﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Liu, X
   Zhang, H
   Cen, SQ
   Huang, FG
AF Liu, Xi
   Zhang, Hui
   Cen, Shiqiang
   Huang, Fuguo
TI Negative pressure wound therapy versus conventional wound dressings in
   treatment of open fractures: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Meta-analysis; The negative pressure wound therapy (NPWT); Open
   fracture; Infection; Flap; Wound healing
ID TEMPORARY TREATMENT; TRAUMATIC WOUNDS; INFECTION; VACUUM; MANAGEMENT;
   CLOSURE; NPWT
AB Background: Though several systematic reviews concerned have been published, controversy still exists. The current systematic review was designed to clarify the detailed advantages and disadvantages of the negative pressure wound therapy (NPWT) in treatment of open fractures in comparison with the conventional wound dressings.
   Methods: A systematic search was performed in Pubmed, Cochrane Library, Embase, and Google Scholar for the published relevant clinical studies. Unpublished studies were searched in Clinicaltrials, ICTRP and ISRCTN. The outcome measures included presence of infection, wound healing process, length of the patient hospital stay, flap issues, frequency of amputation, and patient life quality.
   Results: In the 8 randomized controlled trials (RCTs) (421 patients) and the 6 retrospective cohort studies (488 patients), NPWT resulted in a significantly lower infection rate, significantly shorter wound coverage time, wound healing time and hospital stay length, and the lower amputation rate. However, no statistically significant difference was found in the need for flap surgery, the proportion of free flaps, the flap failure rate or the fracture non-union rate. Only 1 RCT was reported to have a higher physical component score of short form 36 in the infected patients.
   Conclusion: NPWT can significantly reduce the risk of infection in treatment of open fractures and accelerate their wound healing process. Some but not much evidence suggests that NPWT may possibly help reduce the severity of the limb injury and therefore provide a chance for the limb to avoid amputation. Use of NPWT in the flap area is probably safe, but should be carried out with caution. The advantage of NPWT over the conventional wound dressings still requires to be confirmed in the other aspects.
C1 [Liu, Xi; Zhang, Hui; Cen, Shiqiang; Huang, Fuguo] Sichuan Univ, West China Hosp, Dept Orthopaed Surg, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University
RP Zhang, H (通讯作者)，Sichuan Univ, West China Hosp, Dept Orthopaed Surg, Chengdu, Sichuan, Peoples R China.
EM 13540638434@163.com; zhanghuiwestchina@163.com; Ahsir7201@126.com;
   Huang-f-g@163.com
RI Zhang, Hui/OTH-2486-2025
CR [Anonymous], THESIS AM SOC PLAST
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NR 34
TC 84
Z9 106
U1 3
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD MAY
PY 2018
VL 53
BP 72
EP 79
DI 10.1016/j.ijsu.2018.02.064
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GG4GN
UT WOS:000432654400012
PM 29555530
DA 2026-07-24
ER

PT J
AU Christodoulou, N
   Wolfe, B
   Mathes, DW
   Malgor, RD
   Kaoutzanis, C
AF Christodoulou, Neophytos
   Wolfe, Brandon
   Mathes, David W.
   Malgor, Rafael D.
   Kaoutzanis, Christodoulos
TI Vacuum-assisted closure therapy for the management of deep sternal wound
   complications: A systematic review and meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Vacuum-assisted closure; Deep sternal wound complications;
   Mediastinitis; Osteomyelitis; Sternal dehiscence
ID DIABETIC FOOT ULCERS; CARDIAC-SURGERY; SUCTION DRAINAGE; RISK-FACTORS;
   PRESSURE; INFECTION; MEDIASTINITIS; STERNOTOMY; MORTALITY;
   RECONSTRUCTION
AB stay and cost of treatment Background: Vacuum -assisted closure (VAC ) therapy has become a popular treatment option for wound healing. The aim of this meta -analysis was to assess the use of VAC therapy as a bridge before the definitive treatment for the management of deep sternal wound complications. Methods: A systematic literature review and meta -analysis were performed in PubMed and Embase. Outcomes of interest included mortality, treatment failure, length of hospital stay (LOS ), length of intensive care unit (ICU ) stay and cost of treatment. Results: Twenty -two studies involving 1980 patients were included in the quantitative synthesis of this meta -analysis. Patients treated with VAC had significantly lower overall mortality [1738 patients; Risk ratio [RR ] = 0.36 (95% confidence interval [CI ]: 0.25, 0.51 )], treatment failure [1210 patients; RR = 0.26 (95% CI: 0.19, 0.37 )], LOS [498 patients; (standard mean difference = -0.44 (95% CI: -0.81, -0.07 )] and ICU stay [309 patients; (standard mean difference = -0.34 (95% CI: -0.67, -0.01 )] compared to that of non -VAC patients. VAC therapy was associated with reduced cost of treatment per patient compared with that of non -VAC therapies (reductions of 3600 USD, 6000 USD and 8983 USD in the reported studies ). Conclusions: VAC therapy as an adjunct in the definitive treatment of patients with deep sternal wound complications was associated with lower mortality, treatment failure, LOS, ICU when compared with a non -VAC approach. Randomised controlled trials would be essential to confirm these findings. (c) 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Christodoulou, Neophytos] Royal Papworth Hosp, Papworth Rd, Cambridge, England.
   [Wolfe, Brandon] Univ Colorado Anschutz Med Campus, Sch Med, Aurora, CO USA.
   [Kaoutzanis, Christodoulos] Univ Colorado Anschutz Med Campus, Dept Surg, Div Plast & Reconstruct Surg, Aurora, CO USA.
   [Malgor, Rafael D.] Univ Colorado, Anschutz Med Ctr, Div Vasc Surg & Endovascular Therapy, Aurora, CO USA.
C3 Papworth Hospital; University of Colorado System; University of Colorado
   Anschutz; University of Colorado System; University of Colorado
   Anschutz; University of Colorado System; University of Colorado Anschutz
RP Kaoutzanis, C (通讯作者)，Acad Off AO1, 12631 East 17th Ave,Mail Stop C309, Aurora, CO 80045 USA.
EM ckaoutzanis@gmail.com
OI Christodoulou, Neophytos/0000-0002-5425-8686; Kaoutzanis,
   Christodoulos/0000-0002-5631-8355
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NR 52
TC 5
Z9 6
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JUL
PY 2024
VL 94
BP 251
EP 260
DI 10.1016/j.bjps.2023.09.049
EA JUN 2024
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WI3Z2
UT WOS:001254214300001
PM 37951723
DA 2026-07-24
ER

PT J
AU Takahara, S
   Sai, S
   Kagatani, T
   Konishi, A
AF Takahara, Shingo
   Sai, Sadahiro
   Kagatani, Tomoaki
   Konishi, Akinobu
TI Efficacy and haemodynamic effects of vacuum-assisted closure for
   post-sternotomy mediastinitis in children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Mediastinal infection; Vacuum-assisted closure; Congenital heart
   disease; Paediatrics; Circulatory haemodynamics
ID PEDIATRIC CARDIAC-SURGERY; POSTOPERATIVE MEDIASTINITIS; NEGATIVE
   PRESSURES; THERAPY; INFECTION; IRRIGATION; EXPERIENCE; SWINE
AB OBJECTIVES: Post-sternotomy mediastinitis is a significant morbidity with controversial management. Vacuum-assisted closure (VAC) has been used to treat mediastinitis, with many reports documenting its efficacy and feasibility, particularly in adults. However, its use is not prevalent in the paediatric population because of concerns that it may deteriorate haemodynamics. This study aimed to evaluate outcomes and effects of VAC on the haemodynamics of paediatric patients with post-sternotomy mediastinitis.
   METHODS: Six patients were treated with VAC between April 2005 and March 2013. We retrospectively investigated their profiles, clinical outcomes and haemodynamic changes, including mean blood pressure (MBP), mean heart rate (MHR), urinary output, amount of diuretics and vasoactive-inotropic score (VIS), before and after VAC initiation.
   RESULTS: The median age and body weight of patients were 6.4 months and 4.5 kg, respectively. Three patients (50%) had single ventricular physiology. The median VAC duration was 12 days. One patient died of pulmonary venous obstruction after mediastinitis was cured. The average MBPs in every 8-h period were examined, and there were no significant changes (P = 0.773); the average MHRs were examined in the same manner and they decreased significantly after initiation of VAC (P = 0.032). Only 2 patients required vasoactive agents. The VIS did not change in 1 patient and decreased in the other. The mean amount of diuretics administered and urinary output per body weight did not change significantly (P = 0.395 and 0.273, respectively).
   CONCLUSIONS: In conclusion, the haemodynamics of children were not significantly affected by the negative pressure of VAC, indicating that this therapy may be safe and effective for post-sternotomy mediastinitis, even in small children with complex cardiac anomalies.
C1 [Takahara, Shingo; Sai, Sadahiro; Kagatani, Tomoaki; Konishi, Akinobu] Miyagi Childrens Hosp, Dept Cardiovasc Surg, Aoba Ku, Sendai, Miyagi 9893126, Japan.
RP Takahara, S (通讯作者)，Miyagi Childrens Hosp, Dept Cardiovasc Surg, Aoba Ku, 4-3-17 Ochiai, Sendai, Miyagi 9893126, Japan.
EM dr_takashin@hotmail.com
RI Takahara, Shingo/AAZ-4640-2021
OI Takahara, Shingo/0000-0002-8363-293X
CR Anslot C, 2007, ANN THORAC SURG, V84, P423, DOI 10.1016/j.athoracsur.2007.03.064
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NR 22
TC 5
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD OCT
PY 2014
VL 19
IS 4
BP 627
EP 631
DI 10.1093/icvts/ivu234
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AR1CO
UT WOS:000343318800019
PM 25006212
DA 2026-07-24
ER

PT J
AU Bludau, M
   Fuchs, HF
   Herbold, T
   Maus, MKH
   Alakus, H
   Popp, F
   Leers, JM
   Bruns, CJ
   Hölscher, AH
   Schröder, W
   Chon, SH
AF Bludau, Marc
   Fuchs, Hans F.
   Herbold, Till
   Maus, Martin K. H.
   Alakus, Hakan
   Popp, Felix
   Leers, Jessica M.
   Bruns, Christiane J.
   Hoelscher, Arnulf H.
   Schroeder, Wolfgang
   Chon, Seung-Hun
TI Results of endoscopic vacuum-assisted closure device for treatment of
   upper GI leaks
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Society-of-American-Gastrointestinal-and-Endoscopic-Surgeons (SAGES)
CY MAR 22-25, 2017
CL Houston, TX
SP Soc Amer Gastrointestinal & Endoscop Surg
DE Esophageal perforation; Anastomotic leakage; Endoscopic vacuum-assisted
   closure system
ID ESOPHAGEAL-PERFORATION; RETROSPECTIVE ANALYSIS; ANASTOMOTIC LEAKAGE;
   TREATMENT OPTIONS; THERAPY; MANAGEMENT; STENT
AB Esophageal perforations and postoperative leakage of esophagogastrostomies are considered to be life-threatening conditions due to the potential development of mediastinitis and consecutive sepsis. Vacuum-assisted closure (VAC) techniques, a well-established treatment method for superficial infected wounds, are based on a negative pressure applied to the wound via a vacuum-sealed sponge. Endoluminal VAC (E-VAC) therapy as a treatment for GI leakages in the rectum was introduced in 2008. E-VAC therapy is a novel method, and experience regarding esophageal applications is limited. In this retrospective study, the experience of a high-volume center for upper GI surgery with E-VAC therapy in patients with leaks of the upper GI tract is summarized. To our knowledge, this series presents the largest patient cohort worldwide in a single-center study.
   Between October 2010 and January 2017, 77 patients with defects in the upper gastrointestinal tract were treated using the E-VAC application. Six patients had a spontaneous perforation, 12 patients an iatrogenic injury, and 59 patients a postoperative leakage in the upper gastrointestinal tract.
   Complete restoration of the esophageal defect was achieved in 60 of 77 patients. The average duration of application was 11.0 days, and a median of 2.75 E-VAC systems were used. For 21 of the 77 patients, E-VAC therapy was combined with the placement of self-expanding metal stents.
   This study demonstrates that E-VAC therapy provides an additional treatment option for esophageal wall defects. Esophageal defects and mediastinal abscesses can be treated with E-VAC therapy where endoscopic stenting may not be possible. A prospective multi-center study has to be directed to bring evidence to the superiority of E-VAC therapy for patients suffering from upper GI defects.
C1 [Bludau, Marc; Fuchs, Hans F.; Maus, Martin K. H.; Alakus, Hakan; Popp, Felix; Leers, Jessica M.; Bruns, Christiane J.; Schroeder, Wolfgang; Chon, Seung-Hun] Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
   [Herbold, Till] Rhein Westfal TH Aachen, Dept Gen Visceral & Canc Surg, Aachen, Germany.
   [Hoelscher, Arnulf H.] Agaples Markus Hosp, Dept Gen Thorac & Vasc Surg, Frankfurt, Germany.
C3 University of Cologne; RWTH Aachen University
RP Bludau, M (通讯作者)，Univ Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
EM Marc.Bludau@uk-koeln.de
RI Chon, Seung-Hun/PHE-1824-2026; Schröder, Wolfgang/A-8799-2008;
   /AAP-2598-2021
OI Bludau, Marc/0000-0002-0338-1545; Chon, Seung-Hun/0000-0002-8923-6428
CR Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
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   Schröder W, 2014, CHIRURG, V85, P1064, DOI 10.1007/s00104-014-2805-z
   Smallwood NR, 2016, SURG ENDOSC, V30, P2473, DOI 10.1007/s00464-015-4501-6
   Vallböhmer D, 2010, DIS ESOPHAGUS, V23, P185, DOI 10.1111/j.1442-2050.2009.01017.x
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NR 20
TC 108
Z9 123
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD APR
PY 2018
VL 32
IS 4
BP 1906
EP 1914
DI 10.1007/s00464-017-5883-4
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA FY9BD
UT WOS:000427159300035
PM 29218673
DA 2026-07-24
ER

PT J
AU Zhang, CW
   Liu, DL
   Liang, Z
   Liu, F
   Lin, HB
   Guo, ZD
AF Zhang, Chenwei
   Liu, Dalie
   Liang, Zhi
   Liu, Fei
   Lin, Haibo
   Guo, Zhengdong
TI Repair of Refractory Wounds Through Grafting of Artificial Dermis and
   Autologous Epidermis Aided by Vacuum-Assisted Closure
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE VAC; Artificial dermis; Wound; Autologous epidermis
ID NEGATIVE-PRESSURE THERAPY; TISSUE DEFECTS; RECONSTRUCTION; FOUNDATION;
   DRESSINGS; INTEGRA; STATE; SOFT
AB This study aimed to investigate the clinical efficacy of vacuum-assisted closure (VAC) combined with grafting of artificial dermis and autologous epidermis in the repair of refractory wounds.
   Patients with refractory wounds underwent debridement. Then the VAC device was used to culture wound granulation tissue. After the wound granulation tissue began to grow, artificial dermis was grafted on the wounds with VAC treatment. Then autologous epidermis was grafted on the artificial dermis to repair the wounds after survival of the artificial epidermis. The study mainly observed length of the hospital stay, survival of the artificial dermis, time required for culture of the granulation tissue using VAC before grafting of the artificial dermis, survival time of the artificial dermis, survival conditions of the autologous epidermis, influence on functions of a healed wound at a functional part, healing conditions of donor sites, and recurrence conditions of the wounds.
   Healing was successful for 22 patients (95.7%), but treatment failed for 1 child. The 22 patients were followed up for 6 to 24 months. According to follow-up findings, the skin grafts had good color and a soft texture. They were wear resistant and posed no influence on function. The appearance of the final results was the same as that of the full-thickness skin graft. Mild or no pigmentation and no scar formation occurred at the donor sites, and the wounds did not recur.
   Vacuum-assisted closure combined with grafting of artificial dermis and autologous epidermis is an effective means for repairing refractory wounds and is worth clinical popularizing and application.
   This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.spinger.com/00266.
C1 [Zhang, Chenwei; Liu, Dalie] Southern Med Univ, Zhujiang Hosp, Dept Plast Surg, Guangzhou 510282, Guangdong, Peoples R China.
   [Zhang, Chenwei; Liang, Zhi; Liu, Fei; Lin, Haibo; Guo, Zhengdong] Guangdong Med Coll, Dept Plast Surg, Affiliated Nanshan Hosp, Shenzhen 518052, Peoples R China.
C3 Southern Medical University - China; Guangdong Medical University
RP Liu, DL (通讯作者)，Southern Med Univ, Zhujiang Hosp, Dept Plast Surg, Guangzhou 510282, Guangdong, Peoples R China.
EM dalieliu2008@126.com
RI Liu, Fei/AAW-6037-2021
FU Shenzhen Science and Technology Program [201203226]
FX The research was supported by the Shenzhen Science and Technology
   Program (No. 201203226).
CR [Anonymous], BR J PLAST SURG
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NR 22
TC 9
Z9 12
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2014
VL 38
IS 4
BP 727
EP 732
DI 10.1007/s00266-014-0341-3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AM5AE
UT WOS:000339866500015
PM 24902915
DA 2026-07-24
ER

PT J
AU Ivanzov, S
   Soynov, I
   Kulyabin, Y
   Zubritskiy, A
   Voitov, A
   Omelchenko, A
   Arkhipov, A
   Bogachev-Prokophiev, A
AF Ivanzov, Sergey
   Soynov, Ilya
   Kulyabin, Yuriy
   Zubritskiy, Alexey
   Voitov, Alexey
   Omelchenko, Alexander
   Arkhipov, Alexey
   Bogachev-Prokophiev, Alexander
TI Vacuum-assisted closure versus closed irrigation for deep sternal wound
   infection treatment in infants: a propensity score-matched study
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure therapy; Closed irrigation drainage technique;
   Sepsis; Recurrence of mediastinitis
ID PEDIATRIC CARDIAC-SURGERY; RISK ADJUSTMENT; MEDIASTINITIS; CHILDREN;
   PREVENTION; MANAGEMENT; STERNOTOMY; RUPTURE
AB OBJECTIVES: This study aimed to compare vacuum-assisted closure therapy (VAC) and closed irrigation drainage therapy (CID) for deep sternal wound infection treatment in infants.
   METHODS: From January 2008 to March 2018, 69 patients (1.73%) had deep sternal wound infection. They were divided into 2 groups: patients treated with VAC therapy (VAC group, 29 patients) and those treated with CID therapy (CID group, 40 patients). After performing a propensity score analysis (1:1) for the entire sample, 16 patients receiving VAC therapy were matched with 16 patients receiving CID therapy.
   RESULTS: No significant difference was noted between both groups regarding age [d=0.045; 95% confidence interval (CI) 0.99-1.07], gender (d=0.001; 95% CI 0.22-4.45), weight (d=0.011; 95% CI 0.73-1.35), body surface area (d=-0.023; 95% CI 0.01-5733.08), cardiopulmonary bypass (d=0; 95% CI 0.16-5.90) and open chest duration (d=-0.112; 95% CI 0.31-5.16). Five patients died in the CID group (31.25%) during hospital stay, and there were no deaths in the VAC group (P=0.024). Recurrence of mediastinitis occurred in 1 patient (6.25%) from the VAC group and in 6 patients (37.5%) from the CID group (P=0.037). The multivariable regression analysis revealed that the CID method was the only risk factor for remediastinitis (odds ratio 17.3; 95% CI 1.04-286.75; P=0.046).
   CONCLUSIONS: Use of VAC therapy in infants with deep sternal wound infection was associated with a substantial decrease in the mortality rate and duration of therapy compared with CID technique. The CID technique was an independent risk factor for recurrence of mediastinitis.
C1 [Ivanzov, Sergey; Soynov, Ilya; Kulyabin, Yuriy; Zubritskiy, Alexey; Voitov, Alexey; Omelchenko, Alexander; Arkhipov, Alexey; Bogachev-Prokophiev, Alexander] Natl Med Res Ctr, Dept Congenital Heart Dis, Rechkunovskaya St 15, Novosibirsk 630055, Russia.
C3 Meshalkin National Medical Research Center
RP Soynov, I (通讯作者)，Natl Med Res Ctr, Dept Congenital Heart Dis, Rechkunovskaya St 15, Novosibirsk 630055, Russia.
EM I_soynov@mail.ru
RI Kulyabin, Yuriy/O-8941-2017; Voitov, Alexey/AAC-9988-2022; Soynov,
   Ilya/AAD-9872-2020
OI Kulyabin, Yuriy/0000-0002-2361-5847; Arkhipov,
   Alexey/0000-0003-3234-5436; Zubritskiy, Alexey/0000-0003-4666-2571;
   Voitov, Alexey/0000-0003-3797-4899; Soynov, Ilya/0000-0003-3691-2848
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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NR 27
TC 6
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD NOV
PY 2019
VL 29
IS 5
BP 776
EP 782
DI 10.1093/icvts/ivz167
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA JP3KX
UT WOS:000498167500018
PM 31361302
OA Bronze
DA 2026-07-24
ER

PT J
AU Sea, S
   Meckmongkol, T
   Moront, ML
   Timmapuri, S
   Prasad, R
   Schwartz, MZ
   Arthur, LG
AF Sea, Stephanie
   Meckmongkol, Teerin
   Moront, Matthew L.
   Timmapuri, Shaheen
   Prasad, Rajeev
   Schwartz, Marshall Z.
   Arthur, L. Grier
TI Vacuum-Assisted Closure: A Novel Method of Managing Surgical Necrotizing
   Enterocolitis
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE necrotizing enterocolitis; abdominal compartment syndrome;
   vacuum-assisted closure
ID ABDOMINAL COMPARTMENT SYNDROME; NEGATIVE-PRESSURE; MANAGEMENT; THERAPY
AB PurposeNecrotizing enterocolitis (NEC) requiring surgical intervention is associated with mortality rates approaching 50%. We evaluated outcomes of patients that underwent surgical treatment for NEC with vacuum-assisted closure (VAC) of the abdomen as compared with traditional laparotomy, bowel resection, and ostomy creation.
   MethodsA retrospective review identified 26 patients from 2007 to 2012 with NEC. Overall, 17 patients were treated with laparotomy, and 9 were treated with laparotomy and VAC (LapVac). Age, weight, preoperative and postoperative mean airway pressure, length of bowel resected, duration on total peripheral nutrition, time until initiation of feeds, and length of stay were assessed. A Student's t-test was used for statistical analysis.
   ResultsNine LapVac patients underwent a total of 1.21.3 VAC changes and had open abdomens for 13.1 +/- 19.1 days. LapVac and traditional laparotomy patients had similar outcomes with respect to amount of bowel resected, time on a ventilator, time to initiation of feeds, and length of hospital stay. Two of nine patients (22%) in the LapVac group were placed in continuity without the need for an ostomy. We identified a subset of patients in the LapVac group that demonstrated signs of abdominal compartment syndrome (ACS), exhibiting mean airway pressures greater than 15 cm H2O preoperatively. Patients with ACS treated with VAC therapy had shorter time to initiation of feeds (p=0.047) and shorter lengths of stay (p=0.0395) as compared with traditional laparotomy.
   ConclusionOur data demonstrate that use of the wound VAC is a safe approach in the management of premature infants with NEC requiring surgical intervention with outcomes comparable to standard surgical management. Use of the wound VAC may allow the establishment of bowel continuity and abdominal closure without the need for an ostomy. VAC therapy may also hasten the recovery of NEC patients with concomitant ACS by eliminating the compartment syndrome. Larger studies are required to confirm this theory.
C1 [Sea, Stephanie; Meckmongkol, Teerin; Moront, Matthew L.; Timmapuri, Shaheen; Prasad, Rajeev; Schwartz, Marshall Z.; Arthur, L. Grier] St Christophers Hosp Children, Dept Pediat Surg, Philadelphia, PA 19134 USA.
RP Sea, S (通讯作者)，St Christophers Hosp Children, Dept Pediat Surg, 3601 A St, Philadelphia, PA 19134 USA.
EM stephanieasea@gmail.com; Grier.Arthur@tenethealth.com
OI Meckmongkol, Teerin/0000-0003-4868-1725
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
   Batacchi S, 2009, CRIT CARE, V13, DOI 10.1186/cc8193
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NR 17
TC 10
Z9 13
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD FEB
PY 2015
VL 25
IS 1
BP 41
EP 45
DI 10.1055/s-0034-1387940
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA AZ9HL
UT WOS:000348524500010
PM 25172983
OA Bronze
DA 2026-07-24
ER

PT J
AU Iacovelli, V
   Cipriani, C
   Sandri, M
   Filippone, R
   Ferracci, A
   Micali, S
   Rocco, B
   Puliatti, S
   Ferrarese, P
   Benedetto, G
   Minervini, A
   Cocci, A
   Pastore, AL
   Al Salhi, Y
   Antonelli, A
   Morena, T
   Volpe, A
   Poletti, F
   Celia, A
   Zeccolini, G
   Leonardo, C
   Proietti, F
   Agrò, EF
   Bove, P
AF Iacovelli, Valerio
   Cipriani, Chiara
   Sandri, Marco
   Filippone, Roberta
   Ferracci, Antonella
   Micali, Salvatore
   Rocco, Bernardo
   Puliatti, Stefano
   Ferrarese, Paolo
   Benedetto, Giuseppe
   Minervini, Andrea
   Cocci, Andrea
   Pastore, Antonio Luigi
   Al Salhi, Yazan
   Antonelli, Alessandro
   Morena, Tonino
   Volpe, Alessandro
   Poletti, Filippo
   Celia, Antonio
   Zeccolini, Guglielmo
   Leonardo, Costantino
   Proietti, Flavia
   Agro, Enrico Finazzi
   Bove, Pierluigi
TI The role of vacuum-assisted closure (VAC) therapy in the management of
   FOURNIER'S gangrene: a retrospective multi-institutional cohort study
SO WORLD JOURNAL OF UROLOGY
LA English
DT Article
DE Fournier's gangrene; Necrotizing fasciitis; Vacuum-assisted closure
   therapy; VAC; Wound therapy; Overall survival
ID HYPERBARIC-OXYGEN THERAPY
AB Purpose To explore the role of vacuum assisted closure (VAC) therapy versus conventional dressings in the Fournier's gangrene wound therapy. Patients and Methods This is a retrospective multi-institutional cohort study. Data of 92 patients from nine centers between 2007 and 2018 were retrospectively analyzed. After surgery, patient having a local or a disseminated FG were managed with VAC therapy or with conventional dressings. The 10-weeks wound closure cumulative rate and OS were analyzed. Results Of the 92 patients, 62 (67.4%) showed local and 30 (32.6%) a disseminated FG. After surgery, 19 patients (20.7%) with local and 14 (15.2%) with disseminated FG underwent to VAC therapy; 43 (46.7%) with local and 16 (17.4%) with disseminated FG were treated using conventional dressings. The multivariable logistic regression analysis demonstrated that the VAC in patients with disseminated FG led to a higher cumulative rate of wound closure than patients treated with no-VAC (OR = 6.5; 95% CI 1.1-37.4, p = 0.036). The Kaplan-Meier survival curves for the OS showed a significant difference between no-VAC patients with local and disseminated FG (OS rate at 90 days 0.90, 95% CI 0.71-0.97 vs 0.55, 95% CI 0.24-0.78, respectively; p = 0.039). Cox regression confirmed that no-VAC patients with disseminated FG showed the lowest OS (hazard ratio adjusted for sex and age HR = 3.4, 95% CI 1.1-10.4; p = 0.033). Conclusions In this large cohort study, VAC therapy in patients with disseminated FG may offer an advantage in terms of 10-weeks wound closure cumulative rate and OS at 90 days after initial surgery.
C1 [Iacovelli, Valerio; Cipriani, Chiara; Cocci, Andrea; Bove, Pierluigi] GVM Care & Res, Urol Unit, San Carlo Nancy Hosp, Via Aurelia 275, I-00100 Rome, Italy.
   [Iacovelli, Valerio; Filippone, Roberta; Agro, Enrico Finazzi] Univ Tor Vergata, Dept Surg Sci, Rome, Italy.
   [Sandri, Marco] Univ Brescia, Data Methods & Syst Stat Lab, Brescia, Italy.
   [Ferracci, Antonella] Policlin Tor Vergata Fdn, Dept Surg, Rome, Italy.
   [Micali, Salvatore; Rocco, Bernardo; Puliatti, Stefano] Univ Modena & Reggio Emilia, Dept Urol, Osped Policlin, Modena, Italy.
   [Micali, Salvatore; Rocco, Bernardo; Puliatti, Stefano] Univ Modena & Reggio Emilia, Nuovo Osped Civile S Agostino Estense Modena, Modena, Italy.
   [Ferrarese, Paolo; Benedetto, Giuseppe] San Bortolo Hosp, Urol Unit, Vicenza, Italy.
   [Minervini, Andrea] Univ Florence, Careggi Hosp, Dept Urol, Florence, Italy.
   [Pastore, Antonio Luigi; Al Salhi, Yazan] ICOT Latina, Dept Urol, Latina, Italy.
   [Antonelli, Alessandro; Morena, Tonino] Univ Hosp Verona, Dept Surg Dent Paediat & Gynaecol, Urol Unit, Borgo Gen Hosp, Trento, Italy.
   [Volpe, Alessandro; Poletti, Filippo] Univ Piemonte Orientale, Maggiore Carita Hosp, Dept Urol, Novara, Italy.
   [Celia, Antonio; Zeccolini, Guglielmo] San Bassiano Hosp, Dept Urol, Bassano Del Grappa, Italy.
   [Leonardo, Costantino; Proietti, Flavia] Univ Roma La Sapienza, Dept Uroll, Rome, Italy.
C3 University of Rome Tor Vergata; University of Brescia; Universita di
   Modena e Reggio Emilia; Universita di Modena e Reggio Emilia; ULSS 8
   Berica; Ospedale San Bortolo di Vicenza; University of Florence; Azienda
   Ospedaliero Universitaria Careggi; University of Eastern Piedmont Amedeo
   Avogadro; ULSS 7 Pedemontana; Ospedale San Bassiano; Sapienza University
   Rome
RP Iacovelli, V (通讯作者)，GVM Care & Res, Urol Unit, San Carlo Nancy Hosp, Via Aurelia 275, I-00100 Rome, Italy.; Iacovelli, V (通讯作者)，Univ Tor Vergata, Dept Surg Sci, Rome, Italy.
EM valerio.iacovelli85@gmail.com
RI BOVE, PIERLUIGI/AAR-7019-2020; Cipriani, Chiara/AAC-3669-2022; Puliatti,
   Stefano/AAS-8339-2021; Minervini, Anea/AAB-8926-2019; FINAZZI AGRO,
   ENRICO/N-7969-2018; Proietti, Flavia/LSI-6771-2024; Cocci,
   Andrea/C-9735-2018; Iacovelli, Valerio/HJI-2832-2023; Sandri,
   Marco/L-2875-2013; antonelli, alessandro/AAU-2291-2020; PASTORE, ANTONIO
   LUIGI/F-1687-2011; Leonardo, Costantino/AAH-8609-2019; Micali,
   Salvatore/J-8179-2016
OI BOVE, PIERLUIGI/0000-0002-4788-2982; Cipriani,
   Chiara/0000-0001-7085-4966; Puliatti, Stefano/0000-0002-1597-9595;
   Minervini, Anea/0000-0001-5140-4628; FINAZZI AGRO,
   ENRICO/0000-0002-0308-8824; Proietti, Flavia/0000-0002-6478-8584; Cocci,
   Andrea/0000-0003-0138-6294; AL SALHI, YAZAN/0009-0005-1707-9485;
   Iacovelli, Valerio/0000-0001-5138-3177; Sandri,
   Marco/0000-0002-1422-5695; antonelli, alessandro/0000-0002-7455-8803;
   PASTORE, ANTONIO LUIGI/0000-0003-4293-9174; 
CR Assenza M, 2011, CLIN TER, V162, pE1
   Bonkat G, 2019, EUROPEAN ASS UROLOGY
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   Yücel M, 2017, ULUS TRAVMA ACIL CER, V23, P400, DOI 10.5505/tjtes.2017.01678
NR 27
TC 36
Z9 47
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0724-4983
EI 1433-8726
J9 WORLD J UROL
JI World J. Urol.
PD JAN
PY 2021
VL 39
IS 1
SI SI
BP 121
EP 128
DI 10.1007/s00345-020-03170-7
EA MAR 2020
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA QC0TY
UT WOS:000522711700001
PM 32236663
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Bahceci, T
   Aydogan, O
   Koyuncu, E
   Ergun, KE
   Kalemci, MS
AF Bahceci, Tuncer
   Aydogan, Ozan
   Koyuncu, Efekan
   Ergun, Kasim Emre
   Kalemci, Mustafa Serdar
TI Wound Management Practices in Scrotal-Confined Fournier's Gangrene
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Fournier gangrene; Wound care; Vacuum-assisted closure; Conventional
   dressing; Length of hospitalisation
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE
AB Objective: To compare real-world outcomes of different wound care strategies following surgical debridement in scrotal-confined Fournier Gangrene (FG), without inferring causality. Study Design: Observational study. Place and Duration of the Study: Department of Urology, Aydin Adnan Menderes University, and Ege University, Izmir, Turkiye, from August 2013 to October 2023. Methodology: Eighty-six patients with scrotal-confined FG were included. They were divided into three postoperative wound care groups: Group 1 used gauze impregnated with rifampicin and nitrofurantoin, Group 2 used rivanol-impregnated gauze, and Group 3 used vacuum-assisted closure (VAC). Data on demographics, microbial profiles, antibiotic use, and clinical outcomes (including hospital stay) were recorded. Group comparisons were performed using one-way ANOVA, Kruskal-Wallis, or Chi-square tests as appropriate. Results: The patients' age ranged from 26 to 96 years (mean 63.9 years). The most common single morbidity was diabetes (29.1%). Predominant pathogens were polymicrobial (24.4%) and E. coli (23.3%) in isolation. Overall mortality was 5.8%. Median hospital stays were 9 days (range: 5-28) in Group 1, compared to 14 days (6-40) and 15 days (6-31) in Groups 2 and 3, respectively (p <0.001), with Group 1 being significantly shorter. Secondary debridement rates were similar across groups: 12.5% in Group 1, 37.5% in Group 2, 50% in Group 3 (p = 0.32). Antibiotic choices differed significantly among the groups (p <0.001). Notably, the triple combination regimen of daptomycin, tigecycline, and meropenem was not used in Group 1. Conclusion: Topical antibiotic dressing using mesh dressings impregnated with rifampicin and nitrofurantoin was associated with a shorter hospitalisation compared to rivanol and VAC therapy in scrotal-confined FG. These findings suggest that rifampicin and nitrofurantoin-based topical therapy may be viable alternatives in resource-limited settings, or where VAC is unavailable.
C1 [Bahceci, Tuncer; Aydogan, Ozan] Aydin Adnan Menderes Univ, Dept Urol, Aydin, Turkiye.
   [Koyuncu, Efekan; Ergun, Kasim Emre; Kalemci, Mustafa Serdar] Ege Univ, Dept Urol, Izmir, Turkiye.
C3 Adnan Menderes University; Ege University
RP Bahceci, T (通讯作者)，Aydin Adnan Menderes Univ, Dept Urol, Aydin, Turkiye.
EM tuncerbahceci@adu.edu.tr
RI bahceci, tuncer/LWK-0430-2024; /ABH-2146-2021; ergün, kasım
   emre/DLK-3027-2022
OI Aydoğan, Ozan/0009-0003-9424-7492
CR Altunoluk Bulent, 2012, ISRN Urol, V2012, P762340, DOI 10.5402/2012/762340
   Assenza M, 2011, CLIN TER, V162, pE1
   Babalska ZL, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14121253
   Bali ZU, 2020, J UROL SURG, V7, P42, DOI 10.4274/jus.galenos.2019.3013
   Çakmak A, 2008, ADV THER, V25, P1065, DOI 10.1007/s12325-008-0103-1
   Chawla SN, 2003, EUR UROL, V43, P572, DOI 10.1016/S0302-2838(03)00102-7
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   Zimmerli W, 2019, ANTIMICROB AGENTS CH, V63, DOI 10.1128/AAC.01746-18
NR 24
TC 0
Z9 0
U1 3
U2 8
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD AUG
PY 2025
VL 35
IS 8
BP 981
EP 986
DI 10.29271/jcpsp.2025.08.981
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9HG6S
UT WOS:001606320200008
PM 40843563
OA gold
DA 2026-07-24
ER

PT J
AU Vuerstaek, JDD
   Vainas, T
   Wuite, J
   Nelemans, P
   Neumann, MHA
   Veraart, JCJM
AF Vuerstaek, Jeroen D. D.
   Vainas, Tryfon
   Wuite, Jan
   Nelemans, Patty
   Neumann, Martino H. A.
   Veraart, Joep C. J. M.
TI State-of the-art treatment of chronic leg ulcers: a randomized
   controlled trial comparing vacuum-assisted closure (VAC) with modern
   wound dressings
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID BED PREPARATION; VENOUS ULCERS
AB Background: Current treatment modalities for chronic leg ulcers are time consuming, expensive, and only moderately successful. Recent data suggest that creating a subatmospheric pressure by vacuum-assisted closure (V.A.C., KCI Concepts, San Antonio, Texas) therapy supports the wound healing process.
   Methods: The efficacy of vacuum-assisted closure in the treatment of chronic leg ulcers was prospectively studied in a randomized controlled trial in which 60 hospitalized patients with chronic leg ulcers were randomly assigned to either treatment by V.A.C. or therapy with conventional wound care techniques. The primary outcome measure was the time to complete healing (days). Statistical analysis was performed on the intention-to-treat basis.
   Results. The median time to complete healing was 29 days (95% confidence interval [CI], 25.5 to 32.5) in the V.A.C. group compared with 45 days (95% CI, 36.2 to 53.8) in the control group (P=.0001). Further, wound bed preparation during V.A.C. therapy was also significantly shorter at 7 days (95% C1 5.7 to 8.3) than during conventional wound care at 17 days (95% CI, 10 to 24, P=.005). The costs of conventional wound care were higher than those of V.A.C. Both groups showed a significant increase in quality of life at the end of therapy and a significant decrease in pain scores at the end of follow-up.
   Conclusions: V.A.C. therapy should be considered as the treatment of choice for chronic leg ulcers owing to its significant advantages in the time to complete healing and wound bed preparation time compared with conventional wound care. Particularly during the preparation stage, V.A.C. therapy appears to be superior to conventional wound care techniques.
C1 DermaClin, B-3600 Ghent, Belgium.
   Univ Hosp Maastricht, Dept Dermatol, Maastricht, Netherlands.
   Univ Hosp Maastricht, Dept Surg, Maastricht, Netherlands.
   Atrium Med Ctr, Dept Dermatol, Heerlen, Netherlands.
   Univ Maastricht, Dept Epidemiol, Maastricht, Netherlands.
   Erasmus MC, Dept Dermatol, Rotterdam, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Atrium Medical Center; Maastricht University; Erasmus University
   Rotterdam; Erasmus MC
RP Vuerstaek, JDD (通讯作者)，DermaClin, Collegelaan 10, B-3600 Ghent, Belgium.
EM info@DermaClinic.be
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NR 37
TC 269
Z9 321
U1 0
U2 20
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2006
VL 44
IS 5
BP 1029
EP 1037
DI 10.1016/j.jvs.2006.07.030
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 101BQ
UT WOS:000241714300029
PM 17000077
OA Bronze
DA 2026-07-24
ER

PT J
AU Benninger, E
   Labler, L
   Seifert, B
   Trentz, O
   Menger, MD
   Meier, C
AF Benninger, Emanuel
   Labler, Ludwig
   Seifert, Burkhardt
   Trentz, Otmar
   Menger, Michael D.
   Meier, Christoph
TI In vitro comparison of intra-abdominal hypertension development
   after different temporary abdominal closure techniques
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE temporary abdominal closure; intra-abdominal pressure; intra-abdominal
   hypertension; abdominal compartment syndrome; vacuum assisted closure;
   VAC
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; SILO CLOSURE; TRAUMA; FOUNDATION; WOUNDS
AB Background. To compare volume reserve capacity (VRC) and development of intra-abdominal hypertension after different in vitro temporary abdominal closure (TAC) techniques.
   Methods. A model of the abdomen was designed. The abdominal wall was simulated with polychloroprene, a synthetic rubber compound. A lentil-shaped defect of 150 cm(2) was cut into the anterior aspect of the abdominal wall. TAC of this defect was performed by a zipper system (ZS), a bag silo closure (BSC), or a vacuum assisted closure (VAC) with subatmospheric pressures ranging from 0- to 200 mmHg. The model with intact abdominal wall served as reference. The model was filled with water to baseline level. The intra-abdominal pressure was increased in 2 mmHg steps from baseline level (6 mmHg) to 40 mmHg by adding volume to the system according to a standardized protocol. VRC with corresponding intra-abdominal pressure were analyzed and compared for the different TAC techniques.
   Results. VRC was the highest after BSC at all pressure levels studied (P < 0.05). VAC and ZS resulted in significantly lower VRC compared with BSC and reference (P < 0.05). The magnitude of negative pressure on the VAC did not significantly influence the VRC.
   Conclusions. In the present in vitro model, BSC demonstrated the highest VRC of all evaluated TAC techniques. Different levels of subatmospheric pressures applied to the VAC did not affect VRC. The results for ZS and VAC indicate that these TAC techniques may increase the risk for recurrent intra-abdominal hypertension and should therefore not be used in high-risk patients during the initial phase after abdominal decompression. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Benninger, Emanuel; Labler, Ludwig; Trentz, Otmar; Meier, Christoph] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Seifert, Burkhardt] Univ Zurich, ISPM, Dept Biostat, Zurich, Switzerland.
   [Menger, Michael D.] Univ Saarland, Inst Clin & Expt Surg, D-6650 Homburg, Germany.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   Saarland University
RP Meier, C (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM meierpucillo@hispeed.ch
OI Seifert, Burkhardt/0000-0002-5829-2478
CR [Anonymous], EUR J TRAUMA
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NR 15
TC 16
Z9 16
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD JAN
PY 2008
VL 144
IS 1
BP 102
EP 106
DI 10.1016/j.jss.2007.02.021
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 246MA
UT WOS:000252009900015
PM 17764694
DA 2026-07-24
ER

PT J
AU Book, T
   Wortmann, N
   Winkler, M
   Kirstein, MM
   Heidrich, B
   Wedemeyer, H
   Voigtländer, T
AF Book, Thorsten
   Wortmann, Nicolas
   Winkler, Michael
   Kirstein, Martha M.
   Heidrich, Benjamin
   Wedemeyer, Heiner
   Voigtlaender, Torsten
TI Endoscopic vacuum assisted closure (E-VAC) of upper gastrointestinal
   leakages
SO SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Endoscopic vacuum-assisted closure( E-VAC); esophageal perforations;
   postoperative leakage; gastrointestinal leakages; esophagogastrostomies
ID DEVICE
AB Objectives Endoscopic vacuum-assisted closure (E-VAC) of leaks of the upper gastrointestinal tract is an increasingly applied endoscopic technique. Data on indication, clinical success, complications and prognostic factors are still sparse. Methods Patients treated with E-VAC between 2012 and 2019 at a tertiary referral center have been retrospectively analyzed. Results Overall, 116 patients treated with E-VAC were identified. Indication for E-VAC placement was postoperative leakage in 94/116 (81%), iatrogenic perforations 7/116 (6%) and others 15/116 (13%). In 92/116 (79%) of the patients E-VAC therapy showed successful wound closure. The first E-VAC after detection of insufficiency was significantly more often placed intracavitary in patients with E-VAC failure (p = .031). There was a trend for longer intensive care unit treatment for patients with E-VAC failure (p = .069). Complications occurred significantly more often in patients with E-VAC failure (p = .009). Platelet count was significantly higher in patients with E-VAC success at day of insufficiency detection (257/Thsd/mu L (interquartile range [IQR], 185-362) vs. 195 (IQR, 117-309); p = .039). Platelet count (375 Thsd/mu L (IQR, 256-484) vs. 190 (IQR, 129-292)), hemoglobin (9.5 g/dL (IQR, 8.8-10.1) vs. 8.7 g/dL (IQR, 8.15-9.35)) and C-reactive protein level (79 mg/L (IQR, 39.7-121.9) vs. 152 mg/L (IQR, 73.7-231)) at day 14 differed significantly. The 30 days mortality rate was 33.3% (8/24) in E-VAC failure compared with 2.2% in patients with E-VAC success (p = .001). Conclusions E-VAC is an emerging highly effective interventional endoscopic technique for gastrointestinal wound closure even in highly selected patients.
C1 [Book, Thorsten; Heidrich, Benjamin; Wedemeyer, Heiner; Voigtlaender, Torsten] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Wortmann, Nicolas] Univ Hosp Munster, Dept Gastroenterol & Hepatol, Munster, Germany.
   [Winkler, Michael] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Hannover, Germany.
   [Kirstein, Martha M.] Univ Med Ctr Schleswig Holstein, Dept Med 1, Lubeck, Germany.
C3 Hannover Medical School; University of Munster; Hannover Medical School;
   University of Kiel; Schleswig Holstein University Hospital
RP Voigtländer, T (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM voigtlaender.torsten@mh-hannover.de
CR Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
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NR 15
TC 10
Z9 10
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5521
EI 1502-7708
J9 SCAND J GASTROENTERO
JI Scand. J. Gastroenterol.
PD NOV 2
PY 2021
VL 56
IS 11
BP 1376
EP 1379
DI 10.1080/00365521.2021.1963836
EA AUG 2021
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WI2SV
UT WOS:000687082600001
PM 34420453
DA 2026-07-24
ER

PT J
AU Shi, ST
   Wei, JY
   Lyu, GZ
   Zhong, XH
   Zhu, LH
   Yang, ML
AF Shi, Shuting
   Wei, Jiayu
   Lyu, Guozhong
   Zhong, Xiaohui
   Zhu, Lihong
   Yang, Minlie
TI Application of Comfort Therapy under eCASH Concept in Acute and Chronic
   Wound Treatment
SO DERMATOLOGY AND THERAPY
LA English
DT Article
DE Comfort therapy; Continuous negative pressure therapy (CNPWT); eCASH;
   Hamilton Anxiety Scale (HAM-A); Intermittent negative pressure wound
   therapy (INPWT); Visual Analogue Score (VAS); Wound care
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; CARE; PAIN; IMPLEMENTATION;
   MANAGEMENT; SEDATION
AB Introduction Given the new ideas on wound care offered by the eCASH (early Comfort using Analgesia, minimal Sedatives, and maximal Humane care) and the substantial differences in clinical treatment between acute and chronic wounds, we aimed to investigate the effect of comfort therapy under the eCASH concept on analgesic sedation and accelerated wound healing in patients with acute or chronic wounds.Methods This randomized clinical study was conducted in two parts: acute wounds and chronic wounds. Patients with acute wounds were allocated into the acute wound control group (AWCG) and the acute wound experimental group (AWEG). Patients with chronic wounds were allocated into the chronic wound control group (CWCG) and two experimental groups, in which they received intermittent negative pressure therapy (IPTEG) and continuous negative pressure therapy (CPTEG). On the basis of the standard treatment for patients in the control group, eCASH therapy was used in the experimental groups. In addition, pain intensity and procedural anxiety were evaluated using the visual analogue score (VAS) and the Hamilton Anxiety Scale (HAM-A). In addition, clinical effects were assessed on the basis of the size of the surface area, rate of healing, and concentration of pro-inflammatory factors (IL-1, IL-6, TNF-alpha) and growth factors (VEGF, bFGF, TGF-beta 1).Results Compared with the control group, the VAS score and HAM-A score in the experimental groups were significantly decreased after intervention (P < 0.05). After intervention, the levels of IL-1 beta, IL-6, and TNF-alpha in AWEG, IPTEG, and CPTEG were significantly lower than those in AWCG. In addition, the levels of VEGF, bFGF, and TGF-beta 1 in IPTEG and CPTEG were significantly higher than those in CWCG (P < 0.05).Conclusion These results indicated that comfort therapy under the eCASH concept has a significant effect on ameliorating the pain and anxiety of patients, reducing the inflammatory reaction during the period of wound healing in the treatment of acute and chronic wounds.
C1 [Shi, Shuting; Wei, Jiayu; Lyu, Guozhong; Zhong, Xiaohui; Zhu, Lihong; Yang, Minlie] Jiangnan Univ, Wuxi Sch Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
   [Lyu, Guozhong; Zhu, Lihong; Yang, Minlie] Jiangnan Univ, Dept Burn & Plast Surg, Affiliated Hosp, Wuxi, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Zhu, LH; Yang, ML (通讯作者)，Jiangnan Univ, Wuxi Sch Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.; Zhu, LH; Yang, ML (通讯作者)，Jiangnan Univ, Dept Burn & Plast Surg, Affiliated Hosp, Wuxi, Peoples R China.
EM fbjyzlh@163.com; jndxyml@sina.com
RI 史, 舒婷/HJZ-0638-2023; Shi, Shuting/HJZ-0638-2023
OI 史, 舒婷/0000-0003-2630-7580; 
FU Wuxi Health Committee [Z201710]; Wuxi science and Technology Bureau
   [N20192003]
FX The journal's Rapid Service Fee was supported by the Wuxi Health
   Committee(Z201710), and Wuxi Science and Technology Bureau(N20192003).
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NR 36
TC 7
Z9 8
U1 1
U2 6
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD JAN
PY 2023
VL 13
IS 1
BP 299
EP 314
DI 10.1007/s13555-022-00852-5
EA DEC 2022
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 7R5VW
UT WOS:000894583200001
PM 36472790
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kanzler, C
   Maehlmann, K
   Lischer, CJ
AF Kanzler, Carolin
   Maehlmann, Kathrin
   Lischer, Christoph J.
TI Application of preventive negative pressure therapy on midline
   laparotomy incisions in horses - a retrospective study
SO PFERDEHEILKUNDE
LA German
DT Article
DE laparatomy; incision; surgical site infection (SSI); horse; ciNPT
ID SURGICAL SITE INFECTION; LONG-TERM SURVIVAL; ABDOMINAL-WALL
   RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY; COMPLICATION
   RATES; COLIC SURGERY; EXPLORATORY CELIOTOMY; RISK-FACTORS; PART 1
AB Negative pressure therapy on wounds (negative pressure wound therapy, NPWT) and surgical incisions (closed incision negative pressure therapy, ciNPT) have been identified as a beneficial factor for wound healing and the reduction of wound healing disorders in humans. Veterinary publications on negative pressure therapy have been focused on wound treatment rather than preventive use. The aim of this study was to evaluate the preventive use of negative pressure therapy on surgical incisions in horses (closed incision negative pressure therapy, ciNPT). In addition, factors effecting the short and long-term outcome of wound healing of midline incisions as well as return to athletic use after convalescence were evaluated. A population of 201 horses were included in this study. The surgical incisions of 57 horses were treated using sterile vacuum wound covers (Incision Management System, KCI Medizinprodukte GmbH, Wiesbaden). The control group consisted of 144 horses with surgical incisions treated with standard wound covers (dry, non-adhesive wound dressing). Factors such as breed, gender, age, weight, vital and laboratory parameters, intraoperative diagnosis, number of laparotomies performed, duration of surgery and anesthesia time and wound healing disorders were associated to outcome. Outcome parameters, including wound infection after the hospitalization, abdominal hernia, colic after convalescence, postoperative use and level of performance were collected from owners via standardized telephone questionnaire. No significant difference was found between laparotomy incisions treated with ciNPT compared to standard wound dressings. Significant effects were found between wound infection and heart rate on arrival in the clinic, internal body temperature on day 5 and 10 after surgery, white blood cell count on day 5 after surgery, diagnosis, duration of surgery and general anesthesia time. Horses with small intestinal disease in combination with colonic enterotomy and horses that required repeated laparotomy had a significantly higher risk of developing an abdominal hernia, compared to the rest of this population. Closed incision negative pressure therapy cannot be recommended for the reduction of wound healing disorders after midline laparotomy in horses.
C1 [Kanzler, Carolin; Maehlmann, Kathrin; Lischer, Christoph J.] Free Univ Berlin, Klin Pferde, Berlin, Germany.
C3 Free University of Berlin
RP Kanzler, C (通讯作者)，Bohlaustr 7, D-99423 Weimar, Germany.
EM carolinkanzler2701@gmail.com
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NR 71
TC 0
Z9 0
U1 0
U2 5
PU HIPPIATRIKA VERLAG MBH
PI STUTTGART
PA POSTFACH 102251, 70018 STUTTGART, GERMANY
SN 0177-7726
J9 PFERDEHEILKUNDE
JI Pferdeheilkunde
PD JUL-AUG
PY 2023
VL 39
IS 4
BP 332
EP 346
DI 10.21836/PEM20230404
PG 15
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA R7BV5
UT WOS:001065878600004
OA gold
DA 2026-07-24
ER

PT J
AU Levy, AS
   Altchek, CL
   McMillen, EM
   Karinja, SJ
   Tiao, JR
   Smith, CR
   Ascherman, JA
AF Levy, Adam S.
   Altchek, Chloe L.
   McMillen, Elizabeth M.
   Karinja, Sarah J.
   Tiao, Jonathan R.
   Smith, Craig R.
   Ascherman, Jeffrey A.
TI An Outcomes Review of 330 Sternal Wound Reconstructions: Timing of
   Closure Does Make a Difference
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; MYOCUTANEOUS ADVANCEMENT FLAPS;
   CARDIAC-SURGERY; MANAGEMENT; COMPLICATIONS; DEBRIDEMENT; INFECTION
AB Background: Sternal wound infection and dehiscence following cardiac surgery remain difficult clinical problems with high morbidity. Older classification systems regarding timing to reconstruction do not take into account recent improvements in critical care, wound vacuum-assisted closure use, or next-generation antibiotic therapies, which may prolong time to reconstruction.
   Methods: Records of patients undergoing sternal wound reconstruction performed by the senior author (J.A.A.) from 1996 to 2018 at a high-volume cardiac surgery center were reviewed. Indications included sternal wound infection or dehiscence. All patients underwent single-stage removal of hardware, debridement, and flap closure. Patients were divided into two groups based on timing of wound closure after cardiac surgery: less than 30 days or greater than or equal to 30 days.
   Results: Of the 505 patients identified during the study period, 330 had sufficient data for analysis. Mean time to sternal wound surgery was 15.7 days in the early group compared to 64.4 days (p < 0.01) beyond 30 days. Postdebridement cultures were positive in 72 percent versus 62.5 percent of patients (p = 0.11), whereas rates of postoperative infection were significantly higher in the delayed group: 1.9 percent versus 9.5 percent (p < 0.01). Partial wound dehiscence rates were also higher after 30 days (1.9 percent versus 11.3 percent; p < 0.01), whereas total length of stay was decreased. Use of wound vacuum-assisted closure was significantly associated with reconstruction beyond 30 days (p < 0.01).
   Conclusions: Although performing sternal wound reconstruction more than 30 days after initial cardiac surgery was associated with a shorter overall hospital length of stay and higher extubation rates in the operating room, these patients also had elevated postoperative infection and wound complication rates. The authors thus recommend not delaying definitive surgical reconstruction when possible.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
C1 Columbia Univ, Dept Surg, Div Plast Surg, Irving Med Ctr, New York, NY 10032 USA.
   Columbia Univ, Dept Surg, Div Cardiothorac Surg, Irving Med Ctr, New York, NY 10032 USA.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital; Columbia University; Cornell University; Weill Cornell
   Medicine; NewYork-Presbyterian Hospital; Columbia University
RP Ascherman, JA (通讯作者)，Columbia Univ, Med Ctr, 161 Ft Washington Ave,Suite 51, New York, NY 10032 USA.
EM jaa7@cumc.columbia.edu
OI Karinja, Sarah/0009-0005-6431-2892
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NR 23
TC 9
Z9 9
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD AUG
PY 2021
VL 148
IS 2
BP 429
EP 437
DI 10.1097/PRS.0000000000008168
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TR4ZQ
UT WOS:000678974600075
PM 34398095
DA 2026-07-24
ER

PT J
AU Hake, ME
   Etscheidt, J
   Chadayammuri, VP
   Kirsch, JM
   Mauffrey, C
AF Hake, Mark E.
   Etscheidt, Jordan
   Chadayammuri, Vivek P.
   Kirsch, Jacob M.
   Mauffrey, Cyril
TI Age and dressing type as independent predictors of post-operative
   infection in patients with acute compartment syndrome of the lower leg
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Compartment syndrome; Delta P; Acute compartment syndrome; ACS
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FASCIOTOMY; DIAGNOSIS;
   MANAGEMENT; FRACTURES; CHILDREN
AB Purpose The purpose of this study was to determine independent factors, including timing of fasciotomy, that confer an increased risk of post-operative surgical site infection (SSI) in patients presenting with acute compartment syndrome (ACS) of the lower extremity.
   Methods A retrospective analysis was performed on a consecutive cohort of 53 adult patients requiring fasciotomy for lower-extremity fractures complicated by ACS presenting to a single Level I trauma center over a seven-year study period. The primary outcome measure was the incidence of SSI (as defined by the CDC) occurring within 12 months of fasciotomy. Explanatory variables including site of ACS, time of injury, time of fasciotomy, operative findings, and requirement for additional soft tissue coverage procedures were recorded for all patients. Multivariate regression was used to determine independent predictors of post-operative SSI.
   Results post-operative SSI was detected in 16 (30.2%) patients. Compared to infection-free patients, patients with post-operative SSI had a significantly higher median age (52.0 vs. 37.0 years, p = 0.010), frequency of intra-operative myonecrosis at time of fasciotomy (31.2% vs. 5.4%, p = 0.021), and requirement for negative-pressure wound therapy [NPWT] (93.7% vs. 45.9%, p = 0.002). Multivariate logistic regression analysis confirmed that requirement for NPWT (odds ratio [OR], 17.10; 95% confidence interval [CI], 1.78-164.0; p = 0.014) and increasing age (OR, 1.07; 95% CI, 1.01-1.14; p = 0.037) were independent predictors of post-operative SSI. Timing of fasciotomy following injury was not independently related to the risk of SSI.
   Conclusions ACS occurs on a spectrum of disease severity that evolves variably over time. Increasing age of the patient and requirement for NPWT following fasciotomy are independent predictors of post-operative SSI following emergent fasciotomy for ACS. Further studies are required to inform optimal treatment strategies in such patients.
C1 [Hake, Mark E.; Etscheidt, Jordan; Kirsch, Jacob M.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA.
   [Chadayammuri, Vivek P.] Univ Colorado, Sch Med, Aurora, CO USA.
   [Mauffrey, Cyril] Denver Hlth Med Ctr, Dept Orthopaed Surg, 777 Bannock St, Denver, CO 80204 USA.
C3 University of Michigan System; University of Michigan; University of
   Colorado System; University of Colorado Anschutz; Denver Health Medical
   Center
RP Mauffrey, C (通讯作者)，Denver Hlth Med Ctr, Dept Orthopaed Surg, 777 Bannock St, Denver, CO 80204 USA.
EM mauffreyc@gmail.com
RI ; Mauffrey, Cyril/M-3215-2014
OI Chadayammuri, Vivek/0000-0003-4870-6734; Mauffrey,
   Cyril/0000-0003-2132-3418
CR [Anonymous], SURG SIT INF SSI EV
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NR 27
TC 16
Z9 17
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD DEC
PY 2017
VL 41
IS 12
BP 2591
EP 2596
DI 10.1007/s00264-017-3576-1
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FM5OY
UT WOS:000415086800019
PM 28730321
DA 2026-07-24
ER

PT J
AU Game, FL
   Apelqvist, J
   Attinger, C
   Hartemann, A
   Hinchliffe, RJ
   Löndahl, M
   Price, PE
   Jeffcoate, WJ
AF Game, F. L.
   Apelqvist, J.
   Attinger, C.
   Hartemann, A.
   Hinchliffe, R. J.
   Londahl, M.
   Price, P. E.
   Jeffcoate, W. J.
CA Int Working Grp Diabet Foot IWGDF
TI Effectiveness of interventions to enhance healing of chronic ulcers of
   the foot in diabetes: a systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 2015 IWGDF Guidance on the Prevention and Management of Foot Problems in
   Diabetes
CY MAY 20-23, 2015
CL The Hague, NETHERLANDS
DE diabetes; diabetic foot; ulcer; wound healing; dressing
ID HYPERBARIC-OXYGEN THERAPY; COLONY-STIMULATING FACTOR; RANDOMIZED
   CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; CONTROLLED CLINICAL-TRIAL;
   FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; CRITICAL LIMB
   ISCHEMIA; DOUBLE-BLIND; ELECTRICAL-STIMULATION
AB The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas, which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between June 2010 and June 2014. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae or hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; oxygen and other gases, compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound and other systemic therapies, which did not fit in the aforementioned categories. Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papers identified, 30 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic reviews, and the conclusion is similar: that with the possible exception of negative pressure wound therapy in post-operative wounds, there is little published evidence to justify the use of newer therapies. Analysis of the evidence continues to present difficulties in this field as controlled studies remain few and the majority continue to be of poor methodological quality.
C1 [Game, F. L.] Derby Teaching Hosp NHS FT, Dept Diabet & Endocrinol, Uttoxeter Rd, Derby DE22 3NE, England.
   [Apelqvist, J.; Londahl, M.] Malmo Univ Hosp, Dept Endocrinol, Malmo, Sweden.
   [Attinger, C.] Medstar Georgetown Univ, Dept Plast Surg, Washington, DC USA.
   [Hartemann, A.] Univ Paris 06, ICAN, Pitie Salpetriere Hosp, APHP, F-75252 Paris 05, France.
   [Hinchliffe, R. J.] St Georges Healthcare NHS Trust, St Georges Vasc Inst, London, England.
   [Price, P. E.] Cardiff Univ, Vice Chancellors Off, Cardiff CF10 3AX, S Glam, Wales.
   [Jeffcoate, W. J.] Nottingham Univ Hosp NHS Trust, Dept Diabet & Endocrinol, Nottingham, England.
C3 Lund University; Skane University Hospital; Georgetown University;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Hopital Universitaire Ambroise-Pare - APHP;
   Sorbonne Universite; City St Georges, University of London; Cardiff
   University; Nottingham University Hospital NHS Trust
RP Game, FL (通讯作者)，Derby Teaching Hosp NHS FT, Dept Diabet & Endocrinol, Uttoxeter Rd, Derby DE22 3NE, England.
EM frances.game@nhs.net
OI Game, Frances/0000-0002-5294-4789; Löndahl, Magnus/0000-0003-1522-3920
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NR 148
TC 158
Z9 186
U1 1
U2 63
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
SU 1
BP 154
EP 168
DI 10.1002/dmrr.2707
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA DC3QP
UT WOS:000369134100015
PM 26344936
OA Bronze
DA 2026-07-24
ER

PT J
AU Caro, A
   Olona, C
   Jiménez, A
   Vadillo, J
   Feliu, F
   Vicente, V
AF Caro, Aleidis
   Olona, Carles
   Jimenez, Andrea
   Vadillo, Jordi
   Feliu, Francesc
   Vicente, Vicente
TI Treatment of the open abdomen with topical negative pressure therapy: a
   retrospective study of 46 cases
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal wound; Open abdomen; Topical negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMINAL WOUNDS; TEMPORARY CLOSURE;
   ENTEROCUTANEOUS FISTULA; LAPAROSTOMY; EXPERIENCE; MANAGEMENT; TRAUMA
AB The open abdomen is an ongoing challenge for professionals engaged in its treatment. The change in the integrity of the abdominal wall, the loss of fluids, heat and proteins and contamination of the wound are the main problems. The objective of this article is to describe our experience using the abdominal dressing vacuum-assisted closure therapy in treatment of the open abdomen. Since December 2006, all patients requiring treatment with the open abdomen technique have been treated with the abdominal dressing system and vacuum-assisted closure therapy (VAC (R) KCI, San Antonio, USA). The results obtained with this technique in non traumatic patients are analysed herein. The abdominal dressing system was used on 46 patients in the period between January 2006 and December 2009, with a mean 63 years old (29-80), with a gender distribution of 33 men (72%) and 13 women (28%). Closure of the abdominal wall was possible in 24 patients, 5 of which were primary in the recent postoperative phase, 5 had primary suture of the fascia and application of the supra-aponeurotic prosthesis and 14 had closure of the abdominal wall with a composite polytetrafluoroethylene (PTFE) and polypropylene mesh. Second intention closure took place in the remaining 22 patients (48%), as their conditions did not allow primary closure. The mean treatment time with abdominal dressing was 26 days (6-92) with an average of eight changes per patient. The abdominal dressing topical negative pressure system is a useful option for consideration in the event of needing to leaves the abdomen open. It stabilises the abdominal wall and quantifies and collects exudate from the wound, protects the intra-abdominal viscera and keeps the fascia intact and the cutaneous plane for subsequent closure of the wall.
C1 [Caro, Aleidis; Olona, Carles; Jimenez, Andrea; Vadillo, Jordi; Feliu, Francesc; Vicente, Vicente] Univ Rovira & Virgili, Univ Hosp Joan XXIII Tarragona, Gen Digest Surg Dept, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Caro, A (通讯作者)，Univ Rovira & Virgili, Univ Hosp Joan XXIII Tarragona, Gen Digest Surg Dept, Tarragona 43007, Spain.
EM dra5028@gmail.com
RI JimenezFranco, Andrea/PCR-9372-2025; Feliu, Francesc/ABF-5725-2021;
   Vicente, Vicente/L-6185-2019
OI Vicente, Vicente/0000-0002-4278-3264; Caro, Aleidis/0000-0001-6151-3879
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NR 23
TC 33
Z9 39
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 274
EP 279
DI 10.1111/j.1742-481X.2011.00782.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900011
PM 21410648
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Gdalevitch, P
   Afilalo, J
   Lee, C
AF Gdalevitch, Perry
   Afilalo, Jonathan
   Lee, Chen
TI Predictors of vacuum-assisted closure failure of sternotomy wounds
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Sternal wound; Sternotomy wound infection; Sternal wound complications;
   Sternal wound reconstruction; Vacuum-assisted closure (VAC);
   Mediastinitis
ID CARDIAC-SURGERY; MEDIASTINITIS; BRIDGE
AB Purpose: Vacuum-assisted closure (VAC) is a minimally invasive alternative to a muscle flap for closure of sternotomy wounds. The purpose of this study is to evaluate clinical predictors of VAC therapy failure in order to predict which patients would benefit from this approach.
   Methods: A retrospective cohort study of all patients with VAC management of sternotomy wounds between January 1997 and July 2003 was conducted. In this study, 37 patients had VAC management of their wounds post-cardiac surgery. Prior to data collection, 12 risk factors for impaired wound healing were identified. Information was obtained from patient charts and laboratory values.
   Results: Eight of the 36 patients failed the VAC therapy. Of the 12 variables studied, three were found to be predictive of VAC outcome. Bacteraemic patients had a higher failure rate as compared to patients with negative blood cultures (p <= 0.01). Patients with wound depth >= 4 cm also had a greater occurrence of VAC failure (p <= 0.01). Finally, VAC failure was significantly higher in patients who had a high degree of bony exposure and sternal instability (BESI, p <= 0.03). Patient characteristics and co-morbidities traditionally associated with impaired wound healing did not appear to worsen outcome with VAC.
   Conclusion: Patients who have positive blood cultures, wound depth >= 4 cm or a high degree of BESI tend to have worse outcomes with VAC and may be better managed by a surgical approach. Otherwise, VAC may be a reasonable option even in patients with high risks of impaired wound healing. Prospective randomised studies are needed to validate these hypotheses. Crown Copyright (C) 2008 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.
C1 [Gdalevitch, Perry; Lee, Chen] Univ Montreal, Dept Plast & Reconstruct Surg, Montreal, PQ, Canada.
   [Afilalo, Jonathan] McGill Univ, Dept Plast & Reconstruct Surg, Montreal, PQ, Canada.
C3 Universite de Montreal; McGill University
RP Gdalevitch, P (通讯作者)，12 Armstrong, Montreal, PQ H9G 2J7, Canada.
EM perritwin@hotmail.com
RI Afilalo, Jonathan/AEP-0841-2022
CR Anthony S., 1997, HARRISONS PRINCIPLES
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NR 12
TC 20
Z9 22
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2010
VL 63
IS 1
BP 180
EP 183
DI 10.1016/j.bjps.2008.08.020
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536YA
UT WOS:000273078600029
PM 19028156
DA 2026-07-24
ER

PT J
AU Frazee, R
   Manning, A
   Abernathy, S
   Isbell, C
   Isbell, T
   Kurek, S
   Regner, J
   Smith, R
   Papaconstantinou, H
AF Frazee, Richard
   Manning, Anthony
   Abernathy, Stephen
   Isbell, Claire
   Isbell, Travis
   Kurek, Stanley
   Regner, Justin
   Smith, Randall
   Papaconstantinou, Harry
TI Open vs Closed Negative Pressure Wound Therapy for Contaminated and
   Dirty Surgical Wounds: A Prospective Randomized Comparison
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 129th Annual Meeting of the Southern-Surgical-Association
CY DEC, 2017
CL Hot Springs, VA
SP So Surg Assoc
ID VACUUM-ASSISTED CLOSURE; OPEN COLORECTAL SURGERY; SITE INFECTION;
   LAPAROTOMY WOUNDS; CONTROLLED-TRIAL; MANAGEMENT; COSTS; EXPERIENCE;
   INCISIONS; SYSTEM
AB BACKGROUND: A new proprietary negative pressure wound device has been developed to apply negative pressure therapy to closed wounds (closed-NPWT). We postulated that closed-NPWT management of contaminated and dirty wounds would lead to faster wound healing and no significant difference in wound complications.
   STUDY DESIGN: An IRB approved, prospective randomized trial was performed. Patients were consented pre-operatively, but not entered nor assigned treatment until intraoperative findings were known. Patients were randomly assigned to either open-NPWT or a wound closed with skin staples and external closed-NPWT. Primary outcome was time to complete wound healing, defined as complete epithelization of the wound. Secondary outcomes were wound complications including wound infection, seroma, and dehiscence. Statistical analysis was performed using chi-square test, Fisher exact test, t-test, and Wilcoxon Rank-Sum test with significance of p < 0.05.
   RESULTS: Twenty-five closed-NPWT and 24 open-NPWT patients were analyzed. There were no significant differences in sex, mean age, BMI, smoking history, steroid use, comorbidities, or indication for surgery in the 2 groups. One patient in the open-NPWT group and 2 patients in the closed-NPWT group developed a wound infection (p = 1.0). Four open-NPWT and 3 closed-NPWT patients died from complications unrelated to the wound. Wound healing occurred at a median of 48 days (range 6 to 126 days) for the open-NPWT group vs a median of 7 days (range 6 to 12 days) for the closed-NPWT group (p < 0.0001).
   CONCLUSIONS: Wound healing was significantly faster in contaminated and dirty wounds when managed with closed-NPWT. There was no difference in wound complications between the 2 treatment groups. This approach shows promise for closed management of contaminated and dirty wounds and warrants additional prospective studies with larger patient groups. (C) 2017 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.
C1 [Frazee, Richard; Manning, Anthony; Abernathy, Stephen; Isbell, Claire; Isbell, Travis; Kurek, Stanley; Regner, Justin; Smith, Randall; Papaconstantinou, Harry] Baylor Scott & White Healthcare, Dept Surg, Div Trauma & Acute Care Surg, Temple, TX USA.
C3 Baylor Scott & White Health
RP Frazee, R (通讯作者)，Scott & White Healthcare, Texas A&M Hlth Sci Ctr, Coll Med, Trauma & Acute Care Surg, 2401 South 31st St, Temple, TX 76502 USA.
EM Rfrazee@sw.org
RI ; Papaconstantinou, Harry/HTM-6474-2023
OI Kurek, Stanley/0000-0001-6608-5404; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Zimlichman E, 2013, JAMA INTERN MED, V173, P2039, DOI 10.1001/jamainternmed.2013.9763
NR 22
TC 40
Z9 49
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD APR
PY 2018
VL 226
IS 4
BP 507
EP 512
DI 10.1016/j.jamcollsurg.2017.12.008
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GA4KM
UT WOS:000428298600024
PM 29274840
DA 2026-07-24
ER

PT J
AU Schröder, TA
   Karasavvas, A
   Bauckloh, M
   Schulz, MC
   Lauer, G
   Kroschwald, LM
AF Schroeder, Tom Alexander
   Karasavvas, Athanasios
   Bauckloh, Maximilian
   Schulz, Matthias C.
   Lauer, Guenter
   Kroschwald, Lysann Michaela
TI Influence of Unidirectional Vacuum Application on Bone Healing in
   Maxillofacial Surgery
SO CELLS
LA English
DT Article
DE VAC; NPWT; bone healing; regeneration; maxillofacial surgery
ID PRESSURE WOUND THERAPY; FIBROBLAST GROWTH FACTOR-2; ASSISTED CLOSURE;
   SOFT; DIFFERENTIATION; REGENERATION; MECHANISMS; INCREASES; PATHWAYS;
   INJURY
AB Negative-pressure wound therapy (NPWT) using vacuum-assisted closure (VAC) is a well known tissue defect bridging method that applies a vacuum pump to sterile, open-cell foam dressings via suction tubes. Although it has mostly been described for soft tissue use, there are also a few studies concerning its use on hard tissue. However, as oral and maxillofacial surgery has to deal with both soft and hard tissue, which lie next to each other in these regions, there is a particular need to assess the influence of negative pressure on bone. Therefore, the effects of different negative pressure levels (530 mbar and 725 mbar) and atmospheric pressure (1013 mbar) on bone tissue cultures and osteoblast cell cultures were investigated over periods of 1, 3, and 6 weeks. During the culture period, osteoblast growth and the tissue regeneration of bone defects were studied in vitro using tissue cultures that were histologically supplemented by cytological investigations and quantitative RNA expression studies. In the bone defect model, there was a faster defect reduction using NPWT; the effect was especially strong for 530 mbar. Compared to the control group, up to 30% more newly generated bone tissue was detected. This effect on the mineralization capacity was assessed by the mRNA expression of osteogenic marker genes, as well as the receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG), two multifaceted cytokines that regulate bone metabolism. The influence of negative pressure consequently resulted in a decreased RANKL/OPG ratio in osteoblasts. Associated with the upregulation of marker genes to up to 400%, including Col1, BMP4, OCN, and RUNX2, the decrease in the RANKL/OPG ratio to 41% indicates the stimulation of osteogenesis. Since VAC has been shown to be a safe and effective method to close wounds in general, these data suggest that patients suffering from compound bone and soft tissue defects in the maxillofacial area may benefit from an adapted therapy approach accelerating both soft and hard tissue regeneration.
C1 [Schroeder, Tom Alexander; Karasavvas, Athanasios; Bauckloh, Maximilian; Lauer, Guenter; Kroschwald, Lysann Michaela] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Oral & Maxillofacial Surg, Fetscherstr 74, D-01307 Dresden, Germany.
   [Schulz, Matthias C.] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Oral & Maxillofacial Surg, Osianderstr 2-8, D-72076 Tubingen, Germany.
   [Kroschwald, Lysann Michaela] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Translat Bone Joint & Soft Tissue Res, Fetscherstr 74, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital; Technische Universitat Dresden; Carl
   Gustav Carus University Hospital
RP Kroschwald, LM (通讯作者)，Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Oral & Maxillofacial Surg, Fetscherstr 74, D-01307 Dresden, Germany.; Kroschwald, LM (通讯作者)，Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Ctr Translat Bone Joint & Soft Tissue Res, Fetscherstr 74, D-01307 Dresden, Germany.
EM lysann.kroschwald@ukdd.de
RI ; Schröder, Tom Alexander/LXB-0402-2024
OI Kroschwald, Lysann Michaela/0000-0001-5381-9958; Schröder, Tom
   Alexander/0009-0001-9689-3020
FU Applicant program MeDDrive of the Medical Faculty Carl Gustav Carus of
   the TUD MedDriveGrant [60418]
FX This research was funded by the applicant program MeDDrive of the
   Medical Faculty Carl Gustav Carus of the TUD MedDriveGrant, grant number
   60418.
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NR 52
TC 0
Z9 0
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAY 21
PY 2025
VL 14
IS 10
AR 751
DI 10.3390/cells14100751
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3AH5N
UT WOS:001495570300001
PM 40422254
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Khan, SA
   Choudry, U
   Salim, A
   Nathani, KR
   Enam, SA
   Shehzad, N
AF Khan, Saad Akhtar
   Choudry, Usama
   Salim, Adnan
   Nathani, Karim Rizwan
   Enam, Syed Ather
   Shehzad, Noman
TI Current Management Trends for Surgical Site Infection After Posterior
   Lumbar Spinal Instrumentation: A Systematic Review
SO WORLD NEUROSURGERY
LA English
DT Review
DE Lumbar fusion; Surgical site infection; Spinal fusion; Spinal implants
ID THERAPY; FUSION; WOUNDS
AB OBJECTIVE: The objective of this systematic review is to determine the fate of spinal implants when patients develop postoperative wound infection after posterior instrumental fusion in a degenerative spine.
   METHODS: A systematic review of the English-language literature (published between January 2001 and July 2020) was undertaken to identify articles documenting the management strategy for surgical site infections (SSIs) after posterior lumbar spinal fusion. Studies on pedicle screw fixation after trauma, immunocompromised, metastatic spine disease, and combined anterior/posterior approach were excluded. Two independent reviewers assessed the level of evidence quality using the criteria set by the North American Spine Society, and disagreements were resolved by consensus.
   RESULTS: Of the 3071 citations identified, 49 met the criteria to undergo full-text review. Outcomes after SSIs were studied from a combined pool of 1150 patients who had undergone instrumental spinal fusion. The collected data showed that 456 patients (39.97%) had undergone spinal implant removal after SSI while 694 patients (60.03%) had their implants retained until the resolution of SSI. There was an absolute risk reduction (ARR) of 29% (-0.292) and a relative risk reduction (RRR) of 50.3% (-0.503) of implant removal if the patient underwent wound debridement following SSI. The number needed to treat (NNT) for wound debridement was calculated at 3.31 from our pooled cohort. The ARR in implant removal following vacuum-assisted closure (VAC) therapy was 16.6% and RRR was noted at 40.4%. This led to a high value of NNT at 6.0 patients. There was an ARR of 33.5% and a RRR of 70.7% was estimated in patients undergoing continuous irrigation.
   CONCLUSIONS: Our review of the literature suggests that surgeons prefer early wound debridement with or without negative pressure wound therapy under antimicrobial coverage for eradication of SSI after posterior lumbar spinal fusion. Implant removal is generally reserved for cases refractory to the other treatment modalities.
C1 [Khan, Saad Akhtar] Liaquat Natl Hosp, Dept Neurosurg, Karachi, Pakistan.
   [Choudry, Usama; Salim, Adnan; Nathani, Karim Rizwan; Enam, Syed Ather] Aga Khan Univ Hosp, Dept Neurosurg, Karachi, Pakistan.
   [Shehzad, Noman] Yorkshire & Humber Deanery, Dept Surg, York, England.
C3 Aga Khan University
RP Khan, SA (通讯作者)，Liaquat Natl Hosp, Dept Neurosurg, Karachi, Pakistan.
EM drsaadkhan84@gmail.com
RI ; Salim, Adnan/AAO-9806-2020
OI Nathani, Karim/0000-0003-4134-7011; Salim, Adnan/0000-0003-4185-673X
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NR 34
TC 9
Z9 12
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD AUG
PY 2022
VL 164
BP 374
EP 380
DI 10.1016/j.wneu.2022.05.138
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 5V3IE
UT WOS:000877125800009
PM 35671992
DA 2026-07-24
ER

PT J
AU Rottoli, M
   Di Simone, MP
   Vallicelli, C
   Vittori, L
   Liguori, G
   Boschi, L
   Poggioli, G
AF Rottoli, M.
   Di Simone, M. P.
   Vallicelli, C.
   Vittori, L.
   Liguori, G.
   Boschi, L.
   Poggioli, G.
TI Endoluminal vacuum-assisted therapy as treatment for anastomotic leak
   after ileal pouch-anal anastomosis: a pilot study
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Proctocolectomy, Restorative; Anastomosis, Surgical; Postoperative
   complications; Endosponge; Negative-pressure wound therapy
ID PROCTOCOLECTOMY; COMPLICATIONS; METAANALYSIS
AB Anastomotic leak after ileal pouch-anal anastomosis (IPAA) could lead to poor functional results and failure of the pouch. The aim of the present study was to analyze the outcomes of the vacuum-assisted closure therapy as the unique treatment for anastomotic leaks following IPAA without any additional surgical operations.
   Consecutive patients with anastomotic leak after IPAA treated at our institution between March 2016 and March 2017 were prospectively enrolled. After diagnosis, the Endosponge(A (R)) device was positioned in the gap and replaced until the cavity was reduced in size and covered by granulating tissue. A pouchoscopy was performed every week for the first month and monthly subsequently. No additional procedures were performed.
   Eight patients were included in the study. The leak was diagnosed at a median of 14 (6-35) days after surgery. At the time of diagnosis, seven patients had a defunctioning ileostomy performed as routine at the time of pouch formation, while one patient was diagnosed after ileostomy closure and underwent emergency diversion ileostomy. The Endosponge(A (R)) treatment started after a median of 6.5 (1-158) days after the diagnosis of the leakage and was carried on for a median of 12 (3-42) days. The device was replaced a median of 3 (1-10) times. The median length of hospital stay after the first application of the treatment was 15.5 (6-48) days. The complete healing of the leak was documented in all patients, after a median of 60 (24-90) days from the first treatment. All patients but one had their ileostomy reversed at a median of 2.5 (1-6) months from the confirmation of the complete closure.
   Endosponge(A (R)) is effective as the only treatment after IPAA leak. Based on the results of our prospective pilot study, application of Endosponge(A (R)) should be the treatment of choice in selected pouch anastomotic leaks not requiring immediate surgery. These results will have to be confirmed by future prospective studies including a larger number of patients.
C1 [Rottoli, M.; Di Simone, M. P.; Vallicelli, C.; Vittori, L.; Liguori, G.; Boschi, L.; Poggioli, G.] Alma Mater Studiorum Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Surg Alimentary Tract, Via Massarenti 9, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Rottoli, M (通讯作者)，Alma Mater Studiorum Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Surg Alimentary Tract, Via Massarenti 9, I-40138 Bologna, Italy.
EM matteo.rottoli2@unibo.it
RI Vallicelli, Carlo/HJH-2906-2023; Rottoli, Matteo/AAC-7258-2022;
   poggioli, gilberto/AAC-7599-2022
OI Rottoli, Matteo/0000-0003-0278-4139; 
CR Breen EM, 1998, DIS COLON RECTUM, V41, P691, DOI 10.1007/BF02236254
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NR 14
TC 31
Z9 35
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD MAR
PY 2018
VL 22
IS 3
BP 223
EP 229
DI 10.1007/s10151-018-1762-9
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA GA1ED
UT WOS:000428057400008
PM 29502228
DA 2026-07-24
ER

PT J
AU Monsen, C
   Acosta, S
   Mani, K
   Wann-Hansson, C
AF Monsen, C.
   Acosta, S.
   Mani, K.
   Wann-Hansson, C.
TI A randomised study of NPWT closure versus alginate dressings in
   peri-vascular groin infections: quality of life, pain and cost
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative wound pressure therapy; groin infection; quality of life; pain;
   cost
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; TRIAL; GRAFT
AB Objective: The aim of this study was to compare the vacuum assisted wound closure (VAC) system (negative pressure wound therapy; NPWT) and alginate wound dressings in terms of quality of life (QoL), pain resource use and cost in patients with deep peri-vascular groin infection after vascular surgery.
   Method: Patients with deep peri-vascular groin infection (Szilagyi grade III) were included and randomised to NPWT or alginate therapy. EuroQol 5D (EQ-5D) and brief pain inventory (BPI) were used to evaluate QoL and pain, respectively. l
   Results: Wound healing time until complete skin epithelialisation was shorter in the NPWT (n=9) compared to the alginate group (n=7), median 57 and 104 days, respectively (p=0.026). No difference was recorded in QoL and pain between the groups at study start and the second assessment. QoL analysis within groups between time points, showed that patients in NPWT groups improved in EQ-5D domains, 'self-care' (p= 0.034), 'usual activities' (p=0.046); EQ-5D index value (p=0.046) and EQ-VAS (p=0.028). Patients in the NPWT group reported significantly less pain 'affecting their relations with other people' and 'sleep' between time points. The NPWT group had significantly fewer dressing changes compared to the alginate group (p<0.001). The median frequency of wound dressing changes outside hospital was 20 (IQR 6-29) in the NPWT group (n=9), compared to 48 (IQR 42-77) in the alginate group (n=8; p=0.004). The saved personnel time for wound care in the first week for the NPWT group, compared with the alginate group, was 4.5 hours per week per nurse. The total hospitalised care cost was 83-87% of the total cost in both groups.
   Conclusion: NPWT therapy in patients with deep peri-vascular groin infection can be regarded as the dominant strategy due to improved clinical outcome with equal cost and quality of life measures.
C1 [Monsen, C.; Acosta, S.] Skane Univ Hosp, Vasc Ctr Malmo Lund, Malmo, Sweden.
   [Mani, K.] Univ Uppsala Hosp, Inst Surg Sci, Uppsala, Sweden.
   [Wann-Hansson, C.] Malmo Univ, Dept Care Sci, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Uppsala University; Uppsala
   University Hospital; Malmo University
RP Monsen, C (通讯作者)，Skane Univ Hosp, Vasc Ctr Malmo Lund, Malmo, Sweden.
EM christina.monsen@skane.se
RI Acosta, Stefan/JAX-3225-2023; Kumlien, Christine/ISB-5443-2023; Mani,
   Kevin/MIP-6841-2025
OI Acosta, Stefan/0000-0002-3225-0798; Kumlien,
   Christine/0000-0002-1437-5060; 
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NR 26
TC 26
Z9 28
U1 0
U2 16
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
BP 252
EP 260
DI 10.12968/jowc.2015.24.6.252
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PK
UT WOS:000355765400003
PM 26075373
DA 2026-07-24
ER

PT J
AU Levine, JM
AF Levine, Jeffrey M.
TI Dakin's Solution: Past, Present, and Future
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Review
DE Dakin's solution; antisepsis; wound care; medical history;
   negative-pressure wound therapy
ID INFECTED WOUNDS
AB Dakin's solution has been used for almost a century. It is a dilute solution of sodium hypochlorite, which is commonly known as household bleach. When properly applied, it can kill pathogenic microorganisms with minimum cytotoxicity. This article reviews its history and discusses how evolving technology might pave the way for a new role for this antiseptic.
C1 Albert Einstein Coll Med, Ctr Adv Wound Care, Beth Israel Med Ctr, New York, NY USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Yeshiva University
RP Levine, JM (通讯作者)，Albert Einstein Coll Med, Ctr Adv Wound Care, Beth Israel Med Ctr, New York, NY USA.
CR Altunoluk B, 2012, FOURNIERS GANGRENE C
   [Anonymous], 1941, NY TIMES
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NR 32
TC 36
Z9 43
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD SEP
PY 2013
VL 26
IS 9
BP 410
EP 414
DI 10.1097/01.ASW.0000432051.59348.cd
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 299YQ
UT WOS:000330432000004
PM 23958873
DA 2026-07-24
ER

PT J
AU Greer, N
   Foman, NA
   MacDonald, R
   Dorrian, J
   Fitzgerald, P
   Rutks, I
   Wilt, TJ
AF Greer, Nancy
   Foman, Neal A.
   MacDonald, Roderick
   Dorrian, James
   Fitzgerald, Patrick
   Rutks, Indulis
   Wilt, Timothy J.
TI Advanced Wound Care Therapies for Nonhealing Diabetic, Venous, and
   Arterial Ulcers
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; PLATELET-RICH PLASMA; CHRONIC LEG ULCERS; FOOT ULCERS;
   DOUBLE-BLIND; GROWTH-FACTOR; CLINICAL-EVALUATION; HEALING RATE
AB Background: Nonhealing ulcers affect patient quality of life and impose a substantial financial burden on the health care system.
   Purpose: To systematically evaluate benefits and harms of advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers.
   Data Sources: MEDLINE (1995 to June 2013), the Cochrane Library, and reference lists.
   Study Selection: English-language randomized trials reporting ulcer healing or time to complete healing in adults with nonhealing ulcers treated with advanced therapies.
   Data Extraction: Study characteristics, outcomes, adverse events, study quality, and strength of evidence were extracted by trained researchers and confirmed by the principal investigator.
   Data Synthesis: For diabetic ulcers, 35 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with a biological skin equivalent (relative risk [RR], 1.58 [95% CI, 1.20 to 2.08]) and negative pressure wound therapy (RR, 1.49 [CI, 1.11 to 2.01]) compared with standard care and low-strength evidence for platelet-derived growth factors and silver cream compared with standard care. For venous ulcers, 20 trials (9 therapies) met eligibility criteria. There was moderate-strength evidence for improved healing with keratinocyte therapy (RR, 1.57 [CI, 1.16 to 2.11]) compared with standard care and low-strength evidence for biological dressing and a biological skin equivalent compared with standard care. One small trial of arterial ulcers reported improved healing with a biological skin equivalent compared with standard care. Overall, strength of evidence was low for ulcer healing and low or insufficient for time to complete healing.
   Limitations: Only studies of products approved by the U.S. Food and Drug Administration were reviewed. Studies were predominantly of fair or poor quality. Few trials compared 2 advanced therapies.
   Conclusion: Compared with standard care, some advanced wound care therapies may improve the proportion of ulcers healed and reduce time to healing, although evidence is limited.
C1 [Greer, Nancy] Minneapolis Vet Affairs Hlth Care Syst, Minneapolis, MN 55417 USA.
   Univ Minnesota, Minneapolis, MN USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Minneapolis VA Health Care System; University of Minnesota System;
   University of Minnesota Twin Cities
RP Greer, N (通讯作者)，Minneapolis Vet Affairs Hlth Care Syst, 1 Vet Dr,Mail Code 152, Minneapolis, MN 55417 USA.
EM nancy.greer@va.gov
RI Wilt, Timothy/R-5572-2017
FU Department of Veterans Affairs, Veterans Health Administration, Office
   of Research and Development, Quality Enhancement Research Initiative
FX This article is based on research conducted by the Minneapolis
   Evidence-based Synthesis Program and was supported by the Department of
   Veterans Affairs, Veterans Health Administration, Office of Research and
   Development, Quality Enhancement Research Initiative.
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NR 70
TC 133
Z9 152
U1 2
U2 39
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD OCT 15
PY 2013
VL 159
IS 8
BP 532
EP +
DI 10.7326/0003-4819-159-8-201310150-00006
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 249BH
UT WOS:000326751200016
PM 24126647
DA 2026-07-24
ER

PT J
AU Johnson, C
   Spitzer, M
   Berry, S
   Minton, J
AF Johnson, Connie
   Spitzer, Mandy
   Berry, Sophie
   Minton, Jonathan
TI Clinician decision-making for transitioning to single-use negative
   pressure wound therapy: analysis of real-world practice in an acute
   setting
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE acute care; chronic wounds; hard-to-heal wounds; negative pressure wound
   therapy; NPWT; single-use negative pressure wound therapy; wound; wound
   care; wound dressing; wound healing
ID CONSENSUS PANEL RECOMMENDATIONS; COMPENDIUM; BURDEN; IMPACT; CARE
AB Objective: Despite the widespread adoption of traditional negative pressure wound therapy (tNPWT) to improve clinical outcomes for hard-to-heal (chronic) wounds and the increasing availability of single-use systems that improve patient acceptability, there is limited evidence published about when to use each type of system to optimise treatment pathways. The aim of this retrospective case review was to evaluate those wounds transitioned from tNPWT to single-use NPWT (sNPWT) in a real-world, acute care setting and review clinical outcomes, thereby informing future practice approaches. Method: A retrospective chart review of the treatment pathway and clinical outcomes of all patients with wounds managed using NPWT presenting at a single, acute care hospital in the US from February 2023 to September 2024 was conducted. Initial tNPWT was administered continually at either-80mmHg or-120mmHg for all wounds. Wound characteristics and healing outcomes for patients transitioned from tNPWT to sNPWT during the course of treatment were reviewed. Results: Electronic medical records of 27 patients (12 females, 15 males; with 70% aged 36-75 years) with wounds that were eligible for treatment with NPWT were available for review. Mean duration of tNPWT and sNPWT was 9.8 +/- 11.1 days (median: 7 days; range:3-60 days). Estimated daily mean wound area reduction was 5.8% (median value: 3.2%) with similar improvements noted for wound volume. Of the 27 wounds treated with tNPWT, eight were successfully transitioned to sNPWT once a sustained healing trajectory had been achieved. No wounds received first-line treatment with sNPWT, despite many of the wounds potentially being suitable for this approach. Conclusion: Approximately 30% of wounds included in this review were considered eligible for transition from tNPWT to sNPWT, facilitating earlier hospital discharge without compromising clinical outcomes. More widespread adoption of sNPWT, and even first-line use for appropriate wounds, may help to reduce hospital stay while maintaining effective wound management, thereby improving the patient experience, hospital efficiency and resource utilisation. Declaration of interest: Smith+Nephew, UK, provided funding to enable CJ to collect real-world data on the standard of care use of the NPWT systems used and Smith+Nephew provided support with statistical analysis of the results. Smith+Nephew had no role in patient management or clinical decision-making. CJ received a fee from Smith+Nephew to review and publish the clinical cases. SB, MS and JM are Smith+Nephew employees.
C1 [Johnson, Connie] Penn Med, Princeton Med Ctr, Plainsboro, NJ USA.
   [Spitzer, Mandy; Berry, Sophie] Smith Nephew, Global Clin Strategy, Global Clin & Med Affairs, Watford, England.
   [Minton, Jonathan] Smith Nephew, Global Clin & Med Affairs, Global Biostat, Watford, England.
C3 University of Pennsylvania; Pennsylvania Medicine
RP Berry, S (通讯作者)，Smith Nephew, Global Clin Strategy, Global Clin & Med Affairs, Watford, England.
EM sophie.berry@smith-nephew.com
CR Agency for Healthcare Research and Quality, 2021, AHRQ PUBLICATION, V21-EHC015
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2026
VL 35
IS 5
BP 400
EP 408
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HO6KM
UT WOS:001759018800001
PM 42060505
DA 2026-07-24
ER

PT J
AU Gutwein, LG
   Panigrahi, M
   Schultz, GS
   Mast, BA
AF Gutwein, Luke G.
   Panigrahi, Mousumee
   Schultz, Gregory S.
   Mast, Bruce A.
TI Microbial Barriers
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
DE Barrier therapy; Wound healing; Biofilms; Acute wounds; Chronic wounds
ID VACUUM-ASSISTED CLOSURE; CONTAINING WOUND DRESSINGS; ANTIMICROBIAL
   EFFICACY; 2-OCTYL CYANOACRYLATE; SUBATMOSPHERIC PRESSURE; SILVER
   SULFADIAZINE; BACTERIAL BIOFILM; SKIN CLOSURE; THERAPY;
   OCTYL-2-CYANOACRYLATE
AB Barrier wound therapy is commonplace in the health care environment and functions to limit bacterial colonization and infection in both acute wounds and recalcitrant chronic wounds. This article reviews the nature of acute and chronic wounds and their available adjunctive barrier therapies.
C1 [Gutwein, Luke G.; Panigrahi, Mousumee; Mast, Bruce A.] Univ Florida, Dept Surg, Div Plast & Reconstruct Surg, Gainesville, FL 32610 USA.
   [Schultz, Gregory S.] Univ Florida, Inst Wound Res, Dept Obstet & Gynecol, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Mast, BA (通讯作者)，Univ Florida, Dept Surg, Div Plast & Reconstruct Surg, POB 100286,1600 SW Archer Rd, Gainesville, FL 32610 USA.
EM Bruce.Mast@surgery.ufl.edu
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NR 66
TC 11
Z9 11
U1 0
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD JUL
PY 2012
VL 39
IS 3
BP 229
EP +
DI 10.1016/j.cps.2012.04.002
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 980CN
UT WOS:000306871300003
PM 22732372
DA 2026-07-24
ER

PT J
AU Arai, M
   Kushimoto, S
   Kim, S
   Masuno, T
   Hagiwara, J
   Ishii, H
   Yokota, H
AF Arai, Masatoku
   Kushimoto, Shigeki
   Kim, Shiei
   Masuno, Tomohiko
   Hagiwara, Jun
   Ishii, Hiromoto
   Yokota, Hiroyuki
TI A novel technique for managing open abdomen with the combined use of
   mesh-mediated traction and the bilateral anterior rectus abdominis
   sheath turnover flap method: how to do it
SO SURGERY TODAY
LA English
DT Article
DE Bilateral anterior rectus abdominis sheath turnover flap method;
   Negative pressure wound therapy; Open abdomen
ID CLOSURE
AB Proper management of abdominal compartment syndrome and open abdomen is important for improving the survival of critically ill patients. However, in cases requiring a prolonged period of open abdomen, it is frequently difficult to perform definitive fascial closure due to lateralization of the abdominal musculature. We herein present a novel combined technique for managing open abdomen. A 74-year-old male with diffuse peritonitis was transferred to our department, after which a long period of open abdomen made it difficult to achieve fascial closure. Polypropylene mesh was sutured to the fascial edges to reduce the gap, which was then serially tightened under negative pressure wound therapy. However, since it was not possible to accomplish definitive fascial closure, abdominal closure was performed using the bilateral anterior rectus abdominis sheath turnover flap method after removing the mesh, without any complications. This combined technique may be an effective alternative in patients requiring open abdomen with subsequent difficulty in achieving definitive fascial closure.
C1 [Arai, Masatoku; Kim, Shiei; Masuno, Tomohiko; Hagiwara, Jun; Ishii, Hiromoto; Yokota, Hiroyuki] Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, Tokyo 1138603, Japan.
   [Kushimoto, Shigeki] Tohoku Univ, Grad Sch Med, Div Emergency & Crit Care Med, Aoba Ku, Sendai, Miyagi 9808574, Japan.
C3 Nippon Medical School; Tohoku University
RP Arai, M (通讯作者)，Nippon Med Sch, Dept Emergency & Crit Care Med, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM amasatoku@nms.ac.jp
RI Kushimoto, Shigeki/AET-6785-2022
FU Grants-in-Aid for Scientific Research [25462836] Funding Source: KAKEN
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Breuing K, 2010, SURGERY, V148, P544, DOI 10.1016/j.surg.2010.01.008
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Kushimoto S, 2007, WORLD J SURG, V31, P2, DOI 10.1007/s00268-006-0282-3
   Miyamoto Y, 2015, SURG TODAY, V45, P121, DOI 10.1007/s00595-014-0936-y
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
NR 8
TC 4
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD OCT
PY 2015
VL 45
IS 10
BP 1335
EP 1339
DI 10.1007/s00595-015-1133-3
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CR1GM
UT WOS:000361072900020
PM 25708720
DA 2026-07-24
ER

PT J
AU Rhee, SM
   Valle, MF
   Wilson, LM
   Lazarus, G
   Zenilman, JM
   Robinson, KA
AF Rhee, Susan M.
   Valle, M. Frances
   Wilson, Lisa M.
   Lazarus, Gerald
   Zenilman, Jonathan M.
   Robinson, Karen A.
TI Negative pressure wound therapy technologies for chronic wound care in
   the home setting: A systematic review
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID EXTRACELLULAR-MATRIX; DERMAL FIBROBLASTS; SKIN; REPAIR; ANGIOGENESIS;
   CONTRACTION; ELASTICITY; EXPRESSION; SCAFFOLDS; RESPONSES
AB The use of negative pressure wound therapy (NPWT) is increasing in both the inpatient and outpatient settings. We conducted a systematic review on the efficacy and safety of NPWT for the treatment of chronic wounds in the home setting. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and the Cumulative Index to Nursing and Allied Health Literature, up to June 2014. Two independent reviewers screened search results. Seven studies met our criteria for inclusion. Six of the studies compared NPWT devices to other wound care methods and one study compared two different NPWT technologies. Data were limited by variability in the types of comparator groups, methodological limitations, and poor reporting of outcomes. We were unable to draw conclusions about the efficacy or safety of NPWT for the treatment of chronic wounds in the home setting due to the insufficient evidence. Consensus is needed on the methods of conducting and reporting wound care research so that future studies are able inform decisions about the use of NPWT in the home environment for chronic wounds.
C1 [Rhee, Susan M.; Zenilman, Jonathan M.] Johns Hopkins Univ, Div Infect Dis, Sch Med, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21218 USA.
   [Valle, M. Frances] Univ Maryland, Sch Nursing, Dept Org Syst & Adult Hlth, College Pk, MD USA.
   [Wilson, Lisa M.] Johns Hopkins Univ Bloomberg, Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA.
   [Lazarus, Gerald] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21218 USA.
   [Robinson, Karen A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; University System of
   Maryland; University of Maryland College Park; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Johns Hopkins
   University; Johns Hopkins University
RP Robinson, KA (通讯作者)，1830 E Monument St,Suite 8068, Baltimore, MD USA.
EM krobin@jhmi.edu
RI ; Robinson, Karen/OWA-0447-2025
OI Rhee, Susan/0009-0002-3350-2245; 
FU PHS HHS [HHS 290-201-20007-I] Funding Source: Medline
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   Witte MB, 1998, SURGERY, V124, P464, DOI 10.1067/msy.1998.90578
NR 43
TC 8
Z9 11
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2015
VL 23
IS 4
BP 506
EP 517
DI 10.1111/wrr.12295
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CQ7EG
UT WOS:000360765100174
PM 25845268
DA 2026-07-24
ER

PT J
AU Chalupa, R
AF Chalupa, Robyn
TI Can an NP in orthopedics improve trauma care outcomes?
SO JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS
LA English
DT Editorial Material
AB The authors analyzed the effect of an NP in orthopedic trauma on length of stay and cost in a level I trauma center. A retrospective chart review of all patients discharged from the orthopedic surgery service 1 year before the addition of an NP and 1 year after the hiring of an NP was undertaken. Chart review included age, sex, length of stay, discharge destination, IV antibiotic use, negative-pressure wound therapy, admission location, and length of time to surgery. The hiring of an NP yielded a statistically significant decrease in length of stay across the following patient subgroups: patients transferred from the trauma service (13.56 compared with 7.02 days), patients age 60 years and older (7.34 compared with 5.04 days), patients discharged to a rehabilitation facility (10.84 compared with 8.31 days), and patients discharged on antibiotics/negative-pressure wound therapy (15.16 compared with 11.24 days). Length of time to surgery was also decreased (1.48 compared with 1.31 days). The addition of a dedicated NP in orthopedic trauma at a county level I trauma center resulted in a statistically signifi cant decrease in length of stay and thus reduced indirect costs to the hospital.
CR Hiza EA, 2015, J ORTHOP TRAUMA, V29, pe225, DOI 10.1097/BOT.0000000000000261
NR 1
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1547-1896
EI 0893-7400
J9 JAAPA-J AM ACAD PHYS
JI JAAPA-J. Am. Acad. Physician Assist.
PD MAY
PY 2017
VL 30
IS 5
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EW4RM
UT WOS:000402488600008
DA 2026-07-24
ER

PT J
AU Indolfi, C
   Passafaro, F
   Mongiardo, A
   Spaccarotella, C
   Torella, D
   Sorrentino, S
   Polimeni, A
   Emanuele, V
   Curcio, A
   De Rosa, S
AF Indolfi, Ciro
   Passafaro, Francesco
   Mongiardo, Annalisa
   Spaccarotella, Carmen
   Torella, Daniele
   Sorrentino, Sabato
   Polimeni, Alberto
   Emanuele, Vittorio
   Curcio, Antonio
   De Rosa, Salvatore
TI Delayed Sudden Radial Artery Rupture After Left Transradial Coronary
   Catheterization A Case Report
SO MEDICINE
LA English
DT Article
AB Local complications at the radial access site are not frequent, hence its large diffusion as the preferred access route for endovascular procedures. However, in a time of fast widespreading, better comprehension of all potential complications becomes critical to facilitate their early recognition and the most appropriate treatment.
   In this case report, we present for the first time a case of sudden massive bleeding at the left wrist, due to spontaneous gross rupture of the left radial artery bleeding 15 days after an endovascular procedure through a left radial arterial access. The patient had been readmitted to the hospital after evidence of local infection at the left wrist with loss of substance. The radial artery was patent with no evidence of pseudoaneurysm.
   After sudden radial artery rupture, with massive bleeding and suspicion that the local infection could have reached the arterial wall, surgical hemostasis with artery ligation was obtained. Healing of the large wound was then efficiently speeded up using a negative pressure wound therapy.
   This is the first case of macroscopic radial artery rupture associated with local wrist infection after arterial catheterization. After prompt surgical hemostasis, negative pressure wound therapy was very helpful in favoring healing of the large and deep wound.
C1 [Indolfi, Ciro; Passafaro, Francesco; Mongiardo, Annalisa; Spaccarotella, Carmen; Torella, Daniele; Sorrentino, Sabato; Polimeni, Alberto; Emanuele, Vittorio; Curcio, Antonio; De Rosa, Salvatore] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Div Cardiol, I-88100 Catanzaro, Italy.
   [Indolfi, Ciro] CNR, Dept Med, URT CNR, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Consiglio Nazionale delle
   Ricerche (CNR)
RP Indolfi, C (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy.
EM indolfi@unicz.it
RI Sorrentino, Sabato/D-3297-2019; De Rosa, Salvatore/J-6350-2012;
   Spaccarotella, CARMEN ANNA MARIA/IAS-0433-2023; Polimeni,
   Alberto/M-9243-2019; Curcio, Antonio/JZT-5160-2024; TORELLA,
   Daniele/A-3296-2009
OI Sorrentino, Sabato/0000-0002-8316-7134; De Rosa,
   Salvatore/0000-0001-5388-942X; Spaccarotella, CARMEN ANNA
   MARIA/0000-0003-1825-0510; Mongiardo, Annalisa/0009-0001-5364-7479;
   Polimeni, Alberto/0000-0002-9166-3031; Curcio,
   Antonio/0000-0003-3213-4436; TORELLA, Daniele/0000-0002-4915-5084;
   INDOLFI, Ciro/0000-0003-1241-6487
CR Basili S, 2014, CIRC-CARDIOVASC INTE, V7, P577, DOI 10.1161/CIRCINTERVENTIONS.113.001197
   Dandekar VK, 2012, CARDIOVASC REVASCULA, V13, P39, DOI 10.1016/j.carrev.2011.08.005
   De Rosa S, 2014, JACC-CARDIOVASC INTE, V7, pE89, DOI 10.1016/j.jcin.2013.11.028
   De Rosa S, 2014, INT J CARDIOL, V171, P66, DOI 10.1016/j.ijcard.2013.11.046
   Hamon M, 2013, EUROINTERVENTION, V8, P1242, DOI 10.4244/EIJV8I11A192
   Lehmann R, 2011, J INTERV CARDIOL, V24, P56, DOI 10.1111/j.1540-8183.2010.00603.x
   Nagelschmitz J, 2014, CLIN PHARMACOL-ADV A, V6, P51, DOI 10.2147/CPAA.S47895
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   Xhepa E, 2014, EUROINTERVENTION, V10, P198, DOI 10.4244/EIJV10I2A33
NR 9
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR
PY 2015
VL 94
IS 10
AR e634
DI 10.1097/MD.0000000000000634
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CD3SP
UT WOS:000351001300022
PM 25761194
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Feng, MX
   Gadkaree, SK
   Derakhshan, A
AF Feng, Max
   Gadkaree, Shekhar K.
   Derakhshan, Adeeb
TI Vacuum assisted therapy in the head and neck
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Article
DE chronic wounds; fistula; head and neck; Negative pressure wound therapy;
   vacuum assisted therapy
ID PRESSURE WOUND THERAPY; CLOSURE; MANAGEMENT; RECONSTRUCTION; FISTULA
AB Purpose of reviewTo review the utility of negative pressure wound therapy (NPWT) in the management of head and neck wounds.Recent findingsNPWT has broad applications in the management of head and neck wounds. NPWT has demonstrated success in the treatment of head and neck fistulas and necrotizing soft tissue infections. Immediate application after free flap reconstruction is also shown to be safe, with benefits of reduced tissue edema and promotion of wound healing. NPWT can further be used to prepare chronic wounds for reconstruction, particularly in patients who have undergone radiotherapy. The addition of intermittent saline instillation and dwell time has shown promise in treating head and neck fistulas.SummaryNPWT has been shown to improve wound healing times, reduce length of hospital stays, decrease frequency of dressing changes, and lower pain scores compared to conventional wound care. However, existing evidence is largely limited to case reports and retrospective studies, with few prospective comparative studies. Larger prospective studies are needed to further investigate the efficacy and safety of NPWT in the head and neck.
C1 [Feng, Max; Derakhshan, Adeeb] Loma Linda Univ Hlth, Dept Otolaryngol Head & Neck Surg, Loma Linda, CA USA.
   [Gadkaree, Shekhar K.] Univ Miami, Miller Sch Med, Dept Otolaryngol Head & Neck Surg, Miami, FL USA.
   [Derakhshan, Adeeb] Loma Linda Univ Hlth, Dept Otolaryngol Head & Neck Surg, Div Facial Plast & Reconstruct Surg, Loma Linda, CA USA.
C3 Loma Linda University; University of Miami; Loma Linda University
RP Derakhshan, A (通讯作者)，Loma Linda Univ, Med Ctr, 11234 Anderson St, Loma Linda, CA 92354 USA.
EM adeeb.derakhshan@gmail.com
OI Feng, Max/0000-0002-7042-6213
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NR 47
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD AUG
PY 2025
VL 33
IS 4
BP 230
EP 235
DI 10.1097/MOO.0000000000001057
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 4NH5L
UT WOS:001522085000003
PM 40402849
DA 2026-07-24
ER

PT J
AU Wertenauer, A
   Gräber, S
   Müller, CSL
AF Wertenauer, A.
   Graeber, S.
   Mueller, C. S. L.
TI Retrospective 8-year analysis of negative pressure wound therapy in
   dermatosurgery: a single-centre experience
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID INSTILLATION; RECOMMENDATIONS
AB Background Negative pressure wound therapy (NPWT) is an established treatment modality in dermatologic surgery, but proof of evidence for efficacy is inconclusive.
   Purpose To evaluate patient characteristics, treatment modalities and outcomes in a single dermatosurgery centre with NPWT applied over chronic and acute surgical wounds.
   Methods Of all surgical patients between 2008 and 2015, we selected those who were treated and hospitalized due to NPWT for treatment of acute and chronic wounds. The medical records of 188 patients were retrospectively evaluated and statistically calculated.
   Results Method of surgical defect closure depends significantly on localization of the surgical defect, cardiovascular comorbidity and age. Hence, outcome depends significantly on the surgical situation that indexes NPWT, the underlying diagnosis and the vacuum system used, but is not associated with distinct treatment modalities or gender of the patients. Hospitalization significantly depends on the vacuum system used, surgical situation that indexes NPWT and underlying diagnoses.
   Conclusion NPWT has a fixed role in distinct, well-defined clinical indications in dermatosurgery as the treatment of acute surgical wounds, fixation of skin grafts and treatment of skin substitutes, as well as an important treatment option for refractory, superinfected chronic wounds in dermatologic patients.
C1 [Wertenauer, A.; Mueller, C. S. L.] Saarland Univ, Med Ctr, Dept Dermatol, Homburg, Germany.
   [Graeber, S.] Saarland Univ, Med Ctr, Inst Biometry Epidemiol & Med Informat, Homburg, Saarland, Germany.
C3 Universitatsklinikum des Saarlandes; Universitatsklinikum des Saarlandes
RP Müller, CSL (通讯作者)，Saarland Univ, Med Ctr, Dept Dermatol, Homburg, Germany.
EM cornelia.mueller@uks.eu
OI Müller, Cornelia/0000-0002-7656-721X
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NR 15
TC 2
Z9 2
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD JAN
PY 2018
VL 32
IS 1
BP 102
EP 107
DI 10.1111/jdv.14572
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FS9WZ
UT WOS:000422771300043
PM 28859231
DA 2026-07-24
ER

PT J
AU McNulty, AK
   Schmidt, M
   Feeley, T
   Villanueva, P
   Kieswetter, K
AF McNulty, Amy K.
   Schmidt, Marisa
   Feeley, Teri
   Villanueva, Patricia
   Kieswetter, Kris
TI Effects of negative pressure wound therapy on cellular energetics in
   fibroblasts grown in a provisional wound (fibrin) matrix
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID FACTOR-BB; MULTICENTER; LACTATE; CLOSURE
AB Negative pressure wound therapy (NPWT) using reticulated open cell foam dressing (ROCF) is effective for treatment of recalcitrant wounds; however, the effects of this therapy on cellular metabolism remain to be elucidated. The effect of two different subatmospheric pressure applications on the cell energetics of human fibroblasts grown in a 3D fibrin matrix was studied using two different pressure-manifolding materials, an ROCF or gauze under suction (GUS). It was found that levels of cytochrome c oxidase, energy charge, and adenosine triphosphate/adenosine diphosphate were significantly increased following the application of NPWT using ROCF vs. GUS (p < 0.05). Increases in these parameters likely reflect an improved energetic status. In addition, levels of transforming growth factor-beta and platelet-derived growth factor (alpha and beta isoforms) were significantly increased ( 80 and 53%, respectively; p < 0.05) over static control cultures following treatment with NPWT using ROCF but not following GUS. These growth factors are known to be important during wound healing. Clearly, both the material used as the dressing to manifold the subatmospheric pressure and the pressure used have a dramatic effect on cellular response.
C1 [McNulty, Amy K.; Schmidt, Marisa; Feeley, Teri; Villanueva, Patricia; Kieswetter, Kris] Kinet Concepts Inc, Res & Dev, San Antonio, TX 78249 USA.
RP McNulty, AK (通讯作者)，Kinet Concepts Inc, Res & Dev, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM amy.mcnulty@kci1.com
FU Kinetic Concepts International
FX Funding was provided by Kinetic Concepts International.
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NR 33
TC 66
Z9 80
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2009
VL 17
IS 2
BP 192
EP 199
DI 10.1111/j.1524-475X.2009.00460.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 418ZJ
UT WOS:000264188600007
PM 19320887
DA 2026-07-24
ER

PT J
AU Jeyapalina, S
   Mitchell, SJ
   Agarwal, J
   Bachus, KN
AF Jeyapalina, Sujee
   Mitchell, Saranne J.
   Agarwal, Jayant
   Bachus, Kent N.
TI Biomimetic coatings and negative pressure wound therapy independently
   limit epithelial downgrowth around percutaneous devices
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID TRANSFEMORAL AMPUTATION; CONNECTIVE-TISSUE; FAILURE MODES; RGD PEPTIDES;
   SKIN BARRIER; ATTACHMENT; IMPLANTS; PROSTHESIS; REHABILITATION;
   INFECTION
AB Biomimetic material coatings and negative pressure wound therapy (NPWT) have been shown independently to limit the epithelial downgrowth rates in percutaneous devices. It was therefore hypothesized that these techniques, in combination, could further limit the clinically observed epithelial downgrowth around these devices. In this study, we evaluated the efficacy of two biomimetic coatings, collagen and hydroxyapatite (HA), to prevent downgrowth when used with continuous NPWT. Using an established single-stage surgical protocol, collagen (n=10) and HA (n=10) coated devices were implanted subdermally on the back of hairless guinea pigs. Five animals from each group were subjected to continuous similar to 90mmHg NPWT. Four weeks post-implantation, animals were sacrificed, and the devices and surrounding tissues were harvested, processed, and downgrowth was computed and compared to historical porous titanium coated controls. Data showed a significant reduction in downgrowth in NPWT treated animals (p0.05) when compared to the untreated porous titanium controls. HA coated devices, without the NPWT treatment, also showed significantly decreased downgrowth compared to the untreated porous titanium controls.
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C1 [Jeyapalina, Sujee; Mitchell, Saranne J.; Bachus, Kent N.] Dept Vet Affairs Med Ctr, Orthopaed Res Lab, Salt Lake City, UT 84148 USA.
   [Jeyapalina, Sujee; Agarwal, Jayant] Univ Utah, Sch Med, Dept Surg, Div Plast Surg, Salt Lake City, UT 84132 USA.
   [Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Orthopaed Ctr, Orthopaed Res Lab, Salt Lake City, UT 84108 USA.
   [Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
C3 US Department of Veterans Affairs; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Jeyapalina, S; Bachus, KN (通讯作者)，Dept Vet Affairs Med Ctr, Orthopaed Res Lab, Salt Lake City, UT 84148 USA.; Jeyapalina, S (通讯作者)，Univ Utah, Sch Med, Dept Surg, Div Plast Surg, Salt Lake City, UT 84132 USA.; Bachus, KN (通讯作者)，Univ Utah, Orthopaed Ctr, Orthopaed Res Lab, Salt Lake City, UT 84108 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM sujee.jeyapalina@hsc.utah.edu; kent.bachus@hsc.utah.edu
RI Bachus, Kent/KYO-7869-2024
OI Jeyapalina, Sujee/0000-0002-2199-7191; Mitchell, Saranne
   J/0000-0002-6473-7648
FU Department of Defense [W81XWH-11-1-0435]; United States Department of
   Veterans Affairs Rehabilitation Research and Development Service
   [I01RX001217]; Department of Orthopaedics, University of Utah School of
   Medicine, Salt Lake City, Utah
FX This work was supported in part by the Department of Defense
   [#W81XWH-11-1-0435, 2010], by the United States Department of Veterans
   Affairs Rehabilitation Research and Development Service under Merit
   Review Award [#I01RX001217, 2014], and by the Department of
   Orthopaedics, University of Utah School of Medicine, Salt Lake City,
   Utah. The views, opinions, and/or findings presented are those of the
   authors and should not be construed as an official position, policy or
   decision of any of these funding sources unless so designated by other
   documentation. In conducting research using animals, the investigators
   adhered to the Animal Welfare Act Regulations and other Federal statutes
   relating to animals and experiments involving animals and the principles
   set forth in the current version of the Guide for Care and Use of
   Laboratory Animals, National Research Council. The authors wish to
   express their sincere gratitude to Thortex Inc. (Portland, OR) for
   device fabrication and coating support. They also wish to acknowledge
   the Bone and Joint Research Laboratory's Histology Team for their
   technical expertize with the samples embedment process, and Greg
   Stoddard for his help with statistical analysis.
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NR 52
TC 7
Z9 8
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD JUN
PY 2019
VL 30
IS 6
AR 71
DI 10.1007/s10856-019-6272-4
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA IC5WN
UT WOS:000471039800001
PM 31183809
DA 2026-07-24
ER

PT J
AU Wu, MH
   Wu, HY
AF Wu, Ming-Ho
   Wu, Han-Yun
TI A Simple Device for Closure of a Colocutaneous Fistula within the
   Laparotomy Wound: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE colocutaneous fistula; esophageal carcinoma; esophageal reconstruction;
   laparotomy wound; nonsurgical management
ID ENTEROCUTANEOUS FISTULAS; OPEN ABDOMEN; MANAGEMENT
AB Colocutaneous fistulas within laparotomy wounds are rare and difficult to treat. Surgical repair may be contraindicated or not desired and negative pressure wound therapy may not be successful. A simple device made from a silicone, flexi-aid hand exerciser was used to close a colocutaneous fistula within the laparotomy wound of a 50-year old man following surgery of an esophageal carcinoma and a surgical history of Whipple's procedure for adenocarcinoma of the ampulla of Vater. His wound developed 9 days postoperatively, measured 8 cm x 3 cm x 2 cm, and was contaminated with fecal material. Initial efforts involving cleansing and the use of negative pressure wound therapy were unsuccessful and the patient refused additional surgery. In this patient, a silicone occlusion device, used in conjunction with a silver hydrofiber dressing, prevented fecal soiling and facilitated closure of the colocutaneous fistula and the laparotomy wound. He was discharged on postop day 22 and healed by postop day 64. This was the first time this approach was used. Studies to optimize nonsurgical management approaches of these complicated conditions are needed.
C1 [Wu, Ming-Ho; Wu, Han-Yun] Tainan Municipal Hosp, Dept Surg, Div Thorac Surg, Tainan, Taiwan.
RP Wu, MH (通讯作者)，670 Chung Te Rd, Tainan 701, Taiwan.
EM m2201@mail.ncku.edu.tw
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NR 10
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD OCT
PY 2009
VL 55
IS 10
BP 24
EP 26
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 517IN
UT WOS:000271606800007
PM 19864693
DA 2026-07-24
ER

PT J
AU Fagerdahl, AM
   Boström, L
   Ottosson, C
   Ulfvarson, J
AF Fagerdahl, Ann-Mari
   Bostrom, Lennart
   Ottosson, Carin
   Ulfvarson, Johanna
TI Patients' Experience of Advanced Wound Treatment-A Qualitative Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE advanced moist wound therapy; negative pressure wound therapy;
   qualitative research; quality of life; wound treatment
ID LEG ULCERS; GREEN FOAM; BLACK FOAM; OF-LIFE; THERAPY; GAUZE
AB Introduction. Each patient experiences wound treatment differently, and it is important to enhance the knowledge of the impact of the treatment to be able to individualize patient care. Methods. This descriptive qualitative study aims to describe the experience of patients with wounds treated with advanced moist wound therapy (AMWT) and negative pressure wound therapy (NPWT). Data were collected from 15 diaries written by patients during their treatment, and analyzed with content analysis. Results. The results identified an overall theme of "threat to normality," and 3 subcategories including "impact on daily life," "manageability," and "powerlessness." Conclusion. While there were many similarities in the descriptions of the patients in the 2 groups, there also were unique features for each treatment group. For patients treated with AMWT, the main concern was pain. For patients treated with NPWT, the main concern was the optimal functioning of the machine. Patients undergoing wound treatment have different focuses, concerns, and needs related to treatment modality. It is important for health care personnel to carry this in mind to be able to individualize patient care.
C1 [Fagerdahl, Ann-Mari; Bostrom, Lennart] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Surg, S-11883 Stockholm, Sweden.
   [Ottosson, Carin] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Dept Orthopaed Surg, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Nursing, S-11883 Stockholm, Sweden.
C3 Sodersjukhuset Hospital; Karolinska Institutet; Karolinska Institutet;
   Sodersjukhuset Hospital; Karolinska Institutet
RP Fagerdahl, AM (通讯作者)，Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.
EM ann-mari.fagerdahl@sodersjukhuset.se
OI Fagerdahl, Ami/0000-0002-9170-581X
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NR 22
TC 13
Z9 14
U1 0
U2 13
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2013
VL 25
IS 8
BP 205
EP 211
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Surgery
GA 212WW
UT WOS:000324014500004
PM 25867129
DA 2026-07-24
ER

PT J
AU Wang, RF
   Yu, JB
   Guan, YB
   Xu, XS
   Cai, XS
AF Wang, Ruofan
   Yu, Jiongbiao
   Guan, Yubin
   Xu, Xiaosong
   Cai, Xiangsheng
TI Pseudomonas oryzihabitans: An Emerging Opportunistic Pathogen Causing
   Severe Burn Wound Infection After Improper Moxibustion Patch Use in an
   Elderly Diabetic Farmer
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE moxibustion patch; third-degree burn; Pseudomonas oryzihabitans;
   antimicrobial therapy; surgical debridement; negative pressure wound
   therapy; NPWT
AB Background: Pseudomonas oryzihabitans, a Gram-negative opportunistic pathogen, is associated with infected burn wounds in elderly patients with underlying diseases. Moxibustion patch-related deep burns in farmers (due to occupational exposure) often have nonspecific manifestations, causing diagnostic delays. This case highlights the synergistic role of microbiologically guided antimicrobial therapy and surgical intervention. Case Summary: A 71-year-old female farmer with type 2 diabetes and bilateral lower extremity arteriosclerotic occlusive disease developed left lower leg third-degree burn due to improper moxibustion patch use; wound infection occurred after self-treatment. Wound secretion culture confirmed Pseudomonas oryzihabitans (colony count >= 106 CFU/mL) sensitive to cefoperazone-sulbactam. She received microbiologically guided antimicrobial therapy combined with surgical debridement, negative pressure wound therapy (NPWT), and elective split-thickness skin grafting. Postoperatively, infection indicators decreased significantly, the wound healed well, and no recurrence or complications were observed. Conclusion: Elderly patients with underlying diseases are at high risk of such burns and infections. The synergistic application of microbiologically precise antimicrobial therapy and surgical intervention is key to improving efficacy and reducing recurrence.
C1 [Wang, Ruofan; Yu, Jiongbiao; Guan, Yubin; Xu, Xiaosong] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Clin Lab, Guangzhou, Peoples R China.
   [Cai, Xiangsheng] Guangzhou Eleventh Peoples Hosp, Guangzhou Cadre & Talent Hlth Management Ctr, Clin Lab, Guangzhou, Peoples R China.
C3 Guangdong Pharmaceutical University
RP Cai, XS (通讯作者)，Guangzhou Eleventh Peoples Hosp, Guangzhou Cadre & Talent Hlth Management Ctr, Clin Lab, Guangzhou, Peoples R China.
EM xiangshengcai@yeah.net
RI Cai, Xiangsheng/GPS-8610-2022
CR Behera S, 2025, TRIALS, V26, DOI 10.1186/s13063-025-08757-2
   Burgess M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11193073
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NR 16
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2026
VL 19
AR 611045
DI 10.2147/IDR.S611045
PG 8
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA JB7TR
UT WOS:001785564900001
PM 42261283
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU McGarrah, B
AF McGarrah, Barbara
TI Using Negative Pressure Therapy for Wound Healing in the Extremely
   Low-Birth-Weight Infant (Micropreemie)
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE low birth-weight infant; micropreemie; necrotizing enterocolitis (NEC);
   negative pressure wound therapy
ID PEDIATRIC WOUNDS
AB BACKGROUND: The term micropreemie describes an infant born weighing less than 1 pound 12 ounces (800 g) or before 26 weeks' gestation. The gastrointestinal tract of these premature infants is fragile due to developmental immaturity. In this case study, we describe our experience with wound care following surgical intervention for necrotizing enterocolitis in a micropreemie.
   CASE: Baby A is a female who was born at 23 weeks 5 days; she weighed 530 g. On day 12 of life, a sonogram was interpreted as suspicious for intestinal perforation. She underwent exploratory laparotomy with ileal perforation resection and stoma formation. A patch made from porcine small intestine submucosa was used to close the abdomen and negative pressure therapy using an open cell reticulated black foam was placed to assist with wound healing and decrease the need for frequent dressing changes.
   CONCLUSION: Our experience with this case demonstrates the feasibility of negative pressure wound therapy in selected micropreemie infants. Negative pressure therapy was effective in wound closure and decreased the number of dressing changes anticipated using conventional wound care.
C1 [McGarrah, Barbara] Texas Hlth Harris Methodist Ft Worth, Ft Worth, TX 76104 USA.
RP McGarrah, B (通讯作者)，Texas Hlth Harris Methodist Ft Worth, 1300 W Terrell, Ft Worth, TX 76104 USA.
EM mcgarrahba@charter.net
CR [Anonymous], 2006, Wounds UK, V2, P33
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NR 11
TC 5
Z9 6
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2015
VL 42
IS 4
BP 409
EP 412
DI 10.1097/WON.0000000000000139
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CM8KV
UT WOS:000357950600006
PM 26135829
DA 2026-07-24
ER

PT J
AU Tang, L
   Guo, ZY
   Zhao, Q
   Fan, X
   Pu, YJ
   He, B
   Chen, JL
AF Tang, Lei
   Guo, Zhaoyuan
   Zhao, Quan
   Fan, Xi
   Pu, Yuji
   He, Bin
   Chen, Jianlin
TI A Biodegradable Janus Sponge for Negative Pressure Wound Therapy
SO BIOMACROMOLECULES
LA English
DT Article
ID PEG-PLLA MICROPARTICLES; NPWT; SURGERY
AB Negative pressure wound therapy (NPWT) is effective in repairing serious skin injury. The dressing used in the NPWT is important for wound healing. In this paper, we develop biodegradable amphiphilic polyurethanes (PUs) and fabricate the PUs into sponges as wound dressings (Bi-@e) with Janus pore architectures for NPWT. The Bi-@e is adaptive to all the stages of the wound healing process. The Janus Bi-@e sponge consists of two layers: the dense hydrophobic upper layer with small pores provides protection and support during negative pressure drainage, and the loose hydrophilic lower layer with large pores absorbs large amounts of wound exudate and maintains a moist environment. Additionally, antibacterial agent silver sulfadiazine (SSD) is loaded into the sponge against Escherichia coli and Staphylococcus aureus with a concentration of 0.50 wt%. The Janus sponge exhibits a super absorbent capacity of 19.53 times its own water weight and remarkable resistance to compression. In a rat skin defect model, the Janus Bi-@e sponge not only prevents the conglutination between regenerative skin and dressing but also accelerates wound healing compared to commercially available NPWT dressing. The Janus Bi-@e sponge is a promising dressing for the NPWT.
C1 [Tang, Lei; Guo, Zhaoyuan; Zhao, Quan; Fan, Xi; Pu, Yuji; He, Bin] Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China.
   [Guo, Zhaoyuan] Ningbo Baoting Biotech Co Ltd, Ningbo 315010, Peoples R China.
   [Chen, Jianlin] Chengdu Med Coll, Sch Lab Med, Sichuan Prov Engn Lab Prevent & Control Technol Ve, Chengdu 610500, Peoples R China.
C3 Sichuan University; Chengdu Medical College
RP He, B (通讯作者)，Sichuan Univ, Coll Biomed Engn, Natl Engn Res Ctr Biomat, Chengdu 610065, Peoples R China.; Chen, JL (通讯作者)，Chengdu Med Coll, Sch Lab Med, Sichuan Prov Engn Lab Prevent & Control Technol Ve, Chengdu 610500, Peoples R China.
EM bhe@scu.edu.cn; chenjianlin@cmc.edu.cn
RI Guo, Zhaoyuan/MGA-0255-2025; He, Bin/B-3257-2015; Pu, Yuji/J-3168-2019
OI He, Bin/0000-0002-0939-9869; Pu, Yuji/0000-0002-4465-0262
FU National Natural Science Foundation of China [51903172, 51773130];
   National Natural Science Foundation of China
FX We would like to thank the financial support by the National Natural
   Science Foundation of China (51903172 and 51773130). We thank the
   Analytical & Testing Center of Sichuan University for FT-IR (Dr Yani
   Xie) work.
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   Shao W, 2017, CARBOHYD POLYM, V157, P1963, DOI 10.1016/j.carbpol.2016.11.087
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   Zhao X, 2017, BIOMATERIALS, V122, P34, DOI 10.1016/j.biomaterials.2017.01.011
NR 41
TC 14
Z9 17
U1 12
U2 54
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1525-7797
EI 1526-4602
J9 BIOMACROMOLECULES
JI Biomacromolecules
PD MAR 28
PY 2024
VL 25
IS 4
BP 2542
EP 2553
DI 10.1021/acs.biomac.4c00046
EA MAR 2024
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA NL6J2
UT WOS:001193696000001
PM 38547378
DA 2026-07-24
ER

PT J
AU Adeli, S
AF Adeli, Shamisa
TI Impact of multilayer compression bandages on subdressing pressure
   generated by a sNPWT: an experimental study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic; compression bandage; hard-to-heal; single-use negative pressure
   wound therapy; venous leg ulcer; wound; wound care; wound dressing;
   wound healing
ID LEG ULCERS; THERAPY
AB Objective: Venous leg ulcers (VLU) are a common, recurring condition resulting from venous stasis; they are especially prevalent in Northern Europe and the US. The overall prevalence of this condition is 1%, rising to 3% in patients >65 years of age. This study analysed the effect of a combination of single-use negative pressure wound therapy (sNPWT, VivereX NPWT system (Sunmedic AB, V & auml;llinge, Sweden) and compression bandaging (CB) in the treatment of VLUs. Method: An experimental in vivo extremity model was used to monitor and validate sub-dressing pressure. Results: There was no effect of the multilayer CB on the sNPWT therapeutical pressure. To the best of the author's knowledge, this is the first experimental study to examine variations in sub-dressing pressure within sNPWT systems following the application of a CB. Conclusion: In this study, therapeutical pressure induced by the VivereX device remained unaffected when used in combination with multilayer CB in the treatment of VLUs.
C1 [Adeli, Shamisa] Akad Hosp, Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital
RP Adeli, S (通讯作者)，Akad Hosp, Uppsala, Sweden.
EM Shamsia.adeli@gmail.com
CR Abouelhassan AE, Study of effect of four layer compression bandage versus four layer compression bandage with negative pressure wound therapy
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2026
VL 35
IS 1
BP 86
EP 88
DI 10.12968/jowc.2024.0036
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG6PA
UT WOS:001665330000001
PM 41528786
DA 2026-07-24
ER

PT J
AU Suzuki, H
   Watanabe, T
   Okazaki, T
   Notsuda, H
   Niikawa, H
   Matsuda, Y
   Noda, M
   Sakurada, A
   Hoshikawa, Y
   Aizawa, T
   Miura, T
   Okada, Y
AF Suzuki, H.
   Watanabe, T.
   Okazaki, T.
   Notsuda, H.
   Niikawa, H.
   Matsuda, Y.
   Noda, M.
   Sakurada, A.
   Hoshikawa, Y.
   Aizawa, T.
   Miura, T.
   Okada, Y.
TI Prolonged Negative Pressure Wound Therapy Followed by Split-Thickness
   Skin Graft Placement for Wide Dehiscence of Clamshell Incision After
   Bilateral Lung Transplantation: A Case Report
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 14th Congress of the Asian-Society-of-Transplantation
CY AUG 23-26, 2015
CL Singapore, SINGAPORE
SP Asian Soc Transplantat
ID DELAYED CHEST CLOSURE; OUTCOMES
AB Clamshell incision is a standard approach for bilateral lung transplantation, providing a good operative field; however, once wide dehiscence occurs, its management is sometimes difficult because of intense immunosuppression and malnutrition of the recipient. A 22 year-old man with idiopathic pulmonary arterial hypertension underwent cadaveric bilateral lung transplantation through a clamshell incision using standard cardiopulmonary bypass. He developed wound dehiscence on postoperative day (POD) 20 that resulted in exposure of the bilateral fifth ribs and open pneumothorax. Considering the extreme malnutrition and emaciation of the recipient, we avoided initial closure of the dehiscence. After the debridement of necrotic tissue, negative pressure wound therapy was initiated on POD 25 and was continued for approximately 6 months with trafermin spray application. Eventually, the wound, including the fifth ribs, was completely covered with granulation tissue except for the wire tying the sternum. On POD 217, the patient underwent removal of the sternal wire followed by split-thickness skin grafting. His wound was successfully closed and he was discharged without activity limitation on POD 265.
C1 [Suzuki, H.; Watanabe, T.; Okazaki, T.; Notsuda, H.; Niikawa, H.; Matsuda, Y.; Noda, M.; Sakurada, A.; Hoshikawa, Y.; Okada, Y.] Tohoku Univ, Inst Dev Aging & Canc, Dept Thorac Surg, Sendai, Miyagi 9808575, Japan.
   [Aizawa, T.; Miura, T.] Tohoku Univ, Grad Sch Med, Dept Plast & Reconstruct Surg, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University; Tohoku University
RP Watanabe, T (通讯作者)，Tohoku Univ, Dept Thorac Surg, Inst Dev Aging & Canc, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM tatsuaki_watanabe@yahoo.co.jp
RI Matsuda, Yasushi/AAB-4258-2021; 渡邉, 龍秋/PMQ-5150-2026
OI noda, masafumi/0000-0002-0318-3733
CR ASCHERMAN JA, 1995, J THORAC CARDIOV SUR, V110, P1030, DOI 10.1016/S0022-5223(05)80171-0
   Dondossola D, 2015, TRANSPL P, V47, P2145, DOI 10.1016/j.transproceed.2014.11.078
   Force SD, 2006, ANN THORAC SURG, V81, P2020, DOI 10.1016/j.athoracsur.2006.01.050
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   Waltzman JT, 2014, J BURN CARE RES, V35, pE338, DOI 10.1097/BCR.0000000000000009
NR 9
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD APR
PY 2016
VL 48
IS 3
BP 982
EP 984
DI 10.1016/j.transproceed.2015.12.107
PG 3
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA DN9TA
UT WOS:000377422400072
PM 27234784
DA 2026-07-24
ER

PT J
AU Asciutto, KC
   Acosta, S
   Borgfeldt, C
AF Asciutto, Katrin Christine
   Acosta, Stefan
   Borgfeldt, Christer
TI Negative Pressure Wound Therapy (NPWT) in Groin Wounds After
   Lymphadenectomy in Vulvar Cancer Patients
SO IN VIVO
LA English
DT Article
DE NPWT; lymphadenectomy groin; vulvar cancer
ID INGUINOFEMORAL LYMPHADENECTOMY; COMPLICATIONS; SURGERY; WOMEN;
   METAANALYSIS; VULVECTOMY; PREVENTION; MANAGEMENT; MORBIDITY; CARCINOMA
AB Background/Aim: Vulva cancer surgery is associated with a high level of morbidity mostly due to wound healing disorders in the inguinal region following lymphadenectomy. Our aim is to evaluate the feasibility of negative pressure wound therapy (NPWT) using the PICOT device in groin wounds after lymphadenectomy. Patients and Methods: The groins of twenty patients who underwent bilateral lymph node dissection were dressed with the PICOT device. All patients were followed prospectively with clinical controls up to three months postoperatively using a standardized study protocol. Results: A total of 11 patients (55%) developed a surgical site complication (SSC). One patient suffered from a wound rupture two days after surgery, six a lymphocele and four a surgical site infection. Operation time, blood loss, number of lymph nodes removed, length of hospital-stay and duration of PICOT treatment did not differ between women with and without SSCs. Conclusion: NPWT using the PICOT device seems to be a feasible method to reduce the severity of healing disorders in the groin after lymphadenectomy in vulva cancer patients.
C1 [Asciutto, Katrin Christine; Borgfeldt, Christer] Lund Unviv, Dept Obstet & Gynecol, Skane Univ Hosp, Lund, Sweden.
   [Acosta, Stefan] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Lund
   University; Skane University Hospital
RP Asciutto, KC (通讯作者)，Skane Univ Hosp, Dept Obstet & Gynecol, Klinikgatan 12, SE-22185 Lund, Sweden.
EM christine.asciutto@yahoo.com
RI Acosta, Stefan/JAX-3225-2023; Borgfeldt, Christer/AHB-9589-2022
OI Acosta, Stefan/0000-0002-3225-0798; Borgfeldt,
   Christer/0000-0003-2267-8325; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 28
TC 6
Z9 8
U1 1
U2 5
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2020
VL 34
IS 6
BP 3511
EP 3517
DI 10.21873/invivo.12192
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OP2QN
UT WOS:000587929100052
PM 33144461
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU de Souza, SC
   Mendes, CMC
   Meneses, JVL
   Dias, RM
AF de Souza, Sandro Cilindro
   Mendes, Carlos Mauricio Cardeal
   Meneses, Jose Valber Lima
   Dias, Rosana Menezes
TI Simplified vacuum dressing system: effectiveness and safety in wounds
   management
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Wounds and Injuries; Occlusive Dressings; Negative-Pressure Wound
   Therapy; Plastic Surgery
ID ASSISTED CLOSURE; PRESSURE; THERAPY; STATE
AB Purpose: Negative pressure wound therapy (NPWT) has revolutionized wound care, but its high cost reduces the procedure's availability. To solve the problem, streamlined vacuum dressings systems have been proposed, but the utility of these devices has been poorly studied. The objective of this study was to evaluate a simplified vacuum dressing system model (SVDM).Methods: Randomized clinical trial in which wounds were treated with SVDM compared to a complex occlusive dressing (silver hydrofiber, SHF). The analyzed outcomes were cleaning, presence of granulation tissue, clinical appearance, and indication for surgical closure of wounds.Results: Fifty injuries were treated (25 in each group), most located on lower limbs. SVDM proved to be more effective than SHF in the evaluated outcomes. Wound recalcitrance reduced the effectiveness of the equipment used. Despite its efficacy, complications occurred, the most frequent related to dressing changes: minor bleeding, foam adherence to a wound bed, and pain. Only for bleeding no favorable risk-benefit ratio was found. There were no severe complications, worsening conditions of injuries, or deaths.Conclusion: SVDM proved to be an effective and acceptably safe device for managing studied wounds.
C1 [de Souza, Sandro Cilindro; Mendes, Carlos Mauricio Cardeal] Univ Fed Bahia, Inst Ciencias Saude, Programa Posgrad, Salvador, BA, Brazil.
   [Meneses, Jose Valber Lima] Univ Fed Bahia, Fac Med, Dept Cirurgia Plast, Salvador, BA, Brazil.
   [Dias, Rosana Menezes] Hosp Carvalho Luz, Secretaria Saude Estado Bahia, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia
RP de Souza, SC (通讯作者)，Univ Fed Bahia, Inst Ciencias Saude, Programa Posgrad, Salvador, BA, Brazil.
EM sandrocilin@gmail.com
RI Mendes, Carlos Maurício Cardeal/AAC-1635-2019
OI Mendes, Carlos Maurício Cardeal/0000-0003-2089-5668; Souza,
   Sano/0000-0002-2888-6857; Lima meneses, Jose valber/0000-0001-5538-7108;
   Dias, Rosana/0000-0003-0030-2685
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NR 39
TC 2
Z9 4
U1 0
U2 1
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2022
VL 37
IS 9
AR e370906
DI 10.1590/acb370906
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7B6FW
UT WOS:000899227700001
PM 36515315
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Schnierer, M
   Haralambus, RMA
   Florczyk, A
AF Schnierer, M.
   Haralambus, R. M. A.
   Florczyk, A.
TI Disposable negative pressure wound therapy system enhances punch graft
   acceptance in equine distal limb wounds
SO EQUINE VETERINARY EDUCATION
LA English
DT Article; Early Access
DE horse; island grafts; skin grafts; VAC; wounds
ID MANAGEMENT
AB This case series describes the use of a disposable, canister-free negative pressure wound therapy (NPWT) system (PICO (R)) in combination with punch grafting for the treatment of distal limb wounds in three horses. Each horse presented with complex traumatic injuries resulting in delayed or inadequate healing of distal limb wounds. In all three cases, 6 mm full-thickness skin punch grafts were harvested from the neck and implanted into appropriately prepared wound beds. The PICO (R) system was applied post-operatively to support graft adherence and reduce complications such as infection. Bandage changes were performed between days 3 and 5, with NPWT maintained for up to 13 days. In all cases, the majority of grafts were successfully incorporated, with no signs of pain or adverse reactions to the NPWT system. Full epithelialisation was observed within 3-5 weeks post-grafting. The lightweight, user-friendly design of the PICO (R) system allowed for easier application compared to conventional NPWT systems and was well tolerated by the patients. These findings suggest that this method is a practical and effective adjunct to improve graft survival in the management of equine distal limb wounds.
C1 [Schnierer, M.; Haralambus, R. M. A.; Florczyk, A.] Univ Vet Med, Vienna, Austria.
C3 University of Veterinary Medicine Vienna
RP Schnierer, M (通讯作者)，Univ Vet Med, Vienna, Austria.
EM marlies.schnierer@gmail.com
CR Cantatore F, 2023, VET SCI, V10, DOI 10.3390/vetsci10080507
   Florczyk A, 2017, J EQUINE VET SCI, V55, P9, DOI 10.1016/j.jevs.2017.01.005
   Jordana M., 2011, USE VACUUM ASSISTED
   Kamus L, 2019, BMC VET RES, V15, DOI 10.1186/s12917-019-1829-5
   Krasner Diane L, 2002, Ostomy Wound Manage, V48, P38
   Rijkenhuizen ABM, 2005, PFERDEHEILKUNDE, V21, P413, DOI 10.21836/PEM20050503
   Schumacher J., 2019, EQUINE SURG, P381
   Smith & Nephew GmbH, 2025, US
NR 8
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD 2026 MAR 5
PY 2026
DI 10.1111/eve.70068
EA MAR 2026
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA EQ8MQ
UT WOS:001707554700001
OA hybrid
DA 2026-07-24
ER

PT J
AU Huang, RZ
   Cai, YT
   Zheng, TQ
   Lin, Q
AF Huang, Ruize
   Cai, Yangting
   Zheng, Tingqu
   Lin, Qiang
TI A case report on the successful treatment of a specific type of open
   ankle fracture-dislocation called logsplitter injury
SO SCIENCE PROGRESS
LA English
DT Article
DE Logsplitter injury; open fracture reduction; bone cements; negative
   pressure wound therapy; case report
ID OUTCOMES
AB This case report presents the successful management of a rare and complex open ankle fracture-dislocation known as a 'Logsplitter Injury', resulting from a high-energy traumatic event. The patient, a Chinese male in his early 20 s, sustained a severe left lower limb injury in a traffic accident. Initial clinical assessments revealed significant swelling, pain and an open fracture with extensive soft tissue damage. The patient underwent an emergency surgical intervention, involving meticulous wound debridement, internal fixation and reconstruction of the lower tibiofibular union, was performed. The use of vancomycin-loaded polymethylmethacrylate bone cement and negative pressure wound therapy contributed to the favourable outcome. Post-operative care encompassed comprehensive analgesia and infection prevention measures, resulting in substantial ankle function recovery. Follow-up assessments revealed healed fractures and excellent joint alignment, with the patient attaining an AOFAS score of 85, indicative of good functional recovery. This case underscores the effectiveness of individualised treatment plans and multidisciplinary teamwork in managing such challenging injuries, offering valuable clinical insights and highlighting the potential for successful outcomes with timely and precise surgical interventions.
C1 [Huang, Ruize; Cai, Yangting] Guangzhou Univ Tradit Chinese Med, Guangzhou, Peoples R China.
   [Cai, Yangting; Lin, Qiang] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Peoples R China.
   [Zheng, Tingqu] Shenzhen Pingle Orthoped Hosp, Dept Orthoped, Shenzhen, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangdong Pharmaceutical
   University
RP Lin, Q (通讯作者)，Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Peoples R China.
EM 20211120785@stu.gzucm.edu.cn
OI HUANG, Rui-Ze/0000-0001-5476-0919; Cai, Yang-Ting/0000-0003-3549-7793
CR Aljawadi A, 2022, ARCH ORTHOP TRAUM SU, V142, P425, DOI 10.1007/s00402-020-03705-y
   Bible JE, 2014, J ORTHOP TRAUMA, V28, P200, DOI 10.1097/01.bot.0000435605.83497.53
   Burwell H N, 1965, J Bone Joint Surg Br, V47, P634
   Cao MM, 2022, FRONT SURG, V9, DOI 10.3389/fsurg.2022.965814
   Gagnier JJ, 2013, DTSCH ARZTEBL INT, V110, P603, DOI [10.1111/head.12246, 10.1136/bcr-2013-201554, 10.7453/gahmj.2013.008, 10.3238/arztebl.2013.0603, 10.1186/1752-1947-7-223]
   KELLGREN JH, 1957, ANN RHEUM DIS, V16, P494, DOI 10.1136/ard.16.4.494
   Kitaoka HB, 1997, FOOT ANKLE INT, V18, P187, DOI 10.1177/107110079701800315
   Li JF, 2019, MED SCI MONITOR, V25, P5343, DOI 10.12659/MSM.915921
   Nishida M, 2025, J ORTHOP SCI, V30, P142, DOI 10.1016/j.jos.2024.03.006
   Peterson DL, 2020, J ORTHOP TRAUMA, V34, P376, DOI 10.1097/BOT.0000000000001734
   Sidhu SP, 2022, J ORTHOP TRAUMA, V36, P152, DOI 10.1097/BOT.0000000000002237
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Wang Z, 2017, J ORTHOP SURG RES, V12, DOI 10.1186/s13018-016-0502-y
   Yin ZW, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019380
   Zhang YW, 2021, INJURY, V52, P358, DOI 10.1016/j.injury.2020.11.043
NR 15
TC 1
Z9 1
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0036-8504
EI 2047-7163
J9 SCI PROGRESS-UK
JI Sci. Prog.
PD JAN
PY 2025
VL 108
IS 1
AR 00368504251324345
DI 10.1177/00368504251324345
PG 12
WC Education, Scientific Disciplines; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Science & Technology - Other Topics
GA Z1Z7J
UT WOS:001436979800001
PM 40033522
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kim, PJ
   Fernandez, L
   Matthews, M
AF Kim, Paul J.
   Fernandez, Luis
   Matthews, Marc
TI Early Experience and Recommendations for the Use of an Automated
   Estimator of Solution Volume for Negative Pressure Wound Therapy With
   Instillation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE automation; instillation; negative pressure wound therapy; solution
ID STANDARD
AB Introduction. NPWTi is a device that combines the benefits of traditional NPWT with periodic irrigation. This automated device allows for preprogrammed cycles of dwelling of a solution and negative pressure onto the wound surface. Its adoption has been hampered by the perceived difficulty of estimating the volume of solution needed per dwell cycle. A new software update includes an AESV that makes this determination for the clinician. Objective. This case series of 23 patients presents the observations of 3 experienced users at 3 institutions who employed NPWTi with the AESV. Materials and Methods. The authors subjectively assessed the wounds to determine whether the expected clinical result was achieved utilizing AESV on a variety of anatomical locations and wound types. Results. The AESV demonstrated the ability to reliably estimate adequate solution amount in 65% (15/23) of cases. In wounds greater than 120 cm(3), the AESV underestimated the amount of solution needed. Conclusion. To the authors' knowledge, this is the first publication describing the use of AESV for NPWTi. The benefits and limitations of this software upgrade are reported and recommendations for optimal use are provided.
C1 [Kim, Paul J.] Univ Texas Southwestern Med Ctr Dallas, Plast Surg, Dallas, TX 75390 USA.
   [Fernandez, Luis] Univ Texas Hlth Sci Ctr Tyler, Dept Surg, Div Trauma Surg Surg Crit Care, Tyler, TX USA.
   [Matthews, Marc] Univ Arizona, Coll Med, Dept Surg, Phoenix, AZ USA.
   [Matthews, Marc] Arizona Burn Ctr, Phoenix, AZ USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas-Health Sciences
   Center at Tyler (UTHSCT); University of Arizona
RP Kim, PJ (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, 1801 Inwood Rd, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
RI ; Oceja, Luis/B-5599-2011
OI , Paul/0000-0002-6186-6890; 
CR Gabriel A., 2014, Eplasty, V14
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Kim PJ, 2022, INT WOUND J, V19, P888, DOI 10.1111/iwj.13689
   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Lessing M Christian, 2013, Eplasty, V13, pe51
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   Yang C, 2017, WOUNDS, V29, P240
NR 14
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2023
VL 35
IS 2
BP E82
EP E87
DI 10.25270/wnds/22029
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MK7
UT WOS:001071604700006
PM 36897619
DA 2026-07-24
ER

PT J
AU Kamarajah, SK
   Markar, SR
AF Kamarajah, Sivesh K.
   Markar, Sheraz R.
TI Navigating complexities and considerations for suspected anastomotic
   leakage in the upper gastrointestinal tract: A state of the art review
SO BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
LA English
DT Review
DE Anastomotic leak; Oesophagectomy; Gastrectomy; Surgical treatment; Risk
   factors
ID VACUUM-ASSISTED CLOSURE; PERIOPERATIVE CHEMOTHERAPY; SURGICAL-TREATMENT;
   OPEN-LABEL; ESOPHAGECTOMY; MANAGEMENT; MULTICENTER; DIAGNOSIS; IMPACT;
   CANCER
AB This state-of-the-art review explores the intricacies of anastomotic leaks following oesophagectomy and gastrectomy, crucial surgeries for globally increasing esophageal and gastric cancers. Despite advancements, anastomotic leaks occur in up to 30 % and 10 % of oesophagectomy and gastrectomy cases, respectively, leading to prolonged hospital stays, substantial impact upon short- and long-term health-related quality of life and greater mortality. Recognising factors contributing to leaks, including patient characteristics and surgical techniques, are vital for preoperative risk stratification. Diagnosis is challenging, involving clinical signs, biochemical markers, and various imaging modalities. Management strategies range from non-invasive approaches, including antibiotic therapy and nutritional support, to endoscopic interventions such as stent placement and emerging vacuum-assisted closure devices, and surgical interventions, necessitating timely recognition and tailored interventions. A step-up approach, beginning non-invasively and progressing based on treatment success, is more commonly advocated. This comprehensive review highlights the absence of standardised treatment algorithms, emphasizing the importance of individualised patient-specific management.
C1 [Kamarajah, Sivesh K.] Univ Birmingham, Inst Appl Hlth Res, Dept Global Hlth & Surg, Birmingham, England.
   [Markar, Sheraz R.] Univ Oxford, Nuffield Dept Surg, Surg Intervent Trials Unit, Oxford, England.
C3 University of Birmingham; University of Oxford
RP Markar, SR (通讯作者)，Univ Oxford, Nuffield Dept Surg, Surg Intervent Trials Unit, Oxford, England.
EM sheraz.markar@nds.ox.ac.uk
RI Kamarajah, Sivesh K/AAE-8159-2021
OI Kamarajah, Sivesh K/0000-0002-2748-0011; Markar,
   Sheraz/0000-0002-4040-5681
CR Alderson D, 2017, LANCET ONCOL, V18, P1249, DOI 10.1016/S1470-2045(17)30447-3
   Bhat MA, 2006, ANN THORAC SURG, V82, P1857, DOI 10.1016/j.athoracsur.2006.05.101
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Chon SH, 2022, DIS ESOPHAGUS, V35, DOI 10.1093/dote/doab067
   Chon SH, 2020, ENDOSCOPY, V52, pE166, DOI 10.1055/a-1047-0244
   Cunningham D, 2017, LANCET ONCOL, V18, P357, DOI 10.1016/S1470-2045(17)30043-8
   Cunningham D, 2006, NEW ENGL J MED, V355, P11, DOI 10.1056/NEJMoa055531
   de Mooij CM, 2019, J CLIN MED, V8, DOI 10.3390/jcm8112005
   Dent B, 2016, BRIT J SURG, V103, P1033, DOI 10.1002/bjs.10175
   Elsayed H, 2012, ANN ROY COLL SURG, V94, P579, DOI 10.1308/003588412X13373405388095
   Fumagalli U, 2019, WORLD J GASTROENTERO, V25, P356, DOI 10.3748/wjg.v25.i3.356
   Goense L, 2017, EUR RADIOL, V27, P4426, DOI 10.1007/s00330-017-4802-3
   Goense L, 2016, ANN THORAC SURG, V102, P1798, DOI 10.1016/j.athoracsur.2016.08.027
   Griffin SM, 2021, SURGERY, V170, P2, DOI 10.1016/j.surg.2021.01.040
   Griffin SM, 2021, ANN SURG ONCOL, V28, P3011, DOI 10.1245/s10434-020-09200-3
   Griffin SM, 2001, BRIT J SURG, V88, P1346, DOI 10.1046/j.0007-1323.2001.01918.x
   Gronnier C, 2014, ANN SURG, V260, P764, DOI 10.1097/SLA.0000000000000955
   Gujjuri RR, 2021, DIS ESOPHAGUS, V34, DOI 10.1093/dote/doaa085
   Guo JT, 2014, WORLD J SURG ONCOL, V12, DOI 10.1186/1477-7819-12-402
   Hu Z, 2011, DIS ESOPHAGUS, V24, P100, DOI 10.1111/j.1442-2050.2010.01102.x
   Jiang B, 2018, DIS ESOPHAGUS, V31, DOI 10.1093/dote/doy041
   Kamarajah SK, 2020, BJS-BRIT J SURG, V107, P1648, DOI 10.1002/bjs.11749
   Kamarajah SK, 2020, BJS OPEN, V4, P563, DOI 10.1002/bjs5.50298
   Kamarajah SK, 2020, ANN SURG ONCOL, V27, P2414, DOI 10.1245/s10434-020-08199-x
   Kamarajah SK, 2021, BJS-BRIT J SURG, V108, P66, DOI 10.1093/bjs/znaa034
   Kamarajah SK, 2020, DIS ESOPHAGUS, V33, DOI 10.1093/dote/doz089
   Kamarajah SK, 2020, WORLD J SURG, V44, P1173, DOI 10.1007/s00268-019-05259-6
   Kauer WKH, 2008, SURG ENDOSC, V22, P50, DOI 10.1007/s00464-007-9504-5
   Koëter M, 2017, INT J RADIAT ONCOL, V97, P813, DOI 10.1016/j.ijrobp.2016.11.054
   Ladak F, 2019, SURG ENDOSC, V33, P384, DOI 10.1007/s00464-018-6503-7
   Lange J, 2023, SURG ENDOSC, V37, P3657, DOI 10.1007/s00464-023-09861-7
   Low DE, 2015, ANN SURG, V262, P286, DOI 10.1097/SLA.0000000000001098
   Manghelli JL, 2019, J THORAC DIS, V11, P131, DOI 10.21037/jtd.2018.12.13
   Markar SR, 2013, ANN SURG ONCOL, V20, P4274, DOI 10.1245/s10434-013-3189-x
   Martin LW, 2005, ANN SURG, V242, P392, DOI 10.1097/01.sla.0000179645.17384.12
   Miller DL, 2018, ANN THORAC SURG, V105, P200, DOI 10.1016/j.athoracsur.2017.07.053
   Oesophago-Gastric Anastomosis Study Group on behalf of the West Midlands Research C, 2021, ANN SURG
   Ohi M, 2017, ESOPHAGUS-TOKYO, V14, P351, DOI 10.1007/s10388-017-0585-5
   Page RD, 2005, EUR J CARDIO-THORAC, V27, P337, DOI 10.1016/j.ejcts.2004.10.053
   Palmes D, 2011, LANGENBECK ARCH SURG, V396, P857, DOI 10.1007/s00423-011-0818-3
   Rausa E, 2018, DIS ESOPHAGUS, V31, DOI 10.1093/dote/doy060
   Shao SL, 2021, J PERS MED, V11, DOI 10.3390/jpm11080748
   Shuto K, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12492
   Stippel DL, 2005, DIS ESOPHAGUS, V18, P267, DOI 10.1111/j.1442-2050.2005.00487.x
   Strauss C, 2010, ANN SURG, V251, P647, DOI 10.1097/SLA.0b013e3181c1aeb8
   Tang H, 2012, J GASTROINTEST SURG, V16, P722, DOI 10.1007/s11605-011-1788-z
   Turkyilmaz A, 2009, DIS ESOPHAGUS, V22, P119, DOI 10.1111/j.1442-2050.2008.00866.x
   van Heijl M, 2010, BRIT J SURG, V97, P726, DOI 10.1002/bjs.6971
   van Rossum PSN, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12472
   van Workum F, 2017, ANN THORAC SURG, V103, P267, DOI 10.1016/j.athoracsur.2016.07.010
   Wang SM, 2024, LANCET GASTROENTEROL, V9, P229, DOI 10.1016/S2468-1253(23)00366-7
   Wiggins T, 2015, SURG ONCOL, V24, P181, DOI 10.1016/j.suronc.2015.06.011
   Zheng QF, 2013, EUR J CARDIO-THORAC, V43, P274, DOI 10.1093/ejcts/ezs285
NR 54
TC 8
Z9 8
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1521-6918
EI 1532-1916
J9 BEST PRACT RES CL GA
JI Best Pract. Res. Clin. Gastroenterol.
PD JUN
PY 2024
VL 70
AR 101916
DI 10.1016/j.bpg.2024.101916
EA JUL 2024
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA ZY6G8
UT WOS:001278879000001
PM 39053974
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Salati, SA
   Al Aithan, B
AF Salati, Sajad Ahmad
   Al Aithan, Bandar
TI Post clubfoot release skin necrosis: a preventable disaster
SO LIBYAN JOURNAL OF MEDICINE
LA English
DT Letter
DE club foot complications; necrosis; topical negative pressure;
   vacuum-assisted closure (VAC); flaps
ID CHILDREN
AB Complications of pedal wounds closed primarily after release of neglected cases of club foot are well known in literature. We treated a 12-year-old boy presenting with widespread necrosis involving medial aspect of foot after release of neglected talipes equinovarus. Such widespread necrosis is even known to end up in amputations and permanent disabilities. In our case, the foot was successfully salvaged by resorting to dedicated wound care, multiple debridements, use of topical negative pressure (vacuum-assisted closure - VAC), and skin grafting. Various means to prevent such adverse events are also presented. The aim of publishing this case is to stress the need to:
   1. Take proper measures preoperatively in neglected club feet to decrease the impact of deformity.
   2. To be aware of various different flaps and methods of closure as mentioned in literature and to reaffirm the fact that primary closures done under tension are bound to fail and end up in disasters.
   3. To be patient and use the modern concepts of wound management like topical negative pressure if such unfortunate complications do occur and thereby attempt to salvage the feet.
C1 [Salati, Sajad Ahmad] King Fahad Med City, Riyadh, Saudi Arabia.
   [Al Aithan, Bandar] Mil Hosp, Riyadh, Saudi Arabia.
C3 Prince Sultan Military Medical City
RP Salati, SA (通讯作者)，King Fahad Med City, Riyadh, Saudi Arabia.
EM docsajad@yahoo.co.in; alaithanbander@hotmail.com
RI SALATI, SAJAD AHMAD/HJI-7018-2023
OI SALATI, SAJAD AHMAD/0000-0003-2998-7542
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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   PALANIAPPAN L, 2005, EUR J ORTHOP SURG TR, V15, P28
   Roposch A, 1999, J BONE JOINT SURG BR, V81B, P398, DOI 10.1302/0301-620X.81B3.9341
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NR 10
TC 0
Z9 0
U1 0
U2 3
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 1993-2820
J9 LIBYAN J MED
JI Libyan J. Med.
PY 2011
VL 6
AR 6415
DI 10.3402/ljm.v6i0.6415
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 843VA
UT WOS:000296700900013
PM 21526037
OA gold
DA 2026-07-24
ER

PT J
AU Kokodziejczyk, J
   Czarny, J
   Królak, S
   Rutkowska, S
   Morycinski, S
   Mankowski, P
   Bartkowska-Sniatkowska, A
   Wachowiak, J
   Derwich, K
   Zajac-Spychaka, O
AF Kokodziejczyk, Julia
   Czarny, Jakub
   Krolak, Staniskaw
   Rutkowska, Sandra
   Morycinski, Sebastian
   Mankowski, Przemyskaw
   Bartkowska-Sniatkowska, Alicja
   Wachowiak, Jacek
   Derwich, Katarzyna
   Zajac-Spychaka, Olga
TI Successful Treatment of Fournier's Gangrene in Child with Relapsed Acute
   Lymphoblastic Leukemia: Case Report and Review of the Literature
SO INFECTION AND DRUG RESISTANCE
LA English
DT Review
DE Fournier's gangrene; Pseudomonas aeruginosa; multidrug resistance;
   therapy; child; acute lymphoblastic leukemia
ID VACUUM-ASSISTED CLOSURE; NEUTROPENIA; THERAPY
AB Neutropenia associated with onco-hematological treatment may contribute to high-mortality infections, especially caused by multidrug-resistant pathogens. In a 4-year-old girl treated due to early isolated central nervous system (CNS) relapse of B-cell acute lymphoblastic leukemia, skin lesions with traits of Fournier's gangrene caused by Klebsiella pneumoniae carbapenemase (KPC)producing Pseudomonas aeruginosa (PsA). The patient was treated with broad-spectrum antibiotic therapy and the wound was debrided and treated with VAC (vacuum-assisted closure) successfully. Despite further intensive anticancer treatment complicated by reactivation of PsA infection, there was no other episode of invasive infection anymore and, nowadays, the patient has been in complete remission for 13 months. The aim of this report is to mention that Fournier's gangrene is a rapid and potentially fatal infectious complication of chemotherapy in onco-hematological pediatric patients, especially if caused by MDR (multidrug-resistant) pathogens. Successful treatment of this necrotizing fasciitis saves a patient's life and allows to continue an effective anticancer therapy.
C1 [Kokodziejczyk, Julia; Czarny, Jakub] Poznan Univ Med Sci, Student Sci Soc, Szpitalna Str 27-33, PL-60572 Poznan, Poland.
   [Rutkowska, Sandra; Wachowiak, Jacek; Derwich, Katarzyna; Zajac-Spychaka, Olga] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Oncol Hematol & Transplantol, Poznan, Poland.
   [Morycinski, Sebastian; Mankowski, Przemyskaw] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Surg Traumatol & Urol, Poznan, Poland.
   [Bartkowska-Sniatkowska, Alicja] Poznan Univ Med Sci, Carol Jonschers Clin Hosp, Dept Pediat Anesthesiol & Intens Therapy, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences
RP Kokodziejczyk, J (通讯作者)，Poznan Univ Med Sci, Student Sci Soc, Szpitalna Str 27-33, PL-60572 Poznan, Poland.
EM 86066@student.ump.edu.pl
OI Czarny, Jakub/0000-0003-4996-9157; Królak,
   Stanisław/0009-0006-6253-2629; Derwich, Katarzyna/0000-0001-7239-4035;
   Kołodziejczyk, Julia/0000-0002-2940-5445
CR Aguilera-Alonso D, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.02183-19
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   Dale DC, 2016, CURR OPIN HEMATOL, V23, P1, DOI 10.1097/MOH.0000000000000208
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   He R, 2023, FRONT SURG, V9, DOI 10.3389/fsurg.2022.1075968
   Iacovelli V, 2021, WORLD J UROL, V39, P121, DOI 10.1007/s00345-020-03170-7
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NR 30
TC 0
Z9 1
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2025
VL 18
BP 1667
EP 1673
DI 10.2147/IDR.S490240
PG 7
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 0ZI3V
UT WOS:001459604100001
PM 40190595
OA gold
DA 2026-07-24
ER

PT J
AU Ozturk, E
   Ozguc, H
   Yilmazlar, T
AF Ozturk, Ersin
   Ozguc, Halil
   Yilmazlar, Tuncay
TI The use of vacuum assisted closure therapy in the management of
   Fournier's gangrene
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fournier's gangrene; VAC therapy; Negative pressure vacuuming; Wound
   care
ID NEGATIVE-PRESSURE THERAPY; WOUND CONTROL; SKIN-GRAFTS; RECONSTRUCTION;
   DEVICE; ULCERS; FLORA
AB BACKGROUND: Vacuum Assisted Closure (VAC; Kinetic Concepts, Inc., San Antonio, TX) has been Used to successfully treat a variety of complex Wounds. This technique was investigated for use in managing Fournier's gangrene following initial debridement.
   METHODS: Ten patients with Fournier's gangrene were treated in this study. After initial surgical debridement, 5 were treated using conventional therapy and 5 were treated with VAC at each dressing change. The effectiveness and cost of VAC for this indication were assessed: patient and physician satisfaction were also determined.
   RESULTS: Conventional and VAC treatment were equally effective in healing the wounds. The total costs of each treatment were similar. With the use of VAC, patients had fewer dressing changes, less pain, fewer skipped meals, and greater mobility, Hands-on treatment time was decreased for physicians using VAC.
   CONCLUSIONS: VAC therapy is an effective and economical way to manage Fournier's gangrene. Patients and physicians were more satisfied with VAC therapy than with conventional treatment. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ozturk, Ersin; Ozguc, Halil; Yilmazlar, Tuncay] Uludag Univ, Fac Med, Dept Gen Surg 16069, Gorukle, Bursa, Turkey.
C3 Uludag University
RP Ozturk, E (通讯作者)，Uludag Univ, Fac Med, Dept Gen Surg 16069, Gorukle, Bursa, Turkey.
EM drozturk@uludag.edu.tr
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NR 27
TC 79
Z9 95
U1 0
U2 7
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2009
VL 197
IS 5
BP 660
EP 665
DI 10.1016/j.amjsurg.2008.04.018
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 442SB
UT WOS:000265859800023
PM 18789410
DA 2026-07-24
ER

PT J
AU Wongworawat, MD
   Schnall, SB
   Holtom, PD
   Moon, C
   Schiller, F
AF Wongworawat, MD
   Schnall, SB
   Holtom, PD
   Moon, C
   Schiller, F
TI Negative pressure dressings as an alternative technique for the
   treatment of infected wounds
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article; Proceedings Paper
CT 12th Annual Meeting of the Musculoskeletal-Infection-Society
CY AUG 01-03, 2002
CL ASPEN, COLORADO
SP Musculoskeletal Infect Soc
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; TISSUE DEFECTS; EXPERIENCE;
   SYSTEM; DEVICE
AB Coverage of wounds caused by infection and subsequent treatment often are variable because of the location of the wound and wound size. Although much research has been done to expand the indications of negative pressure wound treatment systems, little investigation has been done to quantify the reduction of wound size for vacuum-assisted closure treatment in the presence of infection. In this series, 14 patients who had wounds caused by infections were treated with the vacuum-assisted wound closure system. All wounds were greater than 20 cm(2). The duration of treatment averaged 10 days (range, 2-27 days), and the initial wound size averaged 70 cm(2) (range, 22.5-288 cm(2)). After the course of treatment, the final wound size averaged 39 cm(2) (range, 10-147 cm(2)). The average wound size reduction was 43%. This method seems to enhance the rapidity of wound reduction, and because it is a closed system of treatment, it has the added benefit of minimizing exposure of staff and other patients to communicable diseases. Vacuum-assisted wound closure systems add another option in the care of musculoskeletal infections.
C1 Univ So Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA.
C3 University of Southern California
RP Schnall, SB (通讯作者)，2025 Zonal Ave,GNH 3900, Los Angeles, CA 90089 USA.
RI ; Wongworawat, Montri/I-6546-2019
OI Moon, Charles/0000-0003-3180-8320; Wongworawat,
   Montri/0000-0003-2530-5612
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
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   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Joseph E, 2000, WOUNDS, V12, P60
   Mooney JF, 2000, CLIN ORTHOP RELAT R, P26
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Schnall SB, 1997, CLIN ORTHOP RELAT R, P286
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NR 14
TC 36
Z9 49
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD SEP
PY 2003
IS 414
BP 45
EP 48
DI 10.1097/01.blo.0000084400.53464.02
PG 4
WC Orthopedics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 721XM
UT WOS:000185343800007
PM 12966275
DA 2026-07-24
ER

PT J
AU Kilpadi, D
   Bower, CE
   Reade, CC
   Robinson, PJ
   Sun, YS
   Zeri, R
   Nifong, LW
   Wooden, WA
AF Kilpadi, D
   Bower, CE
   Reade, CC
   Robinson, PJ
   Sun, YS
   Zeri, R
   Nifong, LW
   Wooden, WA
TI Effect of Vacuum Assisted Closure® Therapy on early systemic cytokine
   levels in a swine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PORCINE SKIN WOUNDS; GROWTH-FACTOR-BETA; GENE-EXPRESSION; TGF-BETA;
   INTERLEUKIN-6; IL-10; INFLAMMATION; ACTIVATION; PRESSURE; SURGERY
AB Vacuum Assisted Closure (R) (V.A.C.(R)) Therapy has previously been shown to facilitate healing of wounds. However, the physiological mechanism(s) of this treatment modality and its systemic effects require further investigations. The goal of this porcine study was to investigate the effect of V.A.C.(R) Therapy on the systemic distribution of the inflammatory cytokines interleukin (IL)-6, IL-8, IL-10, and transforming growth factor-beta 1. Twelve pigs were each given one full-thickness excisional wound. using electrocautery. Six of the pigs were treated with V.A.C.(R) Therapy and six with saline-moistened gauze. Serum samples were collected immediately after Wound creation, and hourly for 4 hours. Samples were analyzed using commercially available enzyme-linked immunosorbent assay kits. During the initial 4 hours of treatment, V.A.C.(R) Therapy resulted in earlier and greater peaking of IL-10 and maintenance of IL-6 levels compared with saline-moistened gauze controls, which showed decreased IL-6 values over the first hour (both at p < 0.05). No other treatment-based differences were detected.
C1 KCI, Global R&D, New Technol, San Antonio, TX 78249 USA.
   E Carolina Univ, Brody Sch Med, Dept Surg, Greenville, NC USA.
C3 University of North Carolina; East Carolina University
RP Kilpadi, D (通讯作者)，KCI, Global R&D, New Technol, 6203 Farinon, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
RI Robinson, Phil/HZH-9227-2023; Bower, Curtis/ABG-6186-2021
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NR 42
TC 35
Z9 52
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2006
VL 14
IS 2
BP 210
EP 215
DI 10.1111/j.1743-6109.2006.00112.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 040CW
UT WOS:000237357600016
PM 16630111
DA 2026-07-24
ER

PT J
AU Keskin, M
   Karabekmez, FE
   Yilmaz, E
   Tosun, Z
   Savaci, N
AF Keskin, Mustafa
   Karabekmez, Furkan E.
   Yilmaz, Erkan
   Tosun, Zekeriya
   Savaci, Nedim
TI Vacuum-assisted closure of wounds and anxiety
SO SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND
   SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Congress of the
   Balkan-Association-for-Plastic-Reconstructive-and-Aesthetic-Surgery
CY MAY 22-26, 2007
CL Izmir, TURKEY
SP Balkan Assoc Plast Reconstruct & Aesthet Surg
DE anxiety; pain; VAC
ID POSTTRAUMATIC-STRESS-DISORDER; SURGERY
AB The aim of this study was to investigate the degree of anxiety in patients in whom the vacuum-assisted closure (VAC) of wounds was used. Psychological evaluations were made on the day before VAC was applied and at the 10th day of treatment in 20 patients with traumatic wounds of the lower extremity. Anxiety was measured with the Hamilton Rating Scale for Anxiety and with the State Anxiety Inventory test. The same measurements were also made in 20 further patients with similar wounds but managed with classic treatment as controls. Both groups showed a significant increase in anxiety during the 10 days. The mean (SD) differences in the anxiety scores measured during the 10-day period were significantly higher in the group treated by VAC than in the control group, State Anxiety Inventory test (14.0 (2.3) compared with 2.6 (1.2), p < 0.001) and Hamilton Rating Scale for Anxiety test (4.4 (0.6) compared with 1.3 (0.6), p < 0.001). Although we think that VAC is an effective tool for treating lower extremity wounds, we have concerns about possible accompanying psychological effects.
C1 [Keskin, Mustafa; Karabekmez, Furkan E.; Tosun, Zekeriya; Savaci, Nedim] Univ Selcuk, Meram Med Fac, Dept Plast & Reconstruct Surg, TR-42080 Konya, Turkey.
   [Yilmaz, Erkan] Univ Selcuk, Meram Med Fac, Dept Psychiat, TR-42080 Konya, Turkey.
C3 Selcuk University; Selcuk University
RP Keskin, M (通讯作者)，Univ Selcuk, Meram Med Fac, Dept Plast & Reconstruct Surg, S Blok 211, TR-42080 Konya, Turkey.
EM drmkeskin@hotmail.com
RI Keskin, Mustafa/W-5938-2019; Savaci, Nedim/ABT-6759-2022; Karabekmez,
   Furkan/AAA-1820-2020
OI Keskin, Mustafa/0000-0003-2066-7454; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Yazici K, 1998, TURK PSIKIYATR DERG, V9, P114
NR 13
TC 25
Z9 28
U1 0
U2 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0284-4311
J9 SCAND J PLAST RECONS
JI Scand. J. Plast. Reconstr. Surg. Hand Surg.
PY 2008
VL 42
IS 4
BP 202
EP 205
DI 10.1080/02844310802091586
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 342SS
UT WOS:000258804400007
PM 18763197
DA 2026-07-24
ER

PT J
AU De Caridi, G
   Serra, R
   Massara, M
   Barone, M
   Grande, R
   Butrico, L
   Mastroroberto, P
   de Franciscis, S
   Monaco, F
AF De Caridi, Giovanni
   Serra, Raffaele
   Massara, Mafalda
   Barone, Mario
   Grande, Raffaele
   Butrico, Lucia
   Mastroroberto, Pasquale
   de Franciscis, Stefano
   Monaco, Francesco
TI VAC therapy for the treatment of complex wounds after cardio-thoracic
   surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiothoracic surgery; Dehiscence; VAC; Vacuum-assisted closure; Wound
   healing
ID ASSISTED CLOSURE; NEGATIVE-PRESSURE; POSTSTERNOTOMY MEDIASTINITIS;
   EXPERIENCE; MANAGEMENT
AB The aim of this study is to report our experience about the treatment of complex sternal and thoracic wounds following cardiothoracic surgery, using vacuum-assisted closure (VAC therapy. Twelve patients presenting with sternal (five cases) and thoracic (seven cases) wounds that were difficult to heal were treated through VAC therapy after the first surgical debridement. The duration of VAC application ranged from 12 to 36 days with an average hospital stay of 24.6 +/- 11.4 days. During a mean follow-up of 12 months, we observed complete wound healing in seven cases (58.3%), in an average period of 25.5 +/- 14.3 days; one patient died during follow-up, two patients were lost to follow-up and two patients required definitive surgical closure of the wound cavity. In conclusion, VAC therapy promotes faster wound healing, with shorter hospital stay and subsequent lesser in-hospital cost, reducing the mortality rate in the long run. It also promotes early rehabilitation and alleviates the need for a second procedure, thus improving patient satisfaction, with minimal discomfort or inconvenience.
C1 [De Caridi, Giovanni; Massara, Mafalda; Barone, Mario; Monaco, Francesco] Univ Messina, Cardiovasc & Thorac Dept, Policlin G Martino Hosp, Messina, Italy.
   [Serra, Raffaele; Grande, Raffaele; Butrico, Lucia; de Franciscis, Stefano] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, Catanzaro, Italy.
   [Serra, Raffaele; de Franciscis, Stefano] Magna Graecia Univ Catanzaro, Int Res & Educ Program Clin & Expt Biotechnol, Interuniv Ctr Phlebolymphol CIFL, Catanzaro, Italy.
   [Mastroroberto, Pasquale] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
C3 University of Messina; University Messina Policlin; Magna Graecia
   University of Catanzaro; Magna Graecia University of Catanzaro; Magna
   Graecia University of Catanzaro
RP Serra, R (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM rserra@unicz.it
RI De Caridi, Giovanni/KRQ-6363-2024; Serra, Raffaele/AAA-6874-2022;
   Grande, Raffaele/AAO-1388-2020; /AAM-9453-2020
OI De Caridi, Giovanni/0000-0002-1859-9010; Serra,
   Raffaele/0000-0003-4477-7412; de Franciscis,
   Stefano/0000-0001-9365-4609; MONACO, Francesco/0000-0002-5617-7943;
   Barone, Mario/0000-0003-4842-7057; Grande, Raffaele/0000-0003-2873-0104;
   
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 8
Z9 11
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 759
EP 762
DI 10.1111/iwj.12369
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600078
PM 25229399
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Weinand, C
AF Weinand, Christian
TI The Vacuum-Assisted Closure (VAC) Device for Hastened Attachment of a
   Superficial Inferior-Epigastric Flap to Third-Degree Burns on Hand and
   Fingers
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID NEGATIVE-PRESSURE DRESSINGS; SUBATMOSPHERIC PRESSURE; UPPER EXTREMITY;
   THERAPY; COVERAGE; PEDICLE; RECONSTRUCTION; BOLSTER; TRIAL
AB The vacuum-assisted closure (VAC) device has a wide range of clinical applications, including treatment of infected surgical wounds, traumatic wounds, pressure ulcers, wounds with exposed bone and hardware, diabetic foot ulcers, and venous stasis ulcers. Increased release of growth factors has been described, leading to improved vascularization and thereby formation of new tissue. The system is also used in burn surgery for reconstructive purposes. In this case report, a patient suffered from a third-degree burn injury to the dorsum of the hand with exposure of tendons, necessitating the use of a flap reconstruction. The patient was treated with a superficial inferior-epigastric artery-based flap and the VAC system was applied in a created glove-like shape. Hastened attachment of the flap onto the exposed fingers was observed after 4 days. The author reports on the additional use of the VAC system to hasten flap attachment in a patient with a burn injury to the dorsum of the hand. (J Burn Care Res 2009;30:362-365)
C1 Washington Hosp Ctr, Burns Dept, Div Burns, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center
RP Weinand, C (通讯作者)，Washington Hosp Ctr, Burns Dept, Div Burns, 110 Irving St NW, Washington, DC 20010 USA.
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NR 33
TC 8
Z9 11
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2009
VL 30
IS 2
BP 362
EP 365
DI 10.1097/BCR.0b013e318198a77e
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 412QI
UT WOS:000263738900027
PM 19242270
DA 2026-07-24
ER

PT J
AU Lioupis, C
   Kotsis, T
   Barbatis, C
   Seretis, E
   Nomikos, A
   Volondakis-Baltatzis, I
   Papalois, A
   Andrikopoulos, V
   Leaper, D
AF Lioupis, Christos
   Kotsis, Thomas
   Barbatis, Calypso
   Seretis, Eleni
   Nomikos, Alexandros
   Volondakis-Baltatzis, Irene
   Papalois, Apostolos
   Andrikopoulos, Vasilios
   Leaper, David
TI The Effect of Negative Pressure Therapy on the Femoral Vein Blood Flow
   and Wall Structure
SO ANGIOLOGY
LA English
DT Article
DE negatine pressure therapy; VAC therapy; vacuum-assisted closure;
   deep-vein thrombosis; femoral veins; pigs; hemodynamic effects;
   thrombogenicity
ID VACUUM-ASSISTED CLOSURE; SEQUENTIAL PNEUMATIC COMPRESSION; DEEP VENOUS
   THROMBOSIS; MUSCLE FLAP COVERAGE; GRAFT INFECTIONS; GROIN; PROPHYLAXIS;
   MANAGEMENT; STASIS; INJURY
AB Negative pressure therapy has been recently used for managing lymphatic or infective groin complications. The aim of this study was to investigate any possible association between application of negative pressure therapy in the groin area and deep-vein thrombosis. Acute surgical wounds were created at the inguinal areas in 7 pigs. Different negative pressures ranging from -50 to -200 mmHg were applied directly over the femoral vessels, and blood flow alterations were studied using a Doppler ultrasound. Femoral vein specimens were also removed for histological examination after 12 hours of therapy, It has been demonstrated that negative pressure therapy does not significantly alter the baseline lower limb venous return. Histology demonstrated several changes, which are associated with vein thrombogenesis. The hemodynamic and pathological findings still leave a potential for thrombogenic effects of negative pressure therapy and warrant care to protect the femoral veins, with the use of thrombosis prophylaxis measures.
C1 [Lioupis, Christos; Kotsis, Thomas; Andrikopoulos, Vasilios] Red Cross Hosp Athens, Dept Vasc Surg, Athens, Greece.
   [Barbatis, Calypso; Nomikos, Alexandros] Red Cross Hosp Athens, Dept Histopathol, Athens, Greece.
   [Seretis, Eleni; Volondakis-Baltatzis, Irene] St Savas Anticanc Hosp, Dept Electron Microscopy, Athens, Greece.
   [Papalois, Apostolos] Elpen Pharmaceut, Expt Res Ctr, Athens, Greece.
   [Leaper, David] Cardiff Univ, Wound Healing Res Unit, Cardiff, S Glam, Wales.
C3 Cardiff University
RP Lioupis, C (通讯作者)，59 Dimokratias St, Athens 17563, Greece.
EM christoslioupis@yahoo.gr
OI Lioupis, Christos/0000-0001-6197-3218
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NR 39
TC 2
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
J9 ANGIOLOGY
JI Angiology
PD JUN-JUL
PY 2009
VL 60
IS 3
BP 290
EP 300
DI 10.1177/0003319708318376
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 464MY
UT WOS:000267510400004
PM 18504262
DA 2026-07-24
ER

PT J
AU Ford, CN
   Reinhard, ER
   Yeh, D
   Syrek, D
   de las Morenas, A
   Bergman, SB
   Williams, S
   Hamori, CA
AF Ford, CN
   Reinhard, ER
   Yeh, D
   Syrek, D
   de las Morenas, A
   Bergman, SB
   Williams, S
   Hamori, CA
TI Interim analysis of a prospective, randomized trial of vacuum-assisted
   closure versus the healthpoint system in the management of pressure
   ulcers
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT COonference on Cosmetic Surgery: Applying Techniques and Technology in
   Your Practice
CY JUL 01-08, 2002
CL HOLLAND, ALABAMA
ID SORES
AB Twenty-eight patients with 41 full-thickness decubitus ulcers were randomized to compare the Vacuum-Assisted Closure device (VAC) with the Healthpoint System (HP) of wound gel products in promoting ulcer healing. A total of 22 patients with 35 full-thickness ulcers completed the 6-week trial of treatment, during which time 2 patients (10%) in the VAC group (N = 20) and 2 patients (13%) in the HIP group (N = 15) healed completely. The mean percent reduction in ulcer volume was 42.1% with HIP and 51.8% with VAC (P = 0.46). The mean number of PMNs and lymphocytes per high-power field decreased in the VAC group and increased in the HIP group (p = 0.13, p = 0.41 respectively). The mean number of capillaries per high-power field was greater in the VAC group (p = 0.75). There were 15 cases of biopsy-proven osteomyelitis underlying the ulcers; three (37.5%) improved with VAC and none improved with HP (p = 0.25). VAC promotes an increased rate of wound healing and favorable histological changes in soft tissue and bone compared with HP.
C1 Boston Univ, Sch Med, Boston, MA 02215 USA.
C3 Boston University
RP Hamori, CA (通讯作者)，95 Tremont St,Suite 28, Duxbury, MA 02332 USA.
OI Hamori, Christine/0000-0003-0265-5345; De Las Morenas,
   Antonio/0000-0001-9908-4096
CR [Anonymous], 1994, Cost implications of the pressure ulcer treatment guideline
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 13
TC 146
Z9 168
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUL
PY 2002
VL 49
IS 1
BP 55
EP 61
DI 10.1097/00000637-200207000-00009
PG 7
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 570ZJ
UT WOS:000176690100015
PM 12142596
DA 2026-07-24
ER

PT J
AU Dickie, SR
   Dorafshar, AH
   Song, DH
AF Dickie, Sara R.
   Dorafshar, Amir H.
   Song, David H.
TI Definitive closure of the infected median sternotomy wound - A treatment
   algorithm utilizing vacuum-assisted closure followed by rigid plate
   fixation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE mediastinitis; sternal wound dehiscence; sternal wound reconstruction;
   sternal plate; VAC; rigid sternal fixation
ID FLAP RECONSTRUCTION; MEDIASTINAL INFECTION; INTERNAL-FIXATION; STERNAL
   NONUNION; HEART SURGERY; MUSCLE FLAPS; COMPLICATIONS; MANAGEMENT;
   DEVICE; BRIDGE
AB Mediastinitis and sternal wound dehiscence are devastating and life-threatening complications of median stemotomy incision. Ten consecutive patients between July 2001 and May 2005 were diagnosed with sternal wound infection and dehiscence following median sternotomy. Patients were managed by precise debridement and wound excision in the operating room and then dressed with vacuum-assisted closure device. Intravenous antibiotics were prescribed for wound and blood culture microbiological sensitivity, When wounds were bacteriologically controlled, patients returned to the operating room for definitive closure using rigid sternal plating. All patients were extubated postoperatively. No patients died. Average total hospital stay was 21 days. The pectoralis advancement flap was exclusively used for soft tissue reconstruction in 7 patients. There were 2 cases of chronic superficial sternal infection requiring plate removal; however, bony union of the sternum was achieved in all patients. This treatment algorithm provides a useful management strategy for patients with complicated median stemotomy.
C1 Univ Chicago Hosp, Plast & Reconstruct Surg Sect, Chicago, IL 60637 USA.
C3 University of Illinois System; University of Chicago; University of
   Chicago Medical Center
RP Song, DH (通讯作者)，Univ Chicago Hosp, Plast & Reconstruct Surg Sect, 5841 S Maryland Ave,MC 6035, Chicago, IL 60637 USA.
EM dsong@surgery.bsd.uchicago.edu
RI Dorafshar, Amir/AAP-2657-2021
OI Dorafshar, Amir/0000-0001-7045-3601
CR Argenta L, 1993, JOINT M WOUND HEAL S
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   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
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   Yuen JC, 1995, ANN PLAS SURG, V35, P585, DOI 10.1097/00000637-199512000-00005
NR 26
TC 13
Z9 14
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2006
VL 56
IS 6
BP 680
EP 685
DI 10.1097/01.sap.0000202825.41069.c3
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 047CN
UT WOS:000237857500019
PM 16721085
DA 2026-07-24
ER

PT J
AU Orgill, DP
   McNulty, AK
AF Orgill, Dennis P.
   McNulty, Amy K.
TI Theoretical and Pre-Clinical Models of Vacuum Assisted Closure
SO SURGICAL INNOVATION
LA English
DT Article
DE biomedical engineering; general surgery; simulation; surgical education
ID PRESSURE WOUND THERAPY; SALINE INSTILLATION
AB Vacuum Assisted Closure (VAC) has changed how physicians treat complex and chronic wounds. For over 20 years, we have studied the mechanism of action of these devices in both an academic based research laboratory and in an industry-based laboratory.We performed a literature review of the theoretical and pre-clinical published studies from the two labs which related to the biomechanics of open pore reticulated polyurethane interfaces.The VAC device applies a direct mechanical interface to the wound surface. The interaction of the foam under suction with the wound surface causes surface deformation and cell stretch. The suction removes fluid from the tissues. There are increases in angiogenesis with better vessel morphology than standard dressings. The effect is dependent on the pore size of the foam, the pressure of application and the waveform of application. Undoubtedly, patient factors such as age, diabetes and radiation affect the response.Pre-clinical studies can help in the design and optimization of mechanical-based wound healing devices. Current work on the effects of these devices on lymphatics and scarring are areas of active investigation.
C1 [Orgill, Dennis P.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA USA.
   [McNulty, Amy K.] 3M Co, Med Solut Div, Res & Dev, St Paul, MN USA.
   [McNulty, Amy K.] 3M Co, Med Solut Div, Ctr 3M, Res & Dev, 270-3A-04, St Paul, MN 55144 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; 3M; 3M
RP McNulty, AK (通讯作者)，3M Co, Med Solut Div, Ctr 3M, Res & Dev, 270-3A-04, St Paul, MN 55144 USA.
EM akmcnulty@mmm.com
RI Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310; McNulty, Amy/0000-0001-6656-3103
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 15
TC 2
Z9 2
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD AUG
PY 2023
VL 30
IS 4
BP 533
EP 537
DI 10.1177/15533506221142690
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA O4BZ3
UT WOS:001043297700017
PM 36446390
DA 2026-07-24
ER

PT J
AU Niu, XF
   Yi, JH
   Zha, GQ
   Hu, J
   Liu, YJ
   Xiao, LB
AF Niu, X. -F.
   Yi, J. -H.
   Zha, G. -Q.
   Hu, J.
   Liu, Y. -J.
   Xiao, L. -B.
TI Vacuum sealing drainage as a pre-surgical adjunct in the treatment of
   complex (open) hand injuries: Report of 17 cases
SO ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; Pre-surgical adjunct; Complex (open) hand
   injuries; Wound preparation
ID PRESSURE WOUND THERAPY; SOFT-TISSUE DEFECTS; ASSISTED CLOSURE; COST
AB Background: Few studies have been conducted to explore the use of the vacuum sealing drainage (VSD) technique in complex hand injuries. The aim of this study was to report outcomes in patients with complex hand injuries receiving VSD as a coadjuvant treatment prior to second-stage surgery.
   Methods: This case series study retrospectively reviewed the patients who underwent VSD for treatment of hand injuries. Inclusion criteria for the study were: (1) traumatic soft tissue defects of the hand and wrist, accompanied by different degrees of injury and exposure of bone, tendon, or blood vessel; (2) the wound surface of hand and wrist was seriously contaminated and direct wound closure was not possible; and (3) the soft tissues of hand and wrist were seriously lacerated or avulsed, and showed necrosis or acute infection. After debridement, one-stage and/or two-stage repairs using healthy adjacent tissues were performed and the wound was covered by the VSD materials. The non-cytotoxic polyethylene alcohol hydration seaweed salt foam was applied during the VSD treatment for its good biocompatibility. The drainage tube was connected to the vacuum equipment and the negative pressures were set at -60 kPa to -40 kPa. The VSD device was left in place for 5 to 7 days before removal. Either free skin grafting or skin flap transplantation was used for wound closure and/or reconstructive surgery. The hand injury severity score was used to assess wound severity. The surgical results were scored using the total active motion classification.
   Results: A total of 17 patients (13 and 4 patients had major and severe hand injuries), averaging 33.8 years were included. During the study period, 6 patients with severe hand injuries were not treated with VSD for the following reasons: (1) hemodynamic instability (n = 1); (2) impaired coagulation function (n = 1); (3) uncontrollable hemorrhage on the wound surface (n = 2); and (4) exposure of the main blood vessels after surgical repair (n = 2). VSD treatment was performed for an average of 7.4 days (range, 6-14 days) and the duration of wound healing averaged 23 days (range, 20-43 days). Wound infection was not reported prior to second-stage surgery. Only one of 17 patients had superficial necrosis at the flap edge, for a success rate of 94%. Average follow-up was 8.7 months (range, 4-13 months). Twelve (71%) patients reported excellent or good, four (23%) reported fair, and one (6%) reported poor results.
   Conclusion: The VSD can effectively promote safe and rapid repair of local soft tissues with good prognosis. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Niu, X. -F.; Yi, J. -H.; Zha, G. -Q.; Hu, J.; Liu, Y. -J.; Xiao, L. -B.] Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Dept Upper Extrem Orthoped, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Xiao, LB (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Dept Upper Extrem Orthoped, Guangzhou 510080, Guangdong, Peoples R China.
EM gz20080316@163.com
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NR 24
TC 13
Z9 25
U1 0
U2 10
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1877-0568
J9 ORTHOP TRAUMATOL-SUR
JI Orthop. Traumatol.-Surg. Res.
PD MAY
PY 2017
VL 103
IS 3
BP 461
EP 464
DI 10.1016/j.otsr.2017.01.008
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ET6TK
UT WOS:000400425100026
PM 28274882
DA 2026-07-24
ER

PT J
AU Laimer, J
   Steinmassl, O
   Hechenberger, M
   Rasse, M
   Pikula, R
   Bruckmoser, E
AF Laimer, Johannes
   Steinmassl, Otto
   Hechenberger, Martin
   Rasse, Michael
   Pikula, Rajmond
   Bruckmoser, Emanuel
TI Intraoral Vacuum-Assisted Closure Therapy-A Pilot Study in
   Medication-Related Osteonecrosis of the Jaw
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; BISPHOSPHONATE-RELATED OSTEONECROSIS; TOOTH
   EXTRACTION; MANAGEMENT; ASSOCIATION; FOUNDATION; EXPERIENCE; SURGERY;
   SKIN
AB Purpose: For approximately 2 decades, vacuum-assisted closure (VAC) therapy has been widely used for the management of complex wounds and soft tissue defects on the external surface of the body. As yet, this technique has not been studied for intraoral wound management. Therefore, this study evaluated the feasibility, safety, and effectiveness of intraoral VAC therapy in patients with medication-related osteonecrosis of the jaw (MRONJ).
   Patients and Methods: After successful construction of an intraoral device providing sufficient airtight sealing, individually manufactured appliances were used in a prospective clinical trial of 3 patients using the VAC therapy system.
   Results: Intraoral VAC therapy showed some success and did not produce serious side effects. Different positive effects, such as formation of new granulation tissue, cessation of pain, and pus suppuration, were found.
   Conclusion: This prospective proof-of-principle study showed that intraoral VAC therapy is feasible and safe. It could play a role in the management of MRONJ and other types of intraoral wounds (eg, osteoradionecrosis, postoperative wound dehiscence, etc). (C) 2017 American Association of Oral and Maxillofacial Surgeons
C1 [Laimer, Johannes; Steinmassl, Otto; Hechenberger, Martin; Rasse, Michael; Bruckmoser, Emanuel] Univ Hosp Craniomaxillofacial & Oral Surg, Anichstr 35, A-6020 Innsbruck, Austria.
   [Pikula, Rajmond] Univ Hosp Plast Reconstruct & Aesthet Surg, Innsbruck, Austria.
RP Bruckmoser, E (通讯作者)，Univ Hosp Craniomaxillofacial & Oral Surg, Anichstr 35, A-6020 Innsbruck, Austria.
EM office@bruckmoser.info
FU Medical University Innsbruck, Innsbruck, Austria [EP16200331]
FX Dr Laimer and Dr Bruckmoser are named as inventors of the intraoral
   suctioning device and a request for a grant of a European patent for the
   method of manufacturing this appliance has been submitted by the Medical
   University Innsbruck, Innsbruck, Austria (reference number EP16200331).
   All other authors do not have any relevant financial relationships(s)
   with a commercial interest.
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NR 29
TC 9
Z9 13
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD OCT
PY 2017
VL 75
IS 10
BP 2154
EP 2161
DI 10.1016/j.joms.2017.02.033
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA FM6NZ
UT WOS:000415172000027
PM 28396234
DA 2026-07-24
ER

PT J
AU Filippelli, S
   Perri, G
   Brancaccio, G
   Iodice, FG
   Albanese, SB
   Trimarchi, E
   Carotti, A
AF Filippelli, Sergio
   Perri, Gianluigi
   Brancaccio, Gianluca
   Iodice, Francesca G.
   Albanese, Sonia B.
   Trimarchi, Eugenio
   Carotti, Adriano
TI Vacuum-Assisted Closure System in Newborns After Cardiac Surgery
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID POSTSTERNOTOMY MEDIASTINITIS; WOUND-INFECTION; EXPERIENCE
AB ObjectiveTo analyze the effectiveness and the results of the use of a vacuum-assisted closure (VAC) system for the treatment of complex sternal wounds in newborns after cardiac surgery.
   MethodsFrom May 2008 until December 2012, six patients developed post-sternotomy wound problems (large defects of epithelialization or mediastinitis), which were treated with a VAC system. Median age at the time of institution of VAC was 24.5 days (range 16 to 65 days). Median time of treatment was 14 days (range 3 to 42 days).
   ResultsAll patients were newborns and all underwent delayed sternal closure after cardiac surgery. The indications for using the VAC system were: mediastinitis in two patients (33.3%) and impairment of healing without signs of infection in four (66.7%). All children after VAC therapy achieved healing of the sternal wound. VAC therapy was started with high negative pressures (-125mmHg) continuously then switched to an intermittent modality in all patients.
   ConclusionVAC system with high negative pressure is safe, effective, and is a well-tolerated therapy in newborns with complex sternal wounds. doi: 10.1111/jocs.12463 (J Card Surg 2015;30:190-193)
C1 [Filippelli, Sergio; Perri, Gianluigi; Brancaccio, Gianluca; Iodice, Francesca G.; Albanese, Sonia B.; Carotti, Adriano] Bambino Gesu Pediat Hosp, IRCCS, Dept Pediat Cardiol & Cardiac Surg, I-00165 Rome, Italy.
   [Trimarchi, Eugenio] San Vincenzo Hosp, Pediat Cardiac Surg Unit, Taormina, Italy.
C3 IRCCS Bambino Gesu
RP Perri, G (通讯作者)，Bambino Gesu Pediat Hosp, IRCCS, Dept Pediat Cardiac Surg, Piazza S Onofrio 4, I-00165 Rome, Italy.
EM dr.gianluigiperri@gmail.com
RI Carotti, Adriano/AAR-8567-2021
OI Iodice, Francesca Giovanna/0000-0002-0478-619X; Perri,
   Gianluigi/0000-0002-3787-0873; brancaccio, gianluca/0000-0001-8113-6513;
   Albanese, Sonia/0000-0002-9064-6651
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   Brancaccio G, 2010, J CARDIOVASC MED
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NR 18
TC 6
Z9 9
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD FEB
PY 2015
VL 30
IS 2
BP 190
EP 193
DI 10.1111/jocs.12463
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CA4UO
UT WOS:000348901200013
PM 25363601
DA 2026-07-24
ER

PT J
AU Mokhtari, A
   Sjögren, J
   Nilsson, J
   Gustafsson, R
   Malmsjö, M
   Ingemansson, R
AF Mokhtari, Arash
   Sjogren, Johan
   Nilsson, Johan
   Gustafsson, Ronny
   Malmsjo, Malin
   Ingemansson, Richard
TI The cost of vacuum-assisted closure therapy in treatment of deep sternal
   wound infection
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE health economics; health policy; mediastinitis; wound closure; CABG;
   sternum
ID BYPASS GRAFT-SURGERY; LONG-TERM SURVIVAL; CARDIAC-SURGERY;
   POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS; COMPLICATIONS; SYSTEM;
   IMPACT
AB Objectives. Surgical sites infections are very expensive and the total costs for coronary artery bypass grafting (CABG) surgery followed by deep sternal wound infection (DSWI) with conventional therapy are estimated to be 2.8 times that for normal, CABG surgery. Promising results have been reported with vacuum-assisted closure (VAC) therapy in patients with DSWI. This study presents the cost of VAC therapy in patients with DSWI after CABG surgery. Design. Thirty-eight CABG patients with DSWI, between 2001 and 2005, were treated with VAC therapy. The cost of surgery, intensive care, ward care, laboratory tests and other costs were analyzed. Results. No three-month mortality or recurrent infection was observed. The average cost of CABG procedure and treatment of DSWI was 2.5 times higher than the mean cost of CABG alone. No significant correlations were found between the preoperative EuroSCORE and the cost of DSWI therapy. Conclusions. VAC therapy for patients who underwent CABG surgery followed by DSWI seems to be cost effective, and has low mortality rate.
C1 [Mokhtari, Arash; Sjogren, Johan; Nilsson, Johan; Gustafsson, Ronny; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Mokhtari, A (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
EM arash.mokhtari@med.lu.se
RI Sjögren, Johan/AAZ-6448-2021; Nilsson, Johan/A-4742-2011
OI Maljö, Malin/0000-0001-9849-9599; Nilsson, Johan/0000-0001-6860-6090;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 21
TC 36
Z9 41
U1 0
U2 2
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2008
VL 42
IS 1
BP 85
EP 89
DI 10.1080/14017430701744469
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 262BB
UT WOS:000253122900011
PM 18273735
OA Bronze
DA 2026-07-24
ER

PT J
AU Pliakos, I
   Papavramidis, TS
   Michalopoulos, N
   Deligiannidis, N
   Kesisoglou, I
   Sapalidis, K
   Papavramidis, S
AF Pliakos, Ioannis
   Papavramidis, Theodossis S.
   Michalopoulos, Nick
   Deligiannidis, Nickolaos
   Kesisoglou, Isaak
   Sapalidis, Konstantinos
   Papavramidis, Spiros
TI The Value of Vacuum-Assisted Closure in Septic Patients Treated with
   Laparostomy
SO AMERICAN SURGEON
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; WOUND CLOSURE; TEMPORARY CLOSURE;
   FASCIAL CLOSURE; SILO CLOSURE; WALL; MESH; EXPERIENCE; MANAGEMENT;
   SANDWICH
AB The ideal method of temporary abdominal closure (TAC) should allow rapid closure, easy maintenance, and wound repair with minimal tissue damage. The aim of this retrospective study is to compare open abdomen outcomes between patients managed with vacuum-assisted closure (VAC), and patients managed with other methods of TAC, when septic abdomen is present. Two groups of patients with septic open abdomen: 27 treated with VAC versus 31 treated with other techniques of TAC. We studied open abdomen duration, number of dressing changes, re-exploration rate, successful abdominal closure rate, overall mortality, and development of enteroatmospheric fistulas. The VAC device demonstrated its superiority concerning open abdomen duration (P < 0.001), number of dressing changes (P < 0.001), re-exploration rate (P < 0.002), successful abdominal closure rate (P < 0.0001), and development of enteroatmospheric fistulas (P < 0.00001). Compared with other methods of TAC, our experience with the VAC device demonstrated its advantages concerning clinical feasibility. The high rates of direct fascia closure with an acceptable rate of ventral hernias are further benefits of this technique.
C1 [Pliakos, Ioannis; Papavramidis, Theodossis S.; Michalopoulos, Nick; Deligiannidis, Nickolaos; Kesisoglou, Isaak; Sapalidis, Konstantinos; Papavramidis, Spiros] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Surg 3, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital
RP Papavramidis, TS (通讯作者)，Aigaiou 6, Thessaloniki 54655, Greece.
EM papavramidis@hotmail.com
RI Sapalidis, Konstantinos/AAV-2866-2021; Michalopoulos,
   Nickos/I-6159-2013; Papavramidis, Theodossis/E-8260-2011; Papavramidis,
   Theodossis/E-8260-2011
OI Michalopoulos, Nickos/0000-0002-7740-4922; Papavramidis,
   Theodossis/0000-0002-7097-9889; Papavramidis,
   Theodossis/0000-0002-7097-9889
CR AKERS DL, 1991, J VASC SURG, V14, P48
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NR 29
TC 30
Z9 33
U1 0
U2 8
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD SEP
PY 2012
VL 78
IS 9
BP 957
EP 961
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 101AL
UT WOS:000315747300010
PM 22964204
DA 2026-07-24
ER

PT J
AU Wenzel, AN
   Apel, PJ
   Gosnell, HL
   Grider, DJ
AF Wenzel, Alyssa N.
   Apel, Peter J.
   Gosnell, Hailey L.
   Grider, Douglas J.
TI Fortuitous Eradication of an Aggressive Basal Cell Carcinoma Via Foreign
   Body Reaction to a Polyurethane Vacuum-Assisted Closure Sponge
SO AMERICAN JOURNAL OF DERMATOPATHOLOGY
LA English
DT Article
DE FBR; basal cell carcinoma; aggressive histopathological features;
   positive surgical margins; polyurethane
ID SPONTANEOUS REGRESSION; INFLAMMATORY GRANULOMAS; GIANT-CELLS
AB The foreign body reaction (FBR) is a well-documented immune reaction. Much of the literature on FBRs has focused on minimizing this immune response to mitigate the impact on medical implants. Here, we present a case that illustrates a serendipitous oncologic outcome from an FBR. A 54-year-old man presented with an aggressive basal cell carcinoma (BCC). At the first resection, he had broadly positive surgical margins. The surgical wound was temporized with a polyurethane wound vacuum assisted closure (VAC) device. He was lost to follow-up having retained a VAC sponge for a total of 12 weeks. A wide re-resection was performed 7 months after the initial resection. Exhaustive examination of the resected specimen was performed. There was an absence of any BCC, replaced by a widespread chronic FBR to polyurethane VAC sponge particles. This suggests that the foreign body immune response was sufficiently intense to eradicate any remaining BCC. This case illustrates the concept of an FBR as a novel method of local immunotherapy.
C1 [Wenzel, Alyssa N.; Apel, Peter J.; Gosnell, Hailey L.; Grider, Douglas J.] Virginia Tech, Carilion Sch Med, 2 Riverside Circle, Roanoke, VA 24016 USA.
   [Apel, Peter J.] Carilion Clin, Dept Orthopaed Surg, Roanoke, VA USA.
   [Grider, Douglas J.] Dominion Pathol Associates, Roanoke, VA USA.
C3 Virginia Polytechnic Institute & State University
RP Wenzel, AN (通讯作者)，Virginia Tech, Carilion Sch Med, 2 Riverside Circle, Roanoke, VA 24016 USA.
EM awenzel5@vt.edu
OI Gosnell, Hailey/0000-0003-4952-2689
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0193-1091
EI 1533-0311
J9 AM J DERMATOPATH
JI Am. J. Dermatopathol.
PD OCT
PY 2021
VL 43
IS 10
BP 740
EP 745
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ZA7IC
UT WOS:000756331900016
PM 33534210
DA 2026-07-24
ER

PT J
AU Olona, C
   Duque, E
   Caro, A
   Jiménez, A
   Moreno, F
   Coronas, JM
   Vicente, V
AF Olona, Carles
   Duque, Enric
   Caro, Aleidis
   Jimenez, Andrea
   Moreno, Felix
   Coronas, Jose M.
   Vicente, Vicente
TI Negative-Pressure Therapy in the Postoperative Treatment of Incisional
   Hernioplasty Wounds: A Pilot Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative pressure therapy; incisional hernioplasty; seroma
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; OPEN ABDOMEN; REPAIR; WALL;
   EXPERIENCE; MANAGEMENT; MECHANISMS; MESH
AB Negative pressure therapy has proven useful in the treatment of the complex complications of surgical wounds. In this pilot study, the authors found that the negative pressure system can be used safely in the postoperative period of incisional hernia surgery and reduces the number of days of drainage.
C1 [Olona, Carles; Duque, Enric; Jimenez, Andrea; Moreno, Felix; Coronas, Jose M.; Vicente, Vicente] Joan XXIII Univ Hosp, Gen & Digest Surg Dept, Tarragona, Spain.
   [Caro, Aleidis] Parc Tauli Univ Hosp, Gen & Digest Surg Dept, Sabadell, Spain.
C3 Autonomous University of Barcelona; Parc Tauli Hospital Universitari
RP Olona, C (通讯作者)，Joan XXIII Univ Hosp, Gen & Digest Surg Dept, Tarragona, Spain.
RI ; JimenezFranco, Andrea/PCR-9372-2025; Vicente, Vicente/L-6185-2019
OI Caro, Aleidis/0000-0001-6151-3879; Vicente, Vicente/0000-0002-4278-3264
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NR 23
TC 19
Z9 20
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2014
VL 27
IS 2
BP 77
EP 80
DI 10.1097/01.ASW.0000442873.48590.b5
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AG4KE
UT WOS:000335387600006
PM 24440865
DA 2026-07-24
ER

PT J
AU Kumar, N
   Thompson, CC
AF Kumar, Nitin
   Thompson, Christopher C.
TI Endoscopic Management of Complications After Gastrointestinal Weight
   Loss Surgery
SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Weight Loss; Gastric Bypass; NSAIDs; Endoscopic Ultrasound
ID Y GASTRIC BYPASS; VERTICAL-BANDED GASTROPLASTY; LAPAROSCOPIC SLEEVE
   GASTRECTOMY; HELICOBACTER-PYLORI INFECTION; VACUUM-ASSISTED CLOSURE;
   ANAL FISTULA PLUG; TERM-FOLLOW-UP; BARIATRIC SURGERY; MORBID-OBESITY;
   MARGINAL ULCERATION
AB As more patients undergo bariatric surgery, gastroenterologists will increasingly encounter variant postsurgical anatomies and postoperative complications. We discuss the diagnosis and management of bleeding, ulcers, foreign bodies, stenoses, leaks, fistulas, pancreaticobiliary diseases, weight regain, and dilated outlets.
C1 [Kumar, Nitin; Thompson, Christopher C.] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Kumar, N (通讯作者)，Brigham & Womens Hosp, Div Gastroenterol, 75 Francis St, Boston, MA 02115 USA.
EM nitinkumar.101@gmail.com
RI Kumar, Nitin/E-1320-2016
OI Kumar, Nitin/0000-0002-9876-2884
FU Bard; Boston Scientific; Covidien; USGI Medical; Valentx
FX This author discloses the following: Christopher C. Thompson: Bard:
   consultant (consulting fees)/Bariatric Advisory Board member (travel and
   attendance fees)/licensing agreement/research support (grants); Boston
   Scientific: consultant (consulting fees); Covidien: consultant
   (consulting fees)/Endoluminal Advisory Board member (travel and
   attendance fees); USGI Medical: consultant (consulting fees)/Advisory
   Board member (travel and attendance fees); Valentx: consultant
   (consulting fees); Olympus: lab support (lab supplies/equipment),
   consultant; Vysera: consultant, lab support; Beacon Endoscopic:
   consultant/stock; Apollo Endosurgery: consultant; and Barosense:
   consultant. The remaining author discloses no conflicts.
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NR 138
TC 39
Z9 44
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1542-3565
EI 1542-7714
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD APR
PY 2013
VL 11
IS 4
BP 343
EP 353
DI 10.1016/j.cgh.2012.10.043
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 123TK
UT WOS:000317413700008
PM 23142331
OA Bronze
DA 2026-07-24
ER

PT J
AU Popov, AF
   Schmitto, JD
   Tirilomis, T
   Bireta, C
   Coskun, KO
   Mokashi, SA
   Emmert, A
   Friedrich, M
   Wiese, CH
   Schoendube, FA
AF Popov, Aron F.
   Schmitto, Jan D.
   Tirilomis, Theodor
   Bireta, Christian
   Coskun, Kasim O.
   Mokashi, Suyog A.
   Emmert, Alexander
   Friedrich, Martin
   Wiese, Christoph H.
   Schoendube, Friedrich A.
TI Daptomycin as a possible new treatment option for surgical management of
   Methicillin-Resistant Staphylococcus aureus sternal wound infection
   after cardiac surgery
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID ARTERY-BYPASS GRAFT; COMPLICATED SKIN; MEDIASTINITIS; MICROBIOLOGY;
   ENDOCARDITIS; BACTEREMIA; VANCOMYCIN; THERAPY; CLOSURE; STAY
AB We present a case of a 77-year old female who had undergone a coronary artery bypass grafting with an aortic valve replacement and developed three month later a Methicillin-Resistant Staphylococcus aureus (MRSA) sternal wound infection which was successful treated with Daptomycin combined with vacuum-assisted closure (VAC).
C1 [Popov, Aron F.; Schmitto, Jan D.; Tirilomis, Theodor; Bireta, Christian; Coskun, Kasim O.; Emmert, Alexander; Friedrich, Martin; Schoendube, Friedrich A.] Univ Gottingen, Dept Thorac & Cardiovasc Surg, D-3400 Gottingen, Germany.
   [Schmitto, Jan D.; Mokashi, Suyog A.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiac Surg,Dept Surg, Boston, MA USA.
   [Wiese, Christoph H.] Univ Gottingen, Dept Anaesthesiol Emergency & Intens Care Med, D-3400 Gottingen, Germany.
C3 University of Gottingen; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   University of Gottingen
RP Popov, AF (通讯作者)，Univ Gottingen, Dept Thorac & Cardiovasc Surg, D-3400 Gottingen, Germany.
EM Popov@med.uni-goettingen.de
RI Popov, Aron-Frederik/AAA-9933-2020; Friedrich, Martin/ONJ-5248-2025;
   Schmitto, Jan/AAC-6811-2020; Tirilomis, Theodor/AEP-0737-2022
OI Schmitto, Jan/0000-0002-0344-1405; 
FU Department of Thoracic Cardiovascular Surgery, University of Gottingen,
   Germany
FX The project was supported by a grant from the Department of Thoracic
   Cardiovascular Surgery, University of Gottingen, Germany. The authors
   gratefully thank Mrs. D. Sitte for her expert assistance at wound
   treatment.
CR Fowler VG, 2006, NEW ENGL J MED, V355, P653, DOI 10.1056/NEJMoa053783
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NR 17
TC 6
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 6
PY 2010
VL 5
AR 57
DI 10.1186/1749-8090-5-57
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 656ME
UT WOS:000282338800001
PM 20691034
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Durai, R
   Ng, PCH
AF Durai, R.
   Ng, P. C. H.
TI Novel combination Combining J-VAC® and VAC® sponge for draining a rectal
   wound
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Rectal wound; VAC; negative pressure therapy: stapled haemorrhoidectomy
ID ANASTOMOTIC LEAKAGE; SEPSIS
AB Active drains, which work by negative pressure, require a closed space for retaining the vacuum. Here the authors describe their novel technique of combining a J-Vac (R) drain and the sponge of a vacuum assisted closure dressing pack to drain a rectal wound. This modification may be useful for rectal wounds and anastomotic leaks.
C1 [Durai, R.; Ng, P. C. H.] Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
C3 University of London; King's College London
RP Durai, R (通讯作者)，Univ Hosp Lewisham, Dept Surg, London SE13 6LH, England.
EM dr_durai@yahoo.com
CR Durai R, 2009, TECH COLOPROCTOL, V13, P307, DOI 10.1007/s10151-009-0503-5
   McCloud JM, 2006, COLORECTAL DIS, V8, P748, DOI 10.1111/j.1463-1318.2006.01028.x
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
   Nagell CF, 2006, INT J COLORECTAL DIS, V21, P657, DOI 10.1007/s00384-005-0083-4
   Van Koperen PJ, 2008, COLORECTAL DIS, V10, P943, DOI 10.1111/j.1463-1318.2008.01485.x
   Weidenhagen R, 2008, Rozhl Chir, V87, P397
NR 6
TC 1
Z9 1
U1 0
U2 1
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD JUN
PY 2010
VL 110
IS 3
BP 402
EP 404
DI 10.1080/00015458.2010.11680646
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 625GU
UT WOS:000279884100033
PM 20690536
DA 2026-07-24
ER

PT J
AU Jia, YC
   Shi, YH
AF Jia, Yanchun
   Shi, Yuhong
TI CLINICAL EXPLORATION OF VACUUM SEALING DRAINAGE IN WOUNDS OF SOFT TISSUE
   DEFECTS OF EXTREMITIES
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE VSD; soft tissue defects of extremities; clinical research
ID FLAP; THERAPY; ARTERY
AB Objective: The application of vacuum sealing drainage (VSD) nursing technology in wounds of soft tissue defects of extremities is discussed from various aspects. It seeks a nursing method that can prevent and reduce tube blockage, restore skin tissue, increase patient comfort, reduce treatment costs, and shorten hospital stay, and provide more ideal conditions for subsequent surgical treatment.
   Method: Patients were selected in Tangshan Gongren Hospital from June 2016 to June 2017 as subjects. Patients admitted to the hospital are randomly divided into four groups. Channel establishment and oxygen supply group (group 1): establish a negative pressure closed drainage channel and supply a local intermittent high concentration of oxygen; channel establishment group (group 2): establish a negative pressure closed drainage channel; oxygen supply group (group 3): supply negative pressure closed drainage intermittent high concentration oxygen; control group (group 4): routine care with simple negative pressure closed drainage. The differences and effects of each group in clogging the pipeline, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay are analyzed. Observe the response of the subjects after each experiment. That is, the number of cases of complications such as massive bleeding, post-debridement local infection, exposed bone and tendon degeneration, necrosis, and the number of cases in which no complications occurred during the treatment. The data of this experiment are statistically described and statistically inferred by SPSS17.0 software. The chi-square test is used to compare the count data, and the variance analysis test is used to compare the measurement data.
   Results: by comparison, channel establishment and oxygen supply group are superior to other groups in preventing and reducing tube blockage, restoring skin tissue, increasing patient comfort, reducing treatment costs, and shortening hospital stay.
   Conclusion: VSD care technology may be a new approach to the treatment of soft tissue defects of extremities. it has extensive clinical application value and promotion significance.
C1 [Jia, Yanchun] Tangshan Gongren Hosp, Community Med Care, Tangshan 063000, Peoples R China.
   [Shi, Yuhong] Tangshan Gongren Hosp, Dept Wound Treatment, 27 Wenhua Rd, Tangshan 063000, Peoples R China.
RP Shi, YH (通讯作者)，Tangshan Gongren Hosp, Dept Wound Treatment, 27 Wenhua Rd, Tangshan 063000, Peoples R China.
EM shiyuhongyh0@126.com
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NR 20
TC 0
Z9 0
U1 0
U2 10
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2019
VL 35
SI 1
BP 491
EP 498
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HN4CC
UT WOS:000460130800011
DA 2026-07-24
ER

PT J
AU Hu, X
   Li, HJ
   Guo, WT
   Xiang, HQ
   Hao, L
   Ai, FR
   Sahu, S
   Li, C
AF Hu, Xin
   Li, Huijian
   Guo, Wenting
   Xiang, Huiqin
   Hao, Liang
   Ai, Fanrong
   Sahu, Souradeep
   Li, Chen
TI Vacuum sealing drainage system combined with an antibacterial jackfruit
   aerogel wound dressing and 3D printed fixation device for infections of
   skin soft tissue injuries
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID COMPOSITE
AB Injuries and infections of skin and soft tissue are commonly encountered in primary health care and are challenging to manage. Vacuum sealing drainage (VSD) is generally used in clinical treatment, but current commercial methods of VSD have some disadvantages, such as easy blockage, nonantibacterial effects, and inconvenient curved surfaces. Herein, we report a functional zinc oxide/jackfruit aerogel (ZnO/JFA) composite material that is ultralight, superabsorbent and antibacterial as a new antibacterial VSD wound dressing. The JFA is carbonized from fresh jackfruit, and the JFA exhibits superhydrophilicity and superabsorbability. The water absorption rate of JFA was up to 1209.39%, and the SBF absorption rate was up to 1384.22%. The water absorption rate of ZnO/JFA was up to 494.47%, and the SBF absorption rate was up to 473.71%. The JFA and ZnO/JFA possess a pipeline structure, which is beneficial for absorbing wound exudates. In addition, surface modification of nanosized ZnO and its effects on antibacterial properties and biocompatibility were performed. When the concentration of ZnO/JFA was 3.125 mg/mL, the survival rate of human fibroblast cells was close to 80%, while the antibacterial rates against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli were up to 99.06%, 75.28% and 93.58%, respectively. Moreover, a 3D printed assisted device was introduced to make the ZnO/JFA wound dressing more attached to the bottom of the wound on a curved surface. An integrated device was formed under the printing mold, and then animal experiments were conducted in vivo. The results showed that a healing rate of almost 100% for infected skin wounds was obtained with this novel VSD device after 14 days, compared to only 79.65% without the VSD device. This novel VSD with a negative pressure suction dressing is beneficial for healing infectious wounds.
C1 [Hu, Xin; Li, Huijian; Hao, Liang; Sahu, Souradeep; Li, Chen] Nanchang Univ, Dept Orthoped Surg, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China.
   [Guo, Wenting; Xiang, Huiqin] Nanchang Univ, Clin Med Sch 2, Nanchang 330006, Jiangxi, Peoples R China.
   [Ai, Fanrong] Nanchang Univ, Sch Mech & Elect Engn, Nanchang 330031, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University
RP Li, C (通讯作者)，Nanchang Univ, Dept Orthoped Surg, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China.
EM 15679191922@163.com
RI hao, liang/NBX-8636-2025; Guo, Wenting/GYQ-5456-2022
FU National Natural Science Foundation of China [31960207]; Key Research
   and Development Projects of Jiangxi Science and Technology Department
   [20181BBG70026]; Youth Science Foundation of Jiangxi Province
   [20202BABL216056]; Foundation of Jiangxi Provincial Department of
   Education [1160266]; Hospital Project of The Second Affiliated Hospital
   of Nanchang University [2016YNZJ12007]; Foundation of Health and Family
   Plan-ning Commission of Jiangxi Province [202130487]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 31960207 to FA), Key Research and Development
   Projects of Jiangxi Science and Technology Department(No. 20181BBG70026
   to CL), Youth Science Foundation of Jiangxi Province (No.
   20202BABL216056 to CL), Foundation of Jiangxi Provincial Department of
   Education (No. 1160266 to CL), Hospital Project of The Second Affiliated
   Hospital of Nanchang University (No.2016YNZJ12007 to CL), and Foundation
   of Health and Family Plan-ning Commission of Jiangxi Province (No.
   202130487 to CL)
CR Toledo-Fernández JA, 2008, J MATER SCI-MATER M, V19, P2207, DOI 10.1007/s10856-007-3312-2
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NR 31
TC 14
Z9 15
U1 4
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD DEC 31
PY 2022
VL 34
IS 1
AR 1
DI 10.1007/s10856-022-06709-9
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 7L8PG
UT WOS:000906220300005
PM 36586047
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, MY
   Zhang, HL
   Tang, B
   Fu, J
   Yan, HY
   Luo, HL
AF Zhang, Mingyi
   Zhang, Haolong
   Tang, Bo
   Fu, Jian
   Yan, Haiyan
   Luo, Hailong
TI Outcomes of Covered Stents With Vacuum Sealing Drainage For Treatment of
   Infected Femoral Pseudoaneurysms in Intravenous Drug Addicts
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID ARTERY PSEUDOANEURYSM; MYCOTIC PSEUDOANEURYSMS; MANAGEMENT; ANEURYSMS;
   LIGATION
AB Objective: For treatment of infected femoral artery pseudoaneurysms (IFAPs) with the covered stent, debridement technique is important but frequently ignored. Our study aims to review our experience and outcomes of patients undergoing covered stents placement and debridement with vacuum sealing drainage (VSD).
   Methods: This study retrospectively analyzed 41 intravenous drug addicts with IFAP who received covered stent implantation and debridement with VSD from January 2015 to December 2020. The diagnosis was based on the previous history of local injection and the presence of pulsatile mass at the injection site. All cases were confirmed by CT angiography (CTA), ultrasound, or digital subtraction angiography (DSA). Technical success, time of wound care, and clinical outcomes were evaluated.
   Results: Technical success was achieved in all patients. The interval from diagnosis to treatment was 26 +/- 11 hours. The time of continuous drainage with VSD was 18.79 +/- 6.56 days. 38 patients (92.68%) with fresh granulation tissue were sutured and discharged from the hospital. Stents in 31(91.18%) of 34 cases were patent during follow-ups. Three patients had stent occlusion caused by thrombosis, and two of them were complicated with stent infection. The two infectious stents were removed and the femoral arteries were ligated. One of them received open-surgical reconstruction with the great saphenous because of claudication. Two patients were admitted to the hospital for rebleeding caused by drug abuse relapse.
   Conclusions: Covered stents placement is convenient and rapid to control massive hemorrhage in IFAPs of intravenous drug abuse. Early debridement of infected tissue with continued VSD may shorten the time of wound care and make the incidence of stent infection relatively low. Meanwhile, the patency in a short time follow-up is acceptable. These results indicate that covered stents implantation with VSD may be a safe, effective, and feasible measure for the treatment of IFAPs.
C1 [Zhang, Mingyi; Zhang, Haolong; Tang, Bo; Fu, Jian; Yan, Haiyan; Luo, Hailong] Chongqing Med Univ, Affiliated Hosp 2, Dept Vasc Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
C3 Chongqing Medical University
RP Luo, HL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Vasc Surg, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
EM surgeonhailong@qq.com
RI Luo, Hailong/OYD-5075-2025
CR D'Oria M, 2017, CARDIOVASC INTER RAD, V40, P616, DOI 10.1007/s00270-016-1527-7
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   Gamas L, 2018, EUR J VASC ENDOVASC, V56, P474, DOI 10.1016/j.ejvs.2018.07.037
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   Jayaraman S, 2012, ANN VASC SURG, V26, P819, DOI 10.1016/j.avsg.2011.11.031
   Karkos CD, 2014, TEX HEART I J, V41, P634, DOI 10.14503/THIJ-13-3882
   Lupattelli T, 2009, CARDIOVASC INTER RAD, V32, P347, DOI 10.1007/s00270-008-9401-x
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   Peters S, 2018, HAMOSTASEOLOGIE, V38, P166, DOI 10.5482/HAMO-17-01-0006
   Quiroga E, 2021, J VASC SURG, V73, P635, DOI 10.1016/j.jvs.2020.05.074
   Samarakoon LB, 2021, SINGAP MED J, V62, P135, DOI 10.11622/smedj.2020011
   Stolt M, 2018, VASA, V47, P177, DOI 10.1024/0301-1526/a000691
   Tan KK, 2009, WORLD J SURG, V33, P1830, DOI 10.1007/s00268-009-0123-2
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   Xu J, 2018, MOL MED REP, V17, P4460, DOI 10.3892/mmr.2018.8431
NR 20
TC 3
Z9 4
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2022
VL 81
BP 300
EP 307
DI 10.1016/j.avsg.2021.09.029
EA APR 2022
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 2Q9DG
UT WOS:000820716300037
PM 34780965
DA 2026-07-24
ER

PT J
AU Feng, B
   Li, Z
   Feng, C
   Zeng, A
   Gao, P
   Liu, Y
   Weng, XS
AF Feng, Bin
   Li, Zeng
   Feng, Cheng
   Zeng, Ang
   Gao, Peng
   Liu, Yong
   Weng, Xisheng
TI Early wound complications after orthopaedic surgery for haemophilia:
   What can we do more
SO HAEMOPHILIA
LA English
DT Article
DE early wound complication; haemophilia; risk factors; surgery; vacuum
   sealing drainage
ID EPIDERMAL-GROWTH-FACTOR; TOTAL KNEE REPLACEMENT; SURGICAL-TREATMENT;
   MANAGEMENT; ARTHROPLASTY; ARTHROPATHY; DRAINAGE; RISK
AB Background The characteristics of the haemophilia may endanger the patient with haemophilia (PWH) to higher ratio of wound complication, even lead to the refractory wound problem. The early wound complication in PWH has not been well studied in literature. Methods Between the period from 2002 to 2018, 250 patients underwent 323 elective orthopaedic surgical procedures for the treatment of haemophilic musculoskeletal disorders. The medical records were retrospectively reviewed. The patients were evaluated for postoperative wound complications within 30 days. Risk factors related to wound complications were further analysed. The patients underwent vacuum sealing drainage (VSD) for refractory wound healing problem were further analysed. Results Twenty-four patients of 250 patients experienced early wound complication within postoperative 30 days. The incidence of wound complication in the patients without preoperative infection was 6.5%. Positive inhibitor and surgery for pseudotumour were associated with higher rate of wound complication after logistic regression, with the odds ratios (OR) of 5.7 (95% CI, 1.08 to 30.3) and 4.9 (95% CI, 1.3 to 18.5), respectively. Eight patients underwent VSD treatment for refractory wound healing problem and recovered uneventfully. The total VSD treatment cycle was 2.25 (from 2 to 4). The average factor consumption was 26.1 IU kg(-1) d(-1). The patients complicated with infection had higher, but not statistically significantly, treatment duration, factor consumption and peri-VSD total blood loss than the patients without infection. Conclusions PWH had an incidence of 6.5% of early wound healing problem after elective orthopaedic surgery for musculoskeletal disorder in the present study. The presence of positive inhibitor and surgical procedure for haemophiliac pseudotumour are associated with higher incidence of wound healing problem. The VSD is an effective alternative for the treatment of refractory wound healing problem for PWH, especially for the patients complicated with infection.
C1 [Feng, Bin; Li, Zeng; Gao, Peng; Liu, Yong; Weng, Xisheng] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China.
   [Li, Zeng] South China Univ Technol, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Ctr Orthoped Surg,Sch Med,Div Joint Osteopathy &, Guangzhou, Peoples R China.
   [Feng, Cheng; Zeng, Ang] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Plast Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Southern Medical University - China; South China University of
   Technology; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College Hospital; Peking Union Medical
   College
RP Weng, XS (通讯作者)，Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing 100730, Peoples R China.
EM doctorwxs@163.com
RI /AAT-4908-2020; 冯, 宾/IAR-4784-2023
FU National Natural Science Foundation in China [81871740]
FX This study was supported by a grant from the National Natural Science
   Foundation in China (No. 81871740).
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NR 27
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-8216
EI 1365-2516
J9 HAEMOPHILIA
JI Haemophilia
PD SEP
PY 2020
VL 26
IS 5
BP 882
EP 890
DI 10.1111/hae.14113
EA AUG 2020
PG 9
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA NU0EM
UT WOS:000554335900001
PM 32741019
DA 2026-07-24
ER

PT J
AU Ollat, D
   Vuilletet, E
   Zadegan, F
   Rougereau, G
AF Ollat, Didier
   Vuilletet, Emma
   Zadegan, Frederic
   Rougereau, Gregoire
TI Management of Posterior Digital Skin Defect by Pico Negative Pressure
   Wound Therapy A Case Report and Literature Review
SO ORTHOPAEDIC NURSING
LA English
DT Review
ID HAND; IRRIGATION
AB The use of negative pressure therapy for digital skin loss is uncommon. A reason for this is the difficulty of applying dressings to the hand, which are often difficult to seal. However, negative pressure therapy offers some benefits, especially when associated with local infection. We present a nonspecific, simple and original technique using a Pico negative pressure dressing that may be easily applied in daily practice.
C1 [Ollat, Didier; Vuilletet, Emma; Zadegan, Frederic; Rougereau, Gregoire] Inst Mutualiste Montsouris, Dept Orthoped Surg, 42 Blvd Jourdan, F-75014 Paris, France.
   [Rougereau, Gregoire] Sorbonne Univ, Dept Orthoped & Traumatol, Pitie Salpetriere Hosp, Paris, France.
C3 Universite Paris Cite; Institute Mutualiste Montsouris; Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP
RP Rougereau, G (通讯作者)，Inst Mutualiste Montsouris, Dept Orthoped Surg, 42 Blvd Jourdan, F-75014 Paris, France.
EM Didier.Ollat@imm.fr; emma.vuilletet@gmail.com; frederic.zadegan@imm.fr;
   greg.rougereau@gmail.com
CR Ehrl D, 2018, J BURN CARE RES, V39, P121, DOI 10.1097/BCR.0000000000000557
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   Hasegawa K, 2013, ACTA MED OKAYAMA, V67, P271
   Kasukurthi Rahul, 2010, Hand (N Y), V5, P95, DOI 10.1007/s11552-009-9209-4
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   Lesiak AC, 2013, J HAND SURG-AM, V38A, P1828, DOI 10.1016/j.jhsa.2013.04.029
   Matsushita Y, 2012, J HAND SURG-ASIAN-PA, V17, P71, DOI 10.1142/S0218810412500116
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   Niimi Y, 2017, CLIN MED INSIGHT-CAS, V10, DOI 10.1177/1179547617747279
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NR 15
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0744-6020
EI 1542-538X
J9 ORTHOP NURS
JI Orthop. Nurs.
PD JAN-FEB
PY 2022
VL 41
IS 1
BP 21
EP 24
DI 10.1097/NOR.0000000000000816
PG 4
WC Nursing; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Orthopedics
GA YJ0BD
UT WOS:000744203500006
PM 35045538
DA 2026-07-24
ER

PT J
AU Tuuli, MG
   Liu, JX
   Tita, ATN
   Longo, S
   Trudell, A
   Carter, EB
   Shanks, A
   Woolfolk, C
   Caughey, AB
   Warren, DK
   Odibo, AO
   Colditz, G
   Macones, GA
   Harper, L
AF Tuuli, Methodius G.
   Liu, Jingxia
   Tita, Alan T. N.
   Longo, Sherri
   Trudell, Amanda
   Carter, Ebony B.
   Shanks, Anthony
   Woolfolk, Candice
   Caughey, Aaron B.
   Warren, David K.
   Odibo, Anthony O.
   Colditz, Graham
   Macones, George A.
   Harper, Lorie
TI Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound
   Dressing on Surgical-Site Infection in Obese Women After Cesarean
   Delivery: A Randomized Clinical Trial
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB Surgical-site infection is a significant cause of morbidity, lengthening hospital stays and contributing to health care costs. Cesarean delivery increases the risk of surgical site infection, and obesity contributes to this risk because obese pregnant women are more likely to have cesarean deliveries. Negative pressure wound therapy is becoming more common for wound closure after cesarean delivery. Yet, studies on its effectiveness have been limited to retrospective, cohort studies and randomized trials with small sample sizes. The need for larger, well-designed trials was cited in a 2019 Cochrane review. The aim of this study was to examine the effectiveness of negative pressure wound therapy on the risk of surgical site and other wound infections in obese women who had cesarean deliveries.
   This was a randomized clinical trial, conducted at 4 academic medical centers and 2 community hospitals between February 8, 2007, and December 18, 2019. Included were pregnant women at =23 weeks of gestation with body mass index >= 30, who were undergoing scheduled or unplanned cesarean delivery. Excluded were women who were lost to follow-up or had a contraindication to negative pressure wound therapy. Women were randomized to receive either negative pressure therapy or standard wound dressing for the surgical incision after cesarean delivery. Follow-up occurred via telephone approximately 30 days after delivery to determine if they had symptoms of surgical site infection or had received care for other wound complications.
   A total of 1608 women were included in the analysis. Surgical-site infection, whether superficial or deep, was diagnosed in 29 (3.6%) of the 806 women in the negative pressure group and 27 (3.4%) of the 802 women in the standard dressing group. No significant difference was observed in the risk of surgical site infection between the groups (difference, 0.36%; 95% confidence interval [CI], -1.46% to 2.19%; P = 0.70). Other wound infections were diagnosed in 21 women (2.6%) in the negative pressure group and 35 (3.1%) in the standard dressing group. Again, no significant difference was observed in the risk of other wound infections between the groups (difference, 0.53%; 95% CI, -1.93% to 0.88%; P = 0.46).
   There were also no significant differences between the groups in pain scores at discharge and 30 days postoperative (difference, -0.15% [95% CI, -0.39% to 0.09%; P = 0.23] and difference, 0.02% [95% CI, -0.34% to 0.38%; P = 0.90], respectively). At discharge, women in the negative pressure group reported significantly higher satisfaction than those in the standard dressing group (median [interquartile range], 10 [8-10] vs 9 [7-10]; difference, 0.79; 95% CI, 0.25-1.32; P < 0.001), but at 30 days postoperative, no significant difference between the groups was observed (difference, 0.19; 95% CI, -0.01 to 0.39; P = 0.07). Overall, the risk of serious adverse events was not significantly different between the 2 groups (4 women [0.5%] in the negative pressure group and 5 women [0.6%] in the standard dressing pressure group [difference, -0.13%; 95% CI, -0.86% to 0.60%]). However, the risk of adverse skin reactions-including blisters, bleeding, erythema, and other skin reactions-was significantly higher in the negative pressure group (56 events [7.0%]) compared with the standard dressing group (5 events [0.6%]) (difference, 6.95%; 95% CI, 1.86%-12.03%; P < 0.001).
   The risks of surgical site infection, other wound infections, or pain scores were not significantly reduced in obese women who received prophylactic negative pressure wound therapy after cesarean delivery, compared with those who received standard wound dressing.
C1 [Tuuli, Methodius G.; Shanks, Anthony] Indiana Univ Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA.
   [Liu, Jingxia; Colditz, Graham] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
   [Tita, Alan T. N.; Harper, Lorie] Univ Alabama Birmingham, Dept Obstet & Gynecol, Birmingham, AL USA.
   [Tita, Alan T. N.; Harper, Lorie] Univ Alabama Birmingham, Ctr Womens Reprod Hlth, Birmingham, AL USA.
   [Longo, Sherri] Ochsner Hlth, Dept Obstet & Gynecol, New Orleans, LA USA.
   [Trudell, Amanda] Washington Univ, Sch Med, Div Maternal Fetal Med, BJC Med Grp, St Louis, MO USA.
   [Carter, Ebony B.; Woolfolk, Candice] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
   [Caughey, Aaron B.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Portland, OR 97201 USA.
   [Warren, David K.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Odibo, Anthony O.] Univ S Florida, Dept Obstet & Gynecol, Sch Med, Tampa, FL 33620 USA.
   [Macones, George A.] Univ Texas Austin, Dept Obstet & Gynecol, Dell Sch Med, Austin, TX 78712 USA.
C3 Indiana University System; Indiana University Bloomington; Washington
   University (WUSTL); University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; Washington University (WUSTL); Washington University
   (WUSTL); Oregon Health & Science University; Washington University
   (WUSTL); State University System of Florida; University of South
   Florida; University of Texas System; University of Texas Austin
RP Tuuli, MG (通讯作者)，Indiana Univ Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA.
RI Colditz, Graham/A-3963-2009; Longo, Sherri/G-3969-2011
OI Colditz, Graham/0000-0002-7307-0291; Warren, David/0000-0001-8679-8241; 
NR 0
TC 0
Z9 0
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD FEB
PY 2021
VL 76
IS 2
BP 75
EP 77
DI 10.1097/01.ogx.0000733472.05507.88
PG 3
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA QL2MG
UT WOS:000620913600005
DA 2026-07-24
ER

PT J
AU Fernández, LG
   Matthews, MR
   Ellman, C
   Jackson, P
   Villarreal, DH
   Norwood, S
AF Fernandez, Luis G.
   Matthews, Marc R.
   Ellman, Cynthia
   Jackson, Patricia
   Villarreal, David H.
   Norwood, Scott
TI Use of Reticulated Open Cell Foam Dressings With Through Holes During
   Negative Pressure Wound Therapy With Instillation and Dwell Time: A
   Large Case Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time;
   reticulated open cell foam dressing with through holes; complex wounds;
   wound healing
AB Introduction. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) has been utilized in wounds with positive clinical benefits. A reticulated open cell foam dressing with through holes (ROCF-CC) was developed to assist with wound cleansing by removing thick wound exudate and infectious materials, and it may be used when debridement is not possible or appropriate. Use of NPWTi-d with ROCF-CC dressings has been reported with positive outcomes in complex wounds. Objective. The present study reports the authors' experience using NPWTi-d with ROCF-CC dressings in 19 patients with complex wounds. Materials and Methods. Of the 19 patients, 8 underwent sharp debridement. Oral and/or intravenous antibiotic treatment was initiated as needed prior to NPWTi-d. All patients received NPWTi-d with ROCF-CC dressings with instillation of quarter-strength Dakin's solution, hypochlorous acid solution, or saline with a dwell time of 5 to 10 minutes, followed by 2 to 3.5 hours of continuous negative pressure at -125 mm Hg. Dressing changes occurred every 2 to 3 days. Measurements and assessments of wound progression were done as per institutional protocols. Results. The 19 treated patients consisted of 10 males and 9 females, with an average age of 58.2 +/- 15.1 years. Common patient comorbidities included hypertension, diabetes, obesity, and paraplegia. Wound types included pressure injuries, traumatic wounds, and surgical wounds. The average length of NPWTi-d use was 9.5 +/- 4.1 days. In all of the patients, the wound beds showed development of healthy granulation tissue following NPWTi-d with ROCF-CC. All patients were discharged to one of the following: another hospital facility, skilled nursing facility, long-term acute care facility, or home. Conclusions. In the authors' clinical practice, NPWTi-d with ROCF-CC provided effective and rapid removal of thick exudate and infectious materials and promoted development of granulation tissue.
C1 [Fernandez, Luis G.; Villarreal, David H.; Norwood, Scott] Univ Texas Tyler, Hlth Sci Ctr, Tyler, TX 75799 USA.
   [Fernandez, Luis G.; Villarreal, David H.; Norwood, Scott] Univ Texas Arlington, Arlington, TX 76019 USA.
   [Matthews, Marc R.] Maricopa Cty Gen Hosp, Arizona Burn Ctr, Phoenix, AZ USA.
   [Ellman, Cynthia; Jackson, Patricia] Christus Trinity Mother Frances Hosp, Tyler, TX USA.
C3 University of Texas System; University of Texas at Tyler; University of
   Texas-Health Sciences Center at Tyler (UTHSCT); University of Texas
   System; University of Texas Arlington; Maricopa County General Hospital
RP Fernández, LG (通讯作者)，Univ Texas Hlth East Texas Phys Tyler Trauma Surg, Dept Surg, 1020 E Idel St, Tyler, TX 75701 USA.
EM thebigkahuna115@gmail.com
RI FERNANDEZ, LUIS/O-7657-2019
CR Blalock L, 2019, WOUNDS, V31, P55
   Fernandez L, 2017, Journal of Trauma & Treatment, V06, DOI [10.4172/2167-1222.1000410, 10.4172/2167-1222.1000410, DOI 10.4172/2167-1222.1000410]
   Gupta S, 2017, WOUNDS, pS19
   Kim Paul J, 2015, Surg Technol Int, V26, P51
   Kim PJ, 2015, Wounds, V27, pS2
   KUCHARZEWSKI M, 2014, BIOMED RES INT, V2014
   McElroy EF, 2019, INT WOUND J, V16, P781, DOI 10.1111/iwj.13097
   Panayi AC, 2017, World Journal of Dermatology, V6, P1, DOI [10.5314/wjd.v6.i1.1, 10.5314/wjd.v6.i1.1, DOI 10.5314/WJD.V6.I1.1]
   Schultz GS, 2003, WOUND REPAIR REGEN, V11, pS1, DOI 10.1046/j.1524-475X.11.s2.1.x
   Snyder RJ, 2016, ADV SKIN WOUND CARE, V29, P205, DOI 10.1097/01.ASW.0000482354.01988.b4
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Wolvos Tom, 2004, Ostomy Wound Manage, V50, P56
NR 12
TC 13
Z9 15
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2020
VL 32
IS 10
BP 279
EP 282
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6PX
UT WOS:000613566600003
PM 33370246
DA 2026-07-24
ER

PT J
AU Obst, MA
   Harrigan, J
   Wodash, A
   Bjurstrom, S
AF Obst, Mary Anne
   Harrigan, Jane
   Wodash, Aaron
   Bjurstrom, Stina
TI Early-stage Management of Complex Wounds Using Negative Pressure Wound
   Therapy With Instillation and a Dressing With Through Holes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Negative pressure wound therapy; instillation; wound management;
   NPWTi-d; open-cell foam dressing; dressings; complex wound; chronic
   wound; necrotizing fasciitis
ID SALINE
AB Introduction. An early-stage decision clinicians often make in the management of complex wounds is which method of wound preparation will be appropriate for the patient. This decision can be affected by numerous wound and patient risk factors that present challenges and may make surgical debridement difficult in patients with complex wounds. Recently, negative pressure wound therapy with instillation and dwell time (NPWTi-d) using a novel reticulated open-cell foam dressing with through holes (ROCF-CC) was shown to aid in the loosening and removal of thick exudate and nonviable tissue from wounds. Objective. The authors present their experiences of using NPWTi-d with ROCF-CC, along with rationales for wound care decisions. Materials and Methods. Patients received antibiotics and surgical debridement when appropriate. Therapy selection and parameters were based on a decision-tree model for wound care management that takes into consideration patient and wound information. Most patients received NPWTi-d with ROCF-CC for a duration of 5 to 8 days; however, 1 patient received NPWTi-d with ROCF-CC for more than 30 days due to the wound extent and severity. Therapy consisted of instilling saline or quarter-strength sodium hypochlorite solution with dwell times of 3 to 10 minutes, followed by 2 hours or 3.5 hours of NPWT either at -100 mm Hg or -125 mm Hg. Results. There were 6 patients (3 men, 3 women; average age, 58.5 years) treated. Wound types included 3 pressure ulcers, 1 necrotizing soft tissue infection, 1 perianal abscess, and 1 large abdominal wound. Patient comorbidities included obesity, type 2 diabetes, and radiation therapy. In all cases, progression of wound healing was observed with no complications. This method produced viable granulation tissue and wound bed preparation; however, patients were not followed to closure or grafting. Conclusions. These cases help support the use of NPWTi-d with ROCF-CC as a viable option for wound care providers in the early-stage management of complex
C1 [Obst, Mary Anne] Reg Hosp, Complex Abdominal Reconstruct Serv, 640 Jackson St, St Paul, MN 55101 USA.
   [Harrigan, Jane; Bjurstrom, Stina] Reg Hosp, Wound & Ostomy Serv, St Paul, MN USA.
   [Wodash, Aaron] Reg Hosp, Orthoped, St Paul, MN USA.
RP Obst, MA (通讯作者)，Reg Hosp, Complex Abdominal Reconstruct Serv, 640 Jackson St, St Paul, MN 55101 USA.
EM maryanneobst@gmail.com
CR Blome-Eberwein S, 2018, Burns Open, V2, P208, DOI [10.1016/j.burnso.2018.05.004, 10.1016/j.burnso.2018.05.004, DOI 10.1016/J.BURNSO.2018.05.004]
   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Fernandez L, 2017, Journal of Trauma & Treatment, V06, DOI [10.4172/2167-1222.1000410, 10.4172/2167-1222.1000410, DOI 10.4172/2167-1222.1000410]
   Gabriel Allen, 2014, Eplasty, V14, pe41
   Gupta S, 2016, INT WOUND J, V13, P159, DOI 10.1111/iwj.12452
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim Paul J, 2015, Surg Technol Int, V26, P51
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2015, Wounds, V27, pS2
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 11
TC 9
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2019
VL 31
IS 5
BP E33
EP E36
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4YS
UT WOS:000484279000003
PM 31184590
DA 2026-07-24
ER

PT J
AU Dumville, JC
   Owens, GL
   Crosbie, EJ
   Peinemann, F
   Liu, ZM
AF Dumville, Jo C.
   Owens, Gemma L.
   Crosbie, Emma J.
   Peinemann, Frank
   Liu, Zhenmi
TI Negative pressure wound therapy for treating surgical wounds healing by
   secondary intention
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE; METAANALYSIS; INFECTIONS;
   SURVIVAL; DISEASE; SURGERY; GROIN
AB Background
   Following surgery, incisions are usually closed by fixing the edges together with sutures (stitches), staples, adhesive glue or clips. This process helps the cut edges heal together and is called 'healing by primary intention'. However, not all incised wounds are closed in this way: where there is high risk of infection, or when there has been significant tissue loss, wounds may be left open to heal from the 'bottom up'. This delayed healing is known as 'healing by secondary intention'. Negative pressure wound therapy (NPWT) is one treatment option for surgical wounds that are healing by secondary intention.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) on the healing of surgical wounds healing by secondary intention (SWHSI) in any care setting.
   Search methods
   For this review, in May 2015 we searched the following databases: the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials; Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations; Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication.
   Selection criteria
   Published or unpublished randomised controlled trials (RCTs) comparing the effects of NPWT with alternative treatments or different types of NPWT in the treatment of SWHSI. We excluded open abdominal wounds from this review as they are the subject of a separate Cochrane review that is in draft.
   Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction.
   Main results
   We located two studies (69 participants) for inclusion in this review. One study compared NPWT with an alginate dressing in the treatment of open, infected groin wounds. and one study compared NPWT with a silicone dressing in the treatment of excised pilonidal sinus. The trials reported limited outcome data on healing, adverse events and resource use.
   Authors' conclusions
   There is currently no rigorous RCT evidence available regarding the clinical effectiveness of NPWT in the treatment of surgical wounds healing by secondary intention as defined in this review. The potential benefits and harms of using this treatment for this wound type remain largely uncertain.
C1 [Dumville, Jo C.; Liu, Zhenmi] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Owens, Gemma L.; Crosbie, Emma J.] Univ Manchester, Inst Canc Sci, Manchester M13 9PL, Lancs, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, Pediat Oncol & Hematol, D-50931 Cologne, Germany.
C3 University of Manchester; University of Manchester; University of
   Cologne
RP Dumville, JC (通讯作者)，Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI ; Liu, Zhenmi/O-7046-2014; Dumville, Jo/O-7867-2014; /H-2800-2019
OI Davidson, Emma/0000-0003-0284-8630; Liu, Zhenmi/0000-0003-0840-1071;
   Owens, Gemma Louise/0000-0003-3471-4370; Dumville,
   Jo/0000-0002-6546-3685; 
FU School of Nursing, Midwifery and Social Work. University of Manchester,
   UK; National Institute for Health Research [13/89/08]; National
   Institute for Health Research [NIHR-CS-012-009, 13/89/08,
   ACF-2012-06-012] Funding Source: researchfish
FX Internal sources School of Nursing, Midwifery and Social Work.
   University of Manchester, UK. External sources This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08 - High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health, UK.
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NR 63
TC 55
Z9 64
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2015
IS 6
AR CD011278
DI 10.1002/14651858.CD011278.pub2
PG 39
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CM3TE
UT WOS:000357606400074
PM 26042534
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Nherera, LM
   Saunders, C
   Verma, S
   Trueman, P
   Fatoye, F
AF Nherera, Leo M.
   Saunders, Chris
   Verma, Sanjay
   Trueman, Paul
   Fatoye, Francis
TI Single-use negative pressure wound therapy reduces costs in closed
   surgical incisions: UK and US economic evaluation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed surgical incisions; cost-effectiveness; diabetes; dressing;
   single-use negative pressure wound therapy; surgical site complications;
   wound; wound healing
ID SITE INFECTION; RISK-FACTORS; OUTCOMES; SURGERY; BYPASS; HEALTH; IMPACT;
   CARE
AB Objective: Single-use negative pressure wound therapy (sNPWT) following closed surgical incisions has a demonstrable effect in reducing surgical site complications (SSC). However, there is little health economic evidence to support its widespread use. We sought to evaluate the cost-effectiveness of sNPWT compared with standard care in reducing SSCs following closed surgical incisions.
   Method: A decision analytic model was developed to explore the total costs and health outcomes associated with the use of the interventions in patients following vascular, colorectal, cardiothoracic, orthopaedic, C-section and breast surgery from the UK National Health Service (NHS) and US payer perspective over a 12-week time horizon. We modelled complications avoided (surgical site infection (SSI) and dehiscence) using data from a recently published metaanalysis. Cost data were sourced from published literature, NHS reference costs and Centers for Medicare and Medicaid Services. We conducted subgroup analysis of patients with diabetes, an American Society of Anesthesiologists (ASA) score >= 3 and body mass index BMI) >= 30kg/m(2). A sensitivity analysis was also conducted.
   Results: sNPWT resulted in better clinical outcomes and overall savings of 105 pound per patient from the UK perspective and $637 per patient from the US perspective. There were more savings when higher-risk patients with diabetes, or a BMI >= 30kg/m(2) or an ASA >= 3 were considered. We conducted both one-way and probabilistic sensitivity analysis, and the results suggested that this conclusion is robust.
   Conclusion: Our findings suggest that the use of sNPWT following closed surgical incisions saves cost when compared with standard care because of reduced incidence of SSC. Patients at higher risk should be targeted first as they benefit more from sNPWT. This analysis is underpinned by strong and robust clinical evidence from both randomised and observational studies. Declaration of interest: LN, CS, SV and PT are employees of Smith + Nephew Inc., and may own shares of Smith + Nephew. FF is a consultant of Smith + Nephew.
C1 [Nherera, Leo M.] Smith Nephew, Ft Worth, TX 76109 USA.
   [Saunders, Chris; Trueman, Paul] Smith Nephew, Global Clin Affairs, Kingston Upon Hull, N Humberside, England.
   [Verma, Sanjay] Smith Nephew, Global Biostat, Watford, England.
   [Fatoye, Francis] Manchester Metropolitan Univ, Hlth Econ & Outcomes, Manchester, Lancs, England.
C3 Smith & Nephew; Smith & Nephew; Manchester Metropolitan University
RP Nherera, LM (通讯作者)，Smith Nephew, Ft Worth, TX 76109 USA.
EM leo.nherera@smith-nephew.com
OI Fatoye, Francis/0000-0002-3502-3953
CR [Anonymous], MED B
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NR 40
TC 12
Z9 16
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2021
VL 30
IS 5
SU S
BP S23
EP S31
DI 10.12968/jowc.2021.30.Sup5.S23
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA SD8HQ
UT WOS:000651616700005
PM 33979232
DA 2026-07-24
ER

PT J
AU Cetinkaya, OA
   Celik, SU
   Boztug, CY
   Uncu, H
AF Cetinkaya, Omer Arda
   Celik, Suleyman Utku
   Boztug, Can Yahya
   Uncu, Hakan
TI Treatment of hard to heal leg ulcers with hyaluronic acid, sodium
   alginate and negative pressure wound therapy
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hyaluronic acid; leg ulcer; negative pressure wound therapy; sodium
   alginate; wound
ID COMBINATION
AB Objective: Hard-to-heal lower extremity ulcer is a common healthcare problem and can lead to a poor quality of life (QoL). Despite the advances in wound care, conventional therapies, such as necrotic tissue debridement, cleansing, treatment of infection and local treatment with dressing application are still considered the standard of care in patients with hard-to-heal leg ulcers. However, managing hard-to-heal ulcers that do not respond well to these methods has led to new treatment strategies. In this study, the effects of hyaluronic acid (HA) and sodium alginate (SA), combined with negative pressure wound therapy (NPWT), in patients with hard-to-heal leg ulcers are evaluated.
   Method: Patients with hard-to-heal lower extremity ulcers were treated with HA-SA combined with NPWT (HA-SA-NWPT, n=11), or conventional therapy (n=14), between June 2014 and September 2015. Demographics, comorbidities, time to complete healing and change in wound area were recorded and compared.
   Results: A total of 25 patients took part. Complete healing was achieved in 63.6% (n=7) of the patients in the HA SA with NPWT group, compared with 14.3% (n=2) of the patients in the conventional therapy group (p=0.017). The mean decrease in wound size was significantly higher in the HA-SA-NPWT group than in the conventional therapy group (73.8% versus 34.8%, respectively, p=0.029). Despite a shorter healing period in the HA-SA-NPWT group than in the conventional group, no statistically significant difference was found between groups for time to complete healing (37 days versus 55 days, respectively).
   Conclusion: These results demonstrate that the combination of HA-SA-NPWT is a promising treatment for decreasing the healing time and increasing the success rate by their synergistic effect on wound healing in hard-to-heal lower extremity ulcers. However, further studies with a larger number of patients are needed to confirm the results.
C1 [Cetinkaya, Omer Arda; Boztug, Can Yahya; Uncu, Hakan] Ankara Univ, Dept Surg, Div Vasc Surg, Sch Med, Ankara, Turkey.
   [Celik, Suleyman Utku] Gulhane Training & Res Hosp, Clin Gen Surg, Ankara, Turkey.
C3 Ankara University; Gulhane Training & Research Hospital
RP Cetinkaya, OA (通讯作者)，Ankara Univ, Dept Surg, Div Vasc Surg, Sch Med, Ankara, Turkey.
EM omerardacetinkaya@yahoo.com
RI Celik, Suleyman Utku/A-4722-2018; /AAI-9984-2020; Boztug, Can
   yahya/HTM-1243-2023
OI Celik, Suleyman Utku/0000-0002-1570-6327; Boztug, Can
   yahya/0000-0001-9980-0873
CR [Anonymous], 2014, REV, DOI DOI 10.1111/OBR.12215
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
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   Frykberg RG, 2015, ADV WOUND CARE, V4, P560, DOI 10.1089/wound.2015.0635
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NR 18
TC 4
Z9 4
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2020
VL 29
IS 7
BP 419
EP 423
DI 10.12968/jowc.2020.29.7.419
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA MN3VX
UT WOS:000550773300007
PM 32654603
DA 2026-07-24
ER

PT J
AU Keeney, JA
   Cook, JL
   Clawson, SW
   Aggarwal, A
   Stannard, JP
AF Keeney, James A.
   Cook, James L.
   Clawson, Stacee W.
   Aggarwal, Ajay
   Stannard, James P.
TI Incisional Negative Pressure Wound Therapy Devices Improve Short-Term
   Wound Complications, but Not Long-Term Infection Rate Following Hip and
   Knee Arthroplasty
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE incisional negative pressure wound therapy; wound healing; wound
   complications; total knee arthroplasty; total hip arthroplasty
ID DRESSINGS; SURGERY
AB Background: The potential value of incisional negative pressure wound therapy (iNPWT) on lower extremity total joint arthroplasty (TJA) wound healing has been supported in a few retrospective studies. We performed this prospective, randomized, controlled trial to assess the impact of iNPWT on wound appearance, early complications, and late infection rates following hip and knee TJA compared with a standard surgical dressing.
   Methods: Three-hundred ninety-eight patients undergoing primary or revision lower extremity TJA were randomized into iNPWT or conventional wound dressing groups. Wound healing and early complication rates were assessed at 7, 14, and 35 days after the index surgery. Late infection rates were determined at a mean 2-year follow-up.
   Results: Patients treated with an iNPWT device were more likely to report wound drainage at day 7 (P =.01), but less drainage longer than 14 days (P =.04). Wound drainage was significantly higher for total hip arthroplasty patients at day 7 (P =.04), but differences were not sustained through the other time intervals. Total knee arthroplasty patients with a body mass index > 35 kg/m(2) treated with an iNPWT device experienced fewer complications (1.3% vs 21.6%, P <.01) and fewer dressing-related concerns (1.3% vs 10.8%, P =.02) compared with a conventional dressing. No significant difference in late superficial or deep infection rates was identified between iNPWT and conventional dressing groups (4.0% vs 3.4%, P =.8).
   Conclusion: Our study findings support improved soft tissue healing response with the use of iNPWT devices. While postoperative wound drainage may limit their value following total hip arthroplasty, incisional NPWT devices may have a targeted benefit for elective total knee arthroplasty patients with a body mass index > 35 kg/m(2). Specific study in this higher-risk patient group may be helpful to define the value of iNPWT. (c) 2018 Elsevier Inc. All rights reserved.
C1 [Keeney, James A.; Cook, James L.; Clawson, Stacee W.; Aggarwal, Ajay; Stannard, James P.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia
RP Keeney, JA (通讯作者)，Univ Missouri, Dept Orthopaed Surg, Grad Med Educ, Adult Hip & Knee Reconstruct Serv, 1100 Virginia Ave, Columbia, MO 65201 USA.
OI Cook, James/0000-0002-0862-995X; Stannard, James P/0000-0001-8467-6494
FU Smith & Nephew Orthopaedics
FX The authors would like to thank Vicki Jones and Kevin Matz for their
   contributions to data collection and analysis. Our institution received
   research funding from Smith & Nephew Orthopaedics that was related to
   this study.
CR Cooper HJ, 2016, J ARTHROPLASTY, V31, P1047, DOI 10.1016/j.arth.2015.11.010
   Jamsen Esa, 2012, J Bone Joint Surg Am, V94, pe101, DOI 10.2106/JBJS.J.01935
   Karlakki S, 2013, BONE JOINT RES, V2, P276, DOI 10.1302/2046-3758.212.2000190
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Manoharan V, 2016, J ARTHROPLASTY, V31, P2487, DOI 10.1016/j.arth.2016.04.016
   Masden D, 2012, ANN SURG, V255, P1043, DOI 10.1097/SLA.0b013e3182501bae
   Nelson CL, 2015, CLIN ORTHOP RELAT R, V473, P3163, DOI 10.1007/s11999-015-4333-7
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   Schwartz JA, 2015, J WOUND CARE S2, V24, P4
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JP, 2012, J ORTHOP TRAUMA, V26, P37, DOI 10.1097/BOT.0b013e318216b1e5
   Tischler EH, 2017, J BONE JOINT SURG AM, V99, P295, DOI 10.2106/JBJS.16.00311
NR 15
TC 42
Z9 44
U1 0
U2 4
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD APR
PY 2019
VL 34
IS 4
BP 723
EP 728
DI 10.1016/j.arth.2018.12.008
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HP4YZ
UT WOS:000461683700020
PM 30612833
DA 2026-07-24
ER

PT J
AU Chetter, I
   Arundel, C
   Martin, BC
   Hewitt, C
   Fairhurst, C
   Joshi, K
   Mott, A
   Rodgers, S
   Goncalves, PS
   Torgerson, D
   Wilkinson, J
   Blazeby, J
   Macefield, R
   Dixon, S
   Henderson, E
   Oswald, A
   Dumville, J
   Lee, M
   Pinkney, T
   Stubbs, N
   Wilson, L
AF Chetter, Ian
   Arundel, Catherine
   Martin, Belen Corbacho
   Hewitt, Catherine
   Fairhurst, Caroline
   Joshi, Kalpita
   Mott, Andrew
   Rodgers, Sara
   Goncalves, Pedro Saramago
   Torgerson, David
   Wilkinson, Jacqueline
   Blazeby, Jane
   Macefield, Rhiannon
   Dixon, Stephen
   Henderson, Eileen
   Oswald, Angela
   Dumville, Jo
   Lee, Matthew
   Pinkney, Thomas
   Stubbs, Nikki
   Wilson, Lyn
TI Negative pressure wound therapy versus usual care for surgical wounds
   healing by secondary intention (SWHSI-2 trial): study protocol for a
   pragmatic, multicentre, cross surgical specialty, randomised controlled
   trial
SO TRIALS
LA English
DT Article
DE Surgical wounds; Negative pressure wound therapy; Secondary intention;
   Wound healing; Randomised controlled trial
ID ALGINATE; CLOSURE
AB Background: The majority of surgical wounds are closed (for example with sutures or staples) and so heal by primary intention. Where closure is not possible, or the wound subsequently breaks down, wounds may be left to heal from the bottom up (healing by secondary intention). Surgical wound healing by secondary intention (SWHSI) frequently presents a significant management challenge. Additional treatments are often required during the course of healing, and thus a significant financial burden is associated with treating these wounds. Increasingly, negative pressure wound therapy (NPWT) is used in the management of SWHSI. This wound dressing system provides a negative pressure (vacuum) to the wound, removing fluid into a canister, which is believed to be conducive to wound healing. Despite the increasing use of NPWT, there is limited robust evidence for the effectiveness of this device. A well-designed and conducted randomised controlled trial is now required to ascertain if NPWT is a clinically and cost-effective treatment for SWHSI.
   Methods: SWHSI-2 is a pragmatic, multi-centre, cross surgical specialty, two arm, parallel group, randomised controlled superiority trial. Adult patients with a SWHSI will be randomised to receive either NPWT or usual care (no NPWT) and will be followed up for 12 months. The primary outcome will be time to healing (defined as full epithelial cover in absence of a scab) in number of days since randomisation. Secondary outcomes will include key clinical events (hospital admission or discharge, treatment status, reoperation, amputation, antibiotic use and death), wound infection, wound pain, health-related quality of life, health utility and resource use.
   Discussion: Given the increasing use of NPWT, despite limited high-quality supporting evidence, the SWHSI-2 Trial will provide robust evidence on the clinical and cost-effectiveness of NPWT in the management of SWHSI. The SWHSI-2 Trial opened to recruitment in May 2019 and is currently recruiting across 20 participating centres.
C1 [Chetter, Ian; Arundel, Catherine; Martin, Belen Corbacho; Hewitt, Catherine; Fairhurst, Caroline; Joshi, Kalpita; Mott, Andrew; Rodgers, Sara; Goncalves, Pedro Saramago; Torgerson, David; Wilkinson, Jacqueline; Blazeby, Jane; Macefield, Rhiannon; Dixon, Stephen; Henderson, Eileen; Oswald, Angela; Dumville, Jo; Lee, Matthew; Pinkney, Thomas; Stubbs, Nikki; Wilson, Lyn] Univ York, Fac Sci, Dept Hlth Sci, York Trials Unit, Lower Ground Floor ARRC Bldg, York YO10 5DD, N Yorkshire, England.
C3 University of York - UK
RP Chetter, I (通讯作者)，Univ York, Fac Sci, Dept Hlth Sci, York Trials Unit, Lower Ground Floor ARRC Bldg, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI ; Blazeby, Jane/H-6703-2019; Dumville, Jo/O-7867-2014; Pinkney,
   Thomas/HGA-4022-2022; Mott, Andrew/HLQ-6922-2023; Torgerson,
   David/L-4566-2019
OI Wilkinson, Jacqueline/0000-0003-4543-2109; Blazeby,
   Jane/0000-0002-3354-3330; chetter, ian/0000-0002-2566-6859; Arundel,
   Catherine/0000-0003-0512-4339; Dumville, Jo/0000-0002-6546-3685;
   Macefield, Rhiannon/0000-0002-6606-5427; Pinkney,
   Thomas/0000-0001-7320-6673; Mott, Andrew/0000-0001-7844-9033; Hewitt,
   Catherine Elizabeth/0000-0002-0415-3536
FU National Institute for Health Research (NIHR) Health Technology
   Assessment Programme [17/42/94]; National Institutes of Health Research
   (NIHR) [17/42/94] Funding Source: National Institutes of Health Research
   (NIHR); Medical Research Council [MR/K025643/1] Funding Source:
   researchfish; MRC [MR/K025643/1] Funding Source: UKRI
FX This project was funded by the National Institute for Health Research
   (NIHR) Health Technology Assessment Programme (project reference
   17/42/94). The views expressed are those of the author(s) and not
   necessarily those of the NIHR or the Department of Health and Social
   Care. JB is an NIHR senior investigator.
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NR 29
TC 11
Z9 12
U1 1
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 25
PY 2021
VL 22
IS 1
AR 739
DI 10.1186/s13063-021-05662-2
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WM3EW
UT WOS:000710972800004
PM 34696784
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Pirela-Cruz, MA
   Machen, MS
   Esquivel, D
AF Pirela-Cruz, Miguel A.
   Machen, M. Shaun
   Esquivel, David
TI Management of large soft-tissue wounds with negative pressure therapy -
   Lessons learned from the war zone
SO JOURNAL OF HAND THERAPY
LA English
DT Article; Proceedings Paper
CT Conference on the Contributions of the Military Hand Therapist in Combat
   and Postdeployment Rehabilitation
CY 2005
CL San Antonio, TX
SP Brook Army Med Ctr
ID VACUUM-ASSISTED CLOSURE; INJURIES; EXPERIENCE; TRAUMA
AB The recent conflicts in Afghanistan and Iraq have demonstrated that body armor has led to increase survival of combatants but the extremity injuries have been alarming. The increased. numbers of extremity injuries have led to the acceptance and use of negative pressure therapy (NPT) in managing large wounds. This article reviews some of the lessons learned in treating wounds of the upper extremity using NPT.
C1 [Pirela-Cruz, Miguel A.] Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed & Rehabil, El Paso, TX 79905 USA.
   [Machen, M. Shaun] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
   [Esquivel, David] RE Thomason Hosp, El Paso, TX USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University; William Beaumont Army Medical
   Center
RP Pirela-Cruz, MA (通讯作者)，Texas Tech Univ, Hlth Sci Ctr, Dept Orthopaed & Rehabil, 4800 Alberta Ave, El Paso, TX 79905 USA.
EM Miguel.Pirelacruz@luke.uf.mil
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 18
TC 9
Z9 14
U1 0
U2 1
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
J9 J HAND THER
JI J. Hand Ther.
PD APR-JUN
PY 2008
VL 21
IS 2
BP 196
EP 202
DI 10.1197/j.jht.2007.12.007
PG 7
WC Orthopedics; Rehabilitation; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation; Surgery
GA 299PW
UT WOS:000255768500013
PM 18436141
DA 2026-07-24
ER

PT J
AU Taeger, CD
   Muehle, C
   Kruppa, P
   Prantl, L
   Biermann, N
AF Taeger, Christian D.
   Muehle, Clemens
   Kruppa, Philipp
   Prantl, Lukas
   Biermann, Niklas
TI Negative Pressure Wound Therapy-A Vacuum-Mediated Positive Pressure
   Wound Therapy and a Closer Look at the Role of the Laser Doppler
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy; positive pressure; laser doppler;
   perfusion; compression; NPWT
ID MICROVASCULAR BLOOD-FLOW; ASSISTED CLOSURE; PERFUSION; INCISION;
   MANAGEMENT; MECHANISMS; SURGERY
AB Background: Negative pressure wound therapy (NPWT) is an intensely investigated topic, but its mechanism of action accounts for one of the least understood ones in the area of wound healing. Apart from a misleading nomenclature, by far the most used diagnostic tool to investigate NPWT, the laser Doppler, also has its weaknesses regarding the detection of changes in blood flow and velocity. The aim of the present study is to explain laser Doppler readings within the context of NPWT influence. Methods: The cutaneous microcirculation beneath an NPWT system of 10 healthy volunteers was assessed using two different laser Dopplers (O2C/Rad-97 (R)). This was combined with an in vitro experiment simulating the compressing and displacing forces of NPWT on the arterial and venous system. Results: Using the O2C, a baseline value of 194 and 70 arbitrary units was measured for the flow and relative hemoglobin, respectively. There was an increase in flow to 230 arbitrary units (p = 0.09) when the NPWT device was switched on. No change was seen in the relative hemoglobin (p = 0.77). With the Rad-97 (R), a baseline of 92.91% and 0.17% was measured for the saturation and perfusion index, respectively. No significant change in saturation was noted during the NPWT treatment phase, but the perfusion index increased to 0.32% (p = 0.04). Applying NPWT compared to the arteriovenous-vessel model resulted in a 28 mm and 10 mm increase in the venous and arterial water column, respectively. Conclusions: We suspect the vacuum-mediated positive pressure of the NPWT results in a differential displacement of the venous and arterial blood column, with stronger displacement of the venous side. This ratio may explain the increased perfusion index of the laser Doppler. Our in vitro setup supports this finding as compressive forces on the bottom of two water columns within a manometer with different resistances results in unequal displacement.
C1 [Taeger, Christian D.; Muehle, Clemens; Prantl, Lukas; Biermann, Niklas] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
   [Kruppa, Philipp] Ernst Bergmann Klinikum, Dept Plast Hand & Reconstruct Surg, D-14467 Potsdam, Germany.
C3 University of Regensburg; Klinikum Ernst von Bergmann
RP Taeger, CD (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
EM taeger.christian@gmail.com; clemens-muehle@web.de; kruppaph@gmail.com;
   lukas.prantl@klinik.uni-regensburg.de;
   niklas.biermann@klinik.uni-regensburg.de
RI prantl, Lukas/AAM-1848-2021; Kruppa, Philipp/AAQ-1783-2020
OI prantl, Lukas/0000-0003-2454-2499; Kruppa, Philipp/0000-0003-1654-7257
FU Manfred Roth Stiftung
FX No Statement Available
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NR 29
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2024
VL 13
IS 8
AR 2351
DI 10.3390/jcm13082351
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OX5H8
UT WOS:001210585000001
PM 38673623
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Eggleston, RB
AF Eggleston, Randy B.
TI Wound Management Wounds with Special Challenges
SO VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
LA English
DT Article
DE Wound; Musculoskeletal; Genital
ID EXUBERANT GRANULATION-TISSUE; VACUUM-ASSISTED CLOSURE; THICKNESS SKIN
   WOUNDS; DISTAL LIMB; HYDROXYETHYL STARCH; TOPICAL APPLICATION; SILICONE
   GEL; PRESSURE; THERAPY; HORSE
AB Distal limb wounds in horses heal substantially different than trunk wounds, commonly resulting in exuberant granulation tissue and exposed and sequestered bone. Surgical intervention of severe rectovaginal lacerations in the mare should be delayed until the tissues have heeled and scar tissue has remodeled. Wounds resulting in severe hemorrhage require appropriate emergent fluid therapy and potentially transfusion therapy.
C1 [Eggleston, Randy B.] Univ Georgia, Coll Vet Med, Dept Large Anim Med, 2200 Coll Stn Rd, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP Eggleston, RB (通讯作者)，Univ Georgia, Coll Vet Med, Dept Large Anim Med, 2200 Coll Stn Rd, Athens, GA 30602 USA.
EM egglesto@uga.edu
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NR 85
TC 14
Z9 15
U1 2
U2 21
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0739
EI 1558-4224
J9 VET CLIN N AM-EQUINE
JI Vet. Clin. N. Am.-Equine Pract.
PD DEC
PY 2018
VL 34
IS 3
BP 511
EP +
DI 10.1016/j.cveq.2018.07.003
PG 29
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA HF6WL
UT WOS:000454378900006
PM 30447768
DA 2026-07-24
ER

PT J
AU He, ZH
   Yang, HM
AF He, Zhenhua
   Yang, Hongmei
TI Efficacy and safety of negative pressure wound therapy combined with
   alginate dressings for wound management: a meta-analysis
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE alginate; care; dressing; management; negative pressure wound therapy;
   nursing; wound
ID MULTICENTER; CARE
AB <bold>Background: </bold> Wound management remains a clinical challenge, with single-modality therapies such as negative pressure wound therapy (NPWT) or conventional dressings often failing to optimize healing efficiency and quality. This study aimed to systematically evaluate the clinical efficacy of NPWT combined with alginate dressings in wound treatment, providing evidence for clinical decision-making. <bold>Methods: </bold> A comprehensive search was conducted across Chinese and English databases from database inception to 30 November 2025. Randomized controlled trials (RCTs) comparing NPWT combined with alginate dressings (combined group) versus NPWT alone or routine dressing changes (control group) were included. Two researchers independently performed literature screening, data extraction, and risk of bias assessment using the Cochrane RoB 2.0 tool. Meta-analysis was conducted with RevMan 5.4 software. <bold>Results: </bold> A total of 11 RCTs involving 902 participants were included. Pooled results showed that the combined group significantly improved wound healing rate (OR = 2.64, 95% CI 1.60-4.36, I-2 = 30%) and Grade-A healing rate (OR = 4.69, 95% CI 2.56-8.57, I-2 = 0%), shortened healing time (days) (MD = -9.00, 95% CI -9.41 to -8.58, I-2 = 83%), reduced dressing change frequency (MD = -2.54, 95% CI -2.92 to -2.17, I-2 = 77%), and decreased wound pH value (MD = -0.82, 95% CI -1.08 to -0.57, I-2 = 61%) compared with the control group. Heterogeneity was moderate to high for partial outcomes, mainly attributed to variations in NPWT parameters (100-500 mmHg) and dressing protocols. No significant publication bias was detected (all p > 0.05). <bold>Conclusion: </bold> This meta-analysis finds that NPWT combined with alginate dressings significantly improves wound healing outcomes compared to monotherapy, with benefits observed primarily in hospital-based settings. While this combined regimen should be prioritized for complex or chronic wounds, judicious application of parameters-including careful monitoring at higher negative pressures-is warranted, and further health economic evaluation and standardized safety reporting are needed to optimize clinical decision-making.
C1 [He, Zhenhua] Shaoxing Inst Technol, Sch Med & Hlth, Shaoxing, Zhejiang, Peoples R China.
   [Yang, Hongmei] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Enshi, Hubei, Peoples R China.
C3 Shaoxing Institute of Technology
RP Yang, HM (通讯作者)，Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Enshi, Hubei, Peoples R China.
EM wam8f5@sina.com
FU Zhejiang Medical and Health Science and Technology Project [2025KY1706]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This study was funded by Zhejiang Medical and
   Health Science and Technology Project (Grant Number: 2025KY1706).
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NR 39
TC 0
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 1
PY 2026
VL 13
AR 1772888
DI 10.3389/fmed.2026.1772888
EA APR 2026
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GN0WC
UT WOS:001740310700001
PM 41994425
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, BR
   Fan, X
   Zhao, JC
   Shi, K
   Yu, JA
AF Zhang, Bo-Ru
   Fan, Xing
   Zhao, Jing-Chun
   Shi, Kai
   Yu, Jia-Ao
TI Negative pressure wound therapy with instillation and dwell time in the
   wound management of necrotizing fasciitis
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Necrotizing fasciitis; Negative pressure wound therapy; Wound bed
   preparation; Dwell time; Instillation therapy
ID RECOMMENDATIONS; DEBRIDEMENT; BIOBURDEN
AB Objective: Recent literature has shown that negative pressure wound therapy with instillation and dwell time (NPWTi-d) is a valid method of managing complex wounds and gained increasingly wider interest due in part to the increasing complexity of wounds. The purpose of this case study was to obtain information on the profile of NPWTi-d in necrotizing fasciitis patients, investigate the role it play in wound bed preparation, length of hospital stay and number of debridement operations.
   Methods: NPWTi-d has been used in patients with necrotizing fasciitis with either normal saline or Prontosan? solution and complete the treatment were involved in the present study. Following aggressive surgical debridement, NPWTi-d was initiated by instilling solution with a set dwell time of 5?10 min, followed by continuous NPWT of -125 mm Hg for 3?5 h. The system was changed on a 3?5 days schedule until sufficient granulation tissue was evident. Patients received systemic antibiotics and underwent wound debridement as indicated. Data of wound bed preparation, length of hospital stay, duration of NPWTi-d therapy, number of surgical interventions were collected retrospectively from patient medical records.
   Results: A total of 32 patients with diagnosis of necrotizing fasciitis received NPWTi-d were included. Granulation tissue was found to be sufficient in 9?16 days. The mean duration of NPWTi-d therapy was 12.5 days prior to wound closure by split-thickness autograft (n = 21), suture (n = 9), or flap transplantation (n = 2).Patients received NPWTi-d treatment over a period of 8?16 days. The mean length of hospitalization was 22.8 days. All wounds were successfully closed and no recurrence of infection or adverse event was observed during NPWTid treatment.
   Conclusion: In these patients, NPWTi-d facilitates wound cleansing and wound bed preparation and offers the clinician an additional tool for the management of necrotizing fasciitis. Further well designed prospective investigations with low risk of bias are needed to confirm these findings in the future work.
C1 [Zhang, Bo-Ru] First Hosp Jilin Univ, Cardiothorac Surg Care Platform, Changchun 130021, Peoples R China.
   [Fan, Xing; Zhao, Jing-Chun; Shi, Kai; Yu, Jia-Ao] First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
C3 Jilin University; Jilin University
RP Zhao, JC (通讯作者)，First Hosp Jilin Univ, Dept Burn Surg, 71 Xinmin St, Changchun 130021, Peoples R China.
EM jczhao@jlu.edu.cn
RI Zhang, Boru/AAN-8005-2020
FU Scientific and Technological Development Program of Jilin Province
   [20200201615JC]; Science and Technology Research Project of the
   Education Department of Jilin Province [JJKH20201074KJ]
FX This work received grants from the Scientific and Technological
   Development Program of Jilin Province (Grant No. 20200201615JC) ;
   Science and Technology Research Project of the Education Department of
   Jilin Province (Grant No. JJKH20201074KJ) .
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NR 35
TC 8
Z9 10
U1 0
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2021
VL 30
IS 2
BP 262
EP 266
DI 10.1016/j.jtv.2021.02.012
EA APR 2021
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA RU2PP
UT WOS:000644992700017
PM 33707160
DA 2026-07-24
ER

PT J
AU Fortelny, RH
   Hofmann, A
   Gruber-Blum, S
   Petter-Puchner, AH
   Glaser, KS
AF Fortelny, Rene H.
   Hofmann, Anna
   Gruber-Blum, Simone
   Petter-Puchner, Alexander H.
   Glaser, Karl S.
TI Delayed closure of open abdomen in septic patients is facilitated by
   combined negative pressure wound therapy and dynamic fascial suture
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Society-of-American-Gastrointestinal-and-Endoscopic-Surgeons (SAGES)
CY APR 17-20, 2013
CL Baltimore, MD
SP Soc Amer Gastrointestinal & Endoscop Surg
DE Secondary peritonitis; Open abdomen; Negative pressure wound therapy;
   Dynamic fascial suture; Delayed closure
ID ABDOMINAL-WALL DEFECTS; MANAGEMENT; MESH
AB The aim of this prospective controlled trial was the definition of the optimal timepoint for delayed closure after negative pressure wound therapy (NPWT) in the treatment of the open abdomen (OA) in septic patients after abdominal surgery. The delayed closure of the abdominal wall after abdominal NPWT treatment is often problematic due to the lateralization of the fascial edge leading to unfavorably high tensile forces of the adapting sutures in the midline. We present the results of an innovative combination of NPWT with a new fascial-approximation technique using dynamic fascial sutures (DFS) and delayed closure of the abdominal wall.
   Eighty-seven patients subjected to OA therapy following surgery for secondary peritonitis were treated with NPWT and DFS. In all patients, a running suture of elastic vessel loops was used to approximate fascial edges. This procedure was continued for the duration of NPWT until final closure of the abdomen with running suture in 55 patients (63.2 %) and interrupted suture technique in eight patients (9.2 %). An anterior component separation was performed in seven patients.
   Delayed closure was achieved in 68 patients (78.2 %) after 12.6 days [mean (SD) 25.1 (2-204)] days and 4.3 re-operations [mean (SD) 6.0 (1-43)]. Fifteen (17.2 %) superficial and two (2.3 %) deep wound infections occurred. In three (3.4 %) cases, entero-atmospheric fistulas had to be treated. We recorded no technique-specific complications. Four (5.9 %) incisional hernia were detected in a mean follow-up of 40.5 months (16-65). Mortality rate was 55.2 %.
   Using a new technique combining NPWT and DFS in the treatment of the OA, the delayed closure of the fascial edges by running suture can be achieved and the number of re-operations can be kept low. The technique was safe and led to a low incidence of incisional hernias. Extensive abdominal wall reconstruction was seldom required.
C1 [Fortelny, Rene H.; Hofmann, Anna; Gruber-Blum, Simone; Petter-Puchner, Alexander H.; Glaser, Karl S.] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, A-1171 Vienna, Austria.
   [Hofmann, Anna; Gruber-Blum, Simone; Petter-Puchner, Alexander H.] Ludwig Boltzmann Inst Expt & Clin Traumatol, A-1200 Vienna, Austria.
C3 Wilhelminenspital; Ludwig Boltzmann Institute; Ludwig Boltzmann
   Institute for Experimental & Clinical Traumatology
RP Fortelny, RH (通讯作者)，Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1171 Vienna, Austria.
EM rene.fortelny@wienkav.at
RI /S-5290-2019; Fortelny, René/AAD-5922-2021
CR Albertsmeier M, 2012, LANGENBECK ARCH SURG, V397, P363, DOI 10.1007/s00423-011-0884-6
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   Brandl A, 2013, HERNIA
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   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
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NR 26
TC 51
Z9 56
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2014
VL 28
IS 3
BP 735
EP 740
DI 10.1007/s00464-013-3251-6
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AB7HX
UT WOS:000331961500004
PM 24149855
DA 2026-07-24
ER

PT J
AU Kawakita, T
   Iqbal, SN
   Overcash, RT
AF Kawakita, Tetsuya
   Iqbal, Sara N.
   Overcash, Rachael T.
TI Negative pressure wound therapy system in extremely obese women after
   cesarean delivery compared with standard dressing
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Cesarean; extreme obesity; negative pressure wound therapy; surgical
   site infection; wound complication
ID SURGICAL SITE INFECTION; RISK-FACTORS; COMPLICATIONS
AB Objective: Data regarding the use of the negative pressure wound therapy (NPWT) system in extremely obese women (body mass index [BMI] >= 50 kg/m(2)) undergoing cesarean delivery are limited. We sought to examine the rate of wound complications in extremely obese women according to postcesarean dressings (NPWT [PICO, Smith & Nephew, St. Peterburg, FL] versus standard dressings). Study design: This was a retrospective cohort study of all extremely obese women (BMI >= 50 kg/m(2)) at 23 weeks' gestation or greater who underwent cesarean delivery at an academic teaching hospital in Washington, DC, between January 2009 and September 2017. During this period, a PICO Single Use NPWT system was used at our institution. Women who missed a postpartum follow-up were excluded. Since 2014, Medstar Washington Hospital Center recommended the use of a PICO Single Use NPWT system for extremely obese women at the time of delivery. However, the ultimate decision to use the NPWT was made by attending physicians, considering the cost of the device and the risk of wound complication. Our primary outcome was a composite of cellulitis, hematoma/seroma, and wound dehiscence. Coarsened exact matching with k-to-k solution was performed using BMI, rupture of membranes, and labor. Results: Of 179 extremely obese women, 73 (40.8%) and 106 (59.2%) received NPWT and standard dressings, respectively; 61 women who received NPWT were matched to 61 women who received standard dressings. The rates of the primary outcome in the unmatched cohort were similar between women who received NPWT and those who received standard dressings (20.6 versus 16.0%; p = .44). The rates of primary outcome remained similar between women who received NPWT and those who received standard dressings after matching (18.0 versus 18.0%; p = 1.00). Conclusion: In extremely obese women undergoing cesarean delivery, prophylactic PICO NPWT was not associated with a decreased risk of the primary outcome compared with standard dressings. A large prospective randomized controlled trial would be useful to answer if NPWT is beneficial for extremely obese women.
C1 [Kawakita, Tetsuya; Iqbal, Sara N.; Overcash, Rachael T.] Medstar Washington Hosp Ctr, Div Maternal Fetal Med, Obstet & Gynecol, 101 Irving St NW,5 B45, Washington, DC 20010 USA.
C3 MedStar Washington Hospital Center
RP Kawakita, T (通讯作者)，Medstar Washington Hosp Ctr, Div Maternal Fetal Med, Obstet & Gynecol, 101 Irving St NW,5 B45, Washington, DC 20010 USA.
EM tetsuya.x.kawakita@gmail.com
RI Kawakita, Tetsuya/H-7559-2019
CR Blackwell M, 2009, STATA J, V9, P524, DOI 10.1177/1536867X0900900402
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NR 18
TC 6
Z9 8
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD FEB 16
PY 2021
VL 34
IS 4
BP 634
EP 638
DI 10.1080/14767058.2019.1611774
EA MAY 2019
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA PH5RK
UT WOS:000473542800001
PM 31018727
DA 2026-07-24
ER

PT J
AU Malmsjö, M
   Gustafsson, L
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Gustafsson, Lotta
   Lindstedt, Sandra
   Ingemansson, Richard
TI Negative Pressure Wound Therapy-associated Tissue Trauma and Pain: A
   Controlled In vivo Study Comparing Foam and Gauze Dressing
   Removal by Immunohistochemistry for Substance P and Calcitonin
   Gene-related Peptide in the Wound Edge
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE animal model; controlled study; negative pressure wound therapy; pain;
   dressing
ID CLOSURE; LIDOCAINE; IMPACT
AB Pain upon negative pressure wound therapy (NPWT) dressing removal has been reported and is believed to be associated with the observation that granulation tissue grows into foam. Wound tissue damage upon removal of the foam may cause the reported pain. Calcitonin gene-related peptide (CGRP) and substance P are neuropeptides that cause inflammation and signal pain and are known to be released when tissue trauma occurs. The aim of this controlled in vivo study was to compare the expression of CGRP and substance P in the wound bed in control wounds and following NPWT and foam or gauze dressing removal. Eight pigs with two wounds each were treated with open-pore structure polyurethane foam or AMD gauze and NPWT of 0 (control) or -80 mm Hg for 72 hours. Following removal of the wound filler, the expression of CGRP and substance P was measured, using arbitrary units, in sections of biopsies from the wound bed using immunofluorescence techniques. Substance P and CGRP were more abundant in the wound edge following the removal of foam than of gauze dressings and least abundant in control wounds. The immunofluorescence staining of the wound edge for CGRP was 52 +/- 3 au after the removal of gauze and 97 +/- 5 au after the removal of foam (P < 0.001). For substance P, the staining was 55 +/- 3 au after gauze removal and 95 +/- 4 au after foam removal (P < 0.001). CGRP and substance P staining was primarily located to nerves and leukocytes. The increase in CGRP and substance P immunofluorescence was especially prominent in the dermis but also was seen in subcutaneous and muscle tissue. Using gauze may be one way of reducing NPWT dressing change-related pain. New wound fillers designed to optimize granulation tissue formation and minimize pain issues presumably will be developed in the near future.
C1 [Malmsjo, Malin; Gustafsson, Lotta] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, Malin; Lindstedt, Sandra; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Gustafsson, Lotta/0000-0002-9826-9133
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeanssom Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation; Prospera (Forth Worth, TX)
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeanssom Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, Lars Hierta's Memorial Foundation, and
   Prospera (Forth Worth, TX).
CR Benemei S, 2009, CURR OPIN PHARMACOL, V9, P9, DOI 10.1016/j.coph.2008.12.007
   Blakely M, 2007, S ADV WOUND CAR TAMP
   Bollero D, 2007, WOUND REPAIR REGEN, V15, P589, DOI 10.1111/j.1524-475X.2007.00267.x
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   Morykwas M, 2003, 1 INT TOP NEG PRESS, P39
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   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 21
TC 12
Z9 17
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD DEC
PY 2011
VL 57
IS 12
BP 30
EP 35
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 871XR
UT WOS:000298771500007
PM 22156176
DA 2026-07-24
ER

PT J
AU Hayashi, D
   Kojima, K
   Tokunaga, T
   Okishio, K
   Yoon, H
AF Hayashi, Daiki
   Kojima, Kensuke
   Tokunaga, Toshiteru
   Okishio, Kyoichi
   Yoon, Hyungeun
TI Single-stage open window thoracostomy with simultaneous muscle flap
   transposition and early negative pressure wound therapy for chronic
   empyema: a propensity score- and machine learning-based study
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Bronchopleural fistula; Chronic empyema; Muscle flap transposition;
   Negative pressure wound therapy; Open window thoracostomy
ID MANAGEMENT
AB Background To compare the clinical efficacy of a single-stage surgical approach combining open window thoracostomy, muscle flap transposition, and early negative pressure wound therapy (NPWT) with that of conventional staged management for chronic empyema. Methods This retrospective, single-center cohort included 45 patients with chronic empyema (single-stage, n = 7; conventional, n = 38) who were treated from 2009 to 2024. The primary endpoint was the cavity reduction ratio measured via three-dimensional computed tomography (3D CT). To minimize selection bias, we applied propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). We prespecified the average treatment effect on the treated (ATT) as the primary estimand, whereas the average treatment effect (ATE) was considered exploratory because treatment assignment was strongly related to bronchopleural fistula (all single-stage patients had BPF) and overlap was limited. The follow-up intervals were linearly normalized to adjust for time-dependent variability. Machine learning models were used as complementary predictive analyses to identify predictors of cavity reduction. Results After PSM (n = 5 per group), the single-stage group had significantly greater cavity reduction than the conventional group did (90% [89-94%] vs. 37% [32-43%], p = 0.008). The IPTW analysis demonstrated significant treatment effects: 0.38 (95% CI: 0.17-0.59, p = 0.005) for the ATT and 0.63 (95% CI: 0.12-1.14, p = 0.03) for the ATE (exploratory). Machine learning models consistently identified the treatment approach and time-related variables as important predictors of cavity reduction. Conclusions Compared with conventional management, the single-stage approach was associated with significantly greater empyema cavity reduction and was feasible even in patients with bronchopleural fistulas. Causal interpretation is most defensible for the ATT, whereas generalization to the full population (ATE) should be considered exploratory due to limited overlap. Despite the small sample size, the consistent findings across diverse analytical frameworks support the single-stage strategy as a promising approach that warrants prospective multicenter validation and clearer criteria for patient selection.
C1 [Hayashi, Daiki; Kojima, Kensuke; Tokunaga, Toshiteru; Yoon, Hyungeun] NHO Kinki Chuo Chest Med Ctr, Dept Gen Thorac Surg, 1180 Nagasone Cho,Kita Ku, Sakai, Osaka 5918555, Japan.
   [Okishio, Kyoichi] Clin Res Ctr, NHO Kinki Chuo Chest Med Ctr, Osaka, Japan.
   [Okishio, Kyoichi] NHO Kinki Chuo Chest Med Ctr, Dept Thorac Oncol, Osaka, Japan.
RP Kojima, K (通讯作者)，NHO Kinki Chuo Chest Med Ctr, Dept Gen Thorac Surg, 1180 Nagasone Cho,Kita Ku, Sakai, Osaka 5918555, Japan.
EM k7kensuke@icloud.com
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD APR 3
PY 2026
VL 21
IS 1
AR 235
DI 10.1186/s13019-026-03997-y
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA IA1FC
UT WOS:001766798800010
PM 41933357
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tank, JC
   Georgiadis, GM
   Bair, JM
   Rice, A
   O'Mara Gardner, K
   Chen, JT
   Redfern, RE
AF Tank, Jason C.
   Georgiadis, Gregory M.
   Bair, Jeffrey M.
   Rice, Alexi
   O'Mara Gardner, Kristin
   Chen, John T.
   Redfern, Roberta E.
TI Does The Use of Ethyl Chloride Improve Patient-Reported Pain Scores With
   Negative Pressure Wound Therapy Dressing Changes? A Prospective,
   Randomized Controlled Trial
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Ethyl chloride; negative pressure wound therapy; pain; dressing change;
   vapocoolant
ID VAPOCOOLANT SPRAY; LIDOCAINE; REDUCE; CREAM
AB Background Negative pressure wound therapy (NPWT) is commonly used for surgical incisions and large wounds, particularly in the context of trauma. Research has shown that patients report that the most painful aspect of NPWT is related to foam dressing changes. This study aimed to determine whether topical use of the vapocoolant anesthetic ethyl chloride would impact patient-reported pain during these procedures. Methods This study was a single-blinded, placebo-controlled randomized trial in patients who were undergoing NPWT foam dressing change following surgery performed by the orthopedic trauma team. A total of 100 patients were randomized to receive ethyl chloride topical anesthetic spray or placebo (tissue culture grade water) during dressing change. The outcome measure specified prior to enrollment was a mean decrease in patient-reported pain of 1.7 points using a numeric rating scale. Baseline and procedural characteristics were collected to investigate contributions to patient-reported pain. We hypothesized that the use of ethyl chloride would decrease patient reported pain scores. Results Significantly more females were randomized to the receive vapocoolant; remaining baseline and procedural characteristics were similar between groups. The median time for NPWT drape removal was 2.0 minutes in both groups (p = 0.66). The postprocedural pain reported by patients was significantly lower in the experimental group compared with placebo (median, 5.0 vs. 7.0; p = 0.03). Multivariate analysis adjusting for potential confounders showed treatment group to be the strongest predictor of postprocedure pain (p = 0.002). Additionally, a generalized linear model suggests that treatment group was the strongest predictor of change in pain score as reported by patients prior to and immediately following dressing change. Conclusions Use of vapocoolant spray during NPWT dressing change for orthopedic trauma wounds and surgical incisions was feasible and resulted in significant reduction in patient-reported pain associated with the procedure. LEVEL OF EVIDENCE Therapeutic, Level I
C1 [Tank, Jason C.; Georgiadis, Gregory M.; Bair, Jeffrey M.] ProMed Toledo Hosp, Dept Orthopaed Surg, Sect Orthopaed Trauma, Toledo, OH USA.
   [Rice, Alexi] ProMed Toledo Hosp, Enterostomal Therapy, Toledo, OH USA.
   [O'Mara Gardner, Kristin] ProMed Toledo Hosp, Dept Orthopaed, Toledo, OH USA.
   [Chen, John T.] Bowling Green State Univ, Dept Math & Stat, Bowling Green, OH 43403 USA.
   [Redfern, Roberta E.] ProMed Toledo Hosp, ProMed Res, Toledo, OH USA.
C3 University System of Ohio; Bowling Green State University
RP Tank, JC (通讯作者)，ProMed Toledo Hosp, 2121 Hughes Dr,310, Toledo, OH 43606 USA.
EM Jason.tankmd@promedica.org; gregory.georgiadismd@promedica.org;
   jeffrey.bairmd@promedica.org; alexi.rice@promedica.org;
   kristin.gardner@promedica.org; jchen@bgsu.edu;
   roberta.redfern@promedica.org
RI georgiadis, gregory/AAO-8347-2020
OI georgiadis, gregory/0000-0001-6477-5700; Redfern,
   Roberta/0000-0001-9883-2910
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
   Ali SR, 2018, ANN ROY COLL SURG, V100, P347, DOI 10.1308/rcsann.2018.0010
   [Anonymous], 2008, INT WOUND J S4, V5, piii, DOI DOI 10.1111/J.1742-1481X.2008.00537.X
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NR 29
TC 1
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JUN
PY 2021
VL 90
IS 6
BP 1061
EP 1066
DI 10.1097/TA.0000000000003157
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA TC0GW
UT WOS:000668324000034
PM 33755640
DA 2026-07-24
ER

PT J
AU Foley, MP
   Fahey, C
   Byrne, AM
   Lowery, A
   Walsh, SR
AF Foley, Megan Power
   Fahey, Ciara
   Byrne, Anne-Marie
   Lowery, Aoife
   Walsh, Stewart R.
TI Systematic Review and Meta-analysis of Prophylactic Negative Pressure
   Wound Therapy Devices for Major Lower Extremity Amputations
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Major lower extremity amputation; Negative pressure wound therapy;
   Surgical complications; Surgical site infection
ID SURGICAL SITE INFECTION; LOWER-LIMB AMPUTATION; RISK-FACTORS;
   COMPLICATIONS; PREVENTION; MORTALITY; TRENDS; IMPACT; COSTS
AB Objective: Major lower extremity amputations are commonly performed for limb threatening ischaemia and uncontrollable infection. The dysvascular and diabetic cohort have multiple risk factors for post-operative wound complications. Prophylactic incisional negative pressure wound therapy (NPWT) has been associated with significantly lower rates of surgical site infection (SSI). The aim of this updated systematic review was to examine the impact of NPWT on outcomes after major amputations. Data Sources: PubMed, Scopus, Embase, conference abstracts, and trial registries were searched. Review Methods: Studies of all methodologies comparing NPWT applied to closed incisions with dry dressings after major amputations were eligible. The meta-analyses compared the relative risk (RR) of overall wound complications and SSIs between NPWT and standard care. Risk of bias was assessed using the Methodological Index for Non-Randomised Studies (MINORS) criteria and Cochrane Risk of Bias 2 tool. Outcome certainty was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria. Results: Nine studies were identified, including three randomised controlled trials (RCTs) and six cohort studies. Overall study quality was moderate to poor, with very low outcome certainty on GRADE analyses. Seven hundred and forty-nine patients were included, with 336 receiving NPWT and 413 standard care. The pooled rate of wound complications was 16.0% (95% confidence interval [CI] 9.5-24.0%) for NPWT and 44.6% (95% CI 29.0-60.9%) for standard care. Prophylactic NPWT was associated with a statistically significantly lower composite complication rate (RR 0.42, 95% CI 0.29-0.60; p<.001; I-2= 0%) and SSI rate (RR 0.51, 95% CI 0.31-0.83; p=.007; I-2= 0%) compared with standard care. Conclusion: Although the quality of the included studies was variable, prophylactic NPWT may reduce wound complications after major amputation. Further adequately powered RCTs are needed to clarify the benefits and cost effectiveness of NPWT in this cohort, including whether it should be used routinely or selectively.
C1 [Foley, Megan Power; Lowery, Aoife; Walsh, Stewart R.] Univ Galway, Dept Surg, Galway, Ireland.
   [Foley, Megan Power; Walsh, Stewart R.] Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
   [Fahey, Ciara; Byrne, Anne-Marie; Walsh, Stewart R.] Royal Coll Surgeons Ireland, Natl Surg Res Support Ctr, Dublin, Ireland.
   [Lowery, Aoife] Hlth Res Board Clin Res Facil, Galway, Ireland.
   [Walsh, Stewart R.] Univ Galway, Lambe Inst Translat Res, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Royal College of Surgeons in
   Ireland - RCSI; Ollscoil na Gaillimhe-University of Galway
RP Foley, MP (通讯作者)，Univ Hosp Galway, Dept Vasc Surg, Newcastle Rd, Galway H91 YR71, Ireland.
EM meganpfoley@rcsi.com
RI Walsh, Stewart/AFZ-2791-2022; Power Foley, Megan/JXX-0685-2024
OI Walsh, Stewart/0000-0002-1006-9541; Fahey, Ciara/0009-0006-6620-0111;
   LOWERY, AOIFE/0000-0002-8062-6235; 
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NR 49
TC 4
Z9 4
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2025
VL 70
IS 3
BP 346
EP 356
DI 10.1016/j.ejvs.2025.04.026
EA SEP 2025
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 7LS3F
UT WOS:001574007000001
PM 40228785
DA 2026-07-24
ER

PT J
AU Ciliberti, M
   De Lara, F
   Serra, G
   Tafuro, F
   Iazzetta, FM
   Filosa, A
   Scognamiglio, R
   Ciliberti, G
   Veneri, MR
AF Ciliberti, Marino
   De lara, Francesco
   Serra, Gianfranco
   Tafuro, Felice
   Iazzetta, Francesco Maria
   Filosa, Alessia
   Scognamiglio, Rosa
   Ciliberti, Giorgia
   Veneri, Maria Rosaria
TI The Effect of a Bacteria- and Fungi-binding Mesh Dressing on the
   Bacterial Load of Pressure Ulcers Treated With Negative Pressure Wound
   Therapy: A Pilot Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE pressure ulcers; negative pressure wound therapy; bacterial load;
   critical colonization; wound infection; bacteria- and fungi-binding mesh
   dressing
ID INFECTION
AB Objective. This study was designed to clinically evaluate the efficacy of a bacteria- and-fungi-binding mesh (BFBM) dressing to modify the bacterial load of pressure ulcers (PUs) of categories 3 Land 4, when used as a wound contact layer (WCL) during negative pressure wound therapy (NPWT). Methods. This was an observational single-centre study in patients with PUs of categories 3 or 4, who were treated with NPWT. Patients were observed for 7 days and received NPWT at -80 mm Hg with the BFBM dressing as the WCL. Wound biopsies were performed at Inclusion (130), at 48 hours (B1), and at day 7 (B7). Bacteria- and fungi-binding mesh dressings were examined for bacterial load at 48 hours (D1) and at 7 days (D7). The primary endpoint was the changes in bacterial loads. Results, Fifty patients were enrolled; 43 (86%) of their PUs were on the sacrum. At B0, 3 groups of wounds were identified by the bioburden level: group A had negative results (28%) to bacterial loads from 10(2) to 5 x 10(3) colony forming units (CFO) CFU/mL (18%); group B had 10(4) to 10(5) CFU/mL (18%); and group C with >= 106 CFU/ML (36%). The authors did not find any significant difference in bacterial loads in group A, but significant differences were found in group B at B1 and B7 (P = 0.04 and P = 0.0067) and in group C at B1 and B7 (P < 0.00001). There was no significant difference on the bacterial loads of the dressing at D1 and D7 (P=0.823). No device-related adverse events were reported. Conclusion. The BFBM dressing seems to be at the origin of a statistically significant reduction of bacterial burden in wounds with moderate or high levels of colonization. The authors' findings suggest BFBM dressings may be a WCL of choice during the treatment of chronic wounds with NPWT.
C1 [Ciliberti, Marino; De lara, Francesco; Serra, Gianfranco; Tafuro, Felice; Iazzetta, Francesco Maria] ASL NAPOLI 3 SUD, Ctr Aziendale Riparaz Tissutale, Naples, Italy.
   [Filosa, Alessia; Scognamiglio, Rosa; Ciliberti, Giorgia; Veneri, Maria Rosaria] ASL NAPOLI 3 SUD, San Leonardo Hosp, Micobiol Unit, Naples, Italy.
RP Ciliberti, M (通讯作者)，ASL NAPOLI 3 SUD, Tissue Repair Ctr, Ctr Aziendale Riparaz Tissutale, Via Fusco 12, I-80058 Naples, Italy.
EM marinodoct@gmail.com
CR [Anonymous], 2009, TREATM PRESS ULC QUI
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NR 29
TC 11
Z9 11
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 408
EP 420
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800007
PM 27589361
DA 2026-07-24
ER

PT J
AU Nacea, DI
   Enescu, DM
   Pertea, M
   Mitrache, P
   Gavrila, IM
   Tatar, R
AF Nacea, Doina Iulia
   Enescu, Dan Mircea
   Pertea, Mihaela
   Mitrache, Petruta
   Gavrila, Iulia Mihaela
   Tatar, Raluca
TI Integrating Negative-Pressure Wound Therapy in the Therapeutic Protocol
   of Extensive Pediatric Burns: Current Practice and Further Treatment
   Decision Algorithm
SO MEDICINA-LITHUANIA
LA English
DT Article
DE pediatric burns; extensive burns; negative-pressure wound therapy; burn
   local treatment; electrical burns
ID MANAGEMENT; EXPERIENCE; EFFICACY
AB Background and Objectives: Extensive burns are devastating injuries, especially in children, associating high risk of morbidity and mortality in the absence of immediate and appropriate treatment. Negative-pressure wound therapy (NPWT) has emerged as a versatile tool for the local treatment of burn wounds. This study aims to present our approach in using NPWT for extensive burns in children, emphasizing the indications and outcomes of these very challenging cases, and proposing an algorithm for NPWT use for extensive burn patients, even in low-resource settings. Materials and Methods: We retrospectively analyzed pediatric burn patients admitted between January 2020 and December 2024, selecting the cases with at least 20% TBSA burn and the application of NPWT during treatment, recording indications and parameters of use, treatment period, and results. Results: We identified 12 patients with a burn surface ranging from 20% to 80% TBSA, caused by high-voltage electrical current (6 cases), flame (4 cases), and scalds (2 cases). NWPT was used for 3-25% TBSA for obtaining granulation tissue in very deep burn wounds with bone and tendon exposure, for reducing edema and enhancing spontaneous re-epithelialization in intermediate circumferential burns, and for preparing the wound bed for re-grafting after local infection and graft failure. There were no complications related with the NPWT use and no fatalities. Conclusions: NPWT represents a reliable option for several clinical situations in local burn treatment, for temporary closure of burn areas, graft fixation, burn wound preparation, local infection control, or enhancing re-epithelialization. The proposed algorithm offers a comprehensive overview of indications of NPWT for burn local management and may guide clinical decisions, easing the identification of the best situation and moment to use the device. Our study contributes to the body of knowledge that enforces the evidence of the safe and effective use of NPWT for burn management in the pediatric population.
C1 [Nacea, Doina Iulia; Enescu, Dan Mircea; Mitrache, Petruta; Tatar, Raluca] Carol Davila Univ Med & Pharm, Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.
   [Nacea, Doina Iulia; Enescu, Dan Mircea; Mitrache, Petruta; Tatar, Raluca] Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, Bucharest 010621, Romania.
   [Pertea, Mihaela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Plast Surg & Reconstruct, Iasi 700115, Romania.
   [Pertea, Mihaela] Sf Spiridon Emergency Cty Hosp, Dept Plast Surg & Reconstruct Microsurg, Iasi 700111, Romania.
   [Gavrila, Iulia Mihaela] Carol Davila Univ Med & Pharm, St John Clin Emergency Hosp, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.
   [Gavrila, Iulia Mihaela] St John Clin Emergency Hosp, Dept Plast Reconstruct Surg, Bucharest 042122, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Mitrache, P (通讯作者)，Carol Davila Univ Med & Pharm, Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg, Bucharest 020021, Romania.; Mitrache, P (通讯作者)，Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, Bucharest 010621, Romania.; Pertea, M (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Plast Surg & Reconstruct, Iasi 700115, Romania.; Pertea, M (通讯作者)，Sf Spiridon Emergency Cty Hosp, Dept Plast Surg & Reconstruct Microsurg, Iasi 700111, Romania.
EM iulia.nacea@umfcd.ro; mihaela.pertea@umfiasi.ro;
   petruta.mitrache@drd.umfcd.ro; raluca.tatar@umfcd.ro
RI Nacea, Doina Iulia/OLR-9981-2025; Tatar, Raluca/AAF-4712-2021
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   World Health Organization Burns, US
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NR 54
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 30
PY 2026
VL 62
IS 5
AR 852
DI 10.3390/medicina62050852
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IM2AX
UT WOS:001774992400001
PM 42195105
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Latouche, V
   Devillers, H
AF Latouche, Valerie
   Devillers, Herve
TI Benefits of negative pressure wound therapy with instillation in the
   treatment of hard-to-heal wounds: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wounds; diabetes; dissecting haematoma; injuries; negative
   pressure wound therapy with instillation; postoperative wounds; pressure
   ulcers; trauma wounds; wounds
ID COMPLEX WOUNDS; SALINE; OUTCOMES
AB Objective: Impaired wound healing can lead to hard-to-heal wounds, which impact on patients, clinicians and healthcare systems. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) was developed to manage wounds through early-stage cleansing. This study describes the use of NPWTi-d to help manage hard-to-heal wounds in patients with risk factors for impaired wound healing.
   Method: In this case series, patients were treated between October 2015 and March 2018 at a community hospital in western France. Normal saline solution was instilled into wounds with a dwell time of 10 minutes, followed by the application of negative pressure at -75 mmHg to -125 mmHg for 2-3 hours. If needed, patients were given appropriate oral or intravenous antibiotic treatment in conjunction with NPWTi-d and subsequent wound therapies.
   Results: A total of 15 patients participated in the study. Mean age was 81 +/- 13 years, and 12 (80%) patients were malnourished with blood albumin levels of 30.1 +/- 5.7g/l, and 12 (80%) patients were given antibiotic therapy. The mean duration of NPWTi-d was 19.4 +/- 20.8 days, with a mean number of dressing changes of 6.6 +/- 6.8; the duration of NPWTi-d and the number of dressing changes for pressure ulcers was three times that of the other wound types. The mean cost of NPWTi-d in this study was (sic)1643.40 +/-(sic)1709.13. Overall, NPWTi-d provided early-stage wound cleansing and helped achieve adequate granulation tissue formation and progression to the next phase of wound healing.
   Conclusion: In these cases, NPWTi-d was a beneficial and effective method of treating hard-to-heal wounds that were resistant to traditional treatments, yielding favourable clinical outcomes. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Latouche, Valerie; Devillers, Herve] Hosp Ctr Intercommunal Redon Carentoir, Dept Geriatr & Phys Therapy & Rehabil, Redon, France.
RP Latouche, V (通讯作者)，Hosp Ctr Intercommunal Redon Carentoir, Dept Geriatr & Phys Therapy & Rehabil, Redon, France.
EM infirmiere.plaiecica@ch-redon.fr
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NR 24
TC 5
Z9 5
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2020
VL 29
IS 4
BP 248
EP 253
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LA5YT
UT WOS:000524023900013
PM 32281508
DA 2026-07-24
ER

PT J
AU Wee, IJY
   Syn, N
   Choong, AMTL
AF Wee, Ian J. Y.
   Syn, Nicholas
   Choong, Andrew M. T. L.
TI Closed Incision Negative Pressure Wound Therapy in Vascular Surgery: A
   Systematic Review and Meta-Analysis
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Closed incision negative pressure wound therapy; Vascular surgery;
   Surgical site infections
ID SURGICAL SITE INFECTION; ARTERIAL RECONSTRUCTION; COMPLICATIONS;
   PREVENTION; PATIENT
AB Background: Closed incision negative pressure wound therapy (CiNPT) may be a valuable treatment option for surgical site infections. This systematic review and meta-analysis sought to compare CiNPT against conventional wound care after vascular procedures.
   Methods: This study conformed to the PRISMA guidelines. An electronic search was performed on Medline/Pubmed, EMBASE, and the Cochrane Library. The date of last search was July 11 2018. Relative risks and mean differences for primary and secondary outcomes were calculated. A random effects model was used for substantial heterogeneity (I-2 > 30%). The Cochrane Risk of Bias tool was employed to rate the methodological quality of the included studies, whilst the GRADE approach was use to grade the level of evidence for the observed effects.
   Results: Of 47 studies, five randomised controlled trials (RCTs) were included, comprising 662 patients, of which 47.9% underwent CiNPT and 52.1% received conventional care. The overall risk of infection (RR = 0.31, 95% CI 0.21-0.47) (high quality), Szilagyi Grades I (RR = 0.35, 95% CI 0.20-0.60) (high quality), and III (RR = 0.17, 95% CI 0.04-0.68) (high quality) infections, need for antibiotics (RR = 0.36, 95% CI 0.20-.64) (high quality), and surgical re-intervention (RR = 0.27, 95% CI 0.27-0.98) (high quality) were lower in the CiNPT group. However, there were no significant differences in the risk of Grade II (RR = 0.59, 95% CI 0.10-3.66) (moderate quality), as well as length of hospital stay (mean difference, MD = -0.59, 95% CI -2.48 to 1.31) (moderate quality), and 30 day mortality (RR = 3.95, 95% CI 0.17-94.76) (high quality).
   Conclusion: While there is evidence demonstrating that CiNPT reduces the risk of Grades I and III infections and re-interventions, there was a noticeable lack of difference in other important post-operative outcomes. Further well designed RCTs are needed to corroborate these findings.
C1 [Wee, Ian J. Y.; Syn, Nicholas; Choong, Andrew M. T. L.] SingVaSC, Singapore Vasc Surg Collaborat, Singapore, Singapore.
   [Wee, Ian J. Y.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore.
   [Choong, Andrew M. T. L.] Natl Univ Heart Ctr, Div Vasc Surg, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore
RP Choong, AMTL (通讯作者)，Natl Univ Heart Ctr, Dept Cardiac Thorac & Vasc Surg, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
EM suramctl@nus.edu.sg
RI Syn, Nicholas/A-3770-2017; Choong, Andrew/B-7168-2013
OI Syn, Nicholas/0000-0002-6343-176X; Choong, Andrew/0000-0002-7171-4516
CR [Anonymous], 2009, BMJ-BRIT MED J, V21, P7, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.7326/0003-4819-151-4-200908180-00135]
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   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
NR 24
TC 21
Z9 22
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2019
VL 58
IS 3
BP 446
EP 454
DI 10.1016/j.ejvs.2018.12.021
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA IV1AT
UT WOS:000484010400031
PM 31378658
OA Bronze
DA 2026-07-24
ER

PT J
AU Hurd, T
   Trueman, P
   Rossington, A
AF Hurd, Theresa
   Trueman, Paul
   Rossington, Alan
TI Use of a Portable, Single-use Negative Pressure Wound Therapy Device in
   Home Care Patients with Low to Moderately Exuding Wounds: A Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case reports; negative-pressure wound therapy; wounds; community health
   care
ID ASSISTED CLOSURE VAC; COST-EFFECTIVENESS; MULTICENTER; TRIAL
AB Negative pressure wound therapy (NPWT) is widely used in the management of acute and chronic wounds. The purpose of this 8-week study was to evaluate outcomes of using a new canisterless, portable, single-use NPWT system in patients with wounds treated in a Canadian community healthcare setting. The device is designed to provide negative pressure at 80 +/- 20 mm Hg, 24 hours a day of continuous usage, for a maximum wear time of 7 days. Data on wound outcomes, including exudate levels, wound appearance, and wound area, were collected weekly by a Registered Nurse as part of routine practice. When treatment was discontinued, patients and nurses were asked to rate their satisfaction with the device. Data from patients who had used a conventional NPWT device to manage their wounds were retrospectively abstracted from their medical records. In the prospective study, conducted between October 2011 and July 2012,326 patients (median age = 61 years; range 17-91 years) with wounds of mixed etiology (53 pressure ulcers, 21 venous leg ulcers, 16 diabetic foot ulcers, and 15 traumatic and 221 surgical wounds) were treated for a maximum of 8 weeks with the portable NPWT device. The majority of patients (228 out of 326; 68%) achieved complete wound closure within 8 weeks of treatment. The Kaplan-Meier estimate of median time to healing of all wounds was 9 weeks. The majority of patients (318 patients, 97%) reported they were pleased or satisfied with the dressing performance. Nurses indicated satisfaction with the dressing performance for all but two patients (99%). The majority (89%) of patients managed with conventional, NPWT (n = 539) had an open surgical wound with moderate or high levels of exudate. Healing rates in the portable and conventional NPWT group were similar (10% to 11% per week). Portable, single-use NPWT has the potential to deliver good wound outcomes in community care settings and simplify the use of negative pressure for nurses and patients. Additional research is needed to evaluate treatment efficacy and cost effectiveness.
C1 [Hurd, Theresa] Nursing Practice Solut, Toronto, ON, Canada.
   [Rossington, Alan] Smith & Nephew, Stat & Data Programme, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Smith & Nephew
RP Trueman, P (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM paul.trueman@smith-nephew.com
OI Roldán Díaz, Irene/0009-0008-3975-8085
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   Borgquist O, 2011, OSTOMY WOUND MANAG, V57, P44
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   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
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   *SMITH NEPH, NEG PRESS WOUND THER
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   Trueman P, 2008, INT WOUND J, V5, P23, DOI 10.1111/j.1742-481X.2008.00468.x
   Upton D, 2013, J WOUND CARE, V22, P34, DOI 10.12968/jowc.2013.22.1.34
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 18
TC 33
Z9 33
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2014
VL 60
IS 3
BP 30
EP 36
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD9FU
UT WOS:000333571000004
PM 24610558
DA 2026-07-24
ER

PT J
AU Frykberg, RG
   Speight, JH
AF Frykberg, R. G.
   Speight, John H.
TI Advanced Wound Therapies
SO CLINICS IN PODIATRIC MEDICINE AND SURGERY
LA English
DT Article
DE Limb salvage; Wound therapy; Silver; Hyperbaric oxygen; Topical oxygen;
   Negative pressure; Skin substitute
ID VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN THERAPY; DIABETIC FOOT ULCER;
   AMPUTATION; SILVER; MANAGEMENT; MULTICENTER
AB The past decades have seen an incredible variety of innovations in the field of wound care, including both the development of new technologies and the refinement of longstanding treatment modalities. While research is ongoing as to the efficacy of many of these therapies, practitioners have a number of tools they should consider as they treat patients.
C1 [Frykberg, R. G.] Univ Texas Hlth Sci Ctr, Dept Orthopaed, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
   [Speight, John H.] Beth Israel Deaconess Med Ctr, Dept Surg, 185 Pilgrim Rd, Boston, MA 02215 USA.
C3 University of Texas System; University of Texas at San Antonio; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center
RP Speight, JH (通讯作者)，Beth Israel Deaconess Med Ctr, Dept Surg, 185 Pilgrim Rd, Boston, MA 02215 USA.
EM jspeight@bidmc.harvard.edu
FU McCord Research
FX R.G. Frykberg is a consultant to Advanced Oxygen Therapy, Inc. and
   McCord Research.
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NR 54
TC 0
Z9 0
U1 3
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0891-8422
EI 1558-2302
J9 CLIN PODIATR MED SUR
JI Clin. Podiatr. Med. Surg.
PD OCT
PY 2025
VL 42
IS 4
BP 635
EP 645
DI 10.1016/j.cpm.2025.06.003
EA OCT 2025
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 8YL7O
UT WOS:001600332600006
PM 41101881
DA 2026-07-24
ER

PT J
AU Achten, J
   Vadher, K
   Bruce, J
   Nanchahal, J
   Spoors, L
   Masters, JP
   Dutton, S
   Madan, J
   Costa, ML
AF Achten, Juul
   Vadher, Karan
   Bruce, Julie
   Nanchahal, Jagdeep
   Spoors, Louise
   Masters, James P.
   Dutton, Susan
   Madan, Jason
   Costa, Matthew L.
TI Standard wound management versus negative-pressure wound therapy in the
   treatment of adult patients having surgical incisions for major trauma
   to the lower limb - a two-arm parallel group superiority randomised
   controlled trial: protocol for Wound Healing in Surgery for Trauma
   (WHIST)
SO BMJ OPEN
LA English
DT Article
ID TIBIAL PLAFOND; HEALTH; FRACTURES; EUROQOL; PAIN
AB Introduction Patients with dosed high-energy injuries associated with major trauma have surprisingly high rates of surgical site infection in incisions created during fracture fixation. One factor that may reduce the risk of surgical site infection is the type of dressing applied over the dosed surgical incision. In this multicentre randomised clinical trial, negative-pressure wound therapy will be compared with standard dressings with outcomes of deep infection, quality of life, pain and disability.
   Methods and analysis Adult patients presenting to hospital within 72 hours of sustaining major trauma, requiring a surgical incision to treat a fractured lower limb, are eligible for inclusion. Randomisation, stratified by trial centre, open/closed fracture at presentation and Injury Severity Score (ISS) <= 15 versus ISS >= 16 will be administered via a secure web-based service using minimisation. The random allocation will be to either standard wound management or negative-pressure wound therapy. Trial participants will usually have clinical followup at the local fracture clinic for a minimum of 6 months, as per standard National Health Service practice. Diagnosis of deep infection will be recorded at 30 days. Functional, pain and quality of life outcome data will be collected using the Disability Rating Index, Douleur Neuropathique Questionnaire and Eurogol - 5 Dimension - 5 level (EQ-5D-5L) questionnaires at 3 months and 6 months postinjury. Further data will be captured on resource use and any late postoperative complications. Longer term outcomes will be assessed annually for 5 years and reported separately.
   Ethics and dissemination National Research Ethics Committee approved this study on 16 February 2016 16/WM/0006. The National Institute for Health Research Health Technology Assessment monograph and a manuscript to a peer-reviewed journal will be submitted on completion of this trial. The results of this trial will inform clinical practice on the clinical and cost-effectiveness of the treatment of this injury.
C1 [Achten, Juul; Spoors, Louise; Masters, James P.; Costa, Matthew L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
   [Vadher, Karan; Dutton, Susan] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Clin Trials Res Unit, Ctr Stat Med, Oxford, England.
   [Bruce, Julie; Madan, Jason] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Coventry, W Midlands, England.
   [Nanchahal, Jagdeep] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
C3 University of Oxford; University of Oxford; University of Warwick;
   University of Oxford; Kennedy Institute for Rheumatology
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford, England.
EM matthew.costa@ndorms.ox.ac.uk
RI Achten, Juul/KUD-8515-2024; Bruce, Julie/G-7588-2014; Masters,
   James/U-8764-2019
OI Achten, Juul/0000-0002-8857-5743; Dutton, Susan/0000-0003-4573-5257;
   Bruce, Julie/0000-0002-8462-7999; Costa, Matthew/0000-0003-3644-1388;
   Masters, James/0000-0001-9663-8858; Nanchahal,
   Jagdeep/0000-0002-9579-9411
FU UK National Institute for Health Research Health Technology Assessment
   (HTA) Programme [14/199/14]; National Institute for Health Research
   (NIHR) Oxford Biomedical Research Centre; National Institute for Health
   Research [14/199/14] Funding Source: researchfish; The Dunhill Medical
   Trust [DMT/RCS605] Funding Source: researchfish
FX This project was funded by the UK National Institute for Health Research
   Health Technology Assessment (HTA) Programme (project number 14/199/14)
   and was supported by the National Institute for Health Research (NIHR)
   Oxford Biomedical Research Centre.
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NR 28
TC 9
Z9 9
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2018
VL 8
IS 6
AR e022115
DI 10.1136/bmjopen-2018-022115
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GJ7LG
UT WOS:000435567900103
PM 29880575
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Park, CH
   Shon, OJ
   Kim, GB
AF Park, Chul Hyun
   Shon, Oog Jin
   Kim, Gi Beom
TI Negative pressure wound therapy for Gustilo Anderson grade IIIb open
   tibial fractures
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Gustilo Anderson grade IIIb open fractures; negative pressure wound
   therapy; staged protocol; tibia
ID SUBATMOSPHERIC PRESSURE; STAGED PROTOCOL; MANAGEMENT; FIXATION; SHAFT;
   FLAP; RECONSTRUCTION; TRAUMA
AB Background: Traditionally, Gustilo Anderson grade IIIb open tibial fractures have been treated by initial wide wound debridement, stabilization of fracture with external fixation, and delayed wound closure. The purpose of this study is to evaluate the clinical and radiological results of staged treatment using negative pressure wound therapy (NPWT) for Gustilo Anderson grade IIIb open tibial fractures.
   Materials and Methods: 15 patients with Gustilo Anderson grade IIIb open tibial fractures, treated using staged protocol by a single surgeon between January 2007 and December 2011 were reviewed in this retrospective study. The clinical results were assessed using a Puno scoring system for severe open fractures of the tibia at the last followup. The range of motion (ROM) of the knee and ankle joints and postoperative complication were evaluated at the last followup. The radiographic results were assessed using time to bone union, coronal and sagittal angulations and a shortening at the last followup.
   Results: The mean score of Puno scoring system was 87.4 (range 67-94). The mean ROM of the knee and ankle joints was 121.3 degrees (range 90 degrees-130 degrees) and 37.7 degrees (range 15 degrees-50 degrees), respectively. Bone union developed in all patients and the mean time to union was 25.3 weeks (range 16-42 weeks). The mean coronal angulation was 2.1 degrees (range 0-4 degrees) and sagittal was 2.7 degrees (range 1-4 degrees). The mean shortening was 4.1 mm (range 0-8 mm). Three patients had partial flap necrosis and 1 patient had total flap necrosis. There was no superficial and deep wound infection.
   Conclusion: Staged treatment using NPWT decreased the risks of infection and requirement of flap surgeries in Gustilo Anderson grade IIIb open tibial fractures. Therefore, staged treatment using NPWT could be a useful treatment option for Gustilo Anderson grade IIIb open tibial fractures.
C1 [Park, Chul Hyun; Shon, Oog Jin; Kim, Gi Beom] Yeungnam Univ Hosp, Dept Orthoped Surg, Daemyung Dong 317-1, Daegu 705717, South Korea.
C3 Yeungnam University; Yeungnam University Hospital
RP Shon, OJ (通讯作者)，Yeungnam Univ Hosp, Dept Orthoped Surg, Daemyung Dong 317-1, Daegu 705717, South Korea.
EM ossoj@med.yu.ac.kr
RI Kim, Gi Beom/AAG-6315-2020; Park, Chul Hyun/ABE-4464-2020
OI Kim, Gi Beom/0000-0002-4067-1285; Park, Chul Hyun/0000-0002-3101-8655
FU Yeungnam University Medical Center
FX This research was supported by a grant of Yeungnam University Medical
   Center (2014).
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NR 26
TC 10
Z9 15
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD SEP-OCT
PY 2016
VL 50
IS 5
BP 536
EP 542
DI 10.4103/0019-5413.189604
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DW9NM
UT WOS:000383987100014
PM 27746498
OA hybrid
DA 2026-07-24
ER

PT J
AU Sun, HJ
   Yang, CX
   Liu, XK
   Liang, J
   Geng, HF
AF Sun, Haojie
   Yang, Chengxin
   Liu, Xuekui
   Liang, Jun
   Geng, Houfa
TI Effectiveness of Negative Pressure Wound Therapy of Diabetic Foot Ulcers
   Using Periplaneta Americana (Kangfuxin Liquid) Irrigation
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcers; Kangfuxin liquid; negative-pressure wound therapy
   with instillation; wound healing
ID ANTISEPTIC SOLUTION; NORMAL SALINE; OUTCOMES
AB This study was to evaluate the efficacy of Periplaneta Americana (Kangfuxin Liquid) relative to normal saline when applied in negative-pressure wound therapy (NPWT) with instillation for facilitating diabetic foot ulcers (DFUs) healing. Eighty patients with Wagner grades 3 or 4 DFUs were enrolled in this retrospective study. Based on the treatment type, patients were equally assigned to either (i) an NPWT with Kangfuxin liquid instillation group (NPWT-K) or (ii) an NPWT with normal saline instillation group (NPWT-I). The primary study outcome was the wound healing rate and Kaplan-Meier survival estimate was used to examine the cumulative wound healing rate, while the secondary outcomes were the amputation rate, inpatient days, duration of antibiotic treatments, reinfection rate, new ulcer formation rate, readmission rate, and changes in the inflammatory markers (such as ESR, CRP, and PCT) and serum growth factors (including VEGF, EGF, and bFGF). The 12-week wound healing rate (31 of 40[77.5%] vs 22 of 40[55.0%], P = .033) and the cumulative wound healing rate was higher in the NPWT-K group than in the NPWT-I group (P = .004). The wound healing time was shorter in the NPWT-K group (55 days [95% CI 50-60]) than in the NPWT-K group (64 days [95% CI 59-69], P = .016). Patients who received NPWT-K had fewer inpatient days and duration of antibiotic treatment and faced lower reinfection and readmission rates (P < .05). After 1 week of treatment, the ESR, CRP, and PCT levels in the blood were lower in the NPWT-K group than in the NPWT-I group (P < .05), while the VEGF, EGF, and bFGF levels in the NPWT-K group were higher than those in the NPWT-I group (P < .001). The present study showed that NPWT with Kangfuxin liquid instillation was effective and showed significantly accelerated DFUs healing. Thus, Kangfuxin liquid is an effective instillation solution for use in the treatment of DFUs with NPWT.
C1 [Sun, Haojie; Liu, Xuekui; Liang, Jun] Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou, Jiangsu, Peoples R China.
   [Yang, Chengxin; Geng, Houfa] Xuzhou Med Univ, Xuzhou, Jiangsu, Peoples R China.
   [Geng, Houfa] Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.
   [Liang, Jun] Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou 221009, Jiangsu, Peoples R China.
C3 Southeast University - China; Xuzhou Medical University; Xuzhou Medical
   University; Xuzhou Medical University; Southeast University - China;
   Xuzhou Medical University
RP Geng, HF (通讯作者)，Xuzhou Med Univ, Xuzhou 221000, Jiangsu, Peoples R China.; Liang, J (通讯作者)，Southeast Univ, Xuzhou Med Univ, Xuzhou Cent Hosp, Affiliated XuZhou Hosp,Med Coll,Xuzhou Clin Sch, Xuzhou 221009, Jiangsu, Peoples R China.
EM mwlj521@njmu.edu.cn; genghoufa@njmu.edu.cn
RI Houfa, Geng/ABI-6352-2020; Sun, Haojie/LRT-6797-2024
FU Xuzhou Primary Research & Development projects [KC21274]; Pengcheng
   Talents-Medical Youth Reserve Talents [XWRCHT20220004]
FX The author(s) disclosed receipt of the following financial supportfor
   the research, authorship, and/or publication of this article:This work
   was supported by Xuzhou Primary Research & Development projects,
   KC21274; Pengcheng Talents-Medical Youth Reserve Talents,
   XWRCHT20220004.
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NR 35
TC 1
Z9 5
U1 4
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2025
VL 24
IS 4
BP 1165
EP 1172
DI 10.1177/15347346231176917
EA MAY 2023
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9IU0P
UT WOS:001001167000001
PM 37203153
DA 2026-07-24
ER

PT J
AU Li, J
   Wang, HY
   Yang, YF
   Wang, AN
   Shi, Y
   Cui, TB
AF Li, Jin
   Wang, Hong-Yu
   Yang, Yu-Feng
   Wang, An-Na
   Shi, Yan
   Cui, Ting-Bao
TI 被撤回的出版物: Efficacy of the combination of Chinese herbal medicine and
   negative pressure wound therapy in the treatment of patients with
   diabetic foot ulcer: A meta-analysis (Retracted article. See vol. 22,
   2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE Chinese herbal medicine compound; diabetic foot ulcer; meta-analysis;
   negative pressure wound therapy
AB This study aimed to systematically evaluate the clinical efficacy of Chinese herbal medicine combined with negative pressure wound therapy (NPWT) in the treatment of diabetic foot ulcers (DFU). Computerised searches of the China National Knowledge Infrastructure, Wanfang, Chinese BioMedical Literature Database, PubMed, Cochrane Library and Embase databases were conducted for randomised controlled trials on the use of Chinese herbal medicines combined with NPWT for the treatment of DFU. The search period ranged from the time of establishment of each database to July 2023. Literature screening and data extraction were performed independently by two investigators, and the quality of the included studies was assessed. The meta-analysis was performed using Review Manager 5.4 software. A total of 25 studies were analysed, including 1777 DFUs, with 890 and 887 patients in the experimental and control groups, respectively. The results showed that the treatment of DFUs with a Chinese herbal medicine in combination with NPWT increased the overall effectiveness (odds ratio [OR] = 4.32, 95% confidence interval [CI]: 2.96-6.30, p < 0.001), wound healing rate (mean difference [MD] = 18.35, 95% CI: 13.07-23.64, p < 0.001) and ankle brachial index (MD = 0.10, 95% CI: 0.06-0.14, p < 0.001); reduced the wound healing time (MD = -11.01, 95% CI: -13.25 to -8.78, p < 0.001) and post-treatment wound area (MD = -1.73, 95% CI: -2.46 to -1.01, p < 0.001); decreased the C-reactive protein level (MD = -3.57, 95% CI: -5.13 to -2.00, p < 0.001); and increased vascular endothelial growth factor level (MD = 19.20, 95% CI: 8.36-30.05, p < 0.001). Thus, Chinese herbal medicines combined with NPWT can effectively promote wound healing, reduce inflammation and shorten the disease course in patients with DFU, while demonstrating precise clinical efficacy.
C1 [Li, Jin; Cui, Ting-Bao] Liaoning Univ Tradit Chinese Med, Dept Dev Res Ctr, Shenyang, Liaoning, Peoples R China.
   [Wang, Hong-Yu; Yang, Yu-Feng; Wang, An-Na; Shi, Yan] Liaoning Univ Tradit Chinese Med, Dept Sch Nursing, Shenyang, Liaoning, Peoples R China.
   [Shi, Yan] Liaoning Univ Tradit Chinese Med, Shenyang 110847, Liaoning, Peoples R China.
   [Cui, Ting-Bao] Liaoning Univ Tradit Chinese Med, Dept Dev Res Ctr, Shenyang 110847, Liaoning, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Liaoning University
   of Traditional Chinese Medicine; Liaoning University of Traditional
   Chinese Medicine; Liaoning University of Traditional Chinese Medicine
RP Shi, Y (通讯作者)，Liaoning Univ Tradit Chinese Med, Shenyang 110847, Liaoning, Peoples R China.; Cui, TB (通讯作者)，Liaoning Univ Tradit Chinese Med, Dept Dev Res Ctr, Shenyang 110847, Liaoning, Peoples R China.
EM 196375446@qq.com; lijin110901@163.com
RI Wang, Hongyu/KIK-3613-2024
FU Research on International Talent Cultivation Mode in the Context of
   Chinese Medicine Professional Accreditation-Taking Acupuncture and
   Moxibustion as an Example
FX No Statement Available
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NR 40
TC 3
Z9 4
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2024
VL 21
IS 4
DI 10.1111/iwj.14536
EA DEC 2023
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LW2G9
UT WOS:001117924900001
PM 38069543
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhu, J
   Wang, FF
   Yan, L
   Wang, JW
   Wu, MZ
   Hu, R
   An, Y
AF Zhu, Jin
   Wang, Fangfang
   Yan, Li
   Wang, Junwen
   Wu, Mingzheng
   Hu, Rui
   An, Ying
TI Negative pressure wound therapy enhances bone regeneration compared with
   conventional therapy in a rabbit radius gap-healing model
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE negative pressure wound therapy; bone regeneration; mesenchymal stem
   cells; vascular endothelial growth factor; bone morphogenetic protein 2;
   osteopontin
AB Negative pressure wound therapy (NPWT) has been recognized as an effective method for the treatment of intractable wounds. However, its effects on bone healing remain to be elucidated. Our previous study demonstrated that NPWT induced cell proliferation and osteoblastic differentiation of rat periosteum-derived mesenchymal stem cells (P-MSCs). It was reported that following NPWT treatment, the expression of the mechanotransduction molecule integrin beta 5 is increased, indicating that NPWT may serve an active role in fracture healing by enhancing bone formation and reducing bone resorption. The present study sought to further investigate the efficacy of NPWT on the bone regeneration process in a rabbit radial gap-healing model. All rabbits with radial defects were randomly divided into two groups: NPWT and control groups. Continuous negative pressure at -125 mmHg was applied to all rabbits. Furthermore, X-ray imaging and scoring on day 7, 14, 21 and 28 postoperatively were performed to evaluate new bone formation. Histological changes were determined via hematoxylin and eosin and Masson's trichrome staining at 2- and 4-weeks following surgery. In addition, vimentin-positive cells located in the periosteum were detected via immunohistochemical examination on day 3 post operation. Finally, protein expression levels of vascular endothelial growth factor (VEGF), bone morphogenetic protein (BMP)-2 and osteopontin (OPN) were evaluated using western blot analysis on the 2nd and 4th week following NPWT. X-ray and histological examination revealed that the bone-healing processes in the NPWT group were faster compared with the control group. Additionally, compared with the control group, the NPWT group exhibited higher X-ray scores, increased percentage of positive vimentin-stained cells and upregulated expression of VEGF, BMP-2 and OPN proteins. The aforementioned findings suggest that NPWT, under a continuous negative pressure of -125 mmHg, may accelerate bone regeneration by enhancing MSC proliferation, osteoblastic differentiation and VEGF, BMP-2 and OPN expression.
C1 [Zhu, Jin; Yan, Li; Wang, Junwen; Wu, Mingzheng; Hu, Rui; An, Ying] Huazhong Univ Sci & Technol, Wuhan Hosp 4, Puai Hosp, Tongji Med Coll,Dept Orthoped, 473 Hanzheng St, Wuhan 430000, Hubei, Peoples R China.
   [Wang, Fangfang] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430000, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Yan, L (通讯作者)，Huazhong Univ Sci & Technol, Wuhan Hosp 4, Puai Hosp, Tongji Med Coll,Dept Orthoped, 473 Hanzheng St, Wuhan 430000, Hubei, Peoples R China.
EM swyanli666@hotmail.com
RI ; Wang, Fangfang/KII-9109-2024
OI Wu, Mingzheng/0000-0001-8282-4510; 
FU Natural Science Fund of Hubei Provincial Health Commission [2020CFB464];
   Wuhan Municipal Health Commission [WX20Q15]
FX The present study was supported by the Natural Science Fund of Hubei
   Provincial Health Commission (grant no. 2020CFB464) and Wuhan Municipal
   Health Commission (grant no. WX20Q15).
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NR 38
TC 9
Z9 11
U1 1
U2 13
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2021
VL 21
IS 5
AR 474
DI 10.3892/etm.2021.9905
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RA5ZS
UT WOS:000631497600001
PM 33767769
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Davis, KE
   La Fontaine, J
   Farrar, D
   Oz, OK
   Crisologo, PA
   Berriman, S
   Lavery, LA
AF Davis, Kathryn E.
   La Fontaine, Javier
   Farrar, David
   Oz, Orhan K.
   Crisologo, Peter A.
   Berriman, Sandra
   Lavery, Lawrence A.
TI Randomized clinical study to compare negative pressure wound therapy
   with simultaneous saline irrigation and traditional negative pressure
   wound therapy for complex foot infections
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
AB The aim of this study was to compare the efficacy of different negative pressure wound therapy (NPWT) devices and NPWT with and without simultaneous irrigation in patients admitted to hospital with moderate and severe foot infections. Ninety patients were randomized in a 12-week prospective, randomized noninferiority trial to compare wound healing in patients with moderate and severe infected foot wounds treated with NPWT after surgery. Inclusion criteria included ABI > 0.5 or toe pressures >30 PVR/mmHg, >18 years of age and exclusion included active Charcot arthropathy, collagen vascular disease, HIV, and hypercoagulable state. We compared two different traditional devices, NPWT-K (KCI, VAC Ulta) and NPWT-C (Cardinal, PRO), and NPWT-I with saline irrigation (Cardinal, PRO). All patients had therapy delivered at 125 mmHg continuous pressure. In patients who received simultaneous saline irrigation (NPWT-I), the administration rate was 15 ml per hour. The primary outcome was the proportion of healed wounds in 12 weeks. Secondary outcomes included surgical wound closure, number of surgeries, length of stay, and time to wound healing. Continuous data was presented as mean +/- standard deviation. Analysis of variance was used to compare continuous variables and chi-square to compare dichotomous variables with an alpha of 0.05. There were no differences in outcomes among NPWT-I, NPWT-C, and NPWT-K groups in proportion of healed wounds (63.3%, 50.0%, 46.7% p = 0.39), surgical wound closure (83.3%, 80.0%, 63.3%, p = 0.15), number of surgeries (2.0 +/- 0.49, 2.4 +/- 0.77, 2.4 +/- 0.68, p = 0.06), length of stay (16.3 +/- 15.7, 14.7 +/- 7.4, 15.3 +/- 10.5 days, p = 0.87), time to wound healing (46.2 +/- 22.8, 40.9 +/- 18.8, 45.9 +/- 28.3 days, p = 0.78). We did not identify any significant differences in clinical outcomes or adverse events between patients treated with different NPWT devices or NPWT with and without irrigation.
C1 [Davis, Kathryn E.; La Fontaine, Javier; Crisologo, Peter A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
   [Farrar, David] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol & Mol Biol, Dallas, TX 75390 USA.
   [Oz, Orhan K.] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX USA.
   [Berriman, Sandra] Berriman Consulting, Princeton, NJ USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; University of Texas System; University of Texas
   Southwestern Medical Center
RP Lavery, LA (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM larry.lavery@utsouthwestern.edu
RI Crisologo, Peter/JZE-5379-2024; Oz, Orhan/GVT-7264-2022
OI Crisologo, Peter/0000-0002-5367-9235; Lavery,
   Lawrence/0000-0002-7920-9952; 
FU Cardinal Health, Inc., Dublin, OH, USA
FX This was an investigator-initiated study funded by Cardinal Health,
   Inc., Dublin, OH, USA.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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NR 20
TC 31
Z9 36
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2020
VL 28
IS 1
BP 97
EP 104
DI 10.1111/wrr.12741
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA QI3OM
UT WOS:000618888700011
PM 31245901
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Wang, WH
   Lou, YF
   Yang, LF
   Zhou, P
AF Wang, Wenhua
   Lou, Yang Feng
   Yang, Long Fei
   Zhou, Peng
TI Salvage of preputial flap necrosis in penile glans melanosis using
   Integra dermal regeneration template and split-thickness skin graft: A
   case report
SO MEDICINE
LA English
DT Article
DE dermal regeneration template; flap necrosis; Integra; negative-pressure
   wound therapy; penile glans melanosis; preputial flap; psychosexual
   outcome; split-thickness skin graft
AB Rationale: Penile glans melanosis is a benign but psychologically distressing condition. While surgical excision with flap reconstruction is a standard treatment for extensive lesions, total flap necrosis presents a significant reconstructive challenge. This report describes a successful salvage strategy using a dermal regeneration template (Integra) and split-thickness skin grafting (STSG) after the failure of a primary preputial flap. Patient concerns: A 24-year-old male with a 2.0 & times; 1.5 cm benign melanosis of the glans penis underwent complete excision and reconstruction with a pedicled inner preputial flap. However, at the 3-week follow-up, the patient presented with complete flap necrosis, necessitating further intervention. Diagnoses: Postoperative complete necrosis of the pedicled inner preputial flap following excision of glans melanosis. Interventions: Following thorough debridement of the necrotic tissue, a staged salvage procedure was initiated. First, a single-layer Integra Dermal Regeneration Template was applied to the wound bed and managed with continuous negative-pressure wound therapy at -125 mm Hg for 3 weeks to promote neodermis formation. Subsequently, a 0.3-mm meshed STSG harvested from the right thigh was transplanted onto the matured neodermis and secured with negative-pressure wound therapy for 5 days. Outcomes: Complete epithelialization was achieved 6 months postoperatively, resulting in a smooth contour and minimal scarring. At the 24-month follow-up, the patient reported preserved erogenous sensation (2-point discrimination of 5 mm) and improved psychosexual satisfaction, with IIEF-15 scores increasing from 5/10 to 8/10. No recurrence or contracture was observed. Lessons: Staged reconstruction using a dermal regeneration template followed by STSG is a reliable and effective salvage technique for flap failure in glans surgery. This approach avoids the complications of secondary flap harvesting while ensuring excellent functional, sensory, and cosmetic outcomes, making it a valuable tool for complex penile surface reconstruction.
C1 [Lou, Yang Feng] Hangzhou Third Peoples Hosp, Dept Gen Surg, Hangzhou, Peoples R China.
   [Yang, Long Fei; Zhou, Peng] Hangzhou Third Peoples Hosp, Dept Urol, Hangzhou 310009, Zhejiang, Peoples R China.
RP Zhou, P (通讯作者)，Hangzhou Third Peoples Hosp, Dept Urol, Hangzhou 310009, Zhejiang, Peoples R China.
EM 1295744809@qq.com; cwgebao@126.com; 250810584@qq.com;
   13616555138@139.com
CR Alnajjar HM, 2020, CURR OPIN UROL, V30, P213, DOI 10.1097/MOU.0000000000000711
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NR 11
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 15
PY 2026
VL 105
IS 20
AR e48843
DI 10.1097/MD.0000000000048843
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IA8XH
UT WOS:001767323200032
PM 42152403
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jia, ZG
   Liu, L
   Zhang, SQ
   Zhao, XT
   Luo, L
   Tang, YZ
   Shen, B
   Chen, MW
AF Jia, Zeguo
   Liu, Lei
   Zhang, Shiqian
   Zhao, Xiaotong
   Luo, Li
   Tang, Yizhong
   Shen, Bing
   Chen, Mingwei
TI Proteomics changes after negative pressure wound therapy in diabetic
   foot ulcers
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE diabetic foot ulcer; negative-pressure wound therapy; label-free
   quantitative mass spectrometry; differentially expressed proteins;
   cathepsin S; protein S isoform 1; inter alpha-trypsin inhibitor heavy
   chain H4; peroxiredoxin-2
ID CATHEPSIN-S; PROTEIN-S; TRYPSIN INHIBITOR; SKIN; FIBRONECTIN;
   EXPRESSION; TISSUE; ULCERATION; MIGRATION; SURVIVAL
AB Label-free quantitative mass spectrometry was used to analyze the differences in the granulation tissue protein expression profiles of patients with diabetic foot ulcers (DFUs) before and after negative-pressure wound therapy (NPWT) to understand how NPWT promotes the healing of diabetic foot wounds. A total of three patients with DFUs hospitalized for Wagner grade 3 were enrolled. The patients received NPWT for one week. The granulation tissue samples of the patients prior to and following NPWT for one week were collected. The protein expression profiles were analyzed with label-free quantitative mass spectrometry and the differentially expressed proteins (DEPs) in the DFU patients prior to and following NPWT for one week were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted to annotate the DEPs and DEP-associated signaling pathways. Western blotting and ELISA were performed to validate the results. By comparing the differences in the protein profiles of granulation tissue samples prior to and following NPWT for one week, 36 proteins with significant differences were identified (P<0.05); 33 of these proteins were upregulated and three proteins were downregulated. NPWT altered proteins mainly associated with antioxidation and detoxification, the cytoskeleton, regulation of the inflammatory response, complement and coagulation cascades and lipid metabolism. The functional validation of the DEPs demonstrated that the levels of cathepsin S in peripheral blood and granulation tissue were significantly lower than those prior to NPWT (P<0.05), while the levels of protein S isoform 1, inter alpha-trypsin inhibitor heavy chain H4 and peroxiredoxin-2 in peripheral blood and granulation tissue were significantly higher than those prior to NPWT (P<0.05). The present study identified multiple novel proteins altered by NPWT and laid a foundation for further studies investigating the mechanism of action of NPWT.
C1 [Jia, Zeguo; Liu, Lei; Zhang, Shiqian; Zhao, Xiaotong; Luo, Li; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, Hefei 230032, Anhui, Peoples R China.
   [Shen, Bing] Anhui Med Univ, Sch Basic Med Sci, Hefei 230022, Anhui, Peoples R China.
   [Chen, Mingwei] Anhui Univ Chinese Med, Inst Tradit Chinese Med Prevent & Control Diabet, Hefei 230012, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui University of Chinese Medicine
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM chmwl@163.com
RI CHEN, MINGWEI/KHT-6744-2024
OI , Bing/0000-0001-7263-4748
FU Key Research and Development Program of Anhui Province
   [202004a07020016]; Natural Science Foundation of Anhui Province
   [2108085MH269]
FX This study was supported by grants from the Key Research and Development
   Program of Anhui Province (grant no. 202004a07020016) and the Natural
   Science Foundation of Anhui Province (grant no. 2108085MH269).
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NR 74
TC 12
Z9 17
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2021
VL 24
IS 6
AR 834
DI 10.3892/mmr.2021.12474
PG 15
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA WF3UL
UT WOS:000706233500001
PM 34608502
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Enescu, DM
   Stoicescu, S
   Tomita, M
   Nacea, I
   Ionita, D
   Tatar, R
AF Enescu, Dan Mircea
   Stoicescu, Simona
   Tomita, Maria
   Nacea, Iulia
   Ionita, Dan
   Tatar, Raluca
TI Management of lower extremity traumatic injuries with negative pressure
   wound therapy: Experience of a pediatric plastic surgery department
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative Pressure Wound Therapy; Pediatric trauma; Lower extremity; Skin
   and soft tissue defects
ID CHILDREN; INFANTS; FLAP; SKIN
AB Introduction: Extensive lower limb traumatic injuries are particularly challenging when they associate skin and soft tissue defects, moreover when the patient is a child. In view of more frequent recommendations and reports of negative pressure wound therapy (NPWT) use for severe trauma and extensive soft tissue defects of the lower extremity, we aimed at reviewing the indications and outcomes of this technique in our pediatric plastic surgery department.
   Method: We performed a retrospective study for the period 2016-2019, in order to identify patients having suffered injuries of the ankle and foot, for who NPWT was used in the therapeutic protocol.
   Results: For the study period we identified a total of 9 children with ankle and foot injuries who had NPWT in their therapeutic protocol. The average age was 10 years (range 3 years 5 months to 14 years 4 months) and 8 of them were pedestrians, victims of traffic accidents. Five patients presented with associated injuries and fractures in other anatomic locations. NPWT was started 1-3 days after admission and it was used in average for 21.77 days, with good results in all cases. For 8 patients NPWT was sufficient to contract the wound and cover exposed bone and tendons before closing with split thickness skin graft (STSG). One patient needed also a free muscular flap transfer before grafting. All patients achieved complete healing and started physical therapy before discharging.
   Conclusion: NPWT has proven to be an easy to use, safe and effective therapeutic tool for pediatric patients, with considerable improvement for healing in case of traumatic injuries of foot and ankle, presenting extensive skin and soft tissue defects and bone exposure in children. NPWT is also suitable for children since its use implies less frequent dressing changes, and decreases the level of pain and anxiety, and spares donor areas needed for more complicated procedures and, by creating an optimal grafting bed, it ensures good outcomes, in the short term and long term as well. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Enescu, Dan Mircea; Stoicescu, Simona; Tatar, Raluca] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Enescu, Dan Mircea; Stoicescu, Simona; Tomita, Maria; Nacea, Iulia; Ionita, Dan; Tatar, Raluca] Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, 30-32 Iancu Hunedoara Blvd,1st Dist, Bucharest 011743, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Stoicescu, S (通讯作者)，Grigore Alexandrescu Clin Emergency Hosp Children, Dept Plast Reconstruct Surg & Burns, 30-32 Iancu Hunedoara Blvd,1st Dist, Bucharest 011743, Romania.
EM simona_ioana@hotmail.com
RI NACEA, DOINA IULIA/OLR-9981-2025; Tatar, Raluca/AAF-4712-2021
OI NACEA, DOINA IULIA/0009-0008-9760-5896; Tatar,
   Raluca/0000-0002-4606-4064
FU European Federation of Societies of Microsurgery (EFSM)
FX This paper is part of a Supplement supported by the European Federation
   of Societies of Microsurgery (EFSM).
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NR 24
TC 7
Z9 9
U1 0
U2 9
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2020
VL 51
SU 4
SI SI
BP S9
EP S15
DI 10.1016/j.injury.2020.03.027
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA PH6XS
UT WOS:000600553500003
PM 32284186
DA 2026-07-24
ER

PT J
AU Liu, H
   Zhang, G
   Wei, A
   Xing, H
   Han, CS
   Chang, ZQ
AF Liu, Huan
   Zhang, Ge
   Wei, An
   Xing, Hao
   Han, Changsheng
   Chang, Zhengqi
TI Effect of negative pressure wound therapy on the incidence of deep
   surgical site infections after orthopedic surgery: a meta-analysis and
   systematic review
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Review
DE Surgical site infections; Negative pressure wound therapy; Orthopedic
   procedures
ID RISK-FACTORS; FRACTURE SURGERY; HIP; DRESSINGS; INCISION; COMPLICATIONS;
   ARTHROPLASTY; PREVENTION; FIXATION
AB ObjectiveThis meta-analysis aimed to explore the impact of prophylactic negative pressure wound therapy (NPWT) on the occurrence of deep surgical site infections (SSIs) following orthopedic surgery.MethodsA systematic search was conducted across Medline, Embase, Cochrane Library, and Web of Science databases for articles concerning NPWT in patients who underwent orthopedic surgery up to May 20, 2024. Using Stata 15.0, the combined odds ratios (ORs) were calculated with either a random-effects model or a fixed-effects model, depending on the heterogeneity values.ResultsFrom a total of 440 publications, studies that utilized NPWT as the experimental group and conventional dressings as the control group were selected to analyze their impact on SSIs. Ultimately, 32 studies met the inclusion criteria. These included 12 randomized controlled trials and 20 cohort studies, involving 7454 patients, with 3533 of whom received NPWT and 3921 of whom were treated with conventional dressings. The results of the meta-analysis demonstrated that the NPWT group had a lower incidence of deep SSIs in orthopedic surgeries than did the control group [OR 0.64, 95% CI (0.52, 0.80), P = 0.0001]. Subgroup analysis indicated a notable difference for trauma surgeries [OR 0.65, 95% CI (0.50, 0.83), P = 0.001], whereas joint surgeries [OR 0.65, 95% CI (0.38, 1.12), P = 0.122] and spine surgeries [OR 0.61, 95% CI (0.27, 1.35), P = 0.221] did not show significant differences. Additionally, when examined separately according to heterogeneity, trauma surgeries exhibited a significant difference [OR 0.50, 95% CI (0.31, 0.80), P = 0.004].ConclusionThe results of our study indicate that the prophylactic use of NPWT reduces the incidence of deep SSIs following orthopedic trauma surgery when compared to the use of conventional dressings. We postulate that the prophylactic application of NPWT in patients at high risk of developing complications from bone trauma may result in improved clinical outcomes and an enhanced patient prognosis.
C1 [Liu, Huan; Zhang, Ge; Wei, An; Xing, Hao; Han, Changsheng; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan 250031, Shandong, Peoples R China.
   [Liu, Huan; Xing, Hao] Shandong Second Med Univ, Sch Clin Med, Weifang 261053, Shandong, Peoples R China.
   [Zhang, Ge; Wei, An; Han, Changsheng] Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China.
C3 Shandong Second Medical University; Shandong University of Traditional
   Chinese Medicine
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan 250031, Shandong, Peoples R China.
EM 26766771@qq.com
RI han, changsheng/HPC-6050-2023; hao, xing/ACN-7926-2022; liu,
   huan/NDS-1676-2025
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NR 75
TC 6
Z9 8
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD SEP 9
PY 2024
VL 19
IS 1
AR 555
DI 10.1186/s13018-024-05038-7
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA F4H7E
UT WOS:001309450500002
PM 39252068
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU D'Agostino, D
   Man, A
   Santacroce, L
AF D'Agostino, Donato
   Man, Adrian
   Santacroce, Luigi
TI CURRENT TRENDS IN CARDIAC SURGERY: CLINICAL EXPERIENCE IN THE TREATMENT
   OF MEDIASTINITIS WITH STERNAL WOUND INFECTION THROUGH NEGATIVE PRESSURE
   THERAPY
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Infective complications in cardiac surgery; Mediastinitis; Sternal wound
   infection and/or dehiscence; Negative Pressure Therapy and/or
   Vacuum-Assisted Closure Therapy (VAC Therapy)
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS;
   FREE-RADICALS; MANAGEMENT; COMPLICATIONS; ENDOCARDITIS; IRRIGATION;
   STERNOTOMY; HEART
AB Introduction: During the last decades, a general amelioration of clinical outcomes has been reported because of the evolution of cardiac surgery techniques. However, infective complications as mediastinitis still represent a major problem in terms of morbidity and mortality in cardiac surgery, with severe suffering of the patient. Furthermore, the incidence of this complication has remained stable over the last three decades and this condition also determines a significant prolongation of hospitalization with an increase in costs. The procedures used for the treatment of mediastinitis have undergone deep modifications over the years but, in despite of these improvements, mortality has remained high. Over the last years, the negative pressure therapy (ie the Vacuum Assisted Closure-Therapy) is taking over all the other treatments.
   Materials and method: From January 2010 to December 2015, at University of Bari Cardiac Surgery Center have been performed 3123 median sternotomy for cardiac surgery. Deep sternal wound infection occurred in 35 patients (1.1207%). In all of these patients was performed vacuum therapy.
   Results: The duration of vacuum treatment was 14.4 +/- 6.7 days. Inflammatory indexes showed a marked decline. At the end of vacuum therapy, in some cases, the reconstruction of the wound was carried out with plastic reconstruction by means of a pectoral flap. No deaths for mediastinitis were recorded, neither any relapse or treatment-related complication. Hospital stay was 30.4 +/- 13.5 days from the beginning of treatment.
   Conclusion: The results obtained in our center with vacuum therapy are much more better than those obtained with classic procedures used in the past. Based on our experience and from analysis of literature, vacuum therapy should be the procedure of choice for the treatment of post-sternotomy mediastinitis. Furthermore, this approach has shown satisfactory results in terms of hospital stay time and costs.
C1 [D'Agostino, Donato] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Sect Cardiac Surg, Bari, Italy.
   [Man, Adrian] Univ Med & Pharm Tirgu Mures, Microbiol, Targu Mures, Romania.
   [Santacroce, Luigi] Aldo Moro Univ Bari, Sch Hlth Profess, Bari, Italy.
   [Santacroce, Luigi] Aldo Moro Univ Bari, Lab Microbiol & Virol, Ionian Dept, DISGEM, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; George Emil Palade University
   of Medicine, Pharmacy, Science, & Technology of Targu Mures; Universita
   degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP D'Agostino, D (通讯作者)，Corso Vittorio Emanuele 143, I-70122 Bari, Italy.
EM d.dagostino@live.it
RI D'AGOSTINO, DONATO/B-1679-2012; Man, Adrian/M-3475-2016; Santacroce,
   Luigi/B-5466-2016
OI D'AGOSTINO, DONATO/0000-0001-5887-7655; Man, Adrian/0000-0001-5281-0601;
   
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NR 40
TC 5
Z9 5
U1 0
U2 2
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2016
VL 32
IS 6
BP 1905
EP 1910
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EF2SJ
UT WOS:000390174300025
DA 2026-07-24
ER

PT J
AU Ahmed, SS
   Diebold, KE
   Brandvold, JM
   Ewaidah, SS
   Black, S
   Ogundimu, A
   Li, ZY
   Stone, ND
   Van Beneden, CA
AF Ahmed, Sana S.
   Diebold, Kasey E.
   Brandvold, Jacob M.
   Ewaidah, Saadeh S.
   Black, Stephanie
   Ogundimu, Abimbola
   Li, Zhongya
   Stone, Nimalie D.
   Van Beneden, Chris A.
TI The Role of Wound Care in 2 Group A Streptococcal Outbreaks in a Chicago
   Skilled Nursing Facility, 2015-2016
SO OPEN FORUM INFECTIOUS DISEASES
LA English
DT Article
DE group A Streptococcus; healthcare-acquired infection; outbreak; wound
   infection; vacuum-assisted closure
ID UNITED-STATES; EPIDEMIOLOGY
AB Two consecutive outbreaks of group A Streptococcus (GAS) infections occurred from 2015-2016 among residents of a Chicago skilled nursing facility. Evaluation of wound care practices proved crucial for identifying transmission factors and implementing prevention measures. We demonstrated shedding of GAS on settle plates during care of a colonized wound.
C1 [Ahmed, Sana S.] Lake Cty Hlth Dept & Community Hlth Ctr, Communicable Dis, Waukegan, IL USA.
   [Diebold, Kasey E.] Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA.
   [Brandvold, Jacob M.] Washington State Univ, Coll Vet Med, Pullman, WA 99164 USA.
   [Ewaidah, Saadeh S.; Black, Stephanie] Chicago Dept Publ Hlth, Communicable Dis Program, Chicago, IL USA.
   [Ogundimu, Abimbola; Stone, Nimalie D.] Ctr Dis Control & Prevent, Div Hlth Qual & Promot, Atlanta, GA USA.
   [Li, Zhongya] Ctr Dis Control & Prevent, Grp Streptococcus Lab A, Atlanta, GA USA.
   [Van Beneden, Chris A.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA.
C3 Washington State University; Chicago Department of Public Health;
   Centers for Disease Control & Prevention - USA; Centers for Disease
   Control & Prevention - USA; Centers for Disease Control & Prevention -
   USA
RP Ahmed, SS (通讯作者)，Lake Cty Hlth Dept & Community Hlth Ctr, 3010 Grand Ave, Waukegan, IL 60085 USA.
EM sahmed@lakecountyil.gov
RI Li, Zhongya/JMQ-4363-2023
FU Respiratory Diseases Branch of the Centers for Disease Control and
   Prevention
FX This work was supported by the Respiratory Diseases Branch of the
   Centers for Disease Control and Prevention.
CR [Anonymous], 2015, GUIDELINE ISOLATION
   [Anonymous], GROUP A STREPT GAS D
   Beall B, 1996, J CLIN MICROBIOL, V34, P953, DOI 10.1128/JCM.34.4.953-958.1996
   Deutscher M, 2011, CLIN INFECT DIS, V52, P988, DOI 10.1093/cid/cir084
   Felkner M, 2005, INFECT CONT HOSP EP, V26, P462, DOI 10.1086/502568
   Jordan Hannah T., 2007, CLINICAL INFECTIOUS DISEASES, V45, P742, DOI [10.1086/520992, DOI 10.1086/520992]
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   O'Loughlin RE, 2007, CLIN INFECT DIS, V45, P853, DOI 10.1086/521264
NR 11
TC 9
Z9 10
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2328-8957
J9 OPEN FORUM INFECT DI
JI Open Forum Infect. Dis.
PD JUL
PY 2018
VL 5
IS 7
AR ofy145
DI 10.1093/ofid/ofy145
PG 4
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA GP5YK
UT WOS:000440953400013
PM 30680292
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ning, T
   Zha, ZG
AF Ning, Tao
   Zha, Zhen-Gang
TI Treatment of Morel-Lavallee Lesions (MLLs) with Mesh Incisions Combined
   with Quilting Sutures and Negative Pressure Wound Therapy (NPWT)
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
AB Purpose center dot The objective of this retrospective study was to evaluate the clinical effects of a novel treatment approach for Morel-Lavallee lesions (MLL) using a combination of suturing techniques and Negative Pressure Wound Therapy (NPWT) with mesh incisions. To summarize the clinical effects of a combination of suturing techniques and (Negative Pressure Wound Therapy) NPWT on the wall of Morel-Lavallee lesions ( MLL) fibrotic pseudocapsules with mesh incisions in the treatment of MLLs. A retrospective analysis was performed on MLL patients from April 2017 to March 2021.
   Methods center dot This a retrospective case-control study and thirteen MLL patients were included in this retrospective analysis conducted between April 2017 and March 2021, who were treated with mesh incisions on the wall of the pseudocapsule, quilting suturing to degloved soft tissues, and NPWT. Physical examination, MRI, or ultrasound before surgery confirmed the diagnosis. Wound healing, secondary infection, recurrence, visual analog scale (VAS) scores before and after surgery, and skin and soft tissue condition were observed and evaluated.
   Results center dot The combination of mesh incisions, quilting sutures, and NPWT led to successful wound healing in 11 out of 13 cases without recurrent hematoma or secondary infection. Visual analog scale (VAS) scores significantly decreased after the operation, and the aesthetic and tactile qualities of the injured area improved. One case of skin and soft tissue necrosis infection before the operation, which healed after second-stage full-thickness skin grafting, 1 case healed after a dressing change, and the remaining 11 cases had wounds that healed by the first stage without secondary infection or recurrent hematoma formation. VAS scores decreased significantly after the operation, the appearance of the injured area was as expected, and the skin feel and elasticity recovered satisfactorily.
   Conclusion center dot The study demonstrates that the mesh incision technique, along with mattress sutures and NPWT, presents a feasible and effective approach for treating MLL with fibrotic pseudocapsules. This could shorten healing times, reduce risk of complications, and improve patient satisfaction.
C1 [Ning, Tao; Zha, Zhen-Gang] Jinan Univ, Affiliated Hosp 1, Inst Orthoped Dis, Guangzhou, Guangdong, Peoples R China.
   [Ning, Tao; Zha, Zhen-Gang] Jinan Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Guangzhou, Guangdong, Peoples R China.
   [Ning, Tao; Zha, Zhen-Gang] Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Anhui, Peoples R China.
C3 Jinan University; Jinan University
RP Zha, ZG (通讯作者)，Jinan Univ, Affiliated Hosp 1, Inst Orthoped Dis, Guangzhou, Guangdong, Peoples R China.; Zha, ZG (通讯作者)，Jinan Univ, Affiliated Hosp 1, Dept Bone & Joint Surg, Guangzhou, Guangdong, Peoples R China.; Zha, ZG (通讯作者)，Fuyang Peoples Hosp, Dept Orthopaed Surg, Fuyang, Anhui, Peoples R China.
EM zhazhengang8277@163.com
NR 0
TC 2
Z9 3
U1 0
U2 1
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD NOV-DEC
PY 2023
VL 29
IS 8
BP 810
EP 813
PG 4
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EG1E0
UT WOS:001137669200135
PM 37773645
DA 2026-07-24
ER

PT J
AU Ker, H
   Al-Murrani, A
   Rolfe, G
   Martin, R
AF Ker, Helen
   Al-Murrani, Abbas
   Rolfe, Gill
   Martin, Richard
TI WOUND Study: A Cost-Utility Analysis of Negative Pressure Wound Therapy
   After Split-Skin Grafting for Lower Limb Skin Cancer
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Economic evaluation; Cost-utility
   analysis; Skin cancer; Split skin grafting
ID ASSISTED CLOSURE DEVICE; BURDEN
AB Background: Skin cancer rates in New Zealand are estimated to be the highest in the world. Split-skin grafting is a common procedure after skin cancer excision in the lower limb. We sought to evaluate the cost-effectiveness of negative pressure wound therapy (NPWT) with same-day discharge in patients undergoing split-skin grafting of the lower limb for the treatment of skin cancer.
   Materials and methods: Using effectiveness and quality of life data from a blinded, randomized single-center trial, a decision analytic model was developed from the perspective of the New Zealand hospital health-care buyer. The patient population included adults aged >18 y undergoing elective removal of lower limb skin cancer who were deemed able to manage a portable negative pressure device at home. A deterministic cost-effectiveness model was constructed using cost and utility data from our single-center Wound outcomes in negative pressure dressing (WOUND) trial. Forty-nine patients were randomized to receive either a negative pressure dressing applied in theater with same-day discharge home or a traditional bolster dressing with 5 d of inpatient bed rest. Patients were followed up for 3 mo to assess the mean percentage of graft take and complications. Quality of life was assessed through a EuroQoL questionnaire at 5-7 d. Cost data were collected directly from hospital records for each patient. Probabilistic sensitivity analysis was used to characterize uncertainty.
   Results: Compared with standard dressing, NPWT resulted in an average cost saving of $3903.28 per treatment and a disutility of 0.083. At a willingness-to-pay threshold of 25,000 New Zealand dollars, the incremental net benefit is $1828.27, indicating that NPWT is a cost-effective treatment option. The probability of NPWT being cost-effective was 73.15%.
   Conclusions: NPWT and same-day discharge in the appropriately selected patient is a cost-effective treatment compared with standard care. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Ker, Helen; Rolfe, Gill; Martin, Richard] Waitemata Dist Hlth Board, Dept Surg, 124 Shakespeare Rd, Auckland 0622, New Zealand.
   [Al-Murrani, Abbas] Waitemata & Auckland DHB, Planning Funding & Outcomes, Auckland, New Zealand.
   [Martin, Richard] Melanoma Unit, Auckland, New Zealand.
RP Ker, H (通讯作者)，Waitemata Dist Hlth Board, Dept Surg, 124 Shakespeare Rd, Auckland 0622, New Zealand.
EM helen.ker@hotmail.com
FU Intermed
FX This research received funding from Intermed but the funder had no role
   in study design, data collection, analysis or publication.
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NR 20
TC 13
Z9 16
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2019
VL 235
BP 308
EP 314
DI 10.1016/j.jss.2018.10.016
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI9LL
UT WOS:000456777000041
PM 30691811
DA 2026-07-24
ER

PT J
AU Hofmann, AT
   Gruber-Blum, S
   Lechner, M
   Petter-Puchner, A
   Glaser, K
   Fortelny, R
AF Hofmann, Anna Theresa
   Gruber-Blum, Simone
   Lechner, Michael
   Petter-Puchner, Alexander
   Glaser, Karl
   Fortelny, Ren
TI Delayed closure of open abdomen in septic patients treated with negative
   pressure wound therapy and dynamic fascial suture: the long-term
   follow-up study
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Secondary peritonitis; Open abdomen; Negative pressure wound therapy;
   Dynamic fascial suture; Delayed closure
ID VENTRAL HERNIA; MESH; TRACTION; INCISIONS
AB Negative pressure wound therapy (NPWT) is widely used in the treatment of open abdomen (OA). The use of dynamic fascial sutures (DFS) increases the rate of successful delayed closure by reducing fascial lateralization. We recently published a prospective controlled trial including 87 patients undergoing abdominal surgery for secondary peritonitis between 2007 and 2012. Patients were treated with NPWT and DFS for approximation of fascial edges. The present study represents a follow-up assessment of these patients 5-9 years after OA treatment with NPWT and DFS.
   The 39 patients still alive were included in the recent study according to the protocol of our last study in 2013. All patients received a questionnaire regarding long-term complications after OA treatment between 2007 and 2012. Mean follow-up was 5-9 years. Analyzed parameters included pain, the presence of incisional hernia, and subsequent surgical interventions. Results were analyzed quantitatively.
   One patient had deceased since the last publication in 2013, and hence 38 patients were included in the current study. The median age was 60.9 (25.2-86.1) years, and 17 (44.7%) were females. Overall 56.3% of the original 87 patients had died during the long-term follow-up period. 21 patients (55.3%) answered the questionnaire. Six (28.6%) declared that they suffered from pain in the previous operating field, five (23.8%) at rest, and three (14.3%) during exercise. In five patients (23.8%), pain lasted for more than 3 months. One patient (4.8%) still requires analgesic treatment. Among the 21 patients, seven (33.3%) were found to have incisional hernias. Three hernias (42.9%) were treated by surgery.
   Incisional hernia rates after OA treatment remain high, but are accompanied by little pain. The ideal technique of fascial closure after NPWT should be investigated in further research.
C1 [Hofmann, Anna Theresa; Gruber-Blum, Simone; Petter-Puchner, Alexander; Glaser, Karl; Fortelny, Ren] Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1160 Vienna, Austria.
   [Lechner, Michael] Paracelsus Med Univ, Dept Surg, Mullner Hauptstr 48, A-5020 Salzburg, Austria.
   [Fortelny, Ren] Sigmund Freud Univ, Freudpl 1, A-1020 Vienna, Austria.
C3 Wilhelminenspital; Paracelsus Private Medical University
RP Hofmann, AT (通讯作者)，Wilhelminenspital Stadt Wien, Dept Gen Visceral & Oncol Surg, Montleartstr 37, A-1160 Vienna, Austria.
EM anna.hofmann@wienkav.at
RI /S-5290-2019; Fortelny, René/AAD-5922-2021
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NR 19
TC 15
Z9 16
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2017
VL 31
IS 11
BP 4717
EP 4724
DI 10.1007/s00464-017-5547-4
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FL6NI
UT WOS:000414361700047
PM 28424908
DA 2026-07-24
ER

PT J
AU Cutting, K
   McGuire, J
AF Cutting, Keith
   McGuire, James
TI Safe, long-term management of bioburden that helps promote healing:
   Evidence review of DACC technology
SO JOURNAL OF WOUND CARE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; CELL-SURFACE
   HYDROPHOBICITY; INFECTIONS; BIOFILMS; STREPTOCOCCI; RESISTANCE; AGENTS;
   TRIAL
AB Unlike common antimicrobial dressings, the Cutimed Sorbact range does not kill pathogens, but instead binds them to its surface, so they can be safely removed at dressing change. As a result, it can be used long term with minimal risk of side effects. This supplement describes the evidence base on the efficacy of DACC technology.
C1 [Cutting, Keith] Buckinghamshire New Univ, High Wycombe, Bucks, England.
   [McGuire, James] Leonard Abrams Ctr Adv Wound Healing, Philadelphia, PA USA.
   [McGuire, James] Temple Univ, Sch Podiatr Med, Philadelphia, PA 19122 USA.
C3 Buckinghamshire New University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Temple University
RP Cutting, K (通讯作者)，Buckinghamshire New Univ, High Wycombe, Bucks, England.
RI Cutting, Keith/AAH-9434-2019
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NR 109
TC 9
Z9 10
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAY
PY 2015
VL 24
IS 5
SU S
BP S3
EP S30
PG 28
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8WG
UT WOS:000355783600001
PM 26079059
DA 2026-07-24
ER

PT J
AU Feier, CVI
   Gaborean, V
   Faur, IF
   Vonica, RC
   Faur, AM
   Rus, VI
   Dragan, BS
   Muntean, C
AF Feier, Catalin Vladut Ionut
   Gaborean, Vasile
   Faur, Ionut Flaviu
   Vonica, Razvan Constantin
   Faur, Alaviana Monique
   Rus, Vladut Iosif
   Dragan, Beniamin Sorin
   Muntean, Calin
TI A Systematic Review of Closed-Incision Negative-Pressure Wound Therapy
   for Hepato-Pancreato-Biliary Surgery: Updated Evidence, Context, and
   Clinical Implications
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE hepatectomy; surgical site infection; negative-pressure wound therapy;
   closed-incision; liver surgery; pancreatectomy
ID SURGICAL-SITE INFECTION; HIGH-RISK; PREVENTION
AB Background and Objectives: Postoperative pancreatic fistula and post-hepatectomy liver failure remain significant complications after HPB surgery; however, superficial surgical site infection (SSI) is the most frequent wound-related complication. Closed-incision negative-pressure wound therapy (ciNPWT) has been proposed to reduce superficial contamination, yet no liver-focused quantitative synthesis exists. We aimed to evaluate the effectiveness and safety of prophylactic ciNPWT after hepatopancreatobiliary (HPB) surgery. Methods: MEDLINE, Embase, and PubMed were searched from inception to 30 April 2025. Randomized and comparative observational studies that compared ciNPWT with conventional dressings after elective liver transplantation, hepatectomy, pancreatoduodenectomy, and liver resections were eligible. Two reviewers independently screened, extracted data, and assessed risk of bias (RoB-2/ROBINS-I). A random-effects Mantel-Haenszel model generated pooled risk ratios (RRs) for superficial SSI; secondary outcomes were reported descriptively. Results: Twelve studies (seven RCTs, five cohorts) encompassing 15,212 patients (3561 ciNPWT; 11,651 control) met the inclusion criteria. Device application lasted three to seven days in all trials. The pooled analysis demonstrated a 29% relative reduction in superficial SSI with ciNPWT (RR 0.71, 95% CI 0.63-0.79; p < 0.001) with negligible heterogeneity (I-2 0%). Absolute risk reduction ranged from 0% to 13%, correlating positively with the baseline control-group SSI rate. Deep/organ-space SSI (RR 0.93, 95% CI 0.79-1.09) and 90-day mortality (RR 0.94, 95% CI 0.69-1.28) were unaffected. Seven studies documented a 1- to 3-day shorter median length of stay; only two reached statistical significance. Device-related adverse events were rare (one seroma, no skin necrosis). Conclusions: Prophylactic ciNPWT safely reduces superficial SSI after high-risk HPB surgery, with the greatest absolute benefit when baseline SSI risk exceeds approximate to 10%. Its influence on deep infection and mortality is negligible.
C1 [Feier, Catalin Vladut Ionut] Victor Babes Univ Med & Pharm, Abdominal Surg & Phlebol Res Ctr, Timisoara 300041, Romania.
   [Feier, Catalin Vladut Ionut] Pius Brinzeu Clin Emergency Hosp, Surg Clin 1, Timisoara 300723, Romania.
   [Gaborean, Vasile] Victor Babes Univ Med & Pharm Timisoara, Thorac Surg Res Ctr, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Gaborean, Vasile] Victor Babes Univ Med & Pharm Timisoara, Dept Surg Semiol, Fac Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Faur, Ionut Flaviu] Timisoara Emergency Cty Hosp, IInd Surg Clin, Timisoara 300723, Romania.
   [Faur, Ionut Flaviu] Victor Babes Univ Med & Pharm Timisoara, Dept Gen Surg 10, Timisoara 300041, Romania.
   [Vonica, Razvan Constantin] Lucian Blaga Univ Sibiu, Fac Med, Preclin Dept, Sibiu 550169, Romania.
   [Vonica, Razvan Constantin] Elysee Hosp, Dept Oncol, Alba Iulia 510040, Romania.
   [Faur, Alaviana Monique; Rus, Vladut Iosif; Dragan, Beniamin Sorin] Victor Babes Univ Med & Pharm Timisoara, Fac Med, Timisoara 300041, Romania.
   [Muntean, Calin] Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci 3, Med Informat & Biostat, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Lucian Blaga University of Sibiu; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara
RP Gaborean, V (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Thorac Surg Res Ctr, Eftimie Murgu Sq 2, Timisoara 300041, Romania.; Gaborean, V (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Surg Semiol, Fac Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.; Faur, IF (通讯作者)，Timisoara Emergency Cty Hosp, IInd Surg Clin, Timisoara 300723, Romania.; Faur, IF (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Gen Surg 10, Timisoara 300041, Romania.
EM catalin.feier@umft.ro; vasile.gaborean@umft.ro; flaviu.faur@umft.ro;
   razvanconstantin.vonica@ulbsibiu.ro; alaviana.faur@student.umft.ro;
   iosif.rus@student.umft.ro; beniamin.dragan@student.umft.ro;
   cmuntean@umft.ro
RI Gaborean, Vasile/KMA-7364-2024; Feier, Catalin Vladut
   Ionut/LVS-1661-2024; Muntean, Calin/HHZ-8783-2022; Faur, Flaviu
   Ionuț/AAY-2592-2020; Vonica, Razvan/LZF-6780-2025
OI Gaborean, Vasile/0009-0000-8647-1003; Feier, Catalin Vladut
   Ionut/0000-0002-3277-1198; Muntean, Calin/0000-0002-0497-0405; Faur,
   Flaviu Ionuț/0000-0001-6451-7461; 
FU The "Victor Babes" University of Medicine and Pharmacy, Timisoara,
   Romania
FX The APC was funded by the "Victor Babes" University of Medicine and
   Pharmacy, Timisoara, Romania.
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NR 37
TC 7
Z9 7
U1 2
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL 22
PY 2025
VL 14
IS 15
AR 5191
DI 10.3390/jcm14155191
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6GL3D
UT WOS:001552763300001
PM 40806812
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hillis, LD
   Smith, PK
   Anderson, JL
   Bittl, JA
   Bridges, CR
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   Cigarroa, JE
   DiSesa, VJ
   Hiratzka, LF
   Hutter, AM Jr
   Jessen, ME
   Keeley, EC
   Lahey, SJ
   Lange, RA
   London, MJ
   Mack, MJ
   Patel, MR
   Puskas, JD
   Sabik, JF
   Selnes, O
   Shahian, DM
   Trost, JC
   Winniford, MD
AF Hillis, L. David
   Smith, Peter K.
   Anderson, Jeffrey L.
   Bittl, John A.
   Bridges, Charles R.
   Byrne, John G.
   Cigarroa, Joaquin E.
   DiSesa, Verdi J.
   Hiratzka, Loren F.
   Hutter, Adolph M., Jr.
   Jessen, Michael E.
   Keeley, Ellen C.
   Lahey, Stephen J.
   Lange, Richard A.
   London, Martin J.
   Mack, Michael J.
   Patel, Manesh R.
   Puskas, John D.
   Sabik, Joseph F.
   Selnes, Ola
   Shahian, David M.
   Trost, Jeffrey C.
   Winniford, Michael D.
TI 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery A
   Report of the American College of Cardiology Foundation/American Heart
   Association Task Force on Practice Guidelines
SO CIRCULATION
LA English
DT Article
DE AHA Scientific Statements; acute coronary syndromes; anticoagulants;
   antiplatelet agents; arrhythmias, cardiac; coronary angiography;
   coronary artery revascularization interventions: stents; drug therapy;
   heart diseases; myocardial revascularization; platelet aggregation
   inhibitor; ultrasound
ID INTERNAL-MAMMARY-ARTERY; LONG-TERM SURVIVAL; ACUTE
   MYOCARDIAL-INFARCTION; IN-HOSPITAL MORTALITY; ACUTE-RENAL-FAILURE;
   DRUG-ELUTING STENTS; HIGH-RISK PATIENTS; VACUUM-ASSISTED CLOSURE;
   NEW-YORK-STATE; RECOMBINANT-HUMAN-ERYTHROPOIETIN
C1 [Hillis, L. David; Lange, Richard A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
   [Smith, Peter K.] Duke Univ, Med Ctr Private Diagnost Clin, Durham, NC 27706 USA.
   [Bridges, Charles R.] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA.
   [Byrne, John G.] Vanderbilt Univ, Med Ctr Div Cardiac Surg, Nashville, TN 37235 USA.
   [Cigarroa, Joaquin E.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [DiSesa, Verdi J.] Johns Hopkins Univ Hosp, Div Cardiac Surg, Baltimore, MD 21287 USA.
   [Hutter, Adolph M., Jr.; Shahian, David M.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Jessen, Michael E.] UT SW Med Ctr, Dallas, TX USA.
   [Keeley, Ellen C.] Univ Virginia, Charlottesville, VA 22903 USA.
   [Lahey, Stephen J.] Univ Connecticut, Storrs, CT USA.
   [London, Martin J.] Univ Calif San Francisco, Vet Affairs Med Ctr, San Francisco, CA 94143 USA.
   [Patel, Manesh R.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
   [Puskas, John D.] Emory Univ Emory Healthcare, Atlanta, GA USA.
   [Sabik, Joseph F.] Cleveland Clin Fdn, Cleveland, OH USA.
   [Selnes, Ola] Johns Hopkins Univ Hosp, Dept Neurol, Baltimore, MD 21287 USA.
   [Trost, Jeffrey C.] Johns Hopkins Sch Med, Baltimore, MD USA.
   [Winniford, Michael D.] Univ Mississippi, Med Ctr, University, MS 38677 USA.
C3 University of Texas System; University of Texas at San Antonio; Duke
   University; University of Pennsylvania; Vanderbilt University; Oregon
   Health & Science University; Johns Hopkins University; Johns Hopkins
   Medicine; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; University of Texas System; University
   of Texas Southwestern Medical Center; University of Virginia; University
   of Connecticut; University of California System; University of
   California San Francisco; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Duke University; Cleveland Clinic
   Foundation; Johns Hopkins University; Johns Hopkins Medicine; Johns
   Hopkins University; Johns Hopkins Medicine; University of Mississippi
   Medical Center; University of Mississippi
RP Hillis, LD (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
RI Lange, Richard/AAM-9594-2021; Patel, Manesh/AAC-5385-2019
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NR 1259
TC 416
Z9 470
U1 0
U2 48
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD DEC 6
PY 2011
VL 124
IS 23
BP E652
EP U267
DI 10.1161/CIR.0b013e31823c074e
PG 176
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 863QW
UT WOS:000298183300002
PM 22064599
OA Bronze
DA 2026-07-24
ER

PT J
AU Wardell, C
   Whitworth, S
   Wolfe, J
AF Wardell, Cooper
   Whitworth, Steven
   Wolfe, Jennifer
TI Buttock Necrosis Following Uterine Artery Embolization: A Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE fibroid; leiomyoma; necrosis; negative pressure wound therapy; uterine
   artery embolization
AB Background. Uterine artery embolization (UAE) is an increasingly common procedure for the management of uterine leiomyoma (fibroid). Up to 70% of White women and more than 80% of women of African ancestry will develop benign fibroid tumors of the uterus, many of whom will have symptoms including increased menstrual bleeding, urinary symptoms, pain, and infertility. When medical management does not adequately treat symptoms, UAE is a minimally invasive surgical treatment option. Nontarget embolization is a rare complication of this procedure and can result in soft tissue necrosis. Few case reports describe this phenomenon. Case Report. A 46-year-old female presented to the wound clinic 5 months after UAE. Following this procedure, the patient developed burning pain in the thigh and buttock. After 5 weeks, a small eschar formed over the right buttock, which progressed to a large necrotic ulceration. The patient was treated successfully, with wound closure by secondary intention occurring 24 weeks after initial presentation. Treatment included sharp debridement, advanced dressings, oral antibiotics (for infection), and negative pressure wound therapy. Conclusion. This case adds to the body of literature describing a full-thickness wound forming due to nontarget embolization. The patient was treated successfully in clinic without the need for further surgery or inpatient treatment.
C1 [Wardell, Cooper; Whitworth, Steven; Wolfe, Jennifer] Piedmont Rockdale Hosp, Wound Care & Hyperbar Ctr, Conyers, GA USA.
RP Wardell, C (通讯作者)，Piedmont Rockdale Hosp, Wound Care, 1412 Milstead Ave, Conyers, GA 30012 USA.
EM cooper.wardell@gmail.com
CR Armstrong AA, 2019, J MINIM INVAS GYN, V26, P667, DOI 10.1016/j.jmig.2018.07.006
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   Dietz DM, 2004, OBSTET GYNECOL, V104, P1159, DOI 10.1097/01.AOG.0000141567.25541.26
   Gerhard-Herman MD, 2017, CIRCULATION, V135, pE726, DOI 10.1161/CIR.0000000000000471
   Giuliani E, 2020, INT J GYNECOL OBSTET, V149, P3, DOI 10.1002/ijgo.13102
   Green AN, 2019, J MINIM INVAS GYN, V26, P354, DOI 10.1016/j.jmig.2018.05.015
   Gupta JK, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005073.pub4
   Himiniuc LM, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57020083
   Kaufman C, 2020, Currently available embolics for uterine fibroid embolization, V19, P60
   Kottner J, 2019, J TISSUE VIABILITY, V28, P51, DOI 10.1016/j.jtv.2019.01.001
   Psilopatis I, 2023, ROFO-FORTSCHR RONTG, V195, P890, DOI 10.1055/a-2077-1387
   Rand T, 2020, CVIR ENDOVASC, V3, DOI 10.1186/s42155-020-00174-7
   Schirf Brian E, 2006, Semin Intervent Radiol, V23, P143, DOI 10.1055/s-2006-941444
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   Zimmermann A, 2012, BMC WOMENS HEALTH, V12, DOI 10.1186/1472-6874-12-6
NR 15
TC 0
Z9 0
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2025
VL 37
IS 1
BP 1
EP 4
DI 10.25270/wnds/24025
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0M4E
UT WOS:001429174500001
PM 39982382
DA 2026-07-24
ER

PT J
AU Rawson, KB
   Neuberger, T
   Smith, T
   Reddy, HRK
   Haussener, TJ
   Sebahar, PR
   Looper, RE
   Isaacson, BM
   Shero, J
   Pasquina, PF
   Williams, DL
AF Rawson, Kaden B.
   Neuberger, Travis
   Smith, Tyler
   Reddy, Hariprasada Reddy Kanna
   Haussener, Travis J.
   Sebahar, Paul R.
   Looper, Ryan E.
   Isaacson, Brad M.
   Shero, John
   Pasquina, Paul F.
   Williams, Dustin L.
TI Antibiofilm potential of a negative pressure wound therapy foam loaded
   with a first-in-class tri-alkyl norspermidine-biaryl antibiotic
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE antimicrobial; drug delivery; release; hydrogel; polyurethane(s); wound
   healing
ID ELUTION KINETICS; COMPLICATIONS
AB Negative-pressure wound therapy (NPWT) is commonly utilized to treat traumatic injuries sustained on the modern battlefield. However, NPWT has failed to decrease the incidence of deep tissue infections experienced by Wounded Warriors, despite attempts to integrate common antimicrobials, like Ag+ nanoparticles, into the wound dressing. The purpose of this study was to incorporate a unique antibiofilm compound (CZ-01179) into the polyurethane matrix of NPWT foam via lyophilized hydrogel scaffolding. Foam samples with 2.5%, 5.0%, and 10.0% w/w CZ-01179 were produced and antibiofilm efficacy was compared to the current standards of care: V.A.C.(R) GRANUFOAM SILVER (TM) and V.A.C.(R) GRANUFOAM (TM). Gravimetric analysis and elution kinetics testing confirmed that this loading technique was both repeatable and controllable. Furthermore, zone of inhibition and antibiofilm efficacy testing showed that foam loaded with CZ-01179 had significantly increased activity against planktonic and biofilm phenotypes of methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii compared to the clinical standards. These findings motivate additional ex vivo and in vivo work with NPWT foam loaded with CZ-01179 with the overall objective of reducing NPWT-associated infections that complicate battlefield-related and other wounds.
C1 [Rawson, Kaden B.; Neuberger, Travis; Smith, Tyler; Williams, Dustin L.] Univ Utah, Dept Orthopaed, 20 S 2030 E,Biopolymers Res Bldg,Room 205, Salt Lake City, UT 84112 USA.
   [Reddy, Hariprasada Reddy Kanna; Haussener, Travis J.; Sebahar, Paul R.; Looper, Ryan E.; Williams, Dustin L.] Curza Global, Salt Lake City, UT USA.
   [Sebahar, Paul R.; Looper, Ryan E.] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
   [Isaacson, Brad M.] Geneva Fdn, Washington, DC USA.
   [Isaacson, Brad M.; Shero, John; Pasquina, Paul F.; Williams, Dustin L.] Uniformed Serv Univ Hlth Sci, Ctr Rehabil Sci Res, Dept Phys Med & Rehabil, Bethesda, MD 20814 USA.
   [Shero, John] Extrem Trauma & Amputat Ctr Excellence, San Antonio, TX USA.
   [Pasquina, Paul F.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD USA.
   [Williams, Dustin L.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Williams, Dustin L.] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; Uniformed Services University of
   the Health Sciences - USA; Walter Reed National Military Medical Center;
   Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Williams, DL (通讯作者)，Univ Utah, Dept Orthopaed, 20 S 2030 E,Biopolymers Res Bldg,Room 205, Salt Lake City, UT 84112 USA.
EM dustin.williams@utah.edu
RI /ABH-4895-2020
OI Rawson, Kaden/0000-0003-2649-6860
FU Center for Rehabilitation Sciences Research Award [HU0001-15-2-0003]
FX Center for Rehabilitation Sciences Research Award, Grant/Award Number:
   HU0001-15-2-0003
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NR 23
TC 4
Z9 5
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2022
VL 110
IS 8
BP 1780
EP 1788
DI 10.1002/jbm.b.35035
EA FEB 2022
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 2Y0FG
UT WOS:000760963100001
PM 35213779
DA 2026-07-24
ER

PT J
AU Mascarenhas, DC
   Nasra, M
   Tawfik, A
   Ghazi, J
   Ishmael, T
   Therrien, PJ
   Bowe, JA
   Tuason, D
AF Mascarenhas, Daniel C.
   Nasra, Matthew
   Tawfik, Amr
   Ghazi, John
   Ishmael, Terrence
   Therrien, Phillip J.
   Bowe, John A.
   Tuason, Dominick
TI Incisional Negative Pressure Wound Therapy Does Not Affect Deep Surgical
   Site Infection Rates in Neuromuscular Scoliosis Surgery
SO ORTHOPEDICS
LA English
DT Article
ID SPINAL-FUSION; RISK-FACTORS; COMPLICATIONS; CHILDREN
AB Surgical site infection (SSI) is a devastating complication in patients with neuromuscular scoliosis (NMS) undergoing posterior spinal instrumented fusion (PSIF) for progressive scoliosis. Incisional negative pressure wound therapy (INPWT) has been used in other surgical fields to reduce SSI. Our purpose was to examine the prophylactic use of INPWT after NMS surgery to decrease SSI. At a single institution, 71 consecutive patients with NMS underwent PSIF from 2015 to 2019. Starting in 2017, all patients with NMS received INPWT postoperatively until discharge. Rates of deep SSI were compared between the two cohorts of patients. Additionally, patient demographic and operative factors such as American Society of Anesthesiologists score, number of levels instrumented, need for an anterior spinal release, need for spinal fusion to pelvis, blood loss, operative time, fluoroscopy time, length of stay, and transfusion requirement were analyzed for potential influence on deep SSI. There was no significant difference in deep SSI rates between patients who received INPWT (2 of 41) and those treated with a standard postoperative dressing (2 of 30; P=1.0). Although INPWT theoretically can stabilize the wound environment and prevent deep SSI, our findings do not support this. More research is needed to evaluate the efficacy of INPWT after PSIF for NMS.
C1 [Mascarenhas, Daniel C.; Nasra, Matthew; Tawfik, Amr; Ghazi, John; Ishmael, Terrence; Therrien, Phillip J.; Bowe, John A.] Rutgers State Univ, Dept Orthopaed, Rutgers Robert Wood Johnson Med Sch, 52 French St,MEB 422, New Brunswick, NJ 08901 USA.
   [Tuason, Dominick] Yale Univ, Yale Sch Med, Dept Orthopaed, New Haven, CT USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Yale University
RP Mascarenhas, DC (通讯作者)，Rutgers State Univ, Dept Orthopaed, Rutgers Robert Wood Johnson Med Sch, 52 French St,MEB 422, New Brunswick, NJ 08901 USA.
EM daniel-mascarenhasorthopaedic@gmail.com
CR Aleissa S, 2011, CAN J SURG, V54, P263, DOI 10.1503/cjs.008210
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NR 21
TC 4
Z9 6
U1 0
U2 1
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV-DEC
PY 2023
VL 46
IS 6
BP 373
EP 378
DI 10.3928/01477447-20230329-03
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GK1V8
UT WOS:001152481600018
PM 37018618
DA 2026-07-24
ER

PT J
AU Qiu, R
   Johal, H
AF Qiu, Reva
   Johal, Herman
TI Cochrane in CORR®: Negative Pressure Wound Therapy for Surgical
   Wounds Healing by Primary Closure
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Editorial Material
ID INFECTION
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.
   Objectives
   To assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.
   Search methods
   In January 2021, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.
   Selection criteria
   We included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another.
   Data collection and analysis
   At least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane risk of bias tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology. Our primary outcomes were SSI, mortality, and wound dehiscence.
C1 [Qiu, Reva] McMaster Univ, Michael G DeGroote Sch Med, Hamilton, ON, Canada.
   [Johal, Herman] McMaster Univ, Dept Surg, Div Orthoped Surg, Hamilton, ON L8L 8E7, Canada.
C3 McMaster University; McMaster University
RP Johal, H (通讯作者)，McMaster Univ, Dept Surg, Div Orthoped Surg, Hamilton, ON L8L 8E7, Canada.
EM johal@medportal.ca
OI Johal, Herman/0000-0003-0643-534X
CR Andersen B., 2019, Prevention and Control of Infections in Hospitals: Practice and Theory
   Clinicaltrials.gov, EFFECT NEGATIVE PRES
   Clinicaltrials.gov, SURG APPL VAC DRESSI
   Clinicaltrials.gov, PREVENTION WOUND COM
   Clinicaltrials.gov, INCISIONAL NEGATIVE
   Clinicaltrials.gov, EFFICACY NEGATIVE PR
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NR 20
TC 2
Z9 2
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD SEP
PY 2022
VL 480
IS 9
BP 1646
EP 1652
DI 10.1097/CORR.0000000000002313
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 3V3ES
UT WOS:000841548200004
PM 35930683
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Sáez-Martín, LC
   García-Martínez, L
   Román-Curto, C
   Sánchez-Hernández, MV
   Suárez-Fernández, RM
AF Saez-Martin, Luis C.
   Garcia-Martinez, Lourdes
   Roman-Curto, Concepcion
   Sanchez-Hernandez, Miguel V.
   Suarez-Fernandez, Ricardo M.
TI Negative pressure and nanocrystalline silver dressings for nonhealing
   ulcer: A randomized pilot study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID WOUND THERAPY; BIOFILMS; MANAGEMENT; EFFICACY; SAFETY
AB Chronic wounds have a high prevalence and wound care, treatment, and prevention consume large quantities of resources. Chronic wounds are a growing challenge for clinicians. A prospective randomized pilot study was conducted to assess the effectiveness in terms of reduction in area and safety of the combined use of negative-pressure wound therapy and nanocrystalline silver dressings as compared to negative pressure wound therapy (NPWT) alone in the management of outpatients with chronic wounds. A total of 17 patients were included in the study, 10 were treated with the combined method and 7 with NPWT. Patients were followed for 6 weeks, with a final assessment at 3 months. Clinical improvement, microbiologic data, and toxicity of silver were evaluated. The antibacterial effects of ionic silver together with the development of granulation tissue promoted by NPWT reduced significantly the median extension of the wound between weeks 3 and 6 of treatment. The combination with silver also reduced bacterial colonization with Pseudomonas aeruginosa and the bacterial load on the surface of the wound. The silver levels correlated positively with the extension of the wound, although in none of the patients' toxic levels were reached. The combination of NPWT with nanocrystalline silver dressings was safe and as effective as NPWT alone.
C1 [Saez-Martin, Luis C.; Suarez-Fernandez, Ricardo M.] Gen Univ Hosp Gregorio Maranon, Dept Dermatol, Madrid, Spain.
   [Garcia-Martinez, Lourdes] Univ Hosp Salamanca, Dept Plast Surg, Salamanca, Spain.
   [Roman-Curto, Concepcion] Univ Hosp Salamanca, Dept Dermatol, Salamanca, Spain.
   [Sanchez-Hernandez, Miguel V.] Univ Hosp Salamanca, Dept Anesthesiol, Salamanca, Spain.
C3 General University Gregorio Maranon Hospital; University of Salamanca;
   University of Salamanca
RP Sáez-Martín, LC (通讯作者)，C Doctor Esquerdo 46, E-28007 Madrid, Spain.
EM lcsaezmartin@gmail.com
RI suarez-fernandez, ricardo/D-4201-2014
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NR 23
TC 8
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2015
VL 23
IS 6
BP 948
EP 952
DI 10.1111/wrr.12358
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CX5EO
UT WOS:000365725100018
PM 26299899
DA 2026-07-24
ER

PT J
AU Kääriäinen, M
   Kuokkanen, H
AF Kaariainen, M.
   Kuokkanen, H.
TI PRIMARY CLOSURE OF THE ABDOMINAL WALL AFTER "OPEN ABDOMEN" SITUATION
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal compartment syndrome; open abdomen; primary closure;
   components separation; biologic; synthetic; mesh; perforator saving;
   negative pressure wound therapy; perforator saving components separation
ID ACELLULAR DERMAL MATRIX; ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME;
   FASCIAL CLOSURE; SEPARATION; RECONSTRUCTION; COMPLEX; REPAIR
AB "Open abdomen" is a strategy used to avoid or treat abdominal compartment syndrome. It has reduced mortality both in trauma and non-trauma abdominal catastrophes but also has created a challenging clinical problem. Traditionally, open abdomen is closed in two phases; primarily with a free skin graft and later with a flap reconstruction. A modern trend is to close the abdomen within the initial hospitalization. This requires multi-professional co-operation. Temporary abdominal closure methods, e.g. negative pressure wound therapy alone or combined with mesh-mediated traction, have been developed to facilitate direct fascial closure. Components separation technique, mesh reinforcement or bridging of the fascial defect with mesh and perforator saving skin undermining can be utilized in the final closure if needed. These techniques can be combined. Choice of the treatment depends on the condition of the patient and size of the fascia and skin defect, and the state of the abdominal contents. In this paper we review the literature on the closure of an open abdomen and present the policy used in our institution in the open abdomen situations.
C1 [Kaariainen, M.; Kuokkanen, H.] Tampere Univ Hosp, Dept Plast Surg, FI-33521 Tampere, Finland.
C3 Tampere University; Tampere University Hospital
RP Kääriäinen, M (通讯作者)，Tampere Univ Hosp, Dept Plast & Reconstruct Surg, POB 2000, FI-33521 Tampere, Finland.
EM minna.t.kaariainen@gmail.com
RI /M-6470-2013
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NR 29
TC 13
Z9 17
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2013
VL 102
IS 1
BP 20
EP 24
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 129YX
UT WOS:000317881000005
PM 23628632
DA 2026-07-24
ER

PT J
AU Älgå, A
   Löfgren, J
   Haweizy, R
   Bashaireh, K
   Wong, S
   Forsberg, BC
   von Schreeb, J
   Malmstedt, J
AF Alga, Andreas
   Lofgren, Jenny
   Haweizy, Rawand
   Bashaireh, Khaldoon
   Wong, Sidney
   Forsberg, Birger C.
   von Schreeb, Johan
   Malmstedt, Jonas
TI Cost analysis of negative-pressure wound therapy versus standard
   treatment of acute conflict-related extremity wounds within a randomized
   controlled trial
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Trauma; Armed conflict; Wounds; Cost analysis
AB Background Clinical outcomes after negative-pressure wound therapy (NPWT) and standard treatment of conflict-related extremity wounds are similar. In resource-limited settings, cost affects the choice of treatment. We aimed to estimate treatment-related costs of NPWT in comparison with standard treatment for conflict-related extremity wounds. Methods We derived outcome data from a randomized, controlled superiority trial that enrolled adult (>= 18 years) patients with acute (<= 72 h) conflict-related extremity wounds at two civilian hospitals in Jordan and Iraq. Primary endpoint was mean treatment-related healthcare costs (adjusted to 2019 US dollars). Results Patients were enrolled from June 9, 2015, to October 24, 2018. A total of 165 patients (155 men [93.9%]; 10 women [6.1%]; and median [IQR] age, 28 [21-34] years) were included in the analysis. The cost per patient treated with NPWT was $142 above that of standard treatment. Overall, results were robust in a sensitivity analysis. Conclusions With similar clinical outcomes compared to standard care, our results do not support the use of NPWT in routine treatment of conflict-related extremity wounds at civilian hospitals in resource scarce settings. Trial registration NCT02444598.
C1 [Alga, Andreas; Malmstedt, Jonas] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
   [Alga, Andreas; Forsberg, Birger C.; von Schreeb, Johan] Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
   [Lofgren, Jenny] Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
   [Haweizy, Rawand] Hawler Med Univ, Coll Med, Erbil 400112, Iraq.
   [Bashaireh, Khaldoon] Jordan Univ Sci & Technol, Dept Special Surg, Irbid 22110, Jordan.
   [Bashaireh, Khaldoon] Yarmouk Univ, Med Fac, Irbid 21163, Jordan.
   [Wong, Sidney] Operat Ctr Amsterdam, Med Sans Frontieres, Plantage Middenlaan 14, NL-1018 DD Amsterdam, Netherlands.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Karolinska Institutet; Hawler Medical University; Jordan University of
   Science & Technology; Yarmouk University; Doctors Without Borders
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Sjukhusbacken 10, S-11883 Stockholm, Sweden.; Älgå, A (通讯作者)，Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
EM andreas.alga@ki.se
RI ; Älgå, Andreas/B-1070-2019; Löfgren, Jenny/J-6694-2019
OI Malmstedt, Jonas/0000-0002-2758-9623; Älgå, Andreas/0000-0001-5245-7668;
   
FU Karolinska Institute; Stockholm County Council [ALF 20160207]; Swedish
   National Board of Health and Welfare [10.1-30118/2019]; Medecins Sans
   Frontieres
FX Open access funding provided by Karolinska Institute. This work was
   supported by the Stockholm County Council (ALF 20160207), the Swedish
   National Board of Health and Welfare (10.1-30118/2019), and Medecins
   Sans Frontieres. No companies were involved in any part of the trial,
   nor did any companies contribute funding. The funders had no role in
   study design, data collection, data analysis, data interpretation, or
   writing of the report.
CR Aboutanos MB, 1997, J TRAUMA, V43, P719, DOI 10.1097/00005373-199710000-00031
   Älgå A, 2020, LANCET GLOB HEALTH, V8, pE423, DOI 10.1016/S2214-109X(19)30547-9
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NR 18
TC 12
Z9 14
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD FEB 10
PY 2022
VL 17
IS 1
AR 9
DI 10.1186/s13017-022-00415-1
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA YX1DX
UT WOS:000753849900001
PM 35144650
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU FLEISCHMANN, W
   STRECKER, W
   BOMBELLI, M
   KINZL, L
AF FLEISCHMANN, W
   STRECKER, W
   BOMBELLI, M
   KINZL, L
TI VACUUM SEALING FOR TREATMENT OF SOFT-TISSUE INJURY IN OPEN FRACTURES
SO UNFALLCHIRURG
LA German
DT Article
AB In 1992, 15 of 152 patients with open fractures were treated with vacuum sealing. Drainage tubes are inserted into polyvinyl foam, which is used to fill in the wound or tissue defect. Polyvinyl foam and adjacent skin are covered with a transparent polyurethane dressing which is impermeable to bacteria. The connection of the drainage tubes to a suction device, such as vacuum bottles, produces negative pressure in the polyvinyl foam, which means a high-contact zone of the foam-wound interface. This results in efficient cleaning and conditioning of the wound, with marked proliferation of granulation tissue. Bone infection did not occur in any of our 15 patients; 1 patient sustained a soft tissue infection due to an insufficient sealing technique. When the correct technique was applied the infection cleared up.
RP FLEISCHMANN, W (通讯作者)，UNIV ULM,UNFALL HAND PLAST & WIEDERHERSTELLUNGSCHIRURG KLIN,STEINHOVELSTR 9,D-89075 ULM,GERMANY.
NR 0
TC 334
Z9 542
U1 1
U2 43
PU SPRINGER VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD SEP
PY 1993
VL 96
IS 9
BP 488
EP 492
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA LZ028
UT WOS:A1993LZ02800009
PM 8235687
DA 2026-07-24
ER

PT J
AU Ma, Y
   Tang, JS
   Wang, F
   Liu, EB
   Zuo, JL
AF Ma, Yang
   Tang, Jinshuo
   Wang, Fei
   Liu, Enbo
   Zuo, Jianlin
TI Case report: A case of severe lower limb necrotizing fasciitis caused by
   an insulin injection has been reported
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE necrotizing fasciitis; <italic>Escherichia coli</italic>; finger
   separation test; vacuum sealing drainage; diabetes; insulin injection
ID INFECTION; SITE
AB Necrotizing fasciitis (NF) is a rare but life-threatening soft tissue infection, often accompanied by severe systemic toxicity. Early detection and prompt treatment are critical for survival. We report a case of NF in a 53-year-old diabetic woman following a subcutaneous insulin injection in the thigh. The patient presented with severe local pain as the initial symptom, and Escherichia coli was the sole isolated pathogen, which is seldom reported in the current literature. We combined with existing literature and clinical manifestations observed in NF patients at our hospital, offer valuable guidance for clinicians in recognizing and responding to NF.
C1 [Ma, Yang; Tang, Jinshuo; Wang, Fei; Liu, Enbo; Zuo, Jianlin] Jilin Univ, China Japan Union Hosp, Dept Orthoped, Changchun, Peoples R China.
C3 Jilin University
RP Zuo, JL (通讯作者)，Jilin Univ, China Japan Union Hosp, Dept Orthoped, Changchun, Peoples R China.
EM zuojl@jlu.edu.cn
FU Science and Technology Development Program of Jilin Province
   [YDZJ202201ZYTS520]; Department of Finance of Jilin Province [2023SCZ89,
   2022SCZ03]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. The study was
   financially supported by the Science and Technology Development Program
   of Jilin Province (No. YDZJ202201ZYTS520), the Department of Finance of
   Jilin Province (Nos. 2023SCZ89, 2022SCZ03).
CR BROOK I, 1995, J CLIN MICROBIOL, V33, P2382, DOI 10.1128/JCM.33.9.2382-2387.1995
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NR 19
TC 0
Z9 0
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JAN 7
PY 2025
VL 11
AR 1514241
DI 10.3389/fmed.2024.1514241
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA S7J9V
UT WOS:001399950100001
PM 39839632
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhou, ZY
   Liu, YK
   Chen, HL
   Liu, F
AF Zhou, Zhen-Yu
   Liu, Ya-Ke
   Chen, Hong-Lin
   Liu, Fan
TI Prevention of Surgical Site Infection After Ankle Surgery Using
   Vacuum-Assisted Closure Therapy in High-Risk Patients With Diabetes
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE ankle surgery; diabetes mellitus; standard moist wound care; surgical
   site infection; vacuum-assisted closure
ID NEGATIVE-PRESSURE THERAPY; OUTCOMES; FOOT; FRACTURES; MELLITUS
AB Patients with diabetes have a high risk of surgical site infection (SSI) after ankle surgery. The aim of the present study was to investigate the efficacy of vacuum-assisted closure (VAC) in the prevention of SSI after ankle surgery compared with the efficacy of standard moist wound care (SMWC). A retrospective study was performed of unstable ankle fractures for surgical fixation in patients with diabetes from January 2012 to December 2014. VAC and SMWC were used for surgical incision coverage. The primary outcome was the incidence of SSI, and the secondary outcomes were the length of hospital stay and crude hospital costs. The data from 76 patients were analyzed, with 22 (28.95%) in the VAC group and 54 (71.05%) in the SMWC group. The incidence of SSI was 4.6% in the VAC group compared with 27.8% in the SMWC group (chi-square 5.076; p = .024), and the crude odds ratio for SSI in the VAC group was 0.124 (95% confidence interval 0.002 to 0.938). The length of hospital stay was lower in the VAC group than in the SMWC group (12.6 +/- 2.7 days and 15.2 +/- 3.5 days, respectively; t = 3.122, p = .003). The crude hospital costs were also lower in the VAC group than in the SMWC group (Chinese yuan 8643.2 +/- 1195.3 and 9456.2 +/- 1106.3, respectively; t = 2.839, p = .006). After logistic regression analysis, the adjusted odds ratio for the total SSI rate comparing VAC and SMWC was 0.324 (95% confidence interval 0.092 to 0.804; p = .021). Compared with SMWC, VAC can decrease the SSI rate after ankle surgery in patients with diabetes. This finding should be confirmed by prospective, randomized controlled clinical trials. (C) 2016 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Zhou, Zhen-Yu; Liu, Ya-Ke; Liu, Fan] Nantong Univ, Affiliated Hosp, Dept Orthopaed, Nantong, Peoples R China.
   [Chen, Hong-Lin] Nantong Univ, Nantong City 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Liu, F (通讯作者)，Nantong Univ, Affiliated Hosp, Dept Orthopaed, Xisi Rd 20, Nantong City 226001, Jiangsu, Peoples R China.
EM pphss@126.com
RI ; Chen, Hong-Lin/E-5418-2010
OI Liu, Fan/0000-0002-4967-7595; 
CR Blackham AU, 2013, AM J SURG, V205, P647, DOI 10.1016/j.amjsurg.2012.06.007
   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
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NR 15
TC 19
Z9 21
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2016
VL 55
IS 1
BP 129
EP 131
DI 10.1053/j.jfas.2015.08.013
PG 3
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CZ4KF
UT WOS:000367071200029
PM 26603948
DA 2026-07-24
ER

PT J
AU Sandy-Hodgetts, K
   Leslie, GD
   Parsons, R
   Zeps, N
   Carville, K
AF Sandy-Hodgetts, K.
   Leslie, G. D.
   Parsons, R.
   Zeps, N.
   Carville, K.
TI Prevention of postsurgical wound dehiscence after abdominal surgery with
   NPWT: a multicentre randomised controlled trial protocol
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE surgical wound dehiscence; efficacy; negative pressure wound therapy;
   randomised controlled trial; economic cost analysis
ID THERAPY
AB Objective: The effectiveness of negative pressure wound therapy (NPWT) in the prevention of postoperative surgical wound dehiscence (SWD) is the subject of much debate and remains to be determined. This study will identify individuals at risk of postoperative SWD and trial the use of NPWT as a prophylactic measure against the occurrence of SWD, compared with a nonNPWT standard surgical dressing (SSD).
   Method: A prospective multicentre randomised controlled trial comparing NPWT dressing against standard surgical dressings (SSD) will be conducted. An intention-to-treat (ITT) approach will be used for the trial.
   Aims: The primary outcome is the prevention of postoperative SWD up to and including day 30 postoperative. Secondary outcomes are: prevention of surgical site infection (SSI) and economic analysis of treatment groups.
   Conclusion: This study will determine the effectiveness of NPWT in the prevention of postoperative abdominal SWD in a predefined level of risk population. This level 1 study will provide further data for abdominal SWD risk classification, which is anticipated to inform preventive postoperative management. The study design uses a prospective real-world scenario in order to identify clinically significant differences between the intervention and control groups.
C1 [Sandy-Hodgetts, K.; Leslie, G. D.] Curtin Univ, Sch Nursing & Midwifery, Perth, WA, Australia.
   [Sandy-Hodgetts, K.] Univ Western Australia, Sch Anat Physiol & Human Biol, Perth, WA, Australia.
   [Sandy-Hodgetts, K.; Leslie, G. D.; Carville, K.] Wound Management Innovat Cooperat Res Ctr, West End, Qld, Australia.
   [Parsons, R.] Curtin Univ, Sch Occupat Therapy & Social Work, Perth, WA, Australia.
   [Parsons, R.] Curtin Univ, Sch Pharm, Perth, WA, Australia.
   [Zeps, N.] Curtin Univ, Sch Hlth Sci, Perth, WA, Australia.
   [Zeps, N.] Murdoch Univ, Ctr Comparat Genom, Perth, WA, Australia.
   [Zeps, N.] Univ Western Australia, Sch Pathol & Lab Med, Perth, WA, Australia.
   [Zeps, N.] Univ Western Australia, Colorectal Canc Res Unit, Perth, WA, Australia.
   [Zeps, N.] Univ Notre Dame Australia, Sch Med, Fremantle, WA, Australia.
   [Carville, K.] Silver Chain Grp, Fremantle, WA, Australia.
C3 Curtin University; University of Western Australia; Curtin University;
   Curtin University; Curtin University; Murdoch University; University of
   Western Australia; University of Western Australia; The University of
   Notre Dame Australia
RP Sandy-Hodgetts, K (通讯作者)，Curtin Univ, Sch Nursing & Midwifery, Perth, WA, Australia.; Sandy-Hodgetts, K (通讯作者)，Univ Western Australia, Sch Anat Physiol & Human Biol, Perth, WA, Australia.; Sandy-Hodgetts, K (通讯作者)，Wound Management Innovat Cooperat Res Ctr, West End, Qld, Australia.
EM Kylie.Sandy-Hodgetts@curtin.edu.au
RI Zeps, Nikolajs/AAF-3186-2021; Sandy-Hodgetts, Kylie/A-7494-2019
OI Zeps, Nikolajs/0000-0002-6404-6839; Sandy-Hodgetts,
   Kylie/0000-0001-6848-2526
FU Wound Management Innovation CRC (WMICRC) Project Grant [3.30]
FX This study is funded by the Wound Management Innovation CRC (WMICRC)
   Project Grant 3.30 and devices are being donated to the study by product
   supplier Smith & Nephew.
CR [Anonymous], TXB SURG
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NR 28
TC 7
Z9 11
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2017
VL 26
IS 2
SU S
BP S23
EP S26
DI 10.12968/jowc.2017.26.Sup2.S23
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EM8HO
UT WOS:000395552300004
PM 28182535
DA 2026-07-24
ER

PT J
AU Ninan, N
   Thomas, S
   Grohens, Y
AF Ninan, Neethu
   Thomas, Sabu
   Grohens, Yves
TI Wound healing in urology
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Urology; Growth factors; Stem cells; siRNA; Laser tissue welding;
   Negative pressure wound therapy
ID MESENCHYMAL STEM-CELLS; HYPERBARIC-OXYGEN THERAPY; GROWTH-FACTORS;
   FIBRIN SEALANT; IN-VITRO; BOTULINUM-TOXIN; URETERAL INJURY; BLADDER;
   GENE; CYSTITIS
AB Wound healing is a dynamic and complex phenomenon of replacing devitalized tissues in the body. Urethral healing takes place in four phases namely inflammation, proliferation, maturation and remodelling, similar to dermal healing. However, the duration of each phase of wound healing in urology is extended for a longer period when compared to that of dermatology. An ideal wound dressing material removes exudate, creates a moist environment, offers protection from foreign substances and promotes tissue regeneration. A single wound dressing material shall not be sufficient to treat all kinds of wounds as each wound is distinct. This review includes the recent attempts to explore the hidden potential of growth factors, stem cells, siRNA, miRNA and drugs for promoting wound healing in urology. The review also discusses the different technologies used in hospitals to treat wounds in urology, which make use of innovative biomaterials synthesised in regenerative medicines like hydrogels, hydrocolloids, foams, films etc., incorporated with growth factors, drug molecules or nanopartides. These include surgical zippers, laser tissue welding, negative pressure wound therapy, and hyperbaric oxygen treatment (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ninan, Neethu; Grohens, Yves] Univ Bretagne Sud, Lab Ingn Mat Bretagne, F-56321 Lorient, France.
   [Ninan, Neethu; Thomas, Sabu] Mahatma Gandhi Univ, Ctr Nanosci & Nanotechnol, Kottayam 686560, Kerala, India.
C3 Mahatma Gandhi University, Kerala
RP Ninan, N (通讯作者)，Univ Bretagne Sud, Lab Ingn Mat Bretagne LIMatB, Ctr Rech Christiaan Huygens, Rue St Maude,BP 92116, F-56321 Lorient, France.
EM neethuninan85@yahoo.co.in
RI Ninan, Neethu/G-6281-2015; thomas, sabu/G-7310-2016
OI Ninan, Neethu/0000-0002-4469-5954; thomas, sabu/0000-0003-4726-5746
FU Brittany region; European Union (FEDER); French Ministry for research
FX We are thankful to Brittany region, The European Union (FEDER) and the
   French Ministry for research, for supporting this work.
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NR 105
TC 39
Z9 47
U1 1
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD MAR
PY 2015
VL 82-83
BP 93
EP 105
DI 10.1016/j.addr.2014.12.002
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CH0UF
UT WOS:000353737200012
PM 25500273
DA 2026-07-24
ER

PT J
AU Takahashi, H
   Takeda, S
   Tanaka, Y
   Shibata, R
   Ito, H
   Kurahashi, S
   Mitsuya, S
   Murakami, H
AF Takahashi, Hiroshi
   Takeda, Shinsuke
   Tanaka, Yoshihiro
   Shibata, Ryutaro
   Ito, Hiroki
   Kurahashi, Shingo
   Mitsuya, So
   Murakami, Hideki
TI Effectiveness of Specific Single-Use Incisional Negative Pressure Wound
   Therapy (PICO System) After Major Lower Extremity Amputation
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE lower extremity amputation; diabetes; wound management; arterial
   occlusive disease
AB Lower extremity amputation (LEA), particularly in patients with diabetes or peripheral vascular disease, often results in complications such as surgical site infections (SSIs) and wound dehiscence. This study examined whether utilizing the portable and user-friendly PICO system (Smith and Nephew Medical Ltd, Hull, UK) as incisional negative-pressure wound therapy can reduce post-LEA complications. This study was conducted at a Japanese tertiary medical center and involved a retrospective analysis of LEA cases (n = 32) between January 2021 and December 2022. The PICO dressing group (n = 16) was compared to the conventional dressing group (n = 16) for post-LEA wound management. The primary outcome was the incidence of postoperative wound complications, including SSI and wound dehiscence, within 15 days of LEA. Superficial/deep SSI and wound dehiscence occurred less frequently in the PICO dressing group than in the conventional dressing group (12.5% vs 43.8%; p = .054). There were no cases of deep SSIs in the PICO dressing group. Although this study has limitations owing to its retrospective design and small sample size, the results suggest the potential of the PICO system for improving outcomes in post-LEA wound management.
C1 [Takahashi, Hiroshi; Takeda, Shinsuke; Shibata, Ryutaro; Murakami, Hideki] Nagoya City Univ Hosp, Dept Orthopaed Surg, Nagoya, Japan.
   [Takahashi, Hiroshi] Khon Kaen Univ, Fac Med, Dept Orthoped, Khon Kaen, Thailand.
   [Tanaka, Yoshihiro] Shizuoka Grad Univ Publ Hlth, Sch Publ Hlth, Div Epidemiol, Shizuoka, Japan.
   [Shibata, Ryutaro; Ito, Hiroki; Kurahashi, Shingo; Mitsuya, So] Toyohashi Municipal Hosp, Trauma & Microsurg Ctr, Toyohashi, Japan.
   [Takeda, Shinsuke] Nagoya City Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 1 Kawasumi, Nagoya, Aichi 4678602, Japan.
C3 Nagoya City University; Khon Kaen University; Nagoya City University
RP Takeda, S (通讯作者)，Nagoya City Univ, Grad Sch Med Sci, Dept Orthopaed Surg, 1 Kawasumi, Nagoya, Aichi 4678602, Japan.
EM s7.takeda.jpn@gmail.com
RI Tanaka, Yoshihiro/ABH-3503-2021
OI Tanaka, Yoshihiro/0000-0002-6150-1592; Takeda,
   Shinsuke/0000-0002-9801-3963
CR Chang H, 2021, J VASC SURG, V73, P1041, DOI 10.1016/j.jvs.2020.07.061
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NR 14
TC 3
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2025
VL 24
IS 1
SI SI
BP 130
EP 134
DI 10.1177/15347346231221116
EA DEC 2023
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0X7J
UT WOS:001124410800001
PM 38092691
OA Bronze
DA 2026-07-24
ER

PT J
AU Saramago, P
   Gkekas, A
   Arundel, CE
   Chetter, IC
AF Saramago, Pedro
   Gkekas, Athanasios
   Arundel, Catherine E.
   Chetter, Ian C.
CA SWHSI-2 Trial Investigators
TI Negative pressure wound therapy for surgical wounds healing by secondary
   intention is not cost-effective
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID GROIN
AB Background Negative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim of this study was to evaluate the cost-effectiveness of NPWT for SWHSI, compared with standard dressings, from the perspective of the UK healthcare system. Methods An economic model was used to extrapolate the effectiveness results of a meta-analysis over a patient's lifetime and estimate the costs and outcomes (quality-adjusted life-years (QALYs)) of NPWT and standard dressings. The probability of NPWT being cost-effective was estimated, with extensive scenario analyses conducted to evaluate the robustness of results and the degree of uncertainty. Results On average, NPWT was associated with higher costs and marginally higher QALYs than standard dressings. The cost difference was mainly driven by the additional intervention costs associated with NPWT. The estimated probability of NPWT being cost-effective was <30%. There was considerable uncertainty in the findings, driven largely by uncertainty in the estimated pooled relative effect from the meta-analysis. Results were robust to different scenario analyses. Conclusion No evidence was found demonstrating that NPWT was a cost-effective alternative to standard dressings for SWHSI.
C1 [Saramago, Pedro] Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5D, England.
   [Gkekas, Athanasios; Arundel, Catherine E.] Univ York, York Trials Unit, York, England.
   [Chetter, Ian C.] Univ Hull, Fac Hlth Sci, Kingston Upon Hull, England.
   [Chetter, Ian C.] Hull York Med Sch, Kingston Upon Hull, England.
   [Chetter, Ian C.] Hull Univ Teaching Hosp NHS Trust, Kingston Upon Hull, England.
C3 University of York - UK; University of York - UK; University of Hull;
   University of Hull; University of York - UK
RP Saramago, P (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5D, England.
EM pedro.saramago@york.ac.uk
OI Gkekas, Athanasios/0000-0003-4357-9043; Arundel,
   Catherine/0000-0003-0512-4339; chetter, ian/0000-0002-2566-6859
FU National Institute for Health and Care Research; Hull University
   Teaching Hospitals NHS Trust
FX The authors would like to thank: the study participants who kindly
   agreed to take part in this study and the patient and public involvement
   representatives (D. Butler, D. Smith, and B. Alleyway), whose input was
   indispensable in developing study documentation; all participating site
   staff at each site involved in the study and staff who have supported
   the delivery of the SWHSI-2 study at the York Trials Unit, University of
   York (J. McCaffery, H. Rodrick, V. Exley, S. Rodgers, and C. Peck) and
   the Hull University Teaching Hospitals NHS Trust (C Acey and J. Long);
   and the Trial Steering Committee (Professor Richard Grieve (Chair), Mr
   Tristan Lane, Professor Dileep Lobo, Professor Judith Tanner, Margaret
   Ogden, and Peter Wheatstone) and the Data Monitoring Committee
   (Professor Peter Holt (Chair), Sarah Brown, and Professor Andrea Nelson)
   for their support, oversight, and input during the study.
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NR 31
TC 6
Z9 8
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD MAY
PY 2025
VL 112
IS 5
AR znaf077
DI 10.1093/bjs/znaf077
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 2GH5S
UT WOS:001481965000001
PM 40326752
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Nishimura, M
   Mizutani, K
   Yokota, N
   Goto, H
   Akeda, T
   Kitagawa, H
   Habe, K
   Hayashi, A
   Yamanaka, K
AF Nishimura, Mai
   Mizutani, Kento
   Yokota, Naho
   Goto, Hiroyuki
   Akeda, Tomoko
   Kitagawa, Hiroshi
   Habe, Koji
   Hayashi, Akinobu
   Yamanaka, Keiichi
TI Treatment Strategy for Pyoderma Gangrenosum: Skin Grafting with
   Immunosuppressive Drugs
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE pyoderma gangrenosum; dysregulation of inflammasome function; pathergy;
   negative pressure wound therapy; skin grafting; immunosuppressive drugs
ID FORMS
AB Pyoderma gangrenosum (PG) is a relatively rare neutrophilic dermatosis presenting as a rapidly progressive and painful skin ulcer characterized by undermined borders and peripheral erythema. Immunosuppressive therapy is the first-line treatment for PG; however, large ulcers often take months or years to heal. Surgical treatments, such as negative pressure wound therapy (NPWT) and skin grafting, are still controversial due to the risk of inducing the pathergy phenomenon and eliciting PG development by traumatic factors. Herein, we report on four cases of PG treated with skin grafting, with or without NPWT, under the control of immunosuppressive drugs at our institution. All cases adapted well, but one case showed recurrence at the periphery of the grafted area five months postoperatively. The current patients were treated with the following doses of oral prednisolone (PSL): PSL 10 mg daily, PSL 5 mg daily + adalimumab 40 mg/week, PSL 12 mg + 6 mg of tacrolimus daily, and PSL 20 mg daily during skin grafting. No severe complications, including infections, were observed. Surgical treatments, such as skin grafting with or without NPWT, may accelerate wound healing, shorten the administration of analgesics and long-term immunosuppressive therapy, and reduce the risk of infection.
C1 [Nishimura, Mai; Mizutani, Kento; Yokota, Naho; Goto, Hiroyuki; Akeda, Tomoko; Kitagawa, Hiroshi; Habe, Koji; Yamanaka, Keiichi] Mie Univ, Dept Dermatol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
   [Hayashi, Akinobu] Mie Univ, Dept Oncol Pathol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
C3 Mie University; Mie University
RP Yamanaka, K (通讯作者)，Mie Univ, Dept Dermatol, Grad Sch Med, 2-174 Edobashi, Tsu 5148507, Japan.
EM yamake@med.mie-u.ac.jp
RI ; Kitagawa, Hiroshi/CAJ-3523-2022
OI Mizutani, Kento/0000-0001-5171-4909; Nishimura, Mai/0000-0003-3016-5933
CR Almeida IR, 2021, WOUND REPAIR REGEN, V29, P486, DOI 10.1111/wrr.12910
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   Yamasaki K, 2020, J DERMATOL, V47, P1383, DOI 10.1111/1346-8138.15533
NR 17
TC 5
Z9 9
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2022
VL 11
IS 23
AR 6924
DI 10.3390/jcm11236924
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6X2KJ
UT WOS:000896248100001
PM 36498498
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mullins, RF
   Wilson, J
   Hassan, Z
   Homsombath, B
   Craft-Coffman, B
   Paglinawan, R
   Cregan, I
   Fagan, S
AF Mullins, Robert F.
   Wilson, Joan
   Hassan, Zaheed
   Homsombath, Bounthavy
   Craft-Coffman, Beretta
   Paglinawan, Rey
   Cregan, Inez
   Fagan, Shawn
TI The Role of Personal-use Negative Pressure Wound Therapy with Enhanced
   Functionality in Achieving Wound-related Treatment Goals: A Small
   Prospective Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE goals of care; granulation tissue; negative pressure wound therapy;
   patient satisfaction; wound healing
ID DIABETIC FOOT ULCERS; SINGLE-USE; IMPACT; COST
AB Background. NPWT is widely used to manage hard-to-heal wounds, and many different devices are available. Personal-use NPWT systems are becoming more popular, although current options have limited functionality. Purpose. The primary objective was to determine acceptable progress of wounds towards a predefined goal of therapy for a variety of open wounds being treated with a novel NPWT personal-use system with enhanced functionality. Methods. In this prospective, nonrandomized, interventional study, patients were treated with a personal-use NPWT system over 4 weeks, initially in a wound care clinic setting, and were discharged home with the device. Clinician satisfaction with the device was also evaluated. Results. Ten patients were evaluated. Acceptable progress towards all predetermined goals was reached for all patients; a median reduction in wound volume of 84.6% and improved granulation was achieved within the 4-week treatment period. No device-related deficiencies were reported. In general, clinicians were satisfied with the device's ease of use and mobility. Conclusion. Personal-use NPWT is easy to use, has positive effects on healing on a variety of wound types, and is well accepted by clinicians.
C1 [Mullins, Robert F.; Hassan, Zaheed; Homsombath, Bounthavy; Craft-Coffman, Beretta; Fagan, Shawn] Joseph M Still Burn Ctr Burn & Reconstruct Ctr Am, Adv Wound Clin, Augusta, GA USA.
   [Wilson, Joan] Joseph M Still Res Fdn Inc, Augusta, GA USA.
   [Paglinawan, Rey; Cregan, Inez] Medela AG, Baar, Switzerland.
RP Paglinawan, R (通讯作者)，Medela AG, Laettichstr 4b, CH-6340 Baar, Switzerland.
EM rey.paglinawan@medela.com
RI Mullins, Robert/I-6717-2013
FU Medela AG
FX The support of Medela AG as the sponsor for this project is gratefully
   acknowledged.
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Bechert K., 2020, Wounds, V32, pS1
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   Guest JF, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-045253
   Huang Q, 2019, J FOOT ANKLE SURG, V58, P954, DOI 10.1053/j.jfas.2018.12.020
   Kirsner R, 2019, WOUND REPAIR REGEN, V27, P519, DOI 10.1111/wrr.12727
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   Lee CK, 2018, S ADV WOUND CAR SPRI
   Lerman B, 2010, PLAST RECONSTR SURG, V126, P1253, DOI 10.1097/PRS.0b013e3181ea4559
   Lerman Bruce, 2010, J Diabetes Sci Technol, V4, P825
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   Payne Caroline, 2014, Eplasty, V14, pe20
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   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 20
TC 2
Z9 2
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2023
VL 35
IS 3
BP 53
EP 58
DI 10.25270/wnds/22019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MO5
UT WOS:001071608500010
PM 36917784
DA 2026-07-24
ER

PT J
AU Chen, LY
   Hou, JD
   Peng, CZ
AF Chen, Li-Yung
   Hou, Jin-De
   Peng, Chian-Ze
TI Bidirectional Irrigation System to Treat a Difficult Wound: A Case
   Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE difficult wound; negative-pressure wound therapy; therapeutic
   irrigation; healing rate; infection; case report
ID NEGATIVE-PRESSURE; METAANALYSIS; THERAPY; UPDATE; MANAGEMENT; INFECTION;
   BIOFILMS; DRAINAGE
AB Aims
   To date, there is no distinct principle determining whether to use irrigation under negative-pressure wound therapy (NPWT). We developed a new economical device to manage difficult wounds, employing 1 of 2 techniques depending on the wound condition.
   Methods
   This case series study was conducted in 12 patients with difficult wound, from 2017 to 2018. Four patients were treated with Type A bidirectional irrigation system (wound irrigation), while 8 patients were treated with Type B bidirectional irrigation system (wound irrigation combined with NPWT).
   Results
   In the Type A device group, inflammatory profiles in case I, case IV, and case VIII were not monitored due to the stability of their wound. The mean recovery period was 3.75 weeks (2-8 weeks), with decreases in 100% healing rate. In the Type B device group, we noted an average of 71% reduction in inflammatory profiles. All patients' infections were resolved or were healing, and 7 patients recovered satisfactorily. The recovery period ranged from 4 to 17 weeks, with a median value of 7 weeks.
   Conclusion
   Bidirectional irrigation system decreases secondary infections and complications, and increases the healing rate in patients with difficult wound.
C1 [Chen, Li-Yung] Kaohsiung Armed Forces Gen Hosp, Gangshan Branch, Kaohsiung, Taiwan.
   [Hou, Jin-De] Hualien Armed Forces Gen Hosp, Natl Def Med Ctr, Hualien, Taiwan.
   [Peng, Chian-Ze] Taipei Vet Gen Hosp, Taipei, Taiwan.
   [Peng, Chian-Ze] Taipei Vet Gen Hosp, Yuan Shan & Su Ao Branch, Yilan, Taiwan.
   [Peng, Chian-Ze] Triserv Gen Hosp, Natl Def Med Ctr, Taipei, Taiwan.
C3 National Defense Medical University; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; Tri-Service General Hospital; National
   Defense Medical University
RP Chen, LY (通讯作者)，Kaohsiung Armed Forces Gen Hosp, Dept Surg, Gangshan Branch, 1,Dayi 2nd Rd, Kaohsiung 820, Taiwan.
EM chenlijon.tw@yahoo.com.tw
OI Chen, Li-Yung/0000-0002-4311-3107
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
   Chen DY, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/6120173
   Chiu CC, 2011, BRIT J SURG, V98, P602, DOI 10.1002/bjs.7473
   Cowan T, 2012, J WOUND CARE, V21, P106, DOI 10.12968/jowc.2012.21.3.106
   Demirhan O, 2013, J THORAC DIS, V5, P265, DOI 10.3978/j.issn.2072-1439.2013.06.15
   Everett E, 2018, ANN NY ACAD SCI, V1411, P153, DOI 10.1111/nyas.13569
   Fluieraru S, 2013, J WOUND CARE, V22, P293, DOI 10.12968/jowc.2013.22.6.293
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   JACKSON FE, 1971, SURGERY, V70, P578
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   Liu CW, 2013, INDIAN J ORTHOP, V47, P93, DOI 10.4103/0019-5413.106925
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   Moore ZEH, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004983.pub3
   Oyama M, 2016, J CRANIOFAC SURG, V27, pE10, DOI 10.1097/SCS.0000000000002278
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   Strider DV, 2018, J VASC NURS, V36, P40, DOI 10.1016/j.jvn.2017.10.001
   Suissa D, 2011, PLAST RECONSTR SURG, V128, p498E, DOI 10.1097/PRS.0b013e31822b675c
   Vasudevan K, 2017, J NEUROSURG-PEDIATR, V20, P341, DOI 10.3171/2017.5.PEDS17101
   Willy C, 2017, UNFALLCHIRURG, V120, P549, DOI 10.1007/s00113-017-0375-5
   Wolcott RD, 2016, WOUND REPAIR REGEN, V24, P163, DOI 10.1111/wrr.12370
   Zhadan O, 2018, AESTHET SURG J, V38, P265, DOI 10.1093/asj/sjx171
NR 26
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 156
EP 162
AR 1534734620974551
DI 10.1177/1534734620974551
EA DEC 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000599541200001
PM 33295247
DA 2026-07-24
ER

PT J
AU Gonzalez, MG
   Barske, ME
   Kjellsson, KB
   Saboda, K
   Reed, HA
   Hill, MG
AF Gonzalez, Maritza G. G.
   Barske, M. Elisa
   Kjellsson, Kristine B. B.
   Saboda, Kathylynn
   Reed, Heather A. A.
   Hill, Meghan G. G.
TI Topical negative pressure wound therapy to prevent wound complications
   following caesarean delivery in high-risk obstetric patients: A
   randomised controlled trial
SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE caesarean incision; wound breakdown; wound infection; wound separation;
   wound vacuum
ID OBESE WOMEN
AB Background and AimsWe investigated whether the use of a prophylactic negative pressure wound therapy (NPWT) system in women undergoing caesarean would decrease wound complications in a high-risk population. Materials and MethodsA randomised controlled trial was performed. Women with risk factors for wound complications undergoing caesarean delivery were randomised to a standard dressing or NPWT placed over their caesarean wound. We standardised the closure of the subcutaneous fat and skin layers, both with Vicryl. Patients were followed for wound complications for up to 6 weeks after their caesareans. The incidence of wound complications was the primary outcome. The single-use NPWT system, PICO, was provided by Smith and Nephew for use in this trial. The trial was registered on , # NCT03082664. ResultsWe report here on 154 women randomised to either a standard dressing or to the NPWT. Wound complication rates were equivalent between groups, with 19.4 and 19.7% (P = 0.43) of women with follow-up information available experiencing wound complications. ConclusionWe found no difference in wound complications in women with risk factors treated with a prophylactic NPWT system or standard wound dressing at the time of caesarean birth.
C1 [Gonzalez, Maritza G. G.; Barske, M. Elisa; Kjellsson, Kristine B. B.; Reed, Heather A. A.; Hill, Meghan G. G.] Univ Arizona, Dept Obstet & Gynecol, Tucson, AZ USA.
   [Saboda, Kathylynn] Univ Arizona, Canc Ctr, Biostat & Bioinformat Shared Serv, Tucson, AZ USA.
   [Gonzalez, Maritza G. G.] Univ Chicago, Dept Obstet & Gynecol, 5841 S Maryland Ave MC250, Chicago, IL 60637 USA.
C3 University of Arizona; University of Arizona; University of Chicago
RP Gonzalez, MG (通讯作者)，Univ Chicago, Dept Obstet & Gynecol, 5841 S Maryland Ave MC250, Chicago, IL 60637 USA.
EM mggonzalez@bsd.uchicago.edu
FU Smith and Nephew Funding Source: Medline
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NR 14
TC 4
Z9 4
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8666
EI 1479-828X
J9 AUST NZ J OBSTET GYN
JI Aust. N. Z. J. Obstet. Gynaecol.
PD AUG
PY 2023
VL 63
IS 4
BP 516
EP 520
DI 10.1111/ajo.13675
EA MAY 2023
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FO8Q7
UT WOS:000979992800001
PM 37140175
DA 2026-07-24
ER

PT J
AU Stiehl, JB
AF Stiehl, James B.
TI Failure of Healing in Chronic Diabetic Wounds: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Editorial Material
DE debridement; diabetes; jet lavage irrigation; negative-pressure wound
   therapy; TIME paradigm; wound bed preparation
ID PULSATILE LAVAGE; BED PREPARATION; PULSED LAVAGE; IRRIGATION
AB Stalled healing in chronic wounds is a challenging problem for providers and remains multifactorial in etiology. Older adults with insulin-dependent diabetes are at very high risk. In this case report, two patients with large nonhealing wounds were considered for treatment with daily jet lavage irrigation in an attempt to remove the inflammatory products of their respective chronic wounds and eliminate the persisting biofilm bacteria. Several attempts were made to reduce treatments to two to three times per week, and negative-pressure wound therapy was initiated in both cases only to see the return of inflammation and necrosis of the wound bed. In both cases, the daily jet lavage irrigation was successful in creating a granulating wound bed that slowly healed over many months. One patient died with an open sacral pressure injury, and the other patient died 4 months after complete healing of a large heel pressure injury. The interesting observation is the necessity of daily high-intensity wound irrigation to correct the chronic infectious process. Diabetic chronic wounds in high-risk older adults are recalcitrant to standard wound treatments, and providers should consider daily jet lavage wound irrigation to deal with this problem.
C1 [Stiehl, James B.] St Marys Coll, Centralia, IL 62801 USA.
RP Stiehl, JB (通讯作者)，St Marys Coll, Centralia, IL 62801 USA.
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NR 27
TC 6
Z9 6
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2020
VL 33
IS 11
DI 10.1097/01.ASW.0000717896.88988.43
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA PB0SO
UT WOS:000596038300003
PM 33065686
OA hybrid
DA 2026-07-24
ER

PT J
AU Liguori, G
   Papa, G
   Boltri, M
   Stocco, C
   De Grazia, A
   Rizzo, M
   Pavan, N
   Ramella, V
   Trombetta, C
   Arnez, ZM
AF Liguori, Giovanni
   Papa, Giovanni
   Boltri, Matteo
   Stocco, Chiara
   De Grazia, Alessia
   Rizzo, Michele
   Pavan, Nicola
   Ramella, Vittorio
   Trombetta, Carlo
   Arnez, Zoran Marij
TI Reconstruction of penile skin loss using a combined therapy of negative
   pressure wound therapy, dermal regeneration template, and
   split-thickness skin graft application
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID MANAGEMENT; SHAFT
AB This study evaluates the use of acellular dermal matrix (ADM) in conjunction with negative pressure wound therapy (NPWT) and delayed split-thickness skin graft (STSG) application as an alternative to free tissue transfer for defect coverage of the penile shaft. Five patients with genital lymphedema and one with penile skin deficiency underwent penile shaft reconstruction with a two-stage surgical procedure. The first procedure aimed to the correction of skin defect and to neodermis regeneration through the use of an ADM (Integra (R), Integra Lifesciences Corp., Plainsboro, NJ, USA) and NPWT. The second procedure 3 weeks later aimed to the covering of the skin defect with an unmeshed STSG. Both the Integra and skin graft showed completely taking at 7 days postop. No major complications occurred. At 6 months grafts gained sufficient elasticity to allow the sliding of the epidermis over the dermal layer, similarly the physiological penile shaft skin. Our results suggest that combined therapy might be an alternative to free tissue transfer for defect coverage of the penile shaft, leading to a good esthetic result, an optimal shaft coverage and providing adequate extensibility during erections. For best results we advise that in these cases urologists should collaborate with plastic surgeons.
C1 [Liguori, Giovanni; Boltri, Matteo; Rizzo, Michele; Pavan, Nicola; Trombetta, Carlo] Univ Trieste, Dept Urol, Trieste, Italy.
   [Papa, Giovanni; Stocco, Chiara; De Grazia, Alessia; Ramella, Vittorio; Arnez, Zoran Marij] Univ Trieste, Dept Plast Surg, Trieste, Italy.
C3 University of Trieste; University of Trieste
RP Liguori, G (通讯作者)，Univ Trieste, Dept Urol, Trieste, Italy.
EM gioliguori33@gmail.com
RI Pavan, Nicola/V-9850-2019; Boltri, Matteo/AHD-7996-2022; liguori,
   giovanni/U-8792-2019; Arnez, Zoran/AAA-2112-2019; Ramella,
   Vittorio/AAU-3267-2021
OI Boltri, Matteo/0000-0002-5177-6445; RIZZO, MICHELE/0000-0001-5074-2043;
   liguori, giovanni/0000-0003-2431-5296; 
CR Alei G, 2012, J SEX MED, V9, P1945, DOI 10.1111/j.1743-6109.2012.02744.x
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NR 25
TC 4
Z9 4
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD DEC
PY 2021
VL 33
IS 8
BP 854
EP 859
DI 10.1038/s41443-020-00343-1
EA AUG 2020
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YP9AK
UT WOS:000560450200001
PM 32801347
DA 2026-07-24
ER

PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI How influential is the stiffness of the foam dressing on soft tissue
   loads in negative pressure wound therapy?
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Wound care; Tissue repair and regeneration; Pressure ulcer; Diabetic
   foot ulcer; Biomechanical model
AB Negative pressure wound therapy (NPWT) is an established adjunctive modality for treatment of both acute and chronic wounds. However, little is known about the optimal settings and combination of treatment parameters and importantly, how these translate to target tissue strains and stresses that would result the fastest healing and buildup of good-quality tissues. Here we have used a three-dimensional open wound computational (finite element) model that contains viscoelastic skin, adipose and skeletal muscle tissue components for determining the states of tissue strains and stresses in and around the wound when subjected to NPWT with foam dressings of varying stiffnesses. We found that the skin strain state is considerably more sensitive to the pressure level than to the stiffness of the foam dressing within a 8.25 to 99 kPa range which covers the current industry standard. Accordingly, pen-wound skin strains and stresses which stimulate cell proliferation/migration and angiogenesis and thereby, healing of the wound, can be more effectively controlled by adjusting the pressure level than by varying the stiffness of the foam dressing. (C) 2021 IPEM. Published by Elsevier Ltd. All rights reserved.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
FU European Union's Horizon 2020 research and innovation programme under
   the Marie Sklodowska-Curie grant [811965]; Israeli Ministry of Science &
   Technology (Medical Devices Program) [3-17421]
FX This project has received funding from the European Union's Horizon 2020
   research and innovation programme under the Marie Sklodowska-Curie grant
   agreement No. 811965 (STINTS). This work was also partially supported by
   the Israeli Ministry of Science & Technology (Medical Devices Program
   Grant no. 3-17421, awarded to Professor Amit Gefen in 2020).
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NR 43
TC 8
Z9 9
U1 0
U2 15
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD MAR
PY 2021
VL 89
BP 33
EP 41
DI 10.1016/j.medengphy.2021.02.001
EA FEB 2021
PG 9
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA QI7OJ
UT WOS:000619172500006
PM 33608123
DA 2026-07-24
ER

PT J
AU Yane, Y
   Hida, J
   Makutani, Y
   Ushijima, H
   Yoshioka, Y
   Iwamoto, M
   Wada, T
   Daito, K
   Tokoro, T
   Ueda, K
   Kawamura, J
AF Yane, Yoshinori
   Hida, Jin-ichi
   Makutani, Yusuke
   Ushijima, Hokuto
   Yoshioka, Yasumasa
   Iwamoto, Masayoshi
   Wada, Toshiaki
   Daito, Koji
   Tokoro, Tadao
   Ueda, Kazuki
   Kawamura, Junichiro
TI The technique for less infectious and earlier healing of stoma closure
   wound: negative pressure wound therapy with instillation and dwelling
   followed by primary closure
SO BMC SURGERY
LA English
DT Article
DE Stoma closure; Surgical site infection; SSI; NPWTi-d; Delayed primary
   closure; V; A; C; VERAFLO Therapy
AB BackgroundTemporary stomas have been widely used to avoid the risk of complications such as anastomotic leakage after colorectal resection. Stoma closure is relatively easy; however, postoperative surgical site infection (SSI) may be a problem. Various methods have been used to reduce the incidence of SSI. We aimed to evaluate a new technique for stoma wound closure.MethodsWe enrolled patients who underwent stoma closure at our hospital between September 2019 and May 2020. We selected patients who lived far from our hospital and had difficulty visiting the hospital regularly and who agreed to undergo this surgical technique. We used negative pressure wound therapy with instillation and dwelling (NPWTi-d) and delayed primary closure for these patients.ResultsFour patients underwent NPWTi-d and delayed primary closure without the occurrence of SSI. The median postoperative hospital stay was 9 days (range: 7-14 days), and the median number of days to confirmation of epithelialization was 11.5 days (range: 10-16 days).ConclusionThe combined use of NPWTi-d and delayed primary closure for the stoma wound was very effective. This method may be a valuable new technique for wound management after stoma closure.
C1 [Yane, Yoshinori; Makutani, Yusuke; Ushijima, Hokuto; Yoshioka, Yasumasa; Iwamoto, Masayoshi; Wada, Toshiaki; Daito, Koji; Tokoro, Tadao; Ueda, Kazuki; Kawamura, Junichiro] Kindai Univ, Fac Med, Dept Surg, Osaka, Japan.
   [Hida, Jin-ichi] Kindai Univ, Dept Gastroenterol Surg, Nara Hosp, Nara, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University)
RP Yane, Y (通讯作者)，Kindai Univ, Fac Med, Dept Surg, Osaka, Japan.
EM yaneyoshinori0127@med.kindai.ac.jp
RI Ueda, Kazuki/AAB-6618-2022; Kawamura, Junichiro/H-9205-2019; 幕谷,
   悠介/IAP-9683-2023
OI Kawamura, Junichiro/0000-0001-5404-5317; 
FU Grants-in-Aid for Scientific Research [21H04958] Funding Source: KAKEN
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NR 21
TC 6
Z9 8
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD MAR 22
PY 2021
VL 21
IS 1
AR 157
DI 10.1186/s12893-021-01109-2
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RF3WO
UT WOS:000634772000002
PM 33752660
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ciudad, P
   Vargas, MI
   Castillo-Soto, A
   Sanchez, JR
   Manrique, OJ
   Bustos, SS
   Forte, AJ
   Huayllani, MT
   Soto, Z
   Grández-Urbina, JA
AF Ciudad, Pedro
   Vargas, Maria I.
   Castillo-Soto, Ana
   Sanchez, Jefferson R.
   Manrique, Oscar J.
   Bustos, Samyd S.
   Forte, Antonio J.
   Huayllani, Maria T.
   Soto, Zoila
   Antonio Grandez-Urbina, J.
TI Microvascular free-flap reconstruction in acute hard-to-heal wounds
SO JOURNAL OF WOUND CARE
LA Spanish
DT Article
DE negative pressure wound therapy; hard-to-heal wounds; reconstruction;
   microvascular free flap
ID LOWER-LIMB INJURY; MICROSURGICAL RECONSTRUCTION; THERAPY; TRAUMA; LADDER
AB Objective: Present different flap alternatives when performing microvascular free-flap reconstruction in acute hard-to-heal wounds. Method: A retrospective review of patients whose acute hard-to-heal wounds were treated with microvascular free-flap reconstruction. Data on demographics, wound aetiology, diagnostic, previous treatment, free-flap type, free-flap size, complications and follow up were analysed. Results: A total of 20 patients received microvascular free-flap reconstruction. The median age was 39.5 years. Twenty free-flap reconstructions were performed. These included: 3 cross-leg free flap, 1 cross-leg vascular cable bridge flap, 2 fibula osteocutaneous flap, 6 anterolateral thigh (ALT) flap, 3 thoracodorsal artery perforator (TDAP) flap, 3 fasciomyocutaneous flap, and 2 femoral artery fasciocutaneous flap. A patient required microvascular anastomosis due to hematoma; the rest did not present complications during their postoperative. Previous treatment included negative pressure wound therapy (12 patients) and surgical debridement with silver hydrogel dressings (8 patients). Conclusion: Hard-to-heal wounds can be unresponsive to traditional wound healing practices or local flaps. They often require free-flap reconstruction, using tissues similar to those compromised. Microvascular techniques can be an effective alternative.
C1 [Ciudad, Pedro; Vargas, Maria I.] Hosp Nacl Arzobispo Loayza, Dept Cirugia Plast Reconstruct & Quemaduras, Lima, Peru.
   [Ciudad, Pedro] China Med Univ Hosp, Div Cirujia Plast, Taichung, Taiwan.
   [Castillo-Soto, Ana; Sanchez, Jefferson R.] Univ Peruana Ciencias Aplicadas, Fac Med, Lima, Peru.
   [Manrique, Oscar J.; Bustos, Samyd S.] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN USA.
   [Forte, Antonio J.; Huayllani, Maria T.] Mayo Clin, Div Cirugia Plast & Reconstruct, Jacksonville, FL 32224 USA.
   [Soto, Zoila] Renacer Clin, Lima, Peru.
   [Antonio Grandez-Urbina, J.] Univ Continental, Lima, Peru.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; Universidad Peruana de Ciencias Aplicadas (UPC); Mayo Clinic;
   Mayo Clinic; Universidad Continental
RP Ciudad, P (通讯作者)，Hosp Nacl Arzobispo Loayza, Dept Cirugia Plast Reconstruct & Quemaduras, Lima, Peru.; Ciudad, P (通讯作者)，China Med Univ Hosp, Div Cirujia Plast, Taichung, Taiwan.
EM pciudad@hotmail.com
RI Bustos, Samyd/AAW-2029-2020; Forte, Antonio Jorge/I-2970-2019;
   Grandez-Urbina, J. Antonio/PNF-5974-2026
OI Bustos, Samyd/0000-0003-2907-1067; Forte, Antonio
   Jorge/0000-0003-2004-7538; 
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NR 31
TC 2
Z9 2
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2020
VL 29
IS 10
SU 1
BP 27
EP 34
DI 10.12968/jowc.2020.29.LatAm_sup_2.27
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OF0AU
UT WOS:000580883100003
PM 33054617
DA 2026-07-24
ER

PT J
AU Kiliç, E
   Ugur, M
   Yetim, I
   Temiz, M
AF Kilic, Erol
   Ugur, Mustafa
   Yetim, Ibrahim
   Temiz, Muhyittin
TI Effects of temporary abdominal closure methods on mortality and
   morbidity in patients with open abdomen
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Baker method; Bogota bag; Non-vacuum assisted closure method (NVACM);
   open abdomen; temporary abdomen closure; acuum-Assisted Closure Method
   (VACM)
ID MEDIATED FASCIAL TRACTION; ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME;
   MANAGEMENT; SEPSIS; TRAUMA
AB BACKGROUND: Open abdomen (OA) in which the abdomen is closed with temporary abdominal closure methods is the most effective in patients who develop severe abdominal sepsis or abdominal compartment syndrome. Major techniques used are Vacuum-Assisted Closure Method (VACM) and non-vacuum assisted closure method (NVACM). In the present study, the effects of different abdominal closure methods on morbidity and mortality were evaluated.
   METHODS: In the study, the temporary abdominal closure methods of the patients with OA during 2013-2016 were studied retrospectively. OA etiopathologies, mortality prediction scores, final abdominal closure periods and methods, hospitalization periods, complications (enteroatmospheric fistula, mesh infection, and incisional hernia), and mortality rates of patients who underwent VACM and NVACM were determined and compared.
   RESULTS: The present study included 123 patients who underwent VACM (n=65) and NVACM (n=58). There was no difference between the groups in terms of age, gender, and etiopathogenesis (p>0.05). The mean APACHE 4 and Multiple Organ Dysfunction Score (MODS) scores in the VACM/NVACM groups in treatment period were 47/63 and 11/14, respectively (p<0.05). The mean intensive care and hospitalization periods in the VACM/NVACM groups were 11/16 (days) and 22/28 (days), respectively (p<0.05). The collection and abscess development rates in the VACM and NVACM groups were 46.2% and 77.6%, respectively (p<0.05). The rate of enteroatmospheric fistula (EAF) development in the VACM and NVACM groups were 15.4% and 56.9%, respectively (p<0.05). The mean abdominal closure times in the VACM and NVACM groups were 13 and 17 days, respectively (p<0.05). Mortality rate in the VACM and NVACM groups were 18% (n=18) and 55% (n=32), respectively (p<0.05).
   CONCLUSION: In patients with OA, the temporary abdominal closure technique VACM has lower complication and mortality rates and shorter hospitalization period than other methods. Therefore, it is an effective and safe method for the treatment of OA.
C1 [Kilic, Erol; Ugur, Mustafa; Yetim, Ibrahim; Temiz, Muhyittin] Mustafa Kemal Univ, Dept Gen Surg, Fac Med, Antakya, Turkey.
C3 Hatay Mustafa Kemal University
RP Kiliç, E (通讯作者)，Mustafa Kemal Univ, Dept Gen Surg, Fac Med, Antakya, Turkey.
EM ekkilic55@gmail.com
RI ; Ugur, Mustafa/JAO-0517-2023
OI Yetim, İbrahim/0009-0001-7683-1260; Ugur, Mustafa/0000-0002-5922-2367
CR [Anonymous], 2007, OPUS 12 SCI
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Balogh Z, 2003, J TRAUMA, V54, P848, DOI 10.1097/01.TA.0000070166.29649.F3
   Borráez Oswaldo Alfonso, 2008, rev. colomb. cir., V23, P204
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   Nathens AB, 1997, CAN J SURG, V40, P254
   Nicholas JM, 2003, J TRAUMA, V55, P1095, DOI 10.1097/01.TA.0000101067.52018.42
   Perez D, 2007, J AM COLL SURGEONS, V205, P586, DOI 10.1016/j.jamcollsurg.2007.05.015
   Petersson U, 2007, WORLD J SURG, V31, P2133, DOI 10.1007/s00268-007-9222-0
   PLAUDIS H, 2012, ANN INTENSIVE CAR S1, V2
   Refinetti RA, 2010, ABCD-ARQ BRAS CIR DI, V23, P122, DOI 10.1590/S0102-67202010000200013
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
   Ribeiro MAF, 2016, WORLD J GASTRO SURG, V8, P590, DOI 10.4240/wjgs.v8.i8.590
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
   Tieu BH, 2008, J TRAUMA, V65, P865, DOI 10.1097/TA.0b013e31818481f1
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   Willms A, 2015, LANGENBECK ARCH SURG, V400, P91, DOI 10.1007/s00423-014-1240-4
NR 18
TC 1
Z9 6
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JUL
PY 2018
VL 24
IS 4
BP 321
EP 326
DI 10.5505/tjtes.2017.95038
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GN8MU
UT WOS:000439418700007
PM 30028489
OA Bronze
DA 2026-07-24
ER

PT J
AU Ugurlar, M
   Sönmez, MM
   Armagan, R
   Eren, OT
AF Ugurlar, Meric
   Sonmez, Mesut Mehmet
   Armagan, Raffi
   Eren, Osman Tugrul
TI Comparison of two different vacuum-assisted closure (VAC) treatments of
   multiple chronic diabetic foot wounds in the same extremity
SO FOOT AND ANKLE SURGERY
LA English
DT Article
DE Y-connector; Bridge-VAC; Diabetic foot; Chronic wound
ID RANDOMIZED CONTROLLED-TRIAL; LEG ULCERS; THERAPY; FOUNDATION;
   MANAGEMENT; AMPUTATION; DRESSINGS; INJURIES; STATE
AB Background: The aim of the present study is to compare the clinical efficacy and safety of two different vacuum-assisted closure (VAC) applications in one center between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds.
   Methods: The study was a randomized-controlled, prospective investigation between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds at single extremity. There were 10 patients in the first group receiving VAC treatment by means of Y-connector and 11 patients in the second group receiving bridge-VAC treatment.
   Results: There were no significant difference in Revised Foot Function Index scores and total treatment costs between the both groups. The cost of the VAC dressing supplies in one session of the dressings was lower in the bridge-VAC group.
   Conclusions: In conclusion, although bridge-VAC treatment seems to be an alternative method to the VAC treatment by means of Y-connector, we found no superiority of one over the other VAC application for chronic diabetic foot wounds. (C) 2016 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
C1 [Ugurlar, Meric; Sonmez, Mesut Mehmet; Armagan, Raffi; Eren, Osman Tugrul] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Orthopaed & Traumatol, Istanbul, Turkey.
C3 Istanbul Sisli Hamidiye Etfal Training & Research Hospital
RP Ugurlar, M (通讯作者)，Sisli Hamidiye Etfal Egitim & Arastirma Hastanesi, TR-34371 Istanbul, Turkey.
EM mugurlar@yahoo.com; mdmesutsonmez@yahoo.com; raffiarmagan@gmail.com;
   tugruleren@hotmail.com
RI Uğurlar, Meriç/M-1784-2016; eren, osman/HIK-2394-2022; Armagan,
   Raffi/GPS-4921-2022
OI Uğurlar, Meriç/0000-0003-0145-6272; 
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NR 26
TC 5
Z9 8
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1268-7731
EI 1460-9584
J9 FOOT ANKLE SURG
JI Foot Ankle Surg.
PD SEP
PY 2017
VL 23
IS 3
BP 173
EP 178
DI 10.1016/j.fas.2016.05.314
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FH1UA
UT WOS:000410923900009
PM 28865586
DA 2026-07-24
ER

PT J
AU Morykwas, MJ
   Simpson, J
   Punger, K
   Argenta, A
   Kremers, L
   Argenta, J
AF Morykwas, Michael J.
   Simpson, Jordan
   Punger, Kally
   Argenta, Anne
   Kremers, Lieveke
   Argenta, Joseph
TI Vacuum-assisted closure: State of basic research and physiologic
   foundation
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID SUBATMOSPHERIC PRESSURE; TISSUE EXPANSION; WOUND THERAPY; SWINE MODEL;
   SKIN; STRETCH; GROWTH; BURNS
AB A tremendous amount of research has been conducted in recent years investigating the mechanisms of action by which the application of subatmospheric pressure to wounds increases the rate of healing. Similarly, numerous studies have also been conducted examining the physiologic response of wounds to the applied subatmospheric pressure. However, many more need to be conducted. A series of basic studies examining the use of subatmospheric pressure to treat wounds is presented, including the original studies upon which the vacuum-assisted closure device was based (on blood flow, granulation tissue formation, bacterial clearance, and survival of random-pattern pedicle flaps). Subsequent studies analyzing removed fluids, envenomation/extravasation, burns, grafts, and in vitro tissue culture studies are also reviewed. Two broad mechanisms of action are proposed: removal of fluid and mechanical deformation. Fluid removal both decreases edemathus decreasing interstitial pressure and shortening distances of diffusion- and removes soluble factors that may affect the healing process (both positively and negatively). The relationship of mechanical deformation to increased growth is well known to plastic surgeons, as it is the basis of tissue expansion. While much has been done, a great deal more needs to be done to elucidate the mechanisms of action responsible for the dramatic response seen clinically.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
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NR 38
TC 311
Z9 374
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2006
VL 117
IS 7
SU S
BP 121S
EP 126S
DI 10.1097/01.prs.0000225450.12593.12
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 056UA
UT WOS:000238549400011
PM 16799379
DA 2026-07-24
ER

PT J
AU Lei, FR
   Shen, XF
   Zhang, C
   Li, XQ
   Zhuang, H
   Sang, HF
AF Lei, Feng-Rui
   Shen, Xiao-Fei
   Zhang, Chuang
   Li, Xin-Qing
   Zhuang, Hao
   Sang, Hong-Fei
TI Clinical efficacy of endovascular revascularization combined with
   vacuum-assisted closure for the treatment of diabetic foot
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Diabetic foot; Revascularization; Vacuum-assisted closure; Balloon
   angioplasty; Wound repair
ID TISSUE LOSS; ANGIOPLASTY; ISCHEMIA; BYPASS; IMPACT
AB BACKGROUND The diabetic foot is a common cause of disability and death, and comorbid foot infections usually lead to prolonged hospitalization, high healthcare costs, and a significant increase in amputation rates. And most diabetic foot trauma is complicated by lower extremity arteriopathy, which becomes an independent risk factor for major amputation in diabetic foot patients. AIM To establish the efficacy and safety of endovascular revascularization (ER) combined with vacuum-assisted closure (VAC) for the treatment of diabetic foot. METHODS Clinical data were collected from 40 patients with diabetic foot admitted to the Second Affiliated Hospital of Soochow University from April 2018 to April 2022. Diabetic foot lesions were graded according to Wagner's classification, and blood flow to the lower extremity was evaluated using the ankle-brachial index test and computerized tomography angiography of the lower extremity arteries. Continuous subcutaneous insulin infusion pumps were used to achieve glycemic control. Lower limb revascularization was facilitated by percutaneous tran-sluminal balloon angioplasty (BA) or stenting. Wounds were cleaned by nibbling debridement. Wound granulation tissue growth was induced by VAC, and wound repair was performed by skin grafting or skin flap transplantation. RESULTS Of the 35 cases treated with lower limb revascularization, 34 were successful with a revascularization success rate of 97%. Of these, 6 cases underwent stenting after BA of the superficial femoral artery, and 1 received popliteal artery stent implantation. In the 25 cases treated with infrapopliteal artery revascularization, 39 arteries were reconstructed, 7 of which were treated by drug-coated BA and the remaining 32 with plain old BA. VAC was performed in 32 wounds. Twenty-four cases of skin grafting and 2 cases of skin flap transplantation were performed. Two patients underwent major amputations, whereas 17 had minor amputations, accounting for a success limb salvage rate of 95%. CONCLUSION ER in combination with VAC is a safe and effective treatment for diabetic foot that can significantly improve limb salvage rates. The use of VAC after ER simplifies and facilitates wound repair.
C1 [Lei, Feng-Rui; Shen, Xiao-Fei; Zhang, Chuang; Li, Xin-Qing; Zhuang, Hao; Sang, Hong-Fei] Soochow Univ, Affiliated Hosp 2, Dept Vasc Surg, 1055 Sanxiang Rd, Suzhou 215004, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Sang, HF (通讯作者)，Soochow Univ, Affiliated Hosp 2, Dept Vasc Surg, 1055 Sanxiang Rd, Suzhou 215004, Jiangsu, Peoples R China.
EM sanghongfei@163.com
RI shen, xiaofei/LRT-1082-2024; Li, Xinqing/QJW-7508-2026
CR Alexandrescu VA, 2020, J ENDOVASC THER, V27, P20, DOI 10.1177/1526602819885131
   Bradbury AW, 2005, LANCET, V366, P1925, DOI 10.1016/S0140-6736(05)67707-5
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   Faglia E, 2005, EUR J VASC ENDOVASC, V29, P620, DOI 10.1016/j.ejvs.2005.02.035
   Farber A, 2022, NEW ENGL J MED, V387, P2305, DOI 10.1056/NEJMoa2207899
   Jung HW, 2019, EUR J VASC ENDOVASC, V58, P854, DOI 10.1016/j.ejvs.2019.07.034
   Nakama Tatsuya, 2017, JACC Cardiovasc Interv, V10, P79, DOI [10.1016/j.jcin.2016.10.025, 10.1016/j.jcin.2016.10.025]
   OAKLEY W, 1955, Trans Med Soc Lond, V71, P90
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   Wang Ai-hong, 2012, Zhonghua Yi Xue Za Zhi, V92, P219
NR 12
TC 4
Z9 4
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUL 15
PY 2024
VL 15
IS 7
DI 10.4239/wjd.v15.i7.1499
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA A4B1H
UT WOS:001281989200010
PM 39099828
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shi, H
   Zhu, L
   Jiang, ZL
   Huang, ZH
   Wu, XT
AF Shi, Hang
   Zhu, Lei
   Jiang, Zan-Li
   Huang, Zhi-Hao
   Wu, Xiao-Tao
TI The use of incisional vacuum-assisted closure system following one-stage
   incision suture combined with continuous irrigation to treat early deep
   surgical site infection after posterior lumbar fusion with
   instrumentation
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; One-stage incision suture; Continuous
   irrigation; Early deep surgical site infection; Posterior lumbar fusion
   with instrumentation
ID PRESSURE WOUND THERAPY; SPINAL INSTRUMENTATION
AB Background Previous reports concerning deep surgical site infection (SSI) after posterior spinal instrumentation treated with vacuum-assisted closure (VAC) system indicated that most patients must suffer from a delayed incision suture. To date, there are no published reports about the application of incisional VAC following a one-stage incision suture in the treatment of spinal infections. The purpose of this study was to evaluate the feasibility and efficacy of using an incisional VAC system following a one-stage incision suture combined with continuous irrigation to treat early deep SSI after posterior lumbar fusion with instrumentation. Methods Twenty-one patients who were identified as early deep SSI after posterior lumbar fusion with instrumentation were treated by incisional VAC following a one-stage incision suture combined with continuous irrigation at our spine surgery center between January 2014 and March 2020. Detailed data from medical records were collected and analyzed, including age, gender, primary diagnosis, original operation, number of VAC dressing changes, duration of continuous irrigation, hospital stay, risk factors for infection, bacteria type, and laboratory data. Clinical efficacy was assessed using the pre- and postoperative visual analog scale (VAS) for back pain and Kirkaldy-Willis functional criteria by regular follow-up. Results All the patients were cured and retained implants with an average of 1.9 times of VAC dressing replacement, and an average of 10.2 days of continuous irrigation. There were significant differences between pre-operation and post-operation in ESR, CRP, and VAS score of back pain, respectively (P < 0.05). The satisfactory rate was 90.5% according to Kirkaldy-Willis functional criteria. One patient developed a back skin rash with itching around the wound because of long-time contact with the VAC dressing. There was no recurrent infection or other complications during follow-up. Conclusions Our preliminary results support that the treatment protocol is feasible and effective to treat early deep SSI following posterior lumbar fusion with instrumentation.
C1 [Shi, Hang; Zhu, Lei; Jiang, Zan-Li; Huang, Zhi-Hao; Wu, Xiao-Tao] Southeast Univ, Sch Med, Zhongda Hosp, Dept Spine Surg, Nanjing 210009, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Wu, XT (通讯作者)，Southeast Univ, Sch Med, Zhongda Hosp, Dept Spine Surg, Nanjing 210009, Jiangsu, Peoples R China.
EM wuxiaotaospine@seu.edu.cn
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 26
TC 9
Z9 10
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JUL 9
PY 2021
VL 16
IS 1
AR 445
DI 10.1186/s13018-021-02588-y
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA TI2XM
UT WOS:000672658200003
PM 34243798
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chou, PR
   Wu, SH
   Hsieh, MC
   Huang, SH
AF Chou, Ping-Ruey
   Wu, Sheng-Hua
   Hsieh, Meng-Chien
   Huang, Shu-Hung
TI Retrospective Study on the Clinical Superiority of the Vacuum-Assisted
   Closure System with a Silicon-Based Dressing over the Conventional
   Tie-over Bolster Technique in Skin Graft Fixation
SO MEDICINA-LITHUANIA
LA English
DT Article
DE VAC; silicon-based dressing; pain; skin graft
ID PRESSURE WOUND THERAPY; PAIN INTENSITY; CONTACT LAYER; DEVICE; MEPITEL
AB Background and Objectives: The tie-over bolster technique has been conventionally used for skin graft fixation; however, long operative times and postoperative pain are the main disadvantages of this method. In this study, we introduce a new method using vacuum-assisted closure (VAC) with a silicon-based dressing as an alternative for skin graft fixation. This retrospective study aimed to evaluate the clinical effect of the VAC plus silicon-based dressing method and the conventional tie-over bolster technique for skin graft fixation in terms of pain, operative time, and skin graft take rate. Materials and Methods: Sixty patients who underwent skin graft surgery performed by a single surgeon from January 2017 to October 2018 were included in this clinical study. They were divided into two groups based on the type of treatment: tie-over bolster technique and vacuum-assisted closure (VAC), or silicon-based dressing groups. The operative times were recorded twice (during suturing or stapling of the graft and during removal of the dressing) in the two groups; similarly, pain was assessed using a numeric rating scale (NRS) after surgery and during dressing removal. Skin graft take rate was evaluated two weeks after dressing removal. Results: Twenty-six patients who met the eligibility criteria were enrolled into the study and assigned to one of the two groups (n = 13 each). No significant differences in age, gender, and graft area were noted between the two groups of patients. The VAC plus silicon-based dressing group demonstrated higher skin graft take rates (p < 0.05), shorter operation times (p < 0.05), and lower levels of pain (postoperative pain and pain during dressing removal) compared with the tie-over bolster technique group (p < 0.05). Conclusions: These findings indicate that VAC with silicon-based dressing can be used for skin graft fixation due to its superior properties when compared with the conventional method, and can improve the quality of life of patients undergoing skin graft fixation.
C1 [Chou, Ping-Ruey] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Med Univ Hosp, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Wu, Sheng-Hua] Kaohsiung Municipal Tatung Hosp, Dept Anesthesiol, Kaohsiung 807, Taiwan.
   [Hsieh, Meng-Chien; Huang, Shu-Hung] Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung 807, Taiwan.
   [Huang, Shu-Hung] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan.
   [Huang, Shu-Hung] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University
RP Huang, SH (通讯作者)，Kaohsiung Med Univ Hosp, Dept Surg, Div Plast Surg, Kaohsiung 807, Taiwan.; Huang, SH (通讯作者)，Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan.; Huang, SH (通讯作者)，Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807, Taiwan.
EM u105025047@gap.kmu.edu.tw; elsawu2@gmail.com; williehsieh@hotmail.com;
   huangsh63@gmail.com
RI Huang, Shu-Hung/AAA-3445-2021
OI Huang, Shu-Hung/0000-0002-2903-1703; Chou, Ping-Ruey/0000-0003-0960-8277
FU Ministry of Science and Technology of Taiwan [107-2314-B-037-063-MY2];
   Ministry of Health and Welfare [MOHW107-TDU-B-212-123006]; Kaohsiung
   Medical University Research Center [KMU-TC108A02]; Childhood Burn
   Foundation of the Republic of China
FX We acknowledge the grant support for this study provided by the Ministry
   of Science and Technology of Taiwan (107-2314-B-037-063-MY2), Ministry
   of Health and Welfare (MOHW107-TDU-B-212-123006), Kaohsiung Medical
   University Research Center (KMU-TC108A02), and Childhood Burn Foundation
   of the Republic of China.
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NR 36
TC 11
Z9 13
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD DEC
PY 2019
VL 55
IS 12
AR 781
DI 10.3390/medicina55120781
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KA3ZW
UT WOS:000505737800022
PM 31842472
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yuan, W
   Liu, X
   Zhou, XS
   Pei, L
   Zhu, Y
AF Yuan, Wei
   Liu, Xuan
   Zhou, Xiaoshu
   Pei, Lei
   Zhu, Yue
TI Management of Early Deep Wound Infection After Thoracolumbar
   Instrumentation Continuous Irrigation Suction System versus
   Vacuum-Assisted Closure System
SO SPINE
LA English
DT Article
DE continuous irrigation suction system; deep wound infection; early;
   outcomes; thoracolumbar instrumentation; vacuum-assisted closure system
ID SURGICAL SITE INFECTIONS; POSTERIOR SPINAL-FUSION; RISK-FACTORS;
   POSTOPERATIVE INFECTIONS; THERAPY; SURGERY; PREVENTION; DIAGNOSIS;
   ADULTS
AB Study Design. A retrospective study.
   Objective. The aim of this study was to compare the clinical outcomes of continuous irrigation suction systems (CISS) or vacuum-assisted closure system (VACS) in early deep wound infection (DWI) after thoracolumbar instrumentation.
   Summary of Background Data. DWI after thoracolumbar instrumentation is challenging and debridement followed by either CISS or VACS has been proven to be effective. So far, which one of the system has more advantages over the other remains unclear.
   Methods. Patients after thoracolumbar instrumentation were evaluated at our spine surgery center from 2005 to 2015. Patients who were diagnosed with early deep DWI after spinal instrumentation and treated by meticulous debridement in the operating room followed by either CISS or VACS were included. Detailed information was obtained from the medical records, including clinical features, results of laboratory examinations, medical therapies, and outcomes. A follow-up was conducted to observe whether recurrent spinal infection or other complications happened.
   Results. We identified 11 patients in the CISS group and 12 patients in the VACS group. There were no significant differences in terms of age, gender, follow-up duration, symptoms of infection, laboratory examinations, etc. The number of CISS or VACS replacement was 1.3 and 1.6, respectively, before wound healing (P>0.05). And there were significant differences in terms of hospital stay and extra cost of infection treatment between the two groups. In the follow-up period, we observed sinus tract formation and low back pain in both groups and one patient in the VACS group died of pulmonary infection 4 years after the initial surgery.
   Conclusion. Thorough debridement followed by CISS or VACS are comparable in treating early DWI after thoracolumbar instrumentation. The CISS treatment was statistically significant in comparison to the VACS treatment in terms of hospital stay and cost.
C1 [Yuan, Wei; Liu, Xuan; Zhou, Xiaoshu; Pei, Lei; Zhu, Yue] China Med Univ, Hosp 1, Dept Orthoped, Shenyang, Liaoning, Peoples R China.
C3 China Medical University
RP Zhu, Y (通讯作者)，China Med Univ, Hosp 1, 155 Nanjingbei St, Shenyang 110001, Liaoning, Peoples R China.
EM zhuyuedr@163.com
OI yuan, wei/0000-0003-4012-4350
FU National Key Research and Development Program of China [2017YFC1104903]
FX National Key Research and Development Program of China (2017YFC1104903)
   funds were received in support of this work.
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NR 35
TC 12
Z9 19
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD SEP 15
PY 2018
VL 43
IS 18
BP E1089
EP E1095
DI 10.1097/BRS.0000000000002615
PG 7
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA HD0AE
UT WOS:000452169000007
PM 29481377
DA 2026-07-24
ER

PT J
AU De Caridi, G
   Massara, M
   Greco, M
   Pipitò, N
   Spinelli, F
   Grande, R
   Butrico, L
   de Franciscis, S
   Serra, R
AF De Caridi, Giovanni
   Massara, Mafalda
   Greco, Michele
   Pipito, Narayana
   Spinelli, Francesco
   Grande, Raffaele
   Butrico, Lucia
   de Franciscis, Stefano
   Serra, Raffaele
TI VAC therapy to promote wound healing after surgical revascularisation
   for critical lower limb ischaemia
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Critical lower limb ischaemia; Vacuum-assisted closure therapy; Wound
   healing
ID DIABETIC FOOT ULCERS; ASSISTED CLOSURE; TRIAL; GEL
AB Vacuum-assisted closure (VAC) therapy is a new emerging non-invasive system in wound care, which speeds up wound healing by causing vacuum, improving tissue perfusion and suctioning the exudates, and facilitating the removal of bacteria from the wound. The application of sub-atmospheric pressure on the lesions seems to alter the cytoskeleton of the cells on the wound bed, triggering a cascade of intracellular signals that increase the rate of cell division and subsequent formation of granulation tissue. The aim of this study is to analyse the results of VAC therapy used as an adjuvant therapy for the treatment of foot wounds in patients affected by critical limb ischaemia (CLI) (Rutherford 6 class) after distal surgical revascularisation, to promote and accelerate the healing of ulcers. Twenty-nine patients (20 males, 9 females; mean age 68.4) affected by CLI of Rutherford 6 class, after surgical revascularisation of the lower limb, underwent VAC therapy in order to speed upwound healing. Completewound healingwas achieved in 19 patients (65.51%), in an average period of 45.4 +/- 25.6 days. VAC therapy is a valid aid, after surgical revascularisation, to achieve rapid healing of foot lesions in patients with CLI.
C1 [De Caridi, Giovanni; Massara, Mafalda; Greco, Michele; Pipito, Narayana; Spinelli, Francesco] Univ Messina, Cardiovasc & Thorac Dept, Policlin G Martino Hosp, Messina, Italy.
   [Grande, Raffaele; Butrico, Lucia; de Franciscis, Stefano; Serra, Raffaele] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, Catanzaro, Italy.
   [de Franciscis, Stefano; Serra, Raffaele] Magna Graecia Univ Catanzaro, Int Res & Educ Program Clin & Expt Biotechnol, Interuniv Ctr Phlebolymphol CIFL, Catanzaro, Italy.
C3 University of Messina; University Messina Policlin; Magna Graecia
   University of Catanzaro; Magna Graecia University of Catanzaro
RP Serra, R (通讯作者)，Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy.
EM rserra@unicz.it
RI ; Grande, Raffaele/AAO-1388-2020; De Caridi, Giovanni/KRQ-6363-2024;
   Serra, Raffaele/AAA-6874-2022; /AAM-9453-2020
OI Butrico, Lucia/0000-0002-0536-0705; Greco, Michele/0000-0001-5638-1613;
   Grande, Raffaele/0000-0003-2873-0104; de Franciscis,
   Stefano/0000-0001-9365-4609; De Caridi, Giovanni/0000-0002-1859-9010;
   Serra, Raffaele/0000-0003-4477-7412; 
CR [Anonymous], GUID MAN WOUNDS PAT
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NR 21
TC 20
Z9 22
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
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JI Int. Wound J.
PD JUN
PY 2016
VL 13
IS 3
BP 336
EP 342
DI 10.1111/iwj.12301
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DR5JW
UT WOS:000379940300006
PM 24872149
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ben-Amotz, R
   Lanz, OI
   Miller, JM
   Filipowicz, DE
   King, MD
AF Ben-Amotz, Ron
   Lanz, Otto I.
   Miller, Jonathan M.
   Filipowicz, Dean E.
   King, Michael D.
TI The use of vacuum-assisted closure therapy for the treatment of distal
   extremity wounds in 15 dogs
SO VETERINARY SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE; SKIN; MANAGEMENT; INJURIES; SOFT
AB Objective-To evaluate clinical outcome after vacuum-assisted closure (VAC) therapy in dogs with traumatic wounds located in the distal extremities and report our early experience with VAC.
   Study Design-Retrospective study.
   Animals-Dogs (n=15) with traumatic distal extremity wounds.
   Methods-Medical records (1999-2003) of dogs with traumatic injuries to the distal extremities managed by VAC were evaluated. Data included signalment, location of wound, time until surgical intervention, wound reconstruction methods, orthopedic procedures, outcome, complications associated with VAC, and length of hospitalization.
   Results-The mean number of days until reconstruction was 4.6 days (range, 2-7 days). Reconstructive surgery was successful in all cases. Mean hospitalization was 9.7 days (range, 6-16 days). Complications included dermatitis at the wound margin and loss of vacuum causing wound desiccation.
   Conclusion-VAC therapy can be used to achieve adequate management of traumatic distal extremity wounds. VAC provides an effective method of securing skin grafts over the wound bed.
   Clinical Relevance-VAC therapy can be used as an ancillary treatment for distal extremity wounds in dogs before surgical repair as well as a method for securing skin grafts to the wound bed. (C) Copyright 2007 by The American College of Veterinary Surgeons.
C1 Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University
RP Ben-Amotz, R (通讯作者)，Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24061 USA.
EM ronba1@gmail.com
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NR 36
TC 49
Z9 52
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD OCT
PY 2007
VL 36
IS 7
BP 684
EP 690
DI 10.1111/j.1532-950X.2007.00321.x
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 215SK
UT WOS:000249829100011
PM 17894595
DA 2026-07-24
ER

PT J
AU Wollina, U
   Meseg, A
   Weber, A
AF Wollina, Uwe
   Meseg, Antje
   Weber, Andreas
TI Use of a collagen-elastin matrix for hard to treat soft tissue defects
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Collagen-elastin matrix; deep soft tissue defects; dermal substitutes;
   mesh-graft transplantation; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; DERMAL SUBSTITUTE; MATRIDERM(R); WOUNDS; BURNS;
   GRAFTS; DEVICE
AB As deep soft tissue defects with exposed bone, cartilage or tendons are not suitable for wound closure with skin mesh grafts, other techniques are needed. We report on six patients, one female and five males, aged between 32 and 89 years, and deep soft tissue defects with exposed tendons, cartilage or bone. The aetiology of these defects was vascular (n = 3), tumour surgery (2), and post-traumatic (1). Wounds were treated with a collagen-elastin matrix applied above the exposed structures. In five patients, the procedure was combined with mesh graft transplantation in the same setting. Follow-up varied between 12 and 40 weeks. Wound healing was uncomplicated in all transplanted patients until first dressing change after 7 days. All but one transplant showed a 100% take rate and the transplant was stable within 10-14 days. A complete wound closure was also achieved without transplantation, but this took 8 weeks. No adverse effects were noted. There was no skin contracture of the skin grafts. Collagen-elastin matrix with split-thickness skin grafts is a useful tool in deep soft tissue. The time to heal can be reduced.
C1 [Wollina, Uwe; Meseg, Antje] Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, D-01067 Dresden, Germany.
   [Weber, Andreas] Acad Teaching Hosp Dresden Friedrichstadt, Dept Orthopaed Surg, D-01067 Dresden, Germany.
C3 Technische Universitat Dresden; Municipal Hospital Dresden; Technische
   Universitat Dresden; Municipal Hospital Dresden
RP Wollina, U (通讯作者)，Acad Teaching Hosp Dresden Friedrichstadt, Dept Dermatol & Allergol, Friedrichstr 41, D-01067 Dresden, Germany.
EM wollina-uw@khdf.de
RI Wollina, Uwe/AAJ-9644-2020
OI Wollina, Uwe/0000-0001-5933-2913
CR Banwell P E, 2003, J Wound Care, V12, P22
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NR 22
TC 14
Z9 15
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 291
EP 296
DI 10.1111/j.1742-481X.2011.00785.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900013
PM 21449935
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Gorlitzer, M
   Grabenwoeger, M
   Meinhart, J
   Swoboda, H
   Oczenski, W
   Fiegl, N
   Waldenberger, F
AF Gorlitzer, Michael
   Grabenwoeger, Martin
   Meinhart, Johann
   Swoboda, Herwig
   Oczenski, Wolfgang
   Fiegl, Nikolaus
   Waldenberger, Ferdinand
TI Descending necrotizing mediastinitis treated with rapid sternotomy
   followed by vacuum-assisted therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MANAGEMENT; INFECTIONS; SECONDARY; DRAINAGE; CLOSURE; DISEASE
AB Background. Descending necrotizing mediastinitis (DNM) is a life-threatening emergency after oropharyngeal infection. The diagnosis must be established rapidly. DNM is associated with septic shock and respiratory insufficiency. Because mortality rates may be as high as 60%, aggressive surgical treatment is indicated.
   Methods. Between December 2001 and December 2005, 5 patients ( 3 men, 2 women) with DNM, average age of 69 years ( range, 24 to 72 years), were treated at our department. Surgical treatment consisted of one or more cervical drainages and drainage of the mediastinum through sternotomy after mediastinitis had been confirmed by computed tomography. The latter investigation also revealed mediastinal abscess and empyema. After radical debridement, a vacuum-assisted closure device was inserted. Results. The outcome was favorable in 4 patients. A 72-year-old woman died of prolonged septic shock and subsequent multiple organ failure. Tracheotomy was performed in all patients to create an airway. The duration of the intensive care unit stay was 51 +/- 24.2 days.
   Conclusions. Rapid and extensive cervical and mediastinal debridement is mandatory in patients with DNM. A vacuum-assisted closure device is useful because it promotes tissue approximation and stimulates the ingrowth of granulation tissue. (c) 2007 by The Society of Thoracic Surgeons.
C1 Hosp Hietzing, Dept Cardiovasc Surg, A-1130 Vienna, Austria.
   Hosp Hietzing, Dept Otorhinolaryngol, A-1130 Vienna, Austria.
   Hosp Hietzing, Dept Anaesthesiol, A-1130 Vienna, Austria.
C3 Hietzing Hospital; Hietzing Hospital; Hietzing Hospital
RP Gorlitzer, M (通讯作者)，Hosp Hietzing, Dept Cardiovasc Surg, Wolkersbergenstr 1, A-1130 Vienna, Austria.
EM michael.gorlitzer@wienkav.at
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 21
TC 20
Z9 27
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD FEB
PY 2007
VL 83
IS 2
BP 393
EP 396
DI 10.1016/j.athoracsur.2006.09.059
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 129GM
UT WOS:000243716600007
PM 17257957
DA 2026-07-24
ER

PT J
AU Noh, BG
   Yoon, M
   Park, YM
   Seo, HI
   Kim, S
   Hong, SB
   Park, JK
   Lee, MW
AF Noh, Byeong Gwan
   Yoon, Myunghee
   Park, Young Mok
   Seo, Hyung-Il
   Kim, Suk
   Hong, Seung Baek
   Park, Jae Kyun
   Lee, Moon Won
TI Successful resolution of gastric perforation caused by a severe
   complication of pancreatic walled-off necrosis: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Acute necrotizing pancreatitis; Endoscopy; Vacuum assisted closure;
   Gastric rupture; Surgery; Case report
ID NECROTIZING PANCREATITIS; MANAGEMENT; LEAKS
AB BACKGROUNDPancreatic walled-off necrosis (WON) rarely causes critical gastric necrosis and perforation, which may develop when pancreatic WON squashes against the stomach. The Atlanta 2012 guidelines were introduced for acute pancreatitis and its related clinical entities. However, there are few reported cases describing the clinical course and resolution of pancreatic WON.CASE SUMMARYWe report the case of a 45-year-old man who presented to the urgent emergency department with gastric perforation caused by a severe complication of pancreatic WON on computed tomography. The patient underwent an emergency distal pancreatectomy, splenectomy, and gastric wedge resection. Postoperative findings showed re-perforation of the gastric wall at a previously resected margin. Furthermore, endoscopic examination revealed an ulcerative area with a defect in the fundus. After diagnostic endoscopy, endoscopic vacuum-assisted closure was performed, and continuous suction was transferred over all tissues in contact with the sponge surface. The patient recovered without any further complications and was discharged in good condition at postoperative week 8. No recurrence occurred during the 6-mo follow-up period.CONCLUSIONWhen managing a patient with serious gastric perforation complicated by pancreatic WON, a multidisciplinary treatment approach should be considered.
C1 [Noh, Byeong Gwan; Yoon, Myunghee; Park, Young Mok; Seo, Hyung-Il; Park, Jae Kyun] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, Pusan 49241, South Korea.
   [Kim, Suk; Hong, Seung Baek] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Radiol, Pusan 49241, South Korea.
   [Lee, Moon Won] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Internal Med, Pusan 49241, South Korea.
   [Yoon, Myunghee] Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, 179 Gudeok Ro,Seo Gu, Pusan 49241, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital
RP Yoon, M (通讯作者)，Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst,Sch Med, Dept Surg, 179 Gudeok Ro,Seo Gu, Pusan 49241, South Korea.
EM ymh@pusan.ac.kr
OI Noh, Byeong Gwan/0000-0002-7764-9516
FU Clinical Research Grant from Pusan National University Hospital in 2023
FX Supported by the Clinical Research Grant from Pusan National University
   Hospital in 2023.
CR Banks PA, 2013, GUT, V62, P102, DOI 10.1136/gutjnl-2012-302779
   Bansal A, 2019, JGH OPEN, V3, P450, DOI 10.1002/jgh3.12185
   Beger HG, 2007, WORLD J GASTROENTERO, V13, P5043, DOI 10.3748/wjg.v13.i38.5043
   Besselink MG, 2009, BRIT J SURG, V96, P267, DOI 10.1002/bjs.6447
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   Yang Y, 2023, WORLD J EMERG SURG, V18, DOI 10.1186/s13017-023-00479-7
NR 13
TC 0
Z9 0
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD SEP 16
PY 2023
VL 11
IS 26
BP 6298
EP 6303
DI 10.12998/wjcc.v11.i26.6298
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA S4XK4
UT WOS:001071211000033
PM 37731568
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Canavese, F
   Krajbich, JI
AF Canavese, Federico
   Krajbich, Joseph I.
TI Use of vacuum assisted closure in instrumented spinal deformities for
   children with postoperative deep infections
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE VAC therapy; deep wound infection; spinal deformity
ID WOUND CONTROL; MANAGEMENT; ADULTS; FUSION; SOFT
AB Background: Postoperative deep infections are relatively common in children with instrumented spinal deformities, whose healing potential is somewhat compromised. Children with underlying diagnosis of cerebral palsy, spina bifida and other chronic debilitating conditions are particularly susceptible. Vacuum-assisted closure (VAC) is a newer technique to promote healing of wounds resistant to treatment by established methods. This article aims to review the efficacy of the VAC system in the treatment of deep spinal infections following spinal instrumentation and fusion in children and adolescents. Materials and Methods: We reviewed 33 patients with deep postoperative surgical site infection treated with wound VAC technique. We reviewed clinical and laboratory data, including the ability to retain the spinal hardware, loss of correction and recurrent infections. Results : All patients successfully completed their wound VAC treatment regime. None had significant loss of correction and one had persistent infection requiring partial hardware removal. The laboratory indices normalized in all but three patients. Conclusions: Wound VAC technique is a useful tool in the armamentarium of the spinal surgeon dealing with patients susceptible to wound infections, especially those with neuromuscular diseases. It allows for retention of the instrumentation and maintenance of the spinal correction. It is reliable and easy to use.
C1 [Canavese, Federico; Krajbich, Joseph I.] Shriners Hosp Children, Dept Orthoped, Portland, OR 97239 USA.
RP Canavese, F (通讯作者)，Shriners Hosp Children, Dept Orthoped, 3101 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM canavese_federico@yahoo.fr
OI CANAVESE, Federico/0000-0002-6114-5372
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   SKOZE G, 1998, J PEDIATR ORTHOPED, V18, P727
   Soultanis K, 2003, CLIN ORTHOP RELAT R, P116, DOI 10.1097/01.blo.0000068357.47147.10
   Sriram K, 1972, J Bone Joint Surg Br, V54, P666
   URSCHEL JD, 1988, BRIT J PLAST SURG, V41, P182, DOI 10.1016/0007-1226(88)90049-5
NR 25
TC 10
Z9 10
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD APR-JUN
PY 2010
VL 44
IS 2
BP 177
EP 183
DI 10.4103/0019-5413.62067
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 586AM
UT WOS:000276873100008
PM 20419005
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Wedemeyer, J
   Brangewitz, M
   Kubicka, S
   Jackobs, S
   Winkler, M
   Neipp, M
   Klempnauer, J
   Manns, MP
   Schneider, AS
AF Wedemeyer, Jochen
   Brangewitz, Mira
   Kubicka, Stefan
   Jackobs, Steffan
   Winkler, Michael
   Neipp, Michael
   Klempnauer, Juergen
   Manns, Michael P.
   Schneider, Andrea S.
TI Management of major postsurgical gastroesophageal intrathoracic leaks
   with an endoscopic vacuum-assisted closure system
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID ESOPHAGEAL ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; GASTRIC-CARCINOMA;
   PLASTIC STENTS; FIBRIN GLUE; SURGERY; PERFORATIONS; EXPERIENCE; FISTULAS
AB Background: Endoscopic treatment options for postsurgical intrathoracic leaks include injection of fibrin glue, clip application, and stent placement. Endoscopic vacuum-assisted Closure (E-VAC) may be an effective treatment option.
   Objective: To demonstrate that E-VAC is an effective endoscopic treatment option for Closure of major intrathoracic postsurgical leaks.
   Design and Setting: A prospective, single-center Study at an academic medical center.
   Patients: Eight consecutive patients with major intrathoracic postsurgical leaks.
   Interventions: Endoscopic placement of transnasal draining tubes, armed With a size-adjusted sponge at their distal end, in the necrotic anastomotic cavities, followed by continuous suction. Sponge and drainage were changed twice weekly. Patients were followed-up for 1.93 +/- 137 days.
   Main Outcome Measurement: Successful leak closure.
   Results: Successful Closure of leaks was achieved in 7 of 8 patients (88%) after a mean of 23 +/- 8 clays. A median of 7 endoscopic interventions was necessary. No major treatment-associated short-term or long-term (follow-up, 193 +/- 137 clays) complications were noted.
   Limitations: Small sample size, single-center study, and lack of randomization.
   Conclusion: E-VAC is an effective endoscopic treatment modality for major postsurgical intrathoracic leaks.
C1 [Wedemeyer, Jochen; Brangewitz, Mira; Kubicka, Stefan; Manns, Michael P.; Schneider, Andrea S.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany.
   [Jackobs, Steffan; Winkler, Michael; Neipp, Michael; Klempnauer, Juergen] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, D-30625 Hannover, Germany.
   [Neipp, Michael] Klinikum Itzehoe, Dept Gen Vasc & Visceral Surg, Itzehoe, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM wedemeyer.jochen@mh-hannover.de
RI Manns, Michael/AFG-3063-2022
CR Choudhury SH, 2001, AM J ROENTGENOL, V176, P161, DOI 10.2214/ajr.176.1.1760161
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NR 26
TC 79
Z9 91
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD FEB
PY 2010
VL 71
IS 2
BP 382
EP 386
DI 10.1016/j.gie.2009.07.011
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 558VT
UT WOS:000274777200026
PM 19879566
DA 2026-07-24
ER

PT J
AU Loos, B
   Kopp, J
   Hohenberger, W
   Horch, RE
AF Loos, B.
   Kopp, J.
   Hohenberger, W.
   Horch, R. E.
TI Post-malignancy irradiation ulcers with exposed alloplastic materials
   can be salvaged with topical negative pressure therapy (TNP)
SO EJSO
LA English
DT Article; Proceedings Paper
CT Dreilaender Congress
CY 2004
CL Mainz, GERMANY
DE topical negative pressure; cancer; irradiated tissue; alloplastic
   material; oncologic surgery
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; WOUND CONTROL; SURGERY;
   COMPLICATIONS; PENETRATION; EXPERIENCE; RADIATION; MUSCLE
AB Aim: The aim of this study was to salvage or to integrate exposed alloplastic meshes in post malignancy irradiated chronic wounds by using topical negative pressure (TNP) therapy together with staged debridement.
   Methods: Three patients with secondarily exposed alloplastic meshes in irradiated non-healing wounds were treated by serial debridement and repeated topical negative pressure therapy until clean and vital wounds were achieved, followed by ultimate plastic coverage by a myocutancous flap or split-thickness skin graft. The range of the follow-up period was from 18 to 36 months.
   Results: After staged serial debridement and repeated vacuum treatment periods wounds were preconditioned in an acceptable fashion for ultimate plastic coverage. After the treatment with a myocutaneous flap or split-thickness skin graft all three patients achieved long-term stable wounds with no alloplastic mesh complication within the follow-up period.
   Conclusion: Computer-controlled TNP therapy (vacuum-assisted closure therapy) together with staged debridement can help to induce granulation tissue formation in irradiated wounds and allows integration of alloplastic materials into regenerating wounds after ablative oncologic surgery. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Univ Erlangen Nurnberg, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Dept Surg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Loos, B (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM bernd.loos@online.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
CR Aflatoon K, 2003, CLIN ORTHOP RELAT R, P248, DOI 10.1097/01.blo.0000093886.12372.74
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NR 32
TC 12
Z9 13
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0748-7983
EI 1532-2157
J9 EJSO-EUR J SURG ONC
JI EJSO
PD SEP
PY 2007
VL 33
IS 7
BP 920
EP 925
DI 10.1016/j.ejso.2006.12.018
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology; Surgery
GA 212PR
UT WOS:000249609800019
PM 17289332
DA 2026-07-24
ER

PT J
AU Sjögren, J
   Mokhtari, A
   Gustafsson, R
   Malmsjö, M
   Nilsson, J
   Ingemansson, R
AF Sjogren, Johan
   Mokhtari, Arash
   Gustafsson, Ronny
   Malmsjo, Malin
   Nilsson, Johan
   Ingemansson, Richard
TI Vacuum-assisted closure therapy for deep sternal wound infections: the
   impact of learning curve on survival and predictors for late mortality
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Mediastinitis; Postoperative complications; Surgical wound infection
AB The aim of this study was to evaluate the possible learning curve effects on survival during the introduction of vacuum-assisted closure (VAC) therapy in patients with deep sternal wound infection (DSWI). Furthermore, predictors of late mortality were analysed and causes of late death were examined. Fifty-three patients (early Group, n = 26, January 1999 to July 2001 versus late group, n = 27, August 2001 to March 2003) were all treated with VAC for DSWI. A follow-up was carried out in September 2006. Multivariate analyses were used to evaluate the predictors of late mortality. The 90-day mortality was 0% in both groups. The survival rates at 5 years were 69.2 +/- 9.1% (early group) versus 58.5 +/- 11.7% (late group), P = ns (non significant). The time interval from cardiac surgery to diagnosis of DSWI and prolonged VAC therapy were identified as independent predictors of late mortality. Our concept for VAC therapy in DSWI seems to be readily introduced in clinical practice. There was no difference in survival between our initial cases and later cases. Late diagnosis and prolonged wound therapy were identified as predictors for late mortality.
C1 [Sjogren, Johan] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Sjögren, J (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, SE-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI ; Nilsson, Johan/A-4742-2011; Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Nilsson, Johan/0000-0001-6860-6090;
   Ingemansson, Richard/0000-0001-7623-8953; 
FU Region Skane Research Funds; Lund University Hospital
FX This study was made possible by grants from the Region Skane Research
   Funds and the Donation Funds of Lund University Hospital. Financial
   disclosure: JS, RG, MM and RI have received lecture honorarium from KCI
   Europe.
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NR 24
TC 18
Z9 19
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 216
EP 223
DI 10.1111/j.1742-481X.2007.00371.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500010
PM 18494627
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Wagner, S
   Greco, F
   Hoda, MR
   Kawan, F
   Heynemann, H
   Fornara, P
AF Wagner, Sigrid
   Greco, Francesco
   Hoda, M. Raschid
   Kawan, Felix
   Heynemann, Hans
   Fornara, Paolo
TI Is Intensive Multimodality Therapy the Best Treatment for Fournier
   Gangrene? Evaluation of Clinical Outcome and Survival Rate of 41
   Patients
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; HYPERBARIC-OXYGEN;
   SEVERITY INDEX; RISK-FACTORS; STRATEGIES
AB Background: To evaluate the effect of surgical wound debridement, antibiotics, and hyperbaric oxygen (HBO) in the treatment of Fournier gangrene (FG).
   Methods: Forty-one patients with a mean age of 54.3 +/- 14.6 years were referred to our department with a diagnosis of FG. To calculate a Fourier Gangrene Severity Index (FGSI), nine factors were assessed (temperature; heart rate; ventilatory rate; serum sodium, potassium, creatinine, and bicarbonate concentrations; hematocrit; and leukocyte count). After clinical stabilization, extensive debridement of the necrotic tissue was performed, and a surgical vacuum-assisted closure (V. A. C.(R)) device was applied. Hyperbaric oxygen was administered; medical therapy consisted of intravenous antibiotics, electrolyte replacement, and parenteral nutrition.
   Results: Intraoperative cultures revealed Escherichia coli in 27 patients (66%), Pseudomonas aeruginosa in 28 (68%), gram-positive cocci in 24 (59%), and mixed flora (aerobic and anaerobic bacteria) in 39 (95%). One month after primary debridement, wound granulation was sufficient for plastic surgical reconstruction in all patients.
   Conclusion: Because of the rapid worsening of FG, early diagnosis and immediate, aggressive multi-modality therapy with surgical debridement and broad-spectrum empiric antibiotics is crucial. The utility of HBO remains unproved.
C1 [Greco, Francesco] Univ Halle Wittenberg, Urol Clin, Dept Urol & Kidney Transplantat, D-06120 Halle, Germany.
C3 Martin Luther University Halle Wittenberg
RP Greco, F (通讯作者)，Univ Halle Wittenberg, Urol Clin, Dept Urol & Kidney Transplantat, Ernst Grube Str 40, D-06120 Halle, Germany.
EM francesco.greco@medizin.uni-halle.de
RI Greco, Francesco/GPK-1147-2022
OI Greco, Francesco/0000-0002-9466-3029
CR [Anonymous], 1883, SEMIN MED
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NR 22
TC 10
Z9 12
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2011
VL 12
IS 5
BP 379
EP 383
DI 10.1089/sur.2010.091
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 846MB
UT WOS:000296905900009
PM 21943303
DA 2026-07-24
ER

PT J
AU Bihariesingh, VJ
   Stolarczyk, EM
   Karim, RB
   van Kooten, EO
AF Bihariesingh, VJ
   Stolarczyk, EM
   Karim, RB
   van Kooten, EO
TI Plastic solutions for orthopaedic problems
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE postoperative wounds; plastic surgery; flaps; osteosynthesis;
   arthroplasty
ID VACUUM-ASSISTED CLOSURE; PROSTHESIS; COVERAGE
AB Introduction: Infection and exposure of the implant may occur in 1-12% of patients operated on for arthroplasty or osteosynthesis. Variables such as tissue viability, presence of infection, exposure of osteosynthesis material and patient-related factors contribute to the lack of general consensus regarding the management of these defects. Materials and methods: Between January 1999 and January 2001, six patients were treated for complex soft-tissue defects following various orthopaedic procedures at the Department of Plastic Surgery in the Slotervaartziekenhuis in Amsterdam, a rheuma-orthopaedic orientated hospital. All patients were initially treated by radical debridement and vacuum-assisted closure ( VAC) system of the wound. After 1 week, this was followed by transplantation of a pedicled or free flap to cover the defect. We studied the medical history, initial orthopaedic procedure, wound treatment, transplanted flap and outcome of plastic surgery in this group. Results: Plastic surgical intervention led to wound closure in all cases. In only one case was the osteosynthesis material removed because of osteomyelitis. Conclusions: We conclude that the earlier coverage with vital tissue is obtained, the lower the incidence of infection. Early consultation by a plastic surgeon will increase a positive outcome of treatment of complex tissue defects.
C1 Onze Lieve Vrouw Hosp, Dept Plast & Reconstruct Surg, NL-1090 HM Amsterdam, Netherlands.
   Acad Ziekenhuis, Dept Orthopaed Surg, Paramaribo, Suriname.
C3 Onze Lieve Vrouwe Gasthuis Hospital
RP Karim, RB (通讯作者)，Onze Lieve Vrouw Hosp, Dept Plast & Reconstruct Surg, POB 95500, NL-1090 HM Amsterdam, Netherlands.
EM rbkarim@xs4all.nl
OI Karim, Refaat B/0000-0001-8162-2140
CR ADAM RF, 1994, J BONE JOINT SURG BR, V76B, P750, DOI 10.1302/0301-620X.76B5.8083264
   CHANDRASEKHAR B, 1993, ORTHOP CLIN N AM, V24, P523
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   GERWIN M, 1993, CLIN ORTHOP RELAT R, V286, P64
   GREENBERG B, 1989, PLAST RECONSTR SURG, V83, P85, DOI 10.1097/00006534-198901000-00016
   HALLOCK GG, 1995, PLAST SURG TECH, V1, P47
   JOHNSON DP, 1993, ACTA ORTHOP SCAND S, V252, P5
   Kramhoft M, 1994, J Arthroplasty, V9, P617, DOI 10.1016/0883-5403(94)90115-5
   LAING JHE, 1992, BRIT J PLAST SURG, V45, P66
   LESAVOY MA, 1989, PLAST RECONSTR SURG, V83, P90, DOI 10.1097/00006534-198901000-00017
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   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
   TAYLOR S, 1994, CAN J SURG, V37, P217
NR 16
TC 18
Z9 27
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD MAR
PY 2004
VL 124
IS 2
BP 73
EP 76
DI 10.1007/s00402-003-0615-8
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 780GT
UT WOS:000189364500001
PM 14730453
DA 2026-07-24
ER

PT J
AU Min, YW
   Kim, T
   Lee, H
   Min, BH
   Kim, HK
   Choi, YS
   Lee, JH
   Rhee, PL
   Kim, JJ
   Zo, JI
   Shim, YM
AF Min, Yang Won
   Kim, Taewan
   Lee, Hyuk
   Min, Byung-Hoon
   Kim, Hong Kwan
   Choi, Yong Soo
   Lee, Jun Haeng
   Rhee, Poong-Lyul
   Kim, Jae J.
   Zo, Jae Ill
   Shim, Young Mog
TI Endoscopic vacuum therapy for postoperative esophageal leak
SO BMC SURGERY
LA English
DT Article
DE Endoscopic vacuum-assisted closure; Esophagectomy; Leak
ID ANASTOMOTIC LEAK; ASSISTED CLOSURE; MANAGEMENT; STENT; COMPLICATIONS
AB Background: Anastomotic leak is the most common and serious complication following esophagectomy. Endoscopic vacuum-assisted closure (EVAC) is a promising method for treating anastomotic leak. We aimed to evaluate the efficacy of EVAC and to identify factors associated with longer treatment duration for esophageal anastomotic leak following esophagectomy for cancer.
   Methods: We retrospectively analyzed 20 esophageal cancer patients who had undergone EVAC for anastomotic leak after esophagectomy. The efficacy and success rates were evaluated and factors associated with longer treatment duration (>= 21 days) were identified.
   Results: All 20 patients were male. Of these, 10 (50.0%) received neoadjuvant treatment and 6 (30.0%) had one or more comorbidities. The median size of fistula opening was 1.75 cm. During a median of 14.5 days of EVAC treatment, a median of 5 interventions were performed. Treatment success was achieved in 19 patients (95.0%). Neoadjuvant treatment was significantly associated with longer EVAC treatment. There was a non-significant trend toward the need for longer treatment duration for a larger fistula opening size.
   Conclusions: EVAC treatment is a good non-surgical option for anastomotic leak following esophagectomy. Long duration of treatment is associated with neoadjuvant treatment and a large leakage opening.
C1 [Min, Yang Won; Kim, Taewan; Lee, Hyuk; Min, Byung-Hoon; Lee, Jun Haeng; Rhee, Poong-Lyul; Kim, Jae J.] Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea.
   [Kim, Hong Kwan; Choi, Yong Soo; Zo, Jae Ill; Shim, Young Mog] Sungkyunkwan Univ, Dept Thorac & Cardiovasc Surg, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Zo, JI (通讯作者)，Sungkyunkwan Univ, Dept Thorac & Cardiovasc Surg, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM yangwonee@gmail.com; jayl.zo@samsung.com
RI ; Rhee, Poong/C-9655-2011
OI Min, Yang Won/0000-0001-7471-1305; Choi, Yong Soo/0000-0002-2552-0067;
   Min, Byung-Hoon/0000-0001-8048-361X; 
FU National R&D Program for Cancer Control, Ministry of Health Welfare,
   Korea [1720180]
FX Professor Jae Ill Zo, who coordinated the study and edited the
   manuscript, was supported by the following grant(s): The National R&D
   Program for Cancer Control, Ministry of Health & Welfare, Korea
   (1720180).
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Whooley BP, 2001, AM J SURG, V181, P198, DOI 10.1016/S0002-9610(01)00559-1
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NR 23
TC 54
Z9 60
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 11
PY 2019
VL 19
AR 37
DI 10.1186/s12893-019-0497-5
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HT9JY
UT WOS:000464886800002
PM 30975210
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nord, D
AF Nord, D
TI Cost-effectiveness in wound care
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE wound healing; vacuum assisted closure; effectiveness; efficiency;
   costs; savings
ID ULCER PREVALENCE; THERAPY
AB Introduction: In Germany, treatment costs for pressure ulcer, diabetic foot ulcer and ulcus cruris sum up to Euro 5 billion p. a. (cost of materials only). The question is to be answered how much money could be saved to sick funds, if the treatment is switched from traditional wound care, e.g. hydrocolloids to Vacuum Assisted Closure (V.A.C.(R)). Methods: Clinical studies are analysed with regard to complication rates and speed of wound healing V.A.C.(R) vs. traditional. Daily costs and the length of treatment are then correlated and compared. Results: V.A.C.(R) therapy significantly reduces the time for the wound closing process, hospital admissions and complication rates. Despite higher daily treatment costs (cost of material, only), the V.A.C.(R) therapy turns out to be the superior cost-effective method by far. Assumed V.A.C.(R) therapy substitutes other methods by 50%, sick funds could have saved Euro 0.7 billion p. a. Discussion: The V.A.C.(R) related saving potential is not available to sick funds because the approval process for home care use is still (Jan 2006) ongoing since 1999. The improvement of the relevant decision making process is strongly required to faster provide better care and savings at the same time.
C1 Univ Konstanz, D-69118 Heidelberg, Germany.
C3 University of Konstanz
RP Nord, D (通讯作者)，Univ Konstanz, Schweizertalstr 10, D-69118 Heidelberg, Germany.
EM dietrich.nord@drnord.com
CR ANDERSSON E, 1993, ACTA DERM-VENEREOL, V73, P57
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Pelka R, 1997, Krankenpfl J, V35, P338
   Philbeck T E Jr, 1999, Ostomy Wound Manage, V45, P41
   Schwien T, 2005, OSTOMY WOUND MANAG, V51, P47
   WILLY C, 2003, ULM              NOV, P101
   WILLY C, 2003, VAKUUMVERSIEGELUNGST
   2006, VORSTANDSGEHALTER SO
   2000, BERUFSFACHVERBAND ME
NR 10
TC 15
Z9 17
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S185
EP S188
DI 10.1055/s-2006-921433
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100046
PM 16575679
DA 2026-07-24
ER

PT J
AU Waked, K
   Ballaux, P
   Goossens, D
   Cathenis, K
AF Waked, Karl
   Ballaux, Philippe
   Goossens, Dominique
   Cathenis, Koen
TI The "Two Bridges Technique' for sternal wound closure. The use of
   vacuum-assisted closure for the treatment of deep sternal wound defects:
   a centre-specific technique
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Deep sternal wound infection; Mediastinitis; Sternitis; VAC
ID POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; RISK-FACTORS; INFECTION;
   THERAPY; ALGORITHM; SURVIVAL; FLAPS
AB The objective is to describe the Two Bridges Technique' (TBT), which has proven to be successful and has been the standard technique at our centre for vacuum-assisted closure (VAC) of post-sternotomy mediastinitis. An extensive literature search was performed in four databases to identify all published articles concerning VAC for post-sternotomy mediastinitis. Several VAC methods have been used; however, no article has described our specific technique. TBT consists of a two-bridges construction using two types of foam with different pore sizes, which ensures an equally divided negative pressure over the wound bed and stabilisation of the chest. This guarantees a continuous treatment of the sternal defect and prevents foam displacement. It maintains an airtight seal that prevents skin maceration and provides enough protection to avoid right ventricular rupture. The main advantage of TBT is the prevention of shifting or tilting of the foam during chest movements such as breathing or couching. Along with targeted antibiotic treatment, this alternative VAC technique can be an asset in the sometimes cumbersome treatment of post-sternotomy mediastinitis.
C1 [Waked, Karl; Ballaux, Philippe; Goossens, Dominique; Cathenis, Koen] AZ Maria Middelares Gent, Dept Cardiac Surg, Francois Spaestr 1, B-9090 Ghent, Belgium.
RP Waked, K (通讯作者)，AZ Maria Middelares Gent, Dept Cardiac Surg, Francois Spaestr 1, B-9090 Ghent, Belgium.
EM karl.waked@icloud.com
RI Ballaux, Philippe/JBI-9059-2023
OI Ballaux, Philippe/0009-0000-7979-6467; Waked, Karl/0000-0002-7409-5626
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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NR 26
TC 4
Z9 4
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2018
VL 15
IS 2
BP 198
EP 204
DI 10.1111/iwj.12823
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GD6WI
UT WOS:000430649000004
PM 29430829
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ichioka, S
   Watanabe, H
   Sekiya, N
   Shibata, M
   Nakatsuka, T
AF Ichioka, Shigeru
   Watanabe, Hiromi
   Sekiya, Naomi
   Shibata, Masahiro
   Nakatsuka, Takashi
TI A technique to visualize wound bed microcirculation and the acute effect
   of negative pressure
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CUTANEOUS BLOOD-FLOW; PERFUSION; FOUNDATION;
   STATE; MODEL
AB Although previous studies have proved that subatmospheric pressure in vacuum assisted closure therapy increased blood flow at the wound edge, no reports have presented data on blood flow in the wound bed. This study examined a technique that visualized microcirculation of the wound bed and estimated the acute effect of negative pressure. The superficial stratum of the mouse gluteal skin was microsurgically excised preserving the subdermal vascular plexus. The preserved vessels were visualized as the wound bed microcirculation using an intravital microscope-video-computer system. Three levels of negative pressure (-125 mmHg [n=12], -500 mmHg [n=12], 0 mmHg [n=8]) were applied to the wound. Our experimental model successfully and quantitatively visualized wound bed microcirculation under negative pressure application. A negative pressure of -125 mmHg significantly increased wound bed blood flow immediately after pressure application, maintained for 1 minute after pressure release, whereas in the -500 mmHg group blood flow decreased with time and reached a statistically significant level 5 minutes after pressure application. These findings reinforce the hypothesis that enhanced blood flow in the wound bed as well as at the wound edge may contribute to the beneficial effects of certain levels of negative pressure therapy for wound perfusion.
C1 [Ichioka, Shigeru; Watanabe, Hiromi; Sekiya, Naomi; Nakatsuka, Takashi] Saitama Med Univ, Dept Plast & Reconstruct Surg, Moroyama, Saitama 3500495, Japan.
   [Shibata, Masahiro] Univ Tokyo, Grad Sch Med, Dept Biomol Engn, Tokyo, Japan.
C3 Saitama Medical University; University of Tokyo
RP Ichioka, S (通讯作者)，Saitama Med Univ, Dept Plast & Reconstruct Surg, 38 Morohongo, Moroyama, Saitama 3500495, Japan.
EM ichioka-stm@umin.ac.jp
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Sheikh AY, 2005, WOUND REPAIR REGEN, V13, P303, DOI 10.1111/j.1067-1927.2005.130313.x
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
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NR 16
TC 72
Z9 82
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2008
VL 16
IS 3
BP 460
EP 465
DI 10.1111/j.1524-475X.2008.00390.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 298DL
UT WOS:000255666500017
PM 18471264
OA Bronze
DA 2026-07-24
ER

PT J
AU Katsogridakis, E
   Pokusevski, G
   Perricone, V
AF Katsogridakis, Emmanuel
   Pokusevski, Goran
   Perricone, Vittorio
TI The role of sartorius muscle flaps in the management of complex groin
   wounds
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Review; Sartorius muscle flap; Myoplasty; Rotational flap
AB A best evidence topic in vascular surgery was written according to a structured protocol. The question addressed was whether sartorius muscle flaps (SMF) can be effectively used in the setting of complex groin wounds with exposed prosthetic grafts for graft salvage and limb salvage. The literature review identified 33 articles reporting on the use of SMF for complex vascular wounds. Of these, 7 articles reporting on the use of 539 SMFs were considered the best evidence to answer the clinical question. Indications included surgical site infections with or without wound dehiscence, lymph leaks, graft infection and groin pseudoaneurysms, whereas in 98 of the included 539 cases, the flaps were performed prophylactically. Vacuum-assisted closure systems were used in 25 cases to promote healing. The use of an SMF is associated with low rates of muscle flap and graft complications, whereas outcomes seem to be independent of the presence of occlusive disease in the superficial femoral artery. They can be effectively combined with aggressive debridement strategies and vacuum-assisted closure devices to optimize outcomes. The published literature supports the use of SMF in the management of complex groin wounds following vascular reconstruction and is associated with encouraging flap, limb and graft salvage rates.
C1 [Katsogridakis, Emmanuel; Perricone, Vittorio] East Lancashire Hosp NHS Trust, Royal Blackburn Hosp, Dept Vasc Surg, Blackburn, Lancs, England.
   [Katsogridakis, Emmanuel] Univ Hosp South Manchester, Educ & Res Ctr, Acad Surg Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
   [Pokusevski, Goran] Tameside & Glossop Integrated Care NHS Fdn Trust, Dept Surg, Tameside, England.
C3 Wythenshawe Hospital NHS Foundation Trust
RP Katsogridakis, E (通讯作者)，Univ Hosp South Manchester, Educ & Res Ctr, Acad Surg Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
EM e.katsogridakis@nhs.net
OI Katsogridakis, Emmanuel/0000-0001-8551-3910
CR Armstrong PA, 2007, J VASC SURG, V46, P71, DOI 10.1016/j.jvs.2007.02.058
   Brewer MB, 2015, AM SURGEON, V81, P1163
   Dunning Joel, 2003, Interact Cardiovasc Thorac Surg, V2, P405, DOI 10.1016/S1569-9293(03)00191-9
   Fischer JP, 2013, J PLAST RECONSTR AES, V66, P1396, DOI 10.1016/j.bjps.2013.06.014
   Landry GJ, 2009, AM J SURG, V197, P655, DOI 10.1016/j.amjsurg.2008.12.020
   Mirzabeigi MN, 2017, ANN VASC SURG, V43, P232, DOI 10.1016/j.avsg.2017.02.010
   Ryu Dong Yeon, 2016, Vasc Specialist Int, V32, P11, DOI [10.5758/vsi.2016.32.1.11, 10.5758/vsi.2016.32.1.11]
   Töpel I, 2011, J VASC SURG, V53, P1014, DOI [10.1016/j.jvs.2010.11.047, 10.1016/j.jvs.2010.10.047]
NR 8
TC 8
Z9 9
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD APR
PY 2019
VL 28
IS 4
BP 635
EP 637
DI 10.1093/icvts/ivy300
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA JF2YB
UT WOS:000491251000021
PM 30445497
OA Bronze
DA 2026-07-24
ER

PT J
AU Bleszynski, MS
   Chan, T
   Buczkowski, AK
AF Bleszynski, Michael S.
   Chan, Tiffany
   Buczkowski, Andrzej K.
TI Open abdomen with negative pressure device vs primary abdominal closure
   for the management of surgical abdominal sepsis: a retrospective review
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal sepsis; Open abdomen; Vacuum assisted closure; On-demand
   laparotomy; APACHE-1V
ID DAMAGE CONTROL; PLANNED RELAPAROTOMY; HOSPITAL MORTALITY; SEVERE
   PERITONITIS; ACUTE PHYSIOLOGY; ON-DEMAND; INFECTION; METAANALYSIS;
   SURGERY; THERAPY
AB BACKGROUND: Open abdomen with temporary abdominal closure remains a controversial management strategy for surgical abdominal sepsis compared with primary abdominal closure (PAC) and on-demand laparotomy. The primary objective was to compare mortality between PAC and open abdomen with vacuum assisted closure (VAC).
   METHODS: Retrospective review of a tertiary center intensive care unit database (2006 to 2010) including suspected/diagnosed severe abdominal sepsis/septic shock requiring source control laparotomy. Groups were categorized according to closure method at index source control laparotomy. APACHE-IV was used as a measure of disease severity.
   RESULTS: Of 211 patients, 75 PAC and 136 VAC cases were included. Controlling for disease severity, adjusted odds ratio of mortality for VAC was .41 95% confidence interval (.21, .81; P = .01) compared with PAC. PAC and VAC APACHE-1V predicted mortality rate were both 45%. VAC mortality was lower than PAC (22.8% vs 38.6%; P = .012).
   CONCLUSIONS: Open abdomen with VAC is associated with significantly improved survival compared with PAC in abdominal sepsis requiring laparotomy. (C) 2016 The Authors. Published by Elsevier Inc.
C1 [Bleszynski, Michael S.; Chan, Tiffany; Buczkowski, Andrzej K.] Univ British Columbia, Vancouver Gen Hosp, Dept Gen Surg, Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Vancouver Gen Hosp, Dept Gen Surg, Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
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NR 27
TC 25
Z9 35
U1 0
U2 5
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2016
VL 211
IS 5
BP 926
EP 931
DI 10.1016/j.amjsurg.2016.01.012
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DL7BR
UT WOS:000375795000026
PM 27020900
OA hybrid
DA 2026-07-24
ER

PT J
AU Wahab, NAA
   Saadeh, FA
   Wong, A
   Gleeson, N
AF Wahab, N. A. A.
   Saadeh, F. A.
   Wong, A.
   Gleeson, N.
TI Negative pressure wound treatment (NPWT) in vulva and groin wounds in
   gynaecologic oncology
SO EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
LA English
DT Article
DE Vulva and groin wounds; Negative pressure wound treatment
ID VACUUM-ASSISTED CLOSURE; VAGINAL RECONSTRUCTION; NEOVAGINAL
   RECONSTRUCTION; CANCER; FLAP; COMPLICATIONS; MANAGEMENT; THERAPY;
   OMENTOPLASTY; EXENTERATION
AB Secondary healing of complicated vulvar and groin wounds is a major challenge due to its moist condition and at risk of contamination by colonic flora. Vacuum assisted closure is the controlled application of sub-atmospheric pressure to the local wound environment using a sealed dressing connected to a vacuum pump. Materials and Methods: The NPWT consists of an open-pore polyurethane ether foam sponge, an adhesive cover, fluid collection system, and suction pump that generates negative pressure. Direct application of sponge to blood vessels, bone, nerves or intact skin is avoided. The dressing and tubing are changed every 48-72 hours. Results: Eight patients had NPWT following the vulva and/or groin surgery. Pain during removal of the sponge was the main adverse event requiring narcotic analgesia. All wounds healed completely. One patient is dead of disease progression. Others are alive without disease at four to 48 months. Conclusion: Wound breakdown in vulvar and groin surgery is an infrequent occurrence because of the rarity of full radical excision for vulva cancer and infralevator pelvic exenterative surgery. The present experience with NPWT was favourable.
C1 [Wahab, N. A. A.; Saadeh, F. A.; Wong, A.; Gleeson, N.] St James Hosp, Dept Gynaecol, Gynaecol Oncol Div, Jamess St St, Dublin 8, Ireland.
C3 Trinity College Dublin
RP Gleeson, N (通讯作者)，St James Hosp, Dept Gynaecol, Gynaecol Oncol Div, Jamess St St, Dublin 8, Ireland.
EM noreengleeson@dubgyn.org
RI Abu Saadeh, Feras/AAM-2119-2021
OI Abu Saadeh, Feras/0000-0002-9598-8650
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NR 32
TC 3
Z9 3
U1 0
U2 4
PU I R O G CANADA, INC
PI MONTREAL
PA 4900 COTE ST-LUC, APT#212, MONTREAL, QUEBEC H3W 2H3, CANADA
SN 0392-2936
J9 EUR J GYNAECOL ONCOL
JI Eur. J. Gynaecol. Oncol.
PY 2016
VL 37
IS 5
BP 632
EP 637
DI 10.12892/ejgo3099.2016
PG 6
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA DY4FX
UT WOS:000385055500007
PM 29787000
DA 2026-07-24
ER

PT J
AU Wolvos, T
AF Wolvos, T
TI Wound instillation with negative pressure wound therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article; Proceedings Paper
CT National Vacuum-Assisted Closure Education Conference
CY NOV 05-07, 2004
CL Los Angeles, CA
ID BACITRACIN-IRRIGATION
AB In the following article, some of the antibiotics used have not yet been specifically cleared by the FDA for topical use; accordingly, KCI is not permitted to specifically promote their use. Selection of the appropriate antibiotic for instillation therapy is based on the clinician's experience in his/her practice, including routine manual irrigation. Some of this clinical experience has been published. For the purposes of this publication, the editor (with the permission of the author) has replaced the specific antibiotic name with "an appropriate antibiotic".
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NR 16
TC 6
Z9 13
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
SU S
BP 21S
EP 26S
PG 6
WC Dermatology; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 906AP
UT WOS:000227613200005
DA 2026-07-24
ER

PT J
AU Mallik, D
   Siddeek, RAT
   Ravi, B
   Sharda, P
AF Mallik, Dhiraj
   Siddeek, Rohik Anjum T.
   Ravi, Bina
   Sharda, Prateek
TI Case Series of Necrotising Soft Tissue Infection of Breast-Management
   with Literature Review
SO INDIAN JOURNAL OF SURGERY
LA English
DT Review
DE Necrotising soft tissue infection; Breast NSTI; MRI; LRINEC
ID FASCIITIS; RARE
AB Necrotising soft tissue infection (NSTI) is defined as a progressive necrosis and infectious state of soft tissue with diverse clinical manifestation. NSTI of breast is an uncommon phenomenon which requires aggressive treatment with broad spectrum antibiotics, serial debridement and dressings. Usage of hyperbaric oxygen therapy or negative pressure wound therapy has added a new milestone in management. Here, we have discussed management of three different patients of NSTI breast with literature review.
C1 [Mallik, Dhiraj; Siddeek, Rohik Anjum T.; Ravi, Bina; Sharda, Prateek] All India Inst Med Sci, Integrated Breast Care Ctr IBCC, Rishikesh, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Mallik, D (通讯作者)，All India Inst Med Sci, Integrated Breast Care Ctr IBCC, Rishikesh, India.
EM dhirajmallik09@gmail.com
RI sharda, prateek/GZN-0548-2022
OI sharda, prateek/0000-0002-9682-675X; RAVI, BINA/0000-0001-8894-6674;
   Anjum T Siddeek, Rohik/0000-0002-6106-2630; Mallik,
   Dhiraj/0000-0002-6023-4701
CR Eugster T, 1997, Swiss Surg, V3, P117
   Fayman K, 2017, INT J SURG CASE REP, V31, P221, DOI 10.1016/j.ijscr.2017.01.049
   Gupta A, 2019, J WOUND CARE, V28, P775, DOI 10.12968/jowc.2019.28.11.775
   Marongiu F, 2017, INT WOUND J, V14, P349, DOI 10.1111/iwj.12607
   Shah J, 2001, BRIT J PLAST SURG, V54, P67, DOI 10.1054/bjps.2000.3461
   Simonen SME, 2006, EPIDEMIOL INFECT, V134, P293, DOI 10.1017/S095026880500484X
   Wong CH, 2008, PLAST RECONSTR SURG, V122, p151E, DOI 10.1097/PRS.0b013e318186cd92
   Yang BB, 2015, JPRAS OPEN, V6, P15, DOI [10.1016/j.jpra.2015.05.002, DOI 10.1016/J.JPRA.2015.05.002]
NR 8
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD JUN
PY 2021
VL 83
IS SUPPL 2
SU 2
BP 556
EP 559
DI 10.1007/s12262-020-02624-x
EA OCT 2020
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XV3VI
UT WOS:000574720700001
DA 2026-07-24
ER

PT J
AU Wang, Z
   Feng, C
   Wang
AF Wang, Z.
   Feng, C.
   Wang, X. J.
TI 撤稿声明: Negative Pressure Wound Therapy for Patients With Mediastinitis: A
   Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 27 August 2020, in Wiley Online Library (), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The corresponding author could not be reached for comment regarding the retraction.
CR Wang Z, 2020, INT WOUND J, V17, P2019, DOI 10.1111/iwj.13494
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70646
DI 10.1111/iwj.70646
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0067
UT WOS:001623108400001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Easterlin, B
   Bromberg, W
   Linscott, J
AF Easterlin, Bradley
   Bromberg, William
   Linscott, Jack
TI A novel technique of vacuum-assisted wound closure that functions as a
   delayed primary closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
AB Contaminated midline abdominal wounds are often left open and allowed to close via secondary intention to prevent surgical site infections. Negative pressure wound therapy (NPWT) devices have decreased time of healing by secondary intention when compared to the prior standard of moist dressings. The authors report a modification of NPWT that utilizes the unique characteristics of the negative pressure system to achieve delayed primary closure while preventing surgical site infections by continuously draining the wound effluent.
C1 [Easterlin, Bradley; Bromberg, William; Linscott, Jack] Mem Hlth Univ Med Ctr, Savannah, GA 31404 USA.
RP Easterlin, B (通讯作者)，Mem Hlth Univ Med Ctr, 4700 Waters Ave, Savannah, GA 31404 USA.
EM easterlin_nb@yahoo.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell PE, 1999, WOUND REPAIR REGEN, V7, pA287
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   WYSOCKI AB, 1993, J INVEST DERMATOL, V101, P64, DOI 10.1111/1523-1747.ep12359590
NR 5
TC 11
Z9 18
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2007
VL 19
IS 12
BP 331
EP 333
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 245HF
UT WOS:000251925000002
PM 25942681
DA 2026-07-24
ER

PT J
AU Morisaki, A
AF Morisaki, Akimasa
TI A combination of hydrodebridement with pulsed lavage and negative
   pressure wound therapies may enhance outcomes
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Editorial Material
ID OMENTAL FLAP TRANSPOSITION; VACUUM-ASSISTED CLOSURE; INFECTION;
   MEDIASTINITIS; MANAGEMENT; STRATEGY
AB Deep sternal wound infection (DSWI) with prosthetic graft infection is a rare, though lethal, complication after cardiovascular surgery via median sternotomy. This commentary is a review of a report by Takagi et al. published in the Journal of Cardiac Surgery that reported favorable outcomes in patients with DWSI with prosthetic graft infection treated with an enhanced strategy consisting of hydrodebridement with pulsed lavage and negative pressure wound therapies.
C1 [Morisaki, Akimasa] Osaka Metropolitan Univ, Dept Cardiovasc Surg, Grad Sch Med, Osaka, Japan.
C3 Osaka Metropolitan University
RP Morisaki, A (通讯作者)，Osaka Metropolitan Univ, Dept Cardiovasc Surg, Grad Sch Med, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan.
EM m3_514@yahoo.co.jp
RI Morisaki, Akimasa/ADI-0738-2022
OI Morisaki, Akimasa/0000-0001-9736-5257
CR Bath MF, 2021, J HOSP INFECT, V118, P32, DOI 10.1016/j.jhin.2021.08.021
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   Ikeno Y, 2019, EUR J CARDIO-THORAC, V55, P975, DOI 10.1093/ejcts/ezy389
   Kreibich M, 2018, ANN THORAC SURG, V106, P498, DOI 10.1016/j.athoracsur.2018.03.012
   Kuriyama M, 2018, J PLAST RECONSTR AES, V71, P699, DOI 10.1016/j.bjps.2018.02.004
   Molina JE, 2006, J THORAC CARDIOV SUR, V132, P782, DOI 10.1016/j.jtcvs.2006.06.008
   Morgan D, 2000, Ostomy Wound Manage, V46, P44
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   Morotomi N, 2010, ANN THORAC CARDIOVAS, V16, P9
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
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   Takano T, 2014, ANN THORAC CARDIOVAS, V20, P304, DOI 10.5761/atcs.oa.13-00059
   Tarzia V, 2014, INTERACT CARDIOV TH, V19, P70, DOI 10.1093/icvts/ivu101
   Umminger J, 2016, EUR J CARDIO-THORAC, V50, P660, DOI 10.1093/ejcts/ezw150
   Yamanaka K, 2014, EUR J CARDIO-THORAC, V46, P974, DOI 10.1093/ejcts/ezu119
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NR 20
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD SEP
PY 2022
VL 37
IS 9
BP 2745
EP 2746
DI 10.1111/jocs.16700
EA JUN 2022
PG 2
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 3L1EM
UT WOS:000813626300001
PM 35726652
DA 2026-07-24
ER

PT J
AU Woods, S
   Marques, AID
   Renwick, MG
   Argyle, SA
   Yool, DA
AF Woods, Samantha
   Marques, Ana I. de Castro
   Renwick, Mala G.
   Argyle, Sally A.
   Yool, Donald A.
TI Nanocrystalline silver dressing and subatmospheric pressure therapy
   following neoadjuvant radiation therapy and surgical excision of a
   feline injection site sarcoma
SO JOURNAL OF FELINE MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CLOSURE
AB Clinical summary This is the first clinical report of use of a combination of nanocrystalline silver and subatmospheric pressure therapy to treat a resistant wound infection, following tumour removal and radiation therapy, in a difficult-to-manage surgical site in a cat.
   Practical relevance The therapy was well tolerated and the authors suggest it is a valid treatment protocol for management of non-healing or infected wounds in the cat.
C1 [Woods, Samantha; Marques, Ana I. de Castro; Renwick, Mala G.; Argyle, Sally A.; Yool, Donald A.] Univ Edinburgh, Div Vet Clin Sci, Royal Dick Sch Vet Studies, Easter Bush Vet Ctr,Hosp Small Anim, Roslin EH25 9RG, Midlothian, Scotland.
C3 University of Edinburgh
RP Woods, S (通讯作者)，Univ Edinburgh, Div Vet Clin Sci, Royal Dick Sch Vet Studies, Easter Bush Vet Ctr,Hosp Small Anim, Roslin EH25 9RG, Midlothian, Scotland.
EM samantha.woods@ed.ac.uk
RI Woods, Samantha/MFI-5154-2025; Yool, Donald/PKQ-5683-2026; Renwick,
   Mala/HNQ-7074-2023
OI Woods, Samantha/0009-0003-8265-5819; Yool, Donald/0000-0002-3562-9111; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Argyle DJ., 2008, Decision making in Small Animal Oncology
   Ben-Amotz R, 2007, VET SURG, V36, P684, DOI 10.1111/j.1532-950X.2007.00321.x
   Bickels J, 2005, CLIN ORTHOP RELAT R, P346, DOI 10.1097/01.blo.0000180450.21350.3e
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   Karakousis CP, 2010, J SURG ONCOL, V101, P730, DOI 10.1002/jso.21563
   Kirkby K.A., 2010, Compedium: Continuing Education for Veterinarians, V32, P1
   Lafortune M, 2007, J ZOO WILDLIFE MED, V38, P341, DOI 10.1638/1042-7260(2007)038[0341:WMIAJT]2.0.CO;2
   Lansdown A B G, 2002, J Wound Care, V11, P173
   Lansdown A B G, 2002, J Wound Care, V11, P125
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   Owen LJ, 2009, VET COMP ORTHOPAED, V22, P417, DOI 10.3415/VCOT-08-12-0123
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schimp VL, 2004, GYNECOL ONCOL, V92, P586, DOI 10.1016/j.ygyno.2003.10.055
   Siegel HJ, 2007, J SURG ONCOL, V96, P575, DOI 10.1002/jso.20846
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NR 24
TC 6
Z9 7
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1098-612X
EI 1532-2750
J9 J FELINE MED SURG
JI J. Feline Med. Surg.
PD MAR
PY 2012
VL 14
IS 3
BP 214
EP 218
DI 10.1177/1098612X12439269
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 962FL
UT WOS:000305526800006
PM 22370864
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER

PT J
AU Caianiello, G
   Petraio, A
   Ursomando, F
   Pepino, P
   Cotrufo, M
   De Feo, M
   Maiello, C
   De Santo, LS
AF Caianiello, Giuseppe
   Petraio, Andrea
   Ursomando, Fabio
   Pepino, Paolo
   Cotrufo, Maurizio
   De Feo, Marisa
   Maiello, Ciro
   De Santo, Luca S.
TI Aortic Erosion During Negative Pressure Therapy in a Pediatric Heart
   Transplant Recipient
SO ANNALS OF THORACIC SURGERY
LA English
DT Editorial Material
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; INFECTIONS
AB A happy-ending "series of unfortunate events" is reported of the successful emergency treatment of an erosion of the ascending aorta during negative pressure sternal wound therapy for a relapse of Berlin Heart driveline infection in a pediatric transplant recipient. Several key issues related to assist device-related infections and negative pressure complications are discussed in this peculiar setting. (Ann Thorac Surg 2011; 92: 1879-80) (C) 2011 by The Society of Thoracic Surgeons
C1 [De Santo, Luca S.] V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, I-80131 Naples, Italy.
   Pineta Grande Hosp, Dept Cardiovasc Surg, Naples, Italy.
RP De Santo, LS (通讯作者)，V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Via L Bianchi 5, I-80131 Naples, Italy.
EM luca.desanto@ospedalemonaldi.it
RI DE SANTO, LUCA SALVATORE/AAJ-2231-2020; Maiello, Ciro/IAR-5127-2023
OI DE SANTO, LUCA SALVATORE/0000-0002-8958-9063; Maiello,
   Ciro/0000-0003-1604-4756
CR Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
   Gordon RJ, 2006, LANCET INFECT DIS, V6, P426, DOI 10.1016/S1473-3099(06)70522-9
   Grauhan O, 2010, INTERACT CARDIOV TH, V11, P493, DOI 10.1510/icvts.2010.238105
   Kouretas PC, 2009, ARTIF ORGANS, V33, P922, DOI 10.1111/j.1525-1594.2009.00950.x
   Petzina R, 2010, J THORAC CARDIOV SUR, V140, P1133, DOI 10.1016/j.jtcvs.2010.06.063
   Yuh DD, 2005, ANN THORAC SURG, V80, P1493, DOI 10.1016/j.athoracsur.2004.03.043
NR 6
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2011
VL 92
IS 5
BP 1879
EP 1880
DI 10.1016/j.athoracsur.2011.04.092
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 846TF
UT WOS:000296925400072
PM 22051284
OA Bronze
DA 2026-07-24
ER

PT J
AU Tokuda, Y
   Teranishi, K
   Morita, S
   Yamaguchi, K
   Takeuchi, E
AF Tokuda, Yoshiyuki
   Teranishi, Katsuhito
   Morita, Shin
   Yamaguchi, Kazuo
   Takeuchi, Eiji
TI Pneumopericardial Tamponade in a Patient With Partial Sternal Dehiscence
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID CARDIAC-TAMPONADE
AB We present a rare case of sudden pneumopericardial tamponade in a patient with partial sternal dehiscence after cardiac surgery. Urgent decompression was needed in the management of the condition. Vacuum-assisted closure therapy was also used to prevent the problem from recurring. When there is acute hemodynamic deterioration in a patient with sternal wound dehiscence, pneumopericardial tamponade should be considered as a possible complication. (Ann Thorac Surg 2010;89:1291-2) (C) 2010 by The Society of Thoracic Surgeons
C1 [Tokuda, Yoshiyuki; Teranishi, Katsuhito; Morita, Shin; Yamaguchi, Kazuo; Takeuchi, Eiji] Natl Hosp Org, Nagoya Med Ctr, Dept Cardiovasc Surg, Naka Ku, Aichi 4600001, Japan.
C3 Nagoya Medical Center
RP Tokuda, Y (通讯作者)，Natl Hosp Org, Nagoya Med Ctr, Dept Cardiovasc Surg, Naka Ku, 4-1-1 Sannomaru, Aichi 4600001, Japan.
EM tokuda@mxb.mesh.ne.jp
RI Tokuda, Yoshiyuki/B-8432-2016; Takeuchi, Eiji/ABC-6741-2021
OI Tokuda, Yoshiyuki/0000-0001-6405-8752; 
CR Benedík J, 2002, EUR J CARDIO-THORAC, V21, P585, DOI 10.1016/S1010-7940(01)01159-9
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NR 6
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD APR
PY 2010
VL 89
IS 4
BP 1291
EP 1292
DI 10.1016/j.athoracsur.2009.09.022
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 573CK
UT WOS:000275885800053
PM 20338363
OA Bronze
DA 2026-07-24
ER

PT J
AU Bergeron, EJ
   Meguid, RA
   Mitchell, JD
AF Bergeron, Edward J.
   Meguid, Robert A.
   Mitchell, John D.
TI Chronic infections of the Chest Wall
SO THORACIC SURGERY CLINICS
LA English
DT Article
DE Infection; Chest wall; Osteomyelitis; Sternoclavicular joint;
   Tuberculosis; Granuloma
ID VACUUM-ASSISTED CLOSURE; SURGICAL-MANAGEMENT; SEPTIC ARTHRITIS;
   TUBERCULOSIS; WOUNDS
AB Chronic chest wall infections may occur in soft tissue, cartilage, and bone. They may present as localized chest wall pain, a discrete mass initially mistaken for neoplasm, a superficial infection, or a draining sinus. Chronic chest wall infections are typically non-necrotizing and associated with lower morbidity than their more acute and necrotizing counterparts. Effective management of chest wall infections ranges from antimicrobial administration to wide surgical resection and subsequent reconstruction.
C1 [Bergeron, Edward J.; Meguid, Robert A.; Mitchell, John D.] Univ Colorado, Dept Surg, Div Cardiothorac Surg, Anschutz Med Campus,12631 East 17th Ave,C-310, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz
RP Bergeron, EJ (通讯作者)，Univ Colorado, Dept Surg, Div Cardiothorac Surg, Anschutz Med Campus,12631 East 17th Ave,C-310, Aurora, CO 80045 USA.
EM Edward.Bergeron@ucdenver.edu
OI Meguid, Robert/0000-0003-2646-4252
CR Abu Arab W, 2011, EUR J CARDIO-THORAC, V40, P630, DOI 10.1016/j.ejcts.2010.12.037
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   Bryan CS, 2013, TEX HEART I J, V40, P125
   Burkhart HM, 2003, J THORAC CARDIOV SUR, V125, P945, DOI 10.1067/mtc.2003.172
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   Condos R, 2000, INT J TUBERC LUNG D, V4, pS11
   Dada-Adegbola Hannah O, 2005, West Afr J Med, V24, P346
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   Garg V, 2014, NEUROSURG FOCUS, V37, DOI 10.3171/2014.6.FOCUS14134
   Gür A, 2003, YONSEI MED J, V44, P33, DOI 10.3349/ymj.2003.44.1.33
   Kevric I, 2015, DERMATOL CLIN, V33, P579, DOI 10.1016/j.det.2015.03.018
   Lim SY, 2010, ANN PLAS SURG, V64, P302, DOI 10.1097/SAP.0b013e3181b0bb03
   Mabeza GF, 2003, EUR RESPIR J, V21, P545, DOI 10.1183/09031936.03.00089103
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Ross JJ, 2004, MEDICINE, V83, P139, DOI 10.1097/01.md.0000126761.83417.29
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Siegel HJ, 2007, J SURG ONCOL, V96, P575, DOI 10.1002/jso.20846
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   SMITH JW, 1995, CLIN INFECT DIS, V20, P225, DOI 10.1093/clinids/20.2.225
   Song HK, 2002, ANN THORAC SURG, V73, P427, DOI 10.1016/S0003-4975(01)03390-2
   Steinmetz S, 2014, J ANTIMICROB CHEMOTH, V69, P821, DOI 10.1093/jac/dkt429
   Welvaart Willem N, 2009, Interact Cardiovasc Thorac Surg, V8, P558, DOI 10.1510/icvts.2008.196485
NR 30
TC 12
Z9 18
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1547-4127
J9 THORAC SURG CLIN
JI Thorac. Surg. Clin.
PD MAY
PY 2017
VL 27
IS 2
BP 87
EP +
DI 10.1016/j.thorsurg.2017.01.002
PG 12
WC Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System; Surgery
GA ET6QE
UT WOS:000400415700003
PM 28363377
DA 2026-07-24
ER

PT J
AU Gilmour, E
   Stewart, DG
AF Gilmour, E
   Stewart, DG
TI Severe recalcitrant pyoderma gangrenosum responding to a combination of
   mycophenolate mofetil with cyclosporin and complicated by a mononeuritis
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
DE mononeuritis; mycophenolate mofetil; negative pressure dressing;
   pyoderma gangrenosum
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; TACROLIMUS
AB We describe a 17-year-old boy with severe recalcitrant pyoderma gangrenosum. Healing was achieved with a combination of mycophenolate mofetil and cyclosporin, negative pressure dressings and split-skin grafts. His recovery was complicated by a sciatic nerve palsy, which we believe was caused by direct involvement of the nerve at the level of the sciatic notch.
C1 Univ Hosp Birmingham NHS Trust, Dept Dermatol, Birmingham B29 6JD, W Midlands, England.
RP Gilmour, E (通讯作者)，Univ Hosp Birmingham NHS Trust, Dept Dermatol, Raddlebarn Rd, Birmingham B29 6JD, W Midlands, England.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brunsting LA, 1930, ARCH DERMATOL SYPH, V22, P655, DOI 10.1001/archderm.1930.01440160053009
   Cooley HM, 1996, AUST NZ J MED, V26, P238, DOI 10.1111/j.1445-5994.1996.tb00896.x
   CURLEY RK, 1985, BRIT J DERMATOL, V113, P601, DOI 10.1111/j.1365-2133.1985.tb02385.x
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   Hohenleutner U, 1997, LANCET, V350, P1748, DOI 10.1016/S0140-6736(05)63571-4
   Lyon CC, 1999, BRIT J DERMATOL, V140, P562
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nousari HC, 1998, ARCH DERMATOL, V134, P1509, DOI 10.1001/archderm.134.12.1509
   Schuppe HC, 1998, LANCET, V351, P832, DOI 10.1016/S0140-6736(05)78962-5
   1997, DRUG THER B, V35, P38
NR 11
TC 25
Z9 27
U1 0
U2 0
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0007-0963
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD FEB
PY 2001
VL 144
IS 2
BP 397
EP 400
DI 10.1046/j.1365-2133.2001.04036.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 406VJ
UT WOS:000167236600033
PM 11251582
DA 2026-07-24
ER

PT J
AU Pape, HC
   Webb, LX
AF Pape, Hans-Christoph
   Webb, Lawrence X.
TI History of Open Wound and Fracture Treatment
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open wounds; fracture treatment; VAC; VAC Therapy
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB This introduction summarizes historical aspects regarding improvements in the treatment of open fractures and complicated wounds. Before the development of standardized surgical wound treatment and antisepsis, amputations were frequently required to prevent sepsis and death. Nowadays, the use of modern scaling techniques has caused a further dramatic reduction in the infection rates and an improvement of the healing response, thus enabling orthopaedic surgeons to perform skin graft coverage, where previously plastic surgeons had to perform skin flaps.
C1 [Pape, Hans-Christoph] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA.
   [Webb, Lawrence X.] Wake Forest Univ, Bowman Gray Sch Med, Dept Orthopaed Surg, Winston Salem, NC USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Wake Forest University; Wake Forest Baptist Medical
   Center
RP Pape, HC (通讯作者)，Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Kaufmann Med Bldg,3471 5th Ave,Suite 1010, Pittsburgh, PA 15213 USA.
EM papehc@upmc.edu
OI Pape, Hans-Christoph/0000-0002-2059-4980
CR Aronson J, 1997, J BONE JOINT SURG AM, V79A, P1243, DOI 10.2106/00004623-199708000-00019
   Bhattacharyya T, 2008, PLAST RECONSTR SURG, V121, P1263, DOI 10.1097/01.prs.0000305536.09242.a6
   BRUMBACK RJ, 1989, LOWER EXTREMITY SALV, P71
   CRUSE PJE, 1988, SURGICAL INFECTIOUS, P319
   Lee LF, 2008, PLAST RECONSTR SURG, V121, P1256, DOI 10.1097/01.prs.0000304237.54236.66
   Leininger BE, 2006, J TRAUMA, V61, P1207, DOI 10.1097/01.ta.0000241150.15342.da
   Li Xue-yong, 2007, Zhonghua Shao Shang Za Zhi, V23, P292
   Morykwas MJ, 1999, J BURN CARE REHABIL, V20, P15, DOI 10.1097/00004630-199901001-00003
   Norbury K, 2007, WOUNDS, V19, P97
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   STEIERT AE, 2008, J PLAST RECONST 0324
   Wangensteen OwenH., 1978, RISE SURG EMPIRIC CR
   Webb Lawrence X, 2006, J Am Acad Orthop Surg, V14, pS82
NR 13
TC 17
Z9 26
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S133
EP S134
DI 10.1097/BOT.0b013e318188e26b
PG 2
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100002
PM 19034158
DA 2026-07-24
ER

PT J
AU Tian, M
   Wang, XQ
   Xiao, YR
   Lu, SL
   Jiang, YZ
AF Tian, Ming
   Wang, Xiqiao
   Xiao, Yurui
   Lu, Shuliang
   Jiang, Yuzhi
TI A Successful Rescue of Systematic Inflammatory Response Syndrome
   Resulting From Severe Wound Infection
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE systematic inflammatory response syndrome; SIRS; debridement; topical
   negative pressure; antibiotics; local wound infection
ID VACUUM-ASSISTED CLOSURE; THERAPY; MULTICENTER
AB This article reports a critical case of systematic inflammatory response syndrome (SIRS) due to wound infection. By intensive local wound treatment including debridement, topical negative pressure, and topical antibiotics, SIRS was effectively controlled, vital signs stabilized, and the wound healed in 45 days. This case reflects the close association between wound infection and SIRS while highlighting early diagnosis of local pathology and local treatment.
C1 [Tian, Ming; Wang, Xiqiao; Xiao, Yurui; Lu, Shuliang; Jiang, Yuzhi] Shanghai Jiao Tong Univ, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University
RP Jiang, YZ (通讯作者)，Shanghai Jiao Tong Univ, Dept Trauma Repair, Shanghai Burns Inst, Ruijin Hosp,Sch Med, Shanghai 200025, Peoples R China.
EM yuzhijiang.med@gmail.com
OI Tian, Ming/0000-0003-1665-321X
FU key projects in the National Science & Technology Pillar Program
   [2012BAI11B04]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   authors are supported by key projects in the National Science &
   Technology Pillar Program (2012BAI11B04).
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NR 10
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 152
EP 154
DI 10.1177/1534734612456395
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010EX
UT WOS:000309078600004
PM 22885608
DA 2026-07-24
ER

PT J
AU Pena-Robichaux, V
   Goldberg, S
AF Pena-Robichaux, Venessa
   Goldberg, Stephanie
TI Procedural treatments for hidradenitis suppurativa
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE deroofing surgery; excisional surgery; hidradenitis suppurativa; laser.
ID INTRALESIONAL PHOTODYNAMIC THERAPY; TISSUE-SPARING EXCISION;
   VACUUM-ASSISTED CLOSURE; DIOXIDE LASER EXCISION; SURGICAL-TREATMENT;
   AXILLARY HIDRADENITIS; AMINOLEVULINIC ACID; RETROSPECTIVE ANALYSIS;
   5-AMINOLEVULINIC ACID; TREATMENT OPTION
AB Procedural treatments for hidradenitis suppurativa play a pivotal role in management of patients with hidradenitis suppurativa when used in combination with medical therapy. Laser, light, and surgical procedures can be used to improve a patient's symptoms and quality of life. Understanding how and when to use these treatments effectively is important for long-term hidradenitis suppurativa management.
C1 [Pena-Robichaux, Venessa] Univ Texas Austin, Dell Med Sch, Div Dermatol, 313 E 12th St Suite 101, Austin, TX 78701 USA.
   [Pena-Robichaux, Venessa] Cent Texas Vet Healthcare Syst, Med Serv, Sect Dermatol, Austin, TX USA.
   Mary Washington Healthcare, Dept Surg, Fredericksburg, VA USA.
C3 University of Texas System; University of Texas Austin
RP Pena-Robichaux, V (通讯作者)，Univ Texas Austin, Dell Med Sch, Div Dermatol, 313 E 12th St Suite 101, Austin, TX 78701 USA.
EM venessa.penarobichaux@ascension.org
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NR 102
TC 1
Z9 1
U1 1
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD DEC
PY 2024
VL 91
IS 6
BP S46
EP S51
DI 10.1016/j.jaad.2024.08.072
EA DEC 2024
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA P0P3C
UT WOS:001375033600008
PM 39627000
DA 2026-07-24
ER

PT J
AU Kirkpatrick, AW
   Roberts, DJ
   De Waele, J
   Jaeschke, R
   Malbrain, MLNG
   De Keulenaer, B
   Duchesne, J
   Bjorck, M
   Leppaniemi, A
   Ejike, JC
   Sugrue, M
   Cheatham, M
   Ivatury, R
   Ball, CG
   Blaser, AR
   Regli, A
   Balogh, ZJ
   D'Amours, S
   Debergh, D
   Kaplan, M
   Kimball, E
   Olvera, C
AF Kirkpatrick, Andrew W.
   Roberts, Derek J.
   De Waele, Jan
   Jaeschke, Roman
   Malbrain, Manu L. N. G.
   De Keulenaer, Bart
   Duchesne, Juan
   Bjorck, Martin
   Leppaniemi, Ari
   Ejike, Janeth C.
   Sugrue, Michael
   Cheatham, Michael
   Ivatury, Rao
   Ball, Chad G.
   Blaser, Annika Reintam
   Regli, Adrian
   Balogh, Zsolt J.
   D'Amours, Scott
   Debergh, Dieter
   Kaplan, Mark
   Kimball, Edward
   Olvera, Claudia
CA Pediat Guidelines Sub-Comm World
TI Intra-abdominal hypertension and the abdominal compartment syndrome:
   updated consensus definitions and clinical practice guidelines from the
   World Society of the Abdominal Compartment Syndrome
SO INTENSIVE CARE MEDICINE
LA English
DT Article
DE Intra-abdominal hypertension; Abdominal compartment syndrome; Critical
   care; Grading of Recommendations; Assessment, Development, and
   Evaluation; Evidence-based medicine; World Society of the Abdominal
   Compartment Syndrome
ID DAMAGE CONTROL RESUSCITATION; VACUUM-ASSISTED CLOSURE; CRITICALLY-ILL
   PATIENTS; OPEN ABDOMEN; INTERNATIONAL-CONFERENCE; PRESSURE MEASUREMENT;
   FASCIAL CLOSURE; VENTRAL HERNIA; RISK-FACTORS; MANAGEMENT
AB To update the World Society of the Abdominal Compartment Syndrome (WSACS) consensus definitions and management statements relating to intra-abdominal hypertension (IAH) and the abdominal compartment syndrome (ACS).
   We conducted systematic or structured reviews to identify relevant studies relating to IAH or ACS. Updated consensus definitions and management statements were then derived using a modified Delphi method and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidelines, respectively. Quality of evidence was graded from high (A) to very low (D) and management statements from strong RECOMMENDATIONS (desirable effects clearly outweigh potential undesirable ones) to weaker SUGGESTIONS (potential risks and benefits of the intervention are less clear).
   In addition to reviewing the consensus definitions proposed in 2006, the WSACS defined the open abdomen, lateralization of the abdominal musculature, polycompartment syndrome, and abdominal compliance, and proposed an open abdomen classification system. RECOMMENDATIONS included intra-abdominal pressure (IAP) measurement, avoidance of sustained IAH, protocolized IAP monitoring and management, decompressive laparotomy for overt ACS, and negative pressure wound therapy and efforts to achieve same-hospital-stay fascial closure among patients with an open abdomen. SUGGESTIONS included use of medical therapies and percutaneous catheter drainage for treatment of IAH/ACS, considering the association between body position and IAP, attempts to avoid a positive fluid balance after initial patient resuscitation, use of enhanced ratios of plasma to red blood cells and prophylactic open abdominal strategies, and avoidance of routine early biologic mesh use among patients with open abdominal wounds. NO RECOMMENDATIONS were possible regarding monitoring of abdominal perfusion pressure or the use of diuretics, renal replacement therapies, albumin, or acute component-parts separation.
   Although IAH and ACS are common and frequently associated with poor outcomes, the overall quality of evidence available to guide development of RECOMMENDATIONS was generally low. Appropriately designed intervention trials are urgently needed for patients with IAH and ACS.
C1 [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB T2N 2T9, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Crit Care Med, Calgary, AB T2N 2T9, Canada.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.] Univ Calgary, Dept Surg, Calgary, AB T2N 5A1, Canada.
   [Roberts, Derek J.] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 5A1, Canada.
   [De Waele, Jan] Ghent Univ Hosp, Dept Crit Care Med, Ghent, Belgium.
   [De Waele, Jan] Ghent Med Sch, Ghent, Belgium.
   [Jaeschke, Roman] McMaster Univ, Dept Med, Hamilton, ON L8P 3B6, Canada.
   [Jaeschke, Roman] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8P 3B6, Canada.
   [Malbrain, Manu L. N. G.] Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, Intens Care Unit, B-2060 Antwerp 6, Belgium.
   [Malbrain, Manu L. N. G.] Ziekenhuis Netwerk Antwerpen, ZNA Stuivenberg, High Care Burn Unit, B-2060 Antwerp 6, Belgium.
   [De Keulenaer, Bart; Regli, Adrian] Fremantle Hosp, Intens Care Unit, Fremantle, WA 6959, Australia.
   [Duchesne, Juan] Tulane Surg Intens Care Unit, Div Surg Anesthesia & Emergency Med, Sect Trauma & Crit Care Surg, New Orleans, LA 70112 USA.
   [Bjorck, Martin] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
   [Leppaniemi, Ari] Univ Helsinki, Meilahti Hosp, Dept Abdominal Surg, Helsinki 00029, Finland.
   [Ejike, Janeth C.] Loma Linda Univ Childrens Hosp, Loma Linda, CA USA.
   [Sugrue, Michael] Letterkenny Hosp, Donegal, Ireland.
   [Sugrue, Michael] Donegal Clin Res Acad, Donegal, Ireland.
   [Sugrue, Michael] Univ Coll Hosp, Galway, Ireland.
   [Cheatham, Michael] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL 32806 USA.
   [Ivatury, Rao] Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA.
   [Ball, Chad G.] EG 23 Foothills Med Ctr, Reg Trauma Serv, Calgary, AB T2N 2T9, Canada.
   [Blaser, Annika Reintam] Univ Tartu, Clin Anaesthesiol & Intens Care, EE-51014 Tartu, Estonia.
   [Regli, Adrian] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA 6009, Australia.
   [Regli, Adrian] Univ Notre Dame, Sch Med, Fremantle, WA 6959, Australia.
   [Balogh, Zsolt J.] Univ Newcastle, John Hunter Hosp, Newcastle, NSW 2310, Australia.
   [D'Amours, Scott] Liverpool Hosp, Trauma Dept, Liverpool, Nsw Bc 2170, Australia.
   [Debergh, Dieter] Ghent Univ Hosp, Dept Intens Care, B-9000 Ghent, Belgium.
   [Kaplan, Mark] Albert Einstein Med Ctr, Philadelphia, PA 19141 USA.
   [Kimball, Edward] Univ Utah, Dept Surg, Salt Lake City, UT USA.
   [Olvera, Claudia] Univ Anahuac, Amer British Cowdray Med Ctr, Mexico City, DF, Mexico.
C3 University of Calgary; University Calgary Hospital; University of
   Calgary; University Calgary Hospital; University of Calgary; University
   Calgary Hospital; University of Calgary; University of Calgary; Ghent
   University; Ghent University Hospital; Ghent University; McMaster
   University; McMaster University; ZNA Stuivenberg; ZNA Stuivenberg; South
   Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group;
   Fremantle Hospital; University of Western Australia; Tulane University;
   Uppsala University; University of Helsinki; Helsinki University Central
   Hospital; Loma Linda University; Ollscoil na Gaillimhe-University of
   Galway; Orlando Health; Orlando Regional Medical Center; Virginia
   Commonwealth University; University of Tartu; University of Western
   Australia; The University of Notre Dame Australia; John Hunter Hospital;
   University of Newcastle; Liverpool Hospital; Ghent University; Ghent
   University Hospital; Yeshiva University; Utah System of Higher
   Education; University of Utah; Universidad Anahuac
RP Kirkpatrick, AW (通讯作者)，Foothills Med Ctr, Dept Surg, Calgary, AB T2N 2T9, Canada.
EM Andrew.kirkpatrick@albertahealthservices.ca; Derek.Roberts01@gmail.com;
   jan.dewaele@UGent.be; jaeschke@mcmaster.ca; manu.malbrain@skynet.be;
   bdekeul@hotmail.com; jduchesn@tulane.edu; martin@bjorck.pp.se;
   ari.leppaniemi@hus.fi; jejike@llu.edu; acstrauma@hotmail.com;
   Michael.cheatham@orlandohealth.com; rivatury@mcvh-vcu.edu;
   ball.chad@gmail.com; annika.reintam.blaser@ut.ee;
   Adrian.regli@gmail.com; Zsolt.balogh@hne.health.nsw.gov.au;
   Scott.Damours@swsahs.nsw.gov.au; dieter.debergh@UGent.be;
   kaplanm@einstein.edu; Edward.kimball@hsc.utah.edu; claudia_olvera@me.com
RI De Waele, Jan/E-2704-2013; Roberts, Derek/L-6229-2019; Malbrain,
   Manu/B-3680-2017; Leppäniemi, Ari/GQZ-7991-2022; Ivatury,
   Rao/H-2922-2019; Balogh, Zsolt/A-2002-2010; Jaeschke,
   Roman/ABW-5103-2022; Bjorck, Martin/A-4104-2008; Reintam Blaser,
   Annika/M-1573-2013
OI De Waele, Jan/0000-0003-1017-9748; D'Amours, Scott/0009-0004-4975-7984;
   Roberts, Derek/0000-0001-6111-6291; Regli, Adrian/0000-0002-3960-6013;
   Malbrain, Manu/0000-0002-1816-5255; Reintam Blaser,
   Annika/0000-0003-1211-7372
FU Alberta Innovates-Health Solutions Clinician Fellowship Award; Clinician
   Investigator Program at the University of Calgary; World Society of the
   Abdominal Compartment Syndrome
FX Dr. Roberts is supported by an Alberta Innovates-Health Solutions
   Clinician Fellowship Award and funding from the Clinician Investigator
   Program at the University of Calgary. We thank Gordon Guyatt, MD, MSc,
   Department of Medicine, McMaster University, Hamilton, Ontario, Canada
   L8P 3B6, Department of Clinical Epidemiology and Biostatistics, McMaster
   University for methodological guidance. We also thank Ms. Michelle
   Mercado and Ms. Alma Rados of the Trauma Association of Canada for
   web-hosting and editing. This manuscript was commissioned and supported
   by the World Society of the Abdominal Compartment Syndrome
   (www.wsacs.org).
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NR 96
TC 1033
Z9 1374
U1 3
U2 97
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0342-4642
EI 1432-1238
J9 INTENS CARE MED
JI Intensive Care Med.
PD JUL
PY 2013
VL 39
IS 7
BP 1190
EP 1206
DI 10.1007/s00134-013-2906-z
PG 17
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 163KF
UT WOS:000320334100003
PM 23673399
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Willms, AG
   Schaaf, S
   Zimmermann, N
   Schwab, R
   Güsgen, C
   Vilz, TO
   Kalff, JC
   von Websky, MW
AF Willms, Arnulf G.
   Schaaf, Sebastian
   Zimmermann, Nicolay
   Schwab, Robert
   Guesgen, Christoph
   Vilz, Tim O.
   Kalff, Joerg C.
   von Websky, Martin W.
TI The Significance of Visceral Protection in Preventing Enteroatmospheric
   Fistulae During Open Abdomen Treatment in Patients With Secondary
   Peritonitis A Propensity Score-matched Case-control Analysis
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal compartment syndrom; enteroatmospheric fistulae; negative
   pressure wound therapy; open abdomen; peritonitis; trauma
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; MEDIATED FASCIAL
   TRACTION; TEMPORARY ABDOMINAL CLOSURE; PROGNOSTIC-FACTORS; MANAGEMENT;
   CLASSIFICATION
AB Objective: To evaluate the influence of a visceral protective layer (VPL) on the formation of enteroatmospheric fistulae (EAF) in open abdomen treatment (OAT) for peritonitis. Background: EAF formation is a severe complication of OAT. Despite the widespread use of OAT, there are no robust evidence-based recommendations for preventing EAF. Methods: A total of 120 peritonitis patients with secondary peritonitis as a result of a perforation of a hollow viscus or anastomotic insufficiency who had undergone OAT were included, and 14 clinical parameters were recorded in prospective OAT databases at 2 tertiary referral centers. For this analysis, patients with a VPL were assigned to the treatment group and those without a VPL to the control group. Propensity Score (PS) matching was performed. Known risk factors in OAT such as malignant disease, mortality, emergency operation, OAT duration, and fascial closure were matching variables. The influence of VPL on EAF formation was statistically evaluated using logistic regression analysis. Results: With 34 patients in each group, no notable differences were identified with regard to age, sex, underlying disease, mortality, emergency operation, fascial closure, and OAT duration. Overall, a mortality rate of 22.1% for OAT due to peritonitis was observed. Mean OAT duration was approximately 9 days, and secondary fascial closure was achieved in more than two-thirds of all patients. Fascial traction was used in more than 75% of cases. EAF formation was significantly more frequent in the control group (EAF formation: VPL group 2.9% vs control 26.5%; P = 0.00). In the final regression analysis, the use of VPL resulted in a significant reduction in the risk of EAF formation (odds ratio 0.08; 95% confidence interval 0.01-0.71, P = 0.02), which translates to a relative risk reduction of 89.1%. Conclusion: VPL effectively prevents EAF formation during OAT in patients with peritonitis. We recommend the consistent use of VPL as part of a standardized OAT treatment algorithm.
C1 [Vilz, Tim O.; Kalff, Joerg C.; von Websky, Martin W.] Univ Hosp Bonn, Dept Surg, Bonn, Germany.
   [Willms, Arnulf G.; Schaaf, Sebastian; Zimmermann, Nicolay; Schwab, Robert; Guesgen, Christoph] German Armed Forces Cent Hosp, Dept Gen Visceral & Thorac Surg, Koblenz, Germany.
C3 University of Bonn
RP Willms, AG (通讯作者)，German Armed Forces Cent Hosp, Dept Gen Visceral & Thorac Surg, Koblenz, Germany.
EM ArnulfWillms@gmx.de
RI Willms, Arnulf/AFN-0812-2022; von Websky, Martin/AFC-6767-2022; Kalff,
   Joerg/U-8580-2017
OI Willms, Arnulf/0000-0001-9998-6735; 
CR Acosta S, 2016, EUR J VASC ENDOVASC, V51, P371, DOI 10.1016/j.ejvs.2015.10.014
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NR 28
TC 19
Z9 23
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2021
VL 273
IS 6
BP 1182
EP 1188
DI 10.1097/SLA.0000000000003440
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ST2UC
UT WOS:000662304000042
PM 31318792
DA 2026-07-24
ER

PT J
AU Ali, Z
   Anjum, A
   Khurshid, L
   Ahad, H
   Maajid, S
   Dhar, SA
AF Ali, Zameer
   Anjum, Afshan
   Khurshid, Lubna
   Ahad, Hamayun
   Maajid, Saheel
   Dhar, Shabir Ahmad
TI 被撤回的出版物: Evaluation of low-cost custom made VAC therapy compared with
   conventional wound dressings in the treatment of non-healing lower limb
   ulcers in lower socio-economic group patients of Kashmir valley
   (Retracted article. See vol. 12, art no 62, 2017)
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article; Retracted Publication
DE DFU; VAC; NPWT
ID NEGATIVE-PRESSURE; ASSISTED CLOSURE; FOOT; MULTICENTER
AB Background: Negative-pressure wound therapy is a technique to achieve wound healing in patients with non-healing wounds of the lower limb; vacuum-assisted closure (VAC) therapy is a technique to accelerate the healing of non-healing ulcers that fail to heal on their own (primary healing) (Plast Reconstr Surg 117:193-209S, 2006).
   Delayed wound healing or non-healing of ulcers is a significant health problem, particularly in older adults.
   The efficacy of VAC dressings has been demonstrated in several randomized controlled studies, which have shown significantly faster wound healing rates compared to conventional wound therapy (Lancet 366:1704-10, 2005; J Wound Care 17:426-32, 2008). However, commercially available VAC is costly.
   The aim of using custom made VAC was decided by our team due to lower socio-economic status of patients taken for study who could not have afforded charges of commercially available VAC unit.
   Objective: Objective was to evaluate VAC therapy compared with conventional dressings in the treatment of non-healing lower limb ulcers in lower socio-economic patients.
   Methods: Sixty patients of lower socio-economic status aged between 40 and 70 were prospectively studied for non-healing ulcers Wagner grade 2 or 3 and randomized into 2 groups. VAC dressing was kept for over a period of 2-7 weeks. Ulcers were treated until the wound closed spontaneously, surgically or until completion of the 50-day period, whichever was earlier.
   Results: By seventh week, discharge disappeared in 96 % in VAC and only 54 % in conventional dressing group. Granulation tissue appeared in 100 % of patients in VAC group and only 63 % in conventional dressing group. The patients treated with VAC dressing in our study showed comparable wound reduction capabilities with an average wound size reduction of 56 % in comparison to conventional dressing group which had average wound size reduction of 29 %.
   Majority of wounds in VAC group got closed in 7 weeks. Patient satisfaction was excellent in the majority of patients in VAC group compared to those in conventional dressing group.
   Conclusion: The application of VAC (TM) had shown good results in our study.
C1 [Ali, Zameer; Anjum, Afshan; Khurshid, Lubna; Ahad, Hamayun; Maajid, Saheel; Dhar, Shabir Ahmad] SKIMS Med Coll, Dept Orthopaed, Srinagar 190018, Jammu & Kashmir, India.
C3 Sher-i-Kashmir Institute of Medical Sciences
RP Ali, Z (通讯作者)，SKIMS Med Coll, Dept Orthopaed, Srinagar 190018, Jammu & Kashmir, India.
EM drzameeraliortho@gmail.com
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NR 16
TC 8
Z9 11
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC 10
PY 2015
VL 10
AR 183
DI 10.1186/s13018-015-0314-5
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CY3AE
UT WOS:000366278800001
PM 26654318
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, Y
   Zhao, YY
   Liu, SG
   Yao, ZH
   Jin, ZK
   Ma, WL
AF Zhang, Yang
   Zhao, Yangyang
   Liu, Shuanggong
   Yao, Zihan
   Jin, Zikang
   Ma, Wanli
TI A novel approach for managing the incisions of tibial plateau fractures
   with soft tissue swelling
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Tibial plateau fractures; Soft tissue damage; Incision management;
   Clinical efficiency
ID VACUUM-ASSISTED-CLOSURE; INTERNAL-FIXATION; EXTERNAL FIXATION; OPEN
   REDUCTION; THERAPY; MECHANISM
AB To investigate the feasibility and clinical efficacy of a novel approach to managing the incisions used to treat tibial plateau fractures (TPFs) with soft tissue swelling. We retrospectively enrolled 64 patients with TPFs who underwent surgery at the Second Hospital of Shandong University. Patients were divided into two groups: Group A (n = 32) underwent early surgery with the novel incision management technique, and Group B (n = 32) underwent conventional surgery after swelling reduction. The perioperative data of the two groups were compared, including the time from injury to surgery, one-stage operation time, intraoperative blood loss, number of dressing changes, wound healing time, and hospitalization time. Preoperative and postoperative complications were assessed in both groups, and pain condition, degree of arthritis, limb function, imaging results, and quality of life were evaluated using validated scales. The time from injury to surgery, number of dressing changes, and hospitalization time in Group A were significantly lower than those in Group B (P < 0.05). There were no significant differences in one-stage operation time, intraoperative blood loss, or wound healing time between the two groups (P > 0.05). There were fewer preoperative and postoperative complications in Group A than in Group B (P < 0.05). The VAS and WOMAC scores were reduced in both groups (P < 0.05); Group A had lower VAS scores two weeks after surgery. There was no statistically significant difference in the WOMAC score between the groups. The modified Rasmussen functional and radiological scores were elevated in both groups (P < 0.05). There was no statistically significant difference between the two groups for the modified Rasmussen functional or radiological score at any of the time points (P > 0.05). In addition, the two groups did not differ in quality of life (P > 0.05). For patients with tibial plateau fractures without congestive blisters, open reduction and internal fixation at the early stage of swelling and wide-spacing interrupted suture and negative pressure wound therapy (NPWT) closure of the wound could help obtain excellent to good functional outcomes with fewer complications. This novel incision management approach and concept expands the surgical indications for these fractures.
C1 [Zhang, Yang; Zhao, Yangyang; Liu, Shuanggong; Yao, Zihan; Ma, Wanli] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Orthopaed, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
   [Jin, Zikang] Linglong Yingcheng Hosp, Dept Orthopaed, Zhaoyuan 264000, Shandong, Peoples R China.
C3 Shandong University
RP Ma, WL (通讯作者)，Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Orthopaed, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
EM mawanli2000@email.sdu.edu.cn
RI yao, zihan/HCH-0912-2022
CR Adams JD Jr, 2020, ORTHOP CLIN N AM, V51, P471, DOI 10.1016/j.ocl.2020.06.003
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NR 43
TC 1
Z9 1
U1 1
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 21
PY 2025
VL 15
IS 1
AR 2683
DI 10.1038/s41598-025-86125-5
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T2A1D
UT WOS:001403090300008
PM 39837920
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ng, JWG
   Cairns, SA
   O'Boyle, CP
AF Ng, J. W. G.
   Cairns, S. A.
   O'Boyle, C. P.
TI Management of the lower gastrointestinal system in burn: A comprehensive
   review
SO BURNS
LA English
DT Review
DE Gastrointestinal effects; Burns; Pseudo-obstruction; Bacterial
   translocation; Abdominal compartment syndrome; Perineal burn
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; PERITONEAL
   RESUSCITATION INDICATIONS; ACUTE COLONIC PSEUDOOBSTRUCTION; PEDIATRIC
   PERIANAL BURNS; IMPROVING GRAFT-SURVIVAL; CONTROL OPEN CELIOTOMIES;
   DAMAGE CONTROL SURGERY; LINEA ALBA FASCIOTOMY; THICKNESS SKIN-GRAFTS
AB Background: Burn produces complex gastrointestinal (GI) responses. Treatment, including large volume fluid resuscitation and opioid analgesia, may exacerbate GI dysfunction. Complications include constipation and opioid-induced bowel dysfunction (OBD), acute colonic pseudo-obstruction (ACPO), bacterial translocation and sepsis, and abdominal compartment syndrome (ACS). Contamination of perineal burns contributes to delayed healing, skin graft failure and sepsis and may impact upon morbidity and mortality. The authors carried out a literature review on management of the lower GI system in burn. This study aimed to explain: current prevention and treatment modalities; drawbacks and complications associated with available treatments, and to provide direction for development of best practice guidelines. ACS is associated with high mortality and should be treated with careful fluid resuscitation and diuresis, to minimise and remove oedema.
   Methods: A comprehensive search of English language literature was performed on PubMed, Medline and Embase. Both MeSH and keywords searches were used.
   Results: Evidence available on the management of lower gastrointestinal system in burn is summarised. Levels of evidence available are generally low (level III-IV).
   Conclusion: Structured, graded interventions are required for prevention and treatment of constipation and OBD. Correction of electrolyte imbalance, adequate enteral intake and mobilisation are pre-requisites. Laxatives should be used according to World Gastroenterology Organisation recommendations. Resistant constipation may respond to changes in medication, but ACPO should be suspected and treated when present. Other complications, such as bacterial translocation and ACS are common in major burns. There is evidence that selective digestive tract decontamination reduces mortality and infectious episodes in major burns. ACS is associated with high mortality and should be treated with careful fluid resuscitation and diuresis. Surgery is reserved for non-responsive and severe cases. Perineal burns present challenges in wound and bowel management. Faecal management systems and negative pressure wound therapy (NPWT) may improve wound control and hygiene, but diversion colostomy will still be beneficial in some cases. There is a clear need for rigorous studies to guide practice more effectively in these challenging conditions. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Ng, J. W. G.; Cairns, S. A.; O'Boyle, C. P.] Nottingham Univ Hosp NHS Trust, Dept Plast Reconstruct & Burns Surg, City Campus, Nottingham NG5 1PB, England.
C3 Nottingham University Hospital NHS Trust; Nottingham City Hospital
RP Ng, JWG (通讯作者)，Nottingham Univ Hosp NHS Trust, Dept Plast Reconstruct & Burns Surg, City Hosp Campus,Hucknall Rd, Nottingham NG5 1PB, England.
EM jimmyng@nhs.net
RI ; /J-5853-2019
OI Ng, Jimmy/0000-0003-1827-9647; 
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NR 72
TC 14
Z9 18
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2016
VL 42
IS 4
BP 728
EP 737
DI 10.1016/j.burns.2015.08.007
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA DN2IC
UT WOS:000376886300012
PM 26774605
DA 2026-07-24
ER

PT J
AU Gong, J
   Sun, XH
   Fu, H
   Zhang, Y
   Gao, T
AF Gong, Juan
   Sun, Xiaohong
   Fu, Hong
   Zhang, Yu
   Gao, Ting
TI Comparative efficacy and safety of non-pharmacological nursing
   interventions for diabetic foot ulcers: a systematic review and network
   meta-analysis
SO BMC NURSING
LA English
DT Article
DE Diabetic foot ulcer; Non-pharmacological interventions; Nursing care;
   Network meta-analysis; Wound healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; SHOCK-WAVE THERAPY;
   VACUUM-ASSISTED CLOSURE; LEVEL LASER THERAPY; CONTROLLED-TRIAL;
   DOUBLE-BLIND; CONTINUOUS DIFFUSION; 2 MULTICENTER; STIMULATION
AB BackgroundNon-pharmacological nursing interventions are increasingly employed to enhance diabetic foot ulcer (DFU) healing and patient outcomes. However, the comparative effectiveness and safety profiles of various adjunctive nursing strategies remain unclear. This network meta-analysis systematically evaluated and ranked non-pharmacological nursing interventions for DFU management.MethodsA comprehensive systematic search was conducted in PubMed, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, and Web of Science from inception to March 31, 2025. Randomized controlled trials (RCTs) comparing non-pharmacological adjunctive nursing interventions (e.g., hyperbaric oxygen therapy [HBOT], light therapy [LT], ultrasound therapy [US], extracorporeal shock-wave therapy [ESWT], exercise therapy [EXER], continuous diffusion of oxygen [CDO], negative pressure wound therapy [NPWT]) with standard care or alternative interventions for DFU were included. Primary outcomes assessed were healing rate, healing time, wound area reduction, recurrence rate, amputation rate, and adverse events. Bayesian network meta-analysis was conducted using random-effects models, with results expressed as odds ratios (OR), standardized mean differences (SMD), and surface under cumulative ranking curves (SUCRA).ResultsSixty-seven RCTs involving 5957 patients were included. LT significantly increased healing rates compared with standard care (OR = 7.62; 95% CI, 2.92-19.90; SUCRA = 88.8%). US produced the largest wound area reduction (SMD = -3.17; 95% CI, -4.81 to -1.53; SUCRA = 98.4%). ESWT was superior in shortening healing time (SMD = -2.02; 95% CI, -3.33 to -0.71; SUCRA = 94.4%) and reducing amputation risk (OR = 0.40; 95% CI, 0.23-0.70). EXER significantly reduced recurrence rates (OR = 0.07; 95% CI, 0.02-0.33; SUCRA = 97.4%). CDO demonstrated the fewest adverse events (OR = 0.27; 95% CI, 0.08-0.85; SUCRA = 89.2%).ConclusionThis analysis provides targeted evidence for selecting adjunctive nursing interventions based on specific clinical goals. LT and US are optimal for enhancing wound closure and reducing wound area, ESWT is most effective for rapid healing and limb preservation, EXER excels at recurrence prevention, and CDO offers superior safety. These findings facilitate tailored nurse-led care plans and inform clinical guidelines.
C1 [Gong, Juan; Sun, Xiaohong; Zhang, Yu] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Hefei 230022, Anhui, Peoples R China.
   [Fu, Hong; Gao, Ting] Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Gao, T (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China.
EM 51583025@qq.com
RI Sun, Xiaohong/LGY-9610-2024
FU Research Funding for Doctoral Talents of the First Affiliated Hospital
   of Anhui Medical University [1952]
FX The research of our article was funded by Research Funding for Doctoral
   Talents of the First Affiliated Hospital of Anhui Medical University
   (Grant No.1952).
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NR 99
TC 0
Z9 0
U1 5
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6955
J9 BMC NURS
JI BMC Nurs.
PD NOV 26
PY 2025
VL 24
IS 1
AR 1445
DI 10.1186/s12912-025-04065-x
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA I4132
UT WOS:001626522700003
PM 41299407
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Scheer, HS
   Kaiser, M
   Zingg, U
AF Scheer, H. S.
   Kaiser, M.
   Zingg, U.
TI Results of directly applied activated carbon cloth in chronic wounds: a
   preliminary study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE activated carbon dressing; wound healing; Zorflexnurses
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; THERAPY; CARE; PREDICT; TRIAL
AB Objective: Activated carbon (AC) has been used in wound therapy as an active substance inside dressings. Applying AC directly on a wound is a new concept. The aim of this study was to analyse the outcomes of chronic wounds which were managed with directly applied activated carbon knitted cloth (ACC, Zorflex) in Swiss patients.
   Method: A retrospective analysis of the records of all patients with chronic wounds treated with ACC between 1 October 2013 and 31 December 2015 in an outpatient wound clinic. Chronic was defined as a wound being present for >3 weeks. Malignant wounds were excluded. The main outcome was the time to complete closure or readiness for spilt-thickness skin grafting (STSG). Descriptive data, including nutritional status and angiology results were obtained.
   Results: There were 36 women and 34 men, median age 68 years old. The median body mass index (BMI) 28.1kg/m(2) and 76% (n=53) of patients had comorbidities. Angiology exam results showed signs of reduced arterial perfusion in 13% (n=9) of patients and malnutrition in 11% (n=8). Of the wounds included 34% (n=24) were on the trunk and 66% (n=46) on the extremities. The median wound size was 6.9cm(2) (range: 0.1-300cm(2)). The wounds on the trunk were larger than wounds on extremities (10 versus 2cm(2)). Overall, median time to closure was 51 days. In 94% (n=66) of patients, wounds closed without further intervention and 6% (n=4) underwent STSG. Patients with comorbidities showed longer wound healing times compared with those without. No adverse events such as allergies or skin irritation occurred. Cost analysis, including personnel and material and stratified according known wound closure times, showed ACC (US$1252) to be like hydrocolloids (US$1128), but substantially lower than white gauze (US$3026) and negative pressure wound therapy (NPWT) (US$2578).
   Conclusion: ACC applied directly on chronic wounds of different aetiology is safe with short closure times. The cost efficiency is high. It combines the positive features of other wound dressings, such as hydrocolloids and NPWT, without their disadvantages. The dressing change of ACC is easy and non-specialised nurses or even patients themselves can be taught to perform it.
C1 [Scheer, H. S.; Kaiser, M.; Zingg, U.] Limmattal Hosp, Dept Surg, Zurich, Switzerland.
RP Zingg, U (通讯作者)，Limmattal Hosp, Dept Surg, Zurich, Switzerland.
EM urs.zingg@spital-limmattal.ch
OI Scheer, Helene Sophie/0000-0001-9124-573X
CR Anderson Kristin, 2012, J Am Coll Clin Wound Spec, V4, P84, DOI 10.1016/j.jccw.2014.03.001
   [Anonymous], 2006, Guidance for Industry: Chronic Cutaneous Ulcer and Burn Wounds-Developing Products for Treatment
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NR 27
TC 5
Z9 6
U1 0
U2 12
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2017
VL 26
IS 8
BP 476
EP 481
DI 10.12968/jowc.2017.26.8.476
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FD5AD
UT WOS:000407542400008
PM 28795884
DA 2026-07-24
ER

PT J
AU Sun, D
   Qin, Y
   Chen, YJ
   Ju, WN
   Qi, BC
AF Sun, Di
   Qin, Ying
   Chen, Yujia
   Ju, Weina
   Qi, Baochang
TI Iliopsoas abscess formation as a complication of abdominal stab wound: a
   case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Abdominal injuries; stab wound; iliopsoas abscess; vacuum drainage;
   antibiotic
AB Stab wounds are commonly encountered in clinical practice. However, iliopsoas abscess formation after an abdominal stab wound is relatively rare and its treatment is not well-documented. We report a case of a 20-year-old man who developed an iliopsoas abscess 10 days after an abdominal stab wound. In collaboration with orthopedic surgeons, wound debridement was performed twice, followed by vacuum sealing drainage (VSD), and implantation of antibiotic-loaded bone cement beads. Abdominal CT performed one month after surgery showed resolution of the abscess and acceptable recovery. No recurrence of symptoms was observed thereafter. Interdisciplinary collaboration is important for surgical treatment of complicated stab wounds. Use of VSD and implantation of antibiotic bead chain was found effective in treating the iliopsoas abscess.
C1 [Sun, Di] Jilin Univ, Hosp 1, Dept Colorectal & Anal Surg, Changchun, Jilin, Peoples R China.
   [Qin, Ying] Jilin Univ, Hosp 1, Dept Neurosurg, Changchun, Jilin, Peoples R China.
   [Chen, Yujia] Jilin Univ, Hosp 1, Dept Gen Surg, Changchun, Jilin, Peoples R China.
   [Ju, Weina] Jilin Univ, Hosp 1, Dept Neurol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
   [Qi, Baochang] Jilin Univ, Hosp 1, Dept Orthopaed Traumatol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University
RP Ju, WN (通讯作者)，Jilin Univ, Hosp 1, Dept Neurol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.; Qi, BC (通讯作者)，Jilin Univ, Hosp 1, Dept Orthopaed Traumatol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM erna198644@126.com; qibaochang1@163.com
RI chen, yujia/KJL-7313-2024
FU National Natural Science Foundation of China [81500911]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 81500911).
CR Biffl WL, 2011, J TRAUMA, V71, P1494, DOI 10.1097/TA.0b013e31823ba1de
   Eder Frank, 2011, Pol Przegl Chir, V83, P117, DOI 10.2478/v10035-011-0019-3
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   Posacioglu H, 2009, TEX HEART I J, V36, P65
NR 5
TC 0
Z9 0
U1 0
U2 13
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 12
BP 13933
EP 13935
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HF9FH
UT WOS:000454547200135
DA 2026-07-24
ER

PT J
AU Griffin, L
   Casillas, LL
AF Griffin, Leah
   Casillas, Laura Leyva
TI Evaluating the Impact of a Patient-centered Remote Monitoring Program on
   Adherence to Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE remote therapy monitoring; Negative Pressure Wound Therapy; patient
   adherence
AB A remote therapy monitoring (RTM) system has been developed for use with a negative pressure wound therapy (NPWT) unit for patients in the home care setting. In conjunction with RTM, a network of trained professionals call patients when their NPWT usage is low and provide education to assist with therapy adherence.
   Objective. The objective of this evaluation is to examine the relationship between the RTM system and patient adherence. Materials and Methods. One hundred ninety-eight home care patients receiving NPWT with RTM between December 2016 and April 2017 were included. Results. A total of 979 calls were made, with an average of 4.9 calls per patient. Among 198 patients, 195 received a welcome call, 157 received a call due to low adherence, and 35 had an escalation call made to their treating nurse. Of the 157 patients who required at least 1 call due to low adherence, 153 were successfully contacted at least once. The day following the patient call, adherence increased 73% of the time by an average of 8.5 hours. Conclusions. This evaluation suggests there is an ability to influence patient adherence through active engagement, potentially improving outcomes and reducing wound costs.
   The World Health Organization has estimated that 50% of those living with chronic illness are nonadherent to their prescribed therapy. 1 Estimates indicate that wounds account for nearly 4% of health care system costs, and that number is rising. 2 In an internal retrospective study of more than 1800 patients, increasing adherence to negative pressure wound therapy (NPWT) use has been shown to facilitate wound closure ( unpublished data, 2017). This led to a hypothesis that with active patient engagement, the rate of adherence to therapy could be affected. Recently, a proprietary remote therapy monitoring ( RTM) system (iOn PROGRESS Remote Therapy Monitoring; Acelity, San Antonio, TX) has been developed to provide timely feedback on patient adherence to wound management. The RTM system works in conjunction with a NPWT system (ACTIV.A.C. Therapy System; Acelity) to monitor patient compliance beyond the hospital setting. The objective of this evaluation is to examine the relationship between RTM and patient adherence to NPWT.
   MATERIALS AND METHODS This study included 198 patients receiving NPWT with RTM between December 2016 and April 2017. A connectivity module on the NPWT device enabled continuous RTM for patients receiving NPWT at home ( Figure 1). In conjunction with RTM, a network of trained professionals (iOn PROGRESS Care Network, Acelity) was available to contact patients and provide education to assist with therapy adherence. Patients with therapy usage < 16 hours in 1 day received an adherence call. Therapy usage leading up to and following the adherence call was measured using the RTM data. Failure to initially reach a patient or consistent noncompliance (ie, patient not reached following second adherence call within a 7-day period) triggered an escalation call to the patient's caregiver to discuss therapy adherence.
C1 [Griffin, Leah; Casillas, Laura Leyva] Acelity, 12930 West Interstate 10, San Antonio, TX 78249 USA.
RP Griffin, L (通讯作者)，Acelity, 12930 West Interstate 10, San Antonio, TX 78249 USA.
EM Leah.Griffin@kci1.com
FU Kinetic Concepts Inc, an Acelity Company, San Antonio, TX
FX Financial support for this research was provided by Kinetic Concepts
   Inc, an Acelity Company, San Antonio, TX. Mikaela Sifuentes, PhD,
   (Acelity) provided medical writing support.
CR Chisholm-Burns MA, 2012, J AM PHARM ASSOC, V52, P823, DOI 10.1331/JAPhA.2012.11088
   Drew Philip, 2007, Int Wound J, V4, P149, DOI 10.1111/j.1742-481X.2007.00337.x
NR 2
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2018
VL 30
IS 3
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GB3XQ
UT WOS:000428994200002
DA 2026-07-24
ER

PT J
AU Gao, Q
   Wei, YK
   Fan, XR
   Xu, WJ
   Gu, PF
   Liu, S
   Han, Y
AF Gao, Qiang
   Wei, Yukun
   Fan, Xiaorui
   Xu, Wenjian
   Gu, Pengfei
   Liu, Song
   Han, Yong
TI Delayed tracheal injury following total thyroidectomy: case report and
   literature review
SO BMC SURGERY
LA English
DT Review
DE Total thyroidectomy; Delayed tracheal injury; Tracheal injury;
   Subcutaneous emphysema
ID TRACHEOBRONCHIAL INJURIES
AB A 51-year-old woman developed extensive subcutaneous emphysema on postoperative day 7 following total thyroidectomy with central lymph node dissection for thyroid cancer, indicating delayed tracheal injury. Emergency surgery revealed rupture of inter-tracheal ring ligaments and connective tissue, resulting in a necrotic 3 x 2 cm wound with purulent exudate. Necrotic tissue was debrided until viable bleeding margins were achieved. Infection was controlled using vacuum sealing drainage (VSD) with continuous negative-pressure drainage and anti-infective therapy. The tracheostomy tube was subsequently inserted, replaced, and eventually removed without incident, and the patient recovered fully before discharge. This rare complication highlights impaired tracheal blood supply as a key etiology for necrosis. Timely diagnosis and staged surgical intervention are critical for managing post-thyroidectomy tracheal injuries.
C1 [Gao, Qiang; Gu, Pengfei; Liu, Song; Han, Yong] Binzhou Med Univ Hosp, Dept Thyroid Surg, Binzhou, Shandong, Peoples R China.
   [Gao, Qiang] Soochow Univ, Affiliated Hosp 2, Suzhou, Jiangsu, Peoples R China.
   [Wei, Yukun; Fan, Xiaorui; Xu, Wenjian] Binzhou Med Univ, Clin Med Coll 1, Binzhou, Shandong, Peoples R China.
C3 Shandong Medical & Pharmaceutical University; Soochow University -
   China; Shandong Medical & Pharmaceutical University
RP Han, Y (通讯作者)，Binzhou Med Univ Hosp, Dept Thyroid Surg, Binzhou, Shandong, Peoples R China.
EM hanyong2021@126.com
RI Gu, Pengfei/HNQ-0051-2023
CR Al-Qurayshi Z, 2020, GLAND SURG, V9, P1924, DOI 10.21037/gs-20-369
   Carter YM, 2012, ENDOCR PRACT, V18, P720, DOI [10.4158/EP12014.OR, 10.4158/EP11344.CR]
   Grewal HS, 2019, CHEST, V155, P595, DOI 10.1016/j.chest.2018.07.018
   Saleh ME, 2020, ASIAN CARD THORAC AN, V28, P22, DOI 10.1177/0218492319893822
   Salem FA, 2018, WORLD J SURG, V42, P2454, DOI 10.1007/s00268-018-4492-2
   Sony S, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.33910
   Spencer D, 2019, J SURG RES, V242, P200, DOI 10.1016/j.jss.2019.04.042
   Sreedharan Ranjith, 2018, J. vasc. bras., V17, P290, DOI [10.1590/1677-5449.004218, 10.1590/1677-5449.004218]
   Stevens MN, 2022, LARYNGOSCOPE, V132, P17, DOI 10.1002/lary.29534
   Xu XH, 2016, INT WOUND J, V13, P268, DOI 10.1111/iwj.12291
NR 10
TC 0
Z9 0
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD NOV 18
PY 2025
VL 25
IS 1
AR 556
DI 10.1186/s12893-025-03287-9
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9YM3X
UT WOS:001618045800001
PM 41254651
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zayan, NE
   West, JM
   Schulz, SA
   Jordan, SW
   Valerio, IL
AF Zayan, Nichole E.
   West, Julie M.
   Schulz, Steven A.
   Jordan, Sumanas W.
   Valerio, Ian L.
TI Incisional Negative Pressure Wound Therapy: An Effective Tool for Major
   Limb Amputation and Amputation Revision Site Closure
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; iNPWT; amputation; surgical site infection
ID SURGICAL INCISIONS; MANAGEMENT; FRACTURES; MORTALITY
AB Objective: To evaluate our institutional experience of incisional negative pressure wound therapy (iNPWT) applied immediately after major limb amputation closure or amputation revision closure. Approach: A retrospective review was performed on 25 patients who underwent major limb amputation or amputation revision and had iNPWT placed intraoperatively upon incision closure. Results: Twenty-one patients underwent lower extremity amputation and four underwent upper extremity amputation. Seventeen were primary amputations and eight were amputation revisions. No patients developed dehiscence, seroma, or hematoma. One patient developed a surgical site infection (4%) that was treated with oral antibiotics. The average time to eligibility for prosthetic fitting for lower extremity amputations was 6.3 weeks. Innovation: Amputee patients have increased wound healing demands that can impact prosthetic wear and ambulation status. Stump incisions are located at the distal end of their extremities and often are in areas that have had prior surgical procedures performed. Thus, blood supply to the incision site may not be optimal. iNPWT is an effective incision management technique to promote healing and decrease postoperative complications in this patient population, which can lead to increased mortality. Conclusion: iNPWT is an effective technique of minimizing wound complications in the amputee and should be considered in this high-risk patient population.
C1 [Zayan, Nichole E.; West, Julie M.; Schulz, Steven A.; Jordan, Sumanas W.; Valerio, Ian L.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
   [Jordan, Sumanas W.] Northwestern Univ, Div Plast Surg, Chicago, IL 60611 USA.
C3 University System of Ohio; Ohio State University; Northwestern
   University
RP Valerio, IL (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
EM ian.valerio@osumc.edu
RI Valerio, Ian/F-9161-2017
CR Advanced Amputee Solutions, 2012, AMP STAT
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NR 28
TC 18
Z9 19
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG 1
PY 2019
VL 8
IS 8
BP 368
EP 373
DI 10.1089/wound.2018.0935
EA MAR 2019
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IM5UY
UT WOS:000462593600001
PM 31346491
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Menn, ZK
   Lee, E
   Klebuc, MJ
AF Menn, Zachary K.
   Lee, Edward
   Klebuc, Michael J.
TI Acellular Dermal Matrix and Negative Pressure Wound Therapy: A
   Tissue-Engineered Alternative to Free Tissue Transfer in the Compromised
   Host
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE acellular; dermal; matrix; lower; extremity
ID MICROSURGICAL RECONSTRUCTION; INTEGRA; COMPLICATIONS; SURGERY
AB Free tissue transfer has revolutionized lower extremity reconstruction; however, its use in elderly patients with multiple medical problems can be associated with elevated rates of perioperative morbidity and mortality. This study evaluates the use of acellular dermal matrix (ADM) in conjunction with negative pressure wound therapy (NPWT) and delayed skin graft application as an alternative to free tissue transfer in this compromised population. Bilayer, ADM (Integra, Plainsboro, NJ) was used in conjunction with NPWT (Wound V. A. C, Kinetic Concepts Inc., San Antonio, TX) to achieve vascularized coverage of complex lower extremity wounds with denuded tendon and bone in elderly, medically compromised patients. Following incorporation, the matrix was covered with split-thickness skin graft. Four patients (age range, 50 to 76 years) with multiple medical comorbidities were treated with the above protocol. The average time to complete vascularization of the matrix was 29 days. Definitive closure with split-thickness skin graft was achieved in three patients and one wound healed by secondary intention. No medical or surgical complications were encountered and stable soft tissue coverage was achieved in all patients. This early experience suggests that dermal substitute and NPWT with delayed skin graft application can provide a reasonable tissue-engineered alternative to free tissue transfer in the medically compromised individual.
C1 [Menn, Zachary K.; Lee, Edward; Klebuc, Michael J.] Methodist Hosp, Inst Reconstruct Surg, Houston, TX 77030 USA.
C3 Houston Methodist
RP Klebuc, MJ (通讯作者)，6560 Fannin,Suite 2200, Houston, TX 77030 USA.
EM mklebuc@tmhs.org
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NR 14
TC 28
Z9 31
U1 1
U2 8
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD FEB
PY 2012
VL 28
IS 2
BP 139
EP 143
DI 10.1055/s-0031-1289167
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 912DX
UT WOS:000301776000009
PM 21959551
DA 2026-07-24
ER

PT J
AU Jha, NK
   Shafique, M
   Thomas, R
   Cruz, SP
   Tariq, G
   Kiraly, L
AF Jha, Neerod Kumar
   Shafique, Muhammad
   Thomas, Raisy
   Cruz, Salvacion Pangilinan
   Tariq, Gulnaz
   Kiraly, Laszlo
TI Sternal Wound Management in Pediatric Cardiac Surgical Patients: A Novel
   Strategic Interprofessional Approach
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE cardiac; infection; interprofessional; management; pediatric; sternum;
   surgery; wound care
ID INFECTIONS
AB OBJECTIVEInformation on sternal wound management in children after cardiac surgery is limited. The authors formulated a pediatric sternal wound care schematic incorporating concepts of interprofessional wound care and the wound bed preparation paradigm including negative-pressure wound therapy and surgical techniques to expedite and streamline wound care in children.METHODSAuthors assessed knowledge about sternal wound care among nurses, surgeons, intensivists, and physicians in a pediatric cardiac surgical unit regarding the latest concepts such as wound bed preparation, NERDS and STONEES criteria for wound infection, and early use of negative-pressure wound therapy or surgery. Management pathways for superficial and deep sternal wounds and a wound progress chart were prepared and introduced in practice after education and training.RESULTSThe cardiac surgical unit team members demonstrated a lack of knowledge about the current concepts of wound care, although this improved after education. The newly proposed management pathway/algorithm for superficial and deep sternal wounds and a wound progress assessment chart were introduced into practice. Results in 16 observed patients were encouraging, leading to complete healing and no mortality.CONCLUSIONSManaging pediatric sternal wounds after cardiac surgery can be streamlined by incorporating evidence-based current wound care concepts. In addition, the early introduction of advanced care techniques with appropriate surgical closure further improves outcomes. A management pathway for pediatric sternal wounds is beneficial.
C1 [Jha, Neerod Kumar; Thomas, Raisy; Kiraly, Laszlo] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
   [Shafique, Muhammad] Sheikh Khalifa Med City, Internal Med, Abu Dhabi, U Arab Emirates.
   [Cruz, Salvacion Pangilinan] Sheikh Khalifa Med City, Wound Care, Abu Dhabi, U Arab Emirates.
   [Tariq, Gulnaz] Wound Care Dept, Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
C3 Sheikh Khalifa Medical City; Sheikh Khalifa Medical City; Sheikh Khalifa
   Medical City; Sheikh Khalifa Medical City
RP Jha, NK (通讯作者)，Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates.
RI Kiraly, Laszlo/AHB-1719-2022
CR Anger J, 2015, REV BRAS CIR CARDIOV, V30, P114, DOI 10.5935/1678-9741.20140033
   Choukairi F., 2011, Wounds, V7, P99
   GILOD S, 2020, PEDIATR CRIT CARE ME, V21, P150
   Lindholm C, 2016, INT WOUND J, V13, P5, DOI 10.1111/iwj.12623
   National Healthcare Safety Network, EVENT
   Rupprecht Leopold, 2013, Open J Cardiovasc Surg, V6, P9, DOI 10.4137/OJCS.S11199
   Shi YD, 2014, ASIAN J SURG, V37, P24, DOI 10.1016/j.asjsur.2013.07.006
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   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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   Woodward CS, 2011, ANN THORAC SURG, V91, P799, DOI 10.1016/j.athoracsur.2010.10.030
NR 11
TC 5
Z9 6
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2023
VL 36
IS 5
BP 259
EP 266
DI 10.1097/01.ASW.0000924128.52669.ea
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA E9PY6
UT WOS:000978787400008
PM 37079789
DA 2026-07-24
ER

PT J
AU Howell, C
   Simman, R
AF Howell, Caroline
   Simman, Richard
TI Accidental intra-arterial injection of enoxaparin sodium leading to
   abdominal wall expanding subcutaneous hematoma and abdominal wound: case
   report-vascular
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Lovenox; subcutaneous hematoma; anticoagulant; negative pressure wound
   therapy; bleeding; intra-arterial injection
AB Introduction Enoxaparin sodium (Lovenox (R)) is a commonly used anticoagulant medication that is self-administered via subcutaneous injection to prevent the formation of pathologic blood clots. It is used as a bridge to long-term anticoagulation with warfarin in patients at high risk for thromboembolic events. It is generally well-tolerated and has a favorable safety profile. The most common injection site reactions caused by enoxaparin sodium are urticaria, ecchymosis, and skin and fat necrosis.Case Report A 56 year-old female with extensive thromboembolic history was completing an enoxaparin sodium bridge to warfarin when she accidentally self-injected enoxaparin sodium into the left superficial epigastric artery, resulting in the formation of a large expanding hematoma and the development of hemorrhagic shock. Controlling the bleeding required reversal of anticoagulation, transfusion, and coil embolization of the affected arteries. Surgical evacuation of the hematoma was performed, and the resultant wound was managed postoperatively with negative pressure wound therapy (NPWT) for one month. After discontinuation of NPWT, the wound was allowed to heal by secondary intention using dressing changes.Conclusions The findings of this case report suggest that NPWT followed by conventional dressings can be used to close and heal the wound created by surgical hematoma evacuation.
C1 [Howell, Caroline; Simman, Richard] Univ Toledo, Coll Med & Life Sci, Toledo, OH 43614 USA.
   [Simman, Richard] Univ Toledo, Dept Surg, Med Ctr, Div Plast & Reconstruct Surg, Toledo, OH 43614 USA.
   [Simman, Richard] Jobst Vasc Inst, Wound Care Program, ProMed Hlth Network, Toledo, OH 43606 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo
RP Simman, R (通讯作者)，Univ Toledo, Coll Med & Life Sci, Toledo, OH 43614 USA.; Simman, R (通讯作者)，Univ Toledo, Dept Surg, Med Ctr, Div Plast & Reconstruct Surg, Toledo, OH 43614 USA.; Simman, R (通讯作者)，Jobst Vasc Inst, Wound Care Program, ProMed Hlth Network, Toledo, OH 43606 USA.
EM Richard.SimmanMD@ProMedica.org
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NR 17
TC 2
Z9 3
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 22
PY 2025
VL 12
AR 1477926
DI 10.3389/fsurg.2025.1477926
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA U6T3H
UT WOS:001413088800001
PM 39911563
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhou, JQ
   Yu, JJ
   Hu, TS
   Li, JY
   Ding, CC
   Chen, LH
   Wu, H
   Zhang, M
AF Zhou, Jiaqi
   Yu, Jingjing
   Hu, Tianshuo
   Li, Jingyi
   Ding, Cuicui
   Chen, Lihui
   Wu, Hui
   Zhang, Min
TI Functionalized collagen-based sponge dressing integrating negative
   pressure wound therapy and photothermal antibacterial treatment for
   advanced wound management
SO BIOMATERIALS SCIENCE
LA English
DT Article
ID POLYVINYL-ALCOHOL FOAM; HYDROGELS; MEMBRANE; UV
AB Negative pressure wound therapy (NPWT) has proven effective in promoting wound healing. However, developing an NPWT sponge dressing that integrates good biocompatibility, mechanical stability under physiological conditions, and robust antibacterial properties remains challenging. In this study, a multifunctional graphene oxide/polyvinyl alcohol/collagen (GO/PVA/COL) composite sponge was prepared through a low-temperature foaming process. The introduction of GO significantly improved the mechanical properties of the composite sponge (maximum compressive stress = 20.2 kPa). Cyclic and long-term compression tests confirmed its excellent structural recovery in the wet state (permanent deformation rate 1.33% upon 0.05% GO). In aquatic environments, the composite sponge maintained stable performance under negative pressure suction up to 24 kPa, demonstrating high drainage efficiency. Moreover, GO endowed the composite sponge with a unique photothermal effect, enabling it to achieve inhibition rates exceeding 96% against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) under NIR irradiation. With the help of the photothermal effect, the composite sponge can effectively promote the repair of ulcerative wounds caused by infection. Additionally, the composite sponge displayed favorable in vitro biodegradability and cell compatibility. These findings highlight the potential of the GO/PVA/COL composite sponge as a novel NPWT dressing and provide a promising strategy for developing high-performance multifunctional wound therapy materials.
C1 [Zhou, Jiaqi; Hu, Tianshuo; Chen, Lihui; Wu, Hui; Zhang, Min] Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.
   [Yu, Jingjing; Ding, Cuicui] Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.
   [Li, Jingyi] Fujian Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Fuzhou 350122, Peoples R China.
   [Chen, Lihui; Zhang, Min] Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
C3 Fujian Agriculture & Forestry University; Fujian University of
   Technology; Fujian Medical University
RP Zhang, M (通讯作者)，Fujian Agr & Forestry Univ, Coll Mat Engn, Fuzhou 350002, Peoples R China.; Ding, CC (通讯作者)，Fujian Univ Technol, Sch Urban & Environm Engn, Fuzhou 350118, Peoples R China.; Zhang, M (通讯作者)，Natl Forestry & Grassland Adm, Key Lab Plant Fiber Funct Mat, Fuzhou 350108, Peoples R China.
EM dingcuicui.1124@163.com; mzhang@fafu.edu.cn
RI Chen, lihui/IXD-5425-2023; Ding, Cuicui/QIR-5181-2026
OI Chen, Li Hui/0009-0002-9978-9509
FU National Natural Science Foundation of China [22178056, 22078060]
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant No. 22178056 & 22078060), Outstanding Youth
   Natural Science Foundation of Fujian Province (Grant No. 2024J09047),
   Fuzhou Science and Technology Major Project (2023-ZD-008).
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   Yang LL, 2022, CHEM ENG J, V427, DOI 10.1016/j.cej.2021.131506
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   Zhou H, 2025, COLLOID SURFACE B, V256, DOI 10.1016/j.colsurfb.2025.114973
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2047-4830
EI 2047-4849
J9 BIOMATER SCI-UK
JI Biomater. Sci.
PD JUN 2
PY 2026
VL 14
IS 11
BP 2943
EP 2955
DI 10.1039/d6bm00297h
EA APR 2026
PG 13
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA IV4GO
UT WOS:001752533200001
PM 42052720
DA 2026-07-24
ER

PT J
AU Luo, RZ
   Liang, Y
   Yang, JR
   Feng, HQ
   Chen, Y
   Jiang, XP
   Zhang, Z
   Liu, J
   Bai, Y
   Xue, JT
   Chao, SY
   Xi, Y
   Liu, XQ
   Wang, EG
   Luo, D
   Li, Z
   Zhang, JP
AF Luo, Ruizeng
   Liang, Yi
   Yang, Jinrui
   Feng, Hongqing
   Chen, Ying
   Jiang, Xupin
   Zhang, Ze
   Liu, Jie
   Bai, Yuan
   Xue, Jiangtao
   Chao, Shengyu
   Xi, Yi
   Liu, Xiaoqiang
   Wang, Engui
   Luo, Dan
   Li, Zhou
   Zhang, Jiaping
TI Reshaping the Endogenous Electric Field to Boost Wound Repair via
   Electrogenerative Dressing
SO ADVANCED MATERIALS
LA English
DT Article
DE electric field therapy; epithelial regeneration; negative-pressure wound
   therapy; self-powered electrical simulation dressings; triboelectric
   nanogenerators
ID NEGATIVE-PRESSURE; COLLAGEN; LIFE
AB The endogenous electric field (EF) generated by transepithelial potential difference plays a decisive role in wound reepithelialization. For patients with large or chronic wounds, negative-pressure wound therapy (NPWT) is the most effective clinical method in inflammation control by continuously removing the necrotic tissues or infected substances, thus creating a proproliferative microenvironment beneficial for wound reepithelialization. However, continuous negative-pressure drainage causes electrolyte loss and weakens the endogenous EF, which in turn hinders wound reepithelialization. Here, an electrogenerative dressing (EGD) is developed by integrating triboelectric nanogenerators with NPWT. By converting the negative-pressure-induced mechanical deformation into electricity, EGD produces a stable and high-safety EF that can trigger a robust epithelial electrotactic response and drive the macrophages toward a reparative M2 phenotype in vitro. Translational medicine studies confirm that EGD completely reshapes the wound EF weakened by NPWT, and promotes wound closure by facilitating an earlier transition of inflammation/proliferation and guiding epithelial migration and proliferation to accelerate reepithelialization. Long-term EGD therapy remarkably advances tissue remodeling with mature epithelium, orderly extracellular matrix, and less scar formation. Compared with the golden standard of NPWT, EGD orchestrates all the essential wound stages in a noninvasive manner, presenting an excellent prospect in clinical wound therapy.
C1 [Luo, Ruizeng; Liang, Yi; Yang, Jinrui; Chen, Ying; Jiang, Xupin; Zhang, Ze; Liu, Jie; Liu, Xiaoqiang; Zhang, Jiaping] Third Mil Med Univ, Army Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury,Dept, Chongqing 400038, Peoples R China.
   [Luo, Ruizeng; Feng, Hongqing; Bai, Yuan; Xue, Jiangtao; Chao, Shengyu; Wang, Engui; Luo, Dan; Li, Zhou] Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China.
   [Luo, Ruizeng; Feng, Hongqing; Chao, Shengyu; Luo, Dan; Li, Zhou] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China.
   [Liang, Yi] Army 73rd Grp Mil Hosp, Dept Burn & Plast Surg, Xiamen 361000, Peoples R China.
   [Bai, Yuan; Luo, Dan; Li, Zhou] Guangxi Univ, Ctr Nanoenergy Res, Sch Phys Sci & Technol, Nanning 530004, Peoples R China.
   [Xue, Jiangtao] Beijing Inst Technol, Inst Engn Med, Beijing 100081, Peoples R China.
   [Xi, Yi] Chongqing Univ, Dept Appl Phys, Chongqing Key Lab Soft Condensed Matter Phys & Sma, State Key Lab Power Transmiss Equipment & Syst Sec, Chongqing 400044, Peoples R China.
   [Li, Zhou] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China.
C3 Army Medical University; Chinese Academy of Sciences; Beijing Institute
   of Nanoenergy & Nanosystems, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Guangxi University;
   Beijing Institute of Technology; Chongqing University; Chinese Academy
   of Sciences
RP Zhang, JP (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury,Dept, Chongqing 400038, Peoples R China.; Luo, D; Li, Z (通讯作者)，Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing 101400, Peoples R China.; Luo, D; Li, Z (通讯作者)，Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China.; Luo, D; Li, Z (通讯作者)，Guangxi Univ, Ctr Nanoenergy Res, Sch Phys Sci & Technol, Nanning 530004, Peoples R China.; Li, Z (通讯作者)，Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China.
EM luodan@binn.cas.cn; zli@binn.cas.cn; japzhang@aliyun.com
RI Liang, Yi/GLS-2479-2022; Yang, Jinrui/HGE-7359-2022; Xue,
   Jiangtao/OSI-0256-2025; bai, yuan/HDM-6641-2022; Li, Zhou/E-7734-2018;
   Feng, Hongqing/I-5222-2019
OI Xue, Jiangtao/0009-0002-3459-3513; Wang, Engui/0009-0005-6983-3929;
   Feng, Hongqing/0000-0003-2767-3080; 杨, 杨谨瑞/0000-0002-9120-6092; ,
   Jiaping/0000-0003-4034-883X
FU Strategic Priority Research Program of Chinese Academy of Sciences
   [XDA16021101]; National Natural Science Foundations of China [T2125003,
   81873936, 61875015, 51902344, 81971770]; Clinical Technology Innovation
   and Cultivation Project of Army Medical University [CX2019JS102];
   Beijing Natural Science Foundation [JQ20038, L212010]; National Key
   Research and Development Program of China [2021YFB3201200,
   2022YFB3200192]; Chongqing Natural Science Foundation
   [cstc2019jscxmsxmX0101]; outstanding project of the Youth training
   Program of Military Medical Science and Technology [21QNPY026]
FX R.L., Y.L., and J.Y. contributed equally to this work. The authors are
   grateful to all the laboratory members for their cooperation in this
   study. The authors thank Prof. Jianda Dong of the Ningxia Medical
   University for his help in the analysis of H&E staining. The authors are
   grateful for the support received from the Strategic Priority Research
   Program of Chinese Academy of Sciences (Grant No. XDA16021101), the
   National Natural Science Foundations of China (Grant Nos. T2125003,
   81873936, 61875015, 51902344, and 81971770), the Clinical Technology
   Innovation and Cultivation Project of Army Medical University (Grant No.
   CX2019JS102), the Beijing Natural Science Foundation (Grant Nos. JQ20038
   and L212010), the National Key Research and Development Program of China
   (Grant Nos. 2021YFB3201200, 2022YFB3200192), the Chongqing Natural
   Science Foundation (Grant No. cstc2019jscxmsxmX0101), and the
   outstanding project of the Youth training Program of Military Medical
   Science and Technology (Grant No. 21QNPY026). The authors thank Henan
   Huibo Medical Co., Ltd. for their technical support.
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NR 46
TC 186
Z9 191
U1 31
U2 399
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD APR
PY 2023
VL 35
IS 16
DI 10.1002/adma.202208395
EA MAR 2023
PG 15
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA E4TV8
UT WOS:000946164200001
PM 36681867
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Kim, PJ
   Attinger, CE
   Constantine, T
   Crist, BD
   Faust, E
   Hirche, CR
   Lavery, LA
   Messina, VJ
   Ohura, N
   Punch, LJ
   Wirth, GA
   Younis, I
   Teot, L
AF Kim, Paul J.
   Attinger, Christopher E.
   Constantine, Thomas
   Crist, Brett D.
   Faust, Elizabeth
   Hirche, Christoph R.
   Lavery, Lawrence A.
   Messina, Valerie J.
   Ohura, Norihiko
   Punch, Laurie J.
   Wirth, Garrett A.
   Younis, Ibby
   Teot, Luc
TI Negative pressure wound therapy with instillation: International
   consensus guidelines update
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWTi; topical wound solution; wound bioburden; wound cleansing; V; A;
   C; Veraflo therapy
AB The use of negative pressure wound therapy with instillation and dwell time (NPWTi-d) has gained wider adoption and interest due in part to the increasing complexity of wounds and patient conditions. Best practices for the use of NPWTi-d have shifted in recent years based on a growing body of evidence and expanded worldwide experience with the technology. To better guide the use of NPWTi-d with all dressing and setting configurations, as well as solutions, there is a need to publish updated international consensus guidelines, which were last produced over 6 years ago. An international, multidisciplinary expert panel of clinicians was convened on 22 to 23 February 2019, to assist in developing current recommendations for best practices of the use of NPWTi-d. Principal aims of the meeting were to update recommendations based on panel members' experience and published results regarding topics such as appropriate application settings, topical wound solution selection, and wound and patient characteristics for the use of NPWTi-d with various dressing types. The final consensus recommendations were derived based on greater than 80% agreement among the panellists. The guidelines in this publication represent further refinement of the recommended parameters originally established for the use of NPWTi-d. The authors thank Karen Beach and Ricardo Martinez for their assistance with manuscript preparation.
C1 [Kim, Paul J.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   [Attinger, Christopher E.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Constantine, Thomas] Toronto Cosmet Surg Inst, Dept Surg, Toronto, ON, Canada.
   [Crist, Brett D.] Univ Missouri Hlth Care, Dept Orthoped Surg, Columbia, MO USA.
   [Faust, Elizabeth] Tower Hlth Syst, Wound, Ost, W Reading, PA USA.
   [Hirche, Christoph R.] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Klin Plast & Handchirurg, Ludwigshafen, Germany.
   [Messina, Valerie J.; Wirth, Garrett A.] MemorialCare Long Beach Med Ctr, Wound Healing Ctr, Long Beach, CA USA.
   [Ohura, Norihiko] Kyorin Univ, Dept Plast & Reconstruct Surg, Sch Med, Tokyo, Japan.
   [Punch, Laurie J.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
   [Younis, Ibby] Royal Free Hosp, Dept Plast Surg, Univ Coll Hosp, London, England.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast Surg, Montpellier, France.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Georgetown University; University of Missouri System; University
   of Missouri Columbia; Ruprecht Karls University Heidelberg; Kyorin
   University; Washington University (WUSTL); University of London;
   University College London; Royal Free London NHS Foundation Trust; UCL
   Medical School; Universite de Montpellier; CHU de Montpellier
RP Kim, PJ (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Orthoped Surg, Dept Plast Surg, Dallas, TX 75390 USA.
EM paul.kim@utsouthwestern.edu
RI ; Crist, Brett/AAC-7535-2019
OI Lavery, Lawrence/0000-0002-7920-9952; , Paul/0000-0002-6186-6890; 
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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NR 30
TC 150
Z9 183
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2020
VL 17
IS 1
BP 174
EP 186
DI 10.1111/iwj.13254
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KC9VQ
UT WOS:000507520400022
PM 31667978
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Albassam, KM
   Kachwala, AI
   Alharbi, OM
AF Albassam, Khaled M.
   Kachwala, Aliasgar I.
   Alharbi, Obaid M.
TI Successful treatment of a rare retroperitoneal necrotizing soft tissue
   infection due to cranial spread of necrotizing perianal infection in
   COVID positive patient: a case report
SO KUWAIT MEDICAL JOURNAL
LA English
DT Article
DE necrotizing soft tissue infections; negative pressure wound therapy;
   retroperitoneal
ID FASCIITIS; DIAGNOSIS; MANAGEMENT; MORTALITY
AB Retroperitoneal necrotizing soft tissue infections (NSTI) are rare and a lethal disease. Delay in diagnosis and initiating treatment can lead to disastrous outcomes.
   This is a case of a 38-year-old young COVID positive male with retroperitoneal NSTI possibly due to cranial spread of ischiorectal necrotizing infection by E.coli, Salmonella enterica and bacteroides. On presentation, patient had high grade fever with left flank pain for three days and perianal discomfort for 10 days. Laboratory evaluation of unexplained sepsis revealed leucocytosis and acute kidney injury. Emergency computerized tomography scan of the abdomen showed gas in soft tissue, tracking along left psoas muscle. Initial emergency perianal debridement for source control relieved sepsis, but not abdominal pain. After initial improvement, patient deteriorated again. Further serial debridements by lumbotomy without contaminating peritoneal cavity lead to improvement. Wound closure was achieved by negative pressure wound therapy (NPWT) and secondary closure.
   Ischiorectal infection can spread to retroperitoneum, even in the absence of any definite fistulous connections. Once in preperitoneal space, it can spread rapidly to retroperitoneum and can cause profound sepsis. Early diagnosis, broad spectrum antibiotics and thorough debridement with adequate wound drainage can be lifesaving. NPWT can be very useful in patients with extensive wounds in COVID positive patients.
C1 [Albassam, Khaled M.; Kachwala, Aliasgar I.; Alharbi, Obaid M.] Farwaniya Hosp, Dept Gen Surg, Kuwait, Kuwait.
   [Alharbi, Obaid M.] KIMS, Kuwait, Kuwait.
RP Kachwala, AI (通讯作者)，Farwaniya Hosp, Dept Gen Surg, Kuwait, Kuwait.
EM dr.aliasgar@yahoo.co.in
RI Kachwala, Alimohammed/LFS-1550-2024
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   Yenigun A, 2020, J AM COLL SURGEONS, V231, P787, DOI 10.1016/j.jamcollsurg.2020.08.756
NR 23
TC 0
Z9 0
U1 0
U2 0
PU KUWAIT MEDICAL ASSOC
PI SAFAT
PA PO BOX 1202, SAFAT, 13013, KUWAIT
SN 1607-8047
EI 0023-5776
J9 KUWAIT MED J
JI Kuwait Med. J.
PD DEC
PY 2023
VL 55
IS 4
BP 354
EP 358
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM8J7
UT WOS:001194126900011
DA 2026-07-24
ER

PT J
AU Gregorík, M
   Szkorupa, M
   Chudácek, J
AF Gregorik, M.
   Szkorupa, M.
   Chudacek, J.
TI Negative Pressure Wound Therapy as a Treatment Option for Extensive
   Post-Trauma Subcutaneous Emphysema
SO ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
LA Czech
DT Article
DE negative pressure wound therapy; subcutaneous emphysema; rib fracture
ID MANAGEMENT
AB Subcutaneous emphysema can be a secondary complication of chest trauma or one of the complications of ruptured bullae in advanced chronic obstructive pulmonary disease. Massive subcutaneous emphysema impairs the respiratory mechanics and affects the venous returns of the head and neck. It can lead to respiratory insufficiency with the need for mechanical ventilation. The treatment should focus on the primary pathology. Nonetheless, in patients with subcutaneous emphysema as the only but serious symptom, the treatment can zero in solely on this complication. The standard procedure consists in the insertion of chest drain which does not necessarily have to lead to successful treatment results. The authors present a case study of a 77-year-old man with major comorbidities, with extensive subcutaneous emphysema after blunt chest wall trauma, in which respiratory insufficiency developed. The chest drain was ineffective. The solution was to apply subfascial negative pressure therapy infraclavicularly to the area of the pectoral muscle, which made the subcutaneous emphysema almost immediately subside and which substantially improved the clinical condition of the patient. Local negative pressure therapy can be used as the method of choice for treating massive subcutaneous emphysema in patients, in whom the standardised treatment by chest drain with active suction mechanism failed and the lung is expanded in the pleural cavity, and for whom surgery is far too risky.
C1 [Chudacek, J.] Univerz Palackeho Olomouci, Chirurg Klin Fak Nemocnice 1, Olomouc, Czech Republic.
   Univerz Palackeho Olomouci, Lekarske Fak, Olomouc, Czech Republic.
RP Chudácek, J (通讯作者)，I Chirurg Klin FN, IP Pavlova 185-6, Olomouc 77900, Czech Republic.; Chudácek, J (通讯作者)，LF UP Olomouci, IP Pavlova 185-6, Olomouc 77900, Czech Republic.
EM josef.chudacek@fnol.cz
RI /AAP-7370-2020; /ABH-5345-2020
CR Aghajanzadeh M, 2015, INDIAN J SURG, V77, pS673, DOI 10.1007/s12262-013-0975-4
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   Sciortino Christopher M, 2009, Eplasty, V9, pe1
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NR 8
TC 0
Z9 0
U1 0
U2 0
PU GALEN SRO
PI PRAGUE 5
PA NA BELIDLE 34, PRAGUE 5, 150 00, CZECH REPUBLIC
SN 0001-5415
J9 ACTA CHIR ORTHOP TR
JI Acta Chir. Orthop. Traumatol. Cechoslov.
PY 2021
VL 88
IS 6
BP 464
EP 467
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 1K7ZW
UT WOS:000798817200011
PM 34998452
DA 2026-07-24
ER

PT J
AU Zhao, YJ
   Wang, XK
   Song, JW
   Qu, ZJ
   Cao, GQ
   Wang, K
AF Zhao, Yujie
   Wang, Xiaokai
   Song, Jiwu
   Qu, Zhoujiang
   Cao, Guoqi
   Wang, Kun
TI Innovative Removal of Non-Marginally Exposed Hardware From the Frontal
   Region With Successful Wound Closure
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Dental high-speed handpiece; negative pressure wound therapy;
   non-marginal defects; scalp skin grafting; titanium mesh exposure
ID DECOMPRESSIVE CRANIECTOMY; DONOR SITE; CRANIOPLASTY; THERAPY; SCALP
AB Rationale:Titanium mesh is a common material for cranioplasty, but postoperative mesh exposure with infection poses a significant challenge-particularly for small, non-marginal defects where traditional instruments are ineffective.Patient concerns:A 41-year-old female developed an infected, non-marginal titanium mesh exposure in the frontal region 60 days after implantation, which followed traumatic brain injury surgery.Diagnoses:Open craniocerebral injury; open frontal bone fracture; focal cerebral contusion and laceration; status post-cranioplasty with titanium mesh; and exposure of frontal titanium mesh complicated by skin infection.Intervention:An innovative approach was used: (1) A dental high-speed handpiece (tungsten steel burr) was used to precisely resect the exposed mesh; (2) Negative pressure wound therapy was administered to promote granulation tissue formation; (3) A thin skin graft, harvested from the scalp, was transplanted in a second-stage procedure.Outcomes:The skin graft survived completely, with rapid healing at the donor site and no visible scarring. The wound closed fully, the infection resolved, and the aesthetic outcome was satisfactory.Lessons:For small, non-marginal titanium mesh exposure, the dental high-speed handpiece is an effective resection tool. When combined with scalp skin grafting, this protocol provides a simple, effective, and cosmetically favorable solution.
C1 [Wang, Xiaokai; Song, Jiwu; Cao, Guoqi; Wang, Kun] Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang, Shandong, Peoples R China.
   [Wang, Xiaokai; Cao, Guoqi] Shandong Second Med Univ, Clin Coll, Weifang, Shandong, Peoples R China.
   [Qu, Zhoujiang] Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Prosthodont, Weifang, Shandong, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University;
   Shandong Second Medical University
RP Cao, GQ; Wang, K (通讯作者)，Shandong Second Med Univ, Weifang Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang, Shandong, Peoples R China.; Cao, GQ (通讯作者)，Shandong Second Med Univ, Peoples Hosp, Affiliated Hosp 1, Dept Burns & Wound Repair, Weifang 261041, Shandong, Peoples R China.
EM 13965743207@163.com; 1317617818@qq.com; hckke@126.com;
   zhoujiangqu@163.com; clpguoqi@163.com; wangkun8192165@126.com
FU the Natural Science Foundation, Shandong Province [ZR2025QC1652] Funding
   Source: Medline
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2026
VL 37
IS 5
BP e431
EP e436
DI 10.1097/SCS.0000000000012435
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI4EK
UT WOS:001754791100006
PM 41603885
DA 2026-07-24
ER

PT J
AU Saeg, F
   Schoenbrunner, AR
   Janis, JE
AF Saeg, Fouad
   Schoenbrunner, Anna R.
   Janis, Jeffrey E.
TI Evidence-Based Wound Irrigation: Separating Fact from Fiction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID AESTHETIC BREAST AUGMENTATION; CAPSULAR CONTRACTURE; ANTIBIOTIC
   IRRIGATION; COMPLEX WOUNDS; THERAPY; EFFICACY; INSTILLATION; RISK;
   RECOMMENDATIONS; DEBRIDEMENT
AB The relationship between wound irrigation and healing has been recognized for centuries. However, there is little evidence and no official recommendations from any health care organization regarding best wound irrigation practices. This is the first review of wound irrigation that systematically summarizes the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and distills the evidence into a practical format. In this comprehensive review, the authors outline the irrigation fluids and delivery methods used in the identified studies, analyze reported treatment outcomes, summarize irrigation effectiveness, and propose evidence-based guidelines to improve wound healing outcomes and enhance the consistency of wound irrigation. Thirty-one high-quality studies with a combined total of 61,808 patients were included. Based on the current evidence provided by this review, the authors propose the following guidelines: (1) acute soft-tissue wounds should receive continuous gravity flow irrigation with polyhexanide; (2) complex wounds should receive continuous negative-pressure wound therapy with instillation with polyhexanide; (3) infected wounds should receive continuous negative-pressure wound therapy with instillation with silver nitrate, polyhexanide, acetic acid, or povidone-iodine; (4) breast implant wounds should receive gravity lavage with povidone-iodine or antibiotics; and (5) surgical-site infection rates can be reduced with intraoperative povidone-iodine irrigation.
C1 Tulane Univ, Sch Med, New Orleans, LA 70118 USA.
   [Janis, Jeffrey E.] Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
C3 Tulane University; University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast & Reconstruct Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
EM jeffrey.janis@osumc.edu
RI Janis, Jeffrey/W-6760-2019
OI Saeg, Fouad/0000-0003-3617-120X
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p82S, DOI 10.1097/PRS.0000000000002651
   Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
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   Campbell CA, 2018, ANN PLAS SURG, V80, pS398, DOI 10.1097/SAP.0000000000001345
   Chopra K, 2017, ANN PLAS SURG, V78, P629, DOI 10.1097/SAP.0000000000000942
   Davis KE, 2020, WOUND REPAIR REGEN, V28, P97, DOI 10.1111/wrr.12741
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   Fluieraru S, 2013, J WOUND CARE, V22, P293, DOI 10.12968/jowc.2013.22.6.293
   Fournel I, 2010, BJS-BRIT J SURG, V97, P1603, DOI 10.1002/bjs.7212
   Gabriel A., 2014, Eplasty, V14
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Giordano S, 2013, AESTHET SURG J, V33, P675, DOI 10.1177/1090820X13491490
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NR 44
TC 21
Z9 27
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2021
VL 148
IS 4
BP 601E
EP 614E
DI 10.1097/PRS.0000000000008331
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UU4JS
UT WOS:000698767600009
PM 34415884
DA 2026-07-24
ER

PT J
AU Nakanishi, R
   Ozawa, H
   Toyota, N
   Akutsu, R
   Fujita, S
AF Nakanishi, Ryo
   Ozawa, Heita
   Toyota, Naoyuki
   Akutsu, Ritsuto
   Fujita, Shin
TI Effectiveness of negative pressure wound therapy (NPWT) in preventing
   incisional surgical site infection after stoma closure: a single
   institutional retrospective study
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; NPWT; Stoma closure
ID SKIN CLOSURE; REVERSAL
AB PurposeRecent findings suggest that utilizing negative pressure wound therapy (NPWT) concurrently with stoma closure may decrease the risk of incisional surgical site infection (iSSI). However, the specific impact of NPWT on iSSI after stoma closure remains unclear. This study investigated the impact of NPWT on SSI after stoma closure.MethodsBetween January, 2010 and December, 2022, 185 patients underwent stoma closure at our hospital. Multivariate analysis was conducted to identify the risk factors for iSSI, using logistic regression analysis. Propensity score matching (PSM) was performed to balance the effect of potential co-factors of stoma closure with and without NPWT, on the incidence of superficial SSIs.ResultsMultivariate analysis identified that the absence of NPWT was an independent risk factor for iSSIs (Odds ratio [OR]: 11.1; 95% confidence interval [CI]: 1.88-64.9; P = 0.0078). Following cohort matching, the NPWT-absence and NPWT-presence groups comprised 54 patients each. The incisional SSI rate was significantly lower in the NPWT-presence group than in the NPWT-absence group (0.9%; n = 1 vs. 7.4%; n = 8, respectively; OR: 9.2; 95% CI 1.11-76.4; P = 0.04).ConclusionThe findings of this study demonstrated that stoma closure with NPWT reduced the SSI rates remarkably. Therefore, NPWT should be considered for stoma closure procedures.
C1 [Nakanishi, Ryo; Ozawa, Heita; Toyota, Naoyuki; Akutsu, Ritsuto; Fujita, Shin] Tochigi Canc Ctr, Dept Colorectal Surg, 4-9-13 Yohnan, Utsunomiya, Tochigi 3200834, Japan.
C3 Tochigi Prefectural Cancer Center
RP Nakanishi, R (通讯作者)，Tochigi Canc Ctr, Dept Colorectal Surg, 4-9-13 Yohnan, Utsunomiya, Tochigi 3200834, Japan.
EM one_piece_isoroku@hotmail.co.jp; heiozawa@tochigi-cc.jp;
   naoyuki.toyota@gmail.com; riakutsu@tochigi-cc.jp; sifujita@tochigi-cc.jp
OI Toyota, Naoyuki/0009-0004-0621-4883
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banerjee A, 1997, DIS COLON RECTUM, V40, P993, DOI 10.1007/BF02051210
   Cantero R, 2016, ADV SKIN WOUND CARE, V29, P114, DOI 10.1097/01.ASW.0000480458.60005.34
   Carrano FM, 2021, BJS OPEN, V5, DOI 10.1093/bjsopen/zrab116
   Kang SI, 2023, ANN SURG TREAT RES, V105, P126, DOI 10.4174/astr.2023.105.3.126
   Kim S, 2020, TRIALS, V21, DOI 10.1186/s13063-019-3925-z
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   Li LT, 2014, DIGEST SURG, V31, P73, DOI 10.1159/000354426
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   Yane Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05016-1
NR 13
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD MAY
PY 2025
VL 55
IS 5
BP 646
EP 651
DI 10.1007/s00595-024-02983-y
EA DEC 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1RJ9V
UT WOS:001385006400001
PM 39729103
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Timmermans, FW
   Mokken, SE
   Smit, JM
   Zwanenburg, PR
   van Hout, N
   Bouman, MB
   Middelkoop, E
   Mullender, MG
AF Timmermans, F. W.
   Mokken, S. E.
   Smit, J. M.
   Zwanenburg, P. R.
   van Hout, N.
   Bouman, M. B.
   Middelkoop, E.
   Mullender, M. G.
TI Within-patient randomized clinical trial comparing incisional
   negative-pressure wound therapy with suction drains in gender-affirming
   mastectomies
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID TO-MALE TRANSSEXUALS; WALL CONTOURING SURGERY; DEAD SPACE; MANAGEMENT;
   CLOSURE; TRANSGENDER; OUTCOMES
AB Background: Incisional negative-pressure wound therapy (iNPWT) is widely adopted by different disciplines for multiple indications. Questions about the most appropriate uses and value of iNPWT have been raised.
   Methods: An open-label within-patient RCT was conducted in transgender men undergoing gender-affirming mastectomies. The objective was to determine the effect of iNPWT as a substitute for standard dressing and suction drains on wound healing complications. One chest side was randomized to receive the iNPWT intervention, and the other to standard dressing with suction drain. The primary endpoints were wound healing complications (haematoma, seroma, infection, and dehiscence) after three months. Additional outcomes were pain according to a numerical rating scale and patient satisfaction one week after surgery.
   Results: Eighty-five patients were included, of whom 81 received both the iNPWT and standard treatment. Drain removal criteria were met within 24h in 95 per cent of the patients. No significant decrease in wound healing complications was registered on the iNPWT side, but the seroma rate was significantly increased. In contrast, patients experienced both significantly less pain and increased comfort on the iNPWT side. No medical device-related adverse events were registered.
   Conclusion: Substituting short-term suction drains with iNPWT in gender-affirming mastectomies increased the seroma rates and did not decrease the amount of wound healing complications.
C1 [Timmermans, F. W.; Mokken, S. E.; Smit, J. M.; Zwanenburg, P. R.; van Hout, N.; Bouman, M. B.; Middelkoop, E.; Mullender, M. G.] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci, Amsterdam UMC, Amsterdam, Netherlands.
   [Timmermans, F. W.; Mokken, S. E.; Smit, J. M.; van Hout, N.; Bouman, M. B.; Mullender, M. G.] Vrije Univ Amsterdam, Ctr Expertise Gender Dysphoria, Amsterdam UMC, Amsterdam, Netherlands.
   [Mokken, S. E.; Bouman, M. B.; Mullender, M. G.] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Publ Hlth, Amsterdam UMC, Amsterdam, Netherlands.
   [Smit, J. M.; Zwanenburg, P. R.; van Hout, N.; Bouman, M. B.; Mullender, M. G.] Amsterdam Med Ctr, Dept Plast Reconstruct & Hand Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Middelkoop, E.] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Amsterdam; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Timmermans, FW (通讯作者)，Amsterdam UMC Locat VUmc, Dept Plast Reconstruct & Hand Surg, De Boelelaan 1117, Amsterdam, Netherlands.
EM f.timmermans@amsterdamumc.nl
RI ; Mullender, Margriet/PWH-3332-2026; Middelkoop, Esther/M-3735-2014
OI Mokken, Sterre/0000-0002-8891-969X; Mullender,
   Margriet/0000-0001-6407-5405; Bouman, Mark-Bram/0000-0002-4245-783X;
   Middelkoop, Esther/0000-0001-8843-1080
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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NR 39
TC 5
Z9 5
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD AUG
PY 2021
VL 108
IS 8
BP 925
EP 933
DI 10.1093/bjs/znab204
EA JUL 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA US4BV
UT WOS:000697377700030
PM 34244715
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER

PT J
AU Cimmino, AA
   Marangi, GF
   D'Onofrio, G
   Gratteri, M
   Porso, D
   Romano, FD
   Mirra, C
   Persichetti, P
AF Cimmino, Andrea Aniello
   Marangi, Giovanni Francesco
   D'Onofrio, Gianluca
   Gratteri, Marco
   Porso, Daniela
   Romano, Fara Desiree
   Mirra, Carlo
   Persichetti, Paolo
TI Total Capsulectomy and NPWT for Management of a Mycobacterium abscessus
   Breast Implant Infection Unresponsive to Antimicrobial Therapy A Case
   Report and Literature Review
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE breast implant infection; mycobacterial infection; wound management;
   negative pressure wound therapy
ID AUGMENTATION MAMMAPLASTY; SURGERY
AB Background. Nontuberculous mycobacteria (NTM) periprosthetic infections after breast augmentation procedures are increasingly common worldwide and should raise suspicion after empirical antimicrobial therapy fails but clinical signs of infection persist. In this case experience, the authors suggest the use of negative pressure wound therapy (NPWT) for NTM-infected wounds to obtain a faster periprosthetic space closure, shorten healing time, and anticipate breast reimplantation. Case Report. This case report describes the successful application of NPWT to manage wound healing after breast implant removal in a 60-year-old female who underwent secondary breast augmentation 7 years before. The patient presented with an Mycobacterium abscessus infection of the left breast after lung segmentectomy that persisted post-implant removal and targeted antibiotic therapy. Based on clinical and laboratory findings, the authors opted for a debridement of the periprosthetic space associated to a radical capsulectomy. Application of NPWT for wound drainage and closure allowed a faster recovery, reduced interval from implant removal to reimplantation, and led to a pleasant cosmetic result. Conclusion. The use of NPWT for wound management after NTM peri-implant infection may help to encourage faster periprosthetic space drainage and closure, thus expediting the timing of a negative culture and breast reimplantation.
C1 [Cimmino, Andrea Aniello; Marangi, Giovanni Francesco; D'Onofrio, Gianluca; Gratteri, Marco; Porso, Daniela; Romano, Fara Desiree; Mirra, Carlo; Persichetti, Paolo] Univ Campus Biomed Roma, Dept Plast Reconstruct & Aesthet Surg, Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy
RP Cimmino, AA (通讯作者)，Campus Biomed Univ Rome, Unit Plast & Reconstruct Surg, Via Alvaro del Portillo 200, I-00128 Rome, Italy.
EM andrea.cimmino@unicampus.it
RI Gratteri, Marco/KGM-5481-2024; Marangi, Giovanni/AAW-4723-2020
CR Al-Halabi B, 2018, PLAST RECONSTR SURG, V142, p639E, DOI 10.1097/PRS.0000000000004892
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NR 23
TC 2
Z9 2
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2024
VL 36
IS 11
BP 392
EP 396
DI 10.25270/wnds/24033
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA P9O6Z
UT WOS:001381115100006
PM 39666907
DA 2026-07-24
ER

PT J
AU Brega, C
   Calvi, S
   Albertini, A
AF Brega, Carlotta
   Calvi, Simone
   Albertini, Alberto
TI Use of a negative pressure wound therapy system over closed incisions
   option in preventing post-sternotomy wound complications
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE negative pressure therapy; post&#8208; sternotomy infections; surgical
   wound infection
ID MEDIAN STERNOTOMY; INFECTIONS; DRESSINGS; RISK
AB Post-sternotomy surgical site infections may be serious complications responsible for increased morbidity, mortality and length of hospital stay. A variety of wound-healing strategies can be used over closed surgical incisions, including negative pressure wound therapy (NPWT). The aim of the study is to assess sternal wound complications after heart surgery using NPWT in patients at risk for surgical site complication. Considered risk factors affecting wound healing were type 2 diabetes, Body Mass Index (BMI) >30, chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF) and myocardial revascularization by double mammary artery harvesting. With these premises, 90 patients were selected: 30 patients received traditional gauze dressings, 30 advanced dressings (hydrocolloid and carboxymethyl cellulose) and 30 patients NPWT. Thirty-four patients (37.7%) had two risk factors, 41 patients (45.5%) were affected by three risk factors and 15 patients (16.6%) by four risk factors. The NPWT group had lower rates of diabetes and CRF and only one patient presented four risk factors. With regard to surgical times and types of surgical procedure, no significant differences were observed within the three groups. The patients who received NPWT over closed incision experimented a significantly lower rate of deep sternal complication over traditional gauze and hydrocolloid and carboxymethyl cellulose dressings.
C1 [Brega, Carlotta; Calvi, Simone; Albertini, Alberto] GVM Care & Res, Cardiovasc Dept, Maria Cecilia Hosp, Cotignola, Italy.
C3 Maria Cecilia Hospital
RP Brega, C (通讯作者)，GVM Care & Res, Maria Cecilia Hosp, Via Corriera 1, I-48010 Cotignola, RA, Italy.
EM carlottabrega@icloud.com
RI Brega, Carlotta/J-4656-2019; Albertini, Alberto/KQV-4794-2024
OI Brega, Carlotta/0000-0002-6935-9295; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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   Centers for Disease Control and Prevention, 2016, NAT HEALTHC SAF NETW
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NR 18
TC 9
Z9 10
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2021
VL 29
IS 5
BP 848
EP 852
DI 10.1111/wrr.12914
EA MAR 2021
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA UK1FO
UT WOS:000634288100001
PM 33780088
DA 2026-07-24
ER

PT J
AU Mastrocco, A
   Prittie, J
AF Mastrocco, Alicia
   Prittie, Jennifer
TI Early and aggressive surgical debridement and negative pressure wound
   therapy to treat necrotizing fasciitis in three dogs
SO VETERINARY SURGERY
LA English
DT Article
ID SOFT-TISSUE INFECTIONS; DETERMINANTS; MANAGEMENT; DIAGNOSIS; MORTALITY;
   NEED
AB Objective To report the management and outcomes of dogs with necrotizing fasciitis (NF) treated with early, aggressive surgical debridement and negative pressure wound therapy (NPWT).
   Study design Short case series.
   Animals Three dogs surgically treated for NF.
   Methods Clinical signs in the three dogs included an identified wound, severe pain, fever, and progressive erythema. A tentative diagnosis of NF was based on the presence of suppurative inflammation and intracellular bacteria seen in fine needle aspirates and clinical progression in each case. Each dog was treated with surgical debridement within 6 hours of clinical suspicion for NF. Necrosis affected multiple tissue layers was noted surgical exploration. Systemic supportive care and antibiotherapy were also provided for 3 to 4 weeks postoperatively.
   Results Three surgical debridements were required in two dogs, and four surgical debridements were required in one dog. All of the surgical sites were managed with NPWT until final primary closure was possible at 4, 5, and 6 days after initial surgery. Results of histopathology and culture of the surgical sites were consistent with NF as described in each case. All dogs survived to discharge and long-term follow up.
   Conclusion Management with early surgery, multiple debridements, and the use of NPWT led to resolution of NF in three dogs.
C1 [Mastrocco, Alicia; Prittie, Jennifer] Anim Med Ctr, Emergency & Crit Care, New York, NY USA.
RP Mastrocco, A (通讯作者)，510 E 62nd St, New York, NY 10065 USA.
EM alicia.mastrocco@amcny.org
OI Mastrocco, Alicia/0000-0002-0110-9927
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NR 19
TC 1
Z9 1
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD NOV
PY 2021
VL 50
IS 8
BP 1662
EP 1669
DI 10.1111/vsu.13576
EA MAR 2021
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA WN9JB
UT WOS:000629209800001
PM 33724500
DA 2026-07-24
ER

PT J
AU Chan, BCF
   Campbell, KE
AF Chan, Brian C-F
   Campbell, Karen E.
TI An economic evaluation examining the cost-effectiveness of continuous
   diffusion of oxygen therapy for individuals with diabetic foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost-benefit analysis; diabetic foot
ID PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN; TOPICAL OXYGEN; DOUBLE-BLIND;
   POPULATION; MORTALITY; ASSOCIATION; MULTICENTER; MANAGEMENT; AMPUTATION
AB Continuous delivery of oxygen therapy has been observed to improve healing for individuals with an advanced diabetic foot ulcer (DFU). However, this intervention requires the purchasing of an oxygen delivery device and moist dressings. It is unknown whether this upfront financial investment represents good value for money. Thus the aim of this project is to evaluate the cost-effectiveness of treating advanced DFU using continuous delivery of oxygen compared with negative pressure wound therapy from the perspective of the public health care payer in Ontario, Canada. A microsimulation model was constructed with inputs from peer-reviewed journal publications and publicly available reports. The 5-year costs and quality-adjusted life-years were compared between treatment and comparator. Sensitivity analyses were conducted to evaluate the robustness of results. The model predicted that continuous delivery of oxygen would cost $4800 less compared with negative pressure wound therapy and increased quality-adjusted life years by 0.025. Lower cost and improved outcomes were observed in most scenario analyses. The results of this economic evaluation suggest that CDO therapy may reduce health care economic burden with a modest increase in quality of life outcomes. Health care decision-makers should consider the inclusion of CDO for the treatment of DFU.
C1 [Chan, Brian C-F] Univ Hlth Network, KITE Toronto Rehabil Inst, 520 Sutherland Dr,Room 206, Toronto, ON M4G 3V9, Canada.
   [Chan, Brian C-F] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Campbell, Karen E.] Western Univ, Fac Hlth Sci, Sch Phys Therapy, London, ON, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   Rehabilitation Institute; University of Toronto; Western University
   (University of Western Ontario)
RP Chan, BCF (通讯作者)，Univ Hlth Network, KITE Toronto Rehabil Inst, 520 Sutherland Dr,Room 206, Toronto, ON M4G 3V9, Canada.
EM brian.chan@uhn.ca
RI Chan, Brian/AAF-3874-2021
OI Chan, Brian/0000-0001-5037-0446
FU EO2 Concepts Incorporated
FX EO2 Concepts Incorporated
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NR 54
TC 14
Z9 18
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1791
EP 1808
DI 10.1111/iwj.13468
EA JUL 2020
PG 18
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000552620400001
PM 33189100
OA Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Cho, J
   Hwang, H
   Song, SY
   Suh, HP
   Hong, JP
AF Cho, Jeongmok
   Hwang, Hyun
   Song, Shin Young
   Suh, Hyunsuk Peter
   Hong, Joon Pio
TI Evaluation of wound healing effects of micronized acellular dermal
   matrix in combination with negative pressure wound therapy: In vivo
   study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE collagen; gelatin; micronized acellular dermal matrix; porcine model;
   wound healing
ID DIABETIC FOOT ULCERS; EFFICACY; ENHANCE; PASTE
AB Acellular dermal matrix (ADM) grafts can provide coverage for full-thickness skin defects and substitute for dermal defects. We tested the effectiveness of micronized ADM (mADM) as a dressing material, combined with negative pressure wound therapy (NPWT), for managing superficial wounds. We compared the wound healing effect of mADM in combination with NPWT with those of gelatin and mADM applied with a foam dressing. These therapeutic materials were applied to 36 cm(2) excisional wounds in a porcine full-thickness skin defect model. Wound healing kinetics and new tissue formation were assessed 10 days after the initial treatment by measuring the wound area. Collagen deposition and neovascularization were histologically evaluated. Compared with the other two groups, mADM plus NPWT combination group had a significantly larger wound area at the baseline (P = .0040), but the smallest on the 7th day (P = .0093). In addition, collagen formation and neovascularization were more histologically promoted than in the other two groups. mADM showed better results than the gelatin group but less collagen and revascularization than the combination group, and there was no significant difference in wound area. Our results show that the combination of mADM and NPWT has a synergistic wound healing effect.
C1 [Cho, Jeongmok; Song, Shin Young; Suh, Hyunsuk Peter; Hong, Joon Pio] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Plast & Reconstruct Surg, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Hwang, Hyun] Emory Univ, Sch Med, Dept Pediat, Div Pediat Cardiol, Atlanta, GA USA.
   [Hwang, Hyun] Childrens Healthcare Atlanta, Atlanta, GA USA.
C3 University of Ulsan; Asan Medical Center; Emory University; Children's
   Healthcare of Atlanta (CHOA)
RP Suh, HP (通讯作者)，Univ Ulsan, Asan Med Ctr, Coll Med, Dept Plast & Reconstruct Surg, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM hyunsuk.suh@amc.seoul.kr
RI ; Hong, Joon/AEV-0712-2022
OI Cho, Jeong Mok/0000-0002-5957-467X; 
FU Daewoong Foundation
FX Daewoong Foundation
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NR 22
TC 9
Z9 10
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2023
VL 20
IS 4
BP 1053
EP 1060
DI 10.1111/iwj.13958
EA SEP 2022
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A7RQ8
UT WOS:000860969600001
PM 36165089
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cwalinski, J
   Hermann, J
   Banasiewicz, T
   Paszkowski, J
AF Cwalinski, Jaroslaw
   Hermann, Jacek
   Banasiewicz, Tomasz
   Paszkowski, Jacek
TI Atypical and Life-threatening Crohn's Disease Following Colectomy: A
   Case Report
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE case study; Crohn's Disease; postoperative complications; medical
   nutrition therapy; negative pressure wound therapy
ID POSTOPERATIVE COMPLICATIONS; MANAGEMENT; RELAPAROTOMY; THERAPY; FISTULA
AB Although Crohn's Disease (CD) usually occurs between the second and third decade of life, it also may develop in older adults.Treating elderly patients may be challenging due to other comorbidities, including diverticular disease or intestinal ischemia.PURPOSE: The purpose of this case study was to describe successful treatment of atypical and life-threatening CD due to enterocutaneous fistulas with short-bowel syndrome and multiorgan failure after partial colectomy. CASE REPORT: After an urgent colectomy for an inflammatory colon tumor, a 64-year-old woman with a history of CD and multiple comorbidities developed acute small bowel ischemia. Following an extended bowel resection, she developed a severe surgical site infection,entero- and gastrocutaneous fistulas, multi organ failure, and short bowel syndrome. Her care included intensive medical and nutritional treatment as well as negative pressure wound therapy (NPWT) using continuous negative pressure of -80 mm Hg.She not only survived, but she also achieved complete wound closure and restoration of digestive tract continuity and metabolic control. She was discharged with a central venous catheter on total parenteral nutrition. CONCLUSION: In this case study,a good outcome was observed using intensive medical treatment, nutritional therapy, and conservative surgical treatment that included NPWT for a patient with CD and major comorbidities who developed postoperative complications.
C1 [Cwalinski, Jaroslaw; Hermann, Jacek; Banasiewicz, Tomasz; Paszkowski, Jacek] Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przbyszewskiego 49, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Cwalinski, J (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol Surg & Gastroenterol Oncol, Przbyszewskiego 49, PL-60355 Poznan, Poland.
EM jaroslaw.cwalinski@gmail.com
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NR 25
TC 0
Z9 0
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD JUL
PY 2019
VL 65
IS 7
BP 36
EP 40
DI 10.25270/wmp.2019.7.3640
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA JF7JE
UT WOS:000491561700006
PM 31373562
DA 2026-07-24
ER

PT J
AU Andersson, S
   Monsen, C
   Acosta, S
AF Andersson, Sebastian
   Monsen, Christina
   Acosta, Stefan
TI Outcome and Complications Using Negative Pressure Wound Therapy in the
   Groin for Perivascular Surgical Site Infections after Vascular Surgery
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID GRAFT INFECTION; PREVENTION; CLOSURE; MICROBIOLOGY; MANAGEMENT
AB Background: The aim of this study was to investigate graft preservation, major bleeding, and reinfection rate using negative pressure wound therapy (NPWT) for perivascular surgical site infections (SSIs) in the groin after vascular surgery and factors associated with failure of treatment.
   Methods: Retrospective data were collected during 2004-2015. Failure of wound treatment was defined as a wound not healed within 4 months, visible graft material or native artery after 1 month, bleeding from the wound leading to discontinuation of treatment, or death or amputation due to the groin infection.
   Results: The median age of the 161 patients was 71 years; 63% were men. The rate of graft preservation rate was 81%; 64% for synthetic grafts. Major bleeding during NPWT occurred in 7.1% and local reinfection in 6.4%. Synthetic graft infection (odds ratio [OR] = 6.1, 95% confidence interval [CI] = 2.6-14.4) and bleeding/pseudoaneurysm as presenting symptom (OR = 2.9, 95% CI = 1.0-8.2) were independently associated with increased failure rate of treatment.
   Conclusions: NPWT is a good option for perivascular SSI in the groin after vascular surgery. Patients with a synthetic graft infection and/or presenting with pseudoaneurysm or bleeding may be considered for an adjunctive or alternative treatment option.
C1 [Andersson, Sebastian; Monsen, Christina; Acosta, Stefan] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Andersson, Sebastian; Monsen, Christina; Acosta, Stefan] Skane Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Ctr, Malmo, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Lund Univ, Dept Clin Sci, Vasc Surg, Ruth Lundskogsg 10, S-20502 Malmo, Sweden.
EM stefan.acosta@med.lu.se
RI Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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NR 21
TC 10
Z9 13
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2018
VL 48
BP 104
EP 110
DI 10.1016/j.avsg.2017.10.018
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA FZ4PR
UT WOS:000427574700010
PM 29217444
DA 2026-07-24
ER

PT J
AU Gonzalez, TD
   Ribaric, I
   Gomes, YM
   André, MM
   Zua, FQD
   Gonçalves, MAD
   Ivo, M
   Leonhardt, MD
   Silva, JD
   Kojima, KE
AF Gonzalez, Theodoro Da Cunha
   Ribaric, Ivan
   Gomes, Yuri Macari
   Andre, Mbilu Miguel
   Zua, Fernando Quissolo Dalaia
   Goncalves, Maria Adelaide De Miranda
   Ivo, Mauricio
   Leonhardt, Marcos De Camargo
   Silva, Jorge Dos Santos
   Kojima, Kodi Edson
TI RETROSPECTIVE ANALYSIS OF THE IMPACT OF NEGATIVE PRESSURE WOUND THERAPY
   ON COMPLICATIONS OF DELAYED COVERAGE OF IIIB EXPOSED TIBIAL FRACTURES
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Negative-Pressure Wound Therapy; Fractures, Ununited; Amputation
ID RISK-FACTORS; MANAGEMENT; INFECTION; NONUNION; OUTCOMES
AB Objective: To evaluate whether NPWT in delayed coverage of Gustilo-Anderson Type IIIB open tibial fractures reduces the complication rate, including deep infection, nonunion, and amputation. Methods: Retrospective case series including patients with Gustilo-Anderson Type IIIB open tibial shaft fractures treated between January 2014 and December 2017 with NPWT. The outcome measures were incidence of deep infection, nonunion, and amputation. Analysis of time to coverage (within 7 days vs. after 7 days) and type of soft tissue coverage. Results: 26 patients with open tibial shaft fractures, predominantly male (96.2%), mean age 33.4 +/- 13.9 years. Seven patients (26.9%) received coverage within 7 days; 19 patients (73.1%) received delayed coverage. The flap types were Myocutaneous (42.3%), microsurgical (34.6%), fasciocutaneous (23.1%). The overall infection rate was 50%, no significant difference between early (57.1%) and delayed (47.4%) coverage groups (p > 0.999). No amputations in the early coverage group; 2 (10.5%) in the delayed coverage group. Nonunion rates were 42.9% (early) and 36.8% (delayed). Overall complication rate: 85.7% (early) vs. 57.9% (delayed) (p = 0.357). Conclusion: NPWT may exert a protective effect in cases of delayed coverage by isolating the wound and promoting healing. Level of Evidence III; Retrospectivef study.
C1 [Gonzalez, Theodoro Da Cunha; Ribaric, Ivan; Gomes, Yuri Macari; Andre, Mbilu Miguel; Zua, Fernando Quissolo Dalaia; Goncalves, Maria Adelaide De Miranda; Ivo, Mauricio; Leonhardt, Marcos De Camargo; Silva, Jorge Dos Santos; Kojima, Kodi Edson] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Grp Trauma,Inst Ortoped & Traumatol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Kojima, KE (通讯作者)，333 Rua Dr Ovidio Pires Campos, BR-05402000 Sao Paulo, SP, Brazil.
EM kodi.kojima@hc.fm.usp.br
RI Santos Silva, Jorge dos Santos Silva/GMW-8109-2022; Kojima,
   Kodi/ACN-8737-2022
OI Ane, Mbilu Miguel/0009-0009-1260-0672; Macari Gomes,
   Yuri/0009-0002-1184-7867
CR Al-Hourani K, 2021, INJURY, V52, P378, DOI 10.1016/j.injury.2021.01.021
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PY 2025
VL 33
SI SI
AR e290249
DI 10.1590/1413-785220253303e290249
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AX4SU
UT WOS:001659081200005
PM 41393529
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU MacLeod, BG
   Klarich, CS
   Wessman, LL
   Gaddis, KJ
   Konstantinov, NK
   Wubben, A
   Melin, MM
AF MacLeod, Brett G.
   Klarich, Carissa S.
   Wessman, Laurel L.
   Gaddis, Kevin J.
   Konstantinov, Nikifor K.
   Wubben, Angie
   Melin, M. Mark
TI Fluorescent Imaging as a Component of Diagnosing Pyoderma Gangrenosum: A
   Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Editorial Material
DE adalimumab; fluorescent imaging; hypochlorous acid; negative-pressure
   wound therapy; pyoderma gangrenosum; vitamin D
ID MANAGEMENT; THERAPY
AB A 64-year-old White woman was admitted to the hospital with complaint of progressive right hip ulceration at the wound site following a total right hip arthroplasty. Initial history and physical examination gave a leading differential diagnosis of pyoderma gangrenosum. Until recently, the exclusion of infection for pyoderma gangrenosum has been largely clinical and supported by cultures/biopsies demonstrating the absence of infection. The MolecuLight i:X (MolecuLight, Toronto, Ontario, Canada) is a novel bedside fluorescent imaging device capable of determining the bacterial burden within a wound in real time. Fluorescent imaging excluded infection at the initial visit, and debridement was avoided. Subsequently, pathergy was avoided as well. The patient was started on topical clobetasol with hypochlorous acid-soaked dressings. She also received 80 mg daily of prednisone and high-dose vitamin D3 (10,000 IU). Recovery was complicated by a deep tunnel along the incisional line at 3 months postdiagnosis, which required slowing of the prednisone taper and the addition of colchicine. Repeat cultures grew Parvimonas, Pseudomonas, and Streptococcus species. Appropriate antibiotics were given. The patient was transitioned from prednisone to adalimumab and started on negativepressure wound therapy. Negative-pressure wound therapy was discontinued at 5 months, and the wound resolved at 6 months.
C1 [MacLeod, Brett G.; Klarich, Carissa S.] Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA.
   [Wessman, Laurel L.; Gaddis, Kevin J.; Konstantinov, Nikifor K.] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA.
   [Wubben, Angie; Melin, M. Mark] M Hlth Fairview Wound Healing Inst, Edina, MN USA.
C3 University of North Dakota Grand Forks; University of Minnesota System;
   University of Minnesota Twin Cities
RP MacLeod, BG (通讯作者)，Univ North Dakota, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA.
CR Al Ghazal P, 2014, J DTSCH DERMATOL GES, V12, P1129, DOI 10.1111/ddg.12401
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   Dunnill C, 2017, INT WOUND J, V14, P89, DOI 10.1111/iwj.12557
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   Sakarya S, 2014, WOUNDS, V26, P342
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   Viswanath V, 2020, DERMATOL THER, V33, DOI 10.1111/dth.13965
   Watters C, 2015, CHRONIC WOUND CARE M, V2, P53, DOI 10.2147/CWCMR.S60317
   Wilkes R, 2009, J MECH BEHAV BIOMED, V2, P272, DOI 10.1016/j.jmbbm.2008.10.006
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NR 28
TC 5
Z9 6
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2022
VL 35
IS 6
DI 10.1097/01.ASW.0000820248.26138.bc
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 2C7NK
UT WOS:000811050100001
PM 35426849
DA 2026-07-24
ER

PT J
AU Tsutsumi, K
   Yamanaka, N
   Tokioka, M
   Ishida, O
AF Tsutsumi, Koji
   Yamanaka, Nozomi
   Tokioka, Misato
   Ishida, Osamu
TI The Effect of Closed Incision Negative Original Pressure Wound Therapy
   for Prophylactic Article Use of Postoperative Deep Sternal Wound
   Infection in Patients Following Coronary Artery Bypass Grafting: A
   Single-Institutional Study
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE negative pressure wound therapy; sternal wound infection; prevention
AB Purpose: The aim of this study was to evaluate the effectiveness of closed-incision negative pressure wound therapy (ciNPWT) as a prophylactic measure to prevent deep sternal wound infection (DSWI) after surgery. Methods: A total of 209 patients undergoing isolated coronary artery bypass grafting via median sternotomy were enrolled. The patients were divided into 3 groups according to incisional care. In Group A (n = 63), the wound was covered with sterile gauze dressings alone. In Group B (n = 71), an indwelling subcutaneous drain was placed and the wound was covered with a hydrocolloid dressing. In Group C (n = 75), an indwelling subcutaneous drain was placed and the wound was covered with a ciNPWT device (PICO; Smith & Nephew). The incidence of DSWI occurring within 60 postoperative days was compared among the 3 groups. Results: There were no significant differences in preoperative, operative, or postoperative variables among the groups. Postoperative DSWI occurred in 11.1% (7/63) of patients in Group A and 5.6% (4/71) of patients in Group B, whereas no patients in Group C developed DSWI. Conclusions: Immediate application of NPWT was associated with a reduced rate of wound infection. This treatment may represent an effective preventive strategy.
C1 [Tsutsumi, Koji; Yamanaka, Nozomi; Tokioka, Misato; Ishida, Osamu] Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama, Japan.
C3 National Defense Medical College - Japan
RP Tsutsumi, K (通讯作者)，Natl Def Med Coll, Dept Cardiovasc Surg, 3-2 Namiki, Tokorozawa, Saitama, Japan.
EM con318@ndmc.ac.jp
RI Ishida, Osamu/GRJ-5887-2022
CR Chen DS, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14457
   de Tymowski C, 2025, SURGERY, V181, DOI 10.1016/j.surg.2025.109255
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Kanda Y, 2013, BONE MARROW TRANSPL, V48, P452, DOI 10.1038/bmt.2012.244
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   Nherera LM, 2018, J CARDIOTHORAC SURG, V13, DOI 10.1186/s13019-018-0786-6
   Oliveira FD, 2017, ARQ BRAS CARDIOL, V109, P207, DOI 10.5935/abc.20170119
   Rupprecht Leopold, 2013, Open J Cardiovasc Surg, V6, P9, DOI 10.4137/OJCS.S11199
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   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 10
TC 0
Z9 0
U1 0
U2 0
PU Annals Thoracic and Cardiovascular Surgery Editorial Office
PI Tokyo
PA International Academic Publishing Co., Ltd, c/o Publishing Center,
   Yamabuki-cho 332-6, Tokyo, Shinjuku-ku, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2026
VL 32
IS 1
AR 2600048
DI 10.5761/atcs.oa.26-00048
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JN5TS
UT WOS:001793569600001
PM 42289342
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, XY
   He, JQ
   Li, ZB
   Zhu, JY
   Wu, J
AF Wang, Xiaoyan
   He, Jinqing
   Li, Zhibin
   Zhu, Jiayuan
   Wu, Jun
TI The early association of water irrigation with negative pressure wound
   therapy does not more efficiently reduce the depth of the alkali
   infiltration progress into the burn
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE alkali burn; NPWT; water irrigation; wound healing
ID CHEMICAL BURNS; SKIN INJURIES
AB Water irrigation is an efficacious decontaminating method for dermis exposures to corrosive agents and hence has been widely applied to treat especially alkali burns. Nevertheless, once alkali has infiltrated the deep subcutaneous tissue, washing the tissue surface with water irrigation does not attenuate the damage progress. Therefore, significant efforts have been devoted to promising strategies aimed at removing the deeply infiltrated lye. According to a recent report, the negative pressure wound therapy (NPWT) reduces the pH value of the exudate from alkali-provoked burns thus accelerating wound healing. However, it remains to be ascertained whether or not NPWT coupled with water irrigation, that is, iNPWT, more effectively hinders the alkali injury deepening. In this study, we compared the effectiveness of an early application of water irrigation with or without NPWT in preventing the progressive deepening of the alkali burn in an animal model. Our histological examination results showed no appreciable difference in tissue injury depth, dermal retention, inflammatory cell infiltration, re-epithelization, and cellular function between iNPWT and water irrigation alone treatments. Thus, our results prove that the more expensive NPWT coupled with water irrigation does not more effectively hinder the alkali's injury deepening. Hence, iNPWT use should be more cautious in clinical practice.
C1 [Wang, Xiaoyan; Zhu, Jiayuan] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, Guangzhou, Peoples R China.
   [He, Jinqing; Li, Zhibin; Wu, Jun] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Burn & Plast Surg,Shenzhen Inst Translat Med, Shenzhen 518035, Guangdong, Peoples R China.
   [Wu, Jun] Univ Verona, Dept Surg Dent Paediat & Obstet, Sect Human Histol & Embryol, Verona, Venetia, Italy.
C3 Sun Yat Sen University; Shenzhen University; University of Verona
RP Wu, J (通讯作者)，Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Burn & Plast Surg,Shenzhen Inst Translat Med, Shenzhen 518035, Guangdong, Peoples R China.; Zhu, JY (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510000, Guangdong, Peoples R China.
EM zhujiay@mail.sysu.edu.cn; junwupro@126.com
RI Li, Zhibin/GQH-6384-2022; Wang, Xiaoyan/M-7442-2018
OI wu, jun/0000-0002-4997-1970
FU Guangdong Basic and Applied Basic Research Foundation [2020A1515010613,
   2021A1515220176]; Guangdong Medical Science and Technology Research
   Foundation [A2021077]; National Natural Science Foundation of China
   [82172214, 82072180]; Retired Expert Program of Guangdong Province
   [202020031911500002]; Shenzhen-Hong Kong-Macau Technology Research
   Programme [SGDX2020110309300301]; Key Basic Research Project of Shenzhen
   Science and Technology Program [JCYJ20200109115635440]
FX Guangdong Basic and Applied Basic Research Foundation, Grant/Award
   Numbers: 2020A1515010613, 2021A1515220176; Guangdong Medical Science and
   Technology Research Foundation, Grant/Award Number:A2021077; National
   Natural Science Foundation of China, Grant/Award Numbers: 82172214,
   82072180; Retired Expert Program of Guangdong Province, Grant/Award
   Number: 202020031911500002; Shenzhen-Hong Kong-Macau Technology Research
   Programme, Grant/Award Number: SGDX2020110309300301; the Key Basic
   Research Project of Shenzhen Science and Technology Program, Grant/Award
   Number: JCYJ20200109115635440
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NR 23
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2023
VL 20
IS 2
BP 351
EP 358
DI 10.1111/iwj.13883
EA JUL 2022
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8K9TL
UT WOS:000827292700001
PM 35854477
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yasuda, JL
   Svetanoff, WJ
   Staffa, SJ
   Zendejas, B
   Hamilton, TE
   Jennings, RW
   Ngo, PD
   Smithers, CJ
   Manfredi, MA
AF Yasuda, Jessica L.
   Svetanoff, Wendy Jo
   Staffa, Steven J.
   Zendejas, Benjamin
   Hamilton, Thomas E.
   Jennings, Russell W.
   Ngo, Peter D.
   Smithers, C. Jason
   Manfredi, Michael A.
TI Prophylactic negative vacuum therapy of high-risk esophageal anastomoses
   in pediatric patients
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE Esophageal atresia; Vacuum assisted closure; Evac; Esophageal leak
ID ATRESIA; REPAIR; STRICTURE; LONG; COMPLICATIONS; CHILDREN
AB Background: Esophageal anastomoses are at risk for leak or stricture. Negative pressure vacuum-assisted closure (VAC) therapy is used to treat leak. We hypothesized that a prophylactic VAC (pEVAC) at the time of new anastomosis may lead to fewer leaks and strictures.
   Methods: Single center retrospective case-control study of patients undergoing high-risk esophageal anastomoses between July 2015 and January 2019. Outcomes of leak and long-term anastomotic failure (refractory stricture requiring surgery) were compared between groups.
   Results: Sixteen patients had a pEVAC placed during LGEA repair ( N = 10) or stricture resection ( N = 6). Of pEVAC cases, 3 ( N = 1 Foker, N = 2 stricture resections) experienced leak (18.8%). In comparison, leak occurred in 9/41 (22%) Foker patients and in 1/20 (5%) stricture resections without pEVAC, all p > 0.05. Long-term anastomotic failure was more common in the pEVAC cohort versus controls (56.3% versus 11.5%, p < 0.001).
   Conclusions: Prophylactic EVAC placement does not appear to reduce leak and is associated with significantly greater odds of long-term anastomotic failure. Further device refinement could improve its potential role in prophylaxis of high-risk anastomoses, but future research is needed to better understand optimal patient selection, device design, and duration of pEVAC therapy. (C)& nbsp;2020 Elsevier Inc. All rights reserved.
C1 [Yasuda, Jessica L.; Ngo, Peter D.; Manfredi, Michael A.] Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, 300 Longwood Ave, Boston, MA 02115 USA.
   [Svetanoff, Wendy Jo; Zendejas, Benjamin; Hamilton, Thomas E.; Jennings, Russell W.; Smithers, C. Jason] Boston Childrens Hosp, Dept Gen Surg, Boston, MA USA.
   [Staffa, Steven J.] Boston Chilrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA.
   [Svetanoff, Wendy Jo] Childrens Mercy Kansas City, Dept Pediat Surg, Kansas City, MO USA.
   [Smithers, C. Jason] Johns Hopkins All Childrens Hosp, Dept Surg, St Petersburg, FL USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Children's Mercy Hospital; Johns
   Hopkins University; Johns Hopkins Medicine
RP Yasuda, JL (通讯作者)，Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, 300 Longwood Ave, Boston, MA 02115 USA.
RI ; Hamilton, Thomas/GQB-4837-2022
OI Jennings, Russell/0000-0002-0133-2707; 
CR [Anonymous], J PEDIATR GASTR NUTR
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   Neumann PA, 2017, ENDOSCOPY, V49, P498, DOI 10.1055/s-0042-123188
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NR 28
TC 9
Z9 10
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2021
VL 56
IS 5
BP 944
EP 950
DI 10.1016/j.jpedsurg.2020.12.002
EA MAY 2021
PG 7
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA SA9PS
UT WOS:000649635700021
PM 33342604
DA 2026-07-24
ER

PT J
AU Horta, R
   Nascimento, R
   Silva, M
   Amarante, J
AF Horta, Ricardo
   Nascimento, Ricardo
   Silva, Mdalvaro
   Amarante, Jose
TI The Free-style Gluteal Perforator Flap in the Thinning and Delay Process
   for Perineal Reconstruction After Necrotizing Fasciitis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE free-style; perforator flap; perineal reconstruction; necrotizing
   fasciitis
ID VACUUM-ASSISTED CLOSURE; BREAST RECONSTRUCTION; NEGATIVE-PRESSURE;
   DEFECTS; ARTERY; COMPLICATIONS; ELEVATION
AB Perineal wounds present a special Challenge for reconstructive surgeons. The vacuum-assisted closure device is useful as a temporizing measure or for wounds too large or contaminated for immediate reconstruction. Compared to traditional myocutaneous flaps, perforator flaps provide thinner fasciocutaneous flaps for perineal reconstruction with favorable results and fewer donor site morbidities. The upper and lower gluteal regions are rich in perforators, which allow for more versatile flap design according to the defect. The authors combined the principles of free-Style perforator flaps, flap delay, and thinning of perforator flaps to restore perineal function and aesthetics. The procedure was undertaken in a 72-year-old female who was Obese with the diagnosis of necrotizing fasciitis Secondary to perineal abscess. After 3 months, the flap achieved adequate and durable reconstruction with acceptable aesthetic contour and patient satisfaction; there was no loss of function at donor sites. Clinical applications and technical refinements of freestyle pedicled perforator flaps can be extended to the perineal region. Because of its many advantages and its versatility, freestyle pedicled perforator flaps constitute a valued reconstructive option and, when indicated, an alternative to pedicled axial flaps or even free flaps, in addition to vacuum therapy, to simplify the reconstructive procedure.
C1 [Horta, Ricardo; Nascimento, Ricardo; Silva, Mdalvaro; Amarante, Jose] Ctr Hosp Sao Joao, Dept Plast Reconstruct & Maxillofacial Surg & Bur, Oporto, Portugal.
C3 Sao Joao Hospital
RP Horta, R (通讯作者)，Ctr Hosp Sao Joao, Dept Plast Reconstruct & Maxillofacial Surg & Bur, Fac Med, Oporto, Portugal.
EM ricardojmhorta@gmail.com
RI ; Amarante, José Manuel/O-9050-2014
OI Horta, Ricardo/0000-0002-4658-1889; Amarante, José
   Manuel/0000-0003-4917-6915
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NR 28
TC 6
Z9 6
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2016
VL 28
IS 6
BP 200
EP 205
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DP5WJ
UT WOS:000378568600007
PM 27434419
DA 2026-07-24
ER

PT J
AU Poulakidas, S
   Cologne, K
   Kowa-Vern, A
AF Poulakidas, Stathis
   Cologne, Kyle
   Kowa-Vern, Areta
TI Treatment of Frostbite With Subatmospheric Pressure Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTREMITIES; AMPUTATION; STATE
AB Frostbite may result in loss of skin and tissue requiring amputation; it occurs most often on the exposed areas such as extremity, digits, ears, etc. The usual treatment is observation for demarcation of the injury before amputation or autoamputation of the dry gangrene that may set in between 1 and 3 weeks. In some instances, tissue viability is assessed by a pyrophosphate nuclear scan. This was a 43-year-old African-American man who developed frost-bite of his right foot. He presented 72 hours after injury with hyperemia and cellulitis over the dorsum of the foot and a blistered dorsal surface of the great toe with loss of sensation on all toes and early signs of necrosis. The patient received a 7-day course of ampicillin-sulbactam and a 6-day course of vacuum-assisted closure therapy during a 7-day hospitalization. At the time of discharge, lie had re-epithialialization of the dorsal surface of the right toe and healthy granulation tissue with islands of epidermis emerging on the ventral surface of the right toe. Re-epithelialization was complete by 26 days after injury. In the future, this treatment therapy may find a larger application in frostbite injuries because it may accelerate healing. A study of frostbite treatment confirming the usefulness of this modality may be indicated. (J Burn Care Res 2008;29:1012-1014)
C1 [Poulakidas, Stathis; Cologne, Kyle; Kowa-Vern, Areta] John H Stroger Jr Hosp Cook Cty, Dept Trauma, Sumner L Koch Burn Ctr, Chicago, IL USA.
C3 John H Stroger Junior Hospital Cook County; University of Illinois
   System; University of Illinois Chicago; University of Illinois Chicago
   Hospital
RP Poulakidas, S (通讯作者)，Sumner L Koch Burn Ctr, Room 3229,1901 W Harrison St, Chicago, IL 60612 USA.
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NR 25
TC 11
Z9 11
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD NOV-DEC
PY 2008
VL 29
IS 6
BP 1012
EP 1014
DI 10.1097/BCR.0b013e31818ba0ad
PG 3
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 372ZD
UT WOS:000260939900028
PM 18849842
DA 2026-07-24
ER

PT J
AU Swenne, CL
   Skytt, B
   Lindholm, C
   Carlsson, M
AF Swenne, C. L.
   Skytt, B.
   Lindholm, C.
   Carlsson, M.
TI Patients' experiences of mediastinitis after coronary artery bypass
   graft procedure
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE coronary artery by-pass; surgical wound infection; mediastinitis; vacuum
   assisted closure; psychology; quality of life
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; SURGERY; QUALITY; STRESS;
   INFECTION; CARE
AB Few studies have focussed on patients' experiences of and suffering due to mediastinitis following Coronary Artery by-pass Graft ( CABG). Mediastinitis creates a complex and invasive experience for the patient with prolonged hospitalisation, and would be expected to be a significant stressor. The aim of the present study was to capture patients' experiences of the medical and nursing care they received for mediastinitis following CABG. Content analysis revealed three themes with regard to how the patients coped with the stress and threats of mediastinitis and its treatment and how they thought it would influence their future life. A first theme centred on physical and psychological discomfort and impact on autonomy. The staff's medical knowledge and the quality of nursing care as well as the patients' understanding of the situation influenced their experience. A second theme was how patients dealt with perceived danger and stress. Coping strategies such as problem solving, information seeking, dissociation, distraction, minimisation and expression of emotion were used to handle the situations. The third theme comprised the patients' belief that the mediastinitis would not affect the outcome of the CABG procedure, even though their confidence in this was influenced by uncertainty about the rehabilitation process.
C1 Univ Uppsala Hosp, Dept Cardiothorac Surg, OTM Div, S-75185 Uppsala, Sweden.
   Dept Publ Hlth & Caring Sci, Uppsala Sci Pk, S-75185 Uppsala, Sweden.
   Uppsala Univ, Cty Council Gavleborg, Ctr Res & Dev, S-80188 Gavle, Sweden.
   Kristianstad Univ, Karolinska Inst, Dept Hlth Sci, Dept Surg Sci, S-29188 Kristianstad, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University;
   Uppsala University; Kristianstad University; Karolinska Institutet
RP Swenne, CL (通讯作者)，Univ Uppsala Hosp, Dept Cardiothorac Surg, OTM Div, 40,Str, S-75185 Uppsala, Sweden.
EM christine.leo.swenne@akademiska.se
RI Skytt, Bernice/AGR-4086-2022
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NR 23
TC 6
Z9 7
U1 0
U2 4
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2007
VL 41
IS 4
BP 255
EP 264
DI 10.1080/14017430701283856
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 197SS
UT WOS:000248577400008
PM 17680514
DA 2026-07-24
ER

PT J
AU Bingoel, AS
   Krezdorn, N
   Kaltenborn, A
   Dastagir, K
   Jokuszies, A
   Mett, TR
   Vogt, PM
AF Bingoel, Alperen S.
   Krezdorn, Nicco
   Kaltenborn, Alexander
   Dastagir, Khaled
   Jokuszies, Andreas
   Mett, Tobias R.
   Vogt, Peter M.
TI The surgical approach to Pyoderma gangrenosum: A retrospective
   monocenter study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE chronic wounds; negative pressure wound therapy; Pyoderma gangrenosum;
   skin grafting; wound healing
AB Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Nevertheless, surgical treatment might be necessary for reconstruction, once the progression of these wounds is controlled. We aimed to characterize medical findings in Pyoderma patients with extensive defects to assess the surgical procedures and their outcome. A retrospective study was conducted at our centre over an 18-year period. Inclusion criteria were the diagnosis of Pyoderma gangrenosum and at least one surgical intervention. Descriptive statistics were used to analyse the data. Sixteen patients were included. The mean size of the lesions was noted with 12 x 8 cm. Surgical procedures comprised debridements/necrectomies, allograft conditioning, negative pressure wound therapy, skin grafts, and microvascular free flaps. Seven patients were discharged with healed wounds, six with minor wound healing disturbances. Three patients succumbed to their underlying diseases. Drug-based therapy can stop the progress of Pyoderma, but severe tissue loss can be a persistent problem. According to our data, reconstructive-surgical treatments (debridement, autologous and allogenous skin transplantation and microvascular free flaps) act as an integral component of the therapy and can be safe options for selected patients. Furthermore, we provide an algorithm that we follow at our department in severe cases.
C1 [Bingoel, Alperen S.; Krezdorn, Nicco; Dastagir, Khaled; Jokuszies, Andreas; Mett, Tobias R.; Vogt, Peter M.] Hannover Med Sch, Burn Ctr, Dept Plast Aesthet Hand & Reconstruct Surg, Hannover, Germany.
   [Kaltenborn, Alexander] Armed Forces Hosp Westerstede, Dept Trauma & Orthoped Surg Plast Hand & Reconstr, Westerstede, Germany.
C3 Hannover Medical School
RP Bingoel, AS (通讯作者)，Hannover Med Sch, Dept Plast Aesthet Hand & Reconstruct Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM bingoel.alperen@mh-hannover.de
RI Vogt, Peter/AAL-1332-2020; Krezdorn, Nicco/AAP-6266-2021; Bingoel,
   Alperen Sabri/MHQ-0362-2025
OI Krezdorn, Nicco/0000-0003-2662-6290; Bingoel, Alperen
   Sabri/0000-0003-4057-0318
FU Projekt DEAL
FX The authors like to thank all of the patients for their excellent
   cooperation. Special thanks go to Nora Schaumann and Hinrich Freitag,
   Institute of Pathology of Hannover Medical School, for providing the
   histopathological images. Open access funding enabled and organized by
   Projekt DEAL.
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NR 40
TC 11
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2021
VL 29
IS 3
BP 478
EP 485
DI 10.1111/wrr.12918
EA APR 2021
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA SC5OP
UT WOS:000638268300001
PM 33835625
OA hybrid
DA 2026-07-24
ER

PT J
AU Armstrong, DG
   Kunze, K
   Martin, BR
   Kimbriel, HR
   Nixon, BP
   Boulton, AJM
AF Armstrong, DG
   Kunze, K
   Martin, BR
   Kimbriel, HR
   Nixon, BP
   Boulton, AJM
TI Plantar pressure changes using a novel negative pressure wound therapy
   technique
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID DIABETIC FOOT ULCERATION; RISK
AB This study evaluated changes in pressure imparted to diabetic foot wounds using a novel negative pressure bridging technique coupled with a robust removable cast walker. Ten patients had plantar pressures assessed with and without a bridged negative pressure dressing on the foot. Off-loading was accomplished with a pressure-relief walker. Plantar pressures were recorded using two pressure-measurement systems. The location and value of peak focal pressure (taken from six midgait steps) were recorded at the site of ulceration. Paired analysis revealed a large difference (mean +/- SD, 74.6% +/- 6.0%) between baseline barefoot pressure and pressure within the pressure-relief walker (mean +/- SD, 939.1 +/- 195.1 versus 235.7 +/- 66.1 kPa). There was a mean +/- SD 9.9% +/- 5.6% higher pressure in the combination device compared with the pressure-relief walker alone (mean +/- SD, 258.0 +/- 69.7 versus 235.7 66.1 kPa). This difference was only 2% of the initial barefoot pressure imparted to the wound. A modified negative pressure dressing coupled with a robust removable cast walker may not impart undue additional stress to the plantar aspect of the foot and may allow patients to retain some degree of freedom (and a potentially reduced length of hospital stay) while still allowing for the beneficial effects of negative pressure wound therapy and sufficient off-loading.
C1 Rosalind Franklin Univ Med & Sci, Dept Surg, Dr William M Scholl Coll Podiat Med, N Chicago, IL 60064 USA.
   So Arizona Affairs Med Ctr, Dept Surg, Podiatry Sect, Tucson, AZ USA.
   Univ Miami, Diabet Res Inst, Miami, FL 33152 USA.
   Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England.
C3 Rosalind Franklin University of Medicine & Science; University of Miami;
   University of Manchester
RP Armstrong, DG (通讯作者)，Rosalind Franklin Univ Med & Sci, Dept Surg, Dr William M Scholl Coll Podiat Med, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
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NR 13
TC 8
Z9 21
U1 0
U2 3
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2004
VL 94
IS 5
BP 456
EP 460
DI 10.7547/0940456
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 856XH
UT WOS:000224078800004
PM 15377721
DA 2026-07-24
ER

PT J
AU Cheng, Y
   Wang, K
   Gong, JH
   Liu, ZJ
   Gong, JP
   Zeng, Z
   Wang, XM
AF Cheng, Yao
   Wang, Ke
   Gong, Junhua
   Liu, Zuojin
   Gong, Jianping
   Zeng, Zhong
   Wang, Xiaomei
TI Negative pressure wound therapy for managing the open abdomen in
   non-trauma patients
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID TEMPORARY ABDOMINAL CLOSURE; MEDIATED FASCIAL TRACTION;
   PROGNOSTIC-FACTORS; DELAYED CLOSURE; SEPTIC PATIENTS; MANAGEMENT;
   VACUUM; SURGERY; RECOMMENDATIONS; METAANALYSIS
AB Background
   Management of the open abdomen is a considerable burden for patients and healthcare professionals. Various temporary abdominal closure techniques have been suggested for managing the open abdomen. In recent years, negative pressure wound therapy (NPWT) has been used in some centres for the treatment of non-trauma patients with an open abdomen; however, its effectiveness is uncertain.
   Objectives
   To assess the effects of negative pressure wound therapy (NPWT) on primary fascial closure for managing the open abdomen in non-trauma patients in any care setting.
   Search methods
   In October 2021 we searched the Cochrane Wounds Specialised Register, CENTRAL, MEDLINE, Embase, and CINAHL EBSCO Plus. To identify additional studies, we also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses, and health technology reports. There were no restrictions with respect to language, date of publication, or study setting.
   Selection criteria
   We included all randomised controlled trials (RCTs) that compared NPWT with any other type of temporary abdominal closure (e.g. Bogota bag, Wittmann patch) in non-trauma patients with open abdomen in any care setting. We also included RCTs that compared different types of NPWT systems for managing the open abdomen in non-trauma patients.
   Data collection and analysis
   Two review authors independently performed the study selection process, risk of bias assessment, data extraction, and GRADE assessment of the certainty of evidence.
   Main results
   We included two studies, involving 74 adults with open abdomen associated with various conditions, predominantly severe peritonitis (N = 55). The mean age of the participants was 52.8 years; the mean proportion of women was 39.2%. Both RCTs were carried out in single centres and were at high risk of bias.
   Negative pressure wound therapy versus Bogota bag
   We included one study (40 participants) comparing NPWT with Bogota bag. We are uncertain whether NPWT reduces time to primary fascial closure of the abdomen (NPWT: 16.9 days versus Bogota bag: 20.5 days (mean difference (MD) -3.60 days, 95% confidence interval (CI) -8.16 to 0.96); very low-certainty evidence) or adverse events (fistulae formation, NPWT: 10% versus Bogota: 5% (risk ratio (RR) 2.00, 95% CI 0.20 to 20.33); very low-certainty evidence) compared with the Bogota bag. We are also uncertain whether NPWT reduces all-cause mortality (NPWT: 25% versus Bogota bag: 35% (RR 0.71, 95% CI 0.27 to 1.88); very low-certainty evidence) or length of hospital stay compared with the Bogota bag (NPWT mean: 28.5 days versus Bogota bag mean: 27.4 days (MD 1.10 days, 95% CI -13.39 to 15.59); very low-certainty evidence). The study did not report the proportion of participants with successful primary fascial closure of the abdomen, participant health-related quality of life, reoperation rate, wound infection, or pain.
   Negative pressure wound therapy versus any other type of temporary abdominal closure
   There were no randomised controlled trials comparing NPWT with any other type of temporary abdominal closure.
   Comparison of different negative pressure wound therapy devices
   We included one study (34 participants) comparing different types of NPWT systems (Suprasorb CNP system versus ABThera system). We are uncertain whether the Suprasorb CNP system increases the proportion of participants with successful primary fascial closure of the abdomen compared with the ABThera system (Suprasorb CNP system: 88.2% versus ABThera system: 70.6% (RR 0.80, 95% CI 0.56 to 1.14); very low-certainty evidence). We are also uncertain whether the Suprasorb CNP system reduces adverse events (fistulae formation, Suprasorb CNP system: 0% versus ABThera system: 23.5% (RR 0.11, 95% CI 0.01 to 1.92); very low-certainty evidence), all-cause mortality (Suprasorb CNP system: 5.9% versus ABThera system: 17.6% (RR 0.33, 95% CI 0.04 to 2.89); very low-certainty evidence), or reoperation rate compared with the ABThera system (Suprasorb CNP system: 100% versus ABThera system: 100% (RR 1.00, 95% CI 0.90 to 1.12); very low-certainty evidence). The study did not report the time to primary fascial closure of the abdomen, participant health-related quality of life, length of hospital stay, wound infection, or pain.
   Authors' conclusions
   Based on the available trial data, we are uncertain whether NPWT has any benefit in primary fascial closure of the abdomen, adverse events (fistulae formation), all-cause mortality, or length of hospital stay compared with the Bogota bag. We are also uncertain whether the Suprasorb CNP system has any benefit in primary fascial closure of the abdomen, adverse events, all-cause mortality, or reoperation rate compared with the ABThera system. Further research evaluating these outcomes as well as participant health-related quality of life, wound infection, and pain outcomes is required. We will update this review when data from the large studies that are currently ongoing are available.
C1 [Cheng, Yao; Wang, Ke; Liu, Zuojin; Gong, Jianping; Wang, Xiaomei] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China.
   [Gong, Junhua; Zeng, Zhong] Kunming Med Univ, Organ Transplant Ctr, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
C3 Chongqing Medical University; Kunming Medical University
RP Wang, XM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing, Peoples R China.
EM 300394@hospital.cqmu.edu.cn
RI ; gong, junhua/HTO-5296-2023
OI Gong, Junhua/0009-0003-2245-9007; 
FU National Institute for Health Research (NIHR), UK; National Institute
   for Health Research
FX The National Institute for Health Research (NIHR), UK This project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure funding to Cochrane Wounds. The views expressed are those
   of the authors and not necessarily those of the NIHR or the Department
   of Health and Social Care.
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NR 74
TC 13
Z9 25
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2022
IS 5
AR CD013710
DI 10.1002/14651858.CD013710.pub2
PG 41
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1S5YF
UT WOS:000804126100010
PM 35514120
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Tan, KJ
   Lim, CT
   Lim, AYT
AF Tan, K. -J.
   Lim, C. -T.
   Lim, A. Y. -T.
TI The use of muscle flaps in the salvage of infected exposed implants for
   internal fixation
SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TOTAL-HIP-ARTHROPLASTY; SPINAL INSTRUMENTATION;
   CLINICAL CORRELATION; MANAGEMENT; WOUNDS; FRACTURES; COVERAGE; BIOFILM
AB The treatment of infected exposed implants which have been used for internal fixation usually involves debridement and removal of the implant. This can result in an unstable fracture or spinal column. Muscle flaps may be used to salvage these implants since they provide soft-tissue cover and fresh vascularity. However, there have been few reports concerning their use and these have concentrated on the eradication of the infection and successful soft-tissue cover as the endpoint. There is no information on the factors which may influence the successful salvage of the implant using muscle flaps.
   We studied the results and factors affecting outcome in nine pedicled muscle flaps used in the treatment of exposed metal internal fixation with salvage of the implant as the primary endpoint. This was achieved in four cases. Factors predicting success were age < 30 years, the absence of comorbid conditions and a favourable microbiological profile. The growth of multiple organisms, a history of smoking and the presence of methicillin-resistant Staphylococcus aureus on wound cultures indicated a poor outcome. The use of antibiotic beads, vacuum-assisted closure and dressing, the surgical site, the type of flap performed and the time from primary surgery to flap cover were not predictive of outcome.
C1 [Tan, K. -J.; Lim, C. -T.; Lim, A. Y. -T.] Natl Univ Singapore, Univ Orthopaed,Natl Univ Hosp, Hand & Reconstruct Microsurg Cluster, Young Loo Lin Sch Med,Natl Univ Hlth Syst, Singapore 119074, Singapore.
C3 National University of Singapore
RP Lim, AYT (通讯作者)，Natl Univ Singapore, Univ Orthopaed,Natl Univ Hosp, Hand & Reconstruct Microsurg Cluster, Young Loo Lin Sch Med,Natl Univ Hlth Syst, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
EM aymeric_yt_lim@nuhs.cdu.sg
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NR 18
TC 27
Z9 29
U1 0
U2 2
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 0301-620X
J9 J BONE JOINT SURG BR
JI J. Bone Joint Surg.-Br. Vol.
PD MAR
PY 2010
VL 92B
IS 3
BP 401
EP 405
DI 10.1302/0301-620X.92B3.22115
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 561UW
UT WOS:000275006000013
PM 20190312
OA Bronze
DA 2026-07-24
ER

PT J
AU Langfitt, M
   Webb, LX
   Onwuchuruba, C
   Callahan, M
   Smith, TL
AF Langfitt, Maxwell
   Webb, Lawrence X.
   Onwuchuruba, Cheryl
   Callahan, Michael
   Smith, Thomas L.
TI Microvascular Effects of Subatmospheric Pressure in Striated Muscle
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE topical subatmospheric pressure; vasodilation; blood flow;
   vacuum-assisted closure; microvascular permeability
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BLOOD-FLOW; DEVICE
AB Objective Topical application of subatmospheric pressure (TASAP) promotes faster wound healing, but tissue effects are not entirely understood. This study investigated microvascular effects of TASAP in striated muscle with the hypothesis being that TASAP elicits arteriolar vasodilation and decreases interstitial accumulation of protein.
   Methods Rat cremasteric microcirculation was directly examined in two experiments utilizing a novel technique. First, TASAP was applied to the cremaster in three experimental groups and a non-TASAP control group. Arteriolar diameters were directly measured before and after TASAP. In experiment two, intravascular fluorescein isothiocyanate (FITC)-labeled albumin and topical leukotriene B-4 (LTB4) were delivered to the cremaster. Microvascular permeability was assessed by measuring the accumulation/ disappearance of FITC-albumin in the interstitial tissue.
   Results TASAP produced significant arteriolar vasodilation compared with control values. The mean maximum percent increase in diameter with TASAP was 8.70% at -2 kPa (p < 0.05), 7.16% at -4 kPa (p < 0.05), and 10.43% at -6 kPa (p < 0.01). TASAP decreased interstitial FITC-albumin by 26.3% (p < 0.008) following LTB4; the control group showed a steady increase in interstitial FITC-albumin.
   Conclusions These results support the hypothesis that TASAP elicits significant arteriolar vasodilation with a subsequent increase in blood flow as well as a decrease in interstitial protein accumulation.
C1 [Smith, Thomas L.] Wake Forest Univ, Baptist Med Ctr, Dept Orthopaed Surg, Sch Med, Winston Salem, NC 27157 USA.
   [Webb, Lawrence X.] Mercer Univ, Sch Med, Dept Orthopaed Surg, Macon, GA 31207 USA.
   [Onwuchuruba, Cheryl] Univ Tennessee, Sch Med, Dept Orthoped Surg, Knoxville, TN USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Mercer
   University; University of Tennessee System; University of Tennessee
   Health Science Center
RP Smith, TL (通讯作者)，Wake Forest Univ, Baptist Med Ctr, Dept Orthopaed Surg, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM tsmith@wakehealth.edu
FU NIH [5 T32HL007115-27, 5 T32HL007115-28]
FX Supported in part by the NIH Short TermResearch Training of Medical
   Students grant 5 T32HL007115-27, (M. Langfitt), 5 T32HL007115-28 (C.
   Onwuchuruba).
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   Wiig H, 2003, ACTA ANAESTH SCAND, V47, P111, DOI 10.1034/j.1399-6576.2003.00050.x
NR 24
TC 3
Z9 4
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD FEB
PY 2013
VL 29
IS 2
BP 117
EP 123
DI 10.1055/s-0032-1329924
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 078AH
UT WOS:000314070000007
PM 23292989
DA 2026-07-24
ER

PT J
AU Rhode, JM
   Burke, WM
   Cederna, PS
   Haefner, HK
AF Rhode, Jennifer M.
   Burke, William M.
   Cederna, Paul S.
   Haefner, Hope K.
TI Outcomes of surgical management of stage III vulvar hidradenitis
   suppurativa
SO JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article; Proceedings Paper
CT 19th World Congress of the
   International-Society-for-the-Study-of-Vulvovaginal-Disease
CY JUL 28-AUG 04, 2007
CL Juneau, AK
SP Int Soc Study Vulvovaginal Dis
DE hidradenitis suppurativa; skin graft; vulvar diseases; vulvectomy
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE DRESSINGS; CARBON-DIOXIDE
   LASER; SUBATMOSPHERIC PRESSURE; SKIN-GRAFTS; 10-YEAR EXPERIENCE; WOUND
   CONTROL; EXCISION; INFLIXIMAB; PATHOGENESIS
AB OBJECTIVE: To review prior experiences and outcomes of patients treated for stage III vulvar hidradenitis suppurativa (HS) and determine postoperative patient satisfaction.
   STUDY DESIGN. Patients managed surgically for stage III vulvar HS at University of Michigan Health Systems (January 2000 to December 2005) were identified. Retrospective record review was undertaken and data collected. Five met study criteria. All underwent radical vulvectomy to excise the HS. Most required extensive excision of the vulva, including mons, perianal area and buttock. One surgical defect was allowed to heal by secondary intention; all others underwent interval closure with split-thickness skin grafting (STSG). After debridement, all wounds were dressed with a vacuum assisted closure device.
   RESULTS: Of the 5 patients, 4 were satisfied with their outcome. The patient managed without STSG developed an introital stricture and was the only patient regretting undergoing surgical excision of the hidradenitis suppurativa. Some amount of depression was present in all patients postoperatively. Four were happy with the surgery; 3 said they would undergo surgery again.
   CONCLUSION: Patients with severe HS often require radical excision. Data conflict regarding optimal surgical management. Our experience supports good outcome in patients managed with radical excision and STSG.
C1 Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA.
   Columbia Univ, Med Ctr, Dept Obstet & Gynecol, New York, NY USA.
   Wright Patterson Med Ctr, Dept Obstet & Gynecol, Wright Patterson AFB, OH USA.
C3 University of Michigan System; University of Michigan; Columbia
   University
RP Haefner, HK (通讯作者)，Univ Michigan, Med Ctr, Womens Hosp L 4000, Dept Obstet & Gynecol, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM haefner@med.umich.edu
RI Burke, William/AAI-9265-2020
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NR 58
TC 19
Z9 20
U1 0
U2 2
PU SCI PRINTERS & PUBL INC
PI ST LOUIS
PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA
SN 0024-7758
EI 1943-3565
J9 J REPROD MED
JI J. Reprod. Med.
PD JUN
PY 2008
VL 53
IS 6
BP 420
EP 428
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology
GA 317NC
UT WOS:000257025900009
PM 18664060
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Timofte, DV
   Ludusanu, A
   Corlade-Andrei, M
   Ciuntu, RE
   Abdulan, IM
   Zamfir, AS
   Tanevski, A
   Maxim, M
   Balan, G
   Bordianu, A
   Cobzeanu, B
AF Ciuntu, Bogdan-Mihnea
   Timofte, Daniel Vasile
   Ludusanu, Andreea
   Corlade-Andrei, Mihaela
   Ciuntu, Roxana Elena
   Abdulan, Irina Mihaela
   Zamfir, Alexandra-Simona
   Tanevski, Adelina
   Maxim, Madalina
   Balan, Gheorghe
   Bordianu, Anca
   Cobzeanu, Bogdan
TI Adaptation of Endoluminal Vacuum Therapy via Extra-Luminal Access in the
   Treatment of a High Pharyngeal Fistula: Technical Feasibility and
   Outcome
SO LIFE-BASEL
LA English
DT Article
DE piriform sinus; perforation; mediastinitis; dental prosthesis ingestion;
   EVAC; deep neck infection; foreign body; sepsis; tracheostomy
ID MANAGEMENT; CLOSURE
AB Background: Perforation of the piriform sinus is a rare but severe clinical event that can lead to cervico-thoracic mediastinitis, a life-threatening condition requiring urgent multidisciplinary intervention. Among its etiologies, accidental ingestion of foreign bodies, including dental prostheses, is uncommon but poses significant risks due to the anatomical vulnerability of the hypopharyngeal structures. Methods: We report a rare case of right piriform sinus perforation secondary to the ingestion of a dental prosthesis, complicated by cervico-mediastinitis, sepsis, tracheostomy, and sacral pressure ulcer. The clinical course required emergency surgical intervention and intensive supportive care. Results: A novel aspect of this case was the use of the Endoscopic Vacuum-Assisted Closure (EVAC) irrigation system as an adjunctive technique in the management of deep cervical drainage. Rather than approaching the fistula from within the lumen, the team created a controlled external drainage system, adaptation of the vacuum-assisted closure therapy directly over the fistulous tract. Conclusions: This case highlights the importance of early diagnosis, high clinical suspicion and coordinated management in the treatment of piriform sinus perforations. It also illustrates the potential applicability of modern technologies such as negative pressure irrigation in the complex management of deep neck infections and mediastinitis.
C1 [Ciuntu, Bogdan-Mihnea; Timofte, Daniel Vasile; Ludusanu, Andreea; Tanevski, Adelina; Maxim, Madalina] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Gen Surg, 16 Univ St, Iasi 700115, Romania.
   [Ciuntu, Bogdan-Mihnea; Timofte, Daniel Vasile; Ludusanu, Andreea; Tanevski, Adelina; Maxim, Madalina] St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
   [Corlade-Andrei, Mihaela] Grigore T Popa Univ Med & Pharm, Dept Emergency Med Surg 2, Iasi 700115, Romania.
   [Ciuntu, Roxana Elena] Grigore T Popa Univ Med & Pharm, Dept Ophtalmol, 16 Univ St, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Zamfir, Alexandra-Simona] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Iasi 700115, Romania.
   [Balan, Gheorghe] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Bordianu, Anca] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Vasc Surg, 16 Univ St, Iasi 700115, Romania.
   [Cobzeanu, Bogdan] Grigore T Popa Univ Med & Pharm, ENT Clin Dept, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy
RP Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; dantimofte@yahoo.com;
   andreealudusanu1106@yahoo.com; mihaela.corlade2@umfiasi.ro;
   roxana-elena.ciuntu@umfiasi.ro; irina.abdulan@yahoo.com;
   gheorghe-g-balan@umfiasi.ro; bordianu.anca@d.umfiasi.ro;
   bogdan788@yahoo.com
RI Timofte, Daniel/AAE-2511-2019; Ludușanu, Andreea/IAP-8113-2023;
   Cobzeanu, Mihail/MSZ-4618-2025; Tanevski, Adelina/LUZ-8095-2024;
   /AAS-5572-2020; Balan, Gheorghe/OZF-7157-2025; Corlade-Andrei,
   Mihaela/HGB-3725-2022; Abdulan, Irina/AAA-3089-2020; Ciuntu,
   Bogdan/MTF-9477-2025; Zamfir, Alexandra-Simona/HNR-0426-2023
OI Timofte, Daniel/0000-0002-6604-874X; Ludușanu,
   Andreea/0009-0003-1785-5785; 
CR Abdulsada Mustafa, 2020, VideoGIE, V5, P8, DOI [10.1016/j.vgie.2019.10.004, 10.1016/j.vgie.2019.10.004]
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NR 24
TC 0
Z9 0
U1 4
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT 23
PY 2025
VL 15
IS 11
AR 1660
DI 10.3390/life15111660
PG 9
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA G5765
UT WOS:001624681500001
PM 41302085
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Summer, T
   Bota, O
   Armbruster, R
   Münchow, S
   Dragu, A
AF Summer, T.
   Bota, O.
   Armbruster, R.
   Muenchow, S.
   Dragu, A.
TI Soft tissue defects following tumor resection in the limbs and trunk
   Plastic reconstructive soft tissue and revision concepts
SO ORTHOPADE
LA German
DT Article
DE Plastic surgery; Reconstructive surgery; Microsurgery; Oncology;
   Vacuum-assisted closure
ID MICROSURGICAL RECONSTRUCTION; RESTORATION
AB Background Tissue defects of the trunk and limbs after oncologic surgery and radiation require plastic reconstructive tissue coverage. Depending on the location and size of the wound as well as the interdisciplinary treatment concept, different reconstructive procedures are performed. These range from skin transplantation to local and pedicle flaps, to perforator flaps and free microsurgical tissue transfer. Methods The modern "reconstructive ladder" can be regarded as an orientation for the sequence of the reconstructive options. Considering the patient's wishes and risk profile, an individual reconstructive concept must be devised. The best functional and simultaneously safest procedure with the smallest secondary defect is to be chosen. Wound preconditioning via vacuum-assisted closure can precede definitive tissue coverage in order to optimize local conditions. Conclusion Safe tissue coverage can be achieved even in advanced stages of oncologic disease and after extensive surgery by performing wound preconditioning and arteriovenous loop grafting to induce safe de novo recipient vessels for two-stage free tissue transfer. The choice between maximum plastic reconstructive options for a curative approach or limited palliative surgery is to be harmonized and balanced with therapeutic goals and the patient's biologic resources. Preservation and restoration of quality of life and functionality is the plastic surgeon's dictum.
C1 [Summer, T.; Bota, O.; Armbruster, R.; Muenchow, S.; Dragu, A.] Tech Univ Dresden, Univ Ctr Orthopadie & Unfallchirurg, Univ Klinikum Carl Gustav Carus, Abt Plast & Handchirurg, Fetscherstr 74, DE-01307 Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Summer, T (通讯作者)，Tech Univ Dresden, Univ Ctr Orthopadie & Unfallchirurg, Univ Klinikum Carl Gustav Carus, Abt Plast & Handchirurg, Fetscherstr 74, DE-01307 Dresden, Germany.
EM tobias.summer@uniklinikum-dresden.de
RI Dragu, Adrian/AAH-3506-2019; Bota, Olimpiu/AAN-4292-2021
OI Dragu, Adrian/0000-0003-4633-2695; Bota, Olimpiu/0000-0002-5836-1269
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NR 30
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0085-4530
EI 1433-0431
J9 ORTHOPADE
JI Orthopade
PD FEB
PY 2020
VL 49
IS 2
SI SI
BP 169
EP 176
DI 10.1007/s00132-020-03871-2
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA KN0MX
UT WOS:000514534300011
PM 31974632
DA 2026-07-24
ER

PT J
AU Glicenstein, J
AF Glicenstein, J.
TI Jules!Guerin (1801-1885) and wounds pneumatic occlusion.: A precursor of
   VAC®
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE wound treatment; wound dressing; history
ID VACUUM-ASSISTED CLOSURE
AB Vacuum-Assisted Closure System (R) (V.A.C.(R)), tested and introduced by MJ Morykwas and LC Argenta in 1977, is a wide-spread procedure used for the treatment of defects and chronic wounds. In the middle of the 19th century, a French surgeon tried hopelessly to convince the medical authorities by that time of the interest of a similar method. In 1844, Jules Guerin (1801-1885) imagined a process and described the technique and the results in the prestigious Academy of Medicine and Sciences in Paris in 1866 and 1867. Jules Guerin proposed to treat chronic wounds and defects by what he called "pneumatic occlusion". He proposed an apparatus with three parts: a process dressing applied to be wound a rubber occlusive membrane linked to an empty bell with a manometer. Jules Guerin presented his method with the indications, severed times at the Academy of Medicine. Results were detailed on complex wounds or amputations strumps. He explained with detail the action of the pneumatic occlusion but without taking on to account the role microorganisms and the absence of hygiene in infections. Unfortunately for him, his presentations were contemporary to the works of Pasteur and Lister. All surgeons privileged the use of antiseptics on wounds. The works of Jules Guerin were forgotten.(c) 2008 Elsevier Masson SAS.
RP Glicenstein, J (通讯作者)，63 Blvd Invalides, F-75007 Paris, France.
EM jglicenstein@free.fr
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NR 17
TC 1
Z9 4
U1 0
U2 0
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD AUG
PY 2008
VL 53
IS 4
BP 378
EP 382
DI 10.1016/j.anplas.2007.12.002
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 334DF
UT WOS:000258201800012
PM 18395314
DA 2026-07-24
ER

PT J
AU Luo, J
   Yao, HL
   Lei, SL
   Xie, Y
AF Luo, Jing
   Yao, Hongliang
   Lei, Sanlin
   Xie, Yong
TI Recurrent pelvic stromal tumor with colon fistula of left leg: a case
   report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Gastrointestinal stromal tumors; colon fistula of left leg; sunitinib;
   case report; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; IMATINIB MESYLATE; ADJUVANT IMATINIB; WOUNDS;
   TRIAL; DIAGNOSIS; PRESSURE
AB The oral tyrosine kinase inhibitor (TKI), sunitinib malate, has been widely used in patients with gastroin-testinal stromal tumors (GISTs). The formation of colon fistula of left leg during treatment with sunitinib for recurrent pelvic stromal tumor has not been described before. We describe a 47 years old man who had received several surgical resections and taken imatinib mesylate due to recurrent gastrointestinal stromal tumors. Recently, in consideration of imatinib resistance, the patient changed the drug from imatinib to sunitinib. Unfortunately, a fistula developed between the sigmoid colon cavity and the left leg skin. Thus, the patient received surgery under general anesthesia after active nutrition support therapy and the vacuum assisted closuretherapy was taken to promote wound healing and avoid skin grafting or reduce the grafting area. Finally, the patient was discharged with a better health condition without skin grafting. This is the first description of recurrent pelvic stromal tumor with colon fistula of left leg under sunitinib treatment. From this case, clinicians should raise awareness of the possibility of intestinal perforation and enterocutaneous fistula for patients with gastrointestinal stromal tumors, especially when the intestine is involved by tumor and under the treatment of molecular targeted drugs.
C1 [Luo, Jing; Yao, Hongliang; Lei, Sanlin; Xie, Yong] Cent S Univ, Xiangya Hosp 2, Dept Gastrointestinal Surg, Renmin Rd, Changsha 410011, Hunan, Peoples R China.
C3 Central South University
RP Yao, HL (通讯作者)，Cent S Univ, Xiangya Hosp 2, Dept Gastrointestinal Surg, Renmin Rd, Changsha 410011, Hunan, Peoples R China.
EM yaohl0326@csu.edu.cn
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NR 26
TC 0
Z9 1
U1 0
U2 11
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 10
BP 14813
EP 14820
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FL5QD
UT WOS:000414299700080
DA 2026-07-24
ER

PT J
AU Erba, P
   Adini, A
   Demcheva, M
   Valeri, CR
   Orgill, DP
AF Erba, Paolo
   Adini, Avner
   Demcheva, Marina
   Valeri, C. Robert
   Orgill, Dennis P.
TI Poly-N-Acetyl Glucosamine Fibers Are Synergistic With
   Vacuum-Assisted Closure in Augmenting the Healing Response of Diabetic
   Mice
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Poly-N-acetyl glucosamine fibers; VAC; Wound healing; Diabetic mice
ID WOUND THERAPY; BANDAGE; CULTURE; LOAD
AB Background: Vacuum-assisted closure (VAC) has become the preferred modality to treat many complex wounds but could be further improved by methods that minimize bleeding and facilitate wound epithelialization. Short fiber poly-N-acetyl glucosamine nanofibers (sNAG) are effective hemostatic agents that activate platelets and facilitate wound epithelialization. We hypothesized that sNAG used in combination with the VAC device could be synergistic in promoting wound healing while minimizing the risk of bleeding.
   Methods: Membranes consisting entirely of sNAG nanofibers were applied immediately to dorsal excisional wounds of db/db mice followed by application of the VAC device. Wound healing kinetics, angiogenesis, and wound-related growth factor expression were measured.
   Results: The application of sNAG membranes to wounds 24 hours before application of the VAC device was associated with a significant activation of wounds (expression of PDGF, TGF beta, EGF), superior granulation tissue formation rich in Collagen I as well as superior wound epithelialization (8.6% +/- 0.3% vs. 1.8% +/- 1.1% of initial wound size) and wound contraction.
   Conclusions: The application of sNAG fiber-containing membranes before the application of the polyurethane foam interface of VAC devices leads to superior healing in db/db mice and represents a promising wound healing adjunct that can also reduce the risk of bleeding complications.
C1 [Erba, Paolo] Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Erba, Paolo] Univ Lausanne Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Adini, Avner] Harvard Univ, Childrens Hosp, Sch Med, Vasc Biol Program,Dept Surg, Boston, MA 02115 USA.
   [Orgill, Dennis P.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast Surg, Boston, MA 02115 USA.
   [Demcheva, Marina] Marine Polymer Technol, Danvers, MA USA.
   [Valeri, C. Robert] USN, Blood Res Lab Inc, Boston, MA USA.
C3 University of Basel; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; United States Department of Defense;
   United States Navy
RP Erba, P (通讯作者)，Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
EM erbapaolo@hotmail.com
RI Adini, Avner/AAD-6141-2022; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
FU Marine Polymer Technologies, Inc., Danvers, MA; Marine Polymers, Inc.;
   Kinetic Concepts Inc. (KCI)
FX The Tissue Engineering and Wound Healing Laboratory at Brigham and
   Women's Hospital acknowledges Marine Polymer Technologies, Inc.,
   Danvers, MA, for their material and financial support of this project.
   Supported, in part, by a research contract from Marine Polymers, Inc. to
   Brigham and Women's Hospital. During the time of the experiment, Dr.
   Orgill was a principal investigator for a research study funded by
   Kinetic Concepts Inc. (KCI) to Brigham and Women's Hospital.
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NR 22
TC 9
Z9 10
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 1
BP S187
EP S193
DI 10.1097/TA.0b013e318225583c
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806WZ
UT WOS:000293849000007
PM 21814117
DA 2026-07-24
ER

PT J
AU Al-Mufarrej, F
   Margolis, M
   Tempesta, B
   Strother, E
   Gharagozloo, F
AF Al-Mufarrej, Faisal
   Margolis, Marc
   Tempesta, Barbara
   Strother, Eric
   Gharagozloo, Farid
TI Outpatient Management of Post-Pneumonectomy and Post-Lobectomy Empyema
   Using the Vacuum-Assisted Closure System
SO SURGERY TODAY
LA English
DT Article
DE Vacuum-assisted closure; Empyema; Pneumonectomy
ID WOUNDS; DEVICE
AB The goal of this study was to analyze the patterns, therapeutic modalities, and short-term outcomes of patients with chest injuries in the aftermath of the Wen-Chuan earthquake, which occurred on May 12, 2008 and registered 8.0 on the Richter scale.
   Of the 1522 patients who were referred to the West China Hospital of Sichuan University from May 12 to May 27, 169 patients (11.1%) had suffered major chest injuries. The type of injury, the presence of infection, Abbreviated Injury Score (AIS 2005), New Injury Severity Score (NISS), treatment, and short-term outcome were all documented for each case.
   Isolated chest injuries were diagnosed in 129 patients (76.3%), while multiple injuries with a major chest trauma were diagnosed in 40 patients (23.7%). The mean AIS and the median NISS of the hospitalized patients with chest injuries were 2.5 and 13, respectively. The mortality rate was 3.0% (5 patients).
   Most of the chest injuries were classified as minor to moderate trauma; however, coexistent multiple injuries and subsequent infection should be carefully considered in medical response strategies. Coordinated efforts among emergency medical support groups and prior training in earthquake preparedness and rescue in earthquake-prone areas are therefore necessary for efficient evacuation and treatment of catastrophic casualties.
C1 [Al-Mufarrej, Faisal; Margolis, Marc; Strother, Eric; Gharagozloo, Farid] George Washington Univ, Med Ctr, Washington, DC 20037 USA.
   [Margolis, Marc; Tempesta, Barbara; Gharagozloo, Farid] Washington Inst Thorac & Cardiovasc Surg, Washington, DC USA.
C3 George Washington University
RP Al-Mufarrej, F (通讯作者)，George Washington Univ, Med Ctr, 2300 Eye St NW, Washington, DC 20037 USA.
CR Matzi V, 2007, ANN THORAC SURG, V84, P1762, DOI 10.1016/j.athoracsur.2007.05.052
   Morykwas M. J., 1997, ANN PLAST SURG, V38, P563
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
NR 6
TC 14
Z9 16
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
J9 SURG TODAY
JI Surg. Today
PD AUG
PY 2010
VL 40
IS 8
BP 711
EP 718
DI 10.1007/s00595-008-4096-9
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 634KI
UT WOS:000280579400005
PM 20676853
DA 2026-07-24
ER

PT J
AU Saxena, V
   Orgill, D
   Kohane, I
AF Saxena, Vishal
   Orgill, Dennis
   Kohane, Isaac
TI A set of genes previously implicated in the hypoxia response might be an
   important modulator in the rat ear tissue response to mechanical stretch
SO BMC GENOMICS
LA English
DT Article
ID HEME OXYGENASE-1 GENE; VACUUM-ASSISTED CLOSURE; NITRIC-OXIDE SYNTHASE;
   OXIDATIVE STRESS; OVEREXPRESSION; EXPRESSION; INDUCTION; PROTECTS;
   MUSCLE
AB Background: Wounds are increasingly important in our aging societies. Pathologies such as diabetes predispose patients to chronic wounds that can cause pain, infection, and amputation. The vacuum assisted closure device shows remarkable outcomes in wound healing. Its mechanism of action is unclear despite several hypotheses advanced. We previously hypothesized that micromechanical forces can heal wounds. To understand better the biological response of soft tissue to forces, rat ears in vivo were stretched and their gene expression patterns over time obtained. The absolute enrichment (AE) algorithm that obtains a combined up and down regulated picture of the expression analysis was implemented.
   Results: With the use of AE, the hypoxia gene set was the most important at a highly significant level. A co-expression network analysis showed that important co-regulated members of the hypoxia pathway include a glucose transporter (slc2a8), heme oxygenase, and nitric oxide synthase2 among others.
   Conclusion: It appears that the hypoxia pathway may be an important modulator of response of soft tissue to forces. This finding gives us insights not only into the underlying biology, but also into clinical interventions that could be designed to mimic within wounded tissue the effects of forces without all the negative effects that forces themselves create.
C1 [Saxena, Vishal; Orgill, Dennis] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Saxena, Vishal; Orgill, Dennis; Kohane, Isaac] Harvard Med Sch, Boston, MA USA.
   [Kohane, Isaac] Childrens Hosp, Childrens Hosp Informat Program, Boston, MA 02115 USA.
   [Kohane, Isaac] MIT, HST, Cambridge, MA 02139 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Massachusetts Institute of Technology (MIT)
RP Saxena, V (通讯作者)，Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
EM vishal@mit.edu; dorgill@partners.org; isaac_kohane@harvard.edu
RI Orgill, Dennis/H-7596-2019; kohane, Isaac/IQW-2413-2023
OI Orgill, Dennis/0000-0002-8279-7310; 
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NR 27
TC 31
Z9 35
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD NOV 23
PY 2007
VL 8
AR 430
DI 10.1186/1471-2164-8-430
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 274AE
UT WOS:000253972900001
PM 18034909
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Makler, V
   Litt, JS
   Litofsky, NS
AF Makler, Vyacheslav
   Litt, Jeffrey S.
   Litofsky, N. Scott
TI Palliative Coverage of Cranial Defect following Failed Cranial Flap for
   Advanced Squamous Cell Carcinoma: Case Report
SO JOURNAL OF PALLIATIVE MEDICINE
LA English
DT Editorial Material
DE dermal regeneration template; head and neck cancer; head and neck
   wounds; negative pressure dressing; SCC; squamous cell carcinoma of the
   head and neck; vacuum-assisted closures
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE; NECK-CANCER; RECONSTRUCTION;
   SCALP; WOUNDS; BURN; HEAD; SKIN
AB Introduction: With advanced-stage head and neck cancers, patients may develop large and/or complex wounds despite multiple reconstruction attempts. Wound coverage may require novel approaches to palliate the patient.
   Method: We present the case of a 56-year-old female with advanced squamous cell carcinoma of the scalp and skull who required multiple surgical interventions. Despite our best reconstructive efforts, the patient subsequently developed scalp infection and sepsis, necessitating further debridement for source control. She then required coverage of the exposed dura and skull to prevent further infection.
   Results: The calvarial wound was covered with a dermal regeneration template and held in place by a vacuum-assisted closure (VAC) device. This coverage prevented additional infection and morbidity, was relatively easy and comfortable to manage, and demonstrated healing and development of granulation. Unfortunately, the patient succumbed to her systemic cancer before application of a palliative split-thickness skin graft.
   Conclusion: A VAC device and dermal regeneration template constituted an excellent modality for managing the complex calvarial wound encountered by otolaryngology, neurosurgery, and burn/wound services. The technique provided appropriate palliation for a patient with advanced head and neck cancer.
C1 [Makler, Vyacheslav] Dartmouth Hitchcock Med Ctr, Div Neurol Surg, Lebanon, NH 03766 USA.
   [Litt, Jeffrey S.] Univ Missouri, Sch Med, Div Acute Care Surg, Columbia, MO USA.
   [Litofsky, N. Scott] Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr,MC 321, Columbia, MO 65212 USA.
C3 Dartmouth College; University of Missouri System; University of Missouri
   Columbia; University of Missouri System; University of Missouri Columbia
RP Litofsky, NS (通讯作者)，Univ Missouri, Sch Med, Div Neurol Surg, One Hosp Dr,MC 321, Columbia, MO 65212 USA.
EM litofskyn@health.missouri.edu
RI Litofsky, N./AEU-0703-2022
FU Division of Neurological Surgery, University of Missouri-Columbia School
   of Medicine
FX This work was supported by research funds from Division of Neurological
   Surgery, University of Missouri-Columbia School of Medicine.
CR Akita S, 2016, INT J LOW EXTR WOUND, V15, P338, DOI 10.1177/1534734616670988
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   Kakarala K, 2011, ARCH OTOLARYNGOL, V137, P622, DOI 10.1001/archoto.2011.74
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   Powers AK, 2013, J NEUROSURG, V118, P302, DOI 10.3171/2012.10.JNS112241
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   Yeong EK, 2006, BURNS, V32, P375, DOI 10.1016/j.burns.2005.08.015
   Zhang YG, 2013, BMC MUSCULOSKEL DIS, V14, DOI 10.1186/1471-2474-14-76
NR 19
TC 10
Z9 11
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-6218
EI 1557-7740
J9 J PALLIAT MED
JI J. Palliat. Med.
PD JAN
PY 2018
VL 21
IS 1
BP 109
EP 113
DI 10.1089/jpm.2017.0258
PG 5
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA FS3GL
UT WOS:000419668600023
PM 28937303
DA 2026-07-24
ER

PT J
AU Yumun, G
   Erdolu, B
   Toktas, F
   Eris, C
   Ay, D
   Turk, T
   As, AK
AF Yumun, Gunduz
   Erdolu, Burak
   Toktas, Faruk
   Eris, Cuneyt
   Ay, Derih
   Turk, Tamer
   As, Ahmet Kagan
TI Deep Sternal Wound Infection after Coronary Artery Bypass Surgery:
   Management and Risk Factor Analysis for Mortality
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; OPEN PACKING; MEDIASTINITIS;
   THERAPY; STERNOTOMY
AB Background: Deep sternal wound infection is a life-threatening complication after cardiac surgery. The aim of this study was to investigate the factors leading to mortality, and to explore wound management techniques on deep sternal wound infection after coronary artery bypass surgery.
   Methods: Between 2008 and 2013, 58 patients with deep sternal wound infection were analyzed. Risk factors for mortality and morbidity including age, gender, body mass index, smoking status, chronic renal failure, hypertension, diabetes, and treatment choice were investigated.
   Results: In this study, 19 patients (32.7%) were treated by primary surgical closure (PSC), and 39 patients (67.3%) were treated by delayed surgical closure following a vacuum-assisted closure system (VAC). Preoperative patient characteristics were similar between the groups. Fourteen patients (24.1%) died in the postoperative first month. The mortality rate and mean duration of hospitalization in the PSC group was higher than in the VAC group (P = .026, P = .034). Significant risk factors for mortality were additional operation, diabetes mellitus, and a high level of EuroSCORE.
   Conclusions: Delayed surgical closure following VAC therapy may be associated with shorter hospitalization and lower mortality in patients with deep sternal wound infection. Additional operation, diabetes mellitus, and a high level of EuroSCORE were associated with mortality.
C1 [Yumun, Gunduz] Namik Kemal Univ, Sch Med, Dept Cardiovasc Surg, Tekirdag, Turkey.
   [Erdolu, Burak; Toktas, Faruk; Eris, Cuneyt; Ay, Derih; Turk, Tamer; As, Ahmet Kagan] Bursa Yuksek Ihtisas Educ & Res Hosp, Dept Cardiovasc Surg, Bursa, Turkey.
C3 Namik Kemal University; Yuksek Ihtisas Training & Research Hospital
RP Yumun, G (通讯作者)，Namik Kemal Univ, Sch Med, Dept Cardiovasc Surg, Tekirdag, Turkey.
EM gunduzyumun@gmail.com
RI Erdolu, Burak/JYO-5975-2024; Toktaş, Faruk/AAH-3495-2019; Yümün,
   Gündüz/M-1768-2015; AS, Ahmet Kagan/ABG-9688-2021
OI Toktaş, Faruk/0000-0002-0820-3879; Yümün, Gündüz/0000-0002-1503-329X;
   AS, Ahmet Kagan/0000-0001-8098-4393; TÜRK, TAMER/0000-0003-1668-020X
CR Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
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NR 15
TC 13
Z9 16
U1 0
U2 5
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD AUG
PY 2014
VL 17
IS 4
BP E212
EP E216
DI 10.1532/HSF98.2014346
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AZ0CH
UT WOS:000347913500008
PM 25179975
OA gold
DA 2026-07-24
ER

PT J
AU Khashkhusha, A
   Butt, S
   Abdelghaffar, M
   Wang, WL
   Rajananthanan, A
   Roy, S
   Khurshid, BN
   Zeinah, M
   Harky, A
AF Khashkhusha, Arwa
   Butt, Sundas
   Abdelghaffar, Mariam
   Wang, William
   Rajananthanan, Asveny
   Roy, Sakshi
   Khurshid, Bakht Noor
   Zeinah, Mohamed
   Harky, Amer
TI Sternal Wound Reconstruction Following Deep Sternal Wound Infection:
   Past, Present and Future: A Literature Review
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE deep sternal wound reconstruction; wound infection; multidisciplinary
   team; infection; flaps; surgical intervention; reconstruction; plastic
   surgery
ID VACUUM-ASSISTED CLOSURE; MYOCUTANEOUS ADVANCEMENT FLAPS; PECTORALIS
   MAJOR MUSCLE; STERNOTOMY WOUNDS; REDON CATHETERS; OMENTAL FLAP;
   RISK-FACTORS; ROUTINE USE; MANAGEMENT; COMPLICATIONS
AB This literature review critically examines the historical, current, and prospective dimensions of sternal wound reconstruction in the specific context of deep sternal wound infection (DSWI), aiming to enhance patient outcomes and optimise surgical techniques. Preventive measures, including prophylactic antibiotic administration and surgical site preparation, are crucial in reducing the incidence of DSWI. Effective management necessitates a multidisciplinary approach encompassing surgical debridement, drainage, and sternum repair utilising diverse procedures in conjunction with antibiotic therapy. Traditional approaches to managing DSWI involved closed irrigation and drainage techniques. While these methods exhibited certain advantages, they also exhibited limitations and varying degrees of success. The current care paradigms emphasise prophylactic antibiotic administration and surgical interventions like closed suction and irrigation, vacuum-assisted closure, and flap reconstruction. Future advancements in surgical techniques and technology hold promise for further enhancing sternal wound reconstruction. This review separates and emphasises the distinct roles of prophylaxis, antibiotic treatment, and reconstructive techniques, each relevant specifically to DSWI management. Collaborative efforts between cardiac and plastic surgeons, supported by ongoing research and innovation, are indispensable to advance sternal wound restoration and achieve superior outcomes in terms of patient welfare, morbidity and mortality reduction, and surgical efficacy.
C1 [Khashkhusha, Arwa] Univ Liverpool, Fac Hlth & Life Sci, Sch Med, Liverpool L3 5TR, England.
   [Butt, Sundas] Nottingham City Hosp, Dept Plast Surg, Nottingham NG5 1PB, England.
   [Abdelghaffar, Mariam] Royal Coll Surg Ireland, Sch Med, Bldg 2441,Rd 2835,Busaiteen 228,POB 15503, Muharraq, Bahrain.
   [Wang, William] Queen Mary Univ London, Barts & London Sch Med & Dent, London E1 2AD, England.
   [Rajananthanan, Asveny] Northampton Gen Hosp, Northampton NN1 5BD, England.
   [Roy, Sakshi] Queens Univ Belfast, Sch Pharm, Belfast BT9 7BL, North Ireland.
   [Khurshid, Bakht Noor] Univ Med & Dent Coll UMDC, Dept Med, Sargodha Rd,Univ Town, Faisalabad 38000, Punjab, Pakistan.
   [Zeinah, Mohamed] Ain Shams Univ, Fac Med, Cairo 11566, Egypt.
   [Harky, Amer] Liverpool Heart & Chest Hosp, Dept Cardiothorac Surg, Liverpool L14 3PE, England.
C3 University of Liverpool; Nottingham University Hospital NHS Trust;
   Nottingham City Hospital; Royal College of Surgeons in Ireland - RCSI;
   Royal College of Surgeons in Ireland - Medical University of Bahrain;
   University of London; Queen Mary University London; Queens University
   Belfast; Egyptian Knowledge Bank (EKB); Ain Shams University; Liverpool
   Heart & Chest Hospital
RP Harky, A (通讯作者)，Liverpool Heart & Chest Hosp, Dept Cardiothorac Surg, Liverpool L14 3PE, England.
EM asveny.rajananthanan2@nhs.net; amer.harky@lhch.nhs.uk
RI ; Butt, Sundas/LTZ-9164-2024; Harky, Amer/AAO-2125-2020
OI Roy, Sakshi/0000-0002-3519-9318; Butt, Sundas/0000-0003-0519-0715;
   khashkhusha, arwa/0000-0002-7407-8404; 
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NR 74
TC 6
Z9 8
U1 2
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD NOV
PY 2024
VL 11
IS 11
AR 361
DI 10.3390/jcdd11110361
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA N6G3N
UT WOS:001365297000001
PM 39590204
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mehkri, Y
   Sharaf, R
   Tishad, A
   Gendreau, J
   Hernandez, J
   Panther, E
   Pafford, R
   Rahmathulla, G
AF Mehkri, Yusuf
   Sharaf, Ramy
   Tishad, Abtahi
   Gendreau, Julian
   Hernandez, Jairo
   Panther, Eric
   Pafford, Ryan
   Rahmathulla, Gazanfar
TI Cost Savings Associated with Vacuum-Assisted Closure in Trauma Patients
   Undergoing Posterior Spinal Fusion
SO WORLD NEUROSURGERY
LA English
DT Article
DE Cost analysis; Minimally invasive; Negative pressure; Open; Posterior
   spinal fusion; Trauma; Wound vacuum
ID SURGICAL SITE INFECTION; CARE-ASSOCIATED INFECTIONS; PRESSURE WOUND
   THERAPY; IMPACT; PREVENTION; GUIDELINE; MORTALITY; OUTCOMES; RISK
AB -OBJECTIVE: To investigate the implications of vacuum -assisted closure (VAC) versus standard wound dressings on postoperative posterior spinal fusion (PSF) wounds with respect to potential cost savings associated with reduced incidence of surgical site infections. -METHODS: This was a retrospective review of trauma patients who underwent open PSF under the care of a single surgeon at a Level I trauma center. Patients were postoperatively monitored for 90 days. Statistical analysis was performed with c2 testing with the calculation of -umber needed to treat values.-RESULTS: Inclusion criteria were met by 208 patients who underwent open PSF. The c2 test revealed a significant increase in incidence of surgical site infections (20% vs. 8%; P = 0.021) in the non-VAC group (n = 112) compared with the VAC group (n = 96). Cost-benefit analysis revealed that use of VAC in patients undergoing open PSF could enable a mean cost savings of $163,492 per 100 patients. -CONCLUSIONS: Use of VAC in patients undergoing open PSF was associated with a 2-fold decrease in incidence of surgical site infections and an infection-related cost sav-ings of $163,492 per 100 patients. Further investigation is needed to ascertain additional benefits of VAC usage in patients undergoing open PSF.
C1 [Mehkri, Yusuf; Sharaf, Ramy; Tishad, Abtahi; Hernandez, Jairo; Panther, Eric; Pafford, Ryan; Rahmathulla, Gazanfar] Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32611 USA.
   [Gendreau, Julian] Johns Hopkins Whiting Sch Engn, Dept Biomed Engn, Baltimore, MD USA.
   [Rahmathulla, Gazanfar] Mayo Clin Hlth Syst, Dept Neurosurg, Eau Claire, WI 55905 USA.
C3 State University System of Florida; University of Florida; Johns Hopkins
   University
RP Rahmathulla, G (通讯作者)，Univ Florida, Dept Neurosurg, Coll Med, Jacksonville, FL 32611 USA.; Rahmathulla, G (通讯作者)，Mayo Clin Hlth Syst, Dept Neurosurg, Eau Claire, WI 55905 USA.
EM rahmathulla.gazanfar@mayo.edu
RI ; Rahmathulla FACS FCNS MBA, Gazanfar/D-1890-2014; Rahmathulla,
   Gazanfar/D-1890-2014
OI Sharaf, Ramy/0000-0001-9942-3852; Geneau, Julian/0000-0001-8412-0437;
   Rahmathulla FACS FCNS MBA, Gazanfar/0000-0002-0904-1840; 
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NR 30
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD MAR
PY 2023
VL 171
BP E147
EP E152
DI 10.1016/j.wneu.2022.11.103
EA FEB 2023
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA A0YC7
UT WOS:000952464800001
PM 36442776
DA 2026-07-24
ER

PT J
AU Brangewitz, M
   Voigtländer, T
   Helfritz, FA
   Lankisch, TO
   Winkler, M
   Klempnauer, J
   Manns, MP
   Schneider, AS
   Wedemeyer, J
AF Brangewitz, M.
   Voigtlaender, T.
   Helfritz, F. A.
   Lankisch, T. O.
   Winkler, M.
   Klempnauer, J.
   Manns, M. P.
   Schneider, A. S.
   Wedemeyer, J.
TI Endoscopic closure of esophageal intrathoracic leaks: stent versus
   endoscopic vacuum-assisted closure, a retrospective analysis
SO ENDOSCOPY
LA English
DT Article
ID THORACIC ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; GASTRIC-CARCINOMA;
   PLASTIC STENTS; PERFORATIONS; MANAGEMENT
AB Background and study aim: Placement of covered self-expanding metal or plastic stents (SEMS or SEPS) is an established method for managing intrathoracic leaks. Recently, endoscopic vacuum-assisted closure (EVAC) has been described as a new effective treatment option. Our aim was to compare stent placement with EVAC for nonsurgical closure of intrathoracic anastomotic leaks.
   Patients and methods: In a retrospective analysis we were able to identify 39 patients who were treated with SEMS or SEPS and 32 patients who were treated with EVAC for intrathoracic leakage. In addition to successful fistula closure, we analyzed hospital mortality, number of endoscopic interventions, incidence of stenoses, and duration of hospitalization.
   Results: In a multivariate analysis, successful wound closure was independently associated with EVAC therapy (hazard ratio 2.997, 95% confidence interval [95%CI] 1.568 - 5.729; P = 0.001). The overall closure rate was significantly higher in the EVAC group (84.4%) compared with the SEMS/SEPS group (53.8%). No difference was found for hospitalization and hospital mortality. We found significantly more strictures in the stent group (28.2% vs. 9.4% with EVAC, P < 0,05).
   Conclusions: EVAC is an effective endoscopic treatment option for intrathoracic leaks and showed higher effectiveness than stent placement in our cohort.
C1 [Brangewitz, M.; Voigtlaender, T.; Lankisch, T. O.; Manns, M. P.; Schneider, A. S.; Wedemeyer, J.] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany.
   [Helfritz, F. A.; Winkler, M.; Klempnauer, J.] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, Hannover, Germany.
   [Wedemeyer, J.] Robert Koch Hosp, Dept Internal Med, Gehrden, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Wedemeyer, J (通讯作者)，Gehrden Klinikum Reg Hannover, Dept Internal Med, Robert Koch Hosp, Von Reden Str 1, D-30989 Gehrden, Germany.
EM jochen.wedemeyer@krh.eu
RI Manns, Michael/AFG-3063-2022
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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NR 22
TC 190
Z9 229
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
EI 1438-8812
J9 ENDOSCOPY
JI Endoscopy
PD JUN
PY 2013
VL 45
IS 6
BP 433
EP 438
DI 10.1055/s-0032-1326435
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 157RH
UT WOS:000319916300007
PM 23733727
DA 2026-07-24
ER

PT J
AU Horch, RE
   Dragu, A
   Lang, W
   Banwell, P
   Leffler, M
   Grimm, A
   Bach, AD
   Uder, M
   Kneser, U
AF Horch, Raymund E.
   Dragu, Adrian
   Lang, Werner
   Banwell, Paul
   Leffler, Mareike
   Grimm, Andreas
   Bach, Alexander D.
   Uder, Michael
   Kneser, Ulrich
TI Coverage of exposed bones and joints in critically ill patients: Lower
   extremity salvage with topical negative pressure therapy
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TIBIAL SHAFT FRACTURES; POINT-OF-VIEW;
   SUBATMOSPHERIC PRESSURE; RECONSTRUCTIVE SURGERY; TEMPORARY TREATMENT;
   INJURIES; FLAP; WOUNDS; DEFECT
AB Background: Soft tissue defects of the limb with exposure of tendons and bones in critically ill patients usually lead to extremity amputation. A potential treatment with topical negative pressure may allow split-thickness skin grafting to the bone, which leads to limb salvage.
   Materials and Methods: We report on 21 multimorbid patients, 46 to 80 years of age, with severe lower limb soft tissue loss and infection with exposed bone following debridement with critical limb ischemia. Attempts to salvage the extremities were undertaken with repeated surgical debridement followed by vacuum-assisted closure therapy and subsequent split-thickness skin grafting procedures.
   Results: Infection control and limb salvage were achieved in all cases with multiple debridements, topical negative pressure therapy, and skin grafts. In all patients, the exposure of tendons and bones was reversible by this strategy without a free flap transfer.
   Discussion: The patients described in this study were severely compromised by systemic and vascular disorders, so extremity amputation had been considered owing to the overall condition and the exposure of tendons and bones. Since it was possible to salvage the affected limbs with this straightforward and simple procedure, this type of treatment should be considered as a last attempt to prevent amputation.
C1 [Horch, Raymund E.] Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Dept Gen Visceral & Thorac Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Inst Radiol, D-91054 Erlangen, Germany.
   Nuffield Hosp Brighton, Dept Plast & Reconstruct Surg, E Grinstead, W Sussex, England.
   Queen Victoria Hosp, E Grinstead, W Sussex, England.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Dept Gen Visceral & Thorac Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horck@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019; Dragu, Adrian/AAH-3506-2019
OI Horch, Raymund E/0000-0002-6561-2353; Dragu, Adrian/0000-0003-4633-2695
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NR 46
TC 18
Z9 22
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD SEP-OCT
PY 2008
VL 12
IS 5
BP 223
EP 229
DI 10.2310/7750.2008.07073
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 357NW
UT WOS:000259854400004
PM 18845091
DA 2026-07-24
ER

PT J
AU Derrick, KL
   Norbury, K
   Kieswetter, K
   Skaf, J
   McNulty, AK
AF Derrick, Kathleen L.
   Norbury, Kenneth
   Kieswetter, Kris
   Skaf, Jihad
   McNulty, Amy K.
TI Comparative analysis of global gene expression profiles between diabetic
   rat wounds treated with vacuum-assisted closure therapy, moist wound
   healing or gauze under suction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Diabetic; Gene expression; Microarray; VAC; Wound healing
ID FOOT; REPAIR; AMPUTATION; RESPONSES
AB How differential gene expression affects wound healing is not well understood. In this study, Zucker diabetic fatty (fa/fa) male inbred rats were used to investigate gene expression during wound healing in an impaired wound-healing model. Whole genome microarray surveys were used to gain insight into the biological pathways and healing processes in acute excisional wounds treated with vacuum-assisted closure (V.A.C.(R)) Therapy, moist wound healing (MWH) or gauze under suction (GUS). Global gene expression analyses after 2 days of healing indicated major differences with respect to both number of genes showing fold changes and pathway regulation between the three different wound treatments. Statistical analysis of expression profiles indicated that 5072 genes showed a >1.6-fold change with V. A. C. Therapy compared with 3601 genes with MWH and 3952 genes with GUS. Pathways and related genes associated with the early phases of wound healing diverged between treatment groups. For example, pathways involving angiogenesis, cytoskeletal regulation and inflammation were associated with elevated gene expression following V. A. C. Therapy. This study is the first to assess wound healing by whole genome interrogation in a diabetic rat model treated with different healing modalities.
C1 [Derrick, Kathleen L.; Norbury, Kenneth; Kieswetter, Kris; McNulty, Amy K.] Kinet Concepts Inc, San Antonio, TX USA.
   [Skaf, Jihad] Appl Biosyst Inc, Foster City, CA 94404 USA.
C3 Thermo Fisher Scientific; Applied Biosystems
RP Derrick, KL (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX USA.
EM kathleen.derrick@kci1.com
FU Kinetic Concepts Inc (KCI)
FX We thank Barbara Collins, Crissy Jenschke, Lisa Hartson and Leslie
   Sanchez for animal work and providing tissue samples. Financial support
   - Kinetic Concepts, Inc; KLD, KN, KK and AKM are used at Kinetic
   Concepts Inc (KCI). JS is employed at Applied Biosystems Inc.
CR ANDROS G, 2006, OSTOMY WOUND MANAG, V18, pS1
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NR 44
TC 24
Z9 35
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2008
VL 5
IS 5
BP 615
EP 624
DI 10.1111/j.1742-481X.2008.00544.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BF
UT WOS:000207844400005
PM 19134062
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Wackenfors, A
   Sjögren, J
   Gustafsson, R
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
AF Wackenfors, A
   Sjögren, J
   Gustafsson, R
   Algotsson, L
   Ingemansson, R
   Malmsjö, M
TI Effects of vacuum-assisted closure therapy on inguinal wound edge
   microvascular blood flow
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PRESSURE; TISSUE; EXPERIENCE
AB Vacuum-assisted closure (VAC) therapy has been shown to facilitate wound healing. Data on the mechanisms are scarce, although beneficial effects on blood flow and granulation tissue formation have been presented. In the current study, laser Doppler was used to measure microvascular blood flow to an inguinal wound in pigs during VAC therapy (- 50 to - 200 mmHg), including consideration of the different tissue types and the distance from the wound edge. VAC treatment induced an increase in microvascular blood flow a few centimeters from the wound edge. The increase in blood flow occurred closer to the wound edge in muscular as compared to subcutaneous tissue (1.5 cm and 3 cm, at - 75 mmHg). In the immediate proximity to the wound edge, blood flow was decreased. This hypoperfused zone was increased with decreasing pressure and was especially prominent in subcutaneous as compared to muscular tissue (0-1.9 cm vs. 0-1.0 cm, at - 100 mmHg). When VAC therapy was terminated, blood flow increased multifold, which may be due to reactive hyperemia. In conclusion, VAC therapy affects microvascular blood flow to the wound edge and may thereby promote wound healing. A low negative pressure during treatment may be beneficial, especially in soft tissue, to minimize possible ischemic effects. Intermittent VAC therapy may further increase blood flow.
C1 Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Wackenfors, A (通讯作者)，Expt Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM angelica.wackenfors@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599
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NR 22
TC 227
Z9 314
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2004
VL 12
IS 6
BP 600
EP 606
DI 10.1111/j.1067-1927.2004.12602.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 870AU
UT WOS:000225027200002
PM 15555050
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Gonzalez, MR
   de Groot, TM
   Werenski, JO
   Fourman, MS
   Morse, AS
   Lozano-Calderon, SA
AF Gonzalez, Marcos R.
   de Groot, Tom M.
   Werenski, Joseph O.
   Fourman, Mitchell S.
   Morse, Ashlyn S.
   Lozano-Calderon, Santiago A.
TI Wound vacuum-assisted closure temporization after tumor resection of
   soft tissue sarcomas-A cost analysis in a propensity-score matched
   population
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE local recurrence; cost analysis; myxofibrosarcoma; soft tissue sarcoma;
   vacuum-assisted closure
ID RECURRENCE
AB BackgroundVacuum-assisted closure (VAC) temporization is a technique associated with high local control rates used in myxofibrosarcoma. We sought to compare the costs and postoperative outcomes of VAC temporization and single-stage (SS) excision/reconstruction.MethodsWe conducted a retrospective analysis of patients with myxofibrosarcoma surgically treated at our institution between 2000 and 2022. Variables of interest included total, direct, and indirect costs for initial episode of care, 90 days and 1 year after initial admission, and postoperative outcomes. Costs were compared between the VAC temporization and SS groups.ResultsAfter matching, 13 patients in the SS group and 23 in the VAC group were analyzed. We found no difference in median and mean total inpatient costs, between the VAC temporization and SS group. While total 90-day and 1-year costs were higher in the VAC group compared to the SS group, mean costs were similar. There were no differences in postoperative complications between groups. A subanalysis of the entire cohort (n = 139) revealed lower local recurrence and overall death rates in the VAC temporization group.ConclusionVAC temporization had similar inpatient costs and postoperative outcomes to SS excision/reconstruction. While median 90-day and 1-year costs were higher in the VAC group, mean costs did not differ.
C1 [Gonzalez, Marcos R.; de Groot, Tom M.; Werenski, Joseph O.; Morse, Ashlyn S.; Lozano-Calderon, Santiago A.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA USA.
   [Fourman, Mitchell S.] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Orthopaed Surg, New York, NY USA.
   [Lozano-Calderon, Santiago A.] Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA 02144 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School; Yeshiva University; Montefiore
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Lozano-Calderon, SA (通讯作者)，Massachusetts Gen Hosp, Dept Orthopaed Surg, Div Orthopaed Oncol, Boston, MA 02144 USA.
EM slozanocalderon@mgh.harvard.edu
RI Fourman, Mitchell/GXF-4477-2022; Gonzalez, Marcos Roberto/IAP-3703-2023
OI Gonzalez, Marcos Roberto/0000-0002-3352-6362; Werenski,
   Joseph/0009-0003-9177-6874
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Werenski JO, 2024, ANN SURG ONCOL, V31, P2786, DOI 10.1245/s10434-024-14932-7
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   Wu CC, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000431
NR 22
TC 6
Z9 6
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD AUG
PY 2024
VL 130
IS 2
BP 301
EP 309
DI 10.1002/jso.27698
EA MAY 2024
PG 9
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA A4I1E
UT WOS:001231031100001
PM 38798273
DA 2026-07-24
ER

PT J
AU Anagnostakos, K
   Kelm, J
   Schmitt, E
AF Anagnostakos, K
   Kelm, J
   Schmitt, E
TI Indications for use of the VAC®-system in the orthopedic surgery
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE infection; VAC (R)-therapy; hardware preservation
ID VACUUM-ASSISTED CLOSURE; FLAP; THERAPY; MUSCLE; WOUNDS; ACHILLES;
   DEVICE; RECONSTRUCTION; OSTEOMYELITIS; ARTHROPLASTY
AB Introduction: The vacuum-assisted closure (V.A.C.(R))-therapy is accepted for an efficient option in the treatment of infected wounds with healing complications. However, reports on its use in the septic orthopedic surgery are seldom. Hence, the aim of this study is to demonstrate our experience with the V.A.C.(R)-system in the treatment of orthopedic-related infections. Patients-Methods: Various musculoskeletal infections with prolonged wound healing (infections after Achilles tendon reconstruction, fibula osteosynthesis, dorsal spondylodesis, and total hip arthroplasty, skin necrosis after total knee arthroplasty and wound dehiscence after resection and irradiation of a liposarcoma) have been treated with the V.A.C.(R)-device. After infection sanitation we performed skin graft transplantation in 3 cases for definitive wound closure, also assisted by the V.A.C.(R)-therapy. Results: An infection eradication with implant preservation, where necessary, could have been achieved in all cases. No complications were observed in the cases with the skin graft transplantations. No infection persistence or reinfection occurred at a mean follow-up of 36 months. Discussion: The V.A.C.(R)-therapy seems to be a valuable adjunct in the treatment of infected wounds in the orthopedic surgery, however, definitive conclusion should await the results of future clinical studies with large series.
C1 Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM konstantinos.anagnostakos@uniklinik-saarland.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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NR 30
TC 4
Z9 5
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S87
EP S92
DI 10.1055/s-2006-921514
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100020
PM 16575653
DA 2026-07-24
ER

PT J
AU Yanar, H
   Sivrikoz, E
AF Yanar, Hakan
   Sivrikoz, Emre
TI Management of Open Abdomen: Single Center Experience
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE-CONTROL LAPAROTOMY; FASCIAL
   CLOSURE; VENTRAL HERNIA
AB Aim. The authors reviewed their experience in the management of open abdomen using the vacuum-assisted closure (VAC), in order to assess its morbidity, and the outcome of abdominal wall integrity. Methods. A retrospective review was performed using the trauma registry to identify patients undergoing temporary abdominal closure (TAC) either using Bogota Bag (BB) or VAC, from January 2006 to December 2012. Inclusion criteria were TAC and survival to definitive abdominal closure. Data collected included age, indication for TAC, number of operating room procedures, primary fascial closure rate, and complications. Results. During the study period, 156 patients required one type of TAC. Mean number of operations required in BB group was 3.04 as compared to 1.96 in VAC group (P = 0.006). Survival was significantly increased in the VAC group (P < 0.001). The difference in primary closure rates did not reach statistical significance (25% vs. 55%; P = 0.074). Complications were observed less frequently in the VAC group (P = 0.047). The mean time for fascial closure was 21 (+/- 12) days in the BB group, as opposed to 6 (+/- 3) days in the VAC group (P < 0.001). Conclusion. The vacuum assisted closure (VAC) has a significantly faster rate of closure, requires less number of operations, and is associated with a lower complication rate.
C1 [Yanar, Hakan; Sivrikoz, Emre] Istanbul Univ, Istanbul Sch Med, Dept Gen Surg, TR-34390 Istanbul, Turkey.
C3 Istanbul University
RP Yanar, H (通讯作者)，Istanbul Univ, Istanbul Sch Med, Dept Gen Surg, Millet Cad, TR-34390 Istanbul, Turkey.
EM htyanar@yahoo.com
RI Sivrikoz, Emre/F-1844-2016; Yanar, Hakan/AAY-9163-2020
OI Sivrikoz, Emre/0000-0001-9905-0224; Yanar, Hakan/0000-0002-6162-0989
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NR 11
TC 2
Z9 3
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2013
VL 2013
AR 584378
DI 10.1155/2013/584378
PG 3
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 260XV
UT WOS:000327628800001
PM 24348537
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Huang, YX
   Yu, ZY
   Xu, MR
   Zhao, XT
   Tang, YZ
   Luo, L
   Deng, DT
   Chen, MW
AF Huang, Yixuan
   Yu, Zhenyi
   Xu, Murong
   Zhao, Xiaotong
   Tang, Yizhong
   Luo, Li
   Deng, Datong
   Chen, Mingwei
TI Negative pressure wound therapy promotes wound healing by
   down-regulating miR-155 expression in granulation tissue of diabetic
   foot ulcers
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Diabetic foot ulcer (DFU); Negative pressure wound therapy (NPWT);
   Normal human dermal fibroblasts (NHDFs); MicroRNA; miR-155
AB Our study aims to investigate the effect of negative pressure wound therapy (NPWT) on microRNA-155 (miR-155) in the granulation tissue of patients suffering from diabetic foot ulcers (DFUs) and its correlation with wound healing. A total of sixty patients diagnosed with DFUs were randomly assigned to either the NPWT group (n = 40) or the Non-NPWT group (n = 20) in a 2:1 ratio. After debridement, the NPWT group received NPWT treatment for one week, while the Non-NPWT group underwent routine dressing therapy. The expression of miR-155 in DFU granulation tissues was evaluated by qRT-PCR before and after treatment for one week. Following termination, wound healing rates were assessed in the NPWT group, and the correlation between variations in miR-155 expression (Delta miR-155) and wound healing was analyzed pre and post NPWT treatment. In vitro experiments were conducted to investigate the effects of negative pressure on variations of miR-155 expression, as well as proliferation, migration, and apoptosis in normal human dermal fibroblasts (NHDFs). The NPWT group showed a decrease in miR-155 expression in wound granulation tissue compared with pre-treatment [4.12 (1.22, 14.85) vs. 6.83 (2.15, 15.72), P < 0.05]. Conversely, there was no statistically significant difference in miR-155 expression in wound granulation tissue between pre-treatment and post-treatment in the Non-NPWT group (P > 0.05). However, analysis revealed a positive correlation between Delta miR-155 and wound healing rate after 4 weeks in the NPWT group (chi 2 = 4.829, P = 0.028). The in vitro experiments showed a significant decrease in miR-155 expression in NHDFs under negative pressure measured at -125 mmHg (P < 0.05). This reduction in miR-155 expression, in turn, enhanced the proliferation and migration ability while decreasing the apoptosis rate of NHDFs by targeting the upregulation of fibroblast growth factor 7 (FGF7) gene expression (P < 0.05). It is concluded that NPWT promotes DFU healing by reducing the expression of miR-155 in granulation tissue and the efficacy of NPWT correlated with altered miR-155 expression in wound tissue.
C1 [Huang, Yixuan; Yu, Zhenyi; Xu, Murong; Zhao, Xiaotong; Luo, Li; Deng, Datong; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
   [Tang, Yizhong] Anhui Med Univ, Affiliated Hosp 1, Dept Burn, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM chmw1@163.com
FU Natural Science Foundation of Anhui Province in China; Department of
   Endocrinology in the First Affiliated Hospital of Anhui Medical
   University
FX We are grateful to the all patients for participating in the study. We
   thank the participants of this study including the doctors, nurses, and
   researchers from the Department of Endocrinology in the First Affiliated
   Hospital of Anhui Medical University.
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   Shojania HR, 2019, INT J LOW EXTR WOUND, V18, P143, DOI 10.1177/1534734619842975
   van Solingen C, 2014, J CELL MOL MED, V18, P1104, DOI 10.1111/jcmm.12255
   Vigorito E, 2013, IMMUNOL REV, V253, P146, DOI 10.1111/imr.12057
   Wu TT, 2021, DIABET METAB SYND OB, V14, P4263, DOI 10.2147/DMSO.S326066
   Xu MR, 2022, DIABET METAB SYND OB, V15, P3415, DOI 10.2147/DMSO.S376292
   Yang LL, 2017, J MOL HISTOL, V48, P147, DOI 10.1007/s10735-017-9713-8
   Ye JN, 2017, INT J LOW EXTR WOUND, V16, P74, DOI 10.1177/1534734617706636
NR 29
TC 8
Z9 9
U1 2
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 25
PY 2025
VL 15
IS 1
AR 6733
DI 10.1038/s41598-025-90643-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Y5S0C
UT WOS:001432705000045
PM 40000694
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lee, SK
   An, YS
   Choy, WS
AF Lee, Sang Ki
   An, Young Sun
   Choy, Won Sik
TI Management of Hardware-Exposed Soft Tissue Defects Using Dermal
   Substitutes and Negative Pressure Wound Therapy
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE artificial dermis; negative-pressure wound therapy; hardware-exposed
   wounds; skin grafting
ID RECONSTRUCTION
AB IntroductionReconstruction of complex injuries of the extremities with full-thickness wounds is a challenging but important task. If primary closure is not feasible, more complex procedures are required, such as split-thickness skin graft or flap surgery. Recently, several studies have shown good results when combined with negative pressure wound therapy (NPWT) and artificial dermal replacement therapy after extensive surgical debridement and NPWT administration for severe complex wounds accompanied by tendon or bone exposure. However, flap surgery remains the only treatment for wounds in which the hardware is exposed after fracture fixation. Therefore, in this study, we attempted to prove the usefulness of the combined treatment using artificial dermal substitutes (MatriDerm) and NPWT by focusing on hardware-exposed wounds, which have not been studied before.MethodsFrom 2019 to 2021, we treated with our wound management procedure 14 patients with hardware-exposing wounds after internal fixation using plates, out of 48 patients with full-thickness posttraumatic skin defect. Before skin grafting, after surgical debridement and thorough washouts, MatriDerm was placed and NPWT was applied over it. This staged approach aimed at conditioning even the most complex wounds so that closure with MatriDerm-augmented skin grafting would become possible in a one-step approach.ResultsWe stratified the duration of treatment and number of replacements in NPWT according to the type of injury. Cases with open fractures required significantly longer NPWT than those with closed fractures (P = 0.01); however, there was no significant difference between the Gustilo-Anderson classification within open fractures (P > 0.05). Patients with open fractures underwent a mean of 6.6 changes while those with closed fractures underwent 2.5 (P = 0.002) until the final wound closure with MatriDerm-augmented skin grafting was performed. There was no significant difference in the treatment period based on the location and size of the wound, and there was no significant difference in the number of NPWT replacements. Skin grafting was successful in all 14 patients.ConclusionsThis study revealed that NPWT and artificial dermis-augmented skin grafting after combined treatment with NPWT and artificial dermis were sufficiently useful for hardware-exposed wounds, where flap surgery has been considered the only treatment to date.
C1 [Lee, Sang Ki; An, Young Sun; Choy, Won Sik] Eulji Univ, Coll Med, Dept Orthoped Surg, Daejeon, South Korea.
   [Lee, Sang Ki] Dept Orthoped Surg, 1306 Dunsan Dong, Daejeon 35233, South Korea.
C3 Eulji University
RP Lee, SK (通讯作者)，Dept Orthoped Surg, 1306 Dunsan Dong, Daejeon 35233, South Korea.
EM sklee@eulji.ac.kr; nervcobe@naver.com; orthoplsk@naver.com
CR Cervelli V, 2011, INT WOUND J, V8, P400, DOI 10.1111/j.1742-481X.2011.00806.x
   Choi JY, 2014, ARCH PLAST SURG-APS, V41, P337, DOI 10.5999/aps.2014.41.4.337
   Cristofari S, 2020, ANN CHIR PLAST ESTH, V65, P213, DOI 10.1016/j.anplas.2019.06.009
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   Kakagia DD, 2023, INT J LOW EXTR WOUND, V22, P56, DOI 10.1177/1534734621990311
   Kuran I, 2000, PLAST RECONSTR SURG, V105, P574, DOI 10.1097/00006534-200002000-00015
   Lempert M, 2022, LANGENBECK ARCH SURG, V407, P327, DOI 10.1007/s00423-021-02224-7
   Melandri D, 2020, INT J LOW EXTR WOUND, V19, P78, DOI 10.1177/1534734619884422
   MCh DKPM, 2018, International Journal Of Medical Science And Clinical Invention, V5, P3383, DOI [10.18535/ijmsci/v5i1.01, 10.18535/ijmsci/v5i1.01, DOI 10.18535/IJMSCI/V5I1.01]
   Nakamura Y, 2020, NAGOYA J MED SCI, V82, P291, DOI 10.18999/nagjms.82.2.291
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NR 19
TC 5
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2023
VL 90
IS 3
BP 242
EP 247
DI 10.1097/SAP.0000000000003440
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9D3BJ
UT WOS:000935975600010
PM 36796046
DA 2026-07-24
ER

PT J
AU Young, CNJ
   Ng, KYB
   Webb, V
   Vidow, S
   Parasuraman, R
   Umranikar, S
AF Young, Christopher N. J.
   Ng, Ka Ying Bonnie
   Webb, Vanessa
   Vidow, Sarah
   Parasuraman, Rajeswari
   Umranikar, Sameer
TI Negative pressure wound therapy aids recovery following surgical
   debridement due to severe bacterial cellulitis with abdominal abscess
   post-cesarean A case report (CARE-Compliant)
SO MEDICINE
LA English
DT Article
DE Cesarean; cellulitis; negative pressure wound therapy (NPWT);
   obstetrics; PICO; RENASYS GO
ID CESAREAN-SECTION
AB Introduction: Bacterial cellulitis post-Cesarean section is rare. Negative pressure wound therapy (NPWT) is widely used in various medical specialities; its effectiveness in obstetrics however remains the topic of debate-used predominantly as an adjunct to secondary intention specific to high-risk patient groups. Its application in the treatment of actively infected wounds post-Cesarean is not well documented. Here, we document NPWT in the treatment of an unusually severe case of bacterial cellulitis with abdominal abscess postpartum. We provide a unique photographic timeline of wound progression following major surgical debridement, documenting the effectiveness of 2 different NPWT systems (RENASYS GO and PICO, Smith & Nephew). We report problems encountered using these NPWT systems and "ad-hoc" solutions to improve efficacy and patient experience.
   A 34-year-old primiparous Caucasian female with no prior history or risk factors for infection and a normal body mass index (BMI) presented with severe abdominal pain, swelling, and extensive abdominal redness 7 days postemergency Cesarean section. Examination revealed extensive cellulitis with associated abdominal abscess. Staphylococcus aureus was identified in wound exudates and extensive surgical debridement undertaken day 11 postnatally due to continued febrile episodes and clinical deterioration, despite aggressive intravenous antibiotic therapy. Occlusive NPWT dressings were applied for a period of 3 weeks before discharge, as well as a further 5 weeks postdischarge into the community.
   NPWT was well tolerated and efficacious in infection clearance and wound healing during bacterial cellulitis. Wound healing averaged 1cm(2) per week before NPWT withdrawal; cessation of NPWT before full wound closure resulted in significantly reduced healing rate, increased purulent discharges, and skin irritation, highlighting the efficacy of NPWT. Five-month follow-up in the clinic found the wound to be fully healed with no additional scarring beyond the boundaries of the original Cesarean incision. The patient was pleased with treatment outcomes, reporting no lasting pain or discomfort from the scar. Conclusions: This report represents the first documented use of NPWT to aid healing of an actively infected, open wound following extensive surgical debridement 10 days post-Cesarean section, confirming both the efficacy and tolerability of NPWT for the treatment of severe bacterial cellulitis in obstetric debridement.
C1 [Young, Christopher N. J.] Univ Portsmouth, Sch Pharm & Biomed Sci, Dept Mol Med, Portsmouth, Hants, England.
   [Ng, Ka Ying Bonnie; Webb, Vanessa; Vidow, Sarah; Parasuraman, Rajeswari; Umranikar, Sameer] Princess Anne Hosp, Dept Obstet & Gynaecol, Southampton, Hants, England.
C3 University of Portsmouth
RP Young, CNJ (通讯作者)，Univ Portsmouth, Sch Pharm & Biomed Sci, Mol Med, St Michaels Bldg, Portsmouth PO1 2DT, Hants, England.
EM christopher.young@port.ac.uk
FU National Institute for Health Research [ACF-2015-26-010] Funding Source:
   researchfish
CR [Anonymous], 2015, COCHRANE DB SYST REV
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NR 17
TC 6
Z9 6
U1 2
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2016
VL 95
IS 50
AR e5397
DI 10.1097/MD.0000000000005397
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH2SN
UT WOS:000391618400009
PM 27977577
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Esen, E
   Morkavuk, SB
   Turan, M
   Akyuz, S
   Guler, S
   Akgul, GG
   Bahcecioglu, IB
   Gulcelik, MA
   Yilmaz, KB
AF Esen, Ebru
   Morkavuk, Sevket Baris
   Turan, Mujdat
   Akyuz, Simay
   Guler, Sumeyra
   Akgul, Gokhan Giray
   Bahcecioglu, Ibrahim Burak
   Gulcelik, Mehmet Ali
   Yilmaz, Kerim Bora
TI The use of incisional negative-pressure wound therapy on high-risk
   patients with breast cancer after mastectomy
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE Breast cancer; Seroma; Wound complications; Incisional negative pressure
   wound therapy; iNPWT
ID SURGICAL SITE INFECTIONS; MANAGEMENT-SYSTEM; SEROMA FORMATION; SURGERY;
   CLOSURE; COMPLICATIONS; MECHANISM; REVERSAL; IMPACT; DELAY
AB Background: The main complications seen in patients who have undergone modified radical mastectomy (MRM) are seroma, surgical site infection, hematoma, wound dehiscence, flap necrosis, and nerve damage. While these complications lead to some problems the most feared effect in the early period is that they cause a delay in adjuvant treatment. Incisional Negative Pressure Wound Therapy (iNPWT) decreases wound dehiscence by reducing oedema and tension, especially in the incision line. This study aim to compare recovery times and wound site complications between patients treated with conventional wound dressings and patients treated with iNPWT after MRM. Methods: A retrospective screening was made of the data of 50 patients who underwent MRM because of breast cancer in the General Surgery Clinic of XXX Hospital between 2018 and 2022, and were at highrisk of wound site complications. Two groups were formed as 30 patients applied with iNPWT and 20 patients applied with conventional dressings. Results: The mean age of the 50 female patients was 53.58 years (range, 30-80 years). The most frequently seen complications were seroma (20 patients) and partial flap ischaemia (14 patients). The mean number of iNPWT applications was 1.30 (range, 1-2), and the mean number of days of application was 4.47 (range, 2-9). Postoperative seroma was observed in 8 patients in the iNPWT group and in 12 patients in the conventional dressings group (p = 0.018). Flap ischaemia and the probability of dehiscence was determined at a statistically significantly higher rate in the patients in the conventional dressings groups (p = 0.005, p = 0.021). Conclusion: The results of this study demonstrated that the use of iNPWT significantly reduced the amount of postoperative drainage, thereby contributing to early drain removal. Furthermore, iNPWT significantly reduced postoperative seroma, flap ischaemia, and flap dehiscence compared to conventional dressings. (c) 2024 Asian Surgical Association and Taiwan Society of Coloproctology. Publishing services by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Esen, Ebru] Istinye Univ, Bahcesehir Liv Hosp, Dept Surg Oncol, Istanbul, Turkiye.
   [Morkavuk, Sevket Baris; Turan, Mujdat; Akyuz, Simay; Guler, Sumeyra; Akgul, Gokhan Giray; Bahcecioglu, Ibrahim Burak; Gulcelik, Mehmet Ali; Yilmaz, Kerim Bora] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Gen Dr Tevfik Saglam 1 Etlik, TR-06010 Ankara, Turkiye.
C3 Istinye University; University of Health Sciences Turkey; Gulhane
   Training & Research Hospital
RP Yilmaz, KB (通讯作者)，Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Gen Dr Tevfik Saglam 1 Etlik, TR-06010 Ankara, Turkiye.
EM borakerim@yahoo.com; kerimbora.yilmaz@sbu.edu.tr
RI gulcelik, mehmet ali/LKK-6450-2024; Akyüz, Simay/KXS-0711-2024; Yilmaz,
   Kerim Bora/HJI-8568-2023; MORKAVUK, Sevket Baris/ABB-3437-2021
OI gulcelik, mehmet ali/0000-0002-8967-7303; Akyüz,
   Simay/0000-0002-0464-8934; Bahçecioğlu, İbrahim
   burak/0000-0001-9417-3866; MORKAVUK, Sevket Baris/0000-0003-0441-0333
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NR 52
TC 3
Z9 5
U1 1
U2 7
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2025
VL 48
IS 1
BP 185
EP 192
DI 10.1016/j.asjsur.2024.07.333
EA DEC 2024
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S9M9B
UT WOS:001401385000001
PM 39164174
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Elhassan, H
   Amjad, R
   Palaniappan, U
   Loubani, M
   Rose, D
AF Elhassan, Hind
   Amjad, Ridha
   Palaniappan, Unna
   Loubani, Mahmoud
   Rose, David
TI The negative pressure wound therapy for prevention of sternal wound
   infection: Can we reduce infection rate after the use of bilateral
   internal thoracic arteries? A systematic literature review and
   meta-analysis
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; Bilateral internal mammary artery;
   Sternal wound infections; Coronary artery bypass grafting
ID INCISION MANAGEMENT; RISK-FACTORS; SURVIVAL; GRAFTS
AB Background Negative pressure wound therapy (NPWT) is traditionally used to treat postoperative wound infections. However, its use in closed wound sternotomy post cardiac surgery in high-risk patients has become increasingly popular. The potential preventive benefit of reducing sternal wound infections has been recently acknowledged. Bilateral internal mammary artery (BIMA) grafts are used in coronary artery bypass grafting but have been associated with an increased risk of sternal wound infections (SWIs). Objectives This systematic analysis examines whether NPWT can reduce the incidence of SWI following BIMA grafts, leading to more patients benefiting from the better survival outcome associated with BIMA grafting. MethodA comprehensive systematic search and meta-analysis were performed to identify studies on the use of NPWT in closed wound sternotomy. Ovid MEDLINE (in-process and other nonindexed citations and Ovid MEDLINE 1990 to present), Ovid EMBASE (1990 to present), and The Cochrane Library (Wiley), PubMed, and Google Scholar databases were searched from their inception to May 2022 using keywords and MeSH terms. Thirty-four articles from 1991 to May 2022 were selected. Result Three studies reported on the outcome of NPWT following BIMA grafting. The pooled analysis did not show any significant difference in the incidence of sternal wound infection between NPWT and standard dressing (RR 0.48 95% CI 0.17-1.37; P = 0.17) with substantial heterogeneity (I2 65%). Another seven studies were found comparing the outcome of SWI incidence of negative pressure closed wound therapy with conventional wound therapy in patients undergoing adult cardiac surgery. The pooled analysis showed that NPWT was associated with a low risk of SWIs compared to conventional dressing (RR 0.47 95% CI 0.36-0.59; P < 0.00001), with low heterogeneity (I2 1%). Conclusion The literature identified that NPWT significantly decreased the incidence of sternal wound complications when applied to sutured sternotomy incisions in high-risk patients, and in some cases, it eliminated the risk. However, the inadequate number of randomized controlled trials assessing the effectiveness of NPWT in BIMA grafting emphasizes the need for further, robust studies.
C1 [Elhassan, Hind; Loubani, Mahmoud] Hull Univ Teaching Hosp NHS Fdn Trust, Cardiothorac Dept, Castle Rd, Cottingham HU16 5JQ, East Riding Of, England.
   [Amjad, Ridha; Palaniappan, Unna] Univ Lancaster, Lancaster Med Sch, Lancaster, England.
   [Rose, David] Blackpool Teaching Hosp NHS Fdn Trust, Lancashire Cardiac Ctr, Cardiothorac Dept, Blackpool, England.
C3 Lancaster University
RP Elhassan, H (通讯作者)，Hull Univ Teaching Hosp NHS Fdn Trust, Cardiothorac Dept, Castle Rd, Cottingham HU16 5JQ, East Riding Of, England.
EM hind.elhassan@nhs.net
RI Rose, David/OSH-8476-2025
CR [Anonymous], New study demonstrates PICO Single Use Negative Pressure Wound Therapy System (sNPWT) beats standard dressings in reducing surgical site complications resulting in fewer deep sternal wound infections (DSWI) following cardiac surgery
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NR 39
TC 5
Z9 7
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD FEB 12
PY 2024
VL 19
IS 1
AR 87
DI 10.1186/s13019-024-02589-y
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HR3G6
UT WOS:001161188000001
PM 38342923
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hou, TJ
   Swee, TT
   Hiik, KLC
   Saad, AZM
   Malik, SA
AF Hou, Tan Jia
   Swee, Tan Tian
   Hiik, Kelvin Ling Chia
   Saad, Arman Zaharil Mat
   Malik, Sameen Ahmed
TI Two-N input output mapping relationship fuzziness adaptation approach
   for fuzzy based negative pressure wound Therapy system
SO EXPERT SYSTEMS WITH APPLICATIONS
LA English
DT Article
DE Negative pressure wound therapy; Limitation of fuzziness setting; Two
   relationship equation fuzziness adaptation; approach
AB Negative Pressure Wound Therapy (NPWT) is a vacuum assisted wound therapy technique. It has been widely applied for the chronic wound treatment due to its excellent performance on the wound healing promoting. However, there are several NPWT related cases which are caused by the unstable regulation of negative pressure have been reported. This has shown that there is a need to improve the performance of NPWT for reducing the NPWT wound injuries cases. Based on the review, the performance of NPWT is able to be improved with the incorporation of Fuzzy Logic based Negative Pressure Regulator (FL-NPR) but there are difficulties in the development of appropriate fuzzy sets setting for FL-NPR. This limitation could significantly affect the fuzziness of the algorithm and performance of NPWT. In this research, the Two Relationship Equation (2(n)RE) Fuzziness Adaptation approach for improving the performance of NPWT has been proposed. It is developed based on the theory of three-valued logic which can be applied for resolving the limitation of Classical Controller (CC). A set of Fuzzy based NPWT system with artificial wound model have been successfully developed with the support of experienced plastic surgeon. The research experiment of Fuzzy based NPWT with the proposed 2(n)RE Fuzziness Adaptation approach have been carried out. Based on the result obtained, it is clearly shown that the performance of NPWT can be significantly affected by the different fuzziness layer. The percentage of +/- 1 Tolerant Band achieved by the NPWT with 4RE FL-NPR is the highest where this result obtained is proving that the capability of wound healing process promoting of NPWT with 4RE FL-NPR is the highest. Furthermore, the percentage of undershoot achieved by the NPWT with 4RE FL-NPR is the lowest in which it is showing that its risk of low angiogenesis and wound healing failure is the lowest. According to the result obtained, the performance and safety feature of NPWT with 4RE FL-NPR is relatively better than that of 6RE FL-NPR and 8RE FL-NPR. In this research, the proposed 2(n)RE Fuzziness Adaptation approach for improving the performance and safety feature of NPWT have been successfully demonstrated and it is applicable for resolve the limitation of FL algorithm.
C1 [Hou, Tan Jia] Inst Engn & Technol, Stevenage, Herts, England.
   [Swee, Tan Tian; Hiik, Kelvin Ling Chia] Univ Teknol Malaysia, Fac Engn, Sch Biomed Engn & Hlth Sci, Johor Baharu, Malaysia.
   [Saad, Arman Zaharil Mat] Management & Sci Univ, Management & Sci Univ Hosp, Shah Alam, Malaysia.
   [Malik, Sameen Ahmed] Univ Engn & Technol Lahore, Fac Elect Engn, Dept Biomed Engn, Narowal Campus Narowal, Lahore 51600, Punjab, Pakistan.
C3 Universiti Teknologi Malaysia; Management Science University; University
   of Engineering & Technology Lahore
RP Hou, TJ (通讯作者)，Inst Engn & Technol, Stevenage, Herts, England.
EM jhtan@sc.edu.my; tantswee@biomedical.utm.my; lchkelvin2@live.utm.my;
   armanzaharil@gmail.com; sameen.ahmed@uet.edu.pk
RI Tan, Tian/G-6916-2013; Malik, Sameen/PJE-8009-2026; Ling Chia Hiik,
   Kelvin/AAW-9676-2021
OI Tan, Jia Hou/0000-0002-2419-5530; Ling Chia Hiik,
   Kelvin/0000-0003-1445-0507
FU Universiti Teknologi Malaysia and Management and Science University
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. The authors are
   grateful to the support provided by Universiti Teknologi Malaysia and
   Management and Science University.
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NR 34
TC 1
Z9 1
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0957-4174
EI 1873-6793
J9 EXPERT SYST APPL
JI Expert Syst. Appl.
PD DEC 1
PY 2022
VL 208
AR 118206
DI 10.1016/j.eswa.2022.118206
PG 19
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
   Electronic; Operations Research & Management Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering; Operations Research & Management Science
GA VN9PH
UT WOS:001259145700001
DA 2026-07-24
ER

PT J
AU Yang, LH
   Kong, J
   Xing, YL
   Pan, LF
   Li, CH
   Wu, ZX
   Li, MX
   Zhang, LB
AF Yang, Liehao
   Kong, Jiao
   Xing, Yunlong
   Pan, Lingfeng
   Li, Caihong
   Wu, Zhuoxia
   Li, Mingxi
   Zhang, Lianbo
TI Adjunctive hyperbaric oxygen therapy and negative pressure wound therapy
   for hard-to-heal wounds: a systematic review and meta-analysis
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE chronic wounds; hyperbaric oxygen therapy; meta-analysis; negative
   pressure wound therapy; systematic review; wound; wound care; wound
   dressing; wound healing
ID MANAGEMENT; CARE
AB Objective: Negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT) have been widely used in the treatment of hard- to-heal (chronic) wounds, but there is still a lack of sufficient evidence for their combined use for the treatment of hard-to-heal wounds. This systematic review aimed to identify the clinical efficacy and safety of adding adjunctive HBOT to NPWT for hard-to-heal wounds.<br /> Method: Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang were searched from the establishment of the database to March 2022. The literature was screened according to the inclusion criteria and exclusion criteria. We assessed the quality of each included study with the Cochrane Collaboration Risk of Bias tool and Newcastle-Ottawa Scale. A meta- analysis was performed using R programming software version 4.1.0 (R Project for Statistical Computing, US). The PRISMA 2020 guidelines were used to report data from systematic reviews and meta-analysis.<br /> Results: A total of 15 studies were identified, including nine randomised clinical controlled trials and six retrospective studies. Meta-analysis results showed that NPWT combined with HBOT had better outcomes compared with the NPWT alone with regards to: wound healing rate (odds ratio (OR)=6.77; 95% confidence interval (Cl): 3.53-12.98; p<0.0001); bacterial positive rate of wound (OR=0.16; 95% CI: 0.05-0.55; p=0.0037); wound healing time (mean difference (MD)= -3.86; 95% Cl: -5.18--2.53; p<0.0001); wound area (standardised mean difference (SMD)=1.50; 95% Cl: 0.35-2.65; p=0.0104); hospitalisation time (MD= - 3.14; 95% Cl: - 4.93- - 1.36; p=0.005); and hospitalisation cost (OR=-202.64; 95% Cl: -404.53--0.75; p=0.0492). There was no significant difference in pain score (MD= -0.43; 95% Cl: -1.15-0.30; p=0.25).<br /> Conclusion: The findings of this study demonstrated that adjunctive HBOT with NPWT is safe and effective in the treatment of hard-to- heal wounds. However, these findings should be interpreted with great caution given the limitations of the studies included.
C1 [Yang, Liehao; Kong, Jiao; Xing, Yunlong; Pan, Lingfeng; Li, Caihong; Wu, Zhuoxia; Li, Mingxi; Zhang, Lianbo] Jilin Univ, Dept Plast Surg, China Japan Union Hosp, Changchun, Peoples R China.
C3 Jilin University
RP Zhang, LB (通讯作者)，Jilin Univ, Dept Plast Surg, China Japan Union Hosp, Changchun, Peoples R China.
EM lianbo@jlu.edu.cn
RI Pan, Lingfeng/QQB-1441-2026
OI Li, Caihong/0009-0000-3728-6864; Yang, Liehao/0009-0009-4939-7292; Pan,
   Lingfeng/0009-0004-5846-3216
CR Lopes JRA, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04757-6
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NR 39
TC 5
Z9 7
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2024
VL 33
IS 12
BP 950
EP 957
DI 10.12968/jowc.2022.0213
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA R3Y9B
UT WOS:001390854500010
PM 39630554
DA 2026-07-24
ER

PT J
AU Imcha, M
   Liew, NC
   McNally, A
   Zibar, D
   O'Riordan, M
   Currie, A
   Styche, T
   Hughes, J
   Whittall, C
AF Imcha, Mendinaro
   Liew, Nyan Chin
   McNally, Arthur
   Zibar, Davor
   O'Riordan, Mairead
   Currie, Aoife
   Styche, Tim
   Hughes, Jacqui
   Whittall, Catherine
TI Single-use negative pressure wound therapy to prevent surgical site
   complications in high-risk patients undergoing caesarean sections: a
   real-world study
SO INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
LA English
DT Article
DE caesarean section; negative pressure wound therapy; surgical site
   infection; wound-related complications
ID INFECTION
AB Surgical site complications (SSCs), including surgical site infection (SSI), are common following C-sections. Management of the post-operative incision with single-use negative pressure wound therapy (sNPWT) has been shown to reduce the risk of SSC in high-risk individuals. This study explored the outcomes of routine, real-world use of sNPWT in high-risk patients undergoing C-sections.An observational, retrospective in-service evaluation was conducted across eight obstetric centres in the Republic and Northern Ireland. Patients undergoing C-sections were stratified for their risk of developing SSC using commonly known risk factors, including BMI >= 30, smoking, diabetes, and whether the patients had undergone previous C-sections or had a previous history of wound dehiscence. Those at high-risk were treated with sNPWT post-operatively. Data relating to any SSC that developed post-operatively, for up to 30 days, were captured. Data were compared with original research previously published by Wloch et al. (2012).Of 1111 women considered high-risk, 106 (9.5%) went on to develop SSCs, predominantly superficial SSIs. SSCs were associated with extra visits with their general practitioner (GP), outpatient visits, or inpatient hospital stays in 5.7%, 2.4%, and 1.7% of the entire cohort, representing 59.4%, 25.5%, and 17.9% of the 106 patients with SSC. Patients needed on average 1.8 extra GP visits and 0.7 extra outpatient visits. Patients who needed to be readmitted to hospital had an average length of stay of 4 days. In comparison with a previously published cohort, in which sNPWT was not used, we observed a significant reduction in the incidence of SSCs across BMI groups 18.5-24.9 (P = 0.02), 25-29.9 (P = 0.003), and >= 35 kg/m2 (P = 0.04). In those patients who had undergone at least one previous C-section, the rates of complications also reduced (P = 0.006).This analysis provides further justification for using sNPWT to manage surgical incisions in patients considered at high risk of developing post-procedural SSCs, particularly those with a BMI >= 30 or a history of more than one C-section.
C1 [Imcha, Mendinaro; Liew, Nyan Chin] Limerick Univ Matern Hosp, Obstet & Gynaecol, Ennis Rd, Limerick V94 C566, Ireland.
   [McNally, Arthur] Royal Jubilee Matern Hosp, Obstet & Gynaecol, 274 Grosvenor Rd, Belfast BT12 6BA, North Ireland.
   [Zibar, Davor] Univ Coll Hosp Galway, Obstet & Gynaecol, Newcastle Rd, Galway H91 YR71, Ireland.
   [O'Riordan, Mairead] Cork Univ Matern Hosp, Obstet & Gynaecol, Wilton Rd, Cork T12 YE02, Ireland.
   [Currie, Aoife] Craigavon Area Hosp, Obstet & Gynaecol, 68 Lurgan Rd, Craigavon BT63 5QQ, North Ireland.
   [Styche, Tim; Hughes, Jacqui; Whittall, Catherine] Smith & Nephew, Global HEOR, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
C3 Smith & Nephew
RP Whittall, C (通讯作者)，Smith & Nephew, Global HEOR, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, England.
EM Catherine.whittall@smith-nephew.com
RI Whittall, Catherine/AAW-8323-2021
OI Whittall, Catherine/0000-0003-4859-4293; Hughes,
   Jacqui/0000-0003-2413-0654
FU Clinicians, Katherine Ivery, Gemma Ferguson, Lyndsay Creswell (Royal
   Jubilee Maternity Hospital, Belfast, UK), Vineta Ciprike, Etop Akpan,
   Ream Langhe (Our Lady of Lourdes Hospital, Drogheda, Republic of
   Ireland), Geraldine Gaffney, Lorentina Schaeler (Uni; (University
   College Hospital Galway, Galway, Republic of Ireland)
FX Clinicians, Katherine Ivery, Gemma Ferguson, Lyndsay Creswell (Royal
   Jubilee Maternity Hospital, Belfast, UK), Vineta Ciprike, Etop Akpan,
   Ream Langhe (Our Lady of Lourdes Hospital, Drogheda, Republic of
   Ireland), Geraldine Gaffney, Lorentina Schaeler (University College
   Hospital Galway, Galway, Republic of Ireland), Marie Christine De
   Tavernier, Barend Botha (Portiuncula University Hospital, Portincula,
   Republic of Ireland), Heather Langan and Rasha Ibhram (Sligo University
   Hospital, Sligo, Republic of Ireland), provided patient care, data
   collection and staff training in the respective centres, that
   underpinned this evaluation. Editorial services were provided by JMS
   Medical Writing Services Ltd.
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NR 26
TC 6
Z9 6
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1353-4505
EI 1464-3677
J9 INT J QUAL HEALTH C
JI Int. J. Qual. Health Care
PD OCT 31
PY 2023
VL 35
IS 4
AR mzad089
DI 10.1093/intqhc/mzad089
EA OCT 2023
PG 7
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA W9PI5
UT WOS:001094873800002
PM 37930777
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Thorbjornsen, K
   Gidlund, KD
   Björck, M
   Kragsterman, B
   Wanhainen, A
AF Thorbjornsen, K.
   Gidlund, K. Djavani
   Bjorck, M.
   Kragsterman, B.
   Wanhainen, A.
TI Editor's Choice - Long-term Outcome After EndoVAC Hybrid Repair of
   Infected Vascular Reconstructions
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE Access site infection; Hybrid technique; Negative pressure wound
   therapy; Stent graft; Vacuum assisted wound closure; Vascular graft
   infection
ID ASSISTED WOUND CLOSURE; DACRON PATCH INFECTION; OF-THE-LITERATURE;
   PROSTHETIC GRAFT INFECTIONS; MYCOTIC AORTIC-ANEURYSMS; MUSCLE FLAP
   COVERAGE; CAROTID-ENDARTERECTOMY; SYNTHETIC GRAFTS; GROIN INFECTIONS;
   MANAGEMENT
AB Objective/Background: Vascular graft infection is a serious and challenging complication. In situations when neither traditional radical surgery nor conservative negative pressure wound therapy (VAC) alone, are considered feasible or safe, for example due to bleeding, adverse anatomy, or severe comorbidity, a novel hybrid procedure was developed. The EndoVAC technique consists of (i) relining of the infected reconstruction with a stent graft; (ii) surgical revision (without clamping the reconstruction); and (iii) VAC therapy, to permit granulation and secondary delayed healing, and long-term antibiotic treatment. The aim of the study is to report long-term follow up data of this new treatment modality.
   Methods: From November 2007 to June 2015, 17 EndoVAC procedures were performed in 16 patients (eight men, aged 16-91 years): six infected carotid patches after carotid endarterectomy, three infected neck deviations, two infected femoro-popliteal bypasses, three infected patches after femoral thrombo-endarterectomy, and two infected vascular accesses. Surveillance was performed routinely every 3-6 months and included clinical examination, hematologic tests, duplex ultrasonography, and imaging techniques, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography.
   Results: Primary technical success rate was 100%. Antibiotics were prescribed for a median of 3 months (range 1-20 months). The median duration of VAC treatment was 14 days (range 9-57 days). Complications included early, transient stroke (n = 1), temporary hypoglossal palsy (n = 1), and late, asymptomatic occluded bypasses (n = 2), stent graft thrombosis (n = 1), and moderate carotid stenosis (n = 1). After a median of 5 years (range 1-90 months) of follow up, all patients had healed graft infections with no recurrence was observed. Eight patients died as a result of severe comorbidities, unrelated to the infection or hybrid procedure, 1 month 7 years after treatment.
   Conclusion: The EndoVAC technique is an alternative, less invasive, option for treatment of infected vascular reconstructions in selected cases, when neither traditional radical surgery, nor conservative simple negative pressure wound therapy are considered feasible or safe. The exact indications for this alternative hybrid treatment need to be established. (C) 2016 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Thorbjornsen, K.; Gidlund, K. Djavani; Bjorck, M.; Kragsterman, B.; Wanhainen, A.] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
   [Thorbjornsen, K.; Gidlund, K. Djavani] Uppsala Univ, Cty Council Gavleborg, Ctr Res & Dev, Gavle, Sweden.
C3 Uppsala University; Uppsala University
RP Wanhainen, A (通讯作者)，Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
EM anders.wanhainen@surgsci.uu.se
OI Thorbjørnsen, Knut/0000-0003-4404-5406
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NR 41
TC 21
Z9 24
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD MAY
PY 2016
VL 51
IS 5
BP 724
EP 732
DI 10.1016/j.ejvs.2016.01.011
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA DM2YI
UT WOS:000376213600023
PM 26944600
DA 2026-07-24
ER

PT J
AU Carrano, FM
   Maroli, A
   Carvello, M
   Foppa, C
   Sacchi, M
   Crippa, J
   Clerico, G
   De Lucia, F
   Coppola, E
   Ben David, N
   Spinelli, A
AF Carrano, Francesco M.
   Maroli, Annalisa
   Carvello, Michele
   Foppa, Caterina
   Sacchi, Matteo
   Crippa, Jacopo
   Clerico, Giuseppe
   De Lucia, Francesca
   Coppola, Elisabetta
   Ben David, Nadav
   Spinelli, Antonino
TI Negative-pressure wound therapy after stoma reversal in colorectal
   surgery: a randomized controlled trial
SO BJS OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; SHORT-TERM OUTCOMES; POSTOPERATIVE
   COMPLICATIONS; ILEOSTOMY CLOSURE; SKIN CLOSURE; RISK-FACTORS; MORBIDITY;
   PREVENTION; RESECTION; DISEASE
AB The use of negative-pressure wound therapy (NPWT) does not reduce the incidence of surgical-site infections after stoma-reversal surgery; however, its application reduces healing times, provides superior comfort for the patient, reduces wound pain and leads to better aesthetic outcomes compared with standard purse-string suture technique. This is the first randomized trial evaluating pain and discomfort with the application of NPWT in stoma reversal.
   Background Stoma-reversal surgery is associated with high postoperative morbidity, including wound complications and surgical-site infections (SSIs). This study aims to assess whether the application of negative-pressure wound therapy (NPWT) can improve wound healing compared with conventional wound dressing. Methods This was a single-centre, superiority, open-label, parallel, individually randomized controlled trial. Patients undergoing stoma reversal were randomized (1 : 1) to receive NPWT or conventional wound dressing. The primary endpoint of the study was the rate of wound complications and SSIs after stoma closure. The secondary endpoints were postoperative wound pain, rate of wound healing after 30 days from stoma closure, and wound aesthetic satisfaction. Results Between June 2019 and January 2021, 50 patients were allocated to the NPWT group (all received NPWT, 49 were analysed); 50 patients were allocated to the conventional wound dressing group (48 received the treatment, 45 were analysed). No significant difference was found in wound-complication rate (10 per cent NPWT versus 16 per cent controls; odds ratio 0.61 (95 per cent c.i. 0.18 to 2.10), P = 0.542) and incisional SSI rate (8 per cent NPWT versus 7 per cent controls; odds ratio 1.24 (95 per cent c.i. 0.26 to 5.99), P = 1.000). The NPWT group showed less pain, higher aesthetic satisfaction (P < 0.0001), and a higher proportion of wound healing (92 versus 78 per cent; P = 0.081) compared with the control group. Conclusion NPWT does not reduce the incidence of SSI after stoma-reversal surgery compared with conventional wound dressing. However, NPWT improved the healing of uninfected wounds, reduced wound pain and led to better aesthetic outcomes. Registration number: NCT037812016 (clinicaltrials.gov).
C1 [Carrano, Francesco M.; Maroli, Annalisa; Carvello, Michele; Foppa, Caterina; Sacchi, Matteo; Crippa, Jacopo; Clerico, Giuseppe; De Lucia, Francesca; Coppola, Elisabetta; Ben David, Nadav; Spinelli, Antonino] Humanitas Univ, Dept Biomed Sci, Milan, Italy.
   [Spinelli, Antonino] IRCCS Humanitas Res Hosp, Div Colon & Rectal Surg, Milan, Italy.
C3 Humanitas University
RP Spinelli, A (通讯作者)，IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Rozzano, MI, Italy.
EM antonino.spinelli@hunimed.eu
RI Carrano, Francesco Maria/AAB-6807-2021; Foppa, Caterina/AAC-2327-2020;
   Crippa, Jacopo/AAC-5116-2019; DE LUCIA, FRANCESCA/LWK-7416-2024; MAROLI,
   ANNALISA/IAR-5529-2023; carvello, michele maria/HHN-5282-2022; SACCHI,
   MATTEO/J-7484-2018; Spinelli, Antonino/ABI-1441-2020
OI MAROLI, ANNALISA/0000-0002-7576-9629; carvello, michele
   maria/0000-0002-8650-2321; SACCHI, MATTEO/0000-0001-8313-4909; Spinelli,
   Antonino/0000-0002-1493-1768
FU SmithNephew S.R.L.
FX This study was funded by Smith&Nephew S.R.L., which provided a research
   grant covering the trial-specific expenses (including patient insurance,
   hosting of the electronic case report form, and NPWT devices).
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NR 32
TC 29
Z9 33
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD NOV 9
PY 2021
VL 5
IS 6
AR zrab116
DI 10.1093/bjsopen/zrab116
EA DEC 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA YW0LP
UT WOS:000753113400035
PM 34904647
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Reed, T
AF Reed, Terri
TI The Use of Multiple Negative Pressure Wound Therapy Modalities to Help
   Manage Extensive Wounds Caused by a Crush/Sheer Injury
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; acute
   wounds; trauma; lower extremity wound
AB Introduction. Vehicular run-over accidents cause crushing and sheering forces that can result in fractures and cause extensive damage to the cutaneous layer of the skin and underlying soft tissues. These types of injuries present immense challenges that often require numerous treatment modalities for wound management. A complex case in which 2 distinct negative pressure wound therapy (NPWT) modalities were instrumental in helping manage extensive wounds resulting from extreme crushing/sheering forces is presented. Case Report. A 22-year-old male without prior medical history presented to the treating facility after falling and being crushed by a parade float. The patient had multiple fractures to the facial area and pelvic region, including the left side of the sacrum. The injuries encompassed the entire perineum, rectal area, scrotum, and both upper legs. After stabilizing the patient, attention was directed to the extensive wound and eventual closure. Following muscle flap reconstructions to help protect the left and right femoral arteries, an acellular artificial skin was placed to cover the perineum, bilateral medial thighs, and left groin region. Upon developing wound complications, NPWT with instillation and dwell time (NPWTi-d) was applied by intermittently instilling 60 mL of normal saline solution with a 10-minute dwell time, followed by negative pressure at -125 mm Hg for 3.5 hours. The therapy was applied for 11 days with dressing changes every 2 to 3 days. The patient then underwent split-thickness skin grafting to the left thigh, perineum, and right thigh. Due to the extensive nature of the wounds and the multiple anatomical locations, a novel 4-channel NPWT system was used as a bolster over the skin grafts. Continuous NPWT was applied at -125 mm Hg for 2 weeks with dressing changes occurring every 2 to 3 days. There was complete take of all skin grafts 17 days post-grafting, and the patient has since healed. The patient is now walking and has resumed normal daily activities. Conclusions. For this case, combining treatment modalities was beneficial in healing a patient's complex trauma wounds and shows a potential treatment strategy in this population of wounds.
C1 [Reed, Terri] Barnes Jewish Hosp, Wound Ost, 1 Barnes Jewish Hosp Plaza, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Barnes-Jewish Hospital
RP Reed, T (通讯作者)，Barnes Jewish Hosp, Wound Ost, 1 Barnes Jewish Hosp Plaza, St Louis, MO 63110 USA.
EM terri.reed@BJC.org
CR Anghel EL, 2016, INT WOUND J, V13, P19, DOI 10.1111/iwj.12664
   Kaplan M, 2009, ADV SKIN WOUND CARE, V22, P128, DOI 10.1097/01.ASW.0000305451.71811.d5
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Omar M, 2016, J WOUND CARE, V25, P475, DOI 10.12968/jowc.2016.25.8.475
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
NR 5
TC 1
Z9 1
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2020
VL 32
SU S
BP 369
EP 371
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SR8KO
UT WOS:000661294500002
PM 33472163
DA 2026-07-24
ER

PT J
AU De Pellegrin, L
   Zucal, I
   Treglia, G
   Parodi, C
   Schweizer, R
   De Monti, M
   Harder, Y
AF De Pellegrin, Laura
   Zucal, Isabel
   Treglia, Giorgio
   Parodi, Corrado
   Schweizer, Riccardo
   De Monti, Marco
   Harder, Yves
TI Salvage of the Mastectomy Pocket in Infected Implant-Based Breast
   Reconstruction Using Negative-Pressure Wound Therapy with Instillation
   and Dwell: A Systematic Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE negative-pressure wound therapy; NPWTi-d; breast reconstruction; breast
   implant; periprosthetic breast infection
ID CAPSULAR CONTRACTURE; MANAGEMENT; RATES
AB Background: Breast cancer, irrespective of gender, stands as the most prevalent cancer globally, with an annual estimate of 2.3 million new cases. Surgical intervention, including therapeutic mastectomy (excluding prophylactic procedures), is performed on approximately 28% of patients, necessitating subsequent breast reconstruction. Although implant-based breast reconstruction (IBBR) is frequently employed due to its relative ease compared to autologous methods, it presents a notable risk for complications at mid-term such as peri-prosthetic infections. These complications can lead to implant loss and the eventual compromise of the mastectomy pocket. To address these complications, negative pressure wound therapy with instillation and dwell (NPWTi-d) emerges as a promising rescue intervention, known for its capacity to significantly reduce bacterial load and potentially salvage compromised soft tissues. However, the evidence supporting its effectiveness in infected pockets after mastectomy is currently insufficient. This study aims at investigating the efficacy of NPWTi-d in the management of peri-prosthetic mastectomy pocket infection. Methods: A thorough literature search has been concluded through PubMed, Web of Science, and Cochrane databases up until 18th March 2025 on evaluating NPWTi-d's ability to manage peri-prosthetic infections and preserve mastectomy pockets for subsequent reconstruction. Furthermore, a meta-analysis on the salvage rate of the mastectomy pocket was carried out, while for other outcomes, a descriptive analysis was applied. Results: Nine studies (n = 230 patients) were included, investigating whether the us NPWTi-d was successful in treating peri-prosthetic infection and preserving the mastectomy pocket for subsequent reconstruction by expander or implant. The pooled salvage rate of the implant-based BR due to the use of NPWTi-d was 86.1% (95%CI: 80.6-91.6%). Preservation of the skin envelope avoided secondary reconstruction after a defined time interval, reducing number and complexity of surgeries and related costs. Conclusions: This innovative surgical approach should be considered in selected cases of infected implants after breast reconstruction in breast cancer centers. However, the actual low level of evidence is based on case series, and it is not possible to define generally accepted recommendations for the use of NPWTi-d to save the mastectomy pocket.
C1 [De Pellegrin, Laura; Zucal, Isabel; Parodi, Corrado; Schweizer, Riccardo; De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Lugano, Dept Plast Reconstruct & Aesthet Surg EOC, CH-6900 Lugano, Switzerland.
   [Treglia, Giorgio] Univ Svizzera Italiana, Fac Biomed Sci, CH-6900 Lugano, Switzerland.
   [Treglia, Giorgio] Ente Osped Cantonale EOC, Div Med Educ & Res, CH-6500 Bellinzona, Switzerland.
   [Schweizer, Riccardo] Luzerner Kantonsspital, Dept Hand Surg & Plast Surg, CH-6000 Luzern, Switzerland.
   [De Monti, Marco] Ente Osped Cantonale EOC, Osped Reg Mendrisio, Dept Gen Surg, CH-6850 Mendrisio, Switzerland.
   [Harder, Yves] Univ Hosp Lausanne CHUV, Dept Plast Reconstruct & Aesthet Surg & Hand Surg, CH-1011 Lausanne, Switzerland.
   [Harder, Yves] Univ Lausanne UNIL, Fac Biol & Med, CH-1015 Lausanne, Switzerland.
C3 Universita della Svizzera Italiana; Lucerne Cantonal Hospital;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne
RP Harder, Y (通讯作者)，Univ Hosp Lausanne CHUV, Dept Plast Reconstruct & Aesthet Surg & Hand Surg, CH-1011 Lausanne, Switzerland.; Harder, Y (通讯作者)，Univ Lausanne UNIL, Fac Biol & Med, CH-1015 Lausanne, Switzerland.
EM laura.depellegrin@gmx.de; isabel.zucal@eoc.ch; giorgio.treglia@eoc.ch;
   corrado.parodi@eoc.ch; marco.demonti@eoc.ch; yves.harder@chuv.ch
RI ; Treglia, Giorgio/I-2727-2013; De Monti, Marco/HJI-5543-2023; Zucal,
   Isabel/IZD-4908-2023
OI Harder, Yves/0000-0002-2557-249X; Treglia, Giorgio/0000-0001-9808-780X;
   De Monti, Marco/0000-0003-0927-3438; Schweizer,
   Riccardo/0000-0002-5686-8496; De Pellegrin, Laura Silvia
   Caterina/0009-0004-6010-7886
CR Accurso A, 2017, AESTHET PLAST SURG, V41, P36, DOI 10.1007/s00266-016-0739-1
   Ahmed S, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000006116
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NR 36
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 16
PY 2025
VL 14
IS 8
AR 2730
DI 10.3390/jcm14082730
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1WY6T
UT WOS:001475624900001
PM 40283560
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Hou, SL
   Shi, ZY
   Li, XW
   Yang, R
   Song, Y
   Zeng, ZL
AF Hou, Shulin
   Shi, Zeyao
   Li, Xiaowen
   Yang, Ru
   Song, Yan
   Zeng, Zhaolan
TI Combined negative pressure wound therapy with new wound dressings to
   repair a ruptured giant omphalocele in a neonate: a case report and
   literature review
SO BMC PEDIATRICS
LA English
DT Article
DE Negative pressure wound therapy; Infant, Newborn; Giant omphalocele
ID FIBROBLAST-GROWTH-FACTOR; MANAGEMENT
AB BackgroundCurrent treatment of giant omphalocele in newborns is not standardized. The main treatments include one-time repair and staged surgery using synthetic and biologic mesh, or silos. However, surgery can lead to various postoperative complications. Recently, negative pressure wound therapy (NPWT) has been recommended as an effective method for giant omphalocele. We adopted NPWT and some new wound dressings for a case of ruptured giant omphalocele. Vaseline gauze (VG), followed by silver-containing sodium carboxymethylcellulose dressing(CMC-Ag)was used to control infection. NPWT was mainly performed to promote granulation and accelerated healing. Recombinant human basic fibroblast growth factor (Rh-bFGF) was used to heal the wound. No studies have conducted NPWT and new wound dressings healing the wound of ruptured giant omphalocele. Therefore, we present our management experience in this case.Case presentationThe patient was a baby boy aged 2 days, weighing 2930 g. He was diagnosed with a giant omphalocele with a partial intestine exposed. Two hours after admission, the baby underwent a silo placement. The herniation of the bowel was gradually reduced into the abdominal cavity. At the age of 13 days, the stitches at the bottom of the silo fell off, and the liver was exposed with the defect size about 8 cm x 10 cm. The hole failed to be repaired by surgery. We used VG and CMC-Ag patched on the defect hole. After creating a moist and fresh environment, NPWT was then applied mainly to extract excess fluid and promote granulation. CMC-Ag was performed for 19 days when the wound showed no exudate or infection. NPWT was stopped at the age of 47 days when the granulation tissue was fully formed with the defect size reduced to 4.5 cm x 3.5 cm. After halting the NPWT, the wound was managed with Rh-bFGF and VG. At the age of 2 months, the wound was reduced to 1 cm x 1 cm with satisfactory epithelialization.ConclusionsNPWT is a safe and effective alternative therapy for the repair of giant omphalocele. CMC-Ag can help control wound infection and manage exudate and Rh-bFGF promotes wound healing. NPWT combined with new wound dressings can effectively manage ruptured giant omphalocele.Clinical trial numberNot applicable.
C1 [Hou, Shulin; Shi, Zeyao; Li, Xiaowen; Yang, Ru; Song, Yan; Zeng, Zhaolan] Sichuan Univ, West China Second Univ Hosp, Dept Neonatol Nursing, 20,Sect 3,South Renmin Rd, Chengdu, Sichuan Provinc, Peoples R China.
   [Hou, Shulin; Shi, Zeyao; Li, Xiaowen; Yang, Ru; Song, Yan; Zeng, Zhaolan] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Shi, ZY; Li, XW (通讯作者)，Sichuan Univ, West China Second Univ Hosp, Dept Neonatol Nursing, 20,Sect 3,South Renmin Rd, Chengdu, Sichuan Provinc, Peoples R China.; Shi, ZY; Li, XW (通讯作者)，Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
EM zeyao-shi@scu.edu.cn; 976682704@qq.com
OI Junco, Judy Von/0009-0003-5977-5249
CR Abello C, 2021, J PEDIATR SURG, V56, P1068, DOI 10.1016/j.jpedsurg.2020.12.003
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NR 33
TC 5
Z9 6
U1 1
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD JAN 18
PY 2025
VL 25
IS 1
AR 44
DI 10.1186/s12887-024-05261-5
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA S5Z6B
UT WOS:001399002800002
PM 39825289
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, R
   Na, H
   Cheng, SW
   Zeng, YF
AF Wang, Rong
   Na, Han
   Cheng, Shaowen
   Zeng, Yunfu
TI Effect of Compound Xuejie Powder combined with negative pressure wound
   therapy on diabetic foot ulcers and blood flow in the dorsal foot artery
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Compound dried blood powder; negative pressure wound therapy; diabetic
   foot; ulcer; dorsal foot artery blood flow; local inflammation
AB Objective: To observe the therapeutic effect of Compound Xuejie Powder combined with negative pressure wound therapy (NPWT) on diabetic foot ulcers and its influence on the blood flow of the dorsal artery in the foot. Methods: A total of 103 patients with diabetic foot ulcers, admitted to our hospital between February 2021 and March 2023, were included in this study. The control group was given NPWT on the basis of conventional treatment such as controlling blood sugar and blood pressure, anti-infection therapy and improving blood circulation, while the observation group was given Compound Xuejie Powder combined with NPWT on the basis of conventional treatment. The two groups were compared in terms of granulation tissue coverage and thickness, wound healing time, levels of inflammatory factors related to Notch signaling pathway in wound exudation, serum angiogenesis factors, and dorsal foot artery blood flow. Results: Before treatment, there were no significant differences between the two groups in the levels of inflammatory factors related to the Notch signaling pathway in wound exudates or serum angiogenesis factors (all P>0.05). After treatment, vascular endothelial growth factor (VEGF) level increased, while the levels of TNF-alpha, IL-1 beta, IL-6, IL-17 and chemoattractant factor (pigment epithelium-derived factor, PEDF) decreased in both groups, an these alterations in the observation group were more pronounced compared to the control group (all P<0.05). There was no significant difference in dorsal foot artery blood flow before treatment (all P>0.05); however, Vm, PI, RI and vascular diameter were notably increased in both groups after the treatment, with more pronounced improvements noticed in the observation group (all P<0.05). The total effective rate, granulation tissue coverage rate, and granulation tissue thickness were significantly higher while wound healing time was significantly shorter in the observation group compared to the control group (all P<0.05). Conclusion: In the treatment of diabetic foot ulcers, Compound Xuejie Powder combined with NPWT can effectively inhibit local inflammation, improve the blood flow of the dorsal foot artery and promote ulcer healing.
C1 [Wang, Rong; Cheng, Shaowen; Zeng, Yunfu] Hainan Med Univ, Affiliated Hosp 1, Dept Wound Repair, 31 Longhua Rd, Haikou 570100, Hainan, Peoples R China.
   [Na, Han] Hainan Med Univ, Affiliated Hosp 1, Dept Endocrinol, Haikou 570102, Hainan, Peoples R China.
C3 Hainan Medical University; Hainan Medical University
RP Zeng, YF (通讯作者)，Hainan Med Univ, Affiliated Hosp 1, Dept Wound Repair, 31 Longhua Rd, Haikou 570100, Hainan, Peoples R China.
EM yunfuzeng84090@163.com
FU Hainan Provincial Natural Science Foundation [822 QN463, 822MS174];
   Hainan Province Health Industry Research Project [22A200051]
FX This work was supported by the Hainan Provincial Natural Science
   Foundation (822 QN463, 822MS174) and Hainan Province Health Industry
   Research Project (22A200051) .
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NR 21
TC 1
Z9 1
U1 2
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 9
BP 4996
EP 5003
DI 10.62347/XSXY3749
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA I0I0Z
UT WOS:001327170100065
PM 39398571
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Abul, A
   Abel, A
   Al-Saffar, M
   Iskeirjeh, S
   Badran, S
AF Abul, Ahmad
   Abel, Ali
   Al-Saffar, Mohammad
   Iskeirjeh, Sara
   Badran, Saif
TI Efficacy of closed-incision negative pressure wound therapy in
   abdominal-based autologous breast reconstruction: A systematic review
   and meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Closed-incision Negative Pressure Wound Therapy; CiNPWT; DIEP flap;
   Donor site morbidity; Postoperative complications; Breast reconstruction
ID DONOR-SITE COMPLICATIONS; MANAGEMENT; IMPACT
AB Introduction: Abdominal-based free tissue transfers, such as the Deep Inferior Epigastric Perforator (DIEP) flap, are widely utilized in autologous breast reconstruction. These procedures are often complicated by wound healing issues at the donor site, including wound dehiscence, seroma formation, and surgical site infections (SSIs). Closed Incision Negative Pressure Wound Therapy (ciNPWT) has been suggested to improve healing outcomes and reduce the incidence of postoperative complications. This synthesis evaluated the efficacy of ciNPWT compared to standard dressings in abdominal-based autologous breast reconstruction. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Randomized controlled trials and observational studies assessing ciNPWT versus standard dressings in patients undergoing abdominal-based free flap breast reconstruction were included. Primary and secondary outcomes analyzed were wound dehiscence, SSIs, seroma formation, and length of stay. Data from multiple databases were independently reviewed and synthesized using Review Manager 5.4 and Microsoft Excel. Studies were rigorously selected and assessed for risk of bias. Results: Of the 348 identified articles, 13 studies met the inclusion criteria, comprising three randomized controlled trials and 10 observational studies, totaling 2882 patients. The ciNPWT group showed a 42% reduction in wound dehiscence (OR 0.58, 95% CI 0.42-0.79; p = 0.0007), with moderate heterogeneity (I2 = 36%). No significant differences were found for surgical site infections (OR 0.77, 95% CI 0.50-1.18; p = 0.23) and seroma formation (OR 0.66, 95% CI 0.38-1.12; p = 0.15). Variations in length of stay data prevented quantitative analysis. Conclusion: ciNPWT demonstrates a significant reduction in wound dehiscence, highlighting its value in enhancing postoperative care, especially for high-risk patients. However, further research involving larger, multicenter randomized controlled trials is necessary to fully elucidate ciNPWT's role in reducing other complications and its broader clinical applicability. (c) 2025 The Author(s). Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Abul, Ahmad; Al-Saffar, Mohammad] Jaber Al Ahmad Hosp, Dept Plast & Reconstruct Surg, Minist Hlth, Kuwait, Kuwait.
   [Abel, Ali] Ibn Sina Hosp, Al Babtain Ctr Burns & Plast Surg, Minist Hlth, Kuwait, Kuwait.
   [Iskeirjeh, Sara] Hamad Gen Hosp, Hamad Med Corp, Dept Plast & Reconstruct Surg, Doha, Qatar.
   [Badran, Saif] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Australia.
   [Badran, Saif] Washington Univ, Sch Med, Div Plast & Reconstruct Surg, St Louis, MO USA.
C3 Hamad Medical Corporation; Hamad General Hospital; Flinders University;
   Washington University (WUSTL)
RP Badran, S (通讯作者)，Washington Univ, Dept Surg, Div Plast Surg, Div Surg Sci,Sch Med, 660 S Euclid Ave, St. Louis, MO 63110 USA.
EM badran@wustl.edu
OI Abul, Ahmad/0000-0003-3242-2630; Iskeirjeh, Sara/0009-0009-1128-3847;
   Badran, Saif/0000-0002-5955-1734
CR Abraham MT, 2024, Aesthetic Plast Surg, V48, P579, DOI [10.1007/s00266-023-03475-y, DOI 10.1007/S00266-023-03475-Y]
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NR 28
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2025
VL 107
BP 151
EP 161
DI 10.1016/j.bjps.2025.06.032
EA AUG 2025
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4XL4K
UT WOS:001528980400001
PM 40617064
OA hybrid
DA 2026-07-24
ER

PT J
AU Tang, Y
   Ji, H
   Yan, YY
   Hu, D
   Xu, MR
   Xu, M
   Zhao, XT
   Chen, MW
AF Tang, Ying
   Ji, Hua
   Yan, Yanyan
   Hu, Die
   Xu, Murong
   Xu, Min
   Zhao, Xiaotong
   Chen, Mingwei
TI Enhancing diabetic foot ulcer healing: Impact of the regulation of the
   FUS and ILF2 RNA-binding proteins through negative pressure wound
   therapy
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE diabetic foot ulcer; negative pressure wound therapy; wound healing;
   keratinocyte; RNA-binding protein; FUS; ILF2; RNA sequencing
ID MATRIX; EPIDEMIOLOGY; EXPRESSION; CANCER; GENE; TIME
AB Diabetic foot ulcer (DFU) is a destructive complication of diabetes. Negative pressure wound therapy (NPWT) promotes DFU wound healing through an undetermined mechanism. In the present study, RNA sequencing was performed on wound granulation tissue from 3 patients with DFU before and after 1 week of NPWT. The fused in sarcoma (FUS) and interleukin enhancer binding factor 2 (ILF2) encoding RNA-binding proteins (RBPs) were screened from the sequencing data, and wound tissue samples from 24 patients with DFU were validated and analyzed before and after receiving NPWT by reverse transcription-quantitative PCR, western blotting and immunohistochemistry. In addition, in vitro and in vivo experiments were conducted to determine the effect of the expression of FUS and ILF2 on the function of human epidermal keratinocyte cells (HaCaT cells) and the healing of diabetic skin wounds. The results indicated that NPWT induced the upregulation of 101 genes and the downregulation of 98 genes in DFU wound granulation tissue. After NPWT, the expression of FUS and ILF2 was significantly upregulated (P<0.05). Pearson's correlation coefficient showed that the changes in FUS and ILF2 before and after NPWT were negatively correlated with changes in white blood cells, the neutrophil percentage, C-reactive protein, tumor necrosis factor-alpha, reactive oxygen species, lipid peroxides, matrix metalloproteinase (MMP) 2 and MMP9 (P<0.05), but positively correlated with the anti-inflammatory factor, IL-4 (P<0.01). There was also a positive correlation (P<0.05) with the 4-week ulcer healing rate. Additionally, the knockdown of FUS and ILF2 expression inhibited the proliferation and migration of HaCaT cells, while increasing cell apoptosis. In vivo, the knockdown of FUS and ILF2 significantly reduced the rate of skin wound healing in diabetic mice. The results of the present study therefore provide new insights into the mechanism by which NPWT promotes DFU wound healing. In conclusion, the RBPs, FUS and ILF2, promoted DFU wound healing by regulating the function of keratinocytes and reducing the inflammatory response and oxidative stress.
C1 [Tang, Ying; Ji, Hua; Yan, Yanyan; Hu, Die; Xu, Murong; Xu, Min; Zhao, Xiaotong; Chen, Mingwei] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University
RP Zhao, XT; Chen, MW (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230032, Anhui, Peoples R China.
EM zxt522154846@163.com; chmw1@163.com
RI ; HU, Die-hua/IAR-3636-2023; Xu, Murong/HHS-2387-2022
OI ji, hua/0000-0002-7441-7963; 
FU Natural Science Foundation of Anhui Province in China
FX Not applicable.
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NR 74
TC 3
Z9 3
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2024
VL 54
IS 5
AR 103
DI 10.3892/ijmm.2024.5427
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA G8T9F
UT WOS:001319305900001
PM 39301661
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Yilmaz, M
   Thorn, A
   Sorensen, MS
   Jensen, CL
   Petersen, MM
AF Yilmaz, Mujgan
   Thorn, Andrea
   Sorensen, Michala Skovlund
   Jensen, Claus Lindkaer
   Petersen, Michael Mork
TI Effect of negative pressure wound therapy after surgical removal of
   deep-seated high-malignant soft tissue sarcomas of the extremities and
   trunk wall-study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Sarcoma; Soft tissue sarcoma; Negative pressure wound therapy; Prevena
   (TM); Extremity; Trunk wall
ID RISK-FACTORS; COMPLICATION; HIP
AB Background: Sarcomas are a heterogeneous group of rare malignant tumors of mesenchymal origin in the musculoskeletal system. The main treatment is surgery often supplemented with pre-or postoperative radiotherapy.
   A retrospective study by Bedi et al. indicated that negative pressure wound therapy (NPWT) reduced the risk of postoperative wound complications in patients treated with preoperative radiation followed by surgical tumor removal of lower extremity soft tissue sarcomas (STS), and the use of NPWT was not associated with an increased risk of local recurrence. Previous studies have shown that NPWT can reduce postoperative complications. STS surgeries are a high-risk procedure concerning wound complications.
   Methods: Non-blinded single-center randomized controlled trial comparing NPWT versus conventional wound dressing and postoperative wound complications after surgical removal of deep-seated high-malignant STS of the extremities or trunk wall
   Sample-size calculation: 154 STS patients (80% risk of avoiding type II error, 5% risk of type I error, and an 80% wound complication risk)
   Block randomization of 8 into:
   Group A: Conventional wound dressing
   Group B: NPWT (PREVENA PLUS (TM) Incision Management System)
   Inclusion criteria: Surgery for a deep-seated STS of an extremity or the trunk wall
   Exclusion criteria: Age < 18 years, plastic surgery, low malignant/borderline STS, chemotherapy, preoperative radiotherapy, allergic/hypersensitive to acrylic adhesives or silver, unwilling/unable to provide informed consent, metastatic disease, and ischemic surgeries
   Primary study endpoints were set as major wound complications defined by O'Sullivan et al. as a secondary surgery under anesthesia for wound repairs and wound management without secondary surgery within 4 months postoperatively.
   Secondary study endpoints among others are Musculoskeletal Tumor Society Score (MSTS), Toronto Extremity Salvage Score (TESS), and European Quality of Life - 5 Dimensions (EQ-5D).
   Approval from the Scientific Ethical Committee and the Data Protection Agency has been obtained, and the study is registered at clinicaltrial.gov.
   This study did not apply for external funding.
   Discussion: Many new medical devices and technical solutions are currently being introduced, and even though some documentation regarding the use of NPWT, e.g., in joint replacement surgery exist, it is also important to seek documentation for this treatment principle in STS surgery.
C1 [Yilmaz, Mujgan; Thorn, Andrea; Sorensen, Michala Skovlund; Jensen, Claus Lindkaer; Petersen, Michael Mork] Univ Hosp Copenhagen, Rigshosp, Dept Orthoped Surg, Inge Lehmanns Vej 6, DK-2100 Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University Hospital
RP Yilmaz, M (通讯作者)，Univ Hosp Copenhagen, Rigshosp, Dept Orthoped Surg, Inge Lehmanns Vej 6, DK-2100 Copenhagen, Denmark.
EM yilmaz_mujgan@hotmail.com
OI Yilmaz, Müjgan/0000-0002-1822-0453; Petersen, Michael
   Mørk/0000-0002-2324-6420; Sørensen, Michala Skovlund/0000-0003-0123-2666
FU Rigshospitalets forskningspulje
FX The study is initiated by the coordinating responsible investigator.
   There has been granted a Ph.D. scholarship from Rigshospitalets
   forskningspulje (3 years) for conduction of this study (and 2 other
   STS-related projects), and the amount given in total is 2,040,000 DKK.
CR [Anonymous], 2018, ICMJE RECOMMENDATION
   [Anonymous], 2013, JAMA-J AM MED ASSOC, DOI DOI 10.1001/JAMA.2013.281053
   [Anonymous], 2021, ICMJE FORM DISCLOSUR
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NR 22
TC 2
Z9 2
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUN 18
PY 2022
VL 23
IS 1
AR 507
DI 10.1186/s13063-022-06468-6
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 2F0XI
UT WOS:000812640500005
PM 35717239
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dorth, D
   Königs, I
   Elrod, J
   Ghadban, T
   Reinshagen, K
   Boettcher, M
AF Dorth, Deborah
   Koenigs, Ingo
   Elrod, Julia
   Ghadban, Tarik
   Reinshagen, Konrad
   Boettcher, Michael
TI Combination of Side-Swing Flap With Negative-Pressure Wound Therapy Is
   Superior to Open Excision or Flap Alone in Children With Pilonidal
   Sinus-But at What Cost?
SO FRONTIERS IN PEDIATRICS
LA English
DT Article
DE pilonidal sinus; negative-pressure wound therapy; NPWT; open excision;
   side-swing flap
AB Background: Pilonidal sinus (PS) disease frequently occurs in adolescents and young adults, and in many cases involves wide excision or local flaps as treatment. These treatments are associated with a significant recurrence rate, a long healing time, and thus absence from school or work. The hybrid technique, which is a combination of side-swing plasty with negative-pressure wound therapy (NPWT) may improve these outcomes. The aim of the study was to compare the latter with other current methods.
   Methods: Children presenting with a pilonidal sinus to two referral centers for pediatric surgery from January 2017 till June 2019 and subsequent (1) slide-swing plasty, (2) open excision, or (3) slide-swing plasty in combination with NPWT were included in this retrospective study. Type of therapy, number of interventions, duration of hospitalization, complications, and recurrence rate were recorded. In addition, data was retrieved from the national diagnosis-related group for inpatient statistics, for all patients who underwent surgery for pilonidal sinus in 2015 and 2016.
   Results: In total, 85 children were included, with a mean age of 15 years and a near equal gender distribution (53% female). The minimum follow-up was 1 year. In 56% open resection was performed, while 18% underwent a slide-swing plasty and 26% a slide-swing plasty in combination with NPWT. While the hybrid technique was superior regarding recurrence rate in comparison to open excision (24 vs. 5%, p = 0.047), it had significantly longer hospital stay [17.41 (15.63) vs. 3.65 (1.68) days, p < 0.001] and number of interventions [4.14 (4.07) vs. 1.04 (0.29), p < 0.001].
   Conclusions: Management of PS disease using slide-swing plasty in combination with NPWT is an effective treatment and is associated with low recurrence rate and minimal morbidity. However, this type of treatment is accompanied by an elongated hospitalization time and more frequent interventions. A diligent case by case evaluation and thorough patient counseling is thus necessary when choosing the right technique for the treatment of PS disease.
C1 [Dorth, Deborah; Koenigs, Ingo; Elrod, Julia; Reinshagen, Konrad; Boettcher, Michael] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Surg, Hamburg, Germany.
   [Ghadban, Tarik] Univ Med Ctr Hamburg Eppendorf, Dept Gen Visceral & Thorac Surg, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Boettcher, M (通讯作者)，Univ Med Ctr Hamburg Eppendorf, Dept Pediat Surg, Hamburg, Germany.
EM m.boettcher@uke.de
RI Boettcher, Michael/P-6128-2018
OI Boettcher, Michael/0000-0003-4972-9866
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NR 23
TC 8
Z9 12
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD APR 14
PY 2021
VL 9
AR 595684
DI 10.3389/fped.2021.595684
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA RT8HL
UT WOS:000644696800001
PM 33937143
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Montgomery, A
   van Eeden, L
   Boo, M
   Maul, K
   de Silva, K
   Klasan, A
   Sedgwick, PM
   Eva, L
   Bergzoll, C
AF Montgomery, Alison
   van Eeden, Lulu
   Boo, Marilyn
   Maul, Kayleigh
   de Silva, Karl
   Klasan, Antonio
   Sedgwick, Philip Martin
   Eva, Lois
   Bergzoll, Cecile
TI Does Closed Incision Negative Pressure Wound Therapy Reduce Surgical
   Site Infection in Endometrial Carcinoma Patients Undergoing Laparotomy?
   A Multicentre Retrospective Cohort Study
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE surgical site infection; negative pressure wound therapy; endometrial
   carcinoma
ID SURGERY; VACUUM
AB Background: Endometrial cancer is the most common gynaecological cancer and has a strong association with obesity. Surgical site infection (SSI) carries high morbidity and is more frequent in obese patients. Closed incision negative pressure wound therapy (ciNPWT) has been proposed to reduce wound morbidity but is more expensive than standard dressings whilst the evidence has been very heterogenous. There is limited evidence to justify this expensive dressing as related to its effectiveness in gynaecological oncology patients. ciNPWT was introduced in New Zealand in 2017 based on the available evidence from studies on SSI in the obstetric population. The aim of this study is to investigate the rate of SSI in patients with endometrial carcinoma undergoing laparotomy using standard surgical dressings compared to ciNPWT. Methods: We performed a retrospective analysis of 170 patients who underwent a laparotomy for endometrial carcinoma between 2018 and 2019 across three hospitals in New Zealand after the introduction of ciNPWT. Dressings were applied according to individual surgeons' preferences. Standard dressings and ciNPWT were compared in the occurrence of SSI, wound dehiscence, readmission and return to theatre rates using logistic regression in order to account for potential confounding due to the patient demographics and oncologic and surgical characteristics. Results: There were 129 patients in the standard dressing group and 41 patients in the ciNPWT group. The mean age was 60.4 years (range 25-86). The mean body mass index (BMI) was 38.2 kg/m2 (range 20-69 kg/m2). The percentage of patients who experienced a SSI was higher in the ciNPWT group (34.2% vs. 20.9%; p = 0.159). There was no significant difference between the dressing groups in the occurrence of superficial SSI rate, return to theatre, or readmission. Wound dehiscence and deep/organ space SSI were however worse with ciNPWT (adjusted odds ratio (aOR) 4.09 and aOR 7.19, respectively). Conclusions: This study demonstrated no evidence for the benefit of ciNPWT, and higher rates of deep/organ space SSI. More randomised trials are needed to investigate whether gynaecological oncology patients may benefit from ciNPWT thus justifying the extra cost of this dressing.
C1 [Montgomery, Alison] St Michaels Hosp, Gynaecol Dept, Bristol BS2 8EG, Avon, England.
   [van Eeden, Lulu; de Silva, Karl] Middlemore Hosp, Obstet & Gynaecol Dept, Auckland 2025, New Zealand.
   [Boo, Marilyn] Westmead Hosp, Gynaecol Oncol Dept, Westmead, NSW 2145, Australia.
   [Maul, Kayleigh] Northshore Hosp, Obstet & Gynaecol Dept, Auckland 0620, New Zealand.
   [Klasan, Antonio] AUVA Hosp, Orthopaed Dept, A-8020 Graz, Austria.
   [Sedgwick, Philip Martin] St Georges Univ London, Inst Med & Biomed Educ, London SW17 0RE, England.
   [Eva, Lois; Bergzoll, Cecile] Auckland City Hosp, Gynaecol Oncol Dept, Auckland 1023, New Zealand.
C3 NSW Health; Westmead Hospital; University of Sydney; City St Georges,
   University of London; Auckland City Hospital
RP Montgomery, A (通讯作者)，St Michaels Hosp, Gynaecol Dept, Bristol BS2 8EG, Avon, England.
EM alison.montgomery3@nhs.net
RI Sedgwick, Philip/C-6997-2019; Klasan, Antonio/S-6201-2019; Sedgwick,
   Philip Martin/C-6997-2019
OI Sedgwick, Philip Martin/0000-0001-8859-2175; Eva,
   Lois/0000-0002-4239-0313
CR 3M+KCI, 2020, PREV INC MAN SYST
   Astagneau P, 2001, J HOSP INFECT, V48, P267, DOI 10.1053/jhin.2001.1003
   Bakkum-Gamez JN, 2013, GYNECOL ONCOL, V130, P100, DOI 10.1016/j.ygyno.2013.03.022
   Centers for Disease Control and Prevention, 2017, SURG SIT INF
   Chambers LM, 2020, AM J OBSTET GYNECOL, V223, DOI 10.1016/j.ajog.2020.05.011
   clinicaltrials, 2020, NEG PRESS WOUND THER
   /clinicaltrials, 2020, PROPH NEG PRESS WOUN
   Concin N, 2021, INT J GYNECOL CANCER, V31, P12, DOI 10.1136/ijgc-2020-002230
   Di Donato V, 2021, GYNECOL ONCOL, V161, P11, DOI 10.1016/j.ygyno.2020.12.030
   Dorafshar AH, 2012, ANN PLAS SURG, V69, P79, DOI 10.1097/SAP.0b013e318221286c
   Galaal K, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006655.pub3
   Giannini A, 2020, INT J GYNECOL OBSTET, V148, P174, DOI 10.1002/ijgo.13020
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   Yin L, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.19871
NR 31
TC 2
Z9 2
U1 1
U2 3
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0390-6663
EI 2709-0094
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PD MAY
PY 2023
VL 50
IS 5
AR 102
DI 10.31083/j.ceog5005102
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA J6HV4
UT WOS:001010613500013
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sweere, V
   Sliepen, J
   Haidari, S
   Depypere, M
   Mertens, M
   IJpma, F
   Metsemakers, WJ
   Govaert, G
AF Sweere, Vera
   Sliepen, Jonathan
   Haidari, Susan
   Depypere, Melissa
   Mertens, Maarten
   IJpma, Frank
   Metsemakers, Willem-Jan
   Govaert, Geertje
TI Use of negative pressure wound therapy in patients with fracture-related
   infection more than doubles the risk of recurrence
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Fracture-related infection; Osteomyelitis; Infection; Fracture; Bone
   infection; Wound; Negative pressure wound therapy; Complications;
   Re-infection; Recurrence of infection; Orthoplastic Surgery
ID COMPLICATIONS; MANAGEMENT
AB Purpose: Fracture-related infection (FRI) is one of the most serious complications in orthopedic trauma surgery. Despite its widespread use, the role of Negative Pressure Wound Therapy (NPWT) remains con-troversial in the management pathway of FRI. The aim of this study was to assess the relationship be-tween the application of NPWT and its duration and recurrence of infection in operatively treated FRI patients.Patients and Methods: This is a retrospective cohort study based on the FRI database of three level 1 Trauma Centres. Included patients had to be at least 16 years of age and surgically treated for FRI be-tween January 1st 2015 and September 1st 2020. Patients were subdivided in either the NPWT group, when NPWT was applied as part of the FRI treatment, or in the control group, when no NPWT had been applied. To limit confounding, patients were excluded if they (also) underwent NPWT prior to the diag-nosis of FRI. The relation between the duration of NPWT during FRI treatment and the recurrence rate of infection was analyzed using a multivariable logistic regression model.Results: A total of 263 patients were included, 99 in the NPWT group and 164 in the control group. The median duration of NPWT was 18.0 (IQR 15.8) days. In the NPWT group, 28 patients (28.3%) developed a recurrent FRI. In the control group, 19 patients (11.6%) had a recurrent FRI (p = 0.001, 95% CI [0.174 - 0.635]). In the NPWT group there were no significant differences in baseline characteristics between the recurrence and non-recurrence group. The duration of NPWT was associated with a higher risk of recurrence of infection (p = 0.013, OR 1.036, 95% CI [1.008 - 1.066]).Conclusion: Delayed wound closure with the application of NPWT increased the risk of recurrence of infection in patients with soft tissue defects after FRI treatment. Therefore, it is advised to consider NPWT only as a short-term (e.g. few days) necessity to bridge the period until definitive wound closure can be established. (c) 2022 The Authors. Published by Elsevier Ltd.
C1 [Sweere, Vera; Haidari, Susan; Govaert, Geertje] Univ Med Ctr Utrecht, Dept Trauma Surg, Utrecht, Netherlands.
   [Sliepen, Jonathan; IJpma, Frank] Univ Med Ctr Groningen, Dept Trauma Surg, Groningen, Netherlands.
   [Depypere, Melissa] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium.
   [Mertens, Maarten; Metsemakers, Willem-Jan] Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
   [Metsemakers, Willem-Jan] Univ Leuven, KU Leuven, Dept Dev & Regenerat, Leuven, Belgium.
   [Govaert, Geertje] Univ Med Ctr Utrecht UMCU, Dept Trauma Surg, POB 85500,Room G04 228, NL-3508GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; University of
   Groningen; KU Leuven; University Hospital Leuven; KU Leuven; University
   Hospital Leuven; KU Leuven
RP Govaert, G (通讯作者)，Univ Med Ctr Utrecht UMCU, Dept Trauma Surg, POB 85500,Room G04 228, NL-3508GA Utrecht, Netherlands.
EM g.a.m.govaert@umcutrecht.nl
RI Metsemakers, Willem-Jan/F-8647-2016; IJpma, Frank/AAH-6350-2019;
   Sliepen, Jonathan/JOZ-3183-2023; depypere, melissa/AAA-7578-2021
OI Metsemakers, Willem-Jan/0000-0002-4114-9093; IJpma,
   Frank/0000-0002-9420-2732; Mertens, Maarten/0000-0003-1256-5183;
   Sliepen, Jonathan/0000-0003-0176-112X; Haidari,
   Susan/0000-0003-0425-7543; 
CR [Anonymous], 2014, Infections of the Musculoskeletal System. Basic Principles, Prevention, Diagnosis and Treatment
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NR 29
TC 10
Z9 12
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2022
VL 53
IS 12
BP 3938
EP 3944
DI 10.1016/j.injury.2022.10.014
EA NOV 2022
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA E4MA8
UT WOS:000975287900013
PM 36424686
OA Green Submitted, Green Accepted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Lee, JY
   Jung, H
   Kwon, H
   Jung, SN
AF Lee, Jun Yong
   Jung, Hyunwook
   Kwon, Ho
   Jung, Sung-No
TI Extended negative pressure wound therapy-assisted dermatotraction for
   the closure of large open fasciotomy wounds in necrotizing fasciitis
   patients
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Article
DE Necrotizing fasciitis; Negative pressure wound therapy; Dermatotraction;
   Fournier's gangrene; Fasciotomy
ID SHOELACE TECHNIQUE; MANAGEMENT; DIAGNOSIS; LIMB
AB Background: Necrotizing fasciitis (NF) is a rapid progressive infection of the subcutaneous tissue or fascia and may result in large open wounds. The surgical options to cover these wounds are often limited by the patient condition and result in suboptimal functional and cosmetic wound coverage. Dermatotraction can restore the function and appearance of the fasciotomy wound and is less invasive in patients with comorbidities. However, dermatotraction for scarred, stiff NF fasciotomy wounds is often ineffective, resulting in skin necrosis. The authors use extended negative pressure wound therapy (NPWT) as an assist in dermatotraction to close open NF fasciotomy wounds. The authors present the clinical results, followed by a discussion of the clinical basis of extended NPWT-assisted dermatotraction.
   Methods: A retrospective case series of eight patients with NF who underwent open fasciotomy was approved for the study. After serial wound preparation, dermatotraction was applied in a shoelace manner using elastic vessel loops. Next, the extended NPWT was applied over the wound. The sponge was three times wider than the wound width, and the transparent covering drape almost encircled the anatomical wound area. The negative pressure of the NPWT was set at a continuous 100 mmHg by suction barometer. The clinical outcome was assessed based on wound area reduction after treatment and by the achievement of direct wound closure.
   Results: After the first set of extended NPWT-assisted dermatotraction procedures, the mean wound area was significantly decreased (658.12 cm(2) to 29.37 cm(2); p = 0.002), as five out of eight patients achieved direct wound closure. One patient with a chest wall defect underwent latissimus dorsi musculocutaneous flap coverage, with primary closure of the donor site. Two Fournier's gangrene patients underwent multiple sets of treatment and finally achieved secondary wound closure with skin grafts. The patients were followed up for 18.3 months on average and showed satisfactory results without wound recurrence.
   Conclusions: Extended NPWT-assisted dermatotraction advances scarred, stiff fasciotomy wound margins synergistically in NF and allows direct closure of the wound without complications. This method can be another good treatment option for the NF patient with large open wounds whose general condition is unsuitable for extensive reconstructive surgery.
C1 [Lee, Jun Yong] Catholic Univ Korea, Incheon St Marys Hosp, Dept Plast & Reconstruct Surg, Inchon 403720, South Korea.
   [Jung, Hyunwook; Kwon, Ho; Jung, Sung-No] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Plast & Reconstruct Surg, Uijeongbu Si 480717, Gyeonggi Do, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Jung, SN (通讯作者)，Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Plast & Reconstruct Surg, 271 Cheonbo Ro, Uijeongbu Si 480717, Gyeonggi Do, South Korea.
EM jsn7190@catholic.ac.kr
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NR 28
TC 44
Z9 53
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD APR 15
PY 2014
VL 9
AR 29
DI 10.1186/1749-7922-9-29
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AF6DR
UT WOS:000334805100001
PM 24731449
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lygrisse, KA
   Teo, G
   Singh, V
   Muthusamy, N
   Schwarzkopf, R
   William, L
AF Lygrisse, Katherine A.
   Teo, Greg
   Singh, Vivek
   Muthusamy, Nishanth
   Schwarzkopf, Ran
   William, Long
TI Comparison of silver-embedded occlusive dressings and negative pressure
   wound therapy following total joint arthroplasty in high BMI patients: a
   randomized controlled trial
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Article
DE Obesity; Wound dressing; Total joint arthroplasty; Negative pressure
   wound therapy; Wound complications; Prosthetic joint infection
ID SURGICAL SITE COMPLICATIONS; TOTAL KNEE ARTHROPLASTY; HIP;
   OSTEOARTHRITIS; INFECTION; RISK; SURGERY; AQUACEL; COST
AB Introduction High body mass index (BMI) and wound drainage following total joint arthroplasty (TJA) can lead to wound healing complications and periprosthetic joint infection. Silver-embedded occlusive dressings and negative pressure wound therapy (NPWT) have been shown to reduce these complications. The purpose of this prospective trial was to compare the effect of silver-embedded dressings and NPWT on wound complications in patients with BMI >= 35 m/kg2 undergoing TJA. Methods We conducted a randomized control trial of patients who had a BMI > 35 m/kg(2) and were undergoing primary TJA between October 2017 and February 2020. Patients who underwent revision surgery, or those with an active infection, previous scar, history of wound healing complications, post-traumatic degenerative joint disease with hardware, or inflammatory arthritis were excluded. Patients were randomized to receive either a silver-embedded occlusive dressing (control) or NPWT. Frequency distributions, means, and standard deviations were used to describe patient demographics, postoperative complications, 90-day readmissions, and reoperations. T-test and chi-squared tests were used to test for significant differences between continuous and categorical variables, respectively. Results Two hundred-thirty patients with 3-month follow-up were included. One-hundred-fifteen patients received the control and 115 patients received NPWT. There were six patients (5.2%) in the control group with wound complications (drainage: n = 5, non-healing wound: n = 1) and two patients (1.7%) in the NPWT with complications (drainage: n = 2). There were no 90-day readmissions in the control group versus two (1.8%) 90-day readmissions in the NPWT group. Finally, three patients (2.6%) in the control group underwent reoperations (irrigation and debridement [I&D], I&D with modular implant exchange, and implant revision), while none in the NPWT group had undergone reoperation. The two groups showed insignificant differences in wound complications (p = 0.28), 90-day readmissions (p = 0.50), and reoperations (p = 0.25). Conclusion Patients with BMI >= 35 m/kg2 undergoing TJA have no statistical difference in early wound complications, readmissions, or reoperations when treated with either silver-embedded dressings or NPWT.
C1 [Lygrisse, Katherine A.] Zucker Sch Med Hofstra Northwell, Huntington Hosp, Dept Orthoped Surg, 270 Pk Ave, Huntington, NY 11743 USA.
   [Teo, Greg; William, Long] Hosp Special Surg, Dept Orthoped Surg, 541 East 71st St,7th Fl, New York, NY 10021 USA.
   [Singh, Vivek; Muthusamy, Nishanth; Schwarzkopf, Ran] NYU Langone Hlth, Dept Orthoped Surg, 301 East 17th St,15th Fl Suite 1518, New York, NY 10003 USA.
   [Muthusamy, Nishanth] NYU Langone Hlth, Dept Orthoped Surg, Div Adult Reconstruct Surg, 301 East 17th St, New York, NY 10003 USA.
C3 Northwell Health; NYU Langone Medical Center; NYU Langone Medical Center
RP Muthusamy, N (通讯作者)，NYU Langone Hlth, Dept Orthoped Surg, 301 East 17th St,15th Fl Suite 1518, New York, NY 10003 USA.; Muthusamy, N (通讯作者)，NYU Langone Hlth, Dept Orthoped Surg, Div Adult Reconstruct Surg, 301 East 17th St, New York, NY 10003 USA.
EM nmuthusamy13@gmail.com
OI Muthusamy, Nishanth/0000-0003-1227-7093
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NR 29
TC 7
Z9 7
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD JUN
PY 2023
VL 143
IS 6
BP 2989
EP 2995
DI 10.1007/s00402-022-04530-1
EA JUL 2022
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA G9CW0
UT WOS:000819896800002
PM 35779102
DA 2026-07-24
ER

PT J
AU Hofmann, AT
   May, C
   Glaser, K
   Fortelny, RH
AF Hofmann, Anna Theresa
   May, Christopher
   Glaser, Karl
   Fortelny, Rene H.
TI Delayed Closure of Open Abdomen in Septic Patients Treated With Negative
   Pressure Vacuum Therapy and Dynamic Sutures: A 10-Years Follow-Up on
   Long-Term Complications
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; negative pressure wound therapy; delayed fascial closure;
   dynamic fascial suture; incisional hernia
ID ASSISTED WOUND CLOSURE; FASCIAL CLOSURE; HERNIA RATE; MANAGEMENT
AB Introduction: Patients with open abdomen after surgical interventions associated with the complication of secondary peritonitis are successfully treated with negative pressure wound therapy. The use of dynamic fascial sutures reduces fascial lateralization and increases successful delayed fascial closure after open abdomen treatment.
   Methods: In 2017 we published the follow-up results of 38 survivors out of 87 open abdomen patients treated with negative pressure wound therapy and dynamic fascial sutures between 2007 and 2012. In our current study we present the 10-years follow-up results regarding long-term complications with the focus on incisional hernias and pain. Since 2017 seven more patients have died, hence 31 patients were included in the current study. The patients were asked to answer questions about specific long-term complications of OA treatment including pain, the presence of incisional hernias and subsequent surgical interventions. Demographic data and data regarding fascial closure after open abdomen treatment were collected. All results were analyzed quantitatively. The follow-up period was 8-13 years.
   Results: The median age was 69 (30-90) years, and 15 (48.4%) were females. Twenty-four patients (77.4%) responded to the questionnaire: Three patients (12.5%) suffered from pain in the original operating field, all three at rest but not during exercise. None of the patients required analgesic treatment. Eleven patients (45.8%) were found to have incisional hernias. Five out of 11 hernias (45.5%) were treated by surgery and did not declare any pain in the operating field. Among the patients with incisional hernias lower MPI (Mannheimer Peritonitis Index) at the time of primary surgery but more reoperations and treatment days were found. The technique of fascial closure was heterogenic and no differences in the occurrence of incisional hernia could be detected.
   Conclusion: The incidence of incisional hernias after open abdomen treatment is still high, but are associated with little pain in the original operating field. Further studies are required to investigate methods for fascial closure techniques after OA treatment.
C1 [Hofmann, Anna Theresa; May, Christopher; Glaser, Karl; Fortelny, Rene H.] Klin Ottakring, Dept Gen Visceral & Oncol Surg, Vienna, Austria.
   [Fortelny, Rene H.] Sigmund Freud Private Univ, Med Fac, Vienna, Austria.
RP Hofmann, AT (通讯作者)，Klin Ottakring, Dept Gen Visceral & Oncol Surg, Vienna, Austria.
EM anna.hofmann@gesundheitsverbund.at
RI Fortelny, René/AAD-5922-2021
CR Bjarnason T, 2013, WORLD J SURG, V37, P2031, DOI 10.1007/s00268-013-2082-x
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NR 25
TC 4
Z9 5
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 15
PY 2021
VL 7
AR 611905
DI 10.3389/fsurg.2020.611905
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PZ3SF
UT WOS:000612658300001
PM 33521047
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sun, HJ
   Si, SW
   Ma, YM
   Liu, XK
   Geng, HF
   Liang, J
AF Sun, Hao-Jie
   Si, Shan-Wen
   Ma, Ya-Mei
   Liu, Xue-Kui
   Geng, Hou-Fa
   Liang, Jun
TI Role of nuclear factor erythroid 2-related factor 2 in negative pressure
   wound therapy for diabetic foot ulcers
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcers; Nuclear factor
   erythroid 2-related factor 2; Kelch-like epichlorohydrin-associated
   protein 1; Healing
ID NRF2; ANGIOGENESIS; NPWT
AB BACKGROUND Negative pressure wound therapy (NPWT) is a potential treatment for diabetic foot ulcers (DFUs), although the mechanisms underlying its effectiveness remain unclear. This study posits that NPWT may improve wound healing by promoting angiogenesis and activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like epichlorohydrin-associated protein 1 (Keap1) signaling pathway, which is crucial for the body's defense against oxidative stress. The hypothesis indicates that enhancing antioxidant defenses through NPWT may positively affect the healing process. There are still limited data on the roles of Nrf2, its downstream signaling molecules, and angiogenesis markers in patients undergoing NPWT. AIM To study the mechanism of NPWT in DFUs. METHODS This study included a total of 40 hospitalized patients with DFUs from Xuzhou Central Hospital, who were divided into Control group (n = 21) and NPWT group (n = 19). The levels of Nrf2 and Keap1 were analyzed in the granulation tissue 7 days after treatment. The wound condition, erythrocyte sedimentation rate (ESR), procalcitonin (PCT), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), cluster of differentiation 31 (CD31), and levels of oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (T-AOC)] were analyzed before and 7 days after treatment by the Mann-Whitney U test. RESULTS The NPWT group demonstrated significant improvements in wound healing compared to the control group after 7 days of treatment. The levels of ESR, PCT, IL-6, and TNF-alpha were significantly reduced in the NPWT group compared to the control group (P < 0.05), while the levels of CD31, VEGF, and b-FGF showed significant increases (P < 0.05). The NPWT group exhibited notable elevations in the levels of Nrf2 and its downstream targets (SOD, CAT, and T-AOC), accompanied by decreases in the levels of Keap1 and MDA (P < 0.05). CONCLUSION NPWT may contribute to the healing of DFUs by potentially reducing levels of oxidative stress. Its effects could possibly be enhanced through the action of Nrf2.
C1 [Sun, Hao-Jie; Liu, Xue-Kui; Geng, Hou-Fa; Liang, Jun] Xuzhou Cent Hosp, Dept Endocrinol, 199 Jiefang South Rd, Xuzhou 221009, Jiangsu, Peoples R China.
   [Si, Shan-Wen] Anhui Med Univ, Fuyang Hosp, Dept Sci Res, Fuyang 236112, Anhui, Peoples R China.
   [Ma, Ya-Mei] Anhui Med Univ, Fuyang Hosp, Electrocardiogram Room, Fuyang 236112, Anhui, Peoples R China.
C3 Southeast University - China; Anhui Medical University; Anhui Medical
   University
RP Liang, J (通讯作者)，Xuzhou Cent Hosp, Dept Endocrinol, 199 Jiefang South Rd, Xuzhou 221009, Jiangsu, Peoples R China.
EM mwlj521@njmu.edu.cn
RI Sun, Haojie/LRT-6797-2024; Houfa, Geng/ABI-6352-2020
CR Ayd MS, 2024, J ORTHOP SCI, V29, P1060, DOI 10.1016/j.jos.2023.07.015
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NR 35
TC 0
Z9 0
U1 1
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD MAY 15
PY 2025
VL 16
IS 5
AR 104350
DI 10.4239/wjd.v16.i5.104350
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2WQ5R
UT WOS:001493085500012
PM 40487630
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Biancari, F
   Santoro, G
   Provenzano, F
   Savarese, L
   Iorio, F
   Giordano, S
   Zebele, C
   Speziale, G
AF Biancari, Fausto
   Santoro, Grazia
   Provenzano, Federica
   Savarese, Leonardo
   Iorio, Francesco
   Giordano, Salvatore
   Zebele, Carlo
   Speziale, Giuseppe
TI Negative-Pressure Wound Therapy for Prevention of Sternal Wound
   Infection after Adult Cardiac Surgery: Systematic Review and
   Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE sternal wound infection; surgical site infection; negative-pressure
   wound therapy; pico; prevena; avelle; vivanotec
ID INCISION MANAGEMENT; RISK; COST
AB The results of current studies are not conclusive on the efficacy of incisional negative-pressure wound therapy (NPWT) for the prevention of sternal wound infection (SWI) after adult cardiac surgery. A systematic review of the literature was performed through PubMed, Scopus and Google to identify studies which investigated the efficacy of NPWT to prevent SWI after adult cardiac surgery. Available data were pooled using RevMan and Meta-analyst with random effect models. Out of 191 studies retrieved from the literature, ten fulfilled the inclusion criteria and were included in this analysis. The quality of these studies was judged fair for three of them and poor for seven studies. Only one study was powered to address the efficacy of NPWT for the prevention of postoperative SWI. Pooled analysis of these studies showed that NPWT was associated with lower risk of any SWI (4.5% vs. 9.0%, RR 0.54, 95% CI 0.34-0.84, I-2 48%), superficial SWI (3.8% vs. 4.4%, RR 0.63, 95% CI 0.29-1.36, I-2 65%), and deep SWI (1.8% vs. 4.7%, RR 0.46, 95% CI 0.26-0.74, I-2 0%), but such a difference was not statistically significant for superficial SWI. When only randomized and alternating allocated studies were included, NPWT was associated with a significantly lower risk of any SWI (3.3% vs. 16.5%, RR 0.22, 95% CI 0.08-0.62, I-2 0%), superficial SWI (2.6% vs. 12.4%, RR 0.21, 95% CI 0.06-0.69, I-2 0%), and deep SWI (1.2% vs. 4.8%, RR 0.17, 95% CI 0.03-0.95, I-2 0%). This pooled analysis showed that NPWT may prevent postoperative SWI after adult cardiac surgery. NPWT is expected to be particularly useful in patients at risk for surgical site infection and may significantly reduce the burden of resources needed to treat such a complication. However, the methodology of the available studies was judged as poor for most of them. Further studies are needed to obtain conclusive results on the potential benefits of this preventative strategy.
C1 [Biancari, Fausto; Santoro, Grazia; Provenzano, Federica; Savarese, Leonardo; Iorio, Francesco; Giordano, Salvatore; Zebele, Carlo] GVM Care & Res, Clin Montevergine, I-83013 Mercogliano, Italy.
   [Biancari, Fausto] Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland.
   [Speziale, Giuseppe] Anthea Hosp, GVM Care & Res, I-70124 Bari, Italy.
C3 University of Helsinki; Helsinki University Central Hospital
RP Biancari, F (通讯作者)，GVM Care & Res, Clin Montevergine, I-83013 Mercogliano, Italy.; Biancari, F (通讯作者)，Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland.
EM faustobiancari@yahoo.it; leonardosavarese@libero.it; federfarma@live.it;
   leonardosavarese@libero.it; aorticaortic@gmail.com;
   salvatoregiordano970@libero.it; carlo.zebele@gmail.com;
   gspeziale@gvmnet.it
RI Biancari, Fausto/A-1039-2008; Iorio, Francesco/JQI-8555-2023
OI Biancari, Fausto/0000-0001-5028-8186; 
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NR 24
TC 18
Z9 23
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 15
AR 4268
DI 10.3390/jcm11154268
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3R9BQ
UT WOS:000839200300001
PM 35893360
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, Y
   Xu, M
   Wang, Z
   Zhu, X
   Xu, J
AF Liu, Y.
   Xu, M.
   Wang, Z.
   Zhu, X.
   Xu, J.
TI 撤稿声明: RETRACTION: The Effect of Incisional Negative Pressure Wound
   Therapy on the Improvement of Postoperative Cosmetic Suture Wounds and
   Scar Hyperplasia
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 28 April 2023, in Wiley Online Library (), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
CR Liu YJ, 2023, INT WOUND J, V20, P3081, DOI 10.1111/iwj.14183
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2025
VL 22
IS 3
AR e70303
DI 10.1111/iwj.70303
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DA8BD
UT WOS:001679005300001
PM 40049706
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Morris, PD
   Allaway, MGR
   Wright, D
AF Morris, Paul David
   Allaway, Matthew George Roy
   Wright, Danette
TI How to do mesh-mediated fascial traction for delayed primary closure of
   the open abdomen
SO ANZ JOURNAL OF SURGERY
LA English
DT Editorial Material
ID ASSISTED WOUND CLOSURE; LATERAL ABDOMINAL-WALL; BOTULINUM-TOXIN-A;
   DAMAGE-CONTROL; MANAGEMENT; LAPAROSTOMY; THICKNESS
AB The open abdomen can be a life-saving resuscitative manoeuvre in patients with catastrophic abdominal pathologies, however, can lead to the need for delayed primary closure. The most recent guidelines released from the European Hernia Society and World Society for Emergency Surgery both suggest mesh-mediated fascial traction in conjunction with negative pressure wound therapy as the preferred method in this situation. We present a detailed 'how to do it' on this technique.
C1 [Morris, Paul David; Allaway, Matthew George Roy; Wright, Danette] Blacktown & Mt Druitt Hosp, Dept Gen Surg, Blacktown, NSW, Australia.
   [Morris, Paul David; Wright, Danette] Univ Sydney, Camperdown, NSW, Australia.
C3 NSW Health; Blacktown & Mount Druitt Hospital; University of Sydney
RP Morris, PD (通讯作者)，Blacktown & Mt Druitt Hosp, Dept Gen Surg, Blacktown, NSW, Australia.; Morris, PD (通讯作者)，Univ Sydney, Camperdown, NSW, Australia.
EM morris.pd@gmail.com
OI Wright, Danette/0000-0002-9480-9673; Allaway,
   Matthew/0000-0001-7794-5094
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
   Acosta S, 2017, ANAESTH INTENSIVE TH, V49, P139, DOI 10.5603/AIT.a2017.0023
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   Zielinski MD, 2016, J TRAUMA ACUTE CARE, V80, P237, DOI 10.1097/TA.0000000000000917
NR 25
TC 1
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD JUL
PY 2023
VL 93
IS 7-8
BP 1999
EP 2002
DI 10.1111/ans.18474
EA MAY 2023
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W7QQ5
UT WOS:000981243800001
PM 37128158
OA hybrid
DA 2026-07-24
ER

PT J
AU Xu, NL
   Mi, W
AF Xu, N. L.
   Mi, W.
TI 撤稿声明: Effects of Negative Pressure Wound Therapy on Wound Infection and
   Healing in Patients with Open Fracture Wounds: A Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 07 February 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
CR Xu NL, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14757
NR 1
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70453
DI 10.1111/iwj.70453
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DA8NB
UT WOS:001679036300001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Walther, A
   De Marco, G
   Vazquez, O
   Steiger, C
   Boudabbous, S
   Dayer, R
   Ceroni, D
AF Walther, Adrien
   De Marco, Giacomo
   Vazquez, Oscar
   Steiger, Christina
   Boudabbous, Sana
   Dayer, Romain
   Ceroni, Dimitri
TI Synchronous Multifocal Necrotizing Fasciitis in an Infant: A Case Report
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE Synchronous; multifocal; necrotizing fasciitis; pediatric; magnetic
   resonance imaging; surgery; <italic>Streptococcus pyogenes</italic>
ID LABORATORY RISK INDICATOR; SOFT-TISSUE INFECTIONS; LRINEC SCORE;
   CELLULITIS; MORTALITY; DIAGNOSIS; SECONDARY; SHOCK; SKIN
AB We report an exceptional form of a synchronous multifocal necrotizing fasciitis (NF) affecting a 16-month-old girl. A high clinical suspicion of NF was confirmed by her laboratory risk indicators for necrotizing fasciitis score and magnetic resonance imaging. Blood cultures were positive for Streptococcus pyogenes. Successful outcomes were achieved through antibiotic treatment and an isolated surgical exploration using negative-pressure wound therapy.
C1 [Walther, Adrien; Vazquez, Oscar; Steiger, Christina; Boudabbous, Sana; Dayer, Romain; Ceroni, Dimitri] Geneva Univ Hosp, Dept Women Child & Adolescent, Pediat Surg Serv, Pediat Orthoped Unit, CH-1211 Geneva, Switzerland.
   [Dayer, Romain] Geneva Univ Hosp, Radiol Dept, CH-1211 Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Ceroni, D (通讯作者)，Geneva Univ Hosp, Dept Woman Child & Adolescent, Pediat Surg Serv, Pediat Orthoped Unit, 6 Rue Willy Donze, CH-1206 Geneva, Switzerland.
EM giacomo.demarco@hug.ch; oscar.vazquez@hug.ch; christina.steiger@hug.ch;
   sana.boudabbous@hug.ch; romain.dayer@hug.ch; dimitri.ceroni@hug.ch
RI boudabbous, sana/AAM-9368-2020
OI Vazquez, Oscar/0000-0002-1325-8575
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   Yoon MA, 2019, EUR RADIOL, V29, P3414, DOI 10.1007/s00330-019-06103-0
NR 46
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD DEC
PY 2025
VL 44
IS 12
BP e459
EP e462
DI 10.1097/INF.0000000000004900
PG 4
WC Immunology; Infectious Diseases; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Pediatrics
GA 9VT1P
UT WOS:001616181700009
PM 40526874
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Stemkens, R
   Cobussen, M
   de Laat, E
   Hoefsloot, W
   van Crevel, R
   Aarnoutse, RE
   van Ingen, J
AF Stemkens, Ralf
   Cobussen, Maarten
   de laat, Erik
   Hoefsloot, Wouter
   van Crevel, Reinout
   Aarnoutse, Rob E.
   van Ingen, Jakko
TI Successful addition of topical antibiotic treatment after surgery in
   treatment-refractory nontuberculous mycobacterial skin and
   softtissueinfectionssoft tissue infections
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
DE nontuberculous mycobacteria; skin and soft tissue infections; topical
   antibiotic treatment
AB Treatment of skin and soft tissue infections with nontuberculous mycobacteria sometimes fails despite repeated debridements and long-term systemic antibiotic therapy. These treatment-refractory infections can cause significant morbidity and pose a treatment challenge. Following surgery, we treated three patients with negative pressure wound therapy with the instillation and dwell time of topical antibiotics, in addition to systemic antibiotic treatment. Treatment was successful and well tolerated, except for some local irritation.
C1 [Stemkens, Ralf; Aarnoutse, Rob E.] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pharm, Med Ctr, Nijmegen, Netherlands.
   [Cobussen, Maarten; van Crevel, Reinout] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Internal Med & Infect Dis, Med Ctr, Nijmegen, Netherlands.
   [de laat, Erik] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Plast Surg, Med Ctr, Nijmegen, Netherlands.
   [Hoefsloot, Wouter] Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pulm Dis, Radboud Univ, Nijmegen, Netherlands.
   [van Ingen, Jakko] Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen; Radboud University Nijmegen; Radboud University
   Nijmegen
RP Stemkens, R (通讯作者)，Radboud Univ Nijmegen, Res Inst Med Innovat, Dept Pharm, Med Ctr, Nijmegen, Netherlands.
EM ralf.stemkens@radboudumc.nl
RI van Crevel, reinout/A-6636-2010; Hoefsloot, W./L-4376-2015; Aarnoutse,
   R.E./L-4168-2015; van Ingen, Jakko/D-5526-2014; /P-8241-2015; Stemkens,
   Ralf/AAQ-3932-2020; , reinout/A-6636-2010
OI van Ingen, Jakko/0000-0002-0581-2003; Stemkens,
   Ralf/0009-0008-6912-4163; , reinout/0000-0002-6233-6410
CR Bricheux A, 2019, CLIN MICROBIOL INFEC, V25, DOI 10.1016/j.cmi.2018.11.020
   Daley CL, 2020, EUR RESPIR J, V56, DOI 10.1183/13993003.00535-2020
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   Fleischmann W, 1998, UNFALLCHIRURG, V101, P649, DOI 10.1007/s001130050318
   Freitas D, 2003, OPHTHALMOLOGY, V110, P276, DOI 10.1016/S0161-6420(02)01643-3
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Lange C, 2022, LANCET INFECT DIS, V22, pE178, DOI 10.1016/S1473-3099(21)00586-7
   Saillard J., 2018, ANNALES PHARMACEUTIQUES FRANCAISES, V76, P107, DOI [10.1016/j.pharma.2017.11.005, 10.1016/j.pharma.2017.11.005]
   Sornsuvit C, 2021, DOSE-RESPONSE, V19, DOI 10.1177/15593258211059325
   van Ingen J, 2018, EUR RESPIR J, V51, DOI 10.1183/13993003.00170-2018
   van Wijk F, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.01203-19
NR 11
TC 9
Z9 10
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD DEC
PY 2023
VL 67
IS 12
DI 10.1128/aac.00788-23
EA NOV 2023
PG 6
WC Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Pharmacology & Pharmacy
GA 6DF8D
UT WOS:001124422800002
PM 38014946
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Loeck, J
   von Lücken, HJ
   Kehrl, W
   Loske, G
AF Loeck, J.
   von Luecken, H. -J.
   Kehrl, W.
   Loske, G.
TI Endoscopic negative pressure therapy (ENPT) of apost-laryngectomy
   pharyngocutaneous fistula: firstreport of anew treatment method
SO HNO
LA English
DT Article; Proceedings Paper
CT 55th Inner Ear Biology Workshop
CY SEP 06-08, 2018
CL Berlin, GERMANY
DE Respiratory tract fistula; Cutaneous fistula; Wound closure techniques;
   Negative-pressure wound therapy; Drainage
AB In the current first report, it is shown how apost-laryngectomy pharyngocutaneous fistula was successfully closed by endoscopic negative pressure therapy (ENPT; also termed endoscopic vacuum therapy, EVT). The duration of negative pressure treatment was 14days. Up until now, ENPT has been used for treatment of transmural defects in the rectum and esophagus. The new endoscopic method can also be used in the ENT field for closure of pharyngocutaneous fistulas.
C1 [Loeck, J.; von Luecken, H. -J.; Kehrl, W.] Kath Marienkrankenhaus Hamburg gGmbh, Dept Otorhinolaryngol Head & Neck Surg, Hamburg, Germany.
   [Loske, G.] Kath Marienkrankenhaus Hamburg gGmbH, Dept Gen Visceral Thorac & Vasc Surg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital; St. Marien Hospital
RP Loske, G (通讯作者)，Kath Marienkrankenhaus Hamburg gGmbH, Dept Gen Visceral Thorac & Vasc Surg, Alfredstr 9, D-22087 Hamburg, Germany.
EM loske.chir@marienkrankenhaus.org
OI Loeck, Jonathan/0000-0002-7995-9550
CR Boscolo-Rizzo P, 2008, EUR ARCH OTO-RHINO-L, V265, P929, DOI 10.1007/s00405-007-0562-z
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Loske G, 2019, CHIRURG, V90, pS1, DOI 10.1007/s00104-018-0727-x
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Loske G, 2018, ENDOSC INT OPEN, V6, pE865, DOI 10.1055/a-0599-5886
   Reiter M, 2013, AM J OTOLARYNG, V34, P411, DOI 10.1016/j.amjoto.2013.03.001
   Sayles M, 2014, LARYNGOSCOPE, V124, P1150, DOI 10.1002/lary.24448
   Wallstabe I, 2012, ENDOSCOPY, V44, pE49, DOI 10.1055/s-0031-1291525
NR 8
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0017-6192
EI 1433-0458
J9 HNO
JI HNO
PD JUN
PY 2019
VL 67
SU 2
BP 77
EP 79
DI 10.1007/s00106-019-0653-3
PG 3
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA ID3WF
UT WOS:000471607100007
PM 31053941
DA 2026-07-24
ER

PT J
AU Hong, J
   Xie, L
   Fan, L
   Huang, H
AF Hong, J.
   Xie, L.
   Fan, L.
   Huang, H.
TI 撤稿声明: RETRACTION: The Wound Adjuncts Effect of Closed Incision Negative
   Pressure Wound Therapy on Stopping Groin Surgical Site Wound Infection
   in Arterial Surgery: A Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 28 March 2023, in Wiley Online Library (), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
CR Hong J, 2023, INT WOUND J, V20, P2726, DOI 10.1111/iwj.14146
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2025
VL 22
IS 2
AR e70225
DI 10.1111/iwj.70225
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DA7TU
UT WOS:001678986200001
PM 39934959
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Schimp, VL
   Worley, C
   Brunello, S
   Levenback, CC
   Wolf, JK
   Sun, CC
   Bodurka, DC
   Ramirez, PT
AF Schimp, VL
   Worley, C
   Brunello, S
   Levenback, CC
   Wolf, JK
   Sun, CC
   Bodurka, DC
   Ramirez, PT
TI Vacuum-assisted closure in the treatment of gynecologic oncology wound
   failures
SO GYNECOLOGIC ONCOLOGY
LA English
DT Article
DE vacuum-assisted closure; wound failure
AB Objective. Negative pressure wound vacuum therapy can expedite the healing of complex wound failures. Our aim was to evaluate the use of a vacuum-assisted closure (VAC) device to treat complex wound failures in gynecologic oncology patients.
   Methods. We retrospectively identified 27 patients with gynecologic malignancies in whom the device was used to treat complex wound failures from January 2001 to May 2002 at our institution. We analyzed operative data and information regarding the diagnosis and management of these complex wound failures and the length of time the device was used.
   Results. The procedures performed before wound VAC placement were total abdominal hysterectomy with bilateral salpingooopherectomy with or without tumor reductive surgery in 14 patients, vulvectomy with or without inguinal lymph node dissection in five patients, skin or myocutaneous grafting in three patients, parastomal hemiorrhaphy in two patients, retroperitoneal lymph node dissection in two patients, and incision and drainage of a gluteal abscess after radiation therapy in one patient. Four of the 27 patients had the VAC device placed at the time of a reoperation, while the remaining 23 patients had the VAC device placed postoperatively for wound failures. Wound breakdown occurred at a median of 9 days (range: 0-88 days) postoperatively. Overall, there was a 96% reduction (range: 0-100%) in the median size of wound defects from 330 to 14.0 cm(3) with use of the VAC device. The median number of days of VAC therapy was 32 days (range: 3-88 days). Twenty patients used this device as outpatients, and the charge per day was approximately US$150.00. One patient experienced bleeding, and 26 patients experienced no complications. The only complaint was pain during dressing changes (67% of patients). The mean follow-up was 52 days (range: 0-270 days). At the time of last contact, 26 (96%) of 27 patients had complete wound healing.
   Conclusions. VAC therapy is a novel treatment using controlled negative pressure to evacuate wound fluid, stimulate granulation tissue, and to decrease bacterial colonization of the wound. Our experience indicates that this is a safe method to treat complex wound failures in gynecologic oncology patients. (C) 2003 Published by Elsevier Inc.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Nursing & Wound, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Ost, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Continence Nursing, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson
   Cancer Center
RP Ramirez, PT (通讯作者)，Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, 1515 Holcombe Blvd,Unit 440, Houston, TX 77030 USA.
EM peramire@mdanderson.org
OI Bodurka, Diane/0000-0001-6703-7607
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta PA, 2002, OBSTET GYNECOL, V99, P497, DOI 10.1016/S0029-7844(01)01752-5
   *KIN CONC, 2002, VAC ASS CLOS REC GUI
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   MORROW PC, 1996, GYNECOLOGIC CANC SUR, P141
   Morykwas M, 1993, 25 ANN C WOUND OST C
   MORYKWAS MJ, 1997, ANN PLAST SURG, V38, P554
   RYAN T, 1983, PHYS FACTORS ANGIOGE, P182
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
NR 10
TC 51
Z9 62
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
EI 1095-6859
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD FEB
PY 2004
VL 92
IS 2
BP 586
EP 591
DI 10.1016/j.ygyno.2003.10.055
PG 6
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA 779DX
UT WOS:000189281100012
PM 14766251
DA 2026-07-24
ER

PT J
AU Avery, C
   Pereira, J
   Moody, A
   Whitworth, I
AF Avery, C
   Pereira, J
   Moody, A
   Whitworth, I
TI Clinical experience with the negative pressure wound dressing
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS
AB Between 1997 and 1999, more than 300 patients have been treated using negative pressure wound dressings. The technique has been used successfully to prepare various acute, chronic or infected wounds to accept a skin graft or flap, and to promote graft take at difficult donor sites. The advantages include rapid healing by secondary intention, reduced time to skin grafting, an increase in the rate of graft take and a reduction in donor site complications. The dressing can be applied quickly and easily and there have been no serious complications.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead, England.
RP Avery, C (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead, England.
RI /AAI-1364-2019; moody, alan/M-9258-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Johnson PA, 1998, BRIT J ORAL MAX SURG, V36, P141, DOI 10.1016/S0266-4356(98)90184-X
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 5
TC 19
Z9 30
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD AUG
PY 2000
VL 38
IS 4
BP 343
EP 345
DI 10.1054/bjom.1999.0453
PG 3
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 344BD
UT WOS:000088737000021
PM 10922165
DA 2026-07-24
ER

PT J
AU Sziklavari, Z
   Ried, M
   Hofmann, HS
AF Sziklavari, Z.
   Ried, M.
   Hofmann, H. -S.
TI Intrathoracic Vacuum-Assisted Closure in the Treatment of Pleural
   Empyema and Lung Abscess
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE vacuum-assisted closure; VAC; pleural empyema; lung abscess; Mini-VAC;
   Mini-VAC-Instill
ID OPEN-WINDOW THORACOSTOMY; PRESSURE WOUND THERAPY; POSTPNEUMONECTOMY
   EMPYEMA; MANAGEMENT
AB Background: Complex pleural empyema or lung abscesses are either characterised by long-standing treatment (including treatment failure) or by a bad general condition of the patient (multiple morbidity, sepsis). The operative rectification is often associated with increased morbidity and mortality rates in these cases. Traditionally, the therapeutic tendency for such patients was towards primary creation of a thoracic window including open wound treatment, but this was always also associated with a long sickness and restrictions in the quality of life. The intrathoracic vacuum treatment (VAC) offers here entirely new options in the treatment of complicated pleural empyema and lung abscesses.
   Method: We present an illustration of our own clinical experience associated with a selective literature research via Medline (keywords: VAC, vacuum-assisted closure, thoracic empyema).
   Results: After the initial successes of the extra-thoracic application of the VAC treatment, the procedure was also analysed for its intrathoracic/pleural use to treat pleural empyema and lung abscesses with and without bronchus stump insufficiency. Initially, the use of the intrathoracic VAC treatment was carried out via a thoracic window (with rib resection), later we developed a minimally invasive procedure (Mini-VAC) while relieving the osseous thorax. An additional intrapleural rinsing with antiseptics (Mini-VAC-Instill) is very practical in cases of proven germ populations. The benefits of the Mini-Vac/Mini-VAC-Instill are: immediate secretion suction with quick local cleaning, rapid germ eradication with a small risk of a fresh population, improvement of the expansion behaviour of the lung as well as short treatment times with quick reclosure of the thorax. In addition to many retrospective examinations, there has so far only been one cohort study in which the classic thoracic window was compared with the VAC treatment. The duration of the stomatic situation as well as the long-term survival in the VAC group were better here than those in the non-VAC group.
   Conclusion: The intrathoracic VAC treatment (Mini-Vac/Mini-VAC-Instill) is an innovative procedure that promotes wound cleaning and wound healing in complicated pleural empyema and lung abscesses. Due to the benefits of this procedure, including the improvement of the patient ' s comfort and the quality of life, the procedure has seen a rapid and broad clinical acceptance.
C1 [Sziklavari, Z.; Hofmann, H. -S.] Krankenhaus Barmherzige Bruder, Klin Thoraxchirurg, D-93049 Regensburg, Germany.
   [Ried, M.; Hofmann, H. -S.] Univ Klinikum Regensburg, Klin Thoraxchirurg, Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Krankenhaus Barmherzige Bruder, Klin Thoraxchirurg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Ried, Michael/AAC-4518-2022; Sziklavari, Zsolt/AGI-2440-2022
OI Ried, Michael/0000-0002-2365-4803; 
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NR 38
TC 8
Z9 9
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD JUN
PY 2015
VL 140
IS 3
BP 321
EP 327
DI 10.1055/s-0034-1383273
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CL5YC
UT WOS:000357040200024
PM 25906022
DA 2026-07-24
ER

PT J
AU Roberts, S
   Creamer, K
   Shoupe, B
   Flores, Y
   Robie, D
AF Roberts, S
   Creamer, K
   Shoupe, B
   Flores, Y
   Robie, D
TI Unique management of stage 4S neuroblastoma complicated by massive
   hepatomegaly: Case report and review of the literature
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Review
DE stage 4S neuroblastoma; abdominal wall expansion; negative-pressure
   dressing; diffuse alveolar hemorrhage
ID IV-S NEUROBLASTOMA; DIFFUSE ALVEOLAR HEMORRHAGE; BONE-MARROW
   TRANSPLANTATION; VACUUM-ASSISTED CLOSURE; NEURO-BLASTOMA; ABDOMINAL
   EXPANSION; WOUND CONTROL; THERAPY; CORTICOSTEROIDS; CRITERIA
AB Stage 4S neuroblastoma is an unusual malignancy that has an excellent prognosis, except in young infants. A 2-month-old with 4S neuroblastoma complicated by massive hepatomegaly, managed by abdominal decompression surgery and a negative-pressure dressing system is presented. Diffuse alveolar hemorrhage also developed, which was treated with high-dose corticosteroids.
C1 Tripler Army Med Ctr, Dept Pediat, Tripler, HI USA.
   Tripler Army Med Ctr, Dept Crit Care, Tripler, HI USA.
   Tripler Army Med Ctr, Dept Surg, Tripler, HI USA.
C3 United States Department of Defense; United States Army; Tripler Army
   Medical Center; United States Department of Defense; United States Army;
   Tripler Army Medical Center; United States Department of Defense; United
   States Army; Tripler Army Medical Center
RP Roberts, S (通讯作者)，Doernbecher Mem Hosp Children, 3181 SW Sam Jackson Pk Rd CDRCP, Portland, OR 97219 USA.
EM roherste@ohsu.edu
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NR 18
TC 12
Z9 13
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1077-4114
EI 1536-3678
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD FEB
PY 2002
VL 24
IS 2
BP 142
EP 144
DI 10.1097/00043426-200202000-00017
PG 3
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA 520YD
UT WOS:000173810600015
PM 11990702
DA 2026-07-24
ER

PT J
AU Mori, GA
   Tiernan, JP
AF Mori, George A.
   Tiernan, Jim P.
TI Management of Perineal Wounds Following Pelvic Surgery
SO CLINICS IN COLON AND RECTAL SURGERY
LA English
DT Article
DE perineal wound; abdominoperineal tesection; exenteration; vertical
   rectus abdominis myocutaneous; IGAP; gluteal flap
ID EXTRALEVATOR ABDOMINOPERINEAL EXCISION; VACUUM-ASSISTED CLOSURE;
   PREOPERATIVE RADIOTHERAPY; CROHNS-DISEASE; RECTAL-CANCER; RISK-FACTORS;
   ANTIMICROBIAL PROPHYLAXIS; RESECTION; RECONSTRUCTION; PROCTECTOMY
AB Despite advancements in understanding and technique, there remain significant challenges in the management of a complex perineal wound following pelvic surgery. Complications including wound sepsis, fistulation, persistent sinus, and herniation produce additional morbidity and health care costs. This article details the methods of optimizing patient and operative factors to mitigate this risk, alongside strategies to deal with sequelae of wound failure.
C1 [Mori, George A.; Tiernan, Jim P.] St James Univ Hosp, John Goligher Colorectal Unit, Leeds, W Yorkshire, England.
C3 Saint James's University Hospital
RP Tiernan, JP (通讯作者)，John Goligher Colorectal Unit, Leeds LS9 7TF, W Yorkshire, England.
EM j.tieman@nhs.net
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NR 81
TC 1
Z9 4
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1531-0043
EI 1530-9681
J9 CLIN COLON RECT SURG
JI Clin. Colon Rectal Surg.
PD MAY
PY 2022
VL 35
IS 03
BP 212
EP 220
DI 10.1055/s-0042-1742414
EA MAR 2022
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 3S5TD
UT WOS:000765510600001
PM 35966381
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Chang, SS
   Zhang, F
   Chen, W
   Zhou, J
   Nie, KY
   Deng, CL
   Wei, ZR
AF Chang, Shusen
   Zhang, Fang
   Chen, Wei
   Zhou, Jian
   Nie, Kaiyu
   Deng, Chengliang
   Wei, Zairong
TI Outcomes of integrated surgical wound treatment mode based on tibial
   transverse transport for diabetic foot wound
SO FRONTIERS IN SURGERY
LA English
DT Article
DE integrated surgical wound treatment; diabetic foot ulcer; tibial
   transverse transport; antibiotic bone cement; vacuum sealing drainage
ID CLASSIFICATION; AMPUTATION; INFECTION; ULCER
AB BackgroundDiabetic foot ulcer (DFU) is frequently difficult to heal and finally leads to amputation, resulting in high mortality rate in diabetic patients. To date, effective and optimal therapies are still lacking. This study aims to investigate the efficacy of integrated surgical wound treatment (ISWT) mode on diabetic foot wound. MethodsFrom January 2021 to December 2021, 13 diabetic foot patients with Wagner grade 3 to 4 were treated with ISWT mode, which combined TTT technique with debridement, induced membrane technique, vacuum sealing drainage (VSD) technique and skin grafting technique. The time of wound healing, the skin temperature at midpoint of dorsum of affected foot (T), visual analogue scale (VAS) score and ankle-brachial index (ABI) was measured before and after surgery. CTA examination of the lower extremity arteries was performed at the end of the cortex transport to evaluate the small arteriolar formation of the lower extremity. The complications occurred in each patient were recorded. Results13 patients with age ranging from 45 to 66 years were followed up for 3 to 13 months. All patients healed completely without amputation being performed, no serious complications were found except for one case of nail channel infection. The mean healing time was 25.8 +/- 7.8 days, with a range of 17 to 39 days. The mean time of carrying external fixation scaffolds and resuming walking was 71.8 +/- 10.0 and 30.8 +/- 9.1 days, with a range of 56 to 91 days and 18 to 45 days, respectively. The skin temperature at midpoint of dorsum of affected foot (T), VAS and ABI was all improved significantly at 3 months after surgery. Furthermore, CTA examination showed an increase in the number of lower extremity arteries and a thickening in the size of small arteriolar compared with those of pre-operative, and the collateral circulation of lower extremity was established and interweaved into a network. ConclusionIntegrated surgical treatment of diabetic foot wound can achieve satisfactory clinical results.
C1 [Chang, Shusen; Zhang, Fang; Chen, Wei; Zhou, Jian; Nie, Kaiyu; Deng, Chengliang; Wei, Zairong] Zunyi Med Univ, Dept Burn & Plast Surg, Affiliated Hosp, Zunyi, Peoples R China.
   [Chang, Shusen; Zhang, Fang; Chen, Wei; Zhou, Jian; Nie, Kaiyu; Deng, Chengliang; Wei, Zairong] Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University
RP Wei, ZR (通讯作者)，Zunyi Med Univ, Dept Burn & Plast Surg, Affiliated Hosp, Zunyi, Peoples R China.; Wei, ZR (通讯作者)，Zunyi Med Univ, Collaborat Innovat Ctr Tissue Damage Repair & Rege, Zunyi, Peoples R China.
EM zairongwei@163.com
RI Chang, Shusen/KRQ-3101-2024
FU Guizhou province, PR China [2020-5012, 2020-39, 2021-3]; Ministry
   Jointly Built Collaborative Innovation Center Project [2020-39, 2021-3]
FX This work was supported by the Wound Surgery Integrated Treatment
   Science and Technology Innovation Talent Team (2020-5012) of Guizhou
   province, PR China; Provincial and Ministry Jointly Built Collaborative
   Innovation Center Project (2020-39) of Guizhou province, PR China;
   Construction of Innovative Talent Platform Carrier for Precise Wound
   Repair (2021-3) of Guizhou province, PR China.
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NR 28
TC 11
Z9 20
U1 3
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 16
PY 2023
VL 9
AR 1051366
DI 10.3389/fsurg.2022.1051366
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8I3YC
UT WOS:000921659400001
PM 36726959
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhao, Y
   Zhao, Y
   Zhang, LQ
   Feng, GD
AF Zhao, Yong
   Zhao, Yang
   Zhang, Li-Qin
   Feng, Guo-Dong
TI Postoperative infection of the skull base surgical site due to
   suppurative parotitis: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Postoperative infection; Lateral skull base; Suppurative parotitis;
   Vacuum sealing drainage; Two-stage surgery; Case report
ID PHEOCHROMOCYTOMA; SURGERY
AB BACKGROUND Paraganglioma occurring at the lateral skull base is a rare tumor. Surgery is the primary treatment of benign paragangliomas. Postoperative infection of the surgical site at the lateral skull base is very dangerous and hard to manage. CASE SUMMARY A 30-year-old man with a 1-year history of left-side progressive hearing loss, tinnitus, facial palsy, and choking failed conventional treatment and is the focus of this case report. Imaging revealed a mass around the left jugular foramen that was approximately 47 mm x 38 mm x 34 mm in size and had eroded the bone of the vertebral and horizontal segments of the internal carotid artery. The tumor breached the meninges and occupied the cerebella pontine region. A two-stage surgery was designed for the resection of the mass. In the first-stage, the epidural portion of the mass was removed. The abdominal fat and the temporal muscle flap were transposed within the surgical site. The surgery was successful; however, 25 d after surgery, he developed suppurative parotitis, and the infection spread to the surgical site at the skull base. Broad-spectrum antibiotics were used, and debridement was deployed. After that, the wound was cleaned daily. Five months after the first-stage surgery, the wound was still unclosed, and there was intermittent purulent exudation within the surgical site. vacuum sealing drainage (VSD) was used, and the wound healed in a month. One year after the first surgery, the second-stage of the operation was performed to remove the intracranial portion of the tumor. Recurrence of the tumor was not detected after a 6-month follow-up. CONCLUSION After a lateral skull base surgery, suppurative parotitis can spread into the operative cavity leading to infection of the surgical site. VSD can help to effectively heal the infected wound. A two-stage surgical approach offers a safer option for removing the lateral skull base paraganglioma that involves the meninges.
C1 [Zhao, Yong; Zhao, Yang; Zhang, Li-Qin; Feng, Guo-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100730, Peoples R China.
   [Feng, Guo-Dong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Feng, GD (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
EM ok_surgeon@163.com
RI Feng, Guodong/PJS-4356-2026
CR Belczak SQ, 2008, REV I MED TROP, V50, P303, DOI 10.1590/S0036-46652008000500010
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NR 12
TC 0
Z9 1
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD MAY 26
PY 2022
VL 10
IS 15
BP 4991
EP 4997
DI 10.12998/wjcc.v10.i15.4991
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2E3MS
UT WOS:000812133700030
PM 35801038
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Wu, ZY
   Huang, HY
   Shi, YC
   Li, J
   Liao, SM
   Xu, SH
   Xian, JJ
   Cai, XF
   Zhang, PH
   Wu, ZY
AF Wu, Zeyong
   Huang, Haiyan
   Shi, Yucang
   Li, Jin
   Liao, Simu
   Xu, Shuhao
   Xian, Jiajie
   Cai, Xiaofen
   Zhang, Peihua
   Wu, Zhiyuan
TI Clinical study of matrix vascular component gel combined with vacuum
   sealing drainage technique in chronic wounds
SO BIOMEDICAL MATERIALS
LA English
DT Article
DE adipose extracellular matrix/stromal vascular fraction gel;
   adipose-derived stem cells; VSD; chronic wounds
ID EXTRACELLULAR-MATRIX; FRACTION GEL; STEM-CELL
AB This study investigates the efficacy of the combination of extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) and vacuum sealing drainage (VSD) on chronic wounds. From February 2021 to February 2022, 20 patients with chronic wounds were recruited and were divided into experimental and control groups, with 10 patients in each group. Following debridement, we applied various treatments to all cases for 2 weeks. Subsequently, we observed the changes in the wound area and calculated the rate of wound healing. Simultaneously, the wound margin tissues were collected for histological analysis, and the inflammatory cell infiltration within the wound was assessed using HE staining. Masson staining was used to observe the collagen deposition on the wound surface, and CD31 immunohistochemistry was used to count the number of microvessels to evaluate the angiogenesis (Clinical trial registration number: ChiCTR-INR-17 013 540). The therapeutic outcomes for all cases included in this study were favorable after a two-week treatment period, and the wound area was smaller than before. The experimental group exhibited a significantly higher rate of wound healing compared to the control group. As revealed by HE staining in the experimental group, there was a marked reduction in the infiltration of inflammatory cells in the dermis. Masson staining demonstrated that the deposition of collagen fibers in the experimental group was more than the control group. CD31 immunohistochemistry showed an increased number of new blood vessels in the experimental group compared to the control group. Additionally, ECM/SVF-gel extract significantly enhanced the fibroblast proliferation and migration in vitro. The application of ECM/SVF gel combined with VSD in chronic wounds can accelerate wound healing by reducing inflammatory reaction, increasing collagen fiber deposition, and promoting angiogenesis. Therefore, the combination of ECM/SVF gel and VSD can be used as a simple, safe, and effective therapeutic method for chronic wounds.
C1 [Wu, Zeyong; Huang, Haiyan; Shi, Yucang; Li, Jin; Liao, Simu; Xu, Shuhao; Xian, Jiajie; Cai, Xiaofen; Zhang, Peihua; Wu, Zhiyuan] Guangdong Med Univ, Affiliated Hosp, Plast Surg, Zhanjiang, Guangdong, Peoples R China.
C3 Guangdong Medical University
RP Zhang, PH; Wu, ZY (通讯作者)，Guangdong Med Univ, Affiliated Hosp, Plast Surg, Zhanjiang, Guangdong, Peoples R China.
EM zhangph@gdmu.edu.cn; 18820620888@163.com
RI Huang, Huanghaiyan/IQW-8615-2023; shi, yucang/LFV-3234-2024; wu,
   zeyong/GZM-7313-2022
FU Clinical Research Project of Affiliated Hospital of Guangdong Medical
   University [LCYJ2017A001]; National Stem Cell Clinical Research Record
   Project [MR-44-21-015762]; Zhanjiang Science and Technology Plan Project
   [2022A01189]; The 2021 Zhanjiang City Science and Technology Development
   Special Fund Competitive Allocation Project [2021A05081]; The 2014
   Zhanjiang City Financial Fund Science and Technology Special Competitive
   Allocation Project [2014C01022]
FX The study was supported by the Clinical Research Project of Affiliated
   Hospital of Guangdong Medical University [No. LCYJ2017A001], the
   National Stem Cell Clinical Research Record Project [No.
   MR-44-21-015762], Zhanjiang Science and Technology Plan Project [No.
   2022A01189], 2021 Zhanjiang City Science and Technology Development
   Special Fund Competitive Allocation Project [No. 2021A05081], and 2014
   Zhanjiang City Financial Fund Science and Technology Special Competitive
   Allocation Project [No. 2014C01022].
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   Yang ZB, 2021, AESTHET SURG J, V41, pNP1557, DOI 10.1093/asj/sjab033
   Yao Y, 2017, PLAST RECONSTR SURG, V139, P867, DOI 10.1097/PRS.0000000000003214
   Yin XL, 2023, INT WOUND J, V20, P1033, DOI 10.1111/iwj.13956
   Zhang Fl, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000018027
   Zhao YF, 2022, INT J BIOL MACROMOL, V207, P666, DOI 10.1016/j.ijbiomac.2022.02.114
   Zhu HD, 2019, JOVE-J VIS EXP, DOI 10.3791/58765
NR 41
TC 7
Z9 7
U1 0
U2 6
PU IOP Publishing Ltd
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-6041
EI 1748-605X
J9 BIOMED MATER
JI Biomed. Mater.
PD NOV 1
PY 2024
VL 19
IS 6
AR 065029
DI 10.1088/1748-605X/ad80ed
PG 13
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA J1P6A
UT WOS:001334862600001
PM 39332443
DA 2026-07-24
ER

PT J
AU Haghshenasskashani, A
   Rahnavardi, M
   Yan, TD
   McCaughan, BC
AF Haghshenasskashani, Alireza
   Rahnavardi, Mohammad
   Yan, Tristan D.
   McCaughan, Brian C.
TI Intrathoracic application of a vacuum-assisted closure device in
   managing pleural space infection after lung resection: is it an option?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Pleural space infection; Vacuum-assisted closure; Empyema; Lung
   resection
ID OPEN WINDOW THORACOSTOMY; POSTPNEUMONECTOMY EMPYEMA; MANAGEMENT; THERAPY
AB Empyema after lung resection is a challenging condition to manage and is associated with a high mortality. Intrathoracic application of a vacuum-assisted closure (VAC) device is recently introduced as an adjunct in the management of this condition. A best evidence topic was constructed to address whether this approach is effective in successful chest closure and reducing hospital stay. Twenty-three papers were found using the reported search, of which nine papers were identified that provided the best evidence to answer the question. All papers were retrospective and included a total of 69 patients treated with intrathoracic VAC. There was only one cohort study and the rest were either case series or case reports. In a cohort of 19 patients reported by Palmen et al. the average duration of an open window thoracostomy in a group of patients with VAC (n = 11) was 39 +/- 17 days and in those without VAC (n = 8) was 933 +/- 1422 days. Median length of VAC treatment was 22 days (range 6-66 days) in a series of 28 patients reported by Saadi et al. Some authors excluded patients with a bronchopleural fistula (BPF) from VAC treatment. However, Groetzner et al. have safely used VAC in patients with BPF after covering the bronchus stump with an intrathoracic muscle flap. The mediastinum and the bronchus can be covered using a polyvinyl-alcohol foam. Polyurethane foam is commonly used to fill the intrathoracic cavity up to the superficial wound. The suggested starting level of negative pressure is as low as -25 mmHg to -75 mmHg depending on the presence or absence of signs of mediastinal traction; this negative pressure can gradually be increased to -125 mmHg over time. The recommended interval between VAC changes is two to five days. Accumulated evidence in this article, although limited, suggests that VAC, as an adjunct to the standard treatment, can potentially alleviate the morbidity and decrease hospital stay in patients with empyema after lung resection. VAC can reduce inpatient length of treatment and can make the condition manageable in an outpatient setting. These results are yet to be proven by larger studies and clinical trials. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Haghshenasskashani, Alireza; Rahnavardi, Mohammad; Yan, Tristan D.; McCaughan, Brian C.] Univ Sydney, Royal Prince Alfred Hosp, Dept Cardiothorac Surg, Sydney, NSW 2006, Australia.
   [Haghshenasskashani, Alireza; Rahnavardi, Mohammad; Yan, Tristan D.; McCaughan, Brian C.] Baird Inst Appl Heart & Lung Surg Res, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; Royal Prince Alfred Hospital
RP Rahnavardi, M (通讯作者)，Univ Sydney, Royal Prince Alfred Hosp, Dept Cardiothorac Surg, Sydney, NSW 2006, Australia.
EM rahnavardi@gmail.com
OI Yan, Tristan/0000-0002-7473-1522
CR Al-Mufarrej F, 2010, SURG TODAY, V40, P711, DOI 10.1007/s00595-008-4096-9
   [Anonymous], 17 EUR C GEN THOR SU
   Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
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NR 16
TC 22
Z9 26
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD AUG
PY 2011
VL 13
IS 2
BP 168
EP 174
DI 10.1510/icvts.2011.267286
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 024YD
UT WOS:000310146800013
PM 21602420
OA Bronze
DA 2026-07-24
ER

PT J
AU Tocco, MP
   Costantino, A
   Ballardini, M
   D'Andrea, C
   Masala, M
   Merico, E
   Mosillo, L
   Sordini, P
AF Tocco, Maria Pia
   Costantino, Alberto
   Ballardini, Mitva
   D'Andrea, Claudio
   Masala, Marcello
   Merico, Eusebio
   Mosillo, Luigi
   Sordini, Paolo
TI Improved results of the vacuum assisted closure and Nitinol clips
   sternal closure after postoperative deep sternal wound infection
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Post-sternotomy mediastinitis; Vacuum
   assisted closure; Nitinol clips
ID POSTSTERNOTOMY MEDIASTINITIS; THERAPY
AB Objective: Postoperative deep sternal wound infection is a severe complication of cardiac surgery, with a high mortality rate and a high morbidity rate. The objective of this prospective study is to report our experience with the vacuum assisted closure (VAC) system for the management of deep wound infection. We also devised an innovative closure technique post VAC therapy using thermo reactive clips. The advantage of this technique is that the posterior face of the sternum does not have to be separated from the mediastinal structures thus minimising the risk of damage. Methods: From October 2006 to October 2008, we prospectively evaluated 21 patients affected by mediastinitis after sternotomy. Nineteen patients had sternotomy for coronary artery bypass grafting (CABG), one patient for aortic valve replacement (AVR) and another one for ascending aortic replacement (AAR). All patients were treated with the VAC system at the time of infection diagnosis. When the wound tissue appeared viable and the microbiological cultures were negative, the chest was closed using the most suitable procedure for the patient in question; nine patients were closed using pectoralis flaps, nine patients using Nitinol clips, one patient with a combined technique (use of Nitinol clips and muscle flap), one patient with a direct wound closure and another patient, who needed AAR with a homograft performed in another institution, was closed using sternal wires. Results: We had no mortality; wound heating was successfully achieved in all patients. In more than 50% of the patients, the VAC therapy allowed direct sternal resynthesis. The average duration of the vacuum therapy was 26 days (range 1437 days). Conclusions: VAC is a safe and effective option in the treatment of post-sternotomy mediastinitis, with excellent survival and immediate improvement of local wound conditions; furthermore, the use of Nitinol clips after VAC therapy demonstrated to be a safe and non-invasive option for sternal resynthesis. After VAC therapy, a reduction in number of muscular flaps used and an increase of direct sternal resynthesis were observed. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Tocco, Maria Pia; D'Andrea, Claudio; Mosillo, Luigi] S Filippo Neri Hosp, Thorac Surg Unit, Rome, Italy.
   [Costantino, Alberto; Merico, Eusebio; Sordini, Paolo] S Filippo Neri Hosp, Cardiac Surg Unit, Rome, Italy.
   [Ballardini, Mitva] S Filippo Neri Hosp, Microbiol Unit, Rome, Italy.
   [Masala, Marcello] S Filippo Neri Hosp, Dept Anaesthesia, Rome, Italy.
C3 San Filippo Neri Hospital; San Filippo Neri Hospital; San Filippo Neri
   Hospital; San Filippo Neri Hospital
RP Tocco, MP (通讯作者)，ACOS Filippo Neri, Thorac Surg Unit, Via G Martinotti 20, I-00135 Rome, Italy.
EM mptocco@yahoo.it
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Centofanti P, 2002, ANN THORAC SURG, V74, P943, DOI 10.1016/S0003-4975(02)03674-3
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NR 16
TC 26
Z9 27
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2009
VL 35
IS 5
BP 833
EP 838
DI 10.1016/j.ejcts.2008.12.036
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 446QX
UT WOS:000266137300018
PM 19216084
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhao, Y
   Zhang, M
   Zhang, CL
   Yan, HW
AF Zhao, Yi
   Zhang, Mi
   Zhang, Chuanlin
   Yan, Hongwei
TI Effect of local oxygen therapy combined with vacuum sealing drainage on
   the healing of stage IV sacrococcygeal pressure ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE local oxygen therapy; sacrococcygeal region; stage IV pressure ulcers;
   VSD; wound healing
ID WOUND THERAPY; IMPACT
AB The present study aimed to investigate the effect of local oxygen therapy combined with vacuum sealing drainage (VSD) on the healing of stage IV pressure ulcers sacrococcygeal. In this prospective study, we included a total of 98 patients with stage IV sacrococcygeal pressure ulcers in our hospital between February 2021 and June 2022. The patients enrolled were randomly and equally divided into two groups: the study group (undergoing local oxygen therapy combined with VSD treatment) and the control group (receiving conventional treatment). The wound healing time and hospital stay were compared between the two groups. Additionally, the wound area, tissue type, wound exudation and pain intensity were assessed before treatment, 10, 20, 30 and 40 days after treatment. The incidence of complications was also calculated. The study group demonstrated significantly shorter wound healing time and hospital stays compared to the control group (p < 0.05). Before treatment, there were no significant differences in terms of wound area, tissue type and wound exudation between the two groups (p > 0.05); after 10, 20, 30 and 40 days of treatment, however, evidently smaller wound areas, improved tissue types and reduced wound exudation were observed in the study group compared to the control group (p < 0.05). Furthermore, the study group exhibited increased microvascular count compared to the control group (p < 0.05). Before treatment, there was no significant difference in pain intensity between the two groups (p > 0.05), whereas markedly lower pain intensity was seen in the study group than in the control group after 10, 20, 30 and 40 days of treatment (p < 0.05). The incidence of complications did not significantly differ between the two groups after 40 days of treatment (p > 0.05). Local oxygen therapy combined with VSD was found to effectively accelerate the healing process of stage IV sacrococcygeal pressure ulcers, leading to shorter hospital stays and improved patient prognosis. This combined therapy shows promise for widespread application in clinical practice.
C1 [Zhao, Yi; Yan, Hongwei] Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, Shiyan, Peoples R China.
   [Zhang, Mi] Hubei Univ Med, Renmin Hosp, Dept Dermatol, Shiyan, Peoples R China.
   [Zhang, Chuanlin] Hubei Univ Med, Renmin Hosp, Dept Cardiol, Shiyan, Peoples R China.
   [Yan, Hongwei] Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, 39 Chaoyang Middle Rd, Shiyan 442000, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Medicine; Hubei University of Medicine
RP Yan, HW (通讯作者)，Hubei Univ Med, Renmin Hosp, Dept Burn & Plast Surg, 39 Chaoyang Middle Rd, Shiyan 442000, Hubei, Peoples R China.
EM 312698647@qq.com
RI yan, hongwei/PMF-7847-2026
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NR 28
TC 8
Z9 11
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2023
VL 20
IS 10
BP 4253
EP 4261
DI 10.1111/iwj.14327
EA AUG 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CH3W9
UT WOS:001048642700001
PM 37574848
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Attinger, C
   Cooper, P
AF Attinger, C
   Cooper, P
TI Soft tissue reconstruction for calcaneal fractures or osteomyelitis
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; FREE-FLAP; ULCERS; FOOT;
   MANAGEMENT; EXTREMITY; INFECTION; ARTERY
AB A systematic approach of the surgical management of calcaneal fractures can minimize the potential of soft tissue complications. Three important steps to reconstruction of soft tissue defects around the calcaneus include good blood supply, an infection-free wound, and the simplest soft tissue reconstructive option that covers the wound successfully. Soft tissue reconstruction ranges from delayed primary closure to the use of microsurgical free flaps. This article reviews the methods of soft tissue reconstruction for calcaneal fractures and osteomyelitis.
C1 Georgetown Univ Hosp, Georgetown Limb Ctr, Washington, DC 20007 USA.
C3 Georgetown University
RP Attinger, C (通讯作者)，Georgetown Univ Hosp, Georgetown Limb Ctr, 3800 Reservoir Rd, Washington, DC 20007 USA.
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NR 56
TC 50
Z9 62
U1 0
U2 6
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0030-5898
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD JAN
PY 2001
VL 32
IS 1
BP 135
EP +
DI 10.1016/S0030-5898(05)70199-1
PG 37
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 395MY
UT WOS:000166585200013
PM 11465125
DA 2026-07-24
ER

PT J
AU Greer, SE
   Grossi, EA
   Chin, D
   Longaker, MT
AF Greer, SE
   Grossi, EA
   Chin, D
   Longaker, MT
TI Subatmospheric pressure dressing for saphenous vein donor-site
   complications
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Newer endoscopic techniques have been successful at reducing saphenous vein donor-site wound complications, but not entirely eliminating them. Tissue necrosis with superimposed infection is typically treated with antibiotics and surgical debridement. Typically, primary reclosure is not possible and the open leg wound is allowed to slowly granulate with dressing changes until a skin graft can be performed. This report describes an alternative treatment using subatmospheric pressure dressing to promote granulation tissue and wound closure in saphenous vein donor-site wounds. (C) 2001 by The Society of Thoracic Surgeons.
C1 NYU, Sch Med, Inst Reconstruct Plast Surg, New York, NY 10010 USA.
   NYU, Sch Med, Div Cardiothorac Surg, New York, NY 10010 USA.
C3 New York University; New York University
RP Greer, SE (通讯作者)，300 E 34th St,9th Floor, New York, NY 10016 USA.
OI GROSSI, eugene/0000-0002-2066-7035; Longaker,
   Michael/0000-0003-1430-8914
CR Allen KB, 1998, ANN THORAC SURG, V66, P26, DOI 10.1016/S0003-4975(98)00392-0
   DELARIA GA, 1981, J THORAC CARDIOV SUR, V81, P403
   Greer SE, 2000, ANN PLAS SURG, V45, P332, DOI 10.1097/00000637-200045030-00019
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NR 8
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD MAR
PY 2001
VL 71
IS 3
BP 1038
EP 1040
DI 10.1016/S0003-4975(00)02431-0
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 410KM
UT WOS:000167439200077
PM 11269429
OA Bronze
DA 2026-07-24
ER

PT J
AU Shahein, AR
   Krasaelap, A
   Ng, K
   Bitton, S
   Khan, M
   Manfredi, MA
   Lerner, DG
AF Shahein, Abdul R.
   Krasaelap, Amornluck
   Ng, Kenneth
   Bitton, Samuel
   Khan, Muhammad
   Manfredi, Michael A.
   Lerner, Diana G.
TI Esophageal Dilation in Children: A State of the Art Review
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Review
DE esophageal dilation; esophageal narrowing; esophageal perforation;
   esophageal stenosis; esophageal stricture; mitomycin-C; triamcinolone
   injection
ID STEROID INJECTION THERAPY; MITOMYCIN-C APPLICATION; EOSINOPHILIC
   ESOPHAGITIS; ANASTOMOTIC STRICTURES; ENDOSCOPIC DILATION; BALLOON
   DILATION; ADVERSE EVENTS; MANAGEMENT; ATRESIA; PERFORATIONS
AB Esophageal dilations in children are performed by several pediatric and adult professionals. We aim to summarize improvements in safety and new technology used for the treatment of complex and refractory strictures, including triamcinolone injection, endoscopic electro-incisional therapy, topical mitomycin-C application, stent placement, functional lumen imaging probe assisted dilation, and endoscopic vacuum-assisted closure in the pediatric population.
C1 [Shahein, Abdul R.] Drexel Univ, St Christophers Hosp Children, Div Pediat Gastroenterol Hepatol & Nutr, Coll Med, Philadelphia, PA USA.
   [Krasaelap, Amornluck] Childrens Mercy Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Kansas City, MO USA.
   [Ng, Kenneth] Johns Hopkins Univ, Div Pediat Gastroenterol Hepatol & Nutr, Sch Med, Baltimore, MD USA.
   [Bitton, Samuel] Donald & Barbara Zucker Sch Med Hofstra Northwell, Div Pediat Gastroenterol Hepatol & Nutr, Hempstead, NY USA.
   [Khan, Muhammad] Childrens Natl Hosp, Div Pediat Gastroenterol Hepatol & Nutr, Washington, DC USA.
   [Manfredi, Michael A.] Univ Penn, Childrens Hosp Philadelphia, Div Pediat Gastroenterol Hepatol & Nutr, Philadelphia, PA USA.
   [Lerner, Diana G.] Med Coll Wisconsin, Div Pediat Gastroenterol Hepatol & Nutr, Milwaukee, WI USA.
   [Shahein, Abdul R.] Drexel Univ, St Christopher Hosp Children, Dept Pediat, Div Pediat Gastroenterol,Coll Med, 160 E Erie Ave, Philadelphia, PA 19134 USA.
C3 Drexel University; Children's Mercy Hospital; Johns Hopkins University;
   Northwell Health; Children's National Health System; University of
   Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia;
   Medical College of Wisconsin; Drexel University
RP Shahein, AR (通讯作者)，Drexel Univ, St Christopher Hosp Children, Dept Pediat, Div Pediat Gastroenterol,Coll Med, 160 E Erie Ave, Philadelphia, PA 19134 USA.
EM abdulrahman.shahein@mail.utoronto.ca
RI ; Bitton, Samuel/HJY-6351-2023; Krasaelap, Amornluck/AAA-2496-2021;
   Shahein, Abdul R/HLQ-0150-2023; Khan, Muhammad/GZK-7313-2022
OI Ng, Kenneth/0000-0002-1554-6204; Khan, Muhammad/0000-0002-2657-0904
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NR 56
TC 13
Z9 20
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD JAN
PY 2023
VL 76
IS 1
BP 1
EP 8
DI 10.1097/MPG.0000000000003614
PG 8
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 7J8HG
UT WOS:000904824600001
PM 36122370
DA 2026-07-24
ER

PT J
AU Gribovskaja-Rupp, I
   Melton, GB
AF Gribovskaja-Rupp, Irena
   Melton, Genevieve B.
TI Enterocutaneous Fistula: Proven Strategies and Updates
SO CLINICS IN COLON AND RECTAL SURGERY
LA English
DT Article
DE enterocutaneous fistula; enteroatmospheric fistula; spontaneous closure;
   mortality; timeline
ID VACUUM-ASSISTED CLOSURE; NUTRITIONAL SUPPORT; SMALL-BOWEL;
   PARENTERAL-NUTRITION; ABDOMINAL WOUNDS; CROHNS-DISEASE; MANAGEMENT;
   SOMATOSTATIN; OCTREOTIDE; EXPERIENCE
AB Management of enterocutaneous fistula represents one of the most protracted and difficult problems in colorectal surgery with substantial morbidity and mortality rates. This article summarizes the current classification systems and successful management protocols, provides an in-depth review of fluid resuscitation, sepsis control, nutrition management, medication management of output quantity, wound care, nonoperative intervention measures, operative timeline, and considerations, and discusses special considerations such as inflammatory bowel disease and enteroatmospheric fistula.
C1 [Gribovskaja-Rupp, Irena] Univ Iowa, Dept Surg, Iowa City, IA 52242 USA.
   [Melton, Genevieve B.] Univ Minnesota, Div Colon & Rectal Surg, 420 Delaware St SE,Mayo Med Code 450, Minneapolis, MN 55455 USA.
C3 University of Iowa; University of Minnesota System; University of
   Minnesota Twin Cities
RP Melton, GB (通讯作者)，Univ Minnesota, Div Colon & Rectal Surg, 420 Delaware St SE,Mayo Med Code 450, Minneapolis, MN 55455 USA.
EM gmelton@umn.edu
RI Melton-Meaux, Genevieve/HSE-3064-2023
OI Melton-Meaux, Genevieve/0000-0001-5193-1663
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   [No title captured]
   [No title captured]
NR 73
TC 97
Z9 127
U1 0
U2 13
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1531-0043
EI 1530-9681
J9 CLIN COLON RECT SURG
JI Clin. Colon Rectal Surg.
PD JUN
PY 2016
VL 29
IS 2
BP 130
EP 137
DI 10.1055/s-0036-1580732
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA DL9MB
UT WOS:000375966300011
PM 27247538
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Jiang, X
   Jiao, GQ
   Li, MQ
   Rong, XS
AF Jiang, Xia
   Jiao, Guoqing
   Li, Mingqiu
   Rong, Xiaosong
TI Using antibiotic-loaded bone cement for a patient with deep sternal
   wound infection after cardiac surgery
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Antibiotic-loaded bone cement; Sternal dehiscence; Deep sternal wound
   infection
AB A 67-year-old male presented with sternal dehiscence following open cardiac surgery. Extensive debridement and attempted closure failed, and the wound had since been managed with vacuum-assisted closure therapy, with little progress. We treated him with antibiotic-loaded bone cement to repair the wound defect. After 3 weeks, the wound healed with excellent result. To our knowledge, this is the first report of antibiotic-loaded bone cement for deep sternal wound infection.
C1 [Jiang, Xia; Jiao, Guoqing; Li, Mingqiu; Rong, Xiaosong] Nanjing Med Univ, Dept Cardiovasc Surg, Wuxi Peoples Hosp, Wuxi Affiliated Hosp, Wuxi 214203, Jiangsu, Peoples R China.
C3 Jiangnan University; Nanjing Medical University
RP Li, MQ; Rong, XS (通讯作者)，Nanjing Med Univ, Dept Cardiovasc Surg, Wuxi Peoples Hosp, Wuxi Affiliated Hosp, Wuxi 214203, Jiangsu, Peoples R China.
EM lmq.2109@163.com; rxswx@163.com
CR Bistolfi Alessandro, 2011, ISRN Orthop, V2011, P290851, DOI 10.5402/2011/290851
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   Kaul P, 2017, J CARDIOTHORAC SURG, V12, DOI 10.1186/s13019-017-0656-7
   Luu A, 2013, J ARTHROPLASTY, V28, P1490, DOI 10.1016/j.arth.2013.02.035
   Phoon PHY, 2020, J CARDIOTHOR VASC AN, V34, P1602, DOI 10.1053/j.jvca.2019.09.019
NR 5
TC 1
Z9 1
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN 1
PY 2022
VL 34
IS 6
BP 1150
EP 1151
DI 10.1093/icvts/ivab332
EA NOV 2021
PG 2
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 1T4SN
UT WOS:000789481800001
PM 34849902
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Riedl, JC
   Gericke, A
   Engelmann, J
   Vossmerbaeumer, U
AF Riedl, J. C.
   Gericke, A.
   Engelmann, J.
   Vossmerbaeumer, U.
TI Self-inflicted eye injury
SO OPHTHALMOLOGE
LA German
DT Article
DE Borderline personality disorder; Self-injurious behavior; Vacuum
   assisted closure; Eyelid abscess; Eyeball reconstruction
ID PREVALENCE
AB Self-injurious behavior (nonsuicidal self-injury, NNSI) is acommon phenomenon and occurs in Germany, especially in adolescence, with alifetime prevalence of 25-35%. In adulthood autoaggressive behavior is usually associated with mental illness, such as borderline personality disorder, as in the presented case. Eye injuries are rare. The treating physician is faced with the difficulty of correctly classifying the injury and clarifying suicidal intentions. Patient care requires alot of patience, empathy and time and has to include psychosocial aspects.
C1 [Riedl, J. C.; Gericke, A.; Vossmerbaeumer, U.] Univ Med Mainz, Augenklin & Poliklin, Langenbeckstr 1, D-55131 Mainz, Germany.
   [Engelmann, J.] Univ Med Mainz, Klin Psychiat & Psychotherapie, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP Riedl, JC (通讯作者)，Univ Med Mainz, Augenklin & Poliklin, Langenbeckstr 1, D-55131 Mainz, Germany.
EM Jana.Riedl@unimedizin-mainz.de
CR Bohus M, 2011, NERVENARZT, V82, P16, DOI 10.1007/s00115-010-3126-1
   Bohus M., 2006, DTSCH ARZTEBLATT, V103, P3345
   Brunner R, 2014, J CHILD PSYCHOL PSYC, V55, P337, DOI 10.1111/jcpp.12166
   Giers JC, 2017, KLIN MONATSBL AUGENH, V234, P36, DOI 10.1055/s-0042-121807
   Kleindienst N, 2008, J NERV MENT DIS, V196, P230, DOI 10.1097/NMD.0b013e3181663026
   Nitkowski D, 2011, FORTSCHR NEUROL PSYC, V79, P9, DOI 10.1055/s-0029-1245772
   Trull TJ, 2010, J PERS DISORD, V24, P412, DOI 10.1521/pedi.2010.24.4.412
   Zanarini MC, 2008, ACTA PSYCHIAT SCAND, V117, P177, DOI 10.1111/j.1600-0447.2008.01155.x
NR 8
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0941-293X
EI 1433-0423
J9 OPHTHALMOLOGE
JI Ophthalmologe
PD APR
PY 2019
VL 116
IS 4
BP 372
EP 375
DI 10.1007/s00347-018-0740-y
PG 4
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ophthalmology
GA HT9BA
UT WOS:000464858200011
PM 29881876
DA 2026-07-24
ER

PT J
AU Gauntt, J
   Cox, VK
   Duffy, V
   Deitemyer, M
   Lloyd, E
   Bigelow, A
   McConnell, P
   Simsic, J
AF Gauntt, Jennifer
   Cox, Virginia Kathleen
   Duffy, Vicky
   Deitemyer, Matt
   Lloyd, Eric
   Bigelow, Amee
   McConnell, Patrick
   Simsic, Janet
TI Negative pressure therapy for ECMO cannula stabilization
SO PERFUSION-UK
LA English
DT Article
DE extracorporeal membrane oxygenation; negative pressure therapy;
   pediatrics
ID VACUUM-ASSISTED CLOSURE; WOUND MANAGEMENT; MEDIASTINITIS
AB Cannula stabilization for extracorporeal membrane oxygenation (ECMO) is important for patient mobilization and rehabilitation. Limitations to mobilization on ECMO include staff discomfort and cannula instability. We utilized the technique of negative pressure therapy for ECMO cannula stabilization to improve mobilization. Negative pressure therapy for ECMO cannula stabilization can be utilized safely for a variety of cannulation sites in any patient age from newborns to adults. This wound management strategy may facilitate patient mobilization and rehabilitation therapies in addition to extending cannula site duration.
C1 [Gauntt, Jennifer; Cox, Virginia Kathleen; Duffy, Vicky; Deitemyer, Matt; Lloyd, Eric; Bigelow, Amee; McConnell, Patrick; Simsic, Janet] Nationwide Childrens Hosp, Heart Ctr, 700 Childrens Dr, Columbus, OH 43205 USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital
RP Gauntt, J (通讯作者)，Nationwide Childrens Hosp, Heart Ctr, 700 Childrens Dr, Columbus, OH 43205 USA.
EM Jennifer.Gauntt@nationwidechildrens.org
RI ; Lloyd, Eric/E-3530-2011
OI Gauntt, Jennifer/0000-0003-4955-0938; Lloyd, Eric/0009-0001-0347-1719
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   de Leon JM, 2009, ADV SKIN WOUND CARE, V22, P122, DOI 10.1097/01.ASW.0000305452.79434.d9
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   Hiramatsu Takeshi, 2008, Asian Cardiovasc Thorac Ann, V16, pe45
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ugaki S, 2010, INTERACT CARDIOV TH, V11, P247, DOI 10.1510/icvts.2010.235903
NR 14
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0267-6591
EI 1477-111X
J9 PERFUSION-UK
JI Perfusion-UK
PD MAR
PY 2025
VL 40
IS 2
BP 343
EP 347
DI 10.1177/02676591241236640
EA FEB 2024
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Y3Y9E
UT WOS:001168759600001
PM 38400702
DA 2026-07-24
ER

PT J
AU Xu, M
   Wang, Y
   Ma, X
   Liu, Y
   Xue, C
   Dai, H
AF Xu, M.
   Wang, Y.
   Ma, Xi.
   Liu, Y.
   Xue, C.
   Dai, H.
TI 撤稿声明: Simplified and Modified Limberg Flap Plus Vacuum-Assisted Closure
   for Treatment of Sacrococcygeal Pilonidal Sinus Disease
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 10 September 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.
CR Xu MZ, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14353
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70596
DI 10.1111/iwj.70596
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0104
UT WOS:001623112100001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gaston, RG
   Kuremsky, MA
AF Gaston, R. Glenn
   Kuremsky, Marshall A.
TI Postoperative Infections: Prevention and Management
SO HAND CLINICS
LA English
DT Article
DE Postoperative; Infection; Hand; Osteomyelitis; Wrist
ID RESISTANT STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED CLOSURE;
   RHEUMATOID-ARTHRITIS PATIENTS; SURGICAL WOUND-INFECTION; FLEXIBLE
   IMPLANT ARTHROPLASTY; UPPER EXTREMITY INFECTIONS; ELECTIVE HAND SURGERY;
   LYMPH-NODE DISSECTION; SEPTIC ARTHRITIS; PROPHYLACTIC ANTIBIOTICS
AB Postoperative infections continue to be a challenging problem. The incidence of bacterial antibiotic resistance such as methicillin-resistant Staphylococcus aureus is rising. There are numerous intrinsic patient factors that should be optimized before surgery to minimize the risk of surgical site infections. When postoperative infections develop, treatment must be individualized. This article outlines the principles that can help guide treatment.
C1 [Gaston, R. Glenn] OrthoCarolina, Charlotte, NC 28207 USA.
   [Kuremsky, Marshall A.] Carolinas Med Ctr, Dept Orthoped, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center
RP Gaston, RG (通讯作者)，OrthoCarolina, 1915 Randolph Rd, Charlotte, NC 28207 USA.
EM glenngaston@hotmail.com
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NR 136
TC 17
Z9 21
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0712
EI 1558-1969
J9 HAND CLIN
JI Hand Clin.
PD MAY
PY 2010
VL 26
IS 2
BP 265
EP +
DI 10.1016/j.hcl.2010.01.002
PG 17
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 612HK
UT WOS:000278887200012
PM 20494752
DA 2026-07-24
ER

PT J
AU Frel, KB
   Dean, J
   Bacare, B
   Burch, T
   Kureshi, IU
   Chozick, B
   Bulsara, KR
AF Frel, Khaoula Ben Hal
   Dean, Jordan
   Bacare, Bassil
   Burch, Taylor
   Kureshi, Inam U.
   Chozick, Bruce
   Bulsara, Ketan R.
TI The History of the Development and Use of Suction Devices in
   Neurosurgery
SO WORLD NEUROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BRAIN; IRRIGATION; ASPIRATION; REMOVAL; SYSTEM;
   INSTRUMENTATION; INFECTIONS; DIEULAFOY; SURGERY
AB This article reviews the major devices, individuals, and other historical landmarks in the development of suction in the field of neurosurgery, where the operating fields are characteristically deep and narrow. Our review spans the 159 years since the first use of aspiration in surgery to modern applications. This report exemplifies a comprehensive history of suction, the minute iteration of devices, and the massive impact this technological development has had on medicine and neurosurgery.
C1 [Frel, Khaoula Ben Hal; Dean, Jordan] Univ Connecticut, Sch Med, Farmington, CT USA.
   [Bacare, Bassil] Brigham & Womens Hosp, Inpatient Operat & Care Continuum Management, Boston, MA USA.
   [Burch, Taylor; Chozick, Bruce; Bulsara, Ketan R.] UConn Hlth, Dept Surg, Div Neurosurg, Farmington, CT 06030 USA.
   [Kureshi, Inam U.] Hartford Hosp, Ayer Neurosci Inst, Hartford, CT USA.
C3 University of Connecticut; Harvard University; Harvard University
   Medical Affiliates; Brigham & Women's Hospital; Hartford Hospital
RP Bulsara, KR (通讯作者)，UConn Hlth, Dept Surg, Div Neurosurg, Farmington, CT 06030 USA.
EM bulsara@uchc.edu
OI , Bassil Bacare/0009-0003-5857-0241; Ben Haj Frej,
   Khaoula/0009-0004-7888-0615
FX Conflict of interest statement: The authors declare that the article
   content was composed in the absence of any commercial or financial
   relationships that could be construed as a potential conflict of
   interest.
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NR 65
TC 1
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD OCT
PY 2024
VL 190
BP 192
EP 202
DI 10.1016/J.wNEU.2024.07.068
EA AUG 2024
PG 11
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA C6I3V
UT WOS:001290384200001
PM 39002776
DA 2026-07-24
ER

PT J
AU Xu, X
   Sun, YH
AF Xu, Xin
   Sun, Yanhua
TI Nursing countermeasures for VSD treatment of orthopedic trauma and
   infected wounds
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Vacuum sealing drainage; trauma infection; pain level; satisfaction;
   size of trauma; quality of life
ID PREVENTION; CARE
AB Objective: This study intended to investigate the effect of vacuum sealing drainage (VSD) in the treatment of orthopedic trauma and its role in the clinical care. Methods: A total of 104 patients with orthopedic trauma infection admitted to our hospital from January 2019 to January 2020 were divided into control group (n=53, receiving VSD) and study group (n=51, receiving VSD and nursing interventions) by random number table. Surgical outcomes, satisfaction, size of trauma and visual analogue scoring scale (VAS) scores were compared between the two groups. Results: The study group had shorter time to achieve granulation tissue coverage of wound base, trauma recovery and hospital stay than the control group (P<0.05). The satisfaction rate in the study group was higher compared with that in the control group (P<0.05). Before intervention, the VAS scores of the two groups and size of trauma were not significantly different (P>0.05). After intervention, VAS scores were significantly lower and trauma area was significantly smaller in both groups, and the difference was more pronounced in the study group compared with that in the control group (P<0.05). Quality of life scores were higher in the study group compared with the control group (P<0.05). Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels were lower in the study group compared with those in the control group (P<0.05). Packed cell volume (PCV), plasma viscosity, and low-cut versus high-cut whole blood viscosity were lower in the study group compared with those in the control group (P<0.05). Conclusion: VSD treatment combined with clinical nursing interventions in patients with orthopedic trauma infection could shorten the time to granulation coverage, wound healing and hospitalization time, and improve indicators of blood rheology. It could also shrink the size of trauma, decrease the level of pain and inflammatory factors, and improve the quality of life, resulting in high satisfaction.
C1 [Xu, Xin; Sun, Yanhua] Huzhou Univ, Affiliated Cent Hosp, Huzhou Cent Hosp, Dept Orthoped, Huzhou 313000, Zhejiang, Peoples R China.
C3 Huzhou University
RP Sun, YH (通讯作者)，Huzhou Univ, Affiliated Cent Hosp, Huzhou Cent Hosp, Dept Orthoped, Huzhou 313000, Zhejiang, Peoples R China.
EM sunyanhualv@163.com
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NR 29
TC 4
Z9 7
U1 1
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 9
BP 10625
EP 10632
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Research & Experimental Medicine
GA WQ0UG
UT WOS:000713537400038
PM 34650735
DA 2026-07-24
ER

PT J
AU Oeltjen, JC
   Panos, AL
   Salerno, TA
   Ricci, M
AF Oeltjen, John C.
   Panos, Anthony L.
   Salerno, Tomas A.
   Ricci, Marco
TI Complete Vacuum-Assisted Sternal Closure Following Neonatal Cardiac
   Surgery
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID MEDIASTINITIS
AB P>Vacuum-assisted closure (VAC) has been used with success in the management of adults and children with sternal infections. However, this technique has not been applied previously to neonates requiring delayed sternal closure as the sole modality of therapy. In this article, we describe the management of two newborns with hypoplastic left heart syndrome in whom complete sternal wound healing was accomplished solely by using the VAC system. The implications of this new modality of treatment are discussed.
   (J Card Surg 2009;24:748-750).
C1 [Ricci, Marco] Univ Miami, Miller Sch Med, Jackson Mem Hosp, Holtz Childrens Hosp,Div Cardiothorac Surg & Plas, Miami, FL 33136 USA.
   Univ Miami, Miller Sch Med, Div Cardiothorac Surg & Plast Surg, Miami, FL 33136 USA.
C3 University of Miami; University of Miami
RP Ricci, M (通讯作者)，Univ Miami, Miller Sch Med, Jackson Mem Hosp, Holtz Childrens Hosp,Div Cardiothorac Surg & Plas, POB 016960 R-114, Miami, FL 33136 USA.
EM mricci@med.miami.edu
RI Ricci, Marco/PRQ-7845-2026; Ricci, Marco/KIG-7617-2024
OI Ricci, Marco/0000-0001-6816-4894; Panos, Anthony/0000-0002-4208-1908
CR Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
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   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
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   Vicchio M, 2007, J THORAC CARDIOV SUR, V134, P254, DOI 10.1016/j.jtcvs.2007.03.024
NR 8
TC 3
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2009
VL 24
IS 6
BP 748
EP 750
DI 10.1111/j.1540-8191.2009.00902.x
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 516EB
UT WOS:000271523400036
PM 19765169
DA 2026-07-24
ER

PT J
AU Lan, P
   Xie, LT
   Fang, WJ
   Pan, F
   Chen, CH
   Wu, JR
AF Lan Pin
   Xie Lutao
   Fang Weijun
   Pan Feng
   Chen Chaohui
   Wu Jianrong
TI Ulnar artery pseudoaneurysm and compartment syndrome formation after
   snake bite to the left forearm
SO CLINICAL TOXICOLOGY
LA English
DT Article
DE Pseudoaneurysm; compartment syndrome; snake bite; vacuum sealing
   drainage
ID ENVENOMATION
AB Objective: To report the outcome of a patient who developed pseudoaneurysms and compartment syndrome after a Deinagkistrodon acutus snakebite.
   Case report: A 61-year-old man, bitten by Deinagkistrodon acutus in his left forearm, came to the hospital eight hours after the bite. Despite the use of antivenom and supportive therapy, the patient developed compartment syndrome of the left forearm, the tissue pressure was elevated and fasciotomy was arranged. During the initial surgery, part of the necrotic tissues was removed. Moreover, two pseudoaneurysms of the ulnar artery were identified at the second debridement and the pseudoaneurysms were removed during this surgery. The patient went through a total of four surgeries, recovered and was eventually discharged from the hospital.
   Conclusion: A snake bite by Deinagkistrodon acutus may be accompanied by pseudoaneurysms and increased intracompartmental pressure.
C1 [Lan Pin; Xie Lutao; Fang Weijun; Pan Feng; Chen Chaohui; Wu Jianrong] Lishui Cent Hosp, Dept Emergency, Lishui City, Zhejiang, Peoples R China.
RP Xie, LT (通讯作者)，ZheJiang Univ, Lishui Hosp, Dept Emergency, Lishui City, Zhejiang, Peoples R China.
RI ; Fang, Weijun/PLR-5894-2026; Wu, Jian-Rong/ISV-3861-2023; Pan,
   Feng/IXN-2297-2023
OI lutao, Xie/0000-0001-5484-0601; 
CR Brys AK, 2015, PLAST RECONSTR SURG, V3, P396
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   Toschlog EA, 2013, J AM COLL SURGEONS, V217, P726, DOI 10.1016/j.jamcollsurg.2013.05.004
NR 8
TC 10
Z9 12
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1556-3650
EI 1556-9519
J9 CLIN TOXICOL
JI Clin. Toxicol.
PY 2018
VL 56
IS 6
BP 436
EP 438
DI 10.1080/15563650.2017.1400042
PG 3
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA GH6GU
UT WOS:000433543000008
PM 29124975
DA 2026-07-24
ER

PT J
AU Liu, J
   Chen, D
   Yin, X
AF Liu, J.
   Chen, D.
   Yin, X.
TI 撤稿声明: Effect of Manual Lymphatic Drainage Combined With Vacuum Sealing
   Drainage on Axillary Web Syndrome Caused by Breast Cancer Surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
AB The above article, published online on 01 July 2022, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. In addition, further investigation by the publisher found inconsistencies in the listed inclusion criteria and participant sections and that the article did not include information on how the QOLS had been calculated. The investigation also found that some included references were irrelevant or not discoverable online. In view of the clear evidence of compromised peer review, the parties agreed that the paper must be retracted. The authors did not respond to our notice regarding the retraction.
CR Liu JY, 2023, INT WOUND J, V20, P183, DOI 10.1111/iwj.13862
NR 1
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70555
DI 10.1111/iwj.70555
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9897
UT WOS:001623091400001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Willmore, J
   Wrotslavsky, P
AF Willmore, James
   Wrotslavsky, Philip
TI Preoperative contaminated wound management using short-term negative
   pressure wound therapy with instillation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; diabetic foot ulcer; dressing; infection; lower extremity;
   surgical wound dehiscence; ulcer; wound; wounds; wound cleansing; wound
   healing; wound treatment
ID LAVAGE; INFECTION; OUTBREAK; OUTCOMES
AB Background: The short-term application of negative pressure wound therapy with instillation and dwell time (NPWTi-d) enables the delivery of topical wound solutions, the solubilisation of debris and cleansing of the wound bed. The application of NPWTi-d may support the transition of the wound to a more manageable state and minimises the use of more invasive techniques.
   Method: In this case series, we describe the process of applying NPWTi-d early as part of a contaminated wound treatment plan.
   Results: The case series included 15 patients in the preoperative setting. Wound types included surgical dehiscence, hard-to-heal wounds, heel pressure ulcers, diabetic foot ulcers, a cat bite and an amputation left open. Normal saline or a 0.125% sodium hypochlorite solution were instilled and allowed to dwell for five minutes, followed by 15 minutes of continuous negative pressure at -125mmHg. NPWTi-d was continued for 4-36 hours, or until the operating room became available. After NPWTi-d, we observed a decreased amount of devitalised tissue in the wound bed and reduced oedema and erythema in the periwound area. Patient white blood cells also significantly decreased in all cases after NPWTi-d (p<0.001).
   Conclusion: Short-term use of NPWTi-d may be a useful option for supporting the surgical treatment of contaminated lower extremity wounds.
C1 [Willmore, James; Wrotslavsky, Philip] Adv Foot & Ankle Ctr San Diego, San Diego, CA 92121 USA.
RP Wrotslavsky, P (通讯作者)，Adv Foot & Ankle Ctr San Diego, San Diego, CA 92121 USA.
EM drphilipw@gmail.com
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NR 21
TC 6
Z9 6
U1 0
U2 4
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2021
VL 30
IS 12
BP 994
EP 1000
DI 10.12968/jowc.2021.30.12.994
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XN8PR
UT WOS:000729761400005
PM 34882001
DA 2026-07-24
ER

PT J
AU Poillucci, G
   Podda, M
   Russo, G
   Perri, SG
   Ipri, D
   Manetti, G
   Lolli, MG
   De Angelis, R
AF Poillucci, Gaetano
   Podda, Mauro
   Russo, Giulia
   Perri, Sergio Gaetano
   Ipri, Domenico
   Manetti, Gabriele
   Lolli, Maria Giulia
   De Angelis, Renato
TI Open abdomen closure methods for severe abdominal sepsis: a
   retrospective cohort study
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Open abdomen; Abdominal sepsis; Bogota-Bag; Negative pressure wound
   therapy; Emergency surgery
ID PRIMARY FASCIAL CLOSURE; DAMAGE CONTROL; COMPARTMENT SYNDROME; OPEN
   MANAGEMENT; SEPTIC SHOCK; VACUUM; OPERATION; PRESSURE; FISTULAS
AB Purpose The open abdomen (OA) procedure as part of damage control surgery represents a significant surgical advance in severe intra-abdominal infections. Major techniques used for OA are negative pressure wound therapy (NPWT) and non-NPWT. The aim of this retrospective study is to evaluate the effects of different abdominal closure methods and their outcomes in patients presenting with abdominal sepsis treated with OA. Materials and methods We retrospectively analyzed clinical outcomes of patients affected by severe intra-abdominal sepsis treated with OA. Demographic features, mortality prediction score, abdominal closure methods, length of hospital stay, complications and mortality rates of patients were determined and compared. Results This study included 106 patients, of whom 77 underwent OA with NPWT and 29 with non-NPWT. OA duration was longer in NPWT patients (p = 0.007). In-hospital mortality rates in NPWT and in non-NPWT patients were 40.3% and 51.7%, respectively (p = 0.126), with an overall 30-day mortality rate of 18.2% and 51.7%, respectively (p = 0.0002). After emergency colorectal surgery, patients who underwent OA with NPWT had a lower rate of colostomy (p = 0.025). Conclusions NPWT is the best temporary abdominal closure technique to decrease mortality and colostomy rates in patients managed with OA for severe intra-abdominal infections.
C1 [Poillucci, Gaetano] Policlin Univ Umberto I, Dept Gen & Specialized Surg Paride Stefanini, Viale Policlin 155, Rome 00161, Italy.
   [Podda, Mauro] Univ Cagliari, Policlin Univ D Casula, Dept Gen Emergency & Minimally Invas Surg, Monserrato, Italy.
   [Russo, Giulia] San Camillo De Lellis Hosp, Dept Gen Surg, Rieti, Italy.
   [Perri, Sergio Gaetano; Ipri, Domenico; Manetti, Gabriele; Lolli, Maria Giulia; De Angelis, Renato] San Giovanni Addolorata Hosp, Dept Gen Surg, Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; University
   of Cagliari; Azienda Ospedaliera San Giovanni Addolorata
RP Poillucci, G (通讯作者)，Policlin Univ Umberto I, Dept Gen & Specialized Surg Paride Stefanini, Viale Policlin 155, Rome 00161, Italy.
EM gaetano.poillucci@gmail.com
RI ; Podda, Mauro/AAI-1393-2019
OI Poillucci, Gaetano/0000-0002-3961-1904; Podda, Mauro/0000-0001-9941-0883
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NR 35
TC 12
Z9 16
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2021
VL 47
IS 6
SI SI
BP 1819
EP 1825
DI 10.1007/s00068-020-01379-0
EA MAY 2020
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA XE8ZQ
UT WOS:000530776400001
PM 32377924
DA 2026-07-24
ER

PT J
AU Gregor, S
   Maegele, M
   Sauerland, S
   Krahn, JF
   Peinemann, F
   Lange, S
AF Gregor, Sven
   Maegele, Marc
   Sauerland, Stefan
   Krahn, Jan F.
   Peinemann, Frank
   Lange, Stefan
TI Negative pressure wound therapy - A vacuum of evidence?
SO ARCHIVES OF SURGERY
LA English
DT Review
ID ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; RANDOMIZED-TRIAL; SURGICAL
   WOUNDS; SKIN-GRAFTS; MANAGEMENT; DRESSINGS
AB Objective: To systematically examine the clinical effectiveness and safety of negative pressure wound therapy (NPWT) compared with conventional wound therapy.
   Data Sources: MEDLINE, EMBASE, CINAHL, and the Cochrane Library were searched. Manufacturers were contacted, and trial registries were screened.
   Study Selection: Randomized controlled trials (RCTs) and non-RCTs comparing NPWT and conventional therapy for acute or chronic wounds were included in this review. The main outcomes of interest were wound-healing variables. After screening 255 full-text articles, 17 studies remained. In addition, 19 unpublished trials were found, of which 5 had been prematurely terminated.
   Data Extraction: Two reviewers independently extracted data and assessed methodologic quality in a standardized manner.
   Data Synthesis: Seven RCTs (n=324) and 10 non-RCTs (n=278) met the inclusion criteria. The overall methodologic quality of the trials was poor. Significant differences in favor of NPWT for time to wound closure or incidence of wound closure were shown in 2 of 5 RCTs and 2 of 4 non-RCTs. A meta-analysis of changes in wound size that included 4 RCTs and 2 non-RCTs favored NPWT (standardized mean difference: RCTs, -0.57; non-RCTs, -1.30).
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C1 [Sauerland, Stefan; Krahn, Jan F.] Univ Witten Herdecke, Inst Res Operat Med, D-51109 Cologne, Germany.
   [Gregor, Sven] Univ Witten Herdecke, Dept Abdominal Vasc & Transplantat Surg, D-51109 Cologne, Germany.
   [Maegele, Marc] Univ Witten Herdecke, Dept Trauma Orthoped Surg, D-51109 Cologne, Germany.
   [Peinemann, Frank; Lange, Stefan] Inst Qual & Efficiency Hlth Care, Cologne, Germany.
   [Gregor, Sven] Reg Hosp Gummersbach, Dept Abdominal Thorac & Vasc Surg, Gummersbach, Germany.
C3 Witten Herdecke University; Witten Herdecke University; Witten Herdecke
   University
RP Sauerland, S (通讯作者)，Univ Witten Herdecke, Inst Res Operat Med, Ostmerheimer Str 200, D-51109 Cologne, Germany.
EM Stefan.Sauerland@ifom-uni-wh.de
RI /H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X
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NR 52
TC 139
Z9 159
U1 0
U2 26
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0004-0010
EI 1538-3644
J9 ARCH SURG-CHICAGO
JI Arch. Surg.
PD FEB
PY 2008
VL 143
IS 2
BP 189
EP 196
DI 10.1001/archsurg.2007.54
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 259GG
UT WOS:000252927200019
PM 18283145
DA 2026-07-24
ER

PT J
AU Xiao, SO
   Wang, WX
   Zhao, CY
   Ren, P
   Dong, LW
   Zhang, H
   Ma, FX
   Li, XY
   Bian, YQ
AF Xiao, Shuao
   Wang, Wenxuan
   Zhao, Congying
   Ren, Pan
   Dong, Liwei
   Zhang, Hao
   Ma, Fuxin
   Li, Xueyong
   Bian, Yongqian
TI A new mechanism in negative pressure wound therapy: interleukin-17
   alters chromatin accessibility profiling
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE chromatin accessibility; IL-17; NPWT; wound healing
ID IL-17
AB Negative pressure wound therapy (NPWT) is extensively used in clinical settings to enhance the healing of wounds. Despite its widespread use, the molecular mechanisms driving the efficacy of NPWT have not been fully elucidated. In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a Western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting reepithelialization, extracellular matrix (ECM) synthesis, and proliferation, which mainly occurred in the early stage of wound healing. These differentially expressed genes (DEGs) in NPWT wounds versus control wounds were enriched in the IL-17 signaling pathway. IL-17 was identified as an upregulated factor following NPWT in skin wounds. Moreover, the IL-17 inhibitor secukinumab (SEC) could abolish the promoting effect of NPWT on wound healing. Importantly, chromatin accessibility profiles were altered following NPWT and IL-17 stimulation in skin fibroblasts. Our findings suggest that NPWT upregulates IL-17 to promote wound healing by altering chromatin accessibility, which is a novel mechanism for NPWT's efficacy in wound healing.
C1 [Xiao, Shuao; Zhao, Congying; Ren, Pan; Ma, Fuxin; Li, Xueyong; Bian, Yongqian] Air Force Med Univ, Affiliated Hosp 2, Dept Plast & Burn Surg, Xian, Peoples R China.
   [Wang, Wenxuan] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Burn Plast & Wound Repair, Xiamen, Peoples R China.
   [Dong, Liwei] Air Force Med Univ, Affiliated Hosp 1, Dept Plast Surg, Xian, Peoples R China.
   [Zhang, Hao] Joint Logist Support Force Chinese PLA, Dept Plast & Burn Surg, Puer, Peoples R China.
C3 Air Force Medical University; Xiamen University; Air Force Medical
   University
RP Li, XY; Bian, YQ (通讯作者)，Air Force Med Univ, Affiliated Hosp 2, Dept Plast & Burn Surg, Xian, Peoples R China.
EM lixueyong641123@163.com; yongqianbian@163.com
RI Dong, Liwei/IQV-1924-2023
OI Dong, Liwei/0000-0002-7359-6664
FU Key Research and Development Projects of Shaanxi Province
   [2020ZDLSF04-13]
FX This research was supported by the Key Research and Development Projects
   of Shaanxi Province (Grant No.:2020ZDLSF04-13).
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NR 40
TC 3
Z9 3
U1 2
U2 12
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD JUL 29
PY 2024
VL 327
IS 1
BP C193
EP C204
DI 10.1152/ajpcell.00650.2023
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA YW1N3
UT WOS:001271430600001
PM 38682240
DA 2026-07-24
ER

PT J
AU Sun, YW
AF Sun, Yanwei
TI Antibiotic-Loaded Bone Cement Combined with Negative Pressure Wound
   Therapy for Treating Sacrococcygeal Wound Following Sacral Chordoma
   Resection: A Case Report
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Case Report; Antibiotic-Loaded Bone Cement; Ne g ative Pressure Wound
   Thera py; Wound; Sacrococc yg eal Chordoma; nthetic Dura Substitutes
ID FLAP; RECONSTRUCTION; MANAGEMENT; CLOSURE
AB BACKGROUND: Sacral chordoma is a rare, malignant primary bone tumor with subtle clinical manifestations. The extensive cavity and soft tissue defect after radical resection of the tumor can lead to complications such as sacrococcygeal skin necrosis, infection, cerebrospinal fluid (CSF) leakage, and delayed healing or nonhealing. PURPOSE: To describe the treatment effect of the combination use of antibiotic-loaded bone cement (ALBC), a gluteus maximus muscle flap, and negative pressure wound therapy (NPWT) on the nonhealing sacrococcygeal wound after sacral chordoma resection. CASE REPORT: A 67-year-old woman with a sacrococcygeal wound following sacral chordoma resection was admitted to the hospital. In the 2 -stage surgery, the internal fixation and synthetic dura substitute were exposed and CSF leakage was found after debridement, a gluteus maximus muscle flap was used to cover the synthetic dura substitute to address the CSF leakage, ALBC was used to cover the internal fixation, and a modified NPWT system was fixed to the wound for improved flushing and drainage. RESULTS: The previously nonhealing wound healed 3 weeks postoperatively, and satisfactory recovery was achieved by 6-month follow-up. CONCLUSION: This case report suggests that the combination use of ALBC, gluteus maximus muscle flap, and NPWT can effectively promote sacrococcygeal wound healing after chordoma resection.
C1 [Sun, Yanwei] Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
RP Sun, YW (通讯作者)，Zibo Cent Hosp, Dept Burns & Plast Surg, 54 Gong Qing Tuan Xi Rd, Zibo 255036, Shandong, Peoples R China.
EM syanwei005@163.com
RI sun, yanwei/LFS-0201-2024
CR Alan Ozkan, 2018, J Med Case Rep, V12, P239, DOI [10.1186/s13256-018-1784-y, 10.1186/s13256-018-1784-y]
   Chen WJ, 2016, SAUDI MED J, V37, P1140, DOI 10.15537/smj.2016.10.15682
   Chugh R, 2007, ONCOLOGIST, V12, P1344, DOI 10.1634/theoncologist.12-11-1344
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   Housari G, 2013, CLIN TRANSL ONCOL, V15, P327, DOI 10.1007/s12094-012-0919-7
   Liu C, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/2429136
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   Park HS, 2016, ANN PLAS SURG, V77, P332, DOI 10.1097/SAP.0000000000000600
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   Zannis J, 2009, ANN PLAS SURG, V62, P407, DOI 10.1097/SAP.0b013e3181881b29
NR 15
TC 0
Z9 0
U1 0
U2 0
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD NOV
PY 2023
VL 69
IS 4
AR 23008
DI 10.25270/wmp.23008
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA UZ5V3
UT WOS:001251908600004
PM 38118069
DA 2026-07-24
ER

PT J
AU Wang, Q
   Yang, XL
   Wei, ZY
   Lin, TL
   Wang, LF
AF Wang, Qian
   Yang, Xiaolan
   Wei, Zhiyi
   Lin, Tianlai
   Wang, Longfeng
TI The Effect of NPWT on Odontogenic Cervical Necrotizing Fasciitis
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cervical Necrotizing fasciitis (CNF); negative pressure wound therapy
   (NPWT); odontogenic infection
AB Objective: To investigate the clinical efficacy of negative pressure wound therapy (NPWT) in the treatment of odontogenic cervical Necrotizing fasciitis (CNF). Methods: Sixteen cases of odontogenic cervical necrotizing fasciitis were randomly divided into observation group and control group after routine debridement and disinfection. The patients in the control group were treated with drainage tube and regular dressing changes, while those in the observation group were treated with NPWT. The therapeutic effects of the 2 groups were compared. Results: The frequency of operation, treatment length, and cost of treatment in the observation group were significantly less than those in the control group (P<0.05). During the treatment, the VAS (visual analog scale of pain) in the observation group was significantly lower than that in the control group (P<0.05). The levels of WBC, CRP, PCT, IL-6, and TNF-alpha in the observation group were lower than those in the control group (P<0.05). The levels of Il-10 and VEGF in the observation group were higher than those in the control group (P<0.05), the difference was statistically significant. Conclusions: The condition of odontogenic cervical necrotizing fasciitis progresses rapidly. Compared with conventional drainage and dressing change, NPWT can control infection in a short time, reduce operation frequency and treatment cost, and promote wound healing, shorten the treatment time, ease the pain of patients, improve the quality of life. The therapeutic scheme is safe, effective, and suitable for clinical application.
C1 [Wang, Qian; Wang, Longfeng] Quanzhou First Hosp, Quanzhou Med Coll, Quanzhou, Fujian, Peoples R China.
   [Yang, Xiaolan; Wei, Zhiyi] Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
   [Lin, Tianlai] Quanzhou First Hosp, Dept Intens Care Unit, Quanzhou, Fujian, Peoples R China.
RP Wei, ZY (通讯作者)，Quanzhou First Hosp, Dept Burn Intens Care Unit, 250 Dongjie Rd, Quanzhou 362000, Fujian, Peoples R China.
EM 236015379@qq.com; 278897140@qq.com; wwdoctor520@sina.com;
   LTL688@163.com; 731185317@qq.com
FU Quanzhou City Science and Technology Program [2022NS0073]
FX Supported by Quanzhou City Science and Technology Program (2022NS0073).
CR Amponsah EK, 2021, J CRANIOFAC SURG, V32, pE547, DOI 10.1097/SCS.0000000000007528
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAR-APR
PY 2025
VL 36
IS 2
BP e227
EP e231
DI 10.1097/SCS.0000000000010564
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y2I2W
UT WOS:001430420800009
PM 39283081
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Martí, MTC
   Fernandez-Gonzalez, S
   Martí, MD
   Pla, MJ
   Barahona, M
   Ponce, J
AF Climent Marti, Maria Teresa
   Fernandez-Gonzalez, Sergi
   Dolores Marti, Maria
   Jesus Pla, Maria
   Barahona, Marc
   Ponce, Jordi
TI Prophylactic incisional negative pressure wound therapy for gynaecologic
   malignancies
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE gynecologic neoplasms; laparotomy; negative-pressure wound therapy;
   postoperative care; wound healing
ID SURGICAL SITE INFECTION; LAPAROTOMY; IMPACT; COST
AB Wound complications are an important cause of postoperative morbidity among patients with gynaecologic malignancies. We evaluated whether the placement of closed-incisional negative pressure therapy (ciNPT) at the time of laparotomy for gynaecologic cancer surgery reduced wound complication rates. A retrospective cohort study with primary wound closure performed by a gynaecologic oncologist was carried out. We evaluated two cohorts of patients who underwent surgery in 2017 with standard closure and patients who underwent surgery in 2019 with the placement of prophylactic ciNPT. Postoperative outcomes were examined. A total of 143 patients were included, 85 (59.4%) vs 58 (40.6%) with standard closure and ciNPT, respectively. The total complication rate in our sample was 38.71%. The rate of surgical complications in patients treated with ciNPT was 6.9% compared with 31.8% (P = .000) in patients treated with standard closure. In the analysis of complications, a significant reduction in infections (17.1%), seromas (15.4%), and wound dehiscence (17.1%) were observed when ciNPT was applied. The median hospital stay was 8 vs 6 days in the standard closure vs ciNPT groups (P = .048). The use of the prophylactic ciNPT following a laparotomy may decrease wound complications and hospital stays in oncological patients. ciNPT could be considered as part of clinical practice in patients at high risk of wound complications, such as patients with gynaecological malignancies.
C1 [Climent Marti, Maria Teresa; Fernandez-Gonzalez, Sergi; Dolores Marti, Maria; Barahona, Marc; Ponce, Jordi] Hosp Univ Bellvitge, Dept Gynecol, Barcelona, Spain.
   [Jesus Pla, Maria] Hosp Univ Bellvitge, Dept Gynecol, Multidisciplinary Breast Canc Unit, Barcelona, Spain.
C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital
RP Fernandez-Gonzalez, S (通讯作者)，Dept Gynecol, Carrer Feixa Llarga,Idibell S-N, Barcelona 08907, Spain.
EM sfernandezg@bellvitgehospital.cat
OI Ponce, Jordi/0000-0002-0613-2261; CLIMENT MARTÍ, MARIA
   TERESA/0000-0002-2533-7983
CR Borchardt RA, 2018, JAAPA-J AM ACAD PHYS, V31, P52, DOI 10.1097/01.JAA.0000531052.82007.42
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NR 24
TC 4
Z9 7
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2022
VL 19
IS 2
BP 272
EP 277
DI 10.1111/iwj.13628
EA JUL 2021
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YH4HX
UT WOS:000673959600001
PM 34268886
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Semenic, D
   Bukovec, P
AF Semenic, Danijela
   Bukovec, Petra
TI Advanced Treatment Options of Pyoderma Gangrenosum Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE immunosuppression; negative pressure wound therapy; pyoderma
   gangrenosum; surgery; ulcer
ID PLATELET-RICH PLASMA; PRESSURE WOUND THERAPY; SURGICAL-TREATMENT;
   UPDATE; MODEL; RISK; GEL
AB Introduction. Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with autoimmune disease that, despite published literature, still poses diagnostic and therapeutic challenges due to its lack of serological and histological markers and wide possibility of differential diagnosis. Although immunosuppressive therapy usually is the first-line treatment, it has a long-lasting, unpredictable treatment course, thus necessitating the need for new treatment options. This report highlights 2 cases of PG ulcers treated with different methods that show a potentially faster healing time, as well as a review of advanced treatment options for PG. Case Reports. Two men (21 years old and 64 years old) presented with PG ulcers and underwent 2 different treatment courses. The 21-year-old man received negative pressure wound therapy (NPWT) with a nonadhesive, less-invasive, skin-contact interface layer on the polyurethane foam. Stimulated growth of granulation tissue accelerated healing and prepared the wound bed for further epithelization. The second patient, the 64-yearold man, underwent treatment with autologous platelet-rich fibrin, which supplied the ulcer with growth factors and accelerated epithelialization. Conclusions. The new possibilities offered by NPWT with nonadhesive foam and regenerative medicine are typically affordable, effective, safe, and painless for the patient. Both methods were noninvasive, did not accelerated the pathergy phenomenon, and showed a potential for faster healing of PG ulcers.
C1 Univ Ljubljana, Dept Surg Infect, Univ Med Ctr Ljubljana, Ljubljana, Slovenia.
   Univ Ljubljana, Med Fac, Ljubljana, Slovenia.
C3 University of Ljubljana; University Medical Centre Ljubljana; University
   of Ljubljana
RP Semenic, D (通讯作者)，Univ Med Ctr Ljubljana, Dept Surg Infect, Zaloska Cesta 7, Ljubljana 1000, Slovenia.
EM danijela.semenic@kclj.si
CR Ahmed M, 2017, ANN VASC SURG, V38, P206, DOI 10.1016/j.avsg.2016.04.023
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NR 29
TC 3
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2020
VL 32
IS 2
BP E1
EP E5
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5JC
UT WOS:000519745700001
PM 32155124
DA 2026-07-24
ER

PT J
AU Frear, CC
   Griffin, BR
   Cuttle, L
   Kimble, RM
   McPhail, SM
AF Frear, Cody C.
   Griffin, Bronwyn R.
   Cuttle, Leila
   Kimble, Roy M.
   McPhail, Steven M.
TI Cost-effectiveness of adjunctive negative pressure wound therapy in
   paediatric burn care: evidence from the SONATA in C randomised
   controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ASSISTED CLOSURE DEVICE; PARTIAL-THICKNESS BURNS; SUBATMOSPHERIC
   PRESSURE; ECONOMIC-EVALUATION; UTILITY ANALYSIS; HEALING TIME;
   MANAGEMENT; SCARS; EPIDEMIOLOGY; PROGRESSION
AB Negative pressure wound therapy (NPWT) has been shown to improve clinical outcomes for children with burns by accelerating wound re-epithelialisation. Its effects on healthcare costs, however, remain poorly understood. The aim of this study was to evaluate the cost-effectiveness of NPWT from a healthcare provider perspective using evidence from the SONATA in C randomised controlled trial, in which 101 children with small-area burns were allocated to either standard care (silver-impregnated dressings) or standard care in combination with adjunctive NPWT. The primary outcome, time to re-epithelialisation, was assessed through a blinded photographic review. Resource usage and costs were prospectively recorded for each participant for up to 6 months. Incremental cost-effectiveness ratios and dominance probabilities were estimated and uncertainty quantified using bootstrap resampling. Mean costs per participant-including dressings, labour, medication, scar management, and theatre operations-were lower in the NPWT group (AUD $903.69) relative to the control group (AUD $1669.01). There was an 89% probability that NPWT was dominant, yielding both faster re-epithelialisation and lower overall costs. Findings remained robust to sensitivity analyses employing alternative theatre costs and time-to-re-epithelialisation estimates for grafted patients. In conclusion, adjunctive NPWT is likely to be a cost-effective and dominant treatment for small-area paediatric burns (ANZCTR.org.au:ACTRN12618000256279).
C1 [Frear, Cody C.; Griffin, Bronwyn R.; Cuttle, Leila; Kimble, Roy M.] Univ Queensland, Child Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.
   [Frear, Cody C.; Kimble, Roy M.] Univ Queensland, Fac Med, Herston, Qld, Australia.
   [Griffin, Bronwyn R.] Griffith Univ, Menzies Hlth Inst Queensland, Southport, Qld, Australia.
   [Cuttle, Leila] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Kimble, Roy M.] Queensland Childrens Hosp, South Brisbane, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia.
   [McPhail, Steven M.] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat, Brisbane, Qld, Australia.
   [McPhail, Steven M.] Metro South Hlth, Clin Informat Directorate, Brisbane, Qld, Australia.
C3 University of Queensland; University of Queensland; Griffith University;
   Queensland University of Technology (QUT); Childrens Health Queensland
   Hospital & Health Service; Queensland Childrens Hospital; Queensland
   University of Technology (QUT); Queensland University of Technology
   (QUT)
RP Frear, CC (通讯作者)，Univ Queensland, Child Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.; Frear, CC (通讯作者)，Univ Queensland, Fac Med, Herston, Qld, Australia.
EM cody.frear@uqconnect.edu.au
RI McPhail, Steven/JMR-2141-2023; Griffin, Bronwyn/AEB-6299-2022; Kimble,
   Roy/B-4160-2011; Cuttle, Leila/C-5223-2008
OI McPhail, Steven/0000-0002-1463-662X; Griffin,
   Bronwyn/0000-0002-6182-9125; Cuttle, Leila/0000-0002-2282-4815
FU Australian Government, National Health and Medical Research Council
   [APP1196436, APP1130862, APP1161138]
FX The authors thank the children and families who participated in the
   SONATA in C trial, without whom this research would not have been
   possible. They are grateful for the support of the clinicians at the
   Pegg Leditschke Children's Burn Centre and Queensland Children's
   Hospital Emergency Department. They would further like to acknowledge
   Crystle Gambetta, Fiona Gregory, Frank Hurley, Catherine McMillan, and
   Kate Miller for their generous contributions to the collection of
   costing details. B.R.G., L.C. and S.M.M. acknowledge funding from the
   Australian Government, National Health and Medical Research Council
   (APP1196436, APP1130862 and APP1161138, respectively).
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NR 50
TC 16
Z9 17
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 17
PY 2021
VL 11
IS 1
AR 16650
DI 10.1038/s41598-021-95893-9
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UC7GU
UT WOS:000686690900072
PM 34404842
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zwanenburg, PR
   Timmermans, FW
   Timmer, AS
   Middelkoop, E
   Tol, BT
   Lapid, O
   Obdeijn, MC
   Gans, SL
   Boermeester, MA
AF Zwanenburg, Pieter R.
   Timmermans, Floyd W.
   Timmer, Allard S.
   Middelkoop, Esther
   Tol, Berend T.
   Lapid, Oren
   Obdeijn, Miryam C.
   Gans, Sarah L.
   Boermeester, Marja A.
TI A systematic review evaluating the influence of incisional Negative
   Pressure Wound Therapy on scarring
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
ID SURGICAL WOUNDS; MANAGEMENT; DEVICE; TRIAL
AB Pathological scars can result in functional impairment, disfigurement, a psychological burden, itch, and even chronic pain. We conducted a systematic review to investigate the influence of incisional Negative Pressure Wound Therapy (iNPWT) on scarring. PubMed, EMBASE and CINAHL were searched for preclinical and clinical comparative studies that investigated the influence of iNPWT on scarring-related outcomes. Individual studies were assessed using the OHAT Risk of Bias Rating Tool for Human and Animal studies. The body of evidence was rated using OHAT methodology. Six preclinical studies and nine clinical studies (377 patients) were identified. Preclinical studies suggested that iNPWT reduced lateral tension on incisions, increased wound strength, and reduced scar width upon histological assessment. Two clinical studies reported improved patient-reported scar satisfaction as measured with the PSAS (1 year after surgery), POSAS, and a VAS (both 42, 90, and 180 days after surgery). Five clinical studies reported improved observer-reported scar satisfaction as measured with the VSS, SBSES, OSAS, MSS, VAS, and POSAS (7, 15, 30, 42, 90, 180, and 365 days after surgery). Three clinical studies did not detect significant differences at any point in time (POSAS, VAS, and NRS). Because of imprecision concerns, a moderate level of evidence was identified using OHAT methodology. Preclinical as well as clinical evidence indicates a beneficial influence of iNPWT on scarring. Moderate level evidence indicates that iNPWT decreases scar width and improves patient and observer-reported scar satisfaction.
C1 [Zwanenburg, Pieter R.; Timmer, Allard S.; Tol, Berend T.; Gans, Sarah L.; Boermeester, Marja A.] Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
   [Timmermans, Floyd W.; Middelkoop, Esther] Vrije Univ Amsterdam, Dept Plast Reconstruct & Hand Surg, Amsterdam Movement Sci Res Inst, Amsterdam UMC, Amsterdam, Netherlands.
   [Middelkoop, Esther] Red Cross Hosp, Assoc Dutch Burn Ctr, Beverwijk, Netherlands.
   [Lapid, Oren; Obdeijn, Miryam C.] Univ Amsterdam, Amsterdam UMC, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; University of Amsterdam
RP Boermeester, MA (通讯作者)，Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
EM m.a.boermeester@amsterdamumc.nl
RI ; Middelkoop, Esther/M-3735-2014; Lapid, Oren/S-6331-2019
OI Boermeester, Marja/0000-0003-3890-8105; Middelkoop,
   Esther/0000-0001-8843-1080; Zwanenburg, Pieter/0000-0002-0301-2838;
   Lapid, Oren/0000-0001-8921-9866
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Bijlard E, 2017, PAIN PHYSICIAN, V20, P1, DOI 10.36076/ppj.2017.2.13
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   Glaser DA, 2012, WOUNDS, V24, P308
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NR 33
TC 16
Z9 22
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2021
VL 29
IS 1
BP 8
EP 19
DI 10.1111/wrr.12858
EA AUG 2020
PG 12
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA PT3DV
UT WOS:000563905300001
PM 32789902
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Moscalu, R
   Moscalu, M
   Reid, AJ
   Domingos, M
   Stevens, A
   Wong, JKF
AF Moscalu, Roxana
   Moscalu, Mihaela
   Reid, Adam J.
   Domingos, Marco
   Stevens, Adam
   Wong, Jason K. F.
TI The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in
   Chronic Diabetic Wound Healing: A Systematic Review and Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE chronic wound healing; diabetes; diabetic foot ulcers; NPWT
ID FOOT ULCERS; EXPRESSION; INDUCTION
AB Although Negative Pressure Wound Therapy (NPWT) has been increasingly used in wound care to improve impaired healing, there is little scientific evidence supporting its role and underlying biomolecular mechanisms. Aims of the present study are to provide a quantitative analysis of recent literature investigating NPWT in diabetic wound healing focusing on healing duration, wound closure, hospitalisation period and complications, and qualitative insight into studies analysing biomolecular mechanisms. The systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024524813). 21 studies published in PubMed, Cochrane Library, EMBASE between 2019 and 2024 were included. Clinical studies indicated NPWT was superior to standard care dressings (SCD), promoting faster wound healing with significantly reduced hospitalisation times by 7.8 days (95% CI: -14.2 to -1.4, p = 0.017), and significantly reduced complications rates, particularly major and minor amputations (95% CI: -10.2 to -1.3, p = 0.01). Mechanistic in vitro and animal studies highlighted NPWT can reduce local inflammation, oxidative stress, support angiogenesis and improve scarring, essential components of normal healing. Although studies suggest NPWT is more effective than SCD for diabetic wound healing, the paucity of studies, small cohorts and scarce outcomes consistency make defining clear conclusions challenging. There is still more evidence required to fully understand NPWT's role in the complex diabetic wound healing.
C1 [Moscalu, Roxana; Reid, Adam J.; Wong, Jason K. F.] Univ Manchester, Fac Biol Med & Hlth, Div Cell Matrix Biol & Regenerat Med, Blond McIndoe Labs,Sch Biol Sci,Manchester Acad Hl, Manchester, England.
   [Moscalu, Mihaela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Prevent Med & Interdisciplinar, Iasi, Romania.
   [Reid, Adam J.; Wong, Jason K. F.] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Wythenshawe Hosp, Dept Plast Surg & Burns, Manchester, England.
   [Domingos, Marco] Univ Manchester, Sch Mech Aerosp & Civil Engn, Manchester, England.
   [Stevens, Adam] Univ Manchester, St Marys Hosp, Fac Biol Med & Hlth, Tommys Maternal & Fetal Hlth Res Ctr, 5th Floor, Manchester, England.
C3 University of Manchester; Grigore T Popa University of Medicine &
   Pharmacy; University of Manchester; Wythenshawe Hospital NHS Foundation
   Trust; Wythenshawe Hospital; Manchester University NHS Foundation Trust;
   University of Manchester; University of Manchester
RP Moscalu, R (通讯作者)，Univ Manchester, Fac Biol Med & Hlth, Div Cell Matrix Biol & Regenerat Med, Blond McIndoe Labs,Sch Biol Sci,Manchester Acad Hl, Manchester, England.
EM roxana.moscalu@postgrad.manchester.ac.uk
RI Moscalu, Mihaela/ABA-9799-2020; Reid, Adam/G-4460-2014
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN 1
PY 2026
VL 23
IS 6
AR e70961
DI 10.1111/iwj.70961
PG 18
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IU4RZ
UT WOS:001780602000001
PM 42220094
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bueno-Lledó, J
   Martinez-Hoed, J
   Bonafe-Diana, S
   Pous-Serrano, S
AF Bueno-Lledo, Jose
   Martinez-Hoed, Jesus
   Bonafe-Diana, Santiago
   Pous-Serrano, Salvador
TI Mesh Infection After Hernia Repair and Negative Pressure Wound Therapy.
   A Systematic Review
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID MANAGEMENT; COMPLICATIONS; SURGERY
AB BackgroundSurgical mesh infection (SMI) after abdominal wall hernia repair (AWHR) is a challenging and highly debatedclinical problem with no current consensus. The purpose of this review was to analyze the literature about the useof negative pressure wound therapy (NPWT) in the management of the conservative treatment of SMI and reportresults about infected mesh salvage.MethodsA systematic review of EMBASE and PUBMED was performed describing the use of NPWT in patients with SMIfollowing AWHR. Reviewed articles evaluating data about the association between clinical, demographic, analyticand surgical characteristics about SMI after AWHR were analyzed. The high heterogeneity of these studies did notallow a meta-analysis of outcomes.ResultsThe search strategy yielded 33 studies from PubMed, and 16 studies from EMBASE. NPWT was performed in 230patients across 9 studies being achieved the mesh salvage in 196 (85.2%). Of these 230 cases, 46% werepolypropylene (PPL), 9.9% polyester (PE), 16.8% polytetrafluoroethylene (PTFE), 4% biologic and 10.2%composite mesh (PPL and PTFE). Infected mesh location was onlay (43%), retromuscular (22%), preperitoneal(19%), intraperitoneal (10%) and between the oblique muscles (5%). The better option on salvageability with theuse of NPWT was the combination of macroporous PPL mesh in an extraperitoneal position (19.2% onlay, 23.3%preperitoneal, 48.8% retromuscular).ConclusionNPWT is a sufficient approach to treat SMI following AWHR. In most cases, infected prostheses can be salvagedwith this management. Further studies with a larger sample size are needed to confirm our analysis results.
C1 [Bueno-Lledo, Jose; Bonafe-Diana, Santiago; Pous-Serrano, Salvador] La Fe Hosp Univ Valencia, Dept Digest Surg, Unit Abdominal Wall Surg, Calle Gabriel Miro 28,Puerta 12, Valencia 46008, Spain.
   [Martinez-Hoed, Jesus] Hosp Rafael Angel Calderon Guardia, San Jose, Costa Rica.
RP Bueno-Lledó, J (通讯作者)，La Fe Hosp Univ Valencia, Dept Digest Surg, Unit Abdominal Wall Surg, Calle Gabriel Miro 28,Puerta 12, Valencia 46008, Spain.
EM buenolledo@hotmail.co
RI Bueno-Lledó, Jose/I-2674-2019
OI Bueno-Lledó, Jose/0000-0002-3116-5022; Pous-Serrano,
   Salvador/0000-0002-2931-0366
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NR 28
TC 7
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUN
PY 2023
VL 47
IS 6
BP 1495
EP 1502
DI 10.1007/s00268-023-06943-4
EA FEB 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK6F8
UT WOS:000936912500003
PM 36802233
DA 2026-07-24
ER

PT J
AU Papp, AA
AF Papp, Anthony A.
TI Incisional negative pressure therapy reduces complications and costs in
   pressure ulcer reconstruction
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE cost; flap; negative pressure; pressure ulcer; reconstruction
ID SPINAL-CORD-INJURY; WOUND THERAPY; OBESE-PATIENTS; OUTCOMES; SURGERY;
   RISK; INFECTIONS; MANAGEMENT; SORES; FLAP
AB Complications after pressure ulcer reconstruction are common. A complication rate of 21% to 58% and a 27% wound recurrence has been reported. The aim of this study was to decrease postoperative wound-healing complications with incisional negative pressure wound therapy (iNPWT) postoperatively. This was a prospective non-randomised trial with a historic control. Surgically treated pressure ulcer patients receiving iNPWT were included in the prospective part of the study (Treatment group) and compared with the historic patient cohort of all consecutive surgically treated pressure ulcer patients during a 2-year period preceding the initiation of iNPWT (Control). There were 24 patients in the Control and 37 in the Treatment groups. The demographics between groups were similar. There was a 74% reduction in in-hospital complications in the Treatment group (10.8% vs 41.7%, P = 0.0051), 27% reduction in the length of stay (24.8 vs 33.8 days, P = 0.0103), and a 78% reduction in the number of open wounds at 3 months (5.4 vs 25%, P = -0.0481). Recurrent wounds and history of previous surgery were risk factors for complications. Incisional negative pressure wound therapy shortens hospital stay, number of postoperative complications, and the number of recurrent open wounds at 3 months after reconstructive pressure ulcer surgery, resulting in significant cost savings.
C1 [Papp, Anthony A.] Vancouver Gen Hosp, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
   [Papp, Anthony A.] Univ British Columbia, Div Plast Surg, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia
RP Papp, AA (通讯作者)，Vancouver Gen Hosp, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.
EM anthony.papp@gmail.com
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
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NR 31
TC 21
Z9 24
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2019
VL 16
IS 2
BP 394
EP 400
DI 10.1111/iwj.13045
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HQ7VT
UT WOS:000462632200011
PM 30548531
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Raphael, A
   Gonzales, J
AF Raphael, A.
   Gonzales, J.
TI Use of cryopreserved umbilical cord with negative pressure wound therapy
   for complex diabetic ulcers with osteomyelitis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE complex wounds; diabetic foot ulcer; NPWT; osteomyelitis; cryopreserved
   umbilical cord
ID AMNIOTIC MEMBRANE
AB Objective: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality.
   Methods: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis. Change in wound size and volume, time to wound closure, and number of cUC applications were assessed.
   Results: We identified of 14 wounds in 13 patients, with an average initial wound area of (mean +/- standard devaition) 33.2 +/- 21.7cm(2) and wound volume of 52 +/- 26.2cm(3). All achieved complete re-epithelialisation with an average time to closure of 24.0 +/- 10.9 weeks, using between 2-5 cUC applications. No adverse events were noted and none of the wounds required limb amputation during the a follow-up of 24 months for each patient.
   Conclusion: The results suggest that combined use of cUC and NPWT may be effective in improving the healing of complex DFUs that present with osteomyelitis. Prospective, randomised controlled trials are warranted to confirm this efficacy as well as its potential applications in other chronic wounds.
C1 [Raphael, A.] Village Podiatry Ctr, Smyrna, GA 30082 USA.
   [Gonzales, J.] Dekalb Med Podiatr Residency, PGY3, Decatur, GA USA.
RP Raphael, A (通讯作者)，Village Podiatry Ctr, Smyrna, GA 30082 USA.
EM ARaphael@vpcenters.com
FU Amniox Medical; Acelity
FX Dr Raphael is a paid consultant for Amniox Medical and Acelity.
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NR 14
TC 16
Z9 21
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2017
VL 26
IS 10
SU S
BP S38
EP S44
DI 10.12968/jowc.2017.26.Sup10.S38
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FI9ZU
UT WOS:000412369100006
PM 28976835
DA 2026-07-24
ER

PT J
AU Fraccalvieri, M
   Sarno, A
   Gasperini, S
   Zingarelli, E
   Fava, R
   Salomone, M
   Bruschi, S
AF Fraccalvieri, Marco
   Sarno, Antonino
   Gasperini, Stefano
   Zingarelli, Enrico
   Fava, Raffaella
   Salomone, Marco
   Bruschi, Stefano
TI Can Single Use Negative Pressure Wound Therapy be an alternative method
   to manage keloid scarring? A preliminary report of a clinical and
   ultrasound/colour-power-doppler study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Compression therapy; Keloid; Mechanic forces; Negative wound pressure
   therapy; Silicone
ID HYPERTROPHIC SCARS; RISK-FACTORS; EFFICACY; PATHOGENESIS; PREVENTION
AB Keloid scarring represents a pathological healing where primary healing phenomenon is deviated from normal. Pico is a single use negative pressure wound therapy system originally introduced to manage open or just closed wounds. Pico dressing is made of silicone, and distributes an 80 mmHg negative pressure across wound bed. Combination of silicon layer and continuous compression could be a valid method to manage keloid scarring. Since November 2011, three patients were enrolled and evaluated before negative pressure treatment, at end of treatment (1 month) and 2 months later, through Vancouver Scar Scale (VSS), Visual Analog Scale (VAS) and a scoring system for itching. Ultrasound (US) and colour-power-doppler (CPD) examination was performed to evaluate thickness and vascularisation of the scar. One patient was discharged from study after 1 week. In last two patients, VSS, VAS and itching significantly improved after 1 month therapy and the results were stable after 2 months without any therapy. At end of therapy, the appearance of palisade vessels' disappeared in both cases at CPD exam; US showed a thickness reduction (average 43 center dot 8%). We propose a well-tolerated, non invasive treatment to manage keloid scarring. Prospective studies are necessary to investigate whether these preliminary observations are confirmed.
C1 [Fraccalvieri, Marco; Zingarelli, Enrico; Salomone, Marco; Bruschi, Stefano] Univ Turin, San Giovanni Battista Hosp, Dept Plast Reconstruct & Aesthet Surg, I-10126 Turin, Italy.
   [Sarno, Antonino] Giovanni Battista Hosp, Radiol Unit, Turin, Italy.
   [Gasperini, Stefano] Univ Pisa, SIRTES Int Sch Wound Repair, Pisa, Italy.
   [Fava, Raffaella] Local Hlth Unit Moncalieri, Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; AOU San Giovanni Battista-Molinette; A.O.U. Citta della Salute e
   della Scienza di Torino; AOU San Giovanni Battista-Molinette; University
   of Pisa
RP Fraccalvieri, M (通讯作者)，Univ Turin, San Giovanni Battista Molinette Hosp, Dept Reconstruct & Aesthet Plast Surg, Via Cherasco 23, I-10126 Turin, Italy.
EM marco@fraccalvieri.it
RI /AAF-4387-2019
OI Bruschi, Stefano/0000-0002-4746-9864
CR Agha R, 2011, J SURG RES, V171, P700, DOI 10.1016/j.jss.2011.07.007
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   Baryza Mary Jo, 1995, Journal of Burn Care and Rehabilitation, V16, P535, DOI 10.1097/00004630-199509000-00013
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NR 26
TC 13
Z9 17
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2013
VL 10
IS 3
BP 340
EP 344
DI 10.1111/j.1742-481X.2012.00988.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 146CF
UT WOS:000319065700018
PM 22716191
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ruhstaller, K
   Downes, KL
   Chandrasekaran, S
   Srinivas, S
   Durnwald, C
AF Ruhstaller, Kelly
   Downes, Katheryne L.
   Chandrasekaran, Suchitra
   Srinivas, Sindhu
   Durnwald, Celeste
TI Prophylactic Wound Vacuum Therapy after Cesarean Section to Prevent
   Wound Complications in the Obese Population: A Randomized Controlled
   Trial (the ProVac Study)
SO AMERICAN JOURNAL OF PERINATOLOGY
LA English
DT Article
DE cesarean delivery; negative pressure wound therapy; obese; surgical site
   infection; wound complication
ID SURGICAL SITE INFECTION; HIGH-RISK; PRESSURE; DELIVERY
AB Objective The objective of this study was to perform a randomized controlled feasibility trial investigating negative pressure wound therapy (NPWT) system versus a standard postcesarean wound care (WC) on the development of a postoperative surgical site infection (SSI) and/or a wound dehiscence in obese women.
   Study Design This is a randomized controlled feasibility trial of obese women undergoing an unscheduled cesarean delivery. Women with an initial body mass index30 kg/m (2) who were4 cm dilated were included. Women were assigned to either a NPWT or standard WC. The primary outcome was a composite of wound morbidity at 4 weeks postpartum including SSI and/or wound opening (clinicaltrials.gov, NCT02128997). Continuous variables were analyzed with t -test and Wilcoxon rank-sum tests and categorical variables with Fisher's exact test.
   Results Of 136 women randomized, 67 received NPWT and 69 received standard WC. The 4-week follow-up rate was 88%. Maternal clinical and surgical characteristics were similar between the groups. The prevalence of the composite wound morbidity outcome was not different between those with NPWT and standard WC (4.9 vs. 6.9%; p =0.71).
   Conclusion Routine clinical use of a NPWT system after cesarean delivery did not result in a significant reduction of wound morbidity over standard WC.
C1 [Ruhstaller, Kelly; Downes, Katheryne L.; Srinivas, Sindhu; Durnwald, Celeste] Univ Penn, Dept Obstet & Gynecol, Perelman Sch Med, Maternal Child Hlth Res Ctr, Philadelphia, PA 19104 USA.
   [Chandrasekaran, Suchitra] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA.
C3 University of Pennsylvania; University of Washington; University of
   Washington Seattle
RP Durnwald, C (通讯作者)，Univ Penn, Maternal & Child Hlth Ctr, 3400 Spruce St, Philadelphia, PA 19104 USA.
EM celeste.durnwald@uphs.upenn.edu
OI Chandrasekaran, Suchitra/0000-0002-5964-1190
FU National Institute of Health Reproductive Epidemiology Training Gran
   [T32-HD007440]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development [K12HD001264] Funding Source: NIH RePORTER
FX This study was supported by the National Institute of Health
   Reproductive Epidemiology Training Gran(T32-HD007440). All study devices
   were provided by Acelity. The funding sources had no role in study
   design, data collection, or analysis.
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   Swift SH, 2015, J REPROD MED, V60, P211
   Tuuli MG, 2016, NEW ENGL J MED, V374, P647, DOI 10.1056/NEJMoa1511048
NR 13
TC 36
Z9 38
U1 0
U2 6
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0735-1631
EI 1098-8785
J9 AM J PERINAT
JI Am. J. Perinatol.
PD SEP
PY 2017
VL 34
IS 11
BP 1125
EP 1130
DI 10.1055/s-0037-1604161
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA FF6BS
UT WOS:000409088700014
PM 28704847
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ramírez-Giraldo, C
   Rincón-Nieto, N
   Hernández-Vesga, J
   Turizo, JL
   Pesce, A
   Agudelo-Delgadillo, D
   Santamaría-Forero, S
   Isaza-Restrepo, A
AF Ramirez-Giraldo, Camilo
   Rincon-Nieto, Nicolas
   Hernandez-Vesga, Julian
   Turizo, Jorge Luis
   Pesce, Antonio
   Agudelo-Delgadillo, Daniel
   Santamaria-Forero, Sofia
   Isaza-Restrepo, Andres
TI Mesh-mediated fascial traction for open abdomen management to prevent
   planned ventral hernias: a retrospective cohort
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Open abdomen; Mesh-mediated fascial traction; Negative pressure wound
   therapy; Incisional hernia; Abdominal wall closure
ID PRESSURE WOUND THERAPY; CLOSURE
AB BackgroundOpen abdomen is indicated in some clinical scenarios, but it introduces new challenges like the development of planned incisional hernias; new management techniques for temporary closure in open abdomen such as negative pressure wound therapy and mesh-mediated fascial traction have shown an incidence reduction of this outcome. However, for successful abdominal wall closure rates, there is limited evidence evaluating the factors associated with it when mesh-mediated fascial traction is employed in the context of open abdomen.MethodsWe conducted a retrospective cohort analysis of patients managed with mesh-mediated fascial traction at M & eacute;deri Hospital Network from 2020 to 2025. Demographic data, clinical characteristics, surgical variables, and postoperative outcomes were systematically evaluated.ResultsNinety-two patients were included, achieving a definitive abdominal wall closure success rate of 70.7%. Closure failure was significantly correlated with more than four peritoneal lavage procedures, intestinal resection, and initial fascial defects greater than 7.5 cm. Primary indications for OA management were peritonitis/sepsis (34.8%) and bowel obstruction (19.6%).ConclusionsMesh-mediated fascial traction is effective for definitive abdominal wall closure in a majority of patients. However, identifying those at increased risk for closure failure is vital. Utilizing a tailored decision-making algorithm based on specific predictors can optimize clinical outcomes and reduce healthcare costs.
C1 [Ramirez-Giraldo, Camilo; Turizo, Jorge Luis; Isaza-Restrepo, Andres] Hosp Univ Mayor Mederi, Calle 24 29-45, Bogota, Colombia.
   [Ramirez-Giraldo, Camilo; Rincon-Nieto, Nicolas; Hernandez-Vesga, Julian; Turizo, Jorge Luis; Agudelo-Delgadillo, Daniel; Santamaria-Forero, Sofia; Isaza-Restrepo, Andres] Univ Rosario, Bogota, Colombia.
   [Pesce, Antonio] Univ Ferrara, Dept Surg, Azienda Un Sanit Locale Ferrara, Ferrara, Italy.
C3 Universidad del Rosario; University of Ferrara
RP Ramírez-Giraldo, C (通讯作者)，Hosp Univ Mayor Mederi, Calle 24 29-45, Bogota, Colombia.; Ramírez-Giraldo, C (通讯作者)，Univ Rosario, Bogota, Colombia.
EM ramirezgiraldocamilo@gmail.com; nicolas.rinconn@urosario.edu.co;
   julian.13andres@gmail.com; turizo0324@hotmail.com;
   antonio.pesce@unife.it; daniel.agudelod@gmail.com;
   ssantamariaf1@gmail.com; andres.isaza@urosario.edu.co
RI ; Ramírez-Giraldo, Camilo/LRV-0499-2024; PESCE, ANTONIO/G-4536-2017;
   Isaza-Restrepo, Andres/K-1790-2016
OI Santamaria- Forero, Sofia/0000-0002-0288-7915; Ramírez-Giraldo,
   Camilo/0000-0002-1929-2299; PESCE, ANTONIO/0000-0002-7560-551X;
   Hernández-Vesga, Julián/0000-0001-6010-6833; 
CR Acosta S, 2017, ANAESTH INTENSIVE TH, V49, P139, DOI 10.5603/AIT.a2017.0023
   Cirocchi R, 2016, J TRAUMA ACUTE CARE, V81, P575, DOI 10.1097/TA.0000000000001126
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   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0029-2
   Cristaudo AT, 2022, ANZ J SURG, V92, P1079, DOI 10.1111/ans.17512
   Fung S, 2022, LANGENBECK ARCH SURG, V407, P2075, DOI 10.1007/s00423-021-02424-1
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   Rashid R, 2024, INT J SURG, V110, P3151, DOI 10.1097/JS9.0000000000001268
   Rasilainen S, 2020, J TRAUMA ACUTE CARE, V89, P1136, DOI 10.1097/TA.0000000000002889
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
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   Willms AG, 2022, HERNIA, V26, P61, DOI 10.1007/s10029-020-02336-x
NR 24
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD OCT 16
PY 2025
VL 410
IS 1
AR 301
DI 10.1007/s00423-025-03871-w
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8QS3Q
UT WOS:001595060700003
PM 41099855
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Duncan, AJ
   Bartholomew, R
   Hopper, WA
   Zreik, K
   Dyke, C
   Ahmeti, M
AF Duncan, Anthony J.
   Bartholomew, Reid
   Hopper, Wade A.
   Zreik, Khaled
   Dyke, Cornelius
   Ahmeti, Mentor
TI Anastomotic Outcomes After Damage Control Laparotomy With Temporary
   Abdominal Closure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Bowel anastomosis; Negative pressure wound therapy; Open abdomen;
   Temporary abdominal closure
ID COLONIC INJURIES; OPEN ABDOMEN; TRAUMA; COMPLICATIONS; MANAGEMENT
AB Introduction: Negative pressure wound therapy (NPWT) is widely utilized to facilitate temporary abdominal closure following damage control laparotomy. The direct role of NPWT on anastomotic leak rates remains unclear. This study evaluates whether anastomotic exposure to NPWT is associated with increased risk for leak. Materials and methods: We performed a retrospective cohort study including all patients who underwent emergent exploratory laparotomy with temporary abdominal closure at our institution from 2013 to 2023. Patients were stratified based on whether or not they were treated with intra-abdominal NPWT applied in the setting of a newly created anastomosis. Results: Of 225 included patients, 93 (41%) received anastomotic exposure to NPWT. In multivariable regression, anastomotic NPWT exposure was not significantly associated with risk of leak. However, the Physiological Emergency Surgery Acuity Score (odds ratio: 1.359, P= 0.010) and days to fascial closure (odds ratio: 1.274, P< 0.001) were independent predictors of anastomotic leak. Conclusions: In patients undergoing damage control laparotomy, anastomotic NPWT exposure is not a clear independent risk factor for anastomotic leak and may be judiciously applied to bowel anastomoses when clinically indicated. The risk for leak appears to be more strongly associated with physiologic acuity and illness severity.<br /> (c) 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Duncan, Anthony J.; Bartholomew, Reid; Hopper, Wade A.; Zreik, Khaled; Dyke, Cornelius; Ahmeti, Mentor] Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, Fargo, ND USA.
   [Zreik, Khaled; Dyke, Cornelius; Ahmeti, Mentor] Sanford Med Ctr Fargo, Dept Trauma & Acute Care Surg, Fargo, ND USA.
   [Duncan, Anthony J.] Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, 1919 North Elm, Fargo, ND 58102 USA.
C3 University of North Dakota Grand Forks; Sanford Health; University of
   North Dakota Grand Forks
RP Duncan, AJ (通讯作者)，Univ North Dakota, Sch Med & Hlth Sci, Dept Surg, 1919 North Elm, Fargo, ND 58102 USA.
EM Anthony.duncan@und.edu
RI duncan, anthony/JTU-1888-2023
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUL
PY 2026
VL 323
BP 71
EP 76
DI 10.1016/j.jss.2026.04.001
EA MAY 2026
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HW8GN
UT WOS:001764568100001
PM 42092274
DA 2026-07-24
ER

PT J
AU Shishaeva, L
   Li, ZH
   Zuber, F
   Zulian, V
   Roduner, J
   Itel, F
   Ren, Q
AF Shishaeva, Liubov
   Li, Zhihao
   Zuber, Flavia
   Zulian, Vivian
   Roduner, Josua
   Itel, Fabian
   Ren, Qun
TI A simple and specific colorimetric biosensor for early detection of
   Pseudomonas aeruginosa wound infections
SO BIOSENSORS & BIOELECTRONICS
LA English
DT Article
DE Polyvinyl acetate sensor; Wound infections; P. aeruginosa biofilm;
   Negative pressure wound therapy
ID CYANIDE PRODUCTION; POLYVINYL-CHLORIDE; FLUORESCENS; POLYSTYRENE;
   ACETATE; BLENDS; SENSOR
AB Wound healing is a critical aspect of surgical care, often complicated by infections such as those caused by Pseudomonas aeruginosa (PA). In this study, we aim to develop a sensitive and specific colorimetric biosensor which allows early detection and naked-eye monitoring of PA wound infections. We used hydrogen cyanide (HCN) as a PA specific biomarker and aquacyanocobinamide (ACCbi), a vitamin B12 derivative, as the indicator which changes color from orange to violet upon interaction with HCN. We then encapsulated ACCbi with different electrospun fibers, including polyvinyl acetate (PVAc), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polycaprolactone (PCL), and polyurethane (PU), and evaluated them for suitability as ACCbi carriers. The morphology of the fabricated membranes was analyzed using scanning electron microscopy (SEM). The performance of the materials was assessed for their structural integrity, sensitivity and sensor function. PVAc based membranes demonstrated the best stability and sensitivity, maintaining structural integrity and showing a distinct color change in response to HCN. In a real-world setup of negative pressure wound therapy, the optimized PVAc membranes exhibited a clear color change within 10 h of exposure to PA biofilms formed in vitro and within 12 h to that on ex vivo human skin wounds. The biosensor retained its functionality after two years of storage, offering a promising tool for the early PA detection in clinical wound care.
C1 [Shishaeva, Liubov; Li, Zhihao; Zuber, Flavia; Roduner, Josua; Ren, Qun] Swiss Fed Labs Mat Sci & Technol, Empa, Lab Biointerfaces, CH-9014 St Gallen, Switzerland.
   [Zulian, Vivian] Univ Zurich, Fac Med, CH-8032 Zurich, Switzerland.
   [Itel, Fabian] Swiss Fed Labs Mat Sci & Technol, Lab Biomimet Membranes & Text, Empa, CH-9014 St Gallen, Switzerland.
   [Li, Zhihao] Mayo Clin, William J Liebig Transplant Ctr, Div Transplant Surg, Rochester, MN 55905 USA.
   [Itel, Fabian] Sefar AG, CH-9410 Heiden, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; Swiss Federal
   Laboratories for Materials Science & Technology (EMPA); University of
   Geneva; University of Zurich; Swiss Federal Institutes of Technology
   Domain; Swiss Federal Laboratories for Materials Science & Technology
   (EMPA); Mayo Clinic
RP Li, ZH; Ren, Q (通讯作者)，Swiss Fed Labs Mat Sci & Technol, Empa, Lab Biointerfaces, CH-9014 St Gallen, Switzerland.; Li, ZH (通讯作者)，Mayo Clin, William J Liebig Transplant Ctr, Div Transplant Surg, Rochester, MN 55905 USA.
EM zhihaoli91@gmail.com; Qun.Ren@empa.ch
RI Ren, Qun/A-3532-2016; Itel, Fabian/AAU-2465-2021
OI Ren, Qun/0000-0003-0627-761X; Li, Zhihao/0000-0002-5654-7043; Itel,
   Fabian/0000-0002-4161-2383
FU Swiss National Science Foundation [310031_197617/1]
FX The authors would like to express their gratitude to Rossella Acampora
   and Sixuan Zhang for their assistance with sensor assays, and to
   Professor Jorg Grunert for providing ex-vivo human skin samples. Special
   thanks to Gerhard Eich and Benjamin Preiswerk from Triemli Hospital for
   providing the clinical PA isolates, Jorg Gschwend for his assistance
   with V.A.C. canister adjustments This work was supported by the Swiss
   National Science Foundation (grant No. 310031_197617/1) awarded to Q.R.
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NR 44
TC 4
Z9 4
U1 3
U2 15
PU ELSEVIER ADVANCED TECHNOLOGY
PI OXFORD
PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON,
   OXFORD OX5 1GB, OXON, ENGLAND
SN 0956-5663
EI 1873-4235
J9 BIOSENS BIOELECTRON
JI Biosens. Bioelectron.
PD NOV 1
PY 2025
VL 287
AR 117698
DI 10.1016/j.bios.2025.117698
EA JUN 2025
PG 9
WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical;
   Electrochemistry; Nanoscience & Nanotechnology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Biotechnology & Applied Microbiology; Chemistry;
   Electrochemistry; Science & Technology - Other Topics
GA 4IV6V
UT WOS:001519055800002
PM 40543172
OA Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Png, ME
   Madan, JJ
   Dritsaki, M
   Achten, J
   Parsons, N
   Fernandez, M
   Grant, R
   Nanchahal, J
   Costa, ML
AF Png, M. E.
   Madan, J. J.
   Dritsaki, M.
   Achten, J.
   Parsons, N.
   Fernandez, M.
   Grant, R.
   Nanchahal, J.
   Costa, M. L.
CA WHiST Trial Collaborators
TI Cost-utility analysis of standard dressing compared with incisional
   negative-pressure wound therapy among patients with closed surgical
   wounds following major trauma to the lower limb
SO BONE & JOINT JOURNAL
LA English
DT Article
AB Aims
   To compare the cost-utility of standard dressing with incisional negative-pressure wound therapy (iNPWT) in adults with closed surgical wounds associated with major trauma to the lower limbs.
   Methods
   A within-trial economic evaluation was conducted from the UK NHS and personal social services (PSS) perspective based on data collected from the Wound Healing in Surgery for Trauma (WHiST) multicentre randomized clinical trial. Health resource utilization was collected over a six-month post-randomization period using trial case report forms and participant-completed questionnaires. Cost-utility was reported in terms of incremental cost per quality-adjusted life year (QALY) gained. Sensitivity analysis was conducted to test the robustness of cost-effectiveness estimates while uncertainty was handled using confidence ellipses and cost-effectiveness acceptability curves.
   Results
   The incremental cost of standard dressing versus iNPWT over six months was 2,037 pound (95% confidence interval (CI) 349 pound to 3,724) pound. There was an insignificant increment in QALYs gained in the iNPWT group (0.005, 95% CI -0.018 to 0.028). The probability of iNPWT being cost-effective at 20,000 pound per QALY was 1.9%. The results remained robust in the sensitivity analysis.
   Conclusion
   The within-trial economic evaluation suggests that iNPWT is unlikely to be a cost-effective alternative to standard dressing in adults with closed surgical wounds to their lower limbs.
C1 [Png, M. E.] Univ Oxford, Hlth Econ, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
   [Png, M. E.; Dritsaki, M.; Achten, J.; Fernandez, M.; Nanchahal, J.; Costa, M. L.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Madan, J. J.; Parsons, N.; Grant, R.] Univ Oxford, Oxford, England.
   [Madan, J. J.; Parsons, N.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol, Coventry, W Midlands, England.
   [Grant, R.] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Oxford;
   University of Warwick; University of Warwick
RP Png, ME (通讯作者)，Univ Oxford, Hlth Econ, Nuffield Dept Primary Care Hlth Sci, Oxford, England.; Png, ME (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
EM may.png@phc.ox.ac.uk
RI ; Achten, Juul/KUD-8515-2024; Png, May Ee/AAG-4902-2019; Parsons,
   Nick/AAA-8713-2019
OI Madan, Jason/0000-0003-4316-1480; Achten, Juul/0000-0002-8857-5743;
   Nanchahal, Jagdeep/0000-0002-9579-9411; Costa,
   Matthew/0000-0003-3644-1388; Png, May Ee/0000-0001-5876-9363; Parsons,
   Nick/0000-0001-9975-888X
FU UK National Institute for Health Research Health Technology Assessment
   (HTA) Programme; National Institute for Health Research (NIHR) Oxford
   Biomedical Research Centre; National Institute for Health Research
   [14/199/14] Funding Source: researchfish
FX Although none of the authors has received or will receive benefits for
   personal or professional use from a commercial party related directly or
   indirectly to the subject of this article, benefits have been or will be
   received but will be directed solely to a research fund, foundation,
   educational institution, or other non-profit organization with which one
   or more of the authors are associated. This project was funded by the UK
   National Institute for Health Research Health Technology Assessment
   (HTA) Programme and was supported by the National Institute for Health
   Research (NIHR) Oxford Biomedical Research Centre. The funder has not
   been involved in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data, the preparation,
   review, or approval of the manuscript, nor in the decision to submit the
   manuscript for publication. The views expressed are those of the authors
   and not necessarily those of the NHS, the NIHR or the Department of
   Health. Smith & Nephew provided incisional NPWT dressings (PICO Single
   Use Negative Pressure Wound Therapy System) to recruiting centres for
   the purposes of the trial and had no part in the design, conduct or
   reporting of the study.
CR Achten J, 2018, BMJ OPEN, V8
   [Anonymous], 2018, EMPL EARN UK
   [Anonymous], 2020, DDD INDEX 2020
   Claxton K, 2015, HEALTH TECHNOL ASSES, V19, P1, DOI 10.3310/hta19140
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   Drummond MichaelF., 2002, Methods for the Economic Evaluation of Health Care Programmes
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   Herdman M, 2011, QUAL LIFE RES, V20, P1727, DOI 10.1007/s11136-011-9903-x
   Hyldig N, 2016, BJS-BRIT J SURG, V103, P477, DOI 10.1002/bjs.10084
   McCabe C, 2008, PHARMACOECONOMICS, V26, P733, DOI 10.2165/00019053-200826090-00004
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   Young M J, 1994, Orthop Rev, V23, P149
NR 16
TC 14
Z9 15
U1 0
U2 5
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD AUG
PY 2020
VL 102B
IS 8
BP 1072
EP 1081
DI 10.1302/0301-620X.102B8.BJJ-2020-0126.R1
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ND4MO
UT WOS:000561876000014
PM 32731829
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Pereima, MJL
   Feijó, R
   da Gama, FO
   Boccardi, RD
AF Lopes Pereima, Mauricio Jose
   Feijo, Rodrigo
   da Gama, Fabiana Oenning
   Boccardi, Roberto de Oliveira
TI Treatment of burned children using dermal regeneration template with or
   without negative pressure
SO BURNS
LA English
DT Article
DE Wound healing; Burns; Negative-pressure wound therapy; Child
ID PEDIATRIC BURNS; WOUND THERAPY; RECONSTRUCTION; MANAGEMENT; INTEGRA;
   EPIDEMIOLOGY
AB Objective: Evaluate the results obtained using a Dermal Regeneration Template (DRT) associated or not with the Negative Pressure Wound Therapy (NPWT) for skin cover in paediatric patients who were victims of burns.
   Method: Retrospective study of a cross-sectional study that evaluated the medical records of children submitted to the application of DRT, associated or not with NPWT, for the treatment of burned children admitted to the Joana de Gusmao Children's Hospital (JGCH) in FlorianOpolis, in the period from January 2011 to December 2016, totalling 45 patients.
   Results: The majority of the patients were pubescent (31.8%) males (56.8%), and the main aetiology of the burn was flammable substances (75%). In the group that used only DRT, the average take of DRT was 85% with an average time of maturity of 17.65 days and the mean take rate of the skin graft was 85.2%. In the group that used DRT plus NPWT, the mean DRT take was 99.8%, with a mean maturation time of 16.68 days and the mean of the skin graft take rate was 89.1%.
   Conclusion: NPWT associated with DRT offers a higher rate of success in the treatment of complex wounds caused by burns, promotes increased DRT take rate, reduces DRT maturation time and increases the take rate of the skin graft. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
C1 [Lopes Pereima, Mauricio Jose] Univ Fed Santa Catarina, Joana de Gusmao Children Hosp, Burn Trauma Ctr, Dept Pediat, Florianopolis, SC, Brazil.
   [Feijo, Rodrigo] Joana de Gusmao Children Hosp, Burn Trauma Ctr, Florianopolis, SC, Brazil.
   [da Gama, Fabiana Oenning; Boccardi, Roberto de Oliveira] Univ Sul Santa Catarina, UNISUL, Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade do Sul de
   Santa Catarina
RP Pereima, MJL (通讯作者)，Desembargador Pedro Silva 1952,Apartamento 502-2, BR-88080720 Florianopolis, SC, Brazil.
EM mauricio.pereima@ufsc.br
CR Alaghehbandan R, 2012, BURNS, V38, P136, DOI 10.1016/j.burns.2011.06.010
   Bartosch I, 2013, BURNS, V39, P477, DOI 10.1016/j.burns.2012.07.023
   Bloemen MCT, 2009, BURNS, V35, P463, DOI 10.1016/j.burns.2008.07.016
   Bovill E, 2008, INT WOUND J, V5, P511, DOI 10.1111/j.1742-481X.2008.00437.x
   Cruz BF, 2012, REV BRAS QUEIMADURAS, V11, P246
   De Young AC, 2012, J CHILD PSYCHOL PSYC, V53, P56, DOI 10.1111/j.1469-7610.2011.02431.x
   Duci SB, 2014, BURNS, V40, P1789, DOI 10.1016/j.burns.2014.04.002
   Duffy BJ, 2006, CLIN PEDIATR EMERG M, V7, P82, DOI 10.1016/j.cpem.2006.04.001
   DUMVILLE JC, 2012, COCHRANE DATABASE SY
   Goulart BC, 2010, REV BRAS QUEIMADURAS, V9, P124
   Graf A, 2011, J PEDIATR PSYCHOL, V36, P923, DOI 10.1093/jpepsy/jsr021
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Groos N, 2005, EUR J PEDIATR SURG, V15, P187, DOI 10.1055/s-2004-821215
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Lund CC., 1944, SURG GYNECOLOGY OBST, V79, P352
   Machado THS, 2009, REV BRAS QUEIMADURAS, V8, P3
   Maes NB, 2012, REV BRAS QUEIMADURAS, V11, P6
   Marcondes E., 2002, PEDIAT BASICA
   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
   Muangman P, 2006, ANN PLAS SURG, V57, P199, DOI 10.1097/01.sap.0000218636.61803.d6
   Olawoye OA, 2014, BURNS, V40, P1794, DOI 10.1016/j.burns.2014.04.008
   Park CA, 2009, ANN PLAS SURG, V62, P164, DOI 10.1097/SAP.0b013e31817d87cb
   Peck MD, 2011, BURNS, V37, P1087, DOI 10.1016/j.burns.2011.06.005
   Peden M, 2008, BURN WORLD REPORT CH, P79
   Pereima MJ, 2009, REV BRAS QUEIMADURAS, V8, P51
   Rowan M, 2015, J CHILD PSYCHOL PSYC, V19
   Schiestl C, 2013, EUR J PEDIATR SURG, V23, P341, DOI 10.1055/s-0033-1356650
   SHERIDAN RL, 1994, EUR J PLAST SURG, V17, P91
   Sobouti B, 2013, BURNS, V39, P473, DOI 10.1016/j.burns.2012.08.010
   Spinks A, 2008, J BURN CARE RES, V29, P482, DOI 10.1097/BCR.0b013e3181776ed9
   Wunderlich B, 2011, REV BRAS QUEIMADURAS, V10, P78
   Xu JH, 2014, BURNS, V40, P1780, DOI 10.1016/j.burns.2014.04.003
NR 33
TC 10
Z9 13
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD AUG
PY 2019
VL 45
IS 5
BP 1075
EP 1080
DI 10.1016/j.burns.2018.08.009
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Dermatology; Surgery
GA IC3JK
UT WOS:000470856100009
PM 31113686
DA 2026-07-24
ER

PT J
AU De Donder, L
   Uyttebroek, O
   Van Cleven, S
   Berrevoet, F
AF De Donder, Laura
   Uyttebroek, Ortwin
   Van Cleven, Stijn
   Berrevoet, Frederik
TI A subcutaneous infection mimicking necrotizing fasciitis due to
   Butyricimonas virosa
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Butyricimonas; anaerobes; necrotizing fasciitis; negative pressure wound
   therapy; LRINEC
ID SP NOV.; BACTEREMIA
AB Introduction: Butyricimonas virosa is a Gram-negative rod who was first identified in rat faces in 2009. Since then only six human infections have been described in literature of which five bacteremia and one bone abscess. We report a clinical case of a subcutaneous infection mimicking necrotizing fasciitis due to B. virosa. Patient and methods: A 78-year-old man was referred to our hospital because of a wound infection at the surgical site with suspicion of necrotizing fasciitis. Treatment consisted of immediate surgical exploration with obtainment of intra-operative specimens for microbiologic examination, 15 d of negative pressure wound therapy (NPWT) and antibiotic treatment with piperacillin-tazobactam (12 d) plus vancomycin (9 d). Results: Surgical exploration did not show necrotising fasciitis but a subcutaneous infection mimicking necrotising fasciitis. The results of the intra-operative specimens revealed the presence of B.virosa and Finegoldia magna. Cultures taken during the NPWT replacements became negative and the patient was able to leave the hospital after 18 d. Conclusions: Considering there was no necrotizing infection present it may have been possible to safely close the wound sooner. However, it is difficult to differentiate between an actual necrotizing fasciitis and a subcutaneous infection mimicking necrotizing fasciitis. Therefore further studies on effective assessment tools to diagnose necrotizing fasciitis, such as the (modified) laboratory risk indicator for necrotizing fasciitis (LRINEC) score and enhanced computed tomography (CT), could be helpful.
C1 [De Donder, Laura] Univ Ghent, Ghent, Belgium.
   [Uyttebroek, Ortwin; Van Cleven, Stijn; Berrevoet, Frederik] Ghent Univ Hosp, Dept Gen & HPB Surg, Ghent, Belgium.
C3 Ghent University; Ghent University; Ghent University Hospital
RP De Donder, L (通讯作者)，Univ Ghent, Ghent, Belgium.
EM laura.dedonder@ugent.be
RI Berrevoet, Frederik/A-6117-2008
CR Bechar J, 2017, ANN ROY COLL SURG, V99, P341, DOI 10.1308/rcsann.2017.0053
   Boyanova L, 2016, ANAEROBE, V42, P145, DOI 10.1016/j.anaerobe.2016.10.007
   Enemchukwu C. U., 2016, New Microbes and New Infections, V13, P34, DOI [10.1016/j.nmni.2016.05.004, 10.1016/j.nmni.2016.05.004]
   Ferry T, 2015, BMJ CASE REP, V2015
   García-Agudo L, 2018, ANAEROBE, V54, P121, DOI 10.1016/j.anaerobe.2018.08.001
   Le Roy T, 2019, INT J SYST EVOL MICR, V69, P833, DOI 10.1099/ijsem.0.003249
   Mehta S R, 2015, New Microbes New Infect, V8, P127, DOI [10.1016/j.nmni.2015.10.011, 10.1016/j.nmni.2015.10.011]
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   Sakamoto M, 2014, INT J SYST EVOL MICR, V64, P2992, DOI 10.1099/ijs.0.065318-0
   Sakamoto M, 2009, INT J SYST EVOL MICR, V59, P1748, DOI 10.1099/ijs.0.007674-0
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   Togo A. H., 2016, New Microbes and New Infections, V14, P38, DOI 10.1016/j.nmni.2016.07.010
   Toprak N. Ulger, 2015, New Microbes and New Infections, V4, P7, DOI [10.1016/j.nmni.2014.12.004, 10.1016/j.nmni.2014.12.004]
NR 13
TC 8
Z9 8
U1 1
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
EI 2577-0160
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD NOV 1
PY 2020
VL 120
IS 6
BP 425
EP 428
DI 10.1080/00015458.2019.1631612
EA JUN 2019
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OK6XN
UT WOS:000472981000001
PM 31203733
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Sabatakakis, A
   Fenske, J
   Lampert, P
   Kreiker, H
   Steffen, C
   Koerdt, S
   Doll, C
   Kreutzer, K
   Heiland, M
   Rendenbach, C
AF Sabatakakis, Antonis
   Fenske, Jakob
   Lampert, Philipp
   Kreiker, Henri
   Steffen, Claudius
   Koerdt, Steffen
   Doll, Christian
   Kreutzer, Kilian
   Heiland, Max
   Rendenbach, Carsten
TI Towards optimized donor site closure of radial forearm flaps: A cohort
   study of two techniques
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Free flap surgery; Radial forearm free flap; Maxillofacial
   reconstruction; Donor site complications; Tendon exposure; Negative
   pressure wound therapy
ID SKIN-GRAFT; NECK RECONSTRUCTION; MORBIDITY; HEAD
AB The radial forearm flap (RFF) is widely used for microvascular reconstruction in the head and neck region, but donor site complications, such as flexor tendon exposure, can impact patient recovery. This study retrospectively analyzed all patients who underwent RFF surgery between April 2017 and July 2023 to identify risk factors for donor site complications and compare the efficacy of two full-thickness skin graft (FTSG) designs: semilunar and VY/Dagger shaped. A matched-pair analysis was performed, and uni-and multivariate analyses were conducted to assess complication risks. Among 401 patients (178 females, mean age 67 +/- 12.4 years), 35 % experienced donor site complications. The semilunar FTSG design was identified as a predictor for flexor tendon exposure in both general (p = 0.03) and matched-pair analysis (p = 0.005). Negative pressure wound therapy (NPWT) did not demonstrate superior outcomes compared to conventional methods and was associated with an increased risk of partial graft necrosis (p = 0.03). These findings highlight the importance of FTSG design in RFF donor site closure, with the VY/Dagger shape demonstrating superior outcomes in reducing tendon exposure. Additionally, NPWT does not appear to provide significant benefits in preventing local complications and may not be preferable to conventional wound dressings. These results underscore the role of reflective surgical practice in improving patient outcomes.
C1 [Fenske, Jakob] Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
   Free Univ Berlin, Berlin, Germany.
   Humboldt Univ, Dept Oral & Maxillofacial Surg, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin
RP Fenske, J (通讯作者)，Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM jakob.fenske@charite.de
RI Fenske, Jakob/LLM-2561-2024; Rendenbach, Carsten/E-8384-2013; Heiland,
   Max/IUM-8981-2023; Steffen, Claudius/AAS-6626-2021; Doll,
   Christian/QMQ-3496-2026
OI Fenske, Jakob/0009-0000-3453-3903; Kreutzer, Kilian/0000-0003-0581-4137;
   Rendenbach, Carsten/0000-0002-9565-7640; Koerdt,
   Steffen/0000-0002-8679-8775; Heiland, Max/0000-0002-4987-2913; Kreiker,
   Henri/0000-0003-1935-3546; Steffen, Claudius/0000-0003-4221-4878;
   Lampert, Philipp/0009-0005-9392-728X
FU German Research Foundation (DFG) [RE 4803/1-1]
FX This research was funded by the German Research Foundation (DFG, RE
   4803/1-1) .
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NR 32
TC 1
Z9 1
U1 0
U2 0
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD AUG
PY 2025
VL 53
IS 8
BP 1123
EP 1128
DI 10.1016/j.jcms.2025.04.005
EA AUG 2025
PG 6
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 5FY6D
UT WOS:001534762200002
PM 40324917
OA hybrid
DA 2026-07-24
ER

PT J
AU Li, ST
   Nong, QW
   Wu, YJ
   Liu, D
AF Li, Shuntang
   Nong, Qingwen
   Wu, Yajun
   Liu, Daen
TI Healing an ischial tuberosity pressure ulcer in a patient with
   neurogenic heterotopic ossification: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hip; negative pressure wound therapy; neurogenic heterotopic
   ossification; pressure ulcer; spinal cord injury; wound; wound care;
   wound healing
ID SPINAL-CORD-INJURY; MYOCUTANEOUS FLAP; RECONSTRUCTION; MANAGEMENT
AB Neurogenic heterotopic ossification (NHO) is widely recognised as an aberrant bone formation in soft tissue following central nervous system injury. It is most frequently associated with pain and limited movement, especially in the hip. However, it may be neglected in patients with paraplegia with a pressure ulcer (PU). We report the case of an 18-year-old male patient who presented with a hard-to-heal ischial tuberosity PU and who had undergone three operations at other hospitals during the previous six months, which had failed to repair the PU. There was a history of paraplegia as a consequence of spinal cord injury two years previously. Computed tomography and three-dimensional reconstruction showed massive heterotopic ossification (HO) in the wound bed and around the right hip. Histological findings were consistent with a diagnosis of HO. The HO around the wound was completely excised, negative pressure wound therapy was used to promote granulation, and a gluteus maximus musculocutaneous flap was used to cover the wound. We conclude that for patients with paraplegia, with a hard-to-heal PU, it should be determined whether it is associated with NHO. Surgical resection of HO surrounding the wound and improving the microcirculation are critical for repair and reconstruction of these PUs.
C1 [Li, Shuntang; Nong, Qingwen; Wu, Yajun; Liu, Daen] Guangxi Med Univ, Dept Burns & Plast Surg, Affiliate Hosp 1, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University
RP Li, ST (通讯作者)，Guangxi Med Univ, Dept Burns & Plast Surg, Affiliate Hosp 1, Nanning 530021, Guangxi, Peoples R China.
EM 0504410155@163.com
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NR 27
TC 0
Z9 0
U1 5
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
SU 3A
BP LXIX
EP LXXIII
DI 10.12968/jowc.2024.33.Sup3a.lxix
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ON8J2
UT WOS:001208042300003
PM 38457272
DA 2026-07-24
ER

PT J
AU Bashyal, RK
   Searle, R
   Nherera, LM
   Wright, A
AF Bashyal, Ravi K.
   Searle, Richard
   Nherera, Leo M.
   Wright, Adam
TI Effects of single-use negative pressure wound therapy on healthcare use:
   US analysis of a large claims database
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE cardiovascular; healthcare resource use; negative pressure wound
   therapy; orthopaedic; surgical site complications; wound; wound care;
   wound dressing; wound healing
ID INFECTIONS; METAANALYSIS; DEHISCENCE; PREDICTORS; COSTS
AB Objective: To assess the effect of two single-use negative pressure and surgical site complications (SSCs) after orthopaedic and cardiovascular surgery. Method: Patient data were collected from the US-based Premier Adult patients upon whom the -80mmHg or -125mmHg sNPWT device was used within predefined orthopaedic and cardiovascular surgical categories were included. The HCRU endpoints measured were index encounter length of stay (LoS), and cost at index encounter and at 30 and 90 days post-surgery. Clinical endpoints were also assessed. Results: The mean index encounter LoS, and mean cost at index admission and at 30 and 90 days post-surgery were all significantly lower when the -80mmHg device was used, compared with the -125mmHg device, across orthopaedic and cardiovascular wounds (all p<0.0001). The odds ratio (OR) for dehiscence (30 days) was significantly lower when the-80mmHg device was used versus the-125mmHg device in orthopaedic (OR: 0.361; p <= 0.05) and cardiovascular (OR: 0.422; p <= 0.01) wounds. Differences between the devices were not found in superficial and deep surgical site infections or seroma for either orthopaedic or cardiovascular incisions (p>0.05). Conclusion: The-80mmHg device was associated with significantly lower HCRU and likelihood of dehiscence after orthopaedic and cardiovascular surgery versus the-125mmHg device and there were no differences in other SSCs.
C1 [Bashyal, Ravi K.] Endeavor Hlth Orthoped Inst, Skokie, IL USA.
   [Searle, Richard; Nherera, Leo M.] Smith Nephew Inc, Global Hlth Econ & Outcomes Res, Data Analyt, Ft Worth, TX 76107 USA.
   [Wright, Adam] Plano Orthoped & Sports Med Ctr, Plano, TX USA.
C3 Smith & Nephew
RP Nherera, LM (通讯作者)，Smith Nephew Inc, Global Hlth Econ & Outcomes Res, Data Analyt, Ft Worth, TX 76107 USA.
EM Leo.Nherera@smith-nephew.com
FU Smith+Nephew, Inc.
FX The authors would like to thank Francesca Lewns and Maike Jager of
   Costello Medical, UK for medical writing support funded by Smith+Nephew,
   Inc. They also want to thank Julie Murdoch and Amanda Spitzer of
   Smith+Nephew, Inc. for interpreting the clinical surgical complication
   results.
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NR 53
TC 1
Z9 1
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2025
VL 34
IS 8
BP 555
EP 562
DI 10.12968/jowc.2024.0339
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6DQ3V
UT WOS:001550856500001
PM 40801766
DA 2026-07-24
ER

PT J
AU Meyer, J
   Roos, E
   Abbassi, Z
   Toso, C
   Ris, F
   Buchs, NC
AF Meyer, Jeremy
   Roos, Elin
   Abbassi, Ziad
   Toso, Christian
   Ris, Frederic
   Buchs, Nicolas C.
TI The role of perineal application of prophylactic negative-pressure wound
   therapy for prevention of wound-related complications after
   abdomino-perineal resection: a systematic review
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Review
DE Abdomino-perineal amputation; Abdomino-perineal resection; Colorectal
   cancer; Rectal cancer; Infection; Perineal infection
ID RECTAL-CANCER; PELVIC FLOOR; RECONSTRUCTION; MANAGEMENT; EXCISION;
   CLOSURE
AB Background Closed perineal wounds often fail to heal by primary intention after abdomino-perineal resection (APR) and are often complicated by surgical site infection (SSI) and/or wound dehiscence. Recent evidence showed encouraging results of prophylactic negative-pressure wound therapy (pNPWT) for prevention of wound-related complications in surgery. Our objective was to gather and discuss the early existing literature regarding the use of pNPWT to prevent wound-related complications on perineal wounds after APR. Methods Medline, Embase, and Web of Science were searched for original publications and congress abstracts reporting the use of pNPWT after APR on closed perineal wounds. Results Seven publications were included for analysis. Two publications reported significantly lower incidence of SSI in pNPWT patients than in controls with a risk reduction of about 25-30%. Two other publications described similar incidences of SSI between the two groups of patients but described SSI in pNPWT patients to be less severe. One study reported significantly lower incidence of wound dehiscence in pNPWT patients than in controls. Conclusion The largest non-randomized studies investigating the effect of pNPWT on the prevention of wound-related complications after APR showed encouraging results in terms of reduction of SSI and wound dehiscence that deserve further investigation and confirmation.
C1 [Meyer, Jeremy; Abbassi, Ziad; Toso, Christian; Ris, Frederic; Buchs, Nicolas C.] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Roos, Elin] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 University of Geneva; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Toso, Christian/E-7785-2018; Meyer, Jeremy/AAP-3367-2020; Abbassi,
   Ziad/HZL-6239-2023; Ris, Frederic/H-7030-2019
OI Toso, Christian/0000-0003-1652-4522; Meyer, Jeremy/0000-0003-3381-9146;
   Abbassi, Ziad/0000-0002-4130-5084; Ris, Frederic/0000-0001-7421-6101
FU University of Geneva
FX Open access funding provided by University of Geneva.
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NR 20
TC 18
Z9 21
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JAN
PY 2021
VL 36
IS 1
BP 19
EP 26
DI 10.1007/s00384-020-03732-6
EA SEP 2020
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA PO1YK
UT WOS:000566084400001
PM 32886194
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Weréen, A
   Dahlberg, M
   Heinius, G
   Pieniowski, E
   Saraste, D
   Eklöv, K
   Nygren, J
   Pekkari, K
   Everhov, ÅH
AF Wereen, Alice
   Dahlberg, Martin
   Heinius, Goeran
   Pieniowski, Emil
   Saraste, Deborah
   Eklov, Karolina
   Nygren, Jonas
   Pekkari, Klas
   Everhov, Asa H.
TI Long-Term Results after Anastomotic Leakage following Rectal Cancer
   Surgery: A Comparison of Treatment with Endo-Sponge and Transanal
   Irrigation
SO DIGESTIVE SURGERY
LA English
DT Article
DE Rectal neoplasm; Anastomotic leak; Surgical sponge; Endo-SPONGE;
   Endoscopic vacuum-assisted closure; TME
ID LOW ANTERIOR RESECTION; ENDOSCOPIC VACUUM THERAPY; ASSISTED CLOSURE;
   DRAINAGE; MANAGEMENT; EXPERIENCE; EFFICACY; ETVARD; STOMA; RISK
AB Objective: We aimed to evaluate long-term results in patients from regular health care treated with endoscopic transanal closure system, that is, endoscopic vacuum-assisted closure system (EVAC) compared to transanal irrigation. Methods: In this retrospective, medical chart-based, observational study, we included patients with anastomotic leakage after low anterior resection for rectal cancer from 3 Stockholm hospitals 2006-2016 and compared time to first stoma closure in a Kaplan-Meier model and the proportion of patients who were stoma-free at end of follow-up. Results: Anastomotic leakage was found in 81 patients who were followed up in median 5.9 years (min-max: 0.53-13). EVAC was used on 14 (17%) patients and transanal irrigation on 34 (42%) patients. The remaining 33 (41%) patients either got a permanent colostomy or were treated only with antibiotics and percutaneous drainage. Treatment with EVAC or transanal irrigation led to similar rates of stoma closure, both when comparing all patients, and when comparing patients with similar defects. At the end of follow-up, 43% of patients treated with EVAC and 50% of patients treated with repeated irrigation were stoma-free (p = 0.75). Conclusions: We found no evidence of better outcomes in patients treated with EVAC. The study was, however, limited by small sample size.
C1 [Wereen, Alice; Dahlberg, Martin; Heinius, Goeran; Eklov, Karolina; Everhov, Asa H.] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
   [Pieniowski, Emil; Saraste, Deborah] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Nygren, Jonas; Pekkari, Klas] Karolinska Inst, Ersta Hosp, Dept Surg, Stockholm, Sweden.
   [Nygren, Jonas; Pekkari, Klas] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
   [Everhov, Asa H.] Karolinska Inst, Clin Epidemiol Div, Dept Med Solna, Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Karolinska Institutet;
   Karolinska Institutet; Ersta Sjukhus; Karolinska Institutet; Danderyds
   Hospital; Karolinska Institutet
RP Everhov, ÅH (通讯作者)，Stockholm South Gen Hosp, Dept Surg, SE-11861 Stockholm, Sweden.
EM asa.hallqvist-everhov@ki.se
RI Everhov, Åsa H/E-4399-2018; Pekkari, Klas/AAA-5124-2022; Nygren,
   Jonas/AAQ-2775-2021; Saraste, Deborah/ACE-2715-2022
OI Everhov, Åsa H/0000-0002-0311-8894; Saraste,
   Deborah/0000-0002-2931-2652; 
FU Karolinska Institutet, Bengt Ihre Foundation; Bengt Ihre Research
   Fellowship
FX This project was funded by Karolinska Institutet, Bengt Ihre Foundation,
   and the Bengt Ihre Research Fellowship.
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NR 24
TC 12
Z9 12
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-4886
EI 1421-9883
J9 DIGEST SURG
JI Dig. Surg.
PD NOV
PY 2020
VL 37
IS 6
BP 456
EP 462
DI 10.1159/000508935
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA OT9RD
UT WOS:000591173500003
PM 32829324
DA 2026-07-24
ER

PT J
AU Campbell, AM
   Kuhn, WP
   Barker, P
AF Campbell, A. M.
   Kuhn, W. P.
   Barker, P.
TI Vacuum-assisted closure of the open abdomen in a resource-limited
   setting
SO SOUTH AFRICAN JOURNAL OF SURGERY
LA English
DT Article
ID PACK TECHNIQUE; WOUNDS; TRAUMA
AB Aim. We describe our experience of developing a modified vacuum-assisted closure (VAC) dressing for open abdomens.
   Background. We see a high volume of trauma in our department. Massive delays in presentation of patients with acute abdomen are common. Closure at initial laparotomy is not possible in many cases, either because the patient has or will develop abdominal compartment syndrome, or because several re-look laparotomies will be required. A significant proportion of our patients who have undergone laparotomy therefore spend some of their stay in hospital with an open abdomen. The management of these patients is particularly labour intensive for nursing staff. The Opsite sandwich or Bogota bag invariably leaks, and sometimes needs changing daily. If a patient also has a temporary ileostomy, application can be difficult. The commercial VAC dressing is an improvement on the Opsite sandwich, but is prohibitively expensive. Financial constraints and the volume of abdominal trauma and sepsis we see mean that commercial VAC dressings for laparostomy are not affordable in our setting.
   Methods/results: We describe our adapted VAC dressing. It is inexpensive and easy to apply, has made a big difference in the nursing of patients with an open abdomen, and has enabled us to increase the rate of delayed primary closure (i.e. we have reduced the rate of ventral hernia).
   Conclusion. The modified VAC dressing is now our department's method of choice for temporary abdominal closure.
C1 [Campbell, A. M.; Kuhn, W. P.; Barker, P.] Ngwelezane Hosp, Kwazulu Natal, South Korea.
RP Campbell, AM (通讯作者)，Ngwelezane Hosp, Kwazulu Natal, South Korea.
OI Campbell, Alison/0009-0005-5951-8028
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Fernandez L, 1996, J TRAUMA, V40, P258, DOI 10.1097/00005373-199602000-00014
   Garner GB, 2001, AM J SURG, V182, P630, DOI 10.1016/S0002-9610(01)00786-3
   Ghimenton F, 2000, BRIT J SURG, V87, P106, DOI 10.1046/j.1365-2168.2000.01337.x
   Lee JC, 2006, CURR OPIN CRIT CARE, V12, P346, DOI 10.1097/01.ccx.0000235213.63988.9a
   MOENG S, 2005, INT TRAUMA CARE  FAL, P185
   Moore EE, 1998, WORLD J SURG, V22, P1184, DOI 10.1007/s002689900542
   Navsaria PH, 2003, BRIT J SURG, V90, P718, DOI 10.1002/bjs.4101
   Ogilvie WH, 1940, LANCET, V2, P253
NR 9
TC 10
Z9 11
U1 0
U2 0
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0038-2361
J9 S AFR J SURG
JI South Afr. J. Surg.
PD NOV
PY 2010
VL 48
IS 4
BP 114
EP 115
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 717AP
UT WOS:000287014900003
PM 21542399
DA 2026-07-24
ER

PT J
AU Stiefel, D
   Schiestl, CM
   Meuli, M
AF Stiefel, Dorothea
   Schiestl, Clemens M.
   Meuli, Martin
TI The positive effect of negative pressure: vacuum-assisted fixation of
   Integra artificial skin for reconstructive surgery
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure system; Negative pressure; Reconstructive
   surgery; Pediatric patients; Integra artificial skin; Skin substitute
ID DRESSINGS; DERMIS
AB Background: Integra artificial skin (Integra) (Integra Life Sciences Corporation, Plainsboro, NJ) is increasingly used as a skin substitute in reconstructive surgery. However, reliable fixation to the wound bed, a factor of paramount importance for successful application, is often hard to achieve. The vacuum-assisted closure system (VAC; KCl, Switzerland), a well-established subatmospheric pressure device, might be of interest to overcome these problems because of its ability to conform to almost any surface. The goal of this study was to test whether negative pressure application yields reliable fixation of Integra in children undergoing reconstructive surgery.
   Methods: Between 2001 and 2004, VAC was applied in 18 children (n = 18) aged 7 months to 16.5 years. All required reconstructive surgery with implantation of Integra covering 1% to 12% of the total body surface area. After Integra implantation, VAC was installed for 13 to 30 days.
   Results: The VAC fixation of Integra was successful in 17 patients (94.5%). The only failure (5.5%) occurred in a patient in whom negative pressure could not be maintained because of a lesion site susceptible to both dislodgement and infection (perianal region). Consequently, infection occurred, and Integra had to be removed.
   Conclusions: These results demonstrate that VAC is a valid tool for reliable fixation of Integra in children undergoing even demanding reconstructive surgery. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Stiefel, Dorothea; Schiestl, Clemens M.; Meuli, Martin] Univ Childrens Hosp Zurich, Dept Surg, Pediat Burn Ctr Plast & Reconstruct Surg, CH-8032 Zurich, Switzerland.
C3 University Children's Hospital Zurich
RP Stiefel, D (通讯作者)，Univ Childrens Hosp Zurich, Dept Surg, Pediat Burn Ctr Plast & Reconstruct Surg, CH-8032 Zurich, Switzerland.
EM stiefel_d@yahoo.co.uk
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   BURKE JF, 1981, ANN SURG, V194, P413, DOI 10.1097/00000658-198110000-00005
   Dantzer E, 2001, BRIT J PLAST SURG, V54, P659, DOI 10.1054/bjps.2001.3684
   HEIMBACH D, 1988, ANN SURG, V208, P313, DOI 10.1097/00000658-198809000-00008
   Heimbach DM, 2003, J BURN CARE REHABIL, V24, P42, DOI 10.1097/00004630-200301000-00009
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
   Moiemen NS, 2006, PLAST RECONSTR SURG, V117, p160S, DOI 10.1097/01.prs.0000222609.40461.68
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NR 12
TC 47
Z9 52
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAR
PY 2009
VL 44
IS 3
BP 575
EP 580
DI 10.1016/j.jpedsurg.2008.07.006
PG 6
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 426UN
UT WOS:000264733600018
PM 19302862
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Zamfir, AS
   Maxim, M
   Zamfir, CL
   Ciuntu, RE
   Zabara, ML
   Abdulan, IM
   Corlade-Andrei, M
   Timofte, DV
   Balan, GG
AF Ciuntu, Bogdan Mihnea
   Zamfir, Alexandra-Simona
   Maxim, Madalina
   Zamfir, Carmen Lacramioara
   Ciuntu, Roxana Elena
   Zabara, Mihai Lucian
   Abdulan, Irina Mihaela
   Corlade-Andrei, Mihaela
   Timofte, Daniel Vasile
   Balan, Gheorghe G.
TI Management of Gastric Fistulas After Gastric Sleeve Using E-VAC Therapy
SO DIAGNOSTICS
LA English
DT Article
DE gastric fistula; endoluminal vacuum assisted closure; sleeve
   gastrectomy; obesity; multidisciplinary approach
ID PRESSURE WOUND THERAPY; ANASTOMOTIC LEAKAGE; ASSISTED CLOSURE;
   GASTRECTOMY; COMPLICATIONS; STENT
AB Background and Clinical Significance: Sleeve gastrectomy is an effective and widely performed bariatric procedure that provides long-term, sustained weight loss, but it carries risks of early and late complications. Among these, gastric fistula is a rare occurrence associated with an increased mortality rate and must be carefully considered to ensure timely diagnosis and appropriate management. Case Presentation: We will present the complex case of a patient who was referred to the general surgery department due to severe abdominal pain, exertional dyspnea, nausea, fever and fatigue, symptoms that appeared one month after a robotic gastric sleeve. The investigations led to the diagnostic of high gastric fistula secondary to a gastric sleeve procedure. The patient underwent exploratory laparotomy with jejunostomy, peritoneal lavage, drainage, and endoscopic placement of an endoluminal vacuum assisted closure (E-VAC) system. Close clinical, laboratory, imaging, and endoscopic monitoring demonstrated progressive improvement, with complete resolution of the fistula achieved after seven weeks of E-VAC therapy. Conclusions: The particularity of this case lies in the occurrence of a delayed mechanical gastric suture dehiscence, with late diagnosis, managed using E-VAC. Even though rare, gastric fistulas represent a potentially life-threatening complication of sleeve gastrectomy. Early diagnosis and a multidisciplinary approach, which includes infection control, surgical intervention and minimally invasive techniques like E-VAC, are essential for effective management and favorable outcomes.
C1 [Ciuntu, Bogdan Mihnea; Maxim, Madalina; Zabara, Mihai Lucian; Abdulan, Irina Mihaela; Corlade-Andrei, Mihaela; Timofte, Daniel Vasile] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
   [Ciuntu, Bogdan Mihnea; Maxim, Madalina; Zabara, Mihai Lucian; Abdulan, Irina Mihaela; Timofte, Daniel Vasile] Cty Clin Emergency Hosp St Spiridon, Dept Gen Surg, Iasi 700111, Romania.
   [Zamfir, Alexandra-Simona] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Pulmonol, Iasi 700115, Romania.
   [Zamfir, Carmen Lacramioara] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Morpho Funct Sci 1, Iasi 700115, Romania.
   [Ciuntu, Roxana Elena] Grigore T Popa Univ Med & Pharm, Dept Ophtalmol, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Emergency St Spiridon Cty Hosp, Iasi 700111, Romania.
   [Balan, Gheorghe G.] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med 1, Med Semiol & Gastroenterol, 16 Univ St, Iasi 700115, Romania.
   [Balan, Gheorghe G.] St Spiridon Cty Hosp, Gastroenterol Ward 2, Independence Bvd 1, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Zamfir, AS (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Sci 3, Pulmonol, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; simona-zamfir@umfiasi.ro;
   madalina.maxim@umfiasi.ro; carmen.zamfir@umfiasi.ro;
   roxana-elena.ciuntu@umfiasi.ro; mihai-lucian.zabara@umfiasi.ro;
   irina.abdulan@umfiasi.ro; mihaela.corlade2@umfiasi.ro;
   daniel.timofte@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Ciuntu, Bogdan/MTF-9477-2025; Zamfir, Carmen Lacramioara/AAG-2936-2021;
   Timofte, Daniel/AAE-2511-2019; Mihai Lucian, Zabara/JYD-6642-2024;
   Balan, Gheorghe/OZF-7157-2025; Zamfir, Alexandra-Simona/HNR-0426-2023;
   Corlade-Andrei, Mihaela/HGB-3725-2022; Abdulan, Irina/AAA-3089-2020
OI Ciuntu, Bogdan/0000-0001-7911-0699; Zamfir, Carmen
   Lacramioara/0000-0002-8431-6904; Timofte, Daniel/0000-0002-6604-874X;
   Mihai Lucian, Zabara/0000-0001-9260-6322; 
CR Allen D, 2014, INT WOUND J, V11, P198, DOI 10.1111/j.1742-481X.2012.01073.x
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   Ferraz AAB, 2021, OBES SURG, V31, P1196, DOI 10.1007/s11695-020-05115-w
   Gefen A, 2024, INT WOUND J, V21, DOI [10.1111/iwj.70098, 10.1111/iwj.70098]
   Gensthaler L, 2024, OBES SURG, V34, P3306, DOI 10.1007/s11695-024-07367-2
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   Han YK, 2020, INT J SURG, V76, P101, DOI 10.1016/j.ijsu.2020.02.035
   de Moura DTH, 2019, WORLD J GASTRO ENDOS, V11, P329, DOI 10.4253/wjge.v11.i5.329
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Intriago JMV, 2022, OBES SURG, V32, P3435, DOI 10.1007/s11695-022-06228-0
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   Leeds SG, 2016, SURG OBES RELAT DIS, V12, P1278, DOI 10.1016/j.soard.2016.01.017
   Livingstone I, 2021, CLIN ENDOSC, V54, P787
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   McKanna Melissa, 2016, Ostomy Wound Manage, V62, pS1
   Mennigen R, 2015, J GASTROINTEST SURG, V19, P1229, DOI 10.1007/s11605-015-2847-7
   Noh SM, 2018, GASTROENT RES PRACT, V2018, DOI 10.1155/2018/1697968
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   Rycerz AM, 2013, INT WOUND J, V10, P214, DOI 10.1111/j.1742-481X.2012.00968.x
   Schniewind B, 2013, SURG ENDOSC, V27, P3883, DOI 10.1007/s00464-013-2998-0
   Shi XZ, 2010, OBES SURG, V20, P1171, DOI 10.1007/s11695-010-0145-8
   Smallwood NR, 2016, SURG ENDOSC, V30, P2473, DOI 10.1007/s00464-015-4501-6
   Vilar A, 2020, CIR ESPAN, V98, P639, DOI 10.1016/j.ciresp.2019.12.011
   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Weidenhagen R, 2004, SHOCK, V21, P152, DOI 10.1097/00024382-200403001-00608
   Wozniewska P, 2021, GASTROENTEROL REV, V16, P5, DOI 10.5114/pg.2021.104733
NR 35
TC 0
Z9 1
U1 3
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD NOV 6
PY 2025
VL 15
IS 21
AR 2811
DI 10.3390/diagnostics15212811
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9RC7D
UT WOS:001613032900001
PM 41226103
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Weidenhagen, R
   Gruetzner, KU
   Wiecken, T
   Spelsberg, F
   Jauch, KW
AF Weidenhagen, Rolf
   Gruetzner, Klaus Uwe
   Wiecken, Timm
   Spelsberg, Fritz
   Jauch, Karl-Walter
TI Endoscopic vacuum-assisted closure of anastomotic leakage following
   anterior resection of the rectum: a new method
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE endoscopic; closure; anastomotic; leakage; resection; rectum
ID WOUND CONTROL; RISK-FACTORS; COMPLICATIONS; MANAGEMENT; SURGERY
AB Background Conservative treatment of anastomotic leakage after anterior resection of the rectum seems to be possible in patients who have no occurrence of generalized peritonitis. This report describes a new method of endoscopic management of large anastomotic leakage in these patients.
   Method The main feature of this new method is the endoscopically assisted placement of an open-cell sponge connected to a vacuum device into the abscess cavity via an introducer device. The sponge system is changed every 48-72 h.
   Results Twenty-nine patients with an anastomotic leakage after anterior resection were treated with the endoscopic vacuum therapy. The total duration of endovac therapy was 34.4 +/- 19.4 days. The total number of endoscopic sessions per patient was 11.4 +/- 6.3. In 21 of the 29 patients, a protecting stoma was created at the primary operation. Four patients were treated successfully without the need of a secondary stoma. Definitive healing was achieved in 28 of the 29 patients.
   Conclusions Endoscopic vacuum-assisted closure is a new efficacious modality for treating anastomotic leakage following anterior resection due to an effective control of the septic focus. Further studies will show if it is possible to reduce the high mortality rate of patients with anastomotic leakage through the avoidance of surgical reinterventions while at the same time preserving the sphincter function.
C1 [Weidenhagen, Rolf; Wiecken, Timm; Spelsberg, Fritz; Jauch, Karl-Walter] Univ Munich, Dept Surg, Klinikum Grosshadern, D-81377 Munich, Germany.
   [Gruetzner, Klaus Uwe] Univ Witten Herdecke, Clin Visceral Vasc & Transplant Surg, Clin Cologne Merheim, D-51109 Cologne, Germany.
C3 University of Munich; Witten Herdecke University
RP Weidenhagen, R (通讯作者)，Univ Munich, Dept Surg, Klinikum Grosshadern, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
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NR 29
TC 263
Z9 311
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD AUG
PY 2008
VL 22
IS 8
BP 1818
EP 1825
DI 10.1007/s00464-007-9706-x
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 327KK
UT WOS:000257727800012
PM 18095024
DA 2026-07-24
ER

PT J
AU Maheshwari, V
   Danish, 
   Olkha, V
   Dhingra, M
   Sharma, C
   Regmi, A
AF Maheshwari, Vikas
   Danish, V
   Olkha, Vikas
   Dhingra, Mohit
   Sharma, Cury
   Regmi, Anil
TI Calcific Myonecrosis: Case Report of a Rare Clinical Presentation and
   Literature Review
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Calcific myonecrosis; En bloc excision; Antero-lateral compartment;
   Vacuum-assisted closure (VAC); Surgical management; Case report
ID DIAGNOSIS
AB Introduction and ImportanceCalcific myonecrosis is a rare entity characterized by coagulative and liquefactive necrosis with calcifications of the entire muscle mass of the involved compartment secondary to post-traumatic compartment syndrome. There is limited literature on the rare disease with technical difficulties and pitfalls of operative procedures in these patients.Presentation of CaseA 52-year-old male presented with complaints of swelling over his right leg with discharging sinus over the past 2 years following a surgical intervention. He was diagnosed as a case of calcific myonecrosis based on history and clinico-radio-histological correlation and was managed successfully with en bloc excision with vacuum-assisted closure (VAC) of wound.Clinical DiscussionA rare musculoskeletal condition is characterized by muscle necrosis and extensive calcification within a limb compartment, typically following post-traumatic compartment syndrome involving muscle and neurovascular structures. Diagnosis relies heavily on radiological findings, such as calcifications and adjacent bone erosions, while histopathology is crucial to exclude malignancy. A high index of clinical suspicion is essential for timely identification.ConclusionCalcific myonecrosis requires a multi-factorial approach to reach to a diagnosis, with ruling out the differentials and proper preoperative plan are the key to success. If un-infected, it is a "Touch me not disease"; however, through debridement or en-mass excision of compartment with VAC therapy should be considered for infected cases.
C1 [Maheshwari, Vikas; Olkha, Vikas; Dhingra, Mohit; Sharma, Cury; Regmi, Anil] All India Inst Med Sci, Dept Orthopaed, Rishikesh, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Dhingra, M (通讯作者)，All India Inst Med Sci, Dept Orthopaed, Rishikesh, India.
EM 111vikasmaheshwari@gmail.com; danishvayoli@gmail.com; viksvx@gmail.com;
   modisbanu77@gmail.com; curiesharma10@gmail.com; regmiaanil@gmail.com
RI Regmi, Anil/NBX-3164-2025
OI Regmi, Anil/0000-0002-9182-4851; , vikas/0009-0004-7621-7369;
   Maheshwari, Vikas/0000-0002-8631-6334
CR Angelini A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090542
   elsevier, CALCIFIC MYONECROSIS
   Gangrade K, 2019, Case Reports in Orthopedic Research, V2, P47, DOI [10.1159/000502031, 10.1159/000502031, DOI 10.1159/000502031]
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NR 11
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD JUL
PY 2025
VL 59
IS 7
BP 1000
EP 1006
DI 10.1007/s43465-025-01428-z
EA JUN 2025
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 4TZ8C
UT WOS:001501874400001
PM 40657225
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Agel, J
   Rockwood, T
   Barber, R
   Marsh, JL
AF Agel, Julie
   Rockwood, Todd
   Barber, Richard
   Marsh, J. Lawrence
TI Potential Predictive Ability of the Orthopaedic Trauma Association Open
   Fracture Classification
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE prediction of treatment; prediction of outcome; open fracture
   classification
AB Objective:
   Is the OTA open fracture classification (OTA-OFC) potentially predictive of early amputation and specific clinical treatments?
   Design:
   Retrospective chart review of prospectively collected data.
   Setting:
   Level I trauma center, Seattle, WA.
   Patients/Participants:
   Three hundred fifty-six patients with open fractures of the femur, tibia, malleoli, humerus, radius/ulna, pelvis, acetabulum, foot, or clavicle.
   Intervention:
   No intervention.
   Main Outcome Measurements:
   Vacuum-assisted closure placement, 3+ irrigation and debridements, antibiotic bead placement, and early amputation.
   Results:
   The OTA-OFC is related to the type of treatment used to treat an open fracture. The model demonstrated that the strongest potential predictor of vacuum-assisted closure use is the severity of the skin injury; multiple debridements (>= 2) is best predicted by the severity of the skin injury and muscle injury; bone loss was the strongest potential predictor of antibiotic bead placement; and the strongest predictors of early amputation are skin injury, contamination, and arterial injury.
   Conclusions:
   Exploratory analysis of these data demonstrates that variations in muscle damage, skin injury, bone loss, arterial injury, and contamination sustained in an open fracture are related to different treatments in the total study population and for anatomical regions. The information provided by this study demonstrates that the OTA-OFC may have predictive abilities relative to how an open fracture is treated.
   Level of Evidence:
   Prognostic level II. See Instructions for Authors for a complete description of levels of evidence.
C1 [Agel, Julie] Univ Washington, Harborview Med Ctr, Dept Orthopaed & Sports Med, Seattle, WA 98104 USA.
   [Rockwood, Todd] Univ Minnesota, Div Hlth Policy & Management, Minneapolis, MN USA.
   [Barber, Richard] Christus Spohn Mem Hosp, Corpus Christi, TX USA.
   [Marsh, J. Lawrence] Univ Iowa Hosp & Clin, Dept Orthopaed Surg, Iowa City, IA 52242 USA.
C3 Harborview Medical Center; University of Washington; University of
   Washington Seattle; University of Minnesota System; University of
   Minnesota Twin Cities; University of Iowa
RP Agel, J (通讯作者)，Univ Washington, Harborview Med Ctr, Dept Orthopaed & Sports Med, Box 359798,325 Ninth Ave, Seattle, WA 98104 USA.
EM bagel@u.washington.edu
OI Rockwood, Todd/0000-0001-6234-435X; Marsh, J
   Lawrence/0000-0002-3494-6289
CR Agel J, 2013, J ORTHOP TRAUMA, V27, P379, DOI 10.1097/BOT.0b013e3182820d31
   Evans AR, 2010, J ORTHOP TRAUMA, V24, P457, DOI 10.1097/BOT.0b013e3181c7cb6b
   GUSTILO RB, 1976, J BONE JOINT SURG AM, V58, P453, DOI 10.2106/00004623-197658040-00004
   Marsh JL, 2007, J ORTHOP TRAUMA, V21, pS1, DOI 10.1097/00005131-200711101-00001
NR 4
TC 25
Z9 31
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAY
PY 2014
VL 28
IS 5
BP 300
EP 306
DI 10.1097/BOT.0b013e3182a70f39
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA AF7SI
UT WOS:000334914600013
PM 24045435
DA 2026-07-24
ER

PT J
AU Pliakos, I
   Michalopoulos, N
   Papavramidis, TS
   Arampatzi, S
   Diza-Mataftsi, E
   Papavramidis, S
AF Pliakos, Ioannis
   Michalopoulos, Nikolaos
   Papavramidis, Theodossis S.
   Arampatzi, Stergiani
   Diza-Mataftsi, Eudoxia
   Papavramidis, Spiros
TI The Effect of Vacuum-Assisted Closure in Bacterial Clearance of the
   Infected Abdomen
SO SURGICAL INFECTIONS
LA English
DT Article
ID INTENSIVE-CARE-UNIT; GRAM-NEGATIVE BACILLI; SEVERE PERITONITIS;
   SURGICAL-PATIENTS; ABDOMINAL SEPSIS; LAPAROSTOMY; MANAGEMENT;
   RESISTANCE; STATES; SUSCEPTIBILITY
AB Background: Laparostomy with vacuum-assisted closure (VAC) plays an important role in improving survival in the presence of abdominal infection. We conducted a study of the qualitative changes in the bacterial flora of the peritoneal cavity in patients with severe abdominal infection treated with laparostomy and a VAC device. Methods: Thirty-nine patients with severe abdominal infection treated with abdominal opening and VAC were registered in a clinical study. When an incidence of 53.8% of hospital-acquired peritoneal infection (HAPI) was found in the study patient population, it was decided to divide the patients in two groups according to whether or not they developed a HAPI. The patients' outcomes were then analyzed. Results: The durations of abdominal opening (p=0.04), length of stay in the intensive care unit (ICU) (p=0.01), and of hospitalization (p=0.04) were significantly greater in patients with HAPI than in those without it, whereas mortality did not differ on the basis of these three variables. Conclusions: Superinfection is common in laparostomy done with a VAC device for managing severe abdominal infection. The data in the present study show that VAC does not alter the quality of the bacterial burden in primary abdominal contamination, nor does it seem to prevent a high incidence of HAPI. However, VAC is as effective in reducing mortality among patients with HAPI as among those without it.
C1 [Pliakos, Ioannis; Michalopoulos, Nikolaos; Papavramidis, Theodossis S.; Papavramidis, Spiros] Aristotle Univ Thessaloniki, Dept Surg 3, AHEPA Univ Hosp, GR-54006 Thessaloniki, Greece.
   [Arampatzi, Stergiani; Diza-Mataftsi, Eudoxia] Aristotle Univ Thessaloniki, Dept Microbiol 2, AHEPA Univ Hosp, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   Aristotle University of Thessaloniki; Ahepa University Hospital
RP Pliakos, I (通讯作者)，Lysimachou 3, Thessaloniki 54645, Greece.
EM plliakos@hotmail.com
RI Papavramidis, Theodossis/E-8260-2011; Michalopoulos, Nickos/I-6159-2013;
   Papavramidis, Theodossis/E-8260-2011
OI Papavramidis, Theodossis/0000-0002-7097-9889; Michalopoulos,
   Nickos/0000-0002-7740-4922; Papavramidis, Theodossis/0000-0002-7097-9889
CR Amin AI, 2009, WORLD J GASTROENTERO, V15, P3394, DOI 10.3748/wjg.15.3394
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   Sligl W, 2006, INT J INFECT DIS, V10, P320, DOI 10.1016/j.ijid.2005.07.003
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   Stevens P, 2009, INT WOUND J, V6, P259, DOI 10.1111/j.1742-481X.2009.00614.x
   Streit JM, 2004, INT J ANTIMICROB AG, V24, P111, DOI 10.1016/j.ijantimicag.2003.12.019
   Subramonia S, 2009, WORLD J SURG, V33, P931, DOI 10.1007/s00268-009-9947-z
   Vargo D, 2009, AM SURGEON, V75, pS1
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   Zhanel GG, 2008, ANTIMICROB AGENTS CH, V52, P1430, DOI 10.1128/AAC.01538-07
NR 36
TC 19
Z9 22
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB 1
PY 2014
VL 15
IS 1
BP 18
EP 23
DI 10.1089/sur.2012.156
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AA9BE
UT WOS:000331387900004
PM 24286126
DA 2026-07-24
ER

PT J
AU von Rüden, C
   Benninger, E
   Mayer, D
   Trentz, O
   Labler, L
AF von Rueden, Christian
   Benninger, Emanuel
   Mayer, Dieter
   Trentz, Otmar
   Labler, Ludwig
TI Bogota-VAC - A Newly Modified Temporary Abdominal Closure Technique
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Abdominal compartment syndrome (ACS); Intra-abdominal pressure (IAP);
   Temporary abdominal closure (TAC); Vacuum-assisted closure (VAC); Volume
   reserve capacity (VRC)
ID COMPARTMENT SYNDROME; TRAUMA; PACK
AB Background: We present Bogota-VAC, a newly modified temporary abdominal closure (TAC) technique for open abdomen condition after abdominal compartment syndrome (ACS).
   Methods: A thin isolation bag (Bogota bag) and a vacuum assisted closure (VAC) system were combined. A matching bag was tension-free fixed on the abdominal fascia by fascia suture. A ring shaped black polyurethane foam of the VAC system was placed into the gap between Bogota bag, abdominal fascia and the wound edge. A constant negative topic pressure of 50-75 mmHg was used in the VAC system.
   Results: Intra-abdominal pressure (IAP: 22 +/- 2 mmHg) of four patients with ACS after severe traumatic brain injury and one patient with isolated ACS after blunt abdominal trauma decreased significantly (p = 0.01) after decompressive laparotomy and treatment with Bogota-VAC (IAP: 10 +/- 2 mmHg) and remained low, measured via urinary bladder pressure. Intracranial pressure (ICP) in the four traumatic brain injury patients decreased from 42 +/- 13 mmHg to 15 +/- 3 mmHg after abdominal decompression. Cerebral perfusion pressure (57 14 mmHg) increased to 74 +/- 2 mmHg.
   Conclusion: The advantage of the presented Bogota-VAC is leak tightness, wound conditioning (soft tissue/fascia), skin protection and facilitation of nursing in combination with highest volume reserve capacity (VRC), thus preventing recurrent increased intra-abdominal and intracranial pressure in the initial phase after decompression of ACS compared to other TAC techniques.
C1 [von Rueden, Christian; Benninger, Emanuel; Trentz, Otmar; Labler, Ludwig] Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland.
   [Mayer, Dieter] Univ Zurich Hosp, Dept Surg, Div Cardiovasc Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP von Rüden, C (通讯作者)，Univ Zurich Hosp, Dept Surg, Div Trauma Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM christian.vonrueden@usz.ch
RI Mayer, Dieter/E-7617-2011
OI Mayer, Dieter/0000-0001-5933-7749
CR [Anonymous], EUR J TRAUMA
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   *WORLD SOC ABD COM, CONS DEF REC
NR 13
TC 14
Z9 14
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD DEC
PY 2008
VL 34
IS 6
BP 582
EP 586
DI 10.1007/s00068-008-8007-y
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 384EB
UT WOS:000261726000010
PM 26816283
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Poller, WC
   Schwerg, M
   Melzer, C
AF Poller, Wolfram C.
   Schwerg, Marius
   Melzer, Christoph
TI Therapy of Cardiac Device Pocket Infections with Vacuum-Assisted Wound
   Closure - Long-Term Follow-Up
SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
LA English
DT Article
DE cardiac device infection; local device infection; vacuum-assisted
   closure (V; A; C; ); pacemaker; implantable cardioverter defibrillator
   (AICD)
ID IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; LEAD EXTRACTION; PACEMAKER
   LEADS; POSTSTERNOTOMY MEDIASTINITIS; PERMANENT PACEMAKER; MANAGEMENT;
   REMOVAL; COMPLICATIONS; ENDOCARDITIS; EXPERIENCE
AB Background: Cardiac device infections are serious complications that require aggressive treatment strategies, including interventional or surgical lead extraction. Methods: Here we describe the long-time follow-up of vacuum-assisted closure (V.A.C.) treatment in five patients with local cardiac device infection (LDI). In these patients the device was removed, the electrodes were shortened, and a V.A.C. treatment was applied. The primary endpoint was defined as time to re-LDI. Results: Three patients had LDI of a pacemaker pocket, whereas two presented with an infection of their ICD pocket. The V.A.C. treatment was applied for 34.4 +/- 17.9 days. The mean hospitalization time was 38.6 +/- 19.2 days. The follow-up period was assessed for 34.6 +/- 19.2 months. Only one patient developed re-LDI, 69 days after removal of the device. The other four patients did not show any signs of reinfection during the follow-up period. None of the five patients sustained serious adverse events. Conclusions: V.A.C. treatment may be an option for selected patients with LDI who refuse a laser-guided lead extraction or surgical removal of the electrodes as the primary therapy. (PACE 2012; 35:12171221)
C1 [Poller, Wolfram C.; Schwerg, Marius; Melzer, Christoph] Charite, Dept Cardiol & Angiol, Berlin, Germany.
C3 Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Poller, WC (通讯作者)，Med Klin Schwerpunkt Kardiol & Angiol, Charite Campus Mitte, Schumannstr 20-21, D-10117 Berlin, Germany.
EM wolfram.poller@charite.de
RI Poller, Wolfram/AAB-2185-2021
OI Poller, Wolfram/0000-0002-4632-5551
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Chua JD, 2000, ANN INTERN MED, V133, P604, DOI 10.7326/0003-4819-133-8-200010170-00011
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   Habib G, 2009, EUR HEART J, V30, P2369, DOI 10.1093/eurheartj/ehp285
   Hamid S, 2009, EUROPACE, V11, P213, DOI 10.1093/europace/eun374
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   HURST LN, 1986, PACE, V9, P785, DOI 10.1111/j.1540-8159.1986.tb06628.x
   Klug D, 1997, CIRCULATION, V95, P2098, DOI 10.1161/01.CIR.95.8.2098
   Lee JH, 1996, PACE, V19, P437, DOI 10.1111/j.1540-8159.1996.tb06514.x
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   Satsu T, 2010, PACE, V33, P426, DOI 10.1111/j.1540-8159.2009.02661.x
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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   Victor F, 1999, HEART, V81, P82, DOI 10.1136/hrt.81.1.82
NR 32
TC 12
Z9 16
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0147-8389
EI 1540-8159
J9 PACE
JI PACE-Pacing Clin. Electrophysiol.
PD OCT
PY 2012
VL 35
IS 10
BP 1217
EP 1221
DI 10.1111/j.1540-8159.2012.03479.x
PG 5
WC Cardiac & Cardiovascular Systems; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Engineering
GA 015MG
UT WOS:000309449600013
PM 22845624
DA 2026-07-24
ER

PT J
AU de Laat, EHEW
   van den Boogaard, MHWA
   Spauwen, PHM
   van Kuppevelt, DHJM
   van Goor, H
   Schoonhoven, L
AF de laat, Erik H. E. W.
   van den Boogaard, Mark H. W. A.
   Spauwen, Paul H. M.
   van Kuppevelt, Dirk H. J. M.
   van Goor, Harry
   Schoonhoven, Lisette
TI Faster Wound Healing With Topical Negative Pressure Therapy in
   Difficult-to-Heal Wounds A Prospective Randomized Controlled
   Trial
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE topical negative pressure; vacuum-assisted closure; sodium hypochlorite;
   difficult-to-heal wounds; pressure ulcer
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; MANAGEMENT; SYSTEM; SORES
AB Objective: A randomized clinical trial was conducted to determine the effectiveness and safety of topical negative pressure therapy in patients with difficult-to-heal wounds.
   Methods: A total of 24 patients were randomly assigned to either treatment with topical negative pressure therapy or treatment with conventional dressing therapy with sodium hypochlorite. The study end point was 50% reduction in wound volume. The maximum follow-up time was 6 weeks.
   Results: The median treatment time to 50% reduction of wound volume in the topical negative pressure group was 2.0 weeks (interquartile range = 1) versus 3.5 weeks (interquartile range = 1.5) in the sodium hypochlorite group (P < 0.001). The unadjusted hazard rate ratio for the time until 50% wound volume reduction was 0.123 (P < 0.001). After adjustment for relevant baseline characteristics in a Cox proportional hazards model treatment group, membership was found as the only and statistically significant indicator for the time to 50% wound volume reduction (hazard rate ratio of 0.117 [P < 0.001]). Subgroup analysis of spinal cord injured patients with severe pressure ulcers showed similar statistically significant results as in the total wound group.
   Conclusion: Topical negative pressure resulted in almost 2 times faster wound healing than treatment with sodium hypochlorite, and is safe to use in patients with difficult-to-heal wounds.
C1 [de laat, Erik H. E. W.; Spauwen, Paul H. M.; van Goor, Harry] Radboud Univ Nijmegen, Med Ctr, Dept Plast Surg, NL-6500 HB Nijmegen, Netherlands.
   [van den Boogaard, Mark H. W. A.] Radboud Univ Nijmegen, Med Ctr, Res Dept Intens & Crit Care, NL-6500 HB Nijmegen, Netherlands.
   [van Kuppevelt, Dirk H. J. M.] Rehabil Ctr, St Maartensklin, Nijmegen, Netherlands.
   [Schoonhoven, Lisette] Radboud Univ Nijmegen, Med Ctr, IQ Sci Inst Qual Healthcare, NL-6500 HB Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Sint Maartens
   Clinic; Radboud University Nijmegen
RP de Laat, EHEW (通讯作者)，Radboud Univ Nijmegen, Med Ctr, Dept Plast Surg 926, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM e.delaat@plchir.umcn.nl
RI van den Boogaard, RN,, Mark/N-5857-2014; Schoonhoven,
   Lisette/O-3330-2013; /P-8241-2015; van Goor, H./H-8035-2014
OI van den Boogaard, RN,, Mark/0000-0003-4233-2903; 
FU department of Nijmegen University Medical Centre
FX the surgical department of Nijmegen University Medical Centre granted
   this study. There is no conflict of interest for this study.
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NR 31
TC 42
Z9 43
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2011
VL 67
IS 6
BP 626
EP 631
DI 10.1097/SAP.0b013e31820b3ac1
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 862JB
UT WOS:000298085900025
PM 21629111
DA 2026-07-24
ER

PT J
AU Gesslein, M
   Horch, RE
AF Gesslein, M
   Horch, RE
TI Interdisciplinary management of complex chronic ulcers using vacuum
   assisted closure therapy and "buried chip skin grafts"
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nuernberg, GERMANY
DE VAC (R)-therapy; diabetic foot syndrome; buried chip skin grafts
AB History and admission findings: We report the case of a 68-year-old female patient who was admitted to the hospital with deranged blood sugar levels in a septic condition. Due to complex chronic ulcerations of both feet she was intended for major amputation of both limbs. Clinical findings on admission were a diabetic foot syndrome with stage DIV ulcerations according to the Wagner and Armstrong classification, partially visible tendons and phlegmon of the lower leg. Investigations and clinical course: Vascular diagnostic revealed arterial occlusive disease in the lower legs without chance of reconstruction. Enterococcus faecalis and Staphylococcus aureus were extracted in swabs from ulcers. After correction of metabolic status and antibiotic treatment radical debridement of all ulcers was carried out and vacuum assisted closure therapy (V.A.C.(R)) was initiated. All wounds showed good granulation tissue after four cycles of V.A.C.(R)-therapy. Interdisciplinary treatment with a plastic surgeon was initiated to accelerate epithelial closure. Using the "Buried Skin Chip" technique in combination with V.A.C.(R)-therapy epithelialisation was completed within four weeks. The patient recovered well and was fully independent on discharge. Discussion and Conclusion: A goal-oriented interdisciplinary setting can achieve preservation of extremities even in septic patients. The combination of buried skin chip grafts and V.A.C.(R)-therapy may be a feasible and promising procedure to achieve accelerated wound closure in those patients.
C1 Klinikum Nurnberg Sud, Klin Unfall & Orthopad Chirurg, D-90471 Nurnberg, Germany.
   Univ Erlangen Nurnberg, Chirurg Klin & Poliklin, Abt Plast & Handchirurg, D-8520 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Gesslein, M (通讯作者)，Klinikum Nurnberg Sud, Klin Unfall & Orthopad Chirurg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM mgesslein@aol.com
RI Horch, Raymund E/H-8128-2019; Gesslein, Markus/O-4858-2019
OI Horch, Raymund E/0000-0002-6561-2353; Gesslein,
   Markus/0000-0003-3863-1580
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   GOLDBERG JA, 1991, CLIN PLAST SURG, V18, P459
   Kopp J, 2004, ZBL CHIR, V129, pS129, DOI 10.1055/s-2004-822649
   Kopp Jurgen, 2004, Int J Low Extrem Wounds, V3, P168, DOI 10.1177/1534734604268092
   Sawada Y, 1998, Acta Chir Plast, V40, P68
   SAWADA Y, 1989, BURNS, V15, P36, DOI 10.1016/0305-4179(89)90067-3
NR 6
TC 12
Z9 13
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S170
EP S173
DI 10.1055/s-2006-921460
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 034DB
UT WOS:000236904100041
PM 16575674
DA 2026-07-24
ER

PT J
AU Sukur, E
   Akar, A
   Uyar, AÇ
   Cicekli, O
   Kochai, A
   Turker, M
   Topcu, HN
AF Sukur, Erhan
   Akar, Abdulhalim
   Uyar, Ahmet Cagri
   Cicekli, Ozgur
   Kochai, Alauddin
   Turker, Mehmet
   Topcu, Huseyin Nevzat
TI Vacuum-assisted closure versus moist dressings in the treatment of
   diabetic wound ulcers after partial foot amputation: A retrospective
   analysis in 65 patients
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Article
DE diabetic food ulcer; partial foot amputation; reamputation; VAC
ID THERAPY; SURGERY
AB Purpose: Changes in weight-bearing patterns after partial foot amputations may lead to new localized high-pressure points and keratosis due to ulcerations in patients with neuropathies and hypovascular limbs. As a result, diabetic foot ulcers (DFUs) after partial foot amputations are very complex. The aim of this study was to compare the effectiveness of vacuum-assisted closure (VAC) therapy with conventional moist wound dressings in the treatment of diabetic wound ulcers after partial foot amputations. Methods: Sixty-five diabetic patients with a DFU, who had previously undergone partial foot amputation surgery, were assigned to treatment with VAC (group A: 31 patients) or conventional wound moist dressing (group B: 34 patients). The final results were considered as failed treatment if reamputation was required. Conversely, reaching 90% of wound granulation was considered to be a successful endpoint. Results: The average time to reach 90% granulation tissue was significantly lower in group A (7.8 +/- 1.2 weeks vs. 11.1 +/- 1.2 weeks; p < 0.001). However, there was no significant difference regarding the reamputation requirements; 38.7% (12 patients) in group A and 41.2% (14 patients) in group B, (p = 0.839). Conclusion: The results of this study allowed us to conclude that VAC therapy system appears to be an effective treatment for patients with complex DFUs who had previously undergone partial foot amputation.
C1 [Sukur, Erhan; Akar, Abdulhalim; Uyar, Ahmet Cagri; Cicekli, Ozgur; Kochai, Alauddin; Turker, Mehmet; Topcu, Huseyin Nevzat] Sakarya Univ Res & Training Hosp, Dept Orthopaed & Traumatol, Sakarya, Turkey.
C3 Sakarya University
RP Sukur, E (通讯作者)，Sakarya Univ Res & Training Hosp, Dept Orthopaed & Traumatol, TR-54050 Adapazari, Sakarya, Turkey.
EM erhan_sukur@hotmail.com
RI çiçekli, özgür/C-9200-2019; Kochai, alauddin/LSL-9483-2024; Akar,
   Abdulhalim/MXL-2024-2025
OI çiçekli, özgür/0000-0001-8063-6866; Akar, Abdulhalim/0000-0002-3153-4799
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
   Armstrong DG, 2003, DIABETIC MED, V20, P329, DOI 10.1046/j.1464-5491.2003.00933.x
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Dinc T, 2016, INT J LOW EXTR WOUND, V15, P227, DOI 10.1177/1534734616655924
   Jin YS, 2017, INT J LOW EXTR WOUND, V16, P14, DOI 10.1177/1534734617699318
   Kim PJ, 2015, Wounds, V27, pS2
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   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
   Morbi AHM, 2016, INT J LOW EXTR WOUND, V15, P96, DOI 10.1177/1534734615595564
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
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   Reiber GE, 2002, DIABETIC FOOT: MEDICAL AND SURGICAL MANAGEMENT, P35
   Robert N, 2017, ORTHOP TRAUMATOL-SUR, V103, pS99, DOI 10.1016/j.otsr.2016.04.018
   Sage RA, 2010, FOOT ANKLE CLIN, V15, P495, DOI 10.1016/j.fcl.2010.04.006
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NR 20
TC 6
Z9 8
U1 1
U2 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1022-5536
EI 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PD SEP 20
PY 2018
VL 26
IS 3
AR 2309499018799769
DI 10.1177/2309499018799769
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GU4UR
UT WOS:000445280800001
PM 30235975
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kiyokawa, K
   Takahashi, N
   Rikimaru, H
   Yamauchi, T
   Inoue, Y
AF Kiyokawa, Kensuke
   Takahashi, Nagahiro
   Rikimaru, Hideaki
   Yamauchi, Toshihiko
   Inoue, Yojiro
TI New continuous negative-pressure and irrigation treatment for infected
   wounds and intractable ulcers
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Background: Continuous irrigation and the vacuum-assisted closure system are effective methods for the treatment of infected wounds and intractable ulcers. The objective of this study was to simultaneously use both of the above methods as a new approach for obtaining more satisfactory, accelerated wound healing.
   Methods: After debridement of the wound, indwelling irrigation and aspiration tubes are placed in the wounds that have been sutured closed. With open wounds, a sponge with the same shape as the wound is placed directly onto the wound surface, and after the two tubes are inserted in the sponge, the wound is covered with film dressing to make the wound completely airtight. A bottle of physiologic saline solution is then attached to the irrigation tube, and a continuous aspirator (Mera Sacume) is attached to the aspiration tube. The bottle of physiologic saline solution is placed at the same height as the wound, and with a pressure gradient between the two of 0, continuous aspiration is applied.
   Results: All nine cases treated as closed air cavity wounds with this method healed after 2 to 3 weeks. In eight cases of open wound, recurrence of infection was observed in only one case.
   Conclusions: The two treatments of continuous irrigation and negative pressure were observed to have an additive and synergistic effect for earlier wound healing. Furthermore, the present method can dramatically reduce the number of dressing changes required, patient pain, psychological stress, and treatment cost.
C1 Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Kiyokawa, K (通讯作者)，Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
RI Kiyokawa, Kensuke/Q-5559-2017
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NR 14
TC 39
Z9 57
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2007
VL 120
IS 5
BP 1257
EP 1265
DI 10.1097/01.prs.0000279332.27374.69
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217VZ
UT WOS:000249976700019
PM 17898598
DA 2026-07-24
ER

PT J
AU Malsiner, CCM
   Schmitz, M
   Horch, RE
   Keller, AK
   Leffler, M
AF Malsiner, Carmen C. M.
   Schmitz, Marweh
   Horch, Raymund E.
   Keller, Andrea K.
   Leffler, Mareike
TI Vessel transformation in chronic wounds under topical negative pressure
   therapy: an immunohistochemical analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Angiogenesis; Hypoxia; Topical negative pressure; Vacuum-assisted
   closure; Vessel proliferation
ID VACUUM-ASSISTED CLOSURE; ARTERIOVENOUS LOOP; TISSUE; HYPOXIA;
   ANGIOGENESIS; GROWTH; PROLIFERATION; EXPRESSION; VAC(R)
AB The underlying physiological mechanism of topical negative pressure (TNP) therapy is not yet completely understood. This prospective clinical study aims to clarify a potential influence of TNP therapy on vessel proliferation and hypoxia in chronic wounds. TNP was applied on chronic wounds of 16 patients (-125 mmHg) to prepare them for a plastic-surgical reconstruction using free or pedicled flaps. Tissue biopsies were taken from the wound edge and wound bed at different time points. All samples were stained with haematoxylin and eosin, hypoxia-induced factor-1 alpha and endothelial cell markers (CD31 and CD34) for the immunohistological analysis of inflammation, hypoxia and vessel proliferation. Between day 5 and day 8 of treatment, a considerable increase in blood vessel density could be observed, reaching a maximum of approximately 200% in contrast to the vessel density prior to treatment. In addition, the number of hypoxic and inflammatory cells was found to be increased at particular time points. This study demonstrates a stimulating effect on vessel proliferation under TNP treatment. TNP appears to support (neo-) angiogenesis and transformation of chronic non-healing wounds in a physiological wound healing process when combined with surgical debridement. This effect underlines the positive influence of TNP in the treatment of chronic wounds as shown by various clinical reports.
C1 [Malsiner, Carmen C. M.; Schmitz, Marweh; Horch, Raymund E.; Leffler, Mareike] Univ Erlangen Nurnberg, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   [Keller, Andrea K.] Univ Erlangen Nurnberg, Dept Med Informat Biometry & Epidemiol, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 51
TC 16
Z9 18
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 501
EP 509
DI 10.1111/iwj.12143
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700002
PM 24028468
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Campbell, BG
   O'Marra, SK
AF Campbell, Bonnie G.
   O'Marra, Shana K.
TI Diagnosis and surgical management of septic peritonitis in small
   animals: A review
SO VETERINARY SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; FREE PLASMA DNA; IONIZED CALCIUM-CONCENTRATION;
   SMALL-INTESTINAL BIOPSY; OPEN ABDOMINAL DRAINAGE; RETROSPECTIVE
   EVALUATION; ANASTOMOTIC LEAKAGE; RISK-FACTORS; GENERALIZED PERITONITIS;
   ENTERECTOMY SITES
AB Background Septic peritonitis (SP) is a complex disease with significant morbidity and mortality. Diagnosis can be challenging, and lack of a timely diagnosis may impact survival.Aim The aim of this review was to synthesize current knowledge on the diagnosis and surgical management of SP in dogs and cats.Conclusions Recent studies suggest refinements of previously reported clinicopathologic criteria improve diagnostic and prognostic accuracy. When evaluating blood-effusion glucose differences, clinicians should be aware of the confounding effects of point of care glucometers. Cytology specimens should be prepared immediately to avoid sample degradation. Advances in imaging have improved the relevance and diagnostic value of ultrasound and computed tomography. Surgical source control that targets the underlying cause is crucial. Accurate assessment of tissue viability may be aided by technologies under development. Anastomotic dehiscence may be reduced by using stapling devices and reinforcement with endogenous or exogenous materials. Evidence for the effectiveness of postoperative drainage via open abdomen +/- vacuum-assisted closure, or closed suction drains, is unclear. Heterogeneity of patient severity and incomplete data limit direct comparisons between studies and highlight opportunities for future investigation.Implications Developments in diagnostic and surgical techniques may improve prognostication and outcomes in septic patients. There are many opportunities for further research into diagnosis and surgical treatment of patients with septic peritonitis.
C1 [Campbell, Bonnie G.; O'Marra, Shana K.] Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA.
C3 Washington State University
RP Campbell, BG (通讯作者)，Washington State Univ, Coll Vet Med, Dept Vet Clin Sci, Pullman, WA 99164 USA.
EM bjgc@wsu.edu
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NR 237
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JAN
PY 2026
VL 55
IS 1
BP 13
EP 31
DI 10.1111/vsu.70024
EA OCT 2025
PG 19
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CM4PJ
UT WOS:001595874700001
PM 41109949
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lectercq, A
   Labeille, B
   Perrot, JL
   Vercherin, P
   Cambazard, F
AF Lectercq, A.
   Labeille, B.
   Perrot, J. -L.
   Vercherin, P.
   Cambazard, F.
TI Skin graft secured by VAC (vacuum-assisted closure) therapy in chronic
   leg ulcers: A controlled randomized study
SO ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
LA English
DT Article
DE VAC therapy; Chronic leg ulcer; Skin graft; Vacuum-associated closure
ID NEGATIVE-PRESSURE THERAPY; CONTROLLED-TRIAL
AB Introduction. - Leg ulcers are a common condition. There have been very few studies of combined therapy involving VAC (vacuum-assisted closure) and skin graft.
   Methods. - We performed a randomized controlled trial of VAC therapy vs. hydrocolloid dressings over 5 days following autologous grafting on chronic leg ulcers. The primary objective was to assess the difference in success (defined as a reduction in wound area of at least 50% at 1 month) between the two dressing methods. Forty-six patients with ulcers present for over one month were included. Following a 7-day hospitalization period, follow-up was performed for 3 months on an outpatient basis.
   Results. - Our study does not demonstrate a statistically significant difference, with a 45.8% success rate in the VAC group vs. 40.9% in the conventional dressing group (P = 0.73). In the venous ulcer group, the success rate was 57.9% for VAC vs. 40% for conventional dressings (P = 0.3). The difference in favor of VAC in this group was not statistically significant, most likely due to an insufficient number of patients studied.
   Conclusion. - Our study does not demonstrate superiority of VAC associated with skin graft over conventional dressings. We observed more complications with VAC (40%) than with conventional dressings (23%) (P = 0.06). (C) 2015 Elsevier Masson SAS. All rights reserved.
C1 [Lectercq, A.; Labeille, B.; Perrot, J. -L.; Cambazard, F.] CHU St Etienne, Hop Nord, Dept Dermatol, F-42055 St Etienne 2, France.
   [Vercherin, P.] CHU St Etienne, Hop Nord, Dept Publ Hlth & Med Informat, F-42055 St Etienne 2, France.
C3 CHU de St Etienne; CHU de St Etienne
RP Labeille, B (通讯作者)，CHU St Etienne, Hop Nord, Dept Dermatol, F-42055 St Etienne 2, France.
EM bruno.labeille@chu-st-etienne.fr
CR Barwell JR, 2004, LANCET, V363, P1854, DOI 10.1016/S0140-6736(04)16353-8
   Falanga V, 1998, ARCH DERMATOL, V134, P293, DOI 10.1001/archderm.134.3.293
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NR 12
TC 17
Z9 22
U1 0
U2 11
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0151-9638
EI 2214-5451
J9 ANN DERMATOL VENER
JI Ann. Dermatol. Venereol.
PD JAN
PY 2016
VL 143
IS 1
BP 3
EP 8
DI 10.1016/j.annder.2015.06.022
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DD8OQ
UT WOS:000370186900002
PM 26718899
DA 2026-07-24
ER

PT J
AU Whitehead, SJ
   Forest-Bendien, VL
   Richard, JL
   Halimi, S
   Van, GH
   Trueman, P
AF Whitehead, Sarah J.
   Forest-Bendien, Veronique L.
   Richard, Jean-Louis
   Halimi, Serge
   Van, Georges Ha
   Trueman, Paul
TI Economic evaluation of Vacuum Assisted Closure® Therapy for the
   treatment of diabetic foot ulcers in France
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cost-effectiveness; Diabetic foot ulcers; Negative pressure therapy; VAC
   (R) Therapy
ID PRESSURE WOUND THERAPY; COST-EFFECTIVENESS; AMPUTATIONS; MULTICENTER;
   PREVALENCE; CARE
AB The objective of the study was to assess the cost-effectiveness of Vacuum Assisted Closure (R) (V.A.C.(R)) Therapy compared with advanced wound care (AWC) for the treatment of diabetic foot ulcers (DFUs) in France. A cost-effectiveness model intended to reflect the management of DFUs was updated for the French setting. The Markov model follows the progression of 1000 hypothetical patients over a 1-year period. The model was populated with French-specific data, obtained from published sources and clinical experts. The analysis evaluated costs and health outcomes, in terms of quality-adjusted life-years (QALYs), wounds healed and amputations, from the perspective of the payer. The patients treated with V.A.C.(R) Therapy experienced more QALYs (0.787 versus 0.784) and improved healing rates (50.2% versus 48.5%) at a lower total cost of care ((sic)24 881 versus (sic)28 855 per patient per year) when compared with AWC. Sensitivity analyses conducted around key model parameters indicated that the results were affected by hospital resource use and costs. DFU treatment using V.A.C.(R) Therapy in France was associated with lower costs, additional QALYs, more healed ulcers and fewer amputations than treatment with AWC. V.A.C.(R) Therapy was therefore found to be the dominant treatment option.
C1 [Whitehead, Sarah J.] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Forest-Bendien, Veronique L.] KCI Europe Holding, Amstelveen, Netherlands.
   [Richard, Jean-Louis] Univ Nimes Hosp, Ctr Med, Serv Malad Nutr & Diabetol, Dept Nutr Dis & Diabetol, Nimes, France.
   [Halimi, Serge] CHU Grenoble, Univ Hosp Grenoble, Serv Endocrinol Diabetol Nutr, F-38043 Grenoble, France.
   [Van, Georges Ha] Clin Trois Soleils, Boissise Le Roi, France.
   [Trueman, Paul] Brunel Univ, Hlth Econ Res Grp, London, England.
C3 University of York - UK; Universite de Montpellier; CHU de Nimes; CHU
   Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); Brunel University
RP Whitehead, SJ (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, ARRC Bldg, York YO10 5DD, N Yorkshire, England.
EM sjw138@york.ac.uk
OI HA VAN, GEORGES/0000-0002-8024-8385
FU KCI Europe Holding (Amstelveen, the Netherlands)
FX Funding for this study was provided by KCI Europe Holding (Amstelveen,
   the Netherlands). VL Forest-Bendien, an employee of KCI Europe Holding,
   was involved in the data collection. This work is attributed to York
   Health Economics Consortium, University of York, UK. The V.A.C.(R)
   Therapy System and certain components and methods are subject to one or
   more of the following patents: USA: 5636643, 5645081, 6142982, 6345623,
   6553998, 6814079, 7004915, 7198046, 7216651; EU: EP777504, EP620720,
   EP865304, EP1088569, EP853950, EP1018967, EP1219311, EP1440667; other
   patents pending.
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NR 42
TC 15
Z9 19
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2011
VL 8
IS 1
BP 22
EP 32
DI 10.1111/j.1742-481X.2010.00739.x
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723OD
UT WOS:000287515200003
PM 20875048
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Petca, A
   Rotar, IC
   Borislavschi, A
   Petca, RC
   Danau, RA
   Dumitrascu, MC
   Sandru, F
   Pacu, I
AF Petca, Aida
   Rotar, Ioana Cristina
   Borislavschi, Andreea
   Petca, Razvan-Cosmin
   Danau, Razvan Alexandru
   Dumitrascu, Mihai Cristian
   Sandru, Florica
   Pacu, Irina
TI Adapting surgical 'bundles' to prevent surgical site infections in
   obstetrics and gynecology (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Review
DE surgical site infection; vacuum-assisted closure therapy; surgery;
   obstetrics; gynecology
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; SURGERY; REDUCE
AB Surgical site infections (SSIs) are a complication in any surgical field and they are responsible for 38% of surgery-related patient deaths. Identifying appropriate prophylaxis and solutions to combat SSIs is of global interest. Several studies and reports on SSI raise awareness of this costly complication, both in terms of physical and mental suffering, and as a monetary burden. Knowing the risk factors and implementing strategies to reduce SSI risk represent an adequate approach to reduce SSI incidence. General risk factors of SSI are applicable in the obstetrics and gynecology field, alongside its specific characteristics, including immunological changes occurring during pregnancy, as well as disturbances of vaginal microbiota. The risk of SSI is determined by patient factors but also by preoperative, intraoperative and postoperative care. 'Bundle' prevention strategies have been smartly adopted and their efficiency has been demonstrated in colorectal surgery, cesarean deliveries and gynecological oncology surgeries. 'Bundle' measures may vary among studies, but they remain important prevention methods, which contribute to decreasing SSIs, which is a favorable outcome, and thus, are increasingly used as a routine practice. Therefore, healthcare personnel should aim for the early identification of risk factors to minimize the risk of SSI. All evidence-based methods for preventing and treating SSIs in all surgical fields should be considered to be integral components in order for the best care to be provided to patients.
C1 [Petca, Aida; Dumitrascu, Mihai Cristian; Sandru, Florica; Pacu, Irina] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest 050474, Romania.
   [Petca, Aida; Borislavschi, Andreea] Elias Emergency Univ Hosp, Dept Obstet & Gynecol, Bucharest 011461, Romania.
   [Rotar, Ioana Cristina] Iuliu Hatieganu Univ Med & Pharm, Dept Obstet & Gynaecol 1, Cluj Napoca 400012, Romania.
   [Rotar, Ioana Cristina] Emergency Clin Cty Hosp Cluj Napoca, Dept Obstet & Gynecol, Cluj Napoca 400006, Romania.
   [Petca, Razvan-Cosmin; Danau, Razvan Alexandru] Carol Davila Univ Med & Pharm, Dept Urol, Bucharest 050474, Romania.
   [Petca, Razvan-Cosmin; Danau, Razvan Alexandru] Prof Dr Th BurgheleClin Hosp, Dept Urol, Bucharest 050659, Romania.
   [Dumitrascu, Mihai Cristian] Univ Emergency Hosp, Dept Obstet & Gynecol, Bucharest 050098, Romania.
   [Sandru, Florica] Elias Emergency Univ Hosp, Dept Dermatol, Bucharest 011461, Romania.
   [Pacu, Irina] Sf Pantelimon Emergency Clin Hosp, Dept Obstet & Gynecol, Bucharest 021623, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Carol Davila University of Medicine &
   Pharmacy
RP Borislavschi, A (通讯作者)，Elias Emergency Univ Hosp, Dept Obstet & Gynecol, Bucharest 011461, Romania.
EM andreeaborislavschi@gmail.com; razvan.danau@umfcd.ro
RI pacu, irina/E-8545-2019; rotar, ioana/AGD-1880-2022; Danau,
   Razvan/HJY-8563-2023; Borislavschi, Andreea/HMD-4904-2023; Sandru,
   Florica/JUV-4700-2023; Petca, Răzvan-Cosmin/AAH-2462-2020; Petca,
   Aida/AAM-9912-2020
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NR 48
TC 5
Z9 5
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2022
VL 24
IS 5
AR 695
DI 10.3892/etm.2022.11631
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5I3FW
UT WOS:000868247900001
PM 36277147
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ugaki, S
   Kasahara, S
   Arai, S
   Takagaki, M
   Sano, S
AF Ugaki, Shinya
   Kasahara, Shingo
   Arai, Sadahiko
   Takagaki, Masami
   Sano, Shunji
TI Combination of continuous irrigation and vacuum-assisted closure is
   effective for mediastinitis after cardiac surgery in small children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Mediastinitis; Pediatric; Congenital heart defects
AB There is still no consensus on the optimal management to treat pediatric mediastinitis. We assessed the efficacy of continuous irrigation and vacuum-assisted closure (VAC) for mediastinitis in children. This study retrospectively reviewed 20 patients aged <5 years with mediastinitis from December 2002 to December 2009. The median age at the onset was 12 months (0.6-60 months), and the median body weight was 6.9 kg (3.1-15.3 kg). Continuous irrigation was applied for extensive mediastinitis or unstable hemodynamic cases and VAC for localized or ineffective cases after continuous irrigation. A 2-4-week course of intravenous antibiotics was administered after sternal closure. Continuous irrigation was initially applied in 19 patients and VAC in one patient. VAC was employed in six patients because of recurrent or prolonged mediastinitis after continuous irrigation. All patients underwent direct sternal closure without any flap. The median duration of the hospital stay was 49.5 days (15-158 days). Although two patients died of low cardiac output, 18 children survived and had no recurrence after the discharge during a median follow-up of 14 months (1-81 months). The combination of continuous irrigation and VAC is, therefore, considered to be a safe and effective option to minimize the morbidity and mortality in pediatric mediastinitis. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Ugaki, Shinya; Kasahara, Shingo; Arai, Sadahiko; Takagaki, Masami; Sano, Shunji] Okayama Univ, Okayama Univ Hosp, Dept Cardiovasc Surg, Grad Sch Med & Dent, Okayama 7008558, Japan.
C3 Okayama University
RP Ugaki, S (通讯作者)，Okayama Univ, Okayama Univ Hosp, Dept Cardiovasc Surg, Grad Sch Med & Dent, 2-5-1 Shikata, Okayama 7008558, Japan.
EM uga-strah@hotmail.co.jp
RI Kasahara, Shingo/B-2207-2011
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NR 12
TC 18
Z9 20
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD SEP
PY 2010
VL 11
IS 3
BP 247
EP 251
DI 10.1510/icvts.2010.235903
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA V25MR
UT WOS:000208482600010
PM 20442210
OA Bronze
DA 2026-07-24
ER

PT J
AU Wackenfors, A
   Sjögren, J
   Algotsson, L
   Gustafsson, R
   Ingemansson, R
   Malmsjö, M
AF Wackenfors, A
   Sjögren, J
   Algotsson, L
   Gustafsson, R
   Ingemansson, R
   Malmsjö, M
TI The effect of vacuum-assisted closure therapy on the pig femoral artery
   vasomotor responses
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID CONGESTIVE-HEART-FAILURE; ENDOTHELIN-B-RECEPTOR; RAT MESENTERIC-ARTERY;
   CORONARY-ARTERIES; NITRIC-OXIDE; ANGIOTENSIN-II; BLOOD-VESSELS;
   ORGAN-CULTURE; WOUND CONTROL; UP-REGULATION
AB Vacuum-assisted closure (VAC) is frequently used to treat wound infections. The aim of the present study was to evaluate the effect of VAC therapy on blood vessels. Vasodilatation and vasoconstriction were studied in isolated ring segments of the pig femoral artery after continuous VAC therapy of an inguinal wound for 12 hours. Vasoconstriction induced by endothelin-1 (ET-1), which is mainly an endothelin type A receptor agonist (Emax = 181 +/- 2% of potassium), and the endothelin type B receptor agonist, sarafotoxin 6c (Emax = 30 +/- 1%), were significantly increased after VAC therapy (ET-1; 325 +/- 3% and sarafotoxin 6c; 69 +/- 1%). The norepinephrine-, phenylephrine-, and angiotensin II-induced vasoconstrictions were not affected by VAC therapy. Acetylcholine induced an endothelium-dependent dilatation that was enhanced after VAC therapy (Rmax = 38 +/- 1% of norepinephrine-preconstriction after sham and 47 +/- 1% after VAC therapy, p < 0.05). The dilatory response was mediated by nitric oxide (Rmax = 39 +/- 1%), prostaglandins (5 +/- 1%) and endothelium-derived hyperpolarizing factor (16 +/- 1%), which were all significantly increased after VAC therapy. In conclusion, VAC therapy for 12 hours enhances an endothelin type A and type B receptor-mediated vasoconstriction. This may be compensated for by a more efficacious endothelium-dependent vasodilatation. No spontaneous bleeding, perforation, dissection, or other macroscopic change could be observed in the arteries exposed to VAC therapy.
C1 Univ Lund Hosp, Div Expt Vasc Res, Dept Internal Med, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Anesthesia, SE-22184 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Wackenfors, A (通讯作者)，Univ Lund Hosp, Div Expt Vasc Res, Dept Internal Med, BMC A13, SE-22184 Lund, Sweden.
EM angelica.wackenfors@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; 
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NR 36
TC 24
Z9 32
U1 0
U2 1
PU BLACKWELL PUBLISHING INC
PI MALDEN
PA 350 MAIN ST, MALDEN, MA 02148 USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2004
VL 12
IS 2
BP 244
EP 251
DI 10.1111/j.1067-1927.2004.012117.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 812QA
UT WOS:000220852800015
PM 15086776
DA 2026-07-24
ER

PT J
AU Kotsis, T
   Lioupis, C
AF Kotsis, T.
   Lioupis, Chr.
TI Use of vacuum assisted closure in vascular graft infection confined to
   the groin
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE vacuum assisted closure; groin wounds; wound healing complications;
   vascular graft infection; lymphatic fistula
ID TOPICAL NEGATIVE-PRESSURE; ROTATIONAL MUSCLE FLAPS; LYMPHATIC FISTULA;
   WOUND THERAPY; MANAGEMENT; SURGERY; RECONSTRUCTION; COVERAGE; SALVAGE;
   BYPASS
AB Purpose : In this report we share our experience with the use of the VAC system as a less invasive means of graft preservation and an effective alternative to routine muscle flap closure, in patients with groin wound healing complications following lower limb vascular procedures. We also review the English literature regarding the use of VAC therapy on infected groin wounds when the infection affects the prosthesis.
   Patients and Methods : eight patients treated with delayed healing of a groin incision following a femoral artery surgery. In six cases local exploration or CT examination showed evidence of graft involvement (Szilagyi grade III).
   Results : Mean duration of VAC use was 21.5 days (range, 10 to 45). The wounds were filled with granulation tissue by day 10 with no purulent-inflammatory exudates. At the end of VAC therapy, final closure was easily achieved by either healing by secondary intention or delayed primary closure. No patient required use of muscle flaps. There were no reinfections at 1 to 28 month follow-up (mean, 17.2 months/ one case lost to follow-up).
   Conclusion : Our initial experience with VAC therapy to treat non healing groin wounds following vascular reconstructions is very promising. Negative pressure therapy resulted in control lymph leakage, achieving healing and managing infection.
C1 Univ Athens, Aretaeion Hosp, Sch Med, Surg Clin 2,Dept Vasc Surg, Athens, Greece.
   Red Cross Hosp Athens, Dept Vasc Surg, Athens, Greece.
C3 National & Kapodistrian University of Athens
RP Kotsis, T (通讯作者)，Univ Athens, Aretaeion Hosp, Sch Med, Surg Clin 2,Dept Vasc Surg, Vas Sophias 76, Athens, Greece.
EM kotsisth@otenet.gr
OI Lioupis, Christos/0000-0001-6197-3218
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NR 36
TC 24
Z9 28
U1 0
U2 2
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD FEB
PY 2007
VL 107
IS 1
BP 37
EP 44
DI 10.1080/00015458.2007.11680008
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 146TF
UT WOS:000244956900006
PM 17405596
DA 2026-07-24
ER

PT J
AU Akil, A
   Schnorr, P
   Wiebe, K
AF Akil, A.
   Schnorr, P.
   Wiebe, K.
TI Strategies for the treatment of postoperative sternal infections
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE sternal infection; sternal osteomyelitis; VAC (R) therapy; sternal
   resection; muscle flap
ID OPEN-HEART-SURGERY; CHEST-WALL RECONSTRUCTION; VACUUM-ASSISTED CLOSURE;
   MEDIAN STERNOTOMY; RISK-FACTORS; WOUND INFECTIONS; MEDIASTINITIS;
   COMPLICATIONS; RESECTION; DEHISCENCE
AB Postoperative sternal infections are associated with significant morbidity and mortality. An incidence of up to 8% has to be expected. Typically, a highly inflammatory acute infection with a marked soft tissue component is observed. However, the infection may also be present as a less symptomatic reaction and localised chronic osteomyelitis with fistula formation. The treatment strategy for a deep sternal wound infection consists of several steps. A radical debridement of the wound requires the opening of all abscesses, the resection of non-vital bone and the removal of all infected allomaterial. This is followed by a period of VAC therapy ( Vacuum-Assisted Closure Therapy) for infection treatment and conditioning of the wound. Secondary closure of the wound may be planned only after the infection is completely controlled. The sternum is stabilised by osteosynthesis. Sternal defects are covered. In most cases adequate soft tissue coverage is achieved by mobilisation of both pectoral muscles together with the precostal soft tissues. Following resection of the sternum, the reconstruction of the thoracic wall requires the implantation of material for stabilisation as well as soft tissue coverage. For complicated or large defects various muscle flaps and the omentum majus have been advocated. The latissimus dorsi muscle with skin is the muscle flap most frequently used.
C1 [Akil, A.; Schnorr, P.; Wiebe, K.] Univ Klinikum Munster, Sekt Thoraxchirurg, Herz & Thoraxchirurg, Albert Schweitzer Campus 1, D-48419 Munster, Germany.
C3 University of Munster
RP Wiebe, K (通讯作者)，Univ Klinikum Munster, Sekt Thoraxchirurg, Herz & Thoraxchirurg, Albert Schweitzer Campus 1, D-48419 Munster, Germany.
EM karsten.wiebe@ukmuenster.de
RI Schnorr, Philipp/GOE-5551-2022
OI Schnorr, Philipp/0000-0002-8853-9371; Akil, Ali/0000-0002-3748-1181
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NR 50
TC 1
Z9 6
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD FEB
PY 2016
VL 141
IS 1
BP 93
EP 101
DI 10.1055/s-0035-1558097
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DF1JH
UT WOS:000371095200023
PM 26492536
DA 2026-07-24
ER

PT J
AU Chant, H
   Woodrow, T
   Manley, J
AF Chant, H.
   Woodrow, T.
   Manley, J.
TI Autologous skin cells: a new technique for skin regeneration in diabetic
   and vascular ulcers
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; foot ulcer; autologous cell harvest
ID FOOT ULCERS; DISEASE; GRAFTS
AB Diabetic foot ulcers are often difficult to treat due to concurrent infection, neuropathy and vascular compromise. Healing adjuncts, such as negative pressure wound therapy and skin grafts, have been used with good results but eventual healing is often frustrated by slow epithelialisation. Here, we describe a novel therapeutic method to aid epithelial regeneration using autologous skin cells (ReCell; Avita Medical) to aid skin regeneration. We suggest this may provide an alternative to more established therapies used in this patient group.
C1 [Chant, H.; Woodrow, T.; Manley, J.] Royal Cornwall Hosp, Truro, Cornwall, England.
C3 Royal Cornwall Hospital
RP Chant, H (通讯作者)，Royal Cornwall Hosp, Truro, Cornwall, England.
EM jonathan.manley@rcht.nhs.uk
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   Brem H, 2000, ARCH SURG-CHICAGO, V135, P627, DOI 10.1001/archsurg.135.6.627
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NR 10
TC 13
Z9 14
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2013
VL 22
IS 10
SU S
BP S10
EP +
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 234XH
UT WOS:000325677100003
PM 24142135
DA 2026-07-24
ER

PT J
AU Thompson, E
AF Thompson, Elizabeth
TI Debridement Techniques and Non-Negative Pressure Wound Therapy Wound
   Management
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Wound healing; Debridement techniques; Chronic wounds; Granulation;
   Epithelialization
ID OCCLUSIVE DRESSINGS; LEECH THERAPY; ANTIBACTERIAL PROPERTIES;
   HYDROGEN-PEROXIDE; MAGGOT-THERAPY; COPPER COMPLEX; GROWTH-FACTORS;
   DOUBLE-BLIND; ALOE-VERA; IN-VITRO
AB The importance of initial wound classification and daily reevaluation of wound stage cannot be understated. Products available to enhance healing are categorized based on the stage of wound healing to which they exert their effects. After patient stability has been verified, thorough debridement is critical to create an environment conducive for healing. The wound environment of acute and chronic wounds differs greatly, often requiring different management approaches.
C1 [Thompson, Elizabeth] North Carolina State Univ, Coll Vet Med, Surg, 1060 William Moore Dr, Raleigh, NC 27606 USA.
C3 North Carolina State University
RP Thompson, E (通讯作者)，North Carolina State Univ, Coll Vet Med, Surg, 1060 William Moore Dr, Raleigh, NC 27606 USA.
EM emthomp6@ncsu.edu
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NR 116
TC 3
Z9 7
U1 0
U2 28
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD NOV
PY 2017
VL 47
IS 6
BP 1181
EP +
DI 10.1016/j.cvsm.2017.06.005
PG 23
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FM1GJ
UT WOS:000414721900006
PM 28781059
DA 2026-07-24
ER

PT J
AU Yoo, JJ
   Casey, LC
   Herweck, AM
   Thaller, SR
AF Yoo, Jason J.
   Casey, Liann C.
   Herweck, Alexandra M.
   Thaller, Seth R.
TI Alternative Therapies to Fat Grafting in the Craniofacial Region
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Editorial Material
DE Craniofacial; keloids; scars; wound healing
ID MESENCHYMAL STEM-CELLS; TOXIN TYPE-A; PULSED-DYE LASER; HYPERTROPHIC
   SCARS; INTRALESIONAL CRYOTHERAPY; BOTULINUM TOXIN; KELOID SCARS;
   HELIUM-NEON; SPLIT-SCAR; TRIAMCINOLONE
AB Autologous fat grafting is a technique with various applications in the craniofacial region ranging from the treatment of wounds, scars, keloids, and soft tissue deformities. In this review, alternative therapies to fat grafting are discussed. These are composed of established therapies like silicone gel or sheeting, corticosteroids, cryotherapy, and laser therapy. Novel applications of negative pressure wound therapy, botulinum toxin A injection, and biologic agents are also reviewed.
C1 [Yoo, Jason J.; Casey, Liann C.; Herweck, Alexandra M.; Thaller, Seth R.] Univ Miami, DeWitt Daughtry Family Dept Surg, Div Plast & Reconstruct Surg, Coral Gables, FL 33124 USA.
C3 University of Miami
RP Thaller, SR (通讯作者)，Univ Miami, DeWitt Daughtry Family Dept Surg, Div Plast & Reconstruct Surg, Coral Gables, FL 33124 USA.
EM sthaller@med.miami.edu
RI Yoo, Jason/JZT-5317-2024; Thaller, Seth/AAO-1801-2020
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NR 87
TC 5
Z9 5
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2019
VL 30
IS 3
BP 630
EP 635
DI 10.1097/SCS.0000000000005335
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HX9JR
UT WOS:000467724100047
PM 30817537
DA 2026-07-24
ER

PT J
AU Mazoch, M
   Montgomery, C
AF Mazoch, M.
   Montgomery, C.
TI Retained wound vacuum foam in non-healing wounds: a real possibility
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; wound vacuum sponge; retained vacuum
   sponge; foreign body; wound vac
ID ASSISTED CLOSURE
AB Negative pressure wound therpay (NPWT) has revolutionised the management of chronic wounds, particularly pressure ulcers (PU). Frequently, PUs are too large to close primarily, so NPWT is used to assist in management on an outpatient basis. If not closely monitored, NPWT closure foam can be accidentally left in patients. Here we describe two cases where NPWT closure foam was left in patients resulting in persistent infections. Additionally, some suggestions of how to help avoid these should be 'never' events are provided.
C1 [Mazoch, M.; Montgomery, C.] Univ Arkansas Med Sci, Dept Orthoped, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences
RP Mazoch, M (通讯作者)，Univ Arkansas Med Sci, Dept Orthoped, 4301 W Markham,Suite 531, Little Rock, AR 72205 USA.
EM MJMazoch@uams.edu
CR Beral D, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b2269
   Caniano DA, 2005, J PEDIATR SURG, V40, P128, DOI 10.1016/j.jpedsurg.2004.09.016
   Fox A, 2004, J Wound Care, V13, P344
   Friedman T, 2005, ANN PLAS SURG, V55, P420, DOI 10.1097/01.sap.0000174361.52084.6e
   Gawande AA, 2003, NEW ENGL J MED, V348, P229, DOI 10.1056/NEJMsa021721
   Gwan-Nulla DN, 2001, ANN PLAS SURG, V47, P552, DOI 10.1097/00000637-200111000-00014
   Saeed Musab U, 2007, Int J Low Extrem Wounds, V6, P153, DOI 10.1177/1534734607305597
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 8
TC 12
Z9 13
U1 1
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
SU S
BP S18
EP S20
DI 10.12968/jowc.2015.24.Sup6.S18
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PN
UT WOS:000355765800005
PM 26075511
DA 2026-07-24
ER

PT J
AU Billner, M
   Breidung, D
   Karcz, K
   Promny, D
   Ehrl, D
AF Billner, Moritz
   Breidung, David
   Karcz, Konrad
   Promny, Dominik
   Ehrl, Denis
TI From Liposuction to Reconstruction: Interdisciplinary Management of
   Necrotising Fasciitis after Outpatient Liposuction in a Non-Specialist
   Setting
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Article
DE freeflap; necrotising fasciitis; aesthetic surgery; freeflap;
   necrotising fasciitis; aesthetic surgery
AB This case report describes the clinical course of necrotising fasciitis as a serious complication following outpatient liposuction. The patient required extensive surgical procedures, including radical debridement, negative pressure wound therapy (NPWT) and multiple flaps to cover the extensive tissue defects, alongside prolonged intensive medical care. This case underscores the risks associated with aesthetic procedures and emphasises the importance of having such procedures performed exclusively by qualified and experienced specialists. This case also impressively demonstrates the importance of early diagnosis and interdisciplinary management.
C1 [Billner, Moritz; Breidung, David; Karcz, Konrad; Promny, Dominik; Ehrl, Denis] Paracelsus Med Privatuniv, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, Klinikum Nurnberg Sud,Univ Klin, Breslauer Str 201, D-90471 Nurnberg, Germany.
   [Promny, Dominik] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Erlangen, Germany.
   [Ehrl, Denis] Klinikum Univ Munchen, Abt Hand Plast & Asthet Chirurg, Munich, Germany.
C3 University of Erlangen Nuremberg; University of Munich
RP Billner, M (通讯作者)，Paracelsus Med Privatuniv, Zentrum Schwerbrandverletzte, Klin Plast Wiederherstellende & Handchirurg, Klinikum Nurnberg Sud,Univ Klin, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM moritz.billner@klinikum-nuernberg.de
OI Billner, Moritz/0000-0003-3614-9600
CR Aljerian A, 2024, PLAST SURG-CHIR PLAS, V32, P19, DOI 10.1177/22925503221078693
   [Anonymous], 2017, Journal of surgical case reports, P2017
   Breidung D, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000005773
   Choi JS, 2023, J PLAST RECONSTR AES, V80, P107, DOI 10.1016/j.bjps.2023.02.027
   Gawaziuk JP, 2017, BURNS, V43, P1561, DOI 10.1016/j.burns.2017.04.007
   Kaoutzanis C, 2017, AESTHET SURG J, V37, P680, DOI 10.1093/asj/sjw243
   Leibig N, 2014, SURG INFECT, V15, P850, DOI 10.1089/sur.2014.074
   Malghem J, 2013, JOINT BONE SPINE, V80, P146, DOI 10.1016/j.jbspin.2012.08.009
   Marchesi A, 2017, AESTHET PLAST SURG, V41, P352, DOI 10.1007/s00266-016-0754-2
   McDermott J, 2024, JAMA SURG, V159, P1308, DOI 10.1001/jamasurg.2024.3365
   Ruttkowski. VDAPC-Statistik, 2023, Zahlen, Fakten, Entwicklungen in der Asthetisch-Plastischen Chirurgie. VDAPC 2023
   Somasundaram J, 2021, BURNS, V47, P1608, DOI 10.1016/j.burns.2021.01.005
   von Glinski M, 2021, HANDCHIR MIKROCHIR P, V53, P312, DOI 10.1055/a-1381-8077
   Zargaran D, 2023, J PLAST RECONSTR AES, V86, P150, DOI 10.1016/j.bjps.2023.06.057
NR 14
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD AUG
PY 2025
VL 57
IS 04
BP 307
EP 311
DI 10.1055/a-2639-8914
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6BE2J
UT WOS:001549183900005
PM 40795866
DA 2026-07-24
ER

PT J
AU Loeck, J
   von Lücken, HJ
   Kehrl, W
   Loske, G
AF Loeck, J.
   von Luecken, H. -J.
   Kehrl, W.
   Loske, G.
TI Endoscopic negative pressure therapy of a post-laryngectomy
   pharyngocutaneous fistula-first report of a new therapeutic method.
   German version
SO HNO
LA German
DT Article
DE Respiratory tract fistula; Cutaneous fistula; Wound closure techniques;
   Negative-pressure wound therapy; Drainage
AB In the current first report, it is shown how a post-laryngectomy pharyngocutaneous fistula was successfully closed by endoscopic negative pressure therapy (ENPT; also termed endoscopic vacuum therapy, EVT). The duration of negative pressure treatment was 14 days. Up until now, ENPT has been used for treatment of transmural defects in the rectum and esophagus. The new endoscopic method can also be used in the ENT field for closure of pharyngocutaneous fistulas.
C1 [Loeck, J.; von Luecken, H. -J.; Kehrl, W.] Katholisches Marienkrankenhaus Hamburg gGmbH, Klin HNO Heilkunde Kopf Hals & Plast Gesichtschir, Hamburg, Germany.
   [Loske, G.] Katholisches Marienkrankenhaus Hamburg gGmbH, Allgemeinchirurg, Viszeralchirurg, Thoraxchirurg,Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital; St. Marien Hospital
RP Loske, G (通讯作者)，Katholisches Marienkrankenhaus Hamburg gGmbH, Allgemeinchirurg, Viszeralchirurg, Thoraxchirurg,Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM loske.chir@marienkrankenhaus.org
OI Loeck, Jonathan/0000-0002-7995-9550
CR Boscolo-Rizzo P, 2008, EUR ARCH OTO-RHINO-L, V265, P929, DOI 10.1007/s00405-007-0562-z
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Loske G, 2011, ENDOSCOPY, V43, P540, DOI 10.1055/s-0030-1256345
   Loske G, 2018, CHIRURG
   Loske G, 2018, ENDOSC INT OPEN, V6, pE865, DOI 10.1055/a-0599-5886
   Reiter M, 2013, AM J OTOLARYNG, V34, P411, DOI 10.1016/j.amjoto.2013.03.001
   Sayles M, 2014, LARYNGOSCOPE, V124, P1150, DOI 10.1002/lary.24448
   Wallstabe I, 2012, ENDOSCOPY, V44, pE49, DOI 10.1055/s-0031-1291525
NR 8
TC 0
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0017-6192
EI 1433-0458
J9 HNO
JI HNO
PD SEP
PY 2019
VL 67
IS 9
SI SI
BP 706
EP 709
DI 10.1007/s00106-019-0651-5
PG 4
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA IU6SM
UT WOS:000483716000017
PM 30968161
DA 2026-07-24
ER

PT J
AU Harding, K
AF Harding, Keith
TI INNOVATION AND WOUND HEALING
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE wound healing; innovation; chronic wounds
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; FIBRIN MATRIX; THERAPY; CARE; PROLIFERATION; MULTICENTER;
   GUIDELINES; DRESSINGS
AB Innovation in medicine requires unique partnerships between academic research, biotech or pharmaceutical companies, and health-care providers. While innovation in medicine has greatly increased over the past 100 years, innovation in wound care has been slow, despite the fact that chronic wounds are a global health challenge where there is a need for technical, process and social innovation. While novel partnerships between research and the health-care system have been created, we still have much to learn about wound care and the wound-healing processes.
C1 [Harding, Keith] Cardiff Univ, Sch Med, Clin Innovat, Cardiff CF10 3AX, S Glam, Wales.
   [Harding, Keith] Cardiff Univ, Sch Med, WHRU, Cardiff CF10 3AX, S Glam, Wales.
C3 Cardiff University; Cardiff University
RP Harding, K (通讯作者)，Cardiff Univ, Sch Med, Clin Innovat, Cardiff CF10 3AX, S Glam, Wales.
EM HardingKG@cardiff.ac.uk
RI Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
FU KCI, an Acelity company
FX KH presented as a faculty member during the 2014 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by KCI, an
   Acelity company. He is the guest editor for this educational supplement
   based on faculty presentations from the ISWF 2014. Acelity provided
   editorial assistance.
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NR 44
TC 17
Z9 22
U1 0
U2 46
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2015
VL 24
IS 4
SU S
BP 7
EP 13
DI 10.12968/jowc.2015.24.Sup4b.7
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG1YK
UT WOS:000353071900002
PM 25853643
DA 2026-07-24
ER

PT J
AU Krahwinkel, DJ
   Boothe, HW
AF Krahwinkel, D. J.
   Boothe, Harry W., Jr.
TI Topical and systemic medications for wounds
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COPPER COMPLEX; DRESSINGS; DEBRIDEMENT;
   THERAPY; CHLORHEXIDINE; MICROBIOLOGY; STIMULATION; MANAGEMENT;
   RESISTANCE
AB There are a plethora of topical and systemic medications available to the veterinary practitioner today that aid the wound healing process. Some of these help to maintain a moist environment. Others increase growth factors, provide local energy sources, control infection, provide for debridement, increase wound blood flow and temperature, or reduce wound edema. Modern wound care requires that the proper products (s) be used, depending on the condition of the wound and the phase of wound healing. This article discusses various wound care products and provides guidelines on their use.
C1 Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, Vet Teaching Hosp C247, Knoxville, TN 37996 USA.
   Auburn Univ, Coll Vet Med, Dept Clin Sci, Auburn, AL 36849 USA.
C3 University of Tennessee System; University of Tennessee Knoxville; UT
   Institute of Agriculture; Auburn University System; Auburn University
RP Krahwinkel, DJ (通讯作者)，Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, Vet Teaching Hosp C247, Knoxville, TN 37996 USA.
EM djk@utk.edu
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NR 64
TC 24
Z9 35
U1 0
U2 32
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD JUL
PY 2006
VL 36
IS 4
BP 739
EP +
DI 10.1016/j.cvsm.2006.04.001
PG 20
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 064ZR
UT WOS:000239129700006
PM 16787786
DA 2026-07-24
ER

PT J
AU Mostow, EN
AF Mostow, EN
TI Wound healing - A multidisciplinary approach for dermatologists
SO DERMATOLOGIC CLINICS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SMALL-INTESTINAL SUBMUCOSA; MAGGOT DEBRIDEMENT
   THERAPY; DIABETIC FOOT ULCERS; VENOUS STASIS ULCERS; PRESSURE SORES;
   PYODERMA-GANGRENOSUM; LEG ULCERS; PERIPHERAL NEUROPATHY; RANDOMIZED
   TRIAL
AB This article reviews common and some less common approaches to wound healing. Chronic wound healing is one of the more challenging areas of medicine, with a nice balance of the science and art of medicine. An evidence-based, patient-centered approach can be used to effectively improve the care of many difficult-to-heal ulcers in often frustrated patients. The multidisciplinary wound clinic concept can help improve the outcomes of patients with leg ulcers.
C1 Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA.
   Northeastern Ohio Univ Coll Med & Pharm, Coll Med, Rootstown, OH 44272 USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Northeast Ohio Medical University (NEOMED)
RP Mostow, EN (通讯作者)，157 W Cedar St,Suite 101, Akron, OH 44307 USA.
EM emostow@neoucom.edu
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NR 115
TC 9
Z9 9
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0733-8635
EI 1558-0520
J9 DERMATOL CLIN
JI Dermatol. Clin.
PD APR
PY 2003
VL 21
IS 2
BP 371
EP +
DI 10.1016/S0733-8635(02)00100-6
PG 18
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 674DK
UT WOS:000182621600016
PM 12757258
DA 2026-07-24
ER

PT J
AU Schimmer, C
   Keith, P
   Neukam, K
   Beissert, M
   Leyh, R
AF Schimmer, C.
   Keith, P.
   Neukam, K.
   Beissert, M.
   Leyh, R.
TI Large thoracic wall hematoma following sternal reconstruction with
   transversa plate fixation after deep sterna wound infection
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE deep sternal wound infection; transverse plate fixation; hematoma;
   complications
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS
AB We present the Case of a 53-year-old male patient with a rare complication of a thoracic wall hematoma following thoracic wall reconstruction with transverse plate fixation and pectoralis advancement flaps. The patient could be subsequently discharged after surgical re-treatment and an uneventful wound healing. This case marks one of two complications occurring in a series of six patients treated for deep sternal wound infection with a combination of vacuum-assisted therapy and plate fixation.
C1 Univ Wurzburg, Dept Heart Surg, D-97080 Wurzburg, Germany.
   Univ Wurzburg, Dept Radiol, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Schimmer, C (通讯作者)，Univ Wurzburg, Dept Heart Surg, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany.
EM Schimmer_c@klinik.uni-wuerzburg.de
CR Cicilioni OJ, 2005, PLAST RECONSTR SURG, V115, P1297, DOI 10.1097/01.PRS.0000156918.15595.85
   Molina JE, 2006, J THORAC CARDIOV SUR, V132, P782, DOI 10.1016/j.jtcvs.2006.06.008
   Pai S, 2005, ANN THORAC SURG, V80, P962, DOI 10.1016/j.athoracsur.2005.03.089
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   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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NR 8
TC 4
Z9 7
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD SEP
PY 2007
VL 55
IS 6
BP 402
EP 405
DI 10.1055/s-2007-965402
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 213GK
UT WOS:000249654700015
PM 17721856
DA 2026-07-24
ER

PT J
AU Kopp, J
   Bach, AD
   Kneser, U
   Polykandriotis, E
   Loos, B
   Krickhahn, M
   Jeschke, MG
   Horch, RE
AF Kopp, J
   Bach, AD
   Kneser, U
   Polykandriotis, E
   Loos, B
   Krickhahn, M
   Jeschke, MG
   Horch, RE
TI Indication and clinical results of buried skin grafting to treat
   problematic wounds
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE wound healing; skin grafting; vacuum therapy
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR RECONSTRUCTION; PERIANAL BURNS
AB In 1920 Braun described a technique of skin grafting particularly designed for areas where shearing forces, high pressure and extensive secretion cause repetitive loss of conventionally transplanted skin. During the last 10 years we successfully used this technique when impaired wound healing was encountered due to various reasons. Clinical examples of application and results are presented. By combining this technique with vacuum therapy, formation of granulation tissue can be accelerated, thereby resulting in successful trans plantation of problematic and therapy resistant wounds.
C1 Univ Klinikum Erlangen, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kopp, J (通讯作者)，Univ Klinikum Erlangen, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM juergen.kopp@chir.imed.uni-erlangen.de
RI Jeschke, Marc/D-3501-2019; Horch, Raymund/H-8128-2019
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NR 26
TC 2
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S129
EP S132
DI 10.1055/s-2004-822649
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600040
PM 15168310
DA 2026-07-24
ER

PT J
AU Künzel, RA
   Marathovouniotis, N
   Kellner, MW
   Boemers, TM
AF Kuenzel, R. A.
   Marathovouniotis, N.
   Kellner, M. W.
   Boemers, T. M.
TI Severe degloving injury to both feet in a child
SO UNFALLCHIRURG
LA German
DT Article
DE Degloving; Avulsion injury; Traumatology; Full-thickness graft;
   Vacuum-assisted closure therapy
ID SKIN AVULSION INJURIES; CLASSIFICATION; OPTIONS; LIMBS
AB Although rarely described, it is generally accepted that degloving injuries can successfully be treated by defatting the degloved skin and replacing it with a full-thickness graft. There have been few reports on the outcome of this reconstructive procedure in children. In this report, we describe the use of the VAC system to treat a case of degloving injury to both feet of a 4-year-old boy who was pulled into a luggage belt while standing on it.
C1 [Kuenzel, R. A.; Marathovouniotis, N.; Boemers, T. M.] Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Klin Kinderchirurg & Kinderurol, D-50735 Cologne, Germany.
   [Kellner, M. W.] Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Abt Kinderradiol, D-50735 Cologne, Germany.
C3 University of Cologne; University of Cologne
RP Künzel, RA (通讯作者)，Kliniken Stadt Koln GmbH, Kinderkrankenhaus Amsterdamer Str, Klin Kinderchirurg & Kinderurol, Amsterdamer Str 59, D-50735 Cologne, Germany.
EM kuenzelr@kliniken-koeln.de
CR [Anonymous], 2009, J TRAUMA
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
J9 UNFALLCHIRURG
JI Unfallchirurg
PD FEB
PY 2013
VL 116
IS 2
BP 171
EP 175
DI 10.1007/s00113-012-2163-6
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 088LK
UT WOS:000314835700012
PM 22699318
DA 2026-07-24
ER

PT J
AU Adams, SB
   Sabesan, VJ
   Easley, ME
AF Adams, Samuel B., Jr.
   Sabesan, Vani J.
   Easley, Mark E.
TI Wound Healing Agents
SO CRITICAL CARE NURSING CLINICS OF NORTH AMERICA
LA English
DT Article
DE Wound healing; Diabetes; Hyperbaric oxygen; Impregnated gauze;
   Hydrocolloids
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; FOOT; INFECTION; ULCERS
AB Wound Healing Agents Samuel B. Adams Jr, Vani J. Sabesan, and Mark E. Easley When not treated properly, wounds of the foot and ankle can be devastating for both patient and physician. A multitude of wound healing agents are available, with some correlation to the type of wound or underlying disease, but for the most part the use of these agents is based on inherited common practice, personal preference, or marketing activities. This article reviews some of the most common products used as adjuncts to the healing process.
C1 [Adams, Samuel B., Jr.; Sabesan, Vani J.; Easley, Mark E.] Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC 27710 USA.
C3 Duke University
RP Easley, ME (通讯作者)，Duke Univ, Med Ctr, Div Orthopaed Surg, Box 2950, Durham, NC 27710 USA.
EM easle004@mc.duke.edu
OI Adams, Samuel/0000-0003-1020-1167
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NR 15
TC 4
Z9 4
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0899-5885
J9 CRIT CARE NURS CLIN
JI Crit. Care Nurs. Clin. N. Am.
PD JUN
PY 2012
VL 24
IS 2
BP 255
EP +
DI 10.1016/j.cce11.2012.03.010
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 068VV
UT WOS:000313395200007
PM 22548862
DA 2026-07-24
ER

PT J
AU Fonder, MA
   Lazarus, GS
   Cowan, DA
   Aronson-Cook, B
   Kohli, AR
   Mamelak, AJ
AF Fonder, Margaret A.
   Lazarus, Gerald S.
   Cowan, David A.
   Aronson-Cook, Barbara
   Kohli, Angela R.
   Mamelak, Adam J.
TI Treating the chronic wound: A practical approach to the care of
   nonhealing wounds and wound care dressings
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS; DIABETIC FOOT ULCERS;
   TOPICAL ZINC-OXIDE; GROWTH FACTOR-BB; IN-VITRO; PYODERMA-GANGRENOSUM;
   CALCIUM ALGINATE; HYPERBARIC-OXYGEN; CADEXOMER IODINE
AB Chronic wounds are a major healthcare problem costing the United States billions of dollars a year. The American Academy of Dermatology has underscored the significance of wound care in dermatological practice. It is critical for all dermatologists to understand the elements of diagnosis and therapy. We emphasize major aspects of diagnosis and present a simple classification of wound dressings with guidelines for usage and relative cost data.
C1 [Fonder, Margaret A.; Lazarus, Gerald S.; Cowan, David A.; Aronson-Cook, Barbara; Kohli, Angela R.; Mamelak, Adam J.] Johns Hopkins Univ, Dept Dermatol, Baltimore, MD 21218 USA.
C3 Johns Hopkins University
RP Lazarus, GS (通讯作者)，Johns Hopkins Bayview Med Ctr, Dept Dermatol, MFL Ctr Tower,Suite 2500,5200 Eastern Ave, Baltimore, MD 21224 USA.
EM glazaru1@jhmi.edu
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   EDGEPARK SURGICAL CA
NR 205
TC 497
Z9 627
U1 0
U2 185
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD FEB
PY 2008
VL 58
IS 2
BP 185
EP 206
DI 10.1016/j.jaad.2007.08.048
PG 22
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 253HJ
UT WOS:000252509000001
PM 18222318
DA 2026-07-24
ER

PT J
AU Trueman, P
AF Trueman, Paul
TI Cost-effectiveness considerations for home health VAC® Therapy in the
   United States of America and its potential international application
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Economics; Home health; VAC Therapy
AB Vacuum-assisted closure (V.A.C.(R)) Therapy (KCI International, San Antonio, TX) has been widely used in hospital settings. However, use of V.A.C.(R) Therapy in home health settings outside of the United States of America (USA) is often limited because of financial considerations. This review paper considers the published evidence on V.A.C. Therapy in home health settings from the USA and beyond and explores the potential economic implications of V.A.C. Therapy in home health settings.
C1 Univ York, Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
C3 University of York - UK
RP Trueman, P (通讯作者)，Univ York, Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
EM pt507@york.ac.uk
FU KCI International
FX The author's department has previously received funding from KCI
   International to undertake research on V. A. C. Therapy. PT has not
   benefited personally from any funding from KCI International.
CR *DIAB FOOT INT DIA, POS STAT DIAB FOOT A
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   HAUSER T, 2007, ANN C GLASG EUR WOUN
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
   XAKELLIS GC, COST HEALING PRESSUR
NR 12
TC 11
Z9 12
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 23
EP 26
DI 10.1111/j.1742-481X.2008.00468.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600005
PM 18577135
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lane, C
   Lin, A
   Goyal, N
AF Lane, Ciaran
   Lin, Alice
   Goyal, Neerav
TI Scalp and Calvarium Reconstruction
SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Scalp reconstruction; Calvarium reconstruction; Microvascular
   reconstruction; Plastic surgery; Cranioplasty
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR HEAD; SKIN; CRANIOPLASTY;
   DEFECTS; WOUNDS; BONE; FLAP
AB Scalp and calvarium reconstruction encompass the full spectrum of the reconstructive ladder. This region is anatomically challenging to reconstruct due to its thin nature, mechanical properties, and distance from large vessels. The reconstructive popula-tions are commonly elderly, previously radiated, and have poor healing potential. A thorough patient evaluation is necessary to understand a patient's reconstruction goals. The reconstructive surgeon should consider a variety of reconstructive options and select the simplest reconstructive approach, which meets the patient's goals.
C1 [Lane, Ciaran; Goyal, Neerav] Penn State Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, 500 Univ Drive MC H091, Hershey, PA 17033 USA.
   [Lin, Alice] Kaiser Permanente Sch Med, Dept Clin Sci, 4900 Sunset Blvd 6th Floor, Los Angeles, CA 90027 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Lane, C (通讯作者)，Penn State Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, 500 Univ Drive MC H091, Hershey, PA 17033 USA.
EM lanec345@myumanitoba.ca
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   Gabrysz-Forget F, 2019, J OTOLARYNGOL-HEAD N, V48, DOI 10.1186/s40463-019-0334-y
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   Kannan S, 2016, DERMATOL SURG, V42, P1248, DOI 10.1097/DSS.0000000000000890
   Kim PD, 2007, ARCH OTOLARYNGOL, V133, P791, DOI 10.1001/archotol.133.8.791
   Kosutic D, 2012, BURNS, V38, P143, DOI 10.1016/j.burns.2011.08.019
   Liu LM, 2020, BRIT J NEUROSURG, V34, P388, DOI 10.1080/02688697.2020.1742291
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   van de Vijfeijken SECM, 2018, WORLD NEUROSURG, V117, P443, DOI 10.1016/j.wneu.2018.05.193
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NR 30
TC 7
Z9 9
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-6665
EI 1557-8259
J9 OTOLARYNG CLIN N AM
JI Otolaryngol. Clin. N. Am.
PD AUG
PY 2023
VL 56
IS 4
BP 741
EP 755
DI 10.1016/j.otc.2023.04.003
EA JUN 2023
PG 15
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA N7VV7
UT WOS:001039054100001
PM 37217365
DA 2026-07-24
ER

PT J
AU Acartürk, TO
AF Acarturk, Tahsin Oguz
TI Reconstruction of lower extremity close-range shotgun injuries with
   gracilis free flap: a report of two cases
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Close range shotgun; gracilis free flap; lower extremity trauma
ID WOUND BALLISTICS; MUSCLE; DEFECTS
AB Close-range shotgun injury to the lower extremity is a devastating problem and is a challenge to the surgeon. Point-blank shotgun injuries to the extremities create a typical wound that is deep but not wide. These wounds almost always need to be treated with local or distant tissue transfer. We report two cases of shotgun injury to the lower extremity at point-blank range, which were treated using debridement, vacuum-assisted closure and free gracilis muscle flap transfer.
C1 Cukurova Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Adana, Turkey.
C3 Cukurova University
RP Acartürk, TO (通讯作者)，Cukurova Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, PK 1275 Gar, Adana, Turkey.
EM toacarturk@yahoo.com
RI Acarturk, Tahsin/MIT-6667-2025
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   Çeliköz B, 2005, MICROSURG, V25, P3, DOI 10.1002/micr.20049
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NR 11
TC 3
Z9 4
U1 0
U2 1
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JUL
PY 2010
VL 16
IS 4
BP 367
EP 370
PG 4
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 636TI
UT WOS:000280763500016
PM 20849057
DA 2026-07-24
ER

PT J
AU Gwan-Nulla, DN
   Casal, RS
AF Gwan-Nulla, DN
   Casal, RS
TI Toxic shock syndrome associated with the use of the vacuum-assisted
   closure device
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
AB The vacuum-assisted wound closure technique and device (the V.A.C.) has become a widely accepted technique in the management of chronic and difficult wounds. The authors present the first reported case of toxic shock syndrome associated with its use. This article does not question the efficacy of the V.A.C. technique in the treatment of difficult wounds, but focuses on raising the index of suspicion of toxic shock syndrome in patients with wounds managed with the V.A.C. who develop early signs or symptoms that may be consistent with the diagnosis.
C1 Penn State Univ, Milton S Hershey Med Ctr, Dept Surg, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Gwan-Nulla, DN (通讯作者)，Div Cardiothorac Surg, Harper Profess Bldg,Suite 2102,3990 John R, Detroit, MI 48201 USA.
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NR 9
TC 68
Z9 105
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD NOV
PY 2001
VL 47
IS 5
BP 552
EP 554
DI 10.1097/00000637-200111000-00014
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 491JK
UT WOS:000172105100014
PM 11716269
DA 2026-07-24
ER

PT J
AU Boll, G
   Callas, P
   Bertges, DJ
AF Boll, Griffin
   Callas, Peter
   Bertges, Daniel J.
TI Meta-analysis of prophylactic closed-incision negative pressure wound
   therapy for vascular surgery groin wounds
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the New-England-Society-for-Vascular-Surgery
CY SEP 15-OCT 17, 2021
CL Cape Neddick, ME
DE Negative pressure wound therapy; Surgical site infections; Wound
   complications
ID SURGICAL-SITE INFECTION; VEIN BYPASS; COMPLICATIONS; PREVENTION;
   PREDICTORS; SOCIETY; TRIALS; GENDER; IMPACT
AB Objective: A previous meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of closed incision negative pressure wound therapy (ciNPWT) on vascular surgery groin wounds reported a reduction in surgical site infections (SSIs). Our aim was to perform a comprehensive, updated meta-analysis after the largest multicenter RCT on the subject to date reported no benefits from ciNPWT.
   Methods: A systematic review identified RCTs that had compared the primary outcome of the incidence of postoperative SSIs of groin incisions treated with ciNPWT or standard dressings. The secondary outcomes included wound dehiscence, a composite incidence of seroma, lymph leakage, and hematoma, the need for reoperation, in-hospital mortality, the need for readmission, and the hospital length of stay. The odds ratios (ORs) were compared across the studies using a random effects meta-analysis. The risk of bias was assessed using the Cochrane risk of bias tool, Harbord test, and trim-and-fill analysis.
   Results: Eight RCTs with 1125 incisions (ciNPWT, n = 555 [49.3%]; control, n = 570 [50.7%]) were included. The RCTs included three studies inside and five outside the United States. ciNPWT was associated with a significant reduction in the rate of SSIs (OR, 0.39; 95% confidence interval [CI], 0.24-0.63; P < .001). No significant differences were found in the rate of wound dehiscence (OR, 1.11; 95% CI, 0.67-1.83; P = .68), composite incidence of seroma, lymph leak, or hematoma (OR, 0.49; 95% CI, 0.13-1.76; P = .27), need for reoperation (OR, 0.68; 95% CI, 0.40-1.16; P = .16), or need for readmission (OR, 0.60; 95% CI, 0.30-1.21; P = .15). It was not possible to quantitatively evaluate in-hospital mortality or the hospital length of stay. The risk of bias assessment identified a high risk of bias for participant blinding in all eight studies, a low risk for randomization and outcome reporting, and variability between studies for the other methods. We found no evidence of publication bias.
   Conclusions: Our meta-analysis of pooled data has suggested that prophylactic use of ciNPWT for vascular groin incisions will be associated with reduced rates of SSIs. The greatest benefits were seen in the trials with higher baseline rates of SSIs in the control group.
C1 [Boll, Griffin; Bertges, Daniel J.] Univ Vermont, Dept Surg, Med Ctr, 111 Colchester Ave, Burlington, VT 05401 USA.
   [Callas, Peter] Univ Vermont, Dept Med Biostat, Burlington, VT 05401 USA.
C3 University of Vermont Medical Center; University of Vermont; University
   of Vermont
RP Bertges, DJ (通讯作者)，Univ Vermont, Dept Surg, Med Ctr, 111 Colchester Ave, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
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   Coomer NM, 2016, AM J INFECT CONTROL, V44, P1326, DOI 10.1016/j.ajic.2016.03.025
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   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
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   Dua A, 2014, J VASC SURG, V60, P1635, DOI 10.1016/j.jvs.2014.08.072
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   Sexton F, 2020, INT J SURG, V76, P94, DOI 10.1016/j.ijsu.2020.02.037
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
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NR 31
TC 27
Z9 28
U1 3
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUN
PY 2022
VL 75
IS 6
BP 2086
EP +
DI 10.1016/j.jvs.2021.12.070
EA MAY 2022
PG 17
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 1K0NF
UT WOS:000798307600036
PM 34999218
OA Bronze
DA 2026-07-24
ER

PT J
AU Rickert, M
   Rauschmann, M
   Latif-Richter, N
   Arabmotlagh, M
   Rahim, T
   Schmidt, S
   Fleege, C
AF Rickert, Marcus
   Rauschmann, Michael
   Latif-Richter, Nizar
   Arabmotlagh, Mohammad
   Rahim, Tamin
   Schmidt, Sven
   Fleege, Christoph
TI Management of Deep Spinal Wound Infections Following Instrumentation
   Surgery with Subfascial Negative Pressure Wound Therapy
SO JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
LA English
DT Article
DE spinal surgery; infection risk factors; postoperative wound infection;
   negative pressure wound therapy
ID SURGICAL SITE INFECTIONS; RISK-FACTORS; NOSOCOMIAL INFECTIONS; LUMBAR
   FUSION; DIAGNOSIS; GERMANY; CLOSURE; PREVALENCE; ADULTS
AB Background and Study Aims The treatment of infections following a spine surgery continues to be a challenge. Negative pressure wound therapy (NPWT) has been an effective method in the context of infection therapy, and its use has gained popularity in recent decades. This study aims to analyze the impact of known risk factors for postoperative wound infection on the efficiency and length of NPWT therapy until healing.
   Patients and Methods We analyzed 50 cases of NPWT treatment for deep wound infection after posterior and posteroanterior spinal fusion from March 2010 to July 2014 retrospectively. We included 32 women and 18 men with a mean age of 69 years (range, 36-87 years). Individual risk factors for postoperative infection, such as age, gender, obesity, diabetes, immunosuppression, duration of surgery, intraoperative blood loss, and previous surgeries, as well as type and onset (early vs. late) of the infection were analyzed. We assessed the associations between these risk factors and the number of revisions until wound healing.
   Results In 42 patients (84%), bacterial pathogens were successfully detected by means of intraoperative swabs and tissue samples during first revision. A total of 19 different pathogens could be identified with a preponderance of Staphylococcus epidermidis (21.4%) and S. aureus (19.0%). Methicillin-resistant S. aureus (MRSA) was recorded in two patients (2.6%). An average of four NPWT revisions was required until the infection was cured. Patients with infections caused by mixed pathogens required a significantly higher number of revisions (5.3 vs. 3.3; p <0.01) until definitive wound healing. For the risk factors, no significant differences in the number of revisions could be demonstrated when compared with the patients without the respective risk factor.
   Conclusion NPWT was an effective therapy for the treatment of wound infections after spinal fusion. All patients in the study had their infections successfully cured, and all spinal implants could be retained. The number of revisions was similar to those reported in the published literature. The present study provides insights regarding the effectiveness of NPWT for the treatment of deep wound infection after spinal fusion. Further investigations on the impact of potential risk factors for postoperative wound healing disorders are required. Better knowledge on the impact of specific risk factors will contribute to a higher effectiveness of prophylaxis for postoperative wound infections considering the patient-specific situation.
C1 [Rickert, Marcus] Schon Klin Lorsch, Spine Dept, Wilhelm Leuschner Str 10, D-64653 Lorsch, Germany.
   [Rauschmann, Michael; Arabmotlagh, Mohammad; Schmidt, Sven] Sana Klinikum Offenbach GmbH, Wirbelsaulenorthopadie & Rekonstrukt Orthopadie, Offenbach, Hessen, Germany.
   [Latif-Richter, Nizar; Fleege, Christoph] Orthopad Univ Klin Friedrichsheim gGmbH, Dept Orthoped, Frankfurt, Hessen, Germany.
   [Rahim, Tamin] Neurosurg Wiesbaden, Dept Neurosurg, Wiesbaden, Germany.
C3 Sana Klinikum Offenbach
RP Rickert, M (通讯作者)，Schon Klin Lorsch, Spine Dept, Wilhelm Leuschner Str 10, D-64653 Lorsch, Germany.
EM marcusrickert@gmx.de
OI Arabmotlagh, Mohammad/0000-0002-7648-7412
CR [Anonymous], 2018, J Spec Oper Med, DOI DOI 10.55460/Z90F-IPF2
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NR 43
TC 5
Z9 8
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 2193-6315
EI 2193-6323
J9 J NEUROL SURG PART A
JI J. Neurol. Surg. Part A
PD JAN
PY 2023
VL 84
IS 01
BP 30
EP 36
DI 10.1055/s-0040-1720999
EA JAN 2021
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7W2VH
UT WOS:000612195700001
PM 33506474
DA 2026-07-24
ER

PT J
AU Wang, C
   Zhang, JX
   Liu, ZZ
AF Wang, Chao
   Zhang, Jixun
   Liu, Zhenzhong
TI Stool Management Followed by Surgical Debridement and Surgical Closure
   Combined With Negative Pressure Wound Therapy in the Treatment of
   Posterior Trunk Pressure Injury: A Retrospective Descriptive Study
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE pressure injury; negative pressure wound therapy; infection; stool
   management; retrospective descriptive study
ID PARENTERAL-NUTRITION; ULCERS; RISK; COMPLICATIONS; PREVENTION; SUPPORT;
   IMPACT; DEVICE
AB BACKGROUND: Pressure injuries are a burden to patients and the health care system, and negative pressure wound therapy (NPWT) is a widely used treatment. PURPOSE: This study sought to assess the effect of stool management followed by surgi-cal debridement and surgical closure combined with NPWT in the treatment of posterior trunk pressure injuries. METHODS: A retrospective descriptive study was conducted in patients with stage 3 or 4 posterior trunk pressure injuries by reviewing electronic health records. The collected variables included sex, age, height, weight, initial underlying disease leading to being bedridden, stage and anatomical location of pressure injury, stool frequency, pathogens, number of NPWT applications, com-plications related to surgical closure, outcome, and treatment time. Fasting and enema were used to reduce the frequency of defecation, followed by surgical debridement and surgical closure combined with NPWT. RESULTS: Among the 63 eligible pa-tients, 35 were male and 28 were female (average age, 72.3 +/- 11.3 years). The patients' weight before fasting and after fasting showed no significant difference (62.6 +/- 11.2 kg vs 61.6 +/- 10.2 kg; 95% confidence interval, -2.78-4.76; P = .60). Stage 3 and stage 4 accounted for 33 (52.4%) and 30 (47.6%) pressure injuries, respectively. There were 36 (57.1%) pressure injuries located on the sacrum, and the remaining 27 (42.9%) were located in the ischia. Underlying causes for being bedridden were cardiopulmonary insufficiency (n = 23; 36.5%), severe brain damage and cerebrovascular accident (n = 19; 30.2%), spinal cord injury (n = 12; 19.0%), and others (14.3%). The wound closure rate was 96.8% (n = 61), with a mean hospital stay of 22.3 days. These patients underwent 1 to 3 cycles of NPWT before surgical wound closure. Escherichia coli, Staphylococ-cus aureus, and Pseudomonas aeruginosa were the most common pathogens. The complications related to surgical closure (defined as complications that occurred from surgical closure until 30 days later) occurred in 7 patients (11.1%); 3 patients (4.8%) experienced a pressure injury recurrence. CONCLUSION: The treatment approach reported here was effective in these patients with posterior trunk pressure injuries. A satisfactory cure rate, manageable complications, and rare recurrence were achieved. Parenteral nutrition after fasting maintained patients' weight without significant loss. Prospective randomized controlled trials involving larger samples and longer follow-up times are needed
C1 [Wang, Chao; Zhang, Jixun; Liu, Zhenzhong] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
   [Wang, Chao] Shandong Univ, Cheeloo Coll Med, Jinan, Peoples R China.
C3 Shandong University; Shandong University
RP Liu, ZZ (通讯作者)，Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Burn & Plast Surg, Jinan 250033, Shandong, Peoples R China.
EM drliuzhenzhong@163.com
CR [Anonymous], 2019, The International Guideline
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NR 44
TC 1
Z9 1
U1 0
U2 8
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD APR
PY 2022
VL 68
IS 4
BP 26
EP 33
DI 10.25270/wmp.2022.4.2633
PG 8
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA 1Q6LQ
UT WOS:000802796700002
PM 35544779
DA 2026-07-24
ER

PT J
AU Kojima, K
   Goto, M
   Nagashima, Y
   Saito, Y
   Kawai, M
   Takebe, S
   Egawa, A
   Tanba, M
   Ishikawa, K
   Matsuoka, H
   Masaki, T
   Sunami, E
   Ohura, N
   Teruya, K
   Eto, K
   Nozawa, K
   Sakamoto, K
   Funahashi, K
AF Kojima, Koichiro
   Goto, Mayu
   Nagashima, Yasuo
   Saito, Yoko
   Kawai, Masaya
   Takebe, Shihori
   Egawa, Akiko
   Tanba, Mitsuko
   Ishikawa, Kazue
   Matsuoka, Hiroyoshi
   Masaki, Tadahiko
   Sunami, Eiji
   Ohura, Norihiko
   Teruya, Koji
   Eto, Ken
   Nozawa, Keijiro
   Sakamoto, Kazuhiro
   Funahashi, Kimihiko
TI Effectiveness of negative pressure wound therapy for the wound of
   ileostomy closure: a multicenter, phase II randomized controlled trial
SO BMC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Ileostomy closure; Wound healing;
   Surgical site infection; Purse-string suture; Randomized controlled
   trial; Phase II trial
ID SURGICAL SITE INFECTION; SKIN CLOSURE
AB Background The American Society of Surgery and American Society for Surgical Infections issued guidelines for surgical site infections (SSIs) in December 2016. These guidelines recommend a purse-string suture (PSS) for stoma closure as it facilitates granulation and enables open wound drainage. This study investigated the effect of using negative pressure wound therapy (NPWT) along with standard PSS and aimed to determine the optimal period of NPWT use. Methods The patients were divided into three groups as follows: Group A, postoperative wound management alone with gauze exchange as the representative of conventional PSS; Group B, the performed management was similar to that of Group A plus NPWT for 1 week; and Group C, the performed management was similar to that of Group A plus NPWT for 2 weeks. Regarding objective measures, the wound reduction rate was the primary outcome, and the incidence of SSIs, length of hospital stay, and wound healing duration were the secondary outcomes. Results In total, 30 patients (male: 18, female: 12) were enrolled. The average age was 63 (range: 43-84) years. The wound reduction rate was significantly higher in Group B than in Group A on postoperative days (PODs) 7 (66.1 vs. 48.4%, p = 0.049) and 10 (78.6 vs. 58.2%, p = 0.011), whereas no significant difference was observed on POD 14. Compared with Group A, Group C (POD 7: 65.9%, POD 10: 69.2%) showed an increase in the wound reduction rate on POD 7, although the difference was not significant (p = 0.075). SSIs were observed in Groups B (n = 2) and C (n = 2) (20%) but not in Group A (0%). Conclusions The most effective duration of NPWT use for ileostomy closure with PSS in terms of the maximum wound reduction rate was from PODs 3 to 10. However, NPWT did not shorten the wound healing duration. NPWT may reduce the wound size but should be used with precautions for SSIs. The small sample size (30 cases), the use of only one type of NPWT system, and the fact that wound assessment was subjective and not blinded were the limitations of this study. Further studies are needed to confirm our findings. Trial registration: UMIN Clinical Trials Registry; UMIN000032174 (10/04/2018).
C1 [Kojima, Koichiro; Masaki, Tadahiko; Sunami, Eiji] Kyorin Univ, Dept Surg, Sch Med, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan.
   [Goto, Mayu; Nagashima, Yasuo; Funahashi, Kimihiko] Toho Univ, Dept Gen & Gastroenterol Surg, Omori Med Ctr, Tokyo, Japan.
   [Saito, Yoko] Toho Univ, Dept Nursing, WOCN, Omori Med Ctr, Tokyo, Japan.
   [Kawai, Masaya; Sakamoto, Kazuhiro] Juntendo Univ, Dept Coloproctol Surg, Sch Med, Tokyo, Japan.
   [Takebe, Shihori] Juntendo Univ, Sch Med, Dept Nursing, WOCN, Tokyo, Japan.
   [Egawa, Akiko] Jikei Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Tanba, Mitsuko] Kyorin Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Ishikawa, Kazue] Teikyo Univ, Dept Nursing, WOCN, Sch Med, Tokyo, Japan.
   [Matsuoka, Hiroyoshi] Kyorin Univ, Dept Paramed, Fac Hlth Sci, Tokyo, Japan.
   [Ohura, Norihiko] Kyorin Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Tokyo, Japan.
   [Teruya, Koji] Kyorin Univ, Dept Hlth & Welf, Fac Hlth Sci, Tokyo, Japan.
   [Eto, Ken] Jikei Univ, Sch Med, Dept Surg, Tokyo, Japan.
   [Nozawa, Keijiro] Teikyo Univ, Dept Surg, Sch Med, Tokyo, Japan.
C3 Kyorin University; Toho University; Toho University; Juntendo
   University; Juntendo University; Jikei University; Kyorin University;
   Teikyo University; Kyorin University; Kyorin University; Kyorin
   University; Jikei University; Teikyo University
RP Kojima, K (通讯作者)，Kyorin Univ, Dept Surg, Sch Med, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan.
EM k-kojikoji@ks.kyorin-u.ac.jp
RI Tadahiko, Masaki/AAE-6843-2019
OI Eto, Ken/0000-0002-3628-4493
CR Amamo K, 2019, SURG TODAY, V49, P231, DOI 10.1007/s00595-018-1729-5
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NR 19
TC 12
Z9 16
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 28
PY 2021
VL 21
IS 1
AR 442
DI 10.1186/s12893-021-01446-2
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XW2AQ
UT WOS:000735429100002
PM 34963451
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Benrashid, E
   Youngwirth, LM
   Guest, K
   Cox, MW
   Shortell, CK
   Dillavou, ED
AF Benrashid, Ehsan
   Youngwirth, Linda M.
   Guest, Kimberly
   Cox, Mitchell W.
   Shortell, Cynthia K.
   Dillavou, Ellen D.
TI Negative pressure wound therapy reduces surgical site infections
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 32nd Annual Meeting of the Eastern-Vascular-Society (EVS)
CY SEP 06-08, 2018
CL Washington, DC
SP Eastern Vasc Soc
DE Surgical site infection; Wound closure; Perioperative care
ID VASCULAR-SURGERY; RISK-FACTORS; ARTERIAL RECONSTRUCTION; COLORECTAL
   SURGERY; PREDICTORS; PREVENTION; OUTCOMES; REVASCULARIZATION;
   COMPLICATIONS; REDUCTION
AB Objective: Surgical site infection (SSI) with lower extremity incisions represents a modifiable source of major morbidity. Our institutional bundled care protocol to decrease SSI includes optimization of perioperative risk factors, dedicated wound closure tray, and voluntary use of a closed surface negative pressure wound therapy (cNPWT) device applied over closed incisions in the operating room. This study examined the individual effect of cNPWT on SSI reduction and other perioperative outcomes.
   Methods: All patients with lower extremity or infrainguinal incisions between January 2016 and December 2017 were prospectively identified and tracked for infectious complications. All patients were treated with the same perioperative care bundle to reduce SSI. cNPWT was applied over closed incisions at the discretion of the surgeon. The 90-day outcomes regarding SSI, return to operating room, death, and readmission were tracked. Univariate and multivariate analysis using binary logistic regression for factors associated with SSI was performed for patients with and without cNPWT devices, with P < .05 determined to be significant.
   Results: There were 504 patients included, 225 with cNPWT and 279 with standard dressings. Between the groups, there were no major differences in mean age, mean body mass index, perioperative transfusions, use of prosthetic, reoperative field, dialysis status, and presence of diabetes. There were significantly more women (39.6% vs 27.2% female; P < .01) and active smokers (47.1% vs 30.2%; P < .01) in the cNPWT group along with increased mean operative times (238.3 vs 189.0 minutes; P < .01). Univariate analysis revealed significantly fewer SSIs with cNPWT (9.8% vs 19.0% in standard dressings; P < .01) along with decreased perioperative mortality (5.8% vs 11.2%; P = .04). There were no differences in return to operating room (27.6% cNPWT vs 27.7% standard; P = .97) or readmissions (29.8% cNPWT vs 26.5%; P = .43), but more returns to the operating room were for wound-related problems in the standard dressings group (48.3% vs 26.2%; P < .01). Binary logistic regression using an SSI end point demonstrated that female sex increases SSI (odds ratio, 2.43; confidence interval, 1.37-4.30; P < .01), whereas cNPWT reduces SSI (odds ratio, 0.32; confidence interval, 0.17-0.63; P < .01).
   Conclusions: The use of negative pressure wound therapy devices decreases the incidence of infrainguinal wound infections. This occurs as an independent factor as part of a patient care bundle targeting modifiable variables in perioperative care.
C1 [Benrashid, Ehsan; Youngwirth, Linda M.; Guest, Kimberly; Cox, Mitchell W.; Shortell, Cynthia K.; Dillavou, Ellen D.] Duke Univ, Med Ctr, Dept Surg, Div Vasc Surg, Durham, NC 27710 USA.
C3 Duke University
RP Dillavou, ED (通讯作者)，Div Vasc Surg, Vasc Surg, 407 Crutchfield St, Durham, NC 27704 USA.
EM ellen.dillavou@duke.edu
RI Cox, Mitchell/AHD-6296-2022
OI Benrashid, Ehsan/0000-0003-4216-6095
FU Acelity Corp, San Antonio, TX, USA
FX This work was funded in part by Acelity Corp, San Antonio, TX, USA.
   Acelity had no involvement in the study design; collection, analysis,
   and interpretation of data; manuscript writing; or decision to submit
   the manuscript for publication.
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NR 32
TC 21
Z9 22
U1 1
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAR
PY 2020
VL 71
IS 3
BP 896
EP 904
DI 10.1016/j.jvs.2019.05.066
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA KN4ZJ
UT WOS:000514846800039
PM 31471232
DA 2026-07-24
ER

PT J
AU Manasrah, A
   Ayyad, A
   Abu Suilik, H
   Zibara, Z
   Alalawneh, A
   Bataineh, Z
   Rjoub, S
   Al Akash, MA
   Tanashat, M
AF Manasrah, AlMothana
   Ayyad, Alaa
   Abu Suilik, Husam
   Zibara, Zahraa
   Alalawneh, Alshayma
   Bataineh, Zaid
   Rjoub, Samah
   Al Akash, Minnat Allah
   Tanashat, Mohammad
TI Negative Pressure Wound Therapy Versus Standard Dressings for Preventing
   Surgical Site Infections Following Abdominal Surgery: A Systematic
   Review and Meta-Analysis of Randomized Controlled Trials
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE abdominal surgery; meta-analysis; negative pressure wound therapy;
   randomized controlled trials; surgical site infection; wound management
ID IMPACT; COSTS
AB Background Surgical site infections (SSIs) are among the most frequent postoperative complications, contributing significantly to patient morbidity, prolonged hospital stays, and increased healthcare costs. Prophylactic negative pressure wound therapy (ciNPWT) has emerged as a potential strategy to reduce SSIs, particularly in abdominal surgery, but its effectiveness remains debated.Objective To evaluate the effectiveness of ciNPWT in reducing SSI rates and other surgical outcomes following abdominal surgery by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).Methods We performed a comprehensive meta-analysis of RCTs assessing the use of ciNPWT versus standard wound care in abdominal surgeries including mixed wound contamination classes (e.g., clean-contaminated to contaminated/dirty procedures). The protocol was registered with PROSPERO (https://www.crd.york.ac.uk/prospero/Registration ID: CRD420251005562). Primary outcomes included SSI incidence, while secondary outcomes comprised mortality, hematoma, hospital readmission, reoperation, length of stay, and other incisional complications. Sensitivity analyses and trial sequential analyses were conducted to assess the robustness of findings.Results A total of 11 studies involving 2519 patients were included. NPWT significantly reduced the risk of surgical site infection compared to standard dressings (RR = 0.61 (95% CI: 0.44-0.86); p = 0.004). Substantial heterogeneity was present (I2 = 66%; p for heterogeneity = 0.001), which was not resolved by sensitivity analyses. No significant differences were observed in mortality (RR = 0.90 (95% CI: 0.48-1.69); p = 0.74), hematoma (RR = 0.75 (95% CI: 0.37-1.52); p = 0.42), or bleeding (RR = 0.54 (95% CI: 0.15-2.02); p = 0.36). NPWT showed no significant effects on readmission (RR = 0.65 (95% CI: 0.37-1.16); p = 0.15), reoperation (RR = 1.27 (95% CI: 0.45-3.58); p = 0.66), or length of hospital stay (MD = -0.32 (95% CI: -0.81 to 0.18); p = 0.21). Trial sequential analysis (TSA) confirmed the robustness of the primary outcome, and sensitivity analyses supported the consistency of results.Conclusions ciNPWT appears effective in reducing SSIs in abdominal surgery, yet its broader clinical value remains uncertain due to inconsistent benefits across secondary outcomes and unresolved heterogeneity. Future studies should focus on standardizing ciNPWT protocols, identifying high-risk subgroups, and evaluating cost-effectiveness, particularly in resource-limited settings.
C1 [Manasrah, AlMothana] Wilson Med Ctr, Internal Med Dept, UHS, Johnson City, NY USA.
   [Ayyad, Alaa] Al Quds Univ, Fac Med, Jerusalem, Palestine.
   [Abu Suilik, Husam] Hashemite Univ, Fac Med, Zarqa, Jordan.
   [Zibara, Zahraa] Lebanese Amer Univ, Gilbert & Rose Marie Chagoury Sch Med, Byblos, Lebanon.
   [Alalawneh, Alshayma; Al Akash, Minnat Allah; Tanashat, Mohammad] Yarmouk Univ, Fac Med, Irbid, Jordan.
   [Bataineh, Zaid] Jordan Univ Sci & Technol, Fac Med, Irbid, Jordan.
   [Rjoub, Samah] Yarmouk Univ, Fac Med, Dept Basic Pathol Sci, Irbid, Jordan.
C3 Al-Quds University; Hashemite University; Lebanese American University;
   Yarmouk University; Jordan University of Science & Technology; Yarmouk
   University
RP Zibara, Z (通讯作者)，Lebanese Amer Univ, Gilbert & Rose Marie Chagoury Sch Med, Byblos, Lebanon.
EM zahraa.zibara@lau.edu
RI ayyad, Alaa/LKO-3284-2024
OI Rjoub, Samah/0009-0000-0848-647X; Manasrah,
   AlMothana/0009-0001-6266-4991
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUL
PY 2026
VL 50
IS 7
BP 1862
EP 1874
DI 10.1002/wjs.70404
EA MAY 2026
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KX6GD
UT WOS:001763828900001
PM 42128818
DA 2026-07-24
ER

PT J
AU Stanciu, CT
   Velimirovici, MD
   Vermesan, D
   Pilut, CN
   Stana, L
   Bratosin, F
   Pop, DL
   Hogea, B
AF Stanciu, Cristina-Teodora
   Velimirovici, Milan Daniel
   Vermesan, Dinu
   Pilut, Ciprian Nicolae
   Stana, Loredana
   Bratosin, Felix
   Pop, Daniel Laurentiu
   Hogea, Bogdan
TI Comparative Recovery After Acute Lower-Limb Wounds Treated with
   Negative-Pressure Wound Therapy and Three Gradations of Manual
   Rehabilitation
SO HEALTHCARE
LA English
DT Article
DE negative-pressure wound therapy; physical therapy modalities;
   proprioceptive neuromuscular facilitation; lower extremity injuries;
   wound healing
ID SF-36
AB Background and Objectives: Negative-pressure wound therapy (NPWT) expedites tissue repair, yet functional recovery depends on adjunct rehabilitation. Evidence from high-resource settings is difficult to translate to Romanian county hospitals, where advanced devices are scarce. The objective of this study is to determine whether two tiers of low-technology, therapist-delivered exercise improve mobility, oedema resolution, pain and quality-of-life (QoL) beyond NPWT alone in adults with acute lower-limb wounds. Methods: A single-centre, prospective observational study (January 2021-June 2024) enrolled 92 patients and randomised them unevenly into: Group A, NPWT only (n = 39); Group B, NPWT + routine physiotherapy (n = 33); Group C, NPWT + enhanced manual programme (n = 20). All received -125 mmHg continuous suction; rehabilitation started 48 h post-operation. Primary outcomes were ankle dorsiflexion and knee flexion at 12 weeks. Secondary outcomes included calf circumference, ultrasound oedema depth, Manual Muscle Testing (MMT), pain (VAS), analgesic use and SF-36 domains through 24 weeks. Results: Baseline characteristics were similar (p > 0.40). At 12 weeks dorsiflexion reached 20.1 +/- 1.8 degrees in Group C, surpassing Group B (18.4 +/- 2.1 degrees; p = 0.004) and Group A (16.0 +/- 2.3 degrees; p < 0.001). Knee flexion followed the same gradient (140.8 +/- 3.2 degrees, 137.6 +/- 3.4 degrees, 133.4 +/- 3.8 degrees respectively). Oedema depth fell fastest in Group C (0.4 +/- 0.2 mm by day 42) versus B (0.6 +/- 0.2 mm) and A (0.8 +/- 0.3 mm). Week-12 MMT grade >= 4.5 was attained by 95% of Group C, 85% of B and 72% of A (chi(2) = 10.9, p = 0.004). VAS pain fell more steeply with each rehabilitation layer, paralleled by a stepwise decline in daily tramadol. All SF-36 domains were highest in Group C at 24 weeks (Physical Function 88.7 +/- 4.8 vs. 85.1 +/- 5.4 vs. 78.2 +/- 5.9; p < 0.001). Mobility correlated positively with QoL (r = 0.66) and inversely with pain and oedema. Conclusions: In a resource-constrained Romanian setting, adding structured manual physiotherapy to NPWT produced meaningful functional and patient-centred gains, while an "enhanced" programme incorporating daily PNF and elastic-band strengthening delivered the largest observed benefit. These findings justify prioritising therapist-led interventions even where sophisticated equipment is unavailable.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm, Doctoral Sch, Timisoara 300041, Romania.
   [Velimirovici, Milan Daniel] Victor Babes Univ Med & Pharm, Fac Nursing, Dept Nursing 1, Timisoara 300041, Romania.
   [Vermesan, Dinu; Pop, Daniel Laurentiu; Hogea, Bogdan] Victor Babes Univ Med & Pharm, Dept Orthoped 16, Discipline Orthoped & Traumatol 1, Timisoara 300041, Romania.
   [Pilut, Ciprian Nicolae] Victor Babes Univ Med & Pharm, Dept Dermatol, Timisoara 300041, Romania.
   [Stana, Loredana] Victor Babes Univ Med & Pharm, Dept Discipline Anat & Embryol 1, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Bratosin, Felix] Victor Babes Univ Med & Pharm, Dept Infect Dis, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara
RP Pilut, CN (通讯作者)，Victor Babes Univ Med & Pharm, Dept Dermatol, Timisoara 300041, Romania.; Stana, L (通讯作者)，Victor Babes Univ Med & Pharm, Dept Discipline Anat & Embryol 1, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; milan.velimirovici@umft.ro; dinu@vermesan.ro;
   pilut.nicolae@umft.ro; loredana.stana@umft.ro; felix.bratosin@umft.ro;
   daniellaurentiupop@yahoo.com; hogea.bogdan@umft.ro
RI Nicolae Ciprian, Pilut/LWI-2658-2024; Bratosin, Felix/HDN-8724-2022
OI Nicolae Ciprian, Pilut/0009-0006-9681-8289; Bratosin,
   Felix/0000-0003-4711-4315; Hogea, Bogdan/0000-0003-4924-7832
FU Victor Babes University of Medicine and Pharmacy; Victor Babes
   University of Medicine and Pharmacy for paying the APC
FX We acknowledge the Victor Babes University of Medicine and Pharmacy for
   paying the APC.
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NR 35
TC 0
Z9 0
U1 1
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JUN 23
PY 2025
VL 13
IS 13
AR 1496
DI 10.3390/healthcare13131496
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 4UU6W
UT WOS:001527181500001
PM 40648523
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Beitz, JM
   van Rijswijk, L
AF Beitz, Janice M.
   van Rijswijk, Lia
TI Content Validation of Algorithms to Guide Negative Pressure Wound
   Therapy in Adults with Acute or Chronic Wounds: A Cross-sectional Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE wounds; algorithms; negative pressure wound therapy; validation studies;
   patient safety
ID CARE ALGORITHMS; MANAGEMENT; VACUUM
AB Despite extensive use of negative pressure wound therapy (NPWT) and reported patient safety concerns, evidence-based algorithms to guide its safe and appropriate use in various wounds have only recently been developed. Preliminary content validity was established using literature review and expert-based face validity with a small sample of experts (N = 12). To examine the content validity of this set of three NPWT algorithms and to enhance understanding about previously identified wound terminology issues, a cross-sectional, mixed-methods, quantitative study was conducted among wound experts. The paper/pencil survey instrument consisted of the algorithms, a demographic questionnaire, and request to provide definitions of five commonly used terms: acute wound, chronic wound, and primary, secondary, and tertiary intention healing. A Likert scale (range 1 to 4) was included to rate the relevance of each of the 34 unique steps/statements/decision points contained in the algorithms, and space was provided to comment on each component. Convenience-sampling methods were used in three different settings: an international professional wound care meeting; a regional wound, ostomy, continence (WOC) nurses meeting; and an urban university with a suburban satellite campus. Of the 190 wound care experts invited to participate, 114 accepted. Participants' average age was 48 (range 23 to 68) years, and most were registered nurses (72%) practicing in the United States (94%).
   The content validity of the NPWT components was strong, with an overall mean rating of 3.76 (SD = 0.56, range 3.49 to 3.92; very relevant/appropriate, relevant/appropriate). The overall content validity index for the 5,696 responses received was 0.96 (range 0.88 to 1.0). Qualitative themes included comments about wound terminology and definitions, the presentation of the central algorithm, reading level, helpfulness/ease of use, the use of color, and information placement in the algorithm document.
   Some consensus on wound definitions was observed, but results also confirmed that important disparities in mutual understanding of what constitutes acute versus chronic wounding remain. Commonly used surgical closure definitions of primary, secondary, tertiary intention also were not clearly or correctly understood by a substantial number of participants. These NPWT algorithms are the first evidence-based, content-validated algorithms developed for a variety of acute and chronic wounds in adult patients. Future research is needed to test whether they facilitate safe patient care in clinical practice
C1 [Beitz, Janice M.] Rutgers State Univ, Sch Nursing Camden, Camden, NJ 08102 USA.
   [van Rijswijk, Lia] Holy Family Univ, Sch Nursing & Allied Hlth Profess, Philadelphia, PA USA.
   [van Rijswijk, Lia] Ostomy Wound Management, Malvern, PA USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Camden
RP Beitz, JM (通讯作者)，Rutgers State Univ, Sch Nursing Camden, 407 Armitage Hall,311 North 5th St, Camden, NJ 08102 USA.
EM Janice.beitz@camden.rutgers.edu
RI vanRijswijk, Lia/LZF-6639-2025
FU ConvaTec (Skillman, NJ)
FX This study was supported by a research grant from ConvaTec (Skillman,
   NJ). The study was conducted, the data analyzed, and the manuscript
   written by the authors who are responsible for the content, of this
   publication. The authors do not have a financial interest in any of the
   products discussed in this publication.
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NR 51
TC 5
Z9 8
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2012
VL 58
IS 9
BP 32
EP 40
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA V30TQ
UT WOS:000208838700006
PM 22933699
DA 2026-07-24
ER

PT J
AU Asher, SA
   White, HN
   Illing, EA
   Carroll, WR
   Magnuson, JS
   Rosenthal, EL
AF Asher, Scott A.
   White, Hilliary N.
   Illing, Elisa A.
   Carroll, William R.
   Magnuson, J. Scott
   Rosenthal, Eben L.
TI Intraluminal Negative Pressure Wound Therapy for Optimizing Pharyngeal
   Reconstruction
SO JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
LA English
DT Article
ID SALVAGE TOTAL LARYNGECTOMY; ORGAN PRESERVATION THERAPY; ASSISTED CLOSURE
   DEVICE; PHARYNGOCUTANEOUS-FISTULA; ANASTOMOTIC LEAKAGE; VACUUM THERAPY;
   SOFT-TISSUE; NECK WOUNDS; MANAGEMENT; COMPLICATIONS
AB IMPORTANCE Pharyngocutaneous fistula formation after pharyngeal reconstruction is one of the most common and challenging problems to manage. Despite many advances in management, the published success rates indicate a role for any adjuvant therapy that could potentially decrease this complication.
   OBJECTIVE To describe the use of intraluminal negative pressure dressings (NPDs) in pharyngeal reconstruction.
   DESIGN, SETTING, AND PARTICIPANTS Retrospective case series at a tertiary care academic hospital. Twelve laryngectomy patients underwent pharyngeal reconstruction augmented by placement of an intrapharyngeal NPD in combination with the introduction of vascularized tissue from August 2011 to May 2012. All patients had potential risk factors for compromised wound healing defined as previous radiation therapy, hypothyroidism, diabetes mellitus, compromised nutrition, or established pharyngocutaneous fistula.
   INTERVENTIONS An NPD was placed in an intraluminal position spanning the length of the pharyngeal defect as part of the reconstructive procedure. The negative pressure sponge was attached to a standard nasogastric tube to which negative pressure was applied. External closure of the pharynx was then achieved with regional or free tissue transfer.
   MAIN OUTCOMES AND MEASURES Pharyngeal closure rates, timing until return to oral diet, identification of wound healing risk factors, and adverse events related to use of the device.
   RESULTS Eleven of 12 patients (92%) achieved pharyngeal closure with reconstruction using negative pressure wound therapy. All patients had at least 1 potential risk factor for compromised wound healing, with 11 of 12 (92%) having 2 or more. Seven patients had an established pharyngocutaneous fistula, and 5 patients underwent primary reconstruction after laryngopharyngectomy. In 6 of these 7 patients undergoing fistula repair, pharyngeal closure was achieved, and they resumed an oral diet at 1 week postoperatively. The other had successful leak repair initially, but 1 week later developed a separate area of wound breakdown and a second fistula. All 5 patients in whom an intraluminal NPD was placed at the time of initial vacularized tissue reconstruction were able to resume an oral diet by 3 weeks postoperatively, with 3 of them eating by mouth at 1 week postoperatively. No serious adverse events could be attributed to the use of intraluminal NPDs.
   CONCLUSIONS AND RELEVANCE Intraluminal negative pressure wound therapy is feasible and safe. Future research should be conducted to determine its potential in optimizing pharyngeal reconstruction in high-risk patients.
C1 [Asher, Scott A.; White, Hilliary N.; Illing, Elisa A.; Carroll, William R.; Magnuson, J. Scott; Rosenthal, Eben L.] Univ Alabama Birmingham, Div Otolaryngol Head & Neck Surg, Dept Surg, Sch Med, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Rosenthal, EL (通讯作者)，Div Otolaryngol Head & Neck Surg, BDB Ste 563,1808 7th Ave South, Birmingham, AL 35233 USA.
EM oto@uab.edu
RI Rosenthal, Eben/KLC-3513-2024; Magnuson, Jason/ABX-9283-2022
OI Rosenthal, Eben/0000-0003-0294-5203; 
CR Andrades P, 2008, LARYNGOSCOPE, V118, P1157, DOI 10.1097/MLG.0b013e31816f695a
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   Dhir K, 2009, LARYNGOSCOPE, V119, P54, DOI 10.1002/lary.20000
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NR 42
TC 23
Z9 30
U1 0
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6181
EI 2168-619X
J9 JAMA OTOLARYNGOL
JI JAMA Otolaryngol-Head Neck Surg.
PD FEB
PY 2014
VL 140
IS 2
BP 143
EP 149
DI 10.1001/jamaoto.2013.6143
PG 7
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA AC8FB
UT WOS:000332767800010
PM 24370595
DA 2026-07-24
ER

PT J
AU Petkar, KS
   Dhanraj, P
   Kingsly, PM
   Sreekar, H
   Lakshmanarao, A
   Lamba, S
   Shetty, R
   Zachariah, JR
AF Petkar, Kiran S.
   Dhanraj, Prema
   Kingsly, Paul M.
   Sreekar, H.
   Lakshmanarao, Aravind
   Lamba, Shashank
   Shetty, Rahul
   Zachariah, Jewel Raj
TI A prospective randomized controlled trial comparing negative pressure
   dressing and conventional dressing methods on split-thickness skin
   grafts in burned patients
SO BURNS
LA English
DT Article
DE Negative pressure dressings; Vacuum assisted closure; Skin graft
ID VACUUM-ASSISTED CLOSURE; DONOR SITE; BOLSTER; WOUNDS
AB Introduction: Split-thickness skin grafting (SSG) is a technique used extensively in the care of burn patients and is fraught with suboptimal graft take when there is a less-than-ideal graft bed and/or grafting conditions. The technique of Negative Pressure Dressing (NPD), initially used for better wound healing has been tried on skin-grafts and has shown to increase the graft take rates. However, comparative studies between the conventional dressing and vacuum assisted closure on skin grafts in burn patients are unavailable. The present study was undertaken to find out if NPD improves graft take as compared to conventional dressing in burns patients.
   Materials and methods: Consecutive burn patients undergoing split-skin grafting were randomized to receive either a conventional dressing consisting of Vaseline gauze and cotton pads or to have a NPD of 80 mm Hg for four days over the freshly laid SSG. The results in terms of amount of graft take, duration of dressings for the grafted area and the cost of treatment of wound were compared between the two groups.
   Results: A total of 40 split-skin grafts were put on 30 patients. The grafted wounds included acute and chronic burns wounds and surgically created raw areas during burn reconstruction. Twenty-one of them received NPD and 19 served as controls. Patient profiles and average size of the grafts were comparable between the two groups. The vacuum closure assembly was well tolerated by all patients. Final graft take at nine days in the study group ranged from 90 to 100 per cent with an average of 96.7 per cent (SD: 3.55). The control group showed a graft take ranging between 70 and 100 percent with an average graft take of 87.5 percent (SD: 8.73). Mean duration of continued dressings on the grafted area was 8 days in cases (SD: 1.48) and 11 days in controls (SD: 2.2) after surgery. Each of these differences was found to be statistically significant (p < .0.001).
   Conclusion: Negative pressure dressing improves graft take in burns patients and can particularly be considered when wound bed and grafting conditions seem less-than-ideal. The negative pressure can also be effectively assembled using locally available materials thus significantly reducing the cost of treatment. (C) 2011 Elsevier Ltd and ISBI. All rights reserved.
C1 [Petkar, Kiran S.; Dhanraj, Prema; Kingsly, Paul M.; Sreekar, H.; Lakshmanarao, Aravind; Lamba, Shashank; Shetty, Rahul; Zachariah, Jewel Raj] Christian Med Coll & Hosp, Dept Plast Surg, Vellore 632004, Tamil Nadu, India.
C3 Christian Medical College & Hospital (CMCH) Vellore
RP Petkar, KS (通讯作者)，Christian Med Coll & Hosp, Dept Plast Surg, Vellore 632004, Tamil Nadu, India.
EM drkiranpetkar2009@gmail.com
RI ; Doss, Kingsly/AAM-9639-2020
OI Petkar, Kiran/0000-0002-3129-4529; Sreekar,
   Harinatha/0000-0001-5364-1475
CR Andrews BT, 2006, LARYNGOSCOPE, V116, P1918, DOI 10.1097/01.mlg.0000235935.07261.98
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NR 11
TC 96
Z9 112
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD SEP
PY 2011
VL 37
IS 6
BP 925
EP 929
DI 10.1016/j.burns.2011.05.013
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 815GA
UT WOS:000294512900002
PM 21723044
DA 2026-07-24
ER

PT J
AU Hatch, QM
   Osterhout, LM
   Ashraf, A
   Podbielski, J
   Kozar, RA
   Wade, CE
   Holcomb, JB
   Cotton, BA
AF Hatch, Quinton M.
   Osterhout, Lisa M.
   Ashraf, Asma
   Podbielski, Jeanette
   Kozar, Rosemary A.
   Wade, Charles E.
   Holcomb, John B.
   Cotton, Bryan A.
TI Current Use of Damage-Control Laparotomy, Closure Rates, and Predictors
   of Early Fascial Closure at the First Take-Back
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE Trauma; Laparotomy; Damage control; Temporary closure
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN;
   TRAUMA PATIENTS; WOUND CLOSURE; DEFINITIVE CLOSURE; EARLY COAGULOPATHY;
   TEMPORARY CLOSURE; VENTRAL HERNIA; MANAGEMENT
AB Background: Damage-control laparotomy (DCL) is a lifesaving technique but carries significant morbidity. If DCL is over used and the factors that predict early fascial closure have not been fully evaluated. The purpose of the current study was to determine (1) the current rate of DCL, (2) the percentage of DCLs that are closed at first take-back, and (3) possible physiologic and resuscitative parameters predicting early fascial closure.
   Methods: A retrospective review of all trauma laparotomies from a Level I trauma center between January 2004 and December 2008 was performed. Patients were excluded if they died before first take-back. Univariate and multivariate analyses were performed.
   Results: Nine hundred thirty patients were eligible, 278 (30%) underwent DCL, 36 excluded for death before first take-back. Of the remaining 242 DCL patients, 83 (34%) were closed at first take-back and 159 (66%) were not closed at first take-back. These two groups were similar in injury severity, demographics, and prehospital and emergency department fluids and vitals. Median emergency department international normalized ratio (INR; 1.13 vs. 1.29, p = 0.010), post-op INR (1.4 vs. 1.5, p = 0.028), 24-hour fluids (11.9 L vs. 15.5 L, p = 0.006), peak post-op intra-abdominal pressure (IAP; 15 vs. 18, p < 0.001), and mortality (1.2% vs. 8.2%, p = 0.027) were different between groups. Multivariate analysis noted vacuum-assisted closure at initial laparotomy (Odds ratio, 3.1; 95% confidence interval [CI], 1.42-6.63; p = 0.004) was an independent predictor of closure at first take-back. However, post-op INR (Odds ratio, 0.18; 95% CI, 0.03-0.97; p = 0.04) and post-op peak IAP (Odds ratio, 0.85; 95% CI, 0.76-0.95; p = 0.005) predicted failure to close fascia at first take-back.
   Conclusion: In similarly injured DCL patients, increased post-op INR and IAP predicted inability to achieve primary fascial closure on first take-back, while use of the vacuum-assisted closure was associated with increased likelihood of early fascial closure. At a busy academic Level I trauma center, the current rate of DCL among those undergoing emergent laparotomy is 30%. Whether this represents optimal use or overutilization of this technique still needs to be determined.
C1 Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA.
   Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston
RP Cotton, BA (通讯作者)，UTHSCH CeTIR, 6410 Fannin St,1100-20 UPB, Houston, TX 77030 USA.
EM bryan.a.cotton@uth.tmc.edu
RI ; Cotton, Bryan/A-7107-2009; ashraf, Asma/LMN-0743-2024
OI holcomb, john/0000-0001-8312-9157; ashraf, Asma/0000-0001-7026-670X
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NR 59
TC 54
Z9 58
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUN
PY 2011
VL 70
IS 6
BP 1429
EP 1436
DI 10.1097/TA.0b013e31821b245a
PG 8
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 775QR
UT WOS:000291478500029
PM 21817981
DA 2026-07-24
ER

PT J
AU Berrevoet, F
   Lampaert, S
   Singh, K
   Jakipbayeva, K
   van Cleven, S
   Vanlander, A
AF Berrevoet, Frederik
   Lampaert, Silvio
   Singh, Kashika
   Jakipbayeva, Kamilya
   van Cleven, Stijn
   Vanlander, Aude
TI Early Initiation of a Standardized Open Abdomen Treatment With Vacuum
   Assisted Mesh-Mediated Fascial Traction Achieves Best Results
SO FRONTIERS IN SURGERY
LA English
DT Article
DE open abdomen; dynamic closure; negative pressure therapy; fascial
   closure; abdominal compartment syndrome; mesh mediated fascial traction
ID PRESSURE WOUND THERAPY; SEPTIC PATIENTS; DELAYED CLOSURE; MANAGEMENT;
   CLASSIFICATION
AB Background: The open abdomen (OA) is an important approach for managing intra-abdominal catastrophes and continues to be the standard of care. Complete fascial closure is an essential treatment objective and can be achieved by the use of different dynamic closure techniques. Both surgical technique and-decision making are essential for optimal patient outcome in terms of fascial closure. The aim of this study was to analyse patients' outcome after the use of mesh-mediated fascial traction (MMFT) associated with negative pressure wound therapy (NPWT) and identify important factors that negatively influenced final fascial closure.
   Methods: A single center ambispective analysis was performed including all patients treated for an open abdomen in a tertiary referral center from 3/2011 till 2/2020. All patients with a minimum survival >24 h after initiation of treatment were analyzed. The data concerning patient management was collected and entered into the Open Abdomen Route of the European Hernia Society (EHS). Patient basic characteristics considering OA indication, primary fascial closure, as well as important features in surgical technique including time after index procedure to start mesh mediated fascial traction, surgical closure techniques and patients' long-term outcomes were analyzed.
   Results: Data were obtained from 152 patients who underwent open abdomen therapy (OAT) in a single center study. Indications for OAT as per-protocol analysis were sepsis (33.3%), abdominal compartment syndrome (31.6%), followed by peritonitis (24.2%), abdominal trauma (8.3%) and burst abdomen (2.4%). Overall fascial closure rate was 80% as in the per-protocol analysis. When patients that started OA management with MMFT and NPWT from the initial surgery a significantly better fascial closure rate was achieved compared to patients that started 3 or more days later (p < 0.001). An incisional hernia developed in 35.8% of patients alive with a median follow-up of 49 months (range 6-96 months).
   Conclusion: Our main findings emphasize the importance of a standardized treatment plan, initiated early on during management of the OA. The use of vacuum assisted closure in combination with MMFT showed high rates of fascial closure. Absence of initial intraperitoneal NPWT as well as delayed start of MMFT were risk factors for non-fascial closure. Initiation of OA with VACM should not be unnecessary delayed.
C1 [Berrevoet, Frederik; Lampaert, Silvio; Singh, Kashika; Jakipbayeva, Kamilya; van Cleven, Stijn; Vanlander, Aude] Ghent Univ Hosp, Dept Gen & Hepatopancreaticobiliary Surg & Liver, Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Berrevoet, F (通讯作者)，Ghent Univ Hosp, Dept Gen & Hepatopancreaticobiliary Surg & Liver, Ghent, Belgium.
EM frederik.berrevoet@ugent.be
RI Vanlander, Aude/AAP-3342-2021; Lampaert, Silvio/HMP-2845-2023;
   Berrevoet, Frederik/A-6117-2008
CR Acosta S, 2017, ANAESTH INTENSIVE TH, V49, P139, DOI 10.5603/AIT.a2017.0023
   Berrevoet F, 2018, FRONT SURG, V5, DOI 10.3389/fsurg.2018.00011
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NR 34
TC 10
Z9 16
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD FEB 9
PY 2021
VL 7
AR 606539
DI 10.3389/fsurg.2020.606539
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QK7JB
UT WOS:000620557300001
PM 33634162
OA Green Accepted, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Rasilainen, S
   Mentula, P
   Salminen, P
   Koivukangas, V
   Hyöty, M
   Mäntymäki, LM
   Pinta, T
   Haikonen, J
   Rintala, J
   Rantanen, T
   Strander, T
   Leppäniemi, A
AF Rasilainen, Suvi
   Mentula, Panu
   Salminen, Paulina
   Koivukangas, Vesa
   Hyoty, Marja
   Mantymaki, Leena-Mari
   Pinta, Tarja
   Haikonen, Jyrki
   Rintala, Jukka
   Rantanen, Tuomo
   Strander, Tapani
   Leppaniemi, Ari
TI Superior primary fascial closure rate and lower mortality after open
   abdomen using negative pressure wound therapy with continuous fascial
   traction
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Open abdomen; temporary abdominal closure; enteroatmospheric fistula;
   delayed primary fascial closure
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION; MANAGEMENT;
   VACUUM; CLASSIFICATION; FISTULA
AB BACKGROUND
   Open abdomen (OA) is a useful option for treatment strategy in many acute abdominal catastrophes. A number of temporary abdominal closure (TAC) methods are used with limited number of comparative studies. The present study was done to examine risk factors for failed delayed primary fascial closure (DPFC) and risk factors for mortality in patients treated with OA. METHODS
   This study was a multicenter retrospective analysis of the hospital records of all consecutive patients treated with OA during the years 2009 to 2016 at five tertiary referral hospitals and three secondary referral centers in Finland. RESULTS
   Six hundred seventy-six patients treated with OA were included in the study. Vacuum-assisted closure with continuous mesh-mediated fascial traction (VACM) was the most popular TAC method used (N = 398, 59%) followed by VAC (N = 128, 19%), Bogota bag (N = 128, 19%), and self-designed methods (N = 22, 3%). In multivariate analysis, enteroatmospheric fistula and the number of needed TAC changes increased the risk for failed DPFC (odds ratio [OR], 8.9; 95% confidence interval [CI], 6.2-12.8; p < 0.001 and OR, 1.1; 95% CI, 1.0-1.3; p < 0.001, respectively). Instead, VACM and ruptured abdominal aortic aneurysm as cause for OA both decreased the risk for failed DPFC (OR, 0.1; 95% CI, 0.0-0.3; p < 0.001 and OR, 0.2; 95% CI, 0.1-0.7; p = 0.012). The overall mortality rate was 30%. In multivariate analysis for mortality, multiorgan dysfunction (OR, 2.4; 95% CI, 1.6-3.6; p < 0.001), and increasing age (OR, 4.5; 95% CI, 2.0-9.7; p < 0.001) predicted increased mortality. Institutional large annual patient volume (OR, 0.4; 95% CI, 0.3-0.6; p < 0.001) and ileus and postoperative peritonitis in comparison to severe acute pancreatitis associated with decreased mortality (OR, 0.2; 95% CI, 0.1-0.4; p < 0.001; OR, 0.5; 95% CI, 0.3-0.8; p = 0.009). Kaplan-Meier analysis showed increased survival in patients treated with VACM in comparison with other TAC methods (LogRank p = 0.019). CONCLUSION
   We report superior role for VACM methodology in terms of successful primary fascial closure and increased survival in patients with OA.
C1 [Rasilainen, Suvi; Mentula, Panu; Leppaniemi, Ari] Helsinki Univ Hosp, Dept Abdominal Surg, Abdominal Ctr, Helsinki, Finland.
   [Rasilainen, Suvi; Mentula, Panu; Leppaniemi, Ari] Univ Helsinki, Helsinki, Finland.
   [Salminen, Paulina; Strander, Tapani] Univ Turku, Turku Univ Hosp, Div Digest Surg & Urol, Dept Surg, Turku, Finland.
   [Salminen, Paulina; Haikonen, Jyrki; Strander, Tapani] Satakunta Cent Hosp, Dept Surg, Pori, Finland.
   [Koivukangas, Vesa] Oulu Univ Hosp, Dept Abdominal Surg, Oulu, Finland.
   [Hyoty, Marja; Mantymaki, Leena-Mari] Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland.
   [Pinta, Tarja] Seinajoki Cent Hosp, Dept Surg, Seinajoki, Finland.
   [Rintala, Jukka] Lapland Cent Hosp, Dept Surg, Rovaniemi, Finland.
   [Rantanen, Tuomo] Univ Eastern Finland, Inst Clin Med, Kuopio Univ Hosp, Dept Surg, Kuopio, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Turku; Satakunta Central Hospital; University
   of Oulu; Tampere University; Tampere University Hospital; Seinajoki
   Central Hospital; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital
RP Rasilainen, S (通讯作者)，Jorvi Hosp, HUCH Abdominal Ctr, Turuntie 150, Espoo 02740, Finland.
EM suvi.rasilainen@hus.fi
RI Salminen, Paulina/ABB-8883-2020; Mentula, Panu/H-9025-2019; Leppäniemi,
   Ari/GQZ-7991-2022
OI Salminen, Paulina/0000-0001-6435-9264; Mentula,
   Panu/0000-0002-6516-3797; Rintala, Jukka/0000-0003-1865-8444; 
FU Helsinki University Hospital Research grant for emergency abdominal
   surgery
FX This study was financially supported by a Helsinki University Hospital
   Research grant for emergency abdominal surgery.
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NR 22
TC 16
Z9 20
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD DEC
PY 2020
VL 89
IS 6
BP 1136
EP 1142
DI 10.1097/TA.0000000000002889
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA OZ3WN
UT WOS:000594860700033
PM 32701909
OA Green Submitted, Green Accepted
DA 2026-07-24
ER

PT J
AU Rupp, M
   Popp, D
   Alt, V
AF Rupp, Markus
   Popp, Daniel
   Alt, Volker
TI Prevention of infection in open fractures: Where are the pendulums now?
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
ID OPEN TIBIAL FRACTURES; PRESSURE WOUND THERAPY; BONE MORPHOGENETIC
   PROTEIN-2; SURGICAL SITE INFECTIONS; VANCOMYCIN POWDER;
   ANTIBIOTIC-PROPHYLAXIS; INITIAL MANAGEMENT; PULSATILE LAVAGE;
   LOWER-LIMB; GENTAMICIN
AB Soft tissue management and fracture fixation including initial external fixation in Gustilo-Anderson type II and type III open fractures are cornerstones in the treatment but details on timing and type of wound closure, irrigation and debridement, systemic and local antibiotics, antimicrobial-coated implants and the use of Bone Morphogenetic Protein-2 remain controversial. This article looks at current clinical evidence of these items for the management of open fractures. Timing of debridement and wound closure remains critical. Early debridement by an experienced team within 24 h seems adequate while gross contam-ination, a devascularized limb, a multi-injured patient and compartment syndrome require immediate surgical intervention. Wound closure during the first surgery was shown to result in reduced rates for infections and nonunion. If soft-tissue reconstruction is needed, it should be performed within the first 7 days. Regarding types of irrigation fluid, antiseptic and antibacterial solutions did not prove to be su-perior to saline. High pressure irrigation has not been demonstrated to be beneficial whereas antibiotic administration as soon as possible has been proven to be favorable. Administration of more than 72 h was not superior to shorter systemic antibiotic intervals. For Gustilo-Anderson type I and II, broad spec-trum antibiotic therapy is reasonable. Additional aminoglycosides for broader coverage are recommended in Gustilo-Anderson type III fractures. There is newer literature on the beneficial effects of the use of local antibiotics, e.g. by antibiotic beads. Coating of internal fixation devices is a modern approach to im-prove infection prophylaxis and gentamicin-coated implants have been demonstrated to be safe in clinical application. Vacuum assisted closure (VAC) could not evidence negative pressure wound therapy to re-duce infection risk, improve self-rated disability or quality of life in open fractures, however, enhance treatment costs. Recombinant human bone morphogenetic proteins (rhBMP)-2 showed promising data in Gustilo-Anderson type III open tibial shaft fractures with lower rates of invasive secondary procedures. In conclusion, there is evidence for thorough debridement and irrigation with saline, early soft tissue cover-age and the use of systemic and local antibiotics. Except for a short-term soft tissue coverage VAC seems not to be beneficial and rhBMP-2 is an additional tool in Gustilo-Anderson type III open fractures. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Rupp, Markus; Popp, Daniel; Alt, Volker] Univ Med Ctr Regensburg, Dept Trauma Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Alt, V (通讯作者)，Univ Med Ctr Regensburg, Dept Trauma Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
EM volker.alt@ukr.de
RI Rupp, Markus/ABH-5784-2022
OI Rupp, Markus/0000-0001-7221-3783
FU Osteosynthesis and Trauma Care Foundation (OTCF); Stryker
FX This paper is part of a supplement supported by the Osteosynthesis and
   Trauma Care Foundation (OTCF) through a research grant from Stryker.
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NR 71
TC 70
Z9 92
U1 0
U2 10
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD MAY
PY 2020
VL 51
SU 2
BP S57
EP S63
DI 10.1016/j.injury.2019.10.074
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA OA1OD
UT WOS:000577563000012
PM 31679836
DA 2026-07-24
ER

PT J
AU Klein, RJ
AF Klein, Robert J.
TI Use of Oxidized Regenerated Cellulose (ORC)/Collagen/Silver-ORC
   Dressings Alone or Subsequent to Advanced Wound Therapies in Complex
   Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE oxidized regenerated cellulose; collagen; silver; dressings; negative
   pressure wound therapy; diabetic foot ulcer; traumatic wound; surgical
   dehiscence
ID MINIMALLY INVASIVE TOOL; TISSUE
AB Introduction. Chronic or senescent wounds are difficult to heal and often require a multi modal treatment plan. Negative pressure wound therapy (NPWT) or advanced wound dressings, such as oxidized regenerated cellulose (ORC)/collagen/ silver-ORC dressings, can be used to promote granulation tissue development and stimulate wound healing in these complex wounds. Objective. This article examines the use of ORC/collagen/silver-ORC dressings alone or subsequent to advanced wound therapies in a retrospective cohort of 24 patients.Materials and Methods. Wounds were assessed upon presentation. If necessary, oral and/or intravenous antibiotics were administered.Each wound underwent sharp debridement. Patients received either ORC/collagen/silver-ORC dressings with a secondary dressing alone or following NPWT. Skin substitutes and epidermal grafting also were utilized to promote wound healing and wound size reduction.Results. Twenty-four patients with an average age of 66.8 +/- 12.7 years were treated. The most prevalent comorbidities were hypertension,diabetes, obesity, peripheral neuropathy, hyperlipidemia, coronary heart disease, and tobacco use. Wound types (N = 27) included diabetic foot ulcers, surgical wounds, traumatic wounds, an ulcer (secondary to chronic gout with tophi), and thermal burns. All 27 wounds fully closed, with an average time to heal of 65.5 +/- 41.5 days. Conclusions. Use of advanced treatment modalities including NPWT, epidermal grafting, and ORC/collagen/silver-ORC dressings contributed to wound healing in these patients with complex and/or chronic wounds.
C1 [Klein, Robert J.] Collom & Carney Clin Assoc, Texarkana, TX USA.
   [Klein, Robert J.] Prisma Hlth, Greenville, SC USA.
C3 Prisma Health
RP Klein, RJ (通讯作者)，200 Patewood Dr,Suite C300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
CR Alavi A, 2010, ADV SKIN WOUND CARE, V23, P132, DOI 10.1097/01.ASW.0000363515.09394.66
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NR 30
TC 6
Z9 7
U1 0
U2 11
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2020
VL 32
IS 2
BP 37
EP 43
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5JC
UT WOS:000519745700002
PM 32155120
DA 2026-07-24
ER

PT J
AU Wang, R
   Thayer, P
   Goldstein, A
   Wagner, WD
AF Wang, Rui
   Thayer, Patrick
   Goldstein, Aaron
   Wagner, William D.
TI Interaction of material stiffness and negative pressure to enhance
   differentiation of bone marrow-derived stem cells and osteoblast
   proliferation
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE bone repair material (BRM); chondroitin sulfate (CS); extracellular
   matrix (ECM); mesenchymal stem cells (MSCs); negative pressure wound
   therapy; poly (octanediol citrate) (POC); type I collagen (COL);
   vacuum-assisted wound closure
ID CHONDROITIN SULFATE; OSTEOGENESIS; EXPRESSION; MECHANISMS; ELASTOMERS;
   SCAFFOLDS; GENES; TIME
AB Negative pressure wound therapy (NPWT) results in improved wound repair and the combined use of NPWT with elastomeric materials may further stimulate and accelerate tissue repair. No firmly established treatment modalities using both NPWT and biomaterials exist for orthopedic application. The goal of this study was to investigate the response of osteoblasts and bone marrow-derived mesenchymal stem cells to negative pressure and to determine whether a newly developed elastic osteomimetic bone repair material (BRM), a blend of type I collagen, chondroitin 6-sulfate, and poly (octanediol citrate) could enhance the osteoblastic phenotype. The results indicate that proliferation and alkaline phosphatase activity of hFOB1.19 osteoblasts were significantly increased with exposure to 12 hr of negative pressure (-125 mmHg). Follow-on studies with rat and human mesenchymal stem cells confirmed that negative pressure enhanced osteoblastic maturation. In addition, a significant interaction of negative pressure and electrospun BRM resulted in increased mRNA expression of alkaline phosphatase, osteopontin, collagen1 alpha 2, and HIF1 alpha, whereas little or no effect on these genes was observed on electrospun collagen or tissue culture plastic. Together, these results suggest that the use of this novel biomaterial, BRM, with NPWT may ultimately translate into a safe and cost-effective clinical application to accelerate bone repair.
C1 [Wang, Rui; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Plast & Reconstruct Surg, Winston Salem, NC USA.
   [Wang, Rui; Thayer, Patrick; Goldstein, Aaron] Wake Forest Univ, Sch Biomed Engn & Sci, Virginia Tech, Biomed Engn & Sci, Winston Salem, NC USA.
   [Goldstein, Aaron] Virginia Tech, Dept Chem Engn, Blacksburg, VA USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Virginia
   Polytechnic Institute & State University; Wake Forest University;
   Virginia Polytechnic Institute & State University
RP Wagner, WD (通讯作者)，Dept Plast & Reconstruct Surg, 112 Nutr Bldg,Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM wwagner@wakehealth.edu
RI ; /AAA-2005-2021
OI Wagner, William/0000-0002-0405-9953; 
FU Center for Nanotechnology and Molecular Materials of Wake Forest
   University; Plastic and Reconstructive Surgery Department of Wake Forest
   University School of Medicine
FX Center for Nanotechnology and Molecular Materials of Wake Forest
   University; Plastic and Reconstructive Surgery Department of Wake Forest
   University School of Medicine
CR Birdwhistell KE, 2018, J KNEE SURG, V31, P410, DOI 10.1055/s-0037-1603801
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   Wang JG, 2005, LIFE SCI, V76, P2817, DOI 10.1016/j.lfs.2004.10.050
   Yang J, 2004, ADV MATER, V16, P511, DOI 10.1002/adma.200306264
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NR 30
TC 9
Z9 11
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-6254
EI 1932-7005
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD FEB
PY 2020
VL 14
IS 2
BP 295
EP 305
DI 10.1002/term.2993
EA JAN 2020
PG 11
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA KN2NG
UT WOS:000506371400001
PM 31845531
DA 2026-07-24
ER

PT J
AU Karl, T
   Woeste, S
AF Karl, T.
   Woeste, S.
TI Prevention of inguinal wound healing disorders in vascular surgery.
   Results of using an epidermal negative pressure system (Prevena™)
SO GEFASSCHIRURGIE
LA German
DT Article
DE Wound healing disorders in the groin; Prevention; Negative pressure
   wound therapy (NPWT); Graft infection; Cost-benefit analysis
AB Complications of wound healing and wound infections (surgical site infections) are a serious problem after surgery. Consequences for patients include a reduction in quality of life, a threat to the therapy outcome, an increased length of stay in hospital and increased mortality. For the hospital substantial additional costs of up to 80,000 US$ have been reported, which are not adequately funded by the German diagnosis-related groups (G-DRG) system. Based on the worldwide positive experience of negative pressure wound therapy (NPWT) a new device is now available to reduce the incidence of wound healing complications after surgery by prophylactic use of an epidermal NPWT system (Prevena (TM) Incision Management System, Kinetic Concepts, San Antonio, Tx). In our case study (n = 14), the effectiveness and the economic benefits of the Prevena (TM) system after inguinal vascular access compared to a historical collective group were analyzed. The system was used only in patients with a risk score a parts per thousand yenaEuro parts per thousand 4 points. In the Prevena (TM) group there were no wound healing disorders and in the control group one patient (7.14%) developed a wound infection. From an economic point of view, the increased costs by the prophylactic use of the Prevena (TM) system are justified by surgery with a high incidence of wound healing disorders and infections and at the same time high resulting costs in high-risk patients.
C1 [Karl, T.; Woeste, S.] Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, D-60316 Frankfurt, Germany.
RP Karl, T (通讯作者)，Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, Konigswarterstr 16, D-60316 Frankfurt, Germany.
EM dr.t.karl@web.de
CR [Anonymous], SURG SIT INF PREV TR
   Bandyk DF, 2000, VASCULAR SURG, P733
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Exton RJ, 2007, EUR J VASC ENDOVASC, V34, P188, DOI 10.1016/j.ejvs.2007.03.012
   Kipaldi DV, 2011, WOUND REPAIR REGEN, V19, P588
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Zeeuw J, 2007, MED KLIN, V102, P858
   Zegelman M, 2008, LEITLINIEN GEFASSINF
NR 8
TC 7
Z9 7
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0948-7034
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD MAR
PY 2013
VL 18
IS 2
BP 120
EP 125
DI 10.1007/s00772-012-1046-z
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 113BG
UT WOS:000316640200011
DA 2026-07-24
ER

PT J
AU Jiang, XY
   Li, N
   Yuan, Y
   Yang, C
   Chen, Y
   Ma, Y
   Wang, JB
   Du, DY
   Boey, J
   Armstrong, DG
   Deng, WQ
AF Jiang, Xiaoyan
   Li, Ning
   Yuan, Yi
   Yang, Cheng
   Chen, Yan
   Ma, Yu
   Wang, Jianbai
   Du, Dingyuan
   Boey, Johnson
   Armstrong, David G.
   Deng, Wuquan
TI Limb Salvage and Prevention of Ulcer Recurrence in a Chronic Refractory
   Diabetic Foot Osteomyelitis
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetic foot ulcer; osteomyelitis; antibiotic-loaded bone cement;
   autologous platelet-rich gel; negative-pressure wound therapy; of
   floading footwear
ID PLATELET-RICH PLASMA; PLANTAR PRESSURE; MANAGEMENT; ISCHEMIA; INFECTION;
   OUTCOMES; PATIENT; CARE
AB Biomechanical changes caused by structural foot deformities predispose patients to plantar ulceration. Plantar ulcer recurrence often leads to osteomyelitis, which is more commonly observed in patients with diabetes. Once the infection of diabetic foot ulcer (DFU) spreads and is complicated by osteomyelitis, treatment becomes more complicated and difficult. Osteomyelitis treatment remains challenging because of low drug concentration within the tissue caused by poor circulation and inadequate localized nutrition. Moreover, tissues around plantar ulcers are fewer and are thin, making the formation of granulation tissues difficult due to elevated plantar pressure. Furthermore, the skin around the wound is excessively keratinized, and the epidermis is hard to regenerate. Meanwhile, skin grafting at that site is often not successful due to poor blood circulation. Therefore, it is technically challenging to manage diabetic pressure plantar ulcer with osteomyelitis and prevent its recurrence. Here, we present a case of chronic DFU complicated by osteomyelitis due to foot deformity. The ulcer was successfully healed using advanced wound repair technology comprising of surgical bone resection, vancomycin-loaded bone cement implant, negative - pressure wound therapy, and autologous platelet -rich gel. Subsequently, preventive foot care with custom-made of floading footwear was prescribed. The plantar ulcer did not recur and improvement in biomechanical parameters was observed after the intervention. This case represents an effective and comprehensive management strategy for limb salvage and pre- vention in patients with complicated foot conditions.
C1 [Jiang, Xiaoyan; Li, Ning; Yuan, Yi; Yang, Cheng; Chen, Yan; Ma, Yu; Deng, Wuquan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Nephrol,Diabet Foot Ctr, Chongqing, Peoples R China.
   [Wang, Jianbai; Du, Dingyuan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Traumatol,Diabet Foot Ctr, Chongqing, Peoples R China.
   [Boey, Johnson] Natl Univ Singapore Hosp, Dept Podiatry, Singapore, Singapore.
   [Armstrong, David G.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USA.
C3 Chongqing University; Chongqing University; National University of
   Singapore; University of Southern California
RP Deng, WQ (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Nephrol, 1 Jiankang Rd, Chongqing 400014, Peoples R China.
EM wuquandeng@gmail.com
RI Boey, Johnson/AAR-2853-2020
OI Boey, Johnson/0000-0001-9466-7241
FU Fundamental Research Funds for the Central Universities at Chongqing
   University [2019CDYGYB020]; Joint Medical Research Programs for
   Chongqing Municipal Science and Technology Bureau and Health Commission
   [2019MSXM028]; National Center for Advancing Translational Sciences
   [UL1TR001855] Funding Source: NIH RePORTER
FX This study was supported by the Fundamental Research Funds for the
   Central Universities at Chongqing University (Grant No.2019CDYGYB020)
   and the Joint Medical Research Programs for Chongqing Municipal Science
   and Technology Bureau and Health Commission (Grant No.2019MSXM028)
   awarded to Dr. Wuquan Deng and Xiaoyan Jiang.
CR Abbott CA, 2002, DIABETIC MED, V19, P377, DOI 10.1046/j.1464-5491.2002.00698.x
   Ahmed M, 2017, ANN VASC SURG, V38, P206, DOI 10.1016/j.avsg.2016.04.023
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NR 37
TC 13
Z9 18
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 2289
EP 2296
DI 10.2147/DMSO.S254586
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MI5KM
UT WOS:000547446600002
PM 32636663
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Arundel, C
   Fairhurst, C
   Corbacho-Martin, B
   Buckley, H
   Clarke, E
   Cullum, N
   Dixon, S
   Dumville, J
   Firth, A
   Hendetson, E
   Lamb, K
   McGinnis, E
   Oswald, A
   Goncalves, PS
   Soares, MO
   Stubbs, N
   Chetter, 
AF Arundel, C.
   Fairhurst, C.
   Corbacho-Martin, B.
   Buckley, H.
   Clarke, E.
   Cullum, N.
   Dixon, S.
   Dumville, J.
   Firth, A.
   Hendetson, E.
   Lamb, K.
   McGinnis, E.
   Oswald, A.
   Goncalves, P. Saramago
   Soares, M. O.
   Stubbs, N.
   Chetter, I
TI Pilot feasibility randomized clinical trial of negative-pressure wound
   therapy versus usual care in patients with surgical wounds
   healing by secondary intention
SO BJS OPEN
LA English
DT Article
AB Background: Surgical wounds healing by secondary intention (SWHSI) are increasingly being treated with negative-pressure wound therapy (NPWT) despite a lack of high-quality research evidence regarding its clinical and cost-effectiveness. This pilot feasibility RCT aimed to assess the methods for and feasibility of conducting a future definitive RCT of NPWT for the treatment of SWHSI.
   Methods: Eligible consenting adult patients receiving care at the study sites (2 acute and 1 community) and with a SWHSI appropriate for NPWT or wound dressing treatment were randomized 1:1 centrally to receive NPWT or usual care (no NPWI). Participants were followed up every 1-2 weeks for 3 months. Feasibility (recruitment rate, time to intervention delivery) and clinical (time to wound healing) outcomes were assessed.
   Results: A total of 248 participants were screened for eligibility; 40 (16.1 per cent) were randomized, 19 to NPWT and 21 to usual care. Twenty-four of the 40 wounds were located on the foot. Participants received NPWT for a median of 18 (range 0-72) days. Two participants in the NPWT group never received the intervention and 14 received NPWT within 48 h of randomization. Five participants in the usual care group received NPWT during the study. Ten of the 40 wounds were deemed to have healed during the study.
   Conclusion: A full-scale RCT to investigate the clinical and cost-effectiveness of NPWT for SWHSI is feasible. This study identified crucial information on recruitment rates and data collection methods to consider during the design of a definitive RCT.
C1 [Arundel, C.; Fairhurst, C.; Corbacho-Martin, B.; Buckley, H.] Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
   [Goncalves, P. Saramago; Soares, M. O.; Chetter, I] Univ York, Ctr Hlth Econ, York, N Yorkshire, England.
   [Clarke, E.; Firth, A.; Oswald, A.] Hull & East Yorkshire Hosp NHS Trust, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.
   [Dixon, S.] Patient & Publ Involvement Grp, Kingston Upon Hull, N Humberside, England.
   [Hendetson, E.] Hull & East Yorkshire Hosp NHS Trust, Outpatient Serv, Kingston Upon Hull, N Humberside, England.
   [Chetter, I] Hull York Med Sch, Res Off, Kingston Upon Hull, N Humberside, England.
   [Cullum, N.; Dumville, J.] Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Cullum, N.] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Res & Innovat Div, Manchester, Lancs, England.
   [Lamb, K.; Stubbs, N.] Leeds Community Healthcare NHS Trust, Leeds Wound Res Unit, Leeds, W Yorkshire, England.
   [McGinnis, E.] Leeds Teaching Hosp NHS Trust, Dept Tissue Viabil, Leeds, W Yorkshire, England.
C3 University of York - UK; University of York - UK; University of Hull;
   University of York - UK; University of Hull; University of Manchester;
   University of Manchester; University of Leeds
RP Arundel, C (通讯作者)，Univ York, Dept Hlth Sci, York Trials Unit, York YO10 5DD, N Yorkshire, England.
EM catherine.arundel@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023; Cullum,
   Nicky/F-2438-2011; McGinnis, Elizabeth/PNF-2864-2026; Buckley,
   Hannah/QAX-3702-2026; Dumville, Jo/O-7867-2014
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Arundel,
   Catherine/0000-0003-0512-4339; McGinnis, Elizabeth/0000-0002-2848-9149;
   chetter, ian/0000-0002-2566-6859; 
FU National Institute for Health Research (NIHR) Programme Grants for
   Applied Research (PGfAR) programme [RP-PG-0609-10171]; National
   Institute for Health Research [NF-SI-0512-10028, NF-SI-0617-10129,
   RP-PG-0609-10171] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This project was funded by the National Institute for Health Research
   (NIHR) Programme Grants for Applied Research (PGfAR) programme (project
   number RP-PG-0609-10171). The views and opinions in this publication are
   those of the authors and do not necessarily reflect those of the NHS,
   the NIHR, the Medical Research Council, the NIHR Central Commissioning
   Facility, the NIHR Evaluation, Trials and Studies Coordinating Centre,
   the PGfAR programme or the Department of Health.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 19
TC 7
Z9 8
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JUN
PY 2018
VL 2
IS 3
BP 99
EP 111
DI 10.1002/bjs5.49
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HC8XZ
UT WOS:000452090000002
PM 29951633
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sekác, J
   Koller, T
   Bujnáková, J
   Durdík, S
AF Sekac, Jaroslav
   Koller, Tomas
   Bujnakova, Julia
   Durdik, Stefan
TI Modern Concepts of the Diagnosis and Treatment of Necrotizing
   Fasciitis-Review of 30 Cases
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Necrotizing fasciitis; Early surgery; Negative pressure wound therapy;
   Prognostic score; Point-of-care ultrasound; Single-center study
ID EMERGENCY-DEPARTMENT; TISSUE; MORTALITY; MICROBIOLOGY; PREDICTORS; LIMB
AB BackgroundNecrotizing fasciitis (NF) is a rare, severe and often lethal soft-tissue infection.ObjectiveThe objective of this retrospective study was to analyze the incidence, clinical outcomes of NF in our region compared to the global data and to review modern surgical techniques, in particular, negative pressure wound therapy (NPWT). The secondary aim was to assess whether LRINEC scoring had prognostic value.MethodsThe study reviews 30 cases of histologically confirmed NF in the period of 2014 to 2023. We have evaluated demographic data, comorbidities, microbiological findings, surgical timing, and treatment outcomes.ResultsThe incidence of NF in our medical center was elevated in comparison to other literature reports, likely due to improved diagnostics. The mortality rate was 3.3%, which was lower compared to the global average (20-40%), which may be related to early diagnosis and prompt surgical intervention in our center. Given the small sample, this finding must be interpreted descriptively. NPWT was used in approximately half of cases as a selective adjunct to wound care and was associated with favorable wound healing and functional outcomes. In more than half of the cases, the LRINEC score exceeded 8, but no significant correlation with mortality was observed.ConclusionTo our knowledge, this study proposes one of the more comprehensive studies analyzing NF in Central Europe. Early surgical exploration combined with NPWT was associated with excellent outcomes in our cohort and may provide a useful framework for further evaluation of NF management strategies.
C1 [Sekac, Jaroslav; Bujnakova, Julia] Comenius Univ, Fac Med, Clin Surg, Bratislava 81372, Slovakia.
   [Koller, Tomas] Comenius Univ, Fac Med, Clin Internal Med, Bratislava 81372, Slovakia.
   [Durdik, Stefan] Comenius Univ, Fac Med, Clin Oncol & Surg, Bratislava 81250, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava
RP Sekác, J (通讯作者)，Comenius Univ, Fac Med, Clin Surg, Bratislava 81372, Slovakia.
EM jaroslavsekac@yahoo.com
CR Abdalla TSA, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0285048
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NR 42
TC 0
Z9 0
U1 3
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD JAN
PY 2026
VL 127
IS 1
BP 311
EP 322
DI 10.1007/s44411-025-00456-3
EA DEC 2025
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DA9DU
UT WOS:001632319200001
OA gold
DA 2026-07-24
ER

PT J
AU Zheng, Z
   Yu, HQ
   Liu, L
   Sui, JH
   Hou, YJ
   Chen, MC
   Liu, R
   Meng, XC
   Ding, C
   Zhang, H
AF Zheng, Zhong
   Yu, Huiqi
   Liu, Lu
   Sui, Junhao
   Hou, Yijin
   Chen, Mengchen
   Liu, Rong
   Meng, Xiangchao
   Ding, Chen
   Zhang, Hao
TI Electroactive Dressing Induces Piezoelectric Signals and
   Ca2+ Activation to Enhance Osteoblast
   Differentiation and Bone Regeneration in Negative Pressure Therapy
SO ADVANCED FUNCTIONAL MATERIALS
LA English
DT Article; Early Access
DE bone regeneration; electric field coupling; electroactive dressing;
   electrolyte trapping; negative-pressure wound therapy; open fracture
ID WOUND THERAPY; BIOMATERIALS; SYSTEMS
AB Negative-pressure wound therapy plays a pivotal role in treating open bone fractures. However, the loss of bioelectricity during the healing process significantly delays tissue repair. The generation and maintenance of bioelectric fields require a complex interplay of multiple factors. Previous attempts to regenerate the lost bioelectric field using exogenous conductive materials or supplementing endogenous functional electrolytes have limited success. During this study, a novel electroactive dressing is formulated tailored for negative-pressure therapy by combining piezoelectric poly L-lactic acid doped with bioactive glass and amino-terminated dendritic macromolecules. When subjected to negative pressure, the mechanical deformation of the dressing generates exogenous piezoelectric signals that effectively couple with the endogenous ionic electric fields. Furthermore, the amine-terminated poly(amidoamine) dendritic macromolecules capture cations via coordination and ion-exchange mechanisms, thus retaining electrolytes at the wound site. The findings indicate that the bioelectricity generated by the electroactive dressing under negative pressure facilitates the influx of calcium ions into cells. Calcium ions bind calmodulin, activating Ca-2(+)/calmodulin-dependent kinase II, which further activates phosphatidylinositol3-kinase (PI3K), initiating the PI3K/Akt pathway and enhancing osteoblast activity. The efficacy of the developed electroactive dressing is verified using a critical-sized cranial bone-defect model in rats, demonstrating its significant osteogenic differentiation potential. The exogenous and endogenous fields provided by the electroactive dressing maintain the electrophysiological state necessary for bone regeneration, providing a novel therapeutic approach for clinical open fractures.
C1 [Zheng, Zhong; Liu, Lu; Sui, Junhao; Hou, Yijin; Chen, Mengchen; Ding, Chen; Zhang, Hao] Navy Mil Med Univ, Changhai Hosp, Dept Traumat Orthoped, 168 Changhai Rd, Shanghai 200433, Peoples R China.
   [Yu, Huiqi; Liu, Rong] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China.
   [Meng, Xiangchao] Fudan Univ, Minhang Hosp, Dept Orthoped, 170 Xinsong Rd, Shanghai 201199, Peoples R China.
C3 Naval Medical University; University of Shanghai for Science &
   Technology; Fudan University
RP Ding, C; Zhang, H (通讯作者)，Navy Mil Med Univ, Changhai Hosp, Dept Traumat Orthoped, 168 Changhai Rd, Shanghai 200433, Peoples R China.; Meng, XC (通讯作者)，Fudan Univ, Minhang Hosp, Dept Orthoped, 170 Xinsong Rd, Shanghai 201199, Peoples R China.
EM mengxiangchao@alumni.sjtu.edu.cn; lingtongkong@smmu.edu.cn;
   zhanghsmmu@smmu.edu.cn
RI Meng, Xiangchao/L-3099-2018; Ding, chenzhi/NQF-9844-2025; Zhang,
   Hao/AAK-8111-2020
OI Meng, Xiangchao/0009-0009-6940-6782; Zhang, Hao/0000-0002-6347-2764
FU Science and Technology Innovation Plan Of Shanghai Science and
   Technology Commission [81872171]; National Natural Science Foundation of
   China [22S31900400]; Shanghai Science and Technology Innovation Action
   Plan [2023MHPY01]; Youth Program of Minhang Hospital [2025MWTZA04];
   Shanghai Minhang District Medical Specialty Construction Project
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81702666), the National Natural Science Foundation of
   China (Grant No. 81872171), the Shanghai Science and Technology
   Innovation Action Plan (Grant No. 22S31900400), the Youth Program of
   Minhang Hospital (2023MHPY01), and Shanghai Minhang District Medical
   Specialty Construction Project (2025MWTZA04).
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NR 50
TC 7
Z9 7
U1 24
U2 61
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1616-301X
EI 1616-3028
J9 ADV FUNCT MATER
JI Adv. Funct. Mater.
PD 2025 JUN 9
PY 2025
DI 10.1002/adfm.202507082
EA JUN 2025
PG 20
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 3TA5H
UT WOS:001508311500001
DA 2026-07-24
ER

PT J
AU Arellano, ML
   Serrano, CB
   Guedea, M
   Pérez, JCG
   Ortega, GS
   Guevara-Martinez, J
   Abril, SG
   Puga, CG
   Arroyo, A
   Cid, RC
AF Leon Arellano, Miguel
   Barragan Serrano, Cristina
   Guedea, Manuela
   Garcia Perez, Juan Carlos
   Sanz Ortega, Gonzalo
   Guevara-Martinez, Jenny
   Gomez Abril, Segundo
   Gonzalez Puga, Cristina
   Arroyo, Antonio
   Cantero Cid, Ramon
TI Surgical Wound Complications after Colorectal Surgery with Single-Use
   Negative-Pressure Wound Therapy Versus Surgical Dressing over Closed
   Incisions: A Randomized Controlled Trial
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE colorectal surgery; complications; incision; negative-pressure wound
   therapy; surgical site infection; surgical dressing; wound healing
ID SITE INFECTION REDUCTION
AB BACKGROUND: Global studies indicate that surgical site infections (SSIs) are a major healthcare challenge within hospitals and can have a profound impact on patient quality of life and healthcare costs. Closed-incision negative-pressure therapy (ciNPT) has been reported to provide positive clinical benefits for patients with various incisions, including those following colorectal surgeries.
   METHODS: Investigators performed a prospective, randomized, multicenter trial to evaluate complications of surgical incisions in patients who received a ciNPT dressing versus a conventional surgical dressing (control) over their closed incision following colorectal surgery. The incidence of SSI was determined at 7, 15, and 30 days postsurgery.
   RESULTS: A total of 148 patients participated in the study. Results showed that the SSI rate on day 7 was lower in the ciNPT group versus the control group (10/ 75 [13.3%] vs 17/73 [23.3%]), but this difference was not statistically significant. On day 15, the SSI rate was 12/75 (16.0%) in the ciNPT group versus 21/73 (28.8%) in the control group; however, this difference was only marginally statistically significant (P = .0621). At 1 month, the SSI rate remained lower in the ciNPT group (13/75 [17.3%] vs 21/73 [28.8%], P = .0983) compared with the control group.
   CONCLUSIONS: Future studies with larger population sizes are necessary to determine the impact of ciNPT on patients' incisions after colorectal surgery.
C1 [Leon Arellano, Miguel] Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
   [Barragan Serrano, Cristina] Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Esophagogastr Unit, Madrid, Spain.
   [Guedea, Manuela] Hosp Clin Univ Lozano Blesa, Gen & Digest Surg, Zaragoza, Spain.
   [Garcia Perez, Juan Carlos] Hosp Ramon & Cajal, Gen & Digest Surg, Madrid, Spain.
   [Sanz Ortega, Gonzalo] Hosp Clin San Carlos, Gen & Digest Surg, Madrid, Spain.
   [Guevara-Martinez, Jenny] Hosp Univ La Paz, Madrid, Spain.
   [Gomez Abril, Segundo] Hosp Doctor Pesset, Gen & Digest Surg, Valencia, Spain.
   [Gonzalez Puga, Cristina] Hosp San Cecilio, Gen & Digest Surg, Granada, Spain.
   [Arroyo, Antonio] Hosp Elche, Gen & Digest Surg, Surg, Elche, Spain.
   [Cantero Cid, Ramon] Univ Autonoma Madrid, Med Sci, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Fundacion Jimenez Diaz; Lozano Blesa University
   Clinical Hospital; Hospital Universitario Ramon y Cajal; Hospital
   Clinico San Carlos; Hospital Universitario La Paz; Hospital
   Universitario San Cecilio; Autonomous University of Madrid
RP Arellano, ML (通讯作者)，Hosp Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
RI Lopez, Gregorio/PJC-1805-2026; /K-8904-2014; Leon, Miguel/GPP-6800-2022;
   Gomez-Abril, Segundo/AAB-2955-2019; JUAN CARLOS, GARCIA
   PEREZ/U-8344-2017
OI Gomez-Abril, Segundo/0000-0003-3523-1821; JUAN CARLOS, GARCIA
   PEREZ/0000-0002-0326-7128
CR Anderson DJ, 2014, INFECT CONT HOSP EP, V35, P605, DOI 10.1086/676022
   [Anonymous], 2012, Colorectal Cancer-From Prevention to Patient Care
   Bielby, 2011, WOUNDS UK, V7, P47
   Centers for Disease Control and Prevention, 2019, PUBL CTR DIS CONTR P, V1-36
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   Curran T, 2019, COLORECTAL DIS, V21, P110, DOI 10.1111/codi.14350
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NR 17
TC 9
Z9 10
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2021
VL 34
IS 12
BP 657
EP 661
DI 10.1097/01.ASW.0000756512.87211.13
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA ZB2JJ
UT WOS:000756674400009
PM 34175866
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zelle, BA
   Kore, L
AF Zelle, Boris A.
   Kore, Lydia
TI How Can Negative Pressure Wound Therapy Pay for Itself?-Reducing
   Complications Is Important
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE tibia; fracture; costs; wound management
ID RISK-FACTORS; FRACTURE SURGERY; TIBIAL PLATEAU; INFECTION; REDUCTION;
   HIP; DRESSINGS; FIXATION
AB Introduction: Orthopaedic trauma demonstrates a relatively high rate of surgical site infections (SSI) as compared with other surgical specialties. SSIs provide significant clinical challenges and create significant health care costs. Incisional negative pressure wound therapy (iNPWT) has reduced the risk of SSI in orthopaedic surgery and other surgical specialties. Purpose: The purpose of this study is to investigate potential cost savings with the use of iNPWT (3M Prevena Therapy, 3M, St. Paul, MN) in high-risk orthopaedic trauma patients with closed OTA/AO 41C and 43C fractures. Methods: This is a retrospective cohort study performed at a single, level-1 trauma center using data from a lower extremity fracture registry. Using the results from the registry and baseline infection rates derived from the literature, a health economic model was developed to evaluate the potential cost savings. Results: A total of 79 patients included in the registry underwent open reduction and internal fixation of OTA/AO 41C and 43C fractures. A total of 10.1% developed a SSI. For those who received iNPWT, the rate of SSI was 7.4%. A health economic model suggests that the use of iNPWT may reduce the costs per patient by approximately $1381 to $4436 per patient. Conclusions: This health economic assessment and model suggests that judicious use of iNPWT may reduce health care costs in patients undergoing open reduction and internal fixation of OTA/AO 41C and 43C fractures.
C1 [Zelle, Boris A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed Surg, San Antonio, TX 78229 USA.
   [Kore, Lydia] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX USA.
C3 University of Texas System; University of Texas at San Antonio; Brooke
   Army Medical Center
RP Zelle, BA (通讯作者)，UT Hlth San Antonio, Dept Orthopaed Surg, 7703 Floyd Curl Dr,MC 7774, San Antonio, TX 78229 USA.
EM zelle@uthscsa.edu
FU 3M KCI Inc.
FX The study was partially funded by 3M KCI Inc.
CR Bachoura A, 2011, CLIN ORTHOP RELAT R, V469, P2621, DOI 10.1007/s11999-010-1737-2
   Bullock TS, 2022, J ORTHOP TRAUMA, V36, P111, DOI 10.1097/BOT.0000000000002259
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NR 26
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S31
EP S35
DI 10.1097/BOT.0000000000002427
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400008
PM 35994307
DA 2026-07-24
ER

PT J
AU Delmore, B
   Ayello, EA
AF Delmore, Barbara
   Ayello, Elizabeth A.
TI Ready-to-Use Micronized Human Acellular Dermal Matrix to Accelerate
   Wound Healing in Diabetic Foot Ulcers: A Prospective Randomized Pilot
   Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal matrix; advanced therapy; cellular and; or tissue-based
   product; diabetic foot ulcer; micronized human acellular dermal matrix;
   negative-pressure wound therapy; wound healing
AB OBJECTIVE
   To examine and report clinical outcomes of a ready-to-use micronized dermal matrix for diabetic foot ulcers (DFUs) and compare it to treatment with conventional negative-pressure wound therapy (NPWT) only. METHODS
   The researchers randomly allocated 30 DFUs Wagner grade 2 or higher from 30 adult patients into two groups. The control group (n = 15) was treated with conventional NPWT, and the experimental group (n = 15) was treated with micronized dermal matrix and NPWT. The researchers evaluated the following outcomes: granulation tissue formation, proportion of patients with closed or granulated wounds at 42 and 120 days, achievement of complete wound healing in the 6 months of follow-up, and intervals from enrollment to final surgical procedures. RESULTS
   All 15 wounds treated with the micronized matrix showed healthy granulation tissue without noticeable complications during follow-up. At 42 days, 46.7% of wounds in the experimental group had closed compared with 28.6% in the conventional NPWT group (P = .007). At 120 days, 86.7% of the experimental group had completely closed wounds, compared with 57.1% in the conventional therapy group (P = .040). During the 6-month follow-up period, 93.3% of the experimental group achieved complete wound healing compared with 85.7% of the conventional therapy group (P = .468). CONCLUSIONS
   The healing outcomes for DFUs in the experimental group were superior when micronized matrix treatment was combined with NPWT.
C1 [Delmore, Barbara] NYU Langone Hlth, Ctr Innovat Adv Care CIAC, New York, NY 10016 USA.
   [Ayello, Elizabeth A.] Excelsior Coll Sch Nursing, New York, NY USA.
   [Ayello, Elizabeth A.] Hanford Inst Geriatr Nursing, New York, NY USA.
   [Ayello, Elizabeth A.] Ayello Harris & Associates Inc, New York, NY USA.
C3 NYU Langone Medical Center
RP Delmore, B (通讯作者)，NYU Langone Hlth, Ctr Innovat Adv Care CIAC, New York, NY 10016 USA.
OI Delmore, Barbara/0000-0002-6930-4569
CR Banta MN, 2003, DERMATOL SURG, V29, P863, DOI 10.1046/j.1524-4725.2003.29234.x
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
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NR 15
TC 3
Z9 3
U1 2
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2021
VL 34
IS 5
BP 236
EP 237
DI 10.1097/01.ASW.0000742304.60363.e3
PG 2
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA RP9ZD
UT WOS:000642079200004
PM 33852459
OA hybrid
DA 2026-07-24
ER

PT J
AU Kuril, P
   Mensíková, A
   Búrilová, P
   Saibertová, S
   Pokorná, A
AF Kuril, P.
   Mensikova, A.
   Burilova, P.
   Saibertova, S.
   Pokorna, A.
TI Identification of barriers and benefits of Negative Pressure Wound
   Therapy
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE barriers; benefits -; negative pressure&nbsp; wound therapy;
   retrospective analysis; vacuum therapy
AB Aim: This study aimed to identify barriers and benefits of negative pressure wound therapy (NPWT) in patients at the Department of Surgery of the University Hospital Brno over a five-year period (2017-2021). Methods: Retrospective, observational descriptive study of data from hospital records of patients at the Department of Surgery of the University Hospital Brno. Results: A total of 104 patients who were treated with NPWT were identified in the survey. The mean age of the patients was 66.7 years (Min. age 27, Max. age 93). The mean length of hospitalization was 30.2 days (Min. 6, Max. 145 days) and the mean length of NPWT was 20.6 days (Min. 4, Max. 76 days). In total, 31 patients (29.8%) had the same duration of hospitalization and NPWT application and 27 patients (26%) were simultaneously under a barrier regime. The etiology of the wounds was variable. A gastrointestinal disease in 63.4% (N = 66) of patients, vascular problems in 33.7% (N = 35) and pressure ulcers in 2.9% (N = 3). The frequency of wound swabbing was 4 to 6 days and wound dressing (NPWT) exchange was performed in intervals from 3 to 5 days. The VIVANOTec Pro (R) device was used in all patients. Conclusion: A retrospective analysis over a five-year period showed that NPWT is routinely used in wounds of various etiologies, mostly in polymorbid patients of older age. No adverse effects associated with the use of NPWT were documented in the study group.
C1 [Kuril, P.; Mensikova, A.; Burilova, P.; Saibertova, S.; Pokorna, A.] Masaryk Univ, Fac Med, Dept Hlth Sci, Kamenice 3, Brno 62500, Czech Republic.
   [Kuril, P.; Mensikova, A.; Burilova, P.] Masaryk Univ, Fac Med, Dept Publ Hlth, Brno, Czech Republic.
   [Kuril, P.] Univ Hosp Brno, Dept Surg, Brno, Czech Republic.
C3 Masaryk University; Masaryk University; University Hospital Brno
RP Mensíková, A (通讯作者)，Masaryk Univ, Fac Med, Dept Hlth Sci, Kamenice 3, Brno 62500, Czech Republic.
EM burilova@med.muni.cz
RI Pokorná, Andrea/E-5483-2019; Saibertova, Simona/AAO-7873-2021; Búřilová,
   Petra/AAP-8502-2021
OI Pokorná, Andrea/0000-0002-1305-6455; Menšíková,
   Andrea/0000-0001-8548-6051; Saibertova, Simona/0000-0003-2641-9259; 
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
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   Mervis JS, 2019, J AM ACAD DERMATOL, V81, P893, DOI 10.1016/j.jaad.2018.12.068
   Norman G, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009261.pub6, 10.1002/14651858.CD009261.pub5]
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Pokorna A., 2012, UVOD WOUND MANAGEMEN
   Rezk F, 2019, CONT CLIN TRIAL COMM, V16, DOI 10.1016/j.conctc.2019.100469
   Simek M, 2013, PODTLAKOVA LECBA RAN
   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
NR 16
TC 0
Z9 0
U1 0
U2 7
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2022
VL 85
SU 1
DI 10.48095/cccsnn2022S43
PG 4
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 7R5DM
UT WOS:000910092800001
DA 2026-07-24
ER

PT J
AU Dimofte, F
   Dimofte, C
   Ungurianu, S
   Serban, C
   Tocu, G
   Cârneciu, N
   Filip, I
   Bezman, L
   Fulga, A
   Tutunaru, D
   Abdulan, IM
   Ciuntu, BM
   Mihailov, R
   Vasilescu, AM
   Firescu, D
AF Dimofte, Florentin
   Dimofte, Cristina
   Ungurianu, Sorin
   Serban, Cristina
   Tocu, George
   Carneciu, Nicoleta
   Filip, Iulia
   Bezman, Laura
   Fulga, Ana
   Tutunaru, Dana
   Abdulan, Irina Mihaela
   Ciuntu, Bogdan Mihnea
   Mihailov, Raul
   Vasilescu, Alin Mihai
   Firescu, Dorel
TI The Management of Wound Healing in Infections after Hip Arthoplasty
   Using Stimulan and Negative Pressure Wound Therapy
SO DIAGNOSTICS
LA English
DT Article
DE hip arthroplasty; infection; biocomposite; negative pressure wound
   therapy
ID CALCIUM-SULFATE BEADS; ANTIBIOTIC DELIVERY; ARTHROPLASTY; OSTEOMYELITIS;
   REVISION; SERIES; RISK
AB Background: medical teams continue to face challenges with infections following hip replacement surgery, whether they occur shortly after the procedure or months or years later. Certain medical conditions like diabetes, rheumatoid arthritis, and obesity are risk factors that make patients more susceptible to infections. Traditional intervention methods such as DAIR, one-step, or two-step procedures are being enhanced and refined to ensure quicker and more effective treatment. Some cases present particularly difficult challenges, featuring persistent fistulas and unpredictable responses to treatment. Methods: in our article, we share two unique cases, detailing their histories, progressions, and treatment decisions. We explore the use of antibiotic-impregnated calcium biocomposite as a local adjuvant therapy and the application of negative pressure therapy to expedite healing. The system of NWPT has seen widespread uptake and is now implemented routinely for open wounds, such as open fractures, fasciotomies, ulcers, and infected wounds. Results: our findings demonstrate that surgical debridement and calcium sulfate bead insertion successfully treat bone and joint infections without causing any side effects or complications. As a particularity, in the first case, we encountered the exteriorization of Stimulan pearls after surgery, without other complications related to the biocomposite. Conclusions: we have found that NPWT is a beneficial tool in managing complex wounds in both acute and chronic stages, after the infection is cured, reducing the need for frequent dressing changes, shortening hospital stays, and enhancing patient comfort.
C1 [Dimofte, Florentin; Serban, Cristina; Tocu, George; Carneciu, Nicoleta; Filip, Iulia] St Apostol Andrei Cty Emergency Clin Hosp, Gen Surg Clin, Galati 800578, Romania.
   [Dimofte, Florentin; Ungurianu, Sorin; Fulga, Ana] Dunarea de Jos Univ Galati, Fac Med, Dept Morphol & Funct Sci, Galati 800008, Romania.
   [Dimofte, Cristina] St John Emergency Children Hosp, Dept Radiol, Str Gheorghe Asachi 2, Galati 800487, Romania.
   [Serban, Cristina; Filip, Iulia; Mihailov, Raul; Firescu, Dorel] Fac Med Dunarea de Jos, Dept Gen Surg, Galati 800008, Romania.
   [Tocu, George; Tutunaru, Dana] Fac Med Dunarea de Jos, Dept Lab Med, Galati 800008, Romania.
   [Carneciu, Nicoleta; Bezman, Laura] Fac Med Dunarea de Jos, Dept Ophtalmol, Galati 800008, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Ciuntu, Bogdan Mihnea; Vasilescu, Alin Mihai] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
C3 Dunarea De Jos University Galati; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.; Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
EM florentin.dimofte@ugal.ro; cristina.dimofte90@yahoo.com;
   sorinungurianu@yahoo.com; cristina.serban@ugal.ro; george.tocu@ugal.ro;
   nicoleta.carneciu@ugal.ro; iulia.filip@ugal.ro; laura.bezman@ugal.ro;
   ana.fulgaa@gmail.com; dana_tutunaru_cmgl@yahoo.com;
   irina.abdulan@yahoo.com; bogdanmciuntu@yahoo.com; raul.mihailov@ugal.ro;
   alin.vasilescu@umfiasi.ro; dorelfirescu@yahoo.com
RI Dimofte, Florentin/JXY-0006-2024; Fulga, Ana/AAE-3197-2022; Abdulan,
   Irina/AAA-3089-2020; /AAH-9888-2019; Cârneciu, Nicoleta/IAR-2188-2023;
   Ciuntu, Bogdan/MTF-9477-2025; Firescu, Dorel/AAB-2808-2019; Țocu,
   George/LRB-7068-2024; Vasilescu, Alin Mihai/HPE-4046-2023; Raul,
   Mihailov/IQU-7822-2023
OI Firescu, Dorel/0009-0002-0133-470X; Țocu, George/0000-0002-0953-4274;
   Vasilescu, Alin Mihai/0000-0002-9865-5114; Bezman,
   Laura/0000-0002-2327-1220; Raul, Mihailov/0000-0001-7081-9490
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 29
TC 0
Z9 0
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD OCT
PY 2024
VL 14
IS 19
AR 2206
DI 10.3390/diagnostics14192206
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I7A3U
UT WOS:001331743200001
PM 39410610
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Baldawi, M
   Bogue, S
   Mandapati, R
   Cooper, J
   Rabkin, DG
   Contractor, T
AF Baldawi, Mustafa
   Bogue, Shelly
   Mandapati, Ravi
   Cooper, Joshua
   Rabkin, David G.
   Contractor, Tahmeed
TI Early modified primary closure for treatment of cardiac implantable
   electronic device pocket infections
SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
LA English
DT Article
DE cardiac implantable electronic device; length of stay; negative pressure
   wound therapy; pocket infection; primary closure; re&#8208; infection
AB Background Guidance for wound management of the vacated generator pocket in cardiac implantable electronic device (CIED) pocket infections after removal of all hardware and tissue debridement is limited. The typical surgical technique for management of a purulent wound is to allow healing by secondary intention. An alternative approach uses negative pressure wound therapy with or without delayed primary closure. While effective in managing infection, these approaches increase hospital length of stay and costs. We present our experience with a third option: modified early primary wound closure over a suction device.
   Methods All patients with CIED pocket infections who presented to our institution between September 2018 and October 2020 underwent extraction of hardware and modified primary wound closure over a negative pressure Jackson-Pratt drain. Length of hospital and postoperative stay, complications, and recurrent infections were recorded.
   Results During the study period, 14 patients underwent modified primary wound closure for CIED pocket infections. Mean length of hospital stay was 6.64 days +/- 4.01 days (standard deviation [SD]). Mean postoperative length of stay was 3.92 +/- 2.21 days (SD). Two patients (both on intravenous heparin for mechanical valve prostheses) required re-exploration for bleeding. No patients developed recurrent infection at a mean follow up of 363 +/- 245 days (SD).
   Conclusion Based on our experience, early modified primary wound closure for CIED pocket infections appears to be safe and allows for prompt discharge with no observed re-infections.
C1 [Baldawi, Mustafa; Bogue, Shelly; Rabkin, David G.] Loma Linda Univ, Med Ctr, Dept Cardiothorac Surg, Loma Linda, CA USA.
   [Mandapati, Ravi; Contractor, Tahmeed] Loma Linda Univ, Med Ctr, Div Cardiol, Loma Linda, CA USA.
   [Cooper, Joshua] Temple Univ, Sect Cardiac Electrophysiol, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
C3 Loma Linda University; Loma Linda University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Temple University
RP Contractor, T (通讯作者)，11234 Anderson St,Schuman Pavil,SP-1617, Loma Linda, CA 92354 USA.
EM tahmeedcontractor@gmail.com
RI Rabkin, David/IYT-3118-2023
CR Cabell CH, 2004, AM HEART J, V147, P582, DOI 10.1016/j.ahj.2003.06.005
   Greenspon AJ, 2012, J AM COLL CARDIOL, V60, P1540, DOI 10.1016/j.jacc.2012.07.017
   Greenspon AJ, 2011, J AM COLL CARDIOL, V58, P1001, DOI 10.1016/j.jacc.2011.04.033
   Hansalia R, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002204
   Kusumoto FM, 2017, HEART RHYTHM, V14, pE503, DOI 10.1016/j.hrthm.2017.09.001
   McGarry TJ, 2014, EUROPACE, V16, P372, DOI 10.1093/europace/eut305
   Poller WC, 2012, PACE, V35, P1217, DOI 10.1111/j.1540-8159.2012.03479.x
   Sastry S., 2015, ADV PREV MED, V2015
   Satsu T, 2010, PACE, V33, P426, DOI 10.1111/j.1540-8159.2009.02661.x
   Voigt A, 2006, J AM COLL CARDIOL, V48, P590, DOI 10.1016/j.jacc.2006.05.016
NR 10
TC 0
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0147-8389
EI 1540-8159
J9 PACE
JI PACE-Pacing Clin. Electrophysiol.
PD MAY
PY 2021
VL 44
IS 5
BP 765
EP 772
DI 10.1111/pace.14235
EA APR 2021
PG 8
WC Cardiac & Cardiovascular Systems; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Engineering
GA RZ1GJ
UT WOS:000641075300001
PM 33813740
DA 2026-07-24
ER

PT J
AU Schreiner, W
   Ludolph, I
   Dudek, W
   Horch, RE
   Sirbu, H
AF Schreiner, Waldemar
   Ludolph, Ingo
   Dudek, Wojciech
   Horch, Raymund E.
   Sirbu, Horia
TI Negative Pressure Wound Therapy Combined With Instillation for
   Sternoclavicular Joint Infection
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID SURGICAL-MANAGEMENT
AB Background. There is no consensus on the management of spontaneous sternoclavicular joint infection (SCJI). Negative pressure wound therapy (NPWT) has been widely accepted for SCJI. We reviewed our experience with the management of this condition comparing NPWT alone and NPWT combined with instillation and dwell time.
   Methods. We retrospectively analyzed the data of patients with spontaneous SCJI treated in our thoracic unit.
   Results. From March 2008 to October 2019, 27 patients (21 men and 6 women) underwent NPWT combined with muscle flap transfer after necrosectomy and chest wall resection for SCJI. The median age was 57.1 years (range, 35 to 85). Depending on management, the patients were divided into two groups: 16 patients with NPWT in group 1, and 11 patients with NPWT combined with instillation and dwell time in group 2. The severity of SCJI, extent of chest wall resection, and type of muscle flap were not significantly different (P = .35, P =.858, P = .705, respectively). Median duration of hospital stay and NPWT were shorter in group 2 (30 vs 25 days, and 20 vs 16 days, respectively). The required wound dressing changes were significantly lower in group 2 (P = .008). Statistical trend to higher bacterial eradication in group 2 was noted (P = .093). Postoperative complications including SCJI recurrence, wound seroma, and dehiscence were not significantly different between groups (P = .269).
   Conclusions. The NPWT combined with instillation and dwell time appears a useful strategy in patients with SCJI, leading to higher incidence of bacterial eradication and shorter wound care. (C) 2020 by The Society of Thoracic Surgeons
C1 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Thorac Surg, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Schreiner, W (通讯作者)，Friedrich Alexander Univ Erlangen Nuremberg, Dept Thorac Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM waldemar.schreiner@uk-erlangen.de
RI Schreiner, Waldemar/ABG-9988-2021; /ABB-6254-2020; Horch,
   Raymund/H-8128-2019
CR Abu Arab W, 2011, EUR J CARDIO-THORAC, V40, P630, DOI 10.1016/j.ejcts.2010.12.037
   Burkhart HM, 2003, J THORAC CARDIOV SUR, V125, P945, DOI 10.1067/mtc.2003.172
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   Haddad M, 2002, ANN THORAC SURG, V74, P1225, DOI 10.1016/S0003-4975(02)03815-8
   Horch RE, 2020, EXPERT REV MED DEVIC, V17, P139, DOI 10.1080/17434440.2020.1714434
   Horch RE, 2018, ZBL CHIR, V143, P609, DOI 10.1055/a-0713-0517
   Joethy J, 2012, ARCH PLAST SURG-APS, V39, P643, DOI 10.5999/aps.2012.39.6.643
   Kachala SS, 2016, ANN THORAC SURG, V101, P2155, DOI 10.1016/j.athoracsur.2016.01.054
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   Puri V, 2011, ANN THORAC SURG, V91, P257, DOI 10.1016/j.athoracsur.2010.07.112
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   Schipper P, 2017, THORAC SURG CLIN, V27, P73, DOI 10.1016/j.thorsurg.2017.01.001
   Schreiner W, 2013, ZBL CHIR, V138, P117, DOI 10.1055/s-0032-1315201
   Schreiner W, 2018, PLAST AESTHET RES, V5, P32, DOI 10.20517/2347-9264.2018.45
   Singh D, 2017, WOUNDS, V29, P175
   Song HK, 2002, ANN THORAC SURG, V73, P427, DOI 10.1016/S0003-4975(01)03390-2
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
NR 20
TC 10
Z9 14
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2020
VL 110
IS 5
BP 1722
EP 1725
DI 10.1016/j.athoracsur.2020.04.037
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA OE6OH
UT WOS:000580647400076
PM 32497648
OA Bronze
DA 2026-07-24
ER

PT J
AU Gioco, R
   Sanfilippo, C
   Veroux, P
   Corona, D
   Privitera, F
   Brolese, A
   Ciarleglio, F
   Volpicelli, A
   Veroux, M
AF Gioco, Rossella
   Sanfilippo, Claudio
   Veroux, Pierfrancesco
   Corona, Daniela
   Privitera, Francesca
   Brolese, Alberto
   Ciarleglio, Francesco
   Volpicelli, Alessio
   Veroux, Massimiliano
TI Abdominal wall complications after kidney transplantation: A clinical
   review
SO CLINICAL TRANSPLANTATION
LA English
DT Review
DE biological mesh; component separation; dehiscence; immunosuppression;
   Incisional hernia; infection; kidney transplantation; laparoscopic;
   mesh; negative pressure wound therapy; open; pancreas; paratransplant
   hernia; primary suture; transplantation; wound
ID INCISIONAL HERNIA REPAIR; WOUND-HEALING COMPLICATIONS; RANDOMIZED
   CONTROLLED-TRIAL; DELAYED GRAFT FUNCTION; HOOD FASCIAL CLOSURE;
   RISK-FACTORS; MYCOPHENOLATE-MOFETIL; RENAL-TRANSPLANTATION;
   PARATRANSPLANT HERNIA; POLYPROPYLENE MESH
AB Introduction Abdominal wall complications are common after kidney transplantation, and although they have a minor impact on patient and graft survival, they increase the patient's morbidity and may have an impact on quality of life. Abdominal wall complications have an overall incidence of 7.7-21%. Methods This review will explore the natural history of abdominal wall complications in the kidney transplant setting, with a special focus on wound dehiscence and incisional herni, with a particular emphasis on risk factors, clinical characteristics, and treatment. Results Many patient-related risk factors have been suggested, including older age, obesity, and smoking, but kidney transplant recipients have an additional risk related to the use of immunosuppression. Wound dehiscence usually does not require surgical intervention. However, for deep dehiscence involving the fascial layer with concomitant infection, surgical treatment and/or negative pressure wound therapy may be required. Conclusions Incisional hernia (IH) may affect 1.1-18% of kidney transplant recipients. Most patients require surgical treatment, either open or laparoscopic. Mesh repair is considered the gold standard for the treatment of IH, since it is associated with a low rate of postoperative complications and an acceptable rate of recurrence. Biologic mesh could be an attractive alternative in patients with graft exposition or infection.
C1 [Gioco, Rossella; Privitera, Francesca; Volpicelli, Alessio; Veroux, Massimiliano] Univ Hosp Catania, Gen Surg Unit, Catania, Italy.
   [Sanfilippo, Claudio] Univ Hosp Catania, Cardiol Unit, Catania, Italy.
   [Veroux, Pierfrancesco; Veroux, Massimiliano] Univ Hosp Catania, Organ Transplant Unit, Catania, Italy.
   [Corona, Daniela] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
   [Brolese, Alberto; Ciarleglio, Francesco] Trento Hosp, Surg Unit, Trento, Italy.
C3 University of Catania; University Catania Hospital; University of
   Catania; University Catania Hospital; University of Catania; University
   Catania Hospital; University of Catania
RP Veroux, M (通讯作者)，Univ Hosp Catania, Organ Transplant Unit, Dept Med & Surg Sci & Adv Technol, Via Santa Sofia, I-8495123 Catania, Italy.
EM veroux@unict.it
RI ; Veroux, Massimiliano/K-4821-2018; Veroux, Pierfrancesco/K-5195-2018;
   Ciarleglio, Francesco/ABD-1681-2020
OI Privitera, Francesca/0000-0003-0654-3789; Veroux,
   Massimiliano/0000-0002-2780-6421; Sanfilippo,
   Claudio/0000-0002-1508-4927; Gioco, Rossella/0000-0003-3608-6187
FU Specialty School of General Surgery of the University of Catania;
   University of Catania [FIR-14]
FX The authors thank Dr. Grazia Strazzeri and Dr Domenico Zerbo for their
   valuable contribution in preparing the figures of the manuscript. This
   study was supported by This manuscript was funded by the Specialty
   School of General Surgery of the University of Catania and by the FIR-14
   Research Project of the University of Catania.
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NR 127
TC 19
Z9 24
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0902-0063
EI 1399-0012
J9 CLIN TRANSPLANT
JI Clin. Transplant.
PD DEC
PY 2021
VL 35
IS 12
AR e14506
DI 10.1111/ctr.14506
EA OCT 2021
PG 15
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA XS1UL
UT WOS:000712126900001
PM 34634148
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Allen, D
   LaBarbera, LA
   Bondre, IL
   Lessing, MC
   Rycerz, AM
   Kilpadi, DV
   Collins, BA
   Perkins, J
   McNulty, AK
AF Allen, Diwi
   LaBarbera, Lori A.
   Bondre, Ioana L.
   Lessing, M. Christian
   Rycerz, Anthony M., Jr.
   Kilpadi, Deepak V.
   Collins, Barbara A.
   Perkins, Joanna
   McNulty, Amy K.
TI Comparison of tissue damage, cleansing and cross-contamination potential
   during wound cleansing via two methods: lavage and negative pressure
   wound therapy with instillation
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Environmental cross-contamination; Lavage; NPWTi; Tissue trauma; Wound
   cleansing
ID VANCOMYCIN-RESISTANT ENTEROCOCCI; PULSATILE LAVAGE;
   ACINETOBACTER-BAUMANNII; ENVIRONMENTAL CONTAMINATION;
   STAPHYLOCOCCUS-AUREUS; SOFT-TISSUE; IRRIGATION; INFECTIONS; OUTBREAK;
   SYSTEM
AB The use of lavage was compared to negative pressure wound therapy (NPWT) with instillation (NPWTi) to assess extent of soft tissue damage, debris removal and environmental cross-contamination susceptibility in three distinct models. Scanning electron microscopy in an ex vivo model showed increased visible tissue trauma from lavage treatment at low and high pressures versus NPWTi, with the degree of trauma relative to the pressure of the irrigant. These results were corroborated in granulating full-thickness excisional swine wounds coated with dextran solution to simulate wound debris. Both low-pressure lavage and NPWTi demonstrated effective cleansing in this model, reducing debris by >90%. However, using three-dimensional photography to evaluate tissue damage by measuring immediate tissue swelling (changes in wound volume and depth) showed significantly greater (P < 0.05) swelling in low-pressure lavage-treated wounds compared with NPWTi-treated wounds. Lastly, bench top wound models were inoculated with fluorescent bacterial particles to assess environmental cross-contamination potential and collected at measured distances after treatment with low-pressure lavage and NPWTi. No evidence of cross-contamination was found with NPWTi, whereas one-half of the particles became aerosolised' during low-pressure lavage (P < 0.05). Collectively, these studies demonstrate the effective wound cleansing capabilities of NPWTi without the tissue damage and environmental contamination associated with lavage.
C1 [Allen, Diwi; LaBarbera, Lori A.; Bondre, Ioana L.; Lessing, M. Christian; Rycerz, Anthony M., Jr.; Kilpadi, Deepak V.; Collins, Barbara A.; Perkins, Joanna; McNulty, Amy K.] Kinet Concepts Inc, Act Healing Solut Appl Sci, San Antonio, TX 78249 USA.
RP Allen, D (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM diwi.allen@kci1.com
RI ; Bondre, Ioana/GXF-4790-2022
OI Lessing, Chris/0009-0001-5009-6624; 
FU KCI
FX The authors would like to thank the staff at Surpass preclinical
   facility for their assistance with wound creation and cleansing
   therapies; A. Jimenez of Vel-Lab Research for histology processing; M.
   Manwaring of KCI for his help with the wound template for the ex vivo
   wound model portion of the study and Z. Liu of KCI for statistical
   analyses. This study was supported by KCI. Many of the authors are
   employees of KCI. All authors report no other conflicts of interest
   relevant to this study.
CR Adili A, 2002, J ORTHOP TRAUMA, V16, P413, DOI 10.1097/00005131-200207000-00008
   [Anonymous], COCHRANE DATABASE SY
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NR 30
TC 28
Z9 34
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 198
EP 209
DI 10.1111/j.1742-481X.2012.01073.x
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100014
PM 22905800
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Altaweel, A
   Meselhi, A
   Marzouk, H
   Shahin, HN
   Salim, M
   Mohamed, AM
   Khataybeh, IM
   Seif, AT
   Elbataa, A
   Metwalli, E
   Elgenidy, A
AF Altaweel, Ahmed
   Meselhi, Amr
   Marzouk, Hamza
   Shahin, Hatim N.
   Salim, Moustafa
   Mohamed, Alaa M.
   Khataybeh, Ismail M.
   Seif, Ahmed T.
   Elbataa, Ahmed
   Metwalli, Eslam
   Elgenidy, Anas
TI Effectiveness of Incisional Negative Pressure Wound Therapy in the
   Prevention of Post-Amputation Complications: Systematic Review and
   Meta-Analysis
SO ANNALS OF VASCULAR SURGERY
LA English
DT Review
ID SURGICAL-SITE INFECTIONS; NPWT
AB Background: Negative pressure wound therapy (NPWT) is an advanced therapy utilizing subatmospheric pressure at the wound site to generate a controlled environment that promotes blood flow and stabilizes the wound area. However, its effectiveness in diminishing surgical site complications remains unproven effectively. We aim to assess the impact of incisional NPWT (iNPWT) on the reduction of surgical wound complications, mortality rate, and improvement of healing rate following lower limb amputation. Methods: An extensive search was executed in several databases for relevant studies evaluating iNPWT following lower limb amputation. We used RevMan to calculate pooled risk ratio (RR) for dichotomous outcomes and mean difference (MD) for continuous outcomes with 95% confidence interval (95% CI). The outcomes of our analysis were the assessment of overall post-intervention wound complications, surgical site infection, need for revision surgery, seroma or hematoma formation, 30-day mortality, subsequent amputation, readmission, and the time taken for complete healing. Results: Ten studies, including atotal of 1,003 patients, were included in ouranalysis. The findings indicate asignificant reduction in the riskof overall post-intervention wound complications (RR, 0.41; 95% CI 0.20, 0.84) and a shorter time to complete healing (MD,-1.76 weeks; 95% CI-2.66,-0.86 weeks) compared to the control group. No significant difference was found in wound infection, seroma or hematoma formation, readmission, and mortality rates between the iNPWT and the control groups. Conclusion: iNPWT significantly reduces overall post-intervention wound complications and shortens the time required for complete healing.
C1 [Altaweel, Ahmed] Alexandria Univ, Fac Med, Alexandria, Egypt.
   [Meselhi, Amr] Bedfordshire Hosp NHS Fdn Trust, Bedford Hosp, 14 Meridian House,Kingsway Link, Bedford MK42 0JY, England.
   [Marzouk, Hamza] Jordan Univ Sci & Technol, Irbid, Jordan.
   [Shahin, Hatim N.] South Valley Univ, Fac Med, Qina, Egypt.
   [Salim, Moustafa; Mohamed, Alaa M.] Mansoura Univ, Fac Med, Mansoura, Egypt.
   [Khataybeh, Ismail M.] Prince Rashid Mil Hosp, Irbid, Jordan.
   [Seif, Ahmed T.; Elbataa, Ahmed] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Metwalli, Eslam] Worcestershire Acute Hosp NHS Trust, Redditch, Worcs, England.
   [Elgenidy, Anas] Cairo Univ, Fac Med, Cairo, Egypt.
   [Elgenidy, Anas] Karl Jaspers Klin, Zwishchenahn, Germany.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Jordan University
   of Science & Technology; Egyptian Knowledge Bank (EKB); Qena University;
   Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Al Azhar University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Meselhi, A (通讯作者)，Bedfordshire Hosp NHS Fdn Trust, Bedford Hosp, 14 Meridian House,Kingsway Link, Bedford MK42 0JY, England.
EM amralla41@gmail.com
RI Elgenidy, Anas/AAV-1880-2021
OI Altaweel, Ahmed/0009-0009-7281-5624
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NR 20
TC 1
Z9 2
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD DEC
PY 2025
VL 121
BP 616
EP 632
DI 10.1016/j.avsg.2025.08.027
EA SEP 2025
PG 17
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 7YZ3Y
UT WOS:001583006300004
PM 40912637
DA 2026-07-24
ER

PT J
AU Myers, BA
AF Myers, Beth A.
TI Negative Pressure Wound Therapy With Instillation as an Early
   Intervention for Extensive Wounds From Necrotizing Fasciitis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Abscess; Bacterial infection wounds; Necrotizing fasciitis; Necrotizing
   infection
AB BACKGROUNDMs. S was a 50-year-old woman hospitalized with necrotizing fasciitis from a labial abscess. After several surgical interventions wound debridements were performed consecutively for 6 days. She was left with extensive full thickness tissue destruction of her abdomen, bilateral groin areas, and complete displacement of skin over her mons pubis. Wounds related to necrotizing fasciitis can be especially challenging to manage, especially when the perineal region is involved. Due to the location of such wounds, it can be difficult to maintain dressings, including negative pressure wound therapy with instillation devices (NPWTi). Ms. S. also had a history of uncontrolled diabetes mellitus, which can hinder wound healing.CASEThe Wound, Ostomy and Continence (WOC) nurse was consulted on day 6 of Ms. S's admission, for application of NPWTi. Complex NPWTi dressings were completed in the operating room (OR), 2 times weekly for 2 weeks. When Ms. S was transferred from the intensive care unit to the surgical unit, NPWT dressings with instillation were used but later converted to standard NPWT, changed twice weekly by the WOC nurse. Dressings were changed at the bedside until day 29 of her admission.CONCLUSIONThe management of Ms. S's extensive wounds was successful, and her wounds were closed by plastic surgery on day 29 of her admission. Ms. S was the first patient at our hospital with extensive wounds from necrotizing fasciitis to undergo surgical closure of her wounds during the same hospital admission.
C1 [Myers, Beth A.] Wellspan York Hosp, Trauma Crit Care Wound NP, 1001 South George St, York, PA 17403 USA.
RP Myers, BA (通讯作者)，Wellspan York Hosp, Trauma Crit Care Wound NP, 1001 South George St, York, PA 17403 USA.
EM bmyers@wellspan.org
RI /AAV-2635-2021
CR Amin N, 2023, J WOUND OSTOMY CONT, V50, P203, DOI 10.1097/WON.0000000000000967
   CDC Centers for Disease Control and Prevention, CDC 24/7 Saving Lives. Protecting PeopleTM. The National Diabetes Statistics Report, 2020. Estimates of Diabetes and Its Burden in the United States
   Crumley C, 2021, J WOUND OSTOMY CONT, V48, P199, DOI 10.1097/WON.0000000000000760
   DeGenova Daniel T, 2023, Cureus, V15, pe36576, DOI [10.7759/cureus.36576, 10.7759/cureus.36576]
   Wang GQ, 2023, INT WOUND J, V20, P1739, DOI 10.1111/iwj.13989
NR 5
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2024
VL 51
IS 6
BP 499
EP 506
DI 10.1097/WON.0000000000001101
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA N4P5X
UT WOS:001364179300006
PM 39588820
DA 2026-07-24
ER

PT J
AU Yasti, AÇ
   Karaca, T
   Kendirci, M
   Akgün, AE
   Sahiner, IT
   Akin, M
AF Yasti, Ahmet Cinar
   Karaca, Turgut
   Kendirci, Murat
   Akgun, Ali Emre
   Sahiner, Ibrahim Tayfun
   Akin, Merve
TI Comparison of the Efficiency of Epidermal Growth Factor and Negative
   Pressure Wound Therapy in Diabetic Foot Patients
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcers < Lower extremity wound; wound care; dressings;
   NPWT or TNP < Wound management; EGF; distalization of amputation
ID EGF; ENHANCE; ULCERS
AB Advanced modalities are used for wounds where conventional treatment is insufficient in diabetic foot patients. In this study, we investigated the effects of using Epidermal growth factor (EGF) and NPWTmodalities alone or in combination on the frequency and level of amputation. In the retrospective study, which included 286 patients in total, 76 patients were referred with the decision of amputation or amputation was planned during hospitalization. After the treatments, amputation and distalization of amputation were found 73.3% and 33.3% in the conventional treatment patients. While 86.4% amp and 18.2% amp distalization were found in negative pressure wound therapy (NPWT) only patients, this rate was 52.4% and 90.5% in EGF + NPWT patients, 50% and 83.3% in EGF only patients. While amp and distalization rates were found to be significantly better in those receiving only EGF or EGF + NPWT (P = .015, P = .017 respectively for amputation and P = .000 for distalization), no difference was found in those receiving EGF and EGF + NPWT. As a result of our study, although npwt contributed positively to the number and level of amputations compared to conventional treatment, a significant improvement was found in the number and level of amps when EGF was used alone or combined with NPWT. With this result, EGF was thought to be an important treatment modality that should be evaluated in diabetic foot ulcers (DFUs) without amputation decision.
C1 [Yasti, Ahmet Cinar] Hlth Sci Univ, Dept Gen Surg, Ankara, Turkey.
   [Kendirci, Murat; Sahiner, Ibrahim Tayfun] Hitit Univ, Dept Gen Surg, Corum, Turkey.
   [Akgun, Ali Emre; Akin, Merve] Ankara City Hosp, Gen Surg, Univ Mahallesi 1604,Cadde 9, TR-06800 Ankara, Cankaya, Turkey.
C3 University of Health Sciences Turkey; Hitit University; City Hospital
   Ankara; Presidency Turkey
RP Akin, M (通讯作者)，Ankara City Hosp, Gen Surg, Univ Mahallesi 1604,Cadde 9, TR-06800 Ankara, Cankaya, Turkey.
EM merveakin.2002@gmail.com
RI Akın, Merve/AAV-6282-2020; Kendirci, Murat/KIK-6978-2024; Sahiner,
   Ibrahim Tayfun/B-4864-2015; YASTI, AHMET CINAR/HPC-8757-2023
OI Akın, Merve/0000-0001-7224-4774; Akgün, Ali Emre/0000-0002-0389-4922;
   Sahiner, Ibrahim Tayfun/0000-0002-3921-7675; YASTI, AHMET
   CINAR/0000-0002-1281-3549
CR Armstrong DG, 2012, INT WOUND J, V9, P1, DOI 10.1111/j.1742-481X.2012.01015.x
   Boulton Andrew J M, 2008, Foot Ankle Surg, V14, P120, DOI 10.1016/j.fas.2008.05.004
   COHEN S, 1962, J BIOL CHEM, V237, P1555
   Dalla Paola L, 2013, INT WOUND J, V10, P25, DOI 10.1111/iwj.12174
   Faglia E, 1998, J DIABETES COMPLICAT, V12, P96, DOI 10.1016/S1056-8727(97)98004-1
   FALANGA V, 1992, J DERMATOL SURG ONC, V18, P604, DOI 10.1111/j.1524-4725.1992.tb03514.x
   Fernández-Montequín JI, 2009, INT WOUND J, V6, P67, DOI 10.1111/j.1742-481X.2008.00561.x
   FIMIANI V, 1973, B SOC ITAL BIOL SPER, V49, P933
   Frykberg Robert G, 2006, J Foot Ankle Surg, V45, pS1
   Game FL, 2012, DIABETES-METAB RES, V28, P119, DOI 10.1002/dmrr.2246
   Gupta S, 2012, INT WOUND J, V9, P8, DOI 10.1111/j.1742-481X.2012.01012.x
   Hardwicke J, 2008, SURG-J R COLL SURG E, V6, P172, DOI 10.1016/S1479-666X(08)80114-X
   Hong JP, 2006, ANN PLAS SURG, V56, P394, DOI 10.1097/01.sap.0000198731.12407.0c
   Liu ZM, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010318.pub3
   Ministry of Health, MAN CHRON WOUNDS 202
   Mohan VK, 2007, DIABETES RES CLIN PR, V78, P405, DOI 10.1016/j.diabres.2007.06.004
   Muthukumar T, 2014, COLLOID SURFACE B, V121, P178, DOI 10.1016/j.colsurfb.2014.06.018
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Park KH, 2018, DIABETES RES CLIN PR, V142, P335, DOI 10.1016/j.diabres.2018.06.002
   Robson MC, 1998, AM J SURG, V176, p80S, DOI 10.1016/S0002-9610(98)00186-X
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   Schultz GS, 2009, WOUND REPAIR REGEN, V17, P153, DOI 10.1111/j.1524-475X.2009.00466.x
   Sen P, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3165
   Sumpio BE, 2012, SCIENTIFICA, V2012, DOI 10.6064/2012/435487
   Tiaka Elisavet K, 2012, Perspect Vasc Surg Endovasc Ther, V24, P37, DOI 10.1177/1531003512442093
   Tsang MW, 2003, DIABETES CARE, V26, P1856, DOI 10.2337/diacare.26.6.1856
   Viswanathan V, 2020, INT J LOW EXTR WOUND, V19, P158, DOI 10.1177/1534734619892791
   Werner S, 2003, PHYSIOL REV, V83, P835, DOI 10.1152/physrev.2003.83.3.835
NR 28
TC 3
Z9 3
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 93
EP 102
DI 10.1177/15347346221123638
EA SEP 2022
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000851273600001
PM 36069057
DA 2026-07-24
ER

PT J
AU James, CV
   Patel, M
   Ellis, S
   Dudkiewicz, M
   Benvenisty, A
   Lantis, JC 
AF James, Crystal, V
   Patel, Munir
   Ellis, Scott
   Dudkiewicz, Michael
   Benvenisty, Alan
   Lantis, John C., II
TI The Use of Fetal Bovine Collagen on Chronic Wounds Increases Limb
   Salvage: A Single-center Retrospective Analysis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cellular- and tissue-based therapy; fetal bovine collagen; amputation;
   chronic wound; lower extremity wound; infection; limb salvage
ID DIABETIC FOOT
AB Objective. As part of a quality assurance project at a large tertiary care surgical program in New York City, the effect of debridement, negative pressure wound therapy, and cellular.- and tissue-based products (CTPs) on limb salvage was evaluated based on the following outcomes: freedom from amputation, wound closure, and freedom from readmission. Fetal bovine collagen was among the CTPs evaluated. Materials and Methods. The data used in this study were derived from a database of all patients who had undergone procedures involving placement of a dermal matrix at the center over a 2.5-year period (January 2016-June 2018). This retrospective analysis included 256 patients who underwent debridement and/or placement of a CTP as part of the treatment course for chronic wounds. Results. Of the 252 patients identified, 34 required either minor or major all-cause amputation from the initial wound intervention, whereas for 218 patients, there were no recorded amputations through the end of the study period after the initial wound intervention. When fetal bovine collagen was evaluated as an explanatory variable to the presence of future amputation, a statistically significant relationship between the variables was found. Conclusions. The results of the current data analysis indicate that a treatment algorithm that includes appropriate antibiotic therapy, tangential hydrosurgery, application of fetal bovine collagen, and a short course of negative pressure wound therapy may be a more favorable option to achieve limb salvage, freedom from readmission, and wound closure.
C1 [James, Crystal, V; Patel, Munir; Ellis, Scott] Mt Sinai Morningside West Hosp, Gen Surg, New York, NY 10025 USA.
   [Dudkiewicz, Michael; Benvenisty, Alan; Lantis, John C., II] Mt Sinai Morningside West Hosp, Icahn Sch Med Mt Sinai, Div Vasc Surg, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai
RP James, CV (通讯作者)，Mt Sinai Morningside West Hosp, 425 W 59th St,Floor 7, New York, NY 10025 USA.
EM Crystal.James2@mountsinai.org
RI Benvenisty, Alan/LTD-8563-2024
CR Driver VR, 2010, J VASC SURG, V52, p17S, DOI 10.1016/j.jvs.2010.06.003
   Driver VR, 2005, DIABETES CARE, V28, P248, DOI 10.2337/diacare.28.2.248
   Frykberg RG, 2015, ADV SKIN WOUND CARE, V28, P17, DOI 10.1097/01.ASW.0000456630.12766.e9
   Jeyaraman K, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-018-0327-2
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Santema TBK, 2016, WOUND REPAIR REGEN, V24, P737, DOI 10.1111/wrr.12434
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
NR 7
TC 1
Z9 1
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2022
VL 34
IS 3
BP 71
EP 74
DI 10.25270/wnds/2022.7174
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 0B2XV
UT WOS:000774504700001
PM 35273124
DA 2026-07-24
ER

PT J
AU Ren, B
   Jiang, XJ
   Chen, J
   Mo, JJ
AF Ren, Bei
   Jiang, XiaoJuan
   Chen, Jin
   Mo, JunJun
TI The efficacy of negative pressure wound therapy after
   hepatopancreatobiliary surgery: A systematic review and meta-analysis
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE Surgical site infection; Seroma; hematoma; Negative pressure wound
   therapy; Morbidity; Hospital re-admission
ID SURGICAL SITE INFECTION; CLOSED INCISION MANAGEMENT; RISK-FACTORS;
   HEPATOBILIARY; RATES
AB Objective: To evaluate the comparative influence of NPT and standard surgical dressing administration on incidence risk for surgical site infections, complications, and hospital readmission after hepatopancreatobiliary surgery.
   Methods: Five databases were systematically searched according to PRISMA guidelines. These databases included Web of Science, MEDLINE, CENTRAL, EMBASE, and Scopus for eligible studies published prior to March 2021. With eligible studies, we conducted a random-effects meta-analysis to evaluate comparative outcomes such as superficial surgical infection, deep surgical infection, seroma incidence, hematoma incidence, and hospital re-admission in patients receiving NPT or standard surgical dressings after hepatopancreatobiliary surgery.
   Results: The search strategy yielded 963 studies, with six studies meeting inclusion criteria. Odds of superficial surgical site infection ( OR: 1.58), deep surgical site infection (1.43), seroma complication (1.64), hematoma complication (0.40) were insignificantly different between patients receiving NPT and standard surgical dressing. The odds of hospital re-admission rate (2.37), however, were elevated in patients receiving standard surgical dressing relative to those receiving NPT.
   Conclusion: This meta-analysis shows that NPT usage slightly reduces risk of hospital readmission as compared to standard surgical dressing. We did not observe any significant effect of NPT on superficial, deep surgical infections, seroma, and haematoma outcomes following hepatopancreatobiliary surgery. These findings may aid clinicians in stratifying risk and selecting treatment strategy in patients undergoing hepatopancreatobiliary surgery.
C1 [Ren, Bei] First Peoples Hosp Wenling, Dept Wound Stoma Outpatient Care, Wenling, Zhejiang, Peoples R China.
   [Jiang, XiaoJuan] First Peoples Hosp Wenling, Dept Endocrinol, Wenling, Zhejiang, Peoples R China.
   [Chen, Jin] First Peoples Hosp Wenling, Outpatient Management Off, Wenling, Zhejiang, Peoples R China.
   [Mo, JunJun] First Peoples Hosp Wenling, Dept PICC Outpatient, Wenling, Zhejiang, Peoples R China.
RP Mo, JJ (通讯作者)，First Peoples Hosp Wenling, Dept PICC Outpatient, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Zhejiang, Peoples R China.
EM mojunjun1106@163.com
CR Andrianello S, 2021, SURGERY, V169, P1069, DOI 10.1016/j.surg.2020.10.029
   Arti H, 2016, PAK J MED SCI, V32, P65, DOI 10.12669/pjms.321.8568
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Bax L, 2007, BMC MED RES METHODOL, V7, DOI 10.1186/1471-2288-7-40
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
   Brace JA, 2007, J WOUND OSTOMY CONT, V34, P428, DOI 10.1097/01.WON.0000281661.77086.d1
   Brennfleck FW, 2021, INT WOUND J, V18, P17, DOI 10.1111/iwj.13511
   Ceppa EP, 2013, HPB, V15, P384, DOI 10.1111/j.1477-2574.2012.00604.x
   de Laat EHEW, 2011, ANN PLAS SURG, V67, P626, DOI 10.1097/SAP.0b013e31820b3ac1
   Duval S, 2000, BIOMETRICS, V56, P455, DOI 10.1111/j.0006-341X.2000.00455.x
   Ejaz A, 2017, J SURG RES, V217, P153, DOI 10.1016/j.jss.2017.05.018
   Gupta R, 2017, AM SURGEON, V83, P1166
   Harmon LJ, 2005, EVOLUTION, V59, P2705
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   Kuncewitch MP, 2019, AM SURGEON, V85, P1
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   Parikh P, 2010, HPB, V12, P488, DOI 10.1111/j.1477-2574.2010.00216.x
   Shen YJ, 2017, ENDOCRINE, V55, P75, DOI 10.1007/s12020-016-1014-6
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
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   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 32
TC 2
Z9 2
U1 0
U2 2
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD NOV-DEC
PY 2022
VL 38
IS 8
BP 2356
EP 2364
DI 10.12669/pjms.38.8.6601
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8T6SY
UT WOS:000929390200003
PM 36415224
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mizutani, Y
   Tamai, S
   Nakamura, T
   Hagiwara, Y
   Takita, T
   Kawamura, K
AF Mizutani, Yasushi
   Tamai, Susumu
   Nakamura, Toshifumi
   Hagiwara, Yusuke
   Takita, Takehiko
   Kawamura, Kenji
TI Conservative treatment of traumatic finger amputations using
   negative-pressure wound therapy
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Wound therapy; amputation; negative pressure
ID REPLANTATION
AB Replantation is widely regarded as the first choice of treatment for finger amputations. However, if the fingertip of a traumatic finger amputation is missing after an injury, the following procedures are often performed to reconstruct this portion: flap surgery, stump surgery, or conservative treatment, including occlusive dressings. To our knowledge, no existing English literature reports using negative-pressure wound therapy (NPWT) to treat traumatic finger amputations.
   We postulated that NPWT may be applied as a conservative treatment for traumatic finger amputations, promoting the growth of granulation tissue and achieving early epithelialization of the fingertips.
   Among the case series of five patients, we included six injured fingers comprising two index, two middle, and two ring fingers. The fingertip of each traumatic finger amputation was either missing or highly crushed, making replantation impossible. To preserve finger length with conservative treatment, we adapted an NPWT device for finger amputations. It took an average of 22.7 days for the fingertips to epithelialize. Immediately after epithelialization, there was a slight decrease in sensory perception; however, all patients showed good recovery of sensory perception after 3 months. Range of motion remained unrestricted, with no reduction in grip strength. Patients were highly satisfied with their fingertip appearance. The regenerated nail exhibited slight deformation and shortening. No complications were observed.
   Our novel study regarding this new conservative treatment and its outcomes revealed that healing was achieved in a relatively short period; therefore, NPWT may serve as a new conservative treatment option in the future.
C1 [Mizutani, Yasushi; Hagiwara, Yusuke; Takita, Takehiko] Takita Hosp, Orthoped Clin, Yamato Kohriyama Shi, Nara, Japan.
   [Tamai, Susumu; Nakamura, Toshifumi] Takita Hosp, Nara Hand Surg Inst, Nara, Japan.
   [Kawamura, Kenji] Nara Med Univ, Dept Orthoped Surg, 840 Shijyo Cho, Kashihara, Nara 6348522, Japan.
C3 Nara Medical University
RP Kawamura, K (通讯作者)，Nara Med Univ, Dept Orthoped Surg, 840 Shijyo Cho, Kashihara, Nara 6348522, Japan.
EM kkenji@naramed-u.ac.jp
RI Hagiwara, Yusuke/JBJ-0337-2023; Kawamura, Kenji/NFT-9921-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Hirase Y, 1997, PLAST RECONSTR SURG, V99, P774, DOI 10.1097/00006534-199703000-00026
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   Shine J, 2019, INT WOUND J, V16, P960, DOI 10.1111/iwj.13128
   TAMAI S, 1982, J HAND SURG-AM, V7, P549, DOI 10.1016/S0363-5023(82)80100-7
NR 10
TC 2
Z9 3
U1 0
U2 1
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PY 2023
VL 58
BP 115
EP 118
DI 10.2340/jphs.v58.18351
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HE4Z2
UT WOS:001157817200019
PM 37768149
OA gold
DA 2026-07-24
ER

PT J
AU Du, H
   Jiang, T
   Mao, RQ
   Yang, XF
   Chen, ZB
AF Du, Hai
   Jiang, Tao
   Mao, Renqun
   Yang, Xiaofan
   Chen, Zhenbing
TI The Role of Negative Pressure Therapy in Diabetic Foot Ulcer: A
   Meta-Analysis
SO JOURNAL OF DIABETES
LA English
DT Review
DE amputation; diabetic foot ulcer; meta-analysis; negative pressure wound
   therapy; wound healing rate
ID WOUND THERAPY; MULTICENTER
AB Diabetic foot ulcer (DFU) is a severe complication, often leading to amputation. Negative pressure wound therapy (NPWT) is an advanced treatment option requiring further consolidated evidence. This study evaluated the effectiveness and safety of NPWT versus conventional wound care for DFU, focusing on wound healing, amputation prevention, and adverse events (AEs). We systematically searched PubMed, Cochrane Library, Embase, and Web of Science for randomized controlled trials (RCTs) from inception until October 2025. Twenty-three RCTs involving 2086 participants were included. Two reviewers independently selected studies. Outcomes included wound healing rate, ulcer area reduction, amputation rate, and adverse events. Pooled odds ratios (OR) and standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random-effects models. NPWT significantly improved the wound healing rate (OR 4.48, 95% CI 2.58-7.77), led to a greater reduction in ulcer area (SMD 1.26, 95% CI 0.70-1.82), and substantially lowered amputation risk (OR 0.35, 95% CI 0.19-0.64) compared to conventional care. No significant difference was found in adverse events (OR 0.98, 95% CI 0.56-1.71). Subgroup analyses confirmed benefits across ages, follow-up durations, and control dressings. The healing benefit was most pronounced in less severe ulcers (Wagner grade < 2), while amputation protection was consistent across severities. NPWT is an effective and safe strategy for DFU, significantly accelerating wound healing and reducing amputation risk, supporting its integration as a cornerstone adjunctive therapy.
C1 [Du, Hai; Jiang, Tao; Yang, Xiaofan; Chen, Zhenbing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China.
   [Mao, Renqun] Shenzhen Nanshan Peoples Hosp, Dept Hand & Foot Surg, Shenzhen, Peoples R China.
   [Yang, Xiaofan] Huazhong Univ Sci & Technol, Hubei Key Lab Regenerat Med & Multidisciplinary Tr, Wuhan, Peoples R China.
   [Chen, Zhenbing] Hubei Prov Clin Res Ctr Chron Wound & Diabetic Foo, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Yang, XF; Chen, ZB (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China.; Yang, XF (通讯作者)，Huazhong Univ Sci & Technol, Hubei Key Lab Regenerat Med & Multidisciplinary Tr, Wuhan, Peoples R China.; Chen, ZB (通讯作者)，Hubei Prov Clin Res Ctr Chron Wound & Diabetic Foo, Wuhan, Peoples R China.
EM 2017xh0119@hust.edu.cn; zbchen@hust.edu.cn
RI du, hai/MVV-7719-2025
OI Du, Hai/0009-0005-6959-8770
FU Medical Science and Technology Research Foundation of Guangdong Province
   [B2024010]; the Health Science and Technology Project of Hubei Province
   [WJ2025Z007]; National Natural Science Foundation of China [82472566,
   82370838]; the Key Research and Development Program of Hubei Province
   [2024BCB039]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 82472566, 82370838), the Health Science and
   Technology Project of Hubei Province (grant number WJ2025Z007), the Key
   Research and Development Program of Hubei Province (grant number
   2024BCB039), and the Medical Science and Technology Research Foundation
   of Guangdong Province (grant number B2024010).
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NR 52
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD APR 8
PY 2026
VL 18
IS 4
AR e70226
DI 10.1111/1753-0407.70226
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GG4JT
UT WOS:001735797500001
PM 41952430
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Freire, M
   Job, C
   Hassanpour, I
   Benito, J
   Pang, DSJ
   Paquet, M
   Theoret, CL
AF Freire, Mila
   Job, Chloe
   Hassanpour, Ida
   Benito, Javier
   Pang, Daniel S. J.
   Paquet, Marilene
   Theoret, Christine L.
TI A disposable, canister-free negative-pressure wound therapy device
   proves feasible, but of inferior efficacy to conventional therapies for
   treating cutaneous wounds in dogs
SO AMERICAN JOURNAL OF VETERINARY RESEARCH
LA English
DT Article
AB OBJECTIVE To assess the feasibility of a canister -free negative -pressure wound therapy (NPWT) device (PICOTM 1.6, Smith & Nephew Medical Ltd) and evaluate its effect on early phases of wound healing in canine experimental cutaneous wounds. ANIMALS 5 adult spayed female research Beagles. PROCEDURES In a pilot experimental study, 1 full -thickness 2 -cm X 2 -cm cutaneous wound was surgically created on each hemi - thorax in each dog. Wounds were treated with either NPWT or a conventional wound dressing for 14 days. Bandage changes and wound evaluations were done at 7 time points. First macroscopic appearance of granulation tissue, smoothness of granulation tissue, and percentages of wound contraction and epithelialization were compared between treatments. Wounds were sampled at 3 time points for histopathologic analyses and semiquantitative scoring. RESULTS NPWT dressings were well tolerated by all dogs. Complete seal of the dressing required the application of adhesive spray, and maintenance of the vacuum lessened over time. Self-limiting skin irritations appeared in all dogs and hampered the attainment of negative pressure. Granulation tissue developed faster and was more abundant in con - trol wounds. Wound contraction, epithelialization, and fibroblast proliferation were greater in control wounds at the end of the study. CLINICAL RELEVANCE This canister -free NPWT device is feasible but problematic in maintaining a vacuum, requiring frequent revisions of the dressing. Further studies are necessary to evaluate the effect of this device on early phases of wound healing. Its benefits in wound healing remain unknown.
C1 [Freire, Mila; Job, Chloe; Hassanpour, Ida; Benito, Javier] Univ Montreal, Fac Vet Med, Dept Clin Sci, St Hyacinthe, PQ, Canada.
   [Pang, Daniel S. J.] Univ Calgary, Fac Vet Med, Calgary, AB, Canada.
   [Paquet, Marilene] Univ Montreal, Fac Vet Med, Dept Pathol & Microbiol, St Hyacinthe, PQ, Canada.
   [Theoret, Christine L.] Univ Montreal, Fac Vet Med, Dept Biomed Sci, St Hyacinthe, PQ, Canada.
C3 Universite de Montreal; University of Calgary; Universite de Montreal;
   Universite de Montreal
RP Freire, M (通讯作者)，Univ Montreal, Fac Vet Med, Dept Clin Sci, St Hyacinthe, PQ, Canada.
EM m.freire.gonzalez@umontreal.ca
RI ; Paquet, Marilène/L-3414-2019; Benito de la Víbora,
   Javier/AEX-9842-2022; Pang, Daniel/B-8291-2013; /C-7320-2015
OI Freire, Mila/0000-0002-0410-8321; Paquet, Marilène/0000-0002-3562-4636;
   Benito de la Víbora, Javier/0000-0002-8174-1278; Job,
   chloé/0000-0001-8689-0259; 
FU Zoetis Clinical Research Funds of the Faculty of Veterinary Medicine of
   the Universite de Montreal
FX This study was supported by the Zoetis Clinical Research Funds of the
   Faculty of Veterinary Medicine of the Universite de Montreal and an
   in-kind donation from Smith & Nephew Canada. The authors declare there
   were no conflicts of interest and the funders had no role in the
   conception or execution of the study.
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NR 22
TC 0
Z9 1
U1 0
U2 2
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0002-9645
EI 1943-5681
J9 AM J VET RES
JI Am. J. Vet. Res.
PD OCT
PY 2022
VL 83
IS 10
AR 0029
DI 10.2460/ajvr.22.02.0029
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA VN9AS
UT WOS:001248227800019
PM 35973001
OA gold
DA 2026-07-24
ER

PT J
AU Jiang, Y
   Li, XG
   Zhao, HJ
   Meng, XY
   Nie, XG
   Wang, GD
   Li, J
AF Jiang, Yang
   Li, Xiugeng
   Zhao, Haijian
   Meng, Xiangyan
   Nie, Xingguo
   Wang, Guodong
   Li, Jian
TI An explainable machine learning model to predict biofilm formation in a
   wound-care population with a high burden of chronic wounds
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Chronic wounds; Bacterial biofilm formation; Explainable machine
   learning; Random forest
AB Purpose To develop and validate an explainable machine learning model for predicting bacterial biofilm formation in clinical wounds. Methods We conducted a multicenter retrospective cohort study at two tertiary hospitals in China. From 550 eligible patients, a training cohort (n = 385) and a testing cohort (n = 165) were created, with an independent cohort (n = 300) for external validation. Predictors available at the index encounter were prespecified and imputed. Feature selection combined Boruta and LASSO, yielding six variables: Debridement performed, Chronic wound,Thermal therapy, Negative pressure wound therapy, Diabetes mellitus, and Silver dressing used. Eight algorithms were tuned with stratified fivefold cross-validation. Discrimination, calibration, and decision curve analysis were assessed. SHAP was used for model interpretation. Results Random forest achieved the best performance with AUC 0.929 in training, 0.861 in testing, and 0.837 in external validation, with good calibration and consistent net benefit on decision curves. SHAP ranked Debridement performed as most influential. Debridement performed, Thermal therapy, Negative pressure wound therapy, and Silver dressing used showed predominantly negative SHAP values, indicating inverse associations with biofilm formation. Chronic wound and Diabetes mellitus showed positive SHAP values. Conclusion An interpretable random forest model with six routinely collected predictors accurately estimated biofilm formation in clinical wounds.The model's strong external performance and biological plausibility suggest potential utility for early risk stratification and tailored wound management, warranting prospective validation in diverse clinical environments.
C1 [Jiang, Yang; Li, Jian] Henan Med Univ, Affiliated Hosp 1, Burn Plast Surg & Med Aesthet Dept, 88 Jiankang Rd, Weihui City 453100, Henan, Peoples R China.
   [Li, Xiugeng] Henan Med Univ, Affiliated Hosp 1, Dept Colorectal & Proctol, Weihui City, Henan, Peoples R China.
   [Zhao, Haijian; Nie, Xingguo] Henan Med Univ, Affiliated Hosp 1, Dept Microsurg Hands & Feet, Weihui City, Henan, Peoples R China.
   [Meng, Xiangyan] Henan Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Weihui City, Henan, Peoples R China.
   [Wang, Guodong] Xinxiang Med Univ, Affiliated Hosp 1, Dept Emergency Med, Weihui City, Henan Province, Peoples R China.
C3 Henan Medical University
RP Li, J (通讯作者)，Henan Med Univ, Affiliated Hosp 1, Burn Plast Surg & Med Aesthet Dept, 88 Jiankang Rd, Weihui City 453100, Henan, Peoples R China.
EM FAHOHNMUJY@163.com; lxg310@126.com; zhaohaijianyu@126.com;
   mengxiangyan9992006@126.com; nxgnxg@163.com; wangjuanxy@126.com;
   LJHNMU@163.com
FU Jingding Medical Tech
FX This study was generously supported by Jingding Medical Tech, to whom we
   extend our sincere gratitude. We especially thank them for providing
   authorization and technical support for the JD_DCPM software. The team
   at Jingding Medical Tech offered invaluable assistance in data
   processing.
CR Bortesi JPT, 2024, J MED INTERNET RES, V26, DOI 10.2196/52880
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   Zheng Y, 2025, ACTA BIOMATER, V193, P545, DOI 10.1016/j.actbio.2024.12.042
NR 24
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD MAR 28
PY 2026
VL 31
IS 1
AR 673
DI 10.1186/s40001-026-04300-4
EA MAR 2026
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HN6DX
UT WOS:001758320900001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Vintila, D
   Tanevski, A
   Chiriac, S
   Stefanescu, G
   Abdulan, IM
   Balan, GG
   Veliceasa, B
   Badulescu, OV
   Ghiga, G
   Fatu, AM
   Georgescu, A
   Vascu, MB
   Vasilescu, AM
AF Ciuntu, Bogdan Mihnea
   Vintila, Dan
   Tanevski, Adelina
   Chiriac, Stefan
   Stefanescu, Gabriela
   Abdulan, Irina Mihaela
   Balan, Gheorghe G.
   Veliceasa, Bogdan
   Badulescu, Oana Viola
   Ghiga, Gabriela
   Fatu, Ana Maria
   Georgescu, Andrei
   Vascu, Mihai Bogdan
   Vasilescu, Alin Mihai
TI Severe Acute Pancreatitis Treated with Negative Pressure Wound Therapy
   System: Influence of Laboratory Markers
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy system; open abdomen; severe acute
   pancreatitis; abdominal compartment syndrome
ID ABDOMINAL COMPARTMENT SYNDROME; FLUID RESUSCITATION; INTRAABDOMINAL
   HYPERTENSION; OPEN ABDOMEN; OUTCOMES
AB (1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications and improve patient outcomes. Negative pressure therapy (NPT) has emerged as a viable therapeutic option for temporary closure of the abdomen, offering several benefits over traditional methods.(2) Methods: We included 15 patients with pancreatitis who were hospitalized in the I-II Surgery Clinic of the Emergency County Hospital "St. Spiridon" from Iasi, Romania, between 2011-2018 and received NPT. (3) Results: Preoperatively, the mean IAP level was 28.62 mmHg, decreasing significantly postoperatively to 21.31 mmHg. The mean level of the highest IAP value recorded in pancreatitis patients treated with VAC did not differ significantly by lethality (30.31 vs. 28.50; p = 0.810). In vacuum-treated pancreatitis patients with a IAP level > 12, the probability of survival dropped below 50% during the first 7 days of stay in the ICU, so that after 20 days the probability of survival was approximately 20%. IAP enters the determinism of surgery with a sensitivity of 92.3% and a specificity of 99%, the cut-off value of IAP being 15 mmHg.(4) Conclusions: The timing of surgical decompression in abdominal compartment syndrome is very important. Consequently, it is vital to identify a parameter, easy to measure, within the reach of any clinician, so that the indication for surgical intervention can be made judiciously and without delay.
C1 [Ciuntu, Bogdan Mihnea; Vintila, Dan; Tanevski, Adelina; Vasilescu, Alin Mihai] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Iasi 700115, Romania.
   [Chiriac, Stefan; Stefanescu, Gabriela; Balan, Gheorghe G.] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Veliceasa, Bogdan] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Traumatol & Orthopaed, Iasi 700115, Romania.
   [Badulescu, Oana Viola] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Haematholohy, Iasi 700115, Romania.
   [Ghiga, Gabriela] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Mother & Child Med, Iasi 700115, Romania.
   [Fatu, Ana Maria] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Implantol Removable Denture Technol, Discipline Ergon, Iasi 700115, Romania.
   [Georgescu, Andrei; Vascu, Mihai Bogdan] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Odontol Periodontol & Fixed Prosthesi, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy
RP Stefanescu, G (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.; Abdulan, IM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; dan.vintila@umfiasi.ro;
   papancea.adelina@umfiasi.ro; stefanchiriac@yahoo.com;
   gabriela.stefanescu@gmail.com; irina.abdulan@yahoo.com;
   gheorghe-g-balan@umfiasi.ro; bogdan.veliceasa@umfiasi.ro;
   viola.badulescu@umfiasi.ro; gabriela.ghiga@umfiasi.ro;
   ana.fatu@umfiasi.ro; andrei.georgescu@umfiasi.ro;
   mihai.vascu@umfiasi.ro; alin.vasilescu@umfiasi.ro
RI Fatu, ANA/MTE-5072-2025; Tanevski, Adelina/LUZ-8095-2024; Ciuntu,
   Bogdan/MTF-9477-2025; Veliceasa, Bogdan/AFV-2751-2022; Abdulan,
   Irina/AAA-3089-2020; Balan, Gheorghe/OZF-7157-2025; Vascu, Mihai
   Bogdan/MTE-8733-2025; Georgescu, Andrei/KFB-5405-2024; Chiriac,
   Stefan/MTF-7600-2025; Vasilescu, Alin Mihai/HPE-4046-2023
OI Veliceasa, Bogdan/0000-0002-9941-3424; Stefanescu,
   Gabriela/0000-0002-1394-8648; Vascu, Mihai Bogdan/0009-0009-2470-4735;
   Georgescu, Andrei/0000-0001-7407-844X; Chiriac,
   Stefan/0000-0003-2497-9236; Vasilescu, Alin Mihai/0000-0002-9865-5114
CR Aggarwal A, 2014, WORLD J GASTROENTERO, V20, P18092, DOI 10.3748/wjg.v20.i48.18092
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NR 30
TC 0
Z9 0
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 28
PY 2023
VL 12
IS 11
AR 3721
DI 10.3390/jcm12113721
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I9GK3
UT WOS:001005789500001
PM 37297916
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wiegand, C
   Springer, S
   Abel, M
   Wesarg, F
   Ruth, P
   Hipler, UC
AF Wiegand, Cornelia
   Springer, Steffen
   Abel, Martin
   Wesarg, Falko
   Ruth, Peter
   Hipler, Uta-Christina
TI Application of a drainage film reduces fibroblast ingrowth into
   large-pored polyurethane foam during negative-pressure wound therapy in
   an in vitro model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; GAUZE; TRANSDUCTION; EXPRESSION; DEVICE; SKIN
AB Negative-pressure wound therapy (NPWT) is an advantageous treatment option in wound management to promote healing and reduce the risk of complications. NPWT is mainly carried out using open-cell polyurethane (PU) foams that stimulate granulation tissue formation. However, growth of wound bed tissue into foam material, leading to disruption of newly formed tissue upon dressing removal, has been observed. Consequently, it would be of clinical interest to preserve the positive effects of open-cell PU foams while avoiding cellular ingrowth. The study presented analyzed effects of NPWT using large-pored PU foam, fine-pored PU foam, and the combination of large-pored foam with drainage film on human dermal fibroblasts grown in a collagen matrix. The results showed no difference between the dressings in stimulating cellular migration during NPWT. However, when NPWT was applied using a large-pored PU foam, the fibroblasts continued to migrate into the dressing. This led to significant breaches in the cell layers upon removal of the samples after vacuum treatment. In contrast, cell migration stopped at the collagen matrix edge when fine-pored PU foam was used, as well as with the combination of PU foam and drainage film. In conclusion, placing a drainage film between collagen matrix and the large-pored PU foam dressing reduced the ingrowth of cells into the foam significantly. Moreover, positive effects on cellular migration were not affected, and the effect of the foam on tissue surface roughness in vitro was also reduced.
C1 [Wiegand, Cornelia; Springer, Steffen; Hipler, Uta-Christina] Univ Med Ctr Jena, Dept Dermatol, D-07740 Jena, Germany.
   [Wesarg, Falko] Univ Jena, Inst Mat Sci & Technol, Jena, Germany.
   [Abel, Martin; Ruth, Peter] Lohmann & Rauscher GmbH & Co KG, Rengsdorf, Germany.
C3 Friedrich Schiller University of Jena; Lohmann & Rauscher (L&R)
RP Wiegand, C (通讯作者)，Univ Med Ctr Jena, Dept Dermatol, Erfurter Str 35, D-07740 Jena, Germany.
EM c.wiegand@med.uni-jena.de
RI ; Abel, Martin/JFS-2478-2023
OI Springer, Steffen/0000-0002-9224-2925; Abel, Martin/0000-0002-0683-0553
FU Lohmann & Rauscher GmbH & Co KG, Rengsdorf, Germany; Lohmann & Rauscher
   GmbH Co. KG Germany
FX This work was funded by Lohmann & Rauscher GmbH & Co KG, Rengsdorf,
   Germany.The authors would like to disclose that the authors M. A. and P.
   R. are employees of Lohmann & Rauscher GmbH & Co. KG Germany and that
   the authors C. W. and U.-C. H. received travel grants from Lohmann &
   Rauscher GmbH & Co. KG Germany to participate at wound healing
   conferences.
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NR 25
TC 4
Z9 5
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 697
EP 703
DI 10.1111/wrr.12073
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300008
PM 23937617
DA 2026-07-24
ER

PT J
AU Gao, X
   Yin, HL
   Sun, JX
AF Gao, Xu
   Yin, Hailei
   Sun, Jixia
TI Preoperative irrigation and vacuum sealing drainage with
   antibiotic-containing drainage fluid of foot and ankle wounds improves
   outcome of reconstructive skin flap surgery
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Flap reconstruction; Bacterial infection; Inflammatory response
ID ASSISTED CLOSURE; THERAPY; BACTERIAL; INFECTIONS; PREVENTION; MANAGEMENT
AB Objectives By observing the infection and soft tissue defect on the wound surface of the foot and ankle, this paper attempts to explore the effect of preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid (abPI-VSD) on the bacterial quantity and the local inflammatory response at the flap, and further to provide a basis for applying this technique before a reconstructive skin flap surgery of foot and ankle wounds. Methods Seventy-five patients were randomly divided into two groups, and all surgeries were done by one physician. The flap reconstructions were done to 31 cases with the abPI-VSD being used (group A); the flap reconstructions were done to the rest 44 cases after wound cleaning using antibiotic irrigation solution without the use of the abPI-VSD (group B). Quantitative bacteriology was made to group A before and after the use of abPI-VSD; quantitative bacteriology was made to group B before and after wound cleaning. Then, the reconstructive skin flap surgery was done. After the surgeries, the time of local inflammatory response at the flap in both groups were recorded. The measured bacterial quantity was evaluated in logarithm and by t test. Results The bacterial quantity was 3.2 +/- 1.9 x 10(7) cfu/g in group A before the use of abPI-VSD and 2.3 +/- 2.0 x 10(7) in group B (P > 0.05) before debridement. The bacterial quantity was 1.2 +/- 2.0 x 10(4) cfu/g in group A after abPI-VSD and was 2.9 +/- 4.0 x 10(6) in group B after wound cleaning (P < 0.05). The time of postoperative inflammatory response in the flap was 8 +/- 2.5 days in group A and 13 +/- 3.4 days in group B (P < 0.05). Conclusions abPI-VSD can distinctly reduce the bacterial quantity on the surface of the wound, provide a good condition of tissue bed for the flap reconstruction, and effectively control the local inflammatory response at the flap and hence improve the survival quality of the flap.
C1 [Gao, Xu] Qingdao Univ, Dept Orthoped, Qingdao 266071, Shandong, Peoples R China.
   [Yin, Hailei] 971 Hosp People Liberat Army, Dept Orthoped, 22 Min Jiang Rd, Qingdao 266071, Shandong, Peoples R China.
   [Sun, Jixia] Qingdao Cent Hosp, Dept Foot & Hand Trauma Surg, Qingdao 266071, Shandong, Peoples R China.
C3 Qingdao University
RP Yin, HL (通讯作者)，971 Hosp People Liberat Army, Dept Orthoped, 22 Min Jiang Rd, Qingdao 266071, Shandong, Peoples R China.
EM gukedor@163.com
RI yin, hailei/LGZ-3641-2024
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NR 35
TC 8
Z9 12
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD NOV 20
PY 2019
VL 14
IS 1
AR 374
DI 10.1186/s13018-019-1418-0
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA JQ0OZ
UT WOS:000498655800001
PM 31747959
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Guo, JL
   Feng, W
   Song, BJ
   Zhu, DJ
   Wen, YW
   Wang, Q
AF Guo, Jiale
   Feng, Wei
   Song, Baojian
   Zhu, Danjiang
   Wen, Yuwei
   Wang, Qiang
TI Clinical characteristics and risk factors for poor prognosis in children
   with complicated acute hematogenous osteomyelitis treated with vaccum
   sealing drainage
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Acute hematogenous osteomyelitis; Risk factors; Prognosis; Children
ID PEDIATRIC OSTEOMYELITIS; BONE; PROCALCITONIN
AB BackgroundThis study aims to analyze the clinical characteristics of children with complicated acute hematogenous osteomyelitis treated with vacuum sealing drainage (VSD) in our institution, and to explore the risk factors for poor prognosis.MethodsA retrospective analysis was performed on the medical records of patients diagnosed with acute hematogenous Osteomyelitis from December 2015 to December 2022. The demographic profiles, treatment procedures, examination results, and follow-up information of the patients were meticulously recorded. Patients were categorized into two groups based on the occurrence of treatment failure, deformity, limb length discrepancy, growth arrest, osteonecrosis, chronic osteomyelitis, pathological fracture, chondrolysis, and recurrence: good prognosis group and poor prognosis group. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors associated with adverse prognosis. The performance of the regression model was assessed using the area under the receiver operating characteristic (ROC) curve.ResultsA total of 150 patients who met the inclusion criteria were followed up for an average of 3.4 years (range: 1.0-7.0 years). There were 31 patients (21%) in the poor prognosis group. In all cases, after 7 days of continuous saline irrigation and 2 surgical debridement, 75% of the infections were completely controlled, and the local abscess disappeared in 86% of the patients. By regression analysis, leukocyte admission (adjusted odds ratio (aOR) 1.2; 95% confidence interval (CI) [1.0-1.4]; P = 0.04), first postoperative C-reactive protein level (aOR 1.04; 95% (CI), [1.0-1.07], P = 0.034), time to diagnosis of osteomyelitis (aOR 1.3; 95% (CI), [1.1-1.6], P = 0.012), and days of fever with antibiotics (aOR 1.5; 95% (CI), [1.1-2.2], P = 0.024) were independent risk factors for poor outcomes. The four variables combined to construct an efficient prediction model, with an area under the curve (AUC) of 0.85.ConclusionThe innovative application of vacuum sealing drainage technology in the management of complicated patients with substantially localized abscesses achieved significant efficacy, while one-third of children still had unfavorable outcomes. High-risk groups with recurrence and sequelae necessitate regular follow-up and even long-term orthopedic intervention.
C1 [Guo, Jiale; Feng, Wei; Song, Baojian; Zhu, Danjiang; Wen, Yuwei; Wang, Qiang] Capital Med Univ, Beijing Childrens Hosp, Dept Orthopaed, Nanlishi Rd 56, Beijing 100045, Peoples R China.
   [Guo, Jiale; Feng, Wei; Song, Baojian; Zhu, Danjiang; Wen, Yuwei; Wang, Qiang] Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China.
C3 Capital Medical University
RP Wang, Q (通讯作者)，Capital Med Univ, Beijing Childrens Hosp, Dept Orthopaed, Nanlishi Rd 56, Beijing 100045, Peoples R China.; Wang, Q (通讯作者)，Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China.
EM wangqiangmd@aliyun.com
FU Natural Science Foundation of Beijing Municipality
FX Firstly, I would like to express my gratitude to Professor Qiang Wang,
   my esteemed teacher, for his invaluable feedback on revisions and
   technical guidance. Wei Feng, offering formal analysis and associated
   corrections. Baojian Song, writing assistance, or proofreading the
   article. Danjiang Zhu, providing spiritual motivation and empirical
   evidence support. Yuwei Wen, assisting with ideas, language creating
   illustrations, and generating tables. The study was conducted without
   any financial support. Thank you immensely for your invaluable
   assistance.
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NR 31
TC 2
Z9 2
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 14
PY 2025
VL 26
IS 1
AR 963
DI 10.1186/s12891-025-09094-w
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 8QI2R
UT WOS:001594798000003
PM 41088318
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ren, GH
   Li, RG
   Jiang, GY
   Chen, CJ
   Bao, ZG
AF Ren Gao-hong
   Li Run-guang
   Jiang Gui-yong
   Chen Chao-jie
   Bao Zhi-gang
TI A solution to the vessel shortage during free vascularized fibular
   grafting for reconstructing infected bone defects of the femur: Bridging
   with vein transplantation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Bone defect repair; Infected femur bone defect; Orthopedic infection;
   Vascularized fibular graft; Vessel transplantation
ID DONOR-SITE MORBIDITY; FREE-FLAP TRANSPLANTATION; VACUUM SEALING
   DRAINAGE; PRESSURE WOUND THERAPY; OSTEOMYELITIS; TRANSPORT;
   METAANALYSIS; EXTREMITIES; KNEE
AB Purpose: The present study aimed to evaluate the feasibility and clinical efficacy of bridging vein transplantation to deal with the vessel shortage during free vascularized fibular grafting for reconstructing infected bone defects of the femur.
   Methods: Twelve patients (aged 15-58 years) with infected bone defects of the femur (between 6.0 and 18.0 cm) were recruited in this study. Vacuum sealing drainage were applied after extensive debridement of the infected bone defects and irrigated with 0.9% sodium chloride solution for 1-2 weeks. After the drainage was clear and the focal infections were controlled, the free vascularized fibula was harvested for reconstructing the femoral bone defects. The vascularized fibula was grafted and fixated appropriately at the recipient site. The autogenous great saphenous vein was harvested, one end was anastomosed and bridged the vascular pedicles of the fibular grafts, and the other end anastomosed the artery and/ or the vein in the recipient healthy site.
   Results: Mean length of vein transplantationwith vascularized fibular graft was 10.2 cm (range 7-15 cm). All patients had good radiological healing without recorded nonunion or malunion. No patient developed deep infection or implant failure. Primary bone healing was achieved in 10 patients; however, 2 grafted fibular formed pseudarthrosis with the recipient femoral and then healed after a secondary surgery. One patient suffered from graft stress fracture after bone healing and healed after external fixation. After the mean follow-up of 30 months (9-72 months), according to the Enneking scoring system, clinical outcomes were excellent in 7 patients, good in 4 and fair in one. The functional recovery rate of the lesion limb was 89.4%.
   Conclusions: Free vascularized fibular graft with vein transplantation bridged vascular pedicle can effectively repair the infected bone, improve blood supply to the bone defect site, and help control infection. It is a feasible and effective treatment for infected bone defects of the femur with poor soft tissue conditions, or blood supply vessel shortage. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ren Gao-hong; Li Run-guang; Jiang Gui-yong; Chen Chao-jie; Bao Zhi-gang] Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Ren, GH (通讯作者)，Southern Med Univ, Dept Orthopaed & Traumatol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
EM doctor020@163.com
RI ; Chen, Chaojie/PCQ-6635-2025; Jiang, Guiyong/LRB-3721-2024
OI Gaohong, Ren/0000-0002-4941-6723; Runguang, Li/0000-0002-4703-7180; 
FU Natural Science Foundation of Guangdong Province [S2012010009434];
   "Special Project on the Integration of Industry, Education and Research
   of Guangdong Province" in China [2012B091100462]
FX This work was supported by the "Natural Science Foundation of Guangdong
   Province" (Approval number S2012010009434) and "Special Project on the
   Integration of Industry, Education and Research of Guangdong Province"
   (Approval number 2012B091100462) in China.
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NR 40
TC 13
Z9 20
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2017
VL 48
IS 2
BP 486
EP 494
DI 10.1016/j.injury.2016.10.027
PG 9
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA EO8BO
UT WOS:000396914100044
PM 27876350
DA 2026-07-24
ER

PT J
AU Sziklavari, Z
   Hammoudeh, S
   Petrone, AM
   Stange, S
   Orban, K
   Fekete, JT
   Hofmann, HS
AF Sziklavari, Zsolt
   Hammoudeh, Sameer
   Petrone, Ana-Maria
   Stange, Sebastian
   Orban, Karoly
   Fekete, Janos Tibor
   Hofmann, Hans-Stefan
TI Outcomes of Vacuum-Assisted Closure in Patients with Empyema Thoracis: A
   10-Year Experience
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID PARAPNEUMONIC EMPYEMA; PLEURAL EMPYEMA; MANAGEMENT; SOCIETY
AB BACKGROUND Video-assisted thoracic surgery is currently the recommended treatment for patients with empyema thoracis. However, open-window thoracostomy (OWT) is not uncommon and is performed as a last resort in patients who are in poor general condition or with complicated empyema. Although several professional associations have recommended vacuum-assisted closure (VAC) as an adjunct to standard treatment, exact data regarding the clinical role of intrathoracic VAC are not available. The primary objective of this study was to determine the safety and efficacy of intrathoracic VAC in debilitated patients and to compare the results with those of previous OWT studies. METHODS We investigated 127 patients with a poor performance status who initially received inpatient intrathoracic VAC for stage II/III empyema thoracis between January 2010 and December 2020. RESULTS The median duration of VAC was 15 days, and the median length of stay was 18 days. Two patients had complications, and the in-hospital mortality rate was 11.8% (15 of 127). Among the 112 surviving patients, 25 (22.3%) were discharged with OWT and 87 (77.7%) were discharged with a closed chest. Empyema recurred in 5 patients. Ultimately, we recorded an absolute success rate of 64.6% (82 of 127). CONCLUSIONS Intrathoracic VAC appears to be safer and associated with less morbidity and mortality than OWT in debilitated patients with empyema. Our results revealed a reduced hospital length of stay and an improved success rate. The results of this work should contribute to improving treatment success in pleural empyema patients.
C1 [Sziklavari, Zsolt; Hammoudeh, Sameer; Petrone, Ana-Maria; Stange, Sebastian; Orban, Karoly] REGIOMED Klinikum, Dept Thorac Surg, Coburg, Germany.
   [Fekete, Janos Tibor] Semmelweis Univ, Dept Bioinformat, Budapest, Hungary.
   [Hofmann, Hans-Stefan] Univ Med Ctr Regensburg, Dept Thorac Surg, Regensburg, Germany.
C3 Semmelweis University; University of Regensburg
RP Sziklavari, Z (通讯作者)，REGIOMED Klinikum Coburg, Dept Thorac Surg, Ketschendorfer Str 33, D-96450 Coburg, Germany.
EM sziklavari_zsolt@yahoo.com
RI Fekete, János Tibor/J-4505-2018; Sziklavari, Zsolt/AGI-2440-2022
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NR 24
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2025
VL 119
IS 6
BP 1206
EP 1212
DI 10.1016/j.athoracsur.2024.08.003
EA JAN 2025
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 3MG9W
UT WOS:001503726000008
PM 39178929
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Vasiluta, C
   Negru, R
   Hultoana, R
   Ciuntu, R
   Georgescu, SO
   Sirbu, PD
   Azoicai, D
AF Ciuntu, Bogdan Mihnea
   Vasiluta, Ciprian
   Negru, Robert
   Hultoana, Roxana
   Ciuntu, Roxana
   Georgescu, Stefan Octavian
   Sirbu, Paul Dan
   Azoicai, Doina
TI Negative Pressure Therapy in the Surgical Treatment of Diabetic Foot
SO REVISTA DE CHIMIE
LA English
DT Article
DE negative pressure; diabetic foot; wound volume
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; MELLITUS
AB The study aims to assess the significance of negative pressure therapy in the treatment of diabetic foot. The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 37 patients with diabetic foot were monitored their clinical course between September 2014 - Apri12017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) -Hartman) in order to apply negative pressure to the wound, while complying with specified settings (negative pressure, time of use of a kit) in accordance with patients' outcome. There were monitored changes in wound size (planimetric and volumetric measurement), their bacterial load and duration of treatment Healing was obtained in all cases, to an average hospital stay of 27.3 days and 8 days of therapy application. The negative result of microbial cultures was obtained after an average of 6.45 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. Skin grafts were necessary to close the defect in 4 cases. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing. ln patients with diabetic foot who were required surgical intervention, the use of negative pressure therapy yielded a significant benefit in the preservation of the affected limb, after minimal excision. The results we obtained throughout our experience recommend use of NPTW technique as indication for abdominal wall surgery in closing abdominal wall defects, compartment syndrome and surgical site infection after prosthetic mesh.
C1 [Ciuntu, Bogdan Mihnea; Vasiluta, Ciprian; Hultoana, Roxana; Georgescu, Stefan Octavian] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.
   [Negru, Robert] Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.
   [Ciuntu, Roxana] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Ophtalmol, 16 Univ Str, Iasi 700115, Romania.
   [Sirbu, Paul Dan] Grigore T Popa Univ Med & Pharm Iasi, Fac Gen Med, Dept Orthoped & Traumatol, Surg Sci 2, 16 Univ Str, Iasi 700115, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Prevent Med & Inderdisciplinar, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.; Sirbu, PD (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Gen Med, Dept Orthoped & Traumatol, Surg Sci 2, 16 Univ Str, Iasi 700115, Romania.
EM bogdanmciuntu@yahoo.com; pdsirbu@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; Negru, Robert/HDM-9550-2022; AZOICAI,
   DOINA/HDO-6161-2022; Sirbu, Paul-Dan/KBP-9023-2024
OI AZOICAI, DOINA/0000-0003-0423-4085; Sirbu, Paul-Dan/0000-0003-2806-0649
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NR 17
TC 11
Z9 11
U1 0
U2 15
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD JUL
PY 2017
VL 68
IS 7
BP 1648
EP 1651
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FF7ZJ
UT WOS:000409234600051
DA 2026-07-24
ER

PT J
AU Quyn, AJ
   Johnston, C
   Hall, D
   Chambers, A
   Arapova, N
   Ogston, S
   Amin, AI
AF Quyn, A. J.
   Johnston, C.
   Hall, D.
   Chambers, A.
   Arapova, N.
   Ogston, S.
   Amin, A. I.
TI The open abdomen and temporary abdominal closure systems - historical
   evolution and systematic review
SO COLORECTAL DISEASE
LA English
DT Review
DE Open abdomen; laparostomy; historical evolution; systematic review
ID VACUUM-ASSISTED CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH; SEVERE
   INTRAABDOMINAL INFECTION; VASCULAR CATASTROPHES ABSENCE; TOPICAL
   NEGATIVE-PRESSURE; DAMAGE CONTROL LAPAROTOMY; CONTROL OPEN CELIOTOMIES;
   PRIMARY FASCIAL CLOSURE; CRITICALLY-ILL PATIENTS; PERITONEAL-CAVITY OPEN
AB Aim Several techniques for temporary abdominal closure have been developed. We systematically review the literature on temporary abdominal closure to ascertain whether the method can be tailored to the indication. Method Medline, Embase, the Cochrane Central Register of Controlled Trials and relevant meeting abstracts until December 2009 were searched using the following headings: open abdomen, laparostomy, VAC (vacuum assisted closure), TNP (topical negative pressure), fascial closure, temporary abdominal closure, fascial dehiscence and deep wound dehiscence. The data were analysed by closure technique and aetiology. The primary end-points included delayed fascial closure and in-hospital mortality. The secondary end-points were intra-abdominal complications. Results The search identified 106 papers for inclusion. The techniques described were VAC (38 series), mesh/sheet (30 series), packing (15 series), Wittmann patch (eight series), Bogota bag (six series), dynamic retention sutures (three series), zipper (15 series), skin only and locking device (one series each). The highest facial closure rates were seen with the Wittmann patch (78%), dynamic retention sutures (71%) and VAC (61%). Conclusion Temporary abdominal closure has evolved from simple packing to VAC based systems. In the absence of sepsis Wittmann patch and VAC offered the best outcome. In its presence VAC had the highest delayed primary closure and the lowest mortality rates. However, due to data heterogeneity only limited conclusions can be drawn from this analysis.
C1 [Quyn, A. J.; Johnston, C.; Hall, D.; Chambers, A.; Arapova, N.; Amin, A. I.] Fife NHS Trust, Victoria Hosp, Dept Gen Surg, Kirkcaldy KY2 5AH, Fife, Scotland.
   [Quyn, A. J.; Ogston, S.] Univ Dundee, Ninewells Hosp & Med Sch, Sch Med, Dundee DD1 9SY, Scotland.
C3 University of Dundee
RP Quyn, AJ (通讯作者)，Fife NHS Trust, Victoria Hosp, Dept Gen Surg, Hayfield Rd, Kirkcaldy KY2 5AH, Fife, Scotland.
EM aamin1@nhs.net
RI Johnston, Chris/ABC-5875-2020; Chambers, Adam Christian/HGU-5326-2022
OI Johnston, Chris/0000-0001-9935-7365; Quyn, Aaron/0000-0002-4333-5658;
   Chambers, Adam Christian/0000-0002-3215-0535
CR Abbott DE, 2007, AM SURGEON, V73, P1224
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NR 126
TC 122
Z9 141
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD AUG
PY 2012
VL 14
IS 8
BP E429
EP E438
DI 10.1111/j.1463-1318.2012.03045.x
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 980NX
UT WOS:000306901200001
PM 22487141
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Ludusanu, A
   Tanevscki, A
   Costârnache, RS
   Corlade-Andrei, M
   Soroceanu, PR
   Vintila, D
   Abdulan, IM
   Zabara, ML
   Balan, G
AF Ciuntu, Bogdan-Mihnea
   Ludusanu, Andreea
   Tanevscki, Adelina
   Costarnache, Rares Stefan
   Corlade-Andrei, Mihaela
   Soroceanu, Petru Radu
   Vintila, Dan
   Abdulan, Irina Mihaela
   Zabara, Mihai-Lucian
   Balan, Gheorghe
TI EndoVAC Therapy for Post-TEVAR Secondary Esophageal Fistula: A Rare Case
   of Delayed Secondary Esophageal Fistula After TEVAR Managed with
   Endoluminal Vacuum Therapy
SO LIFE-BASEL
LA English
DT Article
DE aorto-esophageal fistula; secondary esophageal fistula; thoracic
   endovascular aortic repair (TEVAR); endograft erosion; multidisciplinary
   approach
ID ENDOVASCULAR AORTIC REPAIR; AORTOESOPHAGEAL FISTULA; SOCIETY
AB Background: Aorto-esophageal fistula is a rare but life-threatening condition most often linked to thoracic aortic aneurysms and significant upper gastrointestinal bleeding. Thoracic endovascular aortic repair (TEVAR) is a crucial, life-saving procedure, but delayed complications, such as secondary esophageal fistulas caused by endograft erosion, can develop. Prompt recognition and multidisciplinary management are vital for survival. Case Presentation: We describe a 57-year-old patient with cardiovascular comorbidities and a saccular thoracic aortic aneurysm, who initially presented with massive hematemesis, melena, and hemodynamic instability. Imaging showed an aorto-esophageal fistula. Emergency treatment included placing a fully covered esophageal stent followed by TEVAR. Three weeks later, he experienced fever, chest pain, and worsening dysphagia. Laboratory tests indicated elevated inflammatory markers and hypoalbuminemia. Computed tomography revealed a new retrocardial esophageal fistula at T9, caused by mechanical erosion from the thoracic endograft. Endoluminal vacuum-assisted closure (EndoVAC) therapy was performed, leading to clinical improvement and the return of esophageal function. Conclusions: This case highlights a rare instance of a delayed secondary esophageal fistula after TEVAR beneath a preexisting stent, likely due to chronic contact between the endograft and esophagus. Despite advancements in endoscopic therapy, secondary fistulas after TEVAR are associated with high morbidity. Early diagnosis, aggressive infection management, structured nutritional support, and a multidisciplinary approach are essential. Extraluminal or intraluminal vacuum-assisted closure offers a promising minimally invasive option for managing complex esophageal defects.
C1 [Ciuntu, Bogdan-Mihnea; Ludusanu, Andreea; Tanevscki, Adelina; Soroceanu, Petru Radu; Vintila, Dan; Zabara, Mihai-Lucian] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Gen Surg, Iasi 700115, Romania.
   [Ciuntu, Bogdan-Mihnea; Ludusanu, Andreea; Tanevscki, Adelina; Soroceanu, Petru Radu; Vintila, Dan; Zabara, Mihai-Lucian] St Spiridon Cty Emergency Clin Hosp, Gen Surg Clin, 1 Independence Blvd, Iasi 700111, Romania.
   [Costarnache, Rares Stefan] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Univ Med & Pharm Grigore T Popa, Dept Emergency Med, Surg 2, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela] Univ Med & Pharm Grigore T Popa, Dept Med Specialties 1, Iasi 700115, Romania.
   [Balan, Gheorghe] Univ Med & Pharm Grigore T Popa, Dept Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Costârnache, RS (通讯作者)，Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.; Abdulan, IM (通讯作者)，Univ Med & Pharm Grigore T Popa, Dept Med Specialties 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; andreealudusanu1106@yahoo.com;
   papancea.adelina@umfiasi.ro; rcostarnache@yahoo.com;
   mihaela.corlade2@umfiasi.ro; petru.soroceanu@umfiasi.ro;
   dan.vintila@umfiasi.ro; irina.abdulan@yahoo.com;
   mihai-lucian.zabara@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Ciuntu, Bogdan/MTF-9477-2025; Corlade-Andrei, Mihaela/HGB-3725-2022;
   Abdulan, Irina/AAA-3089-2020
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NR 24
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR 11
PY 2026
VL 16
IS 3
AR 460
DI 10.3390/life16030460
PG 9
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA FS6RP
UT WOS:001726453600001
PM 41900978
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nather, A
   Chionh, SB
   Han, AYY
   Chan, PPL
   Nambiar, A
AF Nather, Aziz
   Chionh, Siok Bee
   Han, Audrey Y. Y.
   Chan, Pauline P. L.
   Nambiar, Ajay
TI Effectiveness of Vacuum-assisted Closure (VAC) Therapy in the Healing of
   Chronic Diabetic Foot Ulcers
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE Diabetic foot wound; Negative pressure dressing; Wound healing
ID WOUNDS
AB Introduction: This is the first prospective study done locally to determine the effectiveness of vacuum-assisted closure (VAC) therapy in the healing of chronic diabetic foot ulcers. Materials and Methods: An electronic vacuum pump was used to apply controlled negative pressure evenly across the wound surface. Changes in wound dimension, presence of wound granulation and infection status of diabetic foot ulcers in 11 consecutive patients with diabetes were followed over the course of VAC therapy. Results: Healing was achieved in all wounds. Nine wounds were closed by split-skin grafting and 2 by secondary closure. The average length of treatment with VAC therapy was 23.3 days. Ten wounds showed reduction in wound size. All wounds were satisfactorily granulated and cleared of bacterial infection at the end of VAC therapy. Conclusions: VAC therapy was useful in the treatment of diabetic foot infection and ulcers, which after debridement, may present with exposed tendon, fascia and/or bone. These included ray amputation wounds, wounds post-debridement for necrotising fasciitis, wounds post-drainage for abscess, a heel ulcer and a sole ulcer. It was able to prepare ulcers well for closure via split-skin grafting or secondary closure in good time. This reduced cost of VAC therapy, as therapy was not prolonged to attain greater reduction in wound area. VAC therapy also provides a sterile, more controlled resting environment to large, exudating wound surfaces. Large diabetic foot ulcers were thus made more manageable. Ann Acad Med Singapore 2010;39:353-8
C1 [Nather, Aziz; Han, Audrey Y. Y.; Chan, Pauline P. L.; Nambiar, Ajay] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthopaed Surg, Singapore 119074, Singapore.
   [Chionh, Siok Bee] Natl Univ Hlth Syst, Dept Med, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore
RP Nather, A (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthopaed Surg, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore.
EM dosnathe@nus.edu.sg
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NR 17
TC 47
Z9 58
U1 2
U2 21
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD MAY
PY 2010
VL 39
IS 5
BP 353
EP 358
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 606OF
UT WOS:000278435400003
PM 20535423
DA 2026-07-24
ER

PT J
AU Leffler, M
   Derrick, KL
   McNulty, A
   Malsiner, C
   Dragu, A
   Horch, RE
AF Leffler, Mareike
   Derrick, Kathleen L.
   McNulty, Amy
   Malsiner, Caye
   Dragu, Adrian
   Horch, Raymund E.
TI Changes of anabolic processes at the cellular and molecular level in
   chronic wounds under topical negative pressure can be revealed by
   transcriptome analysis
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE topical negative pressure; reticulated open cell foam; vacuum assisted
   closure therapy; microarray; quantitative real time PCR; transcriptome
   analysis
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; TISSUE; THERAPY; MANAGEMENT;
   ULCERS; TRANSPLANTATION; PROLIFERATION; FIBROBLASTS; MEDICINE
AB Chronic wounds - as defined by the World Union of Wound Healing Societies (WUWHS) - are a considerable worldwide health care expense and impair quality of life. In order for chronic wounds to heal, these wounds must be transformed to a more acute state to begin the healing process. Topical negative pressure (TNP) with reticulated open cell foam (ROCF) is known to promote healing in certain types of chronic wounds. However, little is known about changes at the cellular or molecular level in wounds under various treatments, especially under the physical forces induced to tissue by TNP. In the current study, chronic wound samples were obtained during routine wound debridements prior to treatment and 7-12 days after initiating TNP with a continuous setting at -125 mmHg. Whole genome transcriptome microarray analyses were performed on samples to better understand how TNP with ROCF affects these types of wounds. It was found that more genes were expressed following TNP with ROCF as compared to before therapy and to normal, non-wounded tissue. In this study, we show that TNP with ROCF transforms the chronic wound from its inflammation (non-healing) state into more of a progressive, healing phenotype from a molecular point of view with expression of genes that are commonly associated with these terms.
C1 [Leffler, Mareike; Malsiner, Caye; Dragu, Adrian; Horch, Raymund E.] Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   [Derrick, Kathleen L.; McNulty, Amy] Kinet Concepts Inc, San Antonio, TX USA.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Univ Hosp, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@uk-erlangen.de
RI Dragu, Adrian/AAH-3506-2019; Horch, Raymund E/H-8128-2019
OI Dragu, Adrian/0000-0003-4633-2695; Horch, Raymund E/0000-0002-6561-2353
FU Kinetic Concepts Inc. [VACP 2005-17]; Erlangen University [Fe 34499008]
FX Preliminary data of this study have been presented at the
   Drei-Lander-Kongress on VAC Therapy in Zurich, 16 April 2010 and have
   been printed in the supplementary abstract issue of the Zeitschrift fur
   Wundheilung. This study was supported by a research grant of Kinetic
   Concepts Inc. to the Friedrich-Alexander-University of
   Erlangen-Nuernberg (Grant Nr. VACP 2005-17; Erlangen University Nr. Fe
   34499008). The study was approved by the Ethical committee
   Friedrich-Alexander-University of Erlangen-Nuernberg clearance: Nr.
   3343. We thank PD Dr. med. Ulrich Kneser for operating the clinical
   cases presented in Figures 1 and 2.
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NR 49
TC 13
Z9 15
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUL
PY 2011
VL 15
IS 7
BP 1564
EP 1571
DI 10.1111/j.1582-4934.2010.01147.x
PG 8
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 783RI
UT WOS:000292101300012
PM 20716124
OA Bronze
DA 2026-07-24
ER

PT J
AU Simsek, HU
   Tatar, OC
   Simsek, T
AF Simsek, Hayal Uzelli
   Tatar, Ozan Can
   Simsek, Turgay
TI Vulvar necrotizing wounds: Unveiling mortality-associated parameters and
   assessing the efficacy of VAC therapy
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Infection; Necrotizing Fasciitis; Wound; Vacuum-Assisted Closure
ID FOURNIERS GANGRENE; ASSISTED CLOSURE; FASCIITIS; COHORT
AB Introduction: Vulvar Necrotizing Fasciitis (VNF) is a critical, severe soft tissue infection characterized by aggressive progression and significant morbidity and mortality. Rapid diagnosis and immediate, comprehensive treatment, including antibiotic therapy, meticulous surgical debridement, and multidisciplinary care, are crucial for improving outcomes. This study aimed to investigate mortality-related factors in VNF and evaluate treatment modalities, focusing on Vacuum-Assisted Closure (VAC) therapy versus traditional debridement. Methods: This retrospective study analyzed data from 22 VNF patients. Criteria included adults diagnosed with vulvar necrotizing infections, excluding those transferred or not completing treatment at the center. The study examined mortality-related factors and the efficacy of VAC therapy compared to debridement, considering treatment costs and outcomes. Results: Analysis divided patients into survivors (13) and non-survivors (9). Higher heart rate, elevated WBC and CRP levels, and higher Clavien-Dindo scores were associated with increased mortality. VAC therapy, compared to traditional debridement, resulted in significantly lower CRP levels and reduced treatment costs. However, other parameters such as the length of hospital stay and debridement frequency showed no significant differences. Conclusion: The study highlights that older age, systemic inflammation, and severe postoperative complications are key factors associated with higher mortality in VNF. VAC therapy emerges as a promising modality, effectively reducing systemic inflammation and healthcare costs. Nonetheless, the retrospective nature and the small sample size of the study limit the generalizability of the findings. Future research, particularly larger, multicentric studies, is essential to further explore and validate the effectiveness of VAC therapy in VNF management.
C1 [Simsek, Hayal Uzelli] Kocaeli Univ, Dept Gynecol & Obstet, Izmit, Turkiye.
   [Tatar, Ozan Can; Simsek, Turgay] Kocaeli Univ, Dept Gen Surg, Izmit, Turkiye.
C3 Kocaeli University; Kocaeli University
RP Tatar, OC (通讯作者)，Kocaeli Univ, Dept Gen Surg, Izmit, Turkiye.
EM ozancantatar@gmail.com
RI şimşek, hayal uzelli/AAB-3626-2022; Tatar, Ozan/AAR-8524-2020; ŞİMŞEK,
   Turgay/AAS-1708-2020
OI şimşek, hayal uzelli/0000-0002-1197-1326; 
CR Afzal M, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.46140
   Allaw F, 2024, CURR OPIN INFECT DIS, V37, P105, DOI 10.1097/QCO.0000000000000988
   Assenza M, 2011, CLIN TER, V162, pE1
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   Harbrecht BG, 2016, SURG INFECT, V17, P503, DOI 10.1089/sur.2016.049
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   Wood SC, 2015, CLIN OBSTET GYNECOL, V58, P503, DOI 10.1097/GRF.0000000000000131
NR 18
TC 0
Z9 0
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD DEC
PY 2024
VL 303
BP 48
EP 52
DI 10.1016/j.ejogrb.2024.10.022
EA OCT 2024
PG 5
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA J4Z4A
UT WOS:001337159700001
PM 39413549
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Perentes, JY
   Abdelnour-Berchtold, E
   Blatter, J
   Lovis, A
   Ris, HB
   Krueger, T
   Gonzalez, M
AF Perentes, Jean Yannis
   Abdelnour-Berchtold, Etienne
   Blatter, Jeannine
   Lovis, Alban
   Ris, Hans-Beat
   Krueger, Thorsten
   Gonzalez, Michel
TI Vacuum-assisted closure device for the management of infected
   postpneumonectomy chest cavities
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID ACCELERATED TREATMENT; MUSCLE TRANSPOSITION; EMPYEMA; THERAPY;
   EXPERIENCE
AB Background: Infected postpneumonectomy chest cavities may be related to chronic postpneumonectomy empyema or arise in rare situations of necrotizing pneumonia with complete lung destruction where pneumonectomy and pleural debridement are required. We evaluated the safety and efficacy of an intrathoracic vacuum-assisted closure device (VAC) for the treatment of infected postpneumonectomy chest cavities.
   Method: A retrospective single institution review of all patients with infected postpneumonectomy chest cavities treated by VAC between 2005 and 2013. Patients underwent surgical debridement of the thoracic cavity, muscle flap closure of the bronchial stump when a fistula was present, and repeated intrathoracic VAC dressings until granulation tissue covered the entire chest cavity. After this, the cavity was obliterated by a Clagett procedure and closed.
   Results: Twenty-one patients (14 men and 7 women) underwent VAC treatment of their infected postpneumonectomy chest cavity. Twelve patients presented with a chronic postpneumonectomy empyema (10 of them with a bronchopleural fistula) and 9 patients with an empyema occurring in the context of necrotizing pneumonia treated by pneumonectomy. In-hospital mortality was 23%. The median duration of VAC therapy was 23 days (range, 4-61 days) and the median number of VAC changes per patient was 6 (range, 2-14 days). Infection control and successful chest cavity closure was achieved in all surviving patients. One adverse VAC treatment-related event was identified (5%).
   Conclusions: The intrathoracic VAC application is a safe and efficient treatment of infected postpneumonectomy chest cavities and allows the preservation of chest wall integrity.
C1 [Perentes, Jean Yannis; Abdelnour-Berchtold, Etienne; Blatter, Jeannine; Ris, Hans-Beat; Krueger, Thorsten; Gonzalez, Michel] CHU Vaudois, Div Thorac Surg, CH-1011 Lausanne, Switzerland.
   [Lovis, Alban] CHU Vaudois, Div Pneumol, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Gonzalez, M (通讯作者)，CHU Vaudois, Div Thorac Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM Michel.Gonzalez@chuv.ch
RI ; Krueger, Thorsten/AAK-1780-2021
OI Perentes, Jean/0000-0001-7918-0793; gonzalez,
   michel/0000-0001-8705-4279; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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   Liberman M, 2007, SEMIN THORAC CARDIOV, V19, P366, DOI 10.1053/j.semtcvs.2007.11.002
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   Schimmer C, 2008, THORAC CARDIOV SURG, V56, P200, DOI 10.1055/s-2008-1038386
   Schintler M, 2005, BURNS, V31, P1050, DOI 10.1016/j.burns.2005.03.003
   Schneiter D, 2001, ANN THORAC SURG, V72, P1668, DOI 10.1016/S0003-4975(01)03083-1
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   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
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   Webster J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub2
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   Zaheer S, 2006, ANN THORAC SURG, V82, P279, DOI 10.1016/j.athoracsur.2006.01.052
NR 26
TC 23
Z9 34
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD MAR
PY 2015
VL 149
IS 3
BP 745
EP 750
DI 10.1016/j.jtcvs.2014.10.052
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CE6EX
UT WOS:000351930600038
PM 25454910
OA Bronze
DA 2026-07-24
ER

PT J
AU Scholl, L
   Chang, E
   Reitz, B
   Chang, J
AF Scholl, L
   Chang, E
   Reitz, B
   Chang, J
TI Sternal osteomyelitis: Use of vacuum-assisted closure device as an
   adjunct to definitive closure with sternectomy and muscle flap
   reconstruction
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID WOUND COMPLICATIONS; MANAGEMENT; MEDIASTINITIS; EXPERIENCE; BRIDGE
AB Objectives: Sternal osteomyelitis following cardiac surgery often requires debridement and flap coverage. The VAC (vacuum-assisted closure) device has been useful in complex wound coverage. A retrospective review of a single surgeon's experience with sternal reconstruction using the VAC device as an adjunct to debridement and muscle flap reconstruction was performed. Methods: Thirteen consecutive patients over a 34-month period underwent debridement and reconstruction of sternal wounds. Eleven patients (85%) were males, and two (15%) were females. Mean age was 61 years (range: 43-73 years). Acute purulent sternal infections occurred in seven patients, while chronic sternal osteomyelitis was seen in six patients. Use of the VAC device during the perioperative period was evaluated. Results: Of the 13 patients, the VAC device was used prior to flap closure in six patients, and after flap closure in two patients. Sternal debridement with bilateral pectoralis muscle flaps was used to reconstruct 12 patients, and one patient underwent debridement only with VAC placement. All 13 patients (100%) had complete closure of their complex wounds at an average of follow-up of 14 months. Conclusions: The VAC device is useful in the treatment of sternal osteomyelitis in three contexts: (1) as a temporary wound care technique preoperatively that minimizes dressing changes and prevents shear stresses of an open sternum, (2) as the sole method of wound closure in specific cases, and (3) as a technique to facilitate healing in postoperative flap reconstruction cases complicated by reinfection.
C1 Stanford Univ, Med Ctr, Div Plast & Reconstruct Surg, Dept Surg, Stanford, CA USA.
   Stanford Univ, Med Ctr, Dept Cardiothorac Surg, Stanford, CA USA.
C3 Stanford University; Stanford University
RP Chang, J (通讯作者)，Stanford Univ, Med Ctr, Div Plast Surg, 770 Welch Rd,Suite 400, Stanford, CA 94305 USA.
EM changhand@aol.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ARNOLD PG, 1989, SURG CLIN N AM, V69, P1081
   ARNOLD PG, 1994, PLAST RECONSTR SURG, V93, P324, DOI 10.1097/00006534-199402000-00015
   Golosow LM, 1999, ANN PLAS SURG, V43, P30, DOI 10.1097/00000637-199907000-00005
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
   Hersh RE, 2001, HEART SURG FORUM, V4, P211
   HUGO NE, 1994, PLAST RECONSTR SURG, V93, P1433, DOI 10.1097/00006534-199406000-00016
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   Lindsey JT, 2002, PLAST RECONSTR SURG, V109, P1882, DOI 10.1097/00006534-200205000-00015
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   Tang A T, 2000, J Wound Care, V9, P229
NR 15
TC 42
Z9 53
U1 0
U2 3
PU BLACKWELL FUTURA PUBLISHING, INC
PI MALDEN
PA 350 MAIN STREET, MALDEN, MA 01248-5018 USA
SN 0886-0440
J9 J CARDIAC SURG
JI J. Card. Surg.
PD SEP-OCT
PY 2004
VL 19
IS 5
BP 453
EP 461
DI 10.1111/j.0886-0440.2004.05002.x
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 858LD
UT WOS:000224192400016
PM 15383060
DA 2026-07-24
ER

PT J
AU Mokhtari, A
   Petzina, R
   Gustafsson, L
   Sjögren, J
   Malmsjö, M
   Ingemansson, R
AF Mokhtari, Arash
   Petzina, Rainer
   Gustafsson, Lotta
   Sjogren, Johan
   Malmsjo, Malin
   Ingemansson, Richard
TI Sternal stability at different negative pressures during vacuum-assisted
   closure therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID MEDIASTINITIS; INFECTIONS
AB Background. Vacuum-assisted closure (VAC) is a widely used therapy in patients with poststernotomy mediastinitis. The aim of this study was to evaluate sternal stability during VAC application at seven negative pressures (-50 to -200 mm Hg) in a porcine wound model.
   Methods. Six pigs underwent median sternotomy and 2 steel wires were fixed at each sternal side and connected to a traction device. The device was connected to a force transducer linked to a force recorder. VAC therapy was applied to the wound. At each negative pressure, the length and width of the wound were measured before and after traction was started. Traction was increased stepwise up to 400 N.
   Results. The diastasis induced by a certain lateral force was similar in wounds treated with -75, -125, and -175 mm Hg. At -75 mm Hg, a significant improvement (p < 0.01) in sternal stability was seen compared with the open-chest setting. This was not further improved at -125 or -175 mm Hg. High negative pressures (-150 to -200 mm Hg) in combination with a high lateral force (> 200 N) increased the risk of separation of the foam from the wound edges, with air leakage or organ rupture as a result.
   Conclusions. Our results suggest that low negative pressures (-50 to -100 mm Hg) stabilize the sternum as efficiently as high negative pressures (-150 to -200 mm Hg). Low negative pressures (-50 to -100 mm Hg) were more beneficial, however, because no air leakage or organ rupture was observed at these pressures.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Internal Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Mokhtari, A (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM arash.mokhtari@med.lu.se
RI ; Sjögren, Johan/AAZ-6448-2021
OI Gustafsson, Lotta/0000-0002-9826-9133; Maljö, Malin/0000-0001-9849-9599;
   Petzina, Rainer/0000-0002-0688-5482; Ingemansson,
   Richard/0000-0001-7623-8953
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Domkowski PW, 2003, J THORAC CARDIOV SUR, V126, P386, DOI 10.1016/S0022-5223(03)00352-0
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Fleck TM, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00189-9
   Gustafsson R, 2002, J THORAC CARDIOV SUR, V123, P895, DOI 10.1067/mtc.2002.121306
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
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   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Sjögren J, 2004, J HEART LUNG TRANSPL, V23, P506, DOI 10.1016/S1053-2498(03)00224-9
   Sjogren Johan, 2004, Interact Cardiovasc Thorac Surg, V3, P666, DOI 10.1016/j.icvts.2004.08.003
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 17
TC 34
Z9 43
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2006
VL 82
IS 3
BP 1063
EP 1067
DI 10.1016/j.athoracsur.2006.04.085
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 076ZD
UT WOS:000239996300045
PM 16928538
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Schipper, J
   Ridder, GJ
   Maier, W
   Horch, RE
AF Schipper, J
   Ridder, GJ
   Maier, W
   Horch, RE
TI The preconditioning and prelamination of pedicled and free microvascular
   anastomised flaps with the technique of vacuum assisted closure
SO LARYNGO-RHINO-OTOLOGIE
LA German
DT Article; Proceedings Paper
CT 46th Austrian HNO Congress
CY SEP 18-22, 2002
CL FLEDKIRCH, AUSTRIA
DE atmospheric pressure; granulation tissue; wound healing;
   neovascularization; surgical flaps
ID SUBATMOSPHERIC PRESSURE; CLINICAL IMPLICATIONS; WOUND CONTROL;
   ANGIOSOMES; THERAPY; ULCERS; BODY
AB Background: Since the technique of vacuum assisted closure has been clinically introduced, the possibilities in reconstructive head and neck surgery have greatly increased. Preconditioning and prelaminating allows a pedicled or free flap plasty to be epithelialized on both sides before the flap gets transferred to its future location. Methods: We describe the technique of preconditioning and prelaminating of pedicled and free microvascular anastomised flap plasties and we report our experience with 5 cases. Our results are compared with data from the literature. Results: The procedures concerned take only little time and the flap gets optimally prepared for its task in view of the postoperatively modified hemodynamics. By preconditioning, the flap to be lifted is prepared for the future centralised blood supply exclusively via the pedicle vessel without leaving the donor side. Thereby the skin island of such flaps can be increased in size over the natural angiosomes without an increased risk of necrotisation. Conclusions: By the technique of prelamination, skin or mucosa tissue may be applied onto both sides of the flap so that it can resist the biochemical and mechanical tasks which will be required after transposition. Especially for the reconstruction of defects in the upper aerodigestive tract this is a great advantage, since the inner side of the flap has to resist saliva which represents one of the most aggressive secretions in the human body.
C1 Univ Freiburg Klinikum, Univ Klin Hals Nasen & Ohrenheilkunde & Poliklin, D-79106 Freiburg, Germany.
   Univ Freiburg Klinikum, Chirurg Univ Klin, Abt Plast & Handchirurg, D-79106 Freiburg, Germany.
C3 University of Freiburg; University of Freiburg
RP Schipper, J (通讯作者)，Univ Freiburg Klinikum, Univ Klin Hals Nasen & Ohrenheilkunde & Poliklin, D-79106 Freiburg, Germany.
EM schipper@hno.ukl.uni-freiburg.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353; Ridder, Gerd J/0000-0002-9742-4437
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bauer P, 1998, Handchir Mikrochir Plast Chir, V30, P20
   COLWELL S, 1993, NEW STATESMAN SOC, V6, P28
   DALTREY DC, 1981, J CLIN PATHOL, V34, P701, DOI 10.1136/jcp.34.7.701
   Dhar SC, 1999, PLAST RECONSTR SURG, V104, P2079, DOI 10.1097/00006534-199912000-00021
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
   FLEISCHMANN W, 1995, OSTEOPOROSIS INT, V2, P2
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   GRISTINA AG, 1985, SCIENCE, V228, P990, DOI 10.1126/science.4001933
   HORCH R, 1994, VASA-J VASCULAR DIS, V23, P52
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   HORCH RE, 2000, J WOUND HEALING, V5, P3
   HORCH RE, 1993, BURNS, V19, P558
   HORCH RE, 2000, J WOUND HEALING, V5, P17
   Houseman ND, 2000, PLAST RECONSTR SURG, V105, P2287, DOI 10.1097/00006534-200006000-00001
   HUNT TK, 1988, ANN EMERG MED, V17, P1265, DOI 10.1016/j.mpsur.2017.06.004
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   LAUER G, 2000, COMMUNICATION
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
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   Zimmerli W, 1996, ANTIMICROB AGENTS CH, V40, P102, DOI 10.1128/AAC.40.1.102
NR 31
TC 18
Z9 18
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0935-8943
EI 1438-8685
J9 LARYNGO RHINO OTOL
JI Laryngo-Rhino-Otol.
PD JUN
PY 2003
VL 82
IS 6
BP 421
EP 427
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA 696YV
UT WOS:000183916100006
PM 12851850
DA 2026-07-24
ER

PT J
AU Andrews, BT
   Smith, RB
   Goldstein, DP
   Funk, GF
AF Andrews, Brian T.
   Smith, Russell B.
   Goldstein, David P.
   Funk, Gerry F.
TI Management of complicated head and neck wounds with vacuum-assisted
   closure system
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE vacuum-assisted closures; VAC; negative pressure dressing; head and neck
   wounds; scalping injuries; split-thickness skin grafts
ID SECURING SKIN-GRAFTS; PRESSURE
AB Background. The vacuum-assisted closure system (VA.C.), or negative pressure dressings, has been successfully used to manage complex wounds of the torso and extremities, but its role in the head and neck region has not been frequently described.
   Methods. A retrospective study was performed. The V.A.C. system (Kinetic Concepts Inc., San Antonio, TX) was used at the University of Iowa Hospitals and Clinics for management of complicated head and neck wounds.
   Results. The V.A.C. system was utilized at 13 sites for 12 patients. Nine subjects had exposed calvarium (4 had failed pedided reconstructive flaps, 3 had ablative or Moh's defects, and 2 had traumatic scalping injuries) necessitating bony coverage. Three subjects had the V.A.C. system used as a bolster dressing placed over split-thickness skin grafts (STSGs) used to reconstruct large defects of the face and skull, and 1 patient had a large soft tissue neck defect after radical surgical resection for necrotizing fascitis. One subject used the V.A.C. system for the management of 2 distinct wounds. All patients had successful healing of their wounds with the V.A.C. system without complication. All STSGs had 100% viability after 5 to 7 days of the VA.C. system use as a bolster dressing.
   Conclusion. This study demonstrates the V.A.C. system is a valuable tool in the management of complicated head and neck wounds. (c) 2006 Wiley Periodicals, Inc.
C1 Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Andrews, BT (通讯作者)，Univ Iowa Hosp & Clin, Dept Otolaryngol Head & Neck Surg, 21200 Pomerantz Pavill,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM brian-andrews@uiowa.edu
RI goldstein, David/AAT-6302-2020
OI Andrews, Brian/0000-0003-3994-6808
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Greer S E, 1999, J Wound Ostomy Continence Nurs, V26, P250
   Loree S, 2004, J Wound Care, V13, P249
   Miller Quintessa, 2004, Curr Surg, V61, P205, DOI 10.1016/j.cursur.2003.07.015
   Molnar JA, 2000, PLAST RECONSTR SURG, V105, P174, DOI 10.1097/00006534-200001000-00030
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   WINTERS HAH, 1994, INJURY, V25, P439, DOI 10.1016/0020-1383(94)90269-0
NR 11
TC 56
Z9 61
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD NOV
PY 2006
VL 28
IS 11
BP 974
EP 981
DI 10.1002/hed.20496
PG 8
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 097PL
UT WOS:000241460300002
PM 16983694
DA 2026-07-24
ER

PT J
AU López-Cano, M
   Armengol-Carrasco, M
AF Lopez-Cano, M.
   Armengol-Carrasco, M.
TI Use of vacuum-assisted closure in open incisional hernia repair: a novel
   approach to prevent seroma formation
SO HERNIA
LA English
DT Article
DE Hernia; Seroma; Prevention
ID PREDICTORS; DEVICE
AB Frequent complications in incisional hernia surgery are re-herniation, wound infection and seroma formation. The use of subatmospheric pressure dressings such as the vacuum-assisted closure (VAC) device has been shown to be an effective way to accelerate healing of various wounds. Here, we describe the application of the VAC device as a postoperative dressing to prevent seroma formation after open incisional hernia repair.
   Three consecutive patients (63, 65 and 60 years of age, respectively) underwent incisional hernia repair. Patient body mass index was 30.9, 26.6 and 29 kg/m(2), respectively. All hernias were complex with a defect size greater than 10 cm and were repaired using the onlay technique. After suture skin closure the incision was covered with a thin VAC sponge (KCI, San Antonio, TX) that was set at -125 mm Hg and left in place for 5 days before removal.
   An abdominal CT scan performed before discharge from the hospital did not show seroma formation. Physical examination 3 months after surgery was normal with no evidence of seroma (abdominal bulge and/or fluid wave).
   This successful preliminary experience in three patients encourages the use of the VAC system in incisional hernia repair, particularly in selected patients with risk factors for seroma formation (e.g., large defects, obesity, patient comorbidities, nutritional status, number of prior abdominal incisions, etc.). Therefore, prevention of seroma formation after incisional hernia repair may be added as a novel application of the VAC device.
C1 [Lopez-Cano, M.; Armengol-Carrasco, M.] Hosp Univ Vall dHebron, Dept Surg, Abdominal Wall Unit, Barcelona 08035, Spain.
C3 Hospital Universitari Vall d'Hebron
RP López-Cano, M (通讯作者)，Hosp Univ Vall dHebron, Dept Surg, Abdominal Wall Unit, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
EM manulopez@vhebron.net
RI López-Cano, Manuel/H-2465-2011
OI López-Cano, Manuel/0000-0002-7993-9453; Armengol Carrasco,
   Manuel/0000-0002-3211-3195
CR Bendavid R, 2001, ABDOMINAL WALL HERNI, P753
   Kaafarani HMA, 2009, AM J SURG, V198, P639, DOI 10.1016/j.amjsurg.2009.07.019
   Klink CD, 2010, HERNIA, V14, P175, DOI 10.1007/s10029-009-0603-1
   Klink CD, 2010, HERNIA, V15, P69
   Korenkov M, 2001, LANGENBECK ARCH SURG, V386, P65, DOI 10.1007/s004230000182
   Poelman MM, 2010, HERNIA, V14, P369, DOI 10.1007/s10029-010-0646-3
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 8
TC 21
Z9 25
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
J9 HERNIA
JI Hernia
PD FEB
PY 2013
VL 17
IS 1
BP 129
EP 131
DI 10.1007/s10029-011-0837-6
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 081BT
UT WOS:000314291300023
PM 21667262
DA 2026-07-24
ER

PT J
AU Eyileten, Z
   Akar, AR
   Eryilmaz, S
   Sirlak, M
   Yazicioglu, L
   Durdu, S
   Uysalel, A
   Ozyurda, U
AF Eyileten, Zeynep
   Akar, Ahmet Ruchan
   Eryilmaz, Sadik
   Sirlak, Mustafa
   Yazicioglu, Levent
   Durdu, Serkan
   Uysalel, Adnan
   Ozyurda, Umit
TI Vacuum-assisted closure and bilateral pectoralis muscle flaps for
   different stages of mediastinitis after cardiac surgery
SO SURGERY TODAY
LA English
DT Article
DE Sternotomy; Dehiscence; Deep sternal wound infection; Mediastinitis;
   Complications
ID STERNAL WOUND-INFECTION; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   SITE INFECTION; MANAGEMENT; MORTALITY; THERAPY; CLASSIFICATION;
   COMPLICATIONS; STERNOTOMY
AB To assess the results of bilateral pectoralis major muscle flaps (BPMMF) and vacuum-assisted closure (VAC) at different stages of postcardiac surgery mediastinitis.
   Of 65 patients with a deep sternal wound infection (DSWI) after cardiac surgery, 33 with a stable sternum were treated with VAC (59.3 +/- 11.7 years of age) and 32 with an unstable sternum or osteomyelitis (63.3 +/- 9.8 years of age) were treated with early BPMMF and continuous irrigation. Delayed BPMMF reconstruction was necessary in six VAC patients.
   The overall incidence of DSWI was 1.04% within the study period. Deep sternal wound infection was diagnosed 15.9 +/- 10.8 days (range 5-62 days) after surgery. Diabetes was more common in the BPMMF group than in the VAC group (P = 0.046). Hospital mortality after treatment was 4.6% (n = 3) overall. Causes of death were septic multiorgan failure and respiratory failure. The infective pathogens were methicillin-resistant Staphylococcus aureus (MRSA; n = 2) and Acinetobacter species (n = 1). The median hospital stay was 29 days (range 15-110 days). After 6 months, only one recurrent sternal infection had occurred in the VAC group.
   Early BPMMF is an effective surgical treatment for DSWI in patients with an unstable sternum and osteomyelitis. VAC may be considered for patients without osteomyelitis but a stable sternum, or as adjuvant therapy in patients with comorbidity.
C1 [Eyileten, Zeynep; Akar, Ahmet Ruchan; Eryilmaz, Sadik; Sirlak, Mustafa; Yazicioglu, Levent; Durdu, Serkan; Uysalel, Adnan; Ozyurda, Umit] Ankara Univ, Sch Med, Ctr Heart, Dept Cardiovasc Surg, TR-06340 Ankara, Turkey.
C3 Ankara University
RP Akar, AR (通讯作者)，Ankara Univ, Sch Med, Ctr Heart, Dept Cardiovasc Surg, TR-06340 Ankara, Turkey.
RI ; Akar, Ahmet Rüçhan/C-9905-2009; Şırlak, Mustafa/ABI-7443-2020
OI Durdu, Serkan/0000-0002-0578-1657; Şırlak, Mustafa/0000-0001-6806-7672
CR Baskett RJF, 1999, ANN THORAC SURG, V67, P462, DOI 10.1016/S0003-4975(98)01195-3
   Brunet F, 1996, J THORAC CARDIOV SUR, V111, P1200
   Bui TD, 2006, AM J SURG, V192, P235, DOI 10.1016/j.amjsurg.2006.01.013
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   Eklund AM, 2006, ANN THORAC SURG, V82, P1784, DOI 10.1016/j.athoracsur.2006.05.097
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Francel TJ, 2001, ANN THORAC SURG, V72, P1419, DOI 10.1016/S0003-4975(00)02009-9
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   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
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   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   Mangram AJ, 1999, AM J INFECT CONTROL, V27, P97, DOI 10.1016/S0196-6553(99)70088-X
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   OTTINO G, 1987, ANN THORAC SURG, V44, P173, DOI 10.1016/S0003-4975(10)62035-8
   Rand RP, 1998, ANN THORAC SURG, V65, P1046, DOI 10.1016/S0003-4975(98)00087-3
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   Shroyer ALW, 2003, ANN THORAC SURG, V75, P1856, DOI 10.1016/S0003-4975(03)00179-6
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Tang Gilbert H L, 2004, Semin Thorac Cardiovasc Surg, V16, P62
   Trick WE, 2000, J THORAC CARDIOV SUR, V119, P108, DOI 10.1016/S0022-5223(00)70224-8
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 26
TC 26
Z9 29
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD NOV
PY 2009
VL 39
IS 11
BP 947
EP 954
DI 10.1007/s00595-008-3982-5
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 514UA
UT WOS:000271419900005
PM 19882316
DA 2026-07-24
ER

PT J
AU Senturk, A
   Gonullu, E
   Bayhan, Z
   Akdeniz, Y
   Ozdemir, K
   Mantoglu, B
   Capoglu, R
   Firat, N
   Altintoprak, F
AF Senturk, A.
   Gonullu, E.
   Bayhan, Z.
   Akdeniz, Y.
   Ozdemir, K.
   Mantoglu, B.
   Capoglu, R.
   Firat, N.
   Altintoprak, F.
TI The wound area as a parameter guiding the timing of abdominal closure in
   the management of patients undergoing open abdominal procedures
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Abstract. - OBJECTIVE: Surgical site infec-; Open abdomen;
   Vacuum-assisted closure; Wound
ID NEUTROPHIL-LYMPHOCYTE RATIO; INFLAMMATORY RESPONSE; PREDICTIVE-VALUE;
   STRATEGIES; OUTCOMES; THERAPY; TRIAL
AB Objective: Surgical site infections (SSI) are incomparably troublesome and complicated, and some of them require an open abdomen (OA) procedure. While deciding the timing of abdominal closure, wound area calculation method and laboratory parameters can be used to guide the timing of abdominal closure after OA procedures. Patients and methods: The records of the patients who had undergone open abdomen during their treatment course and were followed up with vacuum-assisted closure (VAC) technique between December 2015 and December 2019 were retrospectively analyzed. The laboratory results before the first VAC application and the results after the VAC change were compared to determine a predictive parameter. The ImageJ program was used in five patients to compare the size of the wounds at the time of the decision to close them and before the first VAC application. Results: 102 patients were analyzed. The ratio of the last wound area to the wound area at the time of the first VAC application in five patients was 0.30, 0.41, 0.34, 0.27, 0.46 (mean: 0.36, standard deviation: 0.078) which were measured and calculated by ImageJ software. Conclusions: We think that the concept of wound reduction ratio, which was calculated by a computer program, can be used as a concrete equivalent of the wound closure eligibility criteria decided by clinical experience.
C1 [Senturk, A.; Gonullu, E.; Ozdemir, K.; Capoglu, R.] Sakarya Univ Training, Res Hosp, Gen Surg Dept, Sakarya, Turkiye.
   [Bayhan, Z.; Akdeniz, Y.; Mantoglu, B.; Firat, N.; Altintoprak, F.] Sakarya Univ, Gen Surg Dept, Fac Med, Sakarya, Turkiye.
C3 Sakarya University
RP Senturk, A (通讯作者)，Sakarya Univ Training, Res Hosp, Gen Surg Dept, Sakarya, Turkiye.
EM adem.senturk@saglik.gov.tr
RI Altintoprak, Fatih/JCD-8434-2023; CAPOGLU, Recayi/HKE-6308-2023;
   Şentürk, Adem/JNE-1643-2023; Mantoglu, Baris/ABD-2975-2020; Bayhan,
   Zulfu/AAB-8502-2020; GONULLU, Emre/AAK-7837-2021
OI Mantoglu, Baris/0000-0002-2161-3629; Bayhan, Zulfu/0000-0002-7587-7267;
   GONULLU, Emre/0000-0001-6391-4414
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 36
TC 0
Z9 0
U1 0
U2 16
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2023
VL 27
IS 23
BP 11361
EP 11369
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK2X0
UT WOS:001159340600020
PM 38095385
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Vasiluta, C
   Anton, N
   Ciuntu, R
   Damian, M
   Ciumanghel, A
   Blaj, M
   Azoicai, D
   Georgescu, SO
AF Ciuntu, Bogdan Mihnea
   Vasiluta, Ciprian
   Anton, Nicoleta
   Ciuntu, Roxana
   Damian, Mihaela
   Ciumanghel, Adi
   Blaj, Mihaela
   Azoicai, Doina
   Georgescu, Stefan Octavian
TI Negative Pressure Therapy in Abdominal Compartment Syndrome
SO REVISTA DE CHIMIE
LA English
DT Article
DE Negative pressure therapy; comportament syndrome; acute pancreatitis
ID EXPERIMENTAL DIABETES-MELLITUS; SEVERE ACUTE-PANCREATITIS;
   INTRAABDOMINAL PRESSURE; HYPERTENSION
AB The abdominal vacuum-assisted closure (VAC) system has been introduced, providing a new possibility to treat an open abdomen. Abdominal compartment syndrome has a great relevance in surgical practice and patient care in critical condition due to the effects of increased pressure in the enclosed space of the abdomen can lead to multiple organ failure. A prospective study was conducted on a sample of 15 patients with severe acute pancreatitis (SAP) was retrospectively analyzed, following the incidence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS), the effectiveness of the therapeutic methods applied in reducing the intra-abdominal pressure (PIA), the evolution of severity scores, lenght of stay in intensive care unit between January 2014 - March 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) -Hartman) in order to apply negative pressure to the open abdomen, while complying with specified settings in accordance with patients' outcome. Surgery for abdominal decompression in PAS with SCA is an emergency and was imposed on 14 of the 15 patients. In the studied group, the first decompression procedure was performed on days 2 to 5 from intake, as PIA increased in evolution despite medical methods. Only 1 patient hospitalized with SAP PIA decreased by medical methods and after haemofiltration. Acute severe pancreatitis remains a serious pathology in spite of a maximum medical and surgical therapy. Continuous venous haemofiltration has contributed to lowering intraabdominal pressure. Surgery with decompression vacuum systems with negative pressure lead to a significant decrease in PIA.
C1 [Ciuntu, Bogdan Mihnea; Vasiluta, Ciprian; Georgescu, Stefan Octavian] Grigore T Popa Univ Med & Pharm, Dept Surg, Fac Med, 16 Univ Str, Iasi 700115, Romania.
   [Anton, Nicoleta; Ciuntu, Roxana] Grigore T Popa Univ Med & Pharm, Dept Ophthalmol, Fac Med, 16 Univ Str, Iasi, Romania.
   [Damian, Mihaela; Ciumanghel, Adi; Blaj, Mihaela] Grigore T Popa Univ Med & Pharm, Dept Anesthesiol & Crit Care Med, Fac Med, 16 Univ Str, Iasi 700116, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm, Dept Prevent Med & Inderdisciplinar, Fac Med, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Surg, Fac Med, 16 Univ Str, Iasi 700115, Romania.; Blaj, M (通讯作者)，Grigore T Popa Univ Med & Pharm, Dept Anesthesiol & Crit Care Med, Fac Med, 16 Univ Str, Iasi 700116, Romania.
EM bogdanmciuntu@yahoo.com; miblaj@yahoo.com
RI Anton, Nicoleta/AAT-7014-2020; Ciuntu, Bogdan/MTF-9477-2025; Ciumanghel,
   Adi Ionut/FLP-2083-2022; AZOICAI, DOINA/HDO-6161-2022; Blaj,
   Mihaela/U-6090-2017
OI Anton, Nicoleta/0000-0002-4987-5049; Ciumanghel, Adi
   Ionut/0000-0001-5457-6636; AZOICAI, DOINA/0000-0003-0423-4085; 
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NR 17
TC 3
Z9 3
U1 0
U2 7
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD AUG
PY 2017
VL 68
IS 8
BP 1923
EP 1926
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FG5QV
UT WOS:000410388000050
DA 2026-07-24
ER

PT J
AU Mees, J
   Mardin, WA
   Senninger, N
   Bruewer, M
   Palmes, D
   Mees, ST
AF Mees, Julia
   Mardin, Wolf Arif
   Senninger, Norbert
   Bruewer, Matthias
   Palmes, Daniel
   Mees, Soeren Torge
TI Treatment options for postoperatively infected abdominal wall wounds
   healing by secondary intention
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Wound healing; Postoperative wound infection; Standardized treatment;
   Pathway
ID VACUUM-ASSISTED CLOSURE; DRESSINGS; MANAGEMENT; THERAPY
AB We present our current clinical approach for the treatment of postoperatively infected wounds of the abdominal wall healing by secondary intention that may help in the design of a randomized controlled trial to develop a standardized wound treatment pathway.
   Patients with postoperatively infected abdominal wounds treated with either Advanced Wound Care (AWC) dressings or vacuum-assisted closure (VAC) therapy were enrolled in the study. Follow-up was carried out prospectively for wound healing and incidence of incisional hernia at the earliest 3 years after surgery.
   Sixty-two patients were included and wounds were initially treated antiseptically for 5.19 +/- 2.91 days. Prior to VAC therapy, AWC dressings were applied for 8.75 +/- 2.93 days to reduce reinfection. Greater wound size (> 12 x 6 x 6cm) and extensive secretion (> 200 ml/day) argued for the VAC system. Overall incidence of incisional hernia was 20.4 %, with 18.4 % occurring in AWC-treated patients and 27.3 % in VAC-treated patients. Based on these results, a wound treatment pathway was established in our department.
   The established wound treatment pathway has helped to increase both workflow efficacy and outcome in the treatment of abdominal wounds. Wound size, amount of secretion, and status of infection were the parameters we used for the determination of appropriate treatment. The observational data gathered during the initiation of our pathway lay the basis for future randomized controlled trials that will determine the most appropriate treatment options in the setting of a standardized wound treatment pathway.
C1 [Mees, Julia; Mardin, Wolf Arif; Senninger, Norbert; Bruewer, Matthias; Palmes, Daniel; Mees, Soeren Torge] Univ Hosp Munster, Dept Gen & Visceral Surg, D-48149 Munster, Germany.
C3 University of Munster
RP Mees, ST (通讯作者)，Univ Hosp Munster, Dept Gen & Visceral Surg, Waldeyerstr 1, D-48149 Munster, Germany.
EM soerentorge.mees@ukmuenster.de
FU Systagenix Wound Management, Norderstedt, Germany
FX This project was funded by an unrestricted educational grant from
   Systagenix Wound Management, Norderstedt, Germany, formerly Johnson &
   Johnson Wound Management.
CR Baharestani MM, 2011, INT WOUND J, V8, P118, DOI 10.1111/j.1742-481X.2010.00756.x
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NR 18
TC 15
Z9 16
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1435-2443
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD DEC
PY 2012
VL 397
IS 8
BP 1359
EP 1366
DI 10.1007/s00423-012-0988-7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 050PR
UT WOS:000312067000022
PM 22875224
DA 2026-07-24
ER

PT J
AU Wu, YH
   Wang, JK
   Dai, JT
   Wang, G
   Li, HB
   Li, YG
   Wu, C
   Wei, GH
AF Wu, Yuhao
   Wang, Junke
   Dai, Jiangtao
   Wang, Gang
   Li, Hongbo
   Li, Yonggang
   Wu, Chun
   Wei, Guanghui
TI Is vacuum-assisted closure therapy feasible for children with deep
   sternal wound infection after cardiac surgery? The pooling results from
   current literature
SO ARTIFICIAL ORGANS
LA English
DT Article
DE children; congenital heart diseases; deep sternal wound infections;
   outcomes; vacuum&#8208; assisted closure
ID POST-STERNOTOMY MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; SYSTEM
AB Vacuum-assisted closure (VAC) has been used for children with deep sternal wound infections (DSWI); however, the safety and efficiency have not been determined. A meta-analysis was performed for outcomes of VAC therapy in children with DSWI after cardiac surgery. Electronic databases, including PubMed, Scopus, and Cochrane Library CENTRAL were searched systematically from January 1990 to October 2020 for the literature which reported the outcomes of VAC therapy for children with DSWI after cardiac surgery. Meta-regression and subgroup analyses were performed to find risk factors for prolonged length of VAC therapy and hospital stay. Eleven studies were included in this study, involving 217 subjects. VAC therapy was performed due to mediastinitis after congenital heart diseases (CHD) repair. In children with DSWI after cardiac surgery, length of VAC therapy, and hospital stay were 11.1 days (95% CI, 9.6-12.5 days) and 29.8 days (95% CI, 22.8-36.9 days), respectively. Incidence of infectious and wound-related complications was 8.5% (95% CI, 4.1%-13.0%). Overall mortality in this setting was 5.8% (95% CI, 2.5%-9.1%). In conclusion, in children with DSWI after cardiac surgery, length of VAC therapy and hospital stay were 11.1 and 29.8 days, respectively. Overall mortality was 5.8%. Although not significant, delayed chest closure, complex CHD, and Gram-negative bacilli/fungal infections may potentially contribute to prolonged duration of VAC treatment.
C1 [Wu, Yuhao; Dai, Jiangtao; Wang, Gang; Li, Hongbo; Li, Yonggang; Wu, Chun] Chongqing Med Univ, Dept Cardiothorac Surg, Childrens Hosp, Chongqing, Peoples R China.
   [Wu, Yuhao; Wang, Junke; Dai, Jiangtao; Wang, Gang; Li, Hongbo; Li, Yonggang; Wu, Chun; Wei, Guanghui] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, China Int Sci & Technol Cooperat Base Child Dev &, Minist Educ,Key Lab Child Dev & Disorders, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Wu, C; Wei, GH (通讯作者)，Chongqing Med Univ, Childrens Hosp, 136 Zhongshan Second Rd, Chongqing 400014, Peoples R China.
EM 250734291@qq.com; 250734291@qq.com
RI wang, jun ke/LFU-1628-2024
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NR 27
TC 8
Z9 11
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-564X
EI 1525-1594
J9 ARTIF ORGANS
JI Artif. Organs
PD AUG
PY 2021
VL 45
IS 8
BP 827
EP 837
DI 10.1111/aor.13936
EA MAR 2021
PG 11
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA TM0BA
UT WOS:000630082500001
PM 33569832
DA 2026-07-24
ER

PT J
AU Chen, K
   Lin, JT
   Sun, SB
   Lin, J
   Kong, JZ
   Tian, NF
AF Chen, Kai
   Lin, Jin-ti
   Sun, Shuai-bo
   Lin, Jian
   Kong, Jian-zhong
   Tian, Nai-feng
TI Vacuum-assisted closure combined with a closed suction irrigation system
   for treating postoperative wound infections following posterior spinal
   internal fixation
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE CSIS; Postoperative wound infection; Spinal surgery; VAC; Debridement;
   Wound healing
ID NEGATIVE-PRESSURE; TISSUE DEFECTS; THERAPY; FUSION; MANAGEMENT;
   DRAINAGE; EFFICACY
AB BackgroundWound infections after posterior spinal surgery are a troublesome complication; patients are occasionally forced to remove the internal fixation device, which can lead to instability of the spine and injury to the spinal cord. The purpose of this study was to evaluate the efficacy of modified vacuum-assisted closure (VAC) for treating an early postoperative spinal wound infection.MethodsWe conducted a retrospective study of 18 patients with wound infections after posterior spinal surgery from 2014 to 2017 at a single tertiary center. All patients included in the study received modified VAC treatment (VAC combined with a closed suction irrigation system, CSIS) until the wound satisfied the secondary closure conditions. Detailed information was obtained from the medical records.ResultsWound size decreased significantly after 1week of the modified VAC treatment. Three patients were treated with VAC three times and one patient received the VAC treatment four times; the remaining patients received the VAC treatment twice. The patients had excellent wound beds after an average of 8days. The wound healed completely after an average of 17days, and the average hospital stay was 33days. There was no recurrence of infection at the 1-year follow-up.ConclusionsThis study demonstrates that VAC combined with a CSIS is a safe, reliable, and effective method to treat a wound infection after spinal surgery. This improved VAC procedure provides an excellent wound bed to facilitate wound healing and shorten the hospital stay.
C1 [Chen, Kai; Kong, Jian-zhong] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Kong, Jian-zhong] Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Lin, Jin-ti; Sun, Shuai-bo; Lin, Jian; Tian, Nai-feng] Wenzhou Med Univ, Affiliated Hosp 2, Dept Spine Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Kai; Lin, Jin-ti; Sun, Shuai-bo; Lin, Jian; Tian, Nai-feng] Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, Zhejiang Spine Surg Ctr, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University
RP Kong, JZ (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Kong, JZ (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Tian, NF (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 2, Dept Spine Surg, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Tian, NF (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Med Sch 2, Zhejiang Spine Surg Ctr, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
EM chenkai1809@163.com; jzkongfey@126.com; tiannaifeng@163.com
OI Chen, Kai/0000-0001-6850-1723
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NR 28
TC 13
Z9 15
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC 17
PY 2018
VL 13
AR 321
DI 10.1186/s13018-018-1024-6
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HE7IL
UT WOS:000453606900002
PM 30558614
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Venturi, ML
   Attinger, CE
   Mesbahi, AN
   Hess, CL
   Graw, KS
AF Venturi, ML
   Attinger, CE
   Mesbahi, AN
   Hess, CL
   Graw, KS
TI Mechanisms and clinical applications of the vacuum-assisted closure
   (VAC) device - A review
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Review
ID SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; NEGATIVE-PRESSURE;
   RANDOMIZED-TRIAL; WOUND CONTROL; THERAPY; MANAGEMENT; SOFT
AB The use of sub-atmospheric pressure dressings, available commercially as the vacuum-assisted closure (VAC) device, has been shown to be an effective way to accelerate healing of various wounds. The optimal sub-atmospheric pressure for wound healing appears to be approximately 125mm Hg utilizing an alternating pressure cycle of 5 minutes of suction followed by 2 minutes off suction. Animal studies have demonstrated that this technique optimizes blood flow, decreases local tissue edema, and removes excessive fluid from the wound bed. These physiologic changes facilitate the removal of bacteria from the wound. Additionally, the cyclical application of sub-atmospheric pressure alters the cytoskeleton of the cells in the wound bed, triggering a cascade of intracellular signals that increases the rate of cell division and subsequent formation of granulation tissue. The combination of these mechanisms makes the VAC device an extremely versatile tool in the armamentarium of wound healing. This is evident in the VAC device's wide range of clinical applications, including treatment of infected surgical wounds, traumatic wounds, pressure ulcers, wounds with exposed bone and hardware, diabetic foot ulcers, and venous stasis ulcers. VAC has also proven useful in reconstruction of wounds by allowing elective planning of the definitive reconstructive surgery without jeopardizing the wound or outcome. Furthermore, VAC has significantly increased the skin graft success rate when used as a bolster over the freshly skin-grafted wound. VAC is generally well tolerated and, with few contraindications or complications, is fast becoming a mainstay of current wound care.
C1 Georgetown Univ Hosp, Limb Ctr, Washington, DC 20007 USA.
C3 Georgetown University
RP Attinger, CE (通讯作者)，Georgetown Univ Hosp, Limb Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM cattinger@aol.com
CR [Anonymous], 2004, WOUNDS, p3S
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NR 41
TC 268
Z9 397
U1 0
U2 57
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PY 2005
VL 6
IS 3
BP 185
EP 194
DI 10.2165/00128071-200506030-00005
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 939AK
UT WOS:000230044300005
PM 15943495
DA 2026-07-24
ER

PT J
AU Pericleous, A
   Dimitrakakis, G
   Photiades, R
   von Oppell, UO
AF Pericleous, Agamemnon
   Dimitrakakis, Georgios
   Photiades, Renos
   von Oppell, Ulrich O.
TI Assessment of vacuum-assisted closure therapy on the wound healing
   process in cardiac surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiac surgery; Risk factors; Sternal wound infection; VAC dressing;
   Wound healing
ID INTERNAL THORACIC ARTERY; POSTSTERNOTOMY MEDIASTINITIS; INFECTION;
   BYPASS; MANAGEMENT; MORTALITY; SKELETONIZATION; PATHOGENESIS;
   STERNOTOMY; GUIDELINES
AB Postoperative deep sternal wound infection (DSWI) is a serious complication in cardiac surgery (1-5% of patients) with high mortality and morbidity rates. Vacuum-assisted closure (VAC) therapy has shown promising results in terms of wound healing process, postoperative hospital length of stay and lower in-hospital costs. The aim of our retrospective study is to report the outcome of patients with DSWI treated with VAC therapy and to assess the effect of contributory risk factors. Data of 52 patients who have been treated with VAC therapy in a single institution (study period: September 2003-March 2012) were collected electronically through PAtient Tracking System PATS and statistically analysed using SPSS version 20. Of the 52 patients (35 M: 17 F), 88<bold></bold>5% (n = 46) were solely treated with VAC therapy and 11<bold></bold>5% (n = 6) had additional plastic surgical intervention. Follow-up was complete (mean 33<bold></bold>8 months) with an overall mortality rate of 26<bold></bold>9% (n = 14) of whom 50% (n = 7) died in hospital. No death was related to VAC complications. Patient outcomes were affected by pre-operative, intra-operative and postoperative risk factors. Logistic EUROscore, postoperative hospital length of stay, advanced age, chronic obstructive pulmonary disease (COPD) and long-term corticosteroid treatment appear to be significant contributing factors in the long-term survival of patients treated with VAC therapy.
C1 [Pericleous, Agamemnon] Cardiff Univ, Sch Med, Cardiff, S Glam, Wales.
   [Pericleous, Agamemnon; Dimitrakakis, Georgios; von Oppell, Ulrich O.] Univ Wales Hosp, Dept Cardiothorac Surg, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.
   [Photiades, Renos] Univ Oxford, Dept Stat, Oxford, England.
C3 Cardiff University; Cardiff University; University of Oxford
RP Dimitrakakis, G (通讯作者)，Univ Wales Hosp, Dept Cardiothorac Surg, Heath Pk, Cardiff CF14 4XW, S Glam, Wales.
EM gdimitrakakis@yahoo.com
OI DIMITRAKAKIS, GEORGIOS/0000-0002-2426-7178
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NR 37
TC 5
Z9 8
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1142
EP 1149
DI 10.1111/iwj.12430
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400007
PM 25728664
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Berdajs, DA
   Trampuz, A
   Ferrari, E
   Ruchat, P
   Hurni, M
   von Segesser, LK
AF Berdajs, Denis A.
   Trampuz, Andrej
   Ferrari, Enrico
   Ruchat, Patrick
   Hurni, Michel
   von Segesser, Ludwig K.
TI Delayed primary versus late secondary wound closure in the treatment of
   postsurgical sternum osteomyelitis
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Surgical site infections; Mediastinitis; Poststernotomy infection;
   Surgical complications
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; RISK-FACTORS; POSTOPERATIVE
   MEDIASTINITIS; SURGERY; INFECTION
AB Sternal osteomyelitis and poststernotomy mediastinitis is a severe and life-threatening complication after the cardiac surgery. The incidence ranges up to 3% with a mortality rate up to 29%. In addition, postoperative infections after sternotomy are associated with prolonged hospital stay, increased healthcare costs and impaired quality of patient life, representing an economic and social burden. The emergence of increasing antimicrobial resistant bacteria augments the importance of postsurgical infections since the antimicrobial choices are becoming limited. Furthermore, the incidence of infection is an indicator for the quality of patient care in the international benchmark studies. Although several therapy strategies are nowadays present in clinical practice, there is a lack of evidence-based surgical consensus for treatment of this surgical complication. In most cases the poststernotomy mediastinitis involves surgical revision with debridement, open dressing and/or vacuum-assisted therapy. After the granulation tissue on open chest wound is achieved, secondary closure andyor reconstruction with vascularized soft tissue flaps, such as omentum or pectoral muscle is performed. It seems there is a need for more effective surgical treatment of poststernotomy wound infections, which may address the prolonged hospitalization and reduce the number of surgical interventions and with this also the perioperative morbidity. In light of this we propose a randomized study comparing new delayed primary closure of the sternum to the secondary vacuum-assisted closure. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Berdajs, Denis A.; Ferrari, Enrico; Ruchat, Patrick; Hurni, Michel; von Segesser, Ludwig K.] CHU Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
   [Trampuz, Andrej] CHU Vaudois, Dept Infect Dis, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Berdajs, DA (通讯作者)，CHU Vaudois, Dept Cardiovasc Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM denis.berdajs@chuv.ch
RI Berdajs, Denis/AAG-8268-2021; /AAD-2897-2020
OI Berdajs, Denis/0000-0003-0478-903X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
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NR 11
TC 15
Z9 18
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2011
VL 12
IS 6
BP 914
EP 918
DI 10.1510/icvts.2010.263483
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022XH
UT WOS:000309997000007
PM 21372144
OA Bronze
DA 2026-07-24
ER

PT J
AU Koenig, V
   Christ, A
   Monai, M
   Andreas, M
   Zimpfer, D
   Happak, W
   Werner, P
AF Koenig, Viktoria
   Christ, Alexandra
   Monai, Maximilian
   Andreas, Martin
   Zimpfer, Daniel
   Happak, Wolfgang
   Werner, Paul
TI When Rewiring Fails-The Enduring Role of the Pectoralis Major Flap in
   Sternal Wound Reconstruction
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE deep sternal wound infection (DSWI); cardiac surgery; pectoralis major
   flap; sternal dehiscence
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS; MEDIAN STERNOTOMY; OMENTAL FLAP;
   RISK-FACTORS; INFECTION; COMPLICATIONS; MEDIASTINITIS; MANAGEMENT
AB Background: Deep sternal wound infections (DSWIs) remain a serious complication after median sternotomy, often requiring complex wound management strategies. While modern approaches include vacuum-assisted closure (VAC) and plating techniques, the pedicled pectoralis major muscle flap (PMF) continues to play a pivotal role in surgical reconstruction, especially in cases with sternal destruction or osteomyelitis. Methods: In this retrospective single-centre analysis, 166 patients with DSWI following cardiac surgery were reviewed. Clinical data, comorbidities, laboratory parameters, and surgical management were evaluated. Logistic regression was performed to assess predictors for reinfection and need for reoperation. Results: Initial wound revision was most frequently performed using sternal rewiring (60.2%), followed by reconstruction with a pectoralis major flap (33.7%). Despite initial surgical treatment, 27.1% of patients developed post-revision wound healing disturbances, and 24.1% ultimately required a second surgical intervention. Among second-time procedures, VAC therapy (32.5%) and PMF reconstruction (20.0%) were the most common approaches. Reinfection was significantly associated with higher preoperative EuroSCOREs (p = 0.044), while initial rewiring carried a higher risk of treatment failure compared to the pectoralis major flap (p = 0.0024). Conclusions: In the setting of sternal destruction or osteomyelitis, the pectoralis major muscle flap remains a fast, effective, and robust solution. Despite its long-standing use, it continues to offer excellent vascularized coverage and infection control in complex DSWI cases.
C1 [Koenig, Viktoria; Christ, Alexandra; Monai, Maximilian; Happak, Wolfgang] Med Univ Vienna, Div Plast, Aesthet & Reconstruct Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Andreas, Martin] Med Univ Graz, Div Cardiac Surg, Neue Stiftingtalstr 6, A-8010 Graz, Austria.
   [Zimpfer, Daniel; Werner, Paul] Med Univ Vienna, Div Cardiac Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Graz; Medical
   University of Vienna
RP Koenig, V (通讯作者)，Med Univ Vienna, Div Plast, Aesthet & Reconstruct Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM viktoria.koenig@meduniwien.ac.at; alexandra.christ@meduniwien.ac.at;
   n11927646@students.meduniwien.ac.at; dr.andreas@me.com;
   daniel.zimpfer@meduniwien.ac.az;
   wolfgang.happak2@wienerneustadt.lknoe.at; paul.werner@meduniwien.ac.at
RI ; Zimpfer, Daniel/AAQ-9805-2021; Christ, Alexandra/LRG-6798-2024
OI Andreas, Martin/0000-0003-4950-5432; Koenig,
   Viktoria/0009-0006-9237-0683; Werner, Paul/0000-0003-0925-6160; Christ,
   Alexandra/0000-0001-6827-4110
CR Allen KB, 2018, ANN THORAC SURG, V105, P1344, DOI 10.1016/j.athoracsur.2017.12.011
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NR 39
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV 26
PY 2025
VL 14
IS 23
AR 8376
DI 10.3390/jcm14238376
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q8536
UT WOS:001635005800001
PM 41375679
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Schibilsky, D
   Benk, C
   Haller, C
   Berchtold-Herz, M
   Siepe, M
   Beyersdorf, F
   Schlensak, C
AF Schibilsky, David
   Benk, Christoph
   Haller, Christoph
   Berchtold-Herz, Michael
   Siepe, Matthias
   Beyersdorf, Friedhelm
   Schlensak, Christian
TI Double tunnel technique for the LVAD driveline: improved management
   regarding driveline infections
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Left ventricular assist device; Driveline; Exit site infection; Double
   tunnel technique; Vacuum-assisted closure therapy
AB A driveline exit site infection is a serious and common complication in long-term left ventricular assist device (LVAD) support. To reduce the incidence and severity of late driveline infections, we modified our surgical technique (double tunnel), and compared it to the conventional short and straight driveline tunnel technique (conventional). We analyzed 43 consecutive patients (37 HeartMate II; 6 Ventrassist) regarding late onset driveline exit site infections after using the surgical driveline tunnel technique after successful LVAD implantation. Of these 43 patients, 11 were treated with the conventional short and straight driveline tunnel technique (conventional), while 32 patients were treated with the modified long subfascial, C-shaped technique (double tunnel). We observed slightly fewer superficial driveline exit site infections in the double tunnel group, even though the difference was not statistically significant (0.638 vs. 1.148 infections/1,000 patient-days; P = 0.22). There were also insignificantly fewer surgical interventions because of exit site infections in the double tunnel group (0.159 vs. 0.581 revisions/1,000 patient-days; P = 0.18). The double tunnel technique offers more surgical options in the case of driveline exit site infections. Due to the long subfascial tunnel, the infected site can be separated from the new driveline exit site, and vacuum-assisted closure therapy can be applied to the infected area. In conclusion, we recommend using the double tunnel driveline technique because of the low infection rate and better treatment options in the case of driveline exit site infection.
C1 [Schibilsky, David; Schlensak, Christian] Univ Med Ctr Tubingen, Dept Thorac & Cardiovasc Surg, D-72076 Tubingen, Germany.
   [Benk, Christoph; Haller, Christoph; Berchtold-Herz, Michael; Siepe, Matthias; Beyersdorf, Friedhelm] Univ Med Ctr Freiburg, Dept Cardiovasc Surg, D-79106 Freiburg, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; University of Freiburg
RP Schibilsky, D (通讯作者)，Univ Med Ctr Tubingen, Dept Thorac & Cardiovasc Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM david.schibilsky@med.uni-tuebingen.de;
   christian.schlensak@med.uni-tuebingen.de
RI Schibilsky, David/AAM-2187-2020; Siepe, Matthias/AAF-9846-2019;
   Beyersdorf, Friedhelm/AAK-3718-2020; Haller, Christoph/IQU-0577-2023
OI Schibilsky, David/0000-0002-7597-7778; Siepe,
   Matthias/0000-0003-3305-9343; Beyersdorf, Friedhelm/0000-0003-2975-2751;
   
CR Al-Hwiesh AK, 2007, SAUDI J KIDNEY DIS T, V18, P37
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NR 8
TC 44
Z9 47
U1 0
U2 3
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PY 2012
VL 15
IS 1
BP 44
EP 48
DI 10.1007/s10047-011-0607-3
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA 921VM
UT WOS:000302506200009
PM 21987183
DA 2026-07-24
ER

PT J
AU Fang, JJ
   Li, PF
   Wu, JJ
   Zhou, HY
   Xie, LP
   Lu, H
AF Fang, Jia-Jie
   Li, Peng-Fei
   Wu, Jia-Jun
   Zhou, Hai-Ying
   Xie, Li-Ping
   Lu, Hui
TI Reconstruction of massive skin avulsion of the scrota and penis by
   combined application of dermal regeneration template (Pelnac) and
   split-thickness skin graft with vacuum-assisted closure: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Artificial dermis; Dermal regeneration template; Massive skin defect;
   Penoscrotal defect; Split-thickness skin graft; Case report
ID COVERAGE; DEFECTS; TRAUMA
AB BACKGROUND Although skin avulsions to male external genitalia are rare, they can be both physically and psychologically traumatic. Thus, the necessity for judicious management poses significant challenges to surgeons in order to avoid potential permanent disabilities. We report a case of massive penoscrotal skin avulsion and a composite graft was creatively applied to cover the defect which achieved good results. We believe that this case is of great reference value for fellow surgeons.
   CASE SUMMARY A 52-year-old male presented with massive traumatic avulsion of the penile and scrotal skin following mishandling of an electric drill. The avulsed skin was missing. The patient was diagnosed with massive skin avulsion of external genitalia. Following initial complete debridement of devitalized or infected tissues, Pelnac dermal substitute was secured to the defect with the assistance of negative-pressure wound closure. In the final step, the silicone layer of Pelnac was removed and a split-thickness skin graft was applied. The defect had healed at the two-month follow-up. The patient now has normal erections and satisfactory sexual function.
   CONCLUSION Our experience with this wound repair demonstrated that the combination of a dermal regeneration template and a split-thickness skin graft with vacuum-assisted closure is a safe, well-tolerated and efficient solution for the reconstruction of massive penoscrotal skin defects.
C1 [Fang, Jia-Jie; Xie, Li-Ping] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Li, Peng-Fei] Zhejiang Univ, Affiliated Hosp 1, Dept Plast & Aesthet Ctr, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wu, Jia-Jun] Xingyan Aesthet Clin, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zhou, Hai-Ying; Lu, Hui] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Orthoped, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Xie, LP (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM xielp@zju.edu.cn
OI lu, hui/0000-0002-5921-1043
FU National Natural Science Foundation of China [81702135]; Zhejiang
   Traditional Chinese Medicine Research Program [2016ZA124, 2017ZB057];
   Zhejiang Medicine and Hygiene Research Program [2016KYB101, 2015KYA100];
   Zhejiang Medical Association Clinical Scientific Research Program
   [2013ZYC-A19, 2015ZYC-A12]
FX Supported by National Natural Science Foundation of China, No. 81702135;
   Zhejiang Traditional Chinese Medicine Research Program, No. 2016ZA124
   and No. 2017ZB057; Zhejiang Medicine and Hygiene Research Program, No.
   2016KYB101 and No. 2015KYA100; Zhejiang Medical Association Clinical
   Scientific Research Program, No. 2013ZYC-A19 and No. 2015ZYC-A12.
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NR 21
TC 11
Z9 11
U1 0
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD DEC 26
PY 2019
VL 7
IS 24
BP 4349
EP 4354
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LO4AS
UT WOS:000533572200021
PM 31911918
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Prokuski, V
   Strohl, A
AF Prokuski, Vanessa
   Strohl, Adam
TI Soft Tissue Coverage for Severe Infections
SO HAND CLINICS
LA English
DT Review
DE Infection; Wound; Coverage; Debridement; Flap
ID HYPERBARIC-OXYGEN THERAPY; UPPER EXTREMITY; RECONSTRUCTIVE LADDER;
   METHICILLIN-RESISTANT; HAND; DEFECTS; FLAPS
AB Coverage of soft tissue defects in the upper extremity caused by infection and debridement of infected tissue is a challenging problem. Treatment starts with prompt identification and eradication of infection, including antibiotics and extensive debridement. Optimizing the patient's medical and nutritional status can facilitate eradication of infection and wound healing. Coverage of soft tissue defects caused by infection and debridement demands consideration of many factors. Options include healing by primary or secondary intention, skin grafts, local flaps, and distant flaps. Negative pressure wound therapy and acellular dermal matrices can also aid in coverage.
C1 [Prokuski, Vanessa] Philadelphia Hand Shoulder Ctr Jefferson, Philadelphia, PA USA.
   [Prokuski, Vanessa] Orthoped Care Phys Network, 675 Paramt Dr,Suite 205, Raynham, MA 02767 USA.
   [Strohl, Adam] Thomas Jefferson Univ Hosp, Plast & Reconstruct Surg, Philadelphia Hand Shoulder Ctr, 834 Chestnut St,Suite G-114, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University
RP Strohl, A (通讯作者)，Thomas Jefferson Univ Hosp, Plast & Reconstruct Surg, Philadelphia Hand Shoulder Ctr, 834 Chestnut St,Suite G-114, Philadelphia, PA 19107 USA.
EM ABStrohl@handcenters.com
RI Strohl, Adam/NLN-7045-2025
OI Strohl, Adam/0000-0001-5671-9776
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   Woon CYL, 2007, PLAST RECONSTR SURG, V120, P1922, DOI 10.1097/01.prs.0000287284.40627.a6
   YAREMCHUK MJ, 1987, PLAST RECONSTR SURG, V80, P1
NR 46
TC 4
Z9 9
U1 0
U2 34
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0712
EI 1558-1969
J9 HAND CLIN
JI Hand Clin.
PD AUG
PY 2020
VL 36
IS 3
BP 369
EP +
DI 10.1016/j.hcl.2020.03.011
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA MC5ZB
UT WOS:000543363600013
PM 32586464
DA 2026-07-24
ER

PT J
AU Danks, RR
   Lairet, K
AF Danks, Roy R.
   Lairet, Kimberly
TI Innovations in Caring for a Large Burn in the Iraq War Zone
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VIENNESE CONCEPT; MEEK
AB The authors report on a single case of a large, civilian burn cared for at a U.S. military hospital during Operation Iraqi Freedom. The management of the patient, using a large negative pressure wound therapy device and the Meek grafting technique, is reviewed. This is a case report. The patient survived his injury. In Iraq, most patients with this severity of injury succumb to the injury. By using two innovative techniques, the authors found that the patient was able to survive his injury and return to his home. (J Burn Care Res 2010; 31: 665-669)
C1 [Danks, Roy R.; Lairet, Kimberly] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA.
RP Danks, RR (通讯作者)，1001 6th Ave,Ste 230, Leavenworth, KS 66048 USA.
CR *AM BURN ASS, NAT BURN REP 2008 RE
   BERGMANN J, 2009, J BURN CARE RES S, V29, pS58
   Lumenta DB, 2009, J BURN CARE RES, V30, P231, DOI 10.1097/BCR.0b013e318198a2d6
   MEEK CP, 1958, AM J SURG, V96, P557, DOI 10.1016/0002-9610(58)90975-9
   Roka J, 2007, HANDCHIR MIKROCHIR P, V39, P322, DOI 10.1055/s-2007-965324
NR 5
TC 20
Z9 21
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2010
VL 31
IS 4
BP 665
EP 669
DI 10.1097/BCR.0b013e3181e4c8aa
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 622DC
UT WOS:000279638400020
PM 20523231
DA 2026-07-24
ER

PT J
AU Takahashi, Y
   Sasaki, Y
   Bito, Y
   Motoki, M
   Murakami, T
   Shibata, T
AF Takahashi, Yosuke
   Sasaki, Yasuyuki
   Bito, Yasuyuki
   Motoki, Manabu
   Murakami, Takashi
   Shibata, Toshihiko
TI Perigraft fluid collection mimicking graft infection in patients with a
   para-anastomotic aneurysm
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID SAC ENLARGEMENT; ENDOTENSION; CLASSIFICATION; REPAIR
AB We herein report two cases of perigraft effusion mimicking graft infection after debranching thoracic endovascular repair for an anastomotic pseudoaneurysm of the distal ascending aorta. Both patients presented with a bulging tumor on the sternum. Enhanced computed tomography showed no endoleak, but extension of periprosthetic graft fluid to a subcutaneous sternal wound was present. We suspected a deep sternal wound infection; however, cultures of debrided tissues were negative. After drainage of the subcutaneous fluid or negative pressure wound therapy, both patients were doing well without recurrence of effusion. Endotension was considered to have been associated with enlargement of the perigraft effusion.
C1 [Takahashi, Yosuke; Sasaki, Yasuyuki; Bito, Yasuyuki; Motoki, Manabu] Osaka City Gen Hosp, Div Cardiovasc Surg, Osaka, Japan.
   [Murakami, Takashi; Shibata, Toshihiko] Osaka City Univ, Grad Sch Med, Dept Cardiovasc Surg, Osaka, Japan.
C3 Osaka City General Hospital; Osaka Metropolitan University
RP Takahashi, Y (通讯作者)，Osaka City Gen Hosp, Dept Cardiovasc Surg, Miyakojima Ku, 2-13-22 Hondori Miyakojima, Osaka 5340021, Japan.
EM ysk@msic.med.osaka-cu.ac.jp
RI Takahashi, Yosuke/GPC-5174-2022; /AAH-8028-2019; Shibata,
   Toshihiko/ISB-3776-2023
OI Takahashi, Yosuke/0000-0003-2258-7204; 
CR Cerna M, 2009, J VASC SURG, V50, P648, DOI 10.1016/j.jvs.2009.04.044
   Gilling-Smith G, 1999, J ENDOVASC SURG, V6, P305, DOI 10.1583/1074-6218(1999)006<0305:EAEARD>2.0.CO;2
   Kougias P, 2007, J VASC SURG, V46, P124, DOI 10.1016/j.jvs.2007.02.067
   Mennander A, 2005, J VASC SURG, V42, P194, DOI 10.1016/j.jvs.2005.02.050
   Smith ST, 2007, J VASC SURG, V45, P395, DOI 10.1016/j.jvs.2006.08.077
   Ten Bosch JA, 2011, J VASC SURG, V54, P1571, DOI 10.1016/j.jvs.2011.04.072
   White GH, 1997, J ENDOVASC SURG, V4, P152, DOI 10.1583/1074-6218(1997)004<0152:EAACOE>2.0.CO;2
NR 7
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2017
VL 65
IS 4
BP 1189
EP 1191
DI 10.1016/j.jvs.2016.07.124
PG 3
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA EW6MT
UT WOS:000402625400037
PM 27751737
DA 2026-07-24
ER

PT J
AU Diefenbeck, M
   Haustedt, N
   Schmidt, HGK
AF Diefenbeck, Michael
   Haustedt, Nils
   Schmidt, Hergo G. K.
TI Surgical debridement to optimise wound conditions and healing
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Debridement; Osteomyelitis; Skin and soft tissue infection
ID OSTEOMYELITIS
AB Different treatment strategies are available for bone, joint and soft tissue infections, including use of local antibiotics; negative pressure wound therapy; one-stage, two-stage or multi-stage revisions; or open wound therapy. All methods have one principle in common: adequate surgical debridement is the prerequisite for successful treatment of bone, joint and soft tissue infections. According to the different textures of healthy, infected or necrotic tissue, special techniques are used. In this article we will describe the clinical presentation of necrotic and non-vital tissue in skin, soft tissue and bone and appropriate techniques of debridement.
C1 [Diefenbeck, Michael; Haustedt, Nils; Schmidt, Hergo G. K.] Schon Klin Hamburg Eilbek, D-22081 Hamburg, Germany.
RP Diefenbeck, M (通讯作者)，Schon Klin Hamburg Eilbek, Dehnhaide 120, D-22081 Hamburg, Germany.
EM MDiefenbeck@schoen-kliniken.de
FU Kinetic Concepts, Inc. (KCI); KCI
FX MD presented as a faculty member during the 2012 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by Kinetic
   Concepts, Inc. (KCI). His article is part of a KCI-funded educational
   supplement based on faculty presentations at 2012 and 2013 ISWF sessions
   related to wound care strategies with a focus on use of Negative
   Pressure Wound Therapy with instillation (i.e. V.A.C. Instill (R) Wound
   Therapy and V.A.C. VeraFlo (TM) Therapy, KCI, San Antonio, TX). KCI
   assisted with editorial review of manuscript. NH and HGKS state no
   conflict of interests or financial relationship with KCI.
CR [Anonymous], TRAUMA BERUFSKRANKH
   Buhler M, 2003, ATLAS UNFALLCHIRURGE
   Cierny G, 2003, CLIN ORTHOP RELAT R, P7, DOI 10.1097/01.blo.0000088564.81746.62
   ECKARDT JJ, 1994, CLIN ORTHOP RELAT R, P229
   ILIZAROV GA, 1988, B HOSP JOINT DIS ORT, V48, P1
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   Lew DP, 2004, LANCET, V364, P369, DOI 10.1016/S0140-6736(04)16727-5
   Sachs BL, 1983, 50 ANN M AAOS AN CAL
   VOROS D, 1993, BRIT J SURG, V80, P1190, DOI 10.1002/bjs.1800800943
NR 9
TC 21
Z9 27
U1 1
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 43
EP 47
DI 10.1111/iwj.12187
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300008
PM 24251843
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Wu, CQ
   Jin, ZX
   Yang, YM
AF Wu, Chunqiao
   Jin, Zhexia
   Yang, Yongmei
TI A large forearm subcutaneous hematoma after contrast extravasation
   requires surgical managements: A case report
SO MEDICINE
LA English
DT Article
DE case report; computed tomography; contrast extravasation; debridement;
   hematoma; nursing care
AB Rationale: Large extremity hematoma can rarely happen after contrast extravasation during a contrast-enhanced computed tomography scan. Some hematomas need prompt surgical managements. Patient concerns: A 77-year-old man had acute ischemic stroke and received the thrombolytic and antiplatelet therapies. He had a contrast extravasation during the computed tomography scan and developed a large hematoma in the right forearm, despite without evidence of compartment syndrome. Diagnosis: Right forearm hematoma, status post contrast extravasation. Interventions: The patient responded poorly to the routine care with arm elevation, cold pack, and wet dressing, and was finally treated by the surgical debridement, vacuum sealing drainage, fascioplasty, and skin flap repair. Outcomes: Right forearm wound healed with a scar. Lessons: Large extremity hematoma can happen after contrast extravasation during computed tomography scan, which may require surgical treatments. Careful preparation, close monitor, and prompt managements should be applied in high-risk patients.
C1 [Wu, Chunqiao; Jin, Zhexia; Yang, Yongmei] Zhejiang Univ, Sir Run Run Show Hosp, Sch Med, Hangzhou, Peoples R China.
C3 Zhejiang University
RP Wu, CQ (通讯作者)，Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Peoples R China.
EM 13747256@qq.com; jingzhexia@163.com; jamin911@126.com
CR Beecham G B., 2022, StatPearls
   Belzunegui T, 2011, SCAND J TRAUMA RESUS, V19, DOI 10.1186/1757-7241-19-9
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   D'Asero G, 2010, EUR REV MED PHARMACO, V14, P643
   Gong ZH, 2021, RISK MANAG HEALTHC P, V14, P4931, DOI 10.2147/RMHP.S318832
   Kim JT, 2020, J EDUC EVAL HEALTH P, V17, DOI 10.3352/jeehp.2020.17.21
   Papatheodorou N, 2022, J SURG CASE REP, V2022, DOI 10.1093/jscr/rjac054
   Roditi G, 2022, EUR RADIOL, V32, P3056, DOI 10.1007/s00330-021-08433-4
   Stavrakakis IM, 2018, OXF MED CASE REP, P425, DOI 10.1093/omcr/omy098
   Yurdakul E, 2014, AM J EMERG MED, V32, DOI 10.1016/j.ajem.2014.02.042
NR 10
TC 2
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 6
PY 2024
VL 103
IS 36
AR e39536
DI 10.1097/MD.0000000000039536
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F2I0Q
UT WOS:001308095200083
PM 39252279
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Achora, S
   Muliira, JK
   Thanka, AN
AF Achora, Susan
   Muliira, Joshua Kanaabi
   Thanka, Anita Nesa
TI Strategies to Promote Healing of Split Thickness Skin Grafts: An
   Integrative Review
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Review
DE dressings; evidence-based practice; fixation; nursing care; split
   thickness skin graft; wound care
ID WOUNDS; THERAPY; HEAD
AB Skin grafts are commonly used to promote healing of shallow wounds and burns, and wound care nurses play an important role in management of wounds treated with grafting. The purpose of this article was to review recent findings regarding strategies to promote healing of split-thickness skin grafts including topical phenytoin or platelet-rich plasma prior to graft application, fibrin sealant, or negative pressure wound therapy to stabilize a graft and to promote close adherence of the graft to the underlying wound bed and adjunctive therapies such as laser.
C1 [Achora, Susan; Muliira, Joshua Kanaabi; Thanka, Anita Nesa] Sultan Qaboos Univ, Dept Adult Hlth & Crit Care, Coll Nursing, Muscat, Oman.
C3 Sultan Qaboos University
RP Achora, S (通讯作者)，Sultan Qaboos Univ, Coll Nursing, POB 66, Al Khoud Muscat, Oman.
EM susanachora@ymail.com
RI MULIIRA, JOSHUA/ABC-7480-2020
OI MULIIRA, JOSHUA/0000-0003-3091-8835
CR Adams DC, 2005, DERMATOL SURG, V31, P1055
   Akita S, 2010, WOUND REPAIR REGEN, V18, P560, DOI 10.1111/j.1524-475X.2010.00620.x
   Al-Mutairi N, 2010, DERMATOL SURG, V36, P499, DOI 10.1111/j.1524-4725.2010.01477.x
   Anderson JJ, 2012, DIABET FOOT ANKLE, V3
   Andreassi A, 2005, CLIN DERMATOL, V23, P332, DOI 10.1016/j.clindermatol.2004.07.024
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   Blume PA, 2010, INT WOUND J, V7, P480, DOI 10.1111/j.1742-481X.2010.00728.x
   Chen TM, 2010, DERMATOL SURG, V36, P453, DOI 10.1111/j.1524-4725.2010.01480.x
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NR 32
TC 17
Z9 19
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2014
VL 41
IS 4
BP 335
EP 339
DI 10.1097/WON.0000000000000035
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AK8WV
UT WOS:000338710300007
PM 24988511
DA 2026-07-24
ER

PT J
AU Li, RY
   Xiang, L
   Lu, JH
   Chen, LZ
   Cai, XS
AF Li, Ruiying
   Xiang, Lei
   Lu, Jinghui
   Chen, Linzhen
   Cai, Xiangsheng
TI First Chinese case report of Helcococcus kunzii in a patient with
   diabetic foot
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Helcococcus kunzii; Diabetic foot; MALDI-TOF-MS; 16S rRNA gene
   sequencing; Case report
ID SP NOV.
AB BackgroundInfection of Helcococcus kunzii(H. kunzii) from diabetic foot wound is rarely reported. This case report describes the infection of H.kunzii and highlights the therapeutic effect on H.kunzii from a diabetic foot wound.Case presentationIn this study, one H. kunzii strain was isolated from a patient with diabetic foot, which was confirmed by 16S rRNA gene analysis and MALDI-TOF-MS. It is the first Chinese case of H. kunzii in a patient with diabetic foot. As a result of the lack of antibiotic sensitivity data and multiple comorbidities, antibiotics were used cautiously, and those administered during the first 3months were ineffective. Then, vacuum sealing drainage (VSD) was applied during hospitalization; no antibiotics were used and the wound healed well.ConclusionsVSD alone may be more effective in treating diabetic feet infected with H. kunzii, which may provide reference for clinical treatment of H. kunzii infection from diabetic foot.
C1 [Li, Ruiying; Lu, Jinghui; Chen, Linzhen] Guangdong Pharmaceut Univ, Clin Lab, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Xiang, Lei; Cai, Xiangsheng] Univ Chinese Acad Sci, Ctr Med Expt, Shenzhen Hosp, Shenzhen, Peoples R China.
C3 Guangdong Pharmaceutical University; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Cai, XS (通讯作者)，Univ Chinese Acad Sci, Ctr Med Expt, Shenzhen Hosp, Shenzhen, Peoples R China.
EM xiangshengcai@yeah.net
RI Cai, Xiangsheng/GPS-8610-2022
OI Cai, Xiangsheng/0000-0002-6353-8188
FU National Natural Science Foundation of China [81804030]
FX This research was supported by the National Natural Science Foundation
   of China (grant no. 81804030). The funders had no role in study design,
   data collection and analysis, decision on publish, or preparation of the
   manuscript.
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NR 9
TC 1
Z9 1
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUL 20
PY 2021
VL 21
IS 1
AR 695
DI 10.1186/s12879-021-06309-y
PG 4
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA TP3RN
UT WOS:000677511300001
PM 34284730
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bluman, EM
   Ficke, JR
   Covey, DC
AF Bluman, Eric M.
   Ficke, James R.
   Covey, Dana C.
TI War Wounds of the Foot and Ankle: Causes, Characteristics, and Initial
   Management
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Battlefield injuries; Explosive weaponry; Lower extremity injuries;
   Negative pressure wound therapy
ID RED-CROSS; TRAUMATIC AMPUTATION; LEAD-INTOXICATION; BLAST INJURIES;
   TECHNIQUE TIP; BALLISTICS; CLASSIFICATION; RESUSCITATION; EXPLOSIONS;
   TERRORISM
AB There are many challenges inherent in caring for battlefield injuries to the foot and ankle. Optimal treatment for these injuries continues to change overtime. Newer techniques in the management of massive soft tissue and bony wounds will help to restore the best possible function. These include early damage control surgery, modern limb salvage techniques, and SAWD. The current wars in Iraq and Afghanistan will continue to provide a stimulus for advances in the treatment of high-energy, complex musculoskeletal trauma.
C1 [Bluman, Eric M.] Brigham & Womens Hosp, Dept Orthoped, Foot & Ankle Serv, Boston, MA 02115 USA.
   [Bluman, Eric M.] Harvard Univ, Sch Med, Boston, MA USA.
   [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
   [Covey, Dana C.] USN, Med Ctr, Dept Orthopaed Surg, San Diego, CA 92134 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School; Brooke
   Army Medical Center; United States Department of Defense; United States
   Army; United States Department of Defense; United States Navy
RP Bluman, EM (通讯作者)，Brigham Foot & Ankle Ctr Faulkner, 1153 Ctr St,Suite 56, Boston, MA 02130 USA.
EM ebluman@partners.org
RI Bluman, Eric M/K-5849-2019
OI Bluman, Eric M/0000-0002-3848-1677; Covey, Dana/0000-0002-4023-6304
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NR 51
TC 20
Z9 28
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
EI 1558-1934
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD MAR
PY 2010
VL 15
IS 1
BP 1
EP 21
DI 10.1016/j.fcl.2009.11.004
PG 21
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 745TK
UT WOS:000289189200002
PM 20189114
DA 2026-07-24
ER

PT J
AU Miranda, LEC
   Miranda, ACG
AF Miranda, Luiz E. C.
   Miranda, Ana C. G.
TI Enteroatmospheric fistula management by endoscopic gastrostomy PEG tube
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal sepsis; Negative pressure wound therapy; Open abdomen;
   Small-bowel fistula; Temporary abdominal closure
AB Management of small-bowel fistulas which are in an open abdomen and have no soft tissue overlay or a fistula tract involves many complications and challenges. Controlling the local leakage of enteric contents has a central role in the success of medical treatment. There are several methods to deal with fistula discharge but unfortunately, the technical solutions only partially address such problems and a definitive management of fistula discharge still remains an insoluble challenge. We describe a simple and cheap method to control fistula leakage by using a percutaneous endoscopic gastrostomy tube.
C1 [Miranda, Luiz E. C.; Miranda, Ana C. G.] Univ Pernambuco, Oswaldo Cruz Hosp, Dept Gen Surg, Rua Arnobio Marques 310, BR-51100130 Recife, PE, Brazil.
C3 Universidade de Pernambuco (UPE)
RP Miranda, LEC (通讯作者)，Univ Pernambuco, Oswaldo Cruz Hosp, Dept Gen Surg, Rua Arnobio Marques 310, BR-51100130 Recife, PE, Brazil.
EM lecmiranda@gmail.com
RI /C-1450-2017
CR Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Di Saverio S, 2011, J TRAUMA, V71, P760, DOI 10.1097/TA.0b013e318216e340
   Majercik S, 2012, NUTR CLIN PRACT, V27, P507, DOI 10.1177/0884533612444541
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   Ozer MT, 2014, INT WOUND J, V11, P22, DOI 10.1111/iwj.12308
   Terzi C, 2014, INT WOUND J, V11, P17, DOI 10.1111/iwj.12288
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   Yin JY, 2014, NUTR CLIN PRACT, V29, P656, DOI 10.1177/0884533614536587
NR 8
TC 6
Z9 9
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 915
EP 917
DI 10.1111/iwj.12726
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400004
PM 28198100
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cook, R
   Thomas, V
   Martin, R
AF Cook, Rob
   Thomas, Vaughan
   Martin, Rosie
CA NIHR Dissemination Ctr
TI Negative pressure dressings are no better than standard dressings for
   open fractures
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Editorial Material
AB The study Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb: the WOLLF randomised clinical trial. Costa ML, Achten J, Bruce J, et al; UK WOLLF Collaboration Published on 9 October 2018 JAMA 2018;319:2280-8. This project was funded by the National Institute for Health Research Health Technology Assessment Programme ( project number 10/57/20). To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000655/negative-pressure-dressings-are-no-better-than-standard-dressings-for-open-fractures
C1 [Cook, Rob; Martin, Rosie] Bazian, Economist Intelligence Unit Healthcare, London, England.
   [Thomas, Vaughan] Univ Southampton, Wessex Inst, Southampton, Hants, England.
C3 University of Southampton
RP Cook, R (通讯作者)，Bazian, Economist Intelligence Unit Healthcare, London, England.
EM rob.cook@bazian.com
OI Cook, Robert/0000-0002-2210-3989
FU National Institute for Health Research [10/57/20] Funding Source:
   researchfish
CR Iheozor-Ejiofor Z, 2018, COCHRANE DB SYST REV, V7
   National Institute for Health and Care Excellence, FRACT COMPL ASS MAN
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
NR 3
TC 4
Z9 6
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD MAR 13
PY 2019
VL 364
AR k4411
DI 10.1136/bmj.k4411
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HP5VW
UT WOS:000461751600019
PM 30867157
DA 2026-07-24
ER

PT J
AU Vickery, K
AF Vickery, Karen
TI Special Issue: Microbial Biofilms in Healthcare: Formation, Prevention
   and Treatment
SO MATERIALS
LA English
DT Editorial Material
DE biofilms; dry surface biofilms; periodontitis; breast implants; Candida
   auris; calcium sulphate; antibiotic; topical negative pressure wound
   therapy; antimicrobial peptides
AB Biofilms are a structured community of microorganisms that are attached to a surface. Individual bacteria are embedded in a bacterial-secreted matrix. Biofilms have significantly increased tolerance to removal by cleaning agents and killing by disinfectants and antibiotics. This special issue is devoted to diagnosis and treatment of biofilm-related diseases in man. It highlights the differences between the biofilm and planktonic (single cell) lifestyles and the diseases biofilms cause from periodontitis to breast implant capsular contracture. Biofilm-specific treatment options are detailed in experimental and review manuscripts.
C1 [Vickery, Karen] Macquarie Univ, Surg Infect Res Grp, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia.
C3 Macquarie University
RP Vickery, K (通讯作者)，Macquarie Univ, Surg Infect Res Grp, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia.
EM karen.vickery@mq.edu.au
OI Vickery, Karen/0000-0003-0998-1370
CR Almatroudi A, 2016, J HOSP INFECT, V93, P263, DOI 10.1016/j.jhin.2016.03.020
   Beitelshees M, 2018, MATERIALS, V11, DOI 10.3390/ma11071086
   Costa DM, 2019, LETT APPL MICROBIOL, V68, P269, DOI 10.1111/lam.13127
   Hu H, 2015, J HOSP INFECT, V91, P35, DOI 10.1016/j.jhin.2015.05.016
   Johani K, 2018, J INFECT PUBLIC HEAL, V11, P418, DOI 10.1016/j.jiph.2017.10.005
   Kamaruzzaman NF, 2018, MATERIALS, V11, DOI 10.3390/ma11091705
   Lasserre JF, 2018, MATERIALS, V11, DOI 10.3390/ma11101802
   Laycock PA, 2018, MATERIALS, V11, DOI 10.3390/ma11112265
   Ledwoch K, 2018, J HOSP INFECT, V100, pE47, DOI 10.1016/j.jhin.2018.06.028
   Ledwoch K, 2019, MATERIALS, V12, DOI 10.3390/ma12010018
   Mempin M, 2018, MATERIALS, V11, DOI 10.3390/ma11122393
   Subhadra B, 2018, MATERIALS, V11, DOI 10.3390/ma11091676
   Tahir S, 2018, MATERIALS, V11, DOI 10.3390/ma11050811
   Yasir M, 2018, MATERIALS, V11, DOI 10.3390/ma11122468
NR 14
TC 30
Z9 37
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1996-1944
J9 MATERIALS
JI Materials
PD JUN 2
PY 2019
VL 12
IS 12
AR 2001
DI 10.3390/ma12122001
PG 3
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
   Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering;
   Physics
GA IG4FL
UT WOS:000473759400120
PM 31234513
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Balsa, IM
   Culp, WTN
AF Balsa, Ingrid M.
   Culp, William T. N.
TI Wound Care
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Wound management; Wound healing; Bandage; Dressing
ID SMALL-INTESTINAL SUBMUCOSA; THICKNESS SKIN WOUNDS; SUCTION DRAINS;
   THERAPY; INFECTIONS; DOGS; FIBROBLASTS; IRRIGATION
AB Wound care requires an understanding of normal wound healing, causes of delays of wound healing, and the management of wounds. Every wound must be treated as an individual with regard to cause, chronicity, location, and level of microbial contamination, as well as patient factors that affect wound healing. Knowledge of wound care products available and when negative pressure wound therapy and drain placement is appropriate can improve outcomes with wound healing. Inappropriate product use can cause delays in healing. As a wound healing progresses, management of a wound and the bandage material used must evolve.
C1 [Balsa, Ingrid M.; Culp, William T. N.] Univ Calif Davis, Dept Surg & Radiol Sci, Davis, CA 95616 USA.
C3 University of California System; University of California Davis
RP Culp, WTN (通讯作者)，Univ Calif Davis, Dept Surg & Radiol Sci, One Shields Dr, Davis, CA 95616 USA.
EM wculp@ucdavis.edu
OI Balsa, Ingrid/0000-0002-1824-5896; Culp, William/0000-0001-6132-156X
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NR 55
TC 53
Z9 64
U1 1
U2 78
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD SEP
PY 2015
VL 45
IS 5
BP 1049
EP +
DI 10.1016/j.cvsm.2015.04.009
PG 19
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CR8EH
UT WOS:000361583400012
PM 26022525
DA 2026-07-24
ER

PT J
AU Yang, XF
   Aihemaiti, M
   Zhang, H
   Jiang, L
   Zhang, GX
   Qin, ML
   Pan, YH
   Wen, XM
   Chan, FSY
   Fan, JKM
AF Yang, Xuefei
   Aihemaiti, Maimaiti
   Zhang, Hao
   Jiang, Li
   Zhang, Guixi
   Qin, Mali
   Pan, Yiheng
   Wen, Xiumei
   Chan, Fion Siu Yin
   Fan, Joe King Man
TI Mesh-preservation approach to treatment of mesh infection after large
   incisional ventral hernia repair-how I do it
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Large incisional hernia; mesh infection; mesh-preservation
ID SURGERY
AB Mesh infection after large incisional ventral hernia repair is a clinical dilemma in abdominal wall hernia surgery. It is believed foreign material should be removed but it causes secondary trauma to the abdominal wall tissue and might be associated with a higher risk of complications. Currently, there is no consensus on mesh-preservation treatment in cases of mesh infection after hernia repair in general. Herein we present the case of a 27-year-old male who recovered well from mesh infection after large incisional ventral hernia repair by mesh-preservation approach. The path to success is choice of material of prosthetic mesh; surgical approach of hernia repair, sufficient wound irrigation and drainage, and acquiring sterility of the mesh surface by wound care techniques such as local iodophor packing and vacuum sealing drainage. Clinical cohorts are needed to verify the feasibility of mesh-preservation treatment of mesh infection after large incisional hernia repair.
C1 [Yang, Xuefei; Aihemaiti, Maimaiti; Zhang, Hao; Jiang, Li; Zhang, Guixi; Qin, Mali; Pan, Yiheng; Wen, Xiumei; Chan, Fion Siu Yin; Fan, Joe King Man] Univ Hong Kong, Shenzhen Hosp, Dept Surg, 1 Haiyuan 1st Rd, Shenzhen 518053, Guangdong, Peoples R China.
   [Chan, Fion Siu Yin; Fan, Joe King Man] Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Fan, JKM (通讯作者)，Univ Hong Kong, Shenzhen Hosp, Dept Surg, 1 Haiyuan 1st Rd, Shenzhen 518053, Guangdong, Peoples R China.
EM drjoefan@hku.hk
CR Bikhchandani Jai, 2013, Adv Surg, V47, P1
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NR 11
TC 4
Z9 7
U1 0
U2 6
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD NOV
PY 2019
VL 7
IS 22
AR 698
DI 10.21037/atm.2019.10.82
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA JS7BX
UT WOS:000500459400088
PM 31930099
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Aulisa, AG
   Marsiolo, M
   Basiglini, L
   Aletto, C
   Giordano, M
   Falciglia, F
AF Aulisa, Angelo Gabriele
   Marsiolo, Martina
   Basiglini, Luca
   Aletto, Cristian
   Giordano, Marco
   Falciglia, Francesco
TI Management of Open Pediatric Fractures: Proposal of a New
   Multidisciplinary Algorithm
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE open pediatric fracture; management of open fractures; multidisciplinary
   algorithm; exposed fractures; children's fractures
ID I OPEN FRACTURES; VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES;
   NONOPERATIVE MANAGEMENT; SOFT-TISSUE; CHILDREN; BONE; POPULATION;
   EXPERIENCE
AB Background: An algorithm for managing open fractures in children is still being debated; the present study suggests an evidence-based way to manage these patients in the emergency department. Methods: The literature on "Open fractures in children" was carefully analyzed using keywords. The primary sources were The Cochrane Library, PubMed, and Researchgate. Conclusion: We proposed an evidence-based algorithm for managing open fractures in children to standardize clinical practice and improve the care of these patients.
C1 [Aulisa, Angelo Gabriele; Marsiolo, Martina; Basiglini, Luca; Giordano, Marco; Falciglia, Francesco] Bambino Gesu Pediat Hosp, UOC Orthopaed & Traumatol, IRCCS, I-00165 Rome, Italy.
   [Aulisa, Angelo Gabriele] Univ Cassino & Southern Lazio, Dept Human Sci Soc & Hlth, I-03043 Cassino, Italy.
   [Aletto, Cristian] Univ Salerno, Fac Med & Surg, Dept Musculoskeletal Disorders, I-84084 Baronissi, Italy.
C3 IRCCS Bambino Gesu; University of Cassino; University of Salerno
RP Marsiolo, M (通讯作者)，Bambino Gesu Pediat Hosp, UOC Orthopaed & Traumatol, IRCCS, I-00165 Rome, Italy.
EM agabriele.aulisa@opbg.net; Martina.marsiolo@opbg.net;
   luca.basiglini@opbg.net; cris.aletto28@gmail.com;
   marco.giordano@opbg.net; francesco.falciglia@opbg.net
RI Aulisa, Angelo Gabriele/AAH-9244-2019; Basiglini, Luca/AAA-7583-2020;
   Falciglia, Francesco/AAI-2543-2019; giordano, marco/AAH-9404-2019
OI Aulisa, Angelo Gabriele/0000-0003-2917-9385; Basiglini,
   Luca/0000-0003-4057-9371; giordano, marco/0000-0002-9646-8892
FU Italian Ministry of Health
FX This work was supported also by the Italian Ministry of Health with
   "Current Research funds". No benefits in any form have been or will be
   received from a commercial party related directly or indirectly to the
   subject of this manuscript. The manuscript submitted does not contain
   information about medical device(s)/drug(s).
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NR 39
TC 6
Z9 6
U1 2
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2023
VL 12
IS 19
AR 6378
DI 10.3390/jcm12196378
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X3CF6
UT WOS:001097259600001
PM 37835023
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Herscu, G
   Wilson, SE
AF Herscu, Gabriel
   Wilson, Samuel Eric
TI Prosthetic Infection: Lessons from Treatment of the Infected Vascular
   Graft
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Vascular; Prosthesis; Graft; Infection
ID VACUUM ASSISTED CLOSURE; IN-SITU REVASCULARIZATION; ARTERIAL
   RECONSTRUCTION; AORTIC-ANEURYSM; SURGICAL SITE; MANAGEMENT;
   METAANALYSIS; PRESERVATION; HEMODIALYSIS; PREVENTION
AB Surgical prosthetics provide unquestioned benefit to patients in maintenance of life and limb. However, complications associated with prosthetic devices continue to represent a significant source of morbidity and mortality. Even as the surgeon becomes more adept at management of infections, the bacterial characteristics change in favor of increased virulence and greater resistance to antimicrobials. Excision or retention of the prosthesis depends on the time of presentation, the microbial isolates recovered, and the extent of surrounding tissue destruction. Recent work shows improving results with in situ replacement.
C1 [Herscu, Gabriel; Wilson, Samuel Eric] Univ Calif Irvine, Med Ctr, Dept Surg, Orange, CA 92868 USA.
C3 University of California System; University of California Irvine
RP Herscu, G (通讯作者)，Univ Calif Irvine, Med Ctr, Dept Surg, 333 City Blvd W,Suite 705, Orange, CA 92868 USA.
EM gherscu@uci.edu
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NR 48
TC 39
Z9 40
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD APR
PY 2009
VL 89
IS 2
BP 391
EP +
DI 10.1016/j.suc.2008.09.007
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 433DF
UT WOS:000265183800008
PM 19281890
DA 2026-07-24
ER

PT J
AU Heimroth, J
   Chen, E
   Sutton, E
AF Heimroth, Jamie
   Chen, Eric
   Sutton, Erica
TI Management Approaches for Enterocutaneous Fistulas
SO AMERICAN SURGEON
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; ABDOMINAL-WALL; INTESTINAL
   TRANSPLANTATION; NUTRITIONAL SUPPORT; GASTROINTESTINAL FISTULAS;
   ENTEROATMOSPHERIC FISTULA; SURGICAL REPAIR; WOUND CLOSURE; SEVERE SEPSIS
AB There are very few clinical studies that highlight a definitive and comprehensive guideline for the management of enterocutaneous fistulas. Most accepted guidelines are found in textbooks and are taken from expert advice and case reports. The goal of this review is to highlight advancements relevant to the management of enterocutaneous fistulas from the recent two to three years. Although strong evidence-based guidelines are lacking, the consensus is that a multidisciplinary team working with a clear treatment plan targeting multiple aspects of management can maximize patient outcomes.
C1 [Heimroth, Jamie; Sutton, Erica] Univ Louisville, Dept Surg, 550 South Jackson St, Louisville, KY 40202 USA.
   [Chen, Eric] Univ Nebraska Med Ctr, Dept Neurosurg, Omaha, NE USA.
C3 University of Louisville; University of Nebraska System; University of
   Nebraska Medical Center
RP Sutton, E (通讯作者)，Univ Louisville, Dept Surg, 550 South Jackson St, Louisville, KY 40202 USA.; Sutton, E (通讯作者)，Univ Louisville, Surg Simulat, 550 South Jackson St, Louisville, KY 40202 USA.
EM Erica.sutton@louisville.edu
OI Chen, Eric/0000-0002-5853-2558
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NR 62
TC 20
Z9 26
U1 0
U2 7
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAR
PY 2018
VL 84
IS 3
BP 326
EP 333
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GB0FH
UT WOS:000428720300013
PM 29559044
DA 2026-07-24
ER

PT J
AU Evenson, AR
   Fischer, JE
AF Evenson, AR
   Fischer, JE
TI Current management of enterocutaneous fistula
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE enterocutaneous fistula; sepsis; nutrition
ID VACUUM-ASSISTED CLOSURE; GASTROINTESTINAL FISTULAS; EXTERNAL FISTULAS;
   SMALL-BOWEL; OCTREOTIDE; SOMATOSTATIN; INFLIXIMAB
AB Enterocutaneous fistulas, defined as abnormal communications between bowel and skin, are among the most challenging conditions managed by the general surgeon. In an era when the mortality from pancreaticoduodenectoiny is less than 3%, the mortality of enterocutaneous fistulas remains 10 to 30% due to the often-present complications of sepsis, malnutrition, and electrolyte abnormalities. Taking advantage of recent advances in techniques of pre- and post-surgical management and support, employing a multidisciplinary team approach, and executing a well-delineated management plan provide the patient and surgeon with the best possibility of success in treating this potentially devastating condition.
C1 Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Fischer, JE (通讯作者)，Beth Israel Deaconess Med Ctr, Dept Surg, 330 Brookline Ave,Suite 9F, Boston, MA 02215 USA.
EM jfische1@bidmc.harvard.edu
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   Wang XB, 2002, WORLD J GASTROENTERO, V8, P1149, DOI 10.3748/wjg.v8.i6.1149
NR 32
TC 140
Z9 161
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD MAR
PY 2006
VL 10
IS 3
BP 455
EP 464
DI 10.1016/j.gassur.2005.08.001
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 021UA
UT WOS:000236010200025
PM 16504896
DA 2026-07-24
ER

PT J
AU Qu, XY
   Liu, GH
   Wei, WS
   Zhang, YH
   Li, KM
   Wang, XOJ
   Lang, XY
   Jiang, K
AF Qu, Xiaoyan
   Liu, Gaohua
   Wei, Wensheng
   Zhang, Yahui
   Li, Keming
   Wang, Xaiojun
   Lang, Xianyun
   Jiang, Kai
TI Staged Comprehensive Management for Necrotizing Fasciitis of the Lower
   Extremity with Sepsis: A Case Report
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID EARLY-DIAGNOSIS; SCORE
AB Necrotizing fasciitis is a severe soft tissue infection characterized by rapid necrosis of the skin, subcutaneous tissue, and fascia. Its onset is sudden, and progress is rapid. Complications such as sepsis, septic shock, and multiple organ dysfunction syndrome (MODS) can appear early, leading to high mortality and disability. The early symptoms lack specificity, posing diagnostic challenges and a high risk of misdiagnosis. This case report describes a 37-year-old male patient who presented with progressive redness, swelling, and pain of the left lower limb. Bedside incision and exploration under local anesthesia confirmed acute necrotizing fasciitis. Staged comprehensive management included early surgical debridement, empirical antibiotics, anti-shock therapy, vacuum sealing drainage, and eventual skin grafting. The patient's limb was salvaged, and at 1-year follow-up, he had returned to normal daily activities. This case may provide limited insights for the clinical management of similar patients, particularly regarding the importance of timely bedside exploration and a multidisciplinary, staged approach.
C1 [Qu, Xiaoyan; Liu, Gaohua; Wei, Wensheng; Zhang, Yahui; Li, Keming; Wang, Xaiojun; Lang, Xianyun; Jiang, Kai] 971 Hosp Peoples Liberat Army Navy, Dept Hand Surg, Qingdao, Shandong, Peoples R China.
RP Jiang, K (通讯作者)，971 Hosp Peoples Liberat Army Navy, Dept Hand Surg, Qingdao, Shandong, Peoples R China.
EM swkebq_971yy@163.com
FU Military Clinical Specialty Development and Cultivation Fund [2024]
FX Funding: Military Clinical Specialty Development and Cultivation Fund
   (2024) .
CR Bonne SL, 2017, INFECT DIS CLIN N AM, V31, P497, DOI 10.1016/j.idc.2017.05.011
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   Burn Surgery Branch of the Chinese Medical Association Editorial Board of the Chinese Journal of Burns, 2017, CHIN J BURNS, V33, P129
   Cheng NC, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1144-0
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   Hsiao CT, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0227748
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   Li Longzhu, 2015, Zhonghua Shao Shang Za Zhi, V31, P98
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   Morgan MS, 2010, J HOSP INFECT, V75, P249, DOI 10.1016/j.jhin.2010.01.028
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   Salati SA, 2024, POL J SURG, V95, DOI 10.5604/01.3001.0015.8571
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   Yilmazlar T, 2007, WORLD J SURG, V31, P1858, DOI 10.1007/s00268-007-9132-1
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JUN
PY 2026
IS 232
AR e69669
DI 10.3791/69669
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JO6BI
UT WOS:001794269200009
PM 42329972
DA 2026-07-24
ER

PT J
AU Cauthon, DJ
   Worthen, T
   Freed, L
   DeComas, AM
AF Cauthon, David J.
   Worthen, Tucker
   Freed, Lewis
   DeComas, Amalia M.
TI Malignant Eccrine Hidradenoma
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID CLEAR-CELL HIDRADENOMA; SKIN
AB Hidradenomas are adenomatous tumors of sweat gland origin that are usually benign and can occur in any cutaneous skin surface. When malignant, the tumors have high recurrence rates and are often fatal. Because of their infrequency and clinical ambiguity, hidradenomas are often misdiagnosed as other soft-tissue masses. Radiation and chemotherapy have not shown to be of benefit; therefore, wide aggressive excision and lymphadenectomy are currently the treatments of choice. We present the case of a patient with a malignant hidradenoma presenting in her medial heel. After excisional biopsy identified the tumor, the patient was successfully treated with wide excision and delayed closure via vacuum-assisted closure.
C1 [Cauthon, David J.; Worthen, Tucker] Midwestern Univ, Arizona Sch Podiatr Med, Glendale, AZ 85308 USA.
   [Freed, Lewis] East Valley Foot & Ankle Specialists, Mesa, AZ USA.
   [DeComas, Amalia M.] Core Inst, Phoenix, AZ USA.
C3 Midwestern University; Midwestern University - Glendale
RP Cauthon, DJ (通讯作者)，Midwestern Univ, Arizona Sch Podiatr Med, 19555 N 59th Ave, Glendale, AZ 85308 USA.
EM david.cauthon@gmail.com
CR Abenoza P, 1990, NEOPLASMS ECCRINE DI, P311
   CARO WA, 1985, DERMATOLOGY, P1533
   Collman David R, 2007, J Foot Ankle Surg, V46, P387, DOI 10.1053/j.jfas.2007.05.001
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   Feldman A H, 1997, J Foot Ankle Surg, V36, P21
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NR 17
TC 0
Z9 1
U1 0
U2 1
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JUL-AUG
PY 2013
VL 103
IS 4
BP 333
EP 336
DI 10.7547/1030333
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AI4PK
UT WOS:000336847100009
PM 23878386
DA 2026-07-24
ER

PT J
AU Avery, C
   Pereira, J
   Moody, A
   Gargiulo, M
   Whitworth, I
AF Avery, C
   Pereira, J
   Moody, A
   Gargiulo, M
   Whitworth, I
TI Negative pressure wound dressing of the radial forearm donor site
SO INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
DE wound dressing; negative pressure; radial donor site
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; MORBIDITY; FLAP
AB Donor site complications of the radial forearm are a significant cause of post-operative morbidity. 15 patients had radial forearm free tissue donor sites treated with split skin grafts and a negative pressure dressing. All grafts showed 100% take at 5 days. The advantages of this technique include rapid healing at an unfavourable graft recipient site, increased graft take and decreased donor site complications. This method is ideally suited for the management of large defects. The dressing can be quickly and easily applied and there have been no significant complications.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead RH19 3DZ, W Sussex, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead RH19 3DZ, W Sussex, England.
RP Avery, C (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
RI /AAI-1364-2019; moody, alan/M-9258-2019
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   BARDSLEY AF, 1990, PLAST RECONSTR SURG, V86, P287, DOI 10.1097/00006534-199008000-00014
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Johnson PA, 1998, BRIT J ORAL MAX SURG, V36, P141, DOI 10.1016/S0266-4356(98)90184-X
   Lutz BS, 1999, PLAST RECONSTR SURG, V103, P132, DOI 10.1097/00006534-199901000-00021
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Richardson D, 1997, PLAST RECONSTR SURG, V99, P109, DOI 10.1097/00006534-199701000-00017
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 9
TC 39
Z9 46
U1 0
U2 1
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0901-5027
J9 INT J ORAL MAX SURG
JI Int. J. Oral Maxillofac. Surg.
PD JUN
PY 2000
VL 29
IS 3
BP 198
EP 200
DI 10.1016/S0901-5027(00)80092-2
PG 3
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 346AH
UT WOS:000088847600008
PM 10970082
DA 2026-07-24
ER

PT J
AU Burda, R
   Kitka, M
AF Burda, R.
   Kitka, M.
TI Osteoplastic static thumb replacement for the total traumatic thumb loss
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE failed thumb replantation; thumb reconstruction; hand infection; vacuum
   assisted closure in septic hand
ID RECONSTRUCTION
AB Despite the fact that replantation of the thumb is at present a common procedure, occasionally due to the different reasons replantation is unsuccessful. We present a case where we have to cope with complete thenar loss and following reconstruction was done in an unusual way. Primarily we have covered the thenar defect with inguinal flap and secondarily we have made thumb bone replacement with heterogenous bone block fixed to the second metacarpal bone. We would like to point out that sometimes it is necessary to make reconstructions by unusual way
C1 [Burda, R.; Kitka, M.] Fac Hosp Louis Pasteur, Dept Trauma Surg, SK-04080 Kosice, Slovakia.
RP Burda, R (通讯作者)，Fac Hosp Louis Pasteur, Dept Trauma Surg, Rastislavova 43, SK-04080 Kosice, Slovakia.
EM burda@netkosice.sk
RI Burda, Rastislav/AAJ-4414-2020
OI Burda, Rastislav/0000-0003-2856-2796; Kitka,
   Miroslav/0000-0003-2614-1496
CR ASCHE C, 1980, HANDCHIRURGIE, V12, P257
   Brenner P, 1997, SCAND J PLAST RECONS, V31, P165, DOI 10.3109/02844319709085484
   Ferbert T, 2004, ZENTRALBL CHIR, V129, P57
   FOUCHER G, 1984, J HAND SURG-BRIT EUR, V9B, P245, DOI 10.1016/0266-7681(84)90033-0
   Huang WS, 2006, ASIAN J SURG, V29, P133
   LEE WP, 2005, GREENS OPERATIVE HAN
   MALEY P, 1999, MICROSURG, V19, P153
   Merle M, 1996, B ACAD NAT MED PARIS, V180, P195
   Pelissier P, 1998, Ann Chir Plast Esthet, V43, P182
   Schwabegger AH, 1999, UNFALLCHIRURG, V102, P292, DOI 10.1007/s001130050405
   SEYHAN H, 2006, ZBI CHIR S1, V131, P33
   Sharma S, 2005, ANN PLAS SURG, V55, P352, DOI 10.1097/01.sap.0000181343.23091.93
   Sukop A, 2005, Acta Chir Plast, V47, P103
   Unglaub F, 2006, MICROSURG, V26, P552, DOI 10.1002/micr.20287
NR 14
TC 1
Z9 1
U1 0
U2 0
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2009
VL 110
IS 1
BP 38
EP 42
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 418OY
UT WOS:000264159100008
PM 19408829
DA 2026-07-24
ER

PT J
AU Espensen, EH
   Nixon, BP
   Lavery, LA
   Armstrong, DG
AF Espensen, EH
   Nixon, BP
   Lavery, LA
   Armstrong, DG
TI Use of subatmospheric (VAC) therapy to improve bioengineered tissue
   grafting in diabetic foot wounds
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID ULCERS
AB The use of bioengineered tissue and topical subatmospheric pressure therapy have both been widely accepted as adjunctive therapies for the treatment of noninfected, nonischemic diabetic foot wounds. This article describes a temporally overlapping method of care that includes a period of simultaneous application of bioengineered tissue (Apligraf, Novartis Pharmaceuticals Corp, East Hanover, New Jersey) and subatmospheric pressure therapy delivered through the VAC (Vacuum Assisted Closure) system (KCI, Inc, San Antonio, Texas). Future descriptive and analytic works may test the hypothesis that combined therapies used at different and often overlapping periods during the wound-healing cycle may be more effective than a single modality.
C1 Providence St Joseph Med Ctr, Diabet Foot Ctr, Burbank, CA USA.
RP Espensen, EH (通讯作者)，So Arizona Vet Affairs Med Ctr, Dept Surg, Podiatry Sect, 3601 S 6th Ave, Tucson, AZ 85723 USA.
CR Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Genecov DG, 1998, ANN PLAS SURG, V40, P219, DOI 10.1097/00000637-199803000-00004
   Gentzkow GD, 1996, DIABETES CARE, V19, P350, DOI 10.2337/diacare.19.4.350
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
NR 5
TC 27
Z9 38
U1 0
U2 4
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JUL-AUG
PY 2002
VL 92
IS 7
BP 395
EP 397
DI 10.7547/87507315-92-7-395
PG 3
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 576AC
UT WOS:000176979800007
PM 12122126
DA 2026-07-24
ER

PT J
AU Töpel, I
   Steinbauer, M
AF Toepel, I.
   Steinbauer, M.
TI Biological protection procedures for infectious complications in the
   groin
SO GEFASSCHIRURGIE
LA German
DT Article
DE Infection; Groin; Biological protection procedure; Complications
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; GROWTH-FACTOR; WOUNDS;
   TRANSPOSITION; MANAGEMENT; THERAPY; OMENTUM
AB Infectious complications after vascular surgery appear infrequently but they are associated with a high morbidity and mortality. Due to high microbial colonization the groin is one of the high risk areas of the body concerning wound infections after surgical procedures. The treatment of infectious vascular complications requires complex surgical strategies accompanied by sufficient antibiotic treatment and risk factor management. Surgical therapy of graft infections without biological protection procedures is inefficient. Therefore, knowledge and skills in reconstructive soft tissue procedures in the groin are growing in importance.
C1 [Toepel, I.; Steinbauer, M.] Krankenhaus Barmherzige Bruder Regensburg, Klin Gefasschirurg, D-93049 Regensburg, Germany.
RP Töpel, I (通讯作者)，Krankenhaus Barmherzige Bruder Regensburg, Klin Gefasschirurg, Prufeninger Str 86, D-93049 Regensburg, Germany.
EM ingolf.toepel@barmherzige-regensburg.de
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   Buckland A, 2009, PLAST RECONSTR SURG, V123, P44, DOI 10.1097/PRS.0b013e3181904bc6
   Dosluoglu HH, 2010, J VASC SURG, V51, P1160, DOI 10.1016/j.jvs.2009.11.053
   Harding K, 2008, INT WOUND J, V5, P597, DOI 10.1111/j.1742-481X.2008.00569.x
   Hultman CS, 2002, ANN SURG, V235, P782, DOI 10.1097/00000658-200206000-00005
   Liebermann-Meffert D, 2000, SURG CLIN N AM, V80, P275, DOI 10.1016/S0039-6109(05)70406-0
   Liebermann-Meffert D, 2000, SURG CLIN N AM, V80, pxii, DOI DOI 10.1016/S0039-6109(05)70406-0
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
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   Zuhlke H, 1994, SEPTISCHE GEFASSCHIR
NR 15
TC 2
Z9 2
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0948-7034
EI 1434-3932
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD FEB
PY 2012
VL 17
IS 1
BP 63
EP 71
DI 10.1007/s00772-011-0992-1
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 893AS
UT WOS:000300328000010
DA 2026-07-24
ER

PT J
AU Gaston, RG
   Kuremsky, MA
AF Gaston, R. Glenn
   Kuremsky, Marshall A.
TI Postoperative Infections: Prevention and Management
SO CRITICAL CARE NURSING CLINICS OF NORTH AMERICA
LA English
DT Article
DE Postoperative; Infection; Hand; Osteomyelitis; Wrist
ID RESISTANT STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED CLOSURE;
   RHEUMATOID-ARTHRITIS PATIENTS; SURGICAL WOUND-INFECTION; FLEXIBLE
   IMPLANT ARTHROPLASTY; UPPER EXTREMITY INFECTIONS; PRESSURE PULSATILE
   LAVAGE; PREOPERATIVE HAIR REMOVAL; ELECTIVE HAND SURGERY; LYMPH-NODE
   DISSECTION
AB Postoperative Infections: Prevention and Management R. Glenn Gaston and Marshall A. Kuremsky Postoperative infections continue to be a challenging problem. The incidence of bacterial antibiotic resistance such as methicillin-resistant Staphylococcus aureus is rising. There are numerous intrinsic patient factors that should be optimized before surgery to minimize the risk of surgical site infections. When postoperative infections develop, treatment must be individualized. This article outlines the principles that can help guide treatment.
C1 [Kuremsky, Marshall A.] Carolinas Med Ctr, Dept Orthoped, Charlotte, NC 28203 USA.
   [Gaston, R. Glenn] OrthoCarolina, Charlotte, NC 28207 USA.
C3 Carolinas Medical Center
RP Gaston, RG (通讯作者)，OrthoCarolina, 1915 Randolph Rd, Charlotte, NC 28207 USA.
EM glenngaston@hotmail.com
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NR 139
TC 6
Z9 7
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0899-5885
EI 1558-3481
J9 CRIT CARE NURS CLIN
JI Crit. Care Nurs. Clin. N. Am.
PD JUN
PY 2012
VL 24
IS 2
BP 323
EP +
DI 10.1016/j.ccell.2012.03.007
PG 23
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 068VV
UT WOS:000313395200011
PM 22548866
DA 2026-07-24
ER

PT J
AU Zhang, Y
   Tong, Y
   Chen, XJ
   Luo, JC
   Bi, Q
AF Zhang, Yin
   Tong, Yu
   Chen, Xinji
   Luo, Junchao
   Bi, Qing
TI Rapidly expanding giant neurofibroma of the back with intratumoral
   hematoma: a case report and literature review
SO BRITISH JOURNAL OF NEUROSURGERY
LA English
DT Review
DE rapidly expanding giant neurofibroma; intratumoral hematoma; case
   report; review
AB Neurofibromatosis type I is a common genetic disease that can lead to disfigurement, neurological and functional disorders. However, it is rare to meet the case which a huge mass is formed rapidly after neurofibroma ruptures. This case report describes a rare case of a 52-year-old female with a rapidly expanding mass on her back and mild anemia as the main symptoms. Physical examination showed a huge mass on the back and a surface ulceration with the diameter of 6 cm. Imaging examination revealed the abundant blood supply to the lesion. We performed preoperative arterial embolization, and surgical resection on the fifth day after embolization. After operation, proper blood transfusion and vacuum sealing drainage (VSD) were given. Through 9-months follow-up study, the incision of the patient recovered well and there was no sign of tumor recurrence. Therefore, this case report provides clinicians with valuable experience in the treatment for rapidly expanding neurofibroma.
C1 [Zhang, Yin; Bi, Qing] Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.
   [Tong, Yu; Luo, Junchao] Wenzhou Med Univ, Affiliated Hosp 2, Wenzhou, Peoples R China.
   [Tong, Yu; Luo, Junchao] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
   [Chen, Xinji; Bi, Qing] Zhejiang Prov Peoples Hosp, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China.
   [Chen, Xinji; Bi, Qing] Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China.
C3 Bengbu Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Hangzhou Medical College; Zhejiang Provincial People's
   Hospital; Hangzhou Medical College
RP Bi, Q (通讯作者)，Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China.; Bi, Q (通讯作者)，Zhejiang Prov Peoples Hosp, Dept Orthoped Surg, Hangzhou, Zhejiang, Peoples R China.
EM bqzjsrmyy@163.com
OI TONG, YU/0000-0001-9895-6948
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NR 9
TC 1
Z9 2
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0268-8697
EI 1360-046X
J9 BRIT J NEUROSURG
JI Br. J. Neurosurg.
PD NOV 2
PY 2023
VL 37
IS 6
BP 1709
EP 1713
DI 10.1080/02688697.2020.1834508
EA OCT 2020
PG 5
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA HC0R6
UT WOS:000579890300001
PM 33078971
DA 2026-07-24
ER

PT J
AU Loske, G
   Müller, CT
AF Loske, G.
   Mueller, C. T.
TI Tips and tricks for endoscopic negative pressure therapy. German version
SO CHIRURG
LA German
DT Article
DE Endoscopic vacuum therapy; Leakage; Drainage; Overtube; Esophagus
ID OPEN-PORE FILM; VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE;
   POLYURETHANE FOAM; DRAINAGE; DEVICE; PERFORATION; ABSCESS; EVT
AB Endoscopic negative-pressure therapy (ENPT) is becoming avaluable tool in surgical complication management of transmural intestinal defects and wounds in the upper and lower gastrointestinal tract. Innovative materials for drains have been developed, endoscopic techniques adapted, and new indications for ENPT have been found. Based on our broad clinical experience, numerous tips and tricks are described, which contribute to the safety of dealing with the new therapy. The aim of this work is to present these methods. The focus is on describing the treatment in the esophagus.
C1 [Loske, G.; Mueller, C. T.] Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Loske, G (通讯作者)，Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM Loske.chir@marienkrankenhaus.org
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NR 25
TC 8
Z9 9
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD NOV
PY 2018
VL 89
IS 11
BP 887
EP 895
DI 10.1007/s00104-018-0715-1
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HC4JO
UT WOS:000451769800007
PM 30288601
OA hybrid
DA 2026-07-24
ER

PT J
AU Pozez, AL
   Aboutanos, SZ
   Lucas, VS
AF Pozez, Andrea L.
   Aboutanos, Sharline Z.
   Lucas, Valentina S.
TI Diagnosis and treatment of uncommon wounds
SO CLINICS IN PLASTIC SURGERY
LA English
DT Article
ID SQUAMOUS-CELL CARCINOMA; VACUUM-ASSISTED CLOSURE; LEG ULCERS;
   VIBRIO-VULNIFICUS; BED PREPARATION; CALCIPHYLAXIS; KLIPPEL; BASAL;
   INFECTIONS; PATIENT
AB Uncommon wounds present unique challenges to plastic surgeons and other wound care providers in regard to their presentation, recognition, and ultimate treatment. This article presents an overview of diagnosis and actual case treatment of unusual wounds, a review of the literature, and case studies of interest. A systematic approach to diagnosis; careful review of history; and full understanding of topical, systemic, and surgical therapies is paramount to proper treatment recommendations, appropriate patient management, and successful wound-healing outcomes. The ability to identify and treat wounds caused by an unusual etiology or presentation is an important skill.
C1 Virginia Commonwealth Univ, VCU Med Ctr, Div Plast & Reconstruct Surg, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, VCUHS Wound Care Team, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Pozez, AL (通讯作者)，Virginia Commonwealth Univ, VCU Med Ctr, Div Plast & Reconstruct Surg, 1200 E Broad St,Box 980154, Richmond, VA 23298 USA.
EM alpozez@vcu.edu
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NR 73
TC 3
Z9 4
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD OCT
PY 2007
VL 34
IS 4
BP 749
EP +
DI 10.1016/j.cps.2007.08.012
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 238US
UT WOS:000251473800013
PM 17967628
DA 2026-07-24
ER

PT J
AU Loske, G
   Müller, CT
AF Loske, G.
   Mueller, C. T.
TI Tips and tricks for endoscopic negative pressure therapy
SO CHIRURG
LA English
DT Review
DE Endoscopic vacuum therapy; Leakage; Drainage; Overtube; Esophagus
ID OPEN-PORE FILM; VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE;
   POLYURETHANE FOAM; DRAINAGE; DEVICE; PERFORATION; ABSCESS; EVT
AB Endoscopic negative-pressure therapy (ENPT) is becoming avaluable tool in surgical complication management of transmural intestinal defects and wounds in the upper and lower gastrointestinal tract. Innovative materials for drains have been developed, endoscopic techniques adapted, and new indications for ENPT have been found. Based on our broad clinical experience, numerous tips and tricks are described, which contribute to the safety of dealing with the new therapy. The aim of this work is to present these methods. The focus is on describing the treatment in the esophagus.
C1 [Loske, G.; Mueller, C. T.] Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
C3 St. Marien Hospital
RP Loske, G (通讯作者)，Katholisches Marienkrankenhaus Hamburg gGmbH, Klin Allgemein Viszeral Thorax & Gefasschirurg, Alfredstr 9, D-22087 Hamburg, Germany.
EM Loske.chir@marienkrankenhaus.org
CR Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
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   Laukoetter MG, 2017, SURG ENDOSC, V31, P2687, DOI 10.1007/s00464-016-5265-3
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NR 25
TC 51
Z9 61
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD JAN
PY 2019
VL 90
SU 1
BP S7
EP S14
DI 10.1007/s00104-018-0725-z
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI8OX
UT WOS:000456716700002
PM 30280205
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Cooper, CE
   Kennedy, AP
   Smith, DP
AF Cooper, Caleb E.
   Kennedy, Alfred P., Jr.
   Smith, D. Preston
TI Abdominal Compartment Syndrome in a Pediatric Patient With Cloacal
   Exstrophy
SO UROLOGY
LA English
DT Article
ID CHILDREN
AB We present a rare complication of abdominal compartment syndrome (ACS) in a child undergoing complex urologic reconstruction. A 10-year-old female born with the abdominal wall defect cloacal exstrophy who had previously undergone multiple abdominal procedures then developed findings consistent with ACS following a complex Mitrofanoff procedure. Although intravesical pressures were not documented because of the nature of her reconstruction, her ACS type findings were (1) abdominal pain, (2) melena, (3) pulmonary hypoinflation, (4) renal insufficiency, (5) tachycardia, and (6) segmental ischemic small bowel. Management consisted of abdominal decompression, segmental bowel resections, and wound vacuum-assisted-closure management. Patient was eventually discharged home. (C) 2016 Elsevier Inc.
C1 [Smith, D. Preston] East Tennessee Childrens Hosp, Pediat Urol, 2100 Clinch Ave,MOB Suite 120, Knoxville, TN 37916 USA.
   Geisinger Hlth Syst, Pediat Surg, Danville, PA USA.
C3 Geisinger Health System
RP Smith, DP (通讯作者)，East Tennessee Childrens Hosp, Pediat Urol, 2100 Clinch Ave,MOB Suite 120, Knoxville, TN 37916 USA.
EM dpsmith@univpedurology.com
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NR 10
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD JUL
PY 2016
VL 93
BP 185
EP 187
DI 10.1016/j.urology.2016.02.025
PG 3
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DP3EB
UT WOS:000378374100056
PM 26921644
DA 2026-07-24
ER

PT J
AU Weston, C
AF Weston, C.
TI The Science behind Topical Negative Pressure Therapy
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Topical negative pressure therapy; VAC (R) Therapy; matrix
   metalloproteinase; cytokines; microvascular blood flow; perfusion; cell
   strain
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; SUBATMOSPHERIC PRESSURE;
   CELL-SHAPE; METALLOPROTEINASES; PROGRESSION; SKIN
AB Topical negative pressure therapy (TNP) is an established part of modern wound healing. With an increasing choice in TNP providers, understanding the differing modes of action, the biochemical and biophysical effects on the Wound at a microscopic and macroscopic level, Plus the role of the interface dressings. will aid the clinician in planning C! it clear goal of therapy. This article reviews the scientific evidence for TNP to date and explores each mechanism of action and the implications for wound healing and patient Outcomes.
C1 KCI Med Ltd, No Europe, Oxford OX5 1GF, England.
RP Weston, C (通讯作者)，KCI Med Ltd, No Europe, KCI House, Oxford OX5 1GF, England.
EM cweston@kci-medical.com
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NR 35
TC 3
Z9 4
U1 0
U2 2
PU ACTA MEDICAL BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138 A, B-1180 BRUSSELS, BELGIUM
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD FEB
PY 2010
VL 110
IS 1
BP 19
EP 27
DI 10.1080/00015458.2010.11680559
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 570EF
UT WOS:000275654000007
PM 20306904
DA 2026-07-24
ER

PT J
AU Crosse, PA
   Soares, K
   Wheeler, JL
   Cooke, KL
   Adin, CA
   O'Kelley, JJ
   Levy, JK
AF Crosse, PA
   Soares, K
   Wheeler, JL
   Cooke, KL
   Adin, CA
   O'Kelley, JJ
   Levy, JK
TI Chromobacterium violaceum infection in two dogs
SO JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ACUTE PLEUROPNEUMONIA; WOUND CONTROL;
   SEPTICEMIA
AB Chromobacterium violaceum is a saprophyte of soil and water in tropical and subtropical environments that is associated with rare but highly fatal infections in animals and humans. Systemic infection was diagnosed in two critically ill dogs from Florida. Fever was absent in both dogs. Both dogs were treated surgically and provided with intensive care, but only one survived. The identification of characteristic, violet-pigmented bacterial colonies on routine microbial cultures should alert microbiologists and clinicians to the likelihood of this dangerous pathogen. Because of the rapidly progressive nature of this infection, empirical antibiotic administration with fluoro-quinolones should be employed pending susceptibility testing.
C1 Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
   Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Levy, JK (通讯作者)，Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
RI Levy, Julie/JED-7223-2023; /J-9753-2012
OI Levy, Julie/0000-0002-4849-288X; 
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NR 30
TC 11
Z9 13
U1 0
U2 2
PU AMER ANIMAL HOSPITAL ASSOC
PI LAKEWOOD
PA PO BOX 150899, LAKEWOOD, CO 80215-0899 USA
SN 0587-2871
J9 J AM ANIM HOSP ASSOC
JI J. Am. Anim. Hosp. Assoc.
PD MAR-APR
PY 2006
VL 42
IS 2
BP 154
EP 159
DI 10.5326/0420154
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 054LS
UT WOS:000238378800010
PM 16527917
DA 2026-07-24
ER

PT J
AU Mirza, W
   Khan, ME
   Iqbal, H
   Khan, A
   Khan, HM
   Moeen-Ud-Din, MB
   Hadhoud, AM
AF Mirza, Wajahat
   Khan, Mehak Ejaz
   Iqbal, Hania
   Khan, Alishbah
   Khan, Hadi Mohammad
   Moeen-Ud-Din, Muhammad Bilal
   Hadhoud, Abdalla M.
TI Negative-pressure wound therapy versus conventional dressings following
   stoma reversal: a GRADE-based systematic review and meta-analysis of
   randomized controlled trials with predefined subgroup analyses by
   closure technique
SO BMC SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Stoma reversal; Surgical site
   infection; Ileostomy closure; Colostomy closure; Wound healing;
   Meta-analysis; Randomized controlled trial; Purse-string closure; Linear
   primary closure
ID PREVENTION
AB BackgroundSurgical site infection (SSI) after stoma reversal remains common (15-40%), prolonging hospitalization and potentially delaying adjuvant therapy. Prophylactic negative-pressure wound therapy (NPWT) is increasingly used for closed incisions; however, its efficacy with different skin-closure techniques remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials comparing NPWT with conventional non-pressure dressings after stoma reversal, with prespecified subgroup analyses by skin-closure technique and certainty of evidence appraised using GRADE.MethodsThe review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (CRD420251182767). We searched MEDLINE, Embase, Scopus, Web of Science, CENTRAL, ClinicalTrials.gov, and WHO ICTRP without language restrictions. Eligible randomized controlled trials enrolled adults undergoing elective ileostomy or colostomy reversal and compared negative-pressure wound therapy (NPWT) with conventional (non-pressure) dressings with a specified skin-closure technique (purse-string or primary). The primary outcome was incisional surgical site infection within 30-42 days of surgery. Secondary outcomes included length of stay, time to complete wound healing, operative duration, and estimated blood loss. Two reviewers independently screened the studies, extracted data, and assessed the risk of bias using RoB 2. Random-effects meta-analyses were conducted with sensitivity analyses and pre-specified subgroup comparisons based on closure techniques. The certainty of evidence was appraised using GRADE.ResultsSeven randomized trials (n = 429) met the inclusion criteria (NPWT, n = 220; conventional dressings, n = 209). The primary pooled analysis showed no significant reduction in incisional SSI with NPWT versus conventional dressings (RR 0.42, 95% CI 0.14-1.30; I & sup2;=46%). By closure technique, the effects were larger with primary closure (RR 0.20, 95% CI 0.06-0.67; I & sup2;=0%) than with purse-string closure (RR 0.68, 95% CI 0.14-3.35; I & sup2;=48%), although the interaction was not statistically significant (P = 0.23). The risk of bias was generally rated as "some concerns," primarily due to open-label care, and heterogeneity was low after the sensitivity analysis.Prespecified leave-one-out analyses identified influential studies for SSI, length of stay, and wound healing; however, these findings were interpreted as exploratory influence diagnostics and did not replace the primary pooled analyses.ResultsSeven randomized trials (n = 429) met the inclusion criteria (NPWT, n = 220; conventional dressings, n = 209). The primary pooled analysis showed no significant reduction in incisional SSI with NPWT versus conventional dressings (RR 0.42, 95% CI 0.14-1.30; I & sup2;=46%). By closure technique, the effects were larger with primary closure (RR 0.20, 95% CI 0.06-0.67; I & sup2;=0%) than with purse-string closure (RR 0.68, 95% CI 0.14-3.35; I & sup2;=48%), although the interaction was not statistically significant (P = 0.23). The risk of bias was generally rated as "some concerns," primarily due to open-label care, and heterogeneity was low after the sensitivity analysis.Prespecified leave-one-out analyses identified influential studies for SSI, length of stay, and wound healing; however, these findings were interpreted as exploratory influence diagnostics and did not replace the primary pooled analyses.
   ConclusionsIn this primary pooled analysis, prophylactic NPWT did not significantly reduce incisional surgical site infection after stoma reversal, although the effect favored NPWT. Exploratory sensitivity and subgroup analyses suggested possible benefits in selected contexts, although these findings should not supersede the nonsignificant primary pooled analyses. Larger, standardized randomized trials are needed to clarify which closure techniques and patient groups derive the greatest benefit.
C1 [Mirza, Wajahat] Shifa Tameer e Millat Univ, Shifa Coll Med, Sect H 8-4, Islamabad, Pakistan.
   [Khan, Mehak Ejaz; Iqbal, Hania; Khan, Alishbah] Shifa Int Hosp, Resident Gen Surg, Islamabad, Pakistan.
   [Khan, Hadi Mohammad] Shifa Int Hosp, Dept Gen Surg & Surg Oncol, Islamabad, Pakistan.
   [Moeen-Ud-Din, Muhammad Bilal; Hadhoud, Abdalla M.] Univ Cincinnati, Dept Surg, Cincinnati, OH USA.
C3 Shifa College of Medicine; University System of Ohio; University of
   Cincinnati
RP Mirza, W (通讯作者)，Shifa Tameer e Millat Univ, Shifa Coll Med, Sect H 8-4, Islamabad, Pakistan.
EM wajahatmirza.clinicalresearch@gmail.com; mehak.ejazz@gmail.com;
   haniaiqbal000@gmail.com; alishkhan43@gmail.com; hadi.khan786@gmail.com;
   moeenumd@ucmail.uc.edu; hadhouam@ucmail.uc.edu
FX No external funding was received for this systematic review and
   meta-analysis.
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JUN 19
PY 2026
VL 26
IS 1
AR 421
DI 10.1186/s12893-026-03957-2
EA JUN 2026
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JT2IN
UT WOS:001797407200001
PM 42316134
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Marchand, LS
   Slobogean, G
   O'Hara, NN
   Harris, AD
   Grainger, DW
   Thabane, L
   Bhandari, M
   Della Rocca, GJ
   Kellam, PJ
   Zura, RD
   Marvel, D
   Wells, JL
   Gitajn, IL
   Jeray, KJ
   O'Toole, RV
   Working, ZM
   Natoli, RM
   Bergin, PF
   Hagen, JE
   Levack, AE
   Guerra-Farfan, E
   Schrank, GM
   Hebden, JN
   Mossuto, F
   Tsoutsounakis, C
   Pogorzelski, D
   Pineda, H
   Bzovsky, S
   Sprague, S
AF Marchand, Lucas S.
   Slobogean, Gerard
   O'Hara, Nathan N.
   Harris, Anthony D.
   Grainger, David W.
   Thabane, Lehana
   Bhandari, Mohit
   Della Rocca, Gregory J.
   Kellam, Patrick J.
   Zura, Robert D.
   Marvel, Debra
   Wells, Jeffrey L.
   Gitajn, I. Leah
   Jeray, Kyle J.
   O'Toole, Robert, V
   Working, Zachary M.
   Natoli, Roman M.
   Bergin, Patrick F.
   Hagen, Jennifer E.
   Levack, Ashley E.
   Guerra-Farfan, Ernesto
   Schrank, Gregory M.
   Hebden, Joan N.
   Mossuto, Franca
   Tsoutsounakis, Cassandra
   Pogorzelski, David
   Pineda, Hailey
   Bzovsky, Sofia
   Sprague, Sheila
CA BvV Investigators
TI Randomised controlled trial comparing antibiotic cement bead pouch
   versus negative pressure wound therapy for the management of severe open
   tibia fracture wounds: Beads versus VAC (BvV) protocol
SO BMJ OPEN
LA English
DT Article
DE ORTHOPAEDIC & TRAUMA SURGERY; Adult orthopaedics; Trauma management
ID LOADED ACRYLIC CEMENT; SURGICAL SITE INFECTIONS; ACUTE KIDNEY INJURY;
   IN-VITRO ELUTION; QUALITY-OF-LIFE; BONE-CEMENT; PROSTHESIS; RELEASE;
   POWDER; ARTHROPLASTY
AB Introduction Early open fracture management aims to minimise the risk of complications. For the most severe open fracture wounds, multiple irrigation and debridement surgeries are required to overcome severe wound contamination, to reassess the evolving tissue injury or to temporise and plan further surgery. When multiple irrigation and debridement surgeries are needed, uncertainty remains about how the open fracture wound should be managed to best minimise complications. The primary aim of this trial is to compare the antibiotic cement bead pouch vs negative pressure wound therapy in the management of patients with severe open tibia fracture wounds.<br /> Methods and analysis BvV is a multicentre, pragmatic, parallel arm randomised controlled trial that aims to enrol 312 adult patients admitted to a participating centre with a severe open tibia fracture requiring multiple irrigation and debridement surgeries. Participants will be randomly allocated on a 1:1 basis to either antibiotic cement bead pouch or negative pressure wound therapy. The primary outcome will be a composite outcome to evaluate clinical status 6 months after randomisation. Using the win ratio approach, we will hierarchically assess the composite outcome in the following order: (i) all-cause mortality, (ii) injury-related amputation of the lower extremity, (iii) unplanned reoperation to manage wound complications, an infection or promote fracture healing and (iv) clinical fracture healing assessed using the Functional IndeX for Trauma (FIX-IT) instrument.<br /> Ethics and dissemination The BvV trial has been approved by a central institutional review board (IRB) (Advarra) for clinical sites in the USA, the ethics board at the coordinating centre at McMaster University (Hamilton Integrated Research Ethics Board), and participating sites not using the central institutional IRB (Fraser Health Research Ethics Board, The University of British Columbia Clinical Research Ethics Board, Newfoundland and Labrador Health Research Ethics Board, University of Manitoba Biomedical Research Ethics Board). Additional clinical sites who are in the start-up phase, as well as any new selected clinical sites, will obtain local approvals prior to initiating trial activities. This will include a clinical site in the UK who is in the process of obtaining the necessary approvals. Recruitment began in November 2023. Both interventions are frequently used to manage severe open fracture wounds, ensuring that the trial results can be easily transitioned into clinical practice. The results of this trial will be disseminated to national and international partners through peer-reviewed publications, academic conferences and stakeholder engagement activities.
C1 [Marchand, Lucas S.] Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84112 USA.
   [Slobogean, Gerard] Univ Calif Irvine, Dept Orthoped Surg, Orange, CA USA.
   [O'Hara, Nathan N.; O'Toole, Robert, V] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Ctr Orthopaed Injury Res & Innovat, Dept Orthopaed,Sch Med, Baltimore, MD USA.
   [Harris, Anthony D.; Hebden, Joan N.] Univ Maryland, Dept Epidemiol & Publ Hlth, Sch Med, Baltimore, MD USA.
   [Grainger, David W.] Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA.
   [Thabane, Lehana] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
   [Bhandari, Mohit; Pogorzelski, David; Pineda, Hailey; Bzovsky, Sofia; Sprague, Sheila] McMaster Univ, Dept Surg, Div Orthopaed Surg, Hamilton, ON, Canada.
   [Della Rocca, Gregory J.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO USA.
   [Kellam, Patrick J.] UTHealth Houston, McGovern Med Sch, Dept Orthoped Surg, Houston, TX USA.
   [Zura, Robert D.] LSUHSC Orthopaed New Orleans, New Orleans, LA USA.
   [Marvel, Debra; Wells, Jeffrey L.] Univ Maryland Baltimore, Patient Representat, Baltimore, MD USA.
   [Gitajn, I. Leah] Dartmouth Hitchcock Med Ctr, Dept Orthopaed Surg, Lebanon, NH USA.
   [Jeray, Kyle J.] Univ South Carolina, Dept Orthoped Surg, Prisma Hlth Upstate, Greenville, SC USA.
   [Working, Zachary M.] Oregon Hlth & Sci Univ, Dept Orthopaed & Rehabil, Portland, OR USA.
   [Natoli, Roman M.] IU Methodist Hosp, Dept Orthopaed Surg, Div Orthopaed Trauma, Indianapolis, IN USA.
   [Bergin, Patrick F.] Univ Mississippi, Dept Orthopaed Surg & Rehabil, Med Ctr, Jackson, MS USA.
   [Hagen, Jennifer E.] Univ Florida, Dept Orthopaed Surg & Sports Med, Div Orthopaed Trauma, Gainesville, FL USA.
   [Levack, Ashley E.] Loyola Univ Med Ctr, Dept Orthopaed Surg & Rehabil, Maywood, IL USA.
   [Levack, Ashley E.] Stritch Sch Med, Maywood, IL USA.
   [Guerra-Farfan, Ernesto] Hosp Univ Vall dHebron, Dept Orthoped Surg & Traumatol, Barcelona, Spain.
   [Schrank, Gregory M.] Univ Maryland, Dept Med, Div Infect Dis, Sch Med, Baltimore, MD USA.
   [Mossuto, Franca] Hamilton Hlth Sci Hosp, Div Orthopaed Surg, Gen Site, Hamilton, ON, Canada.
   [Tsoutsounakis, Cassandra] Univ Utah Hosp, Salt Lake City, UT USA.
   [Sprague, Sheila] Johns Hopkins Univ, Dept Plast & Reconstruct Surg, Baltimore, MD USA.
C3 Utah System of Higher Education; University of Utah; University of
   California System; University of California Irvine; University System of
   Maryland; University of Maryland Baltimore; University System of
   Maryland; University of Maryland Baltimore; Utah System of Higher
   Education; University of Utah; McMaster University; McMaster University;
   University of Missouri System; University of Missouri Columbia;
   University System of Maryland; University of Maryland Baltimore;
   Dartmouth College; Prisma Health; Oregon Health & Science University;
   University of Mississippi; University of Mississippi Medical Center;
   State University System of Florida; University of Florida; Loyola
   University Chicago; Loyola University Chicago; Hospital Universitari
   Vall d'Hebron; University System of Maryland; University of Maryland
   Baltimore; Utah System of Higher Education; University of Utah;
   University of Utah Hospital; Johns Hopkins University
RP Marchand, LS (通讯作者)，Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84112 USA.
EM lucas.marchand@hsc.utah.edu; gslobogean@som.umaryland.edu;
   NO'Hara@som.umaryland.edu; aharris@som.umaryland.edu;
   david.grainger@utah.edu; thabanl@mcmaster.ca; bhandam@mcmaster.ca;
   dellaroccag@health.missouri.edu; patrick.j.kellam@uth.tmc.edu;
   rzura@lsuhsc.edu; debramarvel@comcast.net; wellsjl@gmail.com;
   Ida.Leah.Gitajn@Hitchcock.ORG; kyle.jeray@prismahealth.org;
   ROtoole@som.umaryland.edu; workingz@ohsu.edu; rnatoli@iuhealth.org;
   pbergin@umc.edu; hagenje@ortho.ufl.edu; ashley.levack@lumc.edu;
   ernestoguerraf@gmail.com; gschrank@som.umaryland.edu;
   jhebden@som.umaryland.edu; francamossuto25@gmail.com;
   Cassi.Tsoutsounakis@hsc.utah.edu; pogorzd@mcmaster.ca;
   pinedh1@mcmaster.ca; bzovskys@mcmaster.ca; sprags@mcmaster.ca
RI OToole, Robert/HKN-8717-2023; Guerra-Farfan, Ernesto/D-4732-2012;
   Natoli, Roman/AAE-6397-2022; Working, Zachary/AAT-6760-2021; Della
   Rocca, Gregory/AAM-5281-2021; Wells, Jeffrey/AAQ-4232-2021
OI Kommu, Karan/0009-0001-9196-3202; Pineda, Hailey/0009-0001-7648-9135;
   Schrank, Gregory/0000-0002-3013-139X; Wells, Jeffrey/0000-0001-5032-0836
FU US Department of Defense Peer-Reviewed Orthopaedic Research Program
   [W81XWH]
FX This trial is funded by the US Department of Defense Peer-Reviewed
   Orthopaedic Research Program (W81XWH-22-1-0863). The funder of the trial
   had no role in the trial design or writing of the protocol.
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NR 50
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY 28
PY 2026
VL 16
IS 5
AR e088521
DI 10.1136/bmjopen-2024-088521
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HK5XA
UT WOS:001756268500001
PM 42082225
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chang, H
   Maldonado, TS
   Rockman, CB
   Cayne, NS
   Berland, TL
   Barfield, ME
   Jacobowitz, GR
   Sadek, M
AF Chang, Heepeel
   Maldonado, Thomas S.
   Rockman, Caron B.
   Cayne, Neal S.
   Berland, Todd L.
   Barfield, Michael E.
   Jacobowitz, Glenn R.
   Sadek, Mikel
TI Closed incision negative pressure wound therapy may decrease wound
   complications in major lower extremity amputations
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Amputation; Peripheral artery disease; Negative pressure wound therapy;
   Below-knee amputation; Above-knee amputation
ID TRIAL
AB Objective: Wound complications after major lower extremity amputations (LEAs) are a cause of significant morbidity in vascular surgery patients. Recent publications have demonstrated the efficacy of the closed incision negative pressure dressing at preventing surgical site infections (SSIs); however, there are few data on its use in major LEAs. This study sought to assess if closed incision negative pressure wound therapy (NPWT) would decrease the risk of complications as compared with a standard dressing in patients with peripheral vascular disease undergoing major LEA.
   Methods: Fifty-four consecutive patient limbs with a history of peripheral arterial disease underwent below-knee or above-knee amputations. This was a retrospective review of a prospectively maintained database from January 2018 to December 2019, and it included 23 amputations in the NPWT group and 31 amputations in the standard dressing group. NPWT using the PREVENA system was applied intraoperatively at the discretion of the operating surgeon and removed 5 to 7 days postoperatively. The standard group received a nonadherent dressing with an overlying compression dressing. Amputation incisions were assessed and wound complications were recorded. Student's t-test and two-sample proportion z-test were used for statistical analysis. A P value of less than .05 was considered statistically significant.
   Results: For comorbidities, there was a higher incidence of tobacco use in the NPWT as compared with the standard group (44% vs 13%; P= .011), as well as trends toward increased prior amputations, anemia, hyperlipidemia, and chronic obstructive pulmonary disorder in the NPWT group. For risk factors, there were more dirty wounds in the NPWT as compared with the standard group (52% vs 26%; P= .046). For outcomes, there were fewer wound complications in the NPWT as compared with the standard group (13% vs 39%; P = .037). The types of wound-related complications in the NPWT group included one wound dehiscence with a deep SSI, one superficial SSI, and one incision line necrosis. In the standard group, there were four wound dehiscences with deep SSI, three superficial SSIs, four incision line necroses, and one stump hematoma. The rates of perioperative mortality and amputation revision did not differ significantly between the NPWT and the standard groups (3% vs 4% and 4.3% vs 10%, respectively).
   Conclusions: Closed incision NPWT may decrease the incidence of wound complications in vascular patients undergoing major LEA. This held true even among a population that was potentially at higher risk. This therapy may be considered for use in lower extremity major amputations.
C1 [Chang, Heepeel; Maldonado, Thomas S.; Rockman, Caron B.; Cayne, Neal S.; Berland, Todd L.; Barfield, Michael E.; Jacobowitz, Glenn R.; Sadek, Mikel] NYU, Dept Surg, Div Vasc & Endovasc Surg, Langone Med Ctr, 530 First Ave,Ste 6F, New York, NY 10016 USA.
C3 NYU Langone Medical Center; New York University
RP Sadek, M (通讯作者)，NYU, Dept Surg, Div Vasc & Endovasc Surg, Langone Med Ctr, 530 First Ave,Ste 6F, New York, NY 10016 USA.
EM mikel.sadek@nyulangone.org
RI ; Rockman, Caron/PXB-2365-2026
OI Rockman, Caron/0000-0001-6955-4632; cayne, neal/0000-0003-4957-2723;
   Jacobowitz, Glenn/0000-0002-8136-2518
CR Agarwal A, 2019, PLAST RECONSTR SURG, V143, p21S, DOI 10.1097/PRS.0000000000005308
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NR 28
TC 27
Z9 29
U1 2
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAR
PY 2021
VL 73
IS 3
BP 1041
EP 1047
DI 10.1016/j.jvs.2020.07.061
EA FEB 2021
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA QZ7JO
UT WOS:000630898900069
PM 32707380
OA Bronze
DA 2026-07-24
ER

PT J
AU Anestiadou, E
   Stamiris, S
   Ioannidis, O
   Symeonidis, S
   Bitsianis, S
   Bougioukas, K
   Karagiannis, T
   Kotidis, E
   Pramateftakis, MG
   Mantzoros, I
   Cheva, A
   Geropoulos, G
   Chatzianestiadou, C
   Kaprianou, M
   Tserkezidis, F
   Angelopoulos, S
AF Anestiadou, Elissavet
   Stamiris, Stavros
   Ioannidis, Orestis
   Symeonidis, Savvas
   Bitsianis, Stefanos
   Bougioukas, Konstantinos
   Karagiannis, Thomas
   Kotidis, Efstathios
   Pramateftakis, Manousos-Georgios
   Mantzoros, Ioannis
   Cheva, Angeliki
   Geropoulos, Georgios
   Chatzianestiadou, Christiana
   Kaprianou, Magdalini
   Tserkezidis, Freiderikos
   Angelopoulos, Stamatios
TI Comparison of Negative Pressure Wound Therapy Systems and Conventional
   Non-Pressure Dressings on Surgical Site Infection Rate After Stoma
   Reversal: Systematic Review and Meta-Analysis of Randomized Controlled
   Trials
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE Negative Pressure Wound Therapy (NPWT); Surgical Site Infections (SSI);
   stoma reversal; meta-analysis; Randomized Controlled Trials (RCTs);
   colorectal surgery
ID CLOSURE; PREVENTION; OUTCOMES
AB Background/Objectives: Surgical Site Infections (SSIs) rank among the most common complications following stoma takedown and lead to increased morbidity, increased Length of Hospital Stay (LOS), and higher healthcare costs. Negative Pressure Wound Therapy (NPWT) systems have emerged as a promising option for optimizing wound management and minimizing SSI rates. This systematic review and meta-analysis compares postoperative outcomes of NPWT and conventional Non-Pressure Dressings following stoma reversal. Methods: A search of the literature published up to 1 September 2024 was conducted across MEDLINE/PubMed, and the Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus, as well as ClinicalTrials.gov. Only Randomized Controlled Trials (RCTs) were included. The primary outcome was SSI rate, while secondary outcomes included time to complete wound healing, LOS, and patient-reported wound cosmesis. Quality assessment was performed using the Cochrane Risk of Bias 2 (RoB 2) tool. The results were synthesized using means and Standard Deviations for continuous variables, counts and percentages for categorical variables, and presented as Odds Ratios (OR) or Mean Differences (MD) with 95% Confidence Intervals, using random or fixed effects models based on heterogeneity (I2). Results: Six RCTs, including 328 patients, were ultimately eligible for inclusion. No significant difference was revealed in SSI rates between the NPWT and conventional dressing groups (OR = 0.95; 95% CI: 0.27-3.29; p = 0.94; I2 = 38%). Time to complete wound healing was significantly lower in the NPWT group compared to conventional dressings (MD = -3.78 days; 95% CI: -6.29 to -1.27; p = 0.003). Two studies reported a lower rate of wound healing complications other than SSIs in the NPWT group (OR = 0.22; 95% CI: 0.05-1.09; p = 0.06). No substantial differences were observed in terms of LOS (MD = -0.02 days; 95% CI: -1.22 to 1.17; p = 0.97) and patient-reported wound cosmesis (SMD = 0.31; 95% CI: -0.49 to 1.11; p = 0.44). The review's limitations include potential risk of bias, variability in study designs, and heterogeneity between studies. Conclusions: NPWT contributes to improved wound management through reducing wound healing time compared to Non-Pressure Dressings after stoma reversal, although it does not appear to substantially impact SSI rates, LOS, or patient-assessed wound cosmesis. Further large-scale, multicenter RCTs are necessary to validate these results and identify patient populations most likely to benefit from NPWT application.
C1 [Anestiadou, Elissavet; Ioannidis, Orestis; Symeonidis, Savvas; Bitsianis, Stefanos; Kotidis, Efstathios; Pramateftakis, Manousos-Georgios; Mantzoros, Ioannis; Chatzianestiadou, Christiana; Kaprianou, Magdalini; Tserkezidis, Freiderikos; Angelopoulos, Stamatios] Aristotle Univ Thessaloniki, Gen Hosp George Papanikolaou, Dept Surg 4, Exochi 57010, Greece.
   [Stamiris, Stavros] 424 Gen Mil Hosp, Orthopaed Dept, Ring Rd West, Thessaloniki 56429, Greece.
   [Bougioukas, Konstantinos] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Hyg Social Prevent Med & Med Stat, Thessaloniki 54124, Greece.
   [Karagiannis, Thomas] Aristotle Univ Thessaloniki, Med Dept 2, Clin Res & Evidence Based Med Unit, Thessaloniki 54642, Greece.
   [Cheva, Angeliki] Aristotle Univ Thessaloniki, Fac Med, Pathol Dept, Thessaloniki 54124, Greece.
   [Geropoulos, Georgios] West Hertfordshire Teaching Hosp, Watford Gen Hosp, Dept Gen Surg, Watford WD180DH, England.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki; Watford General Hospital
RP Ioannidis, O (通讯作者)，Aristotle Univ Thessaloniki, Gen Hosp George Papanikolaou, Dept Surg 4, Exochi 57010, Greece.
EM elissavetxatz@gmail.com; st.stamiris@hotmail.com; telonakos@hotmail.com;
   simeonidissavvas@yahoo.com; sbitsiani@gmail.com; kbugiuk@yahoo.com;
   tkaragian@auth.gr; skotidis@gmail.com; mpramateftakis@hotmail.com;
   imanvol@gmail.com; antacheva@auth.gr; geropoulosgeo@gmail.com;
   cchristia@auth.gr; magdarenos@yahoo.gr; frtserkezidis@gmail.com;
   saggelopoulos@auth.gr
RI Cheva, Angeliki/HGB-6685-2022; Bitsianis, Stefanos/PLC-1440-2026;
   Bougioukas, Konstantinos/ABE-7673-2020; Karagiannis, Thomas/H-9476-2019;
   Stamiris, Stavros/JMB-4170-2023
OI Anestiadou, Elissavet/0000-0001-5650-7319; Bougioukas,
   Konstantinos/0000-0002-6533-1391; TSERKEZIDIS,
   FREIDERIKOS/0009-0009-8888-9740; Bitsianis,
   Stefanos/0000-0001-8281-1189; Karagiannis, Thomas/0000-0001-5242-0574;
   Ioannidis, Orestis/0000-0002-0861-8783; Stamiris,
   Stavros/0000-0001-8543-6791
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NR 63
TC 8
Z9 9
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2025
VL 14
IS 5
AR 1654
DI 10.3390/jcm14051654
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0BM8R
UT WOS:001443427800001
PM 40095625
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kirsner, RS
   Delhougne, G
   Searle, RJ
AF Kirsner, Robert S.
   Delhougne, Gary
   Searle, Richard J.
TI A Cost-Effectiveness Analysis Comparing Single-use and Traditional
   Negative Pressure Wound Therapy to Treat Chronic Venous and Diabetic
   Foot Ulcers
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE cost-effectiveness analysis; negative pressure wound therapy; venous leg
   ulcer; diabetic foot ulcer
ID LEG ULCERS; MINIMIZATION ANALYSIS; CARE; MANAGEMENT; OUTCOMES; BURDEN;
   HEALTH
AB Lower extremity ulcers such as venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs) have a major clinical and economic impact on patients and providers. PURPOSE: The purpose of this economic evaluation was to determine the cost-effectiveness of single-use negative pressure wound therapy (sNPWT) compared with traditional NPWT (tNPWT) for the treatment of VLUs and DFUs in the United States. METHODS: A Markov decision-analytic model was used to compare the incremental cost and ulcer weeks avoided for a time horizon of 12 and 26 weeks using lower extremity ulcer closure rates from a published randomized controlled trial (N = 161) that compared sNPWT with tNPWT. Treatment costs were extracted from a retrospective cost-minimization study of sNPWT and tNPWT from the payer perspective using US national 2016 Medicare claims data inflated to 2018 costs and multiplied by 7 to estimate the weekly costs of treatment for sNPWT and tNPWT. Two (2) arms of the model, tNPWT and sNPWT, were calculated separately for a combination of both VLU and DFU ulcer types. In this model, a hypothetical cohort of patients began in the Open ulcer health state, and at the end of each weekly cycle a proportion of the cohort moved into the Closed ulcer health state according to a constant transition probability. The costs over the defined timescale were summed to give a total cost of treatment for each arm of the model, and then the difference between the arms was calculated. Effectiveness was calculated by noting the incidence of healing at 12 and 26 weeks and the total number of open ulcer weeks; the incremental effectiveness was calculated as sNPWT effectiveness minus tNPWT effectiveness. Data were extracted to Excel spreadsheets and subjected to one-way sensitivity, scenario (where patients with unhealed ulcers were changed to standard care at 4 or 12 weeks), probabilistic, and threshold analyses. RESULTS: sNPWT was found to provide an expected cost saving of $7756 per patient and an expected reduction of 1.67 open ulcer weeks per patient over 12 weeks and a cost reduction of $15 749 and 5.31 open ulcer weeks over 26 weeks. Probabilistic analysis at 26 weeks showed 99.8% of the simulations resulted in sNPWT dominating tNPWT. Scenario analyses showed that sNPWT remained dominant over tNPWT (cost reductions over 26 weeks of $2536 and $7976 per patient, respectively). CONCLUSION: Using sNPWT for VLUs and DFUs is likely to be more cost-effective than tNPWT from the US payer perspective and may provide an opportunity for policymakers to reduce the economic burden of lower extremity ulcers.
C1 [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Univ Miami & Lospital & Clin, Wound Ctr,Dr Phillip Frost Dept Dermatol & Cutane, Miami, FL 33136 USA.
   [Delhougne, Gary] Smith & Nephew Inc, Hlth Econ & Market Access, Ft Worth, TX USA.
   [Searle, Richard J.] Smith & Nephew Med Ltd, HEOR, Kingston Upon Hull, N Humberside, England.
C3 University of Miami; Smith & Nephew; Smith & Nephew
RP Searle, RJ (通讯作者)，Smith & Nephew Med Ltd, 101 Hessle Rd, Kingston Upon Hull, N Humberside, England.
EM richard.searle@smith-nephew.com
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NR 27
TC 12
Z9 12
U1 0
U2 10
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD MAR
PY 2020
VL 66
IS 3
BP 30
EP 38
DI 10.25270/wmp.2020.3.3038
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA OR3BW
UT WOS:000589349900002
PM 32294054
DA 2026-07-24
ER

PT J
AU Lee, JH
   Kim, IK
   Kim, SE
AF Lee, Joon-Hyuk
   Kim, Il-Kug
   Kim, Sung-Eun
TI Perioperative Challenges in Oral Cavity Cancer Reconstruction in a
   Patient with Behçet's Disease: A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Beh & ccedil;et's disease; oral squamous cell carcinoma; floor-of-mouth
   cancer; anterolateral thigh free flap; pectoralis major myocutaneous
   flap; wound dehiscence; pathergy; vasculitis; fistula; head and neck
   reconstruction
AB Background/Objectives: Beh & ccedil;et's disease is a chronic relapsing multisystem inflammatory disorder characterized by recurrent mucocutaneous ulceration, vasculitis, and exaggerated inflammatory responses to minor trauma. These features may adversely affect wound healing after major head and neck oncologic reconstruction. This case report describes repeated wound breakdown after oral cavity reconstruction in a patient with Beh & ccedil;et's disease and advanced floor-of-mouth squamous cell carcinoma. Methods: A 51-year-old woman with Beh & ccedil;et's disease and T4N2bM0 squamous cell carcinoma involving the floor of the mouth and tongue underwent tumor resection followed by reconstruction of the oral cavity defect using a right anterolateral thigh perforator free flap. Subsequent surgical procedures included debridement of necrotic tissue, negative-pressure wound therapy, split-thickness skin grafting of the thigh donor site, and salvage tumor resection with pectoralis major myocutaneous flap reconstruction after tumor recurrence. Results: After the initial anterolateral thigh free flap reconstruction, flap perfusion was satisfactory in the immediate postoperative period; however, delayed marginal necrosis developed from the distal tongue-side flap margin, whereas the floor-of-mouth portion remained relatively stable. The right thigh donor site also developed progressive suture-line necrosis and wound dehiscence, requiring operative debridement, negative-pressure wound therapy, and split-thickness skin grafting. Although skin grafting achieved eventual donor-site coverage, partial graft necrosis and delayed secondary healing occurred. Persistent fistula and wound instability delayed postoperative radiotherapy, and recurrent floor-of-mouth squamous cell carcinoma subsequently developed approximately 6 months after the initial surgery. After salvage resection and pectoralis major myocutaneous flap reconstruction, the flap appeared viable at inset, but marginal ecchymosis, partial necrosis, and wound dehiscence again developed, requiring additional debridement, quilting sutures, and negative-pressure wound therapy. The wound gradually stabilized with staged wound management. Conclusions: This case illustrates a multifactorial pattern of repeated marginal wound breakdown after technically successful flap reconstruction in a patient with Beh & ccedil;et's disease. Beh & ccedil;et-related pathergy-like inflammation, vasculitis, and microcirculatory dysfunction may represent possible contributing mechanisms, but they were not directly proven in this patient. In oral cavity reconstruction, such wound instability may delay adjuvant therapy and adversely affect oncologic outcomes. Careful perioperative planning, close multidisciplinary coordination, meticulous tension-free closure, early recognition of wound compromise, and readiness for staged wound management are essential in patients with Beh & ccedil;et's disease undergoing major head and neck oncologic reconstruction.
C1 [Lee, Joon-Hyuk; Kim, Il-Kug; Kim, Sung-Eun] Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, Daegu 38541, South Korea.
C3 Yeungnam University
RP Kim, SE (通讯作者)，Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, Daegu 38541, South Korea.
EM mericle@naver.com; fdghfg26@naver.com
FX This research received no external funding.
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 12
PY 2026
VL 15
IS 12
AR 4562
DI 10.3390/jcm15124562
EA JUN 2026
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KA9NA
UT WOS:001802639000001
PM 42355730
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, JY
   Xu, RR
   Qian, J
   Cai, XC
AF Zhang, Jianyong
   Xu, Rongrong
   Qian, Jin
   Cai, Xuchao
TI Closed incision management with negative pressure wound therapy: a
   systematic review and meta-analysis of orthopedic trauma outcomes
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Review
DE Closed incisions; Conventional dressing; Negative pressure wound
   treatment; Orthopedic trauma surgery; Surgical site infection; Wound
   dehiscence
ID SURGICAL SITE INFECTION; HIGH-RISK PATIENTS; KNEE ARTHROPLASTY; FRACTURE
   SURGERY; COMPLICATIONS; DRESSINGS; HIP; IMPACT
AB We conducted a systematic review and meta-analysis to evaluate the effectiveness of negative pressure wound therapy (NPWT ) compared to traditional wound care for closed incisions following orthopedic trauma surgery. Wound complications, including surgical site infections (SSIs) and wound dehiscence, are common in orthopedic trauma surgery, affecting a significant portion of patients. To address this, we analyzed data from 3994 participants across 15 trials, with 2045 patients receiving NPWT and 1949 receiving conventional wound dressings. Our results show that NPWT was associated with reduced deep surgical site infection (OR, 0.60; 95% CI, 0.45-0.81, P = 0.0005), superficial surgical site infection (OR, 0.34; 95% CI, 0.19-0.61, P = 0.003), and wound dehiscence (OR, 0.41; 95% CI, 0.21-0.80, P = 0.009) compared to traditional dressings. Additionally, NPWT was associated with a reduction in hospital stays (MD, 0.89; 95% CI, 0.49-1.30, P = 0.0001). However, the clinical significance of this modest reduction should be interpreted cautiously given the high heterogeneity (I-2 = 92%) observed in this outcome. Despite these positive outcomes, the study's limitations, such as the lack of long-term follow-up, the potential for publication bias, moderate to high heterogeneity in some outcomes, and the inclusion of both randomized and non-randomized studies, suggest that additional high-quality randomized controlled trials are necessary to fully validate the long-term effectiveness and safety of NPWT in this context.
C1 [Zhang, Jianyong] Hangzhou First Peoples Hosp, Hangzhou Rehabil Hosp, Xiasha Campus, Hangzhou, Peoples R China.
   [Xu, Rongrong] Qingdao No 8 Peoples Hosp, Orthoped & Sports Med Dept, Qingdao, Peoples R China.
   [Qian, Jin] WestLake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Orthoped, Hangzhou, Peoples R China.
   [Cai, Xuchao] Hangzhou First Peoples Hosp, Hangzhou Geriatr Hosp, Wound Repair Dept, Chengbei Campus, Hangzhou, Peoples R China.
C3 Westlake University
RP Zhang, JY (通讯作者)，Hangzhou First Peoples Hosp, Hangzhou Rehabil Hosp, Xiasha Campus, Hangzhou, Peoples R China.; Cai, XC (通讯作者)，Hangzhou First Peoples Hosp, Hangzhou Geriatr Hosp, Wound Repair Dept, Chengbei Campus, Hangzhou, Peoples R China.
EM 154216448@qq.com; 15318731378@189.cn; qian_godspeed@163.com;
   chaoxuc@163.com
RI ; Xu, Rongrong/JXY-1470-2024
OI , Cai/0009-0005-0510-0021; 
FU Hangzhou Biopharmaceutical and Health Industry Development Support
   Technology Special Program [2024WJC186]
FX Hangzhou Biopharmaceutical and Health Industry Development Support
   Technology Special Program (2024WJC186)
CR Benirschke SK, 2004, J ORTHOP TRAUMA, V18, P1, DOI 10.1097/00005131-200401000-00001
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   Cooper HJ, 2018, INJURY, V49, P386, DOI 10.1016/j.injury.2017.11.010
   Cooper HJ, 2016, J ARTHROPLASTY, V31, P1047, DOI 10.1016/j.arth.2015.11.010
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NR 32
TC 0
Z9 1
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 23
PY 2025
VL 26
IS 1
AR 991
DI 10.1186/s12891-025-08986-1
PG 12
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 8YR7A
UT WOS:001600488800003
PM 41131516
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Facchin, F
   Pagani, A
   Marchica, P
   Pandis, L
   Scarpa, C
   Brambullo, T
   Bassetto, F
   Vindigni, V
AF Facchin, Federico
   Pagani, Andrea
   Marchica, Paolo
   Pandis, Laura
   Scarpa, Carlotta
   Brambullo, Tito
   Bassetto, Franco
   Vindigni, Vincenzo
TI The Role of Portable Incisional Negative Pressure Wound Therapy (piNPWT)
   in Reducing Local Complications of Post-bariatric Brachioplasty: A
   Case-Control Study
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Body-contouring; Post-bariatric patients; Surgical site complications;
   Obesity; Brachioplasty; Wound care
AB Background Due to the great impact of bariatric surgery on the overweight epidemic, the number of post-bariatric body-contouring procedures is constantly increasing worldwide. The portable incisional negative pressure wound therapy (piNPWT) is a promising medical device for accelerating wounds closure and controlling post-operative complication, which have been shown promising results in post-bariatric population. We aimed to evaluate the role of piNPWT in optimizing wound healing and controlling post-operative complications after a post-bariatric brachioplasty.
   Patients and Methods 26 post-bariatric female patients who underwent a brachioplasty followed by either a piNPWT (14 cases) or a standard wound treatment (12 controls) were analyzed. The number of post-operative dressing changes, the rate of local post-operative complications (re-operation, hematoma and serosa development, dehiscence and necrosis), the time to dry as well as the scar quality and hospitalization length were evaluated.
   Results None of the patients prematurely stopped treatment with piNPWT due to intolerance. The piNPWT patient group showed a significant lower healing time as well as a significant reduction of the number of post-operative dressing changes and hospital stay. Despite the scarring process was excellent from the functional point of view in the long term, we noticed a higher rate of hyperchromic scarring at 90 days after surgery.
   Conclusion The piNPWT is a cost-effective and user-friendly medical tool that increase and promote wound healing. We suggest the use of this device in post-bariatric patients who undergo a brachioplasty, especially if there is the need to minimize the number of post-operative dressing changes.
C1 [Facchin, Federico; Marchica, Paolo; Pandis, Laura; Scarpa, Carlotta; Brambullo, Tito; Bassetto, Franco; Vindigni, Vincenzo] Univ Padua, Plast & Reconstruct Surg Unit, Via Nicolo Giustininani 2, I-35128 Padua, Italy.
   [Pagani, Andrea] Tech Univ Munich, Clin & Policlin Plast & Hand Surg, Ismaninger Str 22, D-81675 Munich, Germany.
C3 University of Padua; Technical University of Munich
RP Facchin, F (通讯作者)，Univ Padua, Plast & Reconstruct Surg Unit, Via Nicolo Giustininani 2, I-35128 Padua, Italy.
EM federicofacchin@yahoo.it; andrea.pagani@studenti.unipd.it;
   paolomarchica91@gmail.com; laura.pandis@aopd.veneto.it;
   carlotta.scarpa@unipd.it; tito.brambullo@aopd.veneto.it;
   franco.bassetto@unipd.it; vincenzo.vindigni@unipd.it
RI Marchica, Paolo/NQF-8611-2025; Brambullo, Tito/AAZ-2332-2020; Scarpa,
   Carlotta/HJG-7233-2022; Vindigni, Vincenzo/K-5059-2016; Facchin,
   Federico/GLN-4990-2022
OI Marchica, Paolo/0000-0002-2108-2979; Brambullo,
   Tito/0000-0002-1041-9660; Facchin, Federico/0000-0002-6695-1103
FU Universita` degli Studi di Padova
FX Open Access funding provided by Universita` degli Studi di Padova. No
   funding has been received in support of the paper
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NR 37
TC 7
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD AUG
PY 2021
VL 45
IS 4
BP 1653
EP 1659
DI 10.1007/s00266-020-02122-1
EA JAN 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TQ5EK
UT WOS:000609999600001
PM 33481062
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Bazalinski, D
   Wiech, P
   Kaczmarska, D
   Salacinska, I
   Kózka, M
AF Bazalinski, Dariusz
   Wiech, Pawel
   Kaczmarska, Dorota
   Salacinska, Izabela
   Kozka, Maria
TI Use of controlled negative pressure in management of phlegmon caused by
   fulminant complication of pressure wound A case report
SO MEDICINE
LA English
DT Article
DE negative pressure wound therapy; phlegmon; pressure wound; tissue
   cleansing
ID THERAPY; ULCERS; CARE
AB Rationale: Effective wound healing depends on the adequate choice of the wound cleansing method, to enable rapid removal of necrotic tissue. Negative pressure wound therapy (NPWT) is an effective non-invasive technique for management of wounds of varied aetiology, including deep tissue injuries caused by pressure.
   Patient concerns: This article discusses a case of an 82-year-old female receiving hospice care at home owing to progressing untreated thoracic spinal stenosis, bedridden for 4 years, incapable of self-care.
   Diagnoses: Three fulminant pressure wounds, 50cm(2) each, with signs of undermining, Stage II/IV according to National Pressure Ulcer Advisory Panel, were identified in the area of the sacrum and the right and left trochanter. Despite measures used to prevent pressure sores, and nutritional supplementation, two months later a fourth pressure ulcer involving subcutaneous tissue was identified in the area of the right sciatic tuber, accompanied with signs of systemic inflammatory response, as well as massive phlegmon and lesion in the ischial bone.
   Interventions: As previously applied treatments (surgical necrectomy, biological therapy - Lucilia Sericata maggots, autolysis, pharmacological therapy) proved ineffective, NPWT was experimentally administered to evacuate exudate and to cleanse the wound.
   Outcomes: Application of negative pressure during a 42-day therapy allowed significantly faster cleansing of the wound. The pressure wounds was significantly reduced in size, and necrotic tissue was removed from the sciatic tuber, which ultimately was covered with granulation tissue.
   Lessons: Controlled negative pressure can successfully be used in the process of cleansing an infected pressure wound to safely remove exudate and to minimise local inflammation. Administration of controlled negative pressure is an effective and safe method in the process of cleansing an infected pressure wound.
C1 [Bazalinski, Dariusz; Wiech, Pawel; Salacinska, Izabela] Univ Rzeszow, Dept Med, Inst Nursing & Hlth Sci, Rzeszow, Poland.
   [Bazalinski, Dariusz; Kaczmarska, Dorota] Specialist Hosp Podkarpackie Oncol Ctr Brzozow, Brzozow, Poland.
   [Kozka, Maria] Jagiellonian Univ, Coll Med, Fac Hlth Sci, Dept Clin Nursing, Krakow, Poland.
C3 University of Rzeszow; Jagiellonian University; Collegium Medicum
   Jagiellonian University
RP Wiech, P (通讯作者)，Uniwers Rzeszow, Inst Nursin & Hlth Sci, Al Mjr W Kopisto 2 A, PL-35310 Rzeszow, Poland.
EM p.k.wiech@gmail.com
RI bazaliński, dariusz/AFN-7652-2022; Sałacińska, Izabela/V-8499-2019
OI bazaliński, dariusz/0000-0003-1717-1319; Więch,
   Paweł/0000-0002-0101-1030; Sałacińska, Izabela/0000-0003-1752-7610
FU Regional Operational Programme for the Podkarpackie Province
   [UDA-RPPK.01.03.00-18-004/12-00]
FX The study was performed as part of the project "Centre for Innovative
   Research in Medical and Natural Sciences" implemented by the University
   of Rzeszow, co-financed in the framework of 2007-2013 Regional
   Operational Programme for the Podkarpackie Province, contract number
   UDA-RPPK.01.03.00-18-004/12-00.
CR Apelqvist J, 2017, J WOUND CARE, V26, P1
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NR 20
TC 6
Z9 7
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2018
VL 97
IS 28
AR e11319
DI 10.1097/MD.0000000000011319
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GO0AE
UT WOS:000439577500017
PM 29995766
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Xu, Y
   Shao, S
   Gong, ZZ
   Ri, H
   Xu, ZH
   Kang, HN
   Shan, Y
   Amadou, BH
   Ren, YY
   Zhang, F
   Chen, X
AF Xu, Yang
   Shao, Shuai
   Gong, ZeZhong
   Ri, HyokJu
   Xu, ZhaoHui
   Kang, HaoNan
   Shan, Yan
   Amadou, Boureima Hamidou
   Ren, YanYing
   Zhang, Fan
   Chen, Xin
TI Efficacy of prophylactic negative pressure wound therapy after open
   ventral hernia repair: a systematic review meta-analysis
SO BMC SURGERY
LA English
DT Review
DE Ventral hernia; Surgical site occurrences; OVHR; NPWT
ID MANAGEMENT; OUTCOMES; INFECTION; DRESSINGS; REDUCTION; COST
AB Introduction The susceptibility to surgical site occurrence (SSO) is high following ventral hernia repair (VHR) surgery. SSO severely increases the physical and mental burden on patients. The main purpose of this review was to analyze the efficacy of negative pressure wound therapy (NPWT) after open VHR(OVHR) and explore benefits to patients.Methods The Cochrane Library, PubMed, and Embase databases were searched from the date of establishment to 15 October 2022. All randomized controlled trials and retrospective cohort studies comparing NPWT with standard dressings after OVHR were included. The Revman 5.4 software recommended by Cochrane and the STATA16 software were used in this meta-analysis.Results Fifteen studies (involving 1666 patients) were identified and included in the meta-analysis, with 821 patients receiving NPWT. Overall, the incidence rate of SSO in the NPWT group was lower compared to the control group (odds ratio [OR] = 0.44; 95% confidence interval [CI] = 0.21-0.93; I-2 = 86%; P = 0.03). The occurrence rate of surgical site infection (SSI; OR = 0.51; 95% CI = 0.38-0.68, P < 0.001), wound dehiscence (OR = 0.64; 95% CI = 0. 43-0.96; P = 0.03), and hernia recurrence (OR = 0.51; 95% CI = 0.28-0.91, P = 0.02) was also lowered. There was no significant difference in seroma (OR = 0.76; 95% CI = 0.54-1.06; P = 0.11), hematoma (OR = 0.53; 95% CI = 0.25-1.11; P = 0.09), or skin necrosis (OR = 0.83; 95% CI = 0.47-1.46; P = 0.52).Conclusion NPWT can effectively decrease the occurrence of SSO, SSI wound dehiscence and hernia recurrence and should be considered following OVHR.
C1 [Xu, Yang; Shao, Shuai; Gong, ZeZhong; Ri, HyokJu; Xu, ZhaoHui; Kang, HaoNan; Shan, Yan; Amadou, Boureima Hamidou; Ren, YanYing; Zhang, Fan; Chen, Xin] Dalian Med Univ, Dept Hernia & Colorectal Surg, Hosp 2, Dalian 116023, Peoples R China.
   [Ri, HyokJu] Hosp Pyongyang Med Coll, Dept Colorectal Surg, Pyongyang 999093, North Korea.
C3 Dalian Medical University
RP Chen, X (通讯作者)，Dalian Med Univ, Dept Hernia & Colorectal Surg, Hosp 2, Dalian 116023, Peoples R China.
EM chenxincjz@gmail.com
RI ; shao, shuai/KVA-8071-2024
OI Ri, HyokJu/0000-0002-5172-7029; 徐, 阳/0000-0002-6923-8274; 
FU Second Hospital of Dalian Medical University [2022JCXKYB01,
   2022JCXKYB20]; Dalian Medical Science Research Project [2012023]
FX <STRONG> </STRONG>This work was supported by the "1 + X" program for the
   Clinical Competency Enhancement -Interdisciplinary Innovation
   Project,The Second Hospital of Dalian Medical University (2022JCXKYB01,
   2022JCXKYB20), and the Dalian Medical Science Research Project
   (2012023).
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NR 47
TC 6
Z9 9
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 11
PY 2023
VL 23
IS 1
AR 374
DI 10.1186/s12893-023-02280-4
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CF0G4
UT WOS:001123712500001
PM 38082353
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hahn, HM
   Lee, DH
   Lee, IJ
AF Hahn, Hyung Min
   Lee, Dong Hwan
   Lee, Il Jae
TI Ready-to-Use Micronized Human Acellular Dermal Matrix to Accelerate
   Wound Healing in Diabetic Foot Ulcers: A Prospective Randomized Pilot
   Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal matrix; advanced therapy; cellular and/or tissue-based
   product; diabetic foot ulcer; micronized human acellular dermal matrix;
   negative-pressure wound therapy; wound healing
ID LOWER-EXTREMITIES; THERAPY
AB OBJECTIVE: To examine and report clinical outcomes of a ready-to-use micronized dermal matrix for diabetic foot ulcers (DFUs) and compare it to treatment with conventional negative-pressure wound therapy (NPWT) only.
   METHODS: The researchers randomly allocated 30 DFUsWagner grade 2 or higher from 30 adult patients into two groups. The control group (n = 15) was treated with conventional NPWT, and the experimental group (n = 15) was treated with micronized dermal matrix and NPWT. The researchers evaluated the following outcomes: granulation tissue formation, proportion of patients with closed or granulated wounds at 42 and 120 days, achievement of complete wound healing in the 6 months of follow-up, and intervals from enrollment to final surgical procedures.
   RESULTS: All 15 wounds treated with the micronized matrix showed healthy granulation tissue without noticeable complications during follow-up. At 42 days, 46.7% of wounds in the experimental group had closed compared with 28.6% in the conventional NPWT group (P =.007). At 120 days, 86.7% of the experimental group had completely closed wounds, compared with 57.1% in the conventional therapy group (P =.040). During the 6-month follow-up period, 93.3% of the experimental group achieved complete wound healing compared with 85.7% of the conventional therapy group (P =.468).
   CONCLUSIONS: The healing outcomes for DFUs in the experimental group were superior when micronized matrix treatment was combined with NPWT.
C1 [Hahn, Hyung Min] Ajou Univ, Sch Med, Suwon, South Korea.
   [Lee, Dong Hwan; Lee, Il Jae] Ajou Univ, Dept Plast & Reconstruct Surgery, Suwon, South Korea.
C3 Ajou University; Ajou University
RP Hahn, HM (通讯作者)，Ajou Univ, Sch Med, Suwon, South Korea.
FU Korea Health Industry Development Institute grant
FX The authors thank Editage (www.editage.co.kr) for English language
   editing. This research was supported by a Korea Health Industry
   Development Institute grant to Ajou UniversityMedical Center. The
   authors have disclosed no other financial relationships related to this
   article. Submitted May 28, 2020; accepted in revised form September 3,
   2020.
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NR 15
TC 17
Z9 18
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAY
PY 2021
VL 34
IS 5
BP 1
EP 6
DI 10.1097/01.ASW.0000741512.57300.6d
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA J6167
UT WOS:001627729200001
PM 33852465
DA 2026-07-24
ER

PT J
AU Losa-Palacios, S
   Achaerandio-de Nova, A
   Restrepo-Pérez, M
   Gerónimo-Pardo, M
AF Losa-Palacios, Sergio
   Achaerandio-de Nova, Ainara
   Restrepo-Perez, Marcela
   Geronimo-Pardo, Manuel
TI Uncooperative Patient With an Infected Elbow Osteosynthesis: Alternative
   Management With Topical Sevoflurane
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE osteosynthesis; negative pressure wound therapy; sevoflurane; infection;
   trauma; complication; surgical wound
ID PRESSURE WOUND THERAPY; PROSTHESIS RETENTION; JOINT INFECTION;
   DEBRIDEMENT; CLOSURE; ANTIBIOTICS; LIDOCAINE; NONUNION; IMPACT; ULCER
AB Introduction. Treatment of an infected osteosynthesis is usually a complicated process, with its complexity increasing when unforeseen situations appear. Typically, the therapeutic management of such situations is challenging because they are not anticipated in the medical literature, and physicians have to look for and adapt novel solutions to a specific patient condition. Case Report. A 41-year-old, uncooperative, homeless man presented to the emergency room with a left olecranon fracture. After planned surgery, the surgical wound became infected with methicillin-sensitive Staphylococcus aureus because treatment took place in an unhygienic outpatient hospital setting. The patient refused to remain in the hospital and also failed to complete antibiotic courses prescribed (culture-guided rifampicin 600 mg daily plus levofloxacin soo mg daily). Instead of removing the osteosynthesis material, the infection was treated successfully by repeated applications of 5 mL of sevoflurane into the surgical wound. Subsequently, wound healing was achieved with a combination of a brief course of negative pressure wound therapy (NPWT), use of silver-impregnated dressings, and irrigation of the wound with sevoflurane. Sevoflurane also provided topical analgesic to ameliorate the pain caused by removing the NPWT sponge. Interestingly, despite extremely poor compliance by the patient to all standard treatment regimens, and the clinical decision to retain the implant, the infection was resolved and the fracture consolidated. Conclusions. Local application of sevoflurane in the wound bed appears to exhibit analgesic, antimicrobial, and positive healing effects. It could be a promising alternative treatment to be included as a therapeutic option for wound care.
C1 [Losa-Palacios, Sergio; Achaerandio-de Nova, Ainara; Restrepo-Perez, Marcela] Complejo Hosp Univ Albacete, Dept Orthoped Surg, Albacete, Spain.
   [Geronimo-Pardo, Manuel] Complejo Hosp Univ Albacete, Dept Anesthesiol, Calle Hermanos Falco 37, Albacete 02006, Spain.
RP Gerónimo-Pardo, M (通讯作者)，Complejo Hosp Univ Albacete, Dept Anesthesiol, Calle Hermanos Falco 37, Albacete 02006, Spain.
EM sergepu@hotmail.com
RI Gerónimo Pardo, Manuel/AGD-8316-2022
OI Gerónimo Pardo, Manuel/0000-0001-9911-7572; Achaerandio de Nova,
   Ainara/0000-0002-7663-3977
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NR 35
TC 4
Z9 5
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2019
VL 31
IS 10
BP E68
EP E72
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KB9XQ
UT WOS:000506841400002
PM 31730517
DA 2026-07-24
ER

PT J
AU Cheng, L
   Du, WL
   Zhang, Y
   Chen, Z
   Shen, YM
AF Cheng, Lin
   Du, Wei-Li
   Zhang, Ying
   Chen, Zhong
   Shen, Yu-ming
TI Application of Staged Negative Pressure Wound Therapy and Flap Surgery
   for Infection Control After Patellar Internal Fixation Surgery
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Infection; internal fixation; NPWT; patella; pedicled flaps
ID PERFORATOR FLAP; RECONSTRUCTION; KNEE; COMPLICATIONS; REOPERATION;
   FRACTURES; NONUNION; DEFECTS
AB The anatomic position of the patella is superficial, making it vulnerable to injuries. Treatment of patella infection after internal fixation surgery remains a big challenge due to minimal soft tissue coverage and vital tissue exposure. Forty-two patients aged 10 to 59 years were admitted to the institution's burn unit between January 2010 and December 2019. Each presented with infection after patellar fracture surgery. Twenty-seven infections were superficial, whereas 15 were deep with pyogenous arthritis of the knee. Negative pressure wound therapy (NPWT) was applied after radical debridement to remove necrotic subcutaneous tissues and internal fixation devices. In addition, cases with septic arthritis were irrigated continuously with normal saline. After 5 to 10 days of NPWT treatment and irrigation, wound infection was well controlled. Afterward, 42 wounds were resurfaced with pedicled flaps, the 42 patients received 17 reverse-flow anterolateral thigh (ALT) perforator flap, 12 medial sural artery perforator flaps, 7 gastrocnemius musculocutaneous flaps, as well as 6 saphenous artery flaps. Thirty-seven flaps survived uneventfully. However, 3 flaps developed venous congestion in the distal end. Two flaps developed tip necrosis. All patients were followed up between 3 and 48 months. Infection beneath the flap occurred in 3 patients and healed after an additional debridement surgery. The staged NPWT and flap surgery strategy focus on thorough debridement and immediate internal fixation devices removal, effective fracture fixation, efficient NPWT application, targeted administration of antibiotics, and adequate soft tissue coverage. This study established that the procedure was effective in infection control after patellar internal fixation surgery.
C1 [Cheng, Lin; Du, Wei-Li; Zhang, Ying; Chen, Zhong; Shen, Yu-ming] Beijing Jishuitan Hosp, Dept Burns & Plast Surg, Beijing 100035, Peoples R China.
RP Shen, YM (通讯作者)，Beijing Jishuitan Hosp, Dept Burns & Plast Surg, Beijing 100035, Peoples R China.
EM chenglin5407@126.com; 670816419@qq.com; 542452728@qq.com;
   zhangcongjst@126.com; shenyumingjst@126.com
CR Anand S, 2008, INJURY, V39, P480, DOI 10.1016/j.injury.2007.10.032
   Bowler PG, 2018, J WOUND CARE, V27, P273, DOI 10.12968/jowc.2018.27.5.273
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   Lee SY, 2011, ORTHOPEDICS, V34, P478, DOI 10.3928/01477447-20110427-27
   Ling BM, 2018, J BONE JOINT SURG AM, V100, P211, DOI 10.2106/JBJS.16.01401
   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
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   Petrie J, 2013, J KNEE SURG, V26, P309, DOI 10.1055/s-0033-1353990
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NR 22
TC 0
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JAN-FEB
PY 2024
VL 35
IS 1
BP 74
EP e78
DI 10.1097/SCS.0000000000009854
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HH5K0
UT WOS:001158612900026
PM 37982783
DA 2026-07-24
ER

PT J
AU Namgoong, S
   Jung, SY
   Han, SK
   Kim, AR
   Dhong, ES
AF Namgoong, Sik
   Jung, Su-Young
   Han, Seung-Kyu
   Kim, Ae-Ree
   Dhong, Eun-Sang
TI Clinical experience with surgical debridement and simultaneous meshed
   skin grafts in treating biofilm-associated infection: an exploratory
   retrospective pilot study
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Biofilm; diabetic ulcer; negative pressure wound therapy; skin graft;
   surgical debridement
ID IN-VITRO; WOUNDS
AB Current treatment guidelines for biofilm-associated infections (BAI) recommend repeated sharp/surgical debridement followed by treatment with antimicrobial agents until the wound becomes self-sustaining in terms of a positive wound-healing trajectory. However, complete removal of a biofilm is unlikely, and biofilms reform rapidly. We have treated BAI in patients with chronic diabetic ulcers using a meshed skin graft combined with negative pressure wound therapy (NPWT) immediately after surgical debridement, rather than waiting until the development of clean and healthy granulation tissue; the purpose of this exploratory study was to report the clinical results of this treatment strategy. This retrospective study included 75 patients with chronic diabetic ulcers who were treated for BAI by using surgical debridement, simultaneous meshed skin grafts, and NPWT. Healing time along with the percentage of complete wound closure within 12?weeks were evaluated; bacteria isolated from the wounds and their relation to the wound healing rate were investigated. All 75 wounds healed successfully, and the mean time for complete wound healing was 3.5???1.8?weeks. In particular, 76% of wounds healed uneventfully without graft loss. A mean of 3.3 bacterial colonies/wound were isolated; however, no significant difference in wound healing was observed between the monomicrobial and polymicrobial groups. This exploratory study suggests that surgical debridement and simultaneous meshed skin grafts combined with NPWT may be successfully used to combat BAI in patients with chronic diabetic ulcers. We look forward to larger pivotal studies to confirm or refute these initially promising findings.
C1 [Namgoong, Sik; Han, Seung-Kyu; Dhong, Eun-Sang] Korea Univ Coll Med, Dept Plast Surg, Seoul, South Korea.
   [Jung, Su-Young] Armed Forces Capital Hosp, Dept Plast Surg, Seongnam, South Korea.
   [Kim, Ae-Ree] Korea Univ, Dept Pathol, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Dept Plast Surg, Guro Hosp, 148 Guro Dong, Seoul 08308, South Korea.
EM pshan@kumc.or.kr
RI Namgoong, Sik/ABB-7842-2021
OI Namgoong, Sik/0000-0002-4200-7089; Dhong, Eun Sang/0000-0002-7521-0518
CR Beele H, 2010, INT WOUND J, V7, P262, DOI 10.1111/j.1742-481X.2010.00669.x
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NR 25
TC 18
Z9 24
U1 1
U2 11
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JAN 2
PY 2020
VL 54
IS 1
BP 47
EP 54
DI 10.1080/2000656X.2019.1673170
EA OCT 2019
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KQ5QP
UT WOS:000488411100001
PM 31575315
OA gold
DA 2026-07-24
ER

PT J
AU Zheng, JX
   Xie, DN
   Wu, MY
   Xu, HT
   Lin, SY
   Dong, LL
AF Zheng, Jiaxing
   Xie, Danna
   Wu, Minyu
   Xu, Hongtao
   Lin, Siyin
   Dong, Lili
TI Effects of non-pharmacological interventions on ulcer healing in
   patients with diabetic foot: a network meta-analysis of randomized
   controlled trials
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetic foot ulcer; healing rate; healing time; network meta-analysis;
   non-pharmacological intervention; nursing; wound care
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; DOUBLE-BLIND;
   EFFICACY; MULTICENTER; MANAGEMENT; CARE
AB Background Diabetic Foot Ulcers are a serious complication of diabetes, and the clinical treatment is challenging. In this study, network meta-analysis was used to evaluate the effect of different non-drug interventions on Diabetic Foot Ulcer healing and provide evidence to support clinical decision-making. Methods Data sources: 8 databases, including PubMed, Embase, Cochrane, WOS, CNKI, Wanfang Data, CBM, and VIP, were systematically searched. Literature screening: According to the principle of PICOS, two researchers independently screened. Quality evaluation: Two researchers independently used the Cochrane bias risk assessment tool (RoB 2.0) to evaluate the risk of bias. Statistical analysis: by NMA of the random effects model under the framework of frequency. Results A total of 24 randomized controlled trials involving 15 types of interventions were included. The overall quality of the included literature was moderate. The results of NMA showed that Negative Pressure Wound Therapy + Standard Care had the best effect on 12-week healing rate. Compared with Standard Care, Gas Therapy+ Dressing Therapy + Standard Care had the best healing time. Conclusion Negative Pressure Wound Therapy + Standard Care may be more beneficial for improving the 12-week healing rate of Diabetic Foot Ulcer, while Gas Therapy + Dressing Therapy + Standard Care may show potential advantages in shortening healing time. However, these results rely on a limited number of small-sample studies with wide confidence intervals, indicating limited certainty of evidence. Consequently, the SUCRA rankings should be interpreted with caution as they are primarily exploratory; further high-quality RCTs are required to confirm these findings.
C1 [Zheng, Jiaxing; Xie, Danna; Wu, Minyu; Xu, Hongtao; Dong, Lili] Shantou Univ, Med Coll, Affiliated Hosp 2, Shantou, Peoples R China.
   [Zheng, Jiaxing; Xu, Hongtao; Lin, Siyin] Shantou Univ, Med Coll, Shantou, Peoples R China.
   [Lin, Siyin] Shantou Univ, Canc Hosp, Coll Med, Shantou, Peoples R China.
C3 Shantou University; Shantou University; Shantou University
RP Dong, LL (通讯作者)，Shantou Univ, Med Coll, Affiliated Hosp 2, Shantou, Peoples R China.; Lin, SY (通讯作者)，Shantou Univ, Med Coll, Shantou, Peoples R China.; Lin, SY (通讯作者)，Shantou Univ, Canc Hosp, Coll Med, Shantou, Peoples R China.
EM 928840063@qq.com; Dll13531279671@163.com
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NR 70
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 26
PY 2026
VL 17
AR 1811595
DI 10.3389/fendo.2026.1811595
EA MAR 2026
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GG8YG
UT WOS:001736106900001
PM 41970969
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jelinek, P
   Hrubovcak, J
   Hajovsky, R
   Velicka, J
   Pies, M
AF Jelinek, Petr
   Hrubovcak, Jan
   Hajovsky, Radovan
   Velicka, Jan
   Pies, Martin
TI Application of Closed Incision Negative Pressure Wound Therapy in
   Ventral Hernia Repair Surgery Using a Polypropylene Mesh: A Randomized
   Clinical Trial
SO MEDICINA-LITHUANIA
LA English
DT Article
DE negative pressure therapy; polypropylene mesh; randomized trial; wound
   infection; aseptic wounds; ventral hernia repair
AB Background and Objectives: Surgical site infections (SSIs) are a significant complication following ventral hernia repair, potentially leading to prolonged hospital stays and increased morbidity. This study aimed to evaluate whether closed incision negative pressure wound therapy (ciNPWT) reduces the incidence of SSI after ventral hernia repair with polypropylene mesh compared to standard wound care. Materials and Methods: A randomized study was conducted with 100 patients undergoing ventral hernia repair using a polypropylene mesh. Participants were divided into two groups: a control group (n=50), which received standard sterile gauze dressing with an iodine-based disinfectant, and an intervention group (n=50), treated with the ciNPWT system (Vivano (R) by HARTMANN) for 5 days postoperatively. The primary outcome was the incidence of SSI within one year after surgery. Secondary outcomes included the influence of factors such as age, sex, smoking status, and hernia size on SSI occurrence. The study was approved by the Ethics Committee at the University Hospital Ostrava, adhering to the ethical standards of the Helsinki Declaration. Results: The incidence of SSI was lower in the ciNPWT group compared to the standard care group (4% vs. 12%), though this difference did not reach statistical significance. No significant effect of sex or smoking status on SSI was observed. The control group had a shorter mean length of hospital stay. Larger hernias in the non-ciNPWT group were more prone to SSIs, as expected. Conclusions: Although limited by a small sample size, the findings suggest that ciNPWT may be associated with a reduced rate of SSI following ventral hernia repair. Further studies with larger populations are needed to confirm these results.
C1 [Jelinek, Petr; Hrubovcak, Jan] Univ Hosp Ostrava, Dept Surg, 17 Listopadu 1790-5, Ostrava 70800, Czech Republic.
   [Jelinek, Petr; Hrubovcak, Jan] Univ Ostrava, Fac Med, Dept Surg Studies, Syllabova 19, Ostrava 70300, Czech Republic.
   [Hajovsky, Radovan; Velicka, Jan; Pies, Martin] VSB Tech Univ Ostrava, Fac Elect Engn & Comp Sci, Dept Cybernet & Biomed Engn, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Technical University
   of Ostrava
RP Jelinek, P (通讯作者)，Univ Hosp Ostrava, Dept Surg, 17 Listopadu 1790-5, Ostrava 70800, Czech Republic.; Jelinek, P (通讯作者)，Univ Ostrava, Fac Med, Dept Surg Studies, Syllabova 19, Ostrava 70300, Czech Republic.; Pies, M (通讯作者)，VSB Tech Univ Ostrava, Fac Elect Engn & Comp Sci, Dept Cybernet & Biomed Engn, 17 Listopadu 2172-15, Ostrava 70800, Czech Republic.
EM petr.jelinek@fno.cz; jan.hrubovcak@fno.cz; radovan.hajovsky@vsb.cz;
   jan.velicka@vsb.cz; martin.pies@vsb.cz
RI ; Pies, Martin/K-1249-2013; Velicka, Jan/HTR-2050-2023
OI Jelinek, Petr/0000-0002-3988-024X; Pies, Martin/0000-0001-8029-1669;
   Hrubovcak, jan/0009-0002-0993-2472; Hajovsky,
   Radovan/0000-0001-7609-1787; Velicka, Jan/0000-0003-1893-8729
FU Ministry of Health of the Czech Republic; Ministry of Education of the
   Czech Republic [SP2024/021]; European Union under the REFRESH - Research
   Excellence For REgion Sustainability and High-tech Industries
   [CZ.10.03.01/00/22_003/0000048];  [01/RVO-FNOs/2021]
FX Supported by the project Institutional support of the Ministry of Health
   of the Czech Republic (01/RVO-FNOs/2021). This article was supported by
   the Ministry of Education of the Czech Republic (Project No.
   SP2024/021). This article was co-funded with the financial support of
   the European Union under the REFRESH - Research Excellence For REgion
   Sustainability and High-tech Industries project number
   CZ.10.03.01/00/22_003/0000048 via the Operational Programme Just
   Transition.
CR Berner-Hansen V, 2021, HERNIA, V25, P1481, DOI 10.1007/s10029-021-02485-7
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NR 13
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD SEP
PY 2024
VL 60
IS 9
AR 1548
DI 10.3390/medicina60091548
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H5P9I
UT WOS:001323970700001
PM 39336589
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kim, JH
   Kim, JW
   Ha, M
   Lee, KM
AF Kim, Jong-Ho
   Kim, Jin-Woo
   Ha, Minju
   Lee, Kyoung Min
TI Retrospective analysis of healing outcomes and associated factors in
   patients with pressure ulcers
SO MEDICINE
LA English
DT Article
DE logistic regression; negative pressure wound therapy; pressure-ulcer;
   prognostic factors; retrospective study; wound healing
ID SPINAL-CORD-INJURY; RISK-FACTORS; WOUND THERAPY; PREDICTORS
AB Pressure ulcers (PUs) are serious complications among immobilized or chronically ill patients, often resulting in prolonged hospitalization, morbidity, and increased healthcare costs. Despite therapeutic advances, predictors of long-term healing remain unclear. This study aimed to identify factors associated with 1-year healing outcomes in patients with advanced PUs. This retrospective cohort study included adult patients diagnosed with PUs of grade 2 or higher between January 2020 and January 2025. Clinical, laboratory, and wound-related variables were obtained from electronic records, including demographic data, comorbidities, nutritional indicators, ulcer features (stage, location, size, infection, and bone exposure), and treatment modalities such as negative pressure wound therapy (NPWT) and surgical debridement. The primary outcome measure was complete wound healing within 12 months. Univariate and multivariate logistic regression analyses identified independent predictors of healing. A total of 240 patients (mean age, 61.5 +/- 10.6 years; 69.6% male) were included in the final analysis. Complete healing at 12 months was achieved in 48.8% of the patients. In the multivariate logistic regression model, NPWT, hospital-based treatment, lower initial ulcer stage, and absence of paralysis were independently associated with complete healing, with all predictors reaching statistical significance (all P < .01). NPWT, hospital-based management, lower initial ulcer stage, and absence of paralysis were strongly associated with improved 1-year healing outcomes in patients with advanced PUs. These findings highlight the importance of early, structured wound care and suggest that both the treatment setting and patient mobility status play critical roles in long-term recovery.
C1 [Kim, Jong-Ho; Kim, Jin-Woo; Ha, Minju] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Plast & Reconstruct Surg, Seongnam, South Korea.
   [Lee, Kyoung Min] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Orthoped Surg, 82 Gumi Ro 173beon Gil, Seongnam 463707, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Lee, KM (通讯作者)，Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Orthoped Surg, 82 Gumi Ro 173beon Gil, Seongnam 463707, South Korea.
EM jinwooo_kim@naver.com; jinwooo_kim@naver.com; mjha0303@naver.com;
   oasis100@empal.com
FU Institute for Information and Communications Technology Promotion
   [2022-0-00682]
FX This work was supported by an Institute of Information and
   Communications Technology Planning and Evaluation (IITP) grant funded by
   the Korean government(MSIT; No. 2022-0-00682, Development of XR twin
   technology for the management of chronic skin diseases in the elderly).
CR Alabdulhadi Abdulhadi A, 2024, Cureus, V16, pe73199, DOI [10.7759/cureus.73199, 10.7759/cureus.73199]
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NR 31
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 24
PY 2026
VL 105
IS 17
AR e48386
DI 10.1097/MD.0000000000048386
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB7RQ
UT WOS:001750280400033
PM 42071811
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Woldesenbet, A
   Mcginley, C
   Fossett, D
AF Woldesenbet, Amanuel
   Mcginley, Christopher
   Fossett, Damirez
TI Negative Pressure Wound Therapy: An Analysis of Its Effectiveness on the
   Reduction of Postoperative Infection in Posterior Spine Surgery
SO WORLD NEUROSURGERY
LA English
DT Article
DE Comorbidity; Negative pressure; Posterior approach; Postoperative
   infections; Prevena; Spinal surgical site infections; Thoracolumbar
ID SURGICAL SITE INFECTION; RISK-FACTORS; PREVENTION; FUSION; INCISIONS;
   RATES
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been used for postsurgical wound management across various disciplines, including spinal surgery. However, its efficacy in reducing wound infection rates after posterior thoracolumbar spine surgery remains uncertain. METHODS: A retrospective review was conducted at a single institution, examining 266 patients who underwent posterior thoracic, lumbar, or thoracolumbar spine surgery performed by 1 neurosurgeon. Data included NPWT usage, type of surgery, infection rates, prior spinal surgeries, demographics, comorbidities, smoking status, and immune profiles. Statistical analysis was performed to evaluate correlations. RESULTS: Of the 266 patients, 122 (46%) were males, 144 (54%) were females, and 213 (80%) were Black. Patients had a mean age of 56.4 years and an average body mass index of 29.6 kg/m(2). NPWT was applied to 153 patients (57.5%). Postoperative wound infections occurred in 35 patients (13%), with 19 (54%) in the NPWT group. Overall, NPWT use was not associated with a statistically significant reduction in infection rates (P = 0.69). However, analysis of patients with multiple comorbidities showed a significant decrease in infections with NPWT (P< 0.01). A total of 198 patients (74.4%) had at least 1 comorbidity, and 10.1% (n = 20) had 2 or more major comorbidities. CONCLUSIONS: NPWT significantly reduced infection rates in patients with multiple comorbidities, suggesting its potential benefit in managing wound infections in this subgroup. This finding is particularly relevant for an urban, minority patient population, highlighting the importance of tailored wound care strategies.
C1 [Woldesenbet, Amanuel; Mcginley, Christopher] HOWARD UNIV, Coll Med, Dept Neurosurg, WASHINGTON, DC 20059 USA.
   [Fossett, Damirez] Howard Univ Hosp, Dept Surg, Div Neurosurg, Washington, DC USA.
C3 Howard University; Howard University
RP Woldesenbet, A (通讯作者)，HOWARD UNIV, Coll Med, Dept Neurosurg, WASHINGTON, DC 20059 USA.
EM W.amanuel94@gmail.com
OI McGinley, Christopher/0009-0003-2533-1068
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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   White AJ, 2022, ASIAN SPINE J, V16, P451
NR 32
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD FEB
PY 2025
VL 194
AR 123591
DI 10.1016/j.wneu.2024.123591
EA JAN 2025
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA T3U0Q
UT WOS:001404287300001
PM 39725287
OA hybrid
DA 2026-07-24
ER

PT J
AU Babu, B
   Gaba, S
   John, JR
   Subair, M
AF Babu, Basil
   Gaba, Sunil
   John, Jerry R.
   Subair, Mohsina
TI Comparison of Efficacy of Vacuum Dressing Versus Conventional Dressing
   Over Autologous Split Skin Grafts in Burn Wounds: A Single-Center
   Prospective Cohort Study
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE burns; vacuum dressing; negative-pressure wound therapy; skin grafts
ID PRESSURE; THERAPY; TRIAL
AB This study was carried out to compare the efficacy of vacuum dressing and conventional dressing over split skin grafts in burn patients. It was a single-center prospective cohort study on patients, with less than 40% TBSA burn, undergoing skin grafting at 2 different sites simultaneously over the burn wounds. One site underwent conventional dressing following grafting, and the other underwent vacuum dressing. The primary objective was to compare the percentages of skin graft uptake on Day 5 and Day 14. The secondary objectives were to compare the duration of dressings, time for complete epithelization, need for regrafting, and wound swab culture positivity rates. Three independent examiners assessed the efficacy of dressings in terms of epithelization percentage, need for continued dressing, graft loss, wound swab culture positivity rate, and qualitative assessment of grafts. A total of 16 patients were included in the study. The graft loss, number of days of dressings, and complete epithelization time were statistically lower in the negative-pressure wound therapy (NPWT) group compared with the conventional group (P values .007, .006, and 0009, respectively). The percentage of epithelization was also found to be higher in the NPWT group (P = .006). The incidence of positive cultures and clinically significant graft loss was found to be lower in the NPWT group. However, this was not found to be statistically significant. NPWT dressings can be used in burn wounds following skin grafting and have been found to reduce the time for epithelization compared to conventional dressing.
C1 [Babu, Basil] Post Grad Inst Med Educ & Res PGIMER, Dept Gen Surg, Chandigarh 160012, India.
   [Gaba, Sunil; John, Jerry R.; Subair, Mohsina] Post Grad Inst Med Educ & Res PGIMER, Dept Plast & Reconstruct Surg, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Babu, B (通讯作者)，Post Grad Inst Med Educ & Res PGIMER, Dept Gen Surg, Chandigarh 160012, India.
EM drbasilms@gmail.com
RI ; subair, mohsina/JWO-9377-2024; Babu, Basil/KFR-4984-2024
OI Gaba, Sunil/0000-0001-8743-5987; subair, mohsina/0000-0003-0164-0053;
   Babu, Basil/0009-0007-0087-5105
CR Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Gore MA., 2013, INTECHOPEN
   Kagan RJ, 2013, J BURN CARE RES, V34, pE60, DOI 10.1097/BCR.0b013e31827039a6
   Kumar NA, 2016, INT J SCI STUDY, V4, P220, DOI 10.17354/ijss/2016/410
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   Lin DZ, 2021, INT WOUND J, V18, P112, DOI 10.1111/iwj.13500
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NR 14
TC 3
Z9 3
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR 4
PY 2024
VL 45
IS 2
BP 468
EP 477
DI 10.1093/jbcr/irad181
EA NOV 2023
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA KD8C6
UT WOS:001114023100001
PM 37950743
DA 2026-07-24
ER

PT J
AU Svensson-Björk, R
   Hasselmann, J
   Asciutto, G
   Zarrouk, M
   Björk, J
   Bilos, L
   Pirouzram, A
   Acosta, S
AF Svensson-Bjork, Robert
   Hasselmann, Julien
   Asciutto, Giuseppe
   Zarrouk, Moncef
   Bjork, Jonas
   Bilos, Linda
   Pirouzram, Artai
   Acosta, Stefan
TI Negative Pressure Wound Therapy for the Prevention of Surgical Site
   Infections Using Fascia Closure After EVAR-A Randomized Trial
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID SUTURE TECHNIQUE; CLINICAL-TRIALS; EDITORS CHOICE; METAANALYSIS;
   RECONSTRUCTION; COMPLICATIONS; DEVICES; ACCESS
AB Background Surgical site infections (SSI) in the groin after vascular surgery are common. The aim of the study was to evaluate the effect of negative pressure wound therapy (NPWT) on SSI incidence when applied on closed inguinal incisions after endovascular aneurysm repair (EVAR). Methods A multicenter randomized controlled trial (RCT). Between November 2013 and December 2020, 377 incisions (336 bilateral and 41 unilateral) from elective EVAR procedures with the primary intent of fascia closure were randomized and included, receiving either NPWT or a standard dressing. In bilateral incisions, each incision randomly received the opposite dressing of the other side, thereby becoming each other's control. The primary endpoint was SSI incidence at 90 days postoperatively, analyzed on an intention-to-treat basis. Uni and bilaterally operated incisions were analyzed separately, and their respective p-values combined using Fisher's method for combining P-values. Study protocol (NCT01913132). Results The SSI incidence at 90 days postoperatively in bilateral incisions was 1.8% (n = 3/168) in the NPWT and 4.8% (n = 8/168) in the standard dressing group, and in unilateral incisions 13.3% (n = 2/15) and 11.5% (n = 3/26), respectively (combined p = 0.49). In all SSIs, bacteria were isolated from incisional wound cultures. No additional SSIs were diagnosed between 90 days and 1 year follow-up. Conclusions No evidence of difference in SSI incidence was seen in these low-risk inguinal incisions when comparing NPWT with standard dressings after EVAR with the primary intent of fascia closure.
C1 [Svensson-Bjork, Robert; Hasselmann, Julien; Asciutto, Giuseppe; Zarrouk, Moncef; Acosta, Stefan] Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
   [Hasselmann, Julien; Zarrouk, Moncef; Acosta, Stefan] Skane Univ Hosp, Vasc Ctr, Malmo, Sweden.
   [Asciutto, Giuseppe] Uppsala Univ Hosp, Dept Vasc Surg, Uppsala, Sweden.
   [Bjork, Jonas] Lund Univ, Div Occupat & Environm Med, Lund, Sweden.
   [Bjork, Jonas] Lund Univ, Forum South, Clin Studies Sweden, Lund, Sweden.
   [Bilos, Linda; Pirouzram, Artai] Linkoping Univ Hosp, Dept Cardiothorac & Vasc Surg, Vasc Surg Unit, Linkoping, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Uppsala
   University; Uppsala University Hospital; Lund University; Lund
   University; Linkoping University
RP Svensson-Björk, R (通讯作者)，Lund Univ, Dept Clin Sci, Vasc Dis Res Unit, Ruth Lundskogs Gata 10, S-20502 Malmo, Sweden.
EM Robert.Svensson_Bjork@med.lu
RI Acosta, Stefan/JAX-3225-2023; Björk, Jonas/AFS-4819-2022
OI Acosta, Stefan/0000-0002-3225-0798; Björk, Jonas/0000-0003-1883-2000
FU Lund University; Swedish medical research council [2019-00435]; Hulda
   Almroth Foundation; Skane University hospital, Region Skane; Swedish
   government; Swedish Research Council [2019-00435] Funding Source:
   Swedish Research Council
FX Open access funding provided by Lund University. Research funds were
   received from the Swedish medical research council (2019-00435), the
   Hulda Almroth Foundation, Skane University hospital, Region Skane, the
   Swedish government under the ALF agreement and Smith & Nephew (2013)
   which also provided 100 PICOTM dressings. The funding sources were not
   involved in study design, analysis, interpretation, writing or
   submission of the manuscript.
CR Antoniou GA, 2021, EUR J VASC ENDOVASC, V61, P383, DOI 10.1016/j.ejvs.2020.11.008
   Antoniou GA, 2019, J VASC SURG, V70, P1700, DOI 10.1016/j.jvs.2019.01.083
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   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
   Trinidad B, 2019, INT J ANGIOL, V28, P124, DOI 10.1055/s-0039-1683898
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   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   WILSON APR, 1986, LANCET, V1, P311
NR 23
TC 13
Z9 15
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2022
VL 46
IS 12
BP 3111
EP 3120
DI 10.1007/s00268-022-06740-5
EA OCT 2022
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Y1GG
UT WOS:000873936200002
PM 36241857
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Gabriel, A
   Camardo, M
   O'Rorke, E
   Gold, R
   Kim, PJ
AF Gabriel, Allen
   Camardo, Mark
   O'Rorke, Erin
   Gold, Rebecca
   Kim, Paul J.
TI Effects of Negative-Pressure Wound Therapy With Instillation versus
   Standard of Care in Multiple Wound Types: Systematic Literature Review
   and Meta-Analysis
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID ANTISEPTIC SOLUTION; SALINE
AB Background: Large randomized controlled trials that evaluate the effects of negative-pressure wound therapy with instillation of a topical solution and dwell time (NPWTi-d) are lacking. There is a need to synthesize existing data across multiple studies to provide a more precise estimate of the clinical effects of NPWTi-d.
   Methods: A systematic literature review and a meta-analysis of comparative studies were performed to determine the effects of NPWTi-d versus control therapy in the adjunctive management of complex wounds. Weighted standardized mean difference or odds ratios and 95% confidence intervals were calculated to pool study and control group results in each publication for analysis.
   Results: Thirteen studies comprising 720 patients were included in the analysis. Significantly fewer surgical debridements were performed in NPWTi-d patients versus control patients (P = 0.01). Wounds in the NPWTi-d group were ready for closure faster than control wounds (P = 0.03). The odds of reducing bacterial count from baseline in the NPWTi-d group was 4.4 times greater than control group wounds (P = 0.003), and percent reduction of bacterial count in NPWTi-d wounds was evident in all studies that captured that endpoint. There was a significantly shorter length of therapy in NPWTi-d patients versus control patients (P = 0.03). Wounds in NPWTi-d group were 2.39 times more likely to close than control group wounds (P = 0.01). Length of hospital stay was not significantly reduced for NPWTi-d patients compared with that for control patients (P = 0.06).
   Conclusion: Results of this meta-analysis show a positive effect with use of NPWTi-d in various wound types.
C1 Loma Linda Univ, Dept Plast Surg, Loma Linda, CA 92350 USA.
   3M, San Antonio, TX USA.
   Washington State Univ, Washington, DC USA.
   Washington State Univ, Elson S Floyd Coll Med, Washington, DC USA.
   Univ Texas Southwestern Med Ctr Dallas, Dallas, TX USA.
C3 Loma Linda University; 3M; Washington State University; Washington State
   University; University of Texas System; University of Texas Southwestern
   Medical Center
RP Gabriel, A (通讯作者)，505 NE 87th Avene,Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI ; Gabriel, Allen/AFK-3548-2022
OI , Paul/0000-0002-6186-6890; 
CR Chowdhry SA, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002087
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   DeFazio MV, 2017, WOUNDS, V29, P289
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   Fernández L, 2019, WOUNDS, V31, pE1
   Gabriel A., 2014, EPLASTY, V14, P41
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
   Garcia-Ruano A, 2016, J SURG RES, V206, P292, DOI 10.1016/j.jss.2016.08.030
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   Lessing C, 2011, WOUNDS, V23, P309
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   Söylemez MS, 2016, THER CLIN RISK MANAG, V12, P161, DOI 10.2147/TCRM.S97930
   SVEDMAN P, 1979, IRCS (International Research Communications System) Medical Science Library Compendium, V7, P221
   Timmers MS, 2009, WOUND REPAIR REGEN, V17, P278, DOI 10.1111/j.1524-475X.2009.00458.x
   West JM, 2018, ADV WOUND CARE, V7, P333, DOI 10.1089/wound.2018.0793
   Wolvos T, 2015, J WOUND CARE, V24, P15, DOI 10.12968/jowc.2015.24.Sup4b.15
   Yang CK, 2015, J VASC SURG, V61, P995, DOI 10.1016/j.jvs.2014.11.076
   Yang C, 2017, WOUNDS, V29, P240
NR 28
TC 35
Z9 41
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 68S
EP 76S
DI 10.1097/PRS.0000000000007614
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500011
PM 33347065
DA 2026-07-24
ER

PT J
AU Tao, R
   Xue, CY
   Yang, CH
   Simfukwe, K
   Hu, XW
   Wu, X
   Bi, HD
AF Tao, Ran
   Xue, Chunyu
   Yang, Chunhui
   Simfukwe, Keith
   Hu, Xiaowu
   Wu, Xi
   Bi, Hongda
TI Reconstruction of chronic scalp erosion after deep brain stimulation
   surgery
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Local scalp flap; Negative pressure wound therapy; Deep brain
   stimulation; Parkinson's disease
ID SHAPED SKIN INCISION; MANAGEMENT; COMPLICATIONS
AB Objective: To investigate the reconstructive effectiveness for chronic scalp erosion after deep brain stimulation (DBS).
   Background: Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease. However, this surgery is not exempt from hard-ware related complications, especially scalp erosions on scalp. Scalp erosions usually accompanied with chronic infection and wound contamination. If not arrested, infections may spread through the entire equipment which would endanger the patient's life. Along with review of previous literatures, we summarized our experience in the management of scalp erosion and implemented a systemic treatment plan for reconstruction.
   Methods: We retrospectively analyzed the clinical data of patients with chronic scalp erosion after DBS in the past 40 months. The treatment plan was composed of three sequential major steps, including wound care and conservative methods, debridement and local flap, and revaluation of the wound. In each of the cases, wound debridement and local scalp flap repair were conducted, and assisted by negative pressure wound therapy (NPWT) device and double cannula irrigation.
   Results: The local scalp flap survived in all 6 patients. The chronic scalp erosions all healed without refractory. The DBS devices still functioned properly after the treatments in all patients. The average follow-up period was 13.33 months (range: 4 to 23 months), and no infection recurrence or re-erosion of the scalp flap was reported.
   Conclusion: A combination of wound debridement, local scalp flap repair, the use of NPWT device and double cannula irrigation provides effective treatment method for chronic erosion post DBS surgery. (C) 2020 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
C1 [Tao, Ran; Xue, Chunyu; Bi, Hongda] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
   [Yang, Chunhui; Hu, Xiaowu; Wu, Xi] Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
   [Simfukwe, Keith] Mordovia Republican Clin Hosp, Dept Neurosurg, Pobedi St, Saransk, Russia.
C3 Naval Medical University; Naval Medical University
RP Bi, HD (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.; Wu, X (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Neurosurg, 168 Changhai Rd,Yangpu Dist, Shanghai, Peoples R China.
EM wuxi_smmu@sina.com; bihongda0411@163.com
FU "Digital Equipment of Diagnosis and Treatment" special program of
   National Key Research and Development Plan [2016YFC0105900]
FX This work was supported by "Digital Equipment of Diagnosis and
   Treatment" special program of National Key Research and Development Plan
   (2016YFC0105900) .
CR Bhatia S, 2010, STEREOT FUNCT NEUROS, V88, P147, DOI 10.1159/000303528
   Constantoyannis C, 2005, CAN J NEUROL SCI, V32, P194, DOI 10.1017/S0317167100003966
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   Lanotte M, 2009, NEUROSURG REV, V32, P111, DOI 10.1007/s10143-008-0158-0
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   Zhou RS, 2018, WORLD NEUROSURG, V117, P280, DOI 10.1016/j.wneu.2018.05.224
NR 12
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2021
VL 74
IS 8
BP 1807
EP 1813
DI 10.1016/j.bjps.2020.11.045
EA JUL 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TP3GD
UT WOS:000677481000013
PM 33358678
DA 2026-07-24
ER

PT J
AU Saunders, C
   Nherera, LM
   Horner, A
   Trueman, P
AF Saunders, C.
   Nherera, L. M.
   Horner, A.
   Trueman, P.
TI Single-use negative-pressure wound therapy versus conventional dressings
   for closed surgical incisions: systematic literature review and
   meta-analysis
SO BJS OPEN
LA English
DT Review
ID INFECTION; TRIAL
AB Background: Surgical-site complications (SSCs) remain a significant cause of morbidity and mortality, particularly in high-risk patients. The aim of this study was to determine whether prophylactic use of a specific single-use negative-pressure wound therapy (sNPWT) device reduced the incidence of SSCs after closed surgical incisions compared with conventional dressings.
   Methods: A systematic literature review was performed using MEDLINE, Embase and the Cochrane Library to identify articles published from January 2011 to August 2018. RCTs and observational studies comparing PICO (TM) sNPWT with conventional dressings, with at least 10 patients in each treatment arm, were included. Meta-analyses were performed to determine odds ratios (ORs) or mean differences (MDs), as appropriate. PRISMA guidelines were followed. The primary outcome was surgical-site infection (SSI). Secondary outcomes were other SSCs and hospital efficiencies. Risk of bias was assessed.
   Results: Of 6197 citations screened, 29 studies enrolling 5614 patients were included in the review; all studies included patients with risk factors for SSCs. sNPWT reduced the number of SSIs (OR 0.37, 95 per cent c.i. 0.28 to 0.50; number needed to treat (NNT) 20). sNPWT reduced the odds of wound dehiscence (OR 0.70, 0.53 to 0.92; NNT 26), seroma (OR 0.23, 0.11 to 0.45; NNT 13) and necrosis (OR 0.11, 0.03 to 0.39; NNT 12). Mean length of hospital stay was shorter in patients who underwent sNPWT (MD -1.75, 95 per cent c.i. -2.69 to -0.81).
   Conclusion: Use of the sNPWT device in patients with risk factors reduced the incidence of SSCs and the mean length of hospital stay.
C1 [Saunders, C.; Horner, A.] Smith Nephew, Global Clin Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
   [Nherera, L. M.; Trueman, P.] Smith Nephew, Hlth Econ & Market Access, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew; Smith & Nephew
RP Saunders, C (通讯作者)，Smith Nephew, Global Clin Affairs, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM Christopher.Saunders@smith-nephew.com
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
   Ambler G, 2018, FLUID HANDLING NEGAT
   [Anonymous], SYSTEMATIC REV CRDS
   Chaboyer W, 2014, HEALTHCARE, V2, P417, DOI 10.3390/healthcare2040417
   Critical Appraisal Skills Programme, CASP CHECKL 12 QUEST
   Dingemans SA, 2018, INT ORTHOP, V42, P747, DOI 10.1007/s00264-018-3781-6
   Fleming CA, 2018, J HOSP INFECT, V99, P75, DOI 10.1016/j.jhin.2017.10.022
   Galiano RD, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000001560
   Gillespie BM, 2015, SURG INNOV, V22, P488, DOI 10.1177/1553350615573583
   Gillespie BM, 2013, WOUND PRACT RES, V21, P74
   Gupta R, 2017, AM SURGEON, V83, P1166
   Hackney L, 2017, 12 SCIENT ANN M EUR
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   Tuuli MG, 2017, AM J OBSTET GYNECOL, V216, pS245, DOI 10.1016/j.ajog.2016.11.670
   Uchino M, 2016, DIGEST SURG, V33, P449, DOI 10.1159/000446550
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   World Union of Healing Societies, CLOS SURG INC MAN UN
   Zotes V, 2015, INTERACT CARDIOV TH, V21, P187
NR 36
TC 24
Z9 26
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD JAN
PY 2021
VL 5
IS 1
AR zraa003
DI 10.1093/bjsopen/zraa003
EA JAN 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SA6VX
UT WOS:000649440900001
PM 33609382
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Meyer, J
   Roos, E
   Davies, RJ
   Buchs, NC
   Ris, F
   Toso, C
AF Meyer, Jeremy
   Roos, Elin
   Davies, Richard Justin
   Buchs, Nicolas Christian
   Ris, Frederic
   Toso, Christian
TI Does Prophylactic Negative-Pressure Wound Therapy Prevent Surgical Site
   Infection After Laparotomy? A Systematic Review and Meta-analysis of
   Randomized Controlled trials
SO WORLD JOURNAL OF SURGERY
LA English
DT Review
ID SURGERY; COMPLICATIONS; INCISIONS; IMPACT; COSTS
AB BackgroundProphylactic negative-pressure wound therapy (pNPWT) may prevent surgical site infection (SSI) after laparotomy, but existing meta-analyses pooling only high-quality evidence have failed to confirm this effect. Recently, several randomized controlled trials (RCTs) have been published. We performed an updated systematic review and meta-analysis to determine if pNPWT reduces the incidence of SSI after laparotomy.MethodsMEDLINE, Embase, CENTRAL and Web of Science were searched on the 25.08.2021 for RCTs reporting on the incidence of SSI in patients who underwent laparotomy with and without pNPWT. The systematic review was compliant with the AMSTAR2 recommendation and registered into PROSPERO. Risk ratios (RR) for SSI in patients with pNPWT, and risk difference (RD) between control and pNPWT patients, were obtained using random effects models. Heterogeneity was quantified using the I-2 value, and investigated using subgroup analyses, funnel plots and bubble plots. Risk of bias of included RCTs was assessed using the RoB2 tool.ResultsEleven RCTs were included, representing 973 patients who received pNPWT and 970 patients who received standard wound dressing. Pooled RR and RD between patients with and without pNPWT were of, respectively, 0.665 (95% CI 0.49-0.91, I-2: 38.7%, p = 0.0098) and -0.07 (95% CI -0.12 to -0.03, I-2: 53.6%, p = 0.0018), therefore demonstrating that pNPWT decreases the incidence of SSI after laparotomy. Investigation of source of heterogeneity identified a potential small-study effect.ConclusionThe protective effect of pNPWT against SSI after laparotomy is confirmed by high-quality pooled evidence.
C1 [Meyer, Jeremy; Buchs, Nicolas Christian; Ris, Frederic; Toso, Christian] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Meyer, Jeremy; Buchs, Nicolas Christian; Ris, Frederic; Toso, Christian] Univ Geneva, Med Sch, Unit Surg Res, Geneva, Switzerland.
   [Meyer, Jeremy; Davies, Richard Justin] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge Colorectal Unit, Cambridge, England.
   [Roos, Elin] Karolinska Inst, Dept Global Publ Hlth, Solna, Sweden.
C3 University of Geneva; University of Geneva; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; Karolinska Institutet
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.; Meyer, J (通讯作者)，Univ Geneva, Med Sch, Unit Surg Res, Geneva, Switzerland.; Meyer, J (通讯作者)，Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge Colorectal Unit, Cambridge, England.
EM jeremy.meyer@hcuge.ch
RI Meyer, Jeremy/AAP-3367-2020; Ris, Frederic/H-7030-2019; Toso,
   Christian/E-7785-2018
OI Meyer, Jeremy/0000-0003-3381-9146; Ris, Frederic/0000-0001-7421-6101;
   Toso, Christian/0000-0003-1652-4522
FU University of Geneva
FX Open access funding provided by University of Geneva.
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NR 35
TC 18
Z9 19
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUN
PY 2023
VL 47
IS 6
BP 1464
EP 1474
DI 10.1007/s00268-023-06908-7
EA JAN 2023
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AK5X9
UT WOS:000918726600001
PM 36658232
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Frear, CC
   Cuttle, L
   McPhail, SM
   Chatfield, MD
   Kimble, RM
   Griffin, BR
AF Frear, C. C.
   Cuttle, L.
   McPhail, S. M.
   Chatfield, M. D.
   Kimble, R. M.
   Griffin, B. R.
TI Randomized clinical trial of negative pressure wound therapy as an
   adjunctive treatment for small-area thermal burns in children
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 43rd Annual Scientific Meeting of the
   Australian-and-New-Zealand-Burn-Association
CY OCT, 2019
CL Hobart, AUSTRALIA
SP Australian & New Zealand Burn Assoc
ID PARTIAL-THICKNESS BURNS; SUBATMOSPHERIC PRESSURE; PEDIATRIC BURNS;
   ASSESSMENT SCALE; HEALING TIME; PROGRESSION; EPIDEMIOLOGY; MANAGEMENT;
   INFANTS; PROFILE
AB Background The efficacy of negative pressure wound therapy (NPWT) in the acute management of burns remains unclear. The purpose of this trial was to compare standard Acticoat (TM) and Mepitel (TM) dressings with combined Acticoat (TM), Mepitel (TM) and continuous NPWT to determine the effect of adjunctive NPWT on re-epithelialization in paediatric burns. Methods This two-arm, single-centre RCT recruited children with acute thermal burns covering less than 5 per cent of their total body surface area. The primary outcome was time to re-epithelialization. Blinded assessments were performed using photographs captured every 3-5 days until discharge. Secondary measures included pain, itch, grafting, perfusion and scar management referrals. Results Some 114 patients were randomized. Median time to re-epithelialization was 8 (i.q.r. 7-11) days in the NPWT group and 10 (8-14) days in the control group. In a multivariable model, NPWT decreased the expected time to wound closure by 22 (95 per cent c.i. 7 to 34) per cent (P = 0 center dot 005). The risk of referral to scar management was reduced by 60 (18 to 81) per cent (P = 0 center dot 013). Four participants in the control group and one in the NPWT group underwent grafting. There were no statistically significant differences between groups in pain, itch or laser Doppler measures of perfusion. Adverse events were rare and minor, although NPWT carried a moderate treatment burden, with ten patients discontinuing early. Conclusion Adjunctive NPWT hastened re-epithelialization in small-area burn injuries in children, but had a greater treatment burden than standard dressings alone. Registration number: ACTRN12618000256279 ( ).
C1 [Frear, C. C.; Cuttle, L.; Kimble, R. M.; Griffin, B. R.] Ctr Childrens Burns & Trauma Res, South Brisbane, Qld, Australia.
   [Kimble, R. M.] Queensland Childrens Hosp, South Brisbane, Qld, Australia.
   [Frear, C. C.; Chatfield, M. D.; Kimble, R. M.] Univ Queensland, Fac Med, Herston, Qld, Australia.
   [Cuttle, L.] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.
   [McPhail, S. M.] Queensland Univ Technol, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia.
   [McPhail, S. M.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat, Brisbane, Qld, Australia.
   [Griffin, B. R.] Queensland Univ Technol, Fac Hlth, Sch Nursing, Brisbane, Qld, Australia.
   [McPhail, S. M.] Metro South Hlth, Clin Informat Directorate, Brisbane, Qld, Australia.
C3 Childrens Health Queensland Hospital & Health Service; Queensland
   Childrens Hospital; University of Queensland; Queensland University of
   Technology (QUT); Queensland University of Technology (QUT); Queensland
   University of Technology (QUT); Queensland University of Technology
   (QUT)
RP Frear, CC (通讯作者)，Univ Queensland, Childrens Hlth Res Ctr, Ctr Childrens Burns & Trauma Res, Level 7,62 Graham St, South Brisbane, Qld 4101, Australia.
EM cody.frear@uqconnect.edu.au
RI ; Cuttle, Leila/C-5223-2008; Chatfield, Mark/N-2278-2013; Griffin,
   Bronwyn/AEB-6299-2022; Kimble, Roy/B-4160-2011; McPhail,
   Steven/JMR-2141-2023
OI Frear, Cody/0000-0002-6011-2472; Cuttle, Leila/0000-0002-2282-4815;
   Chatfield, Mark/0000-0002-0004-6274; Griffin,
   Bronwyn/0000-0002-6182-9125; McPhail, Steven/0000-0002-1463-662X
FU Australian Government Research Training Scholarship; Smith Nephew;
   Australian Government, National Health and Medical Research Council
   [APP1130862]
FX The authors acknowledge the children, families and clinicians who
   participated in the SONATA in C trial. They thank A. Bairagi, C.
   McMillan, B. Meikle and R. Walker for their contribution to the blinded
   reviews, and A. Bernard and F. Zahir for statistical input. Funding for
   the study was provided by an Australian Government Research Training
   Scholarship and a research grant from Smith & Nephew to the Queensland
   University of Technology. L.C. acknowledges Fellowship funding from the
   Australian Government, National Health and Medical Research Council
   (APP1130862). Smith & Nephew's involvement in the research was limited
   to its financial support. The funders had no role in the study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 47
TC 30
Z9 35
U1 3
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD DEC
PY 2020
VL 107
IS 13
BP 1741
EP 1750
DI 10.1002/bjs.11993
EA SEP 2020
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA OP9VK
UT WOS:000568883400001
PM 32926410
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Takami, T
   Itatani, Y
   Yoshida, Y
   Hoshino, N
   Ohno, R
   Okamura, R
   Hida, K
   Obama, K
AF Takami, Takuya
   Itatani, Yoshiro
   Yoshida, Yu
   Hoshino, Nobuaki
   Ohno, Ryo
   Okamura, Ryosuke
   Hida, Koya
   Obama, Kazutaka
TI Protocol for a study to evaluate the safety and efficacy of prophylactic
   negative pressure wound therapy after abdominal perineal resection
   (VACPAC study)
SO PLOS ONE
LA English
DT Article
ID ABDOMINOPERINEAL RESECTION; RECTAL-CANCER; INCISION MANAGEMENT;
   EXCISION; CLOSURE; RECONSTRUCTION; RADIOTHERAPY; INFECTIONS; SYSTEM
AB Introduction Abdominal perineal resection (APR) is a surgical procedure for rectal cancer that frequently results in perineal wound surgical site infections (SSI), particularly in high-risk patients undergoing preoperative treatment. SSI after APR is associated with prolonged hospital stay, increased medical costs, and delayed initiation of adjuvant chemotherapy, potentially leading to poor prognosis. Although omentoplasty and myocutaneous flap reconstruction have been used to prevent SSI, they are not always feasible. Prophylactic negative pressure wound therapy (pNPWT) has been shown to reduce SSI in high-risk wounds; however, its efficacy in APR remains unclear. This study aims to evaluate the safety and efficacy of pNPWT in preventing perineal wound SSI after APR.Methods and materials This is a multi-institutional, single-arm trial investigating pNPWT after APR. The study includes patients undergoing APR for malignant rectal tumors who meet the high-risk criteria for SSI. The intervention involves applying the 3M (TM) Prevena (TM) Plus Customizable system immediately after perineal skin closure, maintaining pNPWT for up to 7 days. The primary endpoint is the incidence of perineal wound SSI within 30 days. Secondary endpoints include postoperative complications (Clavien-Dindo Grade III or higher), hospital stay, and completion proportion of pNPWT.Discussion This study seeks to provide clinical evidence of the efficacy of pNPWT in reducing perineal wound SSI after APR. Given its ease of application and minimal invasiveness, pNPWT may serve as an effective approach for SSI prevention. These findings may contribute to the establishment of a standardized preventive approach for perineal wound management after APR.
C1 [Takami, Takuya; Itatani, Yoshiro; Yoshida, Yu; Hoshino, Nobuaki; Ohno, Ryo; Okamura, Ryosuke; Hida, Koya; Obama, Kazutaka] Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan.
C3 Kyoto University
RP Itatani, Y (通讯作者)，Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan.
EM itatani@kuhp.kyoto-u.ac.jp
RI ; Hida, Koya/AFU-1462-2022; Itatani, Yoshiro/GXA-0613-2022; OBAMA,
   KAZUTAKA/AAW-8263-2021
OI Okamura, Ryosuke/0000-0001-7352-8621; Itatani,
   Yoshiro/0000-0001-7356-7065; 
FU Japan society of laparoscopic colorectal surgery
FX Japan society of laparoscopic colorectal surgery
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Benedict KC, 2023, J PLAST RECONSTR AES, V84, P514, DOI 10.1016/j.bjps.2023.06.020
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 29
PY 2025
VL 20
IS 8
AR e0331361
DI 10.1371/journal.pone.0331361
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8DB6L
UT WOS:001585788200027
PM 40880392
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shao, PL
   Liao, JD
   Wu, SC
   Chen, YH
   Wong, TW
AF Shao, Pei-Lin
   Liao, Jiunn-Der
   Wu, Shun-Cheng
   Chen, Yu-Hsing
   Wong, Tak-Wah
TI Microplasma Treatment versus Negative Pressure Therapy for Promoting
   Wound Healing in Diabetic Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE diabetic wound; nonthermal microplasma treatment; negative pressure
   wound therapy; re-epithelialization; transforming growth factor beta
   signaling
ID NITRIC-OXIDE; PLASMA; EXPRESSION; SKIN; EPITHELIALIZATION;
   MYOFIBROBLASTS; STERILIZATION; ANGIOGENESIS; IMPAIRMENTS; MODELS
AB The delayed healing response of diabetic wounds is a major challenge for treatment. Negative pressure wound therapy (NPWT) has been widely used to treat chronic wounds. However, it usually requires a long treatment time and results in directional growth of wound healing skin tissue. We investigated whether nonthermal microplasma (MP) treatment can promote the healing of skin wounds in diabetic mice. Splint excision wounds were created on diabetic mice, and various wound healing parameters were compared among MP treatment, NPWT, and control groups. Quantitative analysis of the re-epithelialization percentage by detecting Ki67 and DSG1 expression in the extending epidermal tongue (EET) of the wound area and the epidermal proliferation index (EPI) was subsequently performed. Both treatments promoted wound healing by enhancing wound closure kinetics and wound bed blood flow; this was confirmed through histological analysis and optical coherence tomography. Both treatments also increased Ki67 and DSG1 expression in the EET of the wound area and the EPI to enhance re-epithelialization. Increased Smad2/3/4 mRNA expression was observed in the epidermis layer of wounds, particularly after MP treatment. The results suggest that the Smad-dependent transforming growth factor beta signaling contributes to the enhancement of re-epithelialization after MP treatment with an appropriate exposure time. Overall, a short-term MP treatment (applied for 30 s twice a day) demonstrated comparable or better efficacy to conventional NPWT (applied for 4 h once a day) in promoting wound healing in diabetic mice. Thus, MP treatment exhibits promise for treating diabetic wounds clinically.
C1 [Shao, Pei-Lin] Asia Univ, Dept Nursing, Taichung 41354, Taiwan.
   [Liao, Jiunn-Der; Chen, Yu-Hsing] Natl Cheng Kung Univ, Engn Mat Biomed Applicat Lab, Dept Mat Sci & Engn, Tainan 70101, Taiwan.
   [Liao, Jiunn-Der] Natl Cheng Kung Univ, Int Ctr Wound Repair & Regenerat, Tainan 70101, Taiwan.
   [Wu, Shun-Cheng] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 807378, Taiwan.
   [Wong, Tak-Wah] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Dermatol, Coll Med, Tainan 704, Taiwan.
   [Wong, Tak-Wah] Natl Cheng Kung Univ, Ctr Appl Nanomed, Coll Med, Dept Biochem & Mol Biol, Tainan 70101, Taiwan.
C3 Asia University Taiwan; National Cheng Kung University; National Cheng
   Kung University; Kaohsiung Medical University; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University
RP Liao, JD (通讯作者)，Natl Cheng Kung Univ, Engn Mat Biomed Applicat Lab, Dept Mat Sci & Engn, Tainan 70101, Taiwan.; Liao, JD (通讯作者)，Natl Cheng Kung Univ, Int Ctr Wound Repair & Regenerat, Tainan 70101, Taiwan.
EM m8951016@gmail.com; dliao@mail.ncku.edu.tw; shunchengwu@gmail.com;
   ny69896032000@hotmail.com; Dr.kentwwong@gmail.com
RI Wu, Shun-Cheng/E-2989-2010
OI Wu, Shun-Cheng/0000-0003-4219-3413; WONG, TAK-WAH/0000-0002-0131-7339
FU Ministry of Science and Technology of Taiwan [MOST
   108-2218-E-006-054-MY3, MOST 103-2622-B-006-010-and]; MOST
   [108-2218-E-006-054-MY3]
FX This research was funded by Ministry of Science and Technology of
   Taiwan, grant numbers: MOST 108-2218-E-006-054-MY3 and MOST
   103-2622-B-006-010-and the APC was funded by MOST
   108-2218-E-006-054-MY3.
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NR 61
TC 17
Z9 17
U1 1
U2 22
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 19
AR 10266
DI 10.3390/ijms221910266
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WJ9CN
UT WOS:000709334500001
PM 34638608
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shiels, SM
   Sgromolo, NM
   Wenke, JC
AF Shiels, S. M.
   Sgromolo, N. M.
   Wenke, J. C.
TI Negative pressure wound therapy does not diminish efficacy of topical
   antibiotic powder in a preclinical contaminated wound model
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Local antibiotic therapy; Musculoskeletal infection; Topical antibiotic;
   Orthopaedic trauma
ID SURGICAL SITE INFECTIONS; VANCOMYCIN POWDER; OPEN FRACTURES;
   BONE-CEMENT; DELIVERY; BEADS; TRAUMA; DEPOT; RECONSTRUCTION;
   COMPLICATIONS
AB Aims
   High-energy injuries can result in multiple complications, the most prevalent being infection. Vancomycin powder has been used with increasing frequency in orthopaedic trauma given its success in reducing infection following spine surgery. Additionally, large, traumatic injuries require wound coverage and management by dressings such as negative pressure wound therapy (NPWT). NPWT has been shown to decrease the ability of antibiotic cement beads to reduce infection, but its effect on antibiotic powder is not known. The goal of this study was to determine if NPWT reduces the efficacy of topically applied antibiotic powder.
   Methods
   Complex musculoskeletal wounds were created in goats and inoculated with a strain of Staphylococcus aureus modified to emit light. Six hours after contaminating the wounds, imaging, irrigation, and debridement and treatment application were performed. Animals received either vancomycin powder with a wound pouch dressing or vancomycin powder with NPWT.
   Results
   There were no differences in eradication of bacteria when vancomycin powder was used in combination with NPWT (4.5% of baseline) compared to vancomycin powder with a wound pouch dressing (1.7% of baseline) (p = 0.986), even though approximately 50% of the vancomycin was recovered in the NPWT exudate canister.
   Conclusion
   The antimicrobial efficacy of the vancomycin powder was not diminished by the application of NPWT. These topical and locally applied therapies are potentially effective tools that can provide quick, simple treatments to prevent infection while providing coverage. By reducing the occurrence of infection, the recovery is shortened, leading to an overall improvement in quality of life.
C1 [Shiels, S. M.; Sgromolo, N. M.; Wenke, J. C.] US Army Inst Surg Res, Orthopaed Trauma Res Dept, San Antonio, TX 78234 USA.
   [Sgromolo, N. M.] Brooke Army Med Ctr, Dept Orthopaed Surg, San Antonio, TX USA.
C3 United States Department of Defense; United States Army; United States
   Department of Defense; United States Army; Brooke Army Medical Center
RP Shiels, SM (通讯作者)，US Army Inst Surg Res, Orthopaed Trauma Res Dept, San Antonio, TX 78234 USA.
EM stefanie.m.shiels.civ@mail.mil
FU Orthopaedic Trauma Research Department; Veterinary Support Group
FX The authors would like to thank the Orthopaedic Trauma Research
   Department and the Veterinary Support Group for their support.
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NR 55
TC 7
Z9 11
U1 0
U2 3
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD FEB
PY 2021
VL 10
IS 2
BP 149
EP 155
DI 10.1302/2046-3758.102.BJR-2020-0171.R1
PG 7
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA QQ1NP
UT WOS:000624293500007
PM 33595334
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chan, KS
   Arunaachalam, M
   Hong, QT
   Yong, EM
   Lingam, P
   Zhang, L
   Chandrasekar, S
   Tan, GWL
   Lo, ZJ
AF Chan, Kai Siang
   Arunaachalam, Muthaiah
   Hong, Qiantai
   Yong, En Ming
   Lingam, Pravin
   Zhang, Li
   Chandrasekar, Sadhana
   Tan, Glenn Wei Leong
   Lo, Zhiwen Joseph
TI Outcomes of incisional negative pressure wound therapy following
   brachiobasilic transposition arteriovenous fistula creation: A 1:2
   propensity score matched study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure wound therapy; arteriovenous shunt; surgical;
   arteriovenous fistula; brachiobasilic transposition
ID SURGICAL SITE INFECTION; VASCULAR-SURGERY; PREVENTION; GUIDELINE; RISK
AB Incisional negative wound pressure therapy (iNPWT) use on closed incisions has been shown to improve wound outcomes, but no studies have evaluated the use of iNPWT following brachiobasilic transposition arteriovenous fistula (BBT-AVF). We aim to investigate the efficacy of iNPWT vs conventional wound therapy in reducing surgical site infections (SSIs) for BBT-AVF incisions. This is a retrospective cohort study of patients who underwent BBT-AVF creation between January 2010 and December 2017. A 1:2 propensity score matching (PSM) was performed to reduce selection bias and address for confounding factors. Study outcomes included SSI and haematoma incidence, 30-day readmission, and 30-day mortality. A total of 154 patients were reviewed in this study: 47 (30.5%) had iNPWT and 107 (69.5%) had conventional wound therapy. The overall median age was 60.5 (interquartile range 54-69). PSM with a 1:2 ratio resulted in a total of 117 patients (39 iNPWT and 78 conventional wound therapy). In the unmatched cohort, SSI incidence was lower in the iNPWT group (n = 1/47 [2.1%] vs n = 14/107 [13.1%], P = .035). However, incidence of SSI was comparable between iNPWT and conventional wound therapy after matching (n = 1/39 [2.6%] vs n = 9/78 [11.5%], P = .102). There was no significant difference in 30-day readmission and 30-day mortality. Within our study population of patients with BBT-AVF incisions, there is a non-statistically significant reduction in SSI incidence for patients who received iNPWT as compared with conventional wound therapy. Further prospective randomised controlled studies should be conducted to validate these findings.
C1 [Chan, Kai Siang] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.
   [Arunaachalam, Muthaiah] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Chan, Kai Siang; Arunaachalam, Muthaiah; Hong, Qiantai; Yong, En Ming; Lingam, Pravin; Zhang, Li; Chandrasekar, Sadhana; Tan, Glenn Wei Leong; Lo, Zhiwen Joseph] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
C3 Nanyang Technological University; National University of Singapore; Tan
   Tock Seng Hospital
RP Chan, KS (通讯作者)，Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
EM kchan023@e.ntu.edu.sg
RI ; Yong, Enming/LXB-4566-2024; Lingam, Pravin/ODK-1133-2025
OI Chanasekar, Sadhana/0000-0002-3650-8020; Chan, Kai
   Siang/0000-0001-9533-801X; LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Yong,
   Enming/0000-0002-9461-0066; 
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NR 28
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1231
EP 1238
DI 10.1111/iwj.13376
EA APR 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000529141800001
PM 32347016
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Oh, KS
   Cho, W
   Kim, J
   Kim, KN
AF Oh, Kap Sung
   Cho, Wonseok
   Kim, Junekyu
   Kim, Kyu Nam
TI Clinical Salvage Approaches for Surgical Site Infection After Autologous
   Microtia Reconstruction
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE microtia; surgical wound infection; costal cartilage; negative-pressure
   wound therapy; reconstructive surgical procedures
ID AURICLE; MICROBIOLOGY; EPIDEMIOLOGY; FRAMEWORK
AB Background/Objectives: Surgical site infection (SSI) after autologous rib cartilage microtia reconstruction is an uncommon but potentially devastating complication, as infection of the avascular cartilage framework can rapidly lead to partial or complete framework loss. Traditional management often favored aggressive debridement or framework removal, resulting in significant deformity. This study aimed to evaluate salvage-oriented management strategies and to propose a structured treatment algorithm for SSI following microtia reconstruction. Methods: A retrospective case series was conducted of patients who developed SSI after autologous rib cartilage microtia reconstruction between March 2021 and November 2025. SSI was defined by clinical and surveillance criteria requiring intervention beyond routine postoperative care. Nine patients were included. Management strategies were analyzed with respect to infection control, framework preservation, and wound healing outcomes. Results: SSI occurred at variable time points, ranging from early postoperative infection to delayed and late-onset presentations. Identified pathogens included Gram-positive cocci and multidrug-resistant Gram-negative organisms. Negative-pressure wound therapy (NPWT) was applied in all cases with wound dehiscence, persistent drainage, or cartilage exposure. Conservative staged debridement was performed only after clear demarcation of nonviable tissue. Overall auricular framework preservation was achieved in 100% of patients, with no cases requiring complete framework removal, although limited cartilage loss occurred in select cases. These outcomes demonstrate the clinical feasibility and effectiveness of salvage-oriented management across heterogeneous infection scenarios. Conclusions: SSI following autologous microtia reconstruction can be effectively salvaged without routine framework removal through a structured, timing-based algorithm emphasizing early culture-guided antimicrobial therapy, NPWT, and conservative staged intervention. This salvage-oriented approach provides a clinically relevant and reproducible framework for preserving auricular structure while minimizing morbidity, even in infections involving multidrug-resistant organisms.
C1 [Oh, Kap Sung; Cho, Wonseok; Kim, Junekyu; Kim, Kyu Nam] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Plast & Reconstruct Surg, Seoul 03181, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Samsung Kangbuk
   Hospital
RP Kim, KN (通讯作者)，Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Plast & Reconstruct Surg, Seoul 03181, South Korea.
EM kapsung.oh@samsung.com; wscws26@naver.com; j7181.kim@samsung.com;
   manabear77@naver.com
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   Park C, 2010, ANN PLAS SURG, V65, P197, DOI 10.1097/SAP.0b013e3181c1feff
   Reinisch JF, 2020, PLAST RECONSTR SURG, V145, P1252, DOI 10.1097/PRS.0000000000006766
   Rezaei AR, 2025, J TRAUMA INJ, V38, DOI 10.20408/jti.2025.0019
   Saadi RA, 2021, INT J PEDIATR OTORHI, V146, DOI 10.1016/j.ijporl.2021.110733
   Sasaki K, 2021, J PLAST RECONSTR AES, V74, P1380, DOI 10.1016/j.bjps.2020.11.010
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   Youbong TJ, 2021, ANTIBIOTICS-BASEL, V10, DOI 10.3390/antibiotics10121513
NR 28
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN 29
PY 2026
VL 15
IS 3
AR 1064
DI 10.3390/jcm15031064
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DN8PM
UT WOS:001687864300001
PM 41682743
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yamamoto, R
   Kuramoto, S
   Shimizu, M
   Shinozaki, H
   Miyake, T
   Sadakari, Y
   Sekine, K
   Kaneko, Y
   Kurosaki, R
   Koizumi, K
   Shibusawa, T
   Sakurai, Y
   Wakahara, S
   Sasaki, J
AF Yamamoto, Ryo
   Kuramoto, Shunsuke
   Shimizu, Masayuki
   Shinozaki, Hiroharu
   Miyake, Tasuku
   Sadakari, Yoshihiko
   Sekine, Kazuhiko
   Kaneko, Yasushi
   Kurosaki, Ryo
   Koizumi, Kiyoshi
   Shibusawa, Takayuki
   Sakurai, Yoshihiko
   Wakahara, Sota
   Sasaki, Junichi
CA OPTITAC study grp
TI Optimal tentative abdominal closure for open abdomen: a multicenter
   retrospective observational study (OPTITAC study)
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE abdominal sepsis; damage control surgery; fascia closure; high negative
   pressure; negative-pressure wound therapy
ID PRESSURE WOUND THERAPY; EARLY FASCIAL CLOSURE; EASTERN ASSOCIATION;
   PROGNOSTIC-FACTORS; MANAGEMENT; TRAUMA; SURGERY; EVOLUTION; WALL
AB Background: Primary fascia closure is often difficult following an open abdomen (OA). While negative-pressure wound therapy (NPWT) is recommended to enhance successful primary fascia closure, the optimal methods and degree of negative pressure remain unclear. This study aimed to elucidate optimal methods of NPWT as a tentative abdominal closure for OA to achieve primary abdominal fascia closure.Materials and Methods: A multicenter, retrospective, cohort study of adults who survived OA greater than 48 h was conducted in 12 institutions between 2010 and 2022. The achievement of primary fascia closure and incidence of enteroatmospheric fistula were examined based on methods (homemade, superficial NPWT kit, or open-abdomen kit) or degrees of negative pressure (<50, 50-100, or >100 mmHg). A generalized estimating equation was used to adjust for age, BMI, comorbidities, etiology for laparotomy requiring OA, vital signs, transfusion, severity of critical illness, and institutional characteristics.Results: Of the 279 included patients, 252 achieved primary fascia closure. A higher degree of negative pressure (>100 mmHg) was associated with fewer primary fascia closures than less than 50 mmHg [OR, 0.18 (95% CI: 0.50-0.69), P=0.012] and with more frequent enteroatmospheric fistula [OR, 13.83 (95% CI: 2.30-82.93)]. The methods of NPWT were not associated with successful primary fascia closure. However, the use of the open-abdomen kit was related to a lower incidence of enteroatmospheric fistula [OR, 0.02 (95% CI: 0.00-0.50)].Conclusion: High negative pressure (>100 mmHg) should be avoided in NPWT during tentative abdominal closure for OA.
C1 [Yamamoto, Ryo] Keio Univ, Sch Med, Dept Emergency & Crit Care Med, Tokyo, Japan.
   [Sekine, Kazuhiko; Wakahara, Sota] Tokyo Saiseikai Cent Hosp, Dept Emergency & Crit Care Med, Tokyo, Japan.
   [Shibusawa, Takayuki] Tokyo Med Ctr, Dept Emergency & Crit Care Med, Natl Hosp Org, Tokyo, Japan.
   [Sasaki, Junichi] St Marys Hosp, Dept Surg, Fukuoka, Japan.
   [Sadakari, Yoshihiko] Kenwakai Otemachi Hosp, Dept Surg, Fukuoka, Japan.
   [Kuramoto, Shunsuke; Miyake, Tasuku] Shimane Univ, Fac Med, Dept Acute Care Surg, Izumo, Shimane, Japan.
   [Kurosaki, Ryo] Japanese Red Cross Maebashi Hosp, Dept Surg, Fukuoka, Gunma, Japan.
   [Koizumi, Kiyoshi] Ashikaga Red Cross Hosp, Dept Cardiovasc Surg, Ashikaga, Tochigi, Japan.
   [Shinozaki, Hiroharu] Saiseikai Utsunomiya Hosp, Dept Surg, Utsunomiya, Tochigi, Japan.
   [Sakurai, Yoshihiko] Shonantobe Gen Hosp, Dept Surg, Yokosuka, Kanagawa, Japan.
   [Shimizu, Masayuki] Saiseikai Yokohamashi Tobu Hosp, Dept Trauma & Emergency Surg, Yokohama, Kanagawa, Japan.
   [Kaneko, Yasushi] Hiratsuka City Hosp, Dept Emergency & Crit Care Med, Hiratsuka, Kanagawa, Japan.
   [Yamamoto, Ryo] Keio Univ, Dept Emergency & Crit Care Med, Trauma Serv, Sch Med, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
C3 Keio University; Tokyo Saiseikai Central Hospital; Shimane University;
   Keio University
RP Yamamoto, R (通讯作者)，Keio Univ, Dept Emergency & Crit Care Med, Trauma Serv, Sch Med, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
EM ryo.yamamoto@gmail.com; s-kura@med.shimane-u.ac.jp;
   masayukizc4@gmail.com; hiroharu_shinozaki@saimiya.com;
   tasukun.0130@kenwakai.gr.jp; Y.Sadakari@gmail.com; skkazoo@yahoo.co.jp;
   y-kaneko0523@hotmail.co.jp; kuro3@k7.dion.ne.jp;
   kkoizumimed1023@gmail.com; takayukishibusawa@gmail.com;
   syoshi88801@yahoo.co.jp; soutamugen@gmail.com;
   sasakij@1989.jukuin.keio.ac.jp
RI ; Sasaki, Junichi/E-6992-2016; Yamamoto, Ryo/J-8017-2019; /C-5622-2011
OI Miyake, Tasuku/0009-0007-6339-7200; Wakahara, Sota/0009-0007-4827-6398; 
FU Japanese Society for Abdominal Emergency Medicine [2020-P-05]
FX This study received a research grant from the Japanese Society for
   Abdominal Emergency Medicine (2020-P-05).
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NR 32
TC 2
Z9 4
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD DEC
PY 2023
VL 109
IS 12
BP 4049
EP 4056
DI 10.1097/JS9.0000000000000687
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CK3M9
UT WOS:001125107900047
PM 37678286
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Steele, AW
   Miller, NF
   Wallace, SJ
   Hume, KM
   Sommers, CA
   Simmons, CJ
   Murphy, RX 
AF Steele, Andrew W.
   Miller, Nathan F.
   Wallace, Sean J.
   Hume, Keith M.
   Sommers, Catherine A.
   Simmons, Christopher J.
   Murphy, Robert X., Jr.
TI Hidradenitis Suppurativa: A Comparison of Institutional Experience and
   the Tracking Operations and Outcomes for Plastic Surgeons Registry
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Plastic Surgery The Meeting / 88th Annual Meeting of the
   American-Society-of-Plastic-Surgeons (ASPS)
CY SEP 20-23, 2019
CL San Diego, CA
SP Amer Soc Plast Surg
ID NEGATIVE-PRESSURE DRESSINGS; SURGICAL-TREATMENT; RADICAL EXCISION;
   MANAGEMENT; CLOSURE; FLAP
AB Background: Hidradenitis suppurativa is a chronic inflammatory dermatologic condition occurring most commonly in areas with large numbers of apocrine sweat glands. Surgical excision and wound reconstruction are indicated for severe or refractory disease. This study aims to explore institutional reconstructive outcomes following hidradenitis suppurativa excision and compare these to the nationally recognized Tracking Operations and Outcomes for Plastic Surgeons (TOPS) database to determine best-practice guidelines. Methods: A retrospective chart review of all patients with surgically treated hidradenitis suppurativa from January of 2004 to January of 2016 was performed. Data on patient characteristics, reconstructive methods, and outcomes were collected. Outcomes for each reconstructive method were analyzed and associations between reconstruction and complications were determined. These results were compared to TOPS data. Results: A total of 382 operative sites for 101 individual patients were reviewed. Overall complication rates were 80, 68.3, and 59.6 percent for simple, intermediate, and complex closure, respectively; 68.3 percent for adjacent soft-tissue rearrangement; and 100 percent for split-thickness skin grafts and perforator flaps. Statistical significance was identified between superficial wound dehiscence and adjacent tissue rearrangement compared to intermediate and complex closure (p = 0.0132). TOPS data revealed similar wound breakdown rates for primary closure methods but much lower rates with negative-pressure wound therapy, split-thickness skin grafts, and muscle flaps. Conclusions: Primary closure techniques for hidradenitis suppurativa wound reconstruction possess high complication rates, whereas improved outcomes are observed with negative-pressure wound therapy, split-thickness skin grafts, and muscle flaps. The correlation in outcomes between our experience and that reported in the TOPS database provides a level of validation to this national database.
C1 [Steele, Andrew W.] Lehigh Valley Hlth Network, Div Plast Surg, 1200 South Cedar Crest Blvd, Allentown, PA 18103 USA.
   Amer Soc Plast Surg, San Diego, CA USA.
C3 Lehigh Valley Health Network
RP Steele, AW (通讯作者)，Lehigh Valley Hlth Network, Div Plast Surg, 1200 South Cedar Crest Blvd, Allentown, PA 18103 USA.
EM andrew.steele15@gmail.com
RI Murphy, Robert/HPC-2683-2023; /HRA-3825-2023
CR Alharbi Z, 2012, BMC DERMATOL, V12, DOI 10.1186/1471-5945-12-9
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   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Bohn J, 2001, SCAND J PLAST RECONS, V35, P305
   Buimer MG, 2009, BRIT J SURG, V96, P350, DOI 10.1002/bjs.6569
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NR 25
TC 10
Z9 13
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2022
VL 149
IS 5
BP 1216
EP 1224
DI 10.1097/PRS.0000000000009024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 0V1QF
UT WOS:000788119300054
PM 35311802
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Comparative study of the microvascular blood flow in the intestinal
   wall, wound contraction and fluid evacuation during negative pressure
   wound therapy in laparostomy using the VAC abdominal dressing and the
   ABThera open abdomen negative pressure therapy system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE ABThera; Fluid evacuation; Microvascular blood flow; NPWT; Open abdomen;
   VAC
ID ASSISTED CLOSURE; COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION;
   PROTECTIVE DISC; RECOMMENDATIONS; SEPSIS
AB To compare the changes in microvascular blood flow in the small intestinal wall, wound contraction and fluid evacuation, using the established V.A.C. abdominal dressing (VAC dressing) and a new abdominal dressing, the ABThera open abdomen negative pressure therapy system (ABThera dressing), in negative pressure wound therapy (NPWT). Midline incisions were made in 12 pigs, which were subjected to treatment with NPWT using the VAC or ABThera dressing. The microvascular blood flow in the intestinal wall, were measured before and after the application at topical negative pressures of -50, -75 and -125 mmHg, using laser Doppler velocimetry. Wound contraction and fluid evacuation were also measured. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 646 +/- 67% (P < 005) after the application of -50 mmHg using the VAC dressing, and to 653 +/- 96% (P < 005) after the application of -50 mmHg with the ABThera dressing. The blood flow was significantly reduced, to 396 +/- 67% (P < 005) after the application of -125 mmHg using VAC, and to 405 +/- 62% (P < 005) after the application of -125 mmHg with ABThera. No significant difference in the reduction in blood flow could be observed between the two groups. The ABThera system gave significantly better fluid evacuation from the wound compared to the VAC system. There was no difference between the dressings regarding the reduction in blood flow, but the ABThera dressing afforded better drainage of the abdomen and better wound contraction than the VAC dressing.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, SE-22185 Lund, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Lindstedt, S (通讯作者)，Lund Univ, SUS, Skane Univ Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@med.lu.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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   Lindstedt S, 2012, BMC SURG, V12, DOI 10.1186/1471-2482-12-4
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NR 18
TC 20
Z9 22
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 83
EP 88
DI 10.1111/iwj.12056
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700014
PM 23517436
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Hansen, E
   Durinka, JB
   Costanzo, JA
   Austin, MS
   Deirmengian, GK
AF Hansen, Erik
   Durinka, Joel B.
   Costanzo, James A.
   Austin, Matthew S.
   Deirmengian, Gregory K.
TI Negative Pressure Wound Therapy Is Associated With Resolution of
   Incisional Drainage in Most Wounds After Hip Arthroplasty
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID TOTAL KNEE ARTHROPLASTY; CLOSED SURGICAL INCISIONS; ASSISTED CLOSURE
   DEVICE; MANAGEMENT; INFECTION; FRACTURES; EFFICACY; TRAUMA
AB Persistent wound drainage after hip arthroplasty is a risk factor for periprosthetic infection. Negative pressure wound therapy (NPWT) has been used in other fields for wound management although it is unclear whether the technique is appropriate for total hip arthroplasty.
   We determined (1) the rate of wound complications related to use of NPWT for persistent incisional drainage after hip arthroplasty; (2) the rate of resolution of incisional drainage using this modality; and (3) risk factors for failure of NPWT for this indication.
   In a pilot study we identified 109 patients in whom NPWT was used after hip arthroplasty for treating postoperative incisional drainage between April 2006 and April 2010. On average, the NPWT was placed on postoperative Day 3 to 4 (range, 2-9 days) and applied for 2 days (range, 1-10 days). We then determined predictors of subsequent surgery. Patients were followed until failure or a minimum of 1 year (average, 29 months; range, 1-62 months).
   Eighty-three patients (76%) had no further surgery and 26 patients (24%) had subsequent surgery: 11 had superficial irrigation and d,bridement (I&D), 12 had deep I&D with none requiring further surgery, and three ultimately had component removal. Predictors of subsequent surgery included international normalized ratio level greater than 2, greater than one prior hip surgery, and device application greater than 48 hours. There were no wound-related complications associated with NPWT.
   The majority of our patients had cessation of wound drainage with NPWT.
   Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
C1 [Hansen, Erik; Durinka, Joel B.; Costanzo, James A.; Austin, Matthew S.; Deirmengian, Gregory K.] Thomas Jefferson Univ Hosp, Rothman Inst Orthopaed, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Rothman Institute
RP Deirmengian, GK (通讯作者)，Thomas Jefferson Univ Hosp, Rothman Inst Orthopaed, 925 Chestnut St,5th Floor, Philadelphia, PA 19107 USA.
EM kirkor8@yahoo.com
RI Austin, Matthew/CAI-5870-2022
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NR 25
TC 40
Z9 50
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD OCT
PY 2013
VL 471
IS 10
BP 3230
EP 3236
DI 10.1007/s11999-013-2937-3
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 216YU
UT WOS:000324323900029
PM 23539123
DA 2026-07-24
ER

EF