 expression, were noted upon treatment with NPWT on day 9. Our data revealed that miR-126 expression in the wound and plasma was significantly associated (P<0.05). Moreover, a positive correlation was also detected between increased levels of circulating miR-126 and arteriolar density, as well as capillary density (P<0.05).
   Conclusion: The study suggested that miR-126 was upregulated by NPWT and could represent a promising monitoring tool for angiogenesis in diabetic wounds treated with NPWT.
C1 [Zhang, Dong; Li, Zonghuan; Wang, Zheng; Zeng, Fanwei; Xiao, Weidong; Yu, Aixi] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Xiao, WD; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM 1539562641@qq.com; yuaixi@whu.edu.cn
RI Wang, Zheng/KLC-2372-2024; Zeng, Fanwei/LTY-9303-2024
OI Wang, Zheng/0000-0002-1176-7659; 
FU Independent Research Project of Wuhan University [2042017kf0079]
FX The authors would like to acknowledge the Wuhan VSD Medical Science &
   Technology, Co., Ltd. (Wuhan, China) for supplying the vacuum material.
   This work was supported by Grants from the Independent Research Project
   of Wuhan University (Grant no. 2042017kf0079).
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NR 42
TC 26
Z9 31
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1685
EP 1696
DI 10.2147/DMSO.S199705
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IU3PU
UT WOS:000483499700001
PM 31564936
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhao, JC
   Shi, K
   Zhang, N
   Hong, L
   Yu, JA
AF Zhao, Jingchun
   Shi, Kai
   Zhang, Nan
   Hong, Lei
   Yu, Jiaao
TI Assessment between antiseptic and normal saline for negative pressure
   wound therapy with instillation and dwell time in diabetic foot
   infections
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Diabetic foot infection; PHMB; Negative pressure wound therapy;
   Instillation and dwell time
ID ANTIMICROBIAL SOLUTIONS; CLEANSING SOLUTION; BETAINE SOLUTION; BED
   PREPARATION; POLYHEXANIDE; BIOFILM; MANAGEMENT; IMPACT; RISK; GEL
AB Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is increasingly used for a diverse range of wounds. Meanwhile, the topical wound irrigation solution consisting of polyhexamethylene biguanide and betaine (PHMB-B) has shown efficacy in managing wound infections. However, the effectiveness of this solution as a topical instillation solution for NPWTi-d in patients with diabetic foot infections (DFIs) has not been thoroughly studied. The objective of this retrospective study was to evaluate the impact of using PHMB-B as the instillation solution during NPWTi-d on reducing bioburden and improving clinical outcomes in patients with DFIs. Between January 2017 and December 2022, a series of patients with DFIs received treatment with NPWTi-d, using either PHMB-B or normal saline as the instillation solution. Data collected retrospectively included demographic information, baseline wound characteristics, and treatment outcomes. The study included 61 patients in the PHMB-B group and 73 patients in the normal saline group, all diagnosed with DFIs. In comparison to patients treated with normal saline, patients with PHMB-B exhibited no significant differences in terms of wound bed preparation time (P = 0.5034), length of hospital stay (P = 0.6783), NPWTi-d application times (P = 0.1458), duration of systematic antimicrobial administration (P = 0.3567), or overall cost of hospitalization (P = 0.6713). The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.
C1 [Zhao, Jingchun; Shi, Kai; Zhang, Nan; Hong, Lei; Yu, Jiaao] First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
C3 Jilin University
RP Yu, JA (通讯作者)，First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
EM yuja@jlu.edu.cn
RI Zhang, Nan/B-2532-2016
FU National Key Research and Development Program of China [2021YFF1201200];
   Health Science and Technology Ability Improvement Project of Jilin
   Province [2023LC004]
FX This work received grants from the National Key Research and Development
   Program of China (2021YFF1201200), the Health Science and Technology
   Ability Improvement Project of Jilin Province (2023LC004).
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NR 43
TC 10
Z9 11
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 19
PY 2024
VL 14
IS 1
AR 11423
DI 10.1038/s41598-024-58900-3
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RK8D7
UT WOS:001227641500008
PM 38763922
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Seaman, AP
   Sarac, BA
   ElHawary, H
   Janis, JE
AF Seaman, A. P.
   Sarac, B. A.
   ElHawary, H.
   Janis, J. E.
TI The effect of negative pressure wound therapy on surgical site
   occurrences in closed incision abdominal wall reconstructions: a
   retrospective single surgeon and institution study
SO HERNIA
LA English
DT Article
DE Closed incision negative pressure wound therapy
ID MANAGEMENT; EVENTS; REPAIR
AB Purpose The use of closed incision negative pressure wound therapy (ciNPWT) in abdominal wall reconstruction is heavily debated. The current literature shows mixed results for its efficacy in preventing surgical site occurrences (SSOs), and many of the studies are limited by small sample size or a lack of generalizability. We sought to assess whether the use of prophylactic ciNPWT has an effect on reducing the rate of SSOs. Methods Following institutional review board approval, a retrospective analysis of a prospectively collected abdominal wall reconstruction database of a single surgeon at a single institution was completed. Two hundred and seventy patients were reviewed. Univariate and multivariate logistic regressions were performed to assess the effect of each variable on the rate of SSOs. Results Two hundred and fifty-eight patients (95.56%) met inclusion criteria. One hundred and fifty-nine (61.63%) of these patients received ciNPWT. The median duration of ciNPWT was 6 days. Multivariate logistic regression analysis showed no significant difference in the prevalence of SSOs between groups (OR = 0.843, 95% CI [0.445-1.594], p = 0.598). It did, however, show a significant decrease in the rates of seroma (7.07% vs. 0.63%, p = 0.004). Moreover, skin resection was associated with a decreased rate of SSO (OR = 0.295, 95% CI [0.096-0.911], p = 0.034). Conclusions ciNPWT was not associated with a decrease in SSOs following abdominal wall reconstruction but did show a statistically significant decrease in postoperative seromas. Future, large prospective analyses may help further discover the utility of ciNPWT in reducing SSOs.
C1 [Seaman, A. P.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
   [ElHawary, H.] McGill Univ, Div Plast & Reconstruct Surg, Montreal, PQ, Canada.
   [Sarac, B. A.; Janis, J. E.] Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
C3 University System of Ohio; Ohio State University; McGill University;
   University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
EM Jeffrey.janis@osumc.edu
RI Janis, Jeffrey/W-6760-2019
OI Janis, Jeffrey/0000-0001-6103-4798; Seaman, Austin/0000-0002-3454-268X;
   Sarac, Benjamin/0000-0001-7825-4957; ElHawary,
   Hassan/0000-0003-4542-5814
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NR 30
TC 9
Z9 11
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD DEC
PY 2021
VL 25
IS 6
BP 1549
EP 1555
DI 10.1007/s10029-021-02427-3
EA MAY 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XC8RX
UT WOS:000652093500002
PM 34009506
DA 2026-07-24
ER

PT J
AU Nease, C
AF Nease, Cheryl
TI Using Low Pressure, Negative Pressure Wound Therapy for Wound
   Preparation and the Management of Split-Thickness Skin Grafts in Three
   Patients with Complex Wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case series; traumatic wounds; skin grafts; low-pressure negative
   pressure therapy
AB The use of negative pressure wound therapy (NPWT) is well established in the management of hard-to-heal wounds. One institution, familiar with NPWT's capabilities as well as its shortcomings (eg,. pain at dressing changes and pain with the maximum recommended setting of 125 mm Hg), sought a viable alternative. A low pressure, negative pressure wound therapy (LP-NPWT) system, using subatmospheric pressure levels of 75 mm Hg and a low-adherence dressing, was evaluated to prepare the wound bed for split-thickness skin graft (STSG) on three patients. One patient was a healthy 23-year-old man with extensive trauma-related soft tissue wounds. The two women - 54 and 47 years old - had multiple comorbidities. One had a lower extremity fasciotomy wound and the other had a dehisced surgical wound with a history of irradiation. Wound area was reduced >60% in all three wounds in 3 to 6 weeks as new granulation tissue developed. The average pain reported was moderate (4 to 5 on a Visual Analogue Scale), ranging from 2 to 10 during dressing changes to 1 to 7 between dressing changes; pain levels reported tended to decrease as therapy progressed. Little or no trauma on dressing removal and no signs of infection were noted. In all cases, STSGs, followed by 4 days of LP-NPWT were applied and all wounds healed. The results from these three cases suggest that the LP-NPWT system is a useful healing adjunct for complex wound bed preparation and graft management. Clinical studies to quantify the effects of LP-NPWT technology and compare its safety and efficacy to other negative pressure systems are needed.
C1 Mem Hlth Univ, Med Ctr, Savannah, GA 31403 USA.
RP Nease, C (通讯作者)，Mem Hlth Univ, Med Ctr, 4700 Waters Ave, Savannah, GA 31403 USA.
EM cnease1987@aol.com
CR Andros G, 2006, WOUNDS, P1
   CAMPBELL P, 2006, J WOCN, V33, P2
   COUPER SG, 2008, 21 ANN S ADV WOUND C
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NR 15
TC 21
Z9 23
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2009
VL 55
IS 6
BP 32
EP 42
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 463BZ
UT WOS:000267404700007
PM 19564671
DA 2026-07-24
ER

PT J
AU Prete, F
   De Luca, GM
   Pasculli, A
   Di Meo, G
   Poli, E
   Sgaramella, LI
   Panzera, P
   Vittore, F
   Filoia, A
   Catena, F
   Testini, M
   Gurrado, A
AF Prete, Francesco
   De Luca, Giuseppe Massimiliano
   Pasculli, Alessandro
   Di Meo, Giovanna
   Poli, Elisabetta
   Sgaramella, Lucia Ilaria
   Panzera, Piercarmine
   Vittore, Francesco
   Filoia, Antonella
   Catena, Fausto
   Testini, Mario
   Gurrado, Angela
TI Retrospective Study of Indications and Outcomes of Open Abdomen with
   Negative Pressure Wound Therapy Technique for Abdominal Sepsis in a
   Tertiary Referral Centre
SO ANTIBIOTICS-BASEL
LA English
DT Article
DE abdominal sepsis; open abdomen; damage control surgery; negative
   pressure wound therapy; acute care surgery
ID MEDIATED FASCIAL TRACTION; DAMAGE-CONTROL; CLOSURE; MANAGEMENT; VACUUM;
   CLASSIFICATION; METAANALYSIS; SURGERY
AB In patients with advanced sepsis from abdominal disease, the open abdomen (OA) technique as part of a damage control surgery (DCS) approach enables relook surgery to control infection, defer intestinal anastomosis, and prevent intra-abdominal hypertension. Limited evidence is available on key outcomes, such as mortality and rate of definitive fascial closure (DFC), which are needed for surgeons to select patients and adequate therapeutic strategies. Abdominal closure with negative pressure wound therapy (NPWT) has shown rates of DFC around 90%. We conducted a retrospective study to evaluate in-hospital survival and factors associated with mortality in acute, non-trauma patients treated using the OA technique and NPWT for sepsis from abdominal disease. Fifty consecutive patients treated using the OA technique and NPWT between February 2015 and July 2022 were included. Overall mortality was 32%. Among surviving patients, 97.7% of cases reached DFC, and the overall complication rate was 58.8%, with one case of entero-atmospheric fistula. At univariable analysis, age (p = 0.009), ASA IV status (<0.001), Mannheim Peritonitis Index > 30 (p = 0.001) and APACHE II score (p < 0.001) were associated with increased mortality. At multivariable analysis, higher APACHE II was a predictor of in-hospital mortality (OR 2.136, 95% CI 1.08-4.22; p = 0.029). Although very resource-intensive, DCS and the OA technique are valuable tools to manage patients with advanced abdominal sepsis, allowing reduced mortality and high DFC rates.
C1 [Prete, Francesco; De Luca, Giuseppe Massimiliano; Pasculli, Alessandro; Di Meo, Giovanna; Poli, Elisabetta; Sgaramella, Lucia Ilaria; Panzera, Piercarmine; Vittore, Francesco; Filoia, Antonella; Testini, Mario; Gurrado, Angela] Univ Bari Aldo Moro, Med Sch, Acad Gen Surg Unit, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
   [Catena, Fausto] Maggiore Hosp Parma, Emergency & Trauma Surg Dept, I-43126 Parma, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Prete, F (通讯作者)，Univ Bari Aldo Moro, Med Sch, Acad Gen Surg Unit, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
EM francesco.prete@uniba.it
RI ; Sgaramella, Lucia Ilaria/LMQ-3099-2024; Gurrado, Angela/HZM-4980-2023;
   Prete, Francesco/J-7141-2019; Panzera, Piercarmine/HOC-2022-2023;
   Pasculli, Alessano/M-4541-2018; Di Meo, Giovanna/JRR-9074-2023
OI Testini, Mario/0000-0002-9297-4894; Sgaramella, Lucia
   Ilaria/0000-0002-6087-4119; Gurrado, Angela/0000-0002-2009-5831; Prete,
   Francesco/0000-0003-0426-8752; Panzera, Piercarmine/0000-0002-5231-8550;
   Pasculli, Alessano/0000-0003-2276-2383; Di Meo,
   Giovanna/0000-0002-7012-8654
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NR 35
TC 5
Z9 9
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2079-6382
J9 ANTIBIOTICS-BASEL
JI Antibiotics-Basel
PD NOV
PY 2022
VL 11
IS 11
AR 1498
DI 10.3390/antibiotics11111498
PG 10
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 6A5FR
UT WOS:000880681900001
PM 36358153
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hourigan, LA
   Omaye, ST
   Keen, CL
   Jones, JA
   Dubick, MA
AF Hourigan, Leslie A.
   Omaye, Stanley T.
   Keen, Carl L.
   Jones, John A.
   Dubick, Michael A.
TI Vitamin and Trace Element Loss from Negative-Pressure Wound Therapy
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE wound exudate; micronutrients; vitamins; minerals; negative pressure
   wound therapy
ID RETINOL-BINDING-PROTEIN; SURROGATE MEASURE; CRITICALLY-ILL;
   SUPPLEMENTATION; COPPER
AB OBJECTIVE: This study investigated select vitamin and trace element loss from wound exudates in burn and trauma patients treated with negative-pressure wound therapy (NPWT).
   DESIGN: A prospective observational study was performed using wound exudate samples.
   SETTING: A level I trauma center acute care hospital.
   PARTICIPANTS: The study was composed of 8 patients with open abdomens and 9 patients with 12 soft-tissue wounds.
   MAIN OUTCOME MEASURES: The goal was to collect wound exudate samples daily for 3 days, then every other day to day 9 or until NPWT was discontinued, and to analyze for vitamins A (retinol), C, and E and zinc (Zn), iron (Fe), and copper (Cu). Daily loss of each micronutrient was calculated from their concentration and 24-hour volumes of the exudates.
   MAIN RESULTS: Exudate loss in the open-abdomen group was significantly higher than in the patients with soft-tissue wounds (900 547 vs 359 +/- 246 mL/d). The mean 24-hour loss of vitamins A, C, and E were 0.3, 2.8, and 11 mg, respectively, in the open-abdomen group. Over the same period, the losses of Zn, Fe, and Cu were 0.5, 0.4, and 0.25 mg, respectively, in these patients. Micronutrient 24-hour loss was significantly lower in the soft-tissue wound patients than in the open-abdomen group.
   CONCLUSIONS: The data support the concept that significant amounts of micronutrients can be lost from NPWT wound exudates, particularly in open abdomens. These losses should be considered in the nutritional support of these patients who typically are in a hypermetabolic and catabolic state.
C1 [Hourigan, Leslie A.] Brooke Army Med Ctr, San Antonio, TX 78234 USA.
   [Omaye, Stanley T.] Univ Nevada, Dept Agr Nutr & Vet Sci, Reno, NV 89557 USA.
   [Keen, Carl L.] Univ Calif Davis, Nutr & Internal Med, Davis, CA 95616 USA.
   [Jones, John A.] US Army Inst Surg Res, San Antonio, TX USA.
   [Dubick, Michael A.] US Army Inst Surg Res, DCR Res Program, San Antonio, TX USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center; Nevada System of Higher Education (NSHE); University of
   Nevada Reno; University of California System; University of California
   Davis; United States Department of Defense; United States Army; United
   States Department of Defense; United States Army
RP Hourigan, LA (通讯作者)，Brooke Army Med Ctr, San Antonio, TX 78234 USA.
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NR 32
TC 4
Z9 5
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2016
VL 29
IS 1
BP 20
EP 25
DI 10.1097/01.ASW.0000473680.06666.6a
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA CZ2LP
UT WOS:000366937000004
PM 26650093
DA 2026-07-24
ER

PT J
AU Wade, C
   Wolf, SE
   Salinas, R
   Jones, JA
   Rivera, R
   Hourigan, L
   Baskin, T
   Linfoot, J
   Mann, EA
   Chung, K
   Dubick, M
AF Wade, Charles
   Wolf, Steven E.
   Salinas, Reuben
   Jones, John A.
   Rivera, Racheal
   Hourigan, Leslie
   Baskin, Toney
   Linfoot, John
   Mann, Elizabeth A.
   Chung, Kevin
   Dubick, Michael
TI Loss of Protein, Immunoglobulins, and Electrolytes in Exudates From
   Negative Pressure Wound Therapy
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE negative-pressure wound therapy; wounds and injuries; exudates and
   transudates; carrier proteins, nutrition requirements, nitrogen
ID NUTRITIONAL SUPPORT; ENTERAL NUTRITION; GUIDELINES
AB Background: A relatively new technology in wound care, negative pressure wound therapy (NPWT), has become widely used for the management of open abdomens and soft tissue wounds and provides a means to collect wound exudate to quantify protein loss.
   Methods: A prospective observational study was conducted in surgical, trauma, or burn patients (8 patients with open abdomens and 9 patients with acute soft tissue wounds on NPWT). NPWT exudate was collected and assayed to characterize loss of protein, electrolyte, and immunoglobulins over multiple days of NPWT.
   Results: Total protein was present in open abdomen NPWT exudate, 2.9 +/- 0.9 g/dL. In the soft tissue wound exudate, a similar mean concentration was found, 2.59 +/- 0.6 g/dL (P = .34). Exudate concentrations of albumin, urea nitrogen, immunoglobulins, and electrolytes between wound types were also not significantly different. There were significant (P = .03) differences in the median volume of exudate, 1031 mL/d for open abdomens in contrast to 245 mL/d soft tissue wounds. Therefore, 24-hour losses of proteins and electrolytes were greater in patients with open abdomens than soft tissue wounds. Mean total protein loss was 25 +/- 17 g/d for open abdomens and 8 +/- 5 g/d for soft tissue wounds.
   Conclusion: There are significant losses of proteins in wound exudate. As there is no significant difference in the concentration of total protein between wound type, the rate of loss may be calculated as 2.9 g/dL times the volume of wound exudate. The rate of protein loss from wounds is similar to the presently assumed insensible loss rate of 12-25 g/d.(Nutr Clin Pract. 2010; 25:510-516)
C1 [Hourigan, Leslie] Dept 3851, Ft Sam Houston, TX 78234 USA.
RP Hourigan, L (通讯作者)，Dept 3851, Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM leslie.houri-gan@us.army.mil
OI Wolf, Steven/0000-0003-2972-3440
FU DOD-Department of the Army
FX Dr. Wade was supported by DOD-Department of the Army.
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NR 24
TC 49
Z9 54
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD OCT
PY 2010
VL 25
IS 5
BP 510
EP 516
DI 10.1177/0884533610379852
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 688JB
UT WOS:000284844500010
PM 20962311
OA Bronze
DA 2026-07-24
ER

PT J
AU Yoshida, S
   Ishida, O
   Tsutsumi, K
AF Yoshida, S.
   Ishida, O.
   Tsutsumi, K.
TI Prophylactic closed-incision negative pressure wound therapy after
   median sternotomy: a scoping review of surgical site infection
   prevention bundle reporting and implication for interpretation
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Review
DE Cardiac surgical procedures; Negative pressure wound therapy;
   Postoperative complications; Surgical site infection; Wound healing
ID MANAGEMENT-SYSTEM; ASSOCIATION; STATEMENT
AB Background: Closed-incision negative pressure wound therapy (ciNPT) is increasingly used to reduce surgical site infection (SSI) after median sternotomy, yet its true preventive effect remains uncertain. Published studies rarely specify which infection prevention measures were used alongside the therapy, making interpretation difficult. Aim: In this scoping review, we examined the completeness of reporting of infection prevention practices in studies evaluating ciNPT after cardiac surgery. Methods: A systematic search of PubMed, Scopus, and the Cochrane Library identified studies of adult cardiac surgery in which negative pressure therapy was applied prophylactically to the closed sternal incision. Information on study design, patient characteristics, therapy protocols, clinical outcomes, and reporting of infection prevention elements was extracted. Reporting was classified as complete, partial, or absent according to 13 components derived from major clinical guidelines. Findings: Twenty-five studies met the inclusion criteria. Most studies reported fewer SSIs in patients receiving negative pressure therapy, but none described a complete set of infection prevention measures. Eighty-seven percent of recommended elements were not reported, and selective use of the therapy introduced additional bias. Conclusion: The substantial absence of infection prevention reporting limits the interpretability and reproducibility of current evidence. Standardized and transparent documentation is required to better define the preventive value of ciNPT. (c) 2026 The Author(s). Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Yoshida, S.; Ishida, O.; Tsutsumi, K.] Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan
RP Ishida, O (通讯作者)，Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM oishida2000@gmail.com
RI Ishida, Osamu/GRJ-5887-2022
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD JUL
PY 2026
VL 173
BP 230
EP 239
DI 10.1016/j.jhin.2026.05.020
EA JUN 2026
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA JU3NB
UT WOS:001798164700001
PM 42167605
OA hybrid
DA 2026-07-24
ER

PT J
AU Brewer, CF
   Manan, Z
   Miranda, BH
AF Brewer, Christopher F.
   Manan, Zaki
   Miranda, Benjamin H.
TI Incisional negative pressure wound therapy following abdominoplasty and
   abdominal free flap surgery: a meta-analysis of outcomes and review of
   costs
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE abdominoplasty; abdominal free flap; complications; cost; dehiscence;
   incisional negative pressure wound therapy; negative pressure; surgical
   site wound complications; wound; wound care; wound dressing; wound
   healing
ID SURGICAL SITE INFECTION; DONOR-SITE; BREAST RECONSTRUCTION; RISK;
   COMPLICATIONS; DEHISCENCE; EFFICACY
AB Objective: Incisional negative pressure wound therapy (iNPWT) is purported to enhance wound healing and reduce the incidence of surgical site wound complications (SSWCs). This systematic review and meta-analysis aimed to evaluate the efficacy and associated costs of iNPWT for abdominoplasty or abdominal free flap donor site surgeries. Method: A literature review was undertaken for studies relating to iNPWT and SSWCs following abdominoplasty or abdominal free flap procedures. Results: After applying the exclusion criteria, 12 studies were identified, incorporating 517 and 589 patients in the iNPWT and control groups, respectively. Pooled analysis identified a significant reduction in the incidence of wound dehiscence in the iNPWT group compared with the control arm (11.7% versus 20.2%, respectively; p<0.05), with meta-analysis demonstrating a relative risk (RR) of 0.60 in the iNPWT group versus controls (RR: 0.60, 95% confidence interval: 0.42-0.87, I2=0%; p=0.85). Incidence of all other SSWCs was comparable between both groups. The two studies which reported associated healthcare costs found iNPWT to be comparable with standard of care. Conclusion: This systematic review and meta-analysis provides evidence to support the judicious use of iNPWT to reduce wound dehiscence in high-risk abdominoplasty and abdominal free flap donor site surgeries. The evidence for reduction of other SSWCs is lacking, and any effect is likely to be minimal. Heterogeneity and poor study design limit the strength of these quantitative findings, and higher quality randomised controlled trials are required in this area.
C1 [Brewer, Christopher F.] Addenbrookes Hosp, Dept Plast Surg, Cambridge, England.
   [Manan, Zaki; Miranda, Benjamin H.] St Andrews Ctr Plast Surg & Burns, St Andrews Anglia Ruskin StAAR Res Grp, Cambridge, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Miranda, BH (通讯作者)，St Andrews Ctr Plast Surg & Burns, St Andrews Anglia Ruskin StAAR Res Grp, Cambridge, England.
EM ben.miranda@nhs.net
RI /AAV-3434-2020; Brewer, Christopher/NZO-1408-2025
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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   Saunders C, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zraa003
   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
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   Wong M, 2020, Incisional negative pressure wound therapy in high risk patients undergoing panniculectomy: a prospective randomized controlled trial
   Xie WW, 2022, INT WOUND J, V19, P1319, DOI 10.1111/iwj.13726
   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 34
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2025
VL 34
IS 4
BP 286
EP 293
DI 10.12968/jowc.2023.0113
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1SQ3W
UT WOS:001472700300005
PM 40227922
DA 2026-07-24
ER

PT J
AU Larson, BJ
   Roakes, A
   Yurick, S
   Netravali, NA
AF Larson, Barrett J.
   Roakes, Ashley
   Yurick, Steve
   Netravali, Nathan A.
TI Precision in Prevention: Tailoring Single-Use Negative Pressure Wound
   Therapy Utilization Through Artificial Intelligence-Based Surgical Site
   Complications Risk and Cost Modeling
SO SURGICAL INFECTIONS
LA English
DT Article
DE closed surgical incisions; single-use negative pressure wound therapy;
   NPWT; surgical site complications; machine learning; risk prediction
ID CLINICAL REGISTRY; CLAIMS DATA; INFECTIONS; DRESSINGS; CONSEQUENCES;
   IMPACT
AB Background: Surgical site complications (SSCs) are common, yet preventable hospital-acquired conditions. Single-use negative pressure wound therapy (sNPWT) has been shown to be effective in reducing rates of these complications. In the era of value-based care, strategic allocation of sNPWT is needed to optimize both clinical and financial outcomes.Materials and Methods: We conducted a retrospective analysis using data from the Premier Healthcare Database (2017-2021) for 10 representative open procedures in orthopedic, abdominal, cardiovascular, cesarean delivery, and breast surgery. After separating data into training and validation sets, various machine learning algorithms were used to develop pre-operative SSC risk prediction models. Model performance was assessed using standard metrics and predictors of SSCs were identified through feature importance evaluation. Highest-performing models were used to simulate the cost-effectiveness of sNPWT at both the patient and population level.Results: The prediction models demonstrated good performance, with an average area under the curve of 76%. Prominent predictors across subspecialities included age, obesity, and the level of procedure urgency. Prediction models enabled a simulation analysis to assess the population-level cost-effectiveness of sNPWT, incorporating patient and surgery-specific factors, along with the established efficacy of sNPWT for each surgical procedure. The simulation models uncovered significant variability in sNPWT's cost-effectiveness across different procedural categories.Conclusions: This study demonstrates that machine learning models can effectively predict a patient's risk of SSC and guide strategic utilization of sNPWT. This data-driven approach allows for optimization of clinical and financial outcomes by strategically allocating sNPWT based on personalized risk assessments.
C1 [Larson, Barrett J.; Roakes, Ashley; Yurick, Steve; Netravali, Nathan A.] Smith Nephew Inc, 2875 Railrd St, Pittsburgh, PA 15222 USA.
   [Larson, Barrett J.] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA USA.
C3 Stanford University
RP Larson, BJ (通讯作者)，Smith Nephew Inc, 2875 Railrd St, Pittsburgh, PA 15222 USA.
EM barrett.larson@stanford.edu
CR Badia JM, 2017, J HOSP INFECT, V96, P1, DOI 10.1016/j.jhin.2017.03.004
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
   Boland PA, 2021, IRISH J MED SCI, V190, P261, DOI 10.1007/s11845-020-02283-7
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
   Center for Disease Control National Healthcare Safety Network, 2023, SURG SITE INFECT EVE
   Centers for Medicare & Medicaid Services, MEDICARE PART B AVER
   Chalkidou A., 2018, EXTERNAL ASSESSMENT
   Chen KA, 2023, DIS COLON RECTUM, V66, P458, DOI 10.1097/DCR.0000000000002559
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   Fleming CA, 2018, J HOSP INFECT, V99, P75, DOI 10.1016/j.jhin.2017.10.022
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   Lawson EH, 2012, ANN SURG, V256, P973, DOI 10.1097/SLA.0b013e31826b4c4f
   Li YM, 2020, SURG INNOV, V27, P165, DOI 10.1177/1553350619893222
   Monahan M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232960
   Nherera LM, 2021, J WOUND CARE, V30, pS23, DOI 10.12968/jowc.2021.30.Sup5.S23
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Quality U.S.. Department of Health and Human Services Patient Safety Network, 2019, SURG SITE INFECT
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   Wang HS, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.771608
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   World Union of Wound Healing Societies, 2016, CLOS SURG INC MAN UN
   Wu GS, 2022, ANN MED SURG, V84, DOI 10.1016/j.amsu.2022.104956
   Zhu Y, 2021, J AM COLL SURGEONS, V232, P963, DOI 10.1016/j.jamcollsurg.2021.03.026
NR 31
TC 0
Z9 1
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAY 1
PY 2024
VL 25
IS 4
BP 315
EP 321
DI 10.1089/sur.2023.274
EA MAY 2024
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA QT2H4
UT WOS:001216723200001
PM 38696615
OA hybrid
DA 2026-07-24
ER

PT J
AU Manik, M
   Anandhi, A
   Sureshkumar, S
   Keerthi, AR
   Sudharshan, M
   Kate, V
AF Manik, Maharjan
   Anandhi, Amaranathan
   Sureshkumar, Sathasivam
   Keerthi, Andi Rajendharan
   Sudharshan, Mahalingam
   Kate, Vikram
TI Prophylactic Negative Pressure Wound Therapy in Reducing Surgical Site
   Infections in Closed Abdominal Incision: A Randomized Controlled Trial
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE surgical site infection; negative pressure wound therapy; clean
   contaminated wound; laparotomy
ID LAPAROTOMY INCISIONS; RISK; SURGERY
AB Objective: This study aimed to evaluate the efficacy of prophylactic negative pressure wound therapy (PNPWT) in reducing the incidence of surgical site infection (SSI) and other wound complications in closed abdominal incisions.
   Approach: This was a prospective, single-center, open-label parallel arm superiority randomized controlled trial conducted over 2 years. Participants were randomly assigned to PNPWT and standard surgical dressing (SSD) group. The occurrence of postoperative SSI within 30 days, other wound-related complications, length of hospital (LOH) stay, and readmission within 1 month among both the study group were studied.
   Results: A total of 140 participants were included, with 70 each randomized to the PNPWT and SSD groups. In this study, 28.5% and 5.8% developed SSI in the SSD and PNPWT groups, respectively (relative risk = 0.26; 95% confidence interval = 0.08-0.80; p = 0.001). Similarly, the incidence of seroma (7.2% vs. 18.5%, p = 0.016), wound dehiscence (0% vs. 4.2%, p = 0.244), superficial and deep SSI (5.7% vs. 24.3%, p = 0.001) and (0% vs. 4.2%, p = 0.244), and LOH stay (days) (9 vs. 10.5, p = 0.07) were less in PNPWT compared to SSD group. Innovation: Despite the advances in surgical care, SSI rates continue to be high. The present findings might facilitate the use of PNPWT as a novel preventive strategy to reduce SSI in closed abdominal incision.
   Conclusion: The PNPWT in closed incisions following elective laparotomy can reduce the incidence of SSI when compared to SSD. The use of PNPWT was associated with a lower incidence of superficial SSI and seroma but without significant reduction in hospital stay.
C1 [Manik, Maharjan; Anandhi, Amaranathan; Sureshkumar, Sathasivam; Keerthi, Andi Rajendharan; Sudharshan, Mahalingam; Kate, Vikram] Jawaharlal Inst Postgrad Med Educ & Res, Dept Surg, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Anandhi, A (通讯作者)，Jawaharlal Inst Postgrad Med Educ & Res, Dept Surg, Pondicherry 605006, India.
RI Amaranathan, Anandhi/K-1169-2019; Kate, Vikram/AAI-1547-2019
CR Aga E., 2015, Infectious Diseases, V47, P765
   Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Boland PA, 2021, IRISH J MED SCI, V190, P261, DOI 10.1007/s11845-020-02283-7
   Frazee R, 2018, J AM COLL SURGEONS, V226, P507, DOI 10.1016/j.jamcollsurg.2017.12.008
   Horan TC, 2008, AM J INFECT CONTROL, V36, P309, DOI 10.1016/j.ajic.2008.03.002
   James Sangma M D, 2019, Niger J Surg, V25, P14, DOI [10.4103/njs.njs_14_18, 10.4103/njs.NJS_14_18]
   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   Kuper TM, 2020, ANN SURG, V271, P67, DOI 10.1097/SLA.0000000000003435
   Lozano-Balderas G, 2017, AM SURGEON, V83, P512
   Malmsjo Malin, 2014, Eplasty, V14, pe15
   Mekhla, 2019, J FAM MED PRIM CARE, V8, P2258, DOI 10.4103/jfmpc.jfmpc_419_19
   Murphy PB, 2019, ANN SURG, V270, P38, DOI 10.1097/SLA.0000000000003111
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Sahebally SM, 2018, JAMA SURG, V153, DOI 10.1001/jamasurg.2018.3467
   Schurtz E, 2018, AM J SURG, V215, P113, DOI 10.1016/j.amjsurg.2017.08.009
   Tanner J, 2015, SURGERY, V158, P66, DOI 10.1016/j.surg.2015.03.009
   Tuuli MG, 2020, JAMA-J AM MED ASSOC, V324, P1180, DOI 10.1001/jama.2020.13361
   Wells CI, 2019, WORLD J SURG, V43, P2779, DOI 10.1007/s00268-019-05116-6
   Witt-Majchrzak Anna, 2015, Pol Przegl Chir, V86, P456, DOI [10.2478/pjs-2014-0082, 10.2478/pjs-2014-0082]
   Zaidi A, 2017, COLORECTAL DIS, V19, P283, DOI 10.1111/codi.13458
NR 21
TC 3
Z9 5
U1 1
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2024
VL 13
IS 3
BP 123
EP 130
DI 10.1089/wound.2023.0052
EA SEP 2023
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A3Y5D
UT WOS:001182617600001
PM 37646410
DA 2026-07-24
ER

PT J
AU Kaçmaz, HY
   Baser, M
   Sozuer, EM
AF Kacmaz, Hatice Yuceler
   Baser, Muruvvet
   Sozuer, Erdogan Mutevelli
TI Effect of Prophylactic Negative-Pressure Wound Therapy for High-Risk
   Wounds in Colorectal Cancer Surgery: A Randomized Controlled Trial
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE colorectal surgery; negative-pressure wound therapy; NPWT; surgical site
   infection; surgical wound complications; wound care
ID SURGICAL SITE INFECTION; POSTOPERATIVE COMPLICATIONS; GENERAL-SURGERY;
   LAPAROTOMY; MORTALITY; PREVENTION; MORBIDITY; COLECTOMY; INCISIONS;
   ASEPSIS
AB OBJECTIVE: To determine the effect of prophylactic negative-pressure wound therapy (pNPWT) in patients at high risk of surgical wound complications (SWCs) who underwent colorectal cancer (CRC) surgery.
   METHODS: In an open-label randomized controlled trial, 50 patients who underwent open CRC surgery between November 2018 and February 2020 were included. Participants were randomly assigned to the pNPWT group (n = 24) or control group (n = 26). For patients in the pNPWT group, the pNPWT device was placed on the wound for 7 days, whereas for patients in the control group, the wound was covered with a sterile gauze dressing. The primary outcome measured was 30-day SWCs: surgical site infection, hematoma, seroma, and wound dehiscence/evisceration. Secondary outcomes included postoperative wound infection assessment score and length of postoperative hospital stay.
   RESULTS: The incidence of 30-day SWCs differed significantly between the pNPWT and control groups (16.7% vs 53.8% respectively, P = .006). Patients in the pNPWT group had a significantly lower incidence of seroma than did those in the control group (8.3% vs 34.6%, P = .025). Surgical site infection occurred in 10 of 50 patients (20%) in the study: two (8.3%) in the pNPWT group and eight (30.8%) in the control group (P = .048). No hematomas or wound dehiscence/evisceration were noted in the study. There was no difference in median length of stay between groups (P = .153).
   CONCLUSIONS: This study confirmed that pNPWT effectively helps prevent SWCs in high-risk wounds after open CRC surgery.
C1 [Kacmaz, Hatice Yuceler] Erciyes Univ Kayseri, Dept Surg Dis Nursing, Kayseri, Turkey.
   [Baser, Muruvvet; Sozuer, Erdogan Mutevelli] Erciyes Univ Kayseri, Dept Gen Surg, Kayseri, Turkey.
C3 Erciyes University; Erciyes University
RP Kaçmaz, HY (通讯作者)，Erciyes Univ Kayseri, Dept Surg Dis Nursing, Kayseri, Turkey.
RI BASER, MURUVVET/AAL-7603-2021; Yüceler Kaçmaz, Hatice/AAL-6992-2021
OI Yüceler Kaçmaz, Hatice/0000-0003-4529-1991
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   [Anonymous], 2017, COLORECTAL CANC FACT
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NR 39
TC 6
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2022
VL 35
IS 11
BP 597
EP 603
DI 10.1097/01.ASW.0000874168.60793.10
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 5L5BA
UT WOS:000870427600008
PM 36264751
DA 2026-07-24
ER

PT J
AU Meshkin, DH
   Fan, KL
   Charipova, K
   Hill, C
   Evans, KK
   Steinberg, JS
   Kim, PJ
   Attinger, CE
AF Meshkin, Dean H. Y.
   Fan, Kenneth L.
   Charipova, Karina
   Hill, Christine
   Evans, Karen K.
   Steinberg, John S.
   Kim, Paul J.
   Attinger, Christopher E.
TI Long-Term Outcome Assessment Between Antiseptic and Normal Saline for
   Negative Pressure Wound Therapy with Instillation
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE wound healing; negative pressure wound therapy; normal saline; complex
   wounds
ID DIABETIC FOOT; INTERNATIONAL CONSENSUS; TOBACCO
AB Objective: To analyze long-term outcomes following inpatient treatment of infected wounds with antimicrobial or normal saline instillation during negative pressure wound therapy (NPWT).
   Approach: This was a single-center retrospective study analyzing the course of patients receiving 0.9% normal saline or 0.1% polyhexanide plus 0.1% betaine as instillation for wounds requiring surgery. Measured outcomes included rates of dehiscence, new wounds, re-operations, amputations, and mortality over 5 years. The article adheres to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.
   Results: Forty-two patients received normal saline instillation and 41 the antiseptic solution. Rates of dehiscence, wound recurrence, and re-operations in the saline and antiseptic cohorts were 6.3% and 5.6%, 9.4% and 5.6%, and 14.3% and 9.8%, respectively (p > 0.05). In patients requiring further surgery, time to wound closure averaged 104 and 130 days in the saline and antiseptic cohorts, respectively (p = 0.81). Five-year amputation and mortality rates were 14.3% and 22% (p = 0.36) and 24% and 17% (p = 0.45) in the saline and antiseptic cohorts, respectively.
   Innovation: To compare clinical outcomes associated with two fundamentally different instillation solutions over the full wound care episode and elucidate the potential impact of these results for future applications.
   Conclusion: This is the first evaluation of nonsurrogate outcomes of different instillations for NPWT in infected wounds. The results indicate that normal saline instillation outcomes are comparable to those of 0.1% polyhexanide plus 0.1% betaine. The clinical success, cost benefit, and accessibility of normal saline can expand the utilization of this therapeutic approach for larger patient populations.
C1 [Meshkin, Dean H. Y.; Charipova, Karina; Hill, Christine] Georgetown Univ, Sch Med, Dept Plast & Reconstruct Surg, Washington, DC 20007 USA.
   [Fan, Kenneth L.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Evans, Karen K.; Steinberg, John S.; Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW,First Floor PHC, Washington, DE 20007 USA.
   [Kim, Paul J.] William P Clements Jr Univ Hosp, Wound Care Ctr, Dept Plast Surg, Dallas, TX USA.
C3 Georgetown University; Georgetown University
RP Meshkin, DH (通讯作者)，Georgetown Univ, Sch Med, Dept Plast & Reconstruct Surg, Washington, DC 20007 USA.; Attinger, CE (通讯作者)，MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd NW,First Floor PHC, Washington, DE 20007 USA.
EM hr292@georgetown.edu; cattinger@aol.com
OI , Paul/0000-0002-6186-6890; Meshkin, Dean/0000-0002-8706-3690
CR Andriessen AE, 2008, WOUNDS, V20, P171
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NR 40
TC 3
Z9 4
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT 1
PY 2021
VL 10
IS 10
BP 535
EP 543
DI 10.1089/wound.2021.0023
EA JUN 2021
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA TN1PX
UT WOS:000661609200001
PM 33860686
DA 2026-07-24
ER

PT J
AU Kim, JH
   Lee, DH
AF Kim, Jun-Ho
   Lee, Dae-Hee
TI Are high-risk patient and revision arthroplasty effective indications
   for closed-incisional negative-pressure wound therapy after total hip or
   knee arthroplasty? A systematic review and meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE closed-incisional negative-pressure wound therapy; surgical site
   infection; total hip arthroplasty; total knee arthroplasty; wound
   complication
ID PERIPROSTHETIC JOINT INFECTION; SURGICAL-SITE INFECTIONS; POSTOPERATIVE
   MORTALITY; MEDICARE PATIENTS; MANAGEMENT; DRESSINGS; CALCULATOR; RATES;
   COMPLICATIONS; READMISSION
AB To determine the effective indications of closed-incisional negative-pressure wound therapy (ciNPWT) following total hip or knee arthroplasty, this systematic review and meta-analysis was conducted. The systematic search was performed on MEDLINE, Embase, and Cochrane Library, and 11 studies were included. The studies comparing between ciNPWT and conventional dressings were categorised into following subgroups based on patient risk and revision procedures: routine vs high-risk patient; primary vs revision arthroplasty. Pooled estimates were calculated for wound complication and surgical site infection (SSI) rates in the subgroup analyses using Review Manager. In high-risk patients, the overall rates of wound complication (odds ratio [OR] = 0.38; 95% confidence interval [CI] 0.15-0.93; P = .030) and SSI (OR = 0.24; 95% CI = 0.09-0.64; P = .005) were significantly lower in the ciNPWT; however, there were no differences in routine patients. In cases involving revision arthroplasties, the overall rates of wound complication (OR = 0.33; 95% CI = 0.18-0.62; P < .001) and SSI (OR = 0.26; 95% CI = 0.11-0.66; P = .004) were significantly lower in the ciNPWT; however, there were no differences in cases involving primary arthroplasties. In summary, ciNPWT showed a positive effect in decreasing the rates of wound complication and SSI in high-risk patients and in revision arthroplasties.
C1 [Kim, Jun-Ho] Seoul Med Ctr, Dept Orthoped Surg, Seoul, South Korea.
   [Lee, Dae-Hee] Sungkyunkwan Univ, Sch Med, Dept Orthopaed Surg, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Seoul Medical Center; Sungkyunkwan University (SKKU); Samsung Medical
   Center
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Sch Med, Dept Orthopaed Surg, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea.
EM eoak22@empal.com
RI lee, dae/I-9390-2017
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NR 50
TC 23
Z9 23
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1310
EP 1322
DI 10.1111/iwj.13393
EA MAY 2020
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000532562400001
PM 32406175
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Huang, Y
   Hu, JL
   Mao, BQ
   Ni, PW
   Shou, YY
   Hou, LL
   Xie, T
AF Huang, Yao
   Hu, Jiale
   Mao, Beiqian
   Ni, Pengwen
   Shou, Yuyan
   Hou, Lili
   Xie, Ting
TI Perspectives on the Process of Negative Pressure Wound Therapy at Home
   in Patients With Chronic Wound: A Qualitative Descriptive Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE wound healing; qualitative research; negative pressure wound therapy;
   home care services
ID PATIENTS EXPERIENCES; CARE; NPWT
AB The purpose of this study was to explore the experience of negative pressure wound therapy (NPWT) at home among Chinese chronic wound patients. Qualitative descriptive study design was adopted, and qualitative data were collected through semistructured in-depth interviews. A purposive, sampling method was used. Informants were recruited from one single wound healing center of a teaching hospital and were interviewed following one course of NPWT at home. A thematic content analysis was undertaken in the framework of input-process-output theory to guide analysis. Of the 13 participants interviewed, 9 were female and 4 were male with an age ranging from 20 to 69 years. Two major categories with their corresponding codes were identified. The first, positive experience, had 6 codes: high-degree identity and feeling hope (input); easy operation and convenience (process); improvement of symptoms and effective treatment (output). The second category, negative experience, had 11 codes: high expenditure, defects of the NPWT device, health education deficiency, and lack of independence and rationales in making decision of NPWT (input); poor communication with wound professionals, unexpected circumstances, therapeutic side effects, and a change of self-image (process); impact on physical symptoms and daily life, impact on social activities, and impact on psychological well-being (output). Patients considered the NPWT at home as a promising regimen, but they also had a feeling of not being prepared and lack of health education to make medical decision independently. The participants' perceptions and experiences would provide valuable information to promote the intervention program of health education and advance service process optimization.
C1 [Huang, Yao; Mao, Beiqian; Ni, Pengwen; Shou, Yuyan; Xie, Ting] Shanghai Jiao Tong Univ, Emergency Dept, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.
   [Huang, Yao] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai, Peoples R China.
   [Hu, Jiale] Virginia Commonwealth Univ, Dept Nurse Anesthesia, Richmond, VA 23284 USA.
   [Hou, Lili] Shanghai Jiao Tong Univ, Dept Nursing, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Virginia
   Commonwealth University; Shanghai Jiao Tong University
RP Hou, LL (通讯作者)，Shanghai Jiao Tong Univ, Dept Nursing, Ninth Peoples Hosp, Sch Med, Shanghai, Peoples R China.; Xie, T (通讯作者)，Shanghai Jiao Tong Univ, Wound Healing Ctr, Emergency Dept, Ninth Peoples Hosp,Sch Med, 166 Yan Zhen Rd, Shanghai 200125, Peoples R China.
EM houlili1977@hotmail.com; doctortingxie@139.com
RI Hu, Jiale/I-3949-2019
FU Gaoyuan Nursing Grant Support of Shanghai Municipal Education Commission
   [hlgy1904dxk]; Shanghai Jiao Tong University School of MedicineNursing
   Research Project [Jyh1905]; National Natural Science Foundation of China
   [81671917]; Nursing Research Project of Ninth People's Hospital
   Affiliated to Shanghai Jiao Tong University School of Medicine
   [JYHL20193D06]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   program was supported by grants from Gaoyuan Nursing Grant Support of
   Shanghai Municipal Education Commission (hlgy1904dxk), Shanghai Jiao
   Tong University School of MedicineNursing Research Project (Jyh1905),
   Nursing Research Project of Ninth People's Hospital Affiliated to
   Shanghai Jiao Tong University School of Medicine (JYHL20193D06), and the
   National Natural Science Foundation of China (81671917).
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NR 32
TC 6
Z9 8
U1 0
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 384
EP 396
AR 1534734620946577
DI 10.1177/1534734620946577
EA AUG 2020
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000558322100001
PM 32772902
DA 2026-07-24
ER

PT J
AU Heard, C
   Chaboyer, W
   Anderson, V
   Gillespie, BM
   Whitty, JA
AF Heard, Christopher
   Chaboyer, Wendy
   Anderson, Vinah
   Gillespie, Brigid M.
   Whitty, Jennifer A.
TI Cost-effectiveness analysis alongside a pilot study of prophylactic
   negative pressure wound therapy
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Wounds; Surgical site infection; Negative pressure wound therapy;
   Caesarean section; Cost-effectiveness analysis
ID SURGICAL SITE INFECTION; HEALTH
AB Background: Negative pressure wound therapy (NPWT) is increasingly used prophylactically following surgery despite limited evidence of clinical or cost-effectiveness.
   Objective: To evaluate whether NPWT is cost-effective compared to standard care, for the prevention of surgical site infection (SSI) in obese women undergoing elective caesarean section, and inform development of a larger trial.
   Methods: An economic evaluation was conducted alongside a pilot randomised controlled trial at one Australian hospital, in which women were randomised to NPWT (n = 44) or standard care (n = 43). A public health care provider perspective and time horizon to four weeks post-discharge was adopted. Cost-effectiveness assessment was based on incremental cost per SSI prevented and per quality-adjusted life year (QALY) gained.
   Results: Patients receiving NPWT each received health care costing AU$5887 (+/- 1038) and reported 0.069 (+/- 0.010) QALYs compared to AU$5754 (+/- 1484) and 0.066 (+/- 0.010) QALYs for patients receiving standard care. NPWT may be slightly more costly and more effective than standard care, with estimated incremental cost-effectiveness ratios (ICERs) of AU$1347 (95%CI dominant-$41,873) per SSI prevented and AU$42,340 (95%Cl dominant-$884,019) per QALY gained. However, there was considerable uncertainty around these estimates.
   Conclusions: NPWT may be cost-effective in the prophylactic treatment of surgical wounds following elective caesarean section in obese women. Larger trials could clarify the cost-effectiveness of NPWT as a prophylactic treatment for SSI. Sensitive capture of QALYs and cost offsets will be important given the high level of uncertainty around the point estimate cost-effectiveness ratio which was close to conventional thresholds. (C) 2016 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Heard, Christopher; Whitty, Jennifer A.] Univ Queensland, Fac Hlth & Behav Sci, Sch Pharm, St Lucia, Qld, Australia.
   [Chaboyer, Wendy; Anderson, Vinah; Gillespie, Brigid M.; Whitty, Jennifer A.] Griffith Univ, Ctr Res Excellence Nursing, NHMRC, Gold Coast, Qld, Australia.
   [Chaboyer, Wendy; Anderson, Vinah; Gillespie, Brigid M.; Whitty, Jennifer A.] Menzies Hlth Inst Queensland, Gold Coast, Qld, Australia.
   [Whitty, Jennifer A.] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
C3 University of Queensland; Griffith University; Menzies Health Institute
   Queensland; University of East Anglia
RP Whitty, JA (通讯作者)，Univ East Anglia, Fac Med & Hlth Sci, Norwich Med Sch, Hlth Econ Grp, Norwich Res Pk, Norwich NR4 7JT, Norfolk, England.
EM Jennifer.Whitty@uea.ac.uk
RI ; Chaboyer, Wendy/F-9588-2018; Gillespie, Brigid/E-7799-2012; Whitty,
   Jennifer/N-6434-2013
OI Anderson, Vinah/0000-0001-9924-0159; Chaboyer,
   Wendy/0000-0001-9528-7814; Gillespie, Brigid/0000-0003-3186-5691; 
FU Office of Health and Medical Research; Queensland Health; National
   Health and Medical Research Council Centre of Research Excellence in
   Nursing; Gold Coast University Hospital Private Practice grant;
   University of Queensland under the UQ Summer Research Scholarship
   program
FX The pilot study was funded by the Office of Health and Medical Research,
   Queensland Health, the National Health and Medical Research Council
   Centre of Research Excellence in Nursing and a Gold Coast University
   Hospital Private Practice grant. Christopher Heard received funding from
   The University of Queensland under the UQ Summer Research Scholarship
   program.
CR Andersson AE, 2010, AM J INFECT CONTROL, V38, P711, DOI 10.1016/j.ajic.2010.03.017
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NR 32
TC 42
Z9 43
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2017
VL 26
IS 1
SI SI
BP 79
EP 84
DI 10.1016/j.jtv.2016.06.001
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA EP0JO
UT WOS:000397073800011
PM 27320010
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Molasy, B
   Frydrych, M
   Kuchcinski, R
   Gluszek, S
AF Molasy, Bartosz
   Frydrych, Mateusz
   Kuchcinski, Rafal
   Gluszek, Stanislaw
TI Combining Topical Oxygen and Negative-Pressure Wound Therapy: New
   Insights from a Pilot Study on Chronic Wound Treatment
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE chronic wounds; wound healing; combined therapy; topical oxygen therapy;
   negative-pressure wound therapy; biomarkers; thermography
ID TO-HEAL WOUNDS
AB Background: Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed to assess the clinical effectiveness of combined TOT and NPWT in chronic wound treatment and to explore the prognostic value of selected laboratory and thermographic markers. Methods: Eighteen patients with chronic wounds due to type 2 diabetes mellitus or chronic venous insufficiency were treated with either TOT alone (control group) or TOT combined with NPWT (intervention group). Wound characteristics, thermographic data, and laboratory parameters (NLR, MLR, PLR, CRP, and total protein) were collected at baseline and during therapy. The primary endpoints were the total treatment duration and complete wound closure. Statistical analyses were exploratory and used non-parametric tests, correlation analyses, and simple linear regression. Results: Ulcer duration was significantly associated with the wound surface area. Lower serum total protein levels correlated negatively with ulcer duration, wound size, and granulation tissue area. A significant reduction in treatment duration was observed in the intervention group compared to the controls. One strong correlation was found between MLR and peripheral wound temperature on day 7 in the control group. No significant group differences were observed in wound size or thermographic measures after one week of treatment. Conclusions: Combining TOT and NPWT may reduce treatment duration in chronic wound management. Selected laboratory and thermographic markers show promise as prognostic tools. These exploratory findings require confirmation in larger, randomized trials.
C1 [Molasy, Bartosz] Jan Kochanowski Univ, Med Coll, PL-25317 Kielce, Poland.
   [Molasy, Bartosz; Frydrych, Mateusz; Kuchcinski, Rafal] St Alexander Hosp, Dept Gen Surg, PL-25316 Kielce, Poland.
   [Gluszek, Stanislaw] Holy Cross Canc Ctr, Dept Surg Oncol, PL-25734 Kielce, Poland.
   [Gluszek, Stanislaw] Polish Acad Sci, Inst Genet & Anim Biotechnol, PL-05552 Magdalenka, Poland.
C3 Jan Kochanowski University; Polish Academy of Sciences
RP Molasy, B (通讯作者)，Jan Kochanowski Univ, Med Coll, PL-25317 Kielce, Poland.; Molasy, B (通讯作者)，St Alexander Hosp, Dept Gen Surg, PL-25316 Kielce, Poland.
EM bartosz.molasy@onet.pl; frydrychmf@gmail.com; rafalk007@tlen.pl;
   sgluszek@wp.pl
RI Gluszek, Stanislaw/S-3303-2019; Molasy, Bartosz/JTV-0243-2023
OI Gluszek, Stanislaw/0000-0001-7752-0459; Molasy,
   Bartosz/0000-0003-3396-6242
CR Atasoy PY, 2026, INT J LOW EXTR WOUND, V25, P490, DOI 10.1177/15347346241235873
   Cates NK, 2022, SURG TECHNOL INT, V40
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NR 19
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG 7
PY 2025
VL 14
IS 15
AR 5564
DI 10.3390/jcm14155564
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6AQ2A
UT WOS:001548816900001
PM 40807185
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, QH
   Ren, XY
   Fang, XW
   Ding, JX
AF Yang, Qinghua
   Ren, Xiaoying
   Fang, Xiaowan
   Ding, Jiaxiang
TI The efficacy of cuff-shaving combined with negative pressure wound
   therapy in refractory exit-site and tunnel infections: a single center
   experience
SO BMC NEPHROLOGY
LA English
DT Article
DE Negative pressure wound therapy; Peritoneal dialysis catheter;
   Refractory exit-site infection; Superficial cuff-shaving; Tunnel
   infection
ID PREVENTION; REMOVAL
AB BackgroundRefractory exit-site infections (ESIs) and tunnel infections (TIs) are challenging complications for patients undergoing peritoneal dialysis (PD). This study compared the outcomes of surgical intervention, notably the cuff-shaving (CS) procedure coupled with negative-pressure wound therapy (NPWT), and conservative management strategies for patients with refractory ESI and TI.MethodsWe retrospectively reviewed patients who underwent PD at our center, focusing on the incidence and management of ESI and TI. We evaluated and compared treatment outcomes, including ESI scores, frequency of ESI and/or TI, identification of causative microorganisms, and duration of catheter survival or time until removal.ResultsWe identified 97 episodes of catheter-related ESI and/or TI across 71 patients with an incidence rate of 0.15 episodes per patient-year. Of the 23 patients with refractory ESI and/or TI, surgical intervention was performed in 8, while 15 chose conservative management. In the one-month follow-up, patients who underwent CS combined with NPWT showed no complications such as leakage, and their local symptoms resolved completely. The mean PD catheter survival time was significantly longer in the surgical group (29.38 +/- 7.25 months) than in the conservative group (7.86 +/- 2.13 months). Surgical intervention demonstrated a significantly higher therapeutic efficacy and extended catheter survival.ConclusionsThe combination of CS and NPWT as a surgical approach is crucial for eradicating infectious foci and significantly improving the longevity of PD catheter function. This integrated surgical strategy offers a promising solution for the management of refractory ESI and TI in patients undergoing PD.
C1 [Yang, Qinghua; Ren, Xiaoying; Fang, Xiaowan; Ding, Jiaxiang] Peking Univ Int Hosp, Nephrol Dept, 1 Life Pk Rd,Life Sci Pk Zhongguancun, Beijing 102206, Peoples R China.
C3 Peking University
RP Ding, JX (通讯作者)，Peking Univ Int Hosp, Nephrol Dept, 1 Life Pk Rd,Life Sci Pk Zhongguancun, Beijing 102206, Peoples R China.
EM Dingjiaxiang@pkuih.edu.cn
FU Peking University International Hospital Research Funds
FX No Statement Available
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NR 19
TC 0
Z9 0
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD AUG 26
PY 2024
VL 25
IS 1
AR 273
DI 10.1186/s12882-024-03714-8
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA D7G3O
UT WOS:001297825800001
PM 39187762
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lu, SW
   Yuan, Z
   He, XN
   Du, ZY
   Wang, Y
AF Lu, Shengwei
   Yuan, Zan
   He, Xinning
   Du, Zhiyong
   Wang, Ying
TI 被撤回的出版物: The impact of negative pressure wound therapy on surgical wound
   infection, hospital stay and postoperative complications after spinal
   surgery: A meta-analysis (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE complication; meta-analysis; negative pressure wound therapy; spine
   surgery; wound infection
ID SITE INFECTION; FUSION; DEHISCENCE
AB To systematically assess the effect of negative pressure wound therapy (NPWT) on postoperative surgical wound infection, length of hospital stay and postoperative complications after spinal surgery. Relevant studies on the application of NPWT in spinal surgery were conducted via a computerised database search, including PubMed, EMBASE, Web of Science, MEDLINE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang, from inception to June 2023. The identified literature was rigorously screened and data extraction was performed by two investigators independently. The quality of the relevant studies was evaluated using the Newcastle-Ottawa scale (NOS). The effect size for count data was determined by the odds ratio (OR), while the impact size for measurement data was expressed as the standardised mean difference (SMD). The 95% confidence interval (CI) was calculated for each effect magnitude. Stata 17.0 software was used for the meta-analysis. Ten papers, totalling 1448 patients, were finally included. This study demonstrated that NPWT led to a statistically significant reduction in the occurrence of postoperative surgical wound infections (OR: 0.377, 95% CI: 0.238-0.598, p < 0.001), fewer postoperative complications (OR: 0.526, 95% CI: 0.360-0.770, p = 0.001) and a shortened hospital stay (SMD: -0.678, 95%CI: -1.324 to -0.031, p = 0.040) after spinal surgery compared with the control group. When compared with other treatment approaches, NPWT also demonstrated a substantial reduction in surgical wound infections and postoperative complications, as well as a shorter duration of hospitalisation after spinal surgery.
C1 [Lu, Shengwei; Yuan, Zan; He, Xinning; Du, Zhiyong; Wang, Ying] Orthoped Hosp Tradit Chinese Med Zhuzhou City, Dept Spine, Zhuzhou 412007, Hunan, Peoples R China.
RP Wang, Y (通讯作者)，Orthoped Hosp Tradit Chinese Med Zhuzhou City, Dept Spine, Zhuzhou 412007, Hunan, Peoples R China.
EM wangying412007@163.com
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   Vidalis BM, 2022, WORLD NEUROSURG, V159, pE407, DOI 10.1016/j.wneu.2021.12.063
   Wang JM, 2022, INT ORTHOP, V46, P2629, DOI 10.1007/s00264-022-05531-w
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Xie WW, 2022, INT WOUND J, V19, P1319, DOI 10.1111/iwj.13726
   Yao R, 2018, GLOB SPINE J, V8, p5S, DOI 10.1177/2192568218799056
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NR 35
TC 4
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN
PY 2024
VL 21
IS 1
DI 10.1111/iwj.14378
EA SEP 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IT5Y8
UT WOS:001066293300001
PM 37697710
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, T
   Fan, LH
   Liu, JJ
   Tao, Y
   Li, X
   Wang, XJ
   Li, LM
AF Wang, Tao
   Fan, Longhua
   Liu, Jianjun
   Tao, Yue
   Li, Xu
   Wang, Xiaojun
   Li, Limeng
TI Negative Pressure Wound Therapy Promotes Wound Healing by Inhibiting
   Inflammation in Diabetic Foot Wounds: A Role for NOD1 Receptor
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE negative pressure wound therapy; NOD1 receptor; diabetic patients;
   inflammation
AB Aims: Diabetic foot results in frequent amputation and quality-of-life reduction in diabetes population. These lesions are featured by a prolonged and exaggerated inflammation with a significant impairment in local bacterial invasion. Negative pressure wound therapy (NPWT) attenuates hyperinflammation in the healing of diabetic foot wounds, but the potential mechanism of NPWT down-regulated inflammatory reaction still remains elusive. This study aims to explore the inflammatory signaling involved in the effect of NPWT on diabetic ulcer. Methods: Thirty patients with diabetic foot ulceration were divided into NPWT group (treated with NPWT, n = 10), NPWT + FK565 group (treated with NPWT combined with FK565 which is NOD1 receptor ligand, n = 10) and control group (n = 10). After two weeks treatment, samples were harvested and analyzed by histochemistry for infiltration of inflammatory cells, immunofluorescence stain for NOD1, western blotting for NOD1, RIP2 (Receptor interacting protein 2), IL-1 beta, TAK1 (Transforming growth factor-beta-activated kinase1), p65 and real time-PCR for expression of NOD1 and RIP2. Results: NPWT could notably accelerate the diabetic wound healing through alleviating inflammatory reaction. The immunofluorescence analysis results revealed that NOD1 was mainly expressed in the cytoplasm and noticeably decreased after the NPWT treatment. And NPWT obviously decreased both the mRNA and protein level of NOD1 and RIP2. Moreover, The protein expression of IL-1 beta, TAK1 and p65 in the NPWT-group were significant decreased. Conclusion: NPWT effectively promotes wound healing by suppressing the wound inflammation in diabetic foot, which is mediated at least in part by suppression of NOD1 receptor.
C1 [Wang, Tao; Fan, Longhua; Liu, Jianjun; Tao, Yue; Li, Xu; Wang, Xiaojun; Li, Limeng] Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Qingpu Branch, Shanghai, Peoples R China.
C3 Fudan University
RP Fan, LH (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Qingpu Branch, Shanghai, Peoples R China.
EM fanlonghua@163.com
RI Liu, Jianjun/AAK-4989-2020
OI , Wang/0000-0001-5462-2970
FU Hygiene and Health Commission of Qingpu District, Science and Technology
   Commission of Qingpu District, Shanghai Health Committee General
   Project, Shanghai Health Committee Youth Project [w2020-11, QKY201914,
   202040062, 202140227, 20194Y0286]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Hygiene and Health Commission of Qingpu District,
   Science and Technology Commission of Qingpu District, Shanghai Health
   Committee General Project, Shanghai Health Committee Youth Project,
   (grant number w2020-11, QKY201914, 202040062, 202140227, 20194Y0286).
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NR 31
TC 3
Z9 5
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2022 OCT 11
PY 2022
DI 10.1177/15347346221131844
EA OCT 2022
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 5F3HA
UT WOS:000866208300001
PM 36221954
DA 2026-07-24
ER

PT J
AU Davini, G
   Dini, V
   Janowska, A
   Macchia, M
   Gualtieri, B
   Granieri, G
   Romanelli, M
AF Davini, Giulia
   Dini, Valentina
   Janowska, Agata
   Macchia, Michela
   Gualtieri, Bruno
   Granieri, Giammarco
   Romanelli, Marco
TI Wound Dehiscence After Achilles Tendon Trauma and Repair: Treatment With
   Ultraportable Negative Pressure Wound Therapy and Compression Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE dehiscence; Achilles tendon; trauma; ultraportable; negative pressure
   wound therapy; wound healing
ID VENOUS LEG ULCERS; METAANALYSIS; INFECTIONS; MANAGEMENT
AB Introduction. Achilles tendon rupture is a common injury requiring surgical repair. Re-ruptures, infections, delayed wound healing, and hematomas have been reported postoperatively. Objective. This case series described the use of ultraportable negative pressure wound therapy (NPWT) and compression bandaging following postoperative dehiscence of Achilles tendon repair. Materials and Methods. Retrospective records were reviewed to identify patients who underwent wound management for Achilles tendon dehiscence between January 2014 and January 2018. Patient demographics, wound size at first and last visit, number of visits, and previous treatment data were extracted. Wound management included wound irrigation, surgical debridement, and application of silver dressings, as needed. Therapy was transitioned to ultraportable NPWT with twice-weekly dressing changes. When possible, patients with an ankle-brachial index greater than 0.8 received multilayer, multicomponent compression. Treatment response was evaluated using a wound imaging system at 2-week to 4-week intervals for a total of 24 weeks. Results. Nine male patients with a mean age of 69.7 years presented for care. One patient sustained injury during sports activities, and the other 8 patients sustained injuries resulting from household accidents. Six patients achieved complete wound closure. Three patients achieved a mean 90% wound closure. No adverse effects were observed during treatment with NPWT and compression therapy. Conclusions. In the current study, ultraportable NPWT and compression bandaging were found to be effective in the management of wounds with critical local vascularity. Larger, randomized controlled studies are necessary to fully assess the potential clinical benefit of NPWT and compression therapy in the management of postoperative wounds of the Achilles tendon.
C1 [Davini, Giulia; Dini, Valentina; Janowska, Agata; Macchia, Michela; Granieri, Giammarco; Romanelli, Marco] Univ Pisa, Sch Med & Surg, Dermatol Unit, Pisa, Italy.
   [Gualtieri, Bruno] Venezia Hosp, Dermatol Unit, Venice, Italy.
C3 University of Pisa
RP Romanelli, M (通讯作者)，Univ Pisa, Dept Dermatol, Via Roma 67, I-56126 Pisa, Italy.
EM romanellimarco6o@gmail.com
RI Janowska, Agata/HHS-7036-2022; romanelli, marco/ABI-1154-2020; Granieri,
   Giammarco/ACL-6360-2022; dini, valentina/F-7747-2017
OI Janowska, Agata/0000-0002-2271-3859; romanelli,
   marco/0000-0002-4127-0141; Granieri, Giammarco/0000-0002-6788-3253;
   dini, valentina/0000-0002-8537-1999
CR Arabyat RM, 2015, EXPERT OPIN DRUG SAF, V14, P1653, DOI 10.1517/14740338.2015.1085968
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NR 19
TC 5
Z9 5
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2021
VL 33
IS 12
BP E93
EP E98
DI 10.25270/wnds/2021.e93e98
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YU9EY
UT WOS:000752339500002
PM 35100134
DA 2026-07-24
ER

PT J
AU Gonzalez, MG
   Beloy, IC
   Dovigo, AG
   Fortes, LM
   Carbonell, TD
   Pita-Fernández, S
   Bouzán, JC
AF Garcia Gonzalez, Miriam
   Casal Beloy, Isabel
   Gomez Dovigo, Alba
   Miguez Fortes, Lorena
   Dargallo Carbonell, Teresa
   Pita-Fernandez, Salvador
   Carames Bouzan, Jesus
TI Negative Pressure Wound Therapy for a Complicated Abdominal Laparotomy
   in Neonatal Necrotizing Enterocolitis: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; neonate; necrotizing enterocolitis; surgical wound
   dehiscence; negative pressure wound therapy
ID BIRTH-WEIGHT INFANTS; PROSPECTIVE COHORT; PRETERM INFANTS; OPEN ABDOMEN;
   MANAGEMENT; CHILDREN; TRIALS; CARE
AB Necrotizing enterocolitis (NEC) is the most common surgical emergency in neonatal intensive care units, and patients who require surgery have high mortality and morbidity rates. The utility of negative pressure in the management of adults with complicated abdominal wounds has been documented, but there are few reports describing the use of negative pressure wound therapy (NPWT) in children or following neonatal surgery. The case of a 6 day old, 5-weeks premature neonate with NEC is presented. An exploratory midline laparotomy was performed on day 3 of life owing to rectal bleeding and abdominal distension that did not respond to gastric decompression, bowel rest, and intravenous antibiotics. Ten (10) cm of necrosis in the distal ileum were noted and resected; in addition, an ileostomy was performed, and a Penrose drain was left in the surgical site. On postoperative day 5, the laparotomy dehisced. Continuous NPWT (50 mm Hg) was initiated and changed owing to patient tolerance to intermittent therapy (5 minutes on, 30 seconds off) at 80 mm Hg. By postoperative day 11, granulation tissue formation was complete. No surgical procedures were required for the complete closure of the abdominal wall, and no adverse reactions were noted. The baby was discharged from the hospital on postop day 15. In this patient, the use of negative pressure was found to be safe and facilitated management of a complicated abdominal wound in the presence of a stoma and the formation of healthy granulation tissue. Additional research is needed to help clinicians provide optimal, evidence-based care for dehisced wounds in this vulnerable population.
C1 [Garcia Gonzalez, Miriam; Casal Beloy, Isabel; Miguez Fortes, Lorena; Dargallo Carbonell, Teresa; Carames Bouzan, Jesus] Univ Hosp A Coruna, Dept Pediat Surg, La Coruna, Spain.
   [Gomez Dovigo, Alba] Quiron Hosp A Coruna, La Coruna, Spain.
   [Pita-Fernandez, Salvador] Univ Hosp A Coruna, Clin Epidemiol & Biostat Res Grp, La Coruna, Spain.
C3 Complejo Hospitalario Universitario A Coruna; Complejo Hospitalario
   Universitario A Coruna
RP Gonzalez, MG (通讯作者)，Univ Hosp A Coruna, Dept Pediat Surg, La Coruna, Spain.; Gonzalez, MG (通讯作者)，Complejo Hosp Univ A Coruna, Xubias Abajo S-N, La Coruna 15006, Spain.
EM Miriam.ciruped@gmail.com
RI Casal-Beloy, Isabel/ABF-7555-2021; pita-fernandez, salvador/K-2191-2014;
   /AAF-5983-2021
OI Casal-Beloy, Isabel/0000-0003-1762-8382; 
CR Aguayo P, 2009, J SURG RES, V157, P275, DOI 10.1016/j.jss.2009.06.005
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NR 18
TC 3
Z9 6
U1 1
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2017
VL 63
IS 6
BP 34
EP 38
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FW5UV
UT WOS:000425385500003
PM 28657898
DA 2026-07-24
ER

PT J
AU Thomas, JR
   Crystal, DT
   Patel, SD
   Kim, J
   Habarth-Morales, TE
   Broach, RB
   Kanchwala, SK
   Azoury, SC
AF Thomas, Jacob R.
   Crystal, Dustin T.
   Patel, Shiv D.
   Kim, Jusung
   Habarth-Morales, Theodore E.
   Broach, Robyn B.
   Kanchwala, Suhail K.
   Azoury, Said C.
TI Negative Pressure Wound Therapy and Donor Site Morbidity in DIEP and
   Tram Flap Reconstruction: A Single-Center Longitudinal Review
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Review; Early Access
DE negative pressure wound therapy; incisional wound vac; DIEP flap; TRAM
   flap; autologous breast reconstruction; abdominal morbidity
ID BREAST RECONSTRUCTION; COMPLICATIONS; SMOKING; IMPACT; MANAGEMENT
AB Background Abdominally based breast free flap reconstruction exposes patients to potential significant donor site morbidity. Utilization of postoperative Incisional Negative Pressure Wound Therapy (iNPWT) has been proposed to minimize incision site complications. This study aims to assess if iNPWT reduces rates of donor site complications after DIEP and TRAM flap harvest. Methods This single-center, retrospective study included patients who underwent Deep Inferior Epigastric Artery (DIEP) or Transverse Rectus Abdominis Muscle (TRAM) flap reconstruction from 2022 to 2024. Patients' abdominal donor sites received either standard wound care or iNPWT at the time of reconstruction. Results A total of 362 patients were identified with a median age of 51.3 (IQR: 43.3-59.6) years. Rates of delayed healing at the donor site were lower in the iNPWT cohort compared to standard of care (13.4% vs. 35.3%, p < 0.001). Controlling for tobacco exposure, diabetes, hypertension, and laterality, there was a lower likelihood of delayed healing in the iNPWT cohort (OR: 0.249 [0.14-0.43], p < 0.001). This finding persisted in current and former smokers (OR: 0.269 [0.16-0.46], p < 0.001) and patients with comorbid hypertension (OR: 0.257 [0.15-0.44], p < 0.001). Conclusion These results suggest iNPWT usage is associated with lower rates of donor site delayed healing after DIEP and TRAM procedures in the general patient population and should be considered in those with two or more vascular risk factors. Further investigation is required to stratify the risk of delayed healing for patients with concomitant hypertension, tobacco exposure, diabetes, and/or obesity.
C1 [Thomas, Jacob R.; Crystal, Dustin T.; Patel, Shiv D.; Kim, Jusung; Habarth-Morales, Theodore E.; Broach, Robyn B.; Kanchwala, Suhail K.; Azoury, Said C.] Univ Penn, Dept Surg, Div Plast Surg, Philadelphia, PA USA.
   [Thomas, Jacob R.; Patel, Shiv D.; Kim, Jusung] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Azoury, SC (通讯作者)，Univ Penn, Perelman Ctr Adv Med, 3400 Civ Ctr Blvd,14th Floor,South Bldg, Philadelphia, PA 19104 USA.
EM Said.azoury@pennmedicine.upenn.edu
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   Xu Y, 2023, BMC SURG, V23, DOI 10.1186/s12893-023-02280-4
   Zaver V., 2025, NEGATIVE PRESSURE WO
NR 31
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD 2026 MAR 13
PY 2026
DI 10.1055/a-2824-6484
EA MAR 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FB2JR
UT WOS:001714613000001
PM 41776943
DA 2026-07-24
ER

PT J
AU García, AF
   Sánchez, AI
   Gutiérrez, AJ
   Bayona, JG
   Naranjo, MP
   Lago, S
   Puyana, JC
AF Federico Garcia, Alberto
   Ignacio Sanchez, Alvaro
   Jose Gutierrez, Alvaro
   Gabriel Bayona, Juan
   Paula Naranjo, Maria
   Lago, Sebastian
   Carlos Puyana, Juan
TI Effect of abdominal negative-pressure wound therapy on the measurement
   of intra-abdominal pressure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 18th European Congress of Trauma and Emergency Surgery
CY MAY 07-09, 2017
CL Bucharest, ROMANIA
DE Negative-pressure wound therapy; Intra-abdominal hypertension; Abdominal
   compartment syndrome; Critical care; Surgical decompression; Laparotomy
ID COMPARTMENT SYNDROME; CLOSURE TECHNIQUES; HYPERTENSION
AB Background: In critically ill surgical patients undergoing abdominal negative-pressure wound therapy (NPWT), it remains uncertain whether or not intra-abdominal pressure (IAP) measurements should be obtained when NPWT is activated. We aimed to determine agreement between IAP measured with and without NPWT.
   Methods: In this analytic cross-sectional study, critically ill surgical adults (>= 18 y) requiring abdominal NPWT for temporary abdominal closure after a damage control laparotomy were selected. Patients with urinary tract injuries or with pelvic packing were excluded. Paired IAP measures were performed in the same patient, with and without NPWT; two different operators performed the measures unaware of the other's result. Bland-Altman methods assessed the agreement between the two measures. Subgroup analyses (trauma and nontrauma) were performed.
   Results: There were 198 IAP measures (99 pairs) in 38 patients. Mean IAP with and without NPWT were 8.33 (standard deviation 4.01) and 8.65 (standard deviation 4.04), respectively. Mean IAP difference was -0.323 (95% confidence interval -0.748 to 0.101), and reference range for difference was -4.579 to 3.932 (P = 0.864). From 112 IAP measures (56 pairs) in 21 trauma patients, mean IAP difference was -0.268 (95% confidence interval -0.867 to 0.331), and reference range for the difference was -4.740 to 4.204 (P = 0.427).
   Conclusions: There was no statistically significant disagreement in IAP measures. IAP could be measured with or without NPWT. In critically ill surgical patients with abdominal NPWT for temporary abdominal closure, monitoring and management of IAP either with or without NPWT is recommended. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Federico Garcia, Alberto; Ignacio Sanchez, Alvaro] Fdn Valle Lili, Dept Surg, Cali, Colombia.
   [Ignacio Sanchez, Alvaro; Gabriel Bayona, Juan; Paula Naranjo, Maria] Fdn Valle Lili, Ctr Clin Res CIC, Cali, Colombia.
   [Jose Gutierrez, Alvaro; Lago, Sebastian] Univ ICESI, Sch Med, Cali, Colombia.
   [Carlos Puyana, Juan] Univ Pittsburgh, UPMC Presbyterian Hosp, Dept Surg, Pittsburgh, PA USA.
C3 Fundacion Valle del Lili; Fundacion Valle del Lili; Universidad ICESI;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; UPMC Presbyterian
RP Sánchez, AI (通讯作者)，Fdn Valle Lili, Carrera 98 18-49,Torre 7,Piso 3 CIC, Cali, Colombia.
EM alvaroisanchezortiz@gmail.com
RI ; Rueda Bayona, Juan Gabriel/AAQ-7604-2020; SANCHEZ ORTIZ,
   ALVARO/AFV-6810-2022
OI Naranjo Nates, María Paula/0009-0006-6735-9933; Puyana, Juan
   Carlos/0000-0003-4284-4693; Rueda Bayona, Juan
   Gabriel/0000-0003-3806-2058; SANCHEZ ORTIZ, ALVARO/0000-0001-6199-3358;
   García, Alberto Federico/0000-0002-4096-1434
FU Center of Clinical Research (CIC) at the Fundacion Valle del Lili
FX This work was supported by the Center of Clinical Research (CIC) at the
   Fundacion Valle del Lili.
CR Benninger E, 2008, J SURG RES, V144, P102, DOI 10.1016/j.jss.2007.02.021
   Benninger E, 2009, J TRAUMA, V66, P1118, DOI 10.1097/TA.0b013e3181820d94
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NR 14
TC 4
Z9 6
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUL
PY 2018
VL 227
BP 112
EP 118
DI 10.1016/j.jss.2018.02.030
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GG9ZD
UT WOS:000433059300015
PM 29804842
DA 2026-07-24
ER

PT J
AU Shang, YR
   Guo, SY
   Song, SK
   Tong, MY
   Gong, Y
   Liu, X
   Li, Z
   Song, MZ
AF Shang, Yuru
   Guo, Shiyi
   Song, Shukun
   Tong, Mengying
   Gong, Ying
   Liu, Xin
   Li, Zhen
   Song, Mingzhi
TI Negative Pressure Wound Therapy and Ultrasound Monitoring for
   Fracture-Related Infection of the Proximal Femur: A Case Report
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE fracture-related infection; hip fracture; negative pressure wound
   therapy; surgical wound infection; ultrasonography; wound healing
ID COMPLICATIONS
AB Background: Fracture-related infection (FRI) is one of the main complications of hip fracture. Negative pressure wound therapy (NPWT) seems to be a potential solution for FRI, because of offering exudate management, drainage enhancement, and tissue repair. Additionally, ultrasound cannot be ignored because of its role in evaluating musculoskeletal tissue infections. Case Presentation: A 55-year-old man mainly suffered from a fracture of the right proximal femur. The fracture was classified as AO/OTA 31-A3. The patient had a history of smoking. After internal fixation of the fracture and other symptomatic treatment, the patient was discharged. However, the surgical incision dehisced one month later. After examination, the patient was diagnosed with FRI with wound disruption and sinus tract formation. The blurred parafemoral shadow in X-ray, positive bacterial culture result, abnormal secretions, and elevated C-reactive protein and erythrocyte sedimentation rate were the bases for diagnosing FRI. In the course of treatment, we made full use of NPWT following limited debridement surgery to effectively treat FRI, and then continuously monitored the changes of lesions in deep infected areas through ultrasound detection. Intravenous infusion of ceftazidime and local rinsing with vancomycin solution were applied during the treatment process. Follow-up results showed that the patient had no recurrence of infection or other adverse events three months after treatment. Conclusion: This case shows that NPWT combined with ultrasound monitoring can control early fracture-related infection and allow implant retention. This treatment method may be applicable to areas with scarce medical resources. But larger-scale validation is still needed before clinical adoption.
C1 [Shang, Yuru] Shenzhen Univ, South China Hosp, Med Sch, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China.
   [Shang, Yuru] Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasound, Natl Reg Key Technol Engn Lab Med Ultrasound, Sch Biomed Engn,Med Sch, Shenzhen, Guangdong, Peoples R China.
   [Guo, Shiyi; Song, Mingzhi] Jining Med Univ, Inst Translat Med, Rizhao, Shandong, Peoples R China.
   [Guo, Shiyi] Jining Med Univ, Sch Pharm, Rizhao, Shandong, Peoples R China.
   [Song, Shukun] Chaoyang Cty Cent Hosp, Dept Orthopaed, Chaoyang, Liaoning, Peoples R China.
   [Tong, Mengying] Dalian Med Univ, Affiliated Hosp 1, Dept Ultrasound, Dalian, Liaoning, Peoples R China.
   [Gong, Ying] Dalian Med Univ, Affiliated Hosp 1, Dept Nursing, Dalian, Liaoning, Peoples R China.
   [Gong, Ying] Dalian Med Univ, Affiliated Hosp 1, Dept Orthopaed, Dalian, Liaoning, Peoples R China.
   [Liu, Xin; Li, Zhen] Shenzhen Pingshan Tradit Chinese Med Hosp, Shenzhen Pingle Orthoped Hosp, Printing Ctr 3D, Shenzhen, Guangdong, Peoples R China.
   [Li, Zhen] Shenzhen Pingshan Tradit Chinese Med Hosp, Shenzhen Pingle Orthoped Hosp, Dept Nursing, Shenzhen, Guangdong, Peoples R China.
   [Song, Mingzhi] Jining Med Univ, Affiliated Hosp, Dept Orthoped, Jining, Shandong, Peoples R China.
   [Song, Mingzhi] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai, Shanghai, Peoples R China.
C3 Shenzhen University; Shenzhen University; Jining Medical University;
   Jining Medical University; Dalian Medical University; Dalian Medical
   University; Dalian Medical University; Jining Medical University;
   Shanghai Jiao Tong University
RP Song, MZ (通讯作者)，Jining Med Univ, Inst Translat Med, Rizhao, Shandong, Peoples R China.; Song, MZ (通讯作者)，Jining Med Univ, Affiliated Hosp, Dept Orthoped, Jining, Shandong, Peoples R China.; Song, MZ (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai, Shanghai, Peoples R China.
EM songmingzhi@sjtu.edu.cn
FU Shandong Taishan Scholars Young Experts Program [tsqn202507263]
FX This work was supported by Shandong Taishan Scholars Young Experts
   Program (No.tsqn202507263).
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2026
VL 19
AR 575912
DI 10.2147/IDR.S575912
PG 7
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA EQ4UX
UT WOS:001707303600001
PM 41809938
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hu, CJ
   Lai, Y
   Jiang, YQ
   Wen, T
   Gao, GM
   Li, HB
   Long, H
AF Hu Chia-Jui
   Lai Yu
   Jiang, Yu-qing
   Wen Tan
   Gao, Gong-ming
   Li, Hai-bo
   Long Han
TI Negative pressure wound therapy, artificial skin and autogenous skin
   implantation in diabetic foot ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE artificial skin; autogenous skin implantation; diabetes; diabetic foot
   ulcer; Integra artificial skin; negative-pressure wound therapy; skin
   transplantation; wound; wound care; wound dressing; wound healing
ID ULCERATION; DERMIS; PREVENTION; AMPUTATION; EFFICACY; GRAFT
AB Objective: Diabetic foot ulcers (DFUs) are one of the most serious diabetic consequences, leading to amputations. Various therapies have been used to treat DFUs; however, a combination of negative pressure suction, artificial skin and autogenous skin implantation have never been investigated. This study aimed to evaluate the effectiveness of a novel three-step therapy protocol using negative pressure wound therapy (NPWT), artificial skin and autogenous skin implantation in patients with DFUs.
   Method: At a single tertiary university hospital between 2015 and 2018, the three-step therapy protocol was applied to patients with DFUs and its safety and efficacy was investigated.
   Results: A total of 21 patients took part in the study. The majority of the patients were female (62%), with a mean age of 65 years and a mean body mass index of 21kg/m(2). A third (n=7) of operative sites experienced minor complications, with two requiring re-operation. At a median follow up of 24 months, the average time of complete wound healing was 46 days, and the wound healing rate was 71%. The first-stage wound healing rate was 90%. All patients had achieved remission without any further recurrence of disease.
   Conclusion: This comprehensive surgical technique for managing DFUs achieved a high local cure rate, minimal functional morbidity, and acceptable wound complication rates. The three-step therapy protocol has the potential to promote the healing process of DFUs, which is expected to serve as a new method for the treatment and cure of DFUs.
C1 [Hu Chia-Jui; Lai Yu; Jiang, Yu-qing] Xiamen ChangGung Hosp, Dept Orthoped, Xiamen, Fujian, Peoples R China.
   [Wen Tan; Gao, Gong-ming; Li, Hai-bo; Long Han] Nanjing Med Univ, Dept Orthoped, Affiliated Changzhou 2 Peoples Hosp, Changzhou City, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Long, H (通讯作者)，Nanjing Med Univ, Dept Orthoped, Affiliated Changzhou 2 Peoples Hosp, Changzhou City, Jiangsu, Peoples R China.
EM darksonnight@163.com
RI HAN, LONG/JCO-8258-2023
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NR 43
TC 4
Z9 4
U1 0
U2 28
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2022
VL 31
IS 1
BP 40
EP 46
DI 10.12968/jowc.2022.31.1.40
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YU4EW
UT WOS:000751999300006
PM 35077212
DA 2026-07-24
ER

PT J
AU Aparicio-Sánchez, D
   Pintor-Tortolero, J
   Perea-Del Pozo, E
   Tallón-Aguilar, L
   Padillo-Ruiz, FJ
AF Aparicio-Sanchez, Daniel
   Pintor-Tortolero, Jose
   Perea-Del Pozo, Eduardo
   Tallon-Aguilar, Luis
   Javier Padillo-Ruiz, Francisco
TI Association of Negative Pressure Wound Therapy and Dermatotraction for
   Management of Necrotizing Soft Tissue Infections: A Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; dermatotraction; NPWT; wound closure
   techniques; wound infection; necrotizing fasciitis
ID FASCIITIS
AB Introduction. Soft tissue infections (STIs), which include infections of the skin, subcutaneous tissue, fascia, and muscle, encompass a wide variety of heterogeneous pathologies. Treatment of STIs is based on surgical debridement of the affected area. One such treatment, negative pressure wound therapy (NPWT), has improved the management of STIs. Objective. The purpose of this study is to assess the safety and utility of NPWT in conjunction with dermatotraction in the early stage management of necrotizing STIs. Materials and Methods. The authors report a retrospective series of 3 cases in which NPWT and dermatotraction (NPWT-D) were used in an attempt to manage necrotizing STI. The NPWT-D device combination was employed to approximate the edges of the wounds. The NPWT device was changed every 2 or 3 days, and dermatotraction tension was adjusted concurrently. Results. The NPWT-D device changes ranged from 3 to 4 times for 2 of the 3 patients, as 1 patient passed away secondary to STIs and therefore did not receive complete treatment. The total treatment ranged from 8 to 10 days in the remaining 2 patients. In both cases, complete wound closure was achieved while avoiding skin grafts. After 5 days of therapy in the incomplete treatment case, the wound area was reduced by about half. Conclusions. Based on the experiences herein, NPWT-D may be a safe and useful alternative surgical treatment for the management of necrotizing STIs. In the present cases, NPWT-D improved and shortened the wound healing process, and it achieved a tertiary wound closure, thereby avoiding the need for skin grafts.
C1 [Aparicio-Sanchez, Daniel; Pintor-Tortolero, Jose; Perea-Del Pozo, Eduardo; Tallon-Aguilar, Luis] Virgen del Rocio Univ Hosp, Emergency Surg Unit, Seville, Spain.
   [Javier Padillo-Ruiz, Francisco] Virgen del Rocio Univ Hosp, Gen Surg Unit, Seville, Spain.
C3 Virgen del Rocio University Hospital; Virgen del Rocio University
   Hospital
RP Aparicio-Sánchez, D (通讯作者)，Hosp Univ Virgen del Rocio, Serv Cirugia Gen & Aparato Digest, Avda Manuel Siurot S-N, Seville 41013, Spain.
EM daniel.apariciosanchez@gmail.com
RI Aparicio-Sánchez, Daniel/AAC-1266-2020; Tallon-Aguilar,
   Luis/JHV-1215-2023
OI Tallon-Aguilar, Luis/0000-0002-7549-619X; Pintor-Tortolero,
   José/0000-0003-1648-5156
CR Chen SJ, 2019, J ORAL MAXIL SURG, V77, P87, DOI 10.1016/j.joms.2018.08.016
   Gestring M., NEGATIVE PRESSURE WO
   Lee JY, 2014, WORLD J EMERG SURG, V9, DOI 10.1186/1749-7922-9-29
   Madsen MB, 2019, INTENS CARE MED, V45, P1241, DOI 10.1007/s00134-019-05730-x
   Maya SP, 2014, SKELETAL RADIOL, V43, P577, DOI 10.1007/s00256-013-1813-2
   Pintor-Tortolero J, 2019, ANZ J SURG, V89, pE49, DOI 10.1111/ans.14959
   Wong CH, 2003, J BONE JOINT SURG AM, V85A, P1454, DOI 10.2106/00004623-200308000-00005
NR 7
TC 0
Z9 0
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2020
VL 32
IS 8
BP 217
EP 220
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6LH
UT WOS:000613554600003
PM 33166261
DA 2026-07-24
ER

PT J
AU Soares, MO
   Dumville, JC
   Ashby, RL
   Iglesias, CP
   Bojke, L
   Adderley, U
   McGinnis, E
   Stubbs, N
   Torgerson, DJ
   Claxton, K
   Cullum, N
AF Soares, Marta O.
   Dumville, Jo C.
   Ashby, Rebecca L.
   Iglesias, Cynthia P.
   Bojke, Laura
   Adderley, Una
   McGinnis, Elizabeth
   Stubbs, Nikki
   Torgerson, David J.
   Claxton, Karl
   Cullum, Nicky
TI Methods to Assess Cost-Effectiveness and Value of Further Research When
   Data Are Sparse: Negative-Pressure Wound Therapy for Severe Pressure
   Ulcers
SO MEDICAL DECISION MAKING
LA English
DT Article
DE Markov model; elicited evidence; pilot trial; negative pressure wound
   therapy; sparse; evidence synthesis; expected value of information;
   research design; cost-effectiveness analysis
ID RANDOMIZED CONTROLLED-TRIAL; VENOUS LEG ULCERS; EXPECTED VALUE;
   PROBABILITY-DISTRIBUTIONS; INFORMATION ANALYSIS; DECISION-MAKING;
   MULTICENTER; EFFICACY; MODEL; CARE
AB Health care resources are scarce, and decisions have to be made about how to allocate funds. Often, these decisions are based on sparse or imperfect evidence. One such example is negative-pressure wound therapy (NPWT), which is a widely used treatment for severe pressure ulcers; however, there is currently no robust evidence that it is effective or cost-effective. This work considers the decision to adopt NPWT given a range of alternative treatments, using a decision analytic modeling approach. Literature searches were conducted to identify existing evidence on model parameters. Given the limited evidence base, a second source of evidence, beliefs elicited from experts, was used. Judgments from experts on relevant (uncertain) quantities were obtained through a formal elicitation exercise. Additionally, data derived from a pilot trial were also used to inform the model. The 3 sources of evidence were collated, and the impact of each on cost-effectiveness was evaluated. An analysis of the value of further information indicated that a randomized controlled trial may be worthwhile in reducing decision uncertainty, where from a set of alternative designs, a 3-arm trial with longer follow-up was estimated to be the most efficient. The analyses presented demonstrate how allocation decisions about medical technologies can be explicitly informed when data are sparse and how this kind of analyses can be used to guide future research prioritization, not only indicating whether further research is worthwhile but what type of research is needed and how it should be designed.
C1 [Soares, Marta O.; Bojke, Laura; Claxton, Karl] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [Dumville, Jo C.; Ashby, Rebecca L.; Iglesias, Cynthia P.; Torgerson, David J.] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [Adderley, Una] Univ Teesside, Sch Hlth & Social Care, Middlesbrough, Cleveland, England.
   [McGinnis, Elizabeth] Leeds Gen Infirm, Leeds Teaching Hosp Natl Hlth Serv NHS Trust, Leeds, W Yorkshire, England.
   [Stubbs, Nikki] St Marys Hosp, NHS Leeds Community Healthcare, Leeds, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of York - UK; University of York - UK; University of
   Teesside; Leeds General Infirmary; University of Leeds; University of
   Manchester
RP Soares, MO (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5DD, N Yorkshire, England.
EM marta.soares@york.ac.uk
RI Cullum, Nicky/F-2438-2011; McGinnis, Elizabeth/PNF-2864-2026; Torgerson,
   David/L-4566-2019; Soares, Marta Ferreira Oliveira/HJH-3434-2023;
   Dumville, Jo/O-7867-2014
OI Cullum, Nicky/0000-0003-2631-123X; Torgerson, David/0000-0002-1667-4275;
   Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Adderley,
   Una/0000-0003-1894-3755; Dumville, Jo/0000-0002-6546-3685; McGinnis,
   Elizabeth/0000-0002-2848-9149
FU Medical Research Council [G0501814]; MRC [G0501892, G0501814] Funding
   Source: UKRI; Medical Research Council [G0501814, G0501892] Funding
   Source: researchfish; National Institute for Health Research
   [NF-SI-0512-10028] Funding Source: researchfish
FX Received 10 February 2011 from the Centre for Health Economics, The
   University of York, York, UK (MOS, LB, KC); Department of Health
   Sciences, The University of York, York, UK (JCD, RLA, CI, DT); School of
   Health and Social Care, Teesside University, Middlesbrough, UK (UA);
   Leeds Teaching Hospitals National Health Service (NHS) Trust, Leeds
   General Infirmary, Leeds, UK (EM); NHS Leeds Community Healthcare, St
   Mary's Hospital, Leeds, UK (NS); and School of Nursing, Midwifery and
   Social Work, University of Manchester, Manchester, UK (NC). This work
   was supported by the Medical Research Council (grant number G0501814).
   Kinetic Concepts Inc. supplied the NPWT machines used in the pilot trial
   at no cost. The manufacturer had no role in the design of the pilot
   trial or in the collection, analysis, and interpretation of the data.
   Revision accepted for publication 24 March 2012.
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NR 52
TC 24
Z9 29
U1 1
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0272-989X
EI 1552-681X
J9 MED DECIS MAKING
JI Med. Decis. Mak.
PD APR
PY 2013
VL 33
IS 3
SI SI
BP 415
EP 436
DI 10.1177/0272989X12451058
PG 22
WC Health Care Sciences & Services; Health Policy & Services; Medical
   Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA 113RH
UT WOS:000316685000012
PM 22927694
DA 2026-07-24
ER

PT J
AU Kerivan, LT
   Vilain, KA
   Hill, TM
   Guidry, CA
AF Kerivan, Lauren T.
   Vilain, Katherine A.
   Hill, Terra M.
   Guidry, Christopher A.
TI Closed Incisional Negative Pressure Wound Therapy is Cost-Effective at
   Reducing Superficial Surgical Site Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE cost-effectiveness; decision analysis; negative-pressure wound therapy;
   prevention; surgical site infections
ID AMERICAN-COLLEGE; DRESSINGS; TRAUMA
AB Background: Surgical site infections (SSIs) have a significant health economic burden, accounting for more than US $3.3 billion in costs, and lead to increased microbial resistance, prolonged hospital stays, elevated 30-day mortality rates, greater incidences of reoperation, and decreased quality of life. Recently, evidence has emerged suggesting that prophylactic closed incision negative pressure wound therapy (ciNPWT) may substantially reduce the risk of post-operative wound complications, specifically SSIs. This study aimed to evaluate whether ciNPWT is cost-effective compared with routine incision care for the prevention of superficial SSIs.Hypothesis: We hypothesized that ciNPWT is cost-effective compared with routine incision care for the prevention of superficial SSIs.Methods: A cost-effectiveness decision analytic model was created comparing the use and non-use of ciNPWT. Superficial SSI probabilities, cost of care for patients with and without post-operative infection, and quality of life Short Form (SF)-36 survey data were obtained from a literature review. Cost of ciNPWT was obtained from health administrative data. A decision tree was constructed using TreeAge Software Pro Version 2020 (TreeAge Software, Inc., Williamstown, MA). Deterministic and probabilistic sensitivity analyses were performed to evaluate the robustness and reliability of the model.Results: One-way sensitivity analysis with a willingness-to-pay threshold of $5,000 demonstrated that above a baseline infection rate of approximately 6.4%, ciNPWT is cost-effective at reducing superficial SSI. Probabilistic sensitivity analysis indicated that even with uncertainty present in the parameters analyzed, the majority of simulations (95.4%) favored ciNPWT as the more effective tactic.Conclusions: Despite the added device cost, ciNPWT is cost-effective for superficial SSI prevention across a variety of surgical infection risk profiles.
C1 [Kerivan, Lauren T.; Hill, Terra M.; Guidry, Christopher A.] Univ Kansas Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
   [Vilain, Katherine A.] St Lukes Hosp Cardiovasc & Cardiothorac Res, Kansas City, MO USA.
C3 University of Kansas; University of Kansas Medical Center
RP Guidry, CA (通讯作者)，Univ Kansas Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
EM cguidry2@kumc.edu
RI Kerivan, Lauren/NBX-4693-2025; Guidry, Christopher/GRS-5109-2022
OI Kerivan, Lauren/0009-0002-7648-2678; 
CR Acker A, 2018, J SURG RES, V232, P450, DOI 10.1016/j.jss.2018.05.083
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NR 35
TC 2
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD AUG 1
PY 2025
VL 26
IS 6
BP 413
EP 419
DI 10.1089/sur.2024.286
EA MAR 2025
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 5PZ8Z
UT WOS:001447449600001
PM 40106232
DA 2026-07-24
ER

PT J
AU Ivert, T
   Berge, A
   Bratt, S
   Dalén, M
AF Ivert, Torbjorn
   Berge, Andreas
   Bratt, Sorosh
   Dalen, Magnus
TI Incidence and healing times of postoperative sternal wound infections: a
   retrospective observational single-centre study
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE Superficial sternal wound infection; mediastinitis; negative pressure
   wound therapy
ID OPEN-HEART-SURGERY; RISK-FACTORS; DEEP; COMPLICATIONS; MEDIASTINITIS;
   MANAGEMENT
AB Objectives: Analyses of incidence and time required to heal sternal wound infections after heart surgery performed via a median sternotomy between 2020 and 2022. Results: Superficial wound infections (SWI) were five times more common (2.7%) than mediastinitis (0.5%) among 2693 patients. The median time between the operation and diagnosis of SWI was 26 (interquartile range [IQR] 15-33) days vs. 16 (IQR 9-25) days for mediastinitis (p = .12). Gram-negative bacteria caused 44% of the 85 infections. Sternal wound infection correlated to higher body mass index, female sex, smoking, diabetes mellitus, previous myocardial infarction, coronary artery bypass grafting, use of internal mammary graft, and re-entry for postoperative bleeding. Eight of 59 patients (13.6%) with sternal wound infections had bilateral mammary grafts, compared to 102 of 1191 patients (8.6%) without wound infections (p = .28). Negative pressure wound therapy was always used to treat mediastinitis and applied in 63% of patients with SWI. Two of 13 patients with mediastinitis (15%) and none of 72 patients with SWI died within 90 days after the operation. The median time until the wound healed was 1.9 (IQR 1.3-3.7) months after SWI vs. 1.7 (IQR 1.3-5.3) months after mediastinitis (p = .63). Six patients (7%) required longer than one year to treat the infection. Conclusions: Postoperative sternal wound infections usually appeared several weeks after surgery and were associated with factors as high body mass index, diabetes mellitus and coronary artery bypass. SWI were more common than mediastinitis and often required negative pressure wound therapy and similar treatment time as mediastinitis.
C1 [Ivert, Torbjorn; Bratt, Sorosh; Dalen, Magnus] Karolinska Univ Hosp, Dept Cardiothorac Surg, Eugeniavagen 23,C12 28, S-17176 Stockholm, Sweden.
   [Ivert, Torbjorn; Bratt, Sorosh; Dalen, Magnus] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Berge, Andreas] Karolinska Inst, Dept Med, Unit Infect Dis, Stockholm, Sweden.
   [Berge, Andreas] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska
   University Hospital
RP Ivert, T (通讯作者)，Karolinska Univ Hosp, Dept Cardiothorac Surg, Eugeniavagen 23,C12 28, S-17176 Stockholm, Sweden.
EM torbjorn.ivert@ki.se
RI B, Andreas/KEI-3902-2024
FU Fredrik Lundberg
FX No Statement Available
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NR 21
TC 4
Z9 7
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD DEC 31
PY 2024
VL 58
IS 1
AR 2330349
DI 10.1080/14017431.2024.2330349
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LN7Q7
UT WOS:001187552100001
PM 38500294
OA Bronze
DA 2026-07-24
ER

PT J
AU Hill, R
AF Hill, Richard
TI Using Augmented Reality to Improve Patient Outcomes With Negative
   Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE quality improvement; augmented reality; digital technology; negative
   pressure wound therapy
AB Introduction. Augmented reality (AR) is a burgeoning digital technology that is finding more frequent use in health care. The benefits of AR, such as hands-free imaging and remote viewing, make this a tool particularly suited to wound care. To the author's knowledge, no attempts have been made to leverage this technology in a way that might improve patient outcomes. Similarly, few studies on remote wound consultation focus on the inpatient setting. Objective. This study demonstrated the use of AR to improve the outcome of patients undergoing negative pressure wound therapy. Materials and Methods. A case-control study of 27 patients treated in a rural Louisiana hospital was performed. A retrospective control group (n = 15) was identified and compared with similar cases (n = 12) that used AR by the bedside nursing staff and an offsite certified wound care clinician. Results. At univariate analysis, the treatment group was found to have fewer unintended surgical revisions (P =.002), fewer interruptions in therapy time (P =.01), and fewer readmissions related to wound infection (P =.004) compared with the control group. Correlational testing was performed and showed a significant correlation between the number of dressings performed and the number of complications that arose (0.71) as well as between premature dressing removals and number of readmissions related to infection (0.74). Conclusions. The results of this study, although preliminary, show how AR can be used in the acute care setting to positively influence outcomes of patients undergoing wound care. Further testing is necessary to replicate these findings and assess the use of AR with other advanced modalities or for other indications in the acute care setting.
C1 [Hill, Richard] Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
RP Hill, R (通讯作者)，Natchitoches Reg Med Ctr, 501 Keyser Ave, Natchitoches, LA 71457 USA.
EM hill.richardb@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bugeja L, 2018, INT WOUND J, V15, P880, DOI 10.1111/iwj.12940
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NR 8
TC 4
Z9 4
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2022
VL 34
IS 2
BP 47
EP 50
DI 10.25270/wnds/2022.4750
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YV3YQ
UT WOS:000752667100002
PM 35108668
DA 2026-07-24
ER

PT J
AU Porfidia, R
   Grimaldi, S
   Ciolli, MG
   Picarella, P
   Grimaldi, S
AF Porfidia, Raffaele
   Grimaldi, Simona
   Ciolli, Maria Giovanna
   Picarella, Pietro
   Grimaldi, Sergio
TI The Pivotal Role of Negative Pressure Wound Therapy in the Management of
   Enteroatmospheric Fistula: A Year-Long "Obstacle Marathon
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE malnutrition; negative pressure wound therapy; open abdomen; enteral
   stent; enteroatmospheric fistula
AB Background. Enteroatmospheric fistula (EAF) is an abnormal communication between the gastrointestinal tract and the atmosphere. This phenomenon is still considered one of the most significant challenges faced by general surgeons after abdominal surgery. Primary goals of managing EAF include controlling and diverting intestinal contents outside the abdominal cavity, protecting surrounding tissues from retraction, and promoting wound healing. Achieving these goals is not easy. EAF has a 40% mortality rate. Several techniques have been proposed for managing this problem, including negative pressure wound therapy. The use of bladder catheters, nipples, endoscopic stents, vascular grafts, and fistula funnel, among other options, in the management of EAF has also been described. Case Report. The patient in the current report underwent Hartmann reversal surgery. On postoperative day (POD) 5, he had an anastomotic leak with ischemia of the descending colon and the transverse colon. Resection of the ischemic colon was performed, followed by creation of a terminal ileostomy on the last ileal loop on the right side. The first small orifice of EAF appeared on POD 23, the second on POD 28, and the third on POD 45. On POD 253, the patient underwent resection of the fistulated loop, extensive vitreolysis of the entire small intestine, and mechanical jejunojejunal laterolateral anastomosis to reestablish the canalization toward the previous terminal ileostomy on the right side. Complete closure of the skin was evident on POD 358. Conclusion. There is no ideal treatment approach that is valid for all cases of EAF. Spontaneous closure of an EAF is unlikely but feasible in the setting of a single, deep lesion with limited output and when intestinal continuity is preserved.
C1 [Porfidia, Raffaele; Ciolli, Maria Giovanna; Picarella, Pietro; Grimaldi, Sergio] Casa Cura Villa Fiori, Naples, Italy.
   [Grimaldi, Simona] Univ Milan La Statale, Milan, Italy.
RP Porfidia, R (通讯作者)，Casa Cura Villa Fiori, Gen & Oncol Surg, Corso Italia 157, I-80011 Naples, Italy.
EM dottoreporfidia@gmail.com
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NR 12
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2024
VL 36
IS 9
BP 316
EP 322
DI 10.25270/wnds/24035
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA J7T5B
UT WOS:001339049400005
PM 39378350
DA 2026-07-24
ER

PT J
AU Jorgensen, MG
   Toyserkani, NM
   Thomsen, JB
   Sorensen, JA
AF Jorgensen, Mads Gustaf
   Toyserkani, Navid Mohamadpour
   Thomsen, Jorn Bo
   Sorensen, Jens Ahm
TI Prophylactic incisional negative pressure wound therapy shows promising
   results in prevention of wound complications following inguinal lymph
   node dissection for Melanoma: A retrospective case-control series
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Lymphadenectomy; Prevention; Incisional negative pressure wound therapy;
   Seroma; Surgical wound infection; Lymphedema
ID METAANALYSIS
AB Background: Inguinal lymphadenectomy (ILND) for melanoma is associated with a number of complications including seroma, surgical site infection (SSI), and lymphedema. Incisional negative pressure wound therapy (iNPWT) has shown promising results in preventing postoperative morbidity across a wide variety of surgical procedures, but these results are yet to be investigated in patients undergoing ILND for melanoma.
   Methods: In this study, we reviewed the data of 55 melanoma patients treated with ILND between January 2015 and January 2017 at Odense University Hospital. Patients were followed up until April 2018 for the occurrence of seroma, SSI, and lymphedema. We used prophylactic iNPWT after ILND in 14 patients and compared their morbidity outcomes with the 41 patients receiving standard postoperative wound care in the same period.
   Results: The iNPWT intervention significantly reduced seroma compared to the control group (28.6% vs. 90.3%, p < 0.001) and had a trending impact on wound infection (42.9% vs. 65.9%, p = 0.13). The effect was not significant for the prevention of lymphedema (35.7% vs. 51.2%, p = 0.33). Because the iNPWT group had relatively fewer incidences of seroma, SSI, and lymphedema, the iNPWT intervention was more cost-effective than conventional wound care (US$911.2 vs. US$ 2542.7, p < 0.05).
   Conclusion: The use of prophylactic iNPWT significantly reduced seroma formation following ILND. These promising results, however, need to be confirmed in a future prospective randomized trial. (C) 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.
C1 [Jorgensen, Mads Gustaf; Thomsen, Jorn Bo; Sorensen, Jens Ahm] Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
   [Toyserkani, Navid Mohamadpour] Roskilde Hosp, Dept Plast Surg, Sygehusvej 10, DK-4000 Roskilde, Denmark.
C3 University of Southern Denmark; Odense University Hospital
RP Sorensen, JA (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
EM jens.sorensen@rsyd.dk
RI Sørensen, Jens Ahm/D-6279-2014
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Thomsen, Jørn
   Bo/0000-0002-7368-6133; Jørgensen, Mads Gustaf/0000-0002-8755-3446
CR Abbas S, 2011, SURG ONCOL, V20, P88, DOI 10.1016/j.suronc.2009.11.003
   [Anonymous], 2018, DRG TAKSTER 2018
   [Anonymous], 2018, REGION SO DENMARK FA
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Cooper MA, 2015, J HEALTHC QUAL, V37, P133, DOI 10.1111/jhq.12036
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NR 24
TC 17
Z9 20
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2019
VL 72
IS 7
BP 1178
EP 1183
DI 10.1016/j.bjps.2019.02.013
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ID7XV
UT WOS:000471897100017
PM 30898502
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Horch, RE
   Braumann, C
   Dissemond, J
   Lehner, B
   Hirche, C
   Woeste, G
   Wozniak, G
   Wetzel-Roth, W
   Willy, C
AF Horch, Raymund E.
   Braumann, Chris
   Dissemond, Joachim
   Lehner, Burkhard
   Hirche, Christoph
   Woeste, Guido
   Wozniak, Gernot
   Wetzel-Roth, Walter
   Willy, Christian
TI Use of Negative Pressure Wound Therapy with Instillation and Dwell Time
   for Wound Treatment - Results of an Expert Consensus Conference
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Review
DE wound infection; wound healing; wound debridement; vacuum-associated
   closure (for) wound dressing; vacuum instillation
ID INFECTIOUS-DISEASES SOCIETY; ANTIMICROBIAL SOLUTIONS; PREVENTION;
   INJURIES; CARE; GUIDELINES; MORTALITY; AMERICA
AB Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the heal-ing process. At the same time, it can aid in reducing the bacterial load in contaminated or infected wounds. Since this newer technique is now commercially available and increasingly widespread, recommendations for the proper use and clinical indications were developed by a panel of interdisciplinary experts in the course of a consensus meeting. Although the level of evidence from expert opinions is low, general guidelines for a safe and effective use of NPWTi-d can be worked out that can be of assistance to the clinician. The consensus recommendations derived from this meeting include the objectives of the treatment, the administration modalities of NPWTi-d, the indications for various wounds, including their contraindications, therapy settings, as well as the use of topical instillation solutions, volume and duration (dwell time) based on current scientific data, optimal treatment duration and future developments of the NPWTi-d.
C1 [Horch, Raymund E.] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Krankenhausstr 12, D-91054 Erlangen, Germany.
   [Braumann, Chris] Katholisches Klinikum Bochum, Klin Allgemein & Viszeralchirurg, St Josef Hosp, Bochum, Germany.
   [Dissemond, Joachim] Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Essen, Germany.
   [Lehner, Burkhard] Sekt Orthopad Onkol, Heidelberg, Germany.
   [Lehner, Burkhard] Klin Orthopad & Unfallchirurg, Heidelberg, Germany.
   [Hirche, Christoph] Heidelberg Univ, Luftrettungs Zentrum Rettungshubschrauber Christo, Klin Unfallchirurg & Orthopad,Ruprecht Karls Univ, Klin Unfallchirurg,Berufsgenossenschaftl Unfallkl, Ludwigshafen, Germany.
   [Woeste, Guido] Agaplesion Elisabethenstift gGmbH, Allgemein & Viszeralchirurg, Darmstadt, Germany.
   [Wozniak, Gernot] Knappschaftskrankenhaus Bottrop GmbH, Klin Gefasschirurg, Bottrop, Germany.
   [Wetzel-Roth, Walter] Wertachkliniken KH Schwabmunchen, Chirurg & Gefasschirurg, Buchloe, Germany.
   [Willy, Christian] Bundeswehrkrankenhaus Berlin, Unfallchirurg, Berlin, Germany.
C3 University of Erlangen Nuremberg; Ruhr University Bochum; University of
   Duisburg Essen; Ruprecht Karls University Heidelberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen, Plast & Handchirurg Klin, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Dissemond, Joachim/AFG-0691-2022; Hirche, Christoph/GYA-4981-2022;
   Horch, Raymund/H-8128-2019; /AAA-9828-2021; /AAJ-3174-2021
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NR 45
TC 18
Z9 23
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD DEC
PY 2018
VL 143
IS 6
BP 609
EP 616
DI 10.1055/a-0713-0517
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HD9DN
UT WOS:000452861200013
PM 30537781
DA 2026-07-24
ER

PT J
AU Tian, Y
   Liu, T
   Zhao, CQ
   Lei, ZY
   Fan, DL
   Mao, TC
AF Tian, Yuan
   Liu, Ting
   Zhao, Chuan-qi
   Lei, Ze-yuan
   Fan, Dong-li
   Mao, Tong-chun
TI Negative pressure wound therapy and split thickness skin graft aided in
   the healing of extensive perineum necrotizing fasciitis without faecal
   diversion: a case report
SO BMC SURGERY
LA English
DT Article
DE Perineum necrotizing fasciitis; Fournier gangrene; Negative pressure
   wound therapy; Skin graft; Faecal diversion
ID FOURNIERS-GANGRENE; MANAGEMENT; DRESSINGS; ULCERS
AB Background: Perineum necrotizing fasciitis, also known as Fournier gangrene (FG), is a rare but highly mortal infectious necrotizing fasciitis with or without involvement of the underlying muscle. Evidence exists that negative pressure wound therapy (NPWT) combined with a split thickness skin graft (STSG) can help to heal wounds with FG. However, when the wound spreads to the anal area, it can easily be contaminated by faeces, causing a more extensive wounds; thus, faecal diversion is considered. Here, we report a case of extensive perineum necrotizing fasciitis that spread to near the anus; NPWT combined with STSGs was used to help heal the wound without faecal diversion.
   Case presentation: A 47-year-old male patient was admitted with extensive perineum fascia necrosis caused by Pseudomonas aeruginosa that rapidly spread to near the anus. After comprehensive therapy completed wound bed preparation, STSGs from the scalp were grafted to the wound, and NPWT was applied to improve STSGs survival and seal the anus without faecal diversion.
   After treatment, graft take was 95%, and the exposed testicular and residual wounds were repaired with a local skin flap. At discharge, the wound had decreased to two pea-sized areas. The patient received conventional moist gauze therapy to close the residual wound at the local hospital. A follow-up by telephone 1 month later showed that both wounds had healed and that the patient was satisfied with the outcome.
   Conclusion: NPWT use combined with STSGs to cover the whole wound and the anus without faecal diversion is a safe and effective method to help with wound healing and avoid contamination with excrement.
C1 [Tian, Yuan; Liu, Ting; Zhao, Chuan-qi; Lei, Ze-yuan; Fan, Dong-li; Mao, Tong-chun] Army Med Univ, Dept Plast & Cosmet Surg, Xinqiao Hosp, Xinqiao Rd, Chongqing 400037, Peoples R China.
C3 Army Medical University
RP Mao, TC (通讯作者)，Army Med Univ, Dept Plast & Cosmet Surg, Xinqiao Hosp, Xinqiao Rd, Chongqing 400037, Peoples R China.
EM wei_dao1234@163.com
RI Tian, Yuan/IAN-7537-2023
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NR 14
TC 8
Z9 9
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD SEP 24
PY 2018
VL 18
AR 77
DI 10.1186/s12893-018-0411-6
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GU6WC
UT WOS:000445457100002
PM 30249225
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Timmermans, FW
   Mokken, SE
   Smit, JM
   Bouman, MB
   van de Grift, TC
   Mullender, MG
   Middelkoop, E
AF Timmermans, Floyd W.
   Mokken, Sterre E.
   Smit, Jan-Maerten
   Bouman, Mark-Bram
   van de Grift, Timotheus C.
   Mullender, Margriet G.
   Middelkoop, Esther
TI The impact of incisional negative pressure wound therapy on scar quality
   and patient-reported outcomes: A within-patient-controlled, randomised
   trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE gender reassignment surgery; mastectomy; negative pressure wound
   therapy; patient-reported outcome measure; scar; transgender; wound
   healing
ID SURGICAL WOUNDS; TRANSGENDER; MANAGEMENT; SURGERY; DEVICE; SKIN
AB Literature provides a moderate level of evidence for the beneficial effects of incisional negative pressure wound therapy (iNPWT) on scar quality. The purpose of this study was to establish if iNPWT results in improved scar outcomes in comparison to the standard of care. Therefore, a within-patient randomised controlled, open-label trial was conducted in transgender men undergoing gender-affirming mastectomies. A unilateral side was randomised to receive iNPWT (PICO (TM), Smith&Nephew) without suction drains and contrastingly the standard dressing (Steri-Strips (TM)) with suction drain. Scar quality and questionnaires were bilaterally measured by means of objective assessments and patient-reported outcome measures (PROM) at 1, 3 and 12 months. Objective scar outcomes were scar pliability (Cutometer (R)), colouration (DSM-II) and scar width (3-D imaging). PROM outcomes were related to scars (POSAS and SCAR-Q) and body satisfaction (BODY-Q). From 85 included patients, 80 were included for analyses. No significant difference between treatments was seen in the quantitative outcomes of scar pliability, colour, and width. For qualitative scar outcomes, several significant findings for iNPWT were found for several subscales of the POSAS, SCAR-Q, and BODY-Q. These effects could not be substantiated with linear mixed-model regression, signifying no statically more favourable outcome for either treatment option. In conclusion, this study demonstrated that some PROM outcomes were more favourable for the iNPWT compared to standard treatment. In contrast, the quantitative outcomes showed no beneficial effects of iNPWT on scar outcomes. This suggests that iNPWT is of little benefit as a scar-improving therapy.
C1 [Timmermans, Floyd W.; Mokken, Sterre E.; Smit, Jan-Maerten; Bouman, Mark-Bram; Mullender, Margriet G.; Middelkoop, Esther] Amsterdam UMC, Locat VUmc, Amsterdam Movement Sci, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
   [Timmermans, Floyd W.; Mokken, Sterre E.; Smit, Jan-Maerten; Bouman, Mark-Bram; van de Grift, Timotheus C.; Mullender, Margriet G.; Middelkoop, Esther] Amsterdam UMC, Locat VUmc, Ctr Expertise Gender Dysphoria, Amsterdam, Netherlands.
   [Bouman, Mark-Bram; van de Grift, Timotheus C.; Mullender, Margriet G.] Amsterdam UMC, Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Middelkoop, Esther] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam
RP Middelkoop, E (通讯作者)，Amsterdam UMC, Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
EM e.middelkoop@amsterdamumc.nl
RI ; Mullender, Margriet/PWH-3332-2026; Middelkoop, Esther/M-3735-2014
OI Mokken, Sterre/0000-0002-8891-969X; Bouman,
   Mark-Bram/0000-0002-4245-783X; Mullender, Margriet/0000-0001-6407-5405;
   Middelkoop, Esther/0000-0001-8843-1080
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NR 37
TC 9
Z9 11
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2022
VL 30
IS 2
BP 210
EP 221
DI 10.1111/wrr.13001
EA FEB 2022
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA ZL3MW
UT WOS:000758280500001
PM 35146830
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Tao, YX
   Zhang, YS
   Liu, Y
   Tang, SJ
AF Tao, Yixi
   Zhang, Yusui
   Liu, Yang
   Tang, Songjiang
TI 被撤回的出版物: Effects of negative pressure wound therapy on surgical site
   wound infections after cardiac surgery: A meta-analysis (Retracted
   article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE cardiac surgery; meta-analysis; negative pressure wound therapy; wound
   infection
ID OPEN-HEART-SURGERY; QUALITY
AB We conducted a comprehensive analysis to evaluate the benefits of negative pressure wound therapy (NPWT) versus traditional dressings in preventing surgical site infections in patients undergoing cardiac surgery. We thoroughly examined several databases, including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, Chinese Biomedical Literature Database (CBM) and Wanfang, from inception until July 2023. Two independent researchers were responsible for the literature screening, data extraction and quality assessment; analyses were performed using RevMan 5.4 software. Thirteen studies comprising 8495 patients were deemed relevant. A total of 2685 patients were treated with NPWT, whereas 5810 received conventional dressings. The findings revealed that NPWT was more effective in reducing surgical site infections after cardiac surgery than conventional dressings (4.88% vs. 5.87%, odds ratio [OR]: 0.50, 95% confidence intervals [CIs]: 0.40-0.63, p < 0.001). Additionally, NPWT was more effective in reducing deep wound infections (1.48% vs. 4.15%, OR: 0.36, 95% CI: 0.23-0.56, p < 0.001) and resulted in shorter hospital stays (SMD: -0.33, 95% CIs: -0.54 to -0.13, p = 0.001). However, the rate of superficial wound infections was not significantly affected by the method of wound care (3.72% vs. 5.51%, OR: 0.63, 95% CI: 0.32-1.23, p = 0.180). In conclusion, NPWT was shown to be advantageous in preventing postoperative infections and reducing hospital stay durations in patients undergoing cardiac surgery. Nonetheless, given the limitations in the number and quality of the included studies, further research is recommended to validate these findings.
C1 [Tao, Yixi] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiovasc Med, Guiyang, Peoples R China.
   [Zhang, Yusui] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Intervent Surg Radiol, Guiyang, Peoples R China.
   [Liu, Yang] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Sci Res Div, Guiyang, Peoples R China.
   [Tang, Songjiang] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Anaesthesia, Guiyang, Peoples R China.
   [Tao, Yixi] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiovasc Med, Guiyang 550001, Guizhou, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Guizhou University
   of Traditional Chinese Medicine; Guizhou University of Traditional
   Chinese Medicine; Guizhou University of Traditional Chinese Medicine;
   Guizhou University of Traditional Chinese Medicine
RP Tao, YX (通讯作者)，Guizhou Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiovasc Med, Guiyang 550001, Guizhou, Peoples R China.
EM taoyx870125@163.com
CR Bigdeli AK, 2022, J PERS MED, V12, DOI 10.3390/jpm12030427
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NR 30
TC 4
Z9 6
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2024
VL 21
IS 2
DI 10.1111/iwj.14398
EA SEP 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JB0W4
UT WOS:001071780700001
PM 37740679
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, ZS
   Tian, SB
AF Liu, Zhi-Shen
   Tian, Shao-Bin
TI 被撤回的出版物: Influence of closed-incision negative-pressure wound therapy on
   the incidence of surgical site wound infection in patients undergoing
   spine surgery: A meta-analysis (Retracted article. See vol. 21, 2024)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE closed incision; meta; negative-pressure wound therapy; spine surgery;
   wound infection
ID DEHISCENCE; FUSION
AB The present meta-analysis was conducted to comprehensively assess the impact of closed-incision negative-pressure wound therapy (ciNPWT) on the incidence of surgical site infections (SSIs) in patients undergoing spinal fusion surgery, thereby aiming to provide evidence-based support for the prevention of postoperative wound infections during spinal surgery. Relevant studies pertaining to the application of ciNPWT in spinal surgery were retrieved through searches of the PubMed, Embase, MEDLINE and Cochrane Library databases, spanning from their inception to May 2023. The literature screening and data extraction were performed by two researchers based on predefined inclusion and exclusion criteria, followed by a quality assessment of the included studies. Meta-analyses were performed using the odds ratios (ORs) and standardised mean differences (SMDs) as effect variables. RevMan 14.0 and STATA 17.0 were employed for meta-analysis of the extracted data. In total, eight articles involving 1198 patients, including 391 in the experimental group and 807 in the control group, were included. The meta-analysis results revealed that ciNPWT significantly reduced the incidence of SSIs in patients undergoing spinal fusion surgery (OR, 0.39; 95% CI: 0.22-0.67, p = 0.0007); however, it did not lead to a reduction in hospital stay duration (SMD: -0.48, 95% CI: -0.98 to 0.01, p = 0.06). Existing evidence suggests that ciNPWT has a positive impact on patients undergoing spinal fusion surgery, as it significantly reduces the incidence of postoperative surgical site wound infections; however, it does not result in a shorter hospital stay for patients.
C1 [Liu, Zhi-Shen; Tian, Shao-Bin] Jincheng Gen Hosp, Dept Orthoped, Jincheng 048006, Shanxi, Peoples R China.
C3 Shanxi Medical University
RP Tian, SB (通讯作者)，Jincheng Gen Hosp, Dept Orthoped, Jincheng 048006, Shanxi, Peoples R China.
EM shaobintian2093@163.com
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
   Akhter AS, 2021, INT WOUND J, V18, P158, DOI 10.1111/iwj.13507
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   Crist BD, 2017, INJURY, V48, P1518, DOI 10.1016/j.injury.2017.04.055
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NR 24
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2023
VL 20
IS 10
BP 4193
EP 4199
DI 10.1111/iwj.14317
EA JUL 2023
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CH3W9
UT WOS:001040314000001
PM 37518769
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, CB
   Xie, HT
   Wei, P
   Gong, T
   Wu, GH
   Xu, ZR
   Chen, S
AF Liu, Canbin
   Xie, Hongteng
   Wei, Pei
   Gong, Teng
   Wu, Guohua
   Xu, Zhaorong
   Chen, Shun
TI Clinical study of early rehabilitation training combined with negative
   pressure wound therapy for the treatment of deep partial-thickness hand
   burns
SO FRONTIERS IN SURGERY
LA English
DT Article
DE hand burn; negative pressure wound therapy; total active motion; brief
   Michigan Hand Function profiles; early rehabilitation training
ID EARLY MOBILIZATION PROTOCOL; MANAGEMENT; INJURIES; MOBILITY; IMPACT; ICU
AB ObjectiveThis study aims to explore the clinical effect of early rehabilitation training combined with negative pressure wound therapy (NPWT) for treating deep partial-thickness hand burns. MethodsTwenty patients with deep partial-thickness hand burns were randomly divided into an experimental group (n = 10) and a control group (n = 10). In the experimental group, early rehabilitation training combined with NPWT was performed, including the proper sealing of the negative pressure device, intraoperative plastic brace, early postoperative exercise therapy during negative pressure treatment, and intraoperative and postoperative body positioning. Routine NPWT was conducted in the control group. Both groups received 4 weeks of rehabilitation after wounds healed by NPWT with or without skin grafts. Hand function was evaluated after wound healing and 4 weeks after rehabilitation, including hand joint total active motion (TAM) and the brief Michigan Hand Questionnaire (bMHQ). ResultsTwenty patients were involved in this study, including 16 men and 4 women, aged 18-70 years, and the hand burn area ranged from 0.5% to 2% of the total body surface area (TBSA). There was no significant difference in TAM and bMHQ scores between the two groups after negative pressure removal. After 4 weeks of rehabilitation training, the TAM scores and bMHQ scores were significantly improved in both groups (p < 0.05); among them, those of the experimental group were both significantly better than those of the control group (p < 0.05). ConclusionThe application of early rehabilitation training combined with NPWT to treat deep partial-thickness hand burns can effectively improve hand function.
C1 [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Burn Med Ctr, Union Hosp, Fuzhou, Peoples R China.
   [Liu, Canbin; Xie, Hongteng; Wei, Pei; Gong, Teng; Wu, Guohua; Xu, Zhaorong; Chen, Shun] Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University; Fujian Medical University
RP Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Burn & Wound Repair Dept, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Burn Inst, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Burn Med Ctr, Union Hosp, Fuzhou, Peoples R China.; Xu, ZR; Chen, S (通讯作者)，Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou, Peoples R China.
EM fjchenshun@126.com; 234828306@qq.com
RI Gong, Teng/AIA-3355-2022
FU High-level Hospital and Clinical Specialty Discipline Construction
   Programme for Fujian Medical Development, China [[2021]76]; Fujian
   Provincial Key Laboratory of Burn and Trauma, China; National Natural
   Science Foundation of China [82002034]
FX This work was supported by the High-level Hospital and Clinical
   Specialty Discipline Construction Programme for Fujian Medical
   Development, China ([2021]76) and Fujian Provincial Key Laboratory of
   Burn and Trauma, China. This work was also supported by the National
   Natural Science Foundation of China (Grant No. 82002034).
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   Zhou YQ, 2021, WORLD J CLIN CASES, V9, P9741, DOI 10.12998/wjcc.v9.i32.9741
NR 32
TC 4
Z9 5
U1 2
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 8
PY 2023
VL 10
AR 1040407
DI 10.3389/fsurg.2023.1040407
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9G7PE
UT WOS:000938339500001
PM 36843993
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cikirikcioglu, M
   Ponchant, K
   Murith, N
   Meyer, P
   Yilmaz, N
   Huber, C
AF Cikirikcioglu, Mustafa
   Ponchant, Kevin
   Murith, Nicolas
   Meyer, Philippe
   Yilmaz, Nurcan
   Huber, Christoph
TI Treatment of HeartMate III-LVAD driveline infection by negative pressure
   wound therapy: Result of our case series
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Device-related infection; left ventricular assist devices; driveline
   infections; heart failure; negative pressure wound therapy; HeartMate
   III
ID ASSIST; MANAGEMENT
AB Driveline infection is one of the most frequent complications following left ventricular assist device (LVAD) treatment and there is no consensus for its management. The standard approach to treat foreign-body infection is complete device ablation, which is not always feasible and therefore not an elected method for LVAD driveline infections. Here we share the results from a series of cases successfully treated for driveline infection by negative pressure wound therapy (NPWT) therapy. Between 2016 and 2020, five male patients were hospitalized in our unit with a driveline infection of HeartMate III-LVAD(R). Ultrasonography and/or thoraco-abdominal CT confirmed the diagnosis, infection localization, and abscess formation. Following an antibiotic treatment, an urgent surgical abscess drainage and debridement of the infected tissues were performed. At the end of the procedure, NPWT was applied. NPWT re-dressing and debridement of wound was performed every 3-4 days. The wound was closed surgically after obtaining negative culture results and good healing. The patients were discharged in good condition, without signs of infection. Two patients underwent successful heart transplantation after 1 and 13 months. Other patients did not show any residual or recurrent infection during the follow-up within 25 months. Driveline infection following LVAD implantation is a significant complication and a challenging in terms of management for both; the surgical team and the patient. These results from our case series report a successful and less invasive approach by using NPWT for the treatment of LVAD driveline infections.
C1 [Cikirikcioglu, Mustafa; Ponchant, Kevin; Murith, Nicolas; Yilmaz, Nurcan; Huber, Christoph] Univ Hosp, Div Cardiovasc Surg, Dept Surg, Geneva, Switzerland.
   [Cikirikcioglu, Mustafa; Ponchant, Kevin; Murith, Nicolas; Meyer, Philippe; Yilmaz, Nurcan; Huber, Christoph] Fac Med, Geneva, Switzerland.
   [Meyer, Philippe] Univ Hosp, Div Cardiol, Dept Internal Med, Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Cikirikcioglu, M (通讯作者)，Univ Hosp Geneva, Dept Surg, Div Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva, Switzerland.
EM mustafa.cikirikcioglu@hcuge.ch
RI Meyer, Philippe/HHC-0770-2022; Murith, Nicolas/IUN-4347-2023; Huber,
   Christoph/G-1141-2014; Yılmaz, Nurcan/KQU-5783-2024
OI Meyer, Philippe/0000-0002-2430-8953; Murith,
   Nicolas/0000-0002-7157-3880; Huber, Christoph/0000-0001-9048-849X; 
CR Akhter SA, 2015, ANN THORAC SURG, V100, P884, DOI 10.1016/j.athoracsur.2015.03.010
   Baradarian S, 2006, ASAIO J, V52, P354, DOI 10.1097/01.mat.0000204760.48157.cc
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   Saziye K, 2011, INT WOUND J, V8, P229, DOI 10.1111/j.1742-481X.2011.00773.x
   Sharma V, 2012, ANN THORAC SURG, V94, P1381, DOI 10.1016/j.athoracsur.2012.05.074
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   Vanden Eynden F, 2015, ANN TRANSL MED, V3, DOI 10.3978/j.issn.2305-5839.2015.11.30
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   Zierer A, 2007, ANN THORAC SURG, V84, P515, DOI 10.1016/j.athoracsur.2007.03.085
NR 15
TC 8
Z9 11
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD NOV
PY 2021
VL 44
IS 11
BP 912
EP 916
AR 03913988211047250
DI 10.1177/03913988211047250
EA SEP 2021
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA WP1FS
UT WOS:000703086000001
PM 34558333
OA Green Submitted, Green Published
DA 2026-07-24
ER

PT J
AU Tamir, E
   Finestone, AS
   Wiser, I
   Anekstein, Y
   Agar, G
AF Tamir, Eran
   Finestone, Aharon S.
   Wiser, Itay
   Anekstein, Yoram
   Agar, Gabriel
TI Outpatient Negative-Pressure Wound Therapy Following Surgical
   Debridement: Results and Complications
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE adverse events; amputation; diabetic foot ulcer; negative-pressure wound
   therapy; neuropathic foot ulcer; osteomyelitis; surgical debridement
ID RANDOMIZED CONTROLLED-TRIAL; FOOT; MULTICENTER; AMPUTATION; ULCERS; CARE
AB OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT).
   METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT.
   MAIN OUTCOME MEASURES: Wound area, closure rate, and adverse events.
   MAIN RESULTS: There were 66 patients provided NPWT in a total of 77 treatment courses. Mean patient age was 62 +/- 10 years, 82% were male, and mean diabetes mellitus duration was 14 +/- 8 years. Mean HbA1C levels were 8.1% +/- 1.7%. Mean treatment course duration was 16 days (range, 2-42 days). Wound area decreased significantly (from 11.3 +/- 16.8 cm(2) to 8.0 +/- 13.3 cm(2), P < .0001). Ulcer curing was noted in 7% of the cases, and healing progression was noted in 54%. Seven serious adverse events were recorded.
   CONCLUSIONS: Outpatient NPWT is a relatively safe and effective adjuvant to surgical debridement of neuropathic foot ulcers. In an outpatient setting, one can expect serious adverse events to occur in 10% of cases, but this seems unavoidable in patients with diabetic foot ulcers when taking into account their comorbidities and patient resources. Strict protocols to promote early recognition of complications and appropriate response to minimize deterioration must be implemented.
C1 [Tamir, Eran; Agar, Gabriel] Assaf Harofeh Med Ctr, Dept Orthoped, Zerifin, Israel.
   [Finestone, Aharon S.] Assaf Harofeh Med Ctr, Zerifin, Israel.
   [Wiser, Itay] Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol, Tel Aviv, Israel.
   [Anekstein, Yoram] Assaf Harofeh Med Ctr, Orthoped Surg Dept, Spine Unit, Zerifin, Israel.
C3 Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Tel Aviv
   University; Shamir Medical Center (Assaf Harofeh); Tel Aviv University;
   Sackler Faculty of Medicine; Shamir Medical Center (Assaf Harofeh); Tel
   Aviv University
RP Tamir, E (通讯作者)，Assaf Harofeh Med Ctr, Dept Orthoped, Zerifin, Israel.
RI Finestone, Aharon/R-9001-2019; Wiser, Itay/Q-2216-2019
OI Finestone, Aharon/0000-0003-1956-5557; 
CR Allahabadi S, 2016, DIABET FOOT ANKLE, V7, DOI 10.3402/dfa.v7.30079
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   Armstrong David G, 2004, Int J Low Extrem Wounds, V3, P12, DOI 10.1177/1534734604263291
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Barshes NR, 2016, INT J LOW EXTR WOUND, V15, P303, DOI 10.1177/1534734616661058
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Food and Drug Administration, 2011, UPD SER COMPL ASS NE
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   Lavery Lawrence A, 2014, J Diabetes Sci Technol, V8, P346
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   Ousey Karen, 2009, Br J Community Nurs, V14, pS8
   Ousey Karen, 2009, Br J Community Nurs, V14, ppassim
   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
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NR 24
TC 10
Z9 12
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2018
VL 31
IS 8
BP 365
EP 369
DI 10.1097/01.ASW.0000531352.93490.24
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GO4AJ
UT WOS:000439942000006
PM 29649067
DA 2026-07-24
ER

PT J
AU Qian, H
   Lei, T
   Hu, YH
AF Qian, Hu
   Lei, Ting
   Hu, Yihe
TI Negative pressure wound therapy versus gauze dressings in managing open
   fracture wound of lower limbs: A meta-analysis of randomized controlled
   trials
SO FOOT AND ANKLE SURGERY
LA English
DT Article
DE Open fracture; Negative pressure wound therapy; Standard gauze dressing;
   Meta-analysis; Randomized controlled trials
ID NPWT; INFECTION; TRAUMA
AB Background: The superiority of negative pressure wound therapy (NPWT) to standard gauze dressings for managing open fractures of the lower limbs remains controversial. This study aimed to comprehensively compare their clinical efficacy through a meta-analysis using randomized controlled trials (RCTs) alone. We hypothesized that NPWT would be more superior against infections.Methods: A literature search was implemented in various databases, including PubMed, Web of Science, Medline, Clinicaltrial.gov, and Cochrane Library, etc, to screen eligible RCTs. All included RCTs were eval-uated for risk of bias using the Cochrane Collaboration tool. In accordance with the heterogeneity assess-ment, a fixed-effect or random-effect model was chosen for the data analysis.Results: Ten RCTs, including 2780 patients, were eligible for the meta-analysis. We found that patients in the NPWT group showed a lower overall infection rate (MD=0.70, 95% CI: 0.54-0.90, P = 0.005), acute wound infection rate (MD = 0.35, 95% CI: 0.16-0.77, P = 0.009), and shorter hospital stay (MD = 24.00, 95% CI: 6.82-84.46, P < 0.00001) compared with the control group. The NPWT group showed a higher proportion of patients with wound coverage than the control group. No significant difference was found between the two groups in terms of function score and other complications, including deep infection rate, amputation, and bone nonunion.Conclusions: From the pooled results, we suggest that NPWT may be superior than traditional gauze dressings for managing open fractures of the lower limbs.(c) 2022 Published by Elsevier Ltd on behalf of European Foot and Ankle Society.
C1 [Qian, Hu; Lei, Ting; Hu, Yihe] Cent South Univ, Xiangya Hosp, Dept Orthopead Surg, Changsha, Peoples R China.
   [Hu, Yihe] Zhejiang Univ, Affliated Hosp 1, Coll Med, Dept Orthoped Surg, Hangzhou, Peoples R China.
   [Hu, Yihe] Hunan Engn Res Ctr Biomed Met & Ceram Implants, Changsha, Peoples R China.
   [Hu, Yihe] Cent South Univ, Xiangya Hosp, Dept Orthoped Surg, 87 Xiangya Rd, Changsha 410008, Peoples R China.
C3 Central South University; Zhejiang University; Central South University
RP Lei, T; Hu, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Orthopead Surg, Changsha, Peoples R China.; Hu, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Orthoped Surg, 87 Xiangya Rd, Changsha 410008, Peoples R China.
EM leiting19950415@gmail.com; csuyihehu@gmail.com
RI Lei, Ting/AAB-4274-2022
FU National Natural Science Foundation of China;  [81873988]
FX Funding This study was supported by the National Natural Science
   Foundation of China (Grant Nos. 81873988) .
CR Arti H, 2016, PAK J MED SCI, V32, P65, DOI 10.12669/pjms.321.8568
   Blum ML, 2012, J ORTHOP TRAUMA, V26, P499, DOI 10.1097/BOT.0b013e31824133e3
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NR 22
TC 10
Z9 13
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1268-7731
EI 1460-9584
J9 FOOT ANKLE SURG
JI Foot Ankle Surg.
PD OCT
PY 2022
VL 28
IS 7
BP 1120
EP 1128
DI 10.1016/j.fas.2022.03.012
EA SEP 2022
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 6J0RB
UT WOS:000886535900006
PM 35450789
DA 2026-07-24
ER

PT J
AU Mankarious, MM
   Eng, NL
   Portolese, AC
   Deutsch, MJ
   Lynn, P
   Kulaylat, AS
   Scow, JS
AF Mankarious, M. M.
   Eng, N. L.
   Portolese, A. C.
   Deutsch, M. J.
   Lynn, P.
   Kulaylat, A. S.
   Scow, J. S.
TI Closed-incision negative-pressure wound therapy reduces superficial
   surgical site infections after open colon surgery: an NSQIP Colectomy
   Study
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Surgical site infections; Negative-pressure wound therapy; Incisional
   wound vac; Colon surgery; Readmissions
ID ABDOMINAL INCISIONS; COLORECTAL SURGERY; RISK; METAANALYSIS; LAPAROTOMY;
   PREVENTION; PATIENT
AB Background: The use of closed-incision negative-pressure wound therapy (iNPWT) has increased in the last decade across surgical fields, including colectomy. Aim: To compare postoperative outcomes associated with use of iNPWT following open colectomy from a large national database. Methods: A retrospective review of patients who underwent operations from 2015 to 2020 was performed using the National Surgical Quality Improvement Program (NSQIP) Targeted Colectomy Database. Intraoperative placement of iNPWT was identified in patients undergoing open abdominal operations with closure of all wound layers including skin. Propensity score matching was performed to define a control group who underwent closure of all wound layers without iNPWT. Patients were matched in a 1:4 (iNPWT vs control) ratio and postoperative rates of superficial, deep and organ-space surgical site infection (SSI), wound disruption, and readmission. Findings: A matched cohort of 1884 was selected. Patients with iNPWT had longer median operative time (170 (interquartile range: 129-232) vs 161 (114-226) min; P<0.05). Compared to patients without iNPWT, patients with iNPWT experienced a lower rate of 30-day superficial incisional SSI (3% vs 7%; P<0.05) and readmissions (10% vs 14%; P<0.05). iNPWT did not decrease risk of deep SSI, organ-space SSI, or wound disruption. Conclusion: Although there is a slightly increased operative time, utilization of iNPWT in open colectomy is associated with lower odds of superficial SSI and 30-day readmission. This suggests that iNPWT should be routinely utilized in open colon surgery to improve patient outcomes. (c) 2024 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Mankarious, M. M.; Eng, N. L.; Portolese, A. C.] Penn State Univ, Coll Med, Dept Surg, Hershey, PA USA.
   [Deutsch, M. J.; Lynn, P.; Kulaylat, A. S.; Scow, J. S.] Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Scow, JS (通讯作者)，Penn State Univ, Coll Med, Dept Surg, Div Colon & Rectal Surg, 500 Univ Dr, Hershey, PA 17033 USA.
EM jscow@pennstatehealth.psu.edu
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   Ju MH, 2015, JAMA SURG, V150, P51, DOI 10.1001/jamasurg.2014.2891
   Korol E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083743
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   Meyer J, 2021, CLIN INFECT DIS, V73, pE3804, DOI 10.1093/cid/ciaa1203
   Murphy PB, 2019, ANN SURG, V270, P38, DOI 10.1097/SLA.0000000000003111
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NR 39
TC 2
Z9 3
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD MAR
PY 2024
VL 145
BP 187
EP 192
DI 10.1016/j.jhin.2024.01.005
EA FEB 2024
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA LG6U4
UT WOS:001185679800001
PM 38272123
DA 2026-07-24
ER

PT J
AU Hasselmann, J
   Björk, J
   Svensson-Björk, R
   Acosta, S
AF Hasselmann, Julien
   Bjork, Jonas
   Svensson-Bjork, Robert
   Acosta, Stefan
TI Inguinal Vascular Surgical Wound Protection by Incisional Negative
   Pressure Wound Therapy A Randomized Controlled Trial-INVIPS Trial
SO ANNALS OF SURGERY
LA English
DT Article
DE negative pressure wound therapy; NPWT; surgical site infection; SSI;
   vascular surgery; groin
ID SITE INFECTIONS; MANAGEMENT; PREVENTION
AB Objective: A randomized controlled trial (RCT) was undertaken to determine the effect of negative pressure wound therapy (NPWT) on closed incisions after inguinal vascular surgery regarding surgical site infections (SSIs) and other wound complications. Background: SSIs are a major concern in open vascular procedures involving the inguinal region. Prophylactic NPWT on closed incisions has shown promising results, but the quality of evidence can be debated. This study aims to objectively evaluate whether NPWT on sutured inguinal incisions after elective vascular surgery can decrease the incidence of surgical site complications. Methods: One hundred thirty-nine patients undergoing elective open vascular surgery with inguinal incisions received either NPWT or a standard dressing. Patients with bilateral incisions randomly received a dressing on one incision and the opposite dressing on the other. The primary endpoints were SSI or other wound complications at 3 months, assessed by wound care experts blinded to the treatment arm and using objective wound assessment criteria (ASEPSIS-score). Statistical analysis was performed on an intention-to-treat basis and obtained P values from analyses in the uni- and bilateral groups were combined to an overall P value using Fisher's method for combining P values. Results: The incidence of SSI was reduced in the NPWT group compared with the control group [11.9% vs 29.5% in the unilateral group (n = 120), 5.3% vs 26.3% in the bilateral group (n = 19), respectively; combined P = 0.02]. No differences regarding other surgical site complications were observed between the groups. Conclusion: NPWT on closed inguinal vascular surgical incisions in elective patients reduces the incidence of SSI.
C1 [Hasselmann, Julien; Svensson-Bjork, Robert; Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Hasselmann, Julien; Svensson-Bjork, Robert; Acosta, Stefan] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Bjork, Jonas] Lund Univ, Div Occupat & Environm Med, Lund, Sweden.
   [Bjork, Jonas] Lund Univ Hosp, Clin Studies Sweden, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Lund University; Skane University Hospital
RP Hasselmann, J (通讯作者)，Lund Univ, Dept Clin Sci, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM JNHasselmann@gmail.com
RI Hasselmann, Julien/C-1586-2015; Acosta, Stefan/JAX-3225-2023; Björk,
   Jonas/AFS-4819-2022; Hasselmann, Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Björk, Jonas/0000-0003-1883-2000;
   Hasselmann, Julien/0000-0003-4453-0292; Svensson-Björk,
   Robert/0000-0003-1907-9022
FU Skane County (Region Skane); Skane University Hospital; Hulda Almroth
   foundation; Smith and Nephew
FX The trial has been funded by public Swedish funds stemming from Skane
   County (Region Skane), the Skane University Hospital, and the Hulda
   Almroth foundation since 2015 adding up to a total of 2.81 million SEK
   (about 311,000 USD). In addition, the research group received an
   unrestricted unconditional research grant of 15,550 USD and a donation
   of 100 PICO dressing kits from Smith and Nephew in 2013.
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   WILSON APR, 1986, LANCET, V1, P311
NR 20
TC 44
Z9 45
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2020
VL 271
IS 1
BP 48
EP 53
DI 10.1097/SLA.0000000000003364
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LC0JF
UT WOS:000525016300014
PM 31283565
DA 2026-07-24
ER

PT J
AU Collins, J
AF Collins, Jessica
TI Surgical intervention and customised dressings in an extremity wound
   caused by necrotising fasciitis: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE injuries; limb function; necrotising fasciitis; negative pressure wound
   therapy; skin grafting; wounds
AB Necrotising fasciitis can result in extensive loss of soft tissue and limb function. Therefore, surgical intervention requires a balance between extensive tissue removal and saving the limb. A 56-year-old male presented with necrotising fasciitis of the upper extremity. Debridement resulted in a full-thickness wound of the forearm and upper arm, an exposed olecranon and two proximally-based skin flaps. Reconstruction required multiple debridements to optimise the wound for skin grafting and to obtain flap adherence to underlying tissues of the upper arm. Conventional dressings over the flaps proved unsuccessful. Therefore, a customised versatile dressing to address each area of the wound was developed. Negative pressure wound therapy (NPWT) was applied over the exposed muscle (no exposed bone or tendon) of the lower arm and anterior upper arm; a hydropolymer foam dressing covered the elbow region. Closed incision negative pressure wound therapy (ciNPT) was applied over the incision on the posterior upper arm. Ultimately, complete wound closure was achieved, with normal/near-normal range of motion for all joints of the affected limb. There was complete take of skin grafts on the wrist, lower arm and anterior upper arm. ciNPT was effective in holding the incision together and promoting healing of the posterior upper arm, and the hydropolymer foam dressing aided with healing and coverage of the elbow region. In this case, healing of a large, complex upper extremity wound and restored limb function were achieved following use of a combination of surgical techniques and customisation of wound therapy modalities.
C1 [Collins, Jessica] OasisMD Lifestyle Healthcare, Plast & Reconstruct Surg, San Diego, CA 92126 USA.
RP Collins, J (通讯作者)，OasisMD Lifestyle Healthcare, Plast & Reconstruct Surg, San Diego, CA 92126 USA.
EM jessicacollinsmd@gmail.com
CR Anaya DA, 2005, ARCH SURG-CHICAGO, V140, P151, DOI 10.1001/archsurg.140.2.151
   Angoules AG, 2007, INJURY, V38, pS19, DOI 10.1016/j.injury.2007.10.030
   [Anonymous], 2014, CURR PROB SURG, V51, P344, DOI 10.1067/j.cpsurg.2014.06.001
   [Anonymous], BR J COMMUNITY NURS
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   2011, BURNS, V37, P925, DOI DOI 10.1016/LBURNS.2011.05.013
   2015, PAK J MED SCI, V31, P95
   2004, PLAST RECONSTR SURG, V114, P917, DOI DOI 10.1097/01.PRS.0000133168.57199.E1
   2008, ORTHOP CLIN N AM, V39, P251, DOI DOI 10.1016/J.0C1.2007.12.009
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   2006, ANN SURG, V244, P700, DOI DOI 10.1097/01.SLA.0000217745.56657.E5
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   2008, AM SURG, V74, P809
NR 21
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2019
VL 28
IS 5
SU 5
BP S21
EP S27
DI 10.12968/jowc.2019.28.Sup5.S21
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HX5FS
UT WOS:000467426900004
PM 31067168
DA 2026-07-24
ER

PT J
AU De Rooij, L
   van Kuijk, SMJ
   van Haaren, ERM
   Janssen, A
   Vissers, YLJ
   Beets, GL
   van Bastelaar, J
AF De Rooij, L.
   van Kuijk, S. M. J.
   van Haaren, E. R. M.
   Janssen, A.
   Vissers, Y. L. J.
   Beets, G. L.
   van Bastelaar, J.
TI Negative pressure wound therapy does not decrease postoperative wound
   complications in patients undergoing mastectomy and flap fixation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SEROMA FORMATION; TISSUE GLUE; METAANALYSIS; INFECTIONS; PREVENTION;
   SUTURES
AB Patients and breast cancer surgeons are frequently confronted with wound complications after mastectomy. Negative pressure wound therapy (NPWT) is a promising technique for preventing wound complications after skin closure in elective surgery. However, a clinical study evaluating postoperative complications following the use of NPWT, focusing solely on closed incisions in patients undergoing mastectomy, has yet to be performed. Between June 2019 and February 2020, 50 consecutive patients underwent mastectomy with NPWT during the first seven postoperative days. This group was compared to a cohort of patients taking part in a randomized controlled trial between June 2014 and July 2018. Primary outcome was the rate of postoperative wound complications, i.e. surgical site infections, wound necrosis or wound dehiscence during the first three postoperative months. Secondary outcomes were the number of patients requiring unplanned visits to the hospital and developing clinically significant seroma (CSS). In total, 161 patients were analyzed, of whom 111 patients in the control group (CON) and 50 patients in the NPWT group (NPWT). Twenty-eight percent of the patients in the NPWT group developed postoperative wound complications, compared to 18.9% in the control group (OR=1.67 (95% CI 0.77-3.63), p=0.199). The number of patients requiring unplanned visits or developing CSS was not statistically significant between the groups. This study suggests that Avelle negative pressure wound therapy in mastectomy wounds does not lead to fewer postoperative wound complications. Additionally, it does not lead to fewer patients requiring unplanned visits or fewer patients developing clinically significant seromas.Trial registration: ClinicalTrials.gov number, NCT03942575. Date of registration: 08/05/2019.
C1 [De Rooij, L.; van Haaren, E. R. M.; Janssen, A.; Vissers, Y. L. J.; van Bastelaar, J.] Zuyderland Med Ctr, Dept Surg, Postbus 5500, NL-6130 MB Sittard, Netherlands.
   [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands.
   [Beets, G. L.] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg, Amsterdam, Netherlands.
   [Beets, G. L.] Univ Maastricht, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands.
C3 Maastricht University; Netherlands Cancer Institute; Maastricht
   University
RP De Rooij, L (通讯作者)，Zuyderland Med Ctr, Dept Surg, Postbus 5500, NL-6130 MB Sittard, Netherlands.
EM l.derooij@zuyderland.nl
RI Beets, Geerard/G-2682-2013; van Kuijk, Sander/AAH-3239-2021
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
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   Kostaras EK, 2014, SURG INFECT, V15, P679, DOI 10.1089/sur.2013.165
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   Strugala V, 2017, SURG INFECT, V18, P810, DOI 10.1089/sur.2017.156
   Tanaydin V, 2018, AESTHET PLAST SURG, V42, P927, DOI 10.1007/s00266-018-1095-0
   ten Wolde B, 2014, ANN SURG ONCOL, V21, P802, DOI 10.1245/s10434-013-3359-x
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   van Bastelaar J, 2018, BREAST CANCER RES TR, V167, P409, DOI 10.1007/s10549-017-4540-x
   van Bastelaar J, 2017, CLIN BREAST CANCER, V17, P316, DOI 10.1016/j.clbc.2017.01.005
   Watts R, 2015, JBI DATABASE SYST RE, V13, P1260
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 22
TC 19
Z9 21
U1 1
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 5
PY 2021
VL 11
IS 1
AR 9620
DI 10.1038/s41598-021-89036-3
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SK8IG
UT WOS:000656459200001
PM 33953312
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ma, J
   Zhang, X
AF Ma, Jia
   Zhang, Xin
TI The Impacts of Negative Pressure Wound Therapy on Patients with Cancer
   Surgical Wounds: Systematic Review and Meta-Analysis
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Review
DE surgical wound infection; cancer; patient readmission; negative-pressure
   wound therapy; seroma
ID SITE INFECTION; HIGH-RISK; SURGERY; COMPLICATIONS; LAPAROTOMY
AB Background: Cancer is a prevalent medical condition that frequently requires surgical intervention. As a result, the management of surgical wounds in cancer patients becomes a pivotal aspect of nursing care. This meta-analysis explores the effects of negative pressure wound therapy (NPWT), a cutting-edge wound management technique, on healing outcomes in cancer-related surgical wounds. Methods: This systematic review and meta-analysis included randomized clinical trials comparing NPWT with standard wound care in cancer patients. Key outcomes assessed were surgical site infection (SSI), seroma formation, and hospital readmission. Only trials that reported these outcomes in cancer-related surgical wounds were considered eligible. Results: A total of 10 randomized trials involving 1,322 patients with surgical wounds were included in the analysis. Across all cancer types, NPWT did not demonstrate statistically significant advantages compared to conventional wound care in reducing: Surgical site infections: p = 0.11; Seroma formation: p = 0.38; Hospital readmissions: p = 0.68. However, subgroup analysis revealed a notable exception: NPWT significantly reduced the incidence of surgical site infections in colorectal cancer patients (p = 0.0002). Conclusion: The findings suggest that NPWT may offer targeted benefits, particularly for colorectal cancer patients, by lowering the risk of postoperative infections. However, for other cancer types, NPWT did not demonstrate significant improvements in SSI, seroma, or hospital readmission rates compared to standard care. This highlights the need for further research to determine the contexts in which NPWT can be most beneficial in cancer wound management.
C1 [Ma, Jia] Hangzhou Canc Hosp, Dept Comprehens Care, Hangzhou 310002, Zhejiang, Peoples R China.
   [Zhang, Xin] HangZhou Canc Hosp, Dept Radiat Oncol, Hangzhou 310002, Zhejiang, Peoples R China.
RP Zhang, X (通讯作者)，HangZhou Canc Hosp, Dept Radiat Oncol, Hangzhou 310002, Zhejiang, Peoples R China.
EM zhangxin12345abc@outlook.com
CR Abd El Aziz MA, 2021, AM J SURG, V222, P20, DOI 10.1016/j.amjsurg.2020.12.012
   Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
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NR 23
TC 1
Z9 1
U1 1
U2 1
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD APR
PY 2025
VL 19
IS 2
BP 64
EP 69
DI 10.6890/IJGE.202504_19(2).0001
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 2JI9T
UT WOS:001484040500004
DA 2026-07-24
ER

PT J
AU Nuhiji, E
AF Nuhiji, Edin
TI Trends and Innovation in Negative Pressure Wound Therapy: A Review of
   Burn Wound Management
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE burns; negative pressure wound therapy; negative pressure with
   instillation and dwell time; wound bed preparation; review
ID ASSISTED CLOSURE DEVICE; INITIAL-EXPERIENCE; CARE
AB Significance: Burns result in irretrievable cell damage, which can occur upon exposure to hot surfaces, liquids, gases, ultraviolet or ionizing radiation, and through friction. Standard of care in burn management involves protecting the patient, limiting burn progression, and achieving wound closure. Negative pressure wound therapy (NPWT) and NPWT with instillation and dwell time (NPWTi-d) are two wound management options that have been shown to improve outcomes for burn patients in recent years. This work provides a general review of NPWT and NPWTi-d use in burn wound management. A literature search was performed using PubMed and Embase for peer-reviewed publications and conference abstracts written in English and reporting on burn management using NPWT and/or NPWTi-d from a single manufacturer between 2000 and 2021. All burn types were included. Recent Advances: Thirteen studies and 308 patients were available for assessment. Use of NPWT was reported in a majority of studies (n = 11). When conventional NPWT was applied, graft take of >90% was observed and consistent final wound closure was achieved. Two studies described NPWTi-d use for burn wound management. NPWTi-d use promoted granulation tissue development in burn wounds. Critical Issues: Limited high-level prospective evidence exists for use of NPWT and NPWTi-d in burn wound management. Future Directions: Available literature on the use of NPWT and/or NPWTi-d in burn care has reported improved outcomes in wound bed preparation, which can ultimately lead to final wound closure. The use of these modalities should be considered in management of burn care patients.
C1 [Nuhiji, Edin] 3M Hlth Care, Global Med Sci, N Ryde, NSW, Australia.
   [Nuhiji, Edin] 3M Hlth Care, Global Med Sci, Bldg A,1 Rivett Rd, N Ryde, NSW 2113, Australia.
C3 3M; 3M
RP Nuhiji, E (通讯作者)，3M Hlth Care, Global Med Sci, Bldg A,1 Rivett Rd, N Ryde, NSW 2113, Australia.
EM enuhiji@mmm.com
OI Nuhiji, Edin/0009-0001-2376-376X
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NR 31
TC 11
Z9 13
U1 3
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2024
VL 13
IS 8
BP 391
EP 399
DI 10.1089/wound.2023.0114
EA DEC 2023
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA A7O0L
UT WOS:001152579200001
PM 37933900
OA hybrid
DA 2026-07-24
ER

PT J
AU Brozmanová, H
   Sistík, P
   Duricová, J
   Kacírová, I
   Kanková, K
   Kolek, M
AF Brozmanova, Hana
   Sistik, Pavel
   Duricova, Jana
   Kacirova, Ivana
   Kankova, Klara
   Kolek, Martin
TI Liquid chromatography-tandem mass spectrometry methods for
   quantification of total and free antibiotic concentrations in serum and
   exudate from patients with post-sternotomy deep sternal wound infection
   receiving negative pressure wound therapy
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Total and free antibiotic concentration; Method validation; Serum;
   Exudate; Cardiac surgery; Negative pressure wound therapy
ID BETA-LACTAM ANTIBIOTICS; UHPLC-MS/MS METHOD; HUMAN PLASMA;
   ULTRAFILTRATION IMPACT; UNBOUND FRACTION; VANCOMYCIN; PIPERACILLIN;
   TAZOBACTAM; PHARMACOKINETICS; CIPROFLOXACIN
AB Background: Systemically administered antibiotics are thought to penetrate the wounds more effectively during negative pressure wound therapy (NPWT).To test this hypothesis total and free antibiotic concentrations were quantified in serum and wound exudate.
   Methods: UHPLC-MS/MS methods were developed and validated for the determination of ceftazidime, cefepime, cefotaxime, cefuroxime, cefazolin, meropenem, oxacillin, piperacillin with tazobactam, clindamycin, ciprofloxacin, sulfamethoxazole/trimethoprim (cotrimoxazole), gentamicin, vancomycin, and linezolid. The unbound antibiotic fraction was obtained by ultrafiltration using a Millipore Microcon-30kda Centrifugal Filter Unit. Analysis was performed on a 1.7-mu m Acquity UPLC BEH C18 2.1 x 100-mm column with a gradient elution.
   Results: The validation was performed for serum, exudates and free fractions. For all matrices, requirements were met regarding linearity, precision, accuracy, limit of quantitation, and matrix effect. The coefficient of variation was in the range of 1.2-13.6%.and the recovery 87.6-115.6%, respectively. Among the 29 applications of antibiotics thus far, including vancomycin, clindamycin, ciprofloxacin, oxacillin, cefepime, cefotaxime, cotrimoxazole, and gentamicin, total and free antibiotic concentrations in serum and exudate were correlated.
   Conclusion: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.
C1 [Brozmanova, Hana; Sistik, Pavel; Duricova, Jana; Kacirova, Ivana] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
   [Brozmanova, Hana; Sistik, Pavel; Duricova, Jana; Kacirova, Ivana] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Syllabova 19, Ostrava 70300, Czech Republic.
   [Kankova, Klara; Kolek, Martin] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Syllabova 19, Ostrava 70300, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; University of
   Ostrava
RP Sistík, P (通讯作者)，Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, 17 Listopadu 1790, Ostrava 70852, Czech Republic.
RI Kolek, Martin/D-4115-2018; Brozmanova, ./G-9793-2019
OI Kolek, Martin/0000-0002-0418-3006; 
FU MH CZ-DRO [FNOs/2021]
FX Supported by by MH CZ-DRO (FNOs/2021) .
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   SUKL Prehled leciv, about us
   Wong G, 2013, ANTIMICROB AGENTS CH, V57, P6165, DOI 10.1128/AAC.00951-13
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NR 44
TC 8
Z9 8
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 1
PY 2024
VL 554
AR 117704
DI 10.1016/j.cca.2023.117704
EA JAN 2024
PG 10
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IP4F4
UT WOS:001167513100001
PM 38185284
DA 2026-07-24
ER

PT J
AU Chen, Z
   Sun, J
   Yao, ZP
   Song, CY
   Liu, WG
AF Chen, Zhi
   Sun, Jun
   Yao, Zhipeng
   Song, Chenyang
   Liu, Wenge
TI Can prophylactic negative pressure wound therapy improve clinical
   outcomes in spinal fusion surgery? A meta-analysis
SO EUROPEAN SPINE JOURNAL
LA English
DT Review
DE Negative pressure wound therapy; Prophylaxis; Postoperative
   complication; Spine surgery; Meta-analysis
ID SURGICAL SITE INFECTION; DEHISCENCE; QUALITY; TRIALS
AB Purpose Recently negative pressure wound therapy (NPWT) is increasingly being prophylactically used to prevent wound complications in various types of surgeries, but its role in spinal fusion surgery was less well established. This study aimed to evaluate the efficacy of prophylactic NPWT (PNPWT) usage in spinal fusion surgery. Methods Following PRISMA guidelines, databases PubMed, Embase and Web of Science were searched for relevant studies. Studies comparing PNPWT with standard wound dressing (SWD) were included and analyzed. The primary outcome was the incidence of surgical site infection, and secondary outcomes were incidence of wound dehiscence, overall wound complication, readmission and reoperation. Results A total of five studies were included; there were 279 patients in PNPWT group and 715 patients in SWD group. Four studies investigated surgical site infection; the pooled analysis showed a significantly lower incidence of surgical site infection in PNPWT group (OR: 0.399; 95% CI: 0.198, 0.802). Two studies explored wound dehiscence, three studies reported overall wound complication, and there were no significant differences between the two groups ((OR: 0.448; 95% CI: 0.144, 1.389) and (OR: 0.562; 95% CI: 0.296, 1.065), respectively). Two studies evaluated readmission, three studies compared reoperation rate, and the pooled results demonstrated no significant difference between the two groups ((OR: 1.045; 95% CI: 0.536, 2.038) and (OR: 0.979; 95% CI: 0.442, 2.169), respectively). Conclusions The current evidence suggested PNPWT could effectively reduce postoperative surgical site infection, but it had no significant benefit on reducing the incidence of wound dehiscence, overall wound complication, readmission and reoperation.
C1 [Chen, Zhi; Yao, Zhipeng; Song, Chenyang; Liu, Wenge] Fujian Med Univ Union Hosp, Dept Orthoped Surg, Fuzhou 350001, Fujian, Peoples R China.
   [Sun, Jun] Zhaotong Tradit Chinese Med Hosp, Dept Emergency, Zhaotong 657000, Yunnan, Peoples R China.
C3 Fujian Medical University
RP Liu, WG (通讯作者)，Fujian Med Univ Union Hosp, Dept Orthoped Surg, Fuzhou 350001, Fujian, Peoples R China.
EM lwgspine@126.com
RI Chen, Zhi/PKR-2689-2026; song, chenyang/KMA-2573-2024
OI Chen, Zhi/0000-0003-0099-0916; Liu, Wenge/0000-0003-2128-1908; Sun,
   Jun/0009-0006-1534-0122; 
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NR 20
TC 14
Z9 18
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0940-6719
EI 1432-0932
J9 EUR SPINE J
JI Eur. Spine J.
PD JUN
PY 2022
VL 31
IS 6
BP 1546
EP 1552
DI 10.1007/s00586-022-07178-y
EA MAR 2022
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 2D8IF
UT WOS:000770719200001
PM 35306599
DA 2026-07-24
ER

PT J
AU Maus, JC
   Hemal, K
   Khan, M
   Calder, BW
   Marks, MW
   Defranzo, AJ
   Pestana, IA
AF Maus, Jacob C.
   Hemal, Kshipra
   Khan, Mija
   Calder, Bennett W.
   Marks, Malcolm W.
   Defranzo, Anthony J.
   Pestana, Ivo Alexander
TI Dermal Regeneration Template and Staged Skin Grafting for Extirpative
   Scalp Wound Reconstruction: A 14-Year Experience
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE scalp reconstruction; scalp cancer reconstruction; Integra; cancer;
   scalp; dermal regeneration template; scalp; cranial burring; outer-table
   craniectomy; negative pressure wound therapy; scalp; periosteum; skin
   graft
ID ARTIFICIAL DERMIS; FREE FLAPS; DEFECTS; COMPLICATIONS; COVERAGE
AB Objective Dermal regeneration template and staged split-thickness skin grafting may mitigate the need for flap coverage of postoncologic scalp defects. This technique has been studied previously in small case series. We examine the effect of risk factors, surgical technique, irradiation, and dressing modalities on reconstructive outcomes in a highly comorbid patient cohort. Study Design Retrospective review. Setting Academic medical center. Methods Full- and partial-thickness extirpative scalp wounds reconstructed with dermal regeneration template and staged skin grafting were reviewed over a 14-year period. Stage 1 consisted of template application following burr craniectomy in cases lacking periosteum. Stage 2 consisted of skin grafting. Negative pressure wound therapy (NPWT) was variably used to support adherence. Results In total, 102 patients were analyzed (average age 74, mean follow-up 18 months). Eighty-one percent were American Society of Anesthesiologists class 3 or 4. Defect size averaged 56 cm(2). Average skin graft take was 94.5% in full-thickness wounds. Seven patients failed this method. Preoperative scalp irradiation was associated with major complication and delayed graft healing. Comorbidities, wound size, and burring were not associated with complication. Patients were more likely to heal with NPWT compared to bolster (hazard ratio, 1.67; 95% CI 1.01-2.77; P = .046). Time between stages was 6.6 days shorter when NPWT was applied (P < .001). Conclusion Dermal template and staged skin grafting is a reliable option for postcancer scalp reconstruction in poor flap candidates. Radiotherapy is associated with adverse outcomes. Negative pressure wound therapy simplifies postoperative wound care regimens and may accelerate healing.
C1 [Maus, Jacob C.; Khan, Mija; Calder, Bennett W.; Marks, Malcolm W.; Defranzo, Anthony J.; Pestana, Ivo Alexander] Wake Forest Baptist Med Ctr, Dept Plast & Reconstruct Surg, One Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Hemal, Kshipra] Wake Forest Sch Med, Winston Salem, NC 27101 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University
RP Pestana, IA (通讯作者)，Wake Forest Baptist Med Ctr, Dept Plast & Reconstruct Surg, One Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM ipestana@wakehealth.edu
RI Pestana, Ivo Alexander/JMR-2324-2023
OI Pestana, Ivo Alexander/0000-0001-6272-4213
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   Wilensky JS, 2005, ANN PLAS SURG, V54, P297, DOI 10.1097/01.sap.0000147173.67172.2a
NR 22
TC 9
Z9 9
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD AUG
PY 2021
VL 165
IS 2
BP 275
EP 281
AR 0194599820986582
DI 10.1177/0194599820986582
EA FEB 2021
PG 7
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA TY5PT
UT WOS:000682551400001
PM 33588623
DA 2026-07-24
ER

PT J
AU Wallin, AM
   Boström, L
   Ulfvarson, J
   Ottosson, C
AF Wallin, Ann-Mari
   Bostrom, Lennart
   Ulfvarson, Johanna
   Ottosson, Carin
TI Negative Pressure Wound Therapy - A Descriptive Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; retrospective descriptive study; wound
   healing; wounds and injuries; comorbidity
ID CLOSURE; VACUUM; ULCERS
AB To address a persistent lack of evidence regarding the clinical outcomes of negative pressure wound therapy (NPWT) and identify which patient groups are most likely to benefit from NPWT, a retrospective, descriptive study was conducted to describe outcomes of this treatment modality when used in clinical practice. Charts from a consecutive series of 87 patients (median age 68 years, range 16 - 92 years) who received NPWT during a period of 24 months were abstracted to a statistical software file. Patient demographics, history, and comorbidity variables as well as treatment outcomes were obtained from the computerized in- and outpatient record system. Treatment outcomes were grouped as successful (goal of care was met) or not successful (goal of care was not met). Successful treatment was noted for a total of 62 patients (71%) with a median treatment time of 17 days. The proportion of patients with a successful outcome was significantly higher in patients with infectious, postoperative, and traumatic wounds than in patients with wounds related to peripheral vascular disease or pressure ulcers (P = 0.001). Treatment complications were observed in 18 patients (21%); five were related to infection. Quality-of-life concerns were noted as a reason for stopping treatment in four patients and equipment problems were recorded for two patients receiving NPWT in the home. This study confirms previous research that NPWT may be an effective and safe treatment method for acute wounds but further studies are needed to evaluate treatment efficacy and effectiveness in patients with peripheral vascular disease or pressure-induced wounds. Results also suggest that research protocols should include patient quality-of-life outcomes.
C1 [Wallin, Ann-Mari; Bostrom, Lennart] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Neurobiol & Soc, S-11883 Stockholm, Sweden.
   [Ottosson, Carin] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Orthoped Surg, S-11883 Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Sodersjukhuset Hospital; Sodersjukhuset Hospital; Karolinska Institutet
RP Wallin, AM (通讯作者)，Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
EM ann-mari.wallin@soder-sjukhuset.se
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NR 13
TC 6
Z9 7
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2011
VL 57
IS 6
BP 22
EP +
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 780GR
UT WOS:000291843000006
PM 21701045
DA 2026-07-24
ER

PT J
AU Moellhoff, N
   Demmer, W
   Pistek, S
   Wachtel, N
   Bodenschatz, K
   Lui, LL
   Alfertshofer, M
   Frank, K
   Giunta, RE
   Ehrl, D
AF Moellhoff, Nicholas
   Demmer, Wolfram
   Pistek, Svenja
   Wachtel, Nikolaus
   Bodenschatz, Karl
   Lui, Lulin
   Alfertshofer, Michael
   Frank, Konstantin
   Giunta, Riccardo E.
   Ehrl, Denis
TI Impact of Negative Pressure Wound Therapy on Perfusion Dynamics in Free
   Latissimus Dorsi Muscle Flaps
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE microsurgery; free flap; free latissimus dorsi muscle-flap;
   microcirculation; O2C; negative pressure wound therapy (NPWT)
ID MICROSURGICAL VASCULAR ANASTOMOSES; NECK RECONSTRUCTION; COMPOSITE
   TISSUES; HEAD; TRANSPLANTATION; COMPLICATIONS; EXPERIENCE; OUTCOMES;
   SITE
AB Background: Free muscle flaps can develop significant postoperative edema and wound exudation, thereby increasing interstitial pressure and potentially compromising microcirculation. While concerns exist regarding negative pressure wound therapy (NPWT) to compress free flaps and hinder monitoring, recent studies have indicated a reduction in edema and an increase in blood flow. Objective: To compare microcirculation in free latissimus dorsi muscle (LDM) flaps dressed with and without NPWT. Methods: This retrospective cohort study analyzed prospectively collected data of patients who received free LDM flap reconstruction. Patients were separated into two groups according to management with or without NPWT. Microcirculation was evaluated continuously for up to 72 h utilizing laser doppler flowmetry and tissue spectrometry. Results: In total, n = 61 patients (26 females, 35 males) with an average age of 56.90 (17.4) years were included. NPWT was applied in 12 patients, while a regular cotton dressing was used in 49 patients. Overall, no significant differences in the number of minor and major complications were observed between groups. Both groups showed an increase in microvascular flow over the investigated time period. The flow showed higher absolute values in the NPWT group, reaching statistical significance at 12 h post-anastomosis, p = 0.038. There was a tendency for lower rHb values in the NPWT group, without reaching statistical significance. Conclusions: The presented study confirms the increase in microvascular flow after NPWT application. Whilst ensuring continuous free flap monitoring utilizing laser doppler flowmetry and spectrometry, the data further support the safety of NPWT application without risking vascular compromise due to external compression.
C1 [Moellhoff, Nicholas; Demmer, Wolfram; Pistek, Svenja; Wachtel, Nikolaus; Lui, Lulin; Alfertshofer, Michael; Frank, Konstantin; Giunta, Riccardo E.; Ehrl, Denis] Univ Hosp Munich LMU, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.
   [Bodenschatz, Karl] Paracelsus Med Univ, Nuremberg Gen Hosp, Dept Pediat Surg & Urol, D-90419 Nurnberg, Germany.
   [Ehrl, Denis] Hosp Nuremberg, Ctr Severe Burn Injuries, Clin Plast Reconstruct & Hand Surg, D-90471 Nurnberg, Germany.
C3 University of Munich
RP Ehrl, D (通讯作者)，Univ Hosp Munich LMU, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.; Ehrl, D (通讯作者)，Hosp Nuremberg, Ctr Severe Burn Injuries, Clin Plast Reconstruct & Hand Surg, D-90471 Nurnberg, Germany.
EM denis.ehrl@klinikum-nuernberg.de
RI ; Wachtel, Nikolaus/LRC-2273-2024; Giunta, Riccardo/JVN-5790-2024;
   Alfertshofer, Michael/ACL-5945-2022
OI Frank, Konstantin/0000-0001-6994-8877; Ehrl, Denis/0000-0001-9394-8412;
   Wachtel, Nikolaus/0000-0003-3746-7838; Alfertshofer,
   Michael/0000-0002-4892-2376
CR Abdel-Galil K, 2009, BRIT J ORAL MAX SURG, V47, P351, DOI 10.1016/j.bjoms.2008.11.013
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NR 34
TC 4
Z9 4
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2024
VL 13
IS 17
AR 5261
DI 10.3390/jcm13175261
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F6P8K
UT WOS:001311026800001
PM 39274475
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hong, J
   Xie, LC
   Fan, LB
   Huang, HY
AF Hong, Jin
   Xie, Licheng
   Fan, Libin
   Huang, Haiyan
TI 被撤回的出版物: The wound adjuncts effect of closed incision negative pressure
   wound therapy on stopping groin surgical site wound infection in
   arterial surgery: A meta-analysis (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE arterial surgery; closed incision negative pressure wound therapy;
   groin; surgical site wound infection
ID VASCULAR-SURGERY; SYSTEMIC BIOAVAILABILITY; PREVENTION; TERBUTALINE;
   TRIAL; REVASCULARIZATION; COMPLICATIONS; INHALATION; MANAGEMENT;
   REDUCTION
AB A meta-analysis study was conducted to assess the influence of the wound adjuncts therapy of closed incision negative pressure wound therapy (ciNPWT) on stopping groin site wound infection (SWSI) in arterial surgery. A comprehensive literature examination till January 2023 was implemented and 2186 linked studies were appraised. The picked studies contained 2133 subjects with groin surgical wounds of arterial surgery in the picked studies' baseline, 1043 of them were using ciNPWT, and 1090 were using standard care. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of the wound adjuncts therapy of ciNPWT on stopping groin SWSI in arterial surgery by the dichotomous and continuous styles and a fixed or random model. The ciNPWT had a significantly lower SWSI (OR, 0.42; 95% CI, 0.33-0.55, P < .001), superficial SWSI (OR, 0.46; 95% CI, 0.33-0.66, P < .001), and deep SWSI (OR, 0.39; 95% CI, 0.25-0.63, P < .001) compared with the standard care in groin surgical wound of arterial surgery. The ciNPWT had a significantly, lower SWSI, superficial SWSI, and deep SWSI compared with the standard care in groin surgical wounds of arterial surgery. Although precautions should be taken when commerce with the consequences because some of the picked studies for this meta-analysis was with low sample sizes.
C1 [Hong, Jin; Xie, Licheng; Fan, Libin; Huang, Haiyan] Shaoxing Univ, Dept Vasc Hernia Surg, Affiliated Hosp, Shaoxing, Zhejiang, Peoples R China.
   [Huang, Haiyan] Shaoxing Univ, Affiliated Hosp, Dept Vasc Hernia Surg, Shaoxing 312000, Zhejiang, Peoples R China.
C3 Shaoxing University; Shaoxing University
RP Huang, HY (通讯作者)，Shaoxing Univ, Affiliated Hosp, Dept Vasc Hernia Surg, Shaoxing 312000, Zhejiang, Peoples R China.
EM hongjin148@163.com
RI xie, licheng/NDT-3507-2025; Huang, Huanghaiyan/IQW-8615-2023
CR Abdelrahim M., J PHARM PHARM
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NR 46
TC 3
Z9 4
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2023
VL 20
IS 7
BP 2726
EP 2734
DI 10.1111/iwj.14146
EA MAR 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA W7PH0
UT WOS:000957931300001
PM 36977282
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Scarpa, C
   de Antoni, E
   Vindigni, V
   Bassetto, F
AF Scarpa, Carlotta
   de Antoni, Eleonora
   Vindigni, Vincenzo
   Bassetto, Franco
TI Efficacy of Negative Pressure Wound Therapy With Instillation and Dwell
   Time for the Treatment of a Complex Chronic Venous Leg Ulcer
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; venous
   leg ulcer; chronic wound; infected ulcer
AB Introduction. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) of topical solutions is a useful method for managing difficult-to-heal wounds, particularly for contaminated chronic ulcers. Most patients with chronic ulcers are affected by several pathologies that systemically impair wound healing; local slough and bacteria further increase the risk of treatment failure. Case Report. A 57-year-old male with obesity, diabetes, and heart disease presented with infected venous leg ulcers of 2 years' duration. The patient came to the authors' attention after unsuccessful treatment with advanced wound care dressings. The patient underwent surgical debridement and application of NPWTi-d with saline solution (settings: -100 mm Hg, 32 mL of instilled volume, 10-minute dwell time, and 2-hour cycle length) for 16 days. This resulted in good granulation tissue formation on the wound bed, so a meshed skin graft was used to cover the wound. In order to improve the skin graft take, the authors dressed it with polyvinyl alcohol foam connected to a traditional NPWT device (settings: -75 mm Hg, continuous pressure) for 1 week. After this period, complete wound healing was achieved, and the wound remained closed and stable upon follow-up. Conclusions. In the authors' opinion, NPWTi-d of topical solutions can be very useful in order to enhance debridement and reduce bacterial load. This kind of treatment allowed the authors to obtain a very good wound bed, and its application was very quick and easy to use, with no adverse events.
C1 [Scarpa, Carlotta; de Antoni, Eleonora; Vindigni, Vincenzo; Bassetto, Franco] Univ Hosp Padova, Inst Plast Surg, Padua, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova
RP Scarpa, C (通讯作者)，Inst Plast Surg, Neurosci, Via Gustinani 2, I-35100 Padua, Italy.
EM carlotta.scarpa@unipd.it
RI /P-9974-2019; Vindigni, Vincenzo/K-5059-2016; Scarpa,
   Carlotta/HJG-7233-2022
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NR 11
TC 1
Z9 1
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 372
EP 374
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500003
PM 33472164
DA 2026-07-24
ER

PT J
AU Kim, S
   Kang, SI
AF Kim, Sohyun
   Kang, Sung Il
TI The effectiveness of negative-pressure wound therapy for wound healing
   after stoma reversal: a randomised control study (SR-PICO study)
SO TRIALS
LA English
DT Article
DE Negative-pressure wound therapy; PICO (TM) system; Purse-string suture;
   Stoma reversal
ID SURGICAL SITE INFECTION; LOOP ILEOSTOMY REVERSAL; PURSESTRING CLOSURE;
   TRIAL; RISK; METAANALYSIS; PREVENTION; PATIENT; REDUCE; SKIN
AB Background Although the wound-healing period for purse-string closure (PSC) after stoma reversal is longer than that required for the primary closure method, the rate of wound infection is reduced. The application of negative-pressure wound therapy (NPWT) can reduce the healing period for many types of wounds. Herein, we describe a planned trial to test the hypothesis that NPWT can reduce the healing period for PSC after stoma reversal. Methods/design Patients undergoing stoma reversal will be recruited and allocated into intervention and control groups, with 1:1 randomisation. Patients in the control group will receive standard postsurgical wound care; patients in the intervention group will receive NPWT using the PICO (TM) system. The target sample size will be 38 patients, as this will provide 80% power at the 5% level of significance to detect a 7-day reduction in the wound-healing period in the intervention group compared to that in the control group. The primary endpoint will be the duration to wound healing, defined as the time to nearly complete epithelisation of the wound, without any discharge or surgical site infection (SSI). Secondary endpoints will be the SSI rate, length of postoperative hospital stay, number of wound dressings and visits to the hospital for wound dressing after discharge, total cost of wound dressings, and patient and observer scar assessment scale scores. Discussion The results of this planned randomised controlled study will clarify the role of NPWT in patients undergoing stoma reversal and strengthen the rationale for choosing a dressing technique.
C1 [Kim, Sohyun; Kang, Sung Il] Yeungnam Univ, Dept Surg, Med Ctr, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University
RP Kang, SI (通讯作者)，Yeungnam Univ, Dept Surg, Med Ctr, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM sungiry@naver.com
OI Kang, Sung Il/0000-0002-4751-5779
FU 2019 Yeungnam University Research Grant programme [2019A580017]
FX This work was supported with non-profit grants from the 2019 Yeungnam
   University Research Grant programme (2019A580017). The funder had no
   role in the study design. The funder also will have no role in data
   collection, analysis, interpretation, or presentation of the results.
   The authors declare that there was neither any support from, nor a
   relationship with, the company manufacturing the dressing material
   device in this study.
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NR 18
TC 14
Z9 16
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 6
PY 2020
VL 21
IS 1
AR 24
DI 10.1186/s13063-019-3925-z
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KN2BY
UT WOS:000514647500006
PM 31907033
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, GQ
   Li, ZR
   Wang, S
   Li, TT
   Zhang, LH
   Zhang, LC
   Tang, PF
AF Wang Guoqi
   Li Zhirui
   Wang Song
   Li Tongtong
   Zhang Lihai
   Zhang Licheng
   Tang Peifu
TI Negative pressure wound therapy reduces the motility of Pseudomonas
   aeruginosa and enhances wound healing in a rabbit ear biofilm
   infection model
SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR
   MICROBIOLOGY
LA English
DT Article
DE Negative pressure wound therapy; Infection; Virulence factor; Biofilm;
   Wound
ID BACTERIAL BIOFILMS; IN-VIVO; STAPHYLOCOCCUS-AUREUS; POTENTIAL ROLE;
   SKIN; ELASTASE; GROWTH; MECHANISMS; STRATEGIES; ANTIBODIES
AB Pseudomonas aeruginosa motility, virulence factors and biofilms are known to be detrimental to wound healing. The efficacy of negative pressure wound therapy (NPWT) against P. aeruginosa has been little studied, either in vitro or in vivo. The present study evaluated the effect of negative pressure (NP) on P. aeruginosa motility in vitro, and the effect of NPWT on virulence factors and biofilms in vivo. P. aeruginosa motility was quantified under different levels of NP (atmospheric pressure, - 75, - 125, - 200 mmHg) using an in vitro model. Swimming, swarming and twitching motility were significantly inhibited by NP (- 125 and - 200 mmHg) compared with atmospheric pressure (p = 0.05). Virulence factors and biofilm components were quantified in NPWT and gauze treated groups using a rabbit ear biofilm model. Biofilm structure was studied with fluorescence microscopy and scanning electron microscopy. Additionally, viable bacterial counts and histological wound healing parameters were measured. Compared with the control, NPWT treatment resulted in a significant reduction in expression of all virulence factors assayed including exotoxin A, rhamnolipid and elastase (p = 0.01). A significant reduction of biofilm components (eDNA) (p = 0.01) was also observed in the NPWT group. The reduction of biofilm matrix was verified by fluorescence- and scanning electron-microscopy. NPWT lead to better histologic parameters (p = 0.01) and decreased bacterial counts (p = 0.05) compared with the control. NPWT treatment was demonstrated to be an effective strategy to reduce virulence factors and biofilm components, which may explain the increased wound healing observed.
C1 [Wang Guoqi; Li Zhirui; Zhang Lihai; Zhang Licheng; Tang Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Wang Song] Nankai Univ, Med Coll, Tianjin 300071, Peoples R China.
   [Li Tongtong] Tianjin Hosp, Dept Orthoped, 406 Jiefangnan Rd, Tianjin 300211, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Nankai University;
   Tianjin University
RP Zhang, LC; Tang, PF (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM guoqi71@126.com; lzr860514@163.com; mrwangsng@163.com; li_cucu@163.com;
   zhanglihai301@gmail.com; zhanglcheng218@126.com; pftang301@163.com
RI Li, Zhirui/OJT-0490-2025
FU National Natural Science Foundation of China [81472112]
FX This study was supported by National Natural Science Foundation of China
   (No. 81472112).
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NR 53
TC 20
Z9 21
U1 0
U2 36
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0003-6072
EI 1572-9699
J9 ANTON LEEUW INT J G
JI Antonie Van Leeuwenhoek
PD SEP
PY 2018
VL 111
IS 9
BP 1557
EP 1570
DI 10.1007/s10482-018-1045-5
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA GQ5MR
UT WOS:000441729300006
PM 29468490
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Arundel, C
   Buckley, H
   Clarke, E
   Cullum, N
   Dixon, S
   Dumville, J
   Fairhurst, C
   Firth, A
   Henderson, E
   Lamb, K
   McGinnis, E
   Oswald, A
   Goncalves, PS
   Soares, M
   Stubbs, N
   Torgerson, D
   Chetter, I
AF Arundel, Catherine
   Buckley, Hannah
   Clarke, Emma
   Cullum, Nicky
   Dixon, Stephen
   Dumville, Jo
   Fairhurst, Caroline
   Firth, Anna
   Henderson, Eileen
   Lamb, Karen
   McGinnis, Elizabeth
   Oswald, Angela
   Goncalves, Pedro Saramago
   Soares, Marta
   Stubbs, Nikki
   Torgerson, David
   Chetter, Ian
TI Negative pressure wound therapy versus usual care for Surgical Wounds
   Healing by Secondary Intention (SWHSI trial): study protocol for a
   randomised controlled pilot trial
SO TRIALS
LA English
DT Article
DE Surgical wounds; Negative pressure wound therapy; Secondary intention;
   Healing; Randomised controlled trial
AB Background: Most incisions following surgery heal by primary intention, with the edges of the wound apposed with sutures or clips. However, some wounds may break open or be left to heal from the bottom up (i.e. healing by secondary intention). Surgical Wounds Healing by Secondary Intention (SWHSI) are often more complex to manage, and require additional treatments during the course of healing. There is significant uncertainty regarding the best treatment for these complex wounds, with limited robust evidence regarding the clinical and cost-effectiveness of different dressings and treatments; one such treatment is Negative Pressure Wound Therapy (NPWT) which is frequently used in the management of SWHSI. Previous randomised controlled trials (RCTs) of NPWT have failed to recruit to time and target, thus we aimed to conduct a pilot RCT to assess the feasibility of conducting a future, full-scale RCT.
   Methods: This pilot RCT will test the methods and feasibility of recruiting, randomising, and retaining participants into a larger trial of NPWT verses usual care for patients with SWHSI. Participants will be randomised to receive either NPWT or usual care (no NPWT) and will be followed up for 3 months.
   Discussion: This study will provide a full assessment of methods for, and feasibility of, recruiting, randomising, and retaining patients with SWHSI in a trial of NPWT versus usual care. On the basis of this pilot trial, a full trial may be proposed in the future which will provide additional, robust evidence on the clinical and cost-effectiveness of NPWT in the management of SWHSI.
C1 [Arundel, Catherine; Buckley, Hannah; Fairhurst, Caroline; Torgerson, David] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Clarke, Emma; Firth, Anna; Henderson, Eileen; Oswald, Angela; Chetter, Ian] Hull & East Yorkshire Hosp NHS Trust, Kingston Upon Hull, N Humberside, England.
   [Cullum, Nicky; Dumville, Jo] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Dixon, Stephen] Patient & Publ Involvement Grp Representat, Kingston Upon Hull, N Humberside, England.
   [Lamb, Karen; Stubbs, Nikki] Leeds Community Healthcare NHS Trust, Leeds, W Yorkshire, England.
   [McGinnis, Elizabeth] Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England.
   [Goncalves, Pedro Saramago; Soares, Marta] Univ York, Ctr Hlth Econ, York, N Yorkshire, England.
   [Chetter, Ian] Hull York Med Sch, York, N Yorkshire, England.
C3 University of York - UK; University of Manchester; University of Leeds;
   University of York - UK; University of York - UK; University of Hull
RP Arundel, C (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI ; Torgerson, David/L-4566-2019; Dumville, Jo/O-7867-2014; Cullum,
   Nicky/F-2438-2011; Soares, Marta Ferreira Oliveira/HJH-3434-2023;
   McGinnis, Elizabeth/PNF-2864-2026; Buckley, Hannah/QAX-3702-2026
OI chetter, ian/0000-0002-2566-6859; McGinnis,
   Elizabeth/0000-0002-2848-9149; Torgerson, David/0000-0002-1667-4275;
   Dumville, Jo/0000-0002-6546-3685; Cullum, Nicky/0000-0003-2631-123X;
   Artrong-Lamb, Karen/0000-0002-4172-4289; Soares, Marta Ferreira
   Oliveira/0000-0003-1579-8513; Arundel, Catherine/0000-0003-0512-4339; 
FU NIHR Programme Grants for Applied Research Programme [RP-PG-0609-10171];
   National Institute for Health Research [RP-PG-0609-10171,
   NF-SI-0512-10028] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This project was funded by the NIHR Programme Grants for Applied
   Research Programme (project number RP-PG-0609-10171). The views and
   opinions expressed by authors in this publication are those of the
   authors and do not necessarily reflect those of the NHS, the NIHR, MRC,
   CCF, NETSCC, the Programme Grants for Applied Research Programme or the
   Department of Health.
CR Ashby RL, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-119
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NR 10
TC 12
Z9 16
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD NOV 8
PY 2016
VL 17
AR 535
DI 10.1186/s13063-016-1661-1
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EC5BE
UT WOS:000388147300001
PM 27821142
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tarzia, V
   Carrozzini, M
   Bortolussi, G
   Buratto, E
   Bejko, J
   Comisso, M
   Mescola, V
   Penzo, V
   Guarino, M
   De Franceschi, M
   Pagnin, C
   Castoro, M
   Guglielmi, C
   Testolin, L
   Bottio, T
   Gerosa, G
AF Tarzia, Vincenzo
   Carrozzini, Massimiliano
   Bortolussi, Giacomo
   Buratto, Edward
   Bejko, Jonida
   Comisso, Marina
   Mescola, Valentina
   Penzo, Valentina
   Guarino, Mauro
   De Franceschi, Marco
   Pagnin, Chiara
   Castoro, Massimo
   Guglielmi, Cosimo
   Testolin, Luca
   Bottio, Tomaso
   Gerosa, Gino
TI Impact of vacuum-assisted closure therapy on outcomes of sternal wound
   dehiscenceaEuro
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 27th Annual Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY OCT 05-09, 2013
CL Vienna, AUSTRIA
SP European Assoc Cardio Thorac Surg
DE Vacuum-assisted closure therapy; Sternal wound dehiscence;
   Mediastinitis; Sternal wound complication; Surgical site infection; Cost
   analysis
ID POSTSTERNOTOMY MEDIASTINITIS; COMPLICATIONS; INFECTION; DEFORMATIONS;
   STERNOTOMY
AB OBJECTIVES: Sternal wound dehiscence (SWD) after cardiac surgery is a rare but serious condition associated with considerable costs and morbidity. We sought to evaluate the results of the introduction of vacuum-assisted closure (VAC) therapy in the management of sternal wound dehiscence, compared with those of previous conventional treatments.
   METHODS: We retrospectively collected 7148 patients who underwent cardiac surgery at our institution between January 2002 and June 2012. A total of 152 (2.1%) patients had a sternal wound dehiscence: 107 were treated with conventional treatments (Group A) and 45 were managed with VAC therapy (Group B). Patients were stratified according to preoperative risk factors and type of sternal wound dehiscence (superficial or deep; infected or not) and compared by means of a propensity-matched analysis. A cost analysis was also performed.
   RESULTS: Forty-five patients of each group matched for all preoperative risk factors and type of sternal wound dehiscence. SWD-related mortality rate was significantly lower in Group B (11 vs 0%; P = 0.05). Incidence of mediastinitis (P < 0.0001), sepsis (P = 0.04), delayed SWD infection (P = 0.05), other complication (P = 0.05), surgical sternal revision (P = 0.04) and surgical superficial revision (P < 0.0001) were all significantly lower in Group B. Mean patient cost was 31 106a,not sign in Group A and 24 383a,not sign in Group B, thus achieving a mean saving of 6723a,not sign per patient.
   CONCLUSIONS: In our experience, the use of VAC therapy for the management of SWD was considerably effective in decreasing mortality (SWD related), incidence of complications and need for surgical procedures; thus, leading to a significant reduction of costs.
C1 [Tarzia, Vincenzo; Carrozzini, Massimiliano; Bortolussi, Giacomo; Buratto, Edward; Bejko, Jonida; Comisso, Marina; Mescola, Valentina; Penzo, Valentina; Guarino, Mauro; De Franceschi, Marco; Pagnin, Chiara; Guglielmi, Cosimo; Testolin, Luca; Bottio, Tomaso; Gerosa, Gino] Univ Padua, Cardiac Surg Unit, Dept Cardiac Thorac & Vasc Sci, I-35128 Padua, Italy.
   [Castoro, Massimo] Padova Univ Hosp, Hlth Technol Assessment Unit, Padua, Italy.
C3 University of Padua; University of Padua; Azienda Ospedaliera -
   Universita di Padova
RP Tarzia, V (通讯作者)，Univ Padua, Policlin Univ, Cardiac Surg Unit, Dept Cardiac Thorac & Vasc Sci,Ctr V Gallucci, Via Giustiniani 2, I-35128 Padua, Italy.
EM v.tarzia@gmail.com
RI Tarzia, Vincenzo/AAC-2097-2019; Bortolussi, Giacomo/AAM-3278-2020;
   Buratto, Edward/AAW-9469-2020; Carrozzini, Massimiliano/M-7138-2018;
   Gerosa, Gino/M-8106-2014; BOTTIO, TOMASO/AAQ-9040-2020
OI Tarzia, Vincenzo/0000-0003-2360-2031; Bortolussi,
   Giacomo/0000-0003-3640-1597; Buratto, Edward/0000-0002-8330-3917;
   Carrozzini, Massimiliano/0000-0001-5506-0201; Gerosa,
   Gino/0000-0002-6261-699X; BOTTIO, TOMASO/0000-0001-7299-2983
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bejko J, 2012, ANN THORAC SURG, V94, P1848, DOI 10.1016/j.athoracsur.2012.08.032
   Daigle P, 2013, WOUND REPAIR REGEN, V21, P498, DOI 10.1111/wrr.12052
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   Fuchs U, 2005, ANN THORAC SURG, V79, P526, DOI 10.1016/j.athoracsur.2004.08.032
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   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   Losanoff JE, 2002, EUR J CARDIO-THORAC, V21, P831, DOI 10.1016/S1010-7940(02)00124-0
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Vos RJ, 2012, INTERACT CARDIOV TH, V14, P17, DOI 10.1093/icvts/ivr049
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 16
TC 32
Z9 39
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2014
VL 19
IS 1
BP 70
EP 74
DI 10.1093/icvts/ivu101
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AM2HB
UT WOS:000339669900019
PM 24722512
OA Bronze
DA 2026-07-24
ER

PT J
AU Kelm, J
   Schmitt, E
   Anagnostakos, K
AF Kelm, Jens
   Schmitt, Eduard
   Anagnostakos, Konstantinos
TI Vacuum-assisted closure in the treatment of early hip joint infections
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE vacuum-assisted closure; VAC-therapy; early infection; hip joint
ID THERAPY
AB The aim of the present study was to evaluate the efficacy of the vacuum-assisted closure (V.A.C.) system in the treatment of early hip joint infections. 28 patients (11 m/17 f; mean age 71 y. [43-84]) with early hip joint infections have been treated by means of the V.A.C.-therapy. At least one surgical revision [1-7] has been unsuccessfully performed for infection treatment prior to V.A.C.-application. Pathogen organisms could have been isolated in 22/28 wounds. During revision, cup inlay and prosthesis head have been exchanged and 1-3 polyvinylalcohol sponges inserted into the wound cavity/periprosthetically at an initial continuous pressure of 200 mm Hg. Postoperatively, a systemic antibiosis was given according to antibiogram. 48-72 h after surgery an alteration from haemorrhagic to serous fluid was observed in the V.A.C.-canister. Afterwards, the pressure was decreased to 150 mm Hg and remained at this level till sponge removal. After a mean period of 9 [3-16] days the inflammation parameters have been retrogressive and the sponges were removed. An infection eradication could be achieved in 26/28 cases. In the two remaining cases the infected prosthesis had to be explanted and a gentamicin-vancomycin-loaded spacer has been implanted, respectively. At a total mean follow-up of 36 [12-87] months no reinfection or infection persistence was observed. The V.A.C.-system can be a valuable contribution in the treatment of early joint infections when properly used. Indications should be early infections with well-maintained soft-tissues for retention of the negative atmospheric pressure.
C1 [Kelm, Jens; Schmitt, Eduard; Anagnostakos, Konstantinos] Univ Saarland, Dept Orthopaed Surg, Univ Hosp, D-6650 Homburg, Germany.
   [Kelm, Jens] Chirurg Orthopad Zentrum Illingen Saar, Saar, Germany.
C3 Universitatsklinikum des Saarlandes; Saarland University
RP Anagnostakos, K (通讯作者)，Univ Saarlandes Kliniken, Klin Orthopadie & Orthopad Chirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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   Banwell P E, 1999, J Wound Care, V8, P79
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NR 17
TC 39
Z9 47
U1 0
U2 7
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2009
VL 6
IS 5
BP 241
EP 246
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 541HE
UT WOS:000273405100003
PM 19834589
DA 2026-07-24
ER

PT J
AU Martins, MAB
   Amador, WFO
   Oliveira, REND
   Duda, JR
   Formiga, FB
AF Martins, Marcelo Albuquerque Barbosa
   Amador, Wellgner Fernandes Oliveira
   da Nobrega Oliveira, Rachid Eduardo Noleto
   Duda, Joao Ricardo
   Formiga, Fernanda Bellotti
TI Negative pressure wound therapy in primary closure surgeries for
   pilonidal disease: a meta-analysis
SO UPDATES IN SURGERY
LA English
DT Review; Early Access
DE Negative pressure wound therapy; Pilonidal disease; Surgical wound
ID QUALITY-OF-LIFE; SINUS DISEASE; CARE; MANAGEMENT; MECHANISM
AB Primary closure with negative pressure wound therapy (NPWT) has been investigated in patients with sacrococcygeal pilonidal sinus to enhance healing and reduce recurrence. To address existing controversies, we conducted a systematic review and meta-analysis comparing primary closure with NPWT versus non-NPWT (control) for treatment of pilonidal disease. PubMed, Embase, and Cochrane Library databases were searched from inception to December 2024 to identify studies comparing NPWT versus control in primary closure surgeries in pilonidal sinus. Statistical analyses were performed using R Software with a random-effects model. Six studies with a total of 479 patients were included, of whom 164 (34.2%) underwent NPWT. NPWT had an association with lower pain score 24 h postoperative (MD - 0.65 points; 95% CI - 0.81 to - 0.50), shorter return time to activities (MD - 2.57 days; 95% CI - 3.74 to - 1.4). However, there was no difference between groups in the time of wound closure (MD - 18.94; 95% CI - 41.68 to 3.80), rate of wound dehiscence (RR 1.03; 95% CI 0.50 to 2.14), hospital length of stay (MD - 3.05; 95% CI - 15.77 to 9.67), infection rates (RR 0.38; 95% CI 0.05 to 2.84), recurrence rates (RR 0.54; 95% CI 0.07 to 4.48), and pain 6 h post-operative, which showed a borderline trend favoring NPWT but did not reach statistical significance (MD - 1.19; 95% CI - 2.38 to 0.01). NPWT appears to shorten time to resume normal activities and pain 24 h postoperatively. Despite these promising results, more randomized clinical trials are needed for greater analysis.
C1 [Martins, Marcelo Albuquerque Barbosa] Univ Fed Ouro Preto, Ouro Preto, MG, Brazil.
   [Amador, Wellgner Fernandes Oliveira] Univ Fed Campina Grande, Cajazeiras, PB, Brazil.
   [da Nobrega Oliveira, Rachid Eduardo Noleto] Barretos Canc Hosp, Barretos, SP, Brazil.
   [Duda, Joao Ricardo] Pontificia Univ Catolica Parana, Curitiba, PR, Brazil.
   [Formiga, Fernanda Bellotti] Santa Casa Sao Paulo, Colorectal Surg Unit, Sao Paulo, SP, Brazil.
   [Formiga, Fernanda Bellotti] Hosp Heliopolis, Colorectal Surg Unit, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Campina
   Grande; Hospital de Cancer de Barretos; Pontificia Universidade Catolica
   do Parana
RP Amador, WFO (通讯作者)，Univ Fed Campina Grande, Cajazeiras, PB, Brazil.
EM marceloalbuquerque23.1.2008@gmail.com; wellgnerfernandes@gmail.com;
   toraxbarretos@gmail.com; joaorduda@gmail.com;
   drafernandaformiga@gmail.com
RI Duda, Joao/LLM-4814-2024; Noleto da Nobrega Oliveira, Rachid
   Eduardo/NOE-9733-2025; FORMIGA, Fernanda/MCJ-6517-2025
OI Fernandes Oliveira Amador, Wellgner/0009-0002-3186-2589; 
CR Amorim M, 2023, SURGERY, V174, P480, DOI 10.1016/j.surg.2023.05.035
   Åström M, 2023, QUAL LIFE RES, V32, P2719, DOI 10.1007/s11136-023-03411-3
   Banasiewicz Tomasz, 2013, Pol Przegl Chir, V85, P371, DOI 10.2478/pjs-2013-0056
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   Liu X, 2023, INT WOUND J, V20, P3474, DOI 10.1111/iwj.14218
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   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.n71
   Singh S, 2024, SURG CLIN N AM, V104, P503, DOI 10.1016/j.suc.2023.11.003
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   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
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   Ulusoy C, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000031934
   Vartanian E, 2018, ANN PLAS SURG, V81, pE12, DOI 10.1097/SAP.0000000000001585
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Wohlin Claes., 2014, 18 INT C EVALUATION, P38, DOI [10.1145/2601248.2601268, DOI 10.1145/2601248.2601268]
   Wu PL, 2023, INT J SURG, V109, P2388, DOI 10.1097/JS9.0000000000000447
NR 34
TC 3
Z9 3
U1 1
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD 2026 MAR 25
PY 2026
DI 10.1007/s13304-026-02536-7
EA MAR 2026
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FN5RF
UT WOS:001722995000001
PM 41880146
DA 2026-07-24
ER

PT J
AU Choi, D
   Cho, WT
   Song, HK
   Kwon, J
   Kang, BH
   Jung, H
   Kim, MJ
   Jung, K
AF Choi, Donghwan
   Cho, Won Tae
   Song, Hyung Keun
   Kwon, Junsik
   Kang, Byung Hee
   Jung, Hohyung
   Kim, Min Ji
   Jung, Kyoungwon
TI Conventional versus Instillation Negative-Pressure Wound Therapy for
   Severe Soft Tissue Injury in Open Pelvic Fractures: A Retrospective
   Review
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Negative-pressure wound therapy; instillation; open fractures; pelvis;
   soft tissue infection; wound healing
ID ASSISTED CLOSURE VAC(TM); CARE; MANAGEMENT; MORTALITY; SEPSIS
AB Purpose: We investigated the clinical features, current negative-pressure wound therapy (NPWT) management strategies, and outcomes of pelvic-perineal soft tissue infection after open pelvic fractures. Materials and Methods: We analyzed the data of patients admitted to our trauma center with pelvic-perineal soft tissue after open pelvic fractures over a 7-year period. We investigated the injury severity score (ISS), medical costs, number of NPWTs, time required to reach definite wound coverage, complications, fracture classifications, transfusion requirements, interventions, length of stay (LOS) in hospital and intensive care unit (ICU), and prognosis. Results: Twenty patients with open pelvic fractures were treated with NPWT, and one patient who underwent NPWT died of pelvic sepsis during ICU treatment. The median LOS in hospital and medical costs were 98 [56-164] days and 106400 [65600-171100] USD, respectively. Patients treated with instillation NPWT (iNPWT, n=10) had a shorter NPWT duration (24 [13-39] vs. 46 [42-91] days, p=0.023), time to definite wound coverage (30 [21-43] vs. 49 [42-93] days, p=0.026), and hospital LOS (56 [43-72] vs. 158 [101-192] days, p=0.001), as well as lower medical costs (67800 [42500-102500] vs. 144200 [110400-236000] USD, p=0.009) compared to those treated with conventional NPWT. Conclusion: NPWT is a feasible method for treating pelvic soft tissue infections in patients with open pelvic fractures. iNPWT can reduce the duration of NPWT, hospital LOS, and medical costs.
C1 [Choi, Donghwan; Kwon, Junsik; Kang, Byung Hee; Jung, Hohyung; Jung, Kyoungwon] Ajou Univ, Sch Med, Dept Surg, Div Trauma Surg, 164 Worldcup Ro, Suwon 16499, South Korea.
   [Cho, Won Tae; Song, Hyung Keun] Ajou Univ, Sch Med, Dept Orthoped Surg, Suwon, South Korea.
   [Kim, Min Ji] Ajou Univ, Dept Plast Surg, Sch Med, Dept Surg, Suwon, South Korea.
C3 Ajou University; Ajou University; Ajou University
RP Jung, K (通讯作者)，Ajou Univ, Sch Med, Dept Surg, Div Trauma Surg, 164 Worldcup Ro, Suwon 16499, South Korea.
EM jake98@daum.net
RI Kwon, Junsik/AAE-3143-2022; Choi, Donghwan/JXN-6996-2024
OI Kwon, Junsik/0000-0003-3164-4995; Choi, Donghwan/0000-0001-7596-4371;
   Cho, Won-Tae/0000-0002-9764-3912; Kim, Min Ji/0000-0002-0723-4382; Jung,
   Hohyung/0000-0002-5536-5483; Kang, Byung Hee/0000-0003-3204-3251; Song,
   Hyung Keun/0000-0001-5486-2560
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
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   Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
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   Zhang N, 2020, BMC SURG, V20, DOI 10.1186/s12893-020-00916-3
NR 30
TC 0
Z9 0
U1 0
U2 0
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD FEB
PY 2025
VL 66
IS 2
BP 94
EP 102
DI 10.3349/ymj.2023.0473
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U1G1U
UT WOS:001409352900004
PM 39894042
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Doval, AF
   Chegireddy, V
   Beal, L
   Arroyo-Alonso, C
   Zavlin, D
   Spiegel, AJ
   Ellsworth, WA
AF Doval, Andres F.
   Chegireddy, Vishwanath
   Beal, Lauren
   Arroyo-Alonso, Christian
   Zavlin, Dmitry
   Spiegel, Aldona J.
   Ellsworth, Warren A.
TI Efficacy of Closed Incision Negative Pressure Wound Therapy on Abdominal
   Donor Site After Free Flap Breast Reconstruction
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE closed incision negative pressure wound therapy; DIEP flap; donor site;
   surgical
ID RISK-FACTORS; DIEP FLAPS; COMPLICATIONS; MASTECTOMY; PREVENTION;
   MANAGEMENT; WOMEN
AB Introduction. Negative pressure wound therapy (NPWT) has been used to treat acute and chronic wounds in a variety of scenarios. Specifically, in autologous breast reconstruction, studies investigating the use of closed incision NPWT (ciNPWT) in breast surgery are lacking. Objective. The aim of this study was to analyze the use of ciNPWT at the abdominal donor site following deep inferior epigastric perforator (DIEP) flap breast reconstruction. Materials and Methods. A retrospective cohort study was conducted over a 15-month period including patients who underwent abdominally based microsurgical breast reconstruction. Patients were divided into 2 groups: (1) a control group that underwent standard abdominal donor site closure and (2) an experimental group that underwent standard abdominal donor site closure plus ciNPWT. Groups were compared in terms of demographic characteristics, perioperative variables, and abdominal donor site complications. Results. A total of 42 patients were identified. Of these, 18 were included in the control group and 24 in the ciNPWT group. No cases of seroma, abdominal bulge, or abdominal hernia were reported. Wound dehiscence developed in 2 patients (11.1%) in the control group and in 3 patients (12.5%) in the experimental group (P = 1.000). One patient (5.6%) in the control group had an infection of the donor site compared with none in the ciNPWT group (P = .429). Interestingly, 3 patients developed hyperpigmentation where the ciNPWT plastic drape was placed. Conclusions. The use of ciNPWT on the abdominal donor site following DIEP flap breast reconstruction did not lower the incidence of wound dehiscence and wound infection. Different approaches are needed to decrease the incidence of donor site complications in abdominally based postmastectomy breast reconstruction.
C1 [Doval, Andres F.; Chegireddy, Vishwanath; Beal, Lauren; Arroyo-Alonso, Christian; Zavlin, Dmitry; Spiegel, Aldona J.; Ellsworth, Warren A.] Houston Methodist Hosp, Inst Reconstruct Surg, Weill Cornell Med, Houston, TX USA.
C3 Houston Methodist
RP Ellsworth, WA (通讯作者)，Methodist West Houston Hosp, Inst Reconstruct Surg, 18400 Katy Freeway,Suite 500, Houston, TX 77094 USA.
EM WAEllsworth@houstonmethodist.org
OI spiegel, Aldona/0000-0002-8040-320X
CR Bi HD, 2018, J RECONSTR MICROSURG, V34, P200, DOI 10.1055/s-0037-1608621
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NR 29
TC 16
Z9 17
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2021
VL 33
IS 4
BP 81
EP 85
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SD0QW
UT WOS:000651068500004
PM 33872200
DA 2026-07-24
ER

PT J
AU Acosta, J
   Galarza, L
   Marsh, M
   Martinez, RR
   Eells, M
   Collinsworth, AW
AF Acosta, Julie
   Galarza, Lydia
   Marsh, Margaret
   Martinez, Ricardo R.
   Eells, Mark
   Collinsworth, Ashley W.
TI Effectiveness of Negative Pressure Wound Therapy With Instillation and
   Dwell in Removing Nonviable Tissue, Promoting Granulation Tissue, and
   Reducing Surgical Debridements: A Systematic Literature Review
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
DE debridement; negative pressure wound therapy with instillation; wound
   cleansing; wound treatment
ID OPEN-CELL FOAM; EARLY-STAGE MANAGEMENT; HOLES; TIME
AB Surgical debridement is a common treatment for complex wounds but can present risks for patients. Negative pressure wound therapy with instillation and dwell (NPWTi-d) using reticulated open cell foam dressings with 1 cm holes (ROCF-CC) provides hydromechanical wound cleaning and preparation and can be applied outside the operating room at the bedside. This systematic literature review examined the effectiveness of NPWTi-d with ROCF-CC in removing nonviable tissue and infectious material, promoting granulation tissue, and reducing surgical debridements. A systematic search was conducted utilising PubMed, Embase, and ClinicalTrials.gov to identify studies conducted from 1 January 2015-31 August 2022. Study outcomes related to nonviable tissue, granulation tissue, and debridement were summarised and analysed using descriptive statistics. Twenty-one studies including 178 patients who received NPWTi-d with ROCF-CC were included. Evidence of reduction in necrotic and infected tissue following treatment was observed in 97.9% of wounds across 17 studies. Formation of granulation tissue after NPWTi-d with ROCF-CC was reported in 99.2% of wounds across 14 studies. Over 63% of patients avoided surgical debridements in 8 studies, and a statistically significant decrease in surgical debridements was noted in 2 comparative studies. This systematic review provides real-world evidence demonstrating the effectiveness of NPWTi-d with ROCF-CC in the hydromechanical removal of infectious materials, non-viable tissue, and wound debris; reduction of surgical debridements; and promotion of granulation tissue. Thus, NPWTi-d with ROCF-CC may potentially reduce or eliminate the need for surgical debridement by removing non-viable tissue through hydromechanical action.
C1 [Acosta, Julie; Galarza, Lydia; Marsh, Margaret; Martinez, Ricardo R.; Eells, Mark; Collinsworth, Ashley W.] Solventum, Med Surg, Maplewood, MN 55144 USA.
RP Collinsworth, AW (通讯作者)，Solventum, Med Surg, Maplewood, MN 55144 USA.
EM acollinsworth@solventum.com
OI Collinsworth, Ashley/0000-0001-8039-7586
CR Aburn R., 2021, Wounds UK, V17, P51
   Blalock L, 2019, WOUNDS, V31, P55
   Chowdhry S. A., 2020, S ADV WOUND CAR SAWC
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   Delapena Samantha, 2020, Wounds, V32, pE96
   Dingess J., 2019, Clinical Case Series of the Efficacy of Using NPWT With Instillation and Reticulated Open Cell Foam for Trauma Wounds
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NR 32
TC 3
Z9 3
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL
PY 2025
VL 33
IS 4
AR e70059
DI 10.1111/wrr.70059
PG 15
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 6SI3P
UT WOS:001560849400002
PM 40583835
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Tsuji, M
   Kakuda, N
   Bujo, C
   Saito, A
   Ishida, J
   Amiya, E
   Hatano, M
   Shimada, A
   Imai, H
   Kimura, M
   Ando, M
   Kinoshita, O
   Yamauchi, H
   Komuro, I
   Ono, M
AF Tsuji, Masaki
   Kakuda, Nobutaka
   Bujo, Chie
   Saito, Akihito
   Ishida, Junichi
   Amiya, Eisuke
   Hatano, Masaru
   Shimada, Asako
   Imai, Hiroko
   Kimura, Mitsutoshi
   Ando, Masahiko
   Kinoshita, Osamu
   Yamauchi, Haruo
   Komuro, Issei
   Ono, Minoru
TI Prophylactic negative pressure wound therapy is not effective for
   preventing driveline infection following left ventricular assist device
   implantation
SO ARTIFICIAL ORGANS
LA English
DT Article
DE driveline infection; left ventricular assist device; negative pressure
   wound therapy
ID SITE INFECTION; MANAGEMENT; SUPPORT; COMPLICATIONS; LAPAROTOMY; CLOSURE;
   TRIAL
AB Background Driveline infection (DLI) following left ventricular assist device (LVAD) implantation remains an unresolved problem. Negative pressure wound therapy (NPWT) promotes wound healing by applying negative pressure on the surface of the wound. Recently, the prophylactic application of NPWT to closed surgical incisions has decreased surgical site infections in various postsurgical settings. Therefore, we evaluated the efficacy and safety of prophylactic NPWT for preventing DLI in patients with LVAD implantation. Methods Prophylactic NPWT was provided to 50 patients who received continuous-flow LVADs as bridge-to-transplant therapy at our institution between May 2018 and October 2020 (NPWT group). The negative pressure dressing was applied immediately after surgery and retained on the driveline exit site for 7 days with a continuous application of -125 mm Hg negative pressure. The primary outcome was DLI within 1 year of LVAD implantation. We compared the rate of DLI incidence in the NPWT group with that in the historical control cohort (50 patients) treated with the standard dressing (SD) who received LVAD implantation between July 2015 and April 2018 (SD group). Results No severe complications were associated with the NPWT. During the follow-up period, DLI was diagnosed in 16 participants (32%) in the NPWT group and 21 participants (42%) in the SD group. The rates of DLI incidence and freedom from DLI did not differ between groups (p = 0.30 and p = 0.63). Conclusions Prophylactic NPWT at the driveline exit site was safe following LVAD implantation. However, it did not significantly reduce the risk of DLI.
C1 [Tsuji, Masaki; Kakuda, Nobutaka; Bujo, Chie; Saito, Akihito; Ishida, Junichi; Amiya, Eisuke; Hatano, Masaru; Komuro, Issei] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan.
   [Bujo, Chie; Amiya, Eisuke] Univ Tokyo, Dept Therapeut Strategy Heart Failure, Tokyo, Japan.
   [Hatano, Masaru] Univ Tokyo, Dept Adv Med Ctr Heart Failure, Tokyo, Japan.
   [Shimada, Asako; Imai, Hiroko] Univ Tokyo, Grad Sch Med, Dept Organ Transplantat, Tokyo, Japan.
   [Kimura, Mitsutoshi; Ando, Masahiko; Kinoshita, Osamu; Yamauchi, Haruo; Ono, Minoru] Univ Tokyo, Grad Sch Med, Dept Cardiac Surg, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo;
   University of Tokyo; University of Tokyo
RP Tsuji, M (通讯作者)，Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan.
EM mtsuji-cib@umin.ac.jp
RI Amiya, Eisuke/O-4981-2019; Komuro, Issei/JXL-2876-2024
OI Kimura, Mitsutoshi/0009-0007-9071-4400; 
FU Grants-in-Aid for Scientific Research [21K08047] Funding Source: KAKEN
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NR 35
TC 4
Z9 4
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD MAR
PY 2023
VL 47
IS 3
BP 566
EP 573
DI 10.1111/aor.14440
EA NOV 2022
PG 8
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA Q5SQ5
UT WOS:000881945400001
PM 36300650
DA 2026-07-24
ER

PT J
AU Almansa-Saura, S
   Lopez-Lopez, V
   Eshmuminov, D
   Schneider, M
   Castellanos-Escrig, G
   Rodriguez-Valiente, M
   Crespo, MJ
   von der Groeben, M
   Lehmann, K
   Robles-Campos, R
AF Almansa-Saura, Sonia
   Lopez-Lopez, Victor
   Eshmuminov, Dilmurodjon
   Schneider, Marcel
   Castellanos-Escrig, Gregorio
   Rodriguez-Valiente, Monica
   Crespo, Maria Jesus
   von der Groeben, Markus
   Lehmann, Kuno
   Robles-Campos, Ricardo
TI Prophylactic Use of Negative Pressure Therapy in General Abdominal
   Surgery: A Systematic Review and Meta-Analysis
SO SURGICAL INFECTIONS
LA English
DT Review
DE general abdominal surgery; negative pressure wound therapy; surgical
   site infection
AB Background: Surgical site infections (SSIs) represent an economic burden to healthcare systems. The use of negative pressure wound therapy (NPWT) for SSI prophylaxis remains uncertain.
   Methods: A systematic literature search was conducted in Medline/PubMed, CINAHL, and Web of Science for relevant studies. The primary outcome was the evaluation of the effectiveness of NPWT for prophylaxis of SSI rates in general abdominal surgery. Secondary outcomes were rates of seroma and wound dehiscence, length of hospital stay, and re-admission rates. The statistical analysis was performed with random effect models.
   Results: A total of 3,193 patients from 20 articles (six randomized controlled trials [RCT], three prospective, eight retrospective, and three ambispective studies) were analyzed. Negative pressure wound therapy was associated with decreased rate of SSIs compared with standard dressing in a pooled analysis of non-randomized studies and RCTs (0.57; 95% confidence interval [CI], -0.4 to 0.8; p < 0.001). This result, however, needs to be challenged because of a significant statistical heterogeneity of the included studies (I-2 = 71%; p < 0.01). A separate analysis of the six RCTs failed to confirm the superiority of NPWT (0.64; 95% CI, -0.4 to 1.04; p = 0.07), also disclosing significant heterogeneity. The analysis of secondary outcomes was only possible in combination of randomized and non-randomized studies because of incomplete datasets in RCTs. Re-admission rates were lower after NPWT and no difference was observed for the incidence of seroma, wound dehiscence, and length of hospital stay.
   Conclusions: Based on available evidence, the routine use of NPWT for SSI prophylaxis after laparotomy in general abdominal surgery cannot be generally recommended.
C1 [Almansa-Saura, Sonia; Lopez-Lopez, Victor; Castellanos-Escrig, Gregorio; Rodriguez-Valiente, Monica; Crespo, Maria Jesus; Robles-Campos, Ricardo] Clin & Univ Hosp Virgen Arrixaca, IMIB ARRIXACA, Dept Gen Visceral & Transplantat Surg, Murcia, Spain.
   [Eshmuminov, Dilmurodjon; Schneider, Marcel; Lehmann, Kuno] Univ Hosp Zurich, Dept Visceral Surg & Transplantat, Zurich, Switzerland.
   [von der Groeben, Markus] Hosp Muri, Dept Surg, Muri, Switzerland.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; University of
   Zurich; University Zurich Hospital
RP Lopez-Lopez, V (通讯作者)，Clin & Univ Hosp Virgen Arrixaca, Dept Gen Visceral & Transplantat Surg, Ctra Madrid Cartagena S-N, Murcia 30120, Spain.
EM victorrelopez@gmail.com
RI Lehmann, Kuno/M-8504-2016; Schneider, Marcel André/AAW-9712-2020;
   Schneider, Marcel/AAW-9712-2020
OI Lehmann, Kuno/0000-0002-6177-9543; Eshmuminov,
   Dilmurodjon/0000-0002-9575-7094; Schneider, Marcel
   André/0000-0002-6723-8879; Robles, Ricardo/0000-0003-0007-562X; 
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NR 39
TC 10
Z9 10
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT 1
PY 2021
VL 22
IS 8
BP 854
EP 863
DI 10.1089/sur.2020.407
EA APR 2021
PG 10
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA YK2DT
UT WOS:000639963900001
PM 33844934
DA 2026-07-24
ER

PT J
AU Liu, X
   Zhang, H
   Li, YX
   Chen, Y
   Deng, W
   Zhang, W
AF Liu, Xi
   Zhang, Hui
   Li, Yaxing
   Chen, Yu
   Deng, Wei
   Zhang, Wen
TI Application of Negative Pressure Wound Therapy in Total Ankle
   Replacement
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE ankle arthroplasty; closed incision; infection; joint replacement; lower
   extremity; negative pressure wound therapy
AB The efficacy and safety of incisional negative pressure wound therapy (iNPWT) was evaluated following total ankle replacement. A retrospective cohort study was conducted in patients who underwent total ankle replacement between January 2010 and June 2018. Following joint replacement, the patients received iNPWT (iNPWT group) or sterile dressings (Control group). Infection rate, wound complication incidence, length of stay, visual analogue scale, American Orthopedic Foot and Ankle Society, and short-form 36 scales, and ankle range of motion were assessed 1 week, 2 weeks, 1 month, 3 months, 6 months, and 12 months postoperatively. Thirty-four patients (n = 13 iNPWT and n = 21 Control) were included. No significant differences were found in baseline data. During follow-up, one Control patient developed a superficial infection at the incision. Wound complications developed in 4 Control patients and 1 iNPWT patient; although this was not statistically significant. Length of stay was similar between the 2 groups. Two weeks after surgery, the range of visual analogue scale (2.1 vs 1.4), American Orthope-dic Foot and Ankle Society (13.7 vs 9.7), and short-form 36 scale (9.0 vs 6.5) improvement, and increase of ankle range of motion (9.2 vs 6.1) was significantly larger in the study group than in the control group (p < .05). Three months to 1 year after the surgery, this difference was no longer statistically significant. The application of iNPWT following total ankle arthroplasty helped reduce postoperative pain, improve ankle function, and improve patient quality of life. However, these benefits were no longer statistically significant 3 months to 1 year after surgery. ? 2020 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Liu, Xi; Zhang, Hui; Li, Yaxing] West China Hosp, Dept Orthoped Surg, 37 Guoxue Ave, Chengdu, Sichuan, Peoples R China.
   [Chen, Yu; Deng, Wei] Shangjin Nanfu Hosp, Dept Orthoped Surg, Chengdu, Sichuan, Peoples R China.
   [Zhang, Wen] Chengdu Univ Tradit Chinese Med, Affiliated Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Chengdu University of Traditional Chinese Medicine
RP Zhang, H (通讯作者)，West China Hosp, Dept Orthoped Surg, 37 Guoxue Ave, Chengdu, Sichuan, Peoples R China.
EM zhanghuishangjin@163.com
RI Zhang, Hui/OTH-2486-2025
CR Agarwal A, 2019, PLAST RECONSTR SURG, V143, p21S, DOI 10.1097/PRS.0000000000005308
   Batra RK, 2014, INDIAN J SURG, V76, P162, DOI 10.1007/s12262-012-0770-7
   Esparragoza L, 2011, J FOOT ANKLE SURG, V50, P383, DOI 10.1053/j.jfas.2011.03.004
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   Ling JS, 2015, J BONE JOINT SURG AM, V97A, P512, DOI 10.2106/JBJS.N.00426
   Matsumoto T, 2015, FOOT ANKLE INT, V36, P787, DOI 10.1177/1071100715574934
   Miller MS, 2005, OSTOMY WOUND MANAG, V51, P44
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   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Sturnick DR, 2017, FOOT ANKLE INT, V38, P1249, DOI 10.1177/1071100717726806
   Surace P, 2019, J ARTHROPLASTY, V34, P426, DOI 10.1016/j.arth.2018.11.015
   Younger ASE, 2015, FOOT ANKLE INT, V36, P253, DOI 10.1177/1071100714558844
NR 23
TC 8
Z9 9
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2021
VL 60
IS 2
BP 283
EP 287
DI 10.1053/j.jfas.2020.08.021
EA MAR 2021
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA RA9EI
UT WOS:000631721500012
PM 33223439
DA 2026-07-24
ER

PT J
AU Abadía, P
   Ocaña, J
   Ramos, D
   Pina, JD
   Moreno, I
   García, JC
   Rodríguez, G
   Tobaruela, E
   Die, J
AF Abadia, Pedro
   Ocana, Juan
   Ramos, Diego
   Pina, Juan D.
   Moreno, Irene
   Garcia, Juan C.
   Rodriguez, Gloria
   Tobaruela, Estela
   Die, Javier
TI Prophylactic Use of Negative Pressure Wound Therapy Reduces Surgical
   Site Infections in Elective Colorectal Surgery: A Prospective Cohort
   Study
SO SURGICAL INFECTIONS
LA English
DT Article
DE coloproctology; hospital stay; negative pressure wound therapy; surgical
   site infection
ID PREVENTION; LAPAROTOMY; TRIAL
AB Background:The main purpose was to assess the efficacy of negative pressure wound therapy (NPWT) for surgical site infection (SSI) in elective open and laparoscopic open-assisted colorectal surgery. The primary end point was to establish SSI within 30 days post-operatively. The secondary aim was hospital stay and to assess SSI predictors in a multivariable analysis. Patients and Methods:A prospective cohort study was undertaken between January 2017 and December 2018 in patients undergoing elective colorectal surgery, both through open and minimally invasive approaches, to whom NPWT or fully occlusive dressing were applied. Baseline data were compared between the two groups and multivariable analysis was performed to identify SSI risk factors. Results:Two hundred patients were included: 100 NPWT patients and 100 closed dressing patients. No differences between the two groups were found. The incidence of SSI in the control dressing group was 19% versus 9% in the NPWT group, which was substantially different (odds ratio [OR] 0.30; 95% confidence interval [CI] 0.11-0.83; p = 0.02). No differences were found in hospital length of stay (12.33 d in NPWT group vs. 12.39 d in the control group; p = 0.82). A body mass index (BMI) of 30-35 (p = 0.04), BMI >35 (p = 0.03), and midline wound (p = 2.68) were found to be predictors of SSI in multivariable analysis. Conclusion:The prophylactic use of NPWT in laparotomy incisions for patients undergoing elective colorectal surgery (both through open and laparoscopic approach) is associated with a reduction in SSI rates.
C1 [Abadia, Pedro; Ocana, Juan; Ramos, Diego; Pina, Juan D.; Moreno, Irene; Garcia, Juan C.; Rodriguez, Gloria; Tobaruela, Estela; Die, Javier] Hosp Univ Ramon y Cajal, Dept Gen & Digest Surg, Div Coloproctol, Madrid, Spain.
C3 Hospital Universitario Ramon y Cajal
RP Ocaña, J (通讯作者)，Hosp Univ Ramon y Cajal, Dept Gen & Digest Surg, Ctra Colmenar Viejo Km 9-100, Madrid 28034, Spain.
EM jocajim@gmail.com
RI ; Ramos, Diego/HSH-4501-2023; Ocaña, Juan/AAN-7494-2021; Moreno Torres,
   Irene del Pilar/AAY-5247-2021
OI die trill, javier/0000-0003-2116-9190; Ramos, Diego/0000-0003-0191-1968;
   Abadía Barnó, Peo/0000-0003-4713-9870; 
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe288, DOI 10.1016/S1473-3099(16)30402-9
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   Webb MA, 2019, AM J SURG, V217, P948, DOI 10.1016/j.amjsurg.2018.12.019
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 28
TC 9
Z9 11
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD MAR 1
PY 2021
VL 22
IS 2
BP 234
EP 239
DI 10.1089/sur.2019.309
EA JUN 2020
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA QO8UL
UT WOS:000539611700001
PM 32522098
DA 2026-07-24
ER

PT J
AU Chotanaphuti, T
   Courtney, PM
   Fram, B
   den Kleef, NJI
   Kim, TK
   Kuo, FC
   Lustig, S
   Moojen, DJ
   Nijhof, M
   Oliashirazi, A
   Poolman, R
   Purtill, JJ
   Rapisarda, A
   Rivero-Boschert, S
   Veltman, ES
AF Chotanaphuti, Thanainit
   Courtney, Paul M.
   Fram, Brianna
   den Kleef, N. J. In
   Kim, Tae-Kyun
   Kuo, Feng-Chih
   Lustig, Sebastien
   Moojen, Dirk-Jan
   Nijhof, Marc
   Oliashirazi, Ali
   Poolman, Rudolf
   Purtill, James J.
   Rapisarda, Antony
   Rivero-Boschert, Salvador
   Veltman, Ewout S.
TI Hip and Knee Section, Treatment, Algorithm: Proceedings of International
   Consensus on Orthopedic Infections
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article; Proceedings Paper
CT 2nd International Consensus Meeting (ICM) on Musculoskeletal Infection
CY JUL 25-27, 2018
CL Philadelphia, PA
DE early postoperative infection; acute hematogenous infection; systemic
   sepsis; surgical bioburden reduction; persistent wound drainage;
   irrigation and debridement; surgical intervention; negative-pressure
   wound therapy; synovectomy; single-stage exchange; infected bilateral
   arthroplasties; infected bilateral hip arthroplasties; infected
   bilateral knee arthroplasties
ID PERIPROSTHETIC JOINT INFECTION; PRESSURE WOUND THERAPY; HEMATOGENOUS
   INFECTION; ARTHROPLASTY; DEBRIDEMENT; DRAINAGE; MALNUTRITION;
   COMPLICATION; REPLACEMENT; IRRIGATION
RI Poolman, Rudolf W/AAM-7815-2020; Kuo, Feng-Chih/W-3327-2019; Kim,
   Tae/AAG-1037-2021; Fram, Brianna/GSJ-0318-2022; Lustig,
   Sébastien/E-3375-2013
OI Poolman, Rudolf W/0000-0003-3178-2247; Kuo,
   Feng-Chih/0000-0001-5205-8333; Fram, Brianna/0000-0002-5888-3008; 
CR [Anonymous], 2013, BONE JOINT J, DOI [DOI 10.1002/JOR.22543, 10.1002/jor.22543]
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NR 56
TC 32
Z9 36
U1 0
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD FEB
PY 2019
VL 34
IS 2
SU S
BP S393
EP S397
DI 10.1016/j.arth.2018.09.024
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA HH1KC
UT WOS:000455477200046
PM 30348575
DA 2026-07-24
ER

PT J
AU Choi, SI
   Park, JC
   Jung, DH
   Shin, SK
   Lee, SK
   Lee, YC
AF Choi, Soo In
   Park, Jun Chul
   Jung, Da Hyun
   Shin, Sung Kwan
   Lee, Sang Kil
   Lee, Yong Chan
TI Efficacy of Endoscopic Vacuum-Assisted Closure Treatment for
   Postoperative Anastomotic Leak in Gastric Cancer
SO GUT AND LIVER
LA English
DT Article
DE Vacuum assisted closure; Anastomotic leak; Gastrectomy; Self-expandable
   metallic stents; Stomach neoplasms
ID ESOPHAGEAL STENT; MANAGEMENT; THERAPY; COMPLICATIONS; GASTRECTOMY;
   SURGERY; FISTULAS
AB Background/Alms: Endoscopic vacuum-assisted closure (EVAC) has been attempted as new nonsurgical treatment for anastomotic leakage. We aimed to evaluate the clinical outcomes of EVAC and compare its efficacy with the self-expandable metallic stent (SEMS) for postgastrectomy leakage. Methods: Between January 2007 and February 2018, 39 patients underwent endoscopic treatment for anastomotic leakage after gastric cancer surgery. Of them, 28 patients were treated with SEMS, seven with EVAC after SEMS failure, and four with EVAC. We retrospectively compared the clinical characteristics and therapeutic outcomes between EVAC (n=11) and SEMS (n=28). Results: The median follow-up duration was 17 months (interquartile range, 9 to 26 months) in both groups. In comparison of clinical characteristics between two groups, only the median size of the leak was larger in the EVAC group than in the SEMS group (2.1 cm vs 1.0 cm; p<0.001). All EVAC cases healed successfully, however, two cases (7.1%) failed to heal in the SEMS group. Anastomotic stricture occurred one case (9.1%) in EVAC and four cases (14.3%) in SEMS within 1 year after endoscopic treatment. The median treatment duration of EVAC was shorter than that of SEMS (15 days vs 36 days; p<0.001). Median weight loss after therapy was similar in both groups (8.0 kg in EVAC vs 9.0 kg in SEMS; p=0.356). Conclusions: EVAC can be effective endoscopic treatment for postgastrectomy anastomotic leakage. Substantial leakage could be an important clinical factor for considering EVAC as a treatment option. Large randomized controlled trials are needed to confirm the efficacy of EVAC.
C1 [Choi, Soo In] Inje Univ, Div Gastroenterol, Dept Internal Med, Sanggye Paik Hosp,Coll Med, Seoul, South Korea.
   [Park, Jun Chul; Jung, Da Hyun; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan] Yonsei Univ, Div Gastroenterol, Dept Internal Med, Severance Hosp,Inst Gastroenterol,Coll Med, Seoul, South Korea.
C3 Inje University; Yonsei University; Yonsei University Health System;
   Severance Hospital
RP Park, JC (通讯作者)，Yonsei Univ, Div Gastroenterol, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03727, South Korea.
EM JUNCHUL75@yuhs.ac
RI ; Park, Jun Chul/H-7218-2019
OI Lee, Yong Chan/0000-0001-8800-6906; Shin, Sung Kwan/0000-0001-5466-1400;
   Park, Jun Chul/0000-0001-8018-0010; Jung, Da Hyun/0000-0001-6668-3113;
   Lee, Sang Kil/0000-0002-0721-0364; Choi, Soo In/0000-0001-6156-5898
CR Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Böhm G, 2010, ENDOSCOPY, V42, P599, DOI 10.1055/s-0029-1244165
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NR 35
TC 11
Z9 16
U1 0
U2 1
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
EI 2005-1212
J9 GUT LIVER
JI Gut Liver
PD NOV
PY 2020
VL 14
IS 6
BP 746
EP 754
DI 10.5009/gnl20114
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA OU6TT
UT WOS:000591659600008
PM 33024061
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, RL
   Zhang, YH
   Hou, LY
   Yan, CY
AF Zhang, Rongli
   Zhang, Yahui
   Hou, Liyuan
   Yan, Chengyong
TI Vacuum-assisted closure versus conventional dressing in necrotizing
   fasciitis: a systematic review and meta-analysis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Review
DE Necrotizing fasciitis; Vacuum-assisted closure; Conventional dressing;
   Meta-analysis
ID PRESSURE WOUND THERAPY; FOURNIERS GANGRENE; INSTILLATION; MANAGEMENT;
   NECK; HEAD
AB BackgroundNecrotizing fasciitis is a rapid and severe soft tissue infection that targets subcutaneous fat tissue, muscle, and fascia. This study compares the clinical outcomes of vacuum-assisted closure (VAC) versus conventional dressing on necrotizing fasciitis.MethodsWe systematically searched Embase, Cochrane, and PubMed for clinical trials (published between January 1, 1995 and September 30, 2021), which compared VAC with conventional dressing for necrotizing fasciitis. The mortality rate of necrotizing fasciitis was the primary outcome of this study. The number of debridements, the total length of hospital stay, and the complication rate were secondary outcomes. A random effects model assessed all pooled data.ResultsA total of 230 identified studies and seven controlled clinical trials met the inclusion criteria and were included in this analysis (n = 249 participants). Compared to the conventional dressing, patients treated with VAC had a significantly lower mortality rate [OR = 0.27, 95% CI (0.09, 0.87)] (P = 0.03). Total length of hospital stays [MD = 8.46, 95% CI (- 0.53, 17.45)] (P = 0.07), number of debridements [MD = 0.86, 95% CI (- 0.58, 2.30)] (P = 0.24), and complication rate [OR = 0.64, 95% CI (0.07, 5.94)] (P = 0.69) were not significant. These results did not show significant differences between both groups treated with VAC or conventional treatment.ConclusionVAC could significantly decrease the death rate compared to conventional dressing. No significant impacts were found on the number of debridements, the total length of hospital stay, and the complication rate in this study.Level of evidence Level-III.Registration Research Registry (reviewregistry1246).
C1 [Zhang, Rongli; Zhang, Yahui; Hou, Liyuan; Yan, Chengyong] Hebei Med Univ, Dept Orthopaed Surg, Hosp 3, Shijiazhuang, Peoples R China.
C3 Hebei Medical University
RP Yan, CY (通讯作者)，Hebei Med Univ, Dept Orthopaed Surg, Hosp 3, Shijiazhuang, Peoples R China.
EM drcyyan@126.com
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NR 34
TC 23
Z9 31
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD FEB 4
PY 2023
VL 18
IS 1
AR 85
DI 10.1186/s13018-023-03561-7
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 8O6KH
UT WOS:000925943300003
PM 36737764
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Domínguez, LP
   Rivera, HP
   Alvarado, NC
   Saco, AL
   Vázquez, AR
   Núñez, EC
AF Perez Dominguez, Lucinda
   Pardellas Rivera, Hermelinda
   Caceres Alvarado, Nieves
   Lopez Saco, Angel
   Rivo Vazquez, Angel
   Casal Nunez, Enrique
TI Vacuum assisted closure in open abdomen and deferred closure: experience
   in 23 patients
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Laparostomy; Open abdomen; Vacuum assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; TEMPORARY
   CLOSURE; FASCIAL CLOSURE; INTERNATIONAL-CONFERENCE; ACUTE-PANCREATITIS;
   DAMAGE-CONTROL; MANAGEMENT; WOUNDS; PRESSURE
AB Introduction: We analyse our experience and the results obtained with the use of vacuum assisted closure (VAC (R), KCI Clinic Spain SL) in the management of open abdomen.
   Material and methods: We retrospectively reviewed the laparostomies performed between June 2006 and March 2011 using VAC (R) treatment in the Hospital Xeral-Cies, Vigo.
   Results: We included 23 consecutive patients (18 males and 5 females) on whom the VAC (R) was used in the open abdomen due to different indications (abdominal trauma, peritonitis, pancreatitis, ischaemic disease or abdominal compartmental syndrome). The VAC (R) needed changing a mean of 3.1 times per patient (range 1-7), with total mean treatment duration of 14.8 days (2-43) until closure, primary closure being achieved in 18 out of 21 patients (86%). The mean hospital stay was 110.1 days (8-163) and 6 patients (26%) died during their hospital stay due to problems related to their underlying disease. Seven cases (30%) had complications during the VAC (R) therapy: 3 intra-abdominal abscesses (13%), 4 fistulas or suture dehiscence (17%), and 1 evisceration (4%).
   Conclusions: VAC (R) therapy is simple to manage, with an acceptable rate of complication, particularly of intestinal fistulas, and a reduced mortality. Of the various systems available for the deferred closure of the abdomen, the VAC (R) has made considerable progress in the past few years, mainly due to its adaptable material, and its numerous advantages. Its use will possibly increase in the future. (c) 2011 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Perez Dominguez, Lucinda; Pardellas Rivera, Hermelinda; Caceres Alvarado, Nieves; Lopez Saco, Angel; Rivo Vazquez, Angel; Casal Nunez, Enrique] Hosp Xeral Cies, Serv Cirugia Gen, Vigo, Pontevedra, Spain.
C3 Complexo Hospitalario Universitario de Vigo
RP Domínguez, LP (通讯作者)，Hosp Xeral Cies, Serv Cirugia Gen, Complexo Hosp Univ Vigo, Vigo, Pontevedra, Spain.
EM lucindaperezdominguez@hotmail.com
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NR 40
TC 12
Z9 16
U1 0
U2 2
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD OCT
PY 2012
VL 90
IS 8
BP 506
EP 512
DI 10.1016/j.ciresp.2012.03.009
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 017SL
UT WOS:000309611200009
PM 22652131
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Didziokaite, G
   Kuznecovaite, A
   Sileikis, A
   Paliulyte, V
AF Didziokaite, Gabija
   Kuznecovaite, Aida
   Sileikis, Audrius
   Paliulyte, Virginija
TI Delayed Diagnosis of Acute Appendicitis in the Third Trimester of
   Pregnancy: Diagnostic Pitfalls, Multisurgical Management, and a
   Prolonged Postoperative Course-A Multidisciplinary Case Report
SO DIAGNOSTICS
LA English
DT Article
DE acute appendicitis; pregnancy; third trimester; perforated appendix;
   postoperative complications; intestinal obstruction; eventration;
   vacuum-assisted closure (VAC)
ID VACUUM-ASSISTED CLOSURE; APPENDECTOMY; THERAPY
AB Background/Objectives: Acute appendicitis is the most common non-obstetric surgical emergency during pregnancy. Diagnosing appendicitis in the third trimester remains especially challenging due to physiological changes that obscure clinical presentation and limit the utility of imaging modalities. These challenges can lead to diagnostic delays, increasing the risk of severe complications for both mother and fetus. Case presentation: We present a complex case of a 36-year-old pregnant woman at 29 + 4 weeks of gestation who developed acute appendicitis with an atypical clinical course. Her initial symptoms were nonspecific and misattributed to gastrointestinal discomfort related to pregnancy. Her condition progressively worsened, leading to an emergency laparoscopic appendectomy. Intraoperative findings confirmed a perforated, necrotic appendix. Postoperatively, she experienced multiple complications, including ileus, wound dehiscence, and complete eventration of the abdominal wall. These required two additional laparotomies and the application of vacuum-assisted closure (VAC) therapy for effective wound management. Despite the severity of maternal complications and the risk of preterm delivery, a multidisciplinary team provided coordinated care. The patient was delivered vaginally at 34 + 4 weeks using vacuum assistance. The neonate, who developed sepsis, was treated in the neonatal intensive care unit and discharged after 24 days. Both mother and child ultimately recovered. Conclusions: This case highlights the diagnostic complexity of appendicitis in late pregnancy and the potential for severe postoperative complications. Prompt surgical intervention, high clinical suspicion, and a multidisciplinary approach are crucial. Moreover, this report adds to the limited literature on the use of VAC therapy for abdominal eventration in pregnancy, demonstrating its feasibility and safety in selected cases.
C1 [Didziokaite, Gabija; Kuznecovaite, Aida; Sileikis, Audrius; Paliulyte, Virginija] Vilnius Univ, Fac Med, LT-01513 Vilnius, Lithuania.
   [Sileikis, Audrius] Vilnius Univ, Inst Clin Med, Fac Med, Clin Gastroenterol Nephro Urol & Surg, LT-01513 Vilnius, Lithuania.
C3 Vilnius University; Vilnius University
RP Didziokaite, G (通讯作者)，Vilnius Univ, Fac Med, LT-01513 Vilnius, Lithuania.
EM didziokaite.gabija@gmail.com; aida.kuznecovaite@mf.stud.vu.lt;
   audrius.sileikis@mf.vu.lt; virginija.paliulyte@mf.vu.lt
RI /Q-5839-2019; Kuznecovaitė, Aida/MAH-0574-2025; Didziokaite,
   Gabija/JCO-4454-2023; Sileikis, Auius/AAJ-1472-2020
OI Kuznecovaitė, Aida/0009-0001-6846-6670; Didziokaite,
   Gabija/0000-0002-9742-7179; Sileikis, Auius/0000-0001-9313-0581
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NR 50
TC 0
Z9 0
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD OCT 14
PY 2025
VL 15
IS 20
AR 2593
DI 10.3390/diagnostics15202593
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9BT4V
UT WOS:001602569300001
PM 41153265
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, HQ
   Sun, SN
   Wang, GH
   Huang, QB
   Zhang, ZL
AF Wang, Huaqing
   Sun, Shengnan
   Wang, Guanghui
   Huang, Qibing
   Zhang, Zeli
TI Analysis of Vacuum-Assisted Closure-Assisted Antibiotic Irrigation in
   Treatment of Severe Neurosurgical Central Nervous System Infections
SO SURGICAL INFECTIONS
LA English
DT Article
DE antibiotic irrigation; debridement; outcomes; severe neurosurgical
   central nervous system infections; vacuum-assisted closure
ID DERMAL REGENERATION TEMPLATE; WOUND THERAPY; SCALP; RECONSTRUCTION;
   VENTRICULITIS
AB Objective: Severe neurosurgical central nervous system infections (sNCNSIs) are among the most serious complications of neurosurgical disease. Conventional methods have shown a poor prognosis. This study aims to analyze the clinical characteristics of vacuum-assisted closure (VAC) in sNCNSIs with the help of antibiotic irrigation treatment.Patients and Methods: A retrospective study was performed for patients diagnosed with sNCNSIs. A VAC device was placed on the incision after debridement and the surgical cavity was rinsed with antibiotic agents in the VAC group. Meanwhile the surgical cavity was drained after debridement in the control group. Medical data were reviewed and analyzed.Results: Twenty-eight patients met the inclusion criteria, including 18 cases in the VAC group and 10 cases in the control group. The basic medical data showed no differences. Bacteria was isolated from 24 (85.7%) patients. The cure rate was significantly higher in the VAC group (p < 0.05). The cure rate in patients with multi-drug-resistant (MDR) infections was significantly higher in patients treated with VAC therapy (p < 0.05). The prognosis evaluated by Glasgow Outcome Score (GOS) between the two groups showed significant difference (p < 0.05). No re-infection in the VAC group occurred in the follow-up period.Conclusions: It is suggested that VAC-assisted antibiotic irrigation is safe and effective for patients with severe NCNSIs and can improve the prognosis dramatically. The results can provide a new effective and reasonable therapeutic strategy for patients with sNCNSIs.
C1 [Wang, Huaqing; Wang, Guanghui; Huang, Qibing; Zhang, Zeli] Shandong Univ, Qilu Hosp, Dept Emergency, Neurosurg Intens Care Unit, Jinan, Shandong, Peoples R China.
   [Wang, Huaqing; Wang, Guanghui; Huang, Qibing; Zhang, Zeli] Shandong Univ, Brain Sci Res Inst, Jinan, Shandong, Peoples R China.
   [Sun, Shengnan] Shandong Med Coll, Dept Nursing, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Huang, QB; Zhang, ZL (通讯作者)，Shandong Univ, Qilu Hosp, Dept Emergency, Neurosurg Intens Care Unit, Jinan, Shandong, Peoples R China.; Huang, QB; Zhang, ZL (通讯作者)，Shandong Univ, Brain Sci Res Inst, Jinan, Shandong, Peoples R China.
EM qibingqilu@126.com; zelishandong@126.com
RI Wang, Guanghui/GWC-6635-2022
FU National Natural Science Foundation of China [82171362]; Natural Science
   Foundation of Shandong Province [ZR2021MH366]
FX This study was supported by National Natural Science Foundation of China
   (grant no. 82171362) and Natural Science Foundation of Shandong Province
   (grant no.ZR2021MH366)
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV 1
PY 2023
VL 24
IS 9
BP 803
EP 810
DI 10.1089/sur.2023.129
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA Z2CA4
UT WOS:001110198000013
PM 37910866
DA 2026-07-24
ER

PT J
AU Everett, CB
   Thomas, BW
   Moncure, M
AF Everett, Christopher B.
   Thomas, Bruce W.
   Moncure, Michael
TI Internal vacuum-assisted closure device in the swine model of severe
   liver injury
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Liver trauma; Negative-pressure therapy; Swine model; Hemorrhage
ID FIBRIN SEALANT DRESSINGS; REDUCE BLOOD-LOSS; INTRAABDOMINAL PRESSURE;
   HEPATIC-INJURY; VENOUS HEMORRHAGE; FASCIAL CLOSURE; DAMAGE CONTROL;
   MANAGEMENT; SURVIVAL; PACKING
AB Objectives: The authors present a novel approach to nonresectional therapy in major hepatic trauma utilizing intraabdominal perihepatic vacuum assisted closure (VAC) therapy in the porcine model of Grade V liver injury.
   Methods: A Grade V injury was created in the right lobe of the liver in a healthy pig. A Pringle maneuver was applied (4.5 minutes total clamp time) and a vacuum assisted closure device was placed over the injured lobe and connected to suction. The device consisted of a perforated plastic bag placed over the liver, followed by a 15 cm by 15cm VAC sponge covered with a nonperforated plastic bag. The abdomen was closed temporarily. Blood loss, cardiopulmonary parameters and bladder pressures were measured over a one-hour period. The device was then removed and the animal was euthanized.
   Results: Feasibility of device placement was demonstrated by maintenance of adequate vacuum suction pressures and seal. VAC placement presented no major technical challenges. Successful control of ongoing liver hemorrhage was achieved with the VAC. Total blood loss was 625 ml (20ml/kg). This corresponds to class II hemorrhagic shock in humans and compares favorably to previously reported estimated blood losses with similar grade liver injuries in the swine model. No post-injury cardiopulmonary compromise or elevated abdominal compartment pressures were encountered, while hepatic parenchymal perfusion was maintained.
   Conclusion: These data demonstrate the feasibility and utility of a perihepatic negative pressure device for the treatment of hemorrhage from severe liver injury in the porcine model.
C1 [Everett, Christopher B.; Thomas, Bruce W.] Univ Kansas, Sch Med, Dept Surg, Wichita, KS 67214 USA.
   [Moncure, Michael] Univ Kansas, Med Ctr, Dept Surg, Kansas City, KS 66103 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center
RP Thomas, BW (通讯作者)，Univ Kansas, Sch Med, Dept Surg, 929 N St Francis St, Wichita, KS 67214 USA.
EM forfeem@gmail.com
FU Kansas University Medical Center; Wesley Medical Center Trauma Research
   Fund
FX This study was funded in part by funds from the Kansas University
   Medical Center, and the Wesley Medical Center Trauma Research Fund.
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NR 39
TC 1
Z9 1
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD DEC 5
PY 2012
VL 7
AR 38
DI 10.1186/1749-7922-7-38
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 073BF
UT WOS:000313717500001
PM 23217091
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Czymek, R
   Schmidt, A
   Eckmann, C
   Bouchard, R
   Wulff, B
   Laubert, T
   Limmer, S
   Bruch, HP
   Kujath, P
AF Czymek, Ralf
   Schmidt, Andreas
   Eckmann, Christian
   Bouchard, Ralf
   Wulff, Birgit
   Laubert, Tillmann
   Limmer, Stefan
   Bruch, Hans-Peter
   Kujath, Peter
TI Fournier's gangrene: vacuum-assisted closure versus conventional
   dressings
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fournier's gangrene; Vacuum-assisted closure; VAC; Necrotizing
   fasciitis; Fecal diversion
ID HYPERBARIC-OXYGEN THERAPY; NECROTIZING FASCIITIS; MALE GENITALIA; TISSUE
   GAS; MANAGEMENT; SCROTUM; INFECTIONS; DISEASE; BACTERIOLOGY; DIAGNOSIS
AB BACKGROUND: Fournier's gangrene is a fulminant and destructive inflammation of the scrotum, penis, and perineum. The objective of this study was to compare 2 different approaches to wound management after aggressive surgical debridement.
   METHODS: Data from 35 patients with Fournier's gangrene were prospectively collected (1996-2007). Once the patients were stabilized following surgery, they were treated with either daily antiseptic (polyhexanide) dressings (group I, n = 16) or vacuum-assisted closure (VAC) therapy (group II, n = 19).
   RESULTS: The mean age of the patients was 58.2 years in group I and 57.2 years in group II. In both groups, the most common predisposing conditions were diabetes mellitus, chronic alcoholism, and obesity. Escherichia coli, streptococcal species, Pseudomonas aeruginosa, and Staphylococcus aureus were the most frequently isolated organisms. Length of hospital stay was 27.8 days 27.6 days (mortality: 37.5%) in group I and 96.8 days 77.2 days (mortality: 5.3%) in group II. Enterostornies were performed in 43.8% of group I patients and in 89.5% of group II patients.
   CONCLUSIONS: VAC was associated with significantly longer hospitalization and lower mortality. A partial explanation is that some patients with severe sepsis died within the first 3 days after admission and thus could not undergo vacuum therapy. Since our clinical experience has shown that vacuum dressings are particularly effective in the management of large wounds, we use VAC primarily for this indication despite the considerable material requirements involved. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Czymek, Ralf; Schmidt, Andreas; Eckmann, Christian; Bouchard, Ralf; Wulff, Birgit; Laubert, Tillmann; Limmer, Stefan; Bruch, Hans-Peter; Kujath, Peter] Univ Lubeck, Sch Med, Dept Surg, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Czymek, R (通讯作者)，Univ Lubeck, Sch Med, Dept Surg, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM ralf.czymek@uk-sh.de
RI /E-7731-2010
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NR 48
TC 76
Z9 88
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2009
VL 197
IS 2
BP 168
EP 176
DI 10.1016/j.amjsurg.2008.07.053
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 408SA
UT WOS:000263454000008
PM 19185110
DA 2026-07-24
ER

PT J
AU Xing, YH
   Lv, R
   Xie, C
   Cao, WJ
   Dou, JY
   Jiang, XC
   Wang, WF
   Wang, ZY
   Ding, ZG
   Qiu, XL
   Tang, L
AF Xing, Yihui
   Lv, Ran
   Xie, Chen
   Cao, Wenjuan
   Dou, Jiayi
   Jiang, Xiaochen
   Wang, Weifeng
   Wang, Ziyang
   Ding, Zhiguo
   Qiu, Xueling
   Tang, Lu
TI Premixed nitrous oxide/oxygen analgesia for removal of vacuum assisted
   closure dressing: a randomized, double-blinded placebo-controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Nitrous oxide; Analgesia; Vacuum assisted closure; Procedure pain
ID PRESSURE WOUND THERAPY; OPEN FRACTURES; OXIDE; PAIN; SEDATION; IMPACT;
   PATIENT; ANESTHESIOLOGY; GUIDELINES; ENTONOX(R)
AB Vacuum assisted closure (VAC) is commonly used in clinical practice to promote wound healing. During the dressing removal of VAC, patients may suffer from different degrees of pain, or even discontinue treatment due to severe pain. Our study sought to determine whether or not nitrous oxide analgesia decreases pain compared to oxygen placebo during removal of VAC dressing. This study is a double-blind, placebo-controlled randomized trial targeting patients who underwent replacement of VAC dressings in orthopedics. All patients were randomized in a 1:1 ratio to receive 65% premixed nitrous oxide/oxygen versus 100% oxygen. The primary outcome was the intensity of pain during the intervention. Secondary outcomes included adverse effects, satisfaction of patients, and physiological parameters (blood pressure, heart rate, oxygen saturation). Between 18 February, 2022 and 9 May, 2023, 114 participants were enrolled, 57 patients were allocated to the intervention group (premixed nitrous oxide/oxygen), 57 patients were enrolled in the control group (oxygen). The baseline and procedural characteristics were comparable between the two groups. The pain score reported by patients immediately after removing the dressing in the intervention group was significantly lower than that in the control group (median 3.0 vs. 6.3, P < 0.001). The satisfaction of patients in the intervention group significantly increased (Z=-6.861, P < 0.001). There were no significant differences in vital signs, operation duration, and adverse reactions between the two groups. Premixed nitrous oxide/oxygen can reduce the pain caused by removal VAC dressing in patients and can be considered an effective analgesic measure.
C1 [Xing, Yihui; Cao, Wenjuan; Dou, Jiayi; Jiang, Xiaochen; Wang, Weifeng; Wang, Ziyang; Qiu, Xueling; Tang, Lu] 960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
   [Xing, Yihui] Qingdao Stomatlolg Hosp, Qingdao, Peoples R China.
   [Lv, Ran] Shandong Univ, Sch Nursing & Rehabil, Jinan, Peoples R China.
   [Xie, Chen] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
   [Cao, Wenjuan; Dou, Jiayi; Jiang, Xiaochen; Wang, Weifeng; Wang, Ziyang] Shandong Second Med Univ, Sch Nursing, Weifang, Peoples R China.
   [Ding, Zhiguo] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China.
C3 Shandong University; Shandong Second Medical University; Qingdao
   Municipal Hospital
RP Tang, L (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Stomatol, Jinan 250031, Peoples R China.
EM tanglu_office@163.com
FU clinical medical science and technology innovation project of Jinan
   [202019025]
FX This study was supported by clinical medical science and technology
   innovation project of Jinan (Grant number: 202019025).
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NR 59
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 21
PY 2026
VL 16
IS 1
AR 18409
DI 10.1038/s41598-026-46571-1
EA APR 2026
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JM5TA
UT WOS:001792890100003
PM 42009792
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Rajabaleyan, P
   Michelsen, J
   Holst, UT
   Möller, S
   Toft, P
   Luxhoi, J
   Buyukuslu, M
   Bohm, AM
   Borly, L
   Sandblom, G
   Kobborg, M
   Poulsen, KA
   Love, US
   Ovesen, S
   Solling, CG
   Sondergaard, BM
   Lomholt, ML
   Moller, DR
   Qvist, N
   Ellebæk, MB
AF Rajabaleyan, Pooya
   Michelsen, Jens
   Tange Holst, Uffe
   Moller, Soren
   Toft, Palle
   Luxhoi, Jan
   Buyukuslu, Musa
   Bohm, Aske Mathias
   Borly, Lars
   Sandblom, Gabriel
   Kobborg, Martin
   Aagaard Poulsen, Kristian
   Schou Love, Uffe
   Ovesen, Sophie
   Grant Solling, Christoffer
   Morch Sondergaard, Birgitte
   Lund Lomholt, Marianne
   Ritz Moller, Dorthe
   Qvist, Niels
   Bremholm Ellebaek, Mark
CA VACOR Study Grp
TI Vacuum-assisted closure versus on-demand relaparotomy in patients with
   secondary peritonitis-the VACOR trial: protocol for a randomised
   controlled trial
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Secondary peritonitis; Faecal peritonitis; Vacuum-assisted closure;
   Primary abdominal closure; Relaparotomy on-demand
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; NEGATIVE-PRESSURE; POSTOPERATIVE
   PERITONITIS; PLANNED RELAPAROTOMY; ABDOMINAL SEPSIS; MANAGEMENT;
   CLASSIFICATION; PREDICTORS; MORBIDITY
AB Background Secondary peritonitis is a severe condition with a 20-32% reported mortality. The accepted treatment modalities are vacuum-assisted closure (VAC) or primary closure with relaparotomy on-demand (ROD). However, no randomised controlled trial has been completed to compare the two methods potential benefits and disadvantages. Methods This study will be a randomised controlled multicentre trial, including patients aged 18 years or older with purulent or faecal peritonitis confined to at least two of the four abdominal quadrants originating from the small intestine, colon, or rectum. Randomisation will be web-based to either primary closure with ROD or VAC in blocks of 2, 4, and 6. The primary endpoint is peritonitis-related complications within 30 or 90 days and one year after index operation. Secondary outcomes are comprehensive complication index (CCI) and mortality after 30 or 90 days and one year; quality of life assessment by (SF-36) after three and 12 months, the development of incisional hernia after 12 months assessed by clinical examination and CT-scanning and healthcare resource utilisation. With an estimated superiority of 15% in the primary outcome for VAC, 340 patients must be included. Hospitals in Denmark and Europe will be invited to participate. Discussion There is no robust evidence for choosing either open abdomen with VAC treatment or primary closure with relaparotomy on-demand in patients with secondary peritonitis. The present study has the potential to answer this important clinical question.
C1 [Rajabaleyan, Pooya; Tange Holst, Uffe; Aagaard Poulsen, Kristian; Qvist, Niels; Bremholm Ellebaek, Mark] Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
   [Michelsen, Jens; Toft, Palle] Odense Univ Hosp, Res Unit Anaesthesiol, Odense, Denmark.
   [Moller, Soren] Odense Univ Hosp, Open Patient Data Explorat Network, OPEN, Odense, Denmark.
   [Moller, Soren] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
   [Luxhoi, Jan; Buyukuslu, Musa] Hosp Southwest Jutland, Surg Dept, Esbjerg, Denmark.
   [Bohm, Aske Mathias; Borly, Lars] Holbaek Cent Hosp, Surg Dept, Holbaek, Denmark.
   [Sandblom, Gabriel] Karolinska Inst, Stockholm, Sweden.
   [Kobborg, Martin] Kolding Cty Hosp, Surg Dept, Kolding, Denmark.
   [Schou Love, Uffe; Ovesen, Sophie; Grant Solling, Christoffer; Morch Sondergaard, Birgitte] Viborg Hosp, Surg Dept, Viborg, Denmark.
   [Lund Lomholt, Marianne; Ritz Moller, Dorthe] Aarhus Univ Hosp, Surg Dept, Aarhus, Denmark.
   [Rajabaleyan, Pooya; Michelsen, Jens; Tange Holst, Uffe; Toft, Palle; Aagaard Poulsen, Kristian; Qvist, Niels; Bremholm Ellebaek, Mark] Univ Southern Denmark, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; University of Southern Denmark;
   Holbaek Hospital; Karolinska Institutet; Kolding Hospital; Aarhus
   University; Viborg City Hospital; Aarhus University; University of
   Southern Denmark
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Res Unit Surg, Odense, Denmark.
EM Pooya.rajabaleyan@rsyd.dk
RI Michelsen, Jens/QAY-7340-2026; Ellebaek, Mark Bremholm/ADW-1803-2022;
   Möller, Sören/X-8738-2019
OI Michelsen, Jens/0000-0002-1244-6072; Løve, Uffe
   Schou/0000-0002-2409-0499; Ellebaek, Mark Bremholm/0000-0001-6550-7505;
   Rajabaleyan, Pooya/0000-0002-6882-9427; Toft, Palle/0000-0002-3188-449X;
   Sølling, Christoffer/0000-0003-0721-926X; Möller,
   Sören/0000-0003-0858-4269
FU University of Southern Denmark; Region of Southern Denmark; Novo Nordisk
   Foundation [NNF19OC0058637, A301]; University of Southern Denmark,
   Campusvej, Odense M, Denmark; Region of Southern Denmark, Damhaven,
   Vejle, Denmark; Novo Nordisk Foundation, Tuborg Havnevej, Hellerup,
   Denmark
FX The study is funded by the University of Southern Denmark, Region of
   Southern Denmark, and Novo Nordisk Foundation (Grant Nos.
   NNF19OC0058637, NNF19OC0058637, A301). Trial Sponsor: University of
   Southern Denmark, Campusvej 55, 5230 Odense M, Denmark, Email:
   sdu@sdu.dk, Region of Southern Denmark, Damhaven 12, 7100 Vejle,
   Denmark, and Novo Nordisk Foundation, Tuborg Havnevej 19, 2900 Hellerup,
   Denmark, Email: info@novonordiskfonden.dk.The sponsors have no influence
   on the study design or interpretation of data.
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NR 64
TC 8
Z9 19
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD MAY 26
PY 2022
VL 17
IS 1
AR 25
DI 10.1186/s13017-022-00427-x
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 1U7WQ
UT WOS:000805618500003
PM 35619144
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Deng, ZM
   Cai, L
   Jin, W
   Ping, AS
   Wei, RX
AF Deng, Zhouming
   Cai, Lin
   Jin, Wei
   Ping, Ansong
   Wei, Renxiong
TI One-stage reconstruction with open bone grafting and vacuum-assisted
   closure for infected tibial non-union
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE vacuum-assisted closure; Papineau technique; tibial non-union; infected
ID SOFT-TISSUE TRANSFER; NON-UNION; SEGMENTAL DEFECTS; CHRONIC
   OSTEOMYELITIS; PAPINEAU TECHNIQUE; THERAPY; MANAGEMENT; ILIZAROV;
   WOUNDS; FRACTURES
AB Introduction: Non-union of the tibia complicated by osteomyelitis is one of the most challenging problems in orthopaedic surgery. There remains a significant amount of debate and controversy regarding the optimal medical management of infected tibial non-union. There are few articles which have reported the outcomes of treatment for infected non-union of tibia from single-stage reconstruction with open bone grafting plus vacuum-assisted closure (VAC).
   Material and methods: Our report covers experience between March 2007 and February 2010 of open bone grafting plus VAC in one stage for patients with infected tibial non-union. The time for bone union and wound healing to occur, the duration of hospitalisation, and the rate of resolution of infection were all analysed. The main outcome measures were based on a clinical scoring system that assessed functional ability, range of knee and ankle motion, shortening, infection and pain. Fifteen patients were involved in this study.
   Results: All patients were followed up for an average of 22.6 months (range: 14-42 months). Bone union was achieved in 93.3% (14/15) of patients after a mean of 5.93 months (range: 3-10 months). All wounds healed within an average period of 5 weeks (range: 3-10 weeks), and the function and appearance of all limbs were satisfactory.
   Conclusions: Open bone grafting combined with VAC in a one-stage procedure can be a feasible alternative to the treatment of infected tibial non-union, especially for those wounds which are not good candidates for microsurgery; however, further studies are required to confirm the likely benefits.
C1 [Deng, Zhouming; Cai, Lin; Jin, Wei; Ping, Ansong; Wei, Renxiong] Wuhan Univ, Zhongnan Hosp, Dept Orthopaed, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University
RP Cai, L (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthopaed, 169 Donghu Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM guke3559@yahoo.com.cn
RI Ping, An/GRJ-3145-2022; Li, Caiting/ABD-6818-2021
FU Fundamental Research Funds for the Central Universities [2012303020207]
FX This study was supported by the Fundamental Research Funds for the
   Central Universities (No. 2012303020207)
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NR 40
TC 20
Z9 24
U1 0
U2 10
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD AUG
PY 2014
VL 10
IS 4
BP 764
EP 772
DI 10.5114/aoms.2013.34411
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AO3YW
UT WOS:000341274400019
PM 25276163
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chang, EI
   Festekjian, JH
   Miller, TA
   Ardehali, A
   Rudkin, GH
AF Chang, Eric I.
   Festekjian, Jaco H.
   Miller, Timothy A.
   Ardehali, Abbas
   Rudkin, George H.
TI Chest Wall Reconstruction for Sternal Dehiscence After Open Heart
   Surgery
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal dehiscence; poststernotomy mediastinitis; chest wall
   reconstruction
ID VACUUM-ASSISTED CLOSURE; GREATER OMENTUM; WOUND COMPLICATIONS;
   STERNOTOMY WOUNDS; TRANSPOSITION; MEDIASTINITIS; MANAGEMENT; FLAP;
   IRRIGATION; INFECTION
AB Background: Sternal dehiscence is a grave complication after open heart surgery. Sternal debridement and flap coverage are the mainstays of therapy, but no consensus exists regarding the appropriate level of debridement. More recently, the use of vacuum-assisted closure devices has been advocated as a bridge to definitive closure, but indications for use remain incompletely defined.
   Materials and Methods: A retrospective review of all chest wall reconstructions performed from January 2000 to December 2010 was conducted. The type of operative management was evaluated to assess morbidity, mortality, and length of hospital stay.
   Results: Fifty-four patients underwent chest wall reconstruction for post-sternotomy mediastinitis. Of these patients, 24 underwent conservative sternal debridement with flap closure, 24 underwent radical sternectomy including resection of the costal cartilages followed by flap closure, and 6 underwent radical sternectomy with vacuum-assisted closure therapy followed by flap closure in a delayed fashion. There were 15 patients in the conservative group and 8 patients in the radical sternectomy group who developed postoperative complications (62.5% vs 33.3%, P < 0.05). The conservative sternectomy group had more serious complications requiring reoperation compared to the radical sternectomy group (86.7% vs 25.0%, P < 0.05). The most common complication in the former group was flap dehiscence (8/15, 53.3%), whereas that in the latter group was a superficial wound infection (6/8, 75.0%). There was no significant difference in mortality (25.0% vs 25.0%, P > 0.05%) or length of hospital stay.
   Conclusions: Radical sternectomy including the costal cartilages is associated with lower rates of surgical morbidity and reoperation, but not mortality.
C1 [Chang, Eric I.; Festekjian, Jaco H.; Miller, Timothy A.; Rudkin, George H.] Univ Calif Los Angeles, Med Ctr, Div Plast & Reconstruct Surg, Los Angeles, CA 90095 USA.
   [Ardehali, Abbas] Univ Calif Los Angeles, Med Ctr, Div Cardiothorac Surg, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center
RP Rudkin, GH (通讯作者)，Univ Calif Los Angeles, Med Ctr, Div Plast & Reconstruct Surg, 200 UCLA Med Plaza,Suite 465, Los Angeles, CA 90095 USA.
EM eichang@hotmail.com
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NR 33
TC 11
Z9 14
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2013
VL 71
IS 1
BP 84
EP 87
DI 10.1097/SAP.0b013e31824872d9
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300EC
UT WOS:000330446200022
PM 23123614
DA 2026-07-24
ER

PT J
AU Christensen, TJ
   Thorum, T
   Kubiak, EN
AF Christensen, Thomas J.
   Thorum, Troy
   Kubiak, Erik N.
TI Lidocaine Analgesia for Removal of Wound Vacuum-Assisted Closure
   Dressings: A Randomized Double-Blinded Placebo-Controlled Trial
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE wound vacuum-assisted closure dressing; soft-tissue management; pain
   management
ID PRESSURE; MANAGEMENT; ANESTHESIA; SYSTEM
AB Objectives: Wound vacuum-assisted closure (VAC) is a technique used frequently by orthopedic surgeons to facilitate wound closure. Bedside VAC removal can be a source of great pain for patients, which we hypothesize can be decreased by topical lidocaine application.
   Design: This was a prospective randomized double-blinded, placebo-controlled trial (registered on clinicaltrials.gov), utilizing the crossover intervention technique.
   Setting: The study was carried out at a level 1 trauma center.
   Patients/Participants: Nondiabetic, adult patients requiring at least 2 extremity wound VAC dressing changes were involved.
   Intervention: In a double-blinded fashion, topical lidocaine (1%) was compared with topical normal saline (0.9% NaCl) after injection into the VAC sponge. The crossover intervention technique, wherein each patient received an independent VAC change with lidocaine and saline, served to control for all possible patient characteristics. Randomization determined which sample was given first or second.
   Main Outcome Measurements: The patients were evaluated for visual analog pain scores, narcotic requirement, and wound characteristics.
   Results: A total of 11 patients were enrolled for a total of 21 VAC changes (mean wound size 133 cm(2)); 1 patient withdrew after his first VAC dressing was changed with saline. Controlling for pre-VAC change pain, the lidocaine intervention was associated with 2.4 points less on the 0-10 visual analog scale for pain (P value <0.001, -3.0 to -1.7) and 1.7 mg less morphine-equivalents administered (P value <0.001, -2.3 to -1.1) during the VAC sponge removal.
   Conclusions: The patients undergoing an extremity wound VAC dressing removal at the bedside should be pretreated with topical lidocaine because it decreases pain and narcotic requirements.
C1 [Christensen, Thomas J.; Thorum, Troy; Kubiak, Erik N.] Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah
RP Kubiak, EN (通讯作者)，590 Wakara Way, Salt Lake City, UT 84108 USA.
EM erik.kubiak@hsc.utah.edu
FU NIH National Center for Research Resources [5UL1 RR025764]
FX The statistical analysis was supported by grant number 5UL1 RR025764
   from the NIH National Center for Research Resources.
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NR 26
TC 18
Z9 32
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD FEB
PY 2013
VL 27
IS 2
BP 107
EP 112
DI 10.1097/BOT.0b013e318251219c
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 077VV
UT WOS:000314058300014
PM 23343829
DA 2026-07-24
ER

PT J
AU Damiani, G
   Pinnarelli, L
   Sommella, L
   Tocco, MP
   Marvulli, M
   Magrini, P
   Ricciardi, W
AF Damiani, G.
   Pinnarelli, L.
   Sommella, L.
   Tocco, M. P.
   Marvulli, M.
   Magrini, P.
   Ricciardi, W.
TI Vacuum-assisted closure therapy for patients with infected sternal
   wounds: A meta-analysis of current evidence
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Vacuum-assisted closure therapy; VAC and traditional therapy; VAC and
   standard moist wound therapy; VAC mortality; VAC length of stay;
   Negative pressure therapy and mortality
ID NOSOCOMIAL INFECTION; SUCTION DRAINAGE; MANAGEMENT; MULTICENTER; IMPACT;
   STAY; COST
AB Acute and chronic wound infections are the main reasons for the observed increase in mortality rate and represent a significant risk factor in hospitalisation. From the patient's perspective, wound therapy is an uncomfortable, painful and long-term treatment. Modern sternal-wound-treatment systems would be expected to shorten wound healing and hospital stay periods.
   Vacuum-assisted closure (VAC) therapy is a system that promotes wound healing through the application of negative pressure by controlled suction to the wound surface. The application of controlled levels of negative pressure accelerates healing in many types of wounds.
   There are a number of scientific publications that have used meta-analysis to compare VAC and traditional therapy, considering changes in wound size. This article surveys the research literature focussing on the management of wound infections.
   The objective of this study is to assess the impact of VAC compared with conventional therapy on length of stay (LOS) and mortality.
   Six articles were selected that included a total of 321 patients (169 for VAC therapy and 152 for conventional therapy).
   The meta-analysis showed that VAC therapy resulted in a decrease of 7.18 days in hospital LOS (confidence interval (CI) 95%: 10.82, 3.54), with no significant impact on mortality.
   Our data provide robust evidence of the effectiveness of VAC therapy. (C) 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Damiani, G.; Marvulli, M.; Ricciardi, W.] Univ Cattolica Sacro Cuore, Dept Publ Hlth, I-00168 Rome, Italy.
   [Pinnarelli, L.; Sommella, L.; Tocco, M. P.; Magrini, P.] San Filippo Neri Hosp Trust, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; San
   Filippo Neri Hospital
RP Damiani, G (通讯作者)，Univ Cattolica Sacro Cuore, Dept Publ Hlth, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM gdamiani@rm.unicatt.it
RI Damiani, Gianfranco/K-2782-2016; Pinnarelli, Luigi/K-5673-2016;
   Ricciardi, Walter/AAB-2056-2019
OI Damiani, Gianfranco/0000-0003-3028-6188; Pinnarelli,
   Luigi/0000-0002-9282-0617; Ricciardi, Walter/0000-0002-5655-688X
CR [Anonymous], REV MAN REVMAN COMP
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NR 24
TC 57
Z9 66
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2011
VL 64
IS 9
BP 1119
EP 1123
DI 10.1016/j.bjps.2010.11.022
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 809QU
UT WOS:000294072600008
PM 21256819
DA 2026-07-24
ER

PT J
AU Andrews, BT
   Smith, RB
   Chang, KE
   Scharpf, J
   Goldstein, DP
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Chang, Kristi E.
   Scharpf, Joseph
   Goldstein, David P.
   Funk, Gerry F.
TI Management of the radial forearm free flap donor site with the
   vacuum-assisted closure (VAC) system
SO LARYNGOSCOPE
LA English
DT Article
DE vacuum-assisted closure; VAC; topical negative pressure dressing;
   bolster dressing; radial forearm free flap donor site; split-thickness
   skin graft
ID SECURING SKIN-GRAFTS; WOUND CONTROL; MORBIDITY; COMPLICATIONS; COVERAGE
AB Introduction: The radial forearm free flap is a popular reconstructive flap in modern head and neck surgery. Poor wound healing at the forearm donor site is common and frequently results in tendon exposure. The Vacuum-Assisted Closure (VAC) system (Kinetic Concepts Inc., San Antonio, TX) is a topical negative pressure dressing that has been shown to improve skin graft viability when used as a bolster dressing. In this study, we investigated the use of the VAC system in the management of the radial forearm free flap donor site. Methods. A retrospective chart review was performed on all subjects who underwent a radial forearm free flap reconstruction in which the VAC system was used as a bolster dressing at the donor site from January 1, 2003, through March 31, 2005. Results: Thirty-four consecutive subjects were included in the study. Exposed tendon did not occur in 14 (0%) subjects in which the VAC bolster was used for a minimum of 6 days. Eleven of the 20 subjects (55%) who used the VAC bolster for 5 days demonstrated small amounts of tendon exposure (<2 cm) on follow-up clinic examination. The minimum follow up for all subjects was 4 months. Conclusion: This study demonstrates that the VAC system is a feasible alternative to conventional bolster dressing in the management of the radial forearm free flap skin-grafted donor site. Based on this study, when used for a minimum of 6 days, the VAC bolster dressing eliminated tendon exposure at the forearm donor site.
C1 Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Funk, GF (通讯作者)，Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, 21272 Pomerantz Pavill,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM gerry-funk@uiowa.edu
RI goldstein, David/AAT-6302-2020
OI Andrews, Brian/0000-0003-3994-6808; Chang, Kristi/0000-0002-8083-7497
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARDSLEY AF, 1990, PLAST RECONSTR SURG, V86, P287, DOI 10.1097/00006534-199008000-00014
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NR 20
TC 45
Z9 48
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0023-852X
J9 LARYNGOSCOPE
JI Laryngoscope
PD OCT
PY 2006
VL 116
IS 10
BP 1918
EP 1922
DI 10.1097/01.mlg.0000235935.07261.98
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 090ER
UT WOS:000240933900037
PM 17003705
DA 2026-07-24
ER

PT J
AU Yadav, AK
   Mishra, S
   Khanna, V
   Panchal, S
   Modi, N
   Amin, S
AF Yadav, Amit Kumar
   Mishra, Shaswat
   Khanna, Vikram
   Panchal, Sameer
   Modi, Nihar
   Amin, Stavan
TI Comparative study of various dressing techniques in diabetic foot ulcers
   in the Indian population: a single-center experience
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Diabetic foot ulcer; Vacuum-assisted closure; Foam dressing;
   Conventional dressing; Cost-effective; Hospital stay
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; MULTICENTER
AB Introduction:A prospective randomized study was conducted to evaluate and compare the efficacy of conventional dressing, foam dressing, and vacuum-assisted closure (VAC) in the management of diabetic foot ulcers (DFUs). Material and methods:Ninety patients with DFU were included in the study conducted between 2018 and 2021 at a tertiary care center. Group 1 patients (n = 30) were treated with conventional dressing, group 2 patients (n = 30) with foam dressing, and group 3 patients (n = 30) with VAC dressing. The duration of treatment, number of debridement, need for the secondary procedure, cost of treatment, and duration of hospital stay were compared between the three groups. Results:There was a significant difference in the duration of treatment among the three groups with VAC being the least (group 1, 31.17 days; group 2, 24.13 days; group 3, 15.17 days). The mean number of debridement was also significantly less in the VAC group (2.37, 2.43, and 1.60, respectively). The need for the secondary procedure, like flap or skin graft, was also the least in the VAC group, although insignificant. The mean hospital stay of the study subjects was 31.17 days, 24.13 days, and 15.17 days in the 3 groups, respectively. The mean cost of the treatment was 3076.67 INR, 3717.33 INR, and 10,680 INR, respectively. Conclusion:VAC dressing is the best option amongst the available dressing modalities in terms of faster healing and a short hospital stay. Foam dressing does provide an economically viable option with better results than conventional dressing.
C1 [Yadav, Amit Kumar; Panchal, Sameer] SIR HN Reliance Fdn Hosp & Res Ctr, Mumbai, India.
   [Mishra, Shaswat; Modi, Nihar; Amin, Stavan] Grant Govt Med Coll & Sir JJ Grp Hosp, Mumbai, India.
   [Khanna, Vikram] Ranjana Hosp, Allahabad, India.
RP Mishra, S (通讯作者)，Grant Govt Med Coll & Sir JJ Grp Hosp, Mumbai, India.
EM amit_aur09@yahoo.com; shaswatmishra1994@gmail.com; 86.khanna@gmail.com;
   panchalsameer1992@gmail.com; modi.nihar95@gmail.com;
   stavan120596@gmail.com
RI yadav, amit/ADR-1115-2022; Amin, Stavan/JAA-9909-2023
OI MISHRA, SHASWAT/0000-0003-4863-462X
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   BLACKMAN JD, 1994, DIABETES CARE, V17, P322, DOI 10.2337/diacare.17.4.322
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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   Etoz A, 2007, WOUNDS, V19, P250
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NR 24
TC 11
Z9 14
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD OCT
PY 2023
VL 43
IS 5
BP 647
EP 653
DI 10.1007/s13410-022-01163-3
EA JAN 2023
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S8IM4
UT WOS:000907751300001
PM 36619905
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Pan, T
   Li, K
   Fan, FD
   Gao, YS
   Wang, DJ
AF Pan, Tuo
   Li, Kai
   Fan, Fu-Dong
   Gao, Yong-Shun
   Wang, Dong-Jin
TI Vacuum-assisted closure vs. bilateral pectoralis major muscle
   flaps for deep sternal wounds infection
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Deep sternal wound infection (DSWI); vacuum-assisted closure therapy;
   bilateral pectoralis major muscle flaps (BPMMFs)
ID RISK-FACTORS; STERNOTOMY; THERAPY; MEDIASTINITIS; MANAGEMENT;
   RECONSTRUCTION; COMPLICATIONS
AB Background: Deep sternal wound infection (DSWI) is a life-threatening complication after cardiac surgery. The aim of this study was to retrospectively evaluate the outcomes of reconstructing infected poststernotomy wounds with either vacuum-assisted closure (VAC) after previous debridement or bilateral pectoralis major muscle flaps (BPMMFs).
   Methods: In total, 565 patients with postoperative DSWI were enrolled in this study from January 1, 2014, to June 1, 2018. Of these patients, 247 received BPMMFs. To address the indicated biases, a 1:1 propensity score-matched cohort was created based on age, body mass index, preoperative diabetes mellitus, chronic obstructive pulmonary disease (COPD), internal thoracic artery grafting (ITAG), type of cardiac surgery, time before treatment for DSWI and wound classification. After matching, 132 patients who had similar risk profiles were enrolled in the study population (66 in the VAC group: 66 in the BPMMF group).
   Results: At 21.9 +/- 12.1 (median: 24, IQR: 14-28) months of follow-up, the survival rate was 93.9% in the BPMMF group and 74.4% in the VAC group (P<0.01). Compared with the VAC group, the BPMMF group had a significantly decreased length of hospital stay (P<0.01). At the spirometry assessment, the forced expiratory volume in the 1st second (FEV1), vital capacity (VC), and FEV1/VC ratio showed no significant differences in survival between the VAC group and BPMMF group.
   Conclusions: In our study, compared with VAC therapy, BPMMFs guaranteed better early- and late-term outcomes, as shown by less length of hospital stay, a higher rate of long-term survival and unimpaired respiratory function.
C1 [Pan, Tuo; Li, Kai; Fan, Fu-Dong; Wang, Dong-Jin] Nanjing Univ, Affiliated Hosp, Med Sch, Nanjing Drum Tower Hosp,Dept Cardiothorac Surg, Nanjing 210008, Peoples R China.
   [Gao, Yong-Shun] Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Cardiovasc Surg, 5 Nanmencang, Beijing 100010, Peoples R China.
C3 Nanjing University; Chinese People's Liberation Army General Hospital
RP Gao, YS (通讯作者)，Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Cardiovasc Surg, 5 Nanmencang, Beijing 100010, Peoples R China.; Wang, DJ (通讯作者)，Nanjing Drum Tower Hosp, Dept Cardiothorac Surg, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
EM Yongshun_Gao@126.com; dongjin_wang@126.com
OI , Kai/0009-0006-4764-5430
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   Yu AW, 2013, INTERACT CARDIOV TH, V17, P861, DOI 10.1093/icvts/ivt326
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   Zhang ZH, 2017, ANN TRANSL MED, V5, DOI 10.21037/atm.2016.08.57
NR 27
TC 8
Z9 11
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD MAR
PY 2020
VL 12
IS 3
BP 866
EP 875
DI 10.21037/jtd.2019.12.76
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KX2UJ
UT WOS:000521736500083
PM 32274154
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hayashi, A
   Komoto, M
   Tanaka, R
   Natori, Y
   Matsumura, T
   Horiguchi, M
   Matsuda, N
   Yoshizawa, H
   Mizuno, H
AF Hayashi, Ayato
   Komoto, Masakazu
   Tanaka, Rica
   Natori, Yuhei
   Matsumura, Takashi
   Horiguchi, Masatoshi
   Matsuda, Norifumi
   Yoshizawa, Hidekazu
   Mizuno, Hiroshi
TI The availability of perifascial areolar tissue graft for deep cutaneous
   ulcer coverage
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Perifascial areolar tissue; Vacuum-assisted closure; Ulcer; Bone
   exposure; Tendon exposure; Deep cutaneous ulcer
ID VACUUM-ASSISTED-CLOSURE; ARTIFICIAL DERMIS; EXPOSED BONE; WOUNDS;
   SURGERY; DEFECTS
AB Soft tissue defects or skin ulcers associated with tendon or bone exposure located distally on the extremities are always difficult to treat. The introduction of the vacuum-assisted closure (VAC) and dermal templates has led to major changes in ulcer treatment strategies. However, it is necessary to find an alternative method to treat these defects when VAC is not available.
   Perifascial areolar tissue (PAT) is the loose connective tissue on the deep fascia that could be a candidate for repairing soft tissue defects or skin ulcers. Grafting PAT on the exposed bone or tendon, including a wide coverage of well-vascularized tissue surrounding the granulation tissue, can prepare the wound to be subsequently closed by a skin graft.
   In this study, the PAT was used in various situations and its optimal usage and outcomes were evaluated. A total of 13 PAT grafts were performed and were especially useful for covering narrow ulcers with narrow tendon exposure and filling fistula areas. In comparison to other cases, covering the exposed cortical bone ulcers seemed to be more difficult to perform. However, an option for these ulcers could be the exposure of bone marrow and usage of intraosseous blood flow. It was also possible for the simultaneous engraftment of PAT and skin in narrow areas and could be an alternative in cases of small concave ulcers or fistulae. The PAT graft is a simple and minimally invasive procedure that can be a good alternative when VAC is not available. (C) 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Hayashi, Ayato; Tanaka, Rica; Horiguchi, Masatoshi; Matsuda, Norifumi; Yoshizawa, Hidekazu; Mizuno, Hiroshi] Juntendo Univ, Sch Med, Dept Plast & Reconstruct Surg, Tokyo 1138421, Japan.
   [Komoto, Masakazu; Matsumura, Takashi] Juntendo Univ, Dept Plast & Reconstruct Surg, Sizuoka Hosp, Shizuoka, Japan.
   [Natori, Yuhei] Kawasakinanbu Hosp, Dept Plast & Reconstruct Surg, Kawasaki, Kanagawa, Japan.
C3 Juntendo University; Juntendo University
RP Hayashi, A (通讯作者)，Juntendo Univ, Sch Med, Dept Plast & Reconstruct Surg, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM ayhayasi@juntendo.ac.jp
FU Grants-in-Aid for Scientific Research [26713051] Funding Source: KAKEN
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brandi C, 2008, J PLAST RECONSTR AES, V61, P1507, DOI 10.1016/j.bjps.2007.09.036
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Eo S, 2011, INT WOUND J, V8, P261, DOI 10.1111/j.1742-481X.2011.00780.x
   Hachiya A, 2010, ANN OTO RHINOL LARYN, V119, P707, DOI 10.1177/000348941011901011
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 16
TC 13
Z9 17
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2015
VL 68
IS 12
BP 1743
EP 1749
DI 10.1016/j.bjps.2015.08.008
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CX7OA
UT WOS:000365890300025
PM 26354999
DA 2026-07-24
ER

PT J
AU Powers, AK
   Neal, MT
   Argenta, LC
   Wilson, JA
   DeFranzo, AJ
   Tatter, SB
AF Powers, Alexander K.
   Neal, Matthew T.
   Argenta, Louis C.
   Wilson, John A.
   DeFranzo, Anthony J.
   Tatter, Stephen B.
TI Vacuum-assisted closure for complex cranial wounds involving the loss of
   dura mater
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE complex scalp wound; vacuum-assisted closure; surgical technique
ID RANDOMIZED CONTROLLED-TRIAL; SUBATMOSPHERIC PRESSURE; RECONSTRUCTIVE
   SURGERY; NECK RECONSTRUCTION; SKIN-GRAFTS; THERAPY; MANAGEMENT; SYSTEM;
   HEAD; INTEGRA
AB The aim in this study was to describe the safety and efficacy of vacuum-assisted closure (VAC) in patients with complex cranial wounds with extensive scalp, bone, and dural defects who were not candidates for immediate free tissue transfer. Five patients (4 men and 1 woman) ages 24-73 years with complex cranial wounds were treated with VAC at Wake Forest Baptist Medical Center. Etiologies included trauma, squamous cell carcinoma, and malignant meningioma. Cutaneous wound defects measured as large as 15 cm in diameter. Four of the 5 patients had open skull defects with concomitant dural defects, and 1 patient had dural dehiscence. After surgical debridement, all 5 patients were treated with the direct application of a VAC device to a reapproximated dura mater (1 patient), to a pericranial flap (1 patient), or to a regenerative tissue matrix overlying CNS tissue (3 patients). In all cases involving open cranial wounds, the VAC device promoted granulation tissue formation over the dural substitute, prevented CSF leakage, and kept the wounds free from local infection. The duration of VAC therapy ranged from 16 to 91 days. Although VAC therapy was intended as a temporary measure until these patients could be stabilized for larger tissue transfer procedures or they succumbed to their primary pathology, 1 patient had a successful skin graft following VAC therapy. Hydrocephalus requiring shunt placement developed in 2 patients during VAC therapy. The VAC dressings applied to a tissue matrix or other barrier over brain tissue in extensive cranial wounds are safe and well tolerated, providing a functional barrier and preventing infection. (http://thejns.org/doi/abs/10.3171/2012.10.JNS112241)
C1 [Powers, Alexander K.; Neal, Matthew T.; Wilson, John A.; Tatter, Stephen B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurosurg, Winston Salem, NC 27157 USA.
   [Argenta, Louis C.; DeFranzo, Anthony J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP Powers, AK (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Neurosurg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM apowers@wfubmc.edu
RI Tatter, Stephen/AAD-6524-2021
OI Tatter, Stephen/0000-0002-1063-0431
FU KCI
FX Wake Forest University has patents pertaining to the VAC device and
   receives royalties from KCI for the device. Dr. Argenta receives a
   portion of these royalties by university policy.
CR Afifi AM, 2010, J CRANIOFAC SURG, V21, P1205, DOI 10.1097/SCS.0b013e3181e17c1e
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   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
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   Stiefel D, 2009, J PEDIATR SURG, V44, P575, DOI 10.1016/j.jpedsurg.2008.07.006
   Subotic U, 2011, NEUROSURGERY, V68, pE1481, DOI 10.1227/NEU.0b013e318210c7fb
   Tanna N, 2009, PLAST RECONSTR SURG, V123, p19E, DOI 10.1097/PRS.0b013e318194d215
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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   Yuan-Innes M J, 2001, Spine (Phila Pa 1976), V26, pE30
NR 44
TC 23
Z9 30
U1 0
U2 8
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 0022-3085
J9 J NEUROSURG
JI J. Neurosurg.
PD FEB
PY 2013
VL 118
IS 2
BP 302
EP 308
DI 10.3171/2012.10.JNS112241
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 076DY
UT WOS:000313937900012
PM 23157181
DA 2026-07-24
ER

PT J
AU Wang, Q
   Zhang, X
   Sun, WT
   Li, H
AF Wang, Quan
   Zhang, Xu
   Sun, Wentao
   Li, Hua
TI Clinical study on vacuum assisted closure combined with multiple flaps
   in the treatment of severe hand trauma
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Flap treatment; Vacuum assisted closure; Severe hand trauma; Survival
   rate
ID TISSUE; THERAPY
AB Objectives: To investigate the effect and clinical value of the application of vacuum assisted closure (VAC) combined with multiple flaps in the treatment of severe hand trauma. Methods: A total of 100 patients with severe hand trauma admitted to Harrison International Peace Hospital from September 2015 to September 2020 were selected and randomly divided into two groups according to the randomized block method: the single flap repair group and the combined repair group, with 50 patients in each group. Patients in the single flap repair group underwent flap repair according to their condition, while those in the combined repair group were treated with VAC prior to flap repair. The range of motion and hand sensation scores were compared between the two groups, and their levels of interleukin-8 (IL-8), tumor necrosis factor (TNF) and lipopolysaccharide (LPS) were tested by enzyme-linked immunosorbent assay (ELIS). Moreover, the flap survival rate and the incidence of adverse events were recorded and compared between the two groups. Results: Compared with the single flap repair group, the combined repair group had higher range of motion and hand sensation score (p<0.05), lower levels of IL-8, TNF and LPS (p<0.05), higher flap survival rate (p<0.05), and lower incidence of adverse events (p<0.05). Conclusion: VAC combined with multiple flaps boasts significant trauma repair effect and preferable clinical application value in the treatment of patients with severe hand trauma, which is principally reflected in significantly improving the hand function of patients and remarkably alleviating the inflammatory response of patients.
C1 [Zhang, Xu] Orthoped Hosp Sichuan Prov, Dept Orthoped, Chengdu 610041, Sichuan, Peoples R China.
   [Wang, Quan; Sun, Wentao; Li, Hua] Harrison Int Peace Hosp, Dept Hand & Foot Surg, Hengshui 053000, Hebei, Peoples R China.
RP Wang, Q (通讯作者)，Harrison Int Peace Hosp, Dept Hand & Foot Surg, Hengshui 053000, Hebei, Peoples R China.
EM has_rm_hyszwk@126.com
FU Hebei Medical Science Research Project [2019774]
FX The study was sponsored by Hebei Medical Science Research Project
   (No.2019774).
CR Cai Jieyun, 2018, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V32, P484, DOI 10.7507/1002-1892.201711135
   Cakmak MA, 2018, J CRANIOFAC SURG, V29, P735, DOI 10.1097/SCS.0000000000004331
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NR 23
TC 4
Z9 9
U1 0
U2 5
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2022
VL 38
IS 1
BP 248
EP 253
DI 10.12669/pjms.38.1.4631
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YL4AY
UT WOS:000745836400043
PM 35035434
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Denzinger, S
   Lübke, L
   Roessler, W
   Wieland, WF
   Kessler, S
   Burger, M
AF Denzinger, Stefan
   Luebke, Lars
   Roessler, Wolfgang
   Wieland, Wolf F.
   Kessler, Sigurd
   Burger, Maximilian
TI Vacuum-assisted closure versus conventional wound care in the treatment
   of wound failures following inguinal lymphadenectomy for penile cancer::
   A retrospective study
SO EUROPEAN UROLOGY
LA English
DT Article
DE inguinal lymphadenectomy; penile cancer; vacuum-assisted closure; wound
   failure
ID SQUAMOUS-CELL CARCINOMA; SENTINEL NODE BIOPSY; SUBATMOSPHERIC PRESSURE;
   GROIN; COMPLICATIONS
AB Objectives: Impaired wound healing is a frequent event in inguinal surgery and very common after lymphadenectomy for penile cancer. Although vacuum therapy has been reported to expedite the healing of complex wound failures, vacuum-assisted closure (VAC) has been reported to be contraindicated in malignancy. In the present study we evaluated the use of VAC in the treatment of complex wound failures following inguinal lymphadenectomy for penile cancer in comparison to conventional wound care (CWC) implying debridement and saline-soaked gauze.
   Methods: We retrospectively identified six inguinal wounds following inguinal lymphadenectomy for penile cancer and subsequent use of VAC from 2003 to 2006 at our institution. Data on surgical interventions, complications, length of time required for closure, and outcome were compared to 10 inguinal defects treated with CWC between 2000 and 2003.
   Results: Wound volume was comparable for both groups. Wound breakdown occurred at a median of 7.4 d after inguinal lymphadenectomy and was treated by CWC for a mean of 69.8 d. In the VAC group, the median duration until complete closure was 38.9 d. Thus, VAC was shown to result in complete wound, healing in less time (p < 0.001). No local recurrence in the VAC group was noted despite positive lymph nodes.
   Conclusions: VAC therapy is effective in complex inguinal wound failures following lymphadenectorny for penile cancer and appears to be superior to CWC. VAC seems to offer adequate safety concerning local recurrence. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 Univ Regensburg, Dept Urol, D-93053 Regensburg, Germany.
   Univ Munich, Dept Surg, Munich, Germany.
C3 University of Regensburg; University of Munich
RP Burger, M (通讯作者)，Univ Regensburg, Caritas Krankenhaus St Josef, Urol Klin, Landshuterstr 65, D-93053 Regensburg, Germany.
EM maximilian.burger@klinik.uni-regensburg.de
CR Algaba F, 2002, EUR UROL, V42, P199, DOI 10.1016/S0302-2838(02)00308-1
   AlSalman MMS, 1997, INT SURG, V82, P60
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NR 24
TC 14
Z9 16
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD MAY
PY 2007
VL 51
IS 5
BP 1320
EP 1325
DI 10.1016/j.eururo.2006.12.027
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 161YP
UT WOS:000246053400027
PM 17207916
DA 2026-07-24
ER

PT J
AU Kakagia, D
   Karadimas, EJ
   Drosos, G
   Ververidis, A
   Trypsiannis, G
   Verettas, D
AF Kakagia, D.
   Karadimas, E. J.
   Drosos, G.
   Ververidis, A.
   Trypsiannis, G.
   Verettas, D.
TI Wound closure of leg fasciotomy: Comparison of vacuum-assisted closure
   versus shoelace technique. A randomised study
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Fasciotomy; Wound; Leg injury; Vacuum-assisted closure; Shoelace
   technique
ID DELAYED PRIMARY CLOSURE; ACUTE COMPARTMENT SYNDROME; VESSEL LOOP
   SHOELACE; DEVICE; TRAUMA
AB Background: Fasciotomies, though essential for the prevention and management of compartment syndromes, may increase morbidity and prolong hospitalisation. Two widely applied methods of delayed primary closure are compared in leg fasciotomy wounds.
   Patients and methods: Two groups, each of 25 patients with leg fasciotomies due to fractures and soft tissue injuries, who were randomly assigned to be treated either by vacuum assisted closure (VAC (R), n = 42 wounds, group V) or by the shoelace technique (n = 40 wounds, group S), were evaluated in this study. Wound length, time to definite closure, complications, need for additional interventions and daily treatment costs were data collected and statistically assessed.
   Results: Wound closure time was significantly higher in group V compared to group S (p = 0.001; 95% CI of the difference, 1.8-6.3 days).
   Five group V patients required split thickness skin grafts. In six group S patients, the vessel loops had to be replaced.
   The mean daily cost of negative pressure therapy alone was 135 euro (range 117-144 euro), whilst the mean daily cost of treatment for the shoelace technique was 14 euro ranging from 8 to 18 euro (p = <0.001).
   Conclusions: Both VAC (R) and the shoelace technique are safe, reliable and effective methods for closure of leg fasciotomy wounds. VAC (R) requires longer time to definite wound closure and is far more expensive than the shoelace technique, especially when additional skin grafting is required. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kakagia, D.] Democritus Univ Thrace Hosp, Dept Plast & Reconstruct Surg, Alexandroupolis, Greece.
   [Karadimas, E. J.; Drosos, G.; Ververidis, A.; Verettas, D.] Democritus Univ Thrace Hosp, Dept Orthoped, Alexandroupolis, Greece.
   [Karadimas, E. J.] Hellen Red Cross Hosp, Dept Orthoped, Athens, Greece.
   [Trypsiannis, G.] Democritus Univ Thrace, Dept Med Stat, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace
RP Kakagia, D (通讯作者)，7 P Kirillou Str, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
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NR 28
TC 57
Z9 77
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2014
VL 45
IS 5
BP 890
EP 893
DI 10.1016/j.injury.2012.02.002
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA AD2AS
UT WOS:000333035500015
PM 22377275
DA 2026-07-24
ER

PT J
AU Dezfuli, B
   Li, CS
   Young, JN
   Wong, MS
AF Dezfuli, Bobby
   Li, Chin-Shang
   Young, J. Nilas
   Wong, Michael S.
TI Treatment of Sternal Wound Infection with Vacuum-Assisted Closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID RISK-FACTORS; MEDIAN STERNOTOMY; MEDIASTINITIS; COMPLICATIONS;
   MANAGEMENT; SURGERY; THERAPY; SURVIVAL; BRIDGE; IMPACT
AB Introduction. Previous work has demonstrated the efficacy of vacuum-assisted closure (VAC) in the treatment of poststernotomy local wound infections, compared to historical treatment protocol. The negative pressure has been found to protect wounds against contamination, prevent wound fluid retention, increase blood flow, and increase rates of granulation tissue formation. For this study, a retrospective analysis compared patients receiving VAC as definitive treatment versus bridging to delayed flap closure. Methods. Sixteen patients developed sternal wound infections after cardiac surgeries at the authors' institution from 2006 to 2008. Data was gathered regarding patient comorbidities, treatment method, and outcome. Study objectives included assessment of risk factors that warranted secondary surgical closure and examination of long-term followup where VAC was the definitive treatment modality. Results. Group A (n = 12) had VAC as the final treatment modality. Group B (n = 4) required myocutaneous flap closure. One patient in Group B passed away prior to flap surgery. Both groups had similar risk factors, except Group B had a higher risk of body mass index (BMI) > 35 that was near statistically significant (P = 0.085; odds ratio = 0.0, 95% CI = [0.0 - 1.21]). Group A required a shorter hospital stay on average. Long-term follow-up showed the majority of Group A had completely healed sternal wounds 2-3 years from initial cardiac surgery. Conclusions. Vacuum-assisted closure as definitive treatment modality is a successful, first line therapy for local superficial sternal wound infections. When deep infections occur, however, VAC as bridge-to-flap coverage is recommended over attempted secondary healing with VAC.
C1 [Dezfuli, Bobby] Univ Arizona, Med Ctr, Dept Orthopaed Surg, Tucson, AZ 85719 USA.
   [Li, Chin-Shang] Univ Calif Davis, Dept Publ Hlth Sci, Div Biostat, Davis, CA 95616 USA.
   [Young, J. Nilas] UC Davis Sch Med, Dept Surg, Div Cardiothorac Surg, Sacramento, CA USA.
   [Wong, Michael S.] UC Davis Sch Med, Dept Surg, Div Plast & Reconstruct Surg, Sacramento, CA USA.
C3 University of Arizona; University of California System; University of
   California Davis; University of California System; University of
   California Davis; University of California System; University of
   California Davis
RP Dezfuli, B (通讯作者)，Univ Arizona, Med Ctr, Dept Orthopaed Surg, 1609 N Warren Ave,Suite 110,POB 245064, Tucson, AZ 85719 USA.
EM dezfuli@email.arizona.edu
FU National Center for Research Resources, a component of the National
   Institutes of Health [UL1 RR024146]; NIH Roadmap for Medical Research
FX The authors would like to acknowledge the Division of Cardiothoracic
   Surgery and Keanna Jordan from the Health Information Management
   Department at UCDMC for their help with data collection. This
   publication was made possible by Grant Number UL1 RR024146 from the
   National Center for Research Resources, a component of the National
   Institutes of Health and NIH Roadmap for Medical Research.
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NR 38
TC 1
Z9 1
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2013
VL 25
IS 2
BP 41
EP 50
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 096UM
UT WOS:000315430100005
PM 25867806
DA 2026-07-24
ER

PT J
AU Parcells, AL
   Abernathie, B
   Datiashvili, R
AF Parcells, Alexis Lanteri
   Abernathie, Brenon
   Datiashvili, Ramazi
TI The Use of Urinary Bladder Matrix in the Treatment of Complicated Open
   Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE urinary bladder matrix; complicated wounds; vacuum-assisted closure
ID SMALL-INTESTINAL SUBMUCOSA; SOFT-TISSUE REPAIR; EXTRACELLULAR-MATRIX;
   DOG-MODEL; SCAFFOLDS; DEGRADATION; THERAPY; REGENERATION; BIOSCAFFOLD
AB Background. Management of complicated open wounds represents a challenge when reconstructive options are not applicable. Urinary bladder matrix (UBM) provides a biocompatible material that allows inductive tissue remodeling. Methods. The use of urinary bladder matrix in the treatment of 5 patients with complicated open wounds that failed to heal with conventional therapy is presented. Results. A 3-year old male sustained a second-degree oil burn measuring 8 cm x 4 cm to his dorsal forearm; UBM was applied weekly and the wound epithelialized in 3 weeks. A 52-year old male sustained massive second and third degree burns to his leg after a fire; UBM was applied weekly and the wound epithelialized in 28 weeks. A 61-year old female sustained a severe crushing injury to her right knee. A gastrocnemius muscle transfer and rectus abdominus muscle free flap transfer both failed, then UBM and vacuum-assisted closure therapy were applied and the wound epithelialized in 24 weeks. A 54-year old,female underwent a breast mastectomy and immediate reconstruction with pedicled transverse rectus abdominus flap. The patient developed partial necrosis and the wound was managed with UBM and vacuum-assisted closure therapy. The wound epithelialized in 12 weeks. A 36-year old female sustained severe degloving injuries to both hands with exposed metacarpals. Weekly application of UBM provided tissue remodeling over the bones, which allowed successful skin grafting and closure. Conclusions. These experiences show UBM to be an effective method in management of complicated open wounds in select cases. Further studies need to be implemented to confirm this conclusion.
C1 [Parcells, Alexis Lanteri; Abernathie, Brenon; Datiashvili, Ramazi] Rutgers Biomed & Hlth Sci, Dept Surg, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Parcells, AL (通讯作者)，Rutgers Biomed & Hlth Sci, Dept Surg, Div Plast Surg, 140 East Bergen St Suite 1620, Newark, NJ 07103 USA.
EM lanteral@njms.rutgers.edu
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NR 24
TC 30
Z9 31
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2014
VL 26
IS 7
BP 189
EP 196
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AM0NA
UT WOS:000339541100002
PM 25860538
DA 2026-07-24
ER

PT J
AU Brox-Jiménez, A
   Díaz-Gómez, D
   Parra-Membrives, P
   Martínez-Baena, D
   Márquez-Muñoz, M
   Lorente-Herce, J
   Jiménez-Vega, J
AF Brox-Jimenez, Antonia
   Diaz-Gomez, Daniel
   Parra-Membrives, Pablo
   Martinez-Baena, Dario
   Marquez-Munoz, Macarena
   Lorente-Herce, Jose
   Jimenez-Vega, Javier
TI A vacuum assisted closure system in complex wounds: a retrospective
   study
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Vacuum-assisted closure (VAC therapy); Complex wounds; Therapy
ID OPEN ABDOMEN; THERAPY
AB Introduction: Vacuum-assisted closure (VAC) therapy is a dynamic and non-invasive system for improving wound healing. This novel therapy is based on applying air suction at a controlled sub-atmospheric pressure. The most important benefits of this therapy include, a reduction in the wound area together with induction of new granulation tissue formation, effective wound cleansing (removal of small tissue by suction), and the continuous removal of wound exudate.
   The aim of this study was to describe our experience with VAC therapy for complex wounds.
   Material and method: We retrospectively evaluated our experience with VAC therapy between April 2007 and August 2008. We employed a "suprafascial" VAC system and an open abdomen VAC system. Descriptive statistical techniques were applied and percentages and means were calculated.
   Results: VAC therapy was applied in 20 patients, of whom 16(80%) had abdominal complex wounds, and 4(20%) in other locations. We employed a "suprafascial" VAC system in 17 patients (85%) and an "intra-abdominal" VAC system in 3 patients (15%). Two patients (10%) developed fistula during "intra-abdominal" VAC therapy (urinary and enteric) but the closure was achieved before therapy was finished. Mean hospital stay was 38.3 days (7-136). No mortality was directly due to the VAC system. Two patients (10%) died due to their septic condition and the rest are still alive. Mean therapy length was 29.17 days (1-77) in the "suprafascial" group and 18 days (7-49) in the "intra-abdominal" group. Average costs were 3197.97 (sic) (119.1-10780.25) per patient.
   Conclusions: VAC therapy can improve and accelerate abdominal wound healing also in the presence of infection and bowel fistula. (C) 2009 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Brox-Jimenez, Antonia] Complejo Hosp Pontevedra, Serv Cirugia Gen & Aparato Digest, Pontevedra, Spain.
   [Diaz-Gomez, Daniel; Parra-Membrives, Pablo; Martinez-Baena, Dario; Marquez-Munoz, Macarena; Lorente-Herce, Jose; Jimenez-Vega, Javier] Hosp Univ Valme, Serv Cirugia Gen & Aparato Digest, Seville, Spain.
C3 Complexo Hospitalario Universitario de Pontevedra; Hospital Valme
RP Brox-Jiménez, A (通讯作者)，Complejo Hosp Pontevedra, Serv Cirugia Gen & Aparato Digest, Pontevedra, Spain.
EM broxji@yahoo.es
RI ; Parra Membrives, Pablo/A-8851-2019; Martínez-Baena,
   Darío/HHC-3406-2022
OI Lorente-Herce, José Manuel/0000-0002-0579-6306; Parra Membrives,
   Pablo/0000-0002-5044-4828; 
CR Arigon JP, 2008, J CHIR-PARIS, V145, P252, DOI 10.1016/S0021-7697(08)73755-4
   Brox-Jimenez Antonia, 2007, Cir Esp, V82, P150
   de Costa A, 2006, ANZ J SURG, V76, P356, DOI 10.1111/j.1445-2197.2006.03638.x
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NR 9
TC 13
Z9 22
U1 0
U2 10
PU ELSEVIER DOYMA SL
PI BARCELONA
PA TRAVESERA DE GARCIA, 17-21, BARCELONA, 08021, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD MAY
PY 2010
VL 87
IS 5
BP 312
EP 317
DI 10.1016/j.ciresp.2010.02.001
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 596FC
UT WOS:000277669300008
PM 20378103
DA 2026-07-24
ER

PT J
AU Risnes, I
   Abdelnoor, M
   Veel, T
   Svennevig, JL
   Lundblad, R
   Rynning, SE
AF Risnes, Ivar
   Abdelnoor, Michael
   Veel, Terje
   Svennevig, Jan Ludvig
   Lundblad, Runar
   Rynning, Stein Erik
TI Mediastinitis after coronary artery bypass grafting: the effect of
   vacuum-assisted closure versus traditional closed drainage on survival
   and re-infection rate
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Coronary artery bypass grafting; Mediastinitis; Mortality; Re-infection;
   Traditional closed drainage; Vacuum-assisted closure
ID LONG-TERM SURVIVAL; STERNAL WOUND-INFECTION; RISK-FACTORS;
   POSTSTERNOTOMY MEDIASTINITIS; THERAPY; IMPACT; MORTALITY; SURGERY
AB Mediastinitis is treated with either vacuum-assisted closure (VAC) or traditional closed drainage (TCD) with irrigation. The aim of the study was to determine the effect of the two treatments on mortality and re-infection rate in a source population, using 21 314 consecutive patients undergoing isolated coronary artery bypass grafting (CABG) from January 1997 to October 2010. Median observation time was 2.9 years in the VAC group and 8.0 years in the TCD group. The epidemiological design was of an exposed (VAC, n = 64) versus non-exposed (TCD, n = 66) cohort with two endpoints: (1) mortality and (2) failure of sternal wound healing or re-infection. The crude effect of treatment technique versus endpoint was estimated by univariate analysis. Stratification analysis by the Mantel-Haenszel method was performed to quantify confounders and to pinpoint effect modifiers. Adjustment for confounders was performed using Cox regression analysis. Mediastinitis was diagnosed 6-105 (median 14) days after primary operation in the VAC group and 13 (5-29) days in the TCD group. There was no difference between groups in long-term survival. Failure of sternal wound healing or re-infection occurred less frequently in the VAC group (6%) than in the TCD group (21%; relative risk = 0.29, 95% CI = 0.06-0.88, P = 0.01). There are concerns for increase in right ventricle rupture in VAC compared with TCD. There was no difference in survival after VAC therapy and TCD therapy of post-CABG mediastinitis. Failure of sternal wound healing or re-infection was more common after TCD therapy.
C1 [Risnes, Ivar; Veel, Terje; Rynning, Stein Erik] Feiring Heart Clin, Feiring, Norway.
   [Abdelnoor, Michael] Oslo Univ Hosp, Unit Epidemiol & Biostat, Oslo, Norway.
   [Svennevig, Jan Ludvig; Lundblad, Runar] Oslo Univ Hosp, Dept Thorac & Cardiovasc Surg, Oslo, Norway.
C3 University of Oslo; University of Oslo
RP Risnes, I (通讯作者)，Feiring Heart Clin, Feiring, Norway.
EM ivar.risnes@feiringklinikken.no
RI abdelnoor, michael/K-4248-2019
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
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NR 24
TC 25
Z9 35
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 177
EP 182
DI 10.1111/j.1742-481X.2012.01060.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100011
PM 22925188
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Barysch, MJ
   Weibel, L
   Neuhaus, K
   Subotic, U
   Schärer, L
   Donghi, D
   Hafner, J
   Braun, R
   Läuchli, S
   Dummer, R
   Schiestl, C
AF Barysch, Marjam J.
   Weibel, Lisa
   Neuhaus, Kathrin
   Subotic, Ulrike
   Schaerer, Leo
   Donghi, Davide
   Hafner, Juerg
   Braun, Ralph
   Laeuchli, Severin
   Dummer, Reinhard
   Schiestl, Clemens
TI Dermatofibrosarcoma Protuberans in Childhood Treated with Slow Mohs
   Micrographic Surgery
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
ID IMATINIB MESYLATE; EXCISION; CHILDREN
AB Dermatofibrosarcoma protuberans (DFSP) in childhood is a rare tumor with high recurrence rates. Wide local excision can result in disfiguring mutilation, whereas Mohs micrographic surgery (MMS) reduces surgical margins. MMS in children is not performed routinely, as the required infrastructures such as a histopathology lab in close proximity to the operating room is often lacking. We retrospectively reviewed children diagnosed with DFSP treated at our hospital over 2years. We recorded surgical treatment details, including margins, duration of inpatient stay, outcome, follow-up, and molecular genetic tumor tissue analysis. Four children with a median age of 6.8years (range 6.0-8.8years) were identified who had a diagnostic delay of a median of 2.5years (range 0.5-4.0years); all underwent complete tumor excision using the slow MMS technique using vacuum-assisted closure systems between repeated excisions and before wound closure. The median maximal safety margins were 1.5cm (range 1.0-3.0cm). By using vacuum-assisted closure systems, no dressing changes were needed, pain was limited, and full mobility was maintained in all children. The median total time in the hospital was 11days (range 10-14days). No relapses occurred during a median follow-up of 25.8months (range 11.3-32.6months). Collagen 1A1/platelet-derived growth factor B (COL1A1/PDGFB) translocation on chromosomes 17 and 22 was detected in all three analyzable specimens. Lesions suspected of being DFSP warrant prompt histologic evaluation; interdisciplinary management is mandatory in particular for children. Micrographic surgery allows smaller surgical margins than wide excision and should be considered as the treatment of choice in children with DFSP. The interim usage of vacuum-assisted closure systems increases patient comfort. Translocations in the COL1A1/PDGFB gene imply susceptibility to targeted treatment modalities for therapy-resistant cases.
C1 [Barysch, Marjam J.; Neuhaus, Kathrin; Subotic, Ulrike; Schiestl, Clemens] Univ Childrens Hosp Zurich, Dept Plast & Reconstruct Surg, Zurich, Switzerland.
   [Barysch, Marjam J.; Weibel, Lisa; Hafner, Juerg; Braun, Ralph; Laeuchli, Severin; Dummer, Reinhard] Univ Zurich Hosp, Dept Dermatol, CH-8091 Zurich, Switzerland.
   [Barysch, Marjam J.; Weibel, Lisa; Neuhaus, Kathrin; Subotic, Ulrike; Schiestl, Clemens] Childrens Res Ctr, Zurich, Switzerland.
   [Weibel, Lisa] Univ Childrens Hosp Zurich, Zurich, Switzerland.
   [Schaerer, Leo] Inst Dermatopathol, Friedrichshafen, Germany.
C3 University Children's Hospital Zurich; University of Zurich; University
   Zurich Hospital; University Children's Hospital Zurich
RP Schiestl, C (通讯作者)，Univ Childrens Hosp Zurich, Dept Surg, Zurich, Switzerland.
EM clemens.schiestl@kispi.uzh.ch
RI ; Dummer, Reinhard/JQI-5867-2023
OI Subotic, Ulrike/0000-0002-1383-1036; Braun, Ralph P/0000-0003-1253-8206;
   Weibel, Lisa/0000-0002-8696-8164; Neuhaus, Kathrin/0000-0003-2438-1779
CR Chang CK, 2004, EJSO, V30, P341, DOI 10.1016/j.ejso.2003.12.005
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NR 25
TC 12
Z9 15
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD JUL
PY 2013
VL 30
IS 4
BP 462
EP 468
DI 10.1111/pde.12039
PG 7
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA 175CC
UT WOS:000321206100024
PM 23432099
OA Bronze
DA 2026-07-24
ER

PT J
AU Dhir, K
   Reino, AJ
   Lipana, J
AF Dhir, Karan
   Reino, Anthony J.
   Lipana, Jon
TI Vacuum-Assisted Closure Therapy in the Management of Head and Neck
   Wounds
SO LARYNGOSCOPE
LA English
DT Article; Proceedings Paper
CT Eastern Section Meeting of the Triologic-Society
CY JAN 25-27, 2008
CL Philadelphia, PA
SP Triol Soc
DE Vacuum-assisted closure; wound VAC; wound dehiscence; salivary leak;
   chronic wound care
ID SECURING SKIN-GRAFTS; DEVICE; SOFT
AB Objectives: The wound vacuum-assisted closure (VAC) has been used in many areas of surgery to promote healing and facilitate secondary reconstruction. Until recently, this treatment modality was overlooked in the otolaryngology literature, and the authors propose that its use should be routine in the treatment of complex head and neck wounds.
   Study Design: An unbiased cohort study without conflict of interest at two tertiary care centers.
   Materials and Methods: All patients treated by the authors presented with complex head and neck wounds from 2005 to 2007 and were subjected to wound VAC therapy. The wound VAC dressing was changed every 72 hours, and the wound etiology, wound site, history of chemotherapy and radiation, hospital duration, gender, outcome, and ancillary procedures were recorded.
   Results: Nineteen patients with 33 wounds were treated using VAC therapy. Eighty-four percent of these patients healed completely without the need for further surgical intervention. The mean age of this cohort was 63.2 years, with a range of 48-75 years. Males far outnumbered females in this study (17:2). Outpatient therapy commenced at discharge after an average of 11.4 days following a hospital stay ranging between 5 and 28 days. Adjunctive procedures performed during and after VAC therapy included hyperbaric oxygen treatment, dermal grafts, salivary diversion, and regional flap reconstruction.
   Conclusions: This study shows the applicability and versatility of vacuum-assisted wound closure in the head and neck. Based on our results the authors feel that this mode of therapy should be a routine part of the Otolaryngologist's armamentarium for the treatment of complex and refractory head and neck wounds.
C1 [Dhir, Karan; Reino, Anthony J.; Lipana, Jon] Mt Sinai Sch Med, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Reino, AJ (通讯作者)，Mt Sinai Sch Med, Dept Otolaryngol Head & Neck Surg, 1 Gustave L Levy Pl,Box 1189, New York, NY 10029 USA.
EM areino@optionline.net
CR [Anonymous], 2004, WOUNDS, p3S
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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NR 28
TC 48
Z9 56
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD JAN
PY 2009
VL 119
IS 1
BP 54
EP 61
DI 10.1002/lary.20000
PG 8
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine; Otorhinolaryngology
GA 396EO
UT WOS:000262575200010
PM 19117292
DA 2026-07-24
ER

PT J
AU Fahrenkrog, C
   Miftode, S
   Al-Mawsheki, A
   Alfarawan, F
   Wilters, S
   Bockhorn, M
   El-Sourani, N
AF Fahrenkrog, Catharina
   Miftode, Sorin
   Al-Mawsheki, Ahmed
   Alfarawan, Fadl
   Wilters, Stella
   Bockhorn, Maximilian
   El-Sourani, Nader
TI Effect of Neoadjuvant Therapy on Endoluminal Vacuum-Assisted Closure
   Therapy (EVAC) for Anastomotic Leakage After Oesophagectomy
SO CANCERS
LA English
DT Article
DE endoluminal vacuum-assisted closure; EVAC; anastomotic leakage;
   oesophagectomy; neoadjuvant therapy; chemotherapy; chemoradiation;
   oesophageal cancer
ID SQUAMOUS-CELL CARCINOMA; COMPLICATIONS; CHEMORADIOTHERAPY; RADIATION;
   CHEMORADIATION; ADENOCARCINOMA; MORTALITY; PROGRAM; SURGERY; RISK
AB Background: Anastomotic leakage (AL) is a dreaded complication after oesophagectomy. Endoluminal vacuum-assisted closure therapy (EVAC) has been increasingly used as a first-line treatment for AL. We aimed to identify any potential adverse effects of a neoadjuvant therapy (chemotherapy (CT) or radiochemotherapy (RCT)) on EVAC. Methods: We performed a retrospective cohort study at our tertiary centre between 2013 and 2024. All patients who underwent EVAC for AL after oesophagectomy were included in this study. Parameters such as success rate, length of therapy, number of sponges needed, changes in treatment, and survival were analysed. Results: A total of 29 patients were included, 19 of whom received CT/RCT and 10 of whom received no neoadjuvant treatment (NT). There was no significant difference in patient survival (30-day survival rate CT/RCT n = 1 (5.3%) vs. NT n = 1 (10%), p = 0.632), success rate (CT/RCT n = 15 (78.9%) vs. NT n = 9 (90%), p = 0.454), and length of therapy (CT/RCT vs. NT 24.11 vs. 23.8, p = 0.681), the number of sponges required (CT/RCT vs. NT 6.26 vs. 6.6, p = 0.835), and the need for changing treatment (CT/RCT n = 5 (26.3%) vs. NT n = 1 (10%), p = 0.303). Conclusions: NT did not affect the success rate or length of therapy. Thus, we found no significant influence of CT/RCT on EVAC for AL after oesophagectomy.
C1 [Fahrenkrog, Catharina; Wilters, Stella; Bockhorn, Maximilian; El-Sourani, Nader] Carl von Ossietzky Univ Oldenburg, Univ Med Oldenburg, D-26129 Oldenburg, Germany.
   [Miftode, Sorin; Al-Mawsheki, Ahmed; Alfarawan, Fadl; Bockhorn, Maximilian] Klinikum Oldenburg AoR, Univ Klin Allgemein & Viszeralchirurg, D-26133 Oldenburg, Germany.
   [El-Sourani, Nader] Univ Klinikum Munster, Klin Allgemein Viszeral & Transplantat Chirurg, D-48149 Munster, Germany.
C3 Carl von Ossietzky Universitat Oldenburg; Klinikum Oldenburg; University
   of Munster
RP El-Sourani, N (通讯作者)，Carl von Ossietzky Univ Oldenburg, Univ Med Oldenburg, D-26129 Oldenburg, Germany.; El-Sourani, N (通讯作者)，Univ Klinikum Munster, Klin Allgemein Viszeral & Transplantat Chirurg, D-48149 Munster, Germany.
EM nader.el-sourani@ukmuenster.de
RI El-Sourani, Nader/GRO-7989-2022; Alfarawan, Fadl/NZO-4372-2025
OI El-Sourani, Nader/0000-0002-6146-7785; Al-Mawsheki,
   Ahmed/0009-0002-2079-3135; 
CR Aktories Klaus., 2022, Allgemeine und spezielle Pharmakologie und Toxikologie. Lehrbuch und Nachschlagewerk fur Studierende der Medizin, Zahnmedizin, Pharmazie und Veterinarmedizin, fur Arzte, Zahnarzte
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NR 36
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV
PY 2024
VL 16
IS 21
AR 3597
DI 10.3390/cancers16213597
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA L5G3O
UT WOS:001350994600001
PM 39518039
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, TY
   Yan, Y
   Xie, XM
   Mu, WD
AF Zhang, Taiyuan
   Yan, Yan
   Xie, Xinmin
   Mu, Weidong
TI Minimally Invasive Sinus Tarsi Approach With Cannulated Screw Fixation
   Combined With Vacuum-Assisted Closure for Treatment of Severe Open
   Calcaneal Fractures With Medial Wounds
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Bohler's angle; calcaneus; injury; length of stay; negative pressure;
   open fracture
ID INTERNAL-FIXATION; INTRAARTICULAR FRACTURES; OPEN REDUCTION;
   COMPLICATIONS
AB The aim of our prospective study was to investigate the clinical results and advantages of a minimally invasive sinus tarsi approach with cannulated screw fixation combined with vacuum-assisted closure for the treatment of severe open calcaneal fractures with medial wounds. A total of 31 patients (32 feet) with open calcaneal fractures who were admitted to our hospital from January 2008 to May 2013 were selected for the study and randomly divided into 2 groups: the cannulated screw group (n = 16 patients, 16 feet) and the plate group (n = 15 patients, 16 feet). The Bohler and Gissane angles were compared before and after surgery. The clinical results were evaluated using according to the American Orthopaedic Foot and Ankle Society ankle-hindfoot scale and the rate of infection. The follow-up duration for all patients ranged from 10 to 36 (mean 24) months. No statistically significant differences were found in the radiologic indicators, incidence of early postoperative complications, or American Orthopaedic Foot and Ankle Society ankle-hindfoot scores (p > .05) between the 2 groups. However, a statistically significant difference was seen in the duration of hospitalization (p < .05) between the 2 groups. A minimally invasive sinus tarsi approach with cannulated screw fixation combined with vacuum-assisted closure is an effective method for the treatment of severe open calcaneal fractures with medial wounds. It provides good reduction and requires fewer days of hospitalization. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Zhang, Taiyuan; Mu, Weidong] Shandong Univ, Shandong Prov Hosp, Dept Traumat Orthopaed, Jinan 250021, Shandong, Peoples R China.
   [Zhang, Taiyuan; Xie, Xinmin] Third Peoples Hosp Jinan, Orthopaed Ctr, Jinan, Peoples R China.
   [Yan, Yan] Third Peoples Hosp Jinan, Dept Paediat, Jinan, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences
RP Mu, WD (通讯作者)，Shandong Univ, Shandong Prov Hosp, Dept Traumat Orthopaed, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
EM 13791035080@139.com
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NR 29
TC 9
Z9 12
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 112
EP 116
DI 10.1053/j.jfas.2015.07.023
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200025
PM 26372552
DA 2026-07-24
ER

PT J
AU Flandrin, A
   Rouleau, C
   Azar, C
   Dubon, O
   Ludovic, P
AF Flandrin, Anaig
   Rouleau, Caroline
   Azar, Chaible
   Dubon, Olivier
   Ludovic, Pierre
TI First Report of a Necrotising Fasciitis of the Breast Following a Core
   Needle Biopsy
SO BREAST JOURNAL
LA English
DT Article
DE breast; core needle biopsy; necrotising fasciitis; vacuum therapy
ID VACUUM-ASSISTED CLOSURE
AB Necrotising fasciitis (NF) is the most aggressive form of soft tissue infection. We report the first case of NF of the breast following a core needle biopsy. Aggressive management including surgical debridement and vacuum therapy allowed wound healing and breast conservation.
C1 [Flandrin, Anaig; Azar, Chaible; Dubon, Olivier; Ludovic, Pierre] Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, Oncol Unit, F-34295 Montpellier 5, France.
   [Rouleau, Caroline] Hop Lapeyronie, Dept Pathol, Montpellier 5, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Ludovic, P (通讯作者)，Hop Arnaud de Villeneuve, Dept Obstet & Gynecol, Oncol Unit, F-34295 Montpellier 5, France.
EM pl.giacalone@cegetel.net
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 17
TC 30
Z9 31
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1075-122X
EI 1524-4741
J9 BREAST J
JI Breast J.
PD MAR-APR
PY 2009
VL 15
IS 2
BP 199
EP 201
DI 10.1111/j.1524-4741.2009.00697.x
PG 3
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 417PG
UT WOS:000264087900013
PM 19292808
DA 2026-07-24
ER

PT J
AU Shields, LBE
   Chariker, M
   Sieg, EP
   Mutchnick, IS
AF Shields, Lisa B. E.
   Chariker, Mark
   Sieg, Emily P.
   Mutchnick, Ian S.
TI Vacuum-assisted closure of the scalp flap following malignant cerebral
   edema during craniotomy: pediatric case presentations and review of the
   literature
SO CHILDS NERVOUS SYSTEM
LA English
DT Article
DE Neurosurgery; Pediatric; Cerebral edema; Craniotomy; Vacuum-assisted
   closure
ID WOUND CONTROL; MANAGEMENT; THERAPY; HEAD; SYSTEM; BRAIN; SAFE
AB Intraoperative malignant cerebral edema is a rare but life-threatening complication that can arise during a traumatic decompressive craniectomy. The swelling may be significant enough to preclude skin closure. The current standard of care is to resect sufficient edematous brain tissue to close the scalp to establish an immune-competent barrier to the intracranial space. We report two pediatric patients who developed malignant edema during craniectomy that prevented skin closure. Both patients underwent placement of a temporary vacuum-assisted closure (VAC) device, facilitating resolution of the edema without sacrifice of brain tissue before scalp closure. Case #1 sustained a fall; head computed topography (CT) revealed a left subdural hematoma (SDH) and hemispheric infarct with midline shift. A craniotomy was performed during which malignant cerebral edema developed, preventing dural closure or scalp approximation. A VAC was placed which remained for 17 days, followed by successful primary closure of the scalp. Case #2 suffered multiple injuries from inflicted trauma; head CT demonstrated a large acute SDH over the left frontal and parietal region with a midline shift to the right. Emergent craniotomy was performed, and significant cranial edema was encountered to a degree for which medical intervention was not effective enough to allow skin closure. A VAC device was placed which was removed 8 days later with primary scalp closure. No infectious complications arose in either case, and no complications were attributable to the VAC devices. A temporizing VAC to protect the intracranial space when severe malignant cerebral edema occurs during a craniectomy may be preferable to tissue resection.
C1 [Shields, Lisa B. E.; Mutchnick, Ian S.] Norton Healthcare, Norton Neurosci Inst, 210 East Gray St, Suite 1102, Louisville, KY 40202 USA.
   [Chariker, Mark; Mutchnick, Ian S.] Norton Childrens Hosp, Louisville, KY 40202 USA.
   [Chariker, Mark] Kentucky Ctr Cosmet & Reconstruct Surg, Louisville, KY 40202 USA.
   [Sieg, Emily P.; Mutchnick, Ian S.] Univ Louisville, Hlth Brain & Spine Inst, Louisville, KY 40202 USA.
C3 University of Louisville
RP Mutchnick, IS (通讯作者)，Norton Healthcare, Norton Neurosci Inst, 210 East Gray St, Suite 1102, Louisville, KY 40202 USA.; Mutchnick, IS (通讯作者)，Norton Childrens Hosp, Louisville, KY 40202 USA.; Mutchnick, IS (通讯作者)，Univ Louisville, Hlth Brain & Spine Inst, Louisville, KY 40202 USA.
EM LBES@earthlink.net; drchariker@drchariker.com;
   Emily.Sieg@uoflhealth.org; ianmutchnick@gmail.com
OI Sieg, Emily/0009-0007-7945-197X
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD OCT 30
PY 2025
VL 41
IS 1
AR 338
DI 10.1007/s00381-025-07008-8
PG 8
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA 9FD3O
UT WOS:001604873000002
PM 41165862
DA 2026-07-24
ER

PT J
AU Sun, YW
   Li, L
   Zhang, ZH
AF Sun, Yan-Wei
   Li, Liang
   Zhang, Zhi-Hua
TI Antibiotic-loaded Bone Cement Combined with Vacuum-assisted Closure
   Facilitating Wound Healing in Wagner 3-4 Diabetic Foot Ulcers
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE antibiotic-loaded bone cement; diabetic foot ulcer; vacuum-assisted
   closure; wagner grade; wound
ID MANAGEMENT; THERAPY; PREVENTION
AB This study explored the clinical effectiveness of antibiotic-loaded bone cement (ALBC) combined with vacuum-assisted closure (VAC) on the treatment of Wagner 3-4 diabetic foot ulcers (DFUs). This is a retrospective study, including 32 patients with Wagner 3-4 DFUs who had undergone treatment between August 2019 and June 2021. Patient age, sex, Hemoglobin A1c (HbA1c), body mass index (BMI), ankle brachial index (ABI), white blood cells (WBC), C-reactive protein (CRP) levels, comorbidities and wound closure methods were recorded. Patients were divided into the study group and control group according to the treatment modality. Patients in the study group received the combination treatment of ALBC and VAC, while patients in the control group received single VAC treatment. Clinical endpoints were assessed and compared between the two groups, including wound complete healing time and complications after operation. All patients were followed-up 6 months postoperation. Results showed that the mean healing time of the study group (44.20 +/- 16.72 days) was shorter than that of the control group (64.00 +/- 29.85 days) (P < .05). The infection rate of the study group on the 10th day postoperation was lower than that of the control group (6.67%, 47.06%, P < .05). And there were no significant statistical differences between the two groups in terms of bleeding and necrosis complications postoperation (P = .603, P = .603). Based on the findings, we conclude that the application of ALBC combined with VAC can facilitate wound healing in Wagner 3-4 DFUs patients. It can help to control wound infections and shorten wound healing time.
C1 [Sun, Yan-Wei; Li, Liang] Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
   [Zhang, Zhi-Hua] Qingdao Univ, Dept Vasc Surg, Affiliated Qingdao Cent Hosp, Qingdao, Shandong, Peoples R China.
C3 Qingdao University
RP Sun, YW (通讯作者)，Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
EM syanwei005@163.com
RI sun, yanwei/LFS-0201-2024
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NR 28
TC 13
Z9 17
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2022 JUN 15
PY 2022
AR 15347346221109045
DI 10.1177/15347346221109045
EA JUN 2022
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 2F7VM
UT WOS:000813113700001
PM 35706401
DA 2026-07-24
ER

PT J
AU Stroder, M
   Litt, JS
   Litofsky, NS
AF Stroder, Madelyn
   Litt, Jeffrey S.
   Litofsky, N. Scott
TI Complex Multidisciplinary Cranial and Scalp Reconstruction for Patient
   Salvage
SO WORLD NEUROSURGERY
LA English
DT Article
DE Complex; Cranial; Dermal regeneration template; Multidisciplinary;
   Reconstruction; Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; WOUNDS; FLAP;
   MANAGEMENT; THERAPY; CALVARIA; HEAD; DURA; SKIN
AB OBJECTIVE/BACKGROUND: Patients can develop scalp and cranial defects as a result of neoplasm, trauma, or infection. Reconstruction of these defects can be difficult in some patients and may require a multidisciplinary approach using creative solutions usually used for disease processes in other areas of the body, such as severe burns. -METHODS: A series of 9 patients were treated using multidisciplinary techniques for reconstruction of complex cranial and scalp defects. Data on patient characteristics, initial treatment, and preparatory and definitive reconstructive treatment were retrospectively collected. Outcomes were measured as full solution, partial solution, or failure. -RESULTS: Three patients had a full solution/wound closure, 5 had a partial solution, and 1 failed reconstructive attempt. Full solution patients tended to be younger, received reconstruction treatment modalities for longer periods of time, and had more definitive surgeries. Initial and preparatory surgeries did not tend to promote a full solution, though having fewer preparatory surgeries that were not related to wound vacuum-assisted closure use tended to be associated with a better outcome. Infection of the scalp or cranium did not tend to change the result. -CONCLUSIONS: Reconstructive salvage of complex cranial and scalp defects takes time, so patience and earlier recognition of need for atypical reconstruction is beneficial. Patient characteristics may influence outcomes, but judicious choice of materials and techniques is more critical to patient success. Use of a multidisciplinary approach to complex cranial and scalp reconstruction is a beneficial option for many patients for whom standard reconstruction methods are not viable.
C1 [Stroder, Madelyn; Litofsky, N. Scott] Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr, Columbia, MO 65211 USA.
   [Litt, Jeffrey S.] Univ Missouri, Div Acute Care Surg, Sch Med, One Hosp Dr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Litofsky, NS (通讯作者)，Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr, Columbia, MO 65211 USA.
EM litofskyn@health.missouri.edu
RI ; Litofsky, N. Scott/AEU-0703-2022
OI Stroder, Madelyn/0000-0003-1854-2791; Litofsky, N.
   Scott/0000-0001-6373-7462
FU University of Missouri School of Medicine in 2020
FX M. Stroder received a Summer Research Fellowship from University of
   Missouri School of Medicine in 2020 to conduct this research project.
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NR 39
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD AUG
PY 2021
VL 152
BP E549
EP E557
DI 10.1016/j.wneu.2021.06.041
EA JUL 2021
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA TS1ZH
UT WOS:000679455500024
PM 34144172
DA 2026-07-24
ER

PT J
AU Mujahid, AM
   Khalid, FA
   Ali, N
   Sajjad, Y
   Khan, H
   Tarar, MN
AF Mujahid, Abdul Malik
   Khalid, Farrukh Aslam
   Ali, Noor
   Sajjad, Yawar
   Khan, Husnain
   Tarar, Moazzam Nazeer
TI Vacuum-assisted Closure in Integration of Skin Graft Over Scalp Wounds:
   A Randomised Control Trial
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Split thickness graft; Vacuum-assisted closure; Seroma; Scalp soft
   tissue defect
ID NEGATIVE-PRESSURE; THERAPY
AB Objective: To compare outcome of split thickness graft with and without vacuum-assisted closure over the scalp soft tissue defects in terms of graft take and complications.
   Study Design: Randomised controlled trial.
   Place and Duration of Study: Department of Plastic Surgery, Jinnah Burns and Reconstructive Surgery Centre, Lahore, from June 2017 to June 2018.
   Methodology: Patients with scalp soft tissue defects were recruited for the study. Patients with history of poly trauma, hypertension and diabetes mellitus were excluded. Patients were randomly divided into two groups by balloting lottery method. In group A, simple dressing were done after split thickness skin graft; and into group B, VAC dressing was applied after split thickness skin graft. Outcome variables (graft take and complications rate at recipient site) were assessed clinically at 2 weeks and analysed by Chi-square test with p-value <= 0.05 was taken as significant.
   Results: Mean age of 120 patients was 33.44 +/- 14.65 years. Graft take was seen in 24 (40.0%) patients in group A and in 56 (93.3%) patients in group B (p = 0.0001). Seroma was recorded in eight (13.3%) in group A (simple dressing) patients and one patient (1.67%) in group B (VAC dressing, p = 0.015), hematoma was seen in 04 (6.67%) versus 0 (0.0%), respectively (p = 0.042) and graft edge dehiscence in 03 (5.0%) versus 0 (0.0%), respectively (p = 0.079).
   Conclusion: Outcome of split skin graft over scalp soft tissue defects with VAC dressing is better than simple dressing in terms of graft take and complications rate.
C1 [Mujahid, Abdul Malik; Khalid, Farrukh Aslam; Ali, Noor; Sajjad, Yawar; Khan, Husnain; Tarar, Moazzam Nazeer] Allama Iqbal Med Coll Lahore, Dept Plast Surg, Jinnah Burn & Reconstruct Surg Ctr, Lahore, Pakistan.
RP Mujahid, AM (通讯作者)，Jinnah Burn & Reconstruct Surg Ctr, Lahore, Pakistan.
EM Iqbalian_127@yahoo.com
RI Khalid, Farrukh Aslam/AGZ-2968-2022
OI Khalid, Farrukh Aslam/0000-0001-9954-8890
CR [Anonymous], 2017, J WOUND MANAGEMENT R, DOI DOI 10.22467/
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Cherubino M, 2013, ISRN PLASTIC SURG, V2013
   Chiummariello S, 2013, WOUNDS, V25, P324
   Evangelista Maristella S, 2013, Wounds, V25, P89
   Isaac AL, 2014, PRS-GLOB OPEN, V2, DOI 10.1097/GOX.0000000000000044
   Jacobs S, 2009, J PLAST RECONSTR AES, V62, P1331, DOI 10.1016/j.bjps.2008.03.024
   Lee DH, 2016, Journal of Korean Society for Microsurgery, V25, P29, DOI [10.15596/arms.2016.25.2.29, 10.15596/ARMS.2016.25.2.29, DOI 10.15596/ARMS.2016.25.2.29]
   Lin Samuel J, 2008, Semin Plast Surg, V22, P281, DOI 10.1055/s-0028-1095887
   Mohsin M, 2017, INDIAN J PLAST SURG, V50, P43, DOI 10.4103/ijps.IJPS_196_16
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   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
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   Nguyen TQ, 2015, J BURN CARE RES, V36, P324, DOI 10.1097/BCR.0000000000000089
   Petkar KS, 2011, BURNS, V37, P925, DOI 10.1016/j.burns.2011.05.013
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   Seidel D, 2014, TRIALS, V15, DOI 10.1186/1745-6215-15-334
NR 19
TC 5
Z9 7
U1 0
U2 7
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD FEB
PY 2020
VL 30
IS 2
BP 163
EP 167
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KM0NJ
UT WOS:000513813700011
PM 32036824
OA gold
DA 2026-07-24
ER

PT J
AU Sahin, MF
   Yazicioglu, A
   Beyoglu, MA
   Yekeler, E
AF Sahin, Mehmet Furkan
   Yazicioglu, Alkin
   Beyoglu, Muhammet Ali
   Yekeler, Erdal
TI Successful method in the treatment of complicated sternal dehiscence and
   mediastinitis: Sternal reconstruction with osteosynthesis system
   supported by vacuum-assisted closure
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA English
DT Article
DE Mediastinitis; sternal dehiscence; sternal reconstruction
ID RISK-FACTORS; STERNOTOMY; MANAGEMENT; WOUNDS
AB Background: This study aims to evaluate the results of the method we used to treat sternal dehiscence and mediastinitis due to median sternotomy following open heart surgery. Methods: Between July 2014 and March 2019, a total of 13 patients (8 males, 5 females; mean age: 60.3 +/- 2.9 years; range, 33 to 74 years) who underwent sternal reconstruction procedure and developed sternal dehiscence and mediastinitis after cardiac surgery were retrospectively analyzed. Data of the patients were retrieved from the hospital records. Results: Before the procedure, reconstruction was performed by using the Robiscek technique in three cases and a conventional rewiring technique was used in one case. Except for one case, all the other cases had sternal purulent discharge (n=12, 92%). Except for four cases, all cases had at least two fracture lines in the sternum (n=9, 69%). One to 10 sessions of (median=4) vacuum-assisted closure therapy were used in cases before the procedure. At least two bars were placed between the opposite ribs for sternal fixation. Except for three cases, all of the cases were placed transdiaphragmatic harvested omentum in the sternal cavity. Seroma and local infection recurrence occurred in two cases (n=2, 15.3%) and incisional hernia in one case (n=1, 7.6%). Thoracic stabilization was successfully achieved in all cases. Conclusion: Thoracic stabilization can be successfully achieved in complicated sternal dehiscence cases with sternal reconstruction with STRATOS system supported by vacuum-assisted closure therapy, until the culture turns negative in the preoperative period and by the use of transdiaphragmatic omentum intraoperatively inside the sternal cavity.
C1 [Sahin, Mehmet Furkan; Yazicioglu, Alkin; Beyoglu, Muhammet Ali; Yekeler, Erdal] Hlth Sci Univ, Ankara City Hosp, Dept Thorac Surg & Lung Transplantat, Ankara, Turkey.
C3 University of Health Sciences Turkey; City Hospital Ankara
RP Sahin, MF (通讯作者)，Ankara Sehir Hastanesi, Gogus Cerrahisi & Akciger Nakli Klin, TR-06800 Ankara, Turkey.
EM mfurys@hotmail.com
RI YEKELER, ERDAL/GQP-6086-2022; Şahin, Mehmet Furkan/GOH-0195-2022;
   Beyoglu, Muhammet Ali/ABH-2274-2021
OI Şahin, Mehmet Furkan/0000-0002-7652-624X; Beyoglu, Muhammet
   Ali/0000-0003-4038-630X
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Celik A, 2013, THORAC CARDIOV SURG, V61, P631, DOI 10.1055/s-0032-1331263
   Ceresa F, 2010, J CARDIOTHORAC SURG, V5, DOI 10.1186/1749-8090-5-53
   Chang EI, 2013, ANN PLAS SURG, V71, P84, DOI 10.1097/SAP.0b013e31824872d9
   Cicilioni OJ, 2005, PLAST RECONSTR SURG, V115, P1297, DOI 10.1097/01.PRS.0000156918.15595.85
   Claes L, 2002, J ORTHOP RES, V20, P1099, DOI 10.1016/S0736-0266(02)00044-X
   De Feo M, 2003, ANN THORAC SURG, V75, P538, DOI 10.1016/S0003-4975(02)04313-8
   Dohi S, 2010, GEN THORAC CARDIOVAS, V58, P415, DOI 10.1007/s11748-009-0545-7
   Francel TJ, 2001, ANN THORAC SURG, V72, P1411, DOI 10.1016/S0003-4975(00)02008-7
   Ghazi BH, 2008, ANN PLAS SURG, V60, P169, DOI 10.1097/SAP.0b013e318054718e
   Hirata N, 2003, ANN THORAC SURG, V76, P2104, DOI 10.1016/S0003-4975(03)00744-6
   Kirsch M, 2001, ANN THORAC SURG, V71, P1580, DOI 10.1016/S0003-4975(01)02452-3
   Levin LS, 2010, ANN THORAC SURG, V89, P1995, DOI 10.1016/j.athoracsur.2010.01.089
   Moreschi Alexandre Heitor, 2008, J. bras. pneumol., V34, P654
   Olbrecht VA, 2006, ANN THORAC SURG, V82, P902, DOI 10.1016/j.athoracsur.2006.04.058
   Pai S, 2007, ANN BIOMED ENG, V35, P808, DOI 10.1007/s10439-007-9272-3
   Raman J, 2012, ANN THORAC SURG, V94, P1854, DOI 10.1016/j.athoracsur.2012.07.085
   Randecker H, 2005, ANN THORAC SURG, V80, P2393, DOI 10.1016/j.athoracsur.2004.07.043
   Reyna GC, 2006, REV ESP CARDIOL, V59, P130
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   ROBICSEK F, 1977, J THORAC CARDIOV SUR, V73, P267
   Salihi S, 2019, TURK GOGUS KALP DAMA, V27, P15, DOI 10.5606/tgkdc.dergisi.2019.15659
   Shibata T, 2003, ANN THORAC SURG, V76, P956, DOI 10.1016/S0003-4975(03)00438-7
   Voss B, 2008, EUR J CARDIO-THORAC, V34, P139, DOI 10.1016/j.ejcts.2008.03.030
NR 24
TC 3
Z9 5
U1 0
U2 2
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD JAN
PY 2022
VL 30
IS 1
BP 57
EP 65
DI 10.5606/tgkdc.dergisi.2022.2095
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YQ9LG
UT WOS:000749623900002
PM 35444857
DA 2026-07-24
ER

PT J
AU Yücel, M
   Özpek, A
   Basak, F
   Kiliç, A
   Ünal, E
   Yüksekdag, S
   Acar, A
   Bas, G
AF Yucel, Metin
   Ozpek, Adnan
   Basak, Fatih
   Kilic, Ali
   Unal, Ethem
   Yuksekdag, Sema
   Acar, Aylin
   Bas, Gurhan
TI Fournier's gangrene: A retrospective analysis of 25 patients
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Aggressive surgical debridement; Fournier's gangrene; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MANAGEMENT; MORTALITY;
   STRATEGIES; PREDICTORS; DIAGNOSIS; THERAPY
AB BACKGROUND: Fournier's gangrene is a surgical emergency that progresses rapidly and insidiously and results in high morbidity and mortality rates unless it is immediately diagnosed and managed. Here we analyze the outcomes of patients who were followed up and treated for Fournier's gangrene.
   METHODS: We conducted a retrospective analysis of the medical data of 25 patients operated on for Fournier's gangrene between January 2010 and June 2015. The diagnosis of Fournier's gangrene was made by performing a physical examination. Patients who had genital, perineal, and perianal tenderness; induration; cyanosis; gangrene; and subcutaneous crepitation were considered as having Fournier's gangrene. Following resuscitation, aggressive surgical debridement was performed and vacuum-assisted closure (VAC) was conducted in addition to debridement in select patient. Repeat debridements were performed as requirement.
   RESULTS: This study included 25 patients. Fourteen patients (56%) were females and 11 (44%) were males. The mean age of the patients was 54.3 years (range: 27-82 years). The mean duration of hospital stay was 21.4 days; the mean number of debridements performed was 2.4. Thirteen patients (52%) had perianal abscesses, and 20 (80%) had diabetes mellitus. All patients underwent extensive debridement; 16 patients (64%) underwent VAC in addition to debridement. Patients undergoing VAC had significantly longer durations of hospital stay and a higher mean number of debridements performed (p=0.004 and p=0.048, respectively). An ostomy was made in one patient, and one patient died.
   CONCLUSION: In Fournier's gangrene, early diagnosis, effective resuscitation, aggressive debridement, and VAC application in suitable cases may reduce the morbidity and mortality rates and the need for an ostomy.
C1 [Yucel, Metin; Ozpek, Adnan; Basak, Fatih; Kilic, Ali; Unal, Ethem; Yuksekdag, Sema; Acar, Aylin] Umraniye Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Bas, Gurhan] Medeniyet Univ, Dept Gen Surg, Fac Med, Istanbul, Turkey.
C3 Istanbul Umraniye Training & Research Hospital; Istanbul Medeniyet
   University
RP Yücel, M (通讯作者)，Adem Yavuz Caddesi 1, TR-34773 Istanbul, Turkey.
EM drmetin69@mynet.com
RI ; BAS, GÜRHAN/MIO-6489-2025; acar, aylin/HJP-4087-2023; OZPEK,
   ADNAN/Q-7864-2018; Basak, Fatih/A-1531-2014; Yucel, Metin/KFS-4904-2024
OI Unal, Ethem/0000-0003-4056-4874; BAS, GÜRHAN/0000-0002-7542-8269; Basak,
   Fatih/0000-0003-1854-7437; acar, aylin/0000-0003-2378-4197; OZPEK,
   ADNAN/0000-0002-2051-256X; 
CR Assenza M, 2011, CLIN TER, V162, pE1
   Benjelloun EB, 2013, WORLD J EMERG SURG, V8, DOI 10.1186/1749-7922-8-13
   Canbaz H, 2010, ULUS TRAVMA ACIL CER, V16, P71
   Cuccia G, 2009, UROL INT, V82, P426, DOI 10.1159/000218532
   Czymek R, 2009, AM J SURG, V197, P168, DOI 10.1016/j.amjsurg.2008.07.053
   Eke N, 2000, BJS-BRIT J SURG, V87, P718, DOI 10.1046/j.1365-2168.2000.01497.x
   Erdogan A, 2016, EUR J TRAUMA EMERG S, V42, P513, DOI 10.1007/s00068-015-0572-2
   Furr J, 2017, UROLOGY, V102, P79, DOI 10.1016/j.urology.2016.09.021
   Geraci G, 2004, Ann Ital Chir, V75, P97
   Heiner JD, 2010, CAN J EMERG MED, V12, P528
   Korkut M, 2003, DIS COLON RECTUM, V46, P649, DOI 10.1007/s10350-004-6626-x
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   Li YD, 2014, WORLD J GASTROENTERO, V20, P7950, DOI 10.3748/wjg.v20.i24.7950
   Mallikarjuna MN, 2012, ISRN SURG, V2012, P937
   Morpurgo E, 2002, SURG CLIN N AM, V82, P1213, DOI 10.1016/S0039-6109(02)00058-0
   Norton KS, 2002, AM SURGEON, V68, P709
   Oguz A, 2015, INT SURG, V100, P934, DOI 10.9738/INTSURG-D-15-00036.1
   Oymaci E, 2014, TURK J SURG, V30, P85, DOI 10.5152/UCD.2014.2512
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Smith GL, 1998, BRIT J UROL, V81, P347
   Sorensen MD, 2009, J UROLOGY, V182, P2742, DOI 10.1016/j.juro.2009.08.050
   Taviloglu K, 2005, AM SURGEON, V71, P315
   Yanar H, 2006, WORLD J SURG, V30, P1750, DOI 10.1007/s00268-005-0777-3
   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 24
TC 25
Z9 30
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD SEP
PY 2017
VL 23
IS 5
BP 400
EP 404
DI 10.5505/tjtes.2017.01678
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA FN5SA
UT WOS:000416066800008
PM 29052826
OA Bronze
DA 2026-07-24
ER

PT J
AU Ferron, G
   Garrido, I
   Martel, P
   Gesson-Paute, A
   Classe, JM
   Letourneur, B
   Querleu, D
AF Ferron, Gwenael
   Garrido, Ignacio
   Martel, Pierre
   Gesson-Paute, Amelie
   Classe, Jean-Marc
   Letourneur, Benoit
   Querleu, Denis
TI Combined laparoscopically harvested omental flap with meshed skin grafts
   and vacuum-assisted closure for reconstruction of complex chest wall
   defects
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE chest wall; minimal invasive surgery; radiation therapy; wound closure;
   cancer; vacuum-assisted closure
ID STERNAL WOUND-INFECTION; CONSECUTIVE PATIENTS; GREATER OMENTUM;
   CARDIAC-SURGERY; BREAST; COVERAGE; THERAPY; TRANSPOSITION; EXPERIENCE;
   MANAGEMENT
AB Background: Chest wall reconstruction after radiation damage is a challenge in oncologic and plastic surgery. The defect can be reconstructed with laparoscopically harvested omental flap and meshed skin grafts. Our aim was to evaluate the use of vacuum-assisted closure (V.A.C.) in combination with laparoscopically harvested omental flap and meshed skin graft for treating these complex wounds.
   Methods: Between October 2003 and December 2004, 11 patients under-went a chest wall reconstruction with laparoscopic omentoplasty and V.A.C. treatment of severe chest wall radionecrosis after breast cancer treatment (n = 10) or for locally advanced breast cancer treated first by irradiation (n = 1).
   Results: Laparoscopic harvesting was uneventful in 10 cases. One patient had a laparoscopic transverse colic resection because of a middle colic artery injury. Mean time of the laparoscopic procedure was 53 minutes (range: 35-120). Wound surface area averaged 360 cm(2) (range: 80-750). The mean duration of V.A.C. treatment was 9.3 days (range: 6-16). Nine patients showed primary wound healing without adverse events. Complications occurred in 3 patients. One developed a pulmonary infection and died after healing during the postoperative course. One presented a partial flap loss, leading to delayed healing after 45 days. One patient with severe radiation damage and a complete brachial plexus paralysis required a shoulder amputation after an extensive necrosis. All but 1 patient are alive and resumed their normal daily activities.
   Conclusions: Combination of laparoscopic omentoplasty and V.A.C. can successfully be used for reconstruction of complex chest wall radiation damage.
C1 Claudius Regaud Canc Ctr, Dept Surg Oncol, F-31052 Toulouse, France.
   Rene Gauducheau Canc Ctr, Dept Surg Oncol, St Herblain, France.
   Kinet Concepts Inc, San Antonio, TX USA.
C3 UNICANCER; Universite de Toulouse (EPE); Institut Claudius Regaud;
   UNICANCER; Institut de Cancerologie de l'Ouest (ICO)
RP Ferron, G (通讯作者)，Claudius Regaud Canc Ctr, Dept Surg Oncol, 20-24 Rue Pont St Pierre, F-31052 Toulouse, France.
EM ferron.gwenael@claudiusregaud.fr
RI /P-6193-2014
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   Moues C M, 2005, J Wound Care, V14, P224
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NR 42
TC 23
Z9 27
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2007
VL 58
IS 2
BP 150
EP 155
DI 10.1097/01.sap.0000237644.29878.0f
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 131FP
UT WOS:000243854100006
PM 17245140
DA 2026-07-24
ER

PT J
AU Kall, S
   Kilpadi, D
   Reimers, K
   Choi, CYU
   Jahn, S
   Vogt, PM
AF Kall, S
   Kilpadi, D
   Reimers, K
   Choi, CYU
   Jahn, S
   Vogt, PM
TI Influence of foam and tubing material of the Vacuum Assisted Closure
   device (VAC®) on the concentration of transforming growth factor beta 1
   in wound fluid
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE Vacuum Assisted Closure device; transforming growth factor beta 1;
   technical method
AB Background and purpose: The Vacuum Assisted Closure(R) device (V.A.C.(R)) is commonly used for the treatment of problematic wounds. Furthermore, wound fluid can be easily collected with this device for research purposes. However, there is inadequate information as to whether the measurement of biomoieties of importance to wound healing is affected by the exposure of wound fluid to V.A.C(R) components, namely Polyurethane-foarn and tubing. This study is an attempt to evaluate whether exposure of wound fluid to either V.A.C(R) -components affects concentrations of transforming growth factor beta I (TGF-b1) in wound fluid.
   Material and method: Wound fluid was gathered from five decubital ulcer patients using the foil-technique and was exposed to sterile peaces of the V.A.C.(R) Polyurethane-foam, tubing material or nothing for zero, one or five hours. Saline served as control. The concentration of TGF-b1 was measured using sandwich-ELISA. The resulting data were analyzed using two-way ANOVA, Newman-Keuls and Bonferroni t-Test.
   Results: The concentration of TGF-b1 decreased significant in all three groups during the five hours of the experiment (p < 0.05). There was no significant decrease in TGF-b1 concentration at any time point in-between the groups.
   Conclusion: From this study, we conclude that wound-fluid collected from the V.A.C(R).-device via the polyurethane-foam or tubing for purposes of analyzing concentrations of TGF-beta 1 should not be different from fluid collected using the foil technique.
C1 Hannover Med Sch, Klinikum Oststadt, Klin Plast Hand & Wiederherstellungschirurg Med, D-30659 Hannover, Germany.
   Kinet Concept Inc, San Antonio, TX USA.
C3 Hannover Medical School
RP Kall, S (通讯作者)，Hannover Med Sch, Klinikum Oststadt, Klin Plast Hand & Wiederherstellungschirurg Med, Podbeilskistr 380, D-30659 Hannover, Germany.
EM kall.susanne@mh-hannover.de
RI Vogt, Peter/AAL-1332-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Demaria RG, 2003, J CARDIOVASC SURG, V44, P757
   HIDEYUKI Y, 2004, WOUND REPAIR REGEN, V12, pA10
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Penn Elaine, 2004, Br J Nurs, V13, P194
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 7
TC 3
Z9 3
U1 0
U2 0
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S113
EP S115
DI 10.1055/s-2004-822659
PG 3
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600035
PM 15168305
DA 2026-07-24
ER

PT J
AU Labanaris, AP
   Polykandriotis, E
   Horch, RE
AF Labanaris, Apostolos P.
   Polykandriotis, Elias
   Horch, Raymund E.
TI The effect of vacuum-assisted closure on lymph vessels in chronic wounds
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Chronic wounds; Vacuum-assisted closure; Lymph vessel proliferation
ID TUMOR LYMPHANGIOGENESIS; RECONSTRUCTIVE SURGERY; MONOCLONAL-ANTIBODY;
   NODE METASTASIS; UPPER EXTREMITY; THERAPY; FLAPS; OSTEOMYELITIS;
   INFECTIONS; FOUNDATION
AB Introduction: Chronic wounds come in various forms and result from a multitude of factors that play a detrimental role in the wound-heating process. A breakthrough in wound management came with the introduction of vacuum-assisted closure (VAC). Although numerous papers have been published suggesting that VAC is based upon its unique ability to accelerate the rate of granulation tissue production, enhance angiogenesis and remove excess chronic wound fluid, no attempts have been made to investigate its effect on lymph vessels.
   Patients and methods: From April 2005 to April 2006, 80 patients with chronic wounds were treated with VAC therapy and prospectively studied. The parameters included: the length of VAC treatment, the number of dressing changes, the number of days of hospitalisation and immunocytochemical lymphatic vessel density assessments.
   Results: Lymph vessel proliferation was noted in all types of wounds, up to the first dressing change, but as VAC therapy continued it was apparent that patients exhibiting the same type of wounds did not exhibit the same results. Additionally, the duration of VAC therapy, dressing changes and average number of days of hospitalisation were significantly less in some cases but also prolonged in others.
   Conclusion: VAC therapy seems to be inducing morphological and quantitative alterations on the lymph vessel network in a wound. The effect of VAC therapy varies greatly depending on the presence of underlying diseases and risk factors impairing wound heating.
   An increase in the density of lymph vessels manifested histologically correlates with a better clinical outcome, in terms of heating rates and hospitalisation time. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Etsevier Ltd. All rights reserved.
C1 [Labanaris, Apostolos P.; Polykandriotis, Elias; Horch, Raymund E.] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Labanaris, AP (通讯作者)，Stadenstr 60, D-90491 Nurnberg, Germany.
EM labanaris@web.de
RI ; Horch, Raymund E/H-8128-2019
OI Polykaniotis, Elias/0000-0002-8152-6420; Horch, Raymund
   E/0000-0002-6561-2353
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NR 42
TC 43
Z9 51
U1 1
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2009
VL 62
IS 8
BP 1068
EP 1075
DI 10.1016/j.bjps.2008.01.006
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 477JY
UT WOS:000268516500017
PM 18524708
DA 2026-07-24
ER

PT J
AU Hattori, K
   Numanoglu, A
   Cox, S
AF Hattori, Kengo
   Numanoglu, Alp
   Cox, Sharon
TI Temporary Vacuum-Assisted Closure of the Open Abdomen in Neonates
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE vacuum-assisted closure; open abdomen; neonate; temporary abdominal
   closure; abdominal compartment syndrome
ID PRESSURE WOUND THERAPY; ABDOMINAL WOUNDS; CHILDREN; INFANTS; EXPERIENCE
AB Introduction The need for open abdomen in the treatment of severely ill neonates will increase in time as more complex abdominal procedures are undertaken. However, the experience of temporary closure of an open abdomen using vacuum-assisted closure (VAC) system is still relatively limited in premature and term neonates. The aim of this study is to describe and review our experience in the use of temporary VAC of the open abdomen for neonates with varying pathological processes. Materials and Methods A retrospective folder review of all neonates treated with VAC for open abdomen over the study period of 2010 to 2014 at our institution was performed. Results A total of 15 neonates were included in this study. Mean gestational age and postbirth age at VAC application were 33.64.1 (28-40) weeks and 14 +/- 10.2 (2-30) days, respectively. Mean weight at VAC application was 1,797.7 +/- 730.8 (960-3,200) g. Initial diagnoses were necrotizing enterocolitis (seven), intestinal perforation (three), gastroschisis (two), congenital diaphragmatic hernia (two), and primary abdominal compartment syndrome (ACS) (one). Reasons for VAC application included confirmed ACS (2) and application to prevent ACS (13). Duration of VAC use was 4 +/- 3.4 (0-13) days during which 2 +/- 1.2 (1-5) applications were performed. Overall survival rate was 80% (12 of 15 patients). One patient with primary ACS died from sepsis with an open abdomen. The only potential VAC-related complication was an enterocutaneous fistula. Conclusion Temporary VAC of the open abdomen is a safe method of temporary abdominal closure to prevent ACS in high-risk postoperative conditions in neonates of any gestational age and birth weight.
C1 [Hattori, Kengo; Numanoglu, Alp; Cox, Sharon] Univ Cape Town, Red Cross War Mem Childrens Hosp, Div Paediat Surg, Klipfontein Rd, ZA-7700 Cape Town, Western Cape, South Africa.
C3 University of Cape Town
RP Hattori, K (通讯作者)，Univ Cape Town, Red Cross War Mem Childrens Hosp, Div Paediat Surg, Klipfontein Rd, ZA-7700 Cape Town, Western Cape, South Africa.
EM ken5hattori@gmail.com
RI Hattori, Kengo/AAJ-2995-2021; Cox, Sharon Gail/H-3038-2016; Numanoglu,
   Alp/ITW-0564-2023
OI Hattori, Kengo/0000-0003-2650-3370; Cox, Sharon
   Gail/0000-0002-3175-8741; Numanoglu, Alp/0000-0003-2026-6423
CR [Anonymous], 2009, PRINCIPLES BEST PRAC
   Baharestani MM, 2007, OSTOMY WOUND MANAG, V53, P75
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Carlotti APCP, 2009, PEDIATR CRIT CARE ME, V10, P115, DOI 10.1097/PCC.0b013e31819371b2
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NR 19
TC 8
Z9 9
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2017
VL 27
IS 5
BP 437
EP 442
DI 10.1055/s-0036-1598010
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA FJ7LD
UT WOS:000412938300011
PM 28099974
DA 2026-07-24
ER

PT J
AU Saadi, A
   Perentes, JY
   Gonzalez, M
   Tempia, AC
   Wang, YB
   Demartines, N
   Ris, HB
   Krueger, T
AF Saadi, Alend
   Perentes, Jean Yannis
   Gonzalez, Michel
   Tempia, Adrien Caliera
   Wang, Yabo
   Demartines, Nicolas
   Ris, Hans-Beat
   Krueger, Thorsten
TI Vacuum-Assisted Closure Device: A Useful Tool in the Management of
   Severe Intrathoracic Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 46th Annual Meeting of the Society-of-Thoracic-Surgeons
CY JAN 25-27, 2010
CL Ft Lauderdale, FL
SP Soc Thorac Surg
ID POSTPNEUMONECTOMY EMPYEMA; ACCELERATED TREATMENT; NEGATIVE-PRESSURE;
   CLAGETT PROCEDURE; WOUND CONTROL; THERAPY; EXPERIENCE; SEPSIS
AB Background. This study is an evaluation of the vacuum-assisted closure (VAC) therapy for the treatment of severe intrathoracic infections complicating lung resection, esophageal surgery, viscera perforation, or necrotizing pleuropulmonary infections.
   Methods. We reviewed the medical records of all patients treated by intrathoracic VAC therapy between January 2005 and December 2008. All patients underwent surgical debridement-decortication and control of the underlying cause of infection such as treatment of bronchus stump insufficiency, resection of necrotic lung, or closure of esophageal or intestinal leaks. Surgery was followed by intrathoracic VAC therapy until the infection was controlled. The VAC dressings were changed under general anesthesia and the chest wall was temporarily closed after each dressing change. All patients received systemic antibiotic therapy.
   Results. Twenty-seven patients (15 male, median age 64 years) underwent intrathoracic VAC dressings for the management of postresectional empyema (n = 8) with and without bronchopleural fistula, necrotizing infections (n = 7), and intrathoracic gastrointestinal leaks (n = 12). The median length of VAC therapy was 22 days (range 5 to 66) and the median number of VAC changes per patient was 6 (range 2 to 16). In-hospital mortality was 19% (n = 5) and was not related to VAC therapy or intrathoracic infection. Control of intrathoracic infection and closure of the chest cavity was achieved in all surviving patients.
   Conclusions. Vacuum-assisted closure therapy is an efficient and safe adjunct to treat severe intrathoracic infections and may be a good alternative to the open window thoracostomy in selected patients. Long time intervals in between VAC changes and short course of therapy result in good patient acceptance. (Ann Thorac Surg 2011;91:1582-90) (C) 2011 by The Society of Thoracic Surgeons
C1 [Krueger, Thorsten] CHU Vaudois, Dept Thorac & Vasc Surg, Div Thorac & Vasc Surg, CH-1011 Lausanne, Switzerland.
   CHU Vaudois, Div Visceral Surg, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Krueger, T (通讯作者)，CHU Vaudois, Dept Thorac & Vasc Surg, Div Thorac & Vasc Surg, CH-1011 Lausanne, Switzerland.
EM thorsten.krueger@chuv.ch
RI ; Saadi, Alend/HGT-8854-2022; Krueger, Thorsten/AAK-1780-2021
OI gonzalez, michel/0000-0001-8705-4279; Saadi, Alend/0000-0002-4039-0811;
   Demartines, Nicolas/0000-0002-1530-3114; Perentes,
   Jean/0000-0001-7918-0793
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   Zaheer S, 2006, ANN THORAC SURG, V82, P279, DOI 10.1016/j.athoracsur.2006.01.052
NR 28
TC 43
Z9 59
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD MAY
PY 2011
VL 91
IS 5
BP 1582
EP 1590
DI 10.1016/j.athoracsur.2011.01.018
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 754EE
UT WOS:000289835000063
PM 21354551
DA 2026-07-24
ER

PT J
AU Hao, Y
   He, J
   Zhao, Z
   Li, C
   Feng, Z
AF Hao, Y.
   He, J.
   Zhao, Z.
   Li, C.
   Feng, Z.
TI 撤稿声明: Clinical Efficacy of Flap Transplantation Combined With Vacuum
   Sealing Drainage and Methylprednisolone and Cyclosporine in the
   Treatment of Pyoderma Gangrenosum
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 02 November 2022, in Wiley Online Library (), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. In addition, the investigation found that the authors provided incomplete ethical approval information for the study. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
CR Hao YH, 2023, INT WOUND J, V20, P1491, DOI 10.1111/iwj.14003
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70559
DI 10.1111/iwj.70559
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9900
UT WOS:001623091700001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shi, ZY
   Li, XW
   Hou, SL
   Wang, BH
   Yang, R
AF Shi, Zeyao
   Li, Xiaowen
   Hou, Shulin
   Wang, Bihua
   Yang, Ru
TI Infectious Wound Healing After Surgical Resection of Giant
   Sacrococcygeal Teratoma in an Infant: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE infant; newborn; sacrococcygeal teratoma; wound healing
AB An infant diagnosed with sacrococcygeal teratoma was referred to the authors' hospital. On day 5 of admission, the infant underwent complete surgical resection of the tumor. Unfortunately, the wound was infected by Enterobacter cloacae and dehisced. Advanced dressings combined with vacuum sealing drainage were applied to facilitate wound healing. Eighteen days postsurgery, the wound showed good epithelialization, and the patient was discharged. The patient received regular dressing changes at a local hospital, and follow-up was conducted through telephone for 3 months. After 3 months, scar tissue formation was observed, and no complications were reported.
C1 [Shi, Zeyao; Li, Xiaowen; Hou, Shulin; Wang, Bihua; Yang, Ru] Sichuan Univ, West China Second Univ Hosp, Dept Neonatol, 20,Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Shi, Zeyao; Li, Xiaowen; Hou, Shulin; Wang, Bihua; Yang, Ru] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Li, XW (通讯作者)，Sichuan Univ, West China Second Univ Hosp, Dept Neonatol, 20,Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
EM zeyao-shi@scu.edu.cn; xiaowenli@scu.edu.cn; 1281984307@qq.com;
   1692235914@qq.com
OI Junco, Judy Von/0009-0003-5977-5249
CR Alganabi M, 2021, PEDIATR SURG INT, V37, P973, DOI 10.1007/s00383-021-04911-4
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   Derikx JPM, 2007, J PEDIATR SURG, V42, P1122, DOI 10.1016/j.jpedsurg.2007.01.050
   Ferry A, 2020, BMC INFECT DIS, V20, DOI 10.1186/s12879-020-05406-8
   Francesko A, 2018, CURR MED CHEM, V25, P5782, DOI 10.2174/0929867324666170920161246
   Jung JA, 2016, ADV SKIN WOUND CARE, V29, P546, DOI 10.1097/01.ASW.0000508178.67430.34
   Kremer MEB, 2016, J PEDIATR SURG, V51, P1826, DOI 10.1016/j.jpedsurg.2016.07.005
   Leaper David J, 2006, Int Wound J, V3, P282, DOI 10.1111/j.1742-481X.2006.00265.x
   Li HZ, 2017, J SURG RES, V215, P98, DOI 10.1016/j.jss.2017.03.040
   Sanders WE, 1997, CLIN MICROBIOL REV, V10, P220, DOI 10.1128/CMR.10.2.220
   Schattenkerk LDE, 2021, J PEDIATR SURG, V56, P1547, DOI 10.1016/j.jpedsurg.2021.01.018
   Yamamichi T, 2022, PEDIATR SURG INT, V38, P317, DOI 10.1007/s00383-021-05051-5
   Yang JS, 2011, CARBOHYD POLYM, V84, P33, DOI 10.1016/j.carbpol.2010.11.048
   Zhang LX, 2023, ASIAN J SURG, V46, P6085, DOI 10.1016/j.asjsur.2023.09.074
   Zhang M, 2020, INT J BIOL MACROMOL, V162, P1414, DOI 10.1016/j.ijbiomac.2020.07.311
   Zvizdic Z, 2021, ASIAN J SURG, V44, P607, DOI 10.1016/j.asjsur.2020.12.027
NR 22
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN-FEB
PY 2026
VL 39
IS 1
BP E62
EP E65
DI 10.1097/ASW.0000000000000365
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DH2YQ
UT WOS:001683401400006
PM 40982754
DA 2026-07-24
ER

PT J
AU Jorgensen, MG
   Toyserkani, NM
   Hyldig, N
   Chakera, AH
   Hölmich, LR
   Thomsen, JB
   Sorensen, JA
AF Jorgensen, Mads Gustaf
   Toyserkani, Navid Mohamadpour
   Hyldig, Nana
   Chakera, Annette Hougaard
   Holmich, Lisbet Rosenkrantz
   Thomsen, Jorn Bo
   Sorensen, Jens Ahm
TI Prevention of seroma following inguinal lymph node dissection with
   prophylactic, incisional, negative-pressure wound therapy (SEROMA
   trial): study protocol for a randomized controlled trial (vol 19, pg
   441, 2018)
SO TRIALS
LA English
DT Correction
AB Following publication of the original article [1], the authors reported that one of the authors' names is spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original publication of this article has been corrected.
C1 [Jorgensen, Mads Gustaf; Toyserkani, Navid Mohamadpour; Thomsen, Jorn Bo; Sorensen, Jens Ahm] Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
   [Hyldig, Nana] Odense Univ Hosp, Hans Christian Andersens Children Hosp, Odense, Denmark.
   [Chakera, Annette Hougaard; Holmich, Lisbet Rosenkrantz] Herlev Gentofte Hosp, Dept Plast Surg, Herlev, Denmark.
   [Toyserkani, Navid Mohamadpour] Roskilde Hosp, Dept Plast Surg, Roskilde, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital
RP Sorensen, JA (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Sdr Blvd 29, DK-5000 Odense, Denmark.
EM jens.sorensen@rsyd.dk
RI ; Sørensen, Jens Ahm/D-6279-2014; Hölmich, Lisbet/P-1614-2018
OI Jørgensen, Mads Gustaf/0000-0002-8755-3446; Hyldig,
   Nana/0000-0001-6758-6294; Sørensen, Jens Ahm/0000-0003-4903-0094; 
CR Jorgensen MG, 2018, TRIALS, V19, DOI 10.1186/s13063-018-2757-6
NR 1
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD OCT 19
PY 2018
VL 19
AR 570
DI 10.1186/s13063-018-2882-2
PG 1
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GX5QS
UT WOS:000447805700004
PM 30340647
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Coban, YK
AF Coban, Yusuf Kenan
TI Combination of Negative Pressure Wound Therapy and Hyalomatrix
   Application for Soft Tissue Defect of the Great Toe
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE great toe; soft tissue defect; combination therapy
AB Soft tissue defect of the hallux can be particularly difficult to manage because of the absence of local muscle tissue for coverage. The author presents his experience of a combination therapy for severe posttraumatic soft tissue defect of the hallux in a young patient.
C1 Inonu Univ, Fac Med, Dept Plast Surg, TR-44280 Malatya, Turkey.
C3 Inonu University
RP Coban, YK (通讯作者)，Inonu Univ, Fac Med, Dept Plast Surg, TR-44280 Malatya, Turkey.
EM ykenanc@yahoo.com
RI Coban, Yusuf Kenan/AAV-8105-2020
OI Coban, Yusuf Kenan/0000-0003-3009-8339
CR Cigna E, 2013, INT WOUND J, V10, P534, DOI 10.1111/j.1742-481X.2012.01011.x
   Demirtas Y, 2010, MICROSURG, V30, P24, DOI 10.1002/micr.20696
   Lau KN, 2008, ANN PLAS SURG, V60, P498, DOI 10.1097/SAP.0b013e31816fc388
   Price RD, 2006, TISSUE ENG, V12, P2985, DOI 10.1089/ten.2006.12.2985
   Xie X, 2010, J WOUND CARE, V19, P488
NR 5
TC 6
Z9 10
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 155
EP 156
DI 10.1177/1534734612456396
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010EX
UT WOS:000309078600005
PM 22843635
DA 2026-07-24
ER

PT J
AU Amin, N
   Homsombath, B
   Rumbaugh, J
   Craft-Coffman, B
   Fagan, SP
   Chowdhry, T
   Wilson, J
   Paglinawan, R
   Lussi, K
   Hassan, Z
AF Amin, Neha
   Homsombath, Bounthavy
   Rumbaugh, John
   Craft-Coffman, Beretta
   Fagan, Shawn P.
   Chowdhry, Tayseer
   Wilson, Joan
   Paglinawan, Rey
   Lussi, Karin
   Hassan, Zaheed
TI Single-Use Negative Pressure Wound Therapy Applied on Various Wound
   Types An Interventional Case Series
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Home healthcare; Negative pressure wound therapy; Single-use negative
   pressure wound therapy device; Wound healing
ID RECOMMENDATIONS
AB PURPOSE: The purpose of this study was to determine whether a single-use negative pressure wound therapy (NPWT) system achieves individualized goals of therapy when used to treat patients with a variety of wound types.
   DESIGN: Multiple case series.
   SUBJECTS AND SETTING: The same comprised 25 participants; their mean age was 51.2 years (SD: 18.2; range: 19-79 years); 14 were male (56%) and 11 were female (44%). Seven study participants withdrew from study participation. Wound etiologies vary; 4 had diabetic foot ulcers; 1 had a full-thickness pressure injury; 7 were treated for management of an abscess or cyst; 4 had necrotizing fasciitis, 5 had nonhealing postsurgical wounds, and 4 had wounds of other etiologies. Data were collected at 2 ambulatory wound care clinics located in the Southeastern United States (Augusta and Austell, Georgia).
   METHODS: A single-outcome measure was selected for each participant by his or her attending physician at a baseline visit. Selected end points were (1) decrease in wound volume, (2) decrease in size of the tunneling area, (3) decrease in size of the undermining, (4) decrease in the amount of slough, (5) increase in granulation tissue formation, (6) decrease in periwound swelling, and (7) wound bed progression toward transition to another treatment modality (such as standard dressing, surgical closure, flap, or graft). Progress toward the individualized goal was monitored until the goal was achieved (study end point) or a maximum of 4 weeks following initiation of treatment.
   RESULTS: The most common primary treatment goal was to achieve a decrease in wound volume (22 of 25 study participants), and the goal to increase granulation tissue was chosen for the remaining 3 study participants. A majority of participants (18 of 23, 78.3%) reached their individualized treatment outcome. The remaining 5 participants (21.7%) were withdrawn during the study (for reasons not related to the therapy). The median (interquartile range [IQR]) duration of NPWT therapy was 19 days (IQR: 14-21 days). Between baseline and the final assessment, median reductions in wound area and volume were 42.7% (IQR: 25.7-71.5) and 87.5% (IQR: 30.7-94.6).
   CONCLUSIONS: The single-use NPWT system achieved multiple individualized treatment objectives in a variety of wound types. Individually selected goals of therapy were met by all study participants who completed the study.
C1 [Amin, Neha; Homsombath, Bounthavy; Rumbaugh, John; Craft-Coffman, Beretta; Fagan, Shawn P.; Chowdhry, Tayseer; Hassan, Zaheed] JMS Burn Ctr Inc, Austell, GA USA.
   [Amin, Neha; Homsombath, Bounthavy; Rumbaugh, John; Craft-Coffman, Beretta; Fagan, Shawn P.; Chowdhry, Tayseer; Hassan, Zaheed] Wellstar Hosp, Adv Wound Clin, Austell, GA USA.
   [Wilson, Joan] JMS Res Fdn Inc, Augusta, GA USA.
   [Lussi, Karin] Medela AG, Laettich Str, Baar, Switzerland.
RP Paglinawan, R (通讯作者)，Medela AG, Laettich Str 4b, CH-6340 Baar, Switzerland.
EM neha.amin@burncenters.com; v.homsombath@burncenters.com;
   john.rumbaugh@burncenters.com; beretta.coffman@burncenters.com;
   shawn.fagan@burncenters.com; tayseer.chowdhry@burncenters.com;
   joan.wilson@jmsresearchfoundation.org; rey.paglinawan@medela.com;
   karin.lussi@medela.com; zaheed.hassan@burncenters.com
FU Medela AG
FX Funding for writing of the manuscript and performance of this clinical
   study was provided by Medela AG. Rey Paglinawan and Karin Lussi are
   employees of Medela AG (Switzerland). For the remaining authors, no
   conflicts of interest were declared.
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Banasiewicz T, 2019, Wounds International, V10, P56
   Birke-Sorensen H, 2011, J PLAST RECONSTR AES, V64, pS1, DOI 10.1016/j.bjps.2011.06.001
   Crumley C, 2021, J WOUND OSTOMY CONT, V48, P195, DOI 10.1097/WON.0000000000000761
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Gottrup F, 2010, J WOUND CARE, V19, P239
   Hurd T, 2021, WOUNDS, V33, pS1
   Marquardt C, 2014, COLOPROCTOLOGY, V36, P364, DOI 10.1007/s00053-014-0478-1
   Morrison Informatics Inc, 2006, A Comprehensive Cost Analysis of Medicare Home Oxygen Therapy: A Study for the American Association for Homecare
   Mullins RF, 2023, WOUNDS, V35, P53, DOI 10.25270/wnds/22019
   Sen CK, 2021, ADV WOUND CARE, V10, P281, DOI 10.1089/wound.2021.0026
NR 11
TC 3
Z9 3
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2023
VL 50
IS 3
BP 203
EP 208
DI 10.1097/WON.0000000000000967
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA T2UN4
UT WOS:001076587200006
PM 37146110
OA hybrid
DA 2026-07-24
ER

PT J
AU Almodovar, LFL
   Bustos, G
   Lima, P
   Cañas, A
   Paredes, I
   Buendia, JA
AF Lopez Almodovar, Luis F.
   Bustos, Gema
   Lima, Pedro
   Canas, Alfonso
   Paredes, Isidro
   Buendia, Jose A.
TI Transverse plate fixation of sternum:: A new sternal-sparing technique
SO ANNALS OF THORACIC SURGERY
LA English
DT Editorial Material
ID ASSISTED CLOSURE THERAPY; WOUND-INFECTION; SYSTEM
AB We report 2 cases of vacuum-assisted closure therapy and thoracic reconstruction using new sternum titatium plates in patients with deep sternal wound infection after median sternotomy. The specific advantage of this new approach is anatomical reduction of the sternum that prevents paradoxical movement and severe anterior chest instability, and improves postoperative outcome.
C1 [Lopez Almodovar, Luis F.] Virgen Salud Hosp, Dept Cardiac Surg, Toledo 45005, Spain.
   Virgen Salud Hosp, Dept Plast Surg, Toledo 45005, Spain.
   Virgen Salud Hosp, Dept Cardiac Anesthesia, Toledo 45005, Spain.
RP Almodovar, LFL (通讯作者)，Virgen Salud Hosp, Dept Cardiac Surg, Avda Barber 30, Toledo 45005, Spain.
EM lopezalmodovar@yahoo.es
RI Lima Cañadas, Peo Pablo/W-3590-2017; Lima, Pedro/W-3590-2017
OI Lima Cañadas, Peo Pablo/0000-0002-7867-6196; 
CR Cicilioni OJ, 2005, PLAST RECONSTR SURG, V115, P1297, DOI 10.1097/01.PRS.0000156918.15595.85
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Hallock GG, 2007, ANN PLAS SURG, V58, P640, DOI 10.1097/01.sap.0000248134.37753.1a
   Plass A, 2007, ANN THORAC SURG, V83, P1210, DOI 10.1016/j.athoracsur.2006.03.080
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
NR 6
TC 12
Z9 14
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2008
VL 86
IS 3
BP 1016
EP 1017
DI 10.1016/j.athoracsur.2008.02.046
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 340AT
UT WOS:000258619100052
PM 18721609
DA 2026-07-24
ER

PT J
AU Liu, Y
   Song, J
   Xu, LL
   Huang, XJ
   Lan, HT
   Qin, WG
   Ernest, MER
AF Liu, Yi
   Song, Jian
   Xu, Li-Li
   Huang, Xiao-jun
   Lan, Hai-tao
   Qin, Wen-gang
   Ernest, Mendame Ehya Regis
TI VASCULARIZED FIBULAR GRAFT COMBINED WITH VACUUM ASSISTED CLOSURE IN THE
   RECONSTRUCTION OF TIBIAL DEFECTS
SO AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
LA English
DT Article
DE Tibial defect; Flow-through fibular graft; Vacuum Assisted Closure;
   Chronic Osteomyelitis
ID PRESSURE WOUND THERAPY; BONE DEFECTS; LONG BONES; MANAGEMENT; ALLOGRAFT;
   TUMORS; FLAP; KNEE
AB Background: To investigate the application of Flow-through free vascularized fibular graft combined with Vacuum Assisted Closure for the patients suffering from tibial defects caused by chronic osteomyelitis.
   Methods: We retrospectively analysed 20 cases of patients who accepted this operation in the treatment of tibial defects. Among the tibial defects, six cases resulted from blood stream infection while 14 cases resulted from comminuted fractures. All the patients included in the study were accompanied with 1 to 3 sinuses. The length of the defects ranged from 6cm to 16cm, with an average of 11.3cm. 6 patients were also faced with soft tissues defects combined with tendon or bone exposures, and the defects areas ranged from 11cmx7cm to 19cmx14cm. There were 5 patients suffering from fibular fractures at the same side of the defects. The courses of this disease were 5.5 -15 months, with an average of 9.8 months.
   Results: The patients included in the study were followed up from 10 months to 4 years, with an average of 1.9 years. Sinuses of 18 patients healed within 4 weeks, giving a primary healing rate of 90%. We undertook debridement of the remaining sinuses and they healed within 2 weeks. All skin flaps grafted to the patients survived, thus the survival rate was 100%. The radiographs indicated that 18 patients had good prognosis and the primary union time of grafting fibula were from 4 to 8 months, with average of 6.3 months. The healing patients achieved an average of 25.6 points based on the Enneking evaluation system which was used to evaluate the function of limbs after the operation, indicating that 85.9% of the limb function recovered. 4 patients required revision surgery for complications resulting from the operation: 1 wound breakdown, 2 bone non-unions, 1 graft fracture. Infection occurred only as a pin-tract infection, and was controlled with oral antibiotics and repeated dressing; there was no deep infection out of control in any of these patients.
   Conclusion: The flow-through free vascularized fibular graft did not only repair tibial defects, but retained the continuity of trunk vessels. The flow-through fibular graft combined with Vacuum Assisted Closure (VAC) controlled the infection, shortened the course of treatment, and effectively restored limb function when applied to the treatment of tibial defects.
C1 [Liu, Yi] Hubei Univ Med, Taihe Hosp, Dept Orthoped 5, Shiyan City, Hubei Province, Peoples R China.
   [Song, Jian; Ernest, Mendame Ehya Regis] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Peoples R China.
   [Xu, Li-Li] Hubei Univ Med, Taihe Hosp, Dept Neurol, Shiyan City, Hubei Province, Peoples R China.
   [Huang, Xiao-jun; Lan, Hai-tao] Hubei Univ Med, Dongfeng Hosp, Dept Urol, Shiyan City, Hubei Province, Peoples R China.
   [Qin, Wen-gang] Hubei Univ Med, Dongfeng Hosp, Dept Sci Res & Educ, Shiyan City, Hubei Province, Peoples R China.
C3 Hubei University of Medicine; Wuhan University; Hubei University of
   Medicine; Hubei University of Medicine; Hubei University of Medicine
RP Song, J (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Peoples R China.
EM 731171798@qq.com; songjianwhu@sina.com
OI Mendame ehya, Regis ernest/0000-0003-3275-6649
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NR 32
TC 3
Z9 3
U1 0
U2 10
PU AFRICAN NETWORKS ETHNOMEDICINES
PI ILE-IFE
PA OBAFEMI AWOLOWO UNIV,CLEMENT O ADEWUNMI, DRUG RES PROD UNIT, FAC
   PHARMACY, ILE-IFE, 00000, NIGERIA
SN 0189-6016
J9 AFR J TRADIT COMPLEM
JI Afr. J. Tradit. Complement. Alt. M.
PY 2015
VL 12
IS 6
BP 27
EP 32
DI 10.4314/ajtcam.v12i6.4
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CX7NG
UT WOS:000365888200004
OA gold
DA 2026-07-24
ER

PT J
AU Carney, BC
   Johnson, LS
   Shupp, JW
   Travis, TE
AF Carney, Bonnie C.
   Johnson, Laura S.
   Shupp, Jeffrey W.
   Travis, Taryn E.
TI Initial Experience Combining Negative Pressure Wound Therapy With
   Autologous Skin Cell Suspension and Meshed Autografts
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID GRAFT
AB The success of autologous split-thickness skin grafts (STSGs) in the treatment of full-thickness burns is often dependent on the dressing used to secure it. Tie-over bolsters have been used traditionally; however, they can be uncomfortable for patients and preclude grafting large areas in one definitive operation. Negative pressure wound therapy (NPWT) is used as an alternative to bolster dressings and may afford additional wound healing benefits. In our center, NPWT has become the dressing of choice for securing STSGs. While the RECELL (R) system is being used in conjunction with STSGs, it is currently unknown whether autologous skin cell suspensions (ASCS) can be used with NPWT. This report is a retrospective chart review of nine patients treated in this manner. All wounds were almost completely re-epithelialized within 14 days, and their healing was as expected. Wound healing trajectories are shown. There were no significant complications in these patients. This dressing technique can be considered as an option when using ASCS and widely meshed STSG.
C1 [Carney, Bonnie C.; Shupp, Jeffrey W.] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA.
   [Carney, Bonnie C.; Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC USA.
   [Carney, Bonnie C.; Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] Georgetown Univ, Sch Med, Dept Surg, Washington, DC USA.
   [Johnson, Laura S.; Shupp, Jeffrey W.; Travis, Taryn E.] MedStar Washington Hosp Ctr, Burn Ctr, Dept Surg, 110 Irving St NW,Suite 3B-55, Washington, DC 20010 USA.
C3 Georgetown University; MedStar Health Research Institute; Georgetown
   University; MedStar Washington Hospital Center
RP Travis, TE (通讯作者)，MedStar Washington Hosp Ctr, Burn Ctr, Dept Surg, 110 Irving St NW,Suite 3B-55, Washington, DC 20010 USA.
EM Taryn.E.Travis@medstar.net
RI Shupp, Jeffrey/AAW-3481-2021; Travis, Taryn/AAK-8527-2021; Johnson,
   Laura S/ABE-5478-2020
OI Johnson, Laura S/0000-0001-6969-2648
CR Carney BC, J SURG RES, V2021
   Chiu T, 2005, CLIN DERMATOL, V23, P419, DOI 10.1016/j.clindermatol.2004.07.027
   Chou PR, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55120781
   Holmes JH, 2019, BURNS, V45, P772, DOI 10.1016/j.burns.2018.11.002
   Holmes JH, 2018, J BURN CARE RES, V39, P694, DOI 10.1093/jbcr/iry029
   Inatomi Y, 2019, J WOUND CARE, V28, pS16, DOI 10.12968/jowc.2019.28.Sup8.S16
   Kantak NA, 2017, CLIN PLAST SURG, V44, P671, DOI 10.1016/j.cps.2017.02.023
   Kantak NA, 2016, BURNS, V42, P1623, DOI 10.1016/j.burns.2016.06.011
   Karlsson M, 2018, ADV SKIN WOUND CARE, V31, P183, DOI 10.1097/01.ASW.0000530684.31491.5f
   Kowal S, 2019, ADV THER, V36, P1715, DOI 10.1007/s12325-019-00961-2
   Nosanov LB, 2017, J SURG RES, V216, P185, DOI 10.1016/j.jss.2017.05.004
   Singer AJ, 2016, PLAST RECONSTR SURG, V137, p972E, DOI 10.1097/PRS.0000000000002161
   Stoddard FJ, 2014, SURG CLIN N AM, V94, P863, DOI 10.1016/j.suc.2014.05.007
   Teng SC, 2016, INT WOUND J, V13, P15, DOI 10.1111/iwj.12641
   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
   Wood FM, 2012, BURNS, V38, P44, DOI 10.1016/j.burns.2011.03.001
NR 16
TC 5
Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2021
VL 42
IS 4
BP 633
EP 641
DI 10.1093/jbcr/irab075
EA APR 2021
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA UE2WA
UT WOS:000687752900007
PM 33903907
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Traylor, LB
   Bhatia, G
   Blackhurst, D
   Wallenborn, G
   Ewing, A
   Bolton, W
   Davis, B
AF Traylor, L. B.
   Bhatia, G.
   Blackhurst, D.
   Wallenborn, G.
   Ewing, A.
   Bolton, W.
   Davis, B.
TI Efficacy of incisional negative pressure therapy in preventing
   post-sternotomy wound complications
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID RISK-FACTORS; INFECTION; MANAGEMENT; SITE; MORTALITY; CLOSURE
AB Background: Sternal wound infections represent a source of significant morbidity and mortality following median sternotomy. The use of incisional negative pressure wound therapy in prevention has yet to be elucidated.
   Methods: A retrospective study was conducted before and after a universal wound care protocol was implemented including the prophylactic use of negative pressure wound therapy (NPWT). The primary endpoint was sternal infections within 90 days of the index operation.
   Results: In the control period, there was a 3.0% rate of sternal infection within 90 days compared to 0.8% in the intervention period (p < 0.001). An odds ratio of 0.25 (95% confidence interval 0.11, 0.57; p < 0.001) in the intervention period as compared to the control period was demonstrated.
   Conclusions: The use of a standardized wound care protocol including the universal application of NPWT for patients undergoing cardiac surgery with median sternotomy was an independent predictor of decreased rates of sternal infection.
   (c) 2023 Elsevier Inc. All rights reserved.
C1 [Traylor, L. B.] Univ South Carolina, Sch Med Greenville, Greenville, SC 29605 USA.
   [Bhatia, G.; Blackhurst, D.; Wallenborn, G.; Ewing, A.; Bolton, W.; Davis, B.] Prisma Hlth Upstate, Greenville, SC 29605 USA.
C3 Prisma Health
RP Bhatia, G (通讯作者)，Prisma Hlth Upstate, Greenville, SC 29605 USA.
EM gautam.bhatia@prismahealth.org
OI Bhatia, Gautam/0009-0007-1029-3395; Traylor, Lawson/0000-0001-5684-2176
CR Al-Ebrahim KE, 2020, HEART SURG FORUM, V23, pE652, DOI [10.1532/hsf.3153Prevention, 10.1532/hsf.3153]
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   Chello C, 2020, SURG TECHNOL INT, V36
   Colombier S, 2013, MED SCI MONITOR, V19, P668, DOI 10.12659/MSM.889191
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   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
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   Levy AS, 2021, PLAST RECONSTR SURG, V148, P429, DOI 10.1097/PRS.0000000000008168
   Madjarov JM, 2021, J CARDIAC SURG, V36, P3155, DOI 10.1111/jocs.15687
   Magro PL, 2021, INTERACT CARDIOV TH, V32, P452, DOI 10.1093/icvts/ivaa292
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   Morisaki A, 2011, GEN THORAC CARDIOVAS, V59, P261, DOI 10.1007/s11748-010-0727-3
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   Sjögren J, 2011, INTERACT CARDIOV TH, V12, P117, DOI 10.1510/icvts.2010.252668
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   Tabley A, 2020, ANN THORAC SURG, V110, P2034, DOI 10.1016/j.athoracsur.2020.03.087
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NR 34
TC 4
Z9 4
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD DEC
PY 2023
VL 226
IS 6
BP 762
EP 767
DI 10.1016/j.amjsurg.2023.07.016
EA NOV 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CI4A2
UT WOS:001124598300001
PM 37453803
DA 2026-07-24
ER

PT J
AU Kiehn, MW
   Heckman, WW
   Osaki, S
   Kohmoto, T
AF Kiehn, Mark W.
   Heckman, W. Wesley
   Osaki, Satoru
   Kohmoto, Takushi
TI Intercostal muscle flap reconstruction and primary sternal closure for
   mediastinal abscess
SO ANNALS OF THORACIC SURGERY
LA English
DT Editorial Material
ID MANAGEMENT
AB Poststemotomy mediastinal abscess is a life-threatening complication after cardiac operations. A 21-year-old woman had a late presentation of mediastinal abscess 9 years after ascending aortic graft replacement. Three days after the initial debridement and vacuum-assisted closure treatment, successful reconstruction was performed using an intercostal muscle flap and primary sternal closure, without recurrent infection.
C1 [Kiehn, Mark W.] Univ Wisconsin, Sch Med & Publ Hlth, Div Craniofacial Microvasc Hand & Gen Reconstruct, Madison, WI USA.
   Univ Wisconsin, Sch Med & Publ Hlth, Div Cardiothorac Surg, Madison, WI USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Kiehn, MW (通讯作者)，Kaiser Permanente Franklin Med Ctr, Dept Plast Surg, 2045 Franklin, Denver, CO 80205 USA.
EM kiehn@surgery.wisc.edu
CR ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   KOHMAN LJ, 1991, ANN THORAC SURG, V52, P102, DOI 10.1016/0003-4975(91)91428-X
   Oh AK, 2006, ANN THORAC SURG, V82, P1894, DOI 10.1016/j.athoracsur.2006.03.030
   SARKAR SK, 1985, INT SURG, V70, P219
NR 5
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUL
PY 2008
VL 86
IS 1
BP 304
EP 306
DI 10.1016/j.athoracsur.2008.01.062
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 316FK
UT WOS:000256934400051
PM 18573448
OA Bronze
DA 2026-07-24
ER

PT J
AU Zahoor, B
   Kent, S
   Wall, D
AF Zahoor, Bilal
   Kent, Stephen
   Wall, Daryl
TI Cutaneous mucormycosis secondary to penetrative trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Mucormycosis; Trauma; Management; Treatment; Diagnosis
ID INFECTIONS; MANAGEMENT; INJURIES; PATIENT
AB Introduction: Mucormycosis is a rare but serious sequelae of penetrating trauma [1-5]. In spite of aggressive management, mortality remains high due to dissemination of infection. We completed a review of literature to determine the most optimal treatment of cutaneous mucormycosis which occurs secondary to penetrating trauma.
   Methods: We completed a review regarding the management of mucormycosis in trauma patients. We selected a total of 36 reports, of which 18 were case-based, for review.
   Results: Surgical debridement is a primary predictor of improved outcomes in the treatment of mucormycosis [3,6,7]. Anti-fungal therapy, especially lipid soluble formulation of Amphotericin B, is helpful as an adjunct or when surgical debridement has been maximally achieved. Further research is needed to fully evaluate the impact of topical dressings; negative pressure wound therapy is helpful.
   Conclusion: An aggressive and early surgical approach, even at the expense of disfigurement, is necessary to reduce mortality in the setting of cutaneous mucormycosis that results from penetrating trauma [4,8,9]. Anti-fungal therapy and negative pressure wound therapy are formidable adjuncts. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Zahoor, Bilal; Wall, Daryl] Royal Brisbane & Womens Hosp, Dept Trauma, Brisbane, Qld Au 4005, Australia.
   [Kent, Stephen] Royal Brisbane & Womens Hosp, Dept Orthopaed, Brisbane, Qld Au 4005, Australia.
   [Zahoor, Bilal; Wall, Daryl] Univ Queensland, Sch Med, Brisbane, Qld Au 4005, Australia.
   [Zahoor, Bilal] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD 21231 USA.
C3 Royal Brisbane & Women's Hospital; Royal Brisbane & Women's Hospital;
   University of Queensland; Johns Hopkins University
RP Zahoor, B (通讯作者)，Royal Brisbane & Womens Hosp, Dept Trauma, Brisbane, Qld Au 4005, Australia.
EM bilal.zahoor@uqconnect.edu.au
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NR 36
TC 17
Z9 18
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUL
PY 2016
VL 47
IS 7
BP 1383
EP 1387
DI 10.1016/j.injury.2016.03.011
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA DO8QL
UT WOS:000378048300003
PM 27126769
DA 2026-07-24
ER

PT J
AU Lehner, B
   Fleischmann, W
   Becker, R
   Jukema, GN
AF Lehner, Burkhard
   Fleischmann, Wim
   Becker, Rolf
   Jukema, Gerrolt N.
TI First experiences with negative pressure wound therapy and instillation
   in the treatment of infected orthopaedic implants: a clinical
   observational study
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
ID TOTAL KNEE ARTHROPLASTY; PROSTHETIC JOINT INFECTION; HIP-ARTHROPLASTY;
   DEBRIDEMENT; RETENTION; ANTIBIOTICS; REPLACEMENT
AB Infections associated with orthopaedic implants remain a serious complication. The main objective in acute infection control is component retention, whereas this option is usually not considered for chronic infections.
   This multi-centre prospective, non-randomised observational study investigated one possible treatment option for implant retention in combination with negative pressure wound therapy with instillation (NPWTi). Thirty-two patients with an infected orthopaedic implant were analysed. Twenty-two patients had an acute infection (< 8 weeks after implantation) and ten patients had a chronic infection (> 8 weeks and < 36 weeks after implant placement). Polyhexanide was used as the instillation solution in 31 of the 32 cases.
   Nineteen patients (86.4%) with an acute infection and eight patients (80%) with a chronic infection retained their implant at 4-6 months follow-up after treatment.
   Our study showed that NPWTi can be used as adjunctive therapy for salvage of acutely infected orthopaedic implants and may even be considered for early chronically infected implants.
C1 [Lehner, Burkhard] Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, D-69118 Heidelberg, Germany.
   [Fleischmann, Wim] Ludwigsburg Bietigheim Kliniken gGmbH, Dept Trauma & Reconstruct Surg, Bietigheim Bissingen, Germany.
   [Becker, Rolf] Eduarduskrankenhaus, Cologne, Germany.
   [Jukema, Gerrolt N.] Univ Zurich Hosp, Dept Trauma Surg, CH-8091 Zurich, Switzerland.
C3 Ruprecht Karls University Heidelberg; University of Zurich; University
   Zurich Hospital
RP Lehner, B (通讯作者)，Orthoped Univ Hosp, Dept Orthoped Oncol & Sept Orthoped Surg, Schlierbacher Landstr 200A, D-69118 Heidelberg, Germany.
EM burkhard.lehner@med.uni-heidelberg.de
FU Kinetic Concepts, Inc. (San Antonio, TX, USA)
FX This observational study was supported by Kinetic Concepts, Inc. (San
   Antonio, TX, USA). The setup of the study and evaluation of the data
   were performed by the individual members of the Steering Committee.
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   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Whitehouse JD, 2002, INFECT CONT HOSP EP, V23, P183, DOI 10.1086/502033
   Zimmerli W, 2004, NEW ENGL J MED, V351, P1645, DOI 10.1056/NEJMra040181
   Zywiel MG, 2011, INT ORTHOP, V35, P37, DOI 10.1007/s00264-010-0992-x
NR 28
TC 90
Z9 107
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
J9 INT ORTHOP
JI Int. Orthop.
PD SEP
PY 2011
VL 35
IS 9
BP 1415
EP 1420
DI 10.1007/s00264-011-1274-y
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 809OS
UT WOS:000294067200021
PM 21584643
OA Bronze
DA 2026-07-24
ER

PT J
AU Jin, L
   Niu, C
   Ni, YL
AF Jin, Liang
   Niu, Chao
   Ni, Yulong
TI Effect of vacuum sealing drainage combined with alprostadil and lipoic
   acid in the treatment of diabetic foot ulcer and its effect on
   inflammatory factors
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article; Early Access
DE Diabetic foot ulcer; Vacuum sealing drainage; Alprostadil; Lipoic acid;
   Efficacy; Inflammatory factor
ID PERIPHERAL NEUROPATHY; THERAPY; ALPHA; COMBINATION; EFFICACY; VELOCITY
AB Background Diabetic foot ulcer (DFU) is one of the most common complications in diabetic patients. In recent years, vacuum sealing drainage (VSD) therapy has been widely applied in clinical wound healing, effectively promoting wound healing and reducing the occurrence of infections. However, VSD therapy can only locally improve the wound microenvironment and is insufficient in regulating systemic inflammatory responses. Alprostadil, a prostaglandin, has shown certain effectiveness in the treatment of DFU by improving microcirculation and promoting blood flow. Lipoic acid, a potent antioxidant, can alleviate oxidative stress, improve metabolic abnormalities, and reduce inflammatory responses in diabetic patients, thereby promoting wound healing. The combined use of VSD, alprostadil, and lipoic acid may have a synergistic effect in the treatment of DFU. Objective This study conducts a retrospective analysis of clinical data from diabetic foot ulcer (DFU) patients treated at our institution to investigate the therapeutic efficacy of vacuum sealing drainage (VSD) combined with alprostadil and lipoic acid in treating DFUs, and its impact on inflammatory factors in patients. Methods A retrospective analysis was conducted on the clinical data of 98 patients diagnosed with DFU who were admitted to our hospital between January 2022 and February 2023. Based on their respective treatment protocols, the patients were categorized into two groups: the control group (n = 52) and the observation group (n = 46). All patients enrolled in the study underwent VSD treatment, with the observation group receiving additional alprostadil and lipoic acid supplementation. The therapeutic efficacy was evaluated for all participants 2 weeks after treatment initiation, and the wound healing time, the time of stopping using VSD and its hospitalization time, hospitalization expenses, and adverse reactions of the two groups were recorded. Furthermore, analyses included pre- and post-treatment assessments of growth factor levels in granulation tissue, alongside evaluations of fibrotic activity markers, oxidative stress indicators, inflammatory cytokine profiles, and arterial hemodynamics in both groups. Results. Results The observation group demonstrated a significantly higher effective rate of 93.48% (43/46) compared to 76.92% (40/52) in the control group, and the wound healing time of observer was lower than that of control group (p < 0.05). Post-treatment, levels of VEGF and PDGF in granulation tissue increased in both groups relative to pre-treatment levels, with higher levels observed in the observation group compared to the control group (p < 0.05). Post-treatment, levels of tPA, SOD, GSH-PX, CAT, blood flow velocity, vessel inner diameter, RI, and PI in both groups were higher than pre-treatment levels, while levels of FPA, PAI-1, CRP, IL-6, Hcy, and TNF-alpha were lower than pre-treatment levels. Additionally, the observation group exhibited higher levels of tPA, SOD, GSH-PX, CAT, blood flow velocity, vessel inner diameter, RI, and PI compared to the control group and lower levels of FPA, PAI-1, CRP, IL-6, Hcy, and TNF-alpha compared to the control group (p < 0.05). The time to stop using VSD, hospitalization time, and hospitalization expenses in the observation group was lower than those in the control group (p < 0.05).
   Conclusion The treatment of DFU with VSD combined with alprostadil and lipoic acid can significantly promote wound healing and granulation growth, shorten wound healing time, effectively enhance cellulase activity and antioxidant capacity of patients, relieve inflammation, and protect vascular endothelial cells, with high efficiency and safety, and effectively reduce the use time of VSD and the hospitalization time and expenses of patients, which is worthy of promotion.
C1 [Jin, Liang; Niu, Chao; Ni, Yulong] Xingtai Peoples Hosp, Dept Hand & Foot Surg, Xingtai 054000, Hebei, Peoples R China.
RP Jin, L (通讯作者)，Xingtai Peoples Hosp, Dept Hand & Foot Surg, Xingtai 054000, Hebei, Peoples R China.
EM jl00981009@163.com
FU Medical Science Research Project Plan of Hebei Province 2021 [20210053]
FX This study was supported by Medical Science Research Project Plan of
   Hebei Province 2021(20210053).
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NR 39
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD 2025 JUN 10
PY 2025
DI 10.1007/s13410-025-01504-y
EA JUN 2025
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3UQ4I
UT WOS:001509411400001
DA 2026-07-24
ER

PT J
AU Bobkiewicz, A
   Krokowicz, L
   Banasiewicz, T
   Borejsza-Wysocki, M
AF Bobkiewicz, Adam
   Krokowicz, Lukasz
   Banasiewicz, Tomasz
   Borejsza-Wysocki, Maciej
TI Endoscopic vacuum therapy with instillation (iEVT) - a novel endoscopic
   concept for colorectal anastomotic leak and perianal complications
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE anastomotic leakage; anal fistula; endoscopic vacuum therapy; negative
   pressure wound therapy
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; FOAM
AB Introduction: Anastomotic leaks remain the most fearful complications.
   Aim: We present a novel endoscopic salvage therapy known as endoscopic vacuum therapy with instillation (iEVT) as a combination of standard endoscopic vacuum therapy (EVT) and negative pressure wound therapy with instillation (iNPWT).
   Material and methods: A case series of 6 consecutive patients treated with iEVT is presented. A Redon drain and a central venous catheter were introduced within polyurethane foam used as a self-made device for iEVT and anti-microbial solution was instilled.
   Results: A total of 6 patients with the mean age of 29.5 +/- 8.9 were treated with iEVT. The mean number of iEVT sessions was 5.8 +/- 2.3. The mean time of iEVT management was 20.7 +/- 8.8 days. Locally, a reduction in purulent discharge and defect's dimension with contraction were revealed confirmed with imaging studies.
   Conclusions: iEVT is a very encouraging, novel method for complicated perianal diseases and anastomotic leak.
C1 [Bobkiewicz, Adam; Krokowicz, Lukasz; Banasiewicz, Tomasz; Borejsza-Wysocki, Maciej] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
EM bobofon007@gmail.com
CR Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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NR 15
TC 11
Z9 13
U1 0
U2 2
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 4
BP 560
EP 566
DI 10.5114/wiitm.2020.93204
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QD6LA
UT WOS:000615625900005
PM 33294070
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU González, JAJ
   Sánchez, CQ
   Rodríguez, FM
AF Jerez Gonzalez, Jose Antonio
   Quinones Sanchez, Cristina
   Marquez Rodriguez, Francisca
TI Catastrophic Abdominal Wall After Repair of Enterocutaneous Fistula A
   Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Absorbent polyacrylate fibers; Enterocutaneous fistula; Negative
   pressure wound therapy; Skin graft
ID INTESTINAL FAILURE; OPEN ABDOMEN; METAANALYSIS; MANAGEMENT; CLOSURE
AB BACKGROUND: Repair of an enterocutaneous fistula (ECF) is challenging, particularly when complications occur. This case describes the use of negative pressure wound therapy (NPWT) and microadhesive dressings with polyabsorbent fibers and an acrylic core, with and without lipidocolloid and nano-oligosaccharide factors, in the management of a patient with a large abdominal wound and ECF.
   CASE: An 84-year-old woman underwent abdominoperineal resection with colostomy, hysterectomy, and subsequent chemotherapy and radiotherapy for colorectal cancer. She experienced complications, ultimately resulting in ECF of the jejunum. Initial management with NPWT was used to promote abdominal wound healing, while protecting exposed bowel loops proved challenging because of leakage of stoma effluent that impeded the formation of granulation tissue. In order to promote wound healing and prevent infection, we applied a microadhesive dressing composed of polyabsorbent fibers with an acrylic core and lipidocolloid and nano-oligosaccharide factors that facilitated autolytic debridement and healing.
   CONCLUSIONS: Use of NPWT with the microadhesive dressing proved successful in the management of this complex and challenging ECF.
C1 [Jerez Gonzalez, Jose Antonio; Quinones Sanchez, Cristina; Marquez Rodriguez, Francisca] Bellvitge Univ Hosp, C Feixa Llarga S-N, Barcelona 08907, Spain.
C3 University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Bellvitge University Hospital
RP González, JAJ (通讯作者)，Bellvitge Univ Hosp, C Feixa Llarga S-N, Barcelona 08907, Spain.
EM jjerez@bellvitgehospital.cat
CR Adaba F, 2017, CLIN COLON RECT SURG, V30, P215, DOI 10.1055/s-0037-1598163
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   Falconi M, 2001, GUT, V49, pIV2, DOI 10.1136/gut.49.suppl_4.iv2
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   Kumar P, 2011, SAUDI J GASTROENTERO, V17, P391, DOI 10.4103/1319-3767.87180
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   Reider KE, 2017, J WOUND OSTOMY CONT, V44, P293, DOI 10.1097/WON.0000000000000329
   Schecter WP, 2009, J AM COLL SURGEONS, V209, P484, DOI 10.1016/j.jamcollsurg.2009.05.025
   Sheckter CC, 2016, J PLAST RECONSTR AES, V69, P1506, DOI 10.1016/j.bjps.2016.06.024
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   White R, 2011, SUPPORTING EVIDENCE
NR 15
TC 1
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2019
VL 46
IS 4
BP 337
EP 342
DI 10.1097/WON.0000000000000539
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA IQ4KC
UT WOS:000480718600015
PM 31274868
DA 2026-07-24
ER

PT J
AU Reider, KE
AF Reider, Kersten E.
TI Fistula Isolation and the Use of Negative Pressure to Promote Wound
   Healing A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Collapsible fistula isolation device; Enteroatmospheric fistula; Fistula
   isolation; Negative-pressure wound therapy
ID ENTEROATMOSPHERIC FISTULAS
AB BACKGROUND: A 54-year-old morbidly obese woman with a small bowel obstruction and large ventral hernia was admitted to hospital. She underwent an exploratory laparotomy, lysis of adhesions, and ventral hernia repair with mesh placement. She subsequently developed an enteroatmospheric fistula; several months of hospital care was required to effectively manage the wound and contain effluent from the fistula.
   METHODS: Several approaches were used to manage output from the fistula during her hospital course. She was initially discharged to a skilled nursing facility where a fistula management pouch was used for several months to encompass the wound and contain effluent, but this method ultimately proved ineffective. The fistula was then isolated using a collapsible enteroatmospheric fistula isolation device and an ostomy appliance to contain effluent.
   CONCLUSION: The application of the collapsible enteroatmospheric fistula isolation and effluent containment devices in conjunction with negative-pressure wound therapy produced positive patient outcomes; it improved patient satisfaction with fistula management, promoted wound healing, and diminished cost.
C1 [Reider, Kersten E.] Reading Hlth Syst, 6th Ave & Spruce St, W Reading, PA 19611 USA.
RP Reider, KE (通讯作者)，Reading Hlth Syst, 6th Ave & Spruce St, W Reading, PA 19611 USA.
EM Kersten.reider@readinghealth.org
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   Brindle CT, 2009, J WOUND OSTOMY CONT, V36, P396, DOI 10.1097/WON.0b013e3181aaf2b0
   Heineman JT, 2015, J AM COLL SURGEONS, V221, pE7, DOI 10.1016/j.jamcollsurg.2015.04.015
   Hoeflok J, 2009, J WOUND OSTOMY CONT, V43, P607
   Majercik S, 2012, NUTR CLIN PRACT, V27, P507, DOI 10.1177/0884533612444541
   Schecter WP, 2009, ACS, V209, P484, DOI DOI 10.1016/J.JAMC0LLSURG.2009.05.025]
   Terzi C, 2014, INT WOUND J, V11, P17, DOI 10.1111/iwj.12288
   Timmons J, 2014, INT WOUND J, V11, P723, DOI 10.1111/iwj.12038
NR 8
TC 4
Z9 5
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2017
VL 44
IS 3
BP 293
EP 298
DI 10.1097/WON.0000000000000329
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EU3JM
UT WOS:000400925300013
PM 28472817
DA 2026-07-24
ER

PT J
AU Ryan, SP
   Pugliano, V
AF Ryan, S. P.
   Pugliano, V.
TI CONTROVERSIES IN INITIAL MANAGEMENT OF OPEN FRACTURES
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE Open fracture; antibiotic; negative pressure wound therapy
ID OPEN TIBIAL FRACTURES; PRESSURE WOUND THERAPY; LONG-BONE FRACTURES;
   SURGICAL DEBRIDEMENT; DEEP INFECTION; TIME-DELAY; COVERAGE; LEG;
   COMPLICATIONS; ANTIBIOTICS
AB Background: Treatment of open fractures continues to be a challenge for orthopedic and trauma surgeons, and early treatment recommendations, which persist in the literature for decades, often do not have supporting data.
   Methods: This is a critical review of the literature surrounding controversies in the initial management of open fractures. It also focuses on the utility of negative pressure dressings in the care of associated complex wounds. Studies were selected based on their relevance to the treatment of open fractures.
   Results: A total of 40 studies were included. The following topics were critically discussed: timing of initial debridement, antibiotic coverage, utility of obtaining cultures, and timing of wound closure.
   Conclusion: The majority of open fractures require urgent, not emergent, irrigation and debridement. Antibiotics are essential in preventing infection in open fractures. Timely wound closure after all necrotic tissue has been debrided decreases complications in open fractures. Finally, negative pressure wound therapy has dramatically changed the care of associated complex wounds.
C1 [Ryan, S. P.; Pugliano, V.] Tufts Med Ctr, Dept Orthopaed Surg, Boston, MA 02111 USA.
C3 Tufts Medical Center
RP Ryan, SP (通讯作者)，Tufts Med Ctr, Dept Orthopaed Surg, Biewend 8th Floor,800 Washington St Box 306, Boston, MA 02111 USA.
EM sryan3@tuftsmedicalcenter.org
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   Skaggs DL, 2005, J BONE JOINT SURG AM, V87A, P8, DOI 10.2106/JBJS.C.01561
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   Stannard JP, 2010, INJURY, V41, P780, DOI 10.1016/j.injury.2009.08.011
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Webb LX, 2008, J ORTHOP TRAUMA, V22, pS135, DOI 10.1097/BOT.0b013e31818956ce
   Webb LX, 2007, J BONE JOINT SURG AM, V89A, P923, DOI 10.2106/JBJS.F.00776
   Werner CML, 2008, J AM ACAD ORTHOP SUR, V16, P369, DOI 10.5435/00124635-200807000-00002
NR 40
TC 30
Z9 33
U1 0
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2014
VL 103
IS 2
BP 132
EP 137
DI 10.1177/1457496913519773
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AJ3NL
UT WOS:000337573400008
PM 24737846
DA 2026-07-24
ER

PT J
AU Dorneden, A
   Olson, G
   Boyd, N
AF Dorneden, Ashley
   Olson, Garth
   Boyd, Nathan
TI Negative Pressure Wound Therapy (Wound VAC) in the Treatment of Chylous
   Fistula After Neck Dissection
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE chylous fistula; chyle leak; neck dissection; postoperative
   complications; wound vac therapy
ID ASSISTED CLOSURE; MANAGEMENT; HEAD; OCTREOTIDE
AB Objectives: Cervical chylous fistula is an uncommon but potentially severe occurrence associated with neck surgery. Methods for treating this problem have inconsistent efficacy and may result in lengthy hospital stays. Negative pressure wound therapy (NPWT) is a highly effective tool in the management of complex wounds. We report 3 cases where NPWT was successfully used to treat chylous fistulas following neck dissection.
   Methods: This is a retrospective chart review of 3 patients who developed chylous fistulas after neck dissection and were successfully treated with NPWT.
   Results: Chylous ouput ceased within 2 to 8 days of proper wound VAC placement. Hospital stays ranged from 6 to 47 days. Patients received altered diets, including TPN for I patient with high-flow output and nil-per-os (NPO) or clear liquids for the others. Patients received octreotide throughout their hospitalization.
   Conclusion: NPWT shows potential as a treatment option for both high-volume and low-volume chylous fistulas following neck dissection.
C1 [Dorneden, Ashley; Olson, Garth; Boyd, Nathan] Univ New Mexico, Dept Surg, Otolaryngol Div, Sch Med, MSC 10 5610,1 Univ New Mexico, Albuquerque, NM 87131 USA.
C3 University of New Mexico
RP Dorneden, A (通讯作者)，Univ New Mexico, Dept Surg, Otolaryngol Div, Sch Med, MSC 10 5610,1 Univ New Mexico, Albuquerque, NM 87131 USA.
EM adorneden@gmail.com
OI Dorneden, Ashley/0000-0002-4039-2032; Olson, Garth/0000-0001-5789-0014
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NR 19
TC 11
Z9 14
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JUN
PY 2019
VL 128
IS 6
BP 569
EP 574
DI 10.1177/0003489419827037
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA IC0QF
UT WOS:000470664200012
PM 30693805
DA 2026-07-24
ER

PT J
AU Poon, H
   Le Cocq, H
   Mountain, AJ
   Sargeant, ID
AF Poon, Henrietta
   Le Cocq, Heather
   Mountain, Alistair J.
   Sargeant, Ian D.
TI Dermal Fenestration With Negative Pressure Wound Therapy: A Technique
   for Managing Soft Tissue Injuries Associated With High-Energy Complex
   Foot Fractures
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE blister; calcaneum; compartment syndrome; dermis; fasciotomy; pilon
   fracture
ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; BLISTERS; COMPLICATIONS;
   EXPLOSIONS; MANAGEMENT; PATTERNS
AB Military casualties can sustain complex foot fractures from blast incidents. This frequently involves the calcaneum and is commonly associated with mid-foot fracture dislocations. The foot is at risk of both compartment syndrome and the development of fracture blisters after such injuries. The amount of energy transfer and the environment in which the injury was sustained also predispose patients to potential skin necrosis and deep infection. Decompression of the compartments is a part of accepted practice in civilian trauma to reduce the risk of complications associated with significant soft tissue swelling. The traditional methods of foot fasciotomy, however, are not without significant complications. We report a simple technique of dermal fenestration combined with the use of negative pressure wound therapy, which aims to preserve the skin integrity of the foot without resorting to formal fasciotomy. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Poon, Henrietta; Mountain, Alistair J.; Sargeant, Ian D.] Royal Ctr Def Med, Birmingham, W Midlands, England.
   [Le Cocq, Heather] Leeds Teaching Hosp Natl Hlth Serv Trust, Birmingham B15 2WB, W Midlands, England.
C3 Royal Centre for Defence Medicine
RP Poon, H (通讯作者)，Leeds Teaching Hosp Natl Hlth Serv Trust, Royal Ctr Def Med, Birmingham B15 2WB, W Midlands, England.
EM hpoonie@doctors.net.uk
CR Champion HR, 2009, J TRAUMA, V66, P1468, DOI 10.1097/TA.0b013e3181a27e7f
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NR 28
TC 11
Z9 14
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 161
EP 165
DI 10.1053/j.jfas.2015.08.014
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200036
PM 26443232
DA 2026-07-24
ER

PT J
AU Jing, G
   Wang, LL
AF Jing, Gang
   Wang, LinLin
TI Repairing Exposed Tendon Wounds with Absorbable Gelatin Sponges and
   Autologous Split-Thickness Skin Grafts: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE absorbable gelatin sponge; debridement; necrosis; negative-pressure
   wound therapy; repair; skin grafting; tendon exposure; wounds
ID FIBROBLAST-GROWTH-FACTOR; ARTIFICIAL SKIN; RECONSTRUCTION; EFFICACY;
   RELEASE; DERMIS
AB Conventional flap repair surgery has several drawbacks, including operational complexity, donor site damage, and high risk. In this case series, the authors explored an alternative approach for repairing exposed tendon wounds caused by trauma using absorbable gelatin sponges (AGSs) and autologous thigh skin grafts. This report presents two cases of lower-extremity skin necrosis with tendon exposure following wound debridement. The treatment approach involved early debridement, negative-pressure wound therapy, and wound irrigation with 0.9% sodium chloride. Upon achieving controlled wound infection, AGSs were applied to the exposed tendon to prevent degeneration and promote wound healing. Subsequently, areas where granulation tissue failed to cover the tendon were repaired using AGSs and 0.25-mm-thick autologous mesh skin grafts harvested from the thigh. Complete wound healing was achieved in both cases, on the 20th and 12th day after skin grafting, respectively. The proposed method proved successful in repairing exposed tendon wounds, effectively preventing infection and necrosis.
C1 [Jing, Gang] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Burn & Skin Repair Surg, Hainan, Peoples R China.
   [Wang, LinLin] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Hainan, Peoples R China.
C3 Hainan Medical University; Hainan Medical University
RP Jing, G (通讯作者)，Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Burn & Skin Repair Surg, Hainan, Peoples R China.
EM jg851212@126.com; 115212944@qq.com
OI Jing, gang/0009-0004-9514-6439
FU Hainan Provincial Natural Science Foundation of China [822QN449];
   National Natural Science Fund Cultivating 530 Project of Hainan General
   Hospital [2021QNXM02]; Courtyard's Level Program of Hainan General
   Hospital [QN202012]
FX This work was funded by the Hainan Provincial Natural Science Foundation
   of China (822QN449), the National Natural Science Fund Cultivating 530
   Project of Hainan General Hospital (2021QNXM02), and the Courtyard's
   Level Program of Hainan General Hospital (QN202012).
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   Zhu CT, 2019, J CELL BIOCHEM, V120, P12182, DOI 10.1002/jcb.28588
NR 19
TC 0
Z9 0
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUL
PY 2024
VL 37
IS 7
BP 6
EP 6
DI 10.1097/ASW.0000000000000166
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA WC3W1
UT WOS:001252639900009
PM 38899825
OA hybrid
DA 2026-07-24
ER

PT J
AU Boo, YJ
   Nam, MH
   Lee, EH
   Lee, KC
AF Boo, Yoon Jung
   Nam, Myung Hyun
   Lee, Eun Hee
   Lee, Kuang Chul
TI Cyclic neutropenia with a novel gene mutation presenting with a
   necrotizing soft tissue infection and severe sepsis: case report
SO BMC PEDIATRICS
LA English
DT Article
DE Cyclic neutropenia; Soft tissue infection; Necrotizing;
   Negative-pressure wound therapy
ID FASCIITIS
AB Background: Cyclic neutropenia is a rare disease. We report a 31-month-old girl with congenital cyclic neutropenia with a novel mutation in the ELANE gene who developed an acute necrotizing soft-tissue infection on her left axillary legion.
   Case presentation: A 31-month-old girl was admitted to our pediatric emergency room because of a necrotizing soft tissue infection of the left axillary area. The infection progressed rapidly and resulted in septic shock. Despite a medical treatment and surgical debridement, the sepsis was not controlled, and severe inflammation developed. After applying of negative-pressure wound therapy, her clinical symptoms improved. Finally, she was diagnosed with cyclic neutropenia with a novel genetic mutation. One month after admission, she was discharged with a completely recovered wound and no need for skin grafting.
   Conclusion: Both adequate medical treatment and effective control of the source of infection are critically important to reduce morbidity in such complex cases of necrotizing fasciitis as appeared in an immunocompromised pediatric patient.
C1 [Boo, Yoon Jung] Korea Univ, Div Pediat Surg, Dept Surg, Coll Med, Seoul 136705, South Korea.
   [Nam, Myung Hyun] Korea Univ, Coll Med, Dept Lab Med, Seoul 136705, South Korea.
   [Lee, Eun Hee; Lee, Kuang Chul] Korea Univ, Coll Med, Dept Pediat, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine)
RP Boo, YJ (通讯作者)，Korea Univ, Div Pediat Surg, Dept Surg, Coll Med, 73 Inchonro, Seoul 136705, South Korea.
EM drboo@korea.ac.kr; myunghyun.nam@gmail.com
OI Nam, Myung-Hyun/0000-0002-8737-6902
CR Adzhubei IA, 2010, NAT METHODS, V7, P248, DOI 10.1038/nmeth0410-248
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   Dale DC, 2011, CANCER TREAT RES, V157, P97, DOI 10.1007/978-1-4419-7073-2_6
   Horwitz MS, 2013, HEMATOL ONCOL CLIN N, V27, P19, DOI 10.1016/j.hoc.2012.10.004
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   Palmer SE, 1996, AM J MED GENET, V66, P413, DOI 10.1002/(SICI)1096-8628(19961230)66:4<413::AID-AJMG5>3.0.CO;2-L
   Pandey A, 2008, J Wound Care, V17, P5
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
   Tsai YH, 2012, INT J INFECT DIS, V16, pE159, DOI 10.1016/j.ijid.2011.11.001
NR 10
TC 8
Z9 12
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD APR 2
PY 2015
VL 15
AR 34
DI 10.1186/s12887-015-0352-5
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA CE9UD
UT WOS:000352188000001
PM 25880377
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ciloglu, S
   Duran, A
   Pekcan, SY
   Buyukdogan, H
AF Ciloglu, Sinem
   Duran, Alpay
   Pekcan, Sirin Yasar
   Buyukdogan, Hasan
TI Leg ulcer in a patient with Rothmund-Thomson syndrome
SO SPRINGERPLUS
LA English
DT Article
ID THERAPY
AB Background: Rothmund-Thomson syndrome is a rare genetic condition exhibiting some dermatological, craniofacial, ophthalmological, and central nervous system abnormalities.
   Case description: A 51-year-old male patient, diagnosed with Rothmund-Thomson syndrome, attended to our outpatient clinic with complaint of unhealing wound in lower part of his left leg. Over this period, he had received various local therapies such as creams, wound dressings and hyperbaric oxygen therapy but no progress could be achieved. The wound gradually enlarged. Negative pressure wound therapy was applied at - 125 mmHg for 20 days. Wound was finally covered with split-thickness skin graft.
   Discussion and evaluation: There is only one case of Rothmund-Thomson syndrome with leg ulcer reported in the literature. However, complete closure has not been achieved with non-surgical therapies in this case. Therefore we performed negative pressure wound therapy followed by skin grafting.
   Conclusions: It is useful to treat therapy resistant wounds in Rothmund-Thomson syndrome by negative pressure, which can preserve residual vital tissue, and help clear away necrotizing tissue effectively and close the wound promptly.
C1 [Ciloglu, Sinem; Buyukdogan, Hasan] Haydarpasa Numune Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Duran, Alpay] Sinop Ataturk State Hosp, Dept Plast Reconstruct & Aesthet Surg, Sinop, Turkey.
   [Pekcan, Sirin Yasar] Haydarpasa Numune Training & Res Hosp, Dept Dermatol, Istanbul, Turkey.
C3 Istanbul Haydarpasa Sultan Abdulhamid Training & Research Hospital;
   Istanbul Haydarpasa Numune Training & Research Hospital; Sinop
   University; Sinop Ataturk State Hospital; Istanbul Haydarpasa Numune
   Training & Research Hospital; Istanbul Haydarpasa Sultan Abdulhamid
   Training & Research Hospital
RP Duran, A (通讯作者)，Sinop Ataturk State Hosp, Dept Plast Reconstruct & Aesthet Surg, Sinop, Turkey.
EM dr.alpayduran@hotmail.com
RI ; Eroglu, Sinem/AAY-7996-2021; DURAN, ALPAY/IZP-7041-2023
OI Buyukdogan, Hasan/0000-0002-8508-1414; DURAN, ALPAY/0000-0003-0489-2088
CR Altunay I, 2010, INT WOUND J, V7, P531, DOI 10.1111/j.1742-481X.2010.00734.x
   Larizza L, 2010, ORPHANET J RARE DIS, V5, DOI 10.1186/1750-1172-5-2
   Seidel D, 2014, TRIALS, V15, DOI 10.1186/1745-6215-15-334
   Wang LL, 2001, AM J MED GENET, V102, P11, DOI 10.1002/1096-8628(20010722)102:1<11::AID-AJMG1413>3.0.CO;2-A
   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 5
TC 3
Z9 3
U1 0
U2 5
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD OCT 5
PY 2015
VL 4
AR 572
DI 10.1186/s40064-015-1374-z
PG 3
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CS7AA
UT WOS:000362234700003
PM 26543707
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU de la Fuente, PZ
   Suescún, FC
   Larrán, RG
   Herrera, RS
   Fernández, GP
AF de la Fuente, Patricia Zorrilla
   Suescun, Federico Castillo
   Larran, Rodrigo Gonzalez
   Herrera, Ramon Sancibrian
   Fernandez, Galo Peralta
TI A novel dynamic abdominal wall traction system for open abdomen:
   preclinical evaluation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Open abdomen (OA); Dynatract (R); Negative pressure wound therapy
   (NPWT); Temporary abdominal closure (TAC); Abdominal compartment
   syndrome (ACS); Abdominal closure techniques
ID PRESSURE WOUND THERAPY; CLOSURE TECHNIQUES; FASCIAL CLOSURE; MANAGEMENT
AB Aim: This study evaluates the efficacy and safety of Dynatract (R), a novel device designed to facilitate early primary closure and prevent aponeurotic retraction in patients with an open abdomen (OA). Method: A preclinical trial was conducted using a porcine model, comparing two groups: one treated solely with AbTheraTM Negative Pressure Wound Therapy (NPWT), and another combining AbTheraTM NPWT with Dynatract (R). The primary endpoint was to evaluate the distance between fascial edges, with secondary measures including the force required to achieve abdominal closure and overall closure success. Results: "The Dynatract (R) group showed a progressive reduction in fascial edge distance over time compared to the control group, with statistically significant differences observed at the caudal and midpoint positions (but not at the cranial position), as well as in the force required to achieve closure after 36 h. Complete fascial closure was achieved in all animals in both groups.
C1 [de la Fuente, Patricia Zorrilla; Suescun, Federico Castillo; Fernandez, Galo Peralta] Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Oria S-N, Santander 39011, Spain.
   [de la Fuente, Patricia Zorrilla; Herrera, Ramon Sancibrian] Univ Cantabria, Avda Castros S-N, Santander 39005, Spain.
   [Suescun, Federico Castillo] Hosp Univ Marques Valdecilla, Avda Valdecilla S-N, Santander 39008, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Hospital Universitario Marques de Valdecilla (HUMV)
RP de la Fuente, PZ (通讯作者)，Inst Invest Sanitaria Valdecilla IDIVAL, Avda Cardenal Herrera Oria S-N, Santander 39011, Spain.
EM patricia.zorrilla@idival.org; fcastillo7@hotmail.com;
   rodrigoglarran@gmail.com; ramon.sancibrian@unican.es;
   galo.peralta@idival.org
RI ; Sancibrian, Ramon/J-8369-2016
OI Zorrilla, Patricia/0000-0002-8910-8469; Castillo Suescun,
   Federico/0000-0002-5092-8830; 
FU Instituto de Investigacio n Sanitaria Valdecilla (IDIVAL) [DTEC23/01]
FX Assistance with the study: none. This work has been made possible by a
   research grant (DTEC23/01) from Instituto de Investigacio n Sanitaria
   Valdecilla (IDIVAL) .
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JAN
PY 2026
VL 57
IS 1
AR 112849
DI 10.1016/j.injury.2025.112849
EA DEC 2025
PG 10
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA AM4DU
UT WOS:001651570600001
PM 41233200
OA Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Goldberg, B
   Elazar, A
   Glatt, A
   Camins, B
   Datta, R
   Takahashi, H
   Seitelman, E
AF Goldberg, Braden
   Elazar, Amit
   Glatt, Aaron
   Camins, Bernard
   Datta, Rajiv
   Takahashi, Hideo
   Seitelman, Eric
TI Perioperative Interventions to Reduce Surgical Site Infections: A Review
SO AORN JOURNAL
LA English
DT Review
DE surgical site infection (SSI); preoperative skin antisepsis;
   triclosan-coated suture (TCS); negative pressure wound therapy (NPWT);
   SSI prevention bundle
ID PRESSURE-WOUND-THERAPY; CARE-ASSOCIATED INFECTIONS; TRICLOSAN-COATED
   SUTURES; SKIN PREPARATION; POVIDONE-IODINE; PREVENTION; METAANALYSIS;
   CLOSURE; SURGERY; CHLORHEXIDINE
AB Surgical site infections (SSIs) contribute to increased health care costs and morbidity after procedures as well as prolonged length of stay. Perioperative personnel can use a variety of interventions to help reduce SSI incidence; however, all strategies are not effective for all patients (eg, antibiotic prophylaxis). Results of randomized controlled trials show that some SSI reduction strategies are generally effective, including preoperative skin antisepsis with an alcohol-based agent, closing surgical wounds with triclosan-coated suture, and applying a negative pressure wound therapy device to open and closed wounds. Study results do not show that irrigating clean wounds with crystalloid solutions containing antibiotics or routinely using plastic drapes with or without impregnated iodophor or silver nylon-impregnated dressings significantly reduces SSI incidence. Perioperative leaders should support the implementation of strategies to prevent SSIs and work with interdisciplinary team members to develop an SSI prevention bundle that will meet the needs of their patients.
C1 [Goldberg, Braden; Elazar, Amit; Datta, Rajiv; Seitelman, Eric] Mt Sinai South Nassau, Dept Surg, Oceanside, NY USA.
   [Glatt, Aaron] Mt Sinai South Nassau, Dept Med, Oceanside, NY USA.
   [Camins, Bernard] Mt Sinai Hosp, Med, New York, NY 10029 USA.
   [Takahashi, Hideo] Mt Sinai South Nassau, Dept Surg, Surg, Oceanside, NY 11570 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Takahashi, H (通讯作者)，Mt Sinai South Nassau, Dept Surg, Surg, Oceanside, NY 11570 USA.
EM hideo.takahashi@snch.org
RI ; Takahashi, Hideo/ABC-7429-2020
OI Goldberg, Braden/0009-0001-7091-3345; Camins,
   Bernard/0009-0006-6681-8093; 
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NR 60
TC 8
Z9 9
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-2092
EI 1878-0369
J9 AORN J
JI AORN J.
PD DEC
PY 2021
VL 114
IS 6
BP 587
EP 596
DI 10.1002/aorn.13564
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA XE9LA
UT WOS:000723701900015
PM 34846740
DA 2026-07-24
ER

PT J
AU Oshima, J
   Sasaki, K
   Aihara, Y
   Sasaki, M
   Shibuya, Y
   Inoue, Y
   Sekido, M
AF Oshima, Junya
   Sasaki, Kaoru
   Aihara, Yukiko
   Sasaki, Masahiro
   Shibuya, Yoichiro
   Inoue, Yoshiaki
   Sekido, Mitsuru
TI Combination of Three Different Negative Pressure Wound Therapy
   Applications and Free Flap for Open Elbow Joint Injury With Extensive
   Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID SKIN-GRAFT; DONOR SITE; MANAGEMENT
AB Negative pressure wound therapy (NPWT) for treating burns has a variety of therapeutic applications. Here, we present a case of a 53-year-old woman with self-inflicted burn injuries in whom NPWT was applied for three different purposes. The injured sites were the anterior neck, bilateral arms from the wrists upwards to the chest, and back. The left arm was deeply injured, and the elbow joint cavity was opened during treatment. First, NPWT was used for bridge to skin grafting on the entire upper left limb. Second, NPWT was used as a bolster dressing for the autograft after skin grafting was performed on the left arm except the open part of the joint. Third, NPWT over flap was used on the subsequent flap surgical site to address prolonged exudate from the flap margin. The exudate resolved after about a week. Good results were obtained using NPWT during the perioperative period of free flap transplantation for extensive open elbow joint burns. The use of NPWT is an effective option in the treatment of burns.
C1 [Oshima, Junya; Sasaki, Kaoru; Aihara, Yukiko; Sasaki, Masahiro; Shibuya, Yoichiro; Sekido, Mitsuru] Univ Tsukuba, Dept Plast & Reconstruct Surg, Tsukuba, Ibaraki, Japan.
   [Inoue, Yoshiaki] Univ Tsukuba, Dept Emergency & Crit Care Med, Tsukuba, Ibaraki, Japan.
C3 University of Tsukuba; University of Tsukuba
RP Oshima, J (通讯作者)，Univ Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058577, Japan.
EM ooshima-tuk@umin.ac.jp
OI Oshima, Junya/0000-0003-4814-0849
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NR 20
TC 2
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR 23
PY 2022
VL 43
IS 2
BP 479
EP 482
DI 10.1093/jbcr/irab228
EA DEC 2021
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA ZY5BX
UT WOS:000772602800028
PM 34865037
DA 2026-07-24
ER

PT J
AU Wang, CY
   Chiao, HY
   Chou, CY
   Wu, CJ
   Chang, CK
   Chu, TS
   Dai, NT
AF Wang, Chi-Yu
   Chiao, Hao-Yu
   Chou, Chang-Yi
   Wu, Chien-Ju
   Chang, Chun-Kai
   Chu, Tzi-Shiang
   Dai, Niann-Tzyy
TI Successful salvage and reconstruction of a finger threatened by
   Vibrio vulnificus necrotising fasciitis using fenestrated-type
   artificial dermis and three steps of topical negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Artificial dermis; Compartment syndrome; Necrotising fasciitis; NPWT;
   Vibrio vulnificus
ID SKIN-GRAFT; INFECTIONS
AB Vibrio vulnificus can cause severe skin and soft tissue infection (SSTI). The pathogen is an opportunistic marine bacterium that is likely to infect patients with chronic liver disease, patients in an immunocompromised state, and those in end-stage renal disease. V. vulnificus gains entry through soft tissues by direct penetration of a wound by infected marine organisms, such as raw oysters, shellfish and other seafood, or by exposing a wound to contaminated water. Despite its ease of entry, V. vulnificus necrotising fasciitis with compartment syndrome has rarely been described. We report a case of an elderly patient with end-stage renal disease undergoing haemodialysis, who developed necrotising fasciitis following infection by V. vulnificus through a puncture injury while cleaning fish. A successful salvage and reconstruction surgery was performed using fenestrated-type artificial dermis followed by negative pressure wound therapy. This case presents a reasonable treatment option for threatening V. vulnificus necrotising fasciitis with compartment syndrome.
C1 [Wang, Chi-Yu; Chiao, Hao-Yu; Chou, Chang-Yi; Wu, Chien-Ju; Chang, Chun-Kai; Chu, Tzi-Shiang; Dai, Niann-Tzyy] Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Natl Def Med Ctr, Taipei, Taiwan.
   [Wang, Chi-Yu] Kaohsiung Armed Forces Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Kaohsiung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University
RP Dai, NT (通讯作者)，Triserv Gen Hosp, Plast & Reconstruct Surg, Natl Def Med Ctr, 325 Cheng Kung Rd,Sec 2, Taipei 114, Taiwan.
EM niantzyydai@gmail.com
RI Chiao, Hao Yu/HLX-2170-2023
OI Chiao, Hao-Yu/0000-0001-5157-634X
CR Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   Centers for Disease Control and Prevention (CDC), 2005, MMWR Morb Mortal Wkly Rep, V54, P928
   Fraccalvieri M, 2012, INT WOUND J, V9, P214, DOI 10.1111/j.1742-481X.2011.00878.x
   Huang KC, 2008, J INFECTION, V57, P290, DOI 10.1016/j.jinf.2008.07.009
   Lim PL, 2005, ANN ACAD MED SINGAP, V34, P582
   Petkar KS, 2011, BURNS, V37, P925, DOI 10.1016/j.burns.2011.05.013
   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
   Waltzman JT, 2014, J BURN CARE RES, V35, pE338, DOI 10.1097/BCR.0000000000000009
   Wong CH, 2004, CRIT CARE MED, V32, P1535, DOI 10.1097/01.CCM.0000129486.35458.7D
   Wong Chin-Ho, 2005, Curr Opin Infect Dis, V18, P101, DOI 10.1097/01.qco.0000160896.74492.ea
NR 10
TC 4
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2017
VL 14
IS 5
BP 818
EP 822
DI 10.1111/iwj.12711
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FI3ME
UT WOS:000411865700012
PM 28052529
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Li, WR
   Chen, J
   Liu, YM
   Xie, ZF
   Fu, T
AF Li, Wanru
   Chen, Jun
   Liu, Yanming
   Xie, Zefeng
   Fu, Tao
TI Analysis of pathogenic bacteria of oral and maxillofacial space
   infection and the effect of vacuum sealing drainage treatment
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Oral and maxillofacial space infection; pathogen analysis; negative
   pressure drainage; clinical thera-peutic effect; inflammatory factors
ID PRESSURE WOUND THERAPY; MANAGEMENT
AB Objective: To investigate the pathogenic spectrum of oral and maxillofacial space infection and evaluate the clinical efficacy of vacuum sealing drainage (VSD) in its treatment. Methods: A retrospective analysis was performed on 118 patients with oral and maxillofacial space infection admitted to the Department of Stomatology, the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2021 to December 2023. All patients underwent pathogenic bacteria detection, and were divided into a conventional incision drainage group (n=72) and a VSD group (n=46) by treatment method. The clinical efficacy, recovery-related indicators, pain scores and serum inflammatory factor levels were compared between the two groups. Results: The most frequent infection sites were the masseteric, buccal and infraorbital spaces in turn. Staphylococcus aureus, Staphylococcus epidermidis and Klebsiella pneumoniae were the dominant pathogens. Compared with the conventional group, the VSD group showed a higher clinical effective rate, significantly shorter wound healing time, antibiotic course and hospital stay (all P < 0.05). Meanwhile, the VSD group had lower pain rating index (PRI), visual analogue scale (VAS), present pain intensity (PPI) scores, and lower serum levels of tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) (all P < 0.05). Conclusion: Oral and maxillofacial space infection is mainly caused by Gram-positive cocci. VSD can enhance clinical efficacy, alleviate pain, reduce inflammatory response, and shorten the duration of antibiotic use and hospitalization, which is worthy of clinical promotion.
C1 [Li, Wanru; Chen, Jun; Liu, Yanming; Xie, Zefeng; Fu, Tao] Zhejiang Univ, Affiliated Hosp 2, Dept Oral & Maxillofacial Surg, Sch Med, 88 Jiefang Rd, Hangzhou 31000, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Fu, T (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Dept Oral & Maxillofacial Surg, Sch Med, 88 Jiefang Rd, Hangzhou 31000, Zhejiang, Peoples R China.
EM futao13858083077@126.com
CR Alhudaithi AS, 2025, CRANIOMAX TRAUM REC, V18, DOI 10.3390/cmtr18030031
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NR 27
TC 0
Z9 0
U1 3
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2026
VL 18
IS 2
BP 1541
EP 1552
DI 10.62347/RJFS1052
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EU8PH
UT WOS:001710284600011
PM 41868901
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Li, Y
   Li, W
   Dou, LR
   Ding, HZ
AF Li, Yang
   Li, Wei
   Dou, Lianrong
   Ding, Hongzhi
TI Morel-Lavallée lesion: A case report and literature review
SO MEDICINE
LA English
DT Article
DE closed degloving injury; Morel-Lavall & eacute;e lesion; sarcoma; soft
   tissue; trauma
ID MOREL-LAVALLEE LESIONS; DEGLOVING INJURIES; MANAGEMENT; DIAGNOSIS;
   THIGH; KNEE
AB Rationale:Morel-Lavall & eacute;e lesions (MLLs) represent closed degloving injuries resulting from traumatic separation of skin/subcutaneous tissue from deep fascia. While typically associated with high-energy trauma, diagnosis becomes challenging in cases with occult trauma, complex comorbidities, or tumor-mimicking imaging features. This case report aims to highlight the diagnostic challenges and management strategy of MLL in a patient with a history of malignancy and anticoagulant therapy, underscoring the importance of pathological confirmation in atypical presentations.Patient concerns:A 56-year-old woman was diagnosed with: MLL, hypertension, type II diabetes mellitus, status post meningioma resection, status post hysterectomy for cervical cancer, and status post inferior vena cava filter placement. Hip magnetic resonance imaging revealed soft tissue infiltration. Following comprehensive history review and pathological evaluation, malignancy was excluded, confirming the diagnosis of MLL.Diagnoses:Morel-Lavall & eacute;e lesion.Interventions:Initial management included intravenous antibiotic therapy (cefazolin, 1 g twice daily) and percutaneous aspiration of fluid for pathological examination. Following exclusion of malignancy, the patient underwent debridement of peritrochanteric soft tissues with subsequent application of vacuum sealing drainage.Outcomes:The patient showed significant clinical improvement following percutaneous aspiration and antibiotic therapy. After surgical debridement and vacuum sealing drainage application, the wound healed completely without recurrence. She was discharged after an additional week of postoperative antibiotics and supportive care, with no complications at 1-month follow-up.Lessons:MLL require differential diagnosis from soft tissue neoplasms, particularly in patients with a history of malignancy. Anticoagulation may predispose to occult MLL development. Consequently, pathological examination is essential to establish a definitive diagnosis of MLL.
C1 [Li, Yang; Li, Wei; Dou, Lianrong; Ding, Hongzhi] Shanghai Jiao Tong Univ, Songjiang Hosp, Sch Med, Dept Orthopaed Surg, 746 Zhongshan Middle Rd, Shanghai 201600, Peoples R China.
C3 Shanghai Jiao Tong University
RP Ding, HZ (通讯作者)，Shanghai Jiao Tong Univ, Songjiang Hosp, Sch Med, Dept Orthopaed Surg, 746 Zhongshan Middle Rd, Shanghai 201600, Peoples R China.
EM fishbone@vip.sina.com; fishbone@vip.sina.com; dd_dlr@sina.com;
   dinghongzhi121314@163.com
CR Amaravathi U, 2023, J EMERG MED, V64, P67, DOI 10.1016/j.jemermed.2022.10.012
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NR 38
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 16
PY 2026
VL 105
IS 3
AR e47083
DI 10.1097/MD.0000000000047083
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC1LJ
UT WOS:001679911700003
PM 41560018
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, TT
   Jia, RF
   Zheng, XY
   Ma, CW
   Chen, X
   Cao, MC
   He, XY
   Wang, YF
AF Wang, TingTing
   Jia, RuFu
   Zheng, XinYing
   Ma, ChunWei
   Chen, Xi
   Cao, MingCong
   He, XiaoYang
   Wang, YaFei
TI Effect of Music Therapy Integrated with ORTCC Model-Based Nursing on
   Patients Undergoing Vacuum Sealing Drainage in Surgical Settings
SO NOISE & HEALTH
LA English
DT Article
DE music therapy; pain; quality of life; surgical wound
ID PRESSURE WOUND THERAPY
AB Objective: This study aimed to analyse the effects of music therapy combined with the Objective-Rules-Training-Check-Culture (ORTCC) model-based nursing in patients undergoing vacuum sealing drainage (VSD) for surgical wounds. Methods: In this retrospective cohort study, clinical data of 132 patients from Cangzhou Central Hospital receiving VSD for hand and foot surgeries between June 2022 and June 2023 were retrospectively analysed. In accordance with actual nursing protocols, participants were allocated to either the ORTCC group (n = 67), receiving systematic ORTCC model-based nursing, or the combination group (n = 65), receiving additional music therapy alongside ORTCC nursing. Outcomes included fear of disease progression [Fear of Progression Questionnaire-Short Form (FoP-Q-SF)], mood states [Brief Profile of Mood States (BPOMS)], quality of life [Generic Quality of Life Inventory-74 (GQOLI-74)], compliance rates, satisfaction scores and complication incidence. Results: No significant intergroup differences were observed in wound healing time, pain scores and complication rates (P > 0.05). Both groups exhibited reduced FoP-Q-SF and BPOMS scores after care compared with baseline, with significantly lower scores in the combination group than in the ORTCC group (P < 0.05). All GQOLI-74 domain scores increased after care in both groups, but they were significantly higher in the combination group (P < 0.05). The combination group demonstrated superior nursing compliance rates and satisfaction scores (P < 0.05). Conclusion: Surgical patients undergoing VSD and receiving combined music therapy and ORTCC model-based nursing exhibited significantly reduced fear of disease progression, mood improvement, enhanced quality of life and superior compliance and satisfaction, though no additional advantages were observed in physiological wound healing.
C1 [Wang, TingTing] Cangzhou Cent Hosp, Neuropsychol Dept Cognit Disorders, Cangzhou, Hebei, Peoples R China.
   [Wang, TingTing] Cangzhou Cent Hosp, Parkinsons Motor Disorders Dept, Cangzhou, Hebei, Peoples R China.
   [Jia, RuFu; Zheng, XinYing; Wang, YaFei] Cangzhou Cent Hosp, Nursing Dept, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
   [Ma, ChunWei] Yanshan Cty Peoples Hosp, Surg Dept, Cangzhou, Hebei, Peoples R China.
   [Chen, Xi] Cangzhou Cent Hosp, Orthoped Dept, Cangzhou, Hebei, Peoples R China.
   [Cao, MingCong] Cangzhou Cent Hosp, Ophthalmol Dept, Cangzhou, Hebei, Peoples R China.
   [He, XiaoYang] Cangzhou Cent Hosp, Surg Dept, Cangzhou, Hebei, Peoples R China.
RP Wang, YF (通讯作者)，Cangzhou Cent Hosp, Nursing Dept, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
EM dawsonhitler@163.com
RI /T-8558-2019; Ma, Chunwei/JWP-3755-2024
FU  [222106100]
FX Application of nursing intervention based on ORTCC model in
   perioperative patients undergoing surgical negative pressure closure and
   drainage (222106100).
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NR 22
TC 0
Z9 0
U1 1
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1463-1741
EI 1998-4030
J9 NOISE HEALTH
JI Noise Health
PD NOV-DEC
PY 2025
VL 27
IS 129
BP 879
EP 886
DI 10.4103/nah.nah_138_25
PG 8
WC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
GA AO7NZ
UT WOS:001653155000003
PM 41482917
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, LG
   Yang, YG
   Yang, XM
   Yang, TX
   Yang, YX
   Xie, JJ
AF Yang, Leigang
   Yang, Yungang
   Yang, Xiuming
   Yang, Tianxu
   Yang, Yuxuan
   Xie, Junjie
TI Free bone retention plus iliac bone grafting under phase I vacuum
   sealing drainage lavage for treatment of Gustilo type I, II, and IIIA
   open bone defects
SO BIOMEDICAL RESEARCH-INDIA
LA English
DT Article
DE Bone grafting; Open fracture; Bone defect; Treatment
ID FREE-FLAP TRANSPLANTATION; TIBIAL SHAFT FRACTURES; CATARACT-SURGERY;
   POVIDONE-IODINE; POSTTRAUMATIC OSTEOMYELITIS; MANAGEMENT; PRESSURE;
   THERAPY; ENDOPHTHALMITIS; CHLORHEXIDINE
AB This study aimed to investigate the treatment efficacy of free bone retention plus iliac bone grafting under phase I Vacuum Sealing Drainage (VAS) lavage for treatment of open bone defects. Thirty-six bone fractures were classified according to the Gustilo classification between January 2008 and April 2016. This study included 16 type I cases, 12 type II cases, and 8 type IIIA cases. Length of the longitudinal section of the damaged free crushed bone was 0.5 to 7.1 cm. There were 7 cases with sections <= 1 cm, 12 with sections 2 to 3 cm, 11 with sections 3 to 5 cm, and 6 with sections>5 cm. The rinse protocol comprised 3000 ml/d of saline for 3 days for Gustilo type I fractures, 6000 ml/day of saline for 5 days for Gustilo type II fractures, and 9000 ml/d of saline for 7 days for Gustilo type IIIA fractures. Fifty ml of Anerdian (type III, diluted 10 fold) was added by VSD treatment (closed negative-pressure lavage). Callus formation was seen within 3.5 months after surgery, with osseous union at an average of 6.5 months. The wound healed well in 35 cases. In l case, the patient developed superficial cellulitis near the screw path, which resolved after removing the external fixation device. There was no internal fixation loosening, breakage, or exposure. Non-union and osteomyelitis were not seen. This method could be effective to prevent infection, osteomyelitis, delayed union, and non-union.
C1 [Yang, Leigang; Xie, Junjie] Xianyang Ctr Hosp, Dept Orthopaed, Xianyang, Peoples R China.
   [Yang, Yungang; Yang, Xiuming; Yang, Tianxu; Yang, Yuxuan] Xianyang Yangsa Hosp, Dept Pain, Xianyang, Peoples R China.
RP Yang, YG (通讯作者)，Xianyang Yangsa Hosp, Dept Pain, Xianyang, Peoples R China.
RI Junjie, Xie/AHD-4060-2022; Yuxuan, Yang/LBI-0448-2024
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NR 35
TC 1
Z9 1
U1 1
U2 4
PU ALLIED ACAD
PI LONDON
PA 40 BLOOMSBURY WAY, LOWER GROUND FLR, LONDON, WC1A 2SE, ENGLAND
SN 0970-938X
EI 0976-1683
J9 BIOMED RES-INDIA
JI Biomed. Res.-India
PY 2017
VL 28
IS 6
BP 2456
EP 2461
PG 6
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA EX7SI
UT WOS:000403448200014
DA 2026-07-24
ER

PT J
AU Yuan, Y
   Zhong, X
   Zhang, J
   Shen, CM
   Huang, GX
   Zhang, JC
   Wang, K
   Xu, M
   Shao, S
   Yang, J
   Qian, D
AF Yuan, Yuan
   Zhong, Xian
   Zhang, Jian
   Shen, Chunming
   Huang, Guoxin
   Zhang, Jianchao
   Wang, Ke
   Xu, Ming
   Shao, Sheng
   Yang, Jun
   Qian, Da
TI Artificial dermis combined with split-thickness skin autograft in the
   treatment of hand thermal compression wounds: a single center
   case-control study
SO FRONTIERS IN SURGERY
LA English
DT Article
DE artificial dermis; thermal compression wound; wound repair; graft;
   vacuum sealing drainage technology
AB Objective: To explore the clinical effect of artificial dermis combined with split-thickness skin autograft in treating hand thermal compression wounds. Methods: Forty-two patients in our hospital from January 2016 to October 2022 with thermal compression wounds were divided into two groups. The survival rate of autologous skin grafts seven days after skin grafting, the number of operations, total hospital stay, total hospitalization cost, and bacterial culture results of secretions were recorded. The visual analog scale was used to evaluate the wound pain. The condition of skin graft rupture was recorded and the scar status of the donor site was evaluated by the Vancouver Scar Scale. Results: It showed combination of artificial dermis, split-thickness skin autograft, and vacuum sealing drainage improves the treatment of hand thermal compression wounds by enhancing the survival rate of skin grafting (95.24% > 66.67%), reducing the number of operations (P < 0.001), relieving wound pain (P < 0.001), effectively controlling wound infection (4.76% < 9.52%), and reducing the skin graft rupture rate after surgery (4.8% < 28.6%). There was no evident scar hyperplasia in the donor (P = 0.003) and skin graft areas (P < 0.001), which had a good recovery of hand function (P = 0.037); however, this treatment strategy may prolong the hospital stay (P = 0.030) and increase the total hospitalization cost (P = 0.030). Conclusion: The composite transplantation of artificial dermis and split-thickness skin combined with the VSD significantly improves treatment and aesthetic outcomes in patients with thermal compression wounds to the hand, which is worth promoting and applying in clinical practice.
C1 [Yuan, Yuan; Zhong, Xian; Zhang, Jian; Shen, Chunming; Zhang, Jianchao; Wang, Ke; Xu, Ming; Shao, Sheng; Qian, Da] Soochow Univ, Changshu Peoples Hosp 1, Changshu Hosp, Dept Burn & Plast Surg Hand Surg, Changshu, Peoples R China.
   [Huang, Guoxin] Hubei Univ Med, Xiangyang Peoples Hosp 1, Based Med Ctr, Dept Evidence, Xiangyang, Peoples R China.
   [Yang, Jun] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
C3 Soochow University - China; Hubei University of Medicine; Shanghai Jiao
   Tong University
RP Shao, S; Qian, D (通讯作者)，Soochow Univ, Changshu Peoples Hosp 1, Changshu Hosp, Dept Burn & Plast Surg Hand Surg, Changshu, Peoples R China.; Yang, J (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China.
EM ss-0603@163.com; yangj1580@sh9hospital.org.cn; drqianda@hotmail.com
RI Qian, Da/AFD-8353-2022; Zhang, Jian/MTA-2037-2025
OI Qian, Da/0000-0002-6062-8161; 
CR Ba T., 2004, Chin J Burns, V20, P1, DOI [10.3760/cma.j.issn.1009-2587.2004.02.023, DOI 10.3760/CMA.J.ISSN.1009-2587.2004.02.023]
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NR 33
TC 5
Z9 8
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD DEC 22
PY 2023
VL 10
AR 1304333
DI 10.3389/fsurg.2023.1304333
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HR1V3
UT WOS:001161150700001
PM 38186394
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhu, W
   Shu, ZQ
   Song, HP
AF Zhu, Wei
   Shu, Ziqin
   Song, Huapei
TI A rare case of a hard-to-heal ulcer caused by pulmonary Nocardia
   infection
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE debridement; nocardia; pulmonary infection; vacuum sealing drainage;
   wound; wound care; wound dressing; wound healing; hard-to-heal wound
ID WOUNDS
AB Nocardiosis is an acute purulent or granulomatous disease caused by Nocardia spp. infection that commonly invades the lungs and central nervous system. Hard -to -heal wounds caused by Nocardia spp. infection are rare. A 63 -year -old female patient underwent puncture biopsy due to a mass in the right lung. Subsequently, dermal ulceration occurred on her back at the biopsy site, with no improvement following treatment at multiple hospitals. After admission to our department, bacterial culture of sputum and discharge from the deep wound sinus revealed Nocardia asteroides infection. The treatment regimen was developed by a multidisciplinary team at our department. The patient underwent debridement and vacuum sealing drainage (VSD) and was administered imipenem. The wound was then sealed by local flap transfer. The patient was discharged from the hospital after the wound had healed and continued to take minocycline for 2 months. At 3 months post -discharge, the symptoms of lung infection had resolved. Nocardiosis mainly affects the lungs, and its clinical symptoms are similar to those of pulmonary tuberculosis. Nocardia infections can extend to the chest wall and form abscesses or cellulitis. For hard -to -heal wounds caused by Nocardia spp., local debridement combined with systemic anti -infective therapy should be applied. In this case study, the diagnosis of pulmonary and wound nocardiosis was confirmed based on clinical manifestations, imaging, aetiological investigation and pathology. The treatment regimen was debridement combined with VSD, as well as a full course of antibiotics. The optimal treatment regimen for hard -to -heal wounds caused by Nocardia spp. includes effective debridement combined with VSD and long -course antibiotic therapy, which can improve the cure rate.
C1 [Zhu, Wei; Song, Huapei] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Burn Res,State Key Lab Trauma Burn & Combine, Chongqing, Peoples R China.
C3 Army Medical University
RP Song, HP (通讯作者)，Army Med Univ, Third Mil Med Univ, Southwest Hosp, Inst Burn Res,State Key Lab Trauma Burn & Combine, Chongqing, Peoples R China.
EM shpmajor@hotmail.com
RI 朱, 玮/HKN-1733-2023
CR Acuner B, 2021, WOUND MANAG PREV, V67, P33, DOI 10.25270/wmp.2021.5.3339
   Derungs T, 2021, LANCET INFECT DIS, V21, pE334, DOI 10.1016/S1473-3099(20)30920-8
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   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
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NR 17
TC 0
Z9 0
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
IS 3
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QU9D3
UT WOS:001223490900006
DA 2026-07-24
ER

PT J
AU Wei, WL
   Wang, YJ
   Lin, QQ
   Lu, QF
AF Wei, Wenlin
   Wang, Yingjie
   Lin, Qiqing
   Lu, Qifeng
TI Application of nano-silver dressing combined with covered vacuum sealing
   drainage technology in cobra bite
SO MATERIALS EXPRESS
LA English
DT Article
DE Nano-Silver Dressing; VSD Technology; Cobra Bite
ID CHINESE COBRA; DNA; VENOM; NANOPARTICLES; NANOCLUSTERS; FLUORESCENCE
AB Limb swelling, pain, and coagulation dysfunction caused by cobra venom bite are difficult to treat, but the therapeutic effect is not ideal at present. Therefore, it is of great significance to find rapid and effective treatment. To explore the application value of nano-silver dressing combined with covered Vacuum sealing drainage (VSD) technology in Guangxi cobra bite. A total of 90 cases of cobra bite patients treated in our hospital from March to December 2019 were randomly divided into observation group and control group, with 45 cases in each group. The control group was treated with conventional treatment, and the observation group was treated with nanosilver dressing combined with covered VSD technology. The swelling degree of affected limbs, circumference measurement of bilateral limbs, pain degree of affected limbs, inflammatory factors, and coagulation function indexes were compared between the two groups. After treatment, the swelling degree and visual pain scale score of the observation group were lower than those of the control group. The peripheral diameter difference of bilateral limbs in the observation group was smaller than that in the control group 1 d and 3 d after treatment. The levels of inflammatory factors in the observation group were better than those in the control group. The coagulation function of the observation group after treatment was better than that of the control group. Conclusions: This study confirmed for the first time that nano-silver dressing combined with covered VSD technology can effectively eliminate local swelling, relieve pain, eliminate inflammatory reaction, improve blood circulation, and provide a new method for clinical treatment.
C1 [Wei, Wenlin; Wang, Yingjie; Lin, Qiqing; Lu, Qifeng] Youjiang Med Coll Nationalities, Dept Emergency, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.
C3 Youjiang Medical University for Nationalities
RP Wei, WL (通讯作者)，Youjiang Med Coll Nationalities, Dept Emergency, Affiliated Hosp, Baise 533000, Guangxi, Peoples R China.
FU Affiliated Hospital of Youjiang Medical College for Nationalities
FX This work was supported by the Affiliated Hospital of Youjiang Medical
   College for Nationalities.
CR Asadi H, 2020, INT J POLYM MATER PO, V69, P173, DOI 10.1080/00914037.2018.1552861
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NR 28
TC 1
Z9 1
U1 0
U2 11
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2158-5849
EI 2158-5857
J9 MATER EXPRESS
JI Mater. Express
PD MAR
PY 2021
VL 11
IS 3
BP 412
EP 418
DI 10.1166/mex.2021.1911
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA SR8AN
UT WOS:000661267700016
DA 2026-07-24
ER

PT J
AU Wang, J
   Zhang, H
   Wang, S
AF Wang, J.
   Zhang, H.
   Wang, S.
TI Application of vacuum sealing drainage in the treatment of internal
   fixation instrument exposure after early postoperative infection
SO MINERVA CHIRURGICA
LA English
DT Article
DE Drainage; Infection; Bone plates
ID POSTERIOR SPINAL-FUSION; ASSISTED WOUND CLOSURE; MANAGEMENT
AB Aim. This retrospective study aimed to investigate the effect of vacuum sealing drainage (VSD) in the management of fractured patients with internal fixation instrument exposure caused by early postoperative infection after open reduction and internal fixation (ORIF).
   Methods. Fourteen patients (11 men, 3 women, age range 9-63 years) with spinal and extremities fractures were enrolled in this study, including atlanto-axial fracture (N.=1), thoraco-lumbar fracture (N.=1), humerus fracture (N.=1), femoral fracture (N.=2), humerus fracture together with femoral fracture (N.=1), fracture of tibia and fibula (N.=3), L1 vertebral fracture together with tibia and fibula fracture (N.=2), Li vertebral fracture (N.=2) and L1 vertebral fracture complicated by type II diabetes (N.=1). Infections occurred at the surgical incisions 1-7 days after ORIF operation. Deep spread of the infection caused exposure of internal fixation device. All patients underwent local debridement with retention of internal fixation device. VSD foam dressings containing the drainage tube were placed into the wound, covering external fixation devices and fully eliminating the dead space of soft tissue to avoid effusion. Continuous drainage and VSD irrigation was performed for 24 h with regular replacement of VSD.
   Results. After 14-43 days of VSD treatment, internal fixation devices were covered by healthy granulation tissue and complete wound healing was achieved. During a postoperative follow-up period of between 2 to 52 months, physical examinations and imaging studies of all patients showed good functional recovery, no loosening of internal fixation devices, and no systemic or local infection.
   Conclusion. The use of VSD, while retaining the internal fixation device can be safe and effective with earlier wound healing and functional recovery.
C1 [Wang, J.; Zhang, H.; Wang, S.] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Gansu, Peoples R China.
   [Wang, S.] Orthoped Key Lab, Lanzhou, Gansu, Peoples R China.
C3 Lanzhou University
RP Wang, S (通讯作者)，Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730030, Gansu, Peoples R China.
EM k.alpha@163.com
CR Fassett DR, 2004, SEMIN SPINE SURG, V16, P174
   Guangyu H., 2010, J Spinal Surg, V8, P278
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NR 15
TC 18
Z9 39
U1 0
U2 6
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD FEB
PY 2015
VL 70
IS 1
BP 17
EP 22
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE7PS
UT WOS:000352034400003
PM 25389757
DA 2026-07-24
ER

PT J
AU Qu, WQ
   Wei, C
   Yu, L
   Deng, Y
   Fu, PF
   Kang, Z
   Zhu, SB
AF Qu, Wenqiang
   Wei, Chi
   Yu, Li
   Deng, Yu
   Fu, Panfeng
   Kang, Zhe
   Zhu, Shaobo
TI Three-Stage Masquelet Technique and One-Stage Reconstruction to Treat
   Foot and Ankle Tuberculosis
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE foot and ankle tuberculosis; 3-stage Masquelet technique; 1-stage
   reconstruction
ID VACUUM SEALING DRAINAGE; CEMENT SPACERS; BONE-CEMENT; LONG; OPERATION;
   OUTCOMES; DEFECTS
AB Background: The purpose of this article was to report the feasibility and effectiveness of 3-stage Masquelet technique and 1-stage operation for different stages of foot and ankle tuberculosis (TB). Methods: Ten consecutive patients with foot and ankle TB were retrospectively analyzed between January 2014 and December 2018. Five patients were treated with the 3-stage Masquelet technique, including thorough debridement with vacuum sealing drainage, implantation of antibiotic cement spacer, and subsequent reconstruction. Five patients were treated with a 1-stage reconstruction. The American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS) pain scores were recorded at the last follow-up. The follow-up was 30.3 +/- 17.8 months. Results: No reactivation of TB was observed in any patients. For the 3-stage operation group, 1 patient developed a distal tibia fracture. The duration of anti-TB therapy was 12.0 +/- 0.8 months. The AOFAS score increased from 39.5 +/- 9.9 preoperatively to 75.3 +/- 7.0 postoperatively (P < .05). The VAS pain score decreased from 6.3 +/- 1.9 to 1.5 +/- 1.3 (P < .05). For the 1-stage operation, 1 patient had wound necrosis. The duration of anti-TB therapy was 13.8 +/- 1.1 months. The AOFAS score increased from 51.8 +/- 15.0 to 81.8 +/- 6.3 (P < .05). The VAS pain score decreased from 5.4 +/- 1.1 to 1.0 +/- 0.7 (P < .05). Conclusions: Three-stage operation was effective for foot and ankle TB with stage IV, sinus tracts or other infections, and 1-stage reconstruction was effective for early-stage TBs.
C1 [Qu, Wenqiang; Wei, Chi; Yu, Li; Deng, Yu; Fu, Panfeng; Kang, Zhe; Zhu, Shaobo] Wuhan Univ, Dept Orthopaed Trauma & Microsurg, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Zhu, SB (通讯作者)，Wuhan Univ, Dept Orthopaed Trauma & Microsurg, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM zhushaobo2000@163.com
RI /I-7203-2018; fu, panfeng/N-8203-2018
OI Qu, Wenqiang/0000-0003-2810-2685
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NR 35
TC 6
Z9 9
U1 1
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2020
VL 41
IS 3
BP 331
EP 341
AR 1071100719890854
DI 10.1177/1071100719890854
EA DEC 2019
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KZ3LR
UT WOS:000501159300001
PM 31801382
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lv, ZM
   Yu, LL
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Yu, Lili
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Dermal regeneration template and vacuum sealing drainage for treatment
   of traumatic degloving injuries of upper extremity in a single-stage
   procedure
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE bone; tendon exposure; degloving injury; dermal regeneration template;
   vacuum sealing drainage
ID ARTIFICIAL DERMIS; RECONSTRUCTION; HAND; FOREARM; INTEGRA; SKIN;
   MANAGEMENT; DEFECTS
AB Background This study aimed to assess the efficacy and safety of a single-stage procedure using single-layer Pelnac and defatted avulsed skin for the management of degloving injuries of the forearm and hand. Methods This is a prospective study conducted from March 2013 to May 2017. A total of 15 consecutive patients with degloving injuries of the forearm and hand were treated with a single-stage procedure using single-layer Pelnac and defatted avulsed skin as a split-thickness skin graft. Post-operatively, scheduled follow-up was conducted. Results The overall 'take' rate of the Pelnac dermal template and the skin graft was 85-100%. No infections, haematoma or seroma were observed during hospitalization and after discharge. At the final follow-up, patients' subjective satisfaction with the aesthetic appearance of the grafted areas was, on average, 71.0 (SD 8.0, range 55-92). The Vancouver Scar Scale value was 2.1 (SD 1.8, range 1.0-5.5), representing a good result. The response of 'normal or near normal' to the sensory recovery was obtained for 13 patients and 'slight loss' for two patients. The average Disabilities of the Arm, Shoulder and Hand score was 21.2 (SD 13.5, range 0-53), and most patients (14/15) regained the ability to perform the daily activities without pain or restriction by tissue adhesion. Conclusion This single-stage procedure represents an effective technique for the management of degloving injuries of the forearm and hand and should be considered an alternative to other reconstructive procedures.
C1 [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui; Shen, Yong] Peoples Liberat Army, Hosp 252, Dept Hand & Foot Surg, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Ding, Wenyuan] Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zigiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
   [Yu, Lili] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Shen, Y (通讯作者)，Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zigiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM drshenyongspine@126.com
OI Ding, Wenyuan/0000-0002-7257-4316
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NR 24
TC 7
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD JUL
PY 2019
VL 89
IS 7-8
BP 950
EP 954
DI 10.1111/ans.15315
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IN5UI
UT WOS:000478741700055
PM 31230422
DA 2026-07-24
ER

PT J
AU Hong, OY
   Yang, J
   Wan, HY
   Huang, JL
   Yin, YF
AF Hong, Ouyang
   Yang, Jing
   Wan, Haiyan
   Huang, Jiali
   Yin, Yifan
TI Effects of different treatment measures on the efficacy of diabetic foot
   ulcers: a network meta-analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetic foot ulcers; ultrasonic debridement; negative pressure wound
   therapy; stem cells; hyperbaric oxygen therapy; topical oxygen therapy;
   platelet-rich plasma; acellular dermal matrix
ID PLATELET-RICH PLASMA; PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN THERAPY;
   VACUUM-ASSISTED CLOSURE; CONTROLLED-TRIAL; CLINICAL-TRIAL; DOUBLE-BLIND;
   STANDARD; SAFETY; CELLS
AB Introduction Through a network meta-analysis, we compared different treatment measures for patients with diabetic foot ulcers (DFU), assessing their impact on the healing of DFU and ranking them accordingly.Methods We searched the PubMed, the China National Knowledge Infrastructure (CNKI), Embase, the WanFang and the WeiPu database. The retrieval time was from database establishment to January 2024, and retrieval entailed subject and free words. Randomized controlled trials (RCTs) with different treatment measures for DFU were included. Data extraction and evaluation were based on the PRISMA guidelines. Meta-analyses using pairwise and network methods were employed to compare and rank the effectiveness of different treatments for DFU.Results Ultimately, we included 57 RCTs involving a total of 4,826 patients with DFU. When it comes to ulcer healing rates, compared to standard of care(SOC),platelet-rich plasma(PRP), hyperbaric oxygen therapy(HBOT), topical oxygen therapy(TOT), acellular dermal matrix(ADM), and stem cells(SCs) in both direct meta-analysis(DMA) and network meta-analysis(NMA) can effectively increase the complete healing rate. For Scs+PRP, a statistically significant improvement was only observed in the NMA. Moreover, when compared to the negative pressure wound therapy(NPWT) group, the PRP+NPWT group was more effective in promoting the complete healing of ulcers. In terms of promoting the reduction of ulcer area, no statistical differences were observed among various treatment measures. When it comes to ulcer healing time, both PRP and NPWT can effectively shorten the healing time compared to SOC. Furthermore, when compared to the NPWT group, the combined treatment of PRP and ultrasonic debridement(UD) with NPWT is more effective in reducing healing time. In terms of amputation rates and adverse reactions, the PRP group effectively reduced the amputation rate and adverse reactions for patients with DFU. Additionally, compared to the NPWT group, the combined treatment of PRP and UD with NPWT reduced the incidence of adverse reactions. However, no significant differences were observed among other treatment measures in terms of amputation rates and adverse reactions. The ranking results showed that the efficacy of PRP+NPWT and UD+NPWT in promoting ulcer healing, reducing ulcer area, shortening healing time, decreasing amputation rates and adverse reactions is superior to that of the alone PRP group, NPWT group, and UD group. Conversely, the SOC group demonstrates the least effective performance in all aspects.Conclusion Due to the particularity of the wound of DFU, the standard of care is not effective, but the new treatment scheme has a remarkable effect in many aspects. And the treatment of DFU is not a single choice, combined with a variety of methods often achieve better efficacy, and will not bring more adverse reactions.
C1 [Hong, Ouyang; Yang, Jing; Wan, Haiyan; Huang, Jiali] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2,Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu,Dept Endocrine & Metab, Chengdu, Peoples R China.
   [Yin, Yifan] Chengdu Third Peoples Hosp, Dept Nephrol, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Hong, OY; Yang, J; Wan, HY (通讯作者)，Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Clin Med Coll 2,Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu,Dept Endocrine & Metab, Chengdu, Peoples R China.
EM 1668846734@qq.com; yjwyynfm@163.com; 54336623@qq.com
FU Project of Sichuan Medical Association "The effect of Compound Huangbai
   Liquid combined with Dragon blood exhaustive application on chronic
   diabetic lower limb ulcer" [Q20052]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project is
   supported by the project of Sichuan Medical Association "The effect of
   Compound Huangbai Liquid combined with Dragon blood exhaustive
   application on chronic diabetic lower limb ulcer"(No. Q20052).
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NR 122
TC 15
Z9 17
U1 2
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 23
PY 2024
VL 15
AR 1452192
DI 10.3389/fendo.2024.1452192
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H9R6A
UT WOS:001326734400001
PM 39377075
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, X
   Liang, JL
   Zhao, J
   Quan, LL
   Jia, XY
   Li, MC
   Tao, K
AF Liu, Xin
   Liang, Jiulong
   Zhao, Jun
   Quan, Liangliang
   Jia, Xunyuan
   Li, Mingchao
   Tao, Kai
TI Vacuum Sealing Drainage Treatment Combined with Antibiotic-Impregnated
   Bone Cement for Treatment of Soft Tissue Defects and Infection
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Antibiotics, Antineoplastic; Soft Tissue Infections; Vacuum
ID TOTAL KNEE ARTHROPLASTY; TOPICAL ANTIBIOTICS; EMERGING STANDARD;
   PROPHYLACTIC USE; REPLACEMENT; THERAPY; CLOSURE; INJURY
AB Background: This study aimed to evaluate the combined effect of vacuum sealing drainage (VSD) and antibiotic-loaded bone cement on soft tissue defects and infection.
   Material/Methods: This prospective non-blinded study recruited 46 patients with soft tissue defects and infection from January 2010 to May 2014 and randomly divided them into experimental and control groups (n=23). Patients in the experimental group were treated with VSD and antibiotic-loaded bone cement, while the patients in the control group were treated with VSD only.
   Results: In the experimental group, the wound was healed in 23 cases at 4 weeks postoperatively, of which direct suture was performed in 12 cases, and additional free flap transplantation or skin grafting was performed in 6 cases and 5 cases, respectively. No infection reoccurred in 1-year follow-up. In the control group, the wound was healed in 15 cases at 6 weeks postoperatively, of which direct suture was performed in 8 cases, and additional free flap transplantation or skin grafting was performed in 3 cases and 4 cases, respectively. In the other 8 cases the wound was healed at 8 weeks postoperatively. Infection reoccurred in 3 cases during the follow-up. The experimental group had significantly fewer VSD dressing renewals, shorter time needed until the wound was ready for surgery, shorter duration of antibiotic administration, faster wound healing, and shorter hospital stay than the control group (p<0.01).
   Conclusions: The combination of VSD and antibiotic bone cement might be a better method for treatment of soft tissue defects and infection.
C1 [Liu, Xin; Zhao, Jun; Jia, Xunyuan; Li, Mingchao] First Hosp Harbin City, Dept Orthoped Ward 7, Harbin, Heilongjiang, Peoples R China.
   [Liang, Jiulong; Quan, Liangliang; Tao, Kai] Shenyang Mil Area Command PLA, Gen Hosp, Dept Plast Surg, Shenyang, Liaoning, Peoples R China.
RP Liu, X (通讯作者)，First Hosp Harbin City, Dept Orthoped Ward 7, Harbin, Heilongjiang, Peoples R China.; Tao, K (通讯作者)，Shenyang Mil Area Command PLA, Gen Hosp, Dept Plast Surg, Shenyang, Liaoning, Peoples R China.
EM xinliuliud@163.com; kaitaokaitt@163.com
RI ; Li, Mingchao/GZG-5876-2022
OI Liang, Jiulong/0000-0001-6335-4795; 
FU Harbin Innovative Talent in Science and Technology special funds
   [2012RFQYS068]
FX This study was supported by Harbin Innovative Talent in Science and
   Technology special funds (Grant No. 2012RFQYS068)
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NR 32
TC 25
Z9 37
U1 0
U2 21
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 9
PY 2016
VL 22
BP 1959
EP 1965
DI 10.12659/MSM.896108
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DO2RT
UT WOS:000377628300001
PM 27281233
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Goverman, J
   Yelon, JA
   Platz, JJ
   Singson, RC
   Turcinovic, M
AF Goverman, J
   Yelon, JA
   Platz, JJ
   Singson, RC
   Turcinovic, M
TI The "Fistula VAC," a technique for management of enterocutaneous
   fistulae arising within the open abdomen: Report of 5 cases
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE intestinal fistulae; open abdominal wounds; vacuum assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE-CONTROL LAPAROTOMY; ASSISTED
   CLOSURE; PACK TECHNIQUE; TRAUMA; EXPERIENCE
AB Background: Management of intestinal fistulae in open abdominal wounds remains a significant clinical challenge for those caring for patients surviving damage control abdominal operations. Breaking the cycle of tissue inflammation, infection, and sepsis, resulting from leakage of enteric contents, should be a major goal in the approach to these complex patients. We describe a technique utilizing vacuum assisted closure (VAC) which achieves control of enteric flow from fistulae in open abdominal wounds.
   Methods: The fistula-VAC is fashioned from standard sponge supplies, negative pressure pumps, and ostomy appliances. The fistula-VAC was changed every three days prior to split thickness skin grafting, and every five days following grafting.
   Results: Five patients underwent application of the fistula-VAC. All patients had complete diversion of enteric contents. This enteric diversion allowed for successful skin grafting in all patients.
   Conclusion:. Application of the fistula-VAC should be considered a useful option in treating patients with intestinal fistulae in open abdominal wounds.
C1 N Shore Univ Hosp, N Shore Long Isl Jewish Hlth Syst, Manhasset, NY USA.
C3 Northwell Health; North Shore University Hospital
RP Yelon, JA (通讯作者)，New York Med Coll, Munger Pavil, Valhalla, NY 10595 USA.
EM jay_yelon@NYMC.edu
RI Goverman, Jeremy/AAZ-6769-2020
OI Goverman, Jeremy/0000-0001-8717-852X; Yelon, Jay/0000-0001-7980-8042
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NR 13
TC 98
Z9 119
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD FEB
PY 2006
VL 60
IS 2
BP 428
EP 431
DI 10.1097/01.ta.0000203588.66012.c4
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 018MF
UT WOS:000235767700043
PM 16508512
DA 2026-07-24
ER

PT J
AU Buote, NJ
   Havig, ME
AF Buote, Nicole J.
   Havig, Marc E.
TI The Use of Vacuum-Assisted Closure in the Management of Septic
   Peritonitis in Six Dogs
SO JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
LA English
DT Article
ID GENERALIZED PERITONITIS; ABDOMINAL DRAINAGE; CATS; INFECTIONS; THERAPY;
   LACTATE
AB The purpose of this study was to describe the appropriate surgical technique, postoperative monitoring, and complications encountered with use of vacuum-assisted closure (VAC) in six dogs with confirmed septic peritonitis. Initial diagnosis of septic peritonitis was performed by measuring either the blood-to-fluid lactate ratio and glucose concentration differences or cytologic verification of intracellular bacteria. After appropriate surgical procedures were performed to manage the primary cause of peritoneal sepsis, a VAC was performed. Serum and abdominal fluid protein levels were measured, and all complications were noted during the postoperative period. Three of the six dogs (50%) survived to the secondary closure and were subsequent discharged, which is similar to previous studies where the abdomen was either closed primarily or treated with open abdominal drainage. No major complications occurred with bandage management during hospitalization. The results of this study support VAC as a feasible technique for managing septic peritonitis. (J Am Anim Hosp Assoc 2012; 48:164-171. DOI 10.5326/JAAHA-MS-5755)
C1 [Buote, Nicole J.; Havig, Marc E.] Anim Med Ctr, Dept Surg, New York, NY 10021 USA.
RP Buote, NJ (通讯作者)，Vet Ctr Amer W Lost Angeles, Los Angeles, CA 90025 USA.
EM njbuote@aol.com
RI Buote, Nicole/HKF-2946-2023
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NR 29
TC 20
Z9 20
U1 0
U2 16
PU AMER ANIMAL HOSPITAL ASSOC
PI LAKEWOOD
PA PO BOX 150899, LAKEWOOD, CO 80215-0899 USA
SN 0587-2871
EI 1547-3317
J9 J AM ANIM HOSP ASSOC
JI J. Am. Anim. Hosp. Assoc.
PD MAY-JUN
PY 2012
VL 48
IS 3
BP 164
EP 171
DI 10.5326/JAAHA-MS-5755
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 940XO
UT WOS:000303926600002
PM 22474052
DA 2026-07-24
ER

PT J
AU Rao, D
   Kumar, P
   Prabhu, V
AF Rao, Devika
   Kumar, Praveen
   Prabhu, Vijendra
TI Advancements in seawater immersion wound management: Current treatments
   and innovations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE blast injury; microbial infection; seawater immersion wound; soft tissue
   infections; wound management
ID VACUUM-ASSISTED CLOSURE; SKIN; INJURY
AB With advancements in naval warfare, the number and severity of seawater injuries have skyrocketed, necessitating effective seawater immersion (SWI) wound management. The unique marine pathogens, salinity, low temperature and alkalinity of seawater are the main environmental factors that can influence SWI wound healing. The current treatment strategy for SWI wounds follows a standard protocol based on terrestrial wound conditions, neglecting seawater conditions. The key requirements for ideal SWI treatment include good adhesion to the wound surface to minimize further exposure to seawater, enhanced wound healing properties to minimize wound healing time and antibacterial properties to prevent infections from marine pathogens. Current SWI wound-specific treatments range from elaborate techniques like vacuum-sealed drainage and vacuum-assisted closure for severe blast injuries to simple application of hydrogels or collagen dressings for minor injuries. This review discusses the current status and development of various treatment modalities for SWI wounds. The development of these treatment strategies and an understanding of their mechanisms of action make us better prepared to manage and treat SWI injuries.
C1 [Rao, Devika; Kumar, Praveen; Prabhu, Vijendra] Manipal Acad Higher Educ, Manipal Inst Technol, Ctr Microfluid Biomarkers Photoceut & Sensors BioP, Dept Biotechnol,Photoceut & Regenerat Lab, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE)
RP Prabhu, V (通讯作者)，Manipal Acad Higher Educ, Manipal Inst Technol, Ctr Microfluid Biomarkers Photoceut & Sensors BioP, Dept Biotechnol,Photoceut & Regenerat Lab, Manipal 576104, Karnataka, India.
EM vijendra.prabhu@manipal.edu
RI Kumar, Praveen/P-7149-2015; Prabhu, Vijendra/F-7469-2014
OI Prabhu, Vijendra/0000-0001-5927-2180
FU Indian Council of Medical Research [5/4-5/Trauma/2020-NCD-1: 2020-5726]
FX Indian Council of Medical Research, Grant/Award Number:
   5/4-5/Trauma/2020-NCD-1: 2020-5726
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NR 32
TC 8
Z9 9
U1 10
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2024
VL 21
IS 10
AR e70070
DI 10.1111/iwj.70070
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DD1YD
UT WOS:001680623600001
PM 39353589
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU D'Hondt, M
   De Hondt, G
   Malisse, P
   Vanden Boer, J
   Knol, J
AF D'Hondt, Mathieu
   De Hondt, Geert
   Malisse, Paul
   Vanden Boer, Jan
   Knol, Joep
TI Chronic pelvic abscedation after completion proctectomy in an irradiated
   pelvis: another indication for ENDO-sponge treatment?
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE ENDO-sponge (R); Irradiated pelvis; Presacral abscess; Proctectomy
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; WOUND CONTROL;
   RADIOTHERAPY; RESECTION
AB Six years after completion proctectomy, a patient presented with invalidating pain, fever and massive mucopurulent secretion through the perineal wound after completion proctectomy. CT-scan revealed a large presacral abscess and osteonecrosis of the sacrum. The patient consented to placement of an ENDO-sponge(A (R)) (B. Braun Medical B.V., Melsungen Germany). On day 4 granulation tissue covered the walls of the cavity and the amount of necrotic tissue and fibrin was reduced. The foam was changed every 4 days and treatment was continued for 20 days. On day 20, vacuum assisted closure therapy was stopped and the remnant cavity was further rinsed with saline. There was no more evacuation of mucus or pus. Three months later, the patient was symptom free and only a small perineal dimple remained. ENDO-sponge(A (R)) (B. Braun Medical B.V., Melsungen Germany) treatment is possible for presacral abscedation which is a well-known complication following abdominoperineal rectum amputation.
C1 [D'Hondt, Mathieu; Malisse, Paul; Vanden Boer, Jan; Knol, Joep] Maria Ziekenhuis Noord Limburg, Dept Digest Surg, B-3900 Overpelt, Belgium.
   [De Hondt, Geert] Maria Ziekenhuis Noord Limburg, Dept Internal Med, B-3900 Overpelt, Belgium.
RP D'Hondt, M (通讯作者)，Kleine Leiestr 1, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Kapiteijn E, 2001, NEW ENGL J MED, V345, P638, DOI 10.1056/NEJMoa010580
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NR 10
TC 9
Z9 9
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD DEC
PY 2009
VL 13
IS 4
BP 311
EP 314
DI 10.1007/s10151-009-0505-3
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 521YV
UT WOS:000271963500011
PM 19603139
DA 2026-07-24
ER

PT J
AU Abild, N
   Bulut, O
   Nielsen, CB
AF Abild, N.
   Bulut, O.
   Nielsen, C. B.
TI ENDOSCOPIC STAPLED MARSUPIALISATION OF CHRONIC PRESACRAL SINUS FOLLOWING
   LOW ANTERIOR RESECTION: A SIMPLE OPTION IN SELECTED CASES
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Chronic presacral sinus; anastomotic leakage; colorectal cancer;
   endoscopic stapled marsupialisation; low anterior resection; colorectal
   surgery
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC SINUSES; MESORECTAL EXCISION;
   RECTAL-CANCER
AB Background and Aims: Chronic presacral sinus (CPS) following anastomose leakage is one of the most serious complications after restorative colorectal surgery. CPS is associated with long course of treatments and can prevent stoma closure. We present our experience with endoscopic stapled marsupialisation (ESM) of CPS.
   Materials and Methods: Seven patients underwent ESM. All patients had developed a CPS after clinical anastomotic leakage following low anterior resection with diverting ileostomy. Initially the patients were treated conservatively and with endoscopic vacuum-assisted closure (Endo-VAC).
   Results and Conclusion: ESM procedure was successful for six patients, resulted in good healing in four patients and no sinus recurrence of the CPS. In two patients the stoma was reversed. Two patients were treated with neo-adjuvant chemoradiotherapy, who also developed small bowel fistulae. ESM is a simple treatment for CPS and can accelerate healing of chronic presacral cavity, reduce complications and enable to reverse the stoma in selected cases.
C1 [Abild, N.; Bulut, O.; Nielsen, C. B.] Univ Copenhagen, Hvidovre Univ Hosp, Dept Surg Gastroenterol, Copenhagen, Denmark.
C3 University of Copenhagen
RP Bulut, O (通讯作者)，Univ Copenhagen, Hvidovre Univ Hosp, Dept Surg Gastroenterol, Kettegaards Alle 30, DK-2650 Hvidovre, Denmark.
EM Orhan.Bulut@hvh.regionh.dk
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   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Nesbakken A, 2001, BRIT J SURG, V88, P400, DOI 10.1046/j.1365-2168.2001.01719.x
   PAGNI S, 1995, DIS COLON RECTUM, V38, P433, DOI 10.1007/BF02054236
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   Whitlow CB, 1997, DIS COLON RECTUM, V40, P760, DOI 10.1007/BF02055427
NR 10
TC 12
Z9 16
U1 0
U2 1
PU FINNISH SURGICAL SOC
PI HELSINKI
PA MAKELANKATU 2 C, PO BOX 49, SF-00501 HELSINKI, FINLAND
SN 1457-4969
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2012
VL 101
IS 4
BP 307
EP 310
DI 10.1177/145749691210100416
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 062LU
UT WOS:000312922100016
PM 23238510
DA 2026-07-24
ER

PT J
AU de Weerd, L
   Kjoeve, J
   Aghajani, E
   Elvenes, OP
AF de Weerd, Louis
   Kjoeve, Jorn
   Aghajani, Ebrahim
   Elvenes, Odd P.
TI The sandwich design - A new method to close a high-output
   enterocutaneous fistula and an associated abdominal wall defect
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE enterocutaneous fistula; free flap; vacuum-assisted closure system
ID GASTROINTESTINAL FISTULAS; LATISSIMUS-DORSI; MANAGEMENT; EXPERIENCE;
   NUTRITION; SURGERY; SYSTEM
AB Fistulas draining through large abdominal wall defects are exceptionally difficult to treat and are associated with a very high mortality. This case report describes a new method for closure of these fistulas where prior conservative and surgical treatment had failed. Initial use of a vacuum-assisted closure (VAC) system optimized wound care and led to coverage of the exposed intestines with granulation tissue. The serratus muscle of a composite free latissimus dorsi-serratus flap was used to close the fistula, while the large abdominal wall defect was closed with the musculocutaneous latissimus dorsi flap. Temporary placement of a VAC system between the serratus muscle and the latissimus dorsi muscle immobilized the serratus to the fistula and counteracted changes in abdominal pressure. The layering of muscle, VAC system, and muscle resembles a sandwich. The advantage of the sandwich design is an extraperitoneal approach that provides tension-free closure of the fistula and abdominal wall, with well-vascularized tissue.
C1 Univ Hosp N Norway, Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North Norway
RP de Weerd, L (通讯作者)，Dept Plast & Reconstruct Surg & Hand Surg, Sykehus Veien 38,POB 66, N-9038 Tromso, Norway.
EM louis.deweerd@unn.no
OI Aghajani, Ebrahim/0000-0002-4383-9581
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NR 14
TC 11
Z9 11
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2007
VL 58
IS 5
BP 580
EP 583
DI 10.1097/01.sap.0000237643.45125.8b
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 161RK
UT WOS:000246033000022
PM 17452848
DA 2026-07-24
ER

PT J
AU Bundele, V
   Aggarwal, N
   Bana, A
AF Bundele, Varsha
   Aggarwal, Neha
   Bana, Ajeet
TI Large Sternoabdominal Wound Dehiscence after Cardiac Surgery:
   Challenging Multimodal Treatment
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Editorial Material
DE abdominal; chronic; dehiscence; sternum; surgery; wound healing
ID VACUUM-ASSISTED CLOSURE; INFECTIONS; COMPLICATIONS; MANAGEMENT;
   MORBIDITY
AB The authors report the case of a patient who presented with a nonhealing sternal wound 3 months after cardiac bypass surgery. The patient was treated with vacuum-assisted closure, surgical debridement, and IV antibiotics. Despite repeated flap closure procedures, a top closure device, and wound dressings, the patient developed an infection, and the wound size increased from 8 x 10 cm to 20 x 20 cm, advancing from the sternal to upper abdominal region. This wound was then treated with hyperbaric oxygen therapy and nonmedicated dressings until the patient was eligible to receive a split-thickness skin graft 1.5 years after initial presentation.
   The main takeaway from this case was that local and systemic factors affected the outcome of each surgical closure. The failure of each preceding treatment choice that led to further increases in size and area of the wound was the main challenge. Eliminating infection, preventing development of new infection, and managing the local and systemic factors before any definite surgery are key to the eventual wound closure.
C1 [Bundele, Varsha] Eternal Hosp, Jaipur, Rajasthan, India.
   [Aggarwal, Neha] Eternal Hosp, Plast Surg Team, Oral & Maxillofacial Surg, Jaipur, Rajasthan, India.
   [Bana, Ajeet] Eternal Hosp, Cardiac Sci, Jaipur, Rajasthan, India.
RP Bundele, V (通讯作者)，Eternal Hosp, Jaipur, Rajasthan, India.
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NR 12
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2023
VL 36
IS 5
BP 4
EP 5
PG 2
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA E9PY6
UT WOS:000978787400002
DA 2026-07-24
ER

PT J
AU Laperuta, P
   Napolitano, F
   Vatrella, A
   Di Crescenzo, RM
   Cortese, A
   Di Crescenzo, V
AF Laperuta, Paolo
   Napolitano, Filomena
   Vatrella, Alessandro
   Di Crescenzo, Rosa Maria
   Cortese, Antonio
   Di Crescenzo, Vincenzo
TI Post-pneumonectomy broncho-pleural fistula successfully closed by
   open-window thoracostomy associated with VAC therapy
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Post-pneumonectomy broncho-pleural fistula; Open-window thoracostomy;
   Vacuum assisted closure therapy
ID NEEDLE-ASPIRATION-CYTOLOGY; LYMPH-NODE; HODGKIN-LYMPHOMA; EMPYEMA SPACE;
   CLOSURE; LESIONS; FLAPS
AB Broncho-pleural fistula (BPF), is a dramatic complication that may occur after lung resection. The treatment is challenging due to its high rate of morbidity and mortality. Herein, a case of BPF associated with empyema, occurred in an elderly patient who had undergone to left pneumonectomy for non-small cell lung cancer (NSCLC), is reported. After various treatments including chest drainage and endoscopic procedures, BPF was successfully closed by open-window thoracotomy associated with vacuum assisted closure (V.A.C.) device therapy. The authors conclude that V.A.C. is a convenient and safe measure in the management of empyema with BPF. Moreover, in similar clinical contexts, V.A.C. may be the only option available that may assure the survival of the patient and the avoiding any later-phases of residual cavity. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Laperuta, Paolo; Napolitano, Filomena; Vatrella, Alessandro; Di Crescenzo, Rosa Maria; Cortese, Antonio; Di Crescenzo, Vincenzo] Univ Salerno, Dept Med & Surg, Unit Maxillofacial Surg, I-84100 Salerno, Italy.
C3 University of Salerno
RP Di Crescenzo, V (通讯作者)，Univ Salerno, Dept Med & Surg, Thorac Surg, I-84131 Salerno, Italy.
EM laper@libero.it; milena.napolitano@yahoo.it; avatrella@unisa.it;
   vdcres@alice.it; ancortese@unisa.it; vdicrescenzo@unisa.it
RI Vatrella, Alessandro/K-8001-2016; cortese, antonio/K-7317-2016; di
   crescenzo, rosa maria/HKW-6011-2023
OI Vatrella, Alessandro/0000-0001-8265-3037; cortese,
   antonio/0000-0002-0875-0725; di crescenzo, rosa
   maria/0000-0003-0404-0141; Di Crescenzo, Vincenzo/0000-0001-8745-8089
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NR 24
TC 11
Z9 14
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD OCT
PY 2014
VL 12
SU 2
BP S17
EP S19
DI 10.1016/j.ijsu.2014.08.390
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CR0ER
UT WOS:000360991700005
PM 25159544
DA 2026-07-24
ER

PT J
AU de Abreu, IRLB
   Pontes, EPO
   Tamagno, MFL
   Sardenberg, RA
   Younes, RN
   Abrao, FC
AF de Abreu, Igor Renato L. B.
   Pontes, Edgard P. O.
   Tamagno, Mauro F. L.
   Sardenberg, Rodrigo Afonso
   Younes, Riad Naim
   Abrao, Fernando Conrado
TI Treatment of thoracic wounds with adapted vacuum therapy
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infections; thoracic wounds; vacuum therapy
ID ASSISTED CLOSURE; EMPYEMA
AB This is a report of seven cases of infected thoracic wounds treated with an adapted low-cost vacuum therapy in the Thoracic Surgery Unit of Santa Marcelina Hospital. The vacuum system used was designed and adapted to our hospital due to financial limitations on the acquisition of commercial kits. The vacuum-assisted closure kit used in this study consisted of chlorhexidine sponges (which are usually used for antisepsis of the surgical team), a 16F naso-gastric tube, and two sterile adhesive films (OPSITE) for surgical field reinforcement. The mean duration of vacuum therapy was 13.4 days (range, 10-20 days), with an average of three dressing changes (range, 1-5). After treatment with vacuum-assisted closure, three wounds (3/7) were closed with simple primary sutures, one of the lesions (1/7) was closed by muscle flap rotation, and three wounds (3/7) healed by second intention. This adapted vacuum therapy was safe and easy to apply in our institution, including its use in patients with thoracostomies. Copyright (C) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [de Abreu, Igor Renato L. B.; Abrao, Fernando Conrado] Hosp Santa Marcelina, Oncol Ctr Hosp Sao Jose, Dept Thorac Surg, Sao Paulo, Brazil.
   [Pontes, Edgard P. O.; Tamagno, Mauro F. L.] Hosp Santa Marcelina, Dept Thorac Surg, Sao Paulo, Brazil.
   [Sardenberg, Rodrigo Afonso] Hosp Sao Jose, Ctr Oncol, Sao Paulo, Brazil.
   [Younes, Riad Naim] Univ Sao Paulo, Dept Surg, Hosp Sao Jose, Ctr Oncol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Abrao, FC (通讯作者)，Rua Souza Ramos 144,Apto 11, BR-04120080 Sao Paulo, Brazil.
EM fernandocabrao@uol.com.br
OI Abreu, Igor/0000-0003-2071-1427
CR MILLER JI, 1984, ANN THORAC SURG, V38, P227, DOI 10.1016/S0003-4975(10)62243-6
   Molnar TF, 2007, EUR J CARDIO-THORAC, V32, P422, DOI 10.1016/j.ejcts.2007.05.028
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   O'Connor J, 2005, ANN THORAC SURG, V79, P1196, DOI 10.1016/j.athoracsur.2004.09.041
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
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   Widmer MK, 2000, EUR J CARDIO-THORAC, V18, P435, DOI 10.1016/S1010-7940(00)00538-8
NR 7
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 49
EP 52
DI 10.1016/j.asjsur.2013.07.015
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800009
PM 24026077
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Gouttefangeas, C
   Eberle, M
   Ruck, P
   Stark, M
   Müller, JE
   Becker, HD
   Rammensee, HG
   Pinocy, J
AF Gouttefangeas, C
   Eberle, M
   Ruck, P
   Stark, M
   Müller, JE
   Becker, HD
   Rammensee, HG
   Pinocy, J
TI Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams
   during surgical wound closure therapy
SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY
LA English
DT Article
DE bacteria; leucocyte; vaccum-assisted closure; wound healing
ID SPONGE MATRIX MODEL; VACUUM-ASSISTED CLOSURE; LEUKOCYTE; CELLS;
   RECRUITMENT; MACROPHAGE; MECHANISMS; CYTOKINES; IMMUNITY; REPAIR
AB Vacuum-assisted closure involving the implantation of polyvinyl alcohol foam is a technique recently developed for the treatment of patients suffering from either wound infection or chronic wounds. This method has been shown to improve and accelerate wound healing. However, little is known about the cell populations that infiltrate the foam, and their potential role in resolving the infection and promoting granulation tissue formation. Our study demonstrates that wound-implanted foams are mainly infiltrated with granulocytes, but that mononuclear cells, including macrophages and minor populations of T, B and natural killer lymphocytes, are also present. We show that foam-infiltrating T cells, especially CD4(+) T cells, constitute a phenotypically and functionally heterogeneous population influenced by wound-infecting bacteria. Thus, T lymphocytes could play a role in wound cleansing. In addition, our data indicate that implanted polyvinyl alcohol foams might be suitable microenvironments for manipulating T cell-mediated immune responses in patients.
C1 Univ Tubingen, Inst Cell Biol, Dept Immunol, D-72076 Tubingen, Germany.
   Univ Tubingen, Inst Pathol, Dept Histo & Cytopathol, D-7400 Tubingen, Germany.
   Univ Tubingen, Inst Hyg, Dept Med Microbiol, Tubingen, Germany.
   Berufsgenossenschaftliche Unfallklin, Ctr Trauma, Tubingen, Germany.
   Berufsgenossenschaftliche Unfallklin, Dept Traumatol, Tubingen, Germany.
   Univ Tubingen, Dept Surg, Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Eberhard Karls University
   of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Eberhard Karls University of Tubingen; Eberhard
   Karls University Hospital; Eberhard Karls University of Tubingen
RP Rammensee, HG (通讯作者)，Univ Tubingen, Inst Cell Biol, Dept Immunol, Morgenstelle 15, D-72076 Tubingen, Germany.
EM rammensee@uni-tuebingen.de
RI Ruck, Patrick/NVM-8950-2025
CR AKPORIAYE ET, 1985, CANCER RES, V45, P6457
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NR 30
TC 28
Z9 58
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0009-9104
EI 1365-2249
J9 CLIN EXP IMMUNOL
JI Clin. Exp. Immunol.
PD JUN
PY 2001
VL 124
IS 3
BP 398
EP 405
DI 10.1046/j.1365-2249.2001.01547.x
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 452VT
UT WOS:000169880900009
PM 11472400
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cirkovic, I
   Jocic, D
   Bozic, DD
   Djukic, S
   Konstantinovic, N
   Radak, D
AF Cirkovic, Ivana
   Jocic, Dario
   Bozic, Dragana D.
   Djukic, Slobodanka
   Konstantinovic, Neda
   Radak, Djordje
TI The Effect of Vacuum-Assisted Closure Therapy on Methicillin-Resistant
   Staphylococcus aureus Wound Biofilms
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE antibiofilm effect; biofilm; dressing change frequency;
   methicillin-resistant Staphylococcus aureus; MRSA; VAC therapy; wound
   infection
ID NEGATIVE-PRESSURE; INFECTION; RESPONSES
AB Biofilm-associated wound infections are a major global health issue, and methicillin-resistant Staphylococcus aureus (MRSA) is among the greatest therapeutic challenges. Vacuum-assisted closure (VAC) therapy is now being revisited as an alternative treatment for both acute and chronic wounds. However, data supporting the concept of its antibiofilm effect remain limited. Using quantitative biofilm-forming assay and a range of genotypic methods (spa, SCCmec, and agr typing), study authors showed that VAC therapy can significantly prevent biofilm formation (P < .01) of a range of MRSA wound isolates differing widely in their biofilm-forming abilities and genetic background. The best effect was presented on CC5-MRSA-SCCmecI-agrII, a dominant MRSA clone among wound isolates worldwide. An assessment of effects of different protocols on dressing changes (1 or 2 times per week) demonstrated significantly greater antibiofilm activity (P < .05) of 3-day dressing changes. These findings support the use of VAC therapy as a topical antibiofilm treatment for the effective management of wound healing.
C1 [Cirkovic, Ivana] Univ Belgrade, Inst Microbiol, Microbiol, Belgrade, Serbia.
   [Jocic, Dario] Univ Belgrade, Fac Pharm, Inst Cardiovasc Dis, Belgrade, Serbia.
   [Bozic, Dragana D.] Univ Belgrade, Fac Pharm, Dept Microbiol & Immunol, Microbiol, Belgrade, Serbia.
   [Djukic, Slobodanka] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Microbiol, Belgrade, Serbia.
   [Konstantinovic, Neda] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Belgrade, Serbia.
   [Radak, Djordje] Univ Belgrade, Inst Cardiovasc Dis, Vasc Surg, Fac Med, Belgrade, Serbia.
   [Radak, Djordje] Univ Belgrade, Surg, Fac Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Cirkovic, I (通讯作者)，Univ Belgrade, Inst Microbiol, Microbiol, Belgrade, Serbia.
OI Bozic, agana/0000-0002-5373-5540; Cirkovic, Ivana/0000-0003-1515-1824
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [ON175039]
FX This research was supported by the Ministry of Education, Science and
   Technological Development, Republic of Serbia (project no. ON175039).
   The authors have disclosed no other financial relationships related to
   this article. Submitted July 26, 2017; accepted in revised form January
   2, 2018. Supplemental digital content is available for this article.
   Direct URL citations appear in the printed text and are provided in the
   HTML and PDF versions of this article on the journal's Web site.
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NR 17
TC 3
Z9 6
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2018
VL 31
IS 8
BP 361
EP 364
DI 10.1097/01.ASW.0000540070.07040.70
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GO4AJ
UT WOS:000439942000005
PM 30028372
DA 2026-07-24
ER

PT J
AU Zhou, R
   Qiu, L
   Xiao, J
   Mao, XB
   Yuan, XG
AF Zhou, Rong
   Qiu, Lin
   Xiao, Jun
   Mao, Xiaobo
   Yuan, Xingang
TI Early Wound Repair Versus Later Scar Repair in Children with Treadmill
   Hand Friction Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS; MANAGEMENT; INJURIES; CLOSURE;
   THERAPY
AB The incidence of pediatric treadmill hand friction burns has been increasing every year. The injuries are deeper than thermal hand burns, the optimal treatment remains unclear. This was a retrospective study of children who received surgery for treadmill hand friction burns from January 1, 2015, to December 31, 2019, in a single burn center. A total of 22 children were surveyed. The patients were naturally divided into two groups: the wound repair group (13 patients), which was admitted early to the hospital after injury and received debridement and vacuum sealing drainage initially, and a full-thickness skin graft later; and the scar repair group (nine patients), in which a scar contracture developed as a result of wound healing and received scar release and skin grafting later. The Modified Michigan Hand Questionnaire score in the wound repair group was 116.31 +/- 10.55, and the corresponding score in the scar repair group was 117.56 +/- 8.85 (p >.05), no statistically significant difference. The Vancouver Scar Scale score in the wound repair group was 4.15 +/- 1.21, and the corresponding score in the scar repair group was 7.22 +/- 1.09 (p <.05). Parents were satisfied with the postoperative appearance and function of the hand. None in the two groups required secondary surgery. If the burns are deep second degree, third degree, or infected, early debridement, vacuum sealing drainage initially, and a full-thickness skin graft can obviously relieve pediatric pain, shorten the course of the disease, and restore the function of the hand as soon as possible.
C1 [Zhou, Rong; Qiu, Lin; Xiao, Jun; Mao, Xiaobo; Yuan, Xingang] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Burns & Plast Surg,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Childre, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Yuan, XG (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Burns & Plast Surg, 136 Zhongshan Er Rd, Chongqing 400014, Peoples R China.
EM 535538769@qq.com
OI , Rong/0000-0001-7464-3525
CR Banever GT, 2003, J CRANIOFAC SURG, V14, P487, DOI 10.1097/00001665-200307000-00017
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NR 27
TC 6
Z9 8
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2022
VL 43
IS 1
BP 269
EP 276
DI 10.1093/jbcr/irab083
EA MAY 2021
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA YI7EI
UT WOS:000744007600037
PM 34015124
DA 2026-07-24
ER

PT J
AU Wang, ZH
   Liu, T
   Cheng, YH
   Xin, DJ
   Qu, WQ
   Jiang, YG
   Wang, D
AF Wang, Zhenhai
   Liu, Tong
   Cheng, Yiheng
   Xin, Dajiang
   Qu, Wenqing
   Jiang, Yugui
   Wang, Dan
TI Tibial Nail Combined with Vacuum Sealing Drainage for Gustilo Grade IIIB
   Open Tibial Fractures: A Patient Series
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE intramedullary nail; open fracture; postoperative complication; tibia;
   trauma
ID MANAGEMENT
AB Gustilo grade IIIB open tibial fractures are relatively difficult to treat. We investigated the treatment effects of tibial intramedullary nails combined with vacuum sealing drainage (VSD) for Gustilo grade IIIB open tibial fractures. From March 2015 to March 2017, 13 cases of Gustilo grade IIIB open tibial fractures were treated with Expert Tibial Nails combined with VSD. Causes of injury included falls from a height (n = 9, 69.2%) and road accidents (n = 4, 30.8%). The duration from time of injury to hospital intake was 7.3 hours (range 5 to 9.5), and the time between injury and operation was 6.7 days (range 3 to 11). Six months after the operation, overall patient general health was investigated via the American Orthopaedic Foot and Ankle Society (AOFAS) ankle score and the physical and mental health dimensions of the Short-Form Health Survey 36 (SF-36). Postoperative complications and infections also were recorded. The results indicated that the median AOFAS score was 93.7 (range 89 to 97), with all individuals having either excellent (90 to 100; n = 10, 76.9%) or good (80 to 89; n = 3, 23.1%) outcomes. The median physical SF-36 score was 83.1 (range 72.5 to 93.0), and the median mental SF-36 score was 80.6 (range 69.7 to 92.0). Moreover, there were no instances of tibial shortening, neurovascular injury, postoperative complications, implant failure, malunion, or serious infections. In conclusion, intramedullary tibial nail combined with VSD is a safe and effective method to treat type grade IIIB open tibial fractures. (C) 2019 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Wang, Zhenhai; Liu, Tong; Cheng, Yiheng; Xin, Dajiang; Qu, Wenqing; Jiang, Yugui; Wang, Dan] Yantaishan Hosp, Yantai, Peoples R China.
   [Wang, Zhenhai; Liu, Tong; Cheng, Yiheng; Xin, Dajiang; Qu, Wenqing; Jiang, Yugui; Wang, Dan] Yantai Sino French Friendship Hosp, Yantai, Peoples R China.
RP Wang, ZH (通讯作者)，Yantaishan Hosp, Dept Orthopaed & Traumatol, Yantai 264000, Peoples R China.
EM ytzhenhai@163.com
CR Akgun U, 2019, J FOOT ANKLE SURG, V58, P497, DOI 10.1053/j.jfas.2018.09.027
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NR 17
TC 3
Z9 8
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2020
VL 59
IS 2
BP 409
EP 412
DI 10.1053/j.jfas.2019.08.016
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KQ7HN
UT WOS:000517090300032
PM 32131012
DA 2026-07-24
ER

PT J
AU Wanner, MB
   Schwarzl, F
   Strub, B
   Zaech, GA
   Pierer, G
AF Wanner, MB
   Schwarzl, F
   Strub, B
   Zaech, GA
   Pierer, G
TI Vacuum-assisted wound closure for cheaper and more comfortable healing
   of pressure sores: A prospective study
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article
DE vacuum treatment; pressure sores; wound healing
ID SEALING TECHNIQUE; ULCERS
AB Pressure sores are a common complication of patients with spinal injuries. The vacuum-assisted closure technique is widely used to induce and promote wound healing. We tested our clinical impression that pressure sores healed faster with vacuum-assisted closure, and compared it with the traditional wet-to-dry/wet-to-wet technique with gauze soaked in Ringer's solution changed three times a day. Consecutive patients with pressure sores were entered into the study. Two randomised groups of 11 patients each with pressure sores of the pelvic region were included. We found no difference in time to reach 50% of the initial wound volume between the two methods. The vacuum-assisted group took a mean (SD) of 27 (10) days and the traditional group 28 (7) days. The two methods were equally effective in forming granulation tissue, so one can profit from the other advantages of the vacuum-assisted treatment (reduced costs and improved comfort) knowing that the effect on the formation of granulation tissue is as good as with the traditional treatment.
C1 Swiss Parapleg Ctr, CH-6207 Nottwil, Switzerland.
   Univ Basel Hosp, Clin Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
C3 Swiss Paraplegic Research; University of Basel
RP Wanner, MB (通讯作者)，Swiss Parapleg Ctr, CH-6207 Nottwil, Switzerland.
EM marcus.wanner@paranet.ch
CR Allman R M, 1999, Adv Wound Care, V12, P22
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NR 19
TC 104
Z9 114
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2003
VL 37
IS 1
BP 28
EP 33
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 645DR
UT WOS:000180961400006
PM 12625392
DA 2026-07-24
ER

PT J
AU Medina-Valarezo, D
   Gallardo-Arrieta, F
   Paredes-Carvajal, P
   Camacho-Pazmiño, M
AF Medina-Valarezo, Diego
   Gallardo-Arrieta, Fanny
   Paredes-Carvajal, Pamela
   Camacho-Pazmino, Martha
TI Negative pressure assisted by vacuum closure as an adjuvant to te graft
   for the treatment of complex wounds in a domestic dog. CASE REPORT.
SO REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS
LA Spanish
DT Article
DE Graft; negativepressure; VAC; veterinary wounds; wounds in dogs
ID THICKNESS SKIN-GRAFTS; THERAPY
AB The treatment of wounds in veterinary patients continues to be a major challenge. Innovations in medical technology have enabled the adoption of advanced techniques that enhance the wound healing process and reduce overall recovery time. This case report presents the application of vacuum-assisted closure negative pressure therapy to support a skin graft in a canine patient. This approach uses a porous open-cell foam placed on the wound bed, sealed with adhesive transparent film and connected to a programmable device that generates subatmospheric pressure ranging from 50 to 200 mmHg. The setup creates a sealed and anaerobic environment, facilitating wound management. In this case, a chronic non-healing wound was treated with a scrotal skin autograft from the same animal. The integration of the graft into the lesion bed was enhanced through negative pressure application, achieving full adherence within 10 hours. These findings support the effectiveness of application of vacuum-assisted closure therapy in veterinary skin graft procedures.
C1 [Medina-Valarezo, Diego; Camacho-Pazmino, Martha] Hosp Vet Planeta Vida, Latacunga, Ecuador.
   [Medina-Valarezo, Diego; Gallardo-Arrieta, Fanny] Univ Zulia, Fac Ciencias Vet Maracaibo, Zulia, Venezuela.
   [Medina-Valarezo, Diego; Paredes-Carvajal, Pamela] Uiversidad Reg Autonoma Andes, UNIANDES, Quevedo, Ecuador.
C3 Universidad Regional Autonoma de los Andes (UNIANDES)
RP Medina-Valarezo, D (通讯作者)，Hosp Vet Planeta Vida, Latacunga, Ecuador.; Medina-Valarezo, D (通讯作者)，Univ Zulia, Fac Ciencias Vet Maracaibo, Zulia, Venezuela.; Medina-Valarezo, D (通讯作者)，Uiversidad Reg Autonoma Andes, UNIANDES, Quevedo, Ecuador.
EM diego_xavier_mv@hotmail.com
CR Becker ST, 2010, INT J ORAL MAX SURG, V39, P699, DOI 10.1016/j.ijom.2010.03.016
   Depoortère C, 2020, EMC - Cirugía Plástica Reparadora y Estética, V28, P1, DOI 10.1016/s1634-2143(20)43810-5
   Fernandez-Gonzalez T, 1988, CLIN VET PEQUENOS AN, V8, P169
   Fresneda Pimiento J, 2019, REV CENDEROS, V11, P80
   García-Ruiz María Piedad, 2022, Gerokomos, V33, P274
   Huppes RR, 2024, CIRUGIA RECONSTRUCTI
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Martínez-Castilla Juan M, 2021, Cir. plást. iberolatinoam., V47, P95, DOI [10.4321/s0376-78922021000100013, 10.4321/s0376-78922021000100013]
   Mosquera Ortiz R, 2021, TESIS GRADO
   Nolff MC, 2015, J FELINE MED SURG, V17, P1041, DOI 10.1177/1098612X15569893
   Pavletic MM, 2018, ATLAS SMALL ANIMAL W
   Stanley BJ, 2013, VET SURG, V42, P511, DOI 10.1111/j.1532-950X.2013.12005.x
   Valarezo DXM, 2023, SALUD CIENC TECNOL, V3, P382
   Waltzman JT, 2014, J BURN CARE RES, V35, pE338, DOI 10.1097/BCR.0000000000000009
NR 14
TC 0
Z9 0
U1 0
U2 2
PU UNIV ZULIA, FACULTAD CIENCIAS VETERINARIAS
PI MARACAIBO
PA UNIVERSIDAD DEL ZULIA, MARACAIBO, VENEZUELA
SN 0798-2259
J9 REV CIENT-FAC CIEN V
JI Rev. Cient.-Fac. Cienc. Vet.
PY 2025
VL 35
IS 3
AR 5
DI 10.52973/rcfcv-e35661
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 9QA8W
UT WOS:001612305000009
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Scala, M
   Spagnolo, F
   Trapasso, M
   Strada, P
   Moresco, L
   Santi, P
AF Scala, Marco
   Spagnolo, Francesco
   Trapasso, Maria
   Strada, Paolo
   Moresco, Luciano
   Santi, Pierluigi
TI Association of Vacuum-assisted Closure and Platelet Gel for the
   Definitive Surgical Repair of an Enterocutaneous Fistula: A Case Report
SO IN VIVO
LA English
DT Article
DE Platelet gel; VAC therapy; regenerative surgery; fistula; wound healing
ID CHRONIC WOUNDS; RICH PLASMA; THERAPY; GRAFTS
AB Background: Regenerative surgery deals with damaged tissue via endogenous cell activation or through autologous cell implantation. Several clinical applications employing cell infusions, platelet gel (PG), or both, are currently applied in cases in which no other therapy is application. The vacuum-assisted closure (VAC) system is a non invasive device used in the management of complicated wounds, which creates sub-atmospheric pressure promoting the wound healing process. Patients and Methods: We describe the case of a 75-year-old woman who underwent several surgical interventions and presented a non-healing ileo-cutaneous fistula. All standard procedures in order to treat the trauma failed, so a treatment associating VAC and PG was performed. Discussion and Conclusion: VAC and PG represent promising opportunities for the treatment of difficult wounds. In this case, the association of regenerative medicine using homologous PG to the VAC therapy was employed in order to enhance the effect of both techniques on tissue repair.
C1 [Scala, Marco] Natl Inst Canc Res IST, Div Surg Oncol, Genoa, Italy.
   [Spagnolo, Francesco; Trapasso, Maria] Natl Inst Canc Res IST, Div Plast Surg, Genoa, Italy.
   [Strada, Paolo] St Martino Hosp, Blood Trasfus Ctr, Genoa, Italy.
   [Moresco, Luciano; Santi, Pierluigi] Univ Genoa, Fac Med, Genoa, Italy.
C3 University of Genoa; IRCCS AOU San Martino IST; University of Genoa;
   IRCCS AOU San Martino IST; University of Genoa
RP Scala, M (通讯作者)，Ist Nazl Ric Canc, SC Oncol Chirurg A, Lgo R Benzi 10, I-16132 Genoa, Italy.
EM marco.scala@hotmail.it
RI Spagnolo, Francesco/AAC-3006-2019
OI Spagnolo, Francesco/0000-0003-3287-1225
CR Akingboye Akinfemi Ayobami, 2010, J Extra Corpor Technol, V42, P20
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   Crovetti G, 2004, TRANSFUS APHER SCI, V30, P145, DOI 10.1016/j.transci.2004.01.004
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NR 18
TC 6
Z9 6
U1 0
U2 4
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JAN-FEB
PY 2012
VL 26
IS 1
BP 147
EP 150
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 868HX
UT WOS:000298515400021
PM 22210730
DA 2026-07-24
ER

PT J
AU Qian, YY
   He, D
   Qi, HZ
   Zhang, T
   Fu, T
   Yu, MH
   Yan, Q
   Cai, ZY
   Liu, YM
AF Qian, Yuanyi
   He, Di
   Qi, HaoZhao
   Zhang, Tian
   Fu, Tao
   Yu, Menghua
   Yan, Qin
   Cai, Zhuoying
   Liu, Yanming
TI Comparative Study of Multifunctional Irrigation-assisted Vacuum
   Drainage, Vacuum Sealing Drainage and the Penrose Drain in Treating
   Severe Multi-space Deep Fascial Infection in the Head and Neck
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID PRESSURE-WOUND-THERAPY; ODONTOGENIC INFECTIONS; SPACE INFECTIONS;
   MANAGEMENT; IMPACT
AB Background We aimed to compare multifunctional irrigation-assisted vacuum drainage (MIVD), vacuum sealing drainage (VSD) and the Penrose drain in treating severe multi-space deep fascial infection (DFI) in head and neck. Methods A retrospective study was conducted on 113 patients who had suffered from severe multi-space DFI in head and neck and underwent surgical treatment. Patients were divided into the MIVD group, the VSD group, and the Penrose group according to their treatment. Baseline characteristics and clinical outcome data regarding infection control, clinicians' workload, surgical procedure required, and cost were analyzed. Results Duration of antibiotic administration was significantly shorter using MIVD and VSD than Penrose drains (p = 0.002 with MIVD, p = 0.008 with VSD). Hospital stay in the MIVD group was shorter than the Penrose group (p = 0.034). Compared to the other two groups, more times of manual irrigation were needed in higher frequency in the Penrose group (p < 0.001). Longer Incision and more surgical operation were required in the VSD group than the other two groups (p < 0.001). The treatment cost in the VSD group was higher than the MIVD group (p = 0.045) and the Penrose group (p < 0.001). Conclusions In the treatment of severe multi-space DFI in head and neck, MIVD and VSD are superior to the Penrose drain in infection control and reduction in clinicians' workload. Meanwhile, MIVD, with fewer surgical procedures required and less cost, seems to be a more promising method than VSD.
C1 [Qian, Yuanyi; He, Di; Qi, HaoZhao; Zhang, Tian; Fu, Tao; Yu, Menghua; Yan, Qin; Cai, Zhuoying; Liu, Yanming] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Oral & Maxillofacial Surg, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
C3 Zhejiang University
RP Liu, YM (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Oral & Maxillofacial Surg, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
EM liuyanming@zju.edu.cn
OI , Yuanyi/0000-0002-0001-4221
FU Fund of Basic Public Welfare Research Program of Zhejiang Province
   [LGF21H140002]; Joint Foundation for Key Program of Medical Health
   Science and Technology Project of Zhejiang Provincial Health Commission;
   National Health and Family Planning Commission of the People's Republic
   of China [WKJ-ZJ-1718]
FX This study was supported by the Fund of Basic Public Welfare Research
   Program of Zhejiang Province (LGF21H140002) and Joint Foundation for Key
   Program of Medical Health Science and Technology Project of Zhejiang
   Provincial Health Commission and National Health and Family Planning
   Commission of the People's Republic of China (WKJ-ZJ-1718).
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NR 25
TC 6
Z9 7
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2022
VL 46
IS 12
BP 2973
EP 2983
DI 10.1007/s00268-022-06758-9
EA OCT 2022
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Y1GG
UT WOS:000865711900002
PM 36216895
DA 2026-07-24
ER

PT J
AU De Coster, A
AF De Coster, A.
TI Linking challenges in wound healing: key highlights from the Hartmann
   congress
SO JOURNAL OF WOUND CARE
LA English
DT Article
ID MANAGEMENT
AB With a special focus on advanced wound healing (wound bed preparation, epithelialisation and hydration) and negative pressure wound therapy, the Hartmann LINK for Wound Healing Congress took place in Belfast, Northern Ireland, on 19 September. The event aimed to promote the latest advances in wound care and highlight the main challenges that clinicians face when treating different types of wounds.
CR Clokie M, 2017, DIABETIC MED, V34, P305, DOI 10.1111/dme.13313
   Game FL, 2016, PLAST RECONSTR SURG, V138, p158S, DOI 10.1097/PRS.0000000000002681
   Geiger SE, 2016, WOUNDS, V28, P306
NR 3
TC 1
Z9 1
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2017
VL 26
IS 11
BP 696
EP 698
PG 2
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FL5VA
UT WOS:000414312600011
PM 29131747
DA 2026-07-24
ER

PT J
AU Lai, RD
   Yan, SJ
   Wang, SJ
   Yang, SQ
   Yan, ZR
   Lan, P
   Wang, YG
   Li, Q
   Wang, JL
   Wang, W
   Ma, YF
   Liang, ZJ
   Zhang, JF
   Zhou, N
   Han, XT
   Zhang, XC
   Zhang, M
   Zhao, XD
   Zhang, GQ
   Zhu, HD
   Yu, XZ
   Lyu, CZ
AF Lai, Rongde
   Yan, Shijiao
   Wang, Shijun
   Yang, Shuqing
   Yan, Zhangren
   Lan, Pin
   Wang, Yonggao
   Li, Qi
   Wang, Jinlong
   Wang, Wei
   Ma, Yuefeng
   Liang, Zijing
   Zhang, Jianfeng
   Zhou, Ning
   Han, Xiaotong
   Zhang, Xinchao
   Zhang, Mao
   Zhao, Xiaodong
   Zhang, Guoqiang
   Zhu, Huadong
   Yu, Xuezhong
   Lyu, Chuanzhu
TI The Chinese guideline for management of snakebites
SO WORLD JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE Snakebite; Envenomation; Management; Prevention
ID PRESSURE WOUND THERAPY; FRESH-FROZEN PLASMA;
   PROTOBOTHROPS-MUCROSQUAMATUS BITE; RANDOMIZED CONTROLLED-TRIAL; VACUUM
   SEALING DRAINAGE; EARLY ADVERSE-REACTIONS; ORAL BACTERIAL-FLORA;
   ANTIVENOM USE; LOWER-LIMB; VENOM
AB In 2009, the World Health Organization included snakebite on the list of neglected tropical diseases, acknowledging it as a common occupational hazard for farmers, plantation workers, and others, causing tens of thousands of deaths and chronic physical disabilities every year. This guideline aims to provide practical information to help clinical professionals evaluate and treat snakebite victims. These recommendations are based on clinical experience and clinical research evidence. This guideline focuses on the following topics: snake venom, clinical manifestations, auxiliary examination, diagnosis, treatments, and prevention.
C1 [Lai, Rongde; Wang, Wei; Liang, Zijing] Guangzhou Med Univ, Affiliated Hosp 1, Emergency Dept, Guangzhou 510120, Peoples R China.
   [Yan, Shijiao] Hainan Med Univ, Sch Publ Hlth, Haikou 571199, Peoples R China.
   [Wang, Shijun] Fujian Univ Tradit Chinese Med, Affiliated Peoples Hosp, Surg Dept Tradit Chinese Med, Fuzhou 350004, Peoples R China.
   [Yang, Shuqing] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Emergency Dept, Chongqing 400014, Peoples R China.
   [Yan, Zhangren] Jiangxi Univ Chinese Med, Affiliated Hosp, Dept Surg Tradit Chinese Med, Nanchang 330006, Peoples R China.
   [Lan, Pin] Wenzhou Med Univ, Zhejiang Univ, Affiliated Hosp 5, Lishui Hosp,Lishui Cent Hosp,Dept Emergency Med, Lishui 323000, Peoples R China.
   [Wang, Yonggao] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Gen Surg Dept, Hangzhou 310006, Peoples R China.
   [Li, Qi] Fujian Med Univ, Shengli Clin Med Coll, Emergency Dept, Fuzhou 350001, Peoples R China.
   [Wang, Jinlong] Chongqing Univ, Fuling Hosp, Emergency Dept, Chongqing 408000, Peoples R China.
   [Wang, Wei] Guangxi Med Univ, Affiliated Hosp 1, Emergency Dept, Nanning, Peoples R China.
   [Ma, Yuefeng; Zhang, Mao] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Emergency Dept, Hangzhou 310009, Peoples R China.
   [Liang, Zijing] Guangzhou Med Univ, Affiliated Hosp 1, Emergency Dept, Guangzhou 510120, Peoples R China.
   [Zhang, Jianfeng] Guangxi Med Univ, Wuming Hosp, Emergency Dept, Nanning 530021, Peoples R China.
   [Zhou, Ning] Cent Peoples Hosp Zhanjiang, Emergency Dept, Zhanjiang 524037, Peoples R China.
   [Han, Xiaotong] Hunan Prov Peoples Hosp, Emergency Dept, Changsha 410005, Peoples R China.
   [Zhang, Xinchao] Beijing Hosp, Natl Geriatr Ctr, Emergency Dept, Beijing 100020, Peoples R China.
   [Zhao, Xiaodong] Peoples Liberat Army Gen Hosp, Med Ctr 4, Emergency Dept, Beijing 100048, Peoples R China.
   [Zhang, Guoqiang] China Japan Friendship Hosp, Emergency Dept, Beijing 100029, Peoples R China.
   [Zhu, Huadong; Yu, Xuezhong] Peking Union Med Coll Hosp, Emergency Dept, Beijing 100730, Peoples R China.
   [Lyu, Chuanzhu] Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Emergency Dept, Chengdu 610072, Peoples R China.
   [Lyu, Chuanzhu] Hainan Med Univ, Chinese Acad Med Sci No 2019RU013, Res Unit Isl Emergency Med, Haikou 571199, Peoples R China.
C3 Guangzhou Medical University; Hainan Medical University; Fujian
   University of Traditional Chinese Medicine; Chongqing University;
   Jiangxi University of Traditional Chinese Medicine; Zhejiang University;
   Wenzhou Medical University; Zhejiang Chinese Medical University; Fujian
   Medical University; Chongqing University; Guangxi Medical University;
   Zhejiang University; Guangzhou Medical University; Guangxi Medical
   University; Beijing Hospital; Chinese People's Liberation Army General
   Hospital; China-Japan Friendship Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
   Hospital; Sichuan Provincial People's Hospital; Hainan Medical
   University
RP Lai, RD; Liang, ZJ (通讯作者)，Guangzhou Med Univ, Affiliated Hosp 1, Emergency Dept, Guangzhou 510120, Peoples R China.; Ma, YF; Zhang, M (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Emergency Dept, Hangzhou 310009, Peoples R China.; Liang, ZJ (通讯作者)，Guangzhou Med Univ, Affiliated Hosp 1, Emergency Dept, Guangzhou 510120, Peoples R China.; Zhang, JF (通讯作者)，Guangxi Med Univ, Wuming Hosp, Emergency Dept, Nanning 530021, Peoples R China.; Zhou, N (通讯作者)，Cent Peoples Hosp Zhanjiang, Emergency Dept, Zhanjiang 524037, Peoples R China.; Han, XT (通讯作者)，Hunan Prov Peoples Hosp, Emergency Dept, Changsha 410005, Peoples R China.; Zhang, XC (通讯作者)，Beijing Hosp, Natl Geriatr Ctr, Emergency Dept, Beijing 100020, Peoples R China.; Zhao, XD (通讯作者)，Peoples Liberat Army Gen Hosp, Med Ctr 4, Emergency Dept, Beijing 100048, Peoples R China.; Zhang, GQ (通讯作者)，China Japan Friendship Hosp, Emergency Dept, Beijing 100029, Peoples R China.; Zhu, HD; Yu, XZ (通讯作者)，Peking Union Med Coll Hosp, Emergency Dept, Beijing 100730, Peoples R China.; Lyu, CZ (通讯作者)，Sichuan Prov Peoples Hosp, Sichuan Acad Med Sci, Emergency Dept, Chengdu 610072, Peoples R China.; Lyu, CZ (通讯作者)，Hainan Med Univ, Chinese Acad Med Sci No 2019RU013, Res Unit Isl Emergency Med, Haikou 571199, Peoples R China.
EM lairongde@163.com; 2193017@zju.edu.cn; 13719337897@163.com;
   zhangjf.gxmu@163.com; zjzhou121@163.com; 744953695@qq.com;
   xinchaoz@163.com; z2jzk@zju.edu.cn; zxd63715@126.com;
   zhangchong2003@vip.sina.com; zhuhuadong1970@126.com; yxzpumch@126.com;
   lvchuanzhu677@126.com
RI ; Zhang, Jianfeng/HLG-5337-2023
OI Zhang, Guo Qiang/0000-0003-1728-3847; Liang, Qing/0009-0007-2863-5197; 
FU National Science Foundation of China [82160647]; Hainan Clinical Medical
   Research Center Project [LCYX202310]; Hainan Provincial Major Science
   and Technology Projects [ZDKJ202004]; CAMS Innovation Fund for Medical
   Sciences [2019-I2M-5-023]
FX Funding: This study was supported by the National Science Foundation of
   China (82160647) , Hainan Clinical Medical Research Center Project
   (LCYX202310) , Hainan Provincial Major Science and Technology Projects
   (ZDKJ202004) , and CAMS Innovation Fund for Medical Sciences
   (2019-I2M-5-023) .
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NR 160
TC 18
Z9 20
U1 7
U2 20
PU ZHEJIANG UNIV PRESS
PI Hangzhou
PA Xixi Campus, Zhejiang University, No. 148 Tianmushan Road, Hangzhou,
   Zhejiang, PEOPLES R CHINA
SN 1920-8642
J9 WORLD J EMERG MED
JI World J. Emerg. Med.
PD SEP
PY 2024
VL 15
IS 5
BP 333
EP 355
DI 10.5847/wjem.j.1920-8642.2024.076
PG 23
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA J9U1M
UT WOS:001340432500011
PM 39290598
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Sezai, A
   Unosawa, S
   Taoka, M
   Osaka, S
   Kitazumi, Y
   Suzuki, K
   Nakai, T
   Tanaka, M
AF Sezai, Akira
   Unosawa, Satoshi
   Taoka, Makoto
   Osaka, Shunji
   Kitazumi, Yoshiki
   Suzuki, Keito
   Nakai, Toshiko
   Tanaka, Masashi
TI New Treatment for Driveline Infection Following Implantation of a
   Ventricular Assist Device
SO HEART SURGERY FORUM
LA English
DT Article
AB In patients with an implantable ventricular assist device (VAD), driveline infection (DLI) is a challenging complication. Once DLI occurs, it may lead to pump contamination and/or septicemia, which means that early treatment is essential. We hereby report our initial experiences of a mechanically-powered portable negative pressure wound therapy system (Smart Negative Pressure: SNaPTM) to treat DLI at an outpatient clinic.
C1 [Sezai, Akira; Unosawa, Satoshi; Taoka, Makoto; Osaka, Shunji; Kitazumi, Yoshiki; Suzuki, Keito; Nakai, Toshiko; Tanaka, Masashi] Nihon Univ, Sch Med, Dept Cardiol, Dept Cardiovasc Surg, Tokyo, Japan.
C3 Nihon University
RP Sezai, A (通讯作者)，Nihon Univ, Sch Med, Dept Cardiovasc Surg, Itabashi Ku, 30-1 Oyaguchi Kamimachi, Tokyo 1738610, Japan.
EM asezai.med@gmail.com
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NR 9
TC 3
Z9 7
U1 0
U2 0
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2020
VL 23
IS 2
BP E132
EP E134
DI 10.1532/hsf.2899
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA LK7TC
UT WOS:000531063500009
PM 32364899
OA gold
DA 2026-07-24
ER

PT J
AU Said, SM
   Daly, RC
AF Said, Sameh M.
   Daly, Richard C.
TI Healing High-Risk Sternotomy Incisions: Interrupted Suture Closure and
   Negative Pressure Wound Therapy
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID INFECTIONS; MANAGEMENT
AB High-risk sternotomy incisions represent a challenge at the time of wound closure. We present an alternate wound closure technique that can be used in high-risk sternotomy incisions and consists of a combination of space-obliterating sutures and negative pressure (suction using wound VAC) therapy. doi: 10.1111/jocs.12388 (J Card Surg 2015;30:346-350)
C1 [Said, Sameh M.; Daly, Richard C.] Mayo Clin, Div Cardiovasc Surg, Rochester, MN USA.
C3 Mayo Clinic
RP Daly, RC (通讯作者)，200 First St,SW, Rochester, MN 55905 USA.
EM rdaly@mayo.edu
RI Said, Sameh/GPX-2127-2022
OI Said, Sameh/0000-0003-2193-0314
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   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
NR 10
TC 2
Z9 2
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD APR
PY 2015
VL 30
IS 4
BP 346
EP 350
DI 10.1111/jocs.12388
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CF4BV
UT WOS:000352494400008
PM 24943468
DA 2026-07-24
ER

PT J
AU Webster, J
   Scuffham, P
   Sherriff, KL
   Stankiewicz, M
   Chaboyer, WP
AF Webster, Joan
   Scuffham, Paul
   Sherriff, Karen L.
   Stankiewicz, Monica
   Chaboyer, Wendy P.
TI Negative pressure wound therapy for skin grafts and surgical wounds
   healing by primary intention
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; CONTROLLED-TRIAL; CLINICAL-TRIAL; EFFICACY;
   DEHISCENCE; EXPERIENCE; MANAGEMENT; INFECTION; FOOT; HIP
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broadening with a range of systems on the market, including those designed for use on clean, closed incisions and skin grafts. Reviews have concluded that the evidence for the effectiveness of NPWT remains uncertain. However, this is a rapidly evolving therapy. Consequently, a systematic review of the evidence for the effects of NPWT on postoperative wounds expected to heal by primary intention is required.
   Objectives
   To assess the effects of NPWT on surgical wounds (primary closure or skin grafting) that are expected to heal by primary intention.
   Search methods
   We searched the following electronic databases to identify reports of relevant randomised clinical trials: the Cochrane Wounds Group Specialised Register (searched 11 November 2011); the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Database of Abstracts of Reviews of Effects (T h e Coch ran e Library 2011, Issue 4); Ovid MEDLINE (2005 to October Week 4 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations 8 November 2011); Ovid EMBASE (2009 to 2011 Week 44); and EBSCOCINAHL (1982 to 04 November 2011). We conducted a separate search to identify economic evaluations.
   Selection criteria
   We included trials if they allocated patients at random and compared NPWT with any other type of wound dressing or compared one type of NPWT with a different type of NPWT.
   Data collection and analysis
   We assessed trials for their appropriateness for inclusion and for their quality. This was done by three review authors working independently, using pre-determined inclusion and quality criteria.
   Main results
   We included five eligible trials with a total of 280 participants. Two trials involved skin grafts and three acute wounds. Only one of the five trials reported the proportion of wounds completely healed and in this study all wounds healed. All five studies reported adverse events. In the four trials that compared standard dressings with negative pressure wound therapy (NPWT) the adverse event rate was similar between groups (negative pressure 33/86; standard dressing 37/103); risk ratio (RR) 0.97 (95% confidence intervals (CI) 0.33 to 2.89). There was significant heterogeneity for this result, due to the high incidence of fracture blisters in the NPWT group in one trial. One trial (87 participants) compared a commercial negative pressure device VAC (R) system with a negative pressure system developed in the hospital (GSUC). The adverse event rate was lower in the GSUC group (VAC (R) 3/42; GSUC 0/45); the RR was 0.13 (95% CI 0.01 to 2.51). Results indicate uncertainty about the true effect of either method on adverse events. The mean cost to supply equipment for VAC (R) therapy was USD 96.51/day compared to USD 4.22/day for the GSUC therapy (P = 0.01). Labour costs for dressing changes were similar. Pain intensity score was also reported to be lower in the GSUC group when compared with the VAC (R) group (p = 0.02)
   Authors' conclusions
   Evidence for the effectiveness of NPWT on complete healing of wounds expected to heal by primary intention remains unclear. Rates of graft loss may be lower when NPWT is used; but evidence to date suggests that hospital-based products are as effective in this area as commercial applications. There are clear cost benefits when non-commercial systems are used to create the negative pressure required for wound therapy, with no reduction in clinical outcome. Pain levels are also rated lower when hospital systems are compared with their commercial counterparts. The high incidence of blisters occurring when NPWT is used following orthopaedic surgery suggests that the therapy should be limited until safety in this population is established. Given the cost and widespread use of NPWT, there is an urgent need for suitably powered, high-quality trials to evaluate the effects of the newer NPWT products that are designed for use on clean, closed surgical incisions. Such trials should focus initially on wounds that may be difficult to heal, such assternal wounds or surgeries for obese patients.
C1 [Webster, Joan] Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Brisbane, Qld, Australia.
   [Webster, Joan; Sherriff, Karen L.; Chaboyer, Wendy P.] Griffith Univ, NHMRC Ctr Res Excellence Nursing, Brisbane, Qld 4111, Australia.
   [Webster, Joan] Univ Queensland, Sch Nursing & Midwifery, Brisbane, Qld, Australia.
   [Scuffham, Paul] Griffith Univ, Meadowbrook, Qld 4131, Australia.
   [Stankiewicz, Monica] Royal Brisbane & Womens Hosp, Specialist Outpatient Dept, Herston, Qld, Australia.
C3 Royal Brisbane & Women's Hospital; Griffith University; University of
   Queensland; Griffith University; Royal Brisbane & Women's Hospital
RP Webster, J (通讯作者)，Royal Brisbane & Womens Hosp, Ctr Clin Nursing, Brisbane, Qld, Australia.
EM joan_webster@health.qld.gov.au
RI ; Chaboyer, Wendy/F-9588-2018; Scuffham, Paul/B-3066-2014
OI Stankiewicz, Monica/0000-0003-3970-071X; Chaboyer,
   Wendy/0000-0001-9528-7814; Scuffham, Paul/0000-0001-5931-642X
FU Royal Brisbane and Women's Hospital, Australia; Griffith University,
   Australia; NIHR/Department of Health (England), (Cochrane Wounds Group),
   UK
FX Internal sourcesRoyal Brisbane and Women's Hospital, Australia. Time to
   conduct reviewGriffith University, Australia. Time to conduct
   reviewExternal sourcesNIHR/Department of Health (England), (Cochrane
   Wounds Group), UK.
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NR 76
TC 63
Z9 71
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2012
IS 4
AR CD009261
DI 10.1002/14651858.CD009261.pub2
PG 46
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 928US
UT WOS:000303012500001
PM 22513974
DA 2026-07-24
ER

PT J
AU de Weerd, L
   Kjæve, J
   Gurgia, L
   Weum, S
AF de Weerd, L.
   Kjaeve, J.
   Gurgia, L.
   Weum, S.
TI A large abdominal intercostal hernia in a patient with vascular type
   Ehlers-Danlos syndrome: a surgical challenge
SO HERNIA
LA English
DT Article; Proceedings Paper
CT Conference on Abdominal Wall Reconstruction
CY JUN 25-27, 2009
CL Washington, DC
DE Abdominal wall reconstruction; Abdominal intercostal hernia; Vacuum
   assisted closure system
ID REPAIR
AB A patient with vascular type Ehlers-Danlos syndrome developed a large abdominal intercostal hernia secondary to coughing. The tissue friability and associated risks for arterial ruptures and visceral perforations in these patients make hernia repair challenging. The hernia was successfully treated using a novel approach.
C1 [de Weerd, L.; Gurgia, L.] Univ Hosp N Norway, Dept Plast Surg & Hand Surg, N-9038 Tromso, Norway.
   [Kjaeve, J.] Univ Hosp N Norway, Dept Gastrointestinal Surg, N-9038 Tromso, Norway.
   [Weum, S.] Univ Hosp N Norway, Dept Radiol, N-9038 Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso; University Hospital of
   North Norway; UiT The Arctic University of Tromso; University Hospital
   of North Norway
RP de Weerd, L (通讯作者)，Univ Hosp N Norway, Dept Plast Surg & Hand Surg, Sykehusveien 38, N-9038 Tromso, Norway.
EM louis.deweerd@unn.no
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NR 13
TC 17
Z9 21
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD FEB
PY 2012
VL 16
IS 1
BP 117
EP 120
DI 10.1007/s10029-010-0721-9
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 881WL
UT WOS:000299521900018
PM 20848297
OA hybrid
DA 2026-07-24
ER

PT J
AU Durai, R
   Mownah, A
   Ng, PCH
AF Durai, R.
   Mownah, A.
   Ng, P. C. H.
TI Bridge vacuum-assisted closure: a novel technique of using a single
   vacuum machine for multiple adjacent wounds
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID THERAPY; INJURIES
AB Aims: To describe a simple method of applying the VAC dressing to multiple wounds. Methods: Applying a VAC dressing using a sponge bridge to allow the simultaneous treatment of multiple wounds. Results: Successful healing was achieved using this simple method. Conclusion: The use of a simple sponge bridge allowed the simultaneous treatment of two adjacent wounds.
C1 [Durai, R.; Mownah, A.; Ng, P. C. H.] Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
C3 University of London; King's College London
RP Durai, R (通讯作者)，Lewisham Hosp NHS Trust, Lewisham High St, London SE13 6LH, England.
EM dr_durai@yahoo.com
CR Banwell PE, 2002, BRIT J PLAST SURG, V55, P264, DOI 10.1054/bjps.2001.3819
   Brown KM, 2001, ANN THORAC SURG, V72, P1409, DOI 10.1016/S0003-4975(01)02844-2
   Durai Rajaraman, 2008, J Perioper Pract, V18, P437
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 5
TC 4
Z9 4
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1368-5031
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JAN
PY 2010
VL 64
IS 1
BP 93
EP 94
DI 10.1111/j.1742-1241.2009.02007.x
PG 2
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 531HR
UT WOS:000272655800016
PM 20089017
DA 2026-07-24
ER

PT J
AU Kirkby, KA
   Wheeler, JL
   Farese, JP
   Ellison, GW
   Bacon, NJ
   Sereda, CW
   Lewis, DD
AF Kirkby, Kristin A.
   Wheeler, Jason L.
   Farese, James P.
   Ellison, Gary W.
   Bacon, Nicholas J.
   Sereda, Colin W.
   Lewis, Daniel D.
TI Vacuum-Assisted Wound Closure: Application and Mechanism of Action
SO COMPENDIUM-CONTINUING EDUCATION FOR VETERINARIANS
LA English
DT Article
AB Vacuum-assisted closure (VAC) is a wound management therapy that creates local negative pressure over a wound bed to promote healing. Benefits of VAC therapy include removal of fluid from the extravascular space, improved circulation, enhanced granulation tissue formation, increased bacterial clearance, and hastening of wound closure. This article describes the mechanism of action of VAC therapy, reviews application techniques, and lists potential complications and contraindications.
C1 [Kirkby, Kristin A.; Wheeler, Jason L.; Farese, James P.; Ellison, Gary W.; Bacon, Nicholas J.; Sereda, Colin W.; Lewis, Daniel D.] Univ Florida, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Kirkby, KA (通讯作者)，Univ Florida, Gainesville, FL 32611 USA.
OI Bacon, Nicholas/0000-0001-5190-5342
NR 0
TC 5
Z9 5
U1 0
U2 1
PU VETERINARY LEARNING SYSTEMS
PI YARDLEY
PA 780 TOWNSHIP LINE RD, YARDLEY, PA 19067-4200 USA
SN 1940-8307
J9 COMPENDIUM
JI Compendium
PD DEC
PY 2009
VL 31
IS 12
BP 568
EP +
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 539VQ
UT WOS:000273287200004
DA 2026-07-24
ER

PT J
AU Pearce, FB
   Richardson, KA
AF Pearce, F. B., Jr.
   Richardson, K. A.
TI Negative pressure wound therapy, staged excision and definitive closure
   with split-thickness skin graft for axillary hidradenitis suppurativa: a
   retrospective study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hidradenitis suppurativa; split-thickness skin graft; negative pressure
   wound therapy
AB Objective: Bilateral axillary hidradenitis is a chronic, suppurative, and scarring disease that is most effectively treated by complete excision of all hair-bearing tissues. We assessed our staged procedure for excision and placement of a split-thickness skin graft for bilateral axillary hidradenitis in terms of costs, outcomes, and timing of excision.
   Method: An IRB approved retrospective case analysis was performed on patients that underwent bilateral axillary hidradenitis skin excision with eventual placement of split-thickness skin grafting using the current LSUHSC/University Health hidradenitis surgical treatment protocol. Using ICD-9 codes (705.83) and CPT codes (11041, 11042, 11451, 11600, 11601, 11602, 11603, 11604) we reviewed cases performed at our institution from 1 January 2008 to 24 Febuary 2014 and we selected patients based on bilateral axillary involvement (alone) and > 1 year history of active disease. Patients were excluded if resection of tissue encompassed regions outside of the immediately adjacent axillary.
   Results: A total of seven patients matching criteria for bilateral axillary hidradenitis were selected for analysis. Clinical course, cost, and surgical techniques were assessed. Of the seven patients, six required admission throughout their treatment due to lack of funding making use of negative pressure wound therapy at home not possible. These patients stayed an average of 10 days with a mean hospital charge of $35,178 and a mean hospital provider charge of $10,019. No recurrence was demonstrated. All patients attained full range of motion, post grafting. No patient required a further operation due to graft failure.
   Conclusion: Split-thickness skin grafting without use of bilayer dermal regenerative templates yielded definitive results with acceptable cosmesis and functionality, without the added cost of treatments such as a bilayer dermal regenerative template.
C1 [Pearce, F. B., Jr.; Richardson, K. A.] Louisiana State Univ, Hlth Sci Ctr LSUHSC, Dept Gen Burn Surg, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University
RP Pearce, FB (通讯作者)，Louisiana State Univ, Hlth Sci Ctr LSUHSC, Dept Gen Burn Surg, Baton Rouge, LA 70803 USA.
EM fbpearce@gmail.com; kricha3@lsuhsc.edu
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   [Anonymous], FERRIS CLIN ADVISOR
   [Anonymous], CLIN DERMATOLOGY
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   Holtzman L.C., 2010, CLIN PROCEDURES EMER
   Layton A, 2010, OXFORD TXB MED
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   Townsend C.M., 2008, SABISTON TXB MODERN
   WATSON JD, 1985, BRIT J PLAST SURG, V38, P567, DOI 10.1016/0007-1226(85)90022-0
NR 10
TC 17
Z9 18
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2017
VL 26
IS 1
SU S
BP S36
EP S42
DI 10.12968/jowc.2017.26.Sup1.S36
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EI3XQ
UT WOS:000392426600005
PM 28105901
DA 2026-07-24
ER

PT J
AU Klein, RJ
AF Klein, Robert J.
TI Using Negative Pressure Wound Therapy With Instillation and Dwell Time
   to Create a Path to Closure for Older Patients With Chronic Wounds: A
   Retrospective Case Series
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time;
   chronic wound; podiatry; limb salvage; case series
ID BED PREPARATION
AB BACKGROUND: Chronic podiatric wounds are common causes of morbidity and mortality in older patients. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been recommended in wounds with high levels of exudate, contaminated wounds, and wounds in which healing progression has stalled. PURPOSE: This retrospective case series describes the use of NPWTi-d to prepare 4 chronic wounds for closure in older patients with multiple comorbidities. METHODS: Patients (N = 4) ranged in age from 65 to 95 years and had wounds present for at least 90 days. Previous treatments included conventional NPWT and debridement. NPWTi-d consisted of instillation of 10 to 20 mL normal saline, dwell time for 1 minute, followed by 3-hour cycles of -125 mm Hg. Antibiotics were administered as needed. Wounds included a 210-day Wagner grade 3 diabetic foot ulcer (3.2 x 1.8 x 0.3 cm(3)), a 90-day dehisced wound (9.5 x 2.6 x 0.4 cm(3)), a 300-day neuropathic ulcer (0.7 x 0.5 x 2.1 cm(3)), and a 150-day Wagner grade 2 diabetic foot ulcer (4.5 x 3.3 x 0.9 cm(3)). NPWTi-d was applied for 3 to 33 days, when care was transitioned to advanced wound dressings. RESULTS: All 4 wounds responded positively to therapy, exhibiting reduced slough, growing granulation tissue, and size reduction. Closure was achieved in all cases. CONCLUSION: In these 4 patients, NPWTi-d, used as part of a treatment regimen including debridement, antibiotics, and advanced wound dressings, was effective in creating an environment that promoted wound healing and prepared the wounds for eventual closure.
C1 [Klein, Robert J.] PRISMA Hlth Upstate, Wound Care, Greenville, SC USA.
C3 Prisma Health
RP Klein, RJ (通讯作者)，VHA Wound Healing & Hyperbar Oxygen Ctr, 200 Patewood Dr,Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Ahmed AF, 2012, J ADV RES, V3, P109, DOI 10.1016/j.jare.2011.05.004
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   Wicke C, 2009, WOUND REPAIR REGEN, V17, P25, DOI 10.1111/j.1524-475X.2008.00438.x
NR 13
TC 2
Z9 4
U1 4
U2 11
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD FEB
PY 2022
VL 68
IS 2
BP 16
EP 21
DI 10.25270/wmp.2022.2.1621
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 2B9QA
UT WOS:000810514500001
DA 2026-07-24
ER

PT J
AU Seswandhana, MR
   Humani, HMA
   Gabriela, GC
   Dachlan, I
   Liana, E
   Wirohadidjojo, YW
   Aryandono, T
   Mulyono, B
   Widodo, I
AF Seswandhana, Muhammad Rosadi
   Humani, Hamim Majdy Awliya
   Gabriela, Gita Christy
   Dachlan, Ishandono
   Liana, Estelita
   Wirohadidjojo, Yohanes Widodo
   Aryandono, Teguh
   Mulyono, Budi
   Widodo, Irianiwati
TI The impact of negative pressure wound therapy on epidermal stem cells
   and keratinocyte growth factor in deep dermal burn injury: An
   experimental study
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Wound healing; Burn management;
   Burn injury; Epidermal stem cell (ESC)
AB Introduction: Burns are the fourth most common accidental injury worldwide, predominantly occurring in developing countries. Wound healing in burns involves reduced cytokine secretion but increased chemokine and growth factor production compared to surgical wounds. Keratinocyte growth factor (KGF) regulates epidermal regeneration, an essential process in wound healing; while epidermal stem cells (ESCs) play a crucial role in wound closure and have potential for cell therapy. Negative pressure wound therapy (NPWT) promotes healing by improving blood flow, enhancing re-epithelialization, and reducing infection risk. This study investigates the effects of NaCl 0.9 %, intermittent and continuous NPWT, and silver sulfadiazine on ESC and KGF levels in deep dermal burns. Method: Six male Yorkshire pigs received 20 deep dermal burns on the flank and dorsum, divided into four treatment groups: NaCl 0.9 %, continuous NPWT, intermittent NPWT, and silver sulfadiazine. Samples were collected on days 1, 3, 7, 14, and 21. ESCs were evaluated using CK19 immunohistochemistry as a marker. KGF levels were measured via ELISA. Data were analyzed with ANOVA, with significance set at p < 0.05. Result: Continuous NPWT showed the highest ESC counts at the wound edge on all observation days and at the wound center on days 3 and 21, though without statistical significance. KGF levels differed significantly among the groups on days 1, 3, and 7 (p < 0.05), with the continuous NPWT group consistently showing the highest KGF levels. Statistical analysis revealed that treatment, observation day, and KGF levels significantly influenced ESC counts, accounting for 45 % of the variability (p < 0.05). Conclusion: The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings.
C1 [Seswandhana, Muhammad Rosadi; Humani, Hamim Majdy Awliya; Gabriela, Gita Christy; Dachlan, Ishandono; Liana, Estelita] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Div Plast Reconstruct & Aesthet Surg, Dept Surg ,Fac Med, Yogyakarta 55281, Indonesia.
   [Wirohadidjojo, Yohanes Widodo] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Fac Med, Dept Dermatol & Venerol, Yogyakarta 55281, Indonesia.
   [Aryandono, Teguh] Univ Gadjah Mada, Dr Sardjito Hosp, Fac Med Publ Hlth & Nursing, Dept Clin Pathol, Yogyakarta 55281, Indonesia.
   [Mulyono, Budi] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Dept Clin Pathol, Fac Med, Yogyakarta 55281, Indonesia.
   [Widodo, Irianiwati] Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Dept Anat Pathol, Dept Surg,Fac Med, Yogyakarta 55281, Indonesia.
C3 Central General Hospital Dr. Sardjito; Central General Hospital Dr.
   Sardjito; Gadjah Mada University; Central General Hospital Dr. Sardjito;
   Central General Hospital Dr. Sardjito; Central General Hospital Dr.
   Sardjito
RP Seswandhana, MR (通讯作者)，Dr Sardjito Hosp, Publ Hlth & Nursing Univ Gadjah Mada, Div Plast Reconstruct & Aesthet Surg, Dept Surg ,Fac Med, Yogyakarta 55281, Indonesia.
EM rosadi_seswandhana@ugm.ac.id
RI Seswandhana, Rosadi/AAH-4064-2020
OI Seswandhana, Rosadi/0000-0002-5138-7802
FU Universitas Gadjah Mada [280/UN1/FK-KMK/PP/PT/2020]
FX The author (s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by research grants from Universitas Gadjah Mada. Number:
   280/UN1/FK-KMK/PP/PT/2020.
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NR 30
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2025
VL 51
IS 9
AR 107719
DI 10.1016/j.burns.2025.107719
EA OCT 2025
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 8PO7V
UT WOS:001594286500001
PM 41061528
DA 2026-07-24
ER

PT J
AU Lumsden, EJ
   Kimble, RM
   Ware, RS
   Griffin, B
AF Lumsden, Emma J.
   Kimble, Roy M.
   Ware, Robert S.
   Griffin, Bronwyn
TI The impact of decreasing acute burn re-epithelialisation time utilising
   Negative Pressure Wound Therapy on morbidity: A modelled, retrospective
   cohort study
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Burn; Paediatric; Re-epithelialisation;
   Depth
AB Introduction: Negative pressure wound therapy (NPWT) that is applied to an acute, paediatric burn at the initial debridement may decrease re-epithelialisation time by approximately 22 %. The clinical significance of this reduction is unknown. In addition, the implication of burn variables such as depth in conjunction with NPWT have not been considered. The aim of this study was to model the effect NPWT may have on burn morbidity by reducing re-epithelialisation time by 22 % when stratified by depth. Methods: This modelled study used retrospective data from a single Australian quaternary paediatric burns unit. Data were from 2014-2016, the final period before NPWT was introduced into routine, acute burn care. Burn depths were defined as superficial partial thickness (SPT), deep dermal partial thickness (DPT), and full thickness (FT). The outcome was the effect reducing time to re-epithelialisation by 22 % had on therapeutic morbidity, stratified via depth. Results: Overall, 803 participants were included. The odds ratio of being referred to scar clinic increased by 7.6 (95 % CI 4.4-13.1; p <0.001) for each incremental increase in burn depth. For DPT burns, the mean time to reepithelialisation was 21.4 days (SE 0.7), and 134 (65.7 %) participants were referred to scar outpatient clinic. Modelled data demonstrated a 67.2 % (95 % CI 58.8-75.6) probability of scar outpatient clinic referral at day 21. When reducing re-epithelialisation time by 22 %, DPT burns re-epithelialised on day 16, which reduced the probability of scar outpatient clinic referral by 22.3 % (44.9 %, 95 % CI 35.6-54.3 %, p < 0.001). Reducing time to re-epithelialisation by 22 % had minimal impact on SPT and FT burn morbidity. Conclusion: The addition of NPWT as an acute, paediatric burn care adjunct is likely to have a clinically significant impact on DPT burn morbidity.
C1 [Lumsden, Emma J.; Kimble, Roy M.] Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Queensland Childrens Hosp, Dept Paediat Surg Urol Burns & Trauma, Stanley St, South Brisbane, Qld 4101, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Ctr Childrens Hlth Res, 62 Graham St, South Brisbane, Qld 4101, Australia.
   [Ware, Robert S.] Griffith Hlth, Griffith Biostat Unit, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Griffin, Bronwyn] Griffith Univ, Sch Nursing & Midwifery, Hlth Grp, Nathan, Qld 4111, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; Griffith University
RP Lumsden, EJ (通讯作者)，Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM emma.lumsden@health.qld.gov.au
RI ; Griffin, Bronwyn/AEB-6299-2022; Ware, Robert/B-2024-2014; Kimble,
   Roy/B-4160-2011
OI Luden, Emma/0000-0002-5437-9701; Griffin, Bronwyn/0000-0002-6182-9125;
   Ware, Robert/0000-0002-6129-6736; 
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NR 14
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD NOV
PY 2025
VL 51
IS 8
AR 107621
DI 10.1016/j.burns.2025.107621
EA JAN 2025
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 8MK0Z
UT WOS:001592126100001
PM 40834480
DA 2026-07-24
ER

PT J
AU Goldman, T
   Costa, B
AF Goldman, Theodore
   Costa, Ben
TI A Systematic Review and Meta-analysis of Two Negative Pressure Wound
   Therapy Devices to Manage Cesarean Section Incisions
SO AMERICAN JOURNAL OF PERINATOLOGY
LA English
DT Review
DE surgical site infection; obesity; cesarean section; negative pressure
   wound therapy; meta-analysis; systematic review
ID SURGICAL-SITE INFECTION; OBESE WOMEN; SKIN INCISION; RISK-FACTORS;
   DELIVERY; COMPLICATIONS; PREVENTION; PREGNANCY; IMPACT; COSTS
AB This paper aims to evaluate whether there is a device-dependent effect on the reduction of surgical site complications in obese patients (body mass index [BMI] >= 30 kg/m(2)) undergoing cesarean section ( C-section). PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched for the period, January 2011 to September 2021. English language articles describing a randomized controlled trial (RCT) that compared either a -80 or -125mm Hg single-use negative pressure wound therapy ( sNPWT) device to standard dressings in obese (BMI >= 30 kg/m(2)) patients undergoing C- section were included. Conference abstracts and "terminated" RCTs with published results were deemed eligible for inclusion. The primary outcome of interest was surgical site infection (SSI), classified as composite, superficial, or deep. Secondary outcomes assessed included seroma, dehiscence, hematoma, bleeding, reoperation, readmission, blistering, and (composite) wound complications. A total of 223 titles were identified, of which 129 were screened by full- text review. Eleven RCTs encompassing 5,847 patients met the inclusion criteria and were considered eligible for further analysis (-80mm Hg: six studies; -125mm Hg: five studies). A statistically significant improvement in the composite SSI (odds ratio [OR]: 0.69; 95% confidence interval [CI]: 0.54-0.89) and superficial SSI (OR: 0.66; 95% CI: 0.50-0.86) outcomes was observed with the -80mm Hg device, compared with standard dressings. The same effect on SSI outcomes was not observed with the -125mm Hg device ( composite SSI-OR: 0.91; 95% CI: 0.64- 1.28; superficial SSI-OR: 1.12; 95% CI: 0.70-1.78). There were no statistically significant differences in any of the other assessed outcomes. sNPWT devices may differ in their ability to reduce composite or superficial SSI after C-section.
C1 [Goldman, Theodore] Northwell Hlth, Obstet & Gynecol, Huntington, NY USA.
   [Costa, Ben] Smith??Nephew, Global Clin & Med Affairs, Kingston Upon Hull, England.
   [Costa, Ben] Smith Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
C3 Northwell Health; Smith & Nephew; Smith & Nephew
RP Costa, B (通讯作者)，Smith Nephew, Global Clin & Med Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
EM ben.costa@smith-nephew.com
OI Costa, Benedict/0000-0002-7132-2520
FU Smith amp; Nephew, Inc.
FX This study was funded by Smith & Nephew, Inc.
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   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
   Zaki MN, 2016, J PERINATOL, V36, P819, DOI 10.1038/jp.2016.89
   Zuarez-Easton S, 2017, INT J WOMENS HEALTH, V9, P81, DOI 10.2147/IJWH.S98876
NR 59
TC 4
Z9 7
U1 2
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0735-1631
EI 1098-8785
J9 AM J PERINAT
JI Am. J. Perinatol.
PD MAY
PY 2024
VL 41
SU 01
BP e2786
EP e2798
DI 10.1055/s-0043-1775562
EA SEP 2023
PG 13
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA UL4O5
UT WOS:001069583000005
PM 37726017
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Litchinko, A
   Ris, F
   Noiret, B
   Adamina, M
   Denost, Q
AF Litchinko, A.
   Ris, F.
   Noiret, B.
   Adamina, M.
   Denost, Q.
TI Evaluating negative-pressure wound therapy after abdominoperineal
   resection: a systematic review of efficacy and technical variability
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Review
DE Abdominoperineal resection; Prophylactic negative-pressure wound
   therapy; Perineal wound complications; Surgical site infection
ID LOW RECTAL-CANCER; INTERSPHINCTERIC RESECTION; EXCISION; COMPLICATIONS;
   INFECTIONS; MANAGEMENT; CLOSURE; IMPACT; RISK
AB BackgroundPerineal wound complications after abdominoperineal resection (APR) for anal or low rectal cancer remain a significant clinical concern, frequently leading to surgical site infections (SSIs), wound dehiscence, and delayed healing. These complications contribute to increased patient morbidity, prolonged hospitalization, and higher healthcare costs. Prophylactic negative pressure wound therapy (pNPWT) has been proposed to improve wound outcomes in this context, but evidence regarding its effectiveness remains inconclusive.ObjectiveThis systematic review evaluates the clinical outcomes and technical application of pNPWT in closed perineal wounds following APR, with a focus on its potential impact on SSIs, wound dehiscence, and healing time.MethodsA systematic literature search was conducted in MEDLINE, Embase, and the Cochrane Library in accordance with PRISMA guidelines. Eligible studies included randomized controlled trials and observational studies assessing pNPWT after APR. Key outcomes of interest were SSI rates, wound dehiscence, healing time, and length of hospital stay. Due to clinical and methodological heterogeneity, a narrative synthesis was performed.ResultsIn total, eight studies met the inclusion criteria. The results were heterogeneous: while three studies reported reduced SSI rates with pNPWT compared with conventional wound management, two studies observed higher SSI rates in the pNPWT groups. Variability in device type (canister-based versus portable systems), negative pressure settings, application duration, and patient selection limited the comparability across studies. The risk of bias was moderate to high in several studies, and outcome reporting was inconsistent.ConclusionsCurrent evidence does not allow for definitive conclusions regarding the clinical benefit of pNPWT after APR. While some studies suggest potential advantages, particularly in terms of SSI reduction, results remain inconsistent and device-dependent. Further high-quality randomized trials are required to clarify the role of pNPWT and to define optimal application protocols in this challenging surgical context.
C1 [Litchinko, A.; Adamina, M.] Univers Hosp Fribourg, Div Digest Surg, HFR Fribourg Cantonal Hosp, Chemin Pensionnat 2-6, CH-1752 Fribourg, Switzerland.
   [Litchinko, A.; Ris, F.; Adamina, M.] HFR Fribourg Cantonal Hosp, Fac Sci, CH-1711 Fribourg, Switzerland.
   [Litchinko, A.] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Noiret, B.; Denost, Q.] Bordeaux Colorectal Inst, 220 Rue Mandron, F-33300 Bordeaux, France.
C3 University of Geneva
RP Litchinko, A (通讯作者)，Univers Hosp Fribourg, Div Digest Surg, HFR Fribourg Cantonal Hosp, Chemin Pensionnat 2-6, CH-1752 Fribourg, Switzerland.; Litchinko, A (通讯作者)，HFR Fribourg Cantonal Hosp, Fac Sci, CH-1711 Fribourg, Switzerland.; Litchinko, A (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM alexis.litchinko@gmail.com
FU University of Fribourg
FX Open access funding provided by University of Fribourg. None.
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD SEP 23
PY 2025
VL 29
IS 1
AR 168
DI 10.1007/s10151-025-03212-5
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 7PY2G
UT WOS:001576875800001
PM 40987996
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Svensson-Björk, R
   Saha, S
   Acosta, S
   Gerdtham, UG
   Hasselmann, J
   Asciutto, G
   Zarrouk, M
AF Svensson-Bjork, Robert
   Saha, Sanjib
   Acosta, Stefan
   Gerdtham, Ulf-G
   Hasselmann, Julien
   Asciutto, Giuseppe
   Zarrouk, Moncef
TI Cost-effectiveness analysis of negative pressure wound therapy dressings
   after open inguinal vascular surgery - The randomised INVIPS-Trial
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Negative pressure wound therapy; Cost-effectiveness analysis;
   Prevention; Surgical site infection; Vascular surgery
ID SURGICAL SITE INFECTIONS; COMPLICATIONS; STANDARD; IMPACT
AB Aim: While the scientific evidence in favour of negative pressure wound therapy (NPWT) dressings on sutured incisions in the prevention of surgical site infections (SSIs) has increased, the cost-effectiveness after vascular surgery has not been evaluated. The aim of this study was to evaluate the cost-effectiveness of NPWT compared to standard dressings for the prevention of SSIs after open inguinal vascular surgery.
   Materials and methods: Patient data were retrieved from the randomised INVIPS-trial's open arm, which included patients randomised to either NPWT or standard dressings. The patients were surveyed for SSIs for 90 days postoperatively. The patients' individual cost data were included and analysed from a healthcare perspective. The patients' quality of life was measured using the Vascuqol-6 questionnaire pre- and 30 days postoperatively. Cost-effectiveness of NPWT was determined by decreased or equal total costs and a significant reduction in SSI incidence. Results: The mean vascular procedure-related costs at 90 days were (sic)16,621 for patients treated with NPWT (n = 59) and (sic)16,285 for patients treated with standard dressings (n = 60), p = 0.85. The SSI incidence in patients treated with NPWT was 11.9% (n = 7/59) compared to 30.0% (n = 18/60) with standard dressings, p = 0.015. This corresponds to an increased mean cost of (sic)1,853 per SSI avoided. The cost-effectiveness plane of incremental vascular procedure-related costs and difference in Vascuqol-6 score showed that 42% of estimates were in the quadrant where NPWT was dominant. Conclusion: NPWT is considered cost-effective over standard dressings in patients undergoing open inguinal vascular surgery due to reduced SSI incidence at no higher costs.
C1 [Svensson-Bjork, Robert; Acosta, Stefan; Hasselmann, Julien; Zarrouk, Moncef] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Svensson-Bjork, Robert; Acosta, Stefan; Hasselmann, Julien; Asciutto, Giuseppe; Zarrouk, Moncef] Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Malmo, Sweden.
   [Saha, Sanjib; Gerdtham, Ulf-G] Lund Univ, Dept Clin Sci, Hlth Econ Unit, Malmo, Sweden.
   [Gerdtham, Ulf-G] Lund Univ, Dept Econ, Lund, Sweden.
   [Asciutto, Giuseppe] Univ Hosp Muenster, Dept Vasc & Endovasc Surg, Munster, Germany.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Lund University; University of Munster
RP Svensson-Björk, R (通讯作者)，Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM Robert.Svensson_Bjork@med.lu.se
RI Hasselmann, Julien/C-1586-2015; Acosta, Stefan/JAX-3225-2023; Gerdtham,
   Ulf-Göran/I-6766-2018; Hasselmann, Julien/C-1586-2015
OI Acosta, Stefan/0000-0002-3225-0798; Gerdtham,
   Ulf-Göran/0000-0002-0647-7817; Hasselmann, Julien/0000-0003-4453-0292;
   Saha, Sanjib/0000-0001-8649-0773
FU Swedish Medical Research Council [2019-00435]; Skane University
   Hospital; Government Grant for Clinical Research (ALF); Region Skane;
   Swedish Research Council [2019-00435] Funding Source: Swedish Research
   Council
FX This study was made possible by unconditional grants from the Swedish
   Medical Research Council (Diary number 2019-00435) and Skane University
   Hospital. The Health Economics Program at Lund University also receives
   unconditional core funding from Government Grant for Clinical Research
   (ALF) and Region Skane (Gerdtham). The funding sources had no influence
   on any part of this study. The authors declare no conflict of interest.
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NR 29
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2021
VL 30
IS 1
BP 95
EP 101
DI 10.1016/j.jtv.2020.09.005
EA FEB 2021
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA QF2ER
UT WOS:000616712700014
PM 33046345
OA hybrid
DA 2026-07-24
ER

PT J
AU Delhougne, G
   Hogan, C
   Tarka, K
   Nair, S
AF Delhougne, Gary
   Hogan, Christopher
   Tarka, Kim
   Nair, Sunitha
TI A Retrospective, Cost-minimization Analysis of Disposable and
   Traditional Negative Pressure Wound Therapy Medicare Paid Claims
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE cost-minimization analysis; negative pressure wound therapy; durable
   medical equipment; disposable equipment
ID EVIDENCE-BASED RECOMMENDATIONS; DIABETIC FOOT ULCERS; INTERNATIONAL
   CONSENSUS; STEPS; CARE; BURDEN; HEALTH; TRIAL
AB Traditional negative pressure wound therapy (NPWT) systems are considered durable. The pump is designed for use by numerous patients over a period of several years. Recently developed smaller. disposable devices are designed for single-patient use. A retrospective analysis of 2012-2014 national Medicare claims data was used to examine payments associated with the use of traditional and disposable NPWT systems. Data extracted included NPWT episodes from the Limited Data Set Standard Analytic Files including the 5% sample for traditional NPWT and 100% sample for disposable NPWT. NPWT episodes were identified using claim service dates and billing codes. Mean costs per episode were compared and analyzed using chi-squared tests for comparisons between patients who received traditional and those who used disposable NPWT. For continuous variables, statistical significance was assessed using Mann-Whitney U tests. The data included traditional (n = 2938; mean age 66.6 years) and disposable (n = 3522; mean age 67.6 years) episodes for the 2 NPWT groups. Wound types differed for NPWT groups (P <.0001) and included surgical (1134 [39%] versus 764 [22%]), generic open (850 [29%] versus 342 [10%]), skin ulcers (561 [19%) versus 1301 [37%]), diabetic ulcers (240 [8%] versus 342 [10%]), and circulatory system wounds (105 [4%) versus 563 [16%]). Average payment amounts were $4650 +/- $2782 for traditional and $1532 +/- $1767 per disposable NPWT episode (P < .0001). Payment differences were not affected by wound or comorbidity characteristics. Using the 2016 rates, average payments were $3501 for traditional and $1564 for disposable NPWT. Considering the rate of NPWT use in the United States and the results of this study suggesting substantial potential cost savings, additional analyses and cost-effectiveness studies are warranted.
C1 [Delhougne, Gary] Smith & Nephew Inc, Hlth Econ, Ft Worth, TX USA.
   [Hogan, Christopher] Direct Res LLC, Vienna, VA USA.
   [Tarka, Kim] Smith & Nephew, Postacute Care, Ft Worth, TX USA.
   [Nair, Sunitha] Presence St Francis Hosp, Wound Healing Ctr, Evanston, IL USA.
C3 Smith & Nephew; Smith & Nephew
RP Delhougne, G (通讯作者)，Smith & Nephew Biotherapeut, 5600 Clearfork Main St,Suite 600, Ft Worth, TX 76109 USA.
EM Gary.Delhougne@Smith-Nephew.com
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NR 20
TC 13
Z9 14
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JAN
PY 2018
VL 64
IS 1
BP 26
EP 33
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GO1CW
UT WOS:000439686000004
PM 29406300
DA 2026-07-24
ER

PT J
AU Foley, MP
   Fahey, C
   Byrne, AM
   Leahy, R
   Dempsey, L
   Westby, D
   Walsh, SR
AF Power Foley, Megan
   Fahey, Ciara
   Byrne, Anne-Marie
   Leahy, Roisin
   Dempsey, Laura
   Westby, Daniel
   Walsh, Stewart R.
TI Prophylactic Incisional Negative Pressure wound therapy (NPWT) for major
   Amputations (PINTA): protocol for randomized controlled trial of
   single-use NPWT devices for closed-incision major lower extremity
   amputations
SO BJS OPEN
LA English
DT Article
DE surgical complications; peripheral arterial disease; diabetes mellitus;
   medical device
ID SURGICAL-SITE INFECTIONS; LOWER-LIMB AMPUTATION; RISK-FACTORS;
   COMPLICATIONS; PREVALENCE; MORTALITY
AB Background Major lower extremity amputations are frequently performed for end-stage peripheral arterial disease and progressive diabetic foot complications. Wound complications after amputation affect up to one-third of limbs. The patient cohort undergoing amputation are typically high risk for poor wound healing, often with unmodifiable risk factors in an urgent clinical setting. Incisional negative pressure wound therapy (NPWT) has been shown to reduce wound complications in other high-risk populations. This randomized controlled trial investigates whether prophylactic NPWT reduces wound complications in patients after major amputation compared with standard dry dressings.Methods This protocol describes a prospective, multicentre, randomized controlled trial with an internal pilot recruiting patients undergoing major lower extremity amputation for any indication. Limbs will be randomized to receive either a single-use NPWT device on their closed surgical incision or a dry dressing. The primary clinical outcome is the rate of wound complications. Secondary outcomes include reoperation rates, length of hospital stay, cost-effectiveness of NPWT, and patient-reported quality of life. Follow-up will continue to 6 months after surgery. The initial pilot phase has a recruitment target of 96 limbs, whereas an estimated 728 patients will be required to power a definitive trial adequately.Discussion This trial aims to supplement the existing poor-quality data on this important aspect of care and equip healthcare professionals to make cost-effective decisions regarding postoperative wound management.
   Protocol for a pragmatic randomized controlled trial comparing prophylactic negative pressure wound therapy devices with standard care for closed-incision major lower extremity amputations. Outcomes include composite wound complications at 30 days, patient-reported outcomes on quality of life and wound-related quality of life, and cost-effectiveness. Adequately powered to 90% with a target sample size of 728 patients.
C1 [Power Foley, Megan; Westby, Daniel; Walsh, Stewart R.] Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
   [Power Foley, Megan] Irish Surg Res Collaborat, Dublin, Ireland.
   [Fahey, Ciara; Byrne, Anne-Marie; Leahy, Roisin; Dempsey, Laura; Walsh, Stewart R.] Royal Coll Surgeons Ireland, Natl Surg Res Support Ctr, Dublin, Ireland.
   [Walsh, Stewart R.] Univ Galway, Lambe Inst Translat Res, Galway, Ireland.
C3 Royal College of Surgeons in Ireland - RCSI; Ollscoil na
   Gaillimhe-University of Galway
RP Foley, MP (通讯作者)，Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
EM meganpfoley@rcsi.com
RI Walsh, Stewart/AFZ-2791-2022
OI Walsh, Stewart/0000-0002-1006-9541; Power Foley,
   Megan/0000-0002-7731-3182
FU National Surgical Research Support Centre; Royal College of Surgeons in
   Ireland
FX Trial funding provided by National Surgical Research Support Centre at
   Royal College of Surgeons in Ireland. No funding was received by
   industry.
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NR 28
TC 0
Z9 0
U1 5
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD FEB
PY 2026
VL 10
IS 1
AR zraf159
DI 10.1093/bjsopen/zraf159
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AT2QI
UT WOS:001656224400001
PM 41504704
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Newman, JM
   Siqueira, MBP
   Klika, AK
   Molloy, RM
   Barsoum, WK
   Higuera, CA
AF Newman, Jared M.
   Siqueira, Marcelo B. P.
   Klika, Alison K.
   Molloy, Robert M.
   Barsoum, Wael K.
   Higuera, Carlos A.
TI Use of Closed Incisional Negative Pressure Wound Therapy After Revision
   Total Hip and Knee Arthroplasty in Patients at High Risk for Infection:
   A Prospective, Randomized Clinical Trial
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE revision; arthroplasty; wound healing; complications; infection;
   negative pressure wound therapy
ID SURGICAL SITE INFECTIONS; SHORT-TERM OUTCOMES; DRESSINGS; DRAINAGE;
   REPLACEMENT; SURGERY
AB Background: Continuous wound drainage after arthroplasty can lead to the development of a periprosthetic joint infection. Closed incisional negative pressure wound therapy (ciNPWT) has been reported to help alleviate drainage and other wound complications. The purpose of this prospective randomized controlled trial is to compare the use of ciNPWT with our standard of care dressing in revision arthroplasty patients who were at high risk to develop wound complications.
   Methods: A total of 160 patients undergoing elective revision arthroplasty were prospectively randomized to receive either ciNPWT or a silver-impregnated occlusive dressing after surgery in a single institution. Patients were included if they had at least 1 risk factor for developing wound complication(s): wound complication, readmission, and reoperation rates were collected at 2, 4, and 12 weeks postoperatively.
   Results: The postoperative wound complication rate was significantly higher in the control cohort compared to the ciNPWT cohort (19 [23.8%] vs 8 [10.1%], P = .022). There was no significant difference between the control and ciNPWT cohorts in terms of readmissions (19 [23.8%] vs 16 [20.3%], P = .595). Reoperation rate was higher in controls compared to ciNPWT patients (10 [12.5%] vs 2 [2.5%], P = .017). After adjusting for the history of a prior periprosthetic joint infection and inflammatory arthritis, the ciNPWT cohort had a significantly decreased wound complication rate (odds ratio 0.28, 95% confidence interval 0.11-0.68).
   Conclusion: ciNPWT may decrease the rate of postoperative wound complications in patients who are at an increased risk of such wound issues after revision arthroplasty. (C) 2019 The Authors. Published by Elsevier Inc.
C1 [Newman, Jared M.] Suny Downstate Med Ctr, Dept Orthopaed Surg, Brooklyn, NY 11203 USA.
   [Siqueira, Marcelo B. P.; Klika, Alison K.; Molloy, Robert M.] Cleveland Clin, Dept Orthopaed Surg, 9500 Euclid Ave A41, Cleveland, OH 44195 USA.
   [Barsoum, Wael K.; Higuera, Carlos A.] Cleveland Clin Florida, Dept Orthopaed Surg, Weston, FL USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Cleveland Clinic Foundation; Cleveland Clinic
   Foundation
RP Klika, AK (通讯作者)，Cleveland Clin, Dept Orthopaed Surg, 9500 Euclid Ave A41, Cleveland, OH 44195 USA.
FU KCI/Acelity Inc. (San Antonio, TX)
FX This study was funded by a research grant provided by KCI/Acelity Inc.
   (San Antonio, TX).
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NR 39
TC 101
Z9 103
U1 0
U2 9
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD MAR
PY 2019
VL 34
IS 3
BP 554
EP +
DI 10.1016/j.arth.2018.11.017
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HL1ZF
UT WOS:000458502300029
PM 30545653
OA Bronze
DA 2026-07-24
ER

PT J
AU Kostiuk, V
   Fereydooni, S
   Setia, O
   Loh, SA
   Strosberg, D
   Tonnessen, BH
   Chaar, CIO
   Aboian, E
AF Kostiuk, Valentyna
   Fereydooni, Soraya
   Setia, Ocean
   Loh, Sarah A.
   Strosberg, David
   Tonnessen, Britt H.
   Chaar, Cassius Iyad Ochoa
   Aboian, Edouard
TI Comparative analysis of negative pressure wound therapy (PICO) and
   standard dressing application after arterial vascular reconstructions
SO VASCULAR
LA English
DT Article
DE Surgical wound infection; surgical wound; negative pressure wound
   therapy; PICO dressing; arterial reconstruction
ID GROIN; TRANSVERSE; INFECTION; INCISION
AB Introduction: Surgical site infections following arterial reconstructions with femoral exposures are common and potentially preventable. Negative pressure wound therapy has emerged as a potential solution to minimize groin wound complications. Our study evaluates efficacy of a negative pressure therapy (PICO dressing) in reducing groin wound complications after vascular reconstructions. Methods: A retrospective single center comparative analysis of vascular reconstructions involving common femoral artery dissection was performed between July 2021 and June 2023. Patients were divided into two groups: patients treated with PICO device and patients who received standard dressing (non-PICO). Patient demographics, comorbidities, vascular evaluation, and procedure indications were compared. Previous interventions, incision orientation and procedure types were noted. The wound complication categories were graded according to the Szilagyi classification: grade 1 (superficial infection/minor dehiscence), grade 2 (deep infection/major dehiscence), and grade 3 (artery or prosthetic involvement). Statistical significance level was determined at p < .05 for all analyses. Results: A total of 217 groin dissections in 184 patients were analyzed with 132 and 85 groin dissections in the PICO and non-PICO groups, respectively. The baseline characteristics were similar between the groups in terms of age, sex, BMI, and procedure indications. Prior endovascular procedures and re-operative groin surgeries were more prevalent in the PICO group. The use of antibiotics post-operatively for groin wound complication was greater in the non-PICO group. The incidence of wound complications was higher in the non-PICO group (29.4% vs 10.6%, p < .001). Multivariate logistic regression analysis determined that PICO dressing as well as hybrid and endovascular index procedures were associated with lower risks of groin complications. Conclusion: PICO dressing decreased the incidence of groin wound complications in patients undergoing open vascular reconstructions. This study highlights the value of adjunctive negative pressure therapy in reduction of wound complications after arterial reconstructions in the inguinal region.
C1 [Kostiuk, Valentyna; Fereydooni, Soraya] Yale Univ, Sch Med, New Haven, CT 06520 USA.
   [Setia, Ocean; Loh, Sarah A.; Strosberg, David; Tonnessen, Britt H.; Chaar, Cassius Iyad Ochoa; Aboian, Edouard] Yale Univ, Sch Med, Dept Surg, Div Vasc Surg & Endovasc Therapy, 333 Cedar St,Boardman Bldg, New Haven, CT 06520 USA.
C3 Yale University; Yale University
RP Aboian, E (通讯作者)，Yale Univ, Sch Med, Dept Surg, Div Vasc Surg & Endovasc Therapy, 333 Cedar St,Boardman Bldg, New Haven, CT 06520 USA.
EM edouard.aboian@yale.edu
RI Tonnessen, Britt/KIA-8309-2024
CR Audu CO, 2019, J VASC SURG, V69, P532, DOI 10.1016/j.jvs.2018.05.221
   Ban KA, 2017, J AM COLL SURGEONS, V224, P59, DOI 10.1016/j.jamcollsurg.2016.10.029
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   Parikh PP, 2018, ANN VASC SURG, V47, P143, DOI 10.1016/j.avsg.2017.08.019
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NR 14
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD DEC
PY 2025
VL 33
IS 6
BP 1304
EP 1310
DI 10.1177/17085381241296606
EA OCT 2024
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9ZM7O
UT WOS:001346012600001
PM 39460535
DA 2026-07-24
ER

PT J
AU Guo, CC
   Cheng, T
   Li, JS
AF Guo, Chenchen
   Cheng, Tao
   Li, Junsheng
TI Prophylactic negative pressure wound therapy for closed laparotomy
   incisions after ventral hernia repair: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Prophylactic negative pressure wound therapy; pNPWT; Ventral hernia;
   Incisional hernia; Surgical site infection; SSI
ID SURGICAL SITE INFECTION; RISK; PREVENTION; MANAGEMENT
AB Purpose: To evaluate the efficacy of prophylactic negative pressure wound therapy (pNPWT) in preventing surgical site infection (SSI), hernia recurrence and other wound complications following closed laparotomy incisions following ventral hernia repair (VHR).
   Methods: A comprehensive literature search of PubMed, the Cochrane Central Register of Controlled Trials, Embase and ClinicalTrials.gov databases was performed from inception until June 30, 2021, to identify all online English publications comparing the use of pNPWT with standard dressing for closed laparotomy incision following VHR.
   Results: One RCT and eleven retrospective cohort studies involving 1355 patients satisfied the basic inclusion criteria. The use of pNPWT reduced SSI (OR = 0.39 [95% CI: 0.24-0.62] P < 0.0001) and surgical site occurrence (SSO) (OR = 0.51 [95% CI: 0.27-0.98] P = 0.04). No statistically significant difference was detected in the incidence of hernia recurrence (OR = 0.61 [95% CI: 0.30-1.26] P = 0.18), seroma (OR = 0.70 [95% CI: 0.48-1.03]P = 0.07), hematoma (OR = 0.77 [95% CI: 0.33-1.81]P = 0.55) and wound dehiscence (OR = 0.68 [95% CI: 0.43-1.08]P = 0.10).
   Conclusion: Use of pNPWT for closed laparotomy incisions following ventral hernia repair can significantly reduce the rate of postoperative surgical site infection (especially for superficial SIS) and surgical site occurrences. The number needed to treat (NNT) for preventing one occurrence of SSI is 9 patients. However, further research and more high quality studies are required to assess the effectiveness and assist in clarifying the role of pNPWT for closed laparotomy incisions following ventral hernia repair, preferentially in high-risk populations of developing SSI.
C1 [Guo, Chenchen] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
   [Cheng, Tao; Li, Junsheng] Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Li, JS (通讯作者)，Southeast Univ, Affiliated Zhongda Hosp, Dept Gen Surg, Nanjing 210009, Peoples R China.
EM Lijunshenghd@126.com
RI ; Li, Junsheng/E-4990-2013
OI Guo, Chenchen/0000-0003-3182-8671; 
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   Yu LL, 2018, AM J OBSTET GYNECOL, V218, P200, DOI 10.1016/j.ajog.2017.09.017
NR 35
TC 16
Z9 18
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JAN
PY 2022
VL 97
AR 106216
DI 10.1016/j.ijsu.2021.106216
EA JAN 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YF5CU
UT WOS:000741825200008
PM 34990831
DA 2026-07-24
ER

PT J
AU Prete, FP
   De Luca, GM
   Sgaramella, LI
   Poli, E
   Malerba, S
   Puglisi, GR
   Moschou, M
   Saponara, B
   Marano, L
   Gurrado, A
   Coccolini, F
   Catena, F
   Testini, M
AF Prete, Francesco Paolo
   De Luca, Giuseppe Massimiliano
   Sgaramella, Lucia Ilaria
   Poli, Elisabetta
   Malerba, Silvia
   Puglisi, Giuliana Rachele
   Moschou, Maria
   Saponara, Bruna
   Marano, Luigi
   Gurrado, Angela
   Coccolini, Federico
   Catena, Fausto
   Testini, Mario
TI Late closure of the open abdomen in emergency abdomino-pelvic surgery:
   Advanced indications to negative pressure wound therapy?
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Open abdomen; Pelvic trauma;
   Intra-abdominal infection; Enteroatmospheric fistula
ID PRIMARY FASCIAL CLOSURE; ABDOMINAL SEPSIS; DELAYED CLOSURE; SEPTIC
   PATIENTS; MANAGEMENT; CLASSIFICATION; FISTULAS
AB Background Damage control surgery(DCS) is a well-established approach in emergency laparotomy when physiologic instability necessitates an abbreviated operation. In severe intraabdominal infections(IAI), open abdomen(OA) with Negative Pressure Wound Therapy(NPWT) has shown significant efficacy to help reducing morbidity and mortality. Early definitive abdominal closure is recommended to minimize complications, though not always achievable. Methods From 108 cases of DCS and OA with NPWT performed between February 2015 and February 2024, 72 consecutive patients treated for severe IAI were retrospectively reviewed. We comparatively analyzed clinical and perioperative data of patients treated with OA for <= 7 days(short OA) or for > 7 days(long OA), focusing on late OA closure(> 7 days). Primary outcome was overall 30-day survival, secondary outcome the primary fascial closure rate. Results The main indication for OA was abdominal contamination. Fifty-six patients had short OA, 16 long OA. Overall mortality was 23.6%, with APACHE II score the only independent predictor (OR 1.9, 95% CI 1.25-2.92, p = 0.003). Fifty-two patients survived to achieve early closure and 12 late closure, respectively. Overall PFC rate was 92.2% (59 patients), 75% within late closure (p = 0.001). Compared to short OA, in long OA nine patients (56.3%, p < 0.001) experienced intraabdominal complications including enteroatmospheric fistula (EAF-3, 18.8%) and frozen abdomen (7, 43.8%); in 10 patients (87.5%, p < 0.001) NPWT regimen was modified to isolate and divert effluent or clean a contaminated field. Conclusions Late closure of the OA for IAI may significantly associate with EAF and frozen abdomen. In these challenging scenarios NPWT specific properties may be leveraged to address complex anatomical situations, extensive contamination, or the need for targeted wound-healing responses.
C1 [Prete, Francesco Paolo; De Luca, Giuseppe Massimiliano; Sgaramella, Lucia Ilaria; Poli, Elisabetta; Malerba, Silvia; Puglisi, Giuliana Rachele; Moschou, Maria; Gurrado, Angela; Testini, Mario] Univ Bari, Policlin Bari, Acad Div Gen Surg Bonomo, Dept Precis & Regenerat Med & Jonian Area DiMePRe, 11 Piazza Giulio Cesare, I-70124 Bari, Italy.
   [Saponara, Bruna] Univ Bari, Hosp Pharm Serv, Dept Pharmacol, Bari, Italy.
   [Marano, Luigi] Acad Appl Med & Social Sci AMiSNS, Dept Surg, Elblag, Poland.
   [Coccolini, Federico] Pisa Univ Hosp, Gen Emergency & Trauma Surg, Pisa, Italy.
   [Catena, Fausto] Bufalini Hosp, Gen & Emergency Surg, Cesena, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Pisa; Azienda Ospedaliero Universitaria Pisana
RP Sgaramella, LI (通讯作者)，Univ Bari, Policlin Bari, Acad Div Gen Surg Bonomo, Dept Precis & Regenerat Med & Jonian Area DiMePRe, 11 Piazza Giulio Cesare, I-70124 Bari, Italy.
EM ilaria.sgaram@gmail.com
RI Sgaramella, Lucia'Ilaria/LMQ-3099-2024; Coccolini,
   Federico/AAJ-6507-2020; Prete, Francesco/J-7141-2019; Marano,
   Luigi/K-4944-2013; GURRADO, ANGELA/HZM-4980-2023
OI Poli, Elisabetta/0009-0000-6693-9393
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD DEC 6
PY 2025
VL 21
IS 1
AR 4
DI 10.1186/s13017-025-00660-0
PG 14
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AZ4VB
UT WOS:001660448000001
PM 41351174
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lorenzo, LR
   Salto, EA
   Cañas, EG
   González, ZM
   Espi, MS
   Gaibar, AG
AF Lorenzo, Laura Rodriguez
   Salto, Eduardo Arrea
   Canas, Elena Gonzalez
   Gonzalez, Zoilo Madrazo
   Espi, Marta Santos
   Gaibar, Antonio Gimenez
TI Incisional Negative Pressure Wound Therapy After Revascularisation
   Surgery in Patients with Peripheral Arterial Disease: A Randomised Trial
   (PICO-Vasc Study)
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Groin surgical wound; Incisional negative pressure wound therapy;
   Surgical site infection; Surgical site occurrence
ID SURGICAL SITE INFECTION; PREVENTION; GROIN; COMPLICATIONS; MANAGEMENT;
   MALNUTRITION; METAANALYSIS; GUIDELINE; ISCHEMIA
AB Objective: This study assessed the potential benefits of using incisional negative pressure wound therapy (iNPWT) for patients undergoing revascularisation due to peripheral arterial disease. Methods: A prospective randomised controlled trial was conducted to compare the inguinal application of iNPWT vs. standard surgical dressings. Patients were enrolled from February 2021 to November 2022. A total of 133 groin incisions were randomised (66 intervention group, 67 control group). The randomisation sequence was carried out by permuted blocks and allocation assigned by opening opaque envelopes once the revascularisation procedure had finished. Wound healing and complication rates were assessed at postoperative days 5, 14, and 30. Primary and secondary endpoints were: 30 day post-operative surgical site infection (SSI) and surgical site occurrence (SSO) rates, defined as a surgical wound complication other than a SSI. Post-operative SSI was defined according to the US Centers for Disease Control and Prevention criteria. SSO included: wound dehiscence, seroma or lymphocele, haematoma, and lymphorrhagia. The study was registered at ClinicalTrials.gov database (NCT04840576) and reported according to the CONSORT guidelines. Results: iNPWT did not modify the 30 day inguinal SSI and SSO rates (16.7% vs. 20.9% and 37.9% vs. 44.8%; p = .53, relative risk [RR] 0.999, 95% confidence interval [CI] 0.52 - 1.88 and p = .42, RR 1.29, 95% CI 0.89 - 1.86, respectively). It reduced the early SSO rate (19.7% vs. 35.8%; p = .044, RR 1.45, 95% CI 1.047 - 2.013) and postoperative seroma rate (4.6% vs. 19.4%; p = .014, RR 1.73, 95% CI 1.296 - 2.397). Conclusion: There were no differences in SSI and SSO rates, although statistically significant reductions in early SSO rates and seroma were found in the intervention group.
C1 [Lorenzo, Laura Rodriguez; Salto, Eduardo Arrea; Canas, Elena Gonzalez; Gonzalez, Zoilo Madrazo; Gaibar, Antonio Gimenez] Corp Sanitaria Parc Tauli, Vasc Surg Dept, Barcelona, Spain.
   [Gonzalez, Zoilo Madrazo] Bellvitge Univ Hosp, Gen Surg Dept, Barcelona, Spain.
C3 Autonomous University of Barcelona; Parc Tauli Hospital Universitari;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona
RP Lorenzo, LR (通讯作者)，Hosp Sabadell, Corp Sanitaria Parc Tauli, One Parc Tauli, Barcelona 08208, Spain.
EM lmrodriguez@tauli.cat
RI ; Arrea Salto, Eduardo/JOZ-6047-2023; Madrazo, Zoilo/ADE-9129-2022
OI GIMENEZ-GAIBAR, ANTONIO/0000-0002-1837-4989; GONZALEZ,
   ELENA/0000-0002-7509-7404; Arrea Salto, Eduardo/0000-0002-6804-1146;
   ROIGUEZ LORENZO, LAURA/0000-0003-2977-4627; Santos Espí,
   Marta/0000-0003-1801-2491; 
FX Funding This study was promoted and initiated by the principal
   investigator and did not receive any funding or sponsorship.
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NR 53
TC 8
Z9 9
U1 0
U2 6
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD AUG
PY 2024
VL 68
IS 2
BP 238
EP 244
DI 10.1016/j.ejvs.2024.04.031
EA AUG 2024
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA C5D1J
UT WOS:001289559300001
PM 38677468
OA Bronze
DA 2026-07-24
ER

PT J
AU Ahmad, J
   Hindawi, MD
   Hamdy, AM
   AL-Ihribat, AR
   Salloum, OH
   Marrawani, M
   Jibril, NS
   Elewidi, M
   Elbelkasi, H
   Kalmoush, A
   Kirkpatrick, AW
   Tan, ECTH
AF Ahmad, Jamal
   Hindawi, Mahmoud Diaa
   Hamdy, Ahmed Mohamed
   Al-Ihribat, Alaa R.
   Salloum, Omar Hammam
   Marrawani, Mohammad
   Jibril, Nada S.
   Elewidi, Mariam
   Elbelkasi, Hamdi
   Kalmoush, Abd-Elfattah
   Kirkpatrick, Andrew W.
   Tan, Edward C. T. H.
TI Closed incision negative pressure wound therapy after emergency
   laparotomy: a systematic review and Meta-analysis of randomized
   controlled trials
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Emergency laparotomy; Acute care surgery; Negative pressure wound
   therapy; Surgical site infection; Incisional NPWT; Wound complications
ID PREVENTION
AB PurposeEmergency laparotomy is associated with high rates of postoperative wound complications, contributing substantially to patient morbidity and healthcare burden. Closed incision negative pressure wound therapy (ciNPWT) has been proposed as a prophylactic strategy to reduce wound-related complications; however, its effectiveness in the emergency laparotomy setting remains uncertain. We evaluated whether ciNPWT reduces wound complications after emergency laparotomy compared with standard dressings.MethodsThis study is a systematic review and meta-analysis of randomized controlled trials (RCTs). Six databases and trial registries were systematically searched for RCTs from inception to October 10, 2025, with the search subsequently updated using automated database alerts (RSS) up to the time of manuscript submission.ResultsSix randomized controlled trials (1208 patients) were included. Compared with standard dressings, ciNPWT reduced overall wound morbidity (RR 0.49, 95% CI 0.38-0.62; I2 = 0%) and overall SSI (RR 0.40, 95% CI 0.26-0.61; I2 = 0%). ciNPWT also reduced superficial SSI (RR 0.46, 95% CI 0.24-0.85) and wound dehiscence (RR 0.40, 95% CI 0.20-0.80). No significant differences were observed for seroma (RR 0.59, 95% CI 0.34-1.01), length of hospital stay (MD - 0.43 days, 95% CI- 1.14 to 0.29), mortality (RR 1.18, 95% CI 0.64-2.15), or 30-day complications (RR 0.98, 95% CI 0.85-1.15).ConclusionIn adult patients undergoing emergency laparotomy with primary abdominal closure, ciNPWT significantly reduces key incision-related complications, particularly superficial SSI and wound dehiscence. Its clinical benefit appears confined to incision-level outcomes, with no effect on systemic or multifactorial postoperative endpoints. These findings support the selective use of ciNPWT in high-risk emergency laparotomy patients and highlight the need for standardized application protocols and longer-term outcome assessment.
C1 [Ahmad, Jamal; Al-Ihribat, Alaa R.; Salloum, Omar Hammam; Marrawani, Mohammad] Palestine Polytech Univ, Fac Med, Hebron, Palestine.
   [Hindawi, Mahmoud Diaa] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Hindawi, Mahmoud Diaa] Negida Acad, Arlington, MA USA.
   [Hamdy, Ahmed Mohamed] Zagazig Univ, Fac Med, Sharkia, Egypt.
   [Salloum, Omar Hammam] Palestinian Clin Res Ctr, Bethlehem, Palestine.
   [Jibril, Nada S.] Menoufia Univ, Fac Med, Menoufia, Egypt.
   [Elewidi, Mariam] Tanta Univ, Fac Med, Tanta, Egypt.
   [Elbelkasi, Hamdi] Mataryia Teaching Hosp GOTHI, Cairo, Egypt.
   [Kalmoush, Abd-Elfattah] Al Azhar Univ, Gen Surg Dept, Cairo, Egypt.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Crit Care Med, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB, Canada.
   [Tan, Edward C. T. H.] Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands.
C3 Palestine Polytechnic University; Egyptian Knowledge Bank (EKB); Al
   Azhar University; Egyptian Knowledge Bank (EKB); Zagazig University;
   Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; University of Calgary; University Calgary Hospital;
   University of Calgary; University Calgary Hospital; Radboud University
   Nijmegen
RP Tan, ECTH (通讯作者)，Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands.
EM dr.md.hunt@gmail.com; Edward.tan@radboudumc.nl
RI Salloum, Omar/AFW-7490-2022; Al-Ihribat, Alaa/LBI-3214-2024; Tan,
   Edward/L-4681-2015; Kalmoush, Abd-Elfattah/ABP-3296-2022; Hindawi,
   Mahmoud Diaa/QAX-6061-2026
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   Nho RLH, 2012, J VISC SURG, V149, pE3, DOI 10.1016/j.jviscsurg.2012.05.004
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   Philip EF, 2024, WORLD J EMERG SURG, V19, DOI 10.1186/s13017-024-00560-9
   Ramesh Gowthaam, 2025, Cureus, V17, pe91124, DOI 10.7759/cureus.91124
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   Zabaglo M, 2025, STATPEARLS
NR 31
TC 1
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD FEB 17
PY 2026
VL 21
IS 1
AR 16
DI 10.1186/s13017-026-00679-x
PG 14
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA FN6MC
UT WOS:001723049300001
PM 41703609
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wierdak, M
   Pisarska-Adamczyk, M
   Wysocki, M
   Major, P
   Kolodziejska, K
   Nowakowski, M
   Vongsurbchart, T
   Pedziwiatr, M
AF Wierdak, M.
   Pisarska-Adamczyk, M.
   Wysocki, M.
   Major, P.
   Kolodziejska, K.
   Nowakowski, M.
   Vongsurbchart, T.
   Pedziwiatr, M.
TI Prophylactic negative-pressure wound therapy after ileostomy reversal
   for the prevention of wound healing complications in colorectal cancer
   patients: a randomized controlled trial
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Prophylactic negative pressure wound therapy; Ileostomy closure;
   Prevention of wound-related complications; Colorectal cancer operation;
   Randomized controlled trial
ID SURGICAL SITE INFECTION; LOW ANTERIOR RESECTION; RECTAL-CANCER; CLOSURE;
   METAANALYSIS; OUTCOMES
AB Background The aim of this study was to assess the usefulness of protective negative-pressure wound therapy (NPWT) in the reduction of wound healing complications (WHC) and surgical site infections (SSI) after diverting ileostomy closure in patients who underwent surgery for colorectal cancer. Methods In this prospective randomized clinical trial in a tertiary academic surgical center, patients who had colorectal cancer surgery with protective loop ileostomy and were scheduled to undergo ileostomy closure with primary wound closure from January 2016 to December 2018 were randomized to be treated with or without NPWT. The primary endpoint was the incidence of WHC. Secondary endpoints were incidence of SSI, length of postoperative hospital stay (LOS), and length of complete wound healing (CWH) time. Results We enrolled 35 patients NPWT (24 males [68.6%]; mean age 61.6 +/- 11.3 years), with NPWT and 36 patients (20 males [55.6%]; mean age 62.4 +/- 11.3 years) with only primary wound closure (control group). WHC was observed in 11 patients (30.6%) in the control group and 3 (8.57%) in the NPWT group (p = 0.020). Patients in the NPWT group had a significantly lower incidence of SSI (2 [5.71%] vs. 8 [22.2%] in the control group; p = 0.046) as well as significantly shorter median CWH (7 [7-7] days vs. 7 [7-15.5] days, p = 0.030). There was no difference in median LOS between groups (3 [2.5-5] days in the control group vs. 4 [2-4] days in the NPWT group; p = 0.072). Conclusions Prophylactic postoperative NPWT after diverting ileostomy closure in colorectal cancer patients reduces the incidence of WRC and SSI.
C1 [Wierdak, M.; Pisarska-Adamczyk, M.; Wysocki, M.; Major, P.; Kolodziejska, K.; Nowakowski, M.; Vongsurbchart, T.; Pedziwiatr, M.] Jagiellonian Univ Med Coll, Dept Gen Surg 2, Jakubowskiego 2 Str, PL-30688 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wysocki, M (通讯作者)，Jagiellonian Univ Med Coll, Dept Gen Surg 2, Jakubowskiego 2 Str, PL-30688 Krakow, Poland.
EM mateusz.wierdak@uj.edu.pl; magdalena.pisarska@doctoral.uj.edu.pl;
   m.wysocki@doctoral.uj.edu.pl; piotr.major@uj.edu.pl;
   kat.truszkiewicz@gmail.com; m.nowakowski@uj.edu.pl;
   tanawatv19@gmail.com; michal.pedziwiatr@uj.edu.pl
RI Nowakowski, Michal/HTT-3696-2023; Pedziwiatr, Michal/B-1594-2016;
   Pisarska-Adamczyk, Magdalena/ABD-7785-2020
FU Jagiellonian University Medical College; NPWT equipment producers
FX This research was financed only by the Jagiellonian University Medical
   College own funds, without any financial or material support from the
   NPWT equipment producers.
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NR 21
TC 39
Z9 46
U1 0
U2 5
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD FEB
PY 2021
VL 25
IS 2
BP 185
EP 193
DI 10.1007/s10151-020-02372-w
EA NOV 2020
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA QH6IF
UT WOS:000587268600001
PM 33161523
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Marongiu, F
   Buggi, F
   Mingozzi, M
   Curcio, A
   Folli, S
AF Marongiu, Francesco
   Buggi, Federico
   Mingozzi, Matteo
   Curcio, Annalisa
   Folli, Secondo
TI A rare case of primary necrotising fasciitis of the breast: combined use
   of hyperbaric oxygen and negative pressure wound therapy to conserve the
   breast. Review of literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Breast conservation; Hyperbaric oxygen; Negative pressure wound therapy;
   Primary necrotising fasciitis of the breast
ID INFECTION
AB Necrotising fasciitis is a rare but potentially fatal disease. It is even more unusual as a primary disease of the breast. Surgical treatment is required in order to gain control over the spreading infection and mastectomy is reported to be the most common procedure. We report the first case of an otherwise healthy woman exhibiting a primary necrotising fasciitis of the breast, which was treated combining conservative surgery with hyperbaric oxygen (HO) and negative pressure wound therapy (NPWT). A 39-year-old woman presented to the emergency room with fever and swelling of her right breast. The physical examination showed oedema and erythema of the breast, with bluish blisters on the lower quadrant. Ultrasound and CT scans showed diffuse oedema of the entire right breast, with subdermal gas bubbles extending to the fascial planes. Few hours later the necrotic area extended regardless an IV antibiotic therapy; a selective debridement of all breast necrotic tissue was performed and repeated 7 days later. The HO was started immediately after the first surgery and repeated daily (2.8Bar, 120 min) for 18 days and then a NPWT (120-135 mmHg) was applied. Forty-five days after the last debridement, the breast wound was covered with a full-thickness skin graft. Several months later, an excellent cosmetic result was observed. This is the first case of primary necrotising fasciitis of the breast treated associating HO and NPWT to surgical debridement only; this combination resulted in a complete recovery with the additional benefit of breast conservation. Such result is discussed in light of the available literature on the treatment of primary necrotising fasciitis of the breast.
C1 [Marongiu, Francesco; Buggi, Federico; Mingozzi, Matteo; Curcio, Annalisa; Folli, Secondo] Morgagni Pierantoni Hosp, Breast Unit, Via Carlo Forlanini 34, I-07100 Sassari, Italy.
RP Marongiu, F (通讯作者)，Morgagni Pierantoni Hosp, Breast Unit, Via Carlo Forlanini 34, I-07100 Sassari, Italy.
EM marongiufra@gmail.com
RI Folli, Secondo/AAB-2227-2020
OI Folli, Secondo/0000-0003-3465-3010
CR Angarita FA, 2014, BREAST CANCER-TOKYO, V21, P108, DOI 10.1007/s12282-010-0219-4
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NR 18
TC 15
Z9 17
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2017
VL 14
IS 2
BP 349
EP 354
DI 10.1111/iwj.12607
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EQ4SH
UT WOS:000398068200009
PM 27146346
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kim, JH
   Lee, DH
AF Kim, Jun-Ho
   Lee, Dae-Hee
TI Negative pressure wound therapy vs. conventional management in open
   tibia fractures: Systematic review and meta-analysis
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Negative pressure wound therapy; Conventional wound management; Open
   tibia fractures; Systematic review; Meta-analysis
ID LOWER-LIMB; VACUUM; INFECTION; CLOSURE; FLAP; COVERAGE; OUTCOMES; RISK
AB Background: Severe open tibia fractures are disastrous injuries associated with a high incidence of complications. Negative pressure wound therapy (NPWT) is a novel treatment for open tibia fractures; however, its efficacy remains unclear. This is a systematic review and meta-analysis performed to evaluate the effect of NPWT on decreasing the infection rate, amputation rate, nonunion rate, and flap-related complications in open tibia fractures.
   Methods: The MEDLINE, EMBASE, and Cochrane Library databases were systematically searched. Complications were evaluated in terms of the rates of infection, amputation, nonunion, and flap-related complications.
   Results: Twelve studies were included. In the meta-analysis, NPWT showed significantly lower soft-tissue infection rate (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.34-0.68, P < 0.0001), nonunion rate (OR 0.61, 95% CI 0.39-0.95, P = 0.03), flap necrosis rate (OR 0.37, 95% CI 0.21-0.63, P = 0.0003), and flap revision rate (OR 0.44, 95% CI 0.22-0.89, P = 0.02) than conventional wound management. However, no significant difference was found in osteomyelitis rate (OR 0.54, 95% CI 0.09-3.28, P = 0.50) and amputation rate (OR 0.89, 95% CI 0.36-2.22, P = 0.80) between the 2 groups.
   Conclusion: Lower rates of soft-tissue infection, nonunion, flap necrosis, and flap revision were observed in the NPWT group than in the conventional dressing group. However, additional high-quality studies are warranted to verify the efficacy of NPWT in the treatment of severe open tibia fractures. We could not make a definitive conclusion about the comparative efficacy of the 2 methods in terms of complications because of insufficient data. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Kim, Jun-Ho; Lee, Dae-Hee] Sungkyunkwan Univ, Samsung Med Ctr, Dept Orthopaed Surg, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Samsung Med Ctr, Dept Orthopaed Surg, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM junojuno49@gmail.com; eoak22@empal.com
RI Lee, Dae-Hee/I-9390-2017
OI Lee, Dae-Hee/0000-0003-3147-8763
FU SMC-Ottogi Research Fund [SMX1162171]
FX This study was supported by SMC-Ottogi Research Fund (SMX1162171).
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NR 30
TC 26
Z9 36
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD OCT
PY 2019
VL 50
IS 10
BP 1764
EP 1772
DI 10.1016/j.injury.2019.04.018
PG 9
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA JJ2FC
UT WOS:000493975800026
PM 31047682
DA 2026-07-24
ER

PT J
AU Blalock, L
AF Blalock, Lindsey
TI Use of Negative Pressure Wound Therapy With Instillation and a Novel
   Reticulated Open-cell Foam Dressing With Through Holes at a Level 2
   Trauma Center
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation; NPWTi-d; wound care;
   chronic wounds; reticulated open cell foam dressing with through holes;
   ROCF-CC
AB Introduction. Current wound treatment options for complex wounds include advanced wound therapies. One such treatment, negative pressure wound therapy (NPWT), has evolved to include automated instillation of topical wound solutions with a user-specified dwell time (NPWTi-d). A novel reticulated open-cell foam dressing with through holes (ROCF-CC) was developed to assist wound cleansing by removing thick wound exudate and infectious material. Objective. The author's experience using NPWTi-d with ROCF-CC on complex wounds is presented. Materials and Methods. Patients (N = 19) received antibiotics, pain medication (oral or intravenous), and debridement when applicable. The ROCF-CC contact layer with through holes was cut to fit the wound dimensions and placed in the wound bed. The cover layer (without holes) was placed over the contact layer to fill the remainder of the wound bed, including undermined areas. The foam layers were covered with a semi-occlusive drape, and NPWTi-d was initiated by instilling saline or a hypochlorous solution with a 1-minute to 10-minute dwell time followed by 2 to 3.5 hours of negative pressure (-125 mm Hg or -150 mm Hg). Dressing changes were performed every 2 to 3 days. Results. Mean patient age was 57.1 +/- 18.1 years. Common comorbidities included diabetes, obesity, and tobacco use. After an average of 9.0 +/- 6.9 days of therapy, all wounds displayed less malodor, less devitalized tissue, and improved granulation tissue formation. Conclusions. In all 19 cases, adjunctive use of NPWTi-d with ROCF-CC contributed to hospital discharge, wound closure, and successful limb salvage in this patient population.
C1 [Blalock, Lindsey] Integumetrix, Nashville, TN USA.
RP Blalock, L (通讯作者)，Integumetrix, TriStar Skyline Med Ctr, 3441 Dickerson Pike, Nashville, TN 37207 USA.
EM lindsey@integumetrix.com
CR Applewhite Andrew, 2018, Wounds, V30, pS19
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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   Gabriel A, EPLASTY
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NR 13
TC 12
Z9 12
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2019
VL 31
IS 2
BP 55
EP 58
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4ZZ
UT WOS:000484282300008
PM 30485170
DA 2026-07-24
ER

PT J
AU Tuffaha, HW
   Gillespie, BM
   Chaboyer, W
   Gordon, LG
   Scuffham, PA
AF Tuffaha, Haitham W.
   Gillespie, Brigid M.
   Chaboyer, Wendy
   Gordon, Louisa G.
   Scuffham, Paul A.
TI Cost-utility analysis of negative pressure wound therapy in high-risk
   cesarean section wounds
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Cost-effectiveness; Negative pressure wound therapy; Cesarean section;
   Value of information
ID SURGICAL-SITE INFECTIONS; INFORMATION ANALYSIS; HEALTH-CARE;
   DECISION-MAKING; RESEARCH DESIGN; EXPECTED VALUE; TRIAL DESIGN; OBESITY;
   IMPACT; WOMEN
AB Background: Obese women undergoing cesarean section are at increased risk of postoperative infection. There is growing interest in negative pressure wound therapy (NPWT) to prevent closed surgical incision complications including surgical site infection; however, the evidence on the effectiveness and cost-effectiveness of this technology is limited. The objective of this study was to evaluate the cost-effectiveness of NPWT compared with that of standard dressing in preventing surgical site infection in obese women undergoing elective cesarean section based on current evidence and to estimate the value and optimal design of additional research to study this technology.
   Methods: The analysis was from the perspective of Queensland Health, Australia, using a decision model. Parameters were obtained from the published literature, a pilot clinical trial, and expert opinion. Monte Carlo simulation was performed to calculate the net monetary benefit, characterize decision uncertainty, and estimate the value of additional research. Comparing the expected monetary benefits and costs of alternative trial sample sizes informed the optimal future study design.
   Results: The incremental net monetary benefit of NPWTwas Australian dollars 70, indicating that NPWT is cost-effective compared with that of standard dressing. The probability of NPWT being cost-effective was 65%. The estimated value of additional research to resolve decision uncertainty would be Australian dollars 2.7 million. The optimal sample size of a future trial investigating the relative effectiveness of NPWT would be 200 patients per arm.
   Conclusions: Based on the current evidence, NPWT is cost-effective; however, there is high uncertainty surrounding the decision to adopt this technology. Additional research is worthwhile before implementation. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tuffaha, Haitham W.; Gillespie, Brigid M.; Chaboyer, Wendy; Gordon, Louisa G.; Scuffham, Paul A.] Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld, Australia.
   [Tuffaha, Haitham W.; Gordon, Louisa G.; Scuffham, Paul A.] Griffith Univ, Sch Med, Ctr Appl Hlth Econ, Meadowbrook, Qld 4131, Australia.
   [Tuffaha, Haitham W.; Gillespie, Brigid M.; Chaboyer, Wendy] Griffith Univ, Res Ctr Hlth Practice Innovat, CNHMRC Ctr Res Excellence Nursing Intervent Hospi, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Griffith
   University; Griffith University
RP Tuffaha, HW (通讯作者)，Griffith Univ, Griffith Hlth Inst, Sch Med, Ctr Appl Hlth Econ, Meadowbrook, Qld 4131, Australia.
EM haitham.tuffaha@griffith.edu.au
RI Chaboyer, Wendy/F-9588-2018; Gillespie, Brigid/E-7799-2012; Scuffham,
   Paul/B-3066-2014; Tuffaha, Haitham/P-2676-2016; Collins,
   Louisa/P-1427-2016
OI Chaboyer, Wendy/0000-0001-9528-7814; Gillespie,
   Brigid/0000-0003-3186-5691; Scuffham, Paul/0000-0001-5931-642X; Tuffaha,
   Haitham/0000-0003-2993-3480; Collins, Louisa/0000-0002-3159-4249
FU National Health and Medical Research Council PhD scholarship through the
   Centre for Research Excellence in Nursing Interventions for Hospitalised
   Patients
FX H.W.T. is supported by a National Health and Medical Research Council
   PhD scholarship through the Centre for Research Excellence in Nursing
   Interventions for Hospitalised Patients.
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NR 60
TC 43
Z9 45
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAY 15
PY 2015
VL 195
IS 2
BP 612
EP 622
DI 10.1016/j.jss.2015.02.008
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA CG9QH
UT WOS:000353651600028
PM 25796106
DA 2026-07-24
ER

PT J
AU Kitano, D
   Sakurai, A
   Kuwazuru, K
   Kitagawa, H
   Taniguchi, T
   Takahara, S
AF Kitano, Daiki
   Sakurai, Atsushi
   Kuwazuru, Kenji
   Kitagawa, Hiroshi
   Taniguchi, Tomoya
   Takahara, Shunsuke
TI Intra-soft tissue and intramedullary antibiotic perfusion in combination
   with negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE continuous local antibiotic perfusion; gentamicin; intramedullary
   antibiotic perfusion; intra-soft tissue antibiotic perfusion; negative
   pressure wound therapy; wound; wound care; wound dressing; wound healing
ID ANTIMICROBIAL SUSCEPTIBILITY; GENTAMICIN; INFECTION
AB Objective: Intra-soft tissue and intramedullary antibiotic perfusion (iSAP and iMAP), which combine continuous administration of antibiotic solution to the wound and negative pressure wound therapy (NPWT), have been reported to be a useful management approach for hard-to-heal ulcers in the field of orthopaedic surgery. We report the efficacy of this treatment and discuss the key points.
   Method: The recipients of this treatment had contaminated fresh severe trauma with a high risk of infection, or hard-to-heal ulcers which were expected to be difficult to manage with conventional NPWT alone. Continuous administration of 1200 mu g/ml of gentamicin (GM) solution to the wound was performed along with NPWT. The GM solution was administered subcutaneously using a small catheter for iSAP, while intramedullary administration used a bone marrow needle for iMAP.
   Results: iSAP was employed in all 10 patients who took part, and iMAP in three of these patients. The average treatment time was 13.6 days with iSAP and 9.3 days with iMAP. The mean serum GM level during the therapy was 1.02 mu g/ml. Moderate GM-induced acute kidney injury was suspected in one case, but resolved spontaneously after GM administration was stopped. Favourable wound bed preparation was achieved in all cases without recurrence of infection.
   Conclusion: Combination with continuous suction by NPWT is able to keep the local concentration of antibiotic above the minimum inhibitory concentration of biofilm-coated bacteria within the wound. We have referred to this treatment as continuous local antibiotic perfusion. Further investigation of local pharmacodynamics in the wound and side-effects of this treatment are warranted. Declaration of interest: The authors have no conflicts of interest.
C1 [Kitano, Daiki; Sakurai, Atsushi; Kitagawa, Hiroshi; Taniguchi, Tomoya] Hyogo Prefectural Kakogawa Med Ctr, Dept Plast Surg, Kakogawa, Hyogo, Japan.
   [Kitano, Daiki] Kobe Univ, Dept Plast Surg, Grad Sch Med, Kobe, Hyogo, Japan.
   [Kuwazuru, Kenji] Mitsubishi Kobe Hosp, Dept Plast Surg, Kobe, Hyogo, Japan.
   [Takahara, Shunsuke] Hyogo Prefectural Kakogawa Med Ctr, Dept Orthoped Surg, Kakogawa, Hyogo, Japan.
C3 Kobe University
RP Kitano, D (通讯作者)，Hyogo Prefectural Kakogawa Med Ctr, Dept Plast Surg, Kakogawa, Hyogo, Japan.; Kitano, D (通讯作者)，Kobe Univ, Dept Plast Surg, Grad Sch Med, Kobe, Hyogo, Japan.
EM d.kitano.poo@gmail.com
RI Sakurai, Atsushi/W-5167-2019; Kitagawa, Hiroshi/CAJ-3523-2022
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NR 30
TC 4
Z9 6
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2023
VL 32
SU 11
BP S14
EP S23
DI 10.12968/jowc.2023.32.Sup11.S14
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA W5XR7
UT WOS:001092359600003
PM 37907367
DA 2026-07-24
ER

PT J
AU Wang, LC
   Wang, CR
   Chen, HM
   Chen, Y
   Li, J
   Xiao, L
   Zhu, D
   Yang, CZ
AF Wang, Liangchen
   Wang, Chenrui
   Chen, Hongmei
   Chen, Ying
   Li, Juan
   Xiao, Li
   Zhu, Di
   Yang, Caizhe
TI The Combined Use of a Non-Invasive Skin-Stretching Device and the
   Negative-Pressure Wound Therapy Technique in the Treatment of
   Postoperative Diabetic Foot
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetic foot; negative-pressure wound therapy; wound healing;
   skin-stretching device
ID ULCERS; CLOSURE; SYSTEM; SECURE
AB Objective: The present study explored the effectiveness of using a non-invasive skin-stretching device (NSSD) combined with negative-pressure wound therapy (NPWT) for the postoperative wound repair of diabetic foot (DF) gangrene.
   Methods: The treatment group in this study involved 42 patients with Wagner grade 3-4 DF and undergone concomitant toe amputation or debridement, who were given NPWT combined with the use of a NSSD. The control group comprised 42 patients with similar trauma areas (+/- 20%) that were matched at a ratio of 1:1. Following surgery, these patients received NPWT combined with the use of conventional dressings. A comparison was made of the postoperative wound healing rates and wound healing times of the two groups, with Kaplan-Meier survival analysis being used to compare the healing rate over time.
   Results: The three-month wound healing rate was higher in the treatment group than in the control group (38 of 42 [90.5%] vs 25 of 42 [59.5%], p = 0.002), and the wound healing time was shorter in the treatment group (44 days [95% CI 40.0-48.0]) than that in the control group (76 days [95% CI 63.0-89.0], p = 0.000). Taking the end of the final NPWT as the starting point, the comparison of wound healing time revealed that this period was shorter in the treatment group than that in the control group and the difference was statistically significant (11 days [95% CI 9.0-13.0] vs 42 days [95% CI 23.0-ND], p = 0.000).
   Conclusion: The use of the NPWT technique combined with a NSSD can shorten the wound healing time and improve the wound healing rate of DF gangrene patients during the postoperative wound repair period.
C1 [Wang, Liangchen; Wang, Chenrui; Chen, Hongmei; Chen, Ying; Li, Juan; Xiao, Li; Zhu, Di; Yang, Caizhe] PLA, Air Force Med Ctr, Dept Endocrinol, Beijing 100142, Peoples R China.
RP Yang, CZ (通讯作者)，PLA, Air Force Med Ctr, Dept Endocrinol, Beijing 100142, Peoples R China.
EM caizheyang06@outlook.com
OI Zhu, Di/0000-0001-8046-0709
FU Beijing Municipal Science and Technology Project: 2018 Clinical
   characteristics and Application Research of Capital [Z181100001718025];
   PLA Youth Training Project for Medical Science [15QNP040]
FX Beijing Municipal Science and Technology Project: 2018 Clinical
   characteristics and Application Research of Capital. (Z181100001718025)
   .PLA Youth Training Project for Medical Science (15QNP040) .
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NR 27
TC 4
Z9 4
U1 0
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 3523
EP 3532
DI 10.2147/DMSO.S322757
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TY0KX
UT WOS:000683474300005
PM 34385827
OA Green Accepted, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Willms, AG
   Schwab, R
   von Websky, MW
   Berrevoet, F
   Tartaglia, D
   Sörelius, K
   Fortelny, RH
   Björck, M
   Monchal, T
   Brennfleck, F
   Bulian, D
   Beltzer, C
   Germer, CT
   Lock, JF
AF Willms, A. G.
   Schwab, R.
   von Websky, M. W.
   Berrevoet, F.
   Tartaglia, D.
   Sorelius, K.
   Fortelny, R. H.
   Bjorck, M.
   Monchal, T.
   Brennfleck, F.
   Bulian, D.
   Beltzer, C.
   Germer, C. T.
   Lock, J. F.
CA Eurahs Open Abdomen Grp
TI Factors influencing the fascial closure rate after open abdomen
   treatment: Results from the European Hernia Society (EuraHS) Registry
   Surgical technique matters
SO HERNIA
LA English
DT Article
DE Open abdomen; Peritonitis; Fascial closure; Hernia; Abdominal
   compartment syndrome; Abdominal trauma; Burst abdomen; NPWT; VAC
ID ASSISTED WOUND CLOSURE; TEMPORARY ABDOMINAL CLOSURE; SEPTIC PATIENTS;
   CONSENSUS DEFINITIONS; DELAYED CLOSURE; DAMAGE CONTROL; VACUUM; MESH;
   THERAPY; TRACTION
AB Purpose Definitive fascial closure is an essential treatment objective after open abdomen treatment and mitigates morbidity and mortality. There is a paucity of evidence on factors that promote or prevent definitive fascial closure. Methods A multi-center multivariable analysis of data from the Open Abdomen Route of the European Hernia Society included all cases between 1 May 2015 and 31 December 2019. Different treatment elements, i.e. the use of a visceral protective layer, negative-pressure wound therapy and dynamic closure techniques, as well as patient characteristics were included in the multivariable analysis. The study was registered in the International Clinical Trials Registry Platform via the German Registry for Clinical Trials (DRK00021719). Results Data were included from 630 patients from eleven surgical departments in six European countries. Indications for OAT were peritonitis (46%), abdominal compartment syndrome (20.5%), burst abdomen (11.3%), abdominal trauma (9%), and other conditions (13.2%). The overall definitive fascial closure rate was 57.5% in the intention-to-treat analysis and 71% in the per-protocol analysis. The multivariable analysis showed a positive correlation of negative-pressure wound therapy (odds ratio: 2.496, p < 0.001) and dynamic closure techniques (odds ratio: 2.687, p < 0.001) with fascial closure and a negative correlation of intra-abdominal contamination (odds ratio: 0.630, p = 0.029) and the number of surgical procedures before OAT (odds ratio: 0.740, p = 0.005) with DFC. Conclusion The clinical course and prognosis of open abdomen treatment can significantly be improved by the use of treatment elements such as negative-pressure wound therapy and dynamic closure techniques, which are associated with definitive fascial closure.
C1 [Willms, A. G.; Schwab, R.] German Armed Forces Cent Hosp Koblenz, Dept Gen Visceral & Thorac Surg, Rubenacher Str 170, D-56072 Koblenz, Germany.
   [von Websky, M. W.] Univ Hosp Bonn, Dept Gen Visceral Thorac & Vasc Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
   [Berrevoet, F.] Ghent Univ Hosp, Dept Gen & HPB Surg & Liver Transplantat, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Tartaglia, D.] Cisanello Univ Hosp, Emergency Surg Unit, Via Paradisa 1, I-56124 Pisa, Italy.
   [Bjorck, M.] Uppsala Univ, Dept Surg Sci, Sect Vasc Surg, SE-75185 Uppsala, Sweden.
   [Sorelius, K.] Univ Copenhagen, Rigshosp, Dept Vasc Surg, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
   [Sorelius, K.] Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
   [Fortelny, R. H.] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, A-1160 Vienna, Austria.
   [Fortelny, R. H.] Sigmund Freud Univ Vienna, Med Fac, A-1020 Vienna, Austria.
   [Monchal, T.] St Anne Mil Hosp, Dept Gen Surg, 2 Blvd St Anne, F-83000 Toulon, France.
   [Brennfleck, F.] Regensburg Univ Hosp, Dept Surg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
   [Bulian, D.] Witten Herdecke Univ, Cologne Merheim Med Ctr, Dept Abdominal Tumor Transplant & Vasc Surg, Ostmerheimer Str 200, D-51109 Cologne, Germany.
   [Beltzer, C.] German Armed Forces Hosp Ulm, Dept Gen Visceral & Thorac Surg, Ulm, Germany.
   [Germer, C. T.; Lock, J. F.] Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
C3 University of Bonn; Ghent University; Ghent University Hospital; Uppsala
   University; University of Copenhagen; Rigshospitalet; University of
   Copenhagen; Wilhelminenspital; University of Regensburg; Ulm University;
   Military Hospital Ulm; University of Wurzburg
RP Lock, JF (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
EM Lock_J@ukw.de
RI Brennfleck, Frank/GOV-6490-2022; Bulian, Dirk Rolf/GQY-7923-2022; Lock,
   Johan/AAA-8114-2020; Tartaglia, Dario/AAJ-1735-2020; von Websky,
   Martin/AFC-6767-2022; /AFN-0812-2022; Fortelny, René/AAD-5922-2021;
   Berrevoet, Frederik/A-6117-2008
OI Brennfleck, Frank/0000-0001-8055-9282; Bulian, Dirk
   Rolf/0000-0002-1311-7326; Lock, Johan/0000-0002-9007-3937; Beltzer,
   Christian/0000-0002-1163-6982
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. No funding
   was received for this work.
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NR 50
TC 17
Z9 23
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2022
VL 26
IS 1
BP 61
EP 73
DI 10.1007/s10029-020-02336-x
EA NOV 2020
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZH9CJ
UT WOS:000591096300001
PM 33219419
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Simon, C
   Fürstenberg, CH
   Eichler, M
   Rohde, S
   Bulut, C
   Wiedenhöfer, B
AF Simon, Christian
   Fuerstenberg, Carl H.
   Eichler, Markus
   Rohde, Stefan
   Bulut, Cem
   Wiedenhoefer, Bernd
TI Management of Pharyngeal Fistulas After Anterior Cervical Spine Surgery
   A Treatment Algorithm for Severe Complications
SO CLINICAL SPINE SURGERY
LA English
DT Article
DE pharyngocutaneous fistulas; anterior cervical spine surgery; treatment
   algorithm; vascularized flap; negative pressure wound therapy
ID CLASSIFICATION-SYSTEM; INJURY; ESOPHAGEAL; RATES; SCI
AB Study Design: This study is a retrospective database query to identify all anterior spinal approaches.
   Objectives: The objectives were to assess all patients with pharyngocutaneous fistulas (PCFs) after anterior cervical spine surgery.
   Summary of Background Data: Patients with the diagnosis of PCFs were treated at the University of Heidelberg Spine Medical Center, Spinal Cord Injury Unit and Department of Otolaryngology (Germany), between 2005 and 2011.
   Methods: We conducted a retrospective study on 5 patients with PCF after anterior cervical spine surgery between 2005 and 2011 and analyzed their therapy management and outcome on the basis of the radiologic data and patient charts.
   Results: Upon presentation, 4 patients were paraplegic. Two patients had PCF arising from 1 piriform sinus, 2 patients had PCF arising from the posterior pharyngeal wall and piriform sinus combined, and 1 patient had PCF arising only from the posterior pharyngeal wall. Two patients previously underwent unsuccessful surgical repair elsewhere and 1 patient underwent a prior radiation therapy. In 3 patients, speech and swallowing could be completely restored. Two patients died, both of whom were paraplegic. The patients were needed to undergo an average of 2 or 3 procedures for complete functional recovery of primary closure with various vascularized regional flaps and refining laser procedures supplemented with the negative pressure wound therapy wherever needed.
   Conclusions: On the basis of our experience, we are able to provide a treatment algorithm that indicates that chronic, as opposed to acute, fistulas require a primary surgical closure combined with a vascularized flap that should be accompanied by the immediate application of a negative pressure wound therapy. We also conclude that particularly in paraplegic patients suffering from this complication the risk for a fatal outcome is substantial.
C1 [Simon, Christian] Univ Lausanne, CHU Vaudois, Serv Otorhinolaryngol ORL, Lausanne, Switzerland.
   [Fuerstenberg, Carl H.; Eichler, Markus; Wiedenhoefer, Bernd] Heidelberg Univ, Dept Orthoped Trauma Surg & Spinal Cord, Schlierbacher Landstr 200a, D-69118 Heidelberg, Germany.
   [Rohde, Stefan] Heidelberg Univ, Dept Neuroradiol, Heidelberg, Germany.
   [Bulut, Cem] Heidelberg Univ, Dept Otolaryngol Head & Neck Surg, Heidelberg, Germany.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg
RP Wiedenhöfer, B (通讯作者)，Heidelberg Univ, Dept Orthoped Trauma Surg & Spinal Cord, Schlierbacher Landstr 200a, D-69118 Heidelberg, Germany.
EM bernd.wiedenhoefer@med.uni-heidelberg.de
RI ; /AAQ-3751-2021
OI Simon, Christian/0000-0002-4156-9143; 
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NR 15
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2380-0186
J9 CLIN SPINE SURG
JI Clin. Spine Surg.
PD FEB
PY 2017
VL 30
IS 1
BP E25
EP E30
DI 10.1097/BSD.0b013e3182999504
PG 6
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA EJ6TJ
UT WOS:000393351400005
PM 28107239
DA 2026-07-24
ER

PT J
AU Meng, FZ
   Ye, JW
   Wu, XM
   Li, JC
   Bian, B
   Li, WS
   Pan, XH
AF Meng, Fengzhen
   Ye, Jianwen
   Wu, Xiaomin
   Li, Jianchi
   Bian, Bin
   Li, Wensong
   Pan, Xiaohua
TI Negative Pressure Wound Therapy Using a New Pressure Monitoring Device
   for Wound Treatment: Results of an Animal Model
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE dressing; negative pressure wound therapy; pressure monitoring;
   real-time monitoring; sensing chip; wound healing
ID SURGICAL-SITE INFECTION; DELIVERY; CLOSURE
AB Background. Negative pressure wound therapy (NPWT) is a widely used therapeutic approach for skin and soft tissue defects, and selecting an appropriate negative pressure value is critically important. Objective. To develop a wound pressure monitoring dressing (WPMD) integrating a novel pressure sensing chip with a previously developed polyvinyl acetate foam dressing. Materials and Methods. Sprague-Dawley male rats were randomly divided into 3 groups to receive-125 mm Hg pressure with the WPMD, -75 mm Hg pressure with the WPMD, or wound dressing without negative pressure (control). Data on pressure changes and wound conditions were collected over 7 consecutive days. Monitoring included pressure changes, gross wound morphology observations, and histopathological analyses. Results. Monitoring data revealed pressure variations during wound healing ranging from-128 mm Hg to-63 mm Hg in the-125 mm Hg preset group, and from-72mm Hg to-37 mm Hg in the-75 mm Hg preset group. The WPMD groups exhibited higher wound closure rates than the control group. Ki67, vascular endothelial growth factor receptor 2, transforming growth factor beta 1, and CD31 expression levels were elevated in the WPMD groups compared with the control group. Conclusion. The WPMD accurately and sensitively detected real-time pressure changes on wound surfaces under different preset negative pressure values (-125 mm Hg and-75 mm Hg). Furthermore, NPWT significantly accelerated wound healing in the rat model, and the healing rates were better in the-75 mm Hg group than in the-125 mm Hg group at day 5 and day 7. These results underscore the potential application of the WPMD in investigating the relationship between negative pressure values and wound healing rates across various wound types during treatment.
C1 [Meng, Fengzhen; Ye, Jianwen; Wu, Xiaomin; Bian, Bin; Li, Wensong; Pan, Xiaohua] Shenzhen Univ, Peoples Hosp Baoan Shenzhen, Affiliated Hosp 2, Dept Orthopaed & Traumatol, Shenzhen, Peoples R China.
   [Li, Jianchi] Jinan Univ, Affiliated Hosp 1, Key Lab Regenerat Med, Inst New Technol Plast Surg,Dept Plast Surg,Minist, Guangzhou, Peoples R China.
C3 Shenzhen University; Jinan University
RP Pan, XH (通讯作者)，Peoples Hosp Baoan Shenzhen, Dept Orthopaed & Traumatol, Baocheng Longjing 2nd Rd 118, Shenzhen 518101, Peoples R China.
EM szpxh4141@foxmail.com
FU Shenzhen Science and Technology Innovation Council of China
   [JCYJ20220530142618040]; Research Project of Bao'an District Medical
   Association in Shenzhen [BAYXH2023004]; Sanming Project of Medicine in
   Shenzhen [SZSM202106019]
FX Financial grant support was received from the Shenzhen Science and
   Technology Innovation Council of China (JCYJ20220530142618040) ,
   Research Project of Bao'an District Medical Association in Shenzhen
   (BAYXH2023004) , and Sanming Project of Medicine in Shenzhen
   (SZSM202106019) to support study materials and editorial assistance.
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NR 24
TC 0
Z9 1
U1 1
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2025
VL 37
IS 4
BP 145
EP 151
DI 10.25270/wnds/24109
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3KV6M
UT WOS:001502754300002
PM 40368389
DA 2026-07-24
ER

PT J
AU Ahn, J
   Park, HY
   Shetty, AA
   Hwang, W
AF Ahn, Jiyong
   Park, Ho Youn
   Shetty, Asode Ananthram
   Hwang, Wonha
TI Use of injectable acellular dermal matrix combined with negative
   pressure wound therapy in open diabetic foot amputation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acellular dermal matrix; amputation; diabetes; diabetic foot ulcer;
   full-thickness skin graft; negative pressure wound therapy; skin graft;
   ulcer; wound; wound care; wound healing
ID ULCERS; RECONSTRUCTION; MANAGEMENT; CLOSURE; RISK
AB Objective: Skin grafts after negative pressure wound therapy (NPWT) and acellular dermal matrix (ADM) usage have both been useful for treating diabetic foot amputation. We hypothesised that injectable ADM combined with NPWT would be more useful than NPWT only for healing after amputation in patients with diabetic foot ulcers (DFUs). The aim of this study was to investigate the clinical outcomes of injectable ADM combined with NPWT in patients with DFU who have undergone amputation.
   Method: This retrospective study reviewed patients with infected DFUs who were administered NPWT. Patients were divided into two groups: Group 1 included patients who were treated with NPWT only, while Group 2 included patients who were treated with injectable ADM combined with NPWT. Clinical results including the number of NPWT dressing changes, wound healing duration, and full-thickness skin graft (FTSG) incident rate between the two groups were compared.
   Results: A total of 41 patients took part in the study (Group 1=20, Group 2=21). The mean number of NPWT dressing changes was significantly lower in Group 2 (8.71 +/- 3.77) than in Group 1 (13.90 +/- 5.62) (p=0.001). Mean wound healing period was shorter in Group 2 (3.17 +/- 1.36 weeks) than in Group 1 (5.47 +/- 1.68 weeks) (p=0.001). Finally, the rate of patients who underwent FTSG for complete wound closure was 85% in Group 1, whereas it was only 14.3% in Group 2.
   Conclusion: In this study, the use of injectable ADM combined with NPWT in patients with DFU who underwent amputation favoured complete wound healing, without the need to resort to the use of skin grafts.
C1 [Ahn, Jiyong; Park, Ho Youn; Hwang, Wonha] Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul, South Korea.
   [Shetty, Asode Ananthram] Canterbury Christ Church Univ, Fac Hlth & Social Sci, Chatham, Kent, England.
C3 Catholic University of Korea; Canterbury Christ Church University
RP Ahn, J (通讯作者)，Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul, South Korea.
EM ilmon@hanmail.net
RI Ahn, Jiyong/KDN-0493-2024
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NR 53
TC 5
Z9 5
U1 1
U2 14
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
BP 310
EP 320
DI 10.12968/jowc.2022.31.4.310
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6QX
UT WOS:000781598300005
PM 35404696
DA 2026-07-24
ER

PT J
AU Dornseifer, U
   Pfeiler, PP
   Kargl, L
   Moog, P
   Schilling, AF
   Ninkovic, M
AF Dornseifer, Ulf
   Pfeiler, Peter Paul
   Kargl, Lukas
   Moog, Philipp
   Schilling, Arndt F.
   Ninkovic, Milomir
TI Negative Pressure Wound Therapy in Free Muscle Flaps-Risk or Benefit?
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE free flap; negative pressure wound therapy; VAC; flap edema; flap
   perfusion
ID LOWER-EXTREMITY; DANGLING PROCEDURE; RECONSTRUCTION; MOBILIZATION;
   MICROCIRCULATION; COMPLICATIONS; SURGERY
AB Background Application of negative pressure wound therapy (NPWT) on free flaps not only reduces edema but also increases the pressure from outside. The impact of these opposite effects on flap perfusion remains elusive. This study evaluates the NPWT system's influence on macro- and microcirculation of free flaps and edema reduction to better assess the clinical value of this therapy in microsurgical reconstructions.Methods In this open-label, prospective cohort study, a total of 26 patients with free gracilis muscle flaps for distal lower extremity reconstruction were included. Flaps were covered with an NPWT (13 patients) or a conventional, fatty gauze dressing (13 patients) for 5 postoperative days (PODs). Changes in flap perfusion were analyzed by laser Doppler flowmetry, remission spectroscopy, and an implanted Doppler probe. Flap volume as a surrogate parameter for flap edema was evaluated by three-dimensional (3D) scans.Results No flap showed clinical evidence of circulatory disturbances. The groups showed significant differences in the dynamic of macrocirculatory blood flow velocity with an increase in the NPWT group and a decelerated flow in the control group from PODs 0 to 3 and PODs 3 to 5. No significant differences in microcirculation parameters were observed. 3D scans for estimation of edema development demonstrated significant differences in volume dynamics between the groups. Flap volume of the controls increased, while the volume in the NPWT group decreased during the first 5 PODs. The volume of NPWT-treated flaps decreased even further after NPWT removal from PODs 5 to 14 and significantly more than the flap volume in the control group.Conclusion NPWT is a safe form of dressing for free muscle flaps that enhances blood flow and results in a sustainable edema reduction. The use of NPWT dressings for free flaps should therefore be considered not only as a pure wound covering but also as a supportive therapy for free tissue transfer.
C1 [Dornseifer, Ulf; Pfeiler, Peter Paul; Kargl, Lukas] Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Munich, Germany.
   [Moog, Philipp] Tech Univ Munich, Clin Plast Reconstruct & Hand Surg, Klinikum Rechts Isar, Munich, Germany.
   [Schilling, Arndt F.] Univ Med Ctr Gottingen, Dept Trauma Surg Orthoped & Plast Surg, Gottingen, Germany.
   [Ninkovic, Milomir] Bogenhausen Acad Teaching Hosp, Dept Plast Reconstruct Hand & Burn Surg, Munich, Germany.
   [Dornseifer, Ulf] Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Sonnenstr 24-26, D-80331 Munich, Germany.
C3 Technical University of Munich; University of Gottingen; University of
   Gottingen Hospital; Munchen Klinik
RP Dornseifer, U (通讯作者)，Isar Klinikum, Dept Plast Reconstruct & Aesthet Surg, Sonnenstr 24-26, D-80331 Munich, Germany.
OI Schilling, Arndt/0000-0001-7022-1069
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NR 41
TC 14
Z9 16
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2024
VL 40
IS 03
BP 197
EP 204
DI 10.1055/a-2110-0421
EA JUL 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IX5M3
UT WOS:001037214700001
PM 37315931
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Whitty, JA
   Wagner, AP
   Kang, EVY
   Ellwood, D
   Chaboyer, W
   Kumar, S
   Clifton, VL
   Thalib, L
   Gillespie, BM
AF Whitty, Jennifer A.
   Wagner, Adam P.
   Kang, Evelyn
   Ellwood, David
   Chaboyer, Wendy
   Kumar, Sailesh
   Clifton, Vicki L.
   Thalib, Lukman
   Gillespie, Brigid M.
TI Cost-effectiveness of closed incision negative pressure wound therapy in
   preventing surgical site infection among obese women giving birth by
   caesarean section: An economic evaluation (DRESSING trial)
SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE caesarean section; cost-effectiveness; economic evaluation; negative
   pressure wound therapy; surgical site infection
ID MANAGEMENT; HEALTH
AB BackgroundThere is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS). AimTo assess the cost-effectiveness of ci-NPWT compared to standard dressings for prevention of SSI in obese women giving birth by CS. Materials and MethodsCost-effectiveness and cost-utility analyses from a health service perspective were undertaken alongside a multicentre pragmatic randomised controlled trial, which recruited women with a pre-pregnancy body mass index >= 30 kg/m(2) giving birth by elective/semi-urgent CS who received ci-NPWT (n = 1017) or standard dressings (n = 1018). Resource use and health-related quality of life (SF-12v2) collected during admission and for four weeks post-discharge were used to derive costs and quality-adjusted life years (QALYs). Resultsci-NPWT was associated with AUD$162 (95%CI -$170 to $494) higher cost per person and an additional $12 849 (95%CI -$62 138 to $133 378) per SSI avoided. There was no detectable difference in QALYs between groups; however, there are high levels of uncertainty around both cost and QALY estimates. There is a 20% likelihood that ci-NPWT would be considered cost-effective at a willingness-to-pay threshold of $50 000 per QALY. Per protocol and complete case analyses gave similar results, suggesting that findings are robust to protocol deviators and adjustments for missing data. Conclusionsci-NPWT for the prevention of SSI in obese women undergoing CS is unlikely to be cost-effective in terms of health service resources and is currently unjustified for routine use for this purpose.
C1 [Whitty, Jennifer A.; Wagner, Adam P.] Univ East Anglia, Norwich Med Sch, Norwich, England.
   [Whitty, Jennifer A.; Wagner, Adam P.] NIHR Appl Res Collaborat ARC East England EoE, Natl Inst Hlth Res, Cambridge, England.
   [Kang, Evelyn; Chaboyer, Wendy; Gillespie, Brigid M.] Griffith Univ, Menzies Hlth Inst, Natl Hlth & Med Res Council Ctr Res Excellence Wis, Gold Coast, Qld, Australia.
   [Ellwood, David; Gillespie, Brigid M.] Gold Coast Univ Hosp, Gold Coast Hlth, Southport, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia.
   [Kumar, Sailesh] Univ Queensland, Mater Mothers Hosp, Brisbane, Qld, Australia.
   [Clifton, Vicki L.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Thalib, Lukman] Istanbul Aydin Univ, Fac Med, Dept Biostat, Istanbul, Turkiye.
   [Whitty, Jennifer A.] Evidera, Ark, 2nd floor,201 Talgarth Rd, London W6 8BJ, England.
C3 University of East Anglia; University of Cambridge; Menzies Health
   Institute Queensland; Griffith University; Gold Coast University
   Hospital; Gold Coast Health; Griffith University; University of
   Queensland; Mater Health Services; Mater Mothers' Hospital; University
   of Queensland; Mater Research; Istanbul Aydin University; Evidera
RP Whitty, JA (通讯作者)，Evidera, Ark, 2nd floor,201 Talgarth Rd, London W6 8BJ, England.
EM jenny.whitty@evidera.com
RI Clifton, Vicki L/AAV-2749-2021; Kumar, Sailesh/M-3207-2014; Ellwood,
   David/C-8208-2015; Chaboyer, Wendy/F-9588-2018; Wagner,
   Adam/AAA-4346-2019; Gillespie, Brigid/E-7799-2012; Thalib,
   Lukman/HAI-7553-2022; Whitty, Jennifer/N-6434-2013
OI Clifton, Vicki L/0000-0002-4892-6748; Kumar,
   Sailesh/0000-0003-0832-4811; Ellwood, David/0000-0003-4512-6443;
   Chaboyer, Wendy/0000-0001-9528-7814; Wagner, Adam/0000-0002-9101-3477;
   Gillespie, Brigid/0000-0003-3186-5691; Thalib,
   Lukman/0000-0002-1211-6495; Whitty, Jennifer/0000-0002-5886-1933
FU Australian National Health and Medical Research Council [APP1081026];
   United Kingdom's (UK's) National Institute of Health Research (NIHR)
   Applied Research Collaboration East of England (ARC EoE) program
FX We thank all the women who took part, the wider research team, and staff
   members involved in the trial at the recruitment sites. The trial was
   funded by the competitive peer-reviewed grant (APP1081026) from the
   Australian National Health and Medical Research Council. Jennifer Whitty
   and Adam Wagner are supported by the United Kingdom's (UK's) National
   Institute of Health Research (NIHR) Applied Research Collaboration East
   of England (ARC EoE) program. The views expressed are those of the
   authors and not necessarily those of the UK's National Health Service
   (NHS), NIHR or Department of Health and Social Care.
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NR 29
TC 7
Z9 7
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8666
EI 1479-828X
J9 AUST NZ J OBSTET GYN
JI Aust. N. Z. J. Obstet. Gynaecol.
PD OCT
PY 2023
VL 63
IS 5
BP 673
EP 680
DI 10.1111/ajo.13677
EA MAY 2023
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA X4MP0
UT WOS:000990232600001
PM 37200473
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU DeFazio, MV
   Economides, JM
   Anghel, EL
   Mathis, RK
   Barbour, JR
   Attinger, CE
AF DeFazio, Michael V.
   Economides, James M.
   Anghel, Ersilia L.
   Mathis, Ryan K.
   Barbour, John R.
   Attinger, Christopher E.
TI Traction-assisted Internal Negative Pressure Wound Therapy With Bridging
   Retention Sutures to Facilitate Staged Closure of High-risk Wounds Under
   Tension
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE delayed primary closure; dermatotraction; negative pressure wound
   therapy; retention sutures; staged reconstruction
ID EXTERNAL TISSUE EXPANDER; OPEN ABDOMEN; HIDRADENITIS SUPPURATIVA;
   MANAGEMENT; SKIN; INSTILLATION; EXPANSION; DEFECTS; RESECTION; STRETCH
AB Background/Objective. Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. Materials and Methods. Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures. Instillation of antimicrobial solution was reserved for wounds containing infected/exposed hardware or prosthetic devices. Demographic data, wound characteristics, reconstructive outcomes, and complications were reviewed retrospectively. Results. Eighteen wounds were treated with traction-assisted internal NPWT using the conventional (n = 11) or modified instillation (n = 7) technique. Defects involved the lower extremity (n = 14), trunk (n = 3), and proximal upper extremity (n = 1), with positive cultures identified in 12 wounds (67%). Therapy continued for 3 to 8 days (mean, 4.3 days), resulting in an average wound surface area reduction of 78% (149 cm(2) vs. 33 cm2) at definitive closure. Seventeen wounds (94%) were closed directly, whereas the remaining defect required coverage with a local muscle flap and skin graft. At final follow-up (mean, 12 months), 89% of wounds remained closed. In 2 patients with delayed, recurrent peri-prosthetic infection (mean, 7.5 weeks), serial debridement/hardware removal mandated free tissue transfer for composite defect reconstruction. Conclusions. Traction-assisted internal NPWT provides a safe and effective alternative to reduce wound burden and facilitate definitive closure in cases where delayed reconstruction of high-tension wounds is planned.
C1 [DeFazio, Michael V.; Economides, James M.; Anghel, Ersilia L.; Mathis, Ryan K.; Barbour, John R.; Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Ctr Wound Healing, Dept Plast Surg, Washington, DC USA.
C3 Georgetown University
RP DeFazio, MV (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW,1 PHC, Washington, DC 20007 USA.
EM Michael.V.DeFazio@gunet.georgetown.edu
RI Economides, James/L-1438-2019
CR Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
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NR 37
TC 10
Z9 12
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2017
VL 29
IS 10
BP 289
EP +
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FV2BR
UT WOS:000424369500005
PM 28873059
DA 2026-07-24
ER

PT J
AU De Vries, FEE
   Wallert, ED
   Solomkin, JS
   Allegranzi, B
   Egger, M
   Dellinger, EP
   Boermeester, MA
AF De Vries, Fleur E. E.
   Wallert, Elon D.
   Solomkin, Joseph S.
   Allegranzi, Benedetta
   Egger, Matthias
   Dellinger, E. Patchen
   Boermeester, Marja A.
TI A systematic review and meta-analysis including GRADE qualification of
   the risk of surgical site infections after prophylactic negative
   pressure wound therapy compared with conventional dressings in clean and
   contaminated surgery
SO MEDICINE
LA English
DT Review
DE incisional wound therapy; prevention; prophylactic negative pressure
   wound therapy; surgical site infection; wound infections
ID CESAREAN-SECTION; PREVENTION; INCISIONS; COST; COMPLICATIONS;
   MANAGEMENT; VACUUM
AB Objective:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs).Introduction:pNPWT has been suggested as a new method to prevent wound complications, specifically SSIs, by its application on closed incisional wounds.Methods:This review was conducted as part of the development of the Global Guidelines for prevention of SSIs commissioned by World Health Organization in Geneva. PubMed, Embase, CENTRAL, CINAHL, and the World Health Organization database between January 1, 1990 and October 7, 2015 were searched. Inclusion criteria were randomized controlled trials and observational studies comparing pNPWT with conventional wound dressings and reporting on the incidence of SSI. Meta-analyses were performed with a random effect model. GRADE Pro software was used to qualify the evidence.Results:Nineteen articles describing 21 studies (6 randomized controlled trials and 15 observational) were included in the review. Summary estimate showed a significant benefit of pNPWT over conventional wound dressings in reducing SSIs in both randomized controlled trials and observational studies, odds ratio of 0.56 (95% confidence interval, 0.32-0.96; P = 0.04) and odds ratio of 0.30 (95% confidence interval, 0.22-0.42; P<0.00001), respectively. This translates into lowering the SSI rate from 140 to 83 (49-135) per 1000 patients and from 106 to 34 (25-47) per 1000 patients, respectively. In stratified analyses, these results were consistent in both clean and clean-contaminated procedures and in different types of surgery, however results were no longer significant for orthopaedic/trauma surgery. The level of evidence as qualified with GRADE was however low.Conclusions:Low-quality evidence indicates that prophylactic NPWT significantly reduces the risk of SSIs.
C1 [De Vries, Fleur E. E.; Wallert, Elon D.; Boermeester, Marja A.] Acad Med Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands.
   [Solomkin, Joseph S.] Univ Cincinnati, Coll Med, Dept Surg, Cincinnati, OH USA.
   [Allegranzi, Benedetta] WHO, Serv Delivery & Safety, Infect Prevent & Control Global Unit, Geneva, Switzerland.
   [Egger, Matthias] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland.
   [Dellinger, E. Patchen] Univ Washington, Dept Surg, Seattle, WA 98195 USA.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   System of Ohio; University of Cincinnati; World Health Organization;
   University of Bern; University of Washington; University of Washington
   Seattle
RP De Vries, FEE (通讯作者)，Acad Med Ctr, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM f.e.devries@amc.uva.nl
RI ; Dellinger, E./AFZ-2144-2022; Wallert, Elon/HQZ-0375-2023
OI Egger, Matthias/0000-0001-7462-5132; Solomkin,
   Joseph/0000-0001-6382-4902; Boermeester, Marja/0000-0003-3890-8105; 
FU Merck; Ortho-McNeil; Targanta; Schering-Plough; Astellas; Allergan; Care
   Fusion; Durata; Pfizer; Applied Medical; Rib-X; Affinium; Tetraphase;
   Televancin; R-Pharm; Cubist; Melinta; 3M; Motif; JJ/Ethicon; Acelity;
   Ipsen; Baxter; Mylan
FX EPD reports personal fees from Merck, Ortho-McNeil, Targanta,
   Schering-Plough, Astellas, Allergan, Care Fusion, Durata, Pfizer,
   Applied Medical, Rib-X, Affinium, Tetraphase, Televancin, R-Pharm,
   Cubist, Melinta, 3M and grants from Motif, outside the submitted work.
   MAB reports institutional grants from J&J/Ethicon, Acelity, Ipsen,
   Baxter, Mylan, outside the submitted work; advisory board member of
   J&J/Ethicon and Acelity.
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NR 45
TC 75
Z9 84
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2016
VL 95
IS 36
AR e4673
DI 10.1097/MD.0000000000004673
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DX4JE
UT WOS:000384346200031
PM 27603360
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sezikli, I
   Topcu, R
   Kendirci, M
AF Sezikli, Ismail
   Topcu, Ramazan
   Kendirci, Murat
TI Negative pressure wound therapy in high-risk gastrointestinal surgery: a
   retrospective cohort study on postoperative complications
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Negative pressure wound therapy; Traditional wound management;
   Complications; Surgery; High-risk gastrointestinal patients
ID SURGICAL SITE INFECTIONS; LAPAROTOMY; DRESSINGS
AB BackgroundSurgical site infections (SSIs) are a significant cause of morbidity in colorectal surgeries, mainly due to the contaminated nature of these procedures. Traditional wound management techniques have limitations, leading to prolonged hospital stays and increased healthcare costs. Negative pressure wound therapy (NPWT) has emerged as an advanced method for managing surgical wounds, promoting faster healing by enhancing tissue perfusion, reducing edema, and managing wound exudate. This retrospective cohort study aims to compare the outcomes of NPWT with those of conventional wound care in patients undergoing high-risk gastrointestinal surgeries.MethodsA total of 141 patients classified as having contaminated or dirty wounds were divided into two groups: the NPWT group (47 patients) and the conventional wound care group (94 patients). Postoperative outcomes, including SSIs, wound healing, dehiscence, and incisional hernia development, were monitored at 1 month and 1 year.ResultsThe results revealed a significant reduction in superficial SSIs in the NPWT group (6.4% vs. 18.1%, p = 0.04), along with shorter hospital stays (8.9 vs. 11.2 days, p = 0.01). Incisional hernia rates were also significantly lower in the NPWT group at both 1 month (6.4% vs. 12.8%, p = 0.05) and 1 year (6.4% vs. 16.0%, p = 0.03). While the reduction in deep SSIs did not reach statistical significance (2.1% vs. 9.6%, p = 0.08), the observed trend suggests further investigation.ConclusionThis study demonstrated that NPWT not only reduces the incidence of SSIs and hospital stays but also decreases the long-term incidence of incisional hernias. These findings suggest that NPWT should be considered a standard approach for managing high-risk surgical wounds, especially in gastrointestinal procedures, where infection risks are inherently greater.
C1 [Sezikli, Ismail; Topcu, Ramazan; Kendirci, Murat] Hitit Univ, Fac Med, Dept Gen Surg, TR-19030 Corum, Turkiye.
C3 Hitit University
RP Topcu, R (通讯作者)，Hitit Univ, Fac Med, Dept Gen Surg, TR-19030 Corum, Turkiye.
EM topcur58@gmail.com
RI TOPCU, RAMAZAN/GVS-3968-2022; Kendirci, Murat/KIK-6978-2024; Sezikli,
   İsmail/IXD-3740-2023
OI TOPCU, RAMAZAN/0000-0001-6214-4868; Sezikli, İsmail/0000-0002-6801-1465
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe276, DOI [10.1016/s1473-3099(16)30402-9, 10.1016/s1473-3099(16)30398-x, 10.1016/S1473-3099(16)30398-X]
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 27
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD OCT 16
PY 2025
VL 25
IS 1
AR 739
DI 10.1186/s12876-025-04377-x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 8SY7A
UT WOS:001596593600003
PM 41102671
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Harris, KT
   Hwang, C
   Caldwell, B
   Vemulakonda, V
   Wood, D
   Wilcox, DT
   Rove, KO
AF Harris, Kelly T.
   Hwang, Catalina
   Caldwell, Brian
   Vemulakonda, Vijaya
   Wood, Dan
   Wilcox, Duncan T.
   Rove, Kyle O.
TI Use of incisional negative pressure wound therapy in reconstructive
   pediatric and young adult urology to reduce surgical site occurrences: A
   pilot study
SO JOURNAL OF PEDIATRIC UROLOGY
LA English
DT Article
DE Patient safety; Quality improvement; Wound compli-cation; Reconstructive
   surgery; Incisional negative pressure wound therapy
ID RISK-FACTORS; INFECTION; EPIDEMIOLOGY; SURGERY
AB Background Surgical site occurrences (SSO) contribute to the morbidity and cost of postoperative complications. In adult and pediatric surgical literature, enthusiasm for incisional negative pressure wound therapy (iNPWT) on closed surgical incisions has been ongoing. Objective The aim of this pilot study is to report the early outcomes of iNPWT in reconstructive pediatric and young adult urologic surgery. Study design This is a pilot prospective cohort study at a single, tertiary care, free-standing children's hospital. Wound complication outcomes with use of iNPWT are compared to a historical cohort that underwent routine incision closures. A multivariate logistic regression model was used to predict the risk of composite SSO within the first 30 days after surgery. Results On univariate analysis, the percentage of patients experiencing SSO fell from 24.0 % to 6.9 % with introduction of iNPWT (p = 0.065). On multivariate analysis, compared to the pre-iNPWT group, placement of iNPWT was associated with a reduction in risk of composite SSO [OR 0.084 (0.009-0.415, p = 0.01]. Discussion Strengths of this study are that it was prospective in nature and there was consistency in iNPWT placement and management throughout the study period. Until more reliable biological markers of SSO risk are available, we believe that interventions to prevent SSO must be broadly applied. One limitation is that the financial and physical cost of having an iNPWT placed could not be measured for each individual patient. Conclusion In this pilot study, iNPWT was found to be a successful intervention to reduce SSO in reconstructive pediatric and young adult urology patients. Use of iNPWT could be considered for all, but perhaps particularly in those with a baseline high risk of SSO, including those with obesity or connective tissue disorders.
C1 [Harris, Kelly T.; Hwang, Catalina; Caldwell, Brian; Vemulakonda, Vijaya; Wood, Dan; Wilcox, Duncan T.; Rove, Kyle O.] Childrens Hosp Colorado, Dept Pediat Urol, Pediat Urol Res Enterprise, Aurora, CO USA.
   [Harris, Kelly T.; Hwang, Catalina; Caldwell, Brian; Vemulakonda, Vijaya; Wood, Dan; Wilcox, Duncan T.; Rove, Kyle O.] Dept Surg, Div Urol, Anschutz Med Campus, Aurora, CO USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz
RP Harris, KT (通讯作者)，Childrens Hosp Colorado, Dept Pediat Urol, 13123 East 16th Ave, Aurora, CO 80054 USA.
EM kelly.harris2@childrenscolorado.org
RI /AAO-9922-2020
OI Rove, Kyle/0000-0002-2323-4139
FU Pediatric Urology Research Enterprise (PURE) , Pediatric Urology,
   Children's Hospital Colorado
FX The research was supported by the Pediatric Urology Research Enterprise
   (PURE) , Pediatric Urology, Children's Hospital Colorado.
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NR 16
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1477-5131
EI 1873-4898
J9 J PEDIATR UROL
JI J. Pediatr. Urol
PD OCT
PY 2025
VL 21
IS 5
BP 1306
EP 1312
DI 10.1016/j.jpurol.2025.03.001
EA OCT 2025
PG 7
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA 8UJ9D
UT WOS:001597571400014
PM 40089427
DA 2026-07-24
ER

PT J
AU Rezk, F
   Åstrand, H
   Svensson-Björk, R
   Hasselmann, J
   Nyman, J
   Butt, T
   Bilos, L
   Pirouzram, A
   Acosta, S
AF Rezk, Francis
   Astrand, Hakan
   Svensson-Bjork, Robert
   Hasselmann, Julien
   Nyman, Johan
   Butt, Talha
   Bilos, Linda
   Pirouzram, Artai
   Acosta, Stefan
TI Multicenter parallel randomized trial evaluating incisional negative
   pressure wound therapy for the prevention of surgical site infection
   after lower extremity bypass
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Incisional negative pressure wound therapy; Lower extremity bypass;
   Surgical site infection; Wound dehiscence
ID ARTERIAL RECONSTRUCTION; ANTIBIOTIC-PROPHYLAXIS; COMPLICATIONS;
   ISCHEMIA; TRIMETHOPRIM/SULFAMETHOXAZOLE; REVASCULARIZATION;
   METAANALYSIS; MANAGEMENT
AB Objective: Incisional negative pressure wound therapy (iNPWT) applied over all incisions after lower extremity bypass in the prevention of surgical site infections (SSIs) is unclear. The primary and secondary aims of this study were to investigate if prophylactic iNPWT after the elective lower extremity bypass prevents SSI and other surgical wound complications. Methods: This was a multicenter, parallel, randomized controlled trial. Patients undergoing elective lower extremity bypass in 3 hospitals were randomized to either iNPWT or standard dressings. SSIs or other wound complications were assessed within the fi rst 90 days by wound care professionals blinded to the randomized result. The validated Additional treatment, Serous discharge, Erythema, Purulent exudate, Separation of deep tissues, Isolation of bacteria, and Stay (ASEPSIS) score was used to objectively assess the wounds. ASEPSIS score $ 21 is de fi ned as an SSI. Unilateral and bilateral groups were analyzed with the Fisher exact test and the McNemar test, respectively. Results: In the unilateral group (n = 100), the incidence of SSI in the iNPWT group was 34.9% (15/43), compared with 40.3% (23/57) in the control group, according to the ASEPSIS score ( P = .678). In the bilateral group (n = 7), the SSI rate was 14.3% (1/7) in the iNPWT group compared with 14.3% (1/7) in the control group ( P = 1.00). In the unilateral group, there was a higher wound dehiscence rate in the control group (43.9%) compared with the iNPWT group (23.3%) ( P = .0366). No serious iNPWT-related adverse events were recorded. Conclusions: There was no reduction of SSI rates in leg incisions with iNPWT compared with standard dressings in patients undergoing elective lower extremity bypass, whereas iNPWT reduced the incidence of wound dehiscence.
C1 [Rezk, Francis; Svensson-Bjork, Robert; Hasselmann, Julien; Nyman, Johan; Butt, Talha; Acosta, Stefan] Lund Univ, Dept Clin Sci, SE-20502 Malmo, Sweden.
   [Rezk, Francis; Astrand, Hakan] Reg Jonkoping Cty, Dept Surg, Jonkoping, Sweden.
   [Nyman, Johan; Butt, Talha] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Malmo, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ Hosp, Dept Cardiothorac & Vasc Surg, Linkoping, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Linkoping
   University; Linkoping University
RP Rezk, F (通讯作者)，Lund Univ, Dept Clin Sci, SE-20502 Malmo, Sweden.
EM francis.rezk@med.lu.se
RI ; Acosta, Stefan/JAX-3225-2023
OI Rezk, Francis/0000-0002-1236-6363; Acosta, Stefan/0000-0002-3225-0798;
   Butt, Talha/0000-0001-8443-2035
FU Lund University; Swedish Medical Research Council [2019-00435]; Hulda
   Almroth Foundation; Swedish government under the ALF agreement; Region
   Skane; Skane University Hospital; Swedish Research Council [2019-00435]
   Funding Source: Swedish Research Council
FX Open-access funding is provided by Lund University. Research funds were
   received from the Swedish Medical Research Council (2019-00435) , the
   Hulda Almroth Foundation, Skane University Hospital, Region Skane, and
   the Swedish government under the ALF agreement.
CR Acosta S, 2013, ClinicalTrials.gov
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NR 43
TC 4
Z9 4
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2024
VL 79
IS 4
DI 10.1016/j.jvs.2023.11.043
EA MAR 2024
PG 14
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA QC4M5
UT WOS:001218667300001
PM 38042513
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Diehm, YF
   Fischer, S
   Gazyakan, E
   Hundeshagen, G
   Kotsougiani-Fischer, D
   Falkner, F
   Kneser, U
   Hirche, C
AF Diehm, Yannick F.
   Fischer, Sebastian
   Gazyakan, Emre
   Hundeshagen, Gabriel
   Kotsougiani-Fischer, Dimitra
   Falkner, Florian
   Kneser, Ulrich
   Hirche, Christoph
TI Negative pressure wound therapy as an accelerator and stabilizer for
   incorporation of artificial dermal skin substitutes - A retrospective,
   non-blinded, and non-randomized comparative study
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Artificial dermal skin substitutes (ADSS); Negative pressure wound
   therapy (NPWT); Split thickness skin graft; Success rate;
   Vascularization
ID REGENERATION TEMPLATE; INTEGRA; RECONSTRUCTION; DEFECTS; DEVICE; BURNS
AB Background: Artificial dermal skin substitutes (ADSS) in combination with split-thickness skin grafts (STSG) are a valuable option for reconstruction of skin- and soft tissue-defects. However, successful incorporation of ADSS can be limited by various factors. We investigated the anticipated benefits of negative pressure wound therapy (NPWT) as an adjunct to support integration of ADSS, in a retrospective, comparative cohort study.
   Patients and methods: We performed a retrospective, non-blinded, non-randomized comparative study including 86 patients with various soft-tissue defects, managed by application of either ADSS with or without NPWT based on the surgeon's preference. Outcome measurements comprised ADSS and skin graft take rates and analysis of treatment duration and time to wound healing. Additionally, patients were analyzed for the occurrence of hematoma, seroma, wound infection, and lack of substitute or skin graft adhesion.
   Results: Demographic data and individual risk factors did not differ with statistical significance between both groups. The combination of ADSS with NPWT led to significantly improved rates of ADSS integration (89 vs. 70.1%; p = 0.035) and skin graft take (91 vs. 76%; p = 0.049) compared to standard wound dressings without NPWT. In addition, while differences in the incidence of seroma were neglectable, NPWT application led to significantly reduced rates of infection of ADSS (2.2 vs. 7.3%; p = 0.043). Moreover, STSG could be performed on average 4 days earlier with the application of NPWT (p = 0.031).
   Conclusions: The addition of NPWT to ADSS is a helpful adjunct that reduces time of incorporation and vascularization and improves clinical success rates. (C) 2020 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Diehm, Yannick F.; Fischer, Sebastian; Gazyakan, Emre; Hundeshagen, Gabriel; Kotsougiani-Fischer, Dimitra; Falkner, Florian; Kneser, Ulrich; Hirche, Christoph] Heidelberg Univ, Burn Trauma Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg
RP Hirche, C (通讯作者)，Heidelberg Univ, Trauma Ctr Ludwigshafen, Burn Trauma Ctr, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
EM Christoph.Hirche@bgu-ludwigshafen.de
RI Gazyakan, Emre/HLW-5585-2023; Fischer, Sebastian/AEX-5429-2022
OI , Sebastian/0000-0003-3445-1902
CR BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Cunningham T, 2014, DERMATOL SURG, V40, pS120, DOI 10.1097/DSS.0000000000000113
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   Fraccalvieri M, 2012, INT WOUND J, V9, P214, DOI 10.1111/j.1742-481X.2011.00878.x
   Gonzalez Alana I, 2013, ANN BURNS FIRE DISAS, V26, P90
   HEIMBACH D, 1988, ANN SURG, V208, P313, DOI 10.1097/00000658-198809000-00008
   Heimbach DM, 2003, J BURN CARE REHABIL, V24, P42, DOI 10.1097/00004630-200301000-00009
   Iorio ML, 2012, PLAST RECONSTR SURG, V130, p232S, DOI 10.1097/PRS.0b013e3182615703
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Jeschke MG, 2003, DEP GEN SURG TRAUMA, P525
   Lohana P, 2014, Ann Burns Fire Disasters, V27, P17
   Milcheski DA, 2014, PRS-GLOB OPEN, V2, DOI 10.1097/GOX.0000000000000108
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Ryssel H, 2008, BURNS, V34, P93, DOI 10.1016/j.burns.2007.01.018
   Schiavon M, 2016, AESTHET PLAST SURG, V40, P901, DOI 10.1007/s00266-016-0703-0
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NR 18
TC 24
Z9 28
U1 0
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD FEB
PY 2021
VL 74
IS 2
BP 357
EP 363
DI 10.1016/j.bjps.2020.08.041
EA JAN 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TC4DR
UT WOS:000668591700013
PM 32893153
DA 2026-07-24
ER

PT J
AU Hyldig, N
   Joergensen, JS
   Wu, C
   Bille, C
   Vinter, CA
   Sorensen, JA
   Mogensen, O
   Lamont, RF
   Möller, S
   Kruse, M
AF Hyldig, N.
   Joergensen, J. S.
   Wu, C.
   Bille, C.
   Vinter, C. A.
   Sorensen, J. A.
   Mogensen, O.
   Lamont, R. F.
   Moller, S.
   Kruse, M.
TI Cost-effectiveness of incisional negative pressure wound therapy
   compared with standard care after caesarean section in obese women: a
   trial-based economic evaluation
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Caesarean section; cost-effectiveness; economic evaluation; incisional
   negative pressure wound therapy; obesity; quality-adjusted life-years;
   surgical site infection
ID SURGICAL SITE INFECTION; RISK-FACTORS; METAANALYSIS; VACUUM
AB Objective To evaluate the cost-effectiveness of incisional negative pressure wound therapy (iNPWT) in preventing surgical site infection in obese women after caesarean section. Design A cost-effectiveness analysis conducted alongside a clinical trial. Setting Five obstetric departments in Denmark. Population Women with a pregestational body mass index (BMI) >= 30 kg/m(2). Method We used data from a randomised controlled trial of 876 obese women who underwent elective or emergency caesarean section and were subsequently treated with iNPWT (n = 432) or a standard dressing (n = 444). Costs were estimated using data from four Danish National Databases and analysed from a healthcare perspective with a time horizon of 3 months after birth. Main outcome measures Cost-effectiveness based on incremental cost per surgical site infection avoided and per quality-adjusted life-year (QALY) gained. Results The total healthcare costs per woman were euro5793.60 for iNPWT and euro5840.89 for standard dressings. Incisional NPWT was the dominant strategy because it was both less expensive and more effective; however, no statistically significant difference was found for costs or QALYs. At a willingness-to-pay threshold of euro30,000, the probability of the intervention being cost-effective was 92.8%. A subgroup analysis stratifying by BMI shows that the cost saving of the intervention was mainly driven by the benefit to women with a pre-pregnancy BMI >= 35 kg/m(2). Conclusion Incisional NPWT appears to be cost saving compared with standard dressings but this finding is not statistically significant. The cost savings were primarily found in women with a pre-pregnancy BMI >= 35 kg/m(2).
C1 [Hyldig, N.; Bille, C.; Sorensen, J. A.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Plast Surg, Odense, Denmark.
   [Hyldig, N.; Joergensen, J. S.; Wu, C.; Vinter, C. A.; Lamont, R. F.] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Obstet & Gynaecol, Odense, Denmark.
   [Hyldig, N.; Moller, S.] Odense Univ Hosp, OPEN Odense Patient Data Explorat Network, Odense, Denmark.
   [Mogensen, O.] Karolinska Univ Hosp, Div Pelv Canc, Stockholm, Sweden.
   [Mogensen, O.] Karolinska Inst, Stockholm, Sweden.
   [Lamont, R. F.] UCL, Div Surg, London, England.
   [Moller, S.] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
   [Kruse, M.] Univ Southern Denmark, Dept Publ Hlth, Danish Ctr Hlth Econ DaCHE, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; Karolinska Institutet; Karolinska
   University Hospital; Karolinska Institutet; University of London;
   University College London; University of Southern Denmark; University of
   Southern Denmark
RP Hyldig, N (通讯作者)，Odense Univ Hosp, JB Winslows Vej 9 A,3 Floor, DK-5000 Odense C, Denmark.
EM nana.hyldig@rsyd.dk
RI Sørensen, Jens Ahm/D-6279-2014; Möller, Sören/X-8738-2019; Hyldig,
   Nana/AAH-5220-2020; Mogensen, Ole/Q-1894-2015
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Möller,
   Sören/0000-0003-0858-4269; Hyldig, Nana/0000-0001-6758-6294; Mogensen,
   Ole/0000-0001-7655-9909; jørgensen, jan stener/0000-0001-5222-2535;
   Vinter, Christina Anne/0000-0001-5084-6053
FU University of Southern Denmark; Odense University Hospital; Region of
   Southern Denmark; Lundbeckfonden; iNPWT device manufacturer Smith
   Nephew; Steno Diabetes Center Odense (SDCO) [SDCO Research 002] Funding
   Source: researchfish
FX The RCT was funded by grants from the University of Southern Denmark,
   Odense University Hospital, the Region of Southern Denmark,
   Lundbeckfonden, and an unrestricted grant from the iNPWT device
   manufacturer Smith& Nephew. None of these sources of funds had influence
   on study design, data collection, data analyses, interpretation of
   results, or on the writing of the report.
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NR 35
TC 34
Z9 37
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD APR
PY 2019
VL 126
IS 5
BP 619
EP 627
DI 10.1111/1471-0528.15573
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HN7AY
UT WOS:000460341700015
PM 30507022
OA Green Accepted, Bronze
DA 2026-07-24
ER

PT J
AU Dal Pos, S
   Tafaj, S
   Hoxhaj, I
   Cassalia, F
   Russano, F
   Tropea, S
   Del Fiore, P
   Mazza, M
AF Dal Pos, Silvia
   Tafaj, Stela
   Hoxhaj, Ilda
   Cassalia, Fortunato
   Russano, Francesco
   Tropea, Saveria
   Del Fiore, Paolo
   Mazza, Marcodomenico
TI The Safety of Negative-Pressure Wound Therapy in Melanoma and Sarcoma
   Patients: A Systematic Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE negative-pressure wound therapy; melanoma; sarcoma; malignant wounds
ID SOFT-TISSUE SARCOMAS; ACRAL LENTIGINOUS MELANOMA; EXCISION;
   RECONSTRUCTION; DRESSINGS; RESECTION
AB Background/Objectives: Negative-Pressure Wound Therapy (NPWT) is increasingly used to promote wound healing in chronic and complicated wounds, but its use in surgical oncology is still debated due to theoretical concerns about promoting local tumor recurrence. The aim of this study is to review the available evidence on the oncologic safety of NPWT, specifically regarding the risk of local recurrence in patients undergoing surgery for cutaneous melanoma (CM) or soft tissue sarcoma (STS). Methods: A systematic review of the literature was conducted using the MEDLINE/PubMed, EMBASE, and Scopus databases through December 2024 (PROSPERO: CRD42024623405). Case series, retrospective cohort studies, and randomized clinical trials reporting survival data in melanoma and sarcoma patients treated with NPWT were eligible for inclusion. PRISMA guidelines were followed and quality assessment checked. Results: Seventeen studies were eligible for the analysis with a total of 285 patients, 197 affected by soft tissue sarcoma and 88 by cutaneous melanoma. The pooled proportion of local recurrence was 5% in patients treated with NPWT, regardless of the histology considered (STS and CM). When comparing NPWT to conventional wound therapy, both the pooled risk ratio (0.87; 95% CI: 0.24-3.11; Tau2 = 0.14; I2 = 8%) and odds ratio (0.83; 95% CI: 0.20-3.39; Tau2 = 0.18) indicated no statistically significant difference in the recurrence rate. Conclusions: Current evidence does not suggest an increased risk of local recurrence associated with NPWT in melanoma or sarcoma patients, and mostly, NPWT may have important advantages over standard surgical dressings. More high-power randomized controlled trials with wider follow-up periods are needed to make it possible for practitioners to use this technique without being afraid of higher risk local recurrences.
C1 [Dal Pos, Silvia; Russano, Francesco; Tropea, Saveria; Del Fiore, Paolo; Mazza, Marcodomenico] Veneto Inst Oncol IOV IRCCS, Soft Tissue Peritoneum & Melanoma Surg Oncol Unit, I-35128 Padua, Italy.
   [Tafaj, Stela] Univ Padua, Dept Surg Oncol & Gastroenterol Sci DISCOG, I-35128 Padua, Italy.
   [Hoxhaj, Ilda] Fdn Policlin Univ Agostino Gemelli, Ist Ricovero & Cura Carattere Sci IRCCS, Dept Med & Surg Sci, I-00168 Rome, Italy.
   [Cassalia, Fortunato] Univ Padua, Dept Med DIMED, Dermatol Unit, I-35121 Padua, Italy.
C3 IRCCS Istituto Oncologico Veneto (IOV); University of Padua; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; University of
   Padua
RP Del Fiore, P (通讯作者)，Veneto Inst Oncol IOV IRCCS, Soft Tissue Peritoneum & Melanoma Surg Oncol Unit, I-35128 Padua, Italy.
EM silvia.dalpos@iov.veneto.it; paolo.delfiore@iov.veneto.it;
   marcodomenico.mazza@iov.veneto.it
RI HOXHAJ, Ilda/JFB-1110-2023; Del Fiore, Paolo/X-7536-2018; Cassalia,
   Fortunato/ITV-9685-2023; mazza, marcodomenico/KAL-9409-2024
OI HOXHAJ, Ilda/0000-0001-7086-2456; Del Fiore, Paolo/0000-0002-2862-8014;
   Cassalia, Fortunato/0000-0002-5014-1122; mazza,
   marcodomenico/0000-0002-4575-0548
FU Italian Ministry of Health
FX This research received no external funding, and the APC was funded by
   "Current Research" funds from the Italian Ministry of Health to cover
   publication.
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NR 36
TC 0
Z9 0
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT 5
PY 2025
VL 14
IS 19
AR 7044
DI 10.3390/jcm14197044
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8OS9X
UT WOS:001593717400001
PM 41096124
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Moeng, MS
   Vadia, S
   Collinsworth, AW
   Lookess, S
   Capelli, P
AF Moeng, Maeyane S.
   Vadia, Suleman
   Collinsworth, Ashley W.
   Lookess, Siobhan
   Capelli, Paolo
TI Effect of Negative Pressure Wound Therapy with Instillation and Dwell
   Time on Health Care Utilization and Costs in South Africa
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE wound healing; health care utilization; health care; costs; negative
   pressure wound therapy with instillation and dwell time
AB Background. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) provides repeated wound cleansing plus the therapeutic benefits of traditional NPWT and has been elevated to a first-line therapy in some regions given evidence of its effectiveness. Objective. To examine the effect of NPWTi-d on health care utilization and costs in South Africa, where NPWTi-d may still be used as a therapy of last resort. Methods. This retrospective study was conducted utilizing a large, South African, private health insurance claims database. A matched cohort of 836 inpatients receiving NPWTi-d or NPWT for various wound types from 2018 through 2022 was created using propensity scoring. Differences in outcomes were compared between groups using t tests. Results. Despite matching, patients who received NPWTi-d were likely more complex than those who received NPWT, as indicated by a longer length of stay (18.5 days and 13.2 days, respectively; P < .001) and higher overall care costs during the index hospital admission. Readmission rates were similar between groups; however, patients who received NPWTi-d were less likely to have visits for wound-related subacute care or rehabilitation (20.1% vs 53.6%). The average cost of this care (in South African rand) was significantly lower for patients receiving NPWTi-d than for those receiving NPWT (R3 231 and R12 317, respectively; P < .001). Conclusion. Although this study had limitations, including a potential selection bias, study data suggest that NPWTi-d may reduce wound-related health care utilization and costs for some patients through decreases in visits for subacute care. More studies are needed to fully assess how NPWTi-d affects wound care pathways, patient outcomes, and costs in South Africa.
C1 [Moeng, Maeyane S.] Univ Witwatersrand, Johannesburg, South Africa.
   [Vadia, Suleman] Netcare Milpark Hosp, Johannesburg, South Africa.
   [Collinsworth, Ashley W.; Lookess, Siobhan; Capelli, Paolo] Solventum, Maplewood, MN USA.
C3 University of Witwatersrand
RP Collinsworth, AW (通讯作者)，12930 W Interstate 10, San Antonio, TX 78249 USA.
EM ACollinsworth@solventum.com
RI Moeng, Maeyane/OPN-3614-2025
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2025
VL 37
IS 10
BP 409
EP 416
DI 10.25270/wnds/25004
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G4712
UT WOS:001624575100005
PM 41270202
DA 2026-07-24
ER

PT J
AU Bota, O
   Martin, J
   Hammer, A
   Scherpf, M
   Matschke, K
   Dragu, A
   Malberg, H
AF Bota, Olimpiu
   Martin, Judy
   Hammer, Alexander
   Scherpf, Matthieu
   Matschke, Klaus
   Dragu, Adrian
   Malberg, Hagen
TI Topical negative pressure wound therapy enhances the local tissue
   perfusion - A pilot study
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Spectrophotometry; White light spectrometry; Laser Doppler spectroscopy;
   Topical negative pressure wound therapy; Cutaneous microcirculation;
   Tissue perfusion
ID LASER-DOPPLER; BLOOD-FLOW; ANOVA
AB Background: Topical negative pressure wound therapy (TNPWT) is a regularly used method in modern wound treatment with a growing and diverse potential for clinical use. So far positive effects on microcirculation have been observed and examined, although precise statements on the underlying mechanism appear unsatisfying.
   Objective: The aim of our study was to extend the understanding of the effect of TNPWT on tissue perfusion and determine the time frame and the extent to which the tissue perfusion changes due to TNPWT.
   Material and methods: TNPWT was applied to the anterior thighs of 40 healthy individuals for 30 min, respectively. Before and up to 90 min after the application, measurements of the amount of regional haemoglobin (rHb), capillary venous oxygen saturation (sO2), blood flow (flow) and velocity were conducted with spectrophotometry (combining white light spectrometry and laser Doppler spectroscopy) within two different depths/skin layers. A superficial measuring probe for depths up to 3 mm and a deep measuring probe for up to 7 mm were used.
   Results: All parameters show significant changes after the intervention compared to baseline measurements. The greater effect was seen superficially. The superficially measured rHb, sO2 and flow showed a significant increase and stayed above the baseline at the end of the protocol. Whereas deeply measured, the rHb initially showed a decrease. The flow and sO2 showed a significant increase up to 60 min after the intervention.
   Conclusion: The application of TNPWT on healthy tissue shows an increase in capillary-venous oxygen saturation and haemoglobin concentration of at least 90 min after intervention. A possible use in clinical practice for preconditioning to enhance wound healing for high-risk patients to develop wound healing disorder, requires further studies to investigate the actual duration of the effect.
C1 [Bota, Olimpiu; Martin, Judy; Dragu, Adrian] Tech Univ Dresden, Fac Med Carl Gustav Carus, Univ Ctr Orthoped, Fetscherstr 74, D-01307 Dresden, Germany.
   [Hammer, Alexander; Scherpf, Matthieu; Malberg, Hagen] Tech Univ Dresden, Inst Biomed Engn, Fetscherstr 29, D-01307 Dresden, Germany.
   [Matschke, Klaus] Tech Univ Dresden, Dept Cardiac Surg, Univ Heart Ctr Dresden, Fetscherstr 76, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Technische Universitat Dresden;
   Technische Universitat Dresden
RP Bota, O (通讯作者)，Tech Univ Dresden, Fac Med Carl Gustav Carus, Univ Ctr Orthoped, Fetscherstr 74, D-01307 Dresden, Germany.
EM olimpiu.bota@uniklinikum-dresden.de
RI Bota, Olimpiu/AAN-4292-2021; Scherpf, Matthieu/AFI-8411-2022; Hammer,
   Alexander/LUY-9375-2024; Dragu, Adrian/AAH-3506-2019
OI Bota, Olimpiu/0000-0002-5836-1269; Scherpf,
   Matthieu/0000-0001-6754-5257; Hammer, Alexander/0000-0002-1984-580X;
   Dragu, Adrian/0000-0003-4633-2695
FU European Regional Development Fund [F-003661-553u4G-1250000, ERDF
   100278533]; The synergetic university of TU Dresden [ZUK 64]
FX This project was financed from a fund belonging to the subproject 4G
   which is part of the state excellence initiative for realization of the
   future project ZUK 64 "The synergetic university of TU Dresden" and the
   European Regional Development Fund (F-003661-553u4G-1250000; ERDF
   100278533) .
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NR 25
TC 5
Z9 6
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD MAR
PY 2022
VL 140
AR 104301
DI 10.1016/j.mvr.2021.104301
EA JAN 2022
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA YJ6NX
UT WOS:000744649500003
PM 34971695
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Luo, BJ
   Zhang, HQ
   Zhong, JD
   He, XZ
   Shen, F
   Zheng, MC
   Wen, YS
   Li, JB
   Xin, MZ
AF Luo, Bao-Jia
   Zhang, Hui-Qin
   Zhong, Jiu-Di
   He, Xiang-Zi
   Shen, Fang
   Zheng, Mei-Chun
   Wen, Yong-Shan
   Li, Jin-Bo
   Xin, Ming-Zhu
TI A randomized trial of negative pressure wound therapy technology
   combined with intermittent instillation in the treatment of neck
   anastomotic leakage after esophageal cancer surgery
SO JOURNAL OF GASTROINTESTINAL ONCOLOGY
LA English
DT Article
DE Neck anastomotic fistula; negative pressure wound therapy combined with
   intermittent instillation; nursing
AB Background: This study aimed to examine the effects of applying the negative pressure wound therapy (NPWT) combined with intermittent instillation (NPWTi) in patients with cervical anastomotic leakage (AL) after esophageal cancer surgery.
   Methods: From July 2019 to June 2021, 64 patients undergoing AL after esophageal cancer surgery were selected from our Hospital's Thoracic Department, and randomly allocated to the conventional nursing group (20 patients), the hospital central NPWTi group (23 patients), and the portable NPWTi group (21 patients). The hospital central NPWTi group was treated with central negative pressure combined with intermittent instillation, and the portable NPWTi group was treated with portable negative pressure combined with intermittent instillation. Indicators of fistula healing, healing days, treatment costs, comfort, and nursing satisfaction were examined in each group.
   Results: The fistula healing rate, healing days, nursing satisfaction, and comfort level of the hospital central NPWTi group and the portable NPWTi group were better than those of the conventional nursing group (P<0.05). There was no difference in the fistula healing rates and healing days between the hospital central NPWTi group, and the portable NPWTi group (P>0.05). The treatment costs of the hospital central NPWTi group were lower than those of the portable NPWTi group (P<0.05).
   Conclusions: Negative pressure treatment technology combined with the intermittent instillation of the neck anastomotic fistula improved the fistula microenvironment, strengthened the sterilization effect, drained the leachate effectively, shortened the fistula healing time, improved the fistula cure rate, and increased patients' satisfaction with nursing. In relation to the negative pressure source, there was no difference in the therapeutic effects of hospital central NPWTi compared to the portable negative pressure meter, but the hospital central NPWTi treatment costs were lower and patients' acceptance of NPWT instillation was higher. "Thus, central NPWT instillation treatment is worthy of promotion.
C1 [Luo, Bao-Jia; Zhang, Hui-Qin; Zheng, Mei-Chun; Wen, Yong-Shan] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Colorectal Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [Zhong, Jiu-Di; Li, Jin-Bo] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Thorac Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [He, Xiang-Zi] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Tradit Chinese Med & VIP Reg, Guangzhou, Peoples R China.
   [Shen, Fang] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Gastr Surg Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [Xin, Ming-Zhu] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Nursing Dept, State Key Lab Oncol South China, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; State Key Lab Oncology South China; State Key
   Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen
   University; State Key Lab Oncology South China; Sun Yat Sen University;
   State Key Lab Oncology South China; Sun Yat Sen University; State Key
   Lab Oncology South China
RP Xin, MZ (通讯作者)，Sun Yat Sen Univ Canc Ctr, 651 Dong Feng Rd East, Guangzhou, Peoples R China.
EM xinmzh@sysucc.org.cn
RI Li, Jinbo/AAF-1566-2019
FU Guangdong Provincial Medical, Science and Technology Research Project
   [A2019239]
FX We received funding from the Guangdong Provincial Medical, Science and
   Technology Research Project 2019 (A2019239).
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NR 28
TC 4
Z9 4
U1 0
U2 16
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2078-6891
EI 2219-679X
J9 J GASTROINTEST ONCOL
JI J. Gastrointest. Oncol.
PD DEC
PY 2021
VL 12
IS 6
BP 2665
EP 2674
DI 10.21037/jgo-21-605
EA NOV 2021
PG 10
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA YT9CM
UT WOS:000734912000001
PM 35070396
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Serena, TE
   King, E
   Serena, L
   Breisinger, K
   Al-Jalodi, O
   Myntti, MF
AF Serena, Thomas E.
   King, Emily
   Serena, Laura
   Breisinger, Kristy
   Al-Jalodi, Omar
   Myntti, Matthew F.
TI A Diagnostic-Driven Prospective Clinical Study Evaluating the
   Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy
SO DIAGNOSTICS
LA English
DT Article
DE pressure ulcers; biofilm; negative pressure wound therapy; pressure
   injuries; fluorescence imaging; wound healing
ID ULCERS; INSTILLATION; BIOFILMS
AB Background: Each year, millions of Americans develop truncal pressure ulcers (PUs) which can persist for months, years, or until the end of life. Despite the negative impact on quality of life and escalating costs associated with PUs, there is sparse evidence supporting validated and efficacious treatment options. As a result, treatment is based on opinion and extrapolation from other wound etiologies. The ideal reconstructive plan maximizes the patient's nutritional status, incorporates the basic tenets of wound bed preparation (debridement, offloading, proper moisture balance, reduction of bacterial burden), and employs diagnostics to guide therapeutic intervention. The use of combination therapies can potentially overcome several of the barriers to wound healing. Negative pressure wound therapy (NPWT), a commonly used modality in the management of PUs, facilitates healing by stimulating the formation of granulation tissue and promoting wound contraction; however, NPWT alone is not always effective. Clinical studies examining microbial bioburden in PUs determined that most ulcers contain bacteria at levels that impede wound healing (>10(4) CFU/g). Objective: Thus, we hypothesized that adding an anti-microbial agent to decrease both planktonic and biofilm bacteria in the wound would increase the efficacy of NPWT. Method: In this prospective study, twenty patients with recalcitrant PUs that previously failed NPWT were treated with a biofilm-disrupting agent (Blast-X, Next Science, Jacksonville, FL, USA) in combination with NPWT. Fluorescence imaging was used to follow bacterial burden and guide therapy. Results: In total, 45% of the PUs reduced in size over the course of the four-week study, with a resolution of bacterial fluorescence in the NPWT dressing and wound bed seen in an average of three weeks. Conclusion: The combination of an antibiofilm agent and NPWT reduced bacterial levels and improved wound healing in recalcitrant PUs.
C1 [Serena, Thomas E.; King, Emily; Serena, Laura; Breisinger, Kristy; Al-Jalodi, Omar] SerenaGroup Res Fdn, Cambridge, MA 02140 USA.
   [Myntti, Matthew F.] Next Sci LLC, Jacksonville, FL 32256 USA.
RP King, E (通讯作者)，SerenaGroup Res Fdn, Cambridge, MA 02140 USA.
EM eking@serenagroups.com; lserena@serenagroups.com;
   kbreisinger@serenagroups.com; omarhjalodi@gmail.com;
   mmyntti@nextscience.org
OI AL-JALODI, OMAR/0000-0003-3725-3784; Serena, Thomas/0000-0003-1032-3578
FU Next Science
FX No Statement Available
CR Ammons MCB, 2011, INT WOUND J, V8, P268, DOI 10.1111/j.1742-481X.2011.00781.x
   Andersen C.A., 2023, J. Wound Manag, V24, P80
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NR 27
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR
PY 2024
VL 14
IS 7
AR 774
DI 10.3390/diagnostics14070774
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NP4Z8
UT WOS:001201656000001
PM 38611687
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Rafaqat, W
   Zamudio, JAP
   Abiad, M
   Lagazzi, E
   Argandykov, D
   Luckhurst, CM
   Velmahos, GC
   DeWane, MP
   Kaafarani, HMA
   Hwabejire, JO
AF Rafaqat, Wardah
   Zamudio, Jefferson A. Proano
   Abiad, May
   Lagazzi, Emanuele
   Argandykov, Dias
   Luckhurst, Casey M.
   Velmahos, George C.
   DeWane, Michael P.
   Kaafarani, Haytham M. A.
   Hwabejire, John O.
TI Negative pressure wound therapy for emergency laparotomy incisions: A
   national database propensity matched study
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; NPWT; Emergency; Laparotomy
ID SURGICAL SITE INFECTION; PREVENTION; CLOSURE
AB Background: Surgical site infections (SSI) are a common complication of laparotomy incisions. The role of Negative Pressure Wound Therapy (NPWT) in preventing SSIs has not yet been explored in a nationwide analysis. We aimed to evaluate the association of the prophylactic use of NPWT with SSIs in patients undergoing an emergency laparotomy procedure. Methods: We conducted a retrospective cohort study using the National Surgery Quality Initiative Program (NSQIP) database from 2013 to 2020. We included patients >= 18 years undergoing an emergency laparotomy. We performed a 1:1 propensity matching adjusting for patient age, sex, race, ethnicity, BMI, comorbid conditions, ASA status, diagnosis, preoperative factors and laboratory variables, procedure type, wound class, and intraoperative variables. We compared NPWT with standard dressings in two patient populations: 1. patients with completely closed (skin and fascia) laparotomy incisions and 2. patients with partially closed (fascia only) laparotomy incisions. Our primary outcome was the rate of incisional SSI. Secondary outcomes included the type of SSI, postoperative 30-day complications, postoperative hospital length of stay, and discharge disposition. Results: We included 65,803 patients with completely closed incisions of whom 387 patients received NPWT. There was no significant difference in the rate of total SSIs (13.4 % vs. 11.9 %; p = 0.52) in the matched population of 387 pairs. We included 7285 patients with partially closed incisions of whom 477 patients received NPWT. There was no significant difference in the rate of total SSIs (3.6 % vs. 4.4 %; p = 0.51) in the matched population of 477 pairs. Secondary outcomes did not differ significantly in either group. Conclusion: The rate of SSIs was not significantly different when prophylactic NPWT was used compared to standard dressings for patients with a closed or partially closed laparotomy incision.
C1 [Rafaqat, Wardah; Zamudio, Jefferson A. Proano; Abiad, May; Lagazzi, Emanuele; Argandykov, Dias; Luckhurst, Casey M.; Velmahos, George C.; DeWane, Michael P.; Kaafarani, Haytham M. A.; Hwabejire, John O.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Div Trauma Emergency Gen Surg & Surg Crit Care, Boston, MA USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Hwabejire, JO (通讯作者)，Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, 165 Cambridge St Suite 810, Boston, MA 02114 USA.
EM jhwabejire@mgb.org
RI Lagazzi, Emanuele/MDT-4749-2025; DeWane, Michael/JFB-6828-2023
OI Lagazzi, Emanuele/0000-0002-5696-9641; Hwabejire,
   John/0000-0003-0759-2638; Abiad, May/0000-0002-2257-7519; DeWane,
   Michael/0000-0002-7042-7400
CR Almansa-Saura S, 2021, SURG INFECT, V22, P854, DOI 10.1089/sur.2020.407
   American College of Surgeons, 2018, User guide for the 2017 ACS NSQIP participant use data file (PUF)
   American College of Surgeons, 2017, ACS NSQIP participant use data file
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   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
   CDC Ncezid DHQP, 2022, Surgical site infection event (SSI)
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   Javed AA, 2019, ANN SURG, V269, P1034, DOI 10.1097/SLA.0000000000003056
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NR 23
TC 3
Z9 3
U1 0
U2 1
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD FEB
PY 2024
VL 228
BP 287
EP 294
DI 10.1016/j.amjsurg.2023.10.055
EA FEB 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NA7A7
UT WOS:001197771100001
PM 37981515
DA 2026-07-24
ER

PT J
AU Zhu, Y
   Dai, LY
   Luo, BJ
   Zhang, L
AF Zhu, Yi
   Dai, Lingyan
   Luo, Binjie
   Zhang, Lin
TI Meta-analysis of prophylactic negative pressure wound therapy for
   surgical site infections (SSI) in caesarean section surgery
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE negative pressure wound therapy; surgical site infections; caesarean
   section; surgical dressings
ID RISK-FACTORS; OBESE WOMEN; COMPLICATIONS; DELIVERY; TRIAL
AB Introduction: Negative pressure wound therapy (NPWT) has been used in reducing the incidence of surgical site infections (SSIs) and wound complications across various surgical categories. SSIs are a common post-surgical com-plication following caesarean section (CS) births, making it necessary to use prophylactic interventions to reduce SSI and wound complication incidences.Aim: To conduct an updated meta-analysis on randomized controlled trials (RCTs) comparing SSI incidence and wound complications in women undergoing C-sections receiving NPWT or standard dressings after wound closure.Material and methods: A systematic literature review was conducted using MEDLINE and CENTRAL databases, and clinical trial registries for RCTs that involved NPWT versus standard dressings in participants undergoing C-section procedures. The primary outcome was surgical site infection (SSI) and other wound complications (haematoma, dehiscence, seroma.Results: A total of 11 RCTs were included in the meta-analysis with information from 5,693 patients. A reduction in overall SSI incidence (RR = 0.79, 95% CI: 0.66-0.95, p = 0.01, I2 = 0%) and wound complication rate (RR = 0.86, 0.75 to 0.98, p = 0.02, I2 = 5%) was found with all studies pooled together. Subgroup analyses showed that NPWT did not significantly reduce SSI incidence when stratified by the type of C-section (emergency/elective) whereas the type of NPWT device had a differential effect on SSI reduction, with PICO NPWT systems showing a beneficial effect (RR = 0.72, 0.58 to 0.91, p = 0.006, I2 = 0%) in comparison to the PREVENA closed-incision device (RR = 0.94, 0.68 to 1.29, p = 0.73, I2 = 0%).Conclusions: Prophylactic NPWT is useful in reducing the incidence of SSIs in women undergoing C-sections based on synthesis of results from RCTs in obese women (BMI > 30 kg/m2).
C1 [Zhu, Yi; Luo, Binjie] Nanjing Med Univ, Taizhou Sch Clin Med, Dept Burn Plast Surg, Taizhou City, Jiangsu, Peoples R China.
   [Dai, Lingyan] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Ambulatory Surg Ctr, Wuhan, Hubei, Peoples R China.
   [Zhang, Lin] First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
   [Zhang, Lin] First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
C3 Nanjing Medical University; Huazhong University of Science & Technology
RP Zhang, L (通讯作者)，First Peoples Hosp Jiangxia Dist, Dept Emergency, Wuhan 430200, Hubei, Peoples R China.
EM zhanglin190209@sina.com
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   Stitely M, CLIN GOV
   Tuuli MG, 2020, JAMA-J AM MED ASSOC, V324, P1180, DOI 10.1001/jama.2020.13361
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NR 34
TC 5
Z9 5
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2023
VL 18
IS 2
BP 224
EP 234
DI 10.5114/wiitm.2023.125913
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA L7HI5
UT WOS:001024928700004
PM 37680737
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Baharestani, MM
   Houliston-Otto, DB
   Barnes, S
AF Baharestani, Mona M.
   Houliston-Otto, Deborah B.
   Barnes, Sunni
TI Early Versus Late Initiation of Negative Pressure Wound Therapy:
   Examining the Impact on Home Care Length of Stay
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; pressure ulcer; home care; surgical
   wound
AB Because of the high cost of some wound management regimens, payors may require that moist wound therapies be used before other treatment approaches, such as negative pressure wound therapy (NPWT), are implemented but few studies have investigated the effect of delayed initiation of NPWT on patient outcomes. To examine the impact of early versus late initiation of NPWT on patient length of stay in home health care, a nonrandomized, retrospective analysis was performed on the Outcome and Assessment Information Set (OASIS) information for home care patients with NPWT-treated Stage III or Stage IV pressure ulcers (N = 98) or surgical wounds (N = 464) gathered between July 2002 and September 2004. Early initiation of NPWT following the start of home care was defined as < 30 days for pressure ulcers and < 7 days for surgical wound patients. Median duration of NPWT was 31 days (range 3 to 169) for pressure ulcers and 27 days (range 5 to 119) for the surgical wound group. Median lengths of stay in the early treatment groups were 85 days (range 11 to 239) for pressure ulcers and 57 days (range 7 to 119) for the surgical group versus 166 days (range 60 to 657) and 87 days (range 31 to 328), respectively, for the late treatment pressure ulcer and surgical groups (P < 0.0001). After controlling demographic patient variables, regression analysis indicated that for each day NPWT initiation was delayed, almost 1 day was added to the total length of stay (beta = 0.96, P < 0.0001 [pressure ulcers]; P = 0.97, P < 0.0001 [surgical wounds]). Early initiation of NPWT may be associated with shorter length of stay for patients receiving home care for Stage III or Stage IV pressure ulcers or surgical wounds. Additional studies to ascertain the cost-effectiveness of treatments and treatment approaches in home care patients are needed.
C1 [Baharestani, Mona M.] E Tennessee State Univ, Ctr Nursing Res, Off 1 112, Johnson City, TN 37614 USA.
   [Baharestani, Mona M.] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
C3 East Tennessee State University
RP Baharestani, MM (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Off 1 112, Roy Nicks Hall, Johnson City, TN 37614 USA.
EM Baharest@etsu.edu
CR [Anonymous], 2006, Licensed social workers in health, 2004, P1
   [Anonymous], FED REG
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NR 13
TC 19
Z9 19
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD NOV
PY 2008
VL 54
IS 11
BP 48
EP 53
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 381CF
UT WOS:000261511800009
PM 19037137
DA 2026-07-24
ER

PT J
AU Wu, LJ
   Guan, HL
   Yan, J
   Zhang, HY
   Fang, Q
   Wen, BY
   Lin, KF
   Xu, ZR
AF Wu, Lijiao
   Guan, Hongling
   Yan, Jin
   Zhang, Hongyan
   Fang, Qiong
   Wen, Baoyu
   Lin, Kefeng
   Xu, Zhaorong
TI An integrated medical-care wound management strategy in patients with
   hard-to-heal lower extremity ulcers undergoing negative pressure wound
   therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; hard-to-heal; negative pressure wound therapy; nursing;
   physicians; ulcers; wound; wound care; wound dressing; wound healing;
   wound healing; lower extremity ulcer; lower extremity ulcer; lower
   extremity ulcer; negative pressure wound therapy; nursing; physicians;
   ulcers; wound; wound care; wound dressing; wound healing
ID NURSE-PHYSICIAN COLLABORATION; COMMUNICATION; PERCEPTIONS
AB Objective: To explore the clinical effect of an integrated medical-care wound management strategy in nursing care for patients undergoing negative pressure wound therapy (NPWT) for hard-to-heal (chronic) lower extremity ulcers. Method: Patients admitted to Fujian Provincial Hospital, China, from January to December 2022 were assigned to either an experimental group or a control group. Patients in the experimental group received nursing care under the guidance of an integrated medical care wound management strategy, while patients in the control group received clinical primary nursing care. The differences between the two groups before and after NPWT with regards to wound condition, hospital length of stay (LoS), inflammation, pain, quality of life (QoL) and anxiety were analysed. Results: A total of 60 patients were included (30 in each group). Both groups showed wound contraction. The experimental group had significantly shorter wound healing times and LoS. Inflammation (measured by white blood cell counts and C-reactive protein levels) was reduced and pain was relieved in both groups. Physical function, role-physical, bodily pain, general health, vitality, mental health and anxiety after NPWT treatment were improved in both groups, while there were no significant differences in social functioning and roleemotional. The experimental group had significantly lower pain (as measured by numerical rating scale scores) and significantly better physical function, general health and mental health, and less bodily pain and anxiety than the control group, with statistically significant differences (p<0.05). Conclusion: The findings of this study showed that an integrated medical care wound management strategy for patients undergoing NPWT effectively promoted wound healing, reduced inflammation, alleviated pain, and improved the QoL of patients with hard-to-heal lower extremity ulcers, and deserves further research and promotion.
C1 [Wu, Lijiao; Guan, Hongling; Yan, Jin; Zhang, Hongyan; Fang, Qiong; Wen, Baoyu; Lin, Kefeng] Fujian Prov Hosp, Dept Orthoped Surg, South Branch, Fuzhou 350001, Peoples R China.
   [Wu, Lijiao; Guan, Hongling; Yan, Jin; Zhang, Hongyan; Fang, Qiong; Wen, Baoyu; Lin, Kefeng] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.
   [Xu, Zhaorong] Fujian Med Univ, Union Hosp, Burn & Wound Repair Dept, Fuzhou 350001, Peoples R China.
   [Xu, Zhaorong] Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Fujian, Peoples R China.
C3 Fujian Provincial Hospital; Fujian Medical University; Fujian Medical
   University; Fujian Medical University
RP Lin, KF (通讯作者)，Fujian Prov Hosp, Dept Orthoped Surg, South Branch, Fuzhou 350001, Peoples R China.; Lin, KF (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Union Hosp, Burn & Wound Repair Dept, Fuzhou 350001, Peoples R China.; Xu, ZR (通讯作者)，Fujian Med Univ, Fujian Prov Key Lab Burn & Trauma, Union Hosp, Fuzhou 350001, Fujian, Peoples R China.
EM kefenglin@foxmail.com; 234828306@qq.com
FU Fujian Provincial Key Laboratory of Burn and Trauma, China
FX This work was supported by the Fujian Provincial Key Laboratory of Burn
   and Trauma, China.
CR [Anonymous], 2010, Nursing's social policy statement: The essence of the profession, V3rd
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NR 27
TC 0
Z9 0
U1 3
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2025
VL 34
SU 8
BP xiii
EP xxi
DI 10.12968/jowc.2023.0148
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6GL2L
UT WOS:001552761500001
PM 40810935
DA 2026-07-24
ER

PT J
AU Wang, TK
   Chen, CH
   Chiu, WK
   Ni, CH
   Wang, CY
   Chen, KH
   Chen, CH
AF Wang, Ting-Kuang
   Chen, Chien-Hsin
   Chiu, Wen-Kuan
   Ni, Cheng-Hua
   Wang, Chin-Yun
   Chen, Kee-Hsin
   Chen, Chiehfeng
TI Negative pressure wound therapy for colorectal incisions: a systematic
   review and meta-analysis of controlled trials
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE colorectal surgery; meta-analysis; negative pressure wound therapy;
   surgical incision; surgical site infection; systematic review; wound;
   wound care; wound dressing; wound healing
ID SURGICAL SITE INFECTION; PREVENTION; LAPAROTOMY; CLOSURE
AB Objective: Negative pressure wound therapy (NPWT) has demonstrated promising results in reducing surgical site infection (SSI) rates following orthopaedic, vascular, cardiothoracic, plastic and abdominal surgery. The literature on use of NPWT on colorectal incisions is growing, with several randomised controlled trials (RCTs); however, findings have been inconsistent. This review evaluated the effectiveness and safety of NPWT for colorectal incisions in elective and emergency surgery. Method: The Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, and ClinicalTrials.gov databases were searched for RCTs and non-RCTs comparing NPWT with standard of care. Results: A total of five RCTs and six non-RCTs were included (with a total number of patients 2193). NPWT significantly reduced the rate of infection in colorectal incisions (odds ratio (OR): 0.57; 95% confidence interval (CI): 0.41, 0.78; I-2=14%; p<0.0005) and wound complications of the colorectal surgical incisions (OR: 0.33; 95% CI: 0.13, 0.88; I-2=59%; p=0.03). NPWT also shortened the wound healing time by three days (mean difference: -2.98; 95% CI: -4.99, -0.97; I-2=0%; p=0.004). Subgroup analysis revealed that NPWT conferred greater benefits on wounds resulting from life-threatening emergency surgery, and contaminated or dirty-infected wounds. Conclusion: The findings of this review showed that NPWT is an effective intervention for the closure of wounds in patients following colorectal surgery, and lead to a significant reduction in SSIs, overall wound complications, and mean complete wound healing time. It was particularly effective in emergency cases and in contaminated to dirty-infected wounds. Treatment options should be considered in terms of cost-benefits and adequate patient selection during shared decision-making.
C1 [Wang, Ting-Kuang; Ni, Cheng-Hua; Wang, Chin-Yun; Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applica, Taipei, Taiwan.
   [Wang, Ting-Kuang; Ni, Cheng-Hua; Wang, Chin-Yun; Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.
   [Wang, Ting-Kuang; Chen, Chien-Hsin] Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Colorectal Surg, Taipei, Taiwan.
   [Wang, Ting-Kuang] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
   [Chen, Chien-Hsin; Chiu, Wen-Kuan] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, Taipei, Taiwan.
   [Chiu, Wen-Kuan; Chen, Chiehfeng] Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Plast Surg, Taipei, Taiwan.
   [Ni, Cheng-Hua] Taipei Med Univ, Coll Nursing, Sch Nursing, Taipei, Taiwan.
   [Chen, Kee-Hsin] Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing, Taipei, Taiwan.
   [Chen, Kee-Hsin; Chen, Chiehfeng] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
   [Chen, Kee-Hsin] Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Wan Fang Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei, Taiwan.
C3 Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Municipal WanFang Hospital; Taipei Municipal WanFang Hospital; Taipei
   Medical University; Taipei Medical University
RP Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applica, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Dept Nursing, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Dept Surg, Div Plast Surg, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Coll Nursing, Postbaccalaureate Program Nursing, Taipei, Taiwan.; Chen, KH; Chen, CH (通讯作者)，Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.; Chen, KH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Evidence Based Knowledge Translat Ctr, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Wan Fang Hosp, Evidence Based Med Ctr, Taipei, Taiwan.; Chen, CH (通讯作者)，Taipei Med Univ, Coll Med, Sch Med, Dept Publ Hlth, Taipei, Taiwan.
EM keehsin@tmu.edu.tw; clifchen@tmu.edu.tw
RI Chen, Chien/QOA-7803-2026; Chen, Kee-Hsin/W-3576-2019
OI Chen, Kee-Hsin/0000-0001-9772-482X
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NR 55
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2025
VL 34
IS 7
BP 526
EP 537
DI 10.12968/jowc.2022.0219
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4ZK9P
UT WOS:001530327700001
PM 40632066
DA 2026-07-24
ER

PT J
AU Su, JW
   Zhang, D
   Du, JC
   Xiao, RZ
   Liu, Z
   Li, YQ
   Zhou, HW
   Li, J
AF Su, Junwei
   Zhang, Dong
   Du, Jincheng
   Xiao, Ruozu
   Liu, Zhe
   Li, Yuqian
   Zhou, Haowei
   Li, Jing
TI The Efficacy of Negative Pressure Wound Therapy Combined with Topical
   Oxygen Therapy in Treating Chronic Refractory Wounds: A Systematic
   Review and Meta-Analysis
SO ADVANCES IN WOUND CARE
LA English
DT Review; Early Access
DE combined therapy; negative pressure wound therapy; topical oxygen
   therapy; chronic refractory wounds; meta-analysis
ID TISSUE OXYGENATION; RICH
AB Objective: To evaluate the clinical efficacy of negative pressure wound therapy (NPWT) combined with topical oxygen therapy (TOT) for chronic refractory wounds (CRWs), addressing potential hypoxia limitation of NPWT through oxygen supplementation, thereby offering an innovative therapeutic approach for CRWs. <br /> Approach: The study was performed according to the 2015 Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. A comprehensive search was conducted in PubMed, Cochrane, Embase, Web of Science, CNKI, VIP, and Wanfang databases for randomized controlled trials (RCTs) on the treatment of CRWs with NPWT combined with TOT (inception to October 2024). Studies were screened based on predefined criteria, and data were extracted and assessed using RevMan 5.4. Meta-analysis, sensitivity analysis, and publication bias assessment were performed using Stata 15.0. <br /> Results: Eleven RCTs (844 patients) were included. Compared with NPWT, the combination therapy was associated with the following outcomes: increased healing rate (risk ratio [RR] = 1.51, 95% confidence interval [CI]: 1.36-1.69, I-2 = 18.1%), reduced time from debridement to skin grafting (mean difference [MD] = -2.82 days, 95% CI: -3.15 to -2.50, I-2 = 4%), shortened healing time (MD = -9.09 days, 95% CI: -11.98 to -6.20, I-2 = 91.2%), enhanced granulation coverage (MD = 7.56%, 95% CI: 6.09-9.03, I-2 = 0.0%), and decreased bacterial positivity (RR = 0.27, 95% CI: 0.18-0.41, I-2 = 0.0%). <br /> Innovation: This study provides evidence-based medical research supporting NPWT plus TOT as a synergistic strategy for CRWs. <br /> Conclusion: Combined therapy may offer benefits over NPWT alone in CRW treatment, suggesting a promising approach to improve healing outcomes.
C1 [Su, Junwei; Zhang, Dong; Du, Jincheng; Xiao, Ruozu; Liu, Zhe; Li, Yuqian; Zhou, Haowei; Li, Jing] Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, Xian, Peoples R China.
C3 Air Force Medical University
RP Zhou, HW; Li, J (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Burn & Plast Surg, Xian, Peoples R China.
EM zhw1213133955@126.com; jingle2015@163.com
RI Su, Junwei/ACU-7152-2022
FU Key Industrial Innovation Chain Project of Shaanxi Provincial Key
   Research and Development Plan Project [2022ZDLSF04-03]; Clinical Project
   at the Fourth Military Medical University [2024LC2420]
FX This work was supported by Key Industrial Innovation Chain Project of
   Shaanxi Provincial Key Research and Development Plan Project (No.
   2022ZDLSF04-03) and Clinical Project at the Fourth Military Medical
   University (No. 2024LC2420).
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NR 39
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD 2025 AUG 13
PY 2025
DI 10.1177/21621918251366606
EA AUG 2025
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6BE4R
UT WOS:001549189900001
PM 40796343
DA 2026-07-24
ER

PT J
AU Shirakawa, C
   Sakamoto, Y
   Ueki, S
   Shomura, H
   Kazui, K
   Taketomi, A
AF Shirakawa, Chisato
   Sakamoto, Yuzuru
   Ueki, Shinya
   Shomura, Hiroki
   Kazui, Keizo
   Taketomi, Akinobu
TI Usefulness of a negative pressure wound therapy system for stoma closure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hospital stay; negative pressure wound therapy; PICO; postoperative
   pain; purse-string closure; stoma; surgical site infection; wound; wound
   care; wound dressing; wound healing
ID ILEOSTOMY
AB Objective: Although wound infection rates after stoma closure have decreased, they remain high. Negative pressure wound therapy (NPWT) for stoma closure wounds can shorten healing time for many wound types. The PICO (Smith+Nephew, UK) wound dressing, a single-use NPWT system that can be used for outpatients, was introduced at the Japan Community Health Care Organization Hokkaido Hospital, Japan in November 2017. We evaluated the effectiveness of this dressing in stoma closure wounds. Method: We retrospectively evaluated patients who underwent stoma closure between March 2012 and July 2021. We compared postoperative short-term outcomes (surgical site infection (SSI), number of pain medications, and postoperative hospital stay) by allocating the patients to one of two groups: purse-string closure or purse-string closure with PICO. The purse-string closure group (PC) underwent purse-string closure alone, while the other group underwent purse-string closure and PICO (PCP). Results: A total of 35 patients were evaluated; 20 in the PC group and 15 in the PCP group. No significant differences in characteristics were noted between the groups. Comparisons between stoma closure techniques revealed that the PCP group had shorter hospital stays (p=0.04), lower SSI rates (p=0.04), and less pain medication (p<0.01) than the PC group. Comparisons between SSI occurrence revealed that the group of patients with an SSI had a higher number of colostomies compared with ileostomies (37.5% versus 0%, p<0.01, respectively), used more pain medication (p<0.01), and had longer hospital stays (p=0.04) than patients who did not have an SSI. Conclusion: After stoma closure, combining PICO with purse-string closure may be effective in preventing SSI and controlling postoperative pain. Declaration of interest: The authors have no conflicts of interest.
C1 [Shirakawa, Chisato; Sakamoto, Yuzuru; Ueki, Shinya; Shomura, Hiroki; Kazui, Keizo] Japan Community Hlth Care Org Hokkaido Hosp 8, Dept Gastroenterol Surg, 8-3-18 Nakanoshima 1 Jo,Toyohira Ku, Sapporo 0628618, Japan.
   [Sakamoto, Yuzuru] Wakkanai City Hosp 4, Dept Gastroenterol Surg, 4-11-6 Chuo, Wakkanai 0978555, Japan.
   [Taketomi, Akinobu] Hokkaido Univ, Fac Med, Grad Sch Med, Dept Gastroenterol Surg, Kita-15 Nishi-7,Kita Ku, Sapporo 0608638, Japan.
C3 Hokkaido University
RP Sakamoto, Y (通讯作者)，Japan Community Hlth Care Org Hokkaido Hosp 8, Dept Gastroenterol Surg, 8-3-18 Nakanoshima 1 Jo,Toyohira Ku, Sapporo 0628618, Japan.; Sakamoto, Y (通讯作者)，Wakkanai City Hosp 4, Dept Gastroenterol Surg, 4-11-6 Chuo, Wakkanai 0978555, Japan.
EM yuzurusakamoto18@gmail.com
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NR 20
TC 2
Z9 2
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2025
VL 34
IS 2
BP 106
EP 110
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1PF7G
UT WOS:001470389200002
PM 39928473
DA 2026-07-24
ER

PT J
AU McMillan, H
   Vo, UG
   Moss, JL
   Barry, IP
   Bosanquet, DC
   Richards, T
AF McMillan, Hayley
   Vo, Uyen G.
   Moss, Jana-Lee
   Barry, Ian P.
   Bosanquet, David C.
   Richards, Toby
TI Controlling the controls: what is negative pressure wound therapy
   compared to in clinical trials?
SO COLORECTAL DISEASE
LA English
DT Article
DE control dressing; negative pressure wound therapy; standard of care;
   surgical site infection
ID SURGICAL SITE INFECTION; CESAREAN DELIVERY; PRIMARY HIP; COMPLICATIONS;
   RISK; DRESSINGS; SURGERY; ARTHROPLASTY; METAANALYSIS; LAPAROTOMY
AB AimSurgical site infections (SSIs) are common following colorectal operations. Clinical trials suggest that closed incision negative pressure wound therapy (ciNPWT) may reduce SSIs compared to a 'standard of care' group. However, wound management in the standard of care group may vary. The aim of this review was to assess the control arms in trials of ciNPWT for potential confounding variables that could influence the rates of SSI and therefore the trial outcomes. MethodsA mapping review of the PubMed database was undertaken in the English language for randomized controlled trials that assessed, in closed surgical wounds, the use of ciNPWT compared to standard of care with SSI as an outcome. Data regarding wound care to assess potential confounding factors that may influence SSI rates were compared between the ciNPWT and standard of care groups. Included were the method of wound closure, control dressing type, frequency of dressing changes and postoperative wound care (washing). ResultsTwenty-seven trials were included in the mapping review. There was heterogeneity in ciNPWT duration. There was little control in the comparator standard of care groups with a variety of wound closure techniques and different control dressings used. Overall standard of care dressings were changed more frequently than the ciNPWT dressing and there was no control over wound care or washing. No standard for 'standard of care' was apparent. ConclusionIn randomized trials assessing the intervention of ciNPWT compared to standard of care there was considerable heterogeneity in the comparator groups and no standard of care was apparent. Heterogeneity in dressing protocols for standard of care groups could introduce potential confounders impacting SSI rates. There is a need to standardize care in ciNPWT trials to assess potential meaningful differences in SSI prevention.
C1 [McMillan, Hayley; Vo, Uyen G.; Moss, Jana-Lee; Richards, Toby] Univ Western Australia, Fiona Stanley Hosp, Div Surg, Perkins South Bldg, Perth, WA, Australia.
   [Vo, Uyen G.; Moss, Jana-Lee; Barry, Ian P.] Fiona Stanley Hosp, Dept Vasc Surg, Perth, WA, Australia.
   [Bosanquet, David C.] Royal Gwent Hosp, South East Wales Vasc Network, Newport, Gwent, Wales.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fiona Stanley Hospital; University of Western Australia; South
   Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group;
   Fiona Stanley Hospital; Royal Gwent Hospital
RP McMillan, H (通讯作者)，Univ Western Australia, Fiona Stanley Hosp, Div Surg, Perkins South Bldg, Perth, WA, Australia.
EM hayley.mcmillan@health.wa.gov.au
RI Richards, Toby/K-6547-2013; Bosanquet, David/AAB-1557-2022
OI Richards, Toby/0000-0001-9872-4653; Vo, Uyen Giao/0000-0002-6340-9263;
   McMillan, Hayley/0000-0003-2599-0699; Bosanquet,
   David/0000-0003-2304-0489
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NR 53
TC 0
Z9 0
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD APR
PY 2023
VL 25
IS 4
BP 794
EP 805
DI 10.1111/codi.16465
EA JAN 2023
PG 12
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA F1OX8
UT WOS:000919738900001
PM 36579358
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ashby, RL
   Dumville, JC
   Soares, MO
   McGinnis, E
   Stubbs, N
   Torgerson, DJ
   Cullum, N
AF Ashby, Rebecca L.
   Dumville, Jo C.
   Soares, Marta O.
   McGinnis, Elizabeth
   Stubbs, Nikki
   Torgerson, David J.
   Cullum, Nicky
TI A pilot randomised controlled trial of negative pressure wound therapy
   to treat grade III/IV pressure ulcers [ISRCTN69032034]
SO TRIALS
LA English
DT Article
DE Negative pressure wound therapy; Pressure ulcer; Pilot randomised
   controlled trial
ID VENOUS LEG ULCERS; QUALITY-OF-LIFE; CLINICAL-TRIAL; ULCERATION; COST; UK
AB Background: Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A trial of NPWT for the treatment of grade III/IV pressure ulcers would be worthwhile but premature without assessing whether such a trial is feasible. The aim of this pilot randomised controlled trial was to assess the feasibility of conducting a future full trial of NPWT for the treatment of grade III and IV pressure ulcers and to pilot all aspects of the trial.
   Methods: This was a two-centre (acute and community), pilot randomised controlled trial. Eligible participants were randomised to receive either NPWT or standard care (SC) (spun hydrocolloid, alginate or foam dressings). Outcome measures were time to healing of the reference pressure ulcer, recruitment rates, frequency of treatment visits, resources used and duration of follow-up.
   Results: Three hundred and twelve patients were screened for eligibility into this trial over a 12-month recruitment period and 12/312 participants (3.8%) were randomised: 6 to NPWT and 6 to SC. Only one reference pressure ulcer healed (NPWT group) during follow-up (time to healing 79 days). The mean number of treatment visits per week was 3.1 (NPWT) and 5.7 (SC); 6/6 NPWT and 1/6 SC participants withdrew from their allocated trial treatment. The mean duration of follow-up was 3.8 (NPWT) and 5.0 (SC) months.
   Conclusions: This pilot trial yielded vital information for the planning of a future full study including projected recruitment rate, required duration of follow-up and extent of research nurse support required. Data were also used to inform the cost-effectiveness and value of information analyses, which were conducted alongside the pilot trial.
C1 [Ashby, Rebecca L.; Dumville, Jo C.; Torgerson, David J.] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
   [Soares, Marta O.] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [McGinnis, Elizabeth] Leeds Gen Infirm, Leeds Teaching Hosp NHS Trust, Leeds, W Yorkshire, England.
   [Stubbs, Nikki] St Marys Hosp, NHS Leeds Community Healthcare, Leeds, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of York - UK; University of York - UK; Leeds General
   Infirmary; University of Leeds; University of Manchester
RP Cullum, N (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester, Lancs, England.
EM nicky.cullum@manchester.ac.uk
RI McGinnis, Elizabeth/PNF-2864-2026; Dumville, Jo/O-7867-2014; Torgerson,
   David/L-4566-2019; Cullum, Nicky/F-2438-2011; Soares, Marta Ferreira
   Oliveira/HJH-3434-2023
OI Dumville, Jo/0000-0002-6546-3685; Torgerson, David/0000-0002-1667-4275;
   Cullum, Nicky/0000-0003-2631-123X; Soares, Marta Ferreira
   Oliveira/0000-0003-1579-8513; McGinnis, Elizabeth/0000-0002-2848-9149
FU Medical Research Council [G0501814]; Medical Research Council [G0501814]
   Funding Source: researchfish; MRC [G0501814] Funding Source: UKRI
FX We would like to gratefully acknowledge the participants who took part
   in this research study. We would also like to thank Research Nurse Sally
   Blundell and the nurses in NHS Leeds who were responsible for data
   collection. Thanks are also due to Una Adderley who performed the
   blinded assessment of wound photographs. This work was supported by the
   Medical Research Council (grant no. G0501814).
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NR 43
TC 32
Z9 42
U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUL 28
PY 2012
VL 13
AR 119
DI 10.1186/1745-6215-13-119
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 065QD
UT WOS:000313162600001
PM 22839453
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ahn, J
   Flaherty, A
AF Ahn, Jiyong
   Flaherty, Alexandra
TI Utility of 3D Wound Assessment in Monitoring Granulation Tissue Velocity
   Following Negative-Pressure Wound Therapy in Diabetic Foot Ulcers
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE amputation; diabetic mellitus; diabetic foot; negative-pressure wound
   therapy; 3D wound assessment
ID AREA
AB Background: Wound healing in diabetic foot ulcers (DFUs) is challenging and often requires extensive debridement and in some cases leads to amputation. Negative-pressure wound therapy (NPWT) can be utilized for DFUs. The optimal time frame for successful NPWT lacks consensus. Advanced wound scanning with a three-dimensional (3D) camera can enhance accuracy of DFU area and volume calculations. This study aimed to investigate the utility of 3D wound assessment in monitoring granulation tissue filling velocity with NPWT in DFUs.Methods: A retrospective case series study was performed for 101 DFUs (Wagner classification 3 or 4 lesions with significant necrotic tissue debridement failing to achieve primary closure, leading to open amputation) undergoing NPWT from September 2018 to June 2019. Demographic data and wound characteristics were recorded. Before application of NPWT, wounds were irrigated after extensive procedures, and digital photographs of the wound were captured using an infrared 3D camera. Wound area and volume were measured weekly from before the application of NPWT to 1 month after. Risk factors associated with wound healing in DFUs were also evaluated.Results: NPWT resulted in significant area improvements for open DFUs. Postoperative 1-week area change velocity was 1.35 cm2/d, peaking at 2 weeks (1.84 cm2/d). Volume also showed significant improvement over time (P = .001), with a 1-week peak velocity of 1.20 cm3/d. All peak area and volume changes occurred within 2 weeks after NPWT application. Compared to the midfoot and hindfoot, the forefoot exhibited a lower velocity of volume (P = .001).Conclusion: 3D wound assessment for the velocity of granulation tissue filled in an open DFU after NPWT can be useful for monitoring healing progression. Most wound healing following NPWT in DFUs was completed within the first 2 weeks.
C1 [Ahn, Jiyong] Bumin Hosp Seoul, Dept Orthopaed Surg, 389 Gonghang Daero, Seoul 07590, South Korea.
   [Ahn, Jiyong; Flaherty, Alexandra] Harvard Med Sch, Massachusetts Gen Hosp MGH, Dept Orthopaed Surg, Foot & Ankle Res & Innovat Lab FARIL, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Ahn, J (通讯作者)，Bumin Hosp Seoul, Dept Orthopaed Surg, 389 Gonghang Daero, Seoul 07590, South Korea.
EM ilmon@hanmail.net
RI Ahn, Ji-Yong/KDN-0493-2024
OI Ahn, Ji-Yong/0000-0003-0309-2193
FU Department of Orthopaedic Surgery funded by Catholic University of Korea
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by a grant of the Department of Orthopaedic Surgery funded
   by Catholic University of Korea made in the program year of 2018.
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NR 25
TC 0
Z9 0
U1 4
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD MAR
PY 2025
VL 46
IS 3
BP 287
EP 294
DI 10.1177/10711007251314805
EA FEB 2025
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 0AM5C
UT WOS:001420820200001
PM 39950603
DA 2026-07-24
ER

PT J
AU Roberson, DS
   McLeay, MT II
   Henning, G
   Morales-Martinez, G
   Thapa, P
   Khanna, A
   Frank, I
   Tollefson, MK
   Shah, P
   Karnes, RJ
   Boorjian, SA
   Sharma, V
AF Roberson, Daniel S.
   McLeay II, Matthew T.
   Henning, Grant
   Morales-Martinez, Gianni
   Thapa, Prabin
   Khanna, Abhinav
   Frank, Igor
   Tollefson, Matthew K.
   Shah, Paras
   Karnes, R. Jeffrey
   Boorjian, Stephen A.
   Sharma, Vidit
TI The impact of prophylactic incisional negative pressure wound therapy on
   surgical site infection following open radical cystectomy
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Article
DE Negative pressure wound therapy; Surgical wound infection; Abdominal
   wound closure; Cystectomy; Bladder cancer
ID PREVENTION; LAPAROTOMY; MORBIDITY; TRIAL
AB Purpose: Surgical site infection (SSI) following open radical cystectomy (ORC) is common and carries significant morbidity. Incisional negative pressure wound therapy (iNPWT) has not been rigorously studied in this population. Herein, we evaluate the association between prophylactic iNPWT and postoperative wound complications in ORC patients. Materials and methods: We queried our institutional, prospectively maintained cystectomy registry for patients who underwent ORC between 2000 and 2023, and stratified patients by receipt of prophylactic iNPWT. The primary outcome was SSI incidence within 90-days following surgery. Secondary outcomes included 90-day wound dehiscence, symptomatic seroma, and a composite endpoint of any of those 3 wound events. Multivariable logistic regression models adjusted for patient characteristics. Results: Among 2,375 patients who underwent ORC, 124(5.2%) received prophylactic iNPWT. Patients who received iNPWT had higher rates of SSI risk factors: median BMI (31 vs. 28, P < 0.01), diabetes (28% vs. 18%, P = 0.01), and ileal conduit diversion (86% vs. 71%, P < 0.01). On unadjusted analyses, SSI incidence was 6.5% and 10.4% for the iNPWT and non-iNPWT cohorts, respectively. After adjusting for baseline characteristics, prophylactic iNPWT was associated with a significantly lower odds of SSI (OR 0.47, 95%CI 0.22-0.99, P = 0.048). No significant associations were observed between iNPWT utilization and secondary outcomes. Conclusions: Prophylactic iNPWT therapy is associated with a reduced risk of SSI following ORC. While prospective and randomized corroboration is warranted, these data support the incorporation of this low-cost intervention into postoperative pathways for high-risk ORC patients. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Roberson, Daniel S.; McLeay II, Matthew T.; Henning, Grant; Morales-Martinez, Gianni; Khanna, Abhinav; Frank, Igor; Tollefson, Matthew K.; Shah, Paras; Karnes, R. Jeffrey; Boorjian, Stephen A.; Sharma, Vidit] Mayo Clin, Dept Urol, Rochester, MN 55905 USA.
   [Thapa, Prabin] Mayo Clin, Dept Hlth Serv Res, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Roberson, DS (通讯作者)，Mayo Clin, Dept Urol, Rochester, MN 55905 USA.
EM Roberson.daniel@mayo.edu
RI ; Rader, Daniel/AFQ-9696-2022
OI Henning, Grant/0000-0003-4582-6685; 
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NR 17
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD OCT
PY 2025
VL 43
IS 10
BP 586
EP 593
DI 10.1016/j.urolonc.2025.07.010
EA JAN 2025
PG 8
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA 7JF6T
UT WOS:001572321900008
PM 40796397
DA 2026-07-24
ER

EF