﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Horch, RE
AF Horch, RE
TI Changing paradigms in reconstructive surgery by vacuum therapy?
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE changing paradigms; reconstructive surgery; vacuum therapy
ID ASSISTED CLOSURE THERAPY; NEGATIVE-PRESSURE DRESSINGS; BURN WOUND
   PROGRESSION; SUBATMOSPHERIC PRESSURE; STERNAL WOUNDS; SOFT-TISSUE; OPEN
   ABDOMEN; DEFINITIVE CLOSURE; SUCTION DRAINAGE; FASCIAL CLOSURE
AB In modern science the changes of scientific paradigm occur constantly and often unnoticed. Effects of new therapy procedures that are not compatible with the prevailing doctrines first lead to contradictory discussions and may then lead to new doctrines depending upon the general perception. Continuous computer-assisted local negative pressure therapy (vacuum assisted closure therapy/V.A.C.(R), topical negative pressure treatment) has led to unexpected and impressing clinical results since its introduction. This has provoked a recognizable change of different therapeutic concepts in reconstructive surgery. Based on a selection of important clinical examples from reconstructive surgery following a current literature research the attempt is undertaken to point out recognizable changes of paradigms within the treatment algorithms that can be discerned after the the introduction of vacuum therapy in recent years.
C1 Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 77
TC 13
Z9 13
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S44
EP S49
DI 10.1055/s-2006-921462
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100012
PM 16575645
DA 2026-07-24
ER

PT J
AU Sano, H
   Kajikawa, A
   Ueda, K
AF Sano, Hitomi
   Kajikawa, Akiyoshi
   Ueda, Kazuki
TI Study of continuous irrigation negative-pressure treatment using an
   original ulceration model
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Chronic wound; infection; irrigation
ID VACUUM-ASSISTED CLOSURE; INFECTIONS; WOUNDS
AB A continuous irrigation with intermittent aspiration (CIIA) method has previously been developed in the treatment of infected expander sites. For the purpose of treatment of infected wounds, a new intermittent negative pressure irrigation treatment (INPIT) has been developed that is a combination of CIIA with topical negative-pressure therapy. This study aims to investigate the efficacy of INPIT. The efficacy of irrigation was investigated by changing the conditions including the location and the number of irrigation tubes, flow volume, and the timetable of negative-pressure application using original ulcer models. Although the presence of side holes and increase in the number of tubes or flow volume improved the irrigation efficacy, non-washed-out areas remained. On the other hand, INPIT allowed more uniform and wide area washing even at low flow volume. The results suggest that INPIT is superior to general conventional continuous irrigation treatment in irrigation efficiency.
C1 [Sano, Hitomi; Kajikawa, Akiyoshi; Ueda, Kazuki] Fukushima Med Univ, Dept Plast & Reconstruct Surg, Fukushima 96001295, Japan.
RP Kajikawa, A (通讯作者)，Fukushima Med Univ, Dept Plast & Reconstruct Surg, 1 Hikarigaoka, Fukushima 96001295, Japan.
EM sasasa116sasasa@hotmail.com
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NR 13
TC 1
Z9 2
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD JUN
PY 2013
VL 47
IS 3
BP 175
EP 179
DI 10.3109/2000656X.2012.747961
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 144LO
UT WOS:000318941000003
PM 23676011
OA gold
DA 2026-07-24
ER

PT J
AU Stynes, G
   Kiroff, GK
   Morrison, WAJ
   Kirkland, MA
AF Stynes, Gil
   Kiroff, George K.
   Morrison, Wayne A. J.
   Kirkland, Mark A.
TI Tissue compatibility of biomaterials: Benefits and problems of skin
   biointegration
SO ANZ JOURNAL OF SURGERY
LA English
DT Review
DE biocompatible materials; prostheses and implants; reconstructive
   surgical procedure; tantalum; titanium
ID VACUUM-ASSISTED CLOSURE; HUMAN LYMPHOBLASTOID-CELLS; SELF-ASSEMBLED
   MONOLAYERS; OXIDE SURFACES; IN-VITRO; INFLAMMATORY RESPONSE; SOLUBLE
   LAMININ-5; TITANIUM SURFACES; EPITHELIAL-CELLS; IMPLANTS
AB The integration of biomaterials with skin is necessary to enable infection-free access to vasculature and body cavities. Also, integrating plastics and metals with skin increases options for the reconstruction of surgical and traumatic defects and enables the permanent implantation of robotic and electronic devices. Until now, attempts to integrate biomaterials with skin permanently have failed because of epidermal marsupialization and infection. This article reviews the general properties required of biomaterials to optimize integration with body tissues, the modifications that increase biocompatibility, focusing particularly on surface functionalization and the specific requirements for biomaterial integration into skin. Critical pathophysiological processes relating to biocompatibility are discussed with particular emphasis on the skin-biomaterial interface. Future directions are speculated on, in particular, the specific utility of subatmospheric pressure dressings in facilitating tissue integration into biomaterials.
C1 [Stynes, Gil] Geelong Hosp, Dept Clin & Biomed Sci, Geelong, Vic 3220, Australia.
   [Stynes, Gil; Kirkland, Mark A.] Univ Melbourne, Dept Clin & Biomed Sci, Melbourne, Vic, Australia.
   [Stynes, Gil; Kirkland, Mark A.] Deakin Univ, Inst Biotechnol BioDeakin, Geelong, Vic 3217, Australia.
   [Morrison, Wayne A. J.] Bernard OBrien Inst Microsurg, Fitzroy, Vic, Australia.
C3 Barwon Health; Geelong Hospital; University of Melbourne; Deakin
   University
RP Stynes, G (通讯作者)，Geelong Hosp, Dept Clin & Biomed Sci, Ryrie St, Geelong, Vic 3220, Australia.
EM gstynes@gmail.com
OI Stynes, Gil/0000-0003-3263-7754
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NR 67
TC 12
Z9 17
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD AUG
PY 2008
VL 78
IS 8
BP 654
EP 659
DI 10.1111/j.1445-2197.2008.04609.x
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 336GZ
UT WOS:000258353600012
PM 18796021
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Tachi, M
   Hirabayashi, S
   Yonehara, Y
   Uchida, G
   Tohyama, T
   Ishii, H
AF Tachi, M
   Hirabayashi, S
   Yonehara, Y
   Uchida, G
   Tohyama, T
   Ishii, H
TI Topical negative pressure using a drainage pouch without foam dressing
   for the treatment of undermined pressure ulcers
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE topical negative pressure; pressure ulcer; undermining
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB Topical negative pressure is gaining popularity as an acute and chronic wound management technique. In general, foam dressing is applied to the wound surface to maintain negative pressure. Due to the potential for clogging by the foam dressing, topical negative pressure cannot be used when there is a high volume of necrotic tissue or massive infection present. In this study, topical negative pressure was applied using a drainage pouch without any dressing. Topical negative pressure was applied to 8 patients with 9 pressure ulcers complicated by undermining. This approach was effective in the treatment of all 9 ulcers and allowed the wounds to be visualized while maintaining negative pressure. Since this technique can be performed without foam dressing, it can be used to treat early-stage infectious pressure ulcers in which there is a lot of necrotic tissue.
   Conclusion: Topical negative pressure without dressing is an extremely effective treatment of pressure ulcers complicated by undermining.
C1 Teikyo Univ, Sch Med, Dept Plast & Reconstruct Surg, Itabashi Ku, Tokyo 1738605, Japan.
C3 Teikyo University
RP Tachi, M (通讯作者)，Teikyo Univ, Sch Med, Dept Plast & Reconstruct Surg, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM tachi@med.teikyo-u.ac.jp
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NR 16
TC 12
Z9 20
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2004
VL 53
IS 4
BP 338
EP 342
DI 10.1097/01.sap.0000129234.84192.d4
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 859ZA
UT WOS:000224305700007
PM 15385767
DA 2026-07-24
ER

PT J
AU Steinkamp, M
   Gress, TM
AF Steinkamp, Martin
   Gress, Thomas M.
TI Endoscopic Options for the Treatment of Anastomotic Leakages in the
   Rectum
SO VISZERALMEDIZIN
LA German
DT Article
DE Anastomotic leakages; Rectum; Endoscopic treatment
ID LOW ANTERIOR RESECTION; TOTAL MESORECTAL EXCISION; ENDO-SPONGE
   TREATMENT; SCOPE CLIP OTSC; MALIGNANT COLONIC OBSTRUCTION; EXPANDABLE
   METALLIC STENT; RISK-FACTORS; FIBRIN GLUE; GASTROINTESTINAL ANASTOMOSES;
   FISTULAS SECONDARY
AB Background: Anastomotic leakages are severe complications in colorectal surgery. Endoscopic treatment techniques have been increasingly established. In this article we present an overview of the most frequently used endoscopic techniques. Methods: Systematic review of the literature. Results: The most relevant endoscopic procedures for the treatment of colorectal anastomotic leakages comprise the injection of fibrin glue, vacuum-assisted closure systems, over-the-scope clips (OTSC), and implantation of self-expanding metal stents. In contrast to the frequent use of these techniques in clinical practice, there is a paucity of evidence from controlled clinical trials supporting the various endosopic techniques. Conclusion: The clinical value of the different methods is mostly dependent on the investigators' experience. Prospective randomized trials are required to generate a valid data basis for the approaches already used in clinical practice.
C1 [Steinkamp, Martin; Gress, Thomas M.] Univ Klinikum Giessen & Marburg GmbH, Klin Gastroenterol Endokrinol Stoffwechsel Infekt, Standort Marburg, Germany.
C3 University Hospital of Giessen & Marburg
RP Steinkamp, M (通讯作者)，Univ Klinikum Giessen & Marburg GmbH, Klin Gastroenterol Endokrinol Stoffwechsel Infekt, Standort Marburg Baldingerstr, D-35037 Marburg, Germany.
EM steinkam@med.uni-marburg.de
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NR 84
TC 2
Z9 2
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-6664
EI 1662-6672
J9 VISZERALMEDIZIN
JI Viszeralmedizin
PY 2012
VL 28
IS 6
BP 369
EP 375
DI 10.1159/000345837
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 137ZR
UT WOS:000318478300002
DA 2026-07-24
ER

PT J
AU Stannard, JR
   Atkins, BZ
   O'Malley, D
   Singh, H
   Bernstein, B
   Fahey, M
   Masden, D
   Attinger, CE
AF Stannard, James R.
   Atkins, Broadus Zane
   O'Malley, David
   Singh, Hardayal
   Bernstein, Brent
   Fahey, Michael
   Masden, Derek
   Attinger, Christopher E.
TI Use of Negative Pressure Therapy on Closed Surgical Incisions: A Case
   Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE surgical wounds; complications; negative pressure therapy; case study
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; PERISTERNAL THORACIC
   WALL; WOUND THERAPY; BLOOD-FLOW; MULTICENTER
AB Multiple patient comorbidities and environmental factors increase the risk of incisional wound complications. The literature suggests that negative pressure therapy (NPT) on clean closed surgical incisions may help reduce the risk of wound infections and other complications. In this case study, NPT was applied in the operating room to clean closed surgical wounds in four high-risk patients (two men, two women) following coronary artery bypass grafting using bilateral internal mammary arteries, transmetatarsal amputation, and abdominal hysterectomy. All wounds healed well. These results and currently available information suggest that prospective, randomized, controlled clinical studies to assess the safety, efficacy, and cost-effectiveness of NPT in the prevention of postoperative wound complications are warranted. In addition, if studies confirm the validity and reliability of the proposed patient grading system discussed, it may help guide use of NPT in post-surgical patients.
C1 [Stannard, James R.] Univ Alabama Birmingham, Sch Med, Dept Orthopaed Trauma, Birmingham, AL USA.
   [Atkins, Broadus Zane] VA Med Ctr, Durham, NC USA.
   [O'Malley, David] Ohio State Univ, Coll Med, James Canc Ctr, Columbus, OH 43210 USA.
   [O'Malley, David] Ohio State Univ, Coll Med, Solove Res Inst, Columbus, OH 43210 USA.
   [Singh, Hardayal] SE Orthoped Sports Med & Shoulder Ctr, Raleigh, NC USA.
   [Bernstein, Brent] St Lukes Hosp, Podiatr Residency Teaching Facil, Allentown, PA USA.
   [Bernstein, Brent] St Lukes Hosp, Podiatr Residency Teaching Facil, Bethlehem, PA USA.
   [Fahey, Michael] Fremont Rideout Hlth Grp, Yuba City, CA USA.
   [Masden, Derek] Georgetown Univ Hosp, Washington, DC 20007 USA.
   [Attinger, Christopher E.] Georgetown Univ Hosp, Div Plast Surg, Washington, DC 20007 USA.
   [Attinger, Christopher E.] Georgetown Limb Ctr, Washington, DC USA.
C3 University of Alabama System; University of Alabama Birmingham; James
   Cancer Hospital & Solove Research Institute; University System of Ohio;
   Ohio State University; James Cancer Hospital & Solove Research
   Institute; University System of Ohio; Ohio State University; Georgetown
   University; Georgetown University
RP Stannard, JR (通讯作者)，Care of Martinez RR, KCI, Med Dept, San Antonio, TX USA.
RI /AAQ-9524-2020; OMalley, David/E-3789-2011
OI Stannard, James P/0000-0001-8467-6494; OMalley,
   David/0000-0002-2828-0177
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NR 24
TC 71
Z9 77
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD AUG
PY 2009
VL 55
IS 8
BP 58
EP +
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 489PE
UT WOS:000269431900010
PM 19717857
DA 2026-07-24
ER

PT J
AU Zhao, ZK
   Cao, L
   Xu, SJ
   Yang, F
   Gao, S
   Ren, CX
   Xu, XC
   Li, XQ
AF Zhao, Zhikun
   Cao, Lei
   Xu, Shengju
   Yang, Fan
   Gao, Shang
   Ren, Chuanxin
   Xu, Xingchao
   Li, Xiangqi
TI Case Report: Giant undifferentiated pleomorphic sarcoma of the breast
   combined with contralateral high-grade intraductal carcinoma
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE breast cancer; case report; high-grade intraductal carcinoma;
   multidisciplinary treatment; undifferentiated pleomorphic sarcoma
ID AMERICAN JOINT COMMITTEE; SOFT-TISSUE SARCOMA; CANCER; TUMORS;
   CLASSIFICATION; STAGE
AB This article reports an exceptionally rare case of a 43-year-old female presenting with concurrent giant pleomorphic undifferentiated sarcoma and high-grade intraductal carcinoma of the contralateral breast. The tumor, remarkably large and comparable in size to a basketball, presented significant diagnostic and therapeutic challenges. Following a multidisciplinary consultation, the patient underwent a comprehensive treatment regimen, which included left mastectomy, modified radical mastectomy, vacuum-assisted closure (VSD) negative pressure drainage, radiotherapy, and endocrine therapy for the high-grade intraductal carcinoma. Post-treatment follow-up over a period of 2 to 5 years revealed a satisfactory recovery with no evidence of recurrence or metastasis. This case underscores the critical role of a multidisciplinary approach in managing rare and complex breast malignancies and highlights the potential for favorable outcomes even in cases involving exceptionally large tumors.
C1 [Zhao, Zhikun] Shandong First Med Univ, Affiliated Hosp 2, Dept Gen Surg, Tai An, Shandong, Peoples R China.
   [Cao, Lei] Qingdao Univ, Affiliated Taian City Cent Hosp, Dept Breast Surg, Tai An, Shandong, Peoples R China.
   [Xu, Shengju] Shandong First Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Tai An, Shandong, Peoples R China.
   [Yang, Fan] Shandong First Med Univ, Affiliated Hosp 2, Dept Pathol, Tai An, Shandong, Peoples R China.
   [Gao, Shang; Ren, Chuanxin; Xu, Xingchao; Li, Xiangqi] Shandong First Med Univ, Affiliated Hosp 2, Dept Breast Surg, Tai An, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Qingdao University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong First Medical
   University & Shandong Academy of Medical Sciences
RP Xu, XC; Li, XQ (通讯作者)，Shandong First Med Univ, Affiliated Hosp 2, Dept Breast Surg, Tai An, Shandong, Peoples R China.
EM xuxingchao1@163.com; drlixqi@hotmail.com
FU National Natural Science Foundation of China [82274538]; Natural Science
   Foundation of Shandong Province [ZR2020MH357]; Shandong Province Medical
   and Health Technology Development Project [2019WS406]; Shandong Medical
   Association Clinical Research Fund - Qilu Special Project
   [YXH2022ZX02161]; Shandong Province "Traditional Chinese Medicine Plus"
   New Product R&D and Promotion Project
FX The author(s) declared that financial support was received for this work
   and/or its publication. The National Natural Science Foundation of China
   (grant no. 82274538), The Natural Science Foundation of Shandong
   Province (grant no. ZR2020MH357), and Shandong Province Medical and
   Health Technology Development Project (grant no. 2019WS406), Shandong
   Medical Association Clinical Research Fund - Qilu Special Project (grant
   no. YXH2022ZX02161), Shandong Province "Traditional Chinese Medicine
   Plus" New Product R&D and Promotion Project.
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   Voss RK, 2017, ANN SURG ONCOL, V24, P3271, DOI 10.1245/s10434-017-6015-z
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NR 21
TC 0
Z9 0
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD APR 10
PY 2026
VL 16
AR 1633750
DI 10.3389/fonc.2026.1633750
EA APR 2026
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GW8OZ
UT WOS:001746952600001
PM 42038374
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bradbury, S
   Walkley, N
   Ivins, N
   Harding, K
AF Bradbury, Sarah
   Walkley, Neal
   Ivins, Nicola
   Harding, Keith
TI Clinical Evaluation of a Novel Topical Negative Pressure Device in
   Promoting Healing in Chronic Wounds
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; THERAPY; MULTICENTER;
   MANAGEMENT; SYSTEM; ULCERS; LEG; ULCERATION; PROTEASES
AB Aim: This observational study evaluated the use of a novel, ultraportable, mechanically powered topical negative pressure device in promoting healing in chronic wounds, including venous and mixed etiology leg ulcers and neuropathic foot ulcers.
   Materials and Methods: Evaluable patients (n = 37) received treatment with the SNaP (R) Wound Care System for up to 6 weeks. The primary objective was percentage change in wound size, with secondary objectives of clinical assessment of wound parameters, ease of use, and impact on quality of life.
   Results: A 42.64% mean percentage decrease in wound area was observed, with an overall decrease for each wound etiology subgroup. Increased granulation tissue, decreased exudate levels, and decreased wound pain were reported. Quality-of-life scores increased overall, and the device was easy to use, comfortable, portable, and inconspicuous.
   Conclusion: The SNaP Wound Care System has the potential to promote healing in chronic wounds of different etiologies.
C1 [Bradbury, Sarah; Walkley, Neal; Ivins, Nicola; Harding, Keith] Cardiff Univ, Sch Med, Wound Healing Res Unit, Rm 18 UGF,Hlth Pk, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Walkley, N (通讯作者)，Cardiff Univ, Sch Med, Wound Healing Res Unit, Rm 18 UGF,Hlth Pk, Cardiff CF14 4XN, S Glam, Wales.
EM walkleyna@cardiff.ac.uk
RI Bradbury, Sarah/KBR-2907-2024; Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
FU Spiracur Inc.
FX This observational study was supported by funding from Spiracur Inc.
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NR 40
TC 9
Z9 11
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN
PY 2015
VL 4
IS 6
BP 346
EP 357
DI 10.1089/wound.2014.0596
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8YL
UT WOS:000357260600004
PM 26029485
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Mayer, D
   Rancic, Z
   Veith, FJ
   Pecoraro, F
   Pfammatter, T
   Lachat, M
AF Mayer, D.
   Rancic, Z.
   Veith, F. J.
   Pecoraro, F.
   Pfammatter, T.
   Lachat, M.
TI How to diagnose and treat abdominal compartment syndrome after
   endovascular and open repair of ruptured abdominal aortic aneurysms
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Intra-abdominal hypertension; Aortic aneurysm, abdominal; Endovascular
   procedures
ID INTRAABDOMINAL PRESSURE MEASUREMENT; MULTIPLE ORGAN FAILURE;
   CRITICALLY-ILL PATIENTS; DAMAGE-CONTROL LAPAROTOMY; VASCULAR
   SURGICAL-PATIENTS; MEDIATED FASCIAL TRACTION; VACUUM-ASSISTED CLOSURE;
   OPEN ABDOMEN TREATMENT; WOUND CLOSURE; DECOMPRESSIVE LAPAROTOMY
AB Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are frequently encountered in patients treated for ruptured abdominal aortic aneurysms (rAAA) and carry a high morbidity and mortality risk. Despite these facts, IAH/ACS are still overlooked by many physicians, timely diagnosis is missed and treatment often inadequate. All staff involved in the treatment of rAAA should be aware of the risk factors predicting IAH/ACS, the profound implications and derangements on all organ systems, the clinical presentation, the appropriate measurement of intra-abdominal pressure to detect IAH/ACS and the current treatment options for these detrimental syndromes. This comprehensive review provides contemporary knowledge that should help to improve patient survival and long-term outcome.
C1 [Mayer, D.; Rancic, Z.; Lachat, M.] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, Switzerland.
   [Veith, F. J.] Cleveland Clin, New York, NY USA.
   [Veith, F. J.] NYU, Med Ctr, New York, NY 10016 USA.
   [Veith, F. J.] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
   [Pecoraro, F.] P Giaccone Univ Hosp, Vasc Surg Unit, Palermo, Italy.
   [Pfammatter, T.] Univ Zurich Hosp, Dept Intervent Radiol, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; Cleveland Clinic
   Foundation; New York University; University of Zurich; University Zurich
   Hospital; University of Zurich; University Zurich Hospital
RP Mayer, D (通讯作者)，Univ Zurich Hosp, Cardiovasc Surg Clin, Raemistr 100, CH-8091 Zurich, Switzerland.
EM dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Mayer, Dieter/E-7617-2011; PECORARO,
   Felice/H-1434-2018
OI Lachat, Mario/0000-0001-7812-2110; Mayer, Dieter/0000-0001-5933-7749;
   PECORARO, Felice/0000-0001-8165-7490
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NR 117
TC 9
Z9 9
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD APR
PY 2014
VL 55
IS 2
BP 179
EP 192
PG 14
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AH2FJ
UT WOS:000335936600006
PM 24670826
DA 2026-07-24
ER

PT J
AU Medina, ND
   Kovach, SJ
   Levin, LS
AF Medina, Nilton D.
   Kovach, Stephen J., III
   Levin, L. Scott
TI An Evidence-Based Approach to Lower Extremity Acute Trauma
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID FREE-FLAP RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; MICROSURGICAL
   RECONSTRUCTION; LIMB SALVAGE; LOWER LEG; AMPUTATION; DEFECTS; UTILITY;
   WOUNDS; INJURY
AB The Maintenance of Certification module series is designed to help the clinician structure his or her study in specific areas appropriate to his or her clinical practice. This article is prepared to accompany practice-based assessment of preoperative assessment, anesthesia, surgical treatment plan, perioperative management, and outcomes. In this format, the clinician is invited to compare his or her methods of patient assessment and treatment, outcomes, and complications, with authoritative, information-based references.
   This information base is then used for self-assessment and benchmarking in parts II and IV of the Maintenance of Certification process of the American Board of Plastic Surgery. This article is not intended to be an exhaustive treatise on the subject. Rather, it is designed to serve as a reference point for further in-depth study by review of the reference articles presented. (Plast. Reconstr. Surg. 127: 926, 2011.)
C1 [Medina, Nilton D.] Univ Penn, Div Plast Surg, Philadelphia, PA 19104 USA.
   Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Medina, ND (通讯作者)，Univ Penn, Div Plast Surg, 3400 Spruce St,10 Penn Tower, Philadelphia, PA 19104 USA.
EM niltonmedinamd@gmail.com
CR [Anonymous], CRIT APPR SKILLS PRO
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NR 31
TC 29
Z9 30
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD FEB
PY 2011
VL 127
IS 2
BP 926
EP 931
DI 10.1097/PRS.0b013e3182046a16
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 715XJ
UT WOS:000286928100055
PM 21285798
DA 2026-07-24
ER

PT J
AU Randall, KL
   Booth, BA
   Miller, AJ
   Russell, CB
   Laughlin, RT
AF Randall, Kyle L.
   Booth, Branyan A.
   Miller, Adrian J.
   Russell, Corey B.
   Laughlin, Richard T.
TI Use of an acellular regenerative tissue matrix in combination with
   vacuum-assisted closure therapy for treatment of a diabetic foot wound
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE acellular regenerative tissue matrix; chronic wound; diabetes; foot
   ulcer; skin graft; wound vacuum
AB Diabetic foot ulcers can be difficult to treat for a variety of reasons, and may result in amputation. The use of skin grafts can often be a useful method of achieving wound coverage and subsequent healing of diabetic foot ulcers; however, this method of treatment requires creation of a donor site wound that adds to the patient's overall wound burden. Application of an acellular regenerative tissue matrix may eliminate the need for harvesting a skin graft in order to cover a nonhealing wound. The use of vacuum-assisted wound closure has been shown to promote an environment that enhances wound bed contraction and surface epithelialization. The combination of an acellular regenerative tissue matrix with vacuum-assisted wound closure can be used to promote healing in the management of a nonhealing diabetic foot wound.
C1 [Laughlin, Richard T.] Wright State Univ, Boonsholt Sch Med, Dept Orthopaed Surg Sports Med & Rehabil, Dayton, OH 45409 USA.
   [Booth, Branyan A.] Wright State Univ Phys, Dayton, OH USA.
   [Miller, Adrian J.] Miami Valley Hosp Enterostomal Therapy, Continence CNVOCN, Dayton, OH USA.
   [Laughlin, Richard T.] Miami Valley Hosp Foot & Ankle Care Ctr, Dayton, OH USA.
   [Laughlin, Richard T.] Wright State Univ, Dept Orthopaed Sport Med & Rehabil, Dayton, OH 45409 USA.
C3 University System of Ohio; Wright State University Dayton; University
   System of Ohio; Wright State University Dayton; Miami Valley Hospital;
   Miami Valley Hospital; University System of Ohio; Wright State
   University Dayton
RP Laughlin, RT (通讯作者)，Wright State Univ, Boonsholt Sch Med, Dept Orthopaed Surg Sports Med & Rehabil, 30 E Apple St, Suite 2200, Dayton, OH 45409 USA.
EM Richard.laughlin@wright.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Brigido SA, 2004, ORTHOPEDICS, V27, pS145
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
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NR 10
TC 14
Z9 30
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD SEP-OCT
PY 2008
VL 47
IS 5
BP 430
EP 433
DI 10.1053/j.jfas.2008.04.012
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 350IV
UT WOS:000259346900009
PM 18725123
DA 2026-07-24
ER

PT J
AU Repta, R
   Ford, R
   Hoberman, L
   Rechner, B
AF Repta, R
   Ford, R
   Hoberman, L
   Rechner, B
TI The use of negative-pressure therapy and skin grafting in the treatment
   of soft-tissue defects over the Achilles tendon
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE Achilles; wound; reconstructions; negative-pressure therapy
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; WOUNDS
AB Management of soft-tissue defects over the Achilles tendon presents specific challenges to the plastic surgeon. Primary closure or local flaps are often not feasible repair options or such wounds, and many of these patients may be poor candidates for free-tissue transfer secondary to their comorbidity. In this case series, the use of negative-pressure therapy in the preoperative period to prepare the wound bed for placement of a split-thickness skin graft and in the immediate postoperative period as a dressing for the graft was successfully used in 3 patients with soft-tissue defects over the Achilles tendon with exposed tendon. All 3 patients had stable wounds at 48 to 80 months postoperatively. Negative-pressure therapy and skin grafting was found to be a reliable method of repair that provided stable coverage for such wounds.
C1 GRAMEC, Div Plast Surg, Grand Rapids, MI USA.
C3 Michigan State University; Michigan State University Hospital
RP Repta, R (通讯作者)，221 Michigan St,NE,Suite 200A, Grand Rapids, MI 49503 USA.
EM remusreptamd@hotmail.com
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NR 8
TC 23
Z9 28
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2005
VL 55
IS 4
BP 367
EP 370
DI 10.1097/01.sap.0000181342.25065.60
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 970CM
UT WOS:000232282800007
PM 16186700
DA 2026-07-24
ER

PT J
AU Demetriades, D
AF Demetriades, Demetrios
TI Total management of the open abdomen
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal compartment syndrome; Damage control; Negative pressure
   therapy; Open abdomen
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; FASCIAL CLOSURE;
   PACK TECHNIQUE; THERAPY
AB The management of complex abdominal problems with the open abdomen (OA) technique has become a routine procedure in surgery. The number of cases treated with an OA has increased dramatically because of the popularisation of damage control for life-threatening conditions, recognition and treatment of intra-abdominal hypertension and abdominal compartment syndrome and new evidence regarding the management of severe intra-abdominal sepsis. Although OA has saved numerous lives and has addressed many problems related to the primary pathology, this technique is also associated with serious complications. New knowledge about the pathophysiology of the OA and the development of new technologies for temporary abdominal wall closure (e.g. ABThera (TM) Open Abdomen Negative Pressure Therapy; KCI USA Inc., San Antonio, TX) has helped improve the management and outcomes of these patients. This review will merge expert physician opinion with scientific evidence regarding the total management of the OA.
C1 Univ So Calif, Keck Sch Med, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, Los Angeles, CA 90033 USA.
C3 University of Southern California
RP Demetriades, D (通讯作者)，Univ So Calif, Keck Sch Med, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, 1510 San Pablo St,HCC 514, Los Angeles, CA 90033 USA.
EM demetria@usc.edu
FU Kinetic Concepts Inc.
FX Dr DD has a consulting agreement with Kinetic Concepts, Inc. This
   article is part of an educational supplement funded by Kinetic Concepts
   Inc. to provide an overview of the V.A.C.(R) Therapy family of products
   for new users in developing markets.
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NR 26
TC 62
Z9 71
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2012
VL 9
SU 1
SI SI
BP 17
EP 24
DI 10.1111/j.1742-481X.2012.01018.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 962UX
UT WOS:000305573000004
PM 22727136
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Horn, PL
   Ruth, B
   Kean, JR
AF Horn, Pamela Lee
   Ruth, Brenda
   Kean, John R.
TI Use of wound VAC therapy in pediatric patients with infected spinal
   wounds - A retrospective review
SO ORTHOPAEDIC NURSING
LA English
DT Article
ID FUSION; INSTRUMENTATION; MANAGEMENT; CLOSURE
AB BACKGROUND: Deep wound infection in patients that have had a posterior spinal fusion for scoliosis is a major complication in pediatric spine surgery.
   PURPOSE: To explore characteristics of pediatric patients who had a posterior spinal fusion with segmental spinal instrumentation and bone graft and subsequently developed deep spinal wound infections that were treated with wound vacuum-assisted closure (V.A.C.) therapy
   METHOD: Retrospective Chart Review. Characteristics of patients' age, gender, comorbid illnesses, identified bacteria, antibiotics, time on V.A.C. device, infection recurrence, any instrumentation removal, and additional surgical intervention was collected.
   FINDINGS: There were 249 patients who had spinal fusions from December 2002 through January 2006, and 11 developed an infection after their spinal fusion and had the use of the V.A.C. device. Those who developed infection within 1 year of their fusion had instrument retention. Wound closure occurred in all cases that used V.A.C. therapy.
C1 Columbus Childrens Hosp, Dept Orthopaed, Clin Serv Care Coordinat, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital
RP Horn, PL (通讯作者)，Columbus Childrens Hosp, Dept Orthopaed, Clin Serv Care Coordinat, Columbus, OH USA.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   MASSIE JB, 1992, CLIN ORTHOP RELAT R, P99
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   YUANINNES MJ, 2001, SPINE
NR 10
TC 14
Z9 17
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0744-6020
J9 ORTHOP NURS
JI Orthop. Nurs.
PD SEP-OCT
PY 2007
VL 26
IS 5
BP 317
EP 322
DI 10.1097/01.NOR.0000295960.94450.69
PG 6
WC Nursing; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Orthopedics
GA 216VM
UT WOS:000249907100008
PM 17921893
DA 2026-07-24
ER

PT J
AU Huang, H
   Xin, RJ
   Li, XL
   Zhang, XY
   Chen, ZJ
   Zhu, QA
   Tai, ZG
   Bao, LL
AF Huang, Hao
   Xin, Rujuan
   Li, Xiaolong
   Zhang, Xinyue
   Chen, Zhongjian
   Zhu, Quangang
   Tai, Zongguang
   Bao, Leilei
TI Physical therapy in diabetic foot ulcer: Research progress and clinical
   application
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE diabetes foot ulcer; electrical stimulation; medical expenses;
   photobiomodulation therapy; physical therapy
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED-CLOSURE; PRESSURE WOUND
   THERAPY; ELECTRICAL-STIMULATION; SURGICAL-TREATMENT; LASER IRRADIATION;
   PHOTOBIOMODULATION; MANAGEMENT; INTERVENTIONS; MULTICENTER
AB Diabetes foot ulcer (DFU) is one of the most intractable complications of diabetes and is related to a number of risk factors. DFU therapy is difficult and involves long-term interdisciplinary collaboration, causing patients physical and emotional pain and increasing medical costs. With a rising number of diabetes patients, it is vital to figure out the causes and treatment techniques of DFU in a precise and complete manner, which will assist alleviate patients' suffering and decrease excessive medical expenditure. Here, we summarised the characteristics and progress of the physical therapy methods for the DFU, emphasised the important role of appropriate exercise and nutritional supplementation in the treatment of DFU, and discussed the application prospects of non-traditional physical therapy such as electrical stimulation (ES), and photobiomodulation therapy (PBMT) in the treatment of DFU based on clinical experimental records in ClinicalTrials.gov.
C1 [Huang, Hao; Li, Xiaolong; Chen, Zhongjian; Zhu, Quangang; Bao, Leilei] Bengbu Med Coll, Sch Pharm, Bengbu, Anhui, Peoples R China.
   [Huang, Hao; Xin, Rujuan; Li, Xiaolong; Zhang, Xinyue; Chen, Zhongjian; Zhu, Quangang; Tai, Zongguang] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Shanghai, Peoples R China.
   [Huang, Hao; Zhang, Xinyue; Bao, Leilei] Naval Med Univ, Affiliated Hosp 3, Dept Pharm, Shanghai, Peoples R China.
C3 Bengbu Medical University; Tongji University; Naval Medical University
RP Tai, ZG (通讯作者)，Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Shanghai, Peoples R China.; Bao, LL (通讯作者)，Naval Med Univ, Affiliated Hosp 3, Dept Pharm, Shanghai, Peoples R China.
EM taizongguang@163.com; annabao212@126.com
RI /ABI-7110-2020
FU Science and Technology Commission of Shanghai Municipality [19401900700,
   21140901900, 20DZ2255200, 22S2190270, 21S21900900, 20S21901200] Funding
   Source: Medline; Special Plan for Innovation and Generation of Military
   Medical Support Capability [20WQ011] Funding Source: Medline
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NR 144
TC 19
Z9 30
U1 2
U2 51
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2023
VL 20
IS 8
BP 3417
EP 3434
DI 10.1111/iwj.14196
EA APR 2023
PG 18
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S0FS0
UT WOS:000972984400001
PM 37095726
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Fukuda, T
   Reddy, V
   Ptaszek, AJ
AF Fukuda, Tomiko
   Reddy, Verrabdhadra
   Ptaszek, Amy Jo
TI The Infected Calcaneus
SO FOOT AND ANKLE CLINICS
LA English
DT Article
DE Infection; Calcaneus; Angiosomes
ID VACUUM-ASSISTED CLOSURE; HEALING RISK-FACTORS; INTERNAL-FIXATION; OPEN
   REDUCTION; FRACTURES; OSTEOMYELITIS; COMPLICATIONS
AB Infections of the calcaneus can be extremely challenging to resolve. A thorough clinical examination with close follow-up is critical for any patients at risk for developing wound complications. In the diabetic population, education and prevention are essential for minimizing the frequency and severity of calcaneal infections. Open reduction and internal fixation improves outcomes in many intraarticular calcaneal fractures, but constant cognition of the condition of the delicate soft-tissue envelope can help to minimize postoperative complications. Minimizing internal fixation in patients with large soft-tissue deficits may at times be the better part of valor. When osteomyelitis is encountered, limb perfusion must be confirmed. In conjunction with thorough debridement, early soft-tissue coverage is necessary in addition to intravenous antibiotics. If limb salvage is to be achieved for some of these more extensive infections, the multidisciplinary approach is important with the buy in and commitment of all contributors, especially patients.
C1 [Fukuda, Tomiko] Fondren Orthopaed Grp LLC, Pearland, TX 77584 USA.
   [Reddy, Verrabdhadra] Austin Orthopaed, Austin, TX 78745 USA.
   [Ptaszek, Amy Jo] Univ Chicago, Dept Orthopaed Surg, Chicago, IL 60637 USA.
   [Ptaszek, Amy Jo] Illinois Bone & Joint Inst LTD, Glenview, IL 60025 USA.
C3 University of Chicago
RP Ptaszek, AJ (通讯作者)，Illinois Bone & Joint, 2401 Ravine Way, Glenview, IL 60025 USA.
EM amytoe@hotmail.com
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NR 35
TC 22
Z9 29
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1083-7515
EI 1558-1934
J9 FOOT ANKLE CLIN
JI Foot Ankle Clin.
PD SEP
PY 2010
VL 15
IS 3
BP 477
EP 486
DI 10.1016/j.fcl.2010.04.002
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 746EE
UT WOS:000289224700006
PM 20682417
DA 2026-07-24
ER

PT J
AU Alikhan, A
   Sayed, C
   Alavi, A
   Alhusayen, R
   Brassard, A
   Burkhart, C
   Crowell, K
   Eisen, DB
   Gottlieb, AB
   Hamzavi, I
   Hazen, PG
   Jaleel, T
   Kimball, AB
   Kirby, J
   Lowes, MA
   Micheletti, R
   Miller, A
   Naik, HB
   Orgill, D
   Poulin, Y
AF Alikhan, Ali
   Sayed, Christopher
   Alavi, Afsaneh
   Alhusayen, Raed
   Brassard, Alain
   Burkhart, Craig
   Crowell, Karen
   Eisen, Daniel B.
   Gottlieb, Alice B.
   Hamzavi, Iltefat
   Hazen, Paul G.
   Jaleel, Tara
   Kimball, Alexa B.
   Kirby, Joslyn
   Lowes, Michelle A.
   Micheletti, Robert
   Miller, Angela
   Naik, Haley B.
   Orgill, Dennis
   Poulin, Yves
TI North American clinical management guidelines for hidradenitis
   suppurativa: A publication from the United States and Canadian
   Hidradenitis Suppurativa Foundations Part I: Diagnosis, evaluation, and
   the use of complementary and procedural management
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE acne inversa; adalimumab; biomarkers; carbon dioxide laser; clindamycin;
   comorbidities; ertapenem; finasteride; guidelines; hidradenitis
   suppurativa; infliximab; laser; lifestyle modification; microbiome;
   Nd:YAG; oral contraceptive pills; rifampin; spironolactone
ID NEGATIVE-PRESSURE DRESSINGS; COMPLICATING NEVUS COMEDONICUS;
   VACUUM-ASSISTED CLOSURE; CHRONIC PAIN MANAGEMENT; DIOXIDE LASER
   EXCISION; QUALITY-OF-LIFE; SURGICAL-TREATMENT; PHOTODYNAMIC THERAPY;
   ACNE-INVERSA; AMINOLEVULINIC ACID
AB Hidradenitis suppurativa is a chronic inflammatory disorder affecting hair follicles, with profoundly negative impact on patient quality of life. Evidence informing ideal evaluation and management of patients with hidradenitis suppurativa is still sparse in many areas, but it has grown substantially in the last decade. Part I of this evidence-based guideline is presented to support health care practitioners as they select optimal management strategies, including diagnostic testing, comorbidity screening, and both complementary and procedural treatment options. Recommendations and evidence grading based on the evidence available at the time of the review are provided.
C1 [Alikhan, Ali] Sutter Hlth, Sacramento, CA USA.
   [Sayed, Christopher; Burkhart, Craig] Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27515 USA.
   [Alavi, Afsaneh; Alhusayen, Raed] Univ Toronto, Div Dermatol, Dept Med, Toronto, ON, Canada.
   [Brassard, Alain; Eisen, Daniel B.] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA.
   [Crowell, Karen] Univ N Carolina, Sch Med, Hlth Sci Lib, Chapel Hill, NC 27515 USA.
   [Gottlieb, Alice B.] Mt Sinai Hosp, Dept Dermatol, Icahn Sch Med, New York, NY 10029 USA.
   [Hamzavi, Iltefat; Miller, Angela] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA.
   [Hazen, Paul G.] Associates Dermatol, Westlake, OH USA.
   [Jaleel, Tara] Duke Univ, Sch Med, Durham, NC USA.
   [Kimball, Alexa B.] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA.
   [Kirby, Joslyn] Penn State Hershey Med Ctr, Dept Dermatol, Hershey, PA USA.
   [Lowes, Michelle A.] Lab Invest Dermatol, New York, NY USA.
   [Micheletti, Robert] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Micheletti, Robert] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA.
   [Naik, Haley B.] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA.
   [Orgill, Dennis] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Poulin, Yves] Ctr Rech Dermatol Quebec Metropolitain, Quebec City, PQ, Canada.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of Toronto; University of California System; University of
   California Davis; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   Icahn School of Medicine at Mount Sinai; Henry Ford Health System; Henry
   Ford Hospital; Duke University; Harvard University; Harvard Medical
   School; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; University of
   Pennsylvania; University of Pennsylvania; University of California
   System; University of California San Francisco; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital
RP Sayed, C (通讯作者)，Univ North Carolina Dermatol, 410 Market St,Suite 400, Chapel Hill, NC 27516 USA.
EM christopher_sayed@med.unc.edu
RI Eisen, Daniel/AAG-9323-2019; Sayed, Christopher/AAC-3343-2020; Lowes,
   Michelle A/G-9585-2016; Hamzavi, Iltefat/AAW-7320-2021; Orgill,
   Dennis/H-7596-2019
OI Eisen, Daniel/0000-0001-6741-3182; Sayed,
   Christopher/0000-0003-3201-4637; Lowes, Michelle A/0000-0003-4256-478X;
   Kimball, Alexana/0000-0001-9405-0479; 
FU National Center for Advancing Translational Sciences [KL2TR001870]
   Funding Source: NIH RePORTER; NIAMS NIH HHS [K23 AR074531] Funding
   Source: Medline
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NR 213
TC 234
Z9 277
U1 1
U2 22
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD JUL
PY 2019
VL 81
IS 1
BP 76
EP 90
DI 10.1016/j.jaad.2019.02.067
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IE1WF
UT WOS:000472175800017
PM 30872156
OA Green Submitted
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Huang, Q
   Li, JS
   Lau, WY
AF Huang, Qian
   Li, Jieshou
   Lau, Wan-yee
TI Techniques for Abdominal Wall Closure after Damage Control Laparotomy:
   From Temporary Abdominal Closure to Early/Delayed Fascial Closure-A
   Review
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID NEGATIVE-PRESSURE THERAPY; ACELLULAR DERMAL MATRIX; ASSISTED WOUND
   CLOSURE; AORTIC-ANEURYSM REPAIR; OPEN ABDOMEN TREATMENT; VENTRAL HERNIA
   REPAIR; VACUUM PACK TECHNIQUE; COMPARTMENT SYNDROME; ABSORBABLE MESH;
   BOGOTA BAG
AB Open abdomen (OA) has been an effective treatment for abdominal catastrophes in traumatic and general surgery. However, management of patients with OA remains a formidable task for surgeons. The central goal of OA is closure of fascial defect as early as is clinically feasible without precipitating abdominal compartment syndrome. Historically, techniques such as packing, mesh, and vacuum-assisted closure have been developed to assist temporary abdominal closure, and techniques such as components separation, mesh-mediated traction, bridging fascial defect with permanent synthetic mesh, or biologic mesh have also been attempted to achieve early primary fascial closure, either alone or in combined use. The objective of this review is to present the challenges of these techniques for OA with a goal of early primary fascial closure, when the patient's physiological condition allows.
C1 [Huang, Qian; Li, Jieshou; Lau, Wan-yee] Nanjing Univ, Res Inst Gen Surg, Jinling Hosp, Sch Med, Nanjing 210000, Jiangsu, Peoples R China.
   [Lau, Wan-yee] Chinese Univ Hong Kong, Fac Med, Shatin, Hong Kong, Peoples R China.
C3 Nanjing University; Chinese University of Hong Kong
RP Li, JS (通讯作者)，Nanjing Univ, Res Inst Gen Surg, Jinling Hosp, Sch Med, Nanjing 210000, Jiangsu, Peoples R China.
EM lijieshou1924@sina.com
FU National Science Foundation of China [81370514]
FX This work was supported by the National Science Foundation of China
   (Grant 81370514).
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NR 98
TC 56
Z9 65
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2016
VL 2016
AR 2073260
DI 10.1155/2016/2073260
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DB2GT
UT WOS:000368327000001
PM 26819597
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Carlesimo, B
   Lo Torto, F
   Rossi, A
   Marcasciano, M
   Ruggiero, M
AF Carlesimo, B.
   Lo Torto, F.
   Rossi, A.
   Marcasciano, M.
   Ruggiero, M.
TI Long-term result of bilateral pectoralis major muscle advancement flap
   in median sternotomy wound infections
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Sternal infection; Sternal osteomyelitis; Pectoralis major muscle flap
ID DEEP STERNAL INFECTIONS; VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY;
   CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS; ANTIBIOTIC IRRIGATION;
   RECONSTRUCTION; TRANSPOSITION; MANAGEMENT; OMENTUM
AB OBJECTIVE: Deep sternal wound infection (DSWI) is an uncommon but serious complication of open heart surgery being characterized by a high mortality rate and a considerable economic weight. Repair of sternal defects, compromised with infection, can be achieved in several ways. The aim of our study is to report our case load in the management of sternal wound infection.
   PATIENTS AND METHODS: In this study, we will report our twelve-year case load with bilateral pectoralis major advancement flap as the sole treatment modality for deep sternal wound infection.
   RESULTS: This surgical approach has given excellent results in terms of resolution of the infection of the sternum, with few complications and a good cosmetic result.
   CONCLUSIONS: We propose bilateral pectoralis major advancement flap as the first choice treatment for deep sternal wound infection.
C1 [Carlesimo, B.; Lo Torto, F.; Rossi, A.; Marcasciano, M.; Ruggiero, M.] Univ Roma La Sapienza, Dept Plast & Reconstruct & Aesthet Surg, I-00185 Rome, Italy.
C3 Sapienza University Rome
RP Lo Torto, F (通讯作者)，Univ Roma La Sapienza, Dept Plast & Reconstruct & Aesthet Surg, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM federicolotorto@gmail.com
RI Torto, Federico/AAY-1852-2021; Marcasciano, Marco/HZJ-0259-2023
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NR 43
TC 10
Z9 11
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2014
VL 18
IS 24
BP 3767
EP 3772
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CF0CS
UT WOS:000352210900009
PM 25555865
DA 2026-07-24
ER

PT J
AU Sijan, G
   Vojvodic, A
   Milicevic, S
   Vucetic, D
   Petrov, N
   Kozarski, J
   Dordevic, B
   Ostojic, N
   Nikolic, Z
   Mitric, B
   Malivukovic, A
   Stepic, N
AF Sijan, Goran
   Vojvodic, Aleksandra
   Milicevic, Sasa
   Vucetic, Dusan
   Petrov, Nenad
   Kozarski, Jefta
   Dordevic, Boban
   Ostojic, Nikola
   Nikolic, Zivan
   Mitric, Biljana
   Malivukovic, Ana
   Stepic, Nenad
TI Platelet gel in wound treatment in patient with pemphigus vulgaris and
   Type 2 diabetes mellitus: Case report
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE pemphigus vulgaris; platelet gel; Type 2 diabetes mellitus; wound
   healing
ID RICH PLASMA
AB Treatment of wounds, especially in patients with systemic diseases, is very difficult and time consuming, and it represents great challenge. Complications like infections and impaired healing are regularly seen in these patients, sometimes leaving almost no other treating option, but amputation surgery. In wound healing process, platelets play one of key roles, both in hemostasis, and, by releasing many growth factors, in reepithelization and tissue remodeling. Platelet concentrates are defined as autologous or homologous platelet derivatives with a platelet concentration higher than it is usually in human blood. Concentration of platelets needed to affect wound healing should be 1,000,000/mu l. This is a report about patient with pemphigus vulgaris and Type 2 diabetes mellitus, who got injury of the left lower leg. Traditional surgical methods of wound closure and vacuum-assisted closure therapy were ineffective. Homologous platelet gel was used topically, resulting in wound closure, without any adverse effects.
C1 [Sijan, Goran; Milicevic, Sasa; Kozarski, Jefta; Dordevic, Boban; Ostojic, Nikola; Nikolic, Zivan; Mitric, Biljana; Stepic, Nenad] Univ Def, Clin Plast Surg & Burns, Med Fac, Mil Med Acad, Belgrade, Serbia.
   [Vojvodic, Aleksandra] Mil Med Acad, Clin Dermatol & Venereol, Belgrade, Serbia.
   [Vucetic, Dusan] Univ Def, Mil Med Acad, Inst Transfuziol, Med Fac, Belgrade, Serbia.
   [Petrov, Nenad] Univ Def, Mil Med Acad, Inst Pathol & Forens Med, Med Fac, Belgrade, Serbia.
   [Malivukovic, Ana] Gen Hosp Una, Belgrade, Serbia.
C3 Ministry of Defense - Republic of Serbia; University of Defense -
   Republic of Serbia; Ministry of Defense - Republic of Serbia; University
   of Defense - Republic of Serbia; Ministry of Defense - Republic of
   Serbia; University of Defense - Republic of Serbia; Ministry of Defense
   - Republic of Serbia; University of Defense - Republic of Serbia
RP Sijan, G (通讯作者)，Univ Def, Clin Plast Surg & Burns, Med Fac, Mil Med Acad, Belgrade, Serbia.
EM goran.sijan64@gmail.com
RI /AAY-9325-2020; Djordjevic, Boban/AAX-3849-2020
OI Milićević, Saša/0009-0003-0134-2598; 
CR [Anonymous], IMPLANT DENT
   Barrientos S, 2008, WOUND REPAIR REGEN, V16, P585, DOI 10.1111/j.1524-475X.2008.00410.x
   Carter MJ, 2011, EPLASTY, V11, P382
   Cohn CS, 2015, CURR OPIN HEMATOL, V22, P527, DOI 10.1097/MOH.0000000000000183
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   Hantash BM, 2008, FRONT BIOSCI-LANDMRK, V13, P51, DOI 10.2741/2559
   Li JLY, 2017, J EXP MED, V214, P2193, DOI 10.1084/jem.20170879
   Picard F, 2015, WOUND REPAIR REGEN, V23, P163, DOI 10.1111/wrr.12266
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   Semenic D, 2018, ACTA CLIN CROAT, V57, P434, DOI 10.20471/acc.2018.57.03.05
NR 11
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD NOV-DEC
PY 2019
VL 32
IS 6
AR e13099
DI 10.1111/dth.13099
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KM7YD
UT WOS:000514355300024
PM 31579989
DA 2026-07-24
ER

PT J
AU Angoules, AG
   Kontakis, G
   Drakoulakis, E
   Vrentzos, G
   Granick, MS
   Giannoudis, PV
AF Angoules, A. G.
   Kontakis, G.
   Drakoulakis, E.
   Vrentzos, G.
   Granick, M. S.
   Giannoudis, P. V.
TI Necrotising fasciitis of upper and lower limb: A systematic review
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE necrotising fasciitis; limb; surgical management; review
ID SOFT-TISSUE INFECTIONS; VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN
   THERAPY; CLINICAL PRESENTATION; UPPER EXTREMITY; MORTALITY; MANAGEMENT;
   MICROBIOLOGY; SEPSIS
AB Necrotising fasciitis is a rapidly progressive, life threatening soft tissue infection. In a significant proportion of patients, the extremities are involved as a result of trauma, needle puncture or extravasation of drugs, often leading to limb toss and devastating disability. In this systematic review of necrotising fasciitis of the upper and lower extremities, we report on the clinical characteristics, the predisposing factors, the associated diseases, the pathogenic bacteria, the surgical treatment and the final outcome in terms of limb loss and mortality. Data for a total of 451 patients were analysed for each parameter of interest. A percentage of 22.3% of the reviewed patients underwent amputation or disarticulation of a limb following failure of multiple debridements to control infection and the mortality rate was estimated as high as 21.9%. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Angoules, A. G.; Drakoulakis, E.; Giannoudis, P. V.] Univ Leeds, Sch Med, Acad Dept Trauma & Orthopaed Surg, Leeds, W Yorkshire, England.
   [Kontakis, G.] Univ Crete, Sch Med, Acad Dept Trauma & Orthopaed Surg, Iraklion, Greece.
   [Vrentzos, G.] Hlth Ctr Kasteliou, Crete, France.
   [Granick, M. S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA.
C3 University of Leeds; University of Crete; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences
RP Giannoudis, PV (通讯作者)，Gen Infirm, Acad Dept Trauma & Orthopaed, Great George St, Leeds LS1 3EX, W Yorkshire, England.
RI Angoules, Antonios/G-4579-2017; Giannoudis, Peter/AAA-3617-2020
OI Angoules, Antonios/0000-0002-7118-958X; 
CR Anaya D.A, 2005, ARCH SURG-CHICAGO, V140, P8
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NR 49
TC 136
Z9 158
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2007
VL 38
SU 5
BP S19
EP S26
DI 10.1016/j.injury.2007.10.030
PG 8
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 258FZ
UT WOS:000252855100004
PM 18048033
DA 2026-07-24
ER

PT J
AU Furr, J
   Culkin, D
AF Furr, James
   Culkin, Daniel
TI Injury to the male external genitalia: a comprehensive review
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Trauma; External genitalia; Skin flaps; Male genital injury
ID VACUUM-ASSISTED CLOSURE; FOURNIERS GANGRENE; PENILE FRACTURE; GUNSHOT
   WOUNDS; MANAGEMENT; RECONSTRUCTION; EXPERIENCE; SCROTUM; FLAP; DIAGNOSIS
AB While rare, trauma and injury to the male external genitalia can result in significant consequences regarding function, appearance, psychological effects, and overall quality of life. Due to the relative paucity of literature regarding male external genitalia injuries, few standardized protocols exist. This review aims to outline common clinical causes of male external genitalia injuries by both anatomic location and etiology. Initial stabilization, long-term reconstruction, and coverage options are discussed in detail. Outcomes of complex grafts have favorable success rates of 90-100% in the hands of experienced surgeons. Outcomes of penile, testicular trauma also have favorable outcomes when managed appropriately. Attempts at reconstruction after initial injury stabilization should be undertaken at high-volume centers where a multidisciplinary approach can be employed. This manuscript will be an excellent reference and source that can provide direction for evaluation and management of these complex presentations.
C1 [Furr, James; Culkin, Daniel] Univ Oklahoma, Hlth Sci Ctr, Dept Urol, Oklahoma City, OK 73106 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP Culkin, D (通讯作者)，Univ Oklahoma, Hlth Sci Ctr, Dept Urol, Oklahoma City, OK 73106 USA.
EM Daniel-Culkin@ouhsc.edu
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NR 69
TC 20
Z9 23
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD APR
PY 2017
VL 49
IS 4
BP 553
EP 561
DI 10.1007/s11255-017-1526-x
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ER0HV
UT WOS:000398469800001
PM 28181114
DA 2026-07-24
ER

PT J
AU Younan, GJ
   Heit, YI
   Dastouri, P
   Kekhia, H
   Xing, W
   Gurish, MF
   Orgill, DP
AF Younan, George J.
   Heit, Yvonne I.
   Dastouri, Pouya
   Kekhia, Hussein
   Xing, Wei
   Gurish, Michael F.
   Orgill, Dennis P.
TI Mast Cells Are Required in the Proliferation and Remodeling Phases of
   Microdeformational Wound Therapy
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; IMMUNE CELLS; INFLAMMATION; MATRIX; TISSUE;
   INVOLVEMENT; CHYMASE; DEVICE
AB Background: Mast cells are important in numerous inflammatory processes. They are also mechanosensitive and likely play an important role in wound healing. The authors hypothesized that mechanical alteration of the wound environment with a distributed suction device could link mast cells to the healing cascade.
   Methods: Controlled uniform full-thickness wound surface microdeformations were induced by suction combined with an open-pore polyurethane foam (microdeformational wound therapy) in mast cell-deficient WWv mice and their mast cell-sufficient littermates. Wound healing parameters were assessed in the inflammatory, proliferative, and remodeling phases of healing.
   Results: Wound tissue granulation, cell proliferation, blood vessel sprouting, and collagen maturation were found to be mast cell-dependent throughout the proliferating and remodeling stages of healing.
   Conclusion: Mast cells are critical in the robust granulation tissue response seen in microdeformational wound therapy and in the modulation of the remodeling phase of wound healing. (Plast. Reconstr. Surg. 128: 649e, 2011.)
C1 [Orgill, Dennis P.] Harvard Univ, Div Plast Surg, Brigham & Womens Hosp, Dept Radiol,Med Sch, Boston, MA 02115 USA.
   Harvard Univ, Dept Med, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy,Med Sch, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Orgill, DP (通讯作者)，Harvard Univ, Div Plast Surg, Brigham & Womens Hosp, Dept Radiol,Med Sch, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI ; Orgill, Dennis/H-7596-2019
OI Younan, George/0000-0001-8502-4850; Orgill, Dennis/0000-0002-8279-7310
FU KCI; National Institutes of Health [GM 052585]
FX Dr. Orgill is the principal investigator on research grants to the
   Brigham and Women's Hospital by, and is also an expert witness for,
   Kinetic Concepts, Inc., San Antonio, Texas. This study was not funded by
   KCI. Dr. Gurish has received research support from National Institutes
   of Health grant GM 052585. The other authors have no financial interests
   to declare.
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NR 38
TC 54
Z9 62
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2011
VL 128
IS 6
BP 649E
EP 658E
DI 10.1097/PRS.0b013e318230c55d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 852DU
UT WOS:000297329700012
PM 22094766
DA 2026-07-24
ER

PT J
AU Sermoneta, D
   Di Mugno, M
   Spada, PL
   Lodoli, C
   Carvelli, ME
   Magalini, SC
   Cavicchioni, C
   Bocci, MG
   Martorelli, F
   Brizi, MG
   Gui, D
AF Sermoneta, D.
   Di Mugno, M.
   Spada, P. L.
   Lodoli, C.
   Carvelli, M. E.
   Magalini, S. C.
   Cavicchioni, C.
   Bocci, M. G.
   Martorelli, F.
   Brizi, M. G.
   Gui, D.
TI Intra-abdominal vacuum-assisted closure (VAC) after necrosectomy for
   acute necrotising pancreatitis: preliminary experience
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal infection; Acute pancreatitis; Laparostomy; Negative pressure;
   VAC
ID TEMPORARY ABDOMINAL CLOSURE; SURGICAL-TREATMENT; 7-YEAR EXPERIENCE; PACK
   TECHNIQUE; WOUND CONTROL; NECROSIS
AB Infection of pancreatic necrosis, although present in less than 10% of acute pancreatitis, carries a high risk of mortality; debridment and drainage of necrosis is the treatment of choice, followed by 'open' or 'close' abdomen management. We recently introduced the use of intra-abdominal vacuum sealing after a classic necrosectomy and laparostomy. Two patients admitted to ICU for respiratory insufficiency and a diagnosis of severe acute pancreatitis developed pancreatic necrosis and were treated by necrosectomy, lesser sac marsupialisation and posterior lumbotomic opening. Both of the patients recovered from pancreatitis and a good healing of laparostomic wounds was obtained with the use of the VAC system. Most relevant advantages of this technique seem to be: the prevention of abdominal compartment syndrome, the simplified nursing of patients and the reduction of time to definitive abdominal closure.
C1 [Sermoneta, D.; Di Mugno, M.; Spada, P. L.; Lodoli, C.; Carvelli, M. E.; Magalini, S. C.; Cavicchioni, C.; Gui, D.] Univ Cattolica Sacro Cuore, Emergency Surg Unit, Dept Surg, Policlin Gemelli, I-00168 Rome, Italy.
   [Bocci, M. G.; Martorelli, F.] Univ Cattolica Sacro Cuore, Intens Care Unit, Dept Anesthesiol, Policlin Gemelli, I-00168 Rome, Italy.
   [Brizi, M. G.] Univ Cattolica Sacro Cuore, Dept Radiol, Policlin Gemelli, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Sermoneta, D (通讯作者)，Univ Cattolica Sacro Cuore, Emergency Surg Unit, Dept Surg, Policlin Gemelli, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM daniel.s@tiscali.it
RI Martorelli, Federica/HKE-6474-2023; Bocci, Maria Grazia/AAL-1170-2020
OI Martorelli, Federica/0000-0002-9690-2548; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 21
TC 11
Z9 17
U1 0
U2 5
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2010
VL 7
IS 6
BP 525
EP 530
DI 10.1111/j.1742-481X.2010.00727.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NW
UT WOS:000287514500014
PM 20726923
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Turza, KC
   Campbell, CA
   Rosenberger, LH
   Politano, AD
   Davies, SW
   Riccio, LM
   Sawyer, RG
AF Turza, Kristin C.
   Campbell, Chris A.
   Rosenberger, Laura H.
   Politano, Amani D.
   Davies, Stephen W.
   Riccio, Lin M.
   Sawyer, Robert G.
TI Options for Closure of the Infected Abdomen
SO SURGICAL INFECTIONS
LA English
DT Review
ID TEMPORARY ABDOMINAL CLOSURE; ACELLULAR DERMAL MATRIX; PLANNED MULTIPLE
   LAPAROTOMIES; POLYPROPYLENE MESH CLOSURE; INCISIONAL HERNIA REPAIR;
   COMPARTMENT SYNDROME; VENTRAL HERNIA; DAMAGE-CONTROL; FASCIAL CLOSURE;
   WITTMANN PATCH
AB Background: The infected abdomen poses substantial challenges to surgeons, and often, both temporary and definitive closure techniques are required. We reviewed the options available to close the abdominal wall defect encountered frequently during and after the management of complicated intra-abdominal infections.
   Methods: A comprehensive review was performed of the techniques and literature on abdominal closure in the setting of intra-abdominal infection.
   Results: Temporary abdominal closure options include the Wittmann Patch, Bogota bag, vacuum-assisted closure (VAC), the AbThera (TM) device, and synthetic or biologic mesh. Definitive reconstruction has been described with mesh, components separation, and autologous tissue transfer.
   Conclusion: Reconstructing the infected abdomen, both temporarily and definitively, can be accomplished with various techniques, each of which is associated with unique advantages and disadvantages. Appropriate judgment is required to optimize surgical outcomes in these complex cases.
C1 [Turza, Kristin C.; Rosenberger, Laura H.; Politano, Amani D.; Davies, Stephen W.; Riccio, Lin M.; Sawyer, Robert G.] Univ Virginia Hlth Syst, Dept Surg, Charlottesville, VA 22908 USA.
   [Campbell, Chris A.] Univ Virginia Hlth Syst, Dept Plast & Reconstruct Surg, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Turza, KC (通讯作者)，Univ Virginia Hlth Syst, Dept Surg, POB 800679, Charlottesville, VA 22908 USA.
EM kt4p@virginia.edu
RI Sawyer, Robert/JXW-6900-2024
OI Sawyer, Robert/0000-0002-8155-2661; Rosenberger,
   Laura/0000-0002-6829-6747
FU NIAID NIH HHS [T32 AI078875] Funding Source: Medline
CR American Society of Colon and Rectal Surgeons, STOM SIT PROC
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NR 65
TC 16
Z9 20
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC
PY 2012
VL 13
IS 6
BP 343
EP 351
DI 10.1089/sur.2012.014
PG 9
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 061GF
UT WOS:000312835800001
PM 23216525
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Widgerow, AD
AF Widgerow, Alan D.
TI Bioengineered Matrices-Part 2: Focal Adhesion, Integrins, and the
   Fibroblast Effect
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE bioengineered skin; integrins; focal adhesions; dermal scaffold
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR-MATRIX; RECEPTOR EXPRESSION;
   MECHANICAL STRETCH; CHRONIC WOUNDS; COLLAGEN GELS; SKIN; BINDING;
   TISSUE; PROLIFERATION
AB Initial efforts at biologic skin replacement strategies were mainly directed toward keratinocyte regeneration and epithelial replacement. It soon became evident that without a good dermal scaffold, the long-term efficacy of epithelial replacement was very limited. Further studies have focused on matrix replacement predominantly involving collagen frameworks with or without cellular additions. The fibroblast is central to the process of dermal regeneration and to the success of biologic matrix design. The sequence of cellular focal adhesion, integrin phosphorylated activation, intracellular and extracellular signaling, cytoskeletal activation, changes in cell morphology, and cytokine growth factor interaction are all important in influencing cell proliferation, cell spreading, neocollagenesis, and collagen translocation. A basic acellular matrix with chemical composition and correct physical structure (pore size and resistance) that takes cognizance of this sequence of matrix deposition and fibroblast functionality should be successful in promoting intrinsic healing and dermal replacement.
C1 [Widgerow, Alan D.] Adar Sci Inc, Irvine, CA 92614 USA.
   [Widgerow, Alan D.] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa.
C3 University of Witwatersrand
RP Widgerow, AD (通讯作者)，Adar Sci Inc, 9 Waterway, Irvine, CA 92614 USA.
EM awidgerow@adarscience.com
RI Widgerow, Alan/AAD-3883-2022
OI Widgerow, Alan/0000-0002-5705-8073
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NR 54
TC 6
Z9 8
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2012
VL 68
IS 6
BP 574
EP 578
DI 10.1097/SAP.0b013e31824b3d1c
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 949RA
UT WOS:000304592300008
PM 22643102
DA 2026-07-24
ER

PT J
AU Young, MH
   Engleberg, NC
   Mulla, ZD
   Aronoff, DM
AF Young, MH
   Engleberg, NC
   Mulla, ZD
   Aronoff, DM
TI Therapies for necrotising fasciitis
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE antimicrobial therapy; bacterial toxins; clindamycin; gangrene;
   intravenous immunoglobulins; necrotising fasciitis; soft tissue
   infection; Streptococcus pyogenes; superantigens; toxic shock syndrome
ID SOFT-TISSUE INFECTIONS; GROUP-A STREPTOCOCCUS; TOXIC-SHOCK-SYNDROME;
   RESISTANT STAPHYLOCOCCUS-AUREUS; HYPERBARIC-OXYGEN THERAPY;
   VACUUM-ASSISTED CLOSURE; HUMAN-LEUKOCYTE ANTIGEN; INTRAVENOUS
   IMMUNOGLOBULIN; RISK-FACTORS; PYROGENIC EXOTOXIN
AB Necrotising fasciitis is a rare but life-threatening infectious disease emergency. Delays in diagnosis and treatment are common, and mortality rates often exceed 30%. Successful management of this disease requires high clinical suspicion and aggressive action. The mainstays of therapy include early and wide surgical debridement, antibiotics and supportive care, with prompt surgical intervention. Adjunctive modalities, such as protein synthesis inhibitors, hyperbaric oxygen and intravenous immunoglobulin, may have a role, but their effectiveness remains unproven. New rapid diagnostic tools are emerging that promise to revolutionise early detection of necrotising fasciitis. Research into the molecular microbiology, especially regarding group A streptococcus, are providing novel insights into the pathogenesis of necrotising soft tissue infections and identifying future targets for rationally designed interventions.
C1 Univ Michigan Hosp, Dept Internal Med, Div Infect Dis, Taubman Ctr 3116, Ann Arbor, MI 48109 USA.
   St Joseph Mercy Hosp, Ypsilanti, MI 48197 USA.
   Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA.
   Univ Michigan Hosp, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA.
   Univ Texas, Sch Publ Hlth Houston, Ctr Infect Dis, Div Epidemiol, El Paso, TX 79902 USA.
   Texas Tech Univ, Hlth Sci Ctr, Dept Obstet & Gynecol, El Paso, TX USA.
C3 University of Michigan System; University of Michigan; Saint Joseph
   Mercy Health System (SJMHS); University of Michigan System; University
   of Michigan; University of Michigan System; University of Michigan;
   University of Texas System; University of Texas El Paso; Texas Tech
   University System; Texas Tech University Health Sciences Center El Paso;
   Texas Tech University
RP Aronoff, DM (通讯作者)，Univ Michigan Hosp, Dept Internal Med, Div Infect Dis, Taubman Ctr 3116, Box 0378, Ann Arbor, MI 48109 USA.
EM youngmh@trinity-health.org; cengleb@umich.edu;
   zuber.d.mulla@uth.tmc.edu; daronoff@umich.edu
OI Aronoff, David/0000-0003-4587-6121
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NR 119
TC 28
Z9 33
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1471-2598
EI 1744-7682
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD FEB
PY 2006
VL 6
IS 2
BP 155
EP 165
DI 10.1517/14712598.6.2.155
PG 11
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 013JO
UT WOS:000235405800007
PM 16436041
DA 2026-07-24
ER

PT J
AU Herold, J
   Notov, D
   Reeps, C
   Schaser, KD
   Kamin, K
   Maeder, M
   Kleber, C
AF Herold, J.
   Notov, D.
   Reeps, C.
   Schaser, K. D.
   Kamin, K.
   Maeder, M.
   Kleber, C.
TI Limb salvage in traumatic hemipelvectomy: case series with surgical
   management and review of the literature
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Review
DE Traumatic hemipelvectomies; Limb salvage; REBOA; Pelvic injuries;
   Quality of life; Long-term outcome
ID ENDOVASCULAR BALLOON OCCLUSION; LIFE-THREATENING HEMORRHAGE;
   VACUUM-ASSISTED CLOSURE; INJURY SEVERITY; AORTA; THERAPY
AB BackgroundTraumatic hemipelvectomies are rare and serious injuries. The surgical management was described in several case studies, with primary amputation often performed to save the patient's life.MethodsWe report of two survivors with complete traumatic hemipelvectomy resulting in ischemia and paralyzed lower extremity. Due to modern emergency medicine and reconstructive surgery, limb salvage could be attained. Long-term outcome with quality of life was assessed one year after the initial accident.Results and conclusionsThe patients were able to mobilize themselves and live an independent life. The extremities remained without function and sensation. Urinary continence and sexual function were present and the colostomy could be relocated in both patients. Both patients support limb salvage, even having difficulties and follow-up treatments. Concomitant cases are required to consolidate the findings.
C1 [Herold, J.; Schaser, K. D.; Kamin, K.; Maeder, M.] Univ Hosp Carl Gustav Carus, Univ Ctr Orthopaed Trauma & Plast Surg, Dresden, Germany.
   [Reeps, C.] Univ Hosp Carl Gustav Carus, Dept Visceral Thorac & Vasc Surg, Dresden, Germany.
   [Notov, D.; Kleber, C.] Univ Hosp Leipzig, Dept Orthoped Trauma & Plast Surg, Liebigstr 20, D-04103 Leipzig, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Leipzig University
RP Herold, J (通讯作者)，Univ Hosp Carl Gustav Carus, Univ Ctr Orthopaed Trauma & Plast Surg, Dresden, Germany.
EM johannes.herold@uniklinikum-dresden.de
OI Herold, Johannes/0000-0003-0529-8072
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. No external
   funding was received for any aspect of this work.
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NR 62
TC 3
Z9 5
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD OCT
PY 2023
VL 143
IS 10
BP 6177
EP 6192
DI 10.1007/s00402-023-04913-y
EA JUN 2023
PG 16
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA R5CC0
UT WOS:001007647000002
PM 37314526
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Schintler, MV
   Prandl, EC
   Wittguber, G
   Zink, B
   Spendal, S
   Hellbom, B
   Scharnagl, E
AF Schintler, MV
   Prandl, EC
   Wittguber, G
   Zink, B
   Spendal, S
   Hellbom, B
   Scharnagl, E
TI The impact of the VAC-treatment for locally advanced malignancy of the
   scalp
SO ZENTRALBLATT FUR CHIRURGIE
LA English
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE cutaneous malignancy; scalp reconstruction; VAC((R)) -vacuum; assisted
   closure; geriatric patient; polymorbidity
ID DENUDED CRANIAL BONE; SOFT-TISSUE DEFECTS; ASSISTED CLOSURE; EXPOSED
   BONE; WOUND CONTROL; SKIN-GRAFTS; MANAGEMENT; SURGERY; REPAIR;
   ANESTHESIA
AB Locally advanced cutaneous malignancy of the scalp is a desease that requires an aggressive approach to resection and reconstruction. In cases where the pericranium is intact a split-thickness skin graft is a simple treatment, since direct closure often fails because due to the lack of elasticity of the scalp [11, 36]. If there is a loss of periosteum or a skull defect local or free flaps [27, 29, 44] are necessary for sufficient coverage. Increasing geriatric and polymorbid patients with impaired wound healing [4] require surgical treatment, considering pros and cons for general anaesthesia [7 - 9,13, 16, 45]. A simple method of both, combining radicality of tumorresection with outer table bone and skin grafting as a two stage procedure, while minimizing perioperative risk using local anaesthesia and analgo-sedation, using the vacuum assisted closure device, is presented.
C1 Med Univ Graz, Klin Abt Plast Chirurg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Schintler, MV (通讯作者)，Auenbruggerpl 29, A-8036 Graz, Austria.
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NR 50
TC 6
Z9 11
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S141
EP S146
DI 10.1055/s-2004-822690
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600044
PM 15168314
DA 2026-07-24
ER

PT J
AU Tian, LJ
   Ji, XL
   Chen, T
   Qi, F
   Tian, FR
   Yao, Q
   Tian, F
AF Tian, Lijie
   Ji, Xianglu
   Chen, Ting
   Qi, Feng
   Tian, Furong
   Yao, Qiang
   Tian, Feng
TI Deep hypothermic preservation of autologous skin in the treatment of
   large-area circumferential multi-plane degloving trauma: a pilot study
   of 2 cases
SO CELL AND TISSUE BANKING
LA English
DT Article
DE Deep hypothermic preservation; Autologous skin; Large-area degloving
   trauma
ID VACUUM-ASSISTED CLOSURE; CRYOPRESERVED SKIN; INJURIES
AB To evaluate the clinical outcome of deep hypothermic preservation of autologous skin in the treatment of large-area skin avulsion. Medium or full thickness-skin slices were harvested from large avulsion flaps between July and November 2017. They were stored in liquid nitrogen by vitrification. After the patient's condition became stable and the growth of the wound granulation tissue was satisfactory, the frozen skin slices were reheated quickly and replanted to the wound. Autologous skin that had been kept by deep cryopreservation had a high survival rate when grafted. It did not create new trauma or bring additional pain to patients. Yet it could shorten the course of treatment and reduce the medical cost for patients. It is an effective and economical way to treat large-area skin avulsion.
C1 [Tian, Lijie; Ji, Xianglu; Chen, Ting; Yao, Qiang; Tian, Feng] China Med Univ, Dept Hand & Foot Surg, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
   [Qi, Feng] Shenwei Hosp Shenyang, Dept Hand & Foot Surg, Shenyang 110000, Liaoning, Peoples R China.
   [Tian, Furong] Shenyang Med Coll, Dept Hand Surg, Cent Hosp, Shenyang 110024, Liaoning, Peoples R China.
C3 China Medical University; Shenyang Medical College
RP Ji, XL (通讯作者)，China Med Univ, Dept Hand & Foot Surg, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
EM jixianglu2018@163.com
RI /P-5856-2014
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NR 13
TC 2
Z9 4
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9333
EI 1573-6814
J9 CELL TISSUE BANK
JI Cell Tissue Banking
PD MAR
PY 2019
VL 20
IS 1
BP 109
EP 115
DI 10.1007/s10561-018-09745-4
PG 7
WC Cell Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA HT8WX
UT WOS:000464846500010
PM 30637555
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Maillard, H
AF Maillard, H.
TI Negative pressure therapy: NPT
SO ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
LA French
DT Article
DE Negative topic pressure; Surgical wound; Chronic wound; Budding
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; ULCERS
AB Negative pressure therapy or treatment (NPT) is used very frequently in hospitals in both surgical and medical departments. NPT consists of maintaining the wound surface at a pressure below ambient atmospheric pressure by means of a specially designed dressing attached to a depressurisation device as well as a system to drain exudate. NPT has been shown to be beneficial in increasing blood flow, thanks to feedback resulting from the decreased oxygen pressure, angiogenesis and reduction of the wound surface area. The French Health Authority (HAS) has issued recommendations for good use in a specific and limited series of applications. NPT may be used in post-traumatic or post-surgical wounds, burns, and in chronic wounds, such as bedsores and ulcers. It is also effective as an adjuvant treatment for infected wounds. In recent years, various different NPT devices have become commercially available. (C) 2015 Elsevier Masson SAS. All rights reserved.
C1 Ctr Hosp Gen, Serv Dermatol, F-72037 Le Mans 9, France.
RP Maillard, H (通讯作者)，Ctr Hosp Gen, Serv Dermatol, 194 Ave Rubillard, F-72037 Le Mans 9, France.
EM hmaillard@ch-lemans.fr
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NR 12
TC 1
Z9 2
U1 0
U2 4
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0151-9638
EI 2214-5451
J9 ANN DERMATOL VENER
JI Ann. Dermatol. Venereol.
PD AUG-SEP
PY 2015
VL 142
IS 8-9
BP 498
EP 501
DI 10.1016/j.annder.2015.06.008
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CT8VS
UT WOS:000363095600006
PM 26249531
DA 2026-07-24
ER

PT J
AU Bertheuil, N
   Aillet, S
   Heusse, JL
   Flecher, E
   Watier, E
AF Bertheuil, N.
   Aillet, S.
   Heusse, J. L.
   Flecher, E.
   Watier, E.
TI Large Necrosis: A Rare Complication of Medial Thighplasty
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Medial thighplasty; Skin necrosis; Bariatric surgery; Obesity
ID THIGH LIFT
AB Obesity is a major public health problem in Western societies. After failure of diet and exercise, patients can have bariatric surgery. Weight loss causes excess skin on the body, including the thighs. This leads to difficulty walking and psychological disorders such as devalued self-image. Medial thighplasty is an intervention to reduce excess skin and fat in the thighs. The main complications are scar migration, scar infection, hematoma, lymphedema, gaping vulva, and, rarely, skin necrosis. We describe a case of flap necrosis after a reoperation of medial thighplasty. Treatment included debridement of necrotic tissue and healing of the wound by secondary intention (vacuum-assisted closure and dressings with calcium alginate). Complete healing was achieved in 4 months. As the patient refused any new procedure, skin grafting was not performed. The aesthetic results of plastic surgery procedures are often imperfect. Patients should be clearly prepared and informed about the results expected from the operation. Surgeons should know contraindications for reoperation.
C1 [Bertheuil, N.; Aillet, S.; Heusse, J. L.; Flecher, E.; Watier, E.] Hosp Sud, Dept Plast Reconstruct & Aesthet Surg, F-35200 Rennes, France.
C3 CHU Rennes
RP Bertheuil, N (通讯作者)，Hosp Sud, Dept Plast Reconstruct & Aesthet Surg, 16 Blvd Bulgarie, F-35200 Rennes, France.
EM nbertheuil@gmail.com
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NR 10
TC 3
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-216X
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD FEB
PY 2012
VL 36
IS 1
BP 88
EP 90
DI 10.1007/s00266-011-9752-6
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 901WY
UT WOS:000301000500014
PM 21607533
DA 2026-07-24
ER

PT J
AU Wang, ZH
   Hu, JL
   Zhao, ZY
   Sun, JJ
   Li, JC
   Qian, XL
   Cheng, ZY
AF Wang, Zhihua
   Hu, Junlong
   Zhao, Zeyuan
   Sun, Junjie
   Li, Jianchao
   Qian, Xiaoliang
   Cheng, Zhaoyun
TI Delayed sternal Mycobacterium tuberculosis infection after left
   ventricular assist device implantation: A case report
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Left ventricular assist device; sternal tuberculosis; Mycobacterium
   tuberculosis; infection
AB The incidence of Mycobacterium tuberculosis (Mtb) infection in patients with mechanical circulatory support devices is extremely rare. We present a case involving a 38-year-old male who experienced a delayed sternal Mtb infection following left ventricular assist device (LVAD) implantation. More than 5 months post-surgery, the patient was readmitted to the hospital presenting a subxiphoid abscess. The incision site displayed an unsatisfactory healing process after the incision and drainage of the abscess. Despite engaging in a rigorous treatment protocol, which included anti-infective therapy, vacuum-assisted closure, and surgical debridement, the patient's wound remained unhealed. Ultimately, after pus gene sequencing confirmed the diagnosis, the patient was administered a regimen combining anti-tuberculosis and anti-infective therapy, which culminated in the successful healing of the wound. This singular case study not only reveals the clinical progression of an unexpected Mtb infection post-implantation but also emphasizes the challenges encountered in diagnosis and management.
C1 [Wang, Zhihua; Hu, Junlong; Zhao, Zeyuan; Sun, Junjie; Cheng, Zhaoyun] Zhengzhou Univ, Cent China Fuwai Hosp, Dept Cardiac Surg, Zhengzhou, Henan, Peoples R China.
   [Li, Jianchao; Qian, Xiaoliang] Zhengzhou Univ, Cent China Fuwai Hosp, Dept Extracorporeal Circulat, Zhengzhou, Henan, Peoples R China.
   [Cheng, Zhaoyun] Zhengzhou Univ, Cent China Fuwai Hosp, Dept Cardiac Surg, 1 Fuwai Rd, Zhengzhou 451464, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University
RP Cheng, ZY (通讯作者)，Zhengzhou Univ, Cent China Fuwai Hosp, Dept Cardiac Surg, 1 Fuwai Rd, Zhengzhou 451464, Henan, Peoples R China.
EM Chengzhy@zzu.edu.cn
RI sun, junjie/HHC-5265-2022; Qian, Xiaoliang/AAV-1480-2020
FU Key Research and Development Special Project of Henan Province
   [221111310300]; Medical Science and Technology Project of Henan Province
   [LHGJ20220111]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Key Research and Development Special Project of
   Henan Province (221111310300) and the Medical Science and Technology
   Project of Henan Province (LHGJ20220111).
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NR 19
TC 2
Z9 2
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD MAR
PY 2024
VL 47
IS 3
BP 217
EP 222
DI 10.1177/03913988241229957
EA FEB 2024
PG 6
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA KT8R3
UT WOS:001163997600001
PM 38362751
DA 2026-07-24
ER

PT J
AU Zhang, Z
   Long, J
   Geng, J
   Xia, WS
AF Zhang, Ziang
   Long, Jie
   Geng, Jian
   Xia, Wensen
TI Efficacy of autologous platelet-rich plasma for long-term
   glucocorticoids caused chronic wound: a case report
SO CELL AND TISSUE BANKING
LA English
DT Article
DE Platelet-rich plasma; Chronic wound; Tissue regeneration; Macrophage
ID INFLAMMATION
AB The repair of bone explore wounds is one of the difficult problems in plastic and reconstruction surgery. Platelet-rich plasma (PRP) is a safe and efficient therapeutic option for various trauma, including Osteoarticular, musculoskeletal, and Wound injuries. However, the preparation and storage of PRP becomes challenging for patients with poor systemic status and requiring multi-use of PRP. The availability of safe, reliable tissue bank makes it possible. We report a case of a 42-year-old woman patient with a chronic hip wound combined with ischium bone exploration. And the patient who was treated with long-term glucocorticoids for rheumatoid arthritis has been through the experience of extensive conservative management. Thereafter necrosectomy and Vacuum-Assisted Closure (VAC) surgical procedure failed, and a PRP daily injection was performed at the ischial muscle and soft tissue. Neo-muscle appeared around the explored ischium bone after 8 weeks of injection and Complete wound healing was obtained in 3 months.
C1 [Zhang, Ziang; Long, Jie; Geng, Jian; Xia, Wensen] Air Force Med Univ, Xijing Hosp, Dept Plast Surg, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University
RP Geng, J; Xia, WS (通讯作者)，Air Force Med Univ, Xijing Hosp, Dept Plast Surg, Xian, Shaanxi, Peoples R China.
EM gengjian144@163.com; 13892804883@139.com
FU National Natural Science Foundation of China [82102355]
FX AcknowledgementsThis work was supported by Grants from the National
   Natural Science Foundation of China under Grant 82102355.
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NR 12
TC 0
Z9 1
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9333
EI 1573-6814
J9 CELL TISSUE BANK
JI Cell Tissue Banking
PD DEC
PY 2023
VL 24
IS 4
BP 705
EP 710
DI 10.1007/s10561-023-10083-3
EA MAR 2023
PG 6
WC Cell Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA X1HV2
UT WOS:000945748200001
PM 36894793
DA 2026-07-24
ER

PT J
AU Hogan, N
   Byrnes, V
   Hussey, A
   Joyce, M
AF Hogan, Niamh
   Byrnes, Valerie
   Hussey, Alan
   Joyce, Myles
TI Surgical management of gluteal metastatic cutaneous Crohn's disease
SO JOURNAL OF CROHNS & COLITIS
LA English
DT Article
DE Metastatic cutaneous Crohn's; Gluteal
ID HIDRADENITIS SUPPURATIVA; INFLIXIMAB; PERINEAL
AB Metastatic cutaneous Crohn's disease is a rare entity first described by McCallum et al. in 1976. It is diagnosed when histologically characteristic granulomata are seen at a site not contiguous with inflammatory disease in the gastrointestinal tract. We herein report presentation, diagnosis and management of a 28 year old lady with disabling, symptomatic cutaneous Crohn's of the buttocks and natal cleft refractory to Infliximab therapy. To the best of our knowledge only four other adult cases have been reported in the literature of metastatic cutaneous Crohn's disease of the buttock area distant from a flexure or area of skin apposition. The differential diagnosis in this case was Hidradenitis Suppurativa. A good cosmetic result and excellent symptom control were achieved with extensive debridement, wide local excision, vacuum assisted closure and delayed skin grafting. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
C1 [Hogan, Niamh; Joyce, Myles] Univ Coll Hosp Galway, Dept Colorectal Surg, Galway, Ireland.
   [Byrnes, Valerie] Univ Coll Hosp Galway, Dept Gastroenterol, Galway, Ireland.
   [Hussey, Alan] Univ Coll Hosp Galway, Dept Plast Surg, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway; Ollscoil na Gaillimhe-University of
   Galway
RP Hogan, N (通讯作者)，Univ Coll Hosp Galway, Dept Colorectal Surg, Galway, Ireland.
EM niamhogan@gmail.com
CR ATTANOOS RL, 1993, HISTOPATHOLOGY, V23, P111, DOI 10.1111/j.1365-2559.1993.tb00468.x
   BERNSTEIN LH, 1980, GASTROENTEROLOGY, V79, P599
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   Emanuel PO, 2008, J CUTAN PATHOL, V35, P457, DOI 10.1111/j.1600-0560.2007.00849.x
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   WILLIAMS N, 1993, BRIT J SURG, V80, P1596, DOI 10.1002/bjs.1800801235
NR 19
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1873-9946
J9 J CROHNS COLITIS
JI J. Crohns Colitis
PD JUN
PY 2012
VL 6
IS 5
BP 617
EP 620
DI 10.1016/j.crohns.2011.12.015
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 950ZF
UT WOS:000304689700017
PM 22398091
OA hybrid
DA 2026-07-24
ER

PT J
AU Reiffel, AJ
   Henderson, PW
   Karwowski, JK
   Spector, JA
AF Reiffel, Alyssa J.
   Henderson, Peter W.
   Karwowski, John K.
   Spector, Jason A.
TI An Interdisciplinary Approach to the Prevention and Treatment of Groin
   Wound Complications After Lower Extremity Revascularization
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID VASCULAR GRAFT INFECTIONS; VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS;
   MANAGEMENT; PRESERVATION; EXPERIENCE; SARTORIUS; COVERAGE; SALVAGE
AB Background: If not effectively treated, groin wound infections following lower extremity revascularization (LER) may result in graft or limb loss.
   Methods: A retrospective review was performed of all patients who underwent muscle flap transposition by a single surgeon after LER between 2006 and 2010.
   Results: Twenty-nine muscle transposition flaps were performed in 24 patients (21 sartorius, 6 rectus femoris, and 2 gracilis). Nineteen were for treatment of groin wound infections, two for treatment of lymphocele, one for coverage of exposed graft in the setting of pyoderma gangrenosum, and seven for infection prophylaxis. Two graft losses followed flap placement. The limb loss rate was 4%. When performed for therapeutic purposes, graft salvage rates were 100% for autogenous and 92% for synthetic grafts.
   Conclusions: Muscle transposition flaps are an effective means of graft salvage in the setting of groin wound complications following LER and should be considered for infection prophylaxis in high-risk patients.
C1 [Reiffel, Alyssa J.; Henderson, Peter W.; Spector, Jason A.] Weill Cornell Med Coll, Div Plast Surg, New York, NY 10065 USA.
   [Karwowski, John K.] Weill Cornell Med Coll, Div Vasc Surg, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine; Cornell University; Weill
   Cornell Medicine
RP Spector, JA (通讯作者)，Weill Cornell Med Coll, Div Plast Surg, Payson 709-A,525 E 68th St, New York, NY 10065 USA.
EM jas2037@med.cornell.edu
RI Henderson, Peter/O-1053-2017
OI Henderson, Peter/0000-0002-8392-7180
CR Alkon JD, 2005, PLAST RECONSTR SURG, V115, P776, DOI 10.1097/01.PRS.0000152436.50604.04
   Armstrong PA, 2007, J VASC SURG, V46, P71, DOI 10.1016/j.jvs.2007.02.058
   CALLIGARO KD, 1992, ANN SURG, V216, P74, DOI 10.1097/00000658-199207000-00011
   CALLIGARO KD, 1994, ANN SURG, V220, P461, DOI 10.1097/00000658-199410000-00005
   CARTER SC, 1963, ANN SURG, V158, P249, DOI 10.1097/00000658-196308000-00014
   Colwell AS, 2004, ANN PLAS SURG, V52, P49, DOI 10.1097/01.sap.0000099960.68038.53
   Dosluoglu HH, 2010, J VASC SURG, V51, P1160, DOI 10.1016/j.jvs.2009.11.053
   Dosluoglu HH, 2005, J VASC SURG, V42, P989, DOI 10.1016/j.jvs.2005.07.006
   Gardetto A, 2005, BRIT J PLAST SURG, V58, P175, DOI 10.1016/j.bjps.2004.08.001
   Graham RG, 2002, PLAST RECONSTR SURG, V109, P108, DOI 10.1097/00006534-200201000-00018
   Herrera FA, 2009, AM SURGEON, V75, P877
   Illig KA, 2004, ANN VASC SURG, V18, P661, DOI 10.1007/s10016-004-0105-7
   Sbitany H, 2009, 26 ANN M NE SOC PLAS, V1, P160
   Seify H, 2006, PLAST RECONSTR SURG, V117, P1325, DOI 10.1097/01.prs.0000204961.32022.ab
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
NR 15
TC 7
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD APR
PY 2012
VL 26
IS 3
BP 365
EP 372
DI 10.1016/j.avsg.2011.08.002
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 913BZ
UT WOS:000301847700010
PM 22055159
DA 2026-07-24
ER

PT J
AU Ashton, R
   Moledina, J
   Sivakumar, B
   Mellerio, JE
   Martinez, AE
AF Ashton, Rosalind
   Moledina, Jamil
   Sivakumar, Branavan
   Mellerio, Jemima E.
   Martinez, Anna E.
TI Considerations in surgical management of a Buschke-Lowenstein tumor in
   Netherton syndrome: A case report
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
DE ichthyosis; Netherton syndrome; pediatric dermatology; topical negative
   pressure therapy; vacuum assisted closure device
AB Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenstein tumor of the natal cleft in a patient with Netherton syndrome that had failed to respond to medical management. We reviewed the literature for previous cases of surgery in individuals with Netherton syndrome using MEDLINE and PubMed searches. Our patient underwent surgery to remove the lesion without complication. Using conventional dressings and topical negative-pressure therapy, the wound was managed and healed within a reasonable time frame despite the underlying skin condition. This case indicates that surgery and topical negative-pressure therapy is a safe and reasonable treatment for individuals with Netherton syndrome.
C1 [Ashton, Rosalind] Univ Ottawa, Div Plast Surg, Ottawa, ON, Canada.
   [Moledina, Jamil] St George Hosp, Dept Plast Surg, London, England.
   [Sivakumar, Branavan] Great Ormond St Hosp Sick Children, Dept Plast Surg, London, England.
   [Mellerio, Jemima E.; Martinez, Anna E.] Great Ormond St Hosp Sick Children, Dept Dermatol, London, England.
C3 University of Ottawa; City St Georges, University of London; University
   of London; University College London; Great Ormond Street Hospital for
   Children NHS Foundation Trust; University of London; University College
   London; Great Ormond Street Hospital for Children NHS Foundation Trust
RP Martinez, AE (通讯作者)，Great Ormond St Hosp Sick Children, Dept Dermatol, London, England.
EM anna.martinez@gosh.nhs.uk
RI ; Mellerio, Jemima/G-3681-2012
OI Ashton, Rosalind/0000-0002-5672-6594; Mellerio,
   Jemima/0000-0002-2670-8117
CR Benzon H, 2012, PEDIATR ANESTH, V22, P410, DOI 10.1111/j.1460-9592.2012.03815.x
   Di WL, 2011, HARPERS TXB PEDIAT D
   Li ALK, 2011, J PLAST RECONSTR AES, V64, P1533, DOI 10.1016/j.bjps.2011.03.013
   Wirsching KEC, 2013, BMC EAR NOSE THROAT, V13, DOI 10.1186/1472-6815-13-7
NR 4
TC 10
Z9 10
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD NOV-DEC
PY 2017
VL 34
IS 6
BP E328
EP E330
DI 10.1111/pde.13292
PG 3
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA FM8PG
UT WOS:000415350800010
PM 29144034
DA 2026-07-24
ER

PT J
AU Parise, AC
   Mateo, G
   Sierra, MD
   Benso, JD
   Funtes, NA
   Villena, DS
   Cafruni, VM
   Carrasco, NM
   Araujo, MGS
AF Parise, Ana C.
   Mateo, Gonzalo
   Sierra, Mariana de Paz
   Benso, Jose D.
   Funtes, Nora A.
   Villena, Daniel S.
   Cafruni, Virginia M.
   Carrasco, Nelly M.
   Araujo, Maria G. Santini
TI Osteomyelitis in diabetic foot: reconstruction with autologous bone
   graft
SO MEDICINA-BUENOS AIRES
LA Spanish
DT Article
DE diabetic foot; polymethylmethacrylate cement spacer; limb salvage;
   osteomyelitis; metatarsophalangeal arthrodesis
ID METATARSOPHALANGEAL JOINT; ARTHRODESIS; OUTCOMES; SALVAGE; SPACER
AB Moderate to severe infections in the diabetic foot (DF), such as osteomyelitis, frequently require surgical intervention and prolonged antibiotic therapy. Amputation is often unavoidable, with high morbidity and mortality rates in the initial years. Bone resection can lead to deformities and loss of foot function, introducing further complications. This report presents a case of a 45-year-old patient with type 2 Diabetes Mellitus (DM) and osteomyelitis in the first ray, managed through surgical debridement, an antibiotic-loaded cement spacer, and vacuum-assisted closure (VAC) to control infection, along with a six-week antibiotic treatment. Following favorable clinical progress and normalization of inflammatory markers, a second-stage surgical reconstruction was performed using autologous bone grafting and metatarsophalangeal arthrodesis with internal fixation to preserve the length and functionality of the first ray. The patient demonstrated positive outcomes over the next 40 months, with no recurrence of infection.
C1 [Parise, Ana C.; Sierra, Mariana de Paz; Benso, Jose D.; Villena, Daniel S.; Cafruni, Virginia M.; Carrasco, Nelly M.; Araujo, Maria G. Santini] Hosp Italiano Buenos Aires, Tte Gral Juan D Peron 4190, RA-1199 Mar Del Plata, Buenos Aires, Argentina.
   [Mateo, Gonzalo; Funtes, Nora A.] Hosp Privado Comun, Mar del Plata, Buenos Aires, Argentina.
C3 Hospital Italiano de Buenos Aires
RP Parise, AC (通讯作者)，Hosp Italiano Buenos Aires, Tte Gral Juan D Peron 4190, RA-1199 Mar Del Plata, Buenos Aires, Argentina.
EM ana.parise@hospitalitaliano.org.ar
RI Araújo, Maria/ACG-5919-2022
CR Berardinelli EM, 2021, ACTA BIOQUIM CLIN L, V55, P61
   Carro GV, 2023, MEDICINA-BUENOS AIRE, V83, P428
   Dalla Paola L, 2015, J FOOT ANKLE SURG, V54, P536, DOI 10.1053/j.jfas.2014.08.004
   Elmarsafi T, 2017, INT J SURG CASE REP, V41, P174, DOI 10.1016/j.ijscr.2017.08.066
   Elmarsafi T, 2017, J FOOT ANKLE SURG, V56, P287, DOI 10.1053/j.jfas.2016.10.022
   Joseph Thomas N, 2003, J Am Acad Orthop Surg, V11, P38
   Kastrin M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10061208
   Malhotra K, 2015, FOOT ANKLE INT, V36, P556, DOI 10.1177/1071100714563536
   Mateo G, 2022, AAOT-TL
   Mavrogenis AF, 2018, EFORT OPEN REV, V3, P513, DOI 10.1302/2058-5241.3.180010
   Melamed EA, 2012, FOOT ANKLE INT, V33, P213, DOI 10.3113/FAI.2012.0213
   Myerson MS, 2000, FOOT ANKLE INT, V21, P297, DOI 10.1177/107110070002100405
   Piaggesi A, 2017, The Diabetic Foot Syndrome, V1st
   Roukis TS, 2004, J AM PODIAT MED ASSN, V94, P492, DOI 10.7547/0940492
NR 14
TC 0
Z9 0
U1 0
U2 0
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
EI 1669-9106
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PD MAY-JUN
PY 2025
VL 85
IS 3
BP 601
EP 605
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4RH1A
UT WOS:001524789300013
PM 40577147
DA 2026-07-24
ER

PT J
AU Deniz, H
   Arslanoglu, Y
   Ari, M
AF Deniz, Hayati
   Arslanoglu, Yavuz
   Ari, Murat
TI Better outcomes with a new type of pressure wound therapy for
   mediastinitis after cardiac surgery
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Mediastinit; VAC therapy; Wound
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE MEDIASTINITIS; MANAGEMENT
AB Background: The aim of the present study is to compare the clinical outcomes and survival in our 40 patients underwent NPWT with or without instillation treatment for mediastinitis after cardiac surgery. Materials end Methods: In this study, we retrospectively compared the clinical outcome and survival in 40 patients undergoing VAC therapy with or without instillation treatment for DSWI after cardiac surgery. Only patients with mediastinitis those are consisting of sternum and presternal tissue infection after coronary bypass surgery were included in the present study. Results: Mean age of patients was 58.86 +/- 11.6 and 57 patients of them were female and 33 of them were male. Primary surgery among the 40 patients presenting with DSWI; was coronary artery bypass revascularization. Conclusion: The use of VAC therapy with instillation has changed the management of complicated infected or colonized wounds and has become the standard of care our facility.
C1 [Deniz, Hayati; Arslanoglu, Yavuz; Ari, Murat] Gaziantep Ersin Arslan Educ & Res Hosp, Dept Cardiovasc Surg, Gaziantep, Turkey.
RP Deniz, H (通讯作者)，Fatih Mah 22 Nolu Sok Cankaya Sitesi C Blok Daire, Gaziantep, Turkey.
EM hayatideniz@gmail.com
RI ARSLANOGLU, YAVUZ/JLK-8285-2023; ARI, Murat/MIU-3719-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   De Feo M, 2001, ANN THORAC SURG, V71, P324, DOI 10.1016/S0003-4975(00)02137-8
   Douville EC, 2004, ANN THORAC SURG, V78, P1659, DOI 10.1016/j.athoracsur.2004.04.082
   Drosou A, 2003, WOUNDS, V15, P149
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
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   Sjögren J, 2004, J HEART LUNG TRANSPL, V23, P506, DOI 10.1016/S1053-2498(03)00224-9
NR 12
TC 0
Z9 0
U1 1
U2 2
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD DEC
PY 2020
VL 22
IS 4
AR e2020090
DI 10.23751/pn.v22i4.10930
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PR5NF
UT WOS:000607282500015
DA 2026-07-24
ER

PT J
AU Eichhorn, ME
   Winter, H
   Preissler, G
   Hatz, R
   Lindner, M
AF Eichhorn, M. E.
   Winter, H.
   Preissler, G.
   Hatz, R.
   Lindner, M.
TI Modern Tailored Therapy for Pleural Empyema
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Review
DE infection; thoracoscopy; thoracotomy; pleural empyema
ID VACUUM-ASSISTED CLOSURE; COMPLICATED PARAPNEUMONIC EFFUSIONS;
   INTRAPLEURAL STREPTOKINASE; THORACOSCOPIC SURGERY; SURGICAL-TREATMENT;
   THORACIC EMPYEMA; MANAGEMENT; INFECTION; EXPERIENCE
AB In spite of the development and widespread availability of modern antibiotics, pleural empyema still represents a serious intrathoracic disease associated with significant morbidity and mortality. Patients with complicated parapneumonic effusions and empyema have an increased morbidity and mortality due at least in part to inappropriate and delayed management of pleural space infections. Timely diagnosis of pleural empyema and rapid initiation of the appropriate surgical treatment modality represent keystone principles for efficient treatment of thoracic empyema. Simple drainage, minimally invasive surgical treatment modalities (VATS) and image-guided small-bore catheters in combination with adjunctive fibrinolytic drugs have extended the potential therapeutic arsenal. Individual case management with a flexible selection of the most appropriate treatment modality by experienced thoracic surgeons may lead to improved outcomes. In this context a summary of the most recent opinions and results in thoracic empyema management is outlined in the present review.
C1 [Eichhorn, M. E.; Winter, H.; Preissler, G.; Hatz, R.] Univ Munich, Chirurg Klin & Poliklin Grosshadern, Thoraxchirurg Zentrum Munchen, D-81371 Munich, Germany.
   [Hatz, R.; Lindner, M.] Asklepios Fachkliniken Munchen Gauting, Thoraxchirurg Zentrum Munchen, Gauting, Germany.
C3 University of Munich
RP Eichhorn, ME (通讯作者)，Univ Munich, Chirurg Klin & Poliklin Grosshadern, Thoraxchirurg Zentrum Munchen, Marchioninistr 15, D-81371 Munich, Germany.
EM martin.eichhorn@med.uni-muenchen.de
RI Lindner, Michael/AAO-8653-2020; Eichhorn, Martin/GRE-9126-2022; Winter,
   Hauke/I-1394-2013
OI Lindner, Michael/0000-0002-2106-0286; Eichhorn,
   Martin/0000-0002-0362-0374; Winter, Hauke/0009-0007-5242-6942
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NR 40
TC 1
Z9 2
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD FEB
PY 2011
VL 136
IS 1
BP 34
EP 41
DI 10.1055/s-0030-1262539
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 742DA
UT WOS:000288918400010
PM 21337291
DA 2026-07-24
ER

PT J
AU Richards, AJ
   Hagelstein, SM
   Patel, GK
   Ivins, NM
   Sweetland, HM
   Harding, KG
AF Richards, Alastair J.
   Hagelstein, Sue M.
   Patel, Girish K.
   Ivins, Nicola M.
   Sweetland, Helen M.
   Harding, Keith G.
TI Early use of negative pressure therapy in combination with silver
   dressings in a difficult breast abscess
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Breast abscess; Silver dressings; Topical antiseptic; Topical negative
   pressure therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; EFFICACY
AB Combining silver-based dressings with negative pressure therapy after radical excision of chronically infected breast disease is a novel application of two technologies. One patient with complex, chronic, infected breast disease underwent radical excision of the affected area and was treated early with a combination of silver-based dressings and topical negative pressure therapy. The wound was then assessed sequentially using clinical measurements of wound area and depth, pain severity scores and level of exudation. It is possible to combine accepted techniques with modern dressing technologies that result in a positive outcome. In this case, the combination of a silver-based dressing with negative pressure therapy following radical excision proved safe and was well tolerated by the patient. Full epithelisation of the wound was achieved and there was no recurrence of the infection for the duration of the treatment.
C1 [Richards, Alastair J.; Hagelstein, Sue M.; Patel, Girish K.; Ivins, Nicola M.; Sweetland, Helen M.; Harding, Keith G.] Cardiff Univ, Sch Med, Dept Dermatol & Wound Healing, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Richards, AJ (通讯作者)，Cardiff Univ, Sch Med, Dept Dermatol & Wound Healing, Heath Pk, Cardiff CF14 4XN, S Glam, Wales.
EM richardsaj1@cardiff.ac.uk
RI Patel, Girish/N-7075-2013; Harding, Keith/J-5605-2013
OI Harding, Keith/0000-0003-0048-3279
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NR 22
TC 13
Z9 15
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2011
VL 8
IS 6
BP 608
EP 611
DI 10.1111/j.1742-481X.2011.00838.x
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 854AL
UT WOS:000297466800007
PM 21883932
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Rivera, AE
   Spencer, JM
AF Rivera, Albert E.
   Spencer, James M.
TI Clinical aspects of full-thickness wound healing
SO CLINICS IN DERMATOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; OCCLUSIVE DRESSINGS; TISSUE ADHESIVE; CALCIUM
   ALGINATE; RANDOMIZED-TRIAL; ABSORBABLE SUTURE; CADEXOMER IODINE; SKIN;
   GROWTH; MANAGEMENT
AB Optimal management of full-thickness wounds requires a thorough knowledge of wound-healing principles and practices. In the absence of underlying disease, almost every full-thickness wound will heal with minimal intervention; however, the process can be enhanced by judicious wound management. The first clinical decision to be made is whether to repair the wound or to allow it to heal by second intention. This decision is guided by a host of objective and subjective factors. Reconstruction options include primary closure, flaps, and grafts. Materials to aid reconstruction, including the introduction of tissue adhesives, continue to evolve. Both primary and secondary intention wounds are aided by occlusive dressings and adjutants. A plethora of wound-healing adjuncts have been developed to aid wound healing in diseased states, and a working knowledge of their use is beneficial in. managing all full-thickness wounds. (C) 2007 Elsevier Inc. All rights reserved.
C1 Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Spencer, JM (通讯作者)，Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA.
EM jgspencer@tampabay.rr.com
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NR 146
TC 92
Z9 116
U1 1
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JAN-FEB
PY 2007
VL 25
IS 1
BP 39
EP 48
DI 10.1016/j.clindermatol.2006.10.001
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 143EJ
UT WOS:000244702500007
PM 17276200
DA 2026-07-24
ER

PT J
AU Somanchi, BV
   Khan, S
AF Somanchi, Brinda Vihari
   Khan, Sohail
TI Vacuum-assisted wound closure (VAC) with simultaneous bone transport in
   the leg: A technical note
SO ACTA ORTHOPAEDICA BELGICA
LA English
DT Article
DE long bone fracture; non-union; bone transport; vacuum assisted wound
   closure
ID SOFT-TISSUE INJURIES; THERAPY; FRACTURES; RECONSTRUCTION; EXTREMITIES;
   MANAGEMENT; TRAUMA
AB Successful treatment of infected non union in long bone fractures has always been a challenge. Segmental excision followed by bone transport is one of the common modalities of treatment in such difficult cases. The soft tissue coverage of the resulting wounds was however not well described in the literature. The authors would like to report a simple technique that was used. After segmental bone excision and application of a ring fixator, a vacuum assisted closure (VAC) dressing was applied to the wound, which resulted in not only a remarkable growth of granulation tissue that filled the soft tissue defect, but also satisfactory signs of bony union across the docking site.
   The authors would like to emphasise the benefits of a simple method such as VAC therapy in enhancing cover of the large soft tissue defects during simultaneous bone transportation, and thus avoiding complex plastic surgical procedures.
C1 [Somanchi, Brinda Vihari; Khan, Sohail] Salford Royal Hosp, Salford, Lancs, England.
C3 Salford Royal NHS Foundation Trust; Salford Royal Hospital
RP Somanchi, BV (通讯作者)，3 Squires Court, Salford M5 5AD, Lancs, England.
EM brindavihari2001@yahoo.com
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NR 20
TC 2
Z9 2
U1 0
U2 0
PU ACTA MEDICA BELGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138-A, B-1180 BRUSSELS, BELGIUM
SN 0001-6462
J9 ACTA ORTHOP BELG
JI Acta Orthop. Belg.
PD AUG
PY 2008
VL 74
IS 4
BP 538
EP 541
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 344IS
UT WOS:000258920700019
PM 18811041
DA 2026-07-24
ER

PT J
AU Norman, G
   Shi, CH
   Goh, EL
   Murphy, EMA
   Reid, A
   Chiverton, L
   Stankiewicz, M
   Dumville, JC
AF Norman, Gill
   Shi, Chunhu
   Goh, En Lin
   Murphy, Elizabeth M. A.
   Reid, Adam
   Chiverton, Laura
   Stankiewicz, Monica
   Dumville, Jo C.
TI Negative pressure wound therapy for surgical wounds healing by primary
   closure
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Bandages; Blister [epidemiology]; Hematoma [epidemiology];
   Negative-Pressure Wound Therapy [economics] [instrumentation] [*methods]
   [mortality]; Orthopedic Procedures; Quality Adjusted Life Years;
   Randomized Controlled Trials as Topic; Reoperation [statistics &
   numerical data]; Seroma [epidemiology]; *Skin Transplantation; Surgical
   Procedures, Operative [mortality]; Surgical Wound Dehiscence
   [epidemiology] [*prevention & control]; Surgical Wound Infection
   [epidemiology] [*prevention & control]; *Wound Healing; Wounds and
   Injuries [surgery]; Humans
ID VACUUM-ASSISTED-CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SEVERE OPEN
   FRACTURES; SITE INFECTION; LOWER-LIMB; COST-EFFECTIVENESS;
   CLINICAL-EFFICACY; TISSUE EXPANSION; SUCTION DRAINAGE; CESAREAN-SECTION
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.
   Objectives
   To assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.
   Search methods
   In January 2021, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.
   Selection criteria
   We included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another.
   Data collection and analysis
   At least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane risk of bias tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology. Our primary outcomes were SSI, mortality, and wound dehiscence.
   Main results
   In this fourth update, we added 18 new randomised controlled trials (RCTs) and one new economic study, resulting in a total of 62 RCTs (13,340 included participants) and six economic studies. Studies evaluated NPWT in a wide range of surgeries, including orthopaedic, obstetric, vascular and general procedures. All studies compared NPWT with standard dressings. Most studies had unclear or high risk of bias for at least one key domain.
   Primary outcomes
   Eleven studies (6384 participants) which reported mortality were pooled. There is low-certainty evidence showing there may be a reduced risk of death after surgery for people treated with NPWT (0.84%) compared with standard dressings (1.17%) but there is uncertainty around this as confidence intervals include risk of benefits and harm; risk ratio (RR) 0.78 (95% CI 0.47 to 1.30;I-2 = 0%). Fifty-four studies reported SSI; 44 studies (11,403 participants) were pooled. There is moderate-certainty evidence that NPWT probably results in fewer SSIs (8.7% of participants) than treatment with standard dressings (11.75%) after surgery; RR 0.73 (95% CI 0.63 to 0.85;I-2 = 29%). Thirty studies reported wound dehiscence; 23 studies (8724 participants) were pooled. There is moderate-certainty evidence that there is probably little or no difference in dehiscence between people treated with NPWT (6.62%) and those treated with standard dressing (6.97%), although there is imprecision around the estimate that includes risk of benefit and harms; RR 0.97 (95% CI 0.82 to 1.16;I-2 = 4%). Evidence was downgraded for imprecision, risk of bias, or a combination of these.
   Secondary outcomes
   There is low-certainty evidence for the outcomes of reoperation and seroma; in each case, confidence intervals included both benefit and harm. There may be a reduced risk of reoperation favouring the standard dressing arm, but this was imprecise: RR 1.13 (95% CI 0.91 to 1.41;I-2 = 2%; 18 trials; 6272 participants). There may be a reduced risk of seroma for people treated with NPWT but this is imprecise: the RR was 0.82 (95% CI 0.65 to 1.05;I-2 = 0%; 15 trials; 5436 participants). For skin blisters, there is low-certainty evidence that people treated with NPWT may be more likely to develop skin blisters compared with those treated with standard dressing (RR 3.55; 95% CI 1.43 to 8.77; I-2 = 74%; 11 trials; 5015 participants). The effect of NPWT on haematoma is uncertain (RR 0.79; 95 % CI 0.48 to 1.30;I-2 = 0%; 17 trials; 5909 participants; very low-certainty evidence). There is low-certainty evidence of little to no difference in reported pain between groups. Pain was measured in different ways and most studies could not be pooled; this GRADE assessment is based on all fourteen trials reporting pain; the pooled RR for the proportion of participants who experienced pain was 1.52 (95% CI 0.20,11.31; I-2 = 34%; two studies; 632 participants).
   Cost-effectiveness
   Six economic studies, based wholly or partially on trials in our review, assessed the cost-effectiveness of NPWT compared with standard care. They considered NPWT in five indications: caesarean sections in obese women; surgery for lower limb fracture; knee/hip arthroplasty; coronary artery bypass grafts; and vascular surgery with inguinal incisions. They calculated quality-adjusted life-years or an equivalent, and produced estimates of the treatments' relative cost-effectiveness. The reporting quality was good but the evidence certainty varied from moderate to very low. There is moderate-certainty evidence that NPWT in surgery for lower limb fracture was not cost-effective at any threshold of willingness-to-pay and that NPWT is probably cost-effective in obese women undergoing caesarean section. Other studies found low or very low-certainty evidence indicating that NPWT may be cost-effective for the indications assessed.
   Authors' conclusions
   People with primary closure of their surgical wound and treated prophylactically with NPWT following surgery probably experience fewer SSIs than people treated with standard dressings but there is probably no difference in wound dehiscence (moderate-certainty evidence). There may be a reduced risk of death after surgery for people treated with NPWT compared with standard dressings but there is uncertainty around this as confidence intervals include risk of benefit and harm (low-certainty evidence). People treated with NPWT may experience more instances of skin blistering compared with standard dressing treatment (low-certainty evidence). There are no clear differences in other secondary outcomes where most evidence is low or very low-certainty. Assessments of cost-effectiveness of NPWT produced differing results in different indications. There is a large number of ongoing studies, the results of which may change the findings of this review. Decisions about use of NPWT should take into account surgical indication and setting and consider evidence for all outcomes.
C1 [Norman, Gill; Shi, Chunhu; Dumville, Jo C.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Goh, En Lin] Nuffield Dept Orthopaed Rheumatol & Musculoskelet, 0Xford Trauma, Oxford, England.
   [Murphy, Elizabeth M. A.] Manchester Fdn NHS Trust, Ward 64, St Marys Hosp, Manchester, Lancs, England.
   [Reid, Adam] Fac Biol Med & Hlth, Sch Biol Sci, Manchester, Lancs, England.
   [Chiverton, Laura] Great Ormond St Hosp Sick Children, NIHR Clin Res Facil, London, England.
   [Stankiewicz, Monica] Community & Oral Hlth Directorate, Chermside Community Hlth Ctr, Brisbane, Qld, Australia.
C3 University of Manchester; University of Manchester; University of
   Manchester; University of London; University College London; Great
   Ormond Street Hospital for Children NHS Foundation Trust
RP Norman, G (通讯作者)，Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
EM gill.norman@manchester.ac.uk
RI ; Norman, Gill/O-7029-2014; Goh, En/I-7020-2019; Reid, Adam/G-4460-2014;
   Dumville, Jo/O-7867-2014
OI Shi, Chunhu/0000-0003-0151-0451; Stankiewicz,
   Monica/0000-0003-3970-071X; Reid, Adam/0000-0003-1752-3302; Dumville,
   Jo/0000-0002-6546-3685
FU Division of Nursing, Midwifery and Social Work, School of Health
   Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK; Royal Brisbane and Women's Hospital, Australia; GriGith
   University, Australia; NIHR Manchester Biomedical Research Centre, UK;
   NIHR Manchester Biomedical Research Centre; National Institute for
   Health Research Applied Research Collaboration Greater Manchester, UK;
   National Institute for Health Research Applied Research Collaboration
   Greater Manchester; National Institute for Health Research, UK; National
   Institute for Health Research
FX Internal sourcesDivision of Nursing, Midwifery and Social Work, School
   of Health Sciences, Faculty of Biology, Medicine and Health, University
   of Manchester, UKSupport from Cochrane Wounds editorial baseRoyal
   Brisbane and Women's Hospital, AustraliaTime to conduct reviewGriGith
   University, AustraliaTime to conduct reviewExternal sourcesNIHR
   Manchester Biomedical Research Centre, UKThis review was co-funded by
   the NIHR Manchester Biomedical Research Centre. The views expressed in
   this publication are those of the author(s) and not necessarily those of
   the NHS, the National Institute for Health Research or the Department of
   Health and Social Care.National Institute for Health Research Applied
   Research Collaboration Greater Manchester, UKSeveral of the authors are
   partially funded by the National Institute for Health Research Applied
   Research Collaboration Greater Manchester. The views expressed in this
   publication are those of the authors and not necessarily those of the
   National Institute for Health. Research or the Department of Health and
   Social Care.National Institute for Health Research, UKThis project was
   supported by the National Institute for Health Research, via Cochrane
   Infrastructure funding to Cochrane Wounds. The views expressed are those
   of the authors and not necessarily those of the NIHR or the Department
   of Health and Social Care.
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NR 266
TC 110
Z9 140
U1 3
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2022
IS 4
AR CD009261
DI 10.1002/14651858.CD009261.pub7
PG 274
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0X9FO
UT WOS:000790005300020
PM 35471497
OA Green Published, Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Norman, G
   Goh, EL
   Dumville, JC
   Shi, CH
   Liu, ZM
   Chiverton, L
   Stankiewicz, M
   Reid, A
AF Norman, Gill
   Goh, En Lin
   Dumville, Jo C.
   Shi, Chunhu
   Liu, Zhenmi
   Chiverton, Laura
   Stankiewicz, Monica
   Reid, Adam
TI Negative pressure wound therapy for surgical wounds healing by primary
   closure
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
DE Bandages; Blister [epidemiology]; Hematoma [epidemiology];
   Negative-Pressure Wound Therapy [economics] [instrumentation] [*methods]
   [mortality]; Orthopedic Procedures; Quality-Adjusted Life Years;
   Randomized Controlled Trials as Topic; Reoperation [statistics &
   numerical data]; Seroma [epidemiology]; *Skin Transplantation; Surgical
   Procedures, Operative [mortality]; Surgical Wound Dehiscence
   [epidemiology] [*prevention & control]; Surgical Wound Infection
   [epidemiology] [*prevention & control]; *Wound Healing; Wounds and
   Injuries [surgery]; Humans
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; COST-EFFECTIVENESS;
   CLINICAL-EFFICACY; TISSUE EXPANSION; RANDOMIZED-TRIAL; CARDIAC-SURGERY;
   CLOSED SUCTION; PRIMARY HIP; LOWER-LIMB
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.
   Objectives
   To assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.
   Search methods
   In June 2019, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.
   Selection criteria
   We included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another type of NPWT.
   Data collection and analysis
   At least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane 'Risk of bias' tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology.
   Main results
   In this third update, we added 15 new randomised controlled trials (RCTs) and three new economic studies, resulting in a total of 44 RCTs (7447 included participants) and five economic studies. Studies evaluated NPWT in the context of a wide range of surgeries including orthopaedic, obstetric, vascular and general procedures. Economic studies assessed NPWT in orthopaedic, obstetric and general surgical settings. All studies compared NPWT with standard dressings. Most studies had unclear or high risk of bias for at least one key domain.
   Primary outcomes
   Four studies (2107 participants) reported mortality. There is low-certainty evidence (downgraded twice for imprecision) showing no clear difference in the risk of death after surgery for people treated with NPWT (2.3%) compared with standard dressings (2.7%) (risk ratio (RR) 0.86; 95% confidence interval (CI) 0.50 to 1.47; I-2 = 0%). Thirty-nine studies reported SSI; 31 of these (6204 participants), were included in meta-analysis. There is moderate-certainty evidence (downgraded once for risk of bias) that NPWT probably results in fewer SSI (8.8% of participants) than treatment with standard dressings (13.0% of participants) after surgery; RR 0.66 (95% CI 0.55 to 0.80; I-2 = 23%). Eighteen studies reported dehiscence; 14 of these (3809 participants) were included in meta-analysis. There is low-certainty evidence (downgraded once for risk of bias and once for imprecision) showing no clear difference in the risk of dehiscence after surgery for NPWT (5.3% of participants) compared with standard dressings (6.2% of participants) (RR 0.88, 95% CI 0.69 to 1.13; I-2 = 0%).
   Secondary outcomes
   There is low-certainty evidence showing no clear difference between NPWT and standard treatment for the outcomes of reoperation and incidence of seroma. For reoperation, the RR was 1.04 (95% CI 0.78 to 1.41; I-2 = 13%; 12 trials; 3523 participants); for seroma, the RR was 0.72 (95% CI 0.50 to 1.05; I-2 = 0%; seven trials; 729 participants). The effect of NPWT on occurrence of haematoma or skin blisters is uncertain (very low-certainty evidence); for haematoma, the RR was 0.67 (95% CI 0.28 to 1.59; I-2 = 0%; nine trials; 1202 participants) and for blisters the RR was 2.64 (95% CI 0.65 to 10.68; I-2 = 69%; seven trials; 796 participants). The overall effect of NPWT on pain is uncertain (very low-certainty evidence from seven trials (2218 participants) which reported disparate measures of pain); but moderate-certainty evidence suggests there is probably little difference between the groups in pain after three or six months following surgery for lower limb fracture (one trial, 1549 participants). There is also moderate-certainty evidence for women undergoing caesarean sections (one trial, 876 participants) and people having surgery for lower limb fractures (one trial, 1549 participants) that there is probably little difference in quality of life scores at 30 days or 3 or 6 months, respectively.
   Cost-effectiveness
   Five economic studies, based wholly or partially on trials included in our review, assessed the cost-effectiveness of NPWT compared with standard care. They considered NPWT in four indications: caesarean sections in obese women; surgery for lower limb fracture; knee/hip arthroplasty and coronary artery bypass graft surgery. They calculated quality-adjusted life-years for treatment groups and produced estimates of the treatments' relative cost-effectiveness. The reporting quality was good but the grade of the evidence varied from moderate to very low. There is moderate-certainty evidence that NPWT in surgery for lower limb fracture was not cost-effective at any threshold of willingness-to-pay and that NPWT is probably cost-effective in obese women undergoing caesarean section. Other studies found low or very low-certainty evidence indicating that NPWT may be cost-effective for the indications assessed.
   Authors' conclusions
   People experiencing primary wound closure of their surgical wound and treated prophylactically with NPWT following surgery probably experience fewer SSI than people treated with standard dressings (moderate-certainty evidence). There is no clear difference in number of deaths or wound dehiscence between people treated with NPWT and standard dressings (low-certainty evidence). There are also no clear differences in secondary outcomes where all evidence was low or very low-certainty. In caesarean section in obese women and surgery for lower limb fracture, there is probably little difference in quality of life scores (moderate-certainty evidence). Most evidence on pain is very low-certainty, but there is probably no difference in pain between NPWT and standard dressings after surgery for lower limb fracture (moderate-certainty evidence). Assessments of cost-effectiveness of NPWT produced differing results in different indications. There is a large number of ongoing studies, the results of which may change the findings of this review. Decisions about use of NPWT should take into account surgical indication and setting and consider evidence for all outcomes.
C1 [Norman, Gill; Dumville, Jo C.; Shi, Chunhu] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Goh, En Lin] Oxford Trauma, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Liu, Zhenmi] Sichuan Univ, West China Sch Publ Hlth, Chengdu, Peoples R China.
   [Liu, Zhenmi] Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China.
   [Chiverton, Laura] Great Ormond St Hosp Sick Children, NIHR Clin Res Facil, London, England.
   [Stankiewicz, Monica] Community & Oral Hlth Directorate, Chermside Community Hlth Ctr, Brisbane, Qld, Australia.
   [Reid, Adam] Fac Biol Med & Hlth, Sch Biol Sci, Manchester, Lancs, England.
C3 University of Manchester; Sichuan University; Sichuan University;
   University of London; University College London; Great Ormond Street
   Hospital for Children NHS Foundation Trust; University of Manchester
RP Norman, G (通讯作者)，Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
EM gill.norman@manchester.ac.uk
RI Norman, Gill/O-7029-2014; Dumville, Jo/O-7867-2014; Reid,
   Adam/G-4460-2014; Liu, Zhenmi/O-7046-2014; Goh, En/I-7020-2019
FU National Institute for Health Research (NIHR), UK; National Institute
   for Health Research, via Cochrane Infrastructure; Cochrane Programme
   Grant funding (NIHR Cochrane Programme) [13/89/08]; National Institute
   for Health Research (NIHR) Systematic Review Fellowships, UK
   [NIHR-RMFI-2015-06-52]; National Institute for Health Research
   Collaboration for Leadership in Applied Health Research and Care (NIHR
   CLAHRC) Greater Manchester Centre, UK; National Institute for Health
   Research Collaboration for Leadership in Applied Health Research and
   Care (NIHR CLAHRC) Greater Manchester; NIHR Manchester Biomedical
   Research Centre, UK; NIHR Manchester Biomedical Research Centre;
   National Institute for Health Research [13/89/08] Funding Source:
   researchfish
FX External sourcesThe National Institute for Health Research (NIHR),
   UKThis project was supported by the National Institute for Health
   Research, via Cochrane Infrastructure and Cochrane Programme Grant
   funding (NIHR Cochrane Programme Grant 13/89/08 - High Priority Cochrane
   Reviews in Wound Prevention and Treatment) to Cochrane Wounds. The views
   expressed are those of the authors and not necessarily those of the NIHR
   or the Department of Health and Social Care.National Institute for
   Health Research (NIHR) Systematic Review Fellowships
   (NIHR-RMFI-2015-06-52 Zhenmi Liu), UKNational Institute for Health
   Research Collaboration for Leadership in Applied Health Research and
   Care (NIHR CLAHRC) Greater Manchester Centre, UKJo Dumville was partly
   funded by the National Institute for Health Research Collaboration for
   Leadership in Applied Health Research and Care (NIHR CLAHRC) Greater
   Manchester. The funder had no role in the design of the studies, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. However, the review may be considered to be affiliated to
   the work of the NIHR CLAHRC Greater Manchester. The views expressed
   herein are those of the authors and not necessarily those of the NHS,
   NIHR or the Department of Health and Social Care.NIHR Manchester
   Biomedical Research Centre, UKThis review was co-funded by the NIHR
   Manchester Biomedical Research Centre. The views expressed in this
   publication are those of the author(s) and not necessarily those of the
   NHS, the National Institute for Health Research or the Department of
   Health and Social Care.
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NR 205
TC 4
Z9 7
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2020
IS 5
AR CD009261
DI 10.1002/14651858.CD009261.pub5
PG 263
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LT4GU
UT WOS:000537031300030
OA Green Published, Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Zhao, JC
   Xian, CJ
   Yu, JA
   Shi, K
AF Zhao, Jing-Chun
   Xian, Chun-Jing
   Yu, Jia-Ao
   Shi, Kai
TI Pedicled full-thickness abdominal flap combined with skin grafting for
   the reconstruction of anterior chest wall defect following major
   electrical burn
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal flap; Chest wall reconstruction; Electrical burn
ID VACUUM-ASSISTED CLOSURE
AB Successful reconstruction of extensive anterior chest wall defect following major electrical burn represents a very challenging surgery. Herein we report the first case using pedicled full-thickness abdominal flap combined with skin grafting to treat this injury with severe infection and exposure of pericardium and ribs in a Chinese patient. Following the performance of chest debridement to remove necrotic and infected tissues and the injection of broad-spectrum antibiotics to reduce infection, a pedicled full-thickness abdominal flap was used to cover the exposed pericardium and ribs, and skin grafting from the right leg of the patient was done to cover the exposed vital tissues. The patient was followed up for a total of 35 years, and satisfactory cosmetic and functional outcomes were obtained without complications. This report provides an effective method for the surgeons who encounter similar cases where reconstruction of extensive anterior chest wall is required.
C1 [Zhao, Jing-Chun; Xian, Chun-Jing; Yu, Jia-Ao; Shi, Kai] Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, Changchun 130031, Peoples R China.
C3 Jilin University
RP Shi, K (通讯作者)，Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Peoples R China.
EM bu_dong007@163.com
CR [Anonymous], WOUNDS
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NR 12
TC 5
Z9 5
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 59
EP 62
DI 10.1111/iwj.12051
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700011
PM 23490336
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Avery, CME
   Pereira, J
   Brown, AE
AF Avery, CME
   Pereira, J
   Brown, AE
TI Suprafascial dissection of the radial forearm flap and donor site
   morbidity
SO INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
DE radial flap; donor site; suprafascial dissection; negative pressure
   wound dressing
ID VACUUM-ASSISTED CLOSURE; FULL-THICKNESS SKIN; CLINICAL-EXPERIENCE; WOUND
   CONTROL; GRAFT
AB A cutaneous free radial forearm flap was harvested from 25 patients using a suprafascial dissection technique. The donor site was managed with either a full or split thickness skin graft and a negative pressure wound dressing. The incidence of initial complete graft take was 96% at day 5 and 100% by 1 month. There was 100% early and complete graft take in the full thickness group but one area of partial loss in the split thickness group. This area of graft loss represented less than 0.5% of the total grafted area in this series. The mean time to wound healing was 14 days. There were no cases of tendon exposure or delayed healing. The suprafascial dissection creates a superior graft recipient bed. When combined with the negative pressure wound dressing technique it ensured early and complete graft take.
C1 Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead RH19 3DZ, W Sussex, England.
   Queen Victoria Hosp, Dept Plast Surg, E Grinstead RH19 3DZ, W Sussex, England.
RP Avery, CME (通讯作者)，Queen Victoria Hosp, Dept Maxillofacial Surg, Holtye Rd, E Grinstead RH19 3DZ, W Sussex, England.
RI /AAI-1364-2019
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NR 20
TC 52
Z9 57
U1 0
U2 1
PU MUNKSGAARD INT PUBL LTD
PI COPENHAGEN
PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK
SN 0901-5027
J9 INT J ORAL MAX SURG
JI Int. J. Oral Maxillofac. Surg.
PD FEB
PY 2001
VL 30
IS 1
BP 37
EP 41
DI 10.1054/ijom.2000.0016
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 406GR
UT WOS:000167207000006
PM 11289619
DA 2026-07-24
ER

PT J
AU Ding, S
   Gong, Y
   Song, MM
   Guo, ZW
   Sun, R
   Liu, YF
   Ge, ZL
AF Ding, Sheng
   Gong, Yin
   Song, Mingming
   Guo, Zaiwen
   Sun, Ran
   Liu, Yunfeng
   Ge, Zili
TI Factors associated with the prognosis of diabetic foot ulcers treated
   with silver ion hydrogel dressings combined with negative pressure wound
   therapy and the construction of a risk prediction model: a study of two
   machine learning methods, LASSO and random forest algorithms
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article; Early Access
DE Diabetic foot ulcer; Silver ion hydrogel; Negative pressure wound
   therapy; Risk prediction model
AB BackgroundDiabetic foot ulcers (DFUs) represent a serious chronic complication of diabetes, with substantial morbidity and healthcare costs. Despite advances in treatment modalities such as silver ion hydrogel dressings combined with negative pressure wound therapy (NPWT), clinical outcomes remain highly heterogeneous. Identifying prognostic factors and developing accurate risk prediction tools are essential for personalized management and improved patient outcomes.<br /> ObjectiveThe objective of this study was to identify key prognostic factors in DFU patients undergoing combined silver ion hydrogel and NPWT therapy and to develop a validated risk prediction model.<br /> MethodsThis retrospective study analyzed 200 DFU patients admitted to our hospital between March 2023 and December 2024. Data were extracted from the electronic medical record system, and patients were stratified into good and poor prognosis groups according to clinical outcomes. After collection and comparison of clinical variables, two machine learning approaches-LASSO regression and random forest (RF)-were employed to identify risk factors using an "overlapping selection" strategy. Significant predictors were further assessed by multivariate logistic analysis. A predictive model was subsequently developed and validated using R software.<br /> ResultsA total of 200 DFU patients were included in the analysis. Based on electronic medical records, 49 patients (24.50%) were classified into the poor prognosis group, while 151 patients (75.50%) comprised the good prognosis group. Significant differences (p < 0.05) were observed between the two groups in several clinical parameters: number of ulcers, ulcer area, interleukin-17 (IL-17) levels, Th1 cell count, Th2 cell count, procalcitonin (PCT), and C-reactive protein (CRP) levels. Using two machine learning methods-LASSO regression and the random forest (RF) algorithm-different sets of risk factors were screened. By applying an "overlap coverage" approach, five common risk factors for DFU prognosis were identified: IL-17, Th1 cells, Th2 cells, PCT, and CRP. These were included in the logistic regression model. The results indicated that IL-17, Th1 cells, PCT, and CRP were all risk factors for poor prognosis in DFU patients (OR = 1.275, 1.411, 1.006, and 1.101, respectively, p < 0.05), while Th2 cells were a protective factor for poor prognosis in DFU patients (OR = 0.001, p < 0.05). Based on the results of the logistic regression analysis, a risk prediction model for the prognosis of DFU patients was constructed using a nomogram. The ROC curve showed an AUC value of 0.937, with a 95% CI of 0.887 to 0.986. The calibration curve indicated that the model's predicted results were well aligned with the actual prognosis of DFU patients. The Cox-Snell R2 was 0.675, Nagelkerke R2 0.454, Brier Score 0.067, model fit p-value 0, and statistic 33.491. The clinical decision curve was generally above the two extreme curves, indicating that the factors included in the nomogram have a high net benefit for predicting the prognosis of DFU patients.<br /> ConclusionThere are numerous factors influencing the prognosis of DFU patients, primarily including IL-17, Th1 cells, Th2 cells, PCT, and CRP. The risk prediction nomogram model constructed based on these factors demonstrates good predictive performance for the risk of adverse outcomes in DFU patients and shows potential for clinical application in identifying high-risk individuals for targeted management strategies.
   Clinicians should identify high-risk populations early and optimize treatment strategies accordingly to improve outcomes.
C1 [Ding, Sheng; Gong, Yin; Ge, Zili] Soochow Univ, Affiliated Hosp 1, Dept Stomatol, 188 Shizi St, Suzhou City 215002, Jiangsu Provin, Peoples R China.
   [Ding, Sheng; Song, Mingming; Guo, Zaiwen; Sun, Ran; Liu, Yunfeng] Nanjing Med Univ, Suzhou Municipal Hosp, Dept Burns & Plast Surg, Affiliated Suzhou Hosp, Suzhou 215002, Jiangsu Provinc, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Ge, ZL (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Stomatol, 188 Shizi St, Suzhou City 215002, Jiangsu Provin, Peoples R China.
EM dingsheng0703@163.com
CR Alsabek MB, 2022, INT WOUND J, V19, P531, DOI 10.1111/iwj.13651
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   Chinese Elderly Type 2 Diabetes Prevention and Treatment of Clinical Guidelines Writing Group; Geriatric Endocrinology and Metabolism Branch of Chinese Geriatric Society; Geriatric Endocrinology and Metabolism Branch of Chinese Geriatric Health Care Society; Geriatric Professional Committee of Beijing Medical Award Foundation; National Clinical Medical Research Center for Geriatric Diseases(PLA General Hospital), 2022, CLIN GUIDELINES PREV
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NR 32
TC 1
Z9 2
U1 1
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD 2026 MAR 13
PY 2026
DI 10.1007/s13410-026-01636-9
EA MAR 2026
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FB3GS
UT WOS:001714673200001
DA 2026-07-24
ER

PT J
AU Hu, XY
   Meng, HX
   Liang, JR
   An, H
   Zhou, JQ
   Gao, YL
   You, C
   Zhang, ZN
   Gong, XY
   Liu, Y
AF Hu, Xuyang
   Meng, Huixin
   Liang, Jiaru
   An, Hang
   Zhou, Jiaqi
   Gao, Yuling
   You, Chong
   Zhang, Zhenni
   Gong, Xiaoyang
   Liu, Yong
TI Comparison of the efficacy of 12 interventions in the treatment of
   diabetic foot ulcers: a network meta-analysis
SO PEERJ
LA English
DT Article
DE Diabetic foot ulcers; Network meta-analysis; Wound healing rate; Wound
   healing time; Percentage area reduction; Amputation rate
ID HYPERBARIC-OXYGEN THERAPY; PLATELET-RICH PLASMA;
   EPIDERMAL-GROWTH-FACTOR; PRESSURE WOUND THERAPY; VACUUM-ASSISTED
   CLOSURE; LOWER-EXTREMITY ULCERS; DOUBLE-BLIND; CONTROLLED-TRIAL;
   MONONUCLEAR-CELLS; SHOCKWAVE THERAPY
AB Objective. This study aimed to comprehensively compare the efficacy of 12 interventions for diabetic foot ulcer (DFU) using a network meta-analysis (NMA). Methods. The NMA was conducted by PRISMA guidelines, and the protocol was registered in PROSPERO (CRD42023461811). PubMed, Web of Science, Cochrane Library, and Embase databases were systematically searched from inception to September 2023. Randomized controlled trials (RCTs) enrolling patients with DFU were included if they compared epidermal growth factor (EGF), platelet-derived growth factor (PDGF), platelet-rich plasma (PRP), stem cells (SC), low-frequency ultrasound (LFU), negative pressure wound therapy (NPWT), low-level laser therapy (LLLT), electric stimulation (ES), extracorporeal shockwave therapy (ESWT), amniotic membrane therapy (AMT), hyperbaric oxygen therapy (HBOT), and topical oxygen therapy (TOT) against standard of care (SOC) or placebo. The primary endpoint assessed was the wound healing rate. Secondary endpoints comprised wound healing time, percentage area reduction (PAR), and amputation rate. The surface under the cumulative ranking curve (SUCRA) was calculated to rank the efficacy of interventions. Results. A total of 99 RCTs involving 7,356 patients were included. Among the 12 interventions analyzed, only LFU (OR = 2.20; 95% CI [0.99-4.91]) and ES (OR = 1.88; 95% CI [0.87-4.05]) did not demonstrate statistically significant improvements in ulcer healing rate compared with SOC. Based on SUCRA rankings, SC (SUCRA = 89.7%; OR = 5.71; 95% CI [2.64-12.34]) and AMT (SUCRA = 89.2%; OR = 5.11; 95% CI [3.12-8.37]) ranked highest in promoting ulcer healing, while LFU (29.4%) and SOC (10.4%) ranked lowest. Regarding wound healing time, AMT (MD = -26.91 days; 95% CI [-44.27 to -9.55]), PRP (MD = -21.65 days; 95% CI [-33.61 to -9.69]), and NPWT (MD = -16.79 days; 95% CI [-31.12 to -2.26]) significantly reduced healing durations compared to SOC. SUCRA rankings indicated that AMT (84.7%) and PRP (74.6%) ranked highest, while LFU (29.4%) and SOC (10.4%) remained lowest. Concerning PAR, LLLT (MD = 34.27; 95% CI [17.35-51.20]) and ESWT (MD = 27.50; 95% CI [11.00-44.00]) showed significant improvements over SOC, with LLLT (SUCRA = 93.9%) and ESWT (SUCRA = 84.0%) ranking highest, while SOC (21.0%) and TOT (18.3%) ranked lowest. For amputation rate, SC (OR = 0.12; 95% CI [0.03-0.55]) and HBOT (OR = 0.35; 95% CI [0.16-0.78]) significantly lowered the risk compared to SOC, with SUCRA rankings placing SC (79.9%) and PRP (73.2%) as most effective, while NPWT (26.4%) and SOC (9.9%) were least effective. Conclusions. SC and AMT emerged as highly effective, demonstrating superior efficacy in improving healing rate compared to PDGF, ES, and HBOT. AMT also showed significant effects in shortening ulcer healing time. LLLT exhibited considerable effectiveness in reducing ulcer areas, and SC therapy was associated with reduced amputation rate.
C1 [Hu, Xuyang; Zhou, Jiaqi; Gao, Yuling; Zhang, Zhenni; Gong, Xiaoyang; Liu, Yong] Dalian Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Dalian, Peoples R China.
   [Hu, Xuyang; Meng, Huixin; Liang, Jiaru; An, Hang; You, Chong; Liu, Yong] Dalian Med Univ, Inst Coll Integrat Med, Dalian, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Gong, XY; Liu, Y (通讯作者)，Dalian Med Univ, Dept Rehabil Med, Affiliated Hosp 1, Dalian, Peoples R China.; Liu, Y (通讯作者)，Dalian Med Univ, Inst Coll Integrat Med, Dalian, Peoples R China.
EM rowlandgxy@163.com; fuwa52008@126.com
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NR 156
TC 5
Z9 6
U1 4
U2 6
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD AUG 11
PY 2025
VL 13
AR e19809
DI 10.7717/peerj.19809
PG 34
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7EM6Z
UT WOS:001569115000001
PM 40821981
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lumenta, DB
   Kamolz, LP
   Frey, M
AF Lumenta, David B.
   Kamolz, Lars-Peter
   Frey, Manfred
TI Adult Burn Patients With More Than 60% TBSA Involved-Meek and Other
   Techniques to Overcome Restricted Skin Harvest Availability-The Viennese
   Concept
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID POSTAGE STAMP AUTOGRAFTS; FLYPAPER TECHNIQUE; DERMAL SUBSTITUTE;
   ALLOGRAFT OVERLAY; WOUND CONTRACTION; PRESSURE THERAPY; EXTENSIVE BURNS;
   1ST EXPERIENCES; GRAFTS; ACTICOAT
AB Despite the fact that early excision and grafting has significantly improved outcome over the list decades, the management of severely burned adult patients with >= 60% total body surface area (% TBSA) burned still represents a challenging task for burn care specialists all over the world. In this article, we present our current treatment concept for this entity of severely bun-led patients and analyze its effect in a comparative cohort study. Surgical strategy comprised the use of split-thickness skin grafts (Meek, mesh) for permanent coverage, fluidized microsphere bead-beds for wound conditioning, temporary coverage (polyurethane sheets, Epigard (R); nanocrystalline silver dressings, Acticoat (R); synthetic copolymer sheets based on lactic acid, Suprathel (R); acellular bovine derived collagen matrices, Matriderm (R); allogeneic cultured keratinocyte sheets; and allogeneic split-thickness skill grafts),and negative-pressure wound therapy (vacuum-assisted closure). The autologous split-thickness skin graft expansion using the Meek technique for full-thickness burns and the delayed approach for treating dorsal burn wounds is discussed in detail. To demonstrate differences before and after the introduction of the Meek technique, we have compared patients of 2007 with >= 60% TBSA (n = 10) to those in a matched observation period (n = 7). In the first part of the comparative analysis, all patients of die two samples were analyzed with regard to age, abbreviated burn severity index, Baux, different entities of % TBSA, and survival. In die second step, only the survivors of both years were separated in two groups as follows: patients receiving skin grafts, using the Meek technique (n = 6), were compared with those without Meek grafting (n = 4). When comparing the severely burned patients of 2007 with a cohort of 2006, there were no differences for age (2007: 40.4 +/- 13.4 vs. 2006: 39.1 +/- 14.8 years), abbreviated burn severity index score (2007: 12.2 +/- 1.0 vs. 2006: 12.1 +/- 1.2) or % TBSA (2007: 72.1 +/- 11.7 vs. 2006: 69.3 +/- 8.7% TBSA). In these two rather small groups of severely burned patients with >= 60% TBSA, the overall survival rate of patients was 70.0% (7/10) in 2007 and 42.9% (3/7) in 2006, respectively. Almost all nonsurvivors in both years died within the first 5 days after admission. If assessing the different treatment modalities of till survivors, we found that although the Meek group patients were older (Meek 48.8 +/- 13.3 vs. non-Meek 26.8 +/- 11.5 years, P=.0381) and had consequently higher Bills scores (Meek 124.0 +/- 2.9 vs. non-Meek 93.8 +/- 8.5, P=.0095) than the non-Meek patients, this seemed to have no effect on length-of-stay (80.5 +/- 9.7 vs. non-Meek 79.8 +/- 33.0 days), hospital length-of-stay (85.7 +/- 14.8 vs. non-meek 84.3 +/- 26.1 days) or number of operations (6.5 +/- 1.0 vs. non-Meek 7.0 +/- 4.1 operations). The achieved results represent a combination of vinous treatment changes and, therefore, cannot be attributed to a single modality. The Meek technique is one of the technical options to choose from, to achieve permanent skin replacement; we think that it has its place if integrated in a whole treatment concept for management of severely burned patients. (J Burn Care Res 2009;30:231-242)
C1 [Lumenta, David B.; Kamolz, Lars-Peter; Frey, Manfred] Med Univ Vienna, Dept Surg, Div Plast & Reconstruct Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna
RP Kamolz, LP (通讯作者)，Med Univ Vienna, Dept Surg, Div Plast & Reconstruct Surg, Waehringer Gurtel 18-20, A-1090 Vienna, Austria.
RI Lumenta, David/AAD-5935-2019
OI Kamolz, Lars-Peter/0000-0002-5975-876X
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NR 54
TC 68
Z9 81
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2009
VL 30
IS 2
BP 231
EP 242
DI 10.1097/BCR.0b013e318198a2d6
PG 12
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 412QI
UT WOS:000263738900004
PM 19165111
DA 2026-07-24
ER

PT J
AU Liu, XL
   Huo, D
   Wu, GZ
AF Liu, Xilin
   Huo, Da
   Wu, Guangzhi
TI Deep Inferior Epigastric Flap Combined Bilateral-Anterolateral Thigh
   Flap for the Coverage of Both Lower Extremity Soft-Tissue Defect: A Case
   Report and a Literature Review
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Review
DE anterolateral thigh perforator flap; deep inferior epigastric perforator
   flap; soft tissue repair; skin repair
ID PERFORATOR FLAP; RECONSTRUCTION; SCALP
AB Background/Purpose: Anterolateral thigh perforator (ALTP) flap and deep inferior epigastric perforator (DIEP) flap have been advantageous over traditional myocutaneous flaps as they preserve the integrity of donor site muscles and minimize the damage and complication to donor site structures. Here, we reported the efficacy of free ALTP and DIEP in the repair of large skin area and soft tissue defects on both lower limbs after trauma.
   Case Report: A 19-year-old female traffic accident victim presented with multiple open bilateral fractures to the lower extremities with joint dislocation, massive skin and soft tissue defects, and multiple soft tissue contusion. Wounds on both lower extremities were covered with VSD (Vacuum Sealing Drainage). The tibiofibular and ankle joints on both lower limbs were fixed using external fixators. DIEP and ALTP flap were performed at different times.
   Results: After transfer, the vascular pedicle was anastomosed to the anterior tibial artery, posterior tibial artery, and the accompanying vein. After the operation, the donor site was directly closed and sutured. All flaps survived with a good appearance, leaving only a linear scar at the donor site.
   Conclusion: This case shows that free ALTP and DIEP flaps are ideal for repairing large skin area and soft tissue defects in bilateral lower limbs after trauma.
C1 [Liu, Xilin; Huo, Da; Wu, Guangzhi] Jilin Univ, Dept Hand Surg, China Japan Union Hosp, Changchun 130033, Peoples R China.
C3 Jilin University
RP Wu, GZ (通讯作者)，Jilin Univ, Dept Hand Surg, China Japan Union Hosp, Changchun 130033, Peoples R China.
EM wuguangzhi@jlu.edu.cn
RI Huo, Dacheng/MTF-4009-2025
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NR 19
TC 3
Z9 3
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2021
VL 14
BP 153
EP 161
DI 10.2147/CCID.S292053
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QI4JS
UT WOS:000618946200001
PM 33603432
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chen, F
   Shao, QQ
   Hu, JH
   Zhao, Y
   Wang, YP
   Zhang, JG
   Qiu, GX
AF Chen Feng
   Shao Qianqian
   Hu Jianhua
   Zhao Yu
   Wang Yipeng
   Zhang Jianguo
   Qiu Guixing
TI Treatment experience for full-thickness wound dehiscence with
   cerebrospinal fluid leakage following posterior primary spine surgery
   Three case reports
SO MEDICINE
LA English
DT Article
DE CSF leakage; full-thickness wound dehiscence; posterior primary spine
   surgery
ID MANAGEMENT; OSSIFICATION; DRAINAGE; RISK
AB Rationale: Full-thickness wound dehiscence with cerebrospinal fluid (CSF) leakage following posterior spine surgery is a rare but troublesome complication. In the present study, 3 clinical cases associated with this entity are reported.
   Patient concerns: The first case developed incision effusion 5 days after posterior decompression and internal fixation for lumbar spinal stenosis. The second case has the same diagnosis and treatment with the first case. She developed intraoperative CSF leak and incision effusion 7 days after the surgery. The third case developed incision effusion 6 days after posterior single door laminoplasty for cervical spondylosis.
   Diagnosis: All cases developed CSF leak, incision effusion and finally full-thickness wound dehiscence on the postoperative period.
   Interventions: Bed rest, drainage, vacuum sealing drainage (VSD), and reoperations were applied in all of the patients. Trapezius flap transfer was applied to the third case. One lumbar patient developed deep infection and meningitis; thus, the internal fixation and bone graft were removed.
   Outcomes: All of the patients received wound healing finally and were followed up for > 6 months. No incision complications reoccurred, and preoperative symptoms significantly relieved.
   Lessons: Several techniques can be adopted to minimize the incidence of complications and proper surgical repair is the most important. Lumbar cistern drainage and VSD are recommended. Some other available options of management will also help.
C1 Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped, Beijing, Peoples R China.
   Chinese Acad Med Sci, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College
RP Hu, JH (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped, Beijing 100730, Peoples R China.
EM pumch_hujianhua@163.com
RI ZHAO, YU/GZL-3154-2022
OI ZHAO, YU/0000-0001-9025-2014
FU China postdoctoral science foundation [2017M610813]
FX General financial grant from the China postdoctoral science foundation
   (2017M610813).
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   Hasegawa H, 2018, WORLD NEUROSURG, V114, pE1316, DOI [10.1016/J.WNEU.2018.03.209, 10.1016/j.wneu.2018.03.209]
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   2008, J BONE JOINT SURG AM, V90, P1101
NR 16
TC 9
Z9 11
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2019
VL 98
IS 15
AR e15126
DI 10.1097/MD.0000000000015126
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HX3YM
UT WOS:000467331500036
PM 30985675
OA Green Published, gold
DA 2026-07-24
ER

PT J
AU Yang, CX
   Liu, QY
   Chen, HY
AF Yang, Chenxi
   Liu, Quanyong
   Chen, Hongyi
TI Antibiotic-Loaded Bone Cement-Induced Membrane and Skin Grafting in
   Elderly Patients with Refractory Lower Limb Wounds
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID COST
AB Refractory lower limb wounds in the elderly population represent a significant and growing clinical challenge, often complicated by factors such as chronic infection, poor tissue vascularization, and multiple comorbidities. These wounds frequently lead to prolonged healing times, increased healthcare costs, and diminished quality of life for affected patients. This protocol article describes a detailed two-stage surgical technique that utilizes antibiotic-loaded polymethyl methacrylate (PMMA) bone cement to induce a vascularized membrane, followed by secondary skin grafting. The procedure is systematically outlined, beginning with patient selection criteria and progressing through radical wound debridement, intraoperative preparation and implantation of the vancomycin-loaded cement spacer, postoperative care, and subsequent spacer removal with application of a split-thickness skin graft onto the newly formed induced membrane. We provide a direct comparative framework against the conventional vacuum sealing drainage (VSD) technique. In this retrospective cohort study, representative results demonstrate that this method contributes to local infection control, as both groups showed a reduction in culture positivity postoperatively. Furthermore, it promotes a more robust angiogenic response within the induced membrane. Although the final wound healing rate at 70 days was comparable between groups, the PMMA method demonstrated a significantly shorter time to complete healing compared to VSD. The protocol also presents potential benefits in reducing the overall economic and psychological burden on patients. This comprehensive guide enables the replication of a promising surgical strategy for managing complex lower limb wounds in elderly patients.
C1 [Yang, Chenxi; Liu, Quanyong] Peoples Hosp Yuhuan, Dept Spine Hand & Foot Surg, Taizhou, Peoples R China.
   [Chen, Hongyi] Peoples Hosp Yuhuan, Dept Pathol, Yuhuan, Peoples R China.
RP Chen, HY (通讯作者)，Peoples Hosp Yuhuan, Dept Pathol, Yuhuan, Peoples R China.
EM chy960218@163.com
FU Taizhou Science and Technology Plan Project [23ywb148]
FX The authors thank the nursing staff and colleagues at the Department of
   Spine, Hand and Foot Surgery, The People's Hospital of Yuhuan, for their
   support in patient care and data collection. This work was supported by
   the Taizhou Science and Technology Plan Project (Grant No. 23ywb148) .
CR Anagnostakos K, 2009, J BIOMED MATER RES B, V90B, P467, DOI 10.1002/jbm.b.31281
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NR 21
TC 0
Z9 0
U1 1
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD FEB
PY 2026
IS 228
AR e70361
DI 10.3791/70361
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EL2HY
UT WOS:001703734100001
PM 41838703
DA 2026-07-24
ER

PT J
AU Wang, JC
   Wan, ZP
   Ma, XW
AF Wang, Jianchuan
   Wan, Zongpu
   Ma, Xiaowei
TI A strategy for the one-stage treatment of open Pilon fractures based on
   an accelerated rehabilitation surgical concept
SO CIRUGIA Y CIRUJANOS
LA English
DT Article
DE Open Pilon fracture; Emergency incisional reduction and internal
   fixation; Vacuum sealing drainage; Accelerated rehabilitation surgery
ID INTERNAL-FIXATION; EXTERNAL FIXATION; OPEN REDUCTION; INFECTION;
   MANAGEMENT; DEBRIDEMENT
AB Objective: The objective of the study was to study the strategy of one-stage emergency treatment of open Pilon fracture with the concept of accelerated rehabilitation surgery. Methods: The data of 18 patients with open Pilon fracture treated by first-stage emergency debridement, fracture internal fixation, bone grafting, negative pressure closed drainage covering the wound, leg incision reduction, and second-stage skin grafting or flap transfer in the Department of Orthopedics of our hospital from January 2014 to December 2018 were retrospectively analyzed. Joint surface reduction was evaluated by radiological evaluation criteria such as Burwell-Charnley, fracture healing quality was evaluated by Merchant score, and ankle joint function was evaluated by Tornetta and other criteria at the last follow-up. Results: All 18 patients were followed up, and the anatomical reduction rate was 94% (17/18) according to radiological evaluation criteria such as Burwell-Charnley. According to Merchant scoring criteria, the fracture healing rate was 83.3% (15/18). At the last follow-up, the ankle function was evaluated according to Tornetta and other criteria, and the excellent rate was 88.9% (16/18). Conclusions: Using the concept of accelerated rehabilitation surgery to treat open Pilon fractures in the first emergency can effectively avoid soft-tissue complications and is an effective treatment strategy.
C1 [Wang, Jianchuan; Wan, Zongpu; Ma, Xiaowei] Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China.
C3 Dalian University
RP Ma, XW (通讯作者)，Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Liaoning, Peoples R China.
EM 2573131767@qq.com
FU General Program from the Educational Commission of Liaoning Province of
   China [LJKZ0500]
FX The authors declare that they have received Funding. This research is
   financially funded by the General Program from the Educational
   Commission of Liaoning Province of China (Grant No. LJKZ0500) .
CR Al-Hourani K, 2019, J ORTHOP TRAUMA, V33, P591, DOI 10.1097/BOT.0000000000001562
   Bin Y, 2019, Chinese J Trauma Orthop, V21, P921
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NR 29
TC 0
Z9 0
U1 2
U2 2
PU MEXICAN ACAD SURGERY
PI MEXICO D G
PA CENTRO MED NAC SIGLO XXI, EDIFICIO BLOQUE B, SOTANO, AVE CUAUHTEMOC NO
   330, MEXICO D G, 06700, MEXICO
SN 0009-7411
J9 CIR CIR
JI Cir. Cir.
PD SEP-OCT
PY 2025
VL 93
IS 5
BP 474
EP 482
DI 10.24875/CIRU.24000013
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8ML9J
UT WOS:001592174200002
PM 40614248
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Li, RU
   Zeng, CJ
   Yuan, S
   Chen, YR
   Zhao, SW
   Ren, GH
AF Li, Runguang
   Zeng, Canjun
   Yuan, Song
   Chen, Yirong
   Zhao, Shanwen
   Ren, Gao-hong
TI Free flap transplantation combined with Ilizarov bone transport for the
   treatment of severe composite tibial and soft tissue defects
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Free flap transplantation; Ilizarov bone transport; soft tissue defect;
   open fracture; clinical efficacy; functional outcome
ID VACUUM SEALING DRAINAGE; EXTERNAL FIXATION; ORTHOFIX LRS;
   RECONSTRUCTION; OSTEOMYELITIS; OUTCOMES; FIBULA
AB Objective
   To evaluate the clinical efficacy of free flap transplantation combined with Ilizarov bone transport in the treatment of severe composite tibial and soft tissue defects.
   Methods
   We retrospectively analyzed the clinical data of 40 patients with severe composite tibial and soft tissue defects who underwent free flap transplantation combined with Ilizarov bone transport. The clinical efficacy was evaluated according to the following criteria: success rate of wound repair by free flap transplantation, incidence or recurrence rate of deep infection, healing rate of bone defects and external fixation index, incidence of complications, and functional score of affected extremities.
   Results
   All infections were generally well controlled by radical debridement and negative-pressure therapy, and all 40 patients' wounds healed after repair and reconstruction of the tibia and soft tissues. Postoperative complications were alleviated by active treatment. The mean external fixation time was 12.83 +/- 2.85 months, and the external fixation index was 1.55 m/cm. According to the Association for the Study and Application of Methods of Ilizarov (ASAMI) score, an excellent or good functional outcome was attained in 85% of patients.
   Conclusion
   Free flap transplantation combined with Ilizarov bone transport is an effective treatment for severe composite tibial and soft tissue defects.
C1 [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Southern Med Univ, Affiliated Hosp 3, Ctr Orthopaed Surg, Dept Foot & Ankle Surg, Guangzhou, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Orthopaed Hosp Guangdong Prov, Guangzhou, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Acad Orthopaed, Guangzhou, Guangdong, Peoples R China.
   [Li, Runguang; Zeng, Canjun; Zhao, Shanwen] Guangdong Prov Key Lab Bone & Joint Degenerat Dis, Guangzhou, Peoples R China.
   [Li, Runguang; Yuan, Song] Linzhi Peoples Hosp, Dept Orthoped, Linzhi, Peoples R China.
   [Chen, Yirong; Ren, Gao-hong] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, 1838th North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
   [Chen, Yirong; Ren, Gao-hong] Southern Med Univ, Nanfang Hosp, Key Lab Bone & Cartilage Regenerat Med, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Ren, GH (通讯作者)，Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, 1838th North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
EM doctor020@163.com
RI ; Zeng, CanJun/AHC-5294-2022; Chen, Yirong/T-8449-2019
OI Runguang, Li/0000-0002-4703-7180; 
FU Clinical Research Program of Nanfang Hospital, Southern Medical
   University [2020CR008, 2017KJB-GK-001]; Natural Science Foundation of
   Guangdong Province [2018A030313640, 2019A1515012176]
FX This work was supported by the Clinical Research Program of Nanfang
   Hospital, Southern Medical University (2020CR008); the Shanghai Wang
   Zhengguo Trauma Medical Development Foundation (2017KJB-GK-001); and the
   Natural Science Foundation of Guangdong Province (2018A030313640,
   2019A1515012176).
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NR 34
TC 8
Z9 8
U1 2
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY
PY 2021
VL 49
IS 5
AR 03000605211017618
DI 10.1177/03000605211017618
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UW6ST
UT WOS:000700283700001
PM 34044634
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hua, RY
   Gan, ZL
   Zhong, J
   Xian, JL
   Liang, YQ
   Deng, SP
   Zhu, CH
   Jiang, XL
AF Hua, Ruoyue
   Gan, Zilin
   Zhong, Jun
   Xian, Jianlin
   Liang, Yaoqi
   Deng, Shoupeng
   Zhu, Chonghao
   Jiang, Xiaolong
TI Non-clostridial gas gangrene involving the thyroid gland complicated by
   multiple infections in a diabetic patient: a case report
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Gas gangrene; thyroid gland; Escherichia coli; thyroidectomy; case
   report
AB The thyroid gland is usually resistant to infection due to its nature, including rich blood supply and lymphatic drainage. Gas gangrene involving the thyroid is extremely rare and may be related to preexisting thyroid disease or diabetes. Few related cases have been reported, among which non-clostridial gas gangrene (NCGG) is particularly uncommon. Here, we briefly describe the diagnosis and treatment of a rare NCGG case involving the right lobe of the thyroid gland. A 60-year-old female patient presented with neck pain accompanied by discomfort during eating, which acutely worsened with sudden neck swelling one day before admission. Laboratory examination revealed fever, significantly elevated blood glucose, restricted neck movement, increased local skin temperature, and palpable crepitus in the cervical region. Based on clinical assessment, the patient was diagnosed with acute suppurative thyroiditis complicated by gas gangrene and poorly controlled diabetes. Intraoperative findings and post-operative histopathologic examination supported the diagnosis of NCGG. A right thyroid lobectomy was performed, along with resection of the isthmus and the left inferior thyroid pole, followed by vacuum sealing drainage with polyurethane. The patient recovered well, with no evidence of recurrence or complications at the 4-month follow-up. Successful management of this condition requires early debridement, resection of necrotic tissue, appropriate drainage, and close monitoring for potential airway complications, such as tracheomalacia.
C1 [Hua, Ruoyue; Gan, Zilin; Zhong, Jun; Xian, Jianlin; Liang, Yaoqi; Deng, Shoupeng; Zhu, Chonghao; Jiang, Xiaolong] Wuzhou Gongren Hosp, Dept Wound Repair, Wuzhou 543000, Guangxi, Peoples R China.
RP Hua, RY (通讯作者)，Wuzhou Gongren Hosp, Dept Wound Repair, Wuzhou 543000, Guangxi, Peoples R China.
EM feelgood2000@163.com
CR ALWAKEEL J, 1995, ANN SAUDI MED, V15, P71, DOI 10.5144/0256-4947.1995.71
   Branca JJV, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58010137
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NR 10
TC 0
Z9 0
U1 1
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2026
VL 18
IS 4
BP 3403
EP 3407
DI 10.62347/JHCU2388
PG 5
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HW8UT
UT WOS:001764605100006
PM 42170444
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Liang, Y
   Liu, ZJ
   Wang, X
   Ma, Q
   Hu, XY
AF Liang, Yuan
   Liu, Zhenjiang
   Wang, Xin
   Ma, Qiang
   Hu, Xinyong
TI Experience in diagnosis and treatment of pediatric fibular osteomyelitis
SO FRONTIERS IN SURGERY
LA English
DT Article
DE fibula osteomyelitis; children; surgical intervention; vacuum sealing
   drainage; conservative treatment
ID MASQUELET TECHNIQUE
AB Objective To summarize and analyze the clinical characteristics, diagnosis, treatment, and prognosis of pediatric fibular osteomyelitis, and to analyze related influencing factors, providing evidence for clinical management of pediatric osteomyelitis in rare locations.Methods A retrospective analysis was conducted on the clinical data of pediatric patients with fibular osteomyelitis from January 2018 to December 2024, including demographic characteristics, clinical manifestations, laboratory and imaging examinations, microbiological results, treatment modalities, and follow-up outcomes.Results A total of 13 patients were included (9 males, 4 females) with a median age of onset of 7.3 years. There were 11 acute cases and 2 chronic cases. The main clinical manifestations were bone pain, fever, and local abscess formation. The positive rate of microbiological culture was 76.9%, with Staphylococcus aureus being the most common pathogen (including 1 case of MRSA). Two patients responded effectively to antibiotic therapy alone, while 11 cases required surgical intervention, including fibular fenestration, debridement, segmental resection, and VSD therapy. All patients showed significant reduction in inflammatory markers after treatment. During 3-24 months of follow-up, 3 cases experienced recurrence requiring repeat surgery, with no severe disability or deformity observed.Conclusion Pediatric fibular osteomyelitis has an insidious onset and poses diagnostic challenges. Staphylococcus aureus, particularly MRSA, represents the primary pathogen, with higher rates of surgical intervention and recurrence compared to other long bones. Early accurate diagnosis, adequate antibiotic therapy, and individualized surgical intervention are crucial for improving prognosis.
C1 [Liang, Yuan; Liu, Zhenjiang; Wang, Xin; Ma, Qiang; Hu, Xinyong] Capital Med Univ, Capital Inst Pediat, Capital Ctr Childrens Hlth, Dept Orthoped, Beijing, Peoples R China.
C3 Capital Institute of Pediatrics (CIP); Capital Medical University
RP Liu, ZJ (通讯作者)，Capital Med Univ, Capital Inst Pediat, Capital Ctr Childrens Hlth, Dept Orthoped, Beijing, Peoples R China.
EM lzjsdd@163.com
CR Bozkurt M, 2005, ARCH ORTHOP TRAUM SU, V125, P713, DOI 10.1007/s00402-005-0054-9
   Chen YM, 2023, BMC MED IMAGING, V23, DOI 10.1186/s12880-023-01010-9
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NR 16
TC 0
Z9 0
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD NOV 11
PY 2025
VL 12
AR 1671156
DI 10.3389/fsurg.2025.1671156
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D8040
UT WOS:001621899600001
PM 41306792
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hao, ZW
   Tian, S
   Hu, CQ
   Jia, Y
AF Hao, Zhiwei
   Tian, Shan
   Hu, Changqing
   Jia, Yan
TI Clinical application of retrograde sural neurofasciocutaneous flap
   repair combined with jingulian capsules to treat foot and ankle soft
   tissue defects
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Retrograde sural neurofasciocutaneous flap repair; Jingulian capsules;
   Soft tissue defect in the foot and ankle; Combination therapy
ID VENO-FASCIOCUTANEOUS FLAP; COMPLICATED SKIN; ANATOMICAL BASIS;
   INFECTIONS
AB Objectives: To observe and analyse the efficacy of retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules to treat foot and ankle soft tissue defects. Methods: One hundred and eighty patients with foot and ankle soft tissue defects were enrolled in the study from January 2016 to June 2019 in The Second Department of General Surgery,Baoding First Central Hospital. They were divided into a study group and a reference group with the same case number. The former group was provided combination treatment, i.e. retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules; the latter group was given vacuum sealing drainage. Then, the treatment outcomes of the two groups were compared. Results: The study group needed fewer dressing changes, less preoperative preparation time and antibiotic use than the reference group, p< 0.05. The study group had a significantly lower incidence of wound infections and flap necrosis than the reference group, p< 0.05. The study group was significantly superior to the reference group regarding ankle function scores and the pain visual analogue scores (VAS) p< 0.05. Conclusions: Retrograde sural neurofasciocutaneous flap repair combined with Jingulian capsules is a protocol that improves efficacy for soft tissue defects in the foot and ankle, which are worthy of promotion and practice.
C1 [Hao, Zhiwei] Baoding First Cent Hosp, Dept Gen Surg 2, Baoding 071000, Hebei, Peoples R China.
   [Tian, Shan] Baoding First Cent Hosp, Med Imaging Dept, Baoding 071000, Hebei, Peoples R China.
   [Hu, Changqing] Baoding First Cent Hosp, Orthopaed Dept 5, Baoding 071000, Hebei, Peoples R China.
   [Jia, Yan] Baoding First Cent Hosp, Phys Examinat, Baoding 071000, Hebei, Peoples R China.
RP Hao, ZW (通讯作者)，Baoding First Cent Hosp, Dept Gen Surg 2, Baoding 071000, Hebei, Peoples R China.
EM zhiwei197812@163.com
CR Cruz-Montecinos C, 2017, INT J CHRONIC OBSTR, V12, P691, DOI 10.2147/COPD.S127742
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NR 20
TC 5
Z9 5
U1 0
U2 6
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2022
VL 38
IS 1
BP 190
EP 194
DI 10.12669/pjms.38.1.4546
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YL4AY
UT WOS:000745836400033
PM 35035424
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, YY
   Yu, DJ
   Zhao, TL
   Dai, H
   Li, Y
   Bian, HH
   Chen, WB
   Zhang, YS
   Pu, WY
   Feng, JC
   Hu, WT
   Liu, YL
AF Wang, You-you
   Yu, Dao-jiang
   Zhao, Tian-lan
   Dai, Hong
   Li, Yuan
   Bian, Hua-hui
   Chen, Wei-bo
   Zhang, Yu-song
   Pu, Wang-yang
   Feng, Jun-chao
   Hu, Wen-tao
   Liu, Yu-long
TI Successful Rescue of the Victim Exposed to a Super High Dose of
   Iridium-192 during the Nanjing Radiological Accident in 2014
SO RADIATION RESEARCH
LA English
DT Article
ID RADIATION; MANAGEMENT
AB Here we report on the interventions taken to treat a patient exposed to high-dose radiation and provide a protocol for treating such patients in the future. The patient, Mr. Wang, was a 58-year-old male janitor who was accidentally exposed to a (192)Jr source with an activity of 966.4 GBq or 26.1 Ci. The dose estimated to the lower right limb was 4,100 Gy, whereas the whole-body effective dose was 1.51 Gy. The diagnosis was made according to the results of the patient dose estimation and clinical manifestations. Systemic treatment included stimulating bone marrow hematopoietic cells, enhancing immunity, anti-infection and vitamin supplements. The treatment of radiation-induced skin lesions consisted of several debridements, two skin-flap transplantations and application of mesenchymal stem cells (MSCs). Skin-flap transplantations and MSCs play important roles in the recovery of skin wound. A combination of antibiotics and antimycotic was useful in reducing inflammation. The application of vacuum sealing drainage was effective in removing necrotic tissue and bacteria, ameliorating ischemia and hypoxia of wound tissue, providing a fresh wound bed for wound healing and improving skin or flap graft survival rates. The victim survived the accident without amputation, and function of his highly exposed right leg was partially recovered. These results demonstrate the importance of collaboration among members of a multidisciplinary team in the treatment of this patient. (C) 2019 by Radiation Research Society
C1 [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Liu, Yu-long] Soochow Univ, Affiliated Hosp 2, Dept Nucl & Radiat Incident Med Emergency Off, Suzhou 215004, Peoples R China.
   [Yu, Dao-jiang; Zhao, Tian-lan] Soochow Univ, Affiliated Hosp 2, Dept Plast Surg, Suzhou 215004, Peoples R China.
   [Li, Yuan; Pu, Wang-yang] Soochow Univ, Affiliated Hosp 2, Dept Oncol & Occupat Med, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Soochow Univ, State Key Lab Radiat Med & Protect, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Soochow Univ, Sch Radiat Med & Protect, Suzhou 215004, Peoples R China.
   [Wang, You-you; Dai, Hong; Bian, Hua-hui; Chen, Wei-bo; Zhang, Yu-song; Feng, Jun-chao; Hu, Wen-tao; Liu, Yu-long] Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215004, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China; Soochow University - China; Soochow University -
   China
RP Liu, YL (通讯作者)，Soochow Univ, Nucl & Radiat Incident Med Emergency Off, Affiliated Hosp 2, Sanxiang Rd 1055, Suzhou 215004, Peoples R China.
EM yulongliu2002@126.com
RI Chen, Weibo/OQK-7236-2025
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   Chapel Alain, 2013, World J Stem Cells, V5, P68, DOI 10.4252/wjsc.v5.i3.68
   Eaton EB, 2015, MILITARY MED RES, V2, DOI 10.1186/s40779-014-0027-9
   Gorin NC, 2006, ANN HEMATOL, V85, P671, DOI 10.1007/s00277-006-0153-x
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   Wang Y, 2015, ACTA HAEMATOL-BASEL, V133, P72, DOI 10.1159/000362530
NR 9
TC 5
Z9 11
U1 0
U2 12
PU RADIATION RESEARCH SOC
PI LAWRENCE
PA 810 E TENTH STREET, LAWRENCE, KS 66044 USA
SN 0033-7587
EI 1938-5404
J9 RADIAT RES
JI Radiat. Res.
PD MAY
PY 2019
VL 191
IS 6
BP 527
EP 531
DI 10.1667/RR15274.1
PG 5
WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology,
   Nuclear Medicine & Medical Imaging
GA IB1BB
UT WOS:000469997300005
PM 30925136
DA 2026-07-24
ER

PT J
AU Kuzmiuk-Glembin, I
   Bialomyzy, A
   Sadowski, M
   Biedunkiewicz, B
   Tylicki, L
   Nieweglowski, T
AF Kuzmiuk-Glembin, Izabella
   Bialomyzy, Agnieszka
   Sadowski, Michal
   Biedunkiewicz, Bogdan
   Tylicki, Leszek
   Nieweglowski, Tomasz
TI The Combined Use of Ozone and Negative Pressure Wound Therapy in the
   Management of Diabetes-Related Foot Disease: A Retrospective Exploratory
   Cohort Study
SO MEDICINA-LITHUANIA
LA English
DT Article
DE ozone treatment; diabetic foot syndrome; negative pressure therapy;
   diabetes mellitus
ID OZONATED AUTOHEMOTHERAPY; ATHEROSCLEROTIC ISCHEMIA; RISK
AB Background and Objectives: Diabetes mellitus (DM) is a major global health concern, with diabetes-related foot disease (DFD) representing one of its most severe complications, often resulting in chronic infection, osteomyelitis, and limb amputation. Conventional therapies frequently fail in refractory cases, necessitating novel adjunctive strategies. Ozone therapy (OT) possesses antimicrobial, immunomodulatory, and oxygen-enhancing properties, while negative pressure wound therapy (NPWT) facilitates granulation, exudate removal, and tissue perfusion. This study explored the combined efficacy of OT and NPWT in advanced DFD. Materials and Methods: An exploratory, retrospective, observational cohort study was conducted at a specialized wound care center in Gda & nacute;sk, Poland, between 2019 and 2022. The study included 30 patients (n = 30) with refractory DFD involving both soft tissue and bone infection who had not responded to previous conventional treatment. The analyzed treatment approach consisted of surgical debridement, application of topical ozonated preparations, and (NPWT) with instillation of ozonated saline administered over a six-week period. Clinical outcomes included wound healing assessed using the Wagner classification and wound volume reduction, pain intensity measured using the Numeric Rating Scale (NRS), inflammatory biomarkers (C-reactive protein [CRP] and procalcitonin [PCT]), and microbiological characteristics of wound cultures. Statistical analyses were performed using the Wilcoxon signed-rank test and the chi-square test, and regression modeling was applied to identify potential predictors of therapeutic response. Statistical significance was defined as p < 0.05. Results: By week six, 100% of ulcers improved to Wagner stage <= 1, with 26.7% achieving stage 0. Median wound volume decreased from 5.5 cm(3) to 0 cm(3) (p < 0.001). Pain scores declined from 7.2 +/- 0.96 points to 0.2 +/- 0.5 points (p < 0.001). CRP and PCT levels decreased significantly (p < 0.001), and microbiological clearance was observed in all cases. Higher body mass index (BMI) was associated with poorer pain reduction. Conclusions: The combination of standard wound care with OT and NPWT was associated with clinically relevant improvements in wound healing, infection control, systemic inflammation, and pain reduction in patients with refractory DFD. Although limited by a non-controlled design and small cohort size, these findings support further randomized controlled trials to define the role of this combined approach in integrated diabetic foot care.
C1 [Kuzmiuk-Glembin, Izabella; Biedunkiewicz, Bogdan; Tylicki, Leszek] Med Univ Gdansk, Univ Clin Ctr, Dept Nephrol Transplantol & Internal Dis, PL-80214 Gdansk, Poland.
   [Bialomyzy, Agnieszka; Sadowski, Michal; Nieweglowski, Tomasz] Wound Care Clin, Nonpubl Healthcare Ctr, ETER MED, PL-80822 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Kuzmiuk-Glembin, I (通讯作者)，Med Univ Gdansk, Univ Clin Ctr, Dept Nephrol Transplantol & Internal Dis, PL-80214 Gdansk, Poland.
EM iza_kuzmiuk@gumed.edu.pl; tn@etermed.pl
RI Kuźmiuk-Glembin, Izabella/AAS-8938-2020; /R-1168-2018; Tylicki,
   Leszek/T-8466-2018
FU European Regional Development Fund under the Smart Growth Operational
   Programme 2014-2020
FX This research was conducted using clinical material and infrastructure
   as a part of a project co-financed by the European Regional Development
   Fund under the Smart Growth Operational Programme 2014-2020, Measure 2.1
   POIR, concerning the establishment of a Research and Development Centre
   at ETER-MED Sp. z o.o. for the development and implementation of novel
   therapeutic and technological methods in ozone therapy. The
   retrospective scientific analysis and manuscript preparation were
   performed subsequently.
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 27
PY 2026
VL 62
IS 5
AR 827
DI 10.3390/medicina62050827
EA APR 2026
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IO4PP
UT WOS:001776525300001
PM 42195080
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Arundel, C
   Mandefield, L
   Fairhurst, C
   Baird, K
   Gkekas, A
   Saramago, P
   Chetter, I
AF Arundel, Catherine
   Mandefield, Laura
   Fairhurst, Caroline
   Baird, Kalpita
   Gkekas, Athanasios
   Saramago, Pedro
   Chetter, Ian
CA SWHSI 2 Trial Investigators
TI Negative pressure wound therapy versus usual care in patients with
   surgical wound healing by secondary intention in the UK (SWHSI-2): an
   open-label, multicentre, parallel-group, randomised controlled trial
SO LANCET
LA English
DT Article
ID ALGINATE; CLOSURE
AB Background Surgical wound healing by secondary intention (SWHSI) presents a substantial management and financial challenge. Negative pressure wound therapy (NPWT) has increasingly been used as a treatment despite an absence of comparative evidence of effectiveness. We evaluated the effectiveness of NPWT compared with usual care for improving time to wound healing in patients with an SWHSI. Methods We did a pragmatic, open-label, multicentre, parallel-group, randomised controlled trial in 29 UK National Health Service Trusts. Participants aged 16 years or older with an SWHSI appropriate for both study treatments (NPWT or usual care) were randomly assigned (1:1) by a centralised web-based system. Randomisation was stratified by wound location, wound area, and study centre. Participants were followed up for 12 months. Participants and clinical and research teams could not be masked to treatment. Assessors masked to treatment reviewed wound photography to verify the outcome. The primary outcome was time to wound healing (days from randomisation to complete epithelial cover), analysed via intention to treat using Kaplan-Meier survival curves and a proportional hazards Cox regression model. The trial was registered with ISRCTN, ISRCTN26277546. Findings Between May 15, 2019, and Jan 13, 2023, 686 participants with an SWHSI were randomly assigned to receive NPWT (n=349) or usual care (n=337). All participants were included in the primary analysis. Most participants were diabetic (n=549, 80<middle dot>0%) and had a single SWHSI (n=622, 90<middle dot>7%), located on the foot or leg (n=620, 90<middle dot>4%), arising after vascular surgery (n=619, 90<middle dot>2%). There was no clear evidence that NPWT reduced the time to wound healing compared with usual care (hazard ratio 1<middle dot>08 [95% CI 0<middle dot>88-1<middle dot>32], p=0<middle dot>47). There were 448 adverse events, of which 14 were serious (nine participants in the NPWT group and five participants in the usual care group); 124 were deemed potentially related to treatment. NPWT was found not to be cost-effective compared with usual care. Interpretation In patients with a lower limb SWHSI, including those with complications of diabetes, there is no clear evidence that NPWT reduced the time to wound healing compared with standard dressings. These findings do not support the use of NPWT to augment SWHSI healing.
C1 [Arundel, Catherine; Mandefield, Laura; Fairhurst, Caroline; Baird, Kalpita; Gkekas, Athanasios] Univ York, York Trials Unit, York YO10 5DD, England.
   [Saramago, Pedro] Ctr Hlth Econ, York, England.
   [Saramago, Pedro] Univ York, York, England.
   [Chetter, Ian] Univ Hull, Fac Hlth Sci, Kingston Upon Hull, England.
   [Chetter, Ian] Hull York Med Sch, Kingston Upon Hull, England.
   [Chetter, Ian] Hull Univ Teaching Hosp NHSTrust, Kingston Upon Hull, England.
C3 University of York - UK; University of York - UK; University of York -
   UK; University of Hull; University of Hull; University of York - UK
RP Arundel, C (通讯作者)，Univ York, York Trials Unit, York YO10 5DD, England.
EM catherine.arundel@york.ac.uk
OI Mandefield, Laura/0000-0002-4219-5673; chetter, ian/0000-0002-2566-6859;
   Gkekas, Athanasios/0000-0003-4357-9043
FU National Institute for Health Research Health Technology Assessment
   Programme
FX National Institute for Health Research Health Technology Assessment
   Programme.
CR 3M, 3M Negative Pressure Wound Therapy (NPWT)
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NR 28
TC 20
Z9 24
U1 3
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD MAY 10
PY 2025
VL 405
IS 10490
BP 1689
EP 1699
DI 10.1016/S0140-6736(25)00143-6
EA JAN 2025
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3UC3R
UT WOS:001509043200022
PM 40250455
OA Green Accepted, Green Published, Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ensor, N
   Martin, S
   Chang, ANT
   Sharpin, C
   Tandon, S
   Madden, A
   Syme, D
   Pacilli, M
   Nataraja, R
AF Ensor, Nicholas
   Martin, Sarah
   Chang, Annette
   Sharpin, Claire
   Tandon, Sarthak
   Madden, Andrew
   Syme, Duncan
   Pacilli, Maurizio
   Nataraja, Ram
TI Negative Pressure Dressing Versus Conventional Passive Dressing in
   Pilonidal Surgery: A Randomized Controlled Trial
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Dehiscence; Karydakis; Negative pressure wound therapy; Pilonidal sinus;
   Primary closure
ID SINUS; COMPLICATIONS; FLAP; RISK
AB Introduction: Surgically treated pilonidal sinus disease (PSD) has high rates of postoperative wound complications, with surgical wound dehiscence (SWD) rates up to 44%. Negative pressure wound therapy (NPWT) is proposed to reduce rates of SWD for other high risk surgical wounds. Our aim was to investigate whether NPWT would reduce rates of SWD compared to conventional passive (CP) dressings for PSD excisions with off-midline primary closure. Our secondary outcomes included patient quality of life and time taken return to normal activities. Method: We performed a prospective, crossover pediatric/adult randomized controlled trial for patients (12-40 y) with PSD, requiring excision and off-midline primary closure. Participants were randomized to receive a CP (Primapore or Opsite) or NPWT (SNAP) dressing. Follow-up occurred on D3, D7, D10, D14 and then weekly until wound healing. Patients were sent a 2-month postoperative online survey to assess quality of life outcomes. Results: Fifty patients were recruited, 25 to NPWT & 25 to CP. Mean age and body mass index were 22.6 f 6.7 y and 26.1 f 4.5 kg/m(2), respectively. 36/50 (76%) were male. The overall dehiscence rate was 42% (21/50); 12/25 (48%) for NPWT & 9/25 (36%) for CP, P = 0.6. Five deep (>= 5 mm) SWDs occurred in each group, P > 0.9. SWD was associated with increased excision dimensions in the NPWT group only, P = 0.03. Median duration to wound healing was equivalent in nondehisced wounds, (CP 21.0 [14.0-29.5] versus NPWT 21.0 [16.0-24.0] days, P = 0.7). There were no differences in mean time to the following: return to school/work (NPWT 26.1 f 18.2 versus CP 29.3 f 14.7 d, P = 0.6), sit normally (NPWT 22.3 f 16.2 versus CP 20.1 f 9.4 d, P = 0.7), or return to physical activity (NPWT21.6 f 17.2 versus CP40.3 f 2.4 d, P = 0.2). Conclusions: NPWT did not improve outcomes after excision of PSD with off-midline primary closure. Despite the limited population size, our results do not support its use as a routine preventative measure. Crown Copyright (c) 2024 Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Ensor, Nicholas; Chang, Annette; Sharpin, Claire; Tandon, Sarthak; Pacilli, Maurizio; Nataraja, Ram] Monash Childrens Hosp, Dept Paediat Surg Urol & Surg Simulat, Melbourne, Australia.
   [Martin, Sarah] Monash Hlth, Dept Gen Surg, Melbourne, Australia.
   [Martin, Sarah; Pacilli, Maurizio; Nataraja, Ram] Monash Univ, Fac Med, Sch Clin Sci Nursing & Hlth Sci, Dept Surg, Melbourne, Australia.
   [Madden, Andrew; Syme, Duncan] Monash Hlth, Dept Hosp Home, Melbourne, Australia.
   [Pacilli, Maurizio; Nataraja, Ram] Monash Univ, Fac Med, Sch Clin Sci Nursing & Hlth Sci, Dept Paediat, Melbourne, Australia.
C3 Monash Health; Monash University; Monash Health; Monash University
RP Nataraja, R (通讯作者)，Monash Univ, Monash Childrens Hosp, Dept Paediat Surg, 246 Clayton Rd, Melbourne 3168, Australia.
EM ram.nataraja@monashhealth.org
RI Nataraja, Ramesh/AAI-2975-2020; Pacilli, Maurizio/O-3714-2017
OI Nataraja, Ramesh/0000-0003-4438-0263; Ensor,
   Nicholas/0000-0001-8528-0432; 
CR Arslan K, 2014, TECH COLOPROCTOL, V18, P29, DOI 10.1007/s10151-013-0982-2
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NR 20
TC 2
Z9 3
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2024
VL 303
BP 313
EP 321
DI 10.1016/j.jss.2024.09.016
EA OCT 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J6M3G
UT WOS:001338183700001
PM 39393119
DA 2026-07-24
ER

PT J
AU Fröschen, FS
   Walter, SG
   Randau, TM
   Gravius, N
   Gravius, S
   Hischebeth, GTR
AF Froeschen, Frank Sebastian
   Walter, Sebastian Gottfried
   Randau, Thomas Martin
   Gravius, Nadine
   Gravius, Sascha
   Hischebeth, Gunnar Thorben Rembert
TI The use of negative pressure wound therapy increases failure rate in
   debridement and implant retention for acute prosthetic joint infection
SO TECHNOLOGY AND HEALTH CARE
LA English
DT Article
DE Revision total joint arthroplasty; PJI; NPWT; reimplantation;
   multi-stage revision; risk factor
ID TOTAL KNEE ARTHROPLASTY; FAILED IRRIGATION; TOTAL HIP; OUTCOMES
AB BACKGROUND: To date only scanty data exist regarding the effect of failed debridement, antibiotics, irrigation and retention of the prostheses (DAIR) and negative pressure wound therapy (NPWT) on the outcome of a subsequent exchange arthroplasty.
   OBJECTIVE: The objective of this study was to determine the success rate of a two- or multi-stage procedure after initial failed DAIR/NPWT in patients with an acute periprosthetic joint infection (PJI) and to evaluate the influence of possible risk factors for treatment failure.
   METHODS: Nineteen consecutive patients with a persisting PJI and ongoing NPWT after treatment of an acute PJI with DAIR of the hip or knee joint from October 2010 to June 2017 were included. All patients were treated according to a structured treatment algorithm after referral to our hospital. The endpoint was a successful reimplantation with absence of signs of infection two years after replantation ("replantation group") or treatment failure ("treatment failure group") in terms of a permanent girdlestone arthroplasty, fistula, amputation or death. A risk factor analysis was performed between the two groups.
   RESULTS: Explantation was performed in 15 cases, amputation in one case, and DAIR/establishment of a fistula in three cases. The treatment success rate after reimplantation in terms of "definitively free of infection" two years after surgery according to Laffer was 36.85% (seven out of 19 patients). Statistical analysis revealed the number of surgeries until wound consolidation (p = 0.007), number of detected bacterial strains (p = 0.041), a polymicrobial PJI (p = 0.041) and detection of a difficult-to-treat organism (p = 0.005) as factors associated with treatment failure. After failed DAIR/NPWT we could detect a significant higher number of different bacterial strains ( p = 0.001).
   CONCLUSIONS: The treatment success rate after failed DAIR and NPWT with 36% is low and associated with a high treatment failure rate (permanent girdlestone arthroplasty, fistula or amputation, death). Thus, the definition of risk factors is crucial. We found that the number of revisions until wound consolidation, a polymicrobial PJI and detection of a difficult-to-treat organisms were risk factors for treatment failure. Furthermore, after failed DAIR/NPWT we could detect a significant higher number of different bacterial strains, with a possible adverse effect on a consecutive exchange.
C1 [Froeschen, Frank Sebastian; Walter, Sebastian Gottfried; Randau, Thomas Martin; Gravius, Nadine; Gravius, Sascha] Univ Hosp Bonn, Dept Orthopaed & Trauma Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
   [Gravius, Sascha] Heidelberg Univ, Univ Hosp Mannheim, Orthopaed & Trauma Surg Ctr, Med Fac Mannheim, Mannheim, Germany.
   [Hischebeth, Gunnar Thorben Rembert] Univ Hosp Bonn, Inst Med Microbiol Immunol & Parasitol, Bonn, Germany.
C3 University of Bonn; Ruprecht Karls University Heidelberg; University of
   Bonn
RP Fröschen, FS (通讯作者)，Univ Hosp Bonn, Dept Orthopaed & Trauma Surg, Sigmund Freud Str 25, D-53127 Bonn, Germany.
EM Frank.Froeschen@ukbonn.de
RI Randau, Thomas/AEP-9749-2022
OI Randau, Thomas/0000-0002-5224-9639
CR Argenson JN, 2019, J ARTHROPLASTY, V34, pS399, DOI 10.1016/j.arth.2018.09.025
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   Gardner J, 2011, CLIN ORTHOP RELAT R, V469, P970, DOI 10.1007/s11999-010-1417-2
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NR 29
TC 6
Z9 6
U1 0
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0928-7329
EI 1878-7401
J9 TECHNOL HEALTH CARE
JI Technol. Health Care
PY 2020
VL 28
IS 6
BP 721
EP 731
DI 10.3233/THC-192095
PG 11
WC Health Care Sciences & Services; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Engineering
GA PA3FR
UT WOS:000595521400013
PM 32444587
DA 2026-07-24
ER

PT J
AU Lempert, M
   Halvachizadeh, S
   Salfelder, CC
   Neuhaus, V
   Pape, HC
   Jukema, GN
AF Lempert, Maximilian
   Halvachizadeh, Sascha
   Salfelder, Clara Charlotte
   Neuhaus, Valentin
   Pape, Hans-Christoph
   Jukema, Gerrolt Nico
TI Long-term experience with a collagen-elastin scaffold in combination
   with split-thickness skin grafts for the treatment of full-thickness
   soft tissue defects: improvements in outcome-a retrospective cohort
   study and case report
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Matriderm (R); Skin grafting; Negative pressure wound therapy (NPWT);
   Bioburden; Full-thickness wounds; Dermal substitute
ID PRESSURE WOUND THERAPY; MATRIDERM; RECONSTRUCTION; EPIDEMIOLOGY;
   SYSTEMS; BURNS
AB Purpose The management of severe soft tissue injuries to the extremities with full-thickness wounds poses a challenge to the patient and surgeon. Dermal substitutes are used increasingly in these defects. The aim of this study was to investigate the impact of the type of injury on the success rate of Matriderm (R) (MD)-augmented split-thickness skin grafting, as well as the role of negative pressure wound therapy (NPWT) in preconditioning of the wounds, with a special focus on the reduction of the bioburden.
   Methods In this study, 45 wounds (44 affecting lower extremities (97.7%)), resulting from different types of injuries: soft tissue (ST), soft tissue complications from closed fracture (F), and open fracture (OF) in 43 patients (age 55.0 +/- 18.2 years, 46.7% female), were treated with the simultaneous application of MD and split-thickness skin grafting. The study was designed as a retrospective cohort study from March 2013 to March 2020. Patients were stratified into three groups: ST, F, and OF. Outcome variables were defined as the recurrence of treated wound defects, which required revision surgery, and the reduction of bioburden in terms of reduction of number of different bacterial strains. For statistical analysis, Student's t-test, analysis of variance (ANOVA), Mann-Whitney U test, and Pearson's chi-squared test were used.
   Results There was no significant difference in the rate of recurrence in the different groups (F: 0%; OF: 11.1%; ST: 9.5%). The duration of VAC therapy significantly differed between the groups (F: 10.8 days; OF: 22.7 days; ST: 12.6 days (p < 0.05)). A clinically significant reduction of bioburden was achieved with NPWT (bacterial shift (mean (SD), F: - 2.25 (1.89); OF: -1.9 (1.37); ST: - 2.6 (2.2)).
   Conclusion MD-augmented split-thickness skin grafting is an appropriate treatment option for full-thickness wounds with take rates of about 90%. The complexity of an injury significantly impacts the duration of the soft tissue treatment but does not have an influence on the take rate. NPWT leads to a relevant reduction of bioburden and is therefore an important part in the preconditioning of full-thickness wounds.
C1 [Lempert, Maximilian; Halvachizadeh, Sascha; Salfelder, Clara Charlotte; Neuhaus, Valentin; Pape, Hans-Christoph; Jukema, Gerrolt Nico] Univ Hosp Zurich, Dept Trauma, Raemistr 100, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Lempert, M (通讯作者)，Univ Hosp Zurich, Dept Trauma, Raemistr 100, CH-8091 Zurich, Switzerland.
EM maximiliam.lempert@usz.ch; sascha.halvachizadeh@usz.ch;
   Clara.salfelder@stud.uni-goettingen.de; valentin.neuhaus@usz.ch;
   hans-christoph.pape@usz.ch; gerroltnico.jukema@usz.ch
OI Pape, Hans-Christoph/0000-0002-2059-4980; Neuhaus,
   Valentin/0000-0003-4012-5628; Lempert, Maximilian/0000-0001-6934-5726
FU Universitat Zurich
FX Open Access funding provided by Universitat Zurich.
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NR 41
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD FEB
PY 2022
VL 407
IS 1
BP 327
EP 335
DI 10.1007/s00423-021-02224-7
EA SEP 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZB5LU
UT WOS:000693343300001
PM 34480629
OA Green Submitted, Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Lee, JH
   Kim, TG
AF Lee, Joon Hyuk
   Kim, Tae Gon
TI Quadrilateral Pinwheel Flap Reconstruction for a Complex Colocutaneous
   Fistula-Associated Flank Wound in a Paraplegic Patient: A Case Report
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE paraplegia; colonic fistula; surgical flaps; wound healing;
   negative-pressure wound therapy
ID ULCERS
AB Background/Objectives: Chronic wounds are a major source of morbidity in patients with paraplegia, often resulting in repeated treatment, prolonged hospitalization, and reduced quality of life. Reconstruction becomes particularly challenging when a wound arises in a scarred trunk region and is further complicated by deep infection, osteomyelitis, or enteric fistula. We describe the staged management of a complex left flank wound in a paraplegic patient, initially reconstructed with a quadrilateral pinwheel flap and later requiring multidisciplinary salvage for recurrence associated with rib osteomyelitis and a colocutaneous fistula. Methods: A paraplegic man in his 50s presented with a chronic left flank wound after repeated full-thickness skin graft failure and persistent Pseudomonas aeruginosa infection. After wide debridement, the approximately 7 & times; 7 cm defect was reconstructed with a quadrilateral pinwheel flap composed of four Limberg-style rhomboid fasciocutaneous flaps positioned at the 12, 3, 6, and 9 o'clock orientations, elevated at the level of the deep fascia, and transposed into the central defect, with adjunctive negative-pressure wound therapy (NPWT). Approximately 1 year later, recurrence with rib osteomyelitis required rib resection. During NPWT, feculent drainage led to the diagnosis of a colocutaneous fistula. Subsequent multidisciplinary treatment included fistula tract resection, colonic repair with omental patching, transposition of vascularized omentum into the chest wall cavity to obliterate dead space, continued NPWT, and delayed primary closure. Results: Initial local flap reconstruction achieved wound coverage, and immediate postoperative clinical assessment, including pinprick and refill testing, confirmed satisfactory flap perfusion; however, delayed recurrence developed in association with rib osteomyelitis. After definitive fistula surgery, dead-space management with vascularized omentum, wound conditioning with staged NPWT, and delayed primary closure, the wound healed completely. At 6 months after delayed closure, no recurrence of fistula, osteomyelitis, wound dehiscence, or soft-tissue breakdown was observed, and the patient's daily comfort and functional independence were improved compared with the preoperative condition. Conclusions: A quadrilateral pinwheel flap may provide an effective tension-dispersing local fasciocutaneous option for selected scarred trunk defects in high-risk patients. However, when chronic wounds are compounded by deep infection and enteric fistula, durable healing depends not on flap design alone but on staged multidisciplinary management incorporating definitive source control, vascularized tissue transfer for dead-space elimination, NPWT, and appropriately timed closure.
C1 [Lee, Joon Hyuk; Kim, Tae Gon] Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University
RP Kim, TG (通讯作者)，Yeungnam Univ, Coll Med, Dept Plast & Reconstruct Surg, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM mericle@naver.com; kimtg0919@gmail.com
CR Ghimire P, 2022, J NEPAL MED ASSOC, V60, P93, DOI 10.31729/jnma.5780
   Huda T, 2019, SURG J-NY, V5, pE113, DOI 10.1055/s-0039-1696728
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   Xiang YJ, 2024, BIOACT MATER, V39, P562, DOI 10.1016/j.bioactmat.2024.04.022
NR 11
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR 20
PY 2026
VL 15
IS 6
AR 2394
DI 10.3390/jcm15062394
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FR6PY
UT WOS:001725773300001
PM 41899317
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jayle, C
   Allain, G
   Buono, A
   Van, SD
   D'Ostrevy, N
   Kermen, S
   Picardo, A
   Pelras, A
   Drux, J
   Corbi, P
   Billot, M
   Frasca, D
AF Jayle, Christophe
   Allain, Geraldine
   Buono, Amandine
   Van, Simon Dang
   D'Ostrevy, Nicolas
   Kermen, Stephane
   Picardo, Alessandro
   Pelras, Antoine
   Drux, Julie
   Corbi, Pierre
   Billot, Maxime
   Frasca, Denis
TI Reduction of the risk of complete sternotomy scar dehiscence in cardiac
   surgery: a protocol for a randomised, open-label multicentre clinical
   investigation comparing negative pressure wound therapy (NPWT) versus
   standard dressing (PRISTER study)
SO BMJ OPEN
LA English
DT Article
DE Patients; Cardiac surgery; WOUND MANAGEMENT; Infection control
ID INFECTIONS; PREVENTION; MANAGEMENT
AB Introduction Cardiac surgical procedures are associated with a high incidence of postoperative infection, a risk attributed to their inherently invasive nature and extended duration. The goal of this study is to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with standard dressings in preventing sternal scar dehiscence in patients undergoing cardiac surgery via complete vertical midline sternotomy, comparing a 3 day change system (NPWT 3/7 d) versus a 7 day wear system (NPWT 7d) versus standard dressings.Methods and analysis The PRISTER study is a prospective open-label multicentre, randomised, controlled, three-arm trial. Patients aged >= 18 years and meeting all the following inclusion criteria: patients undergoing scheduled or semiurgent cardiac surgery, with or without extracorporeal circulation, and patients managed by complete vertical median sternotomy will be recruited. Total sample size will consist of 660 patients. The primary outcome, surgical wound dehiscence after complete median sternotomy, expressed as occurrence or non-occurrence during the first 30 postoperative days, will be assessed by tablet calibrated photos analysed by an independent blinded staff. The secondary outcomes will be the number of dressing repairs between D7 (excluding initial protocol) and D90, length of initial hospital stay, occurrence of surgical site infection and its classification collected on day 90 (D90), use of an anti-infectious treatment and its duration, incidence of postoperative mediastinitis defined by dehiscence of the sternum with positive sternal samples, incidence of surgical revision for dehiscence of the surgical wound at D90 and collection of all operations involving surgical revision of the sternotomy wound, number of rehospitalisations (including hospital consultations) and their duration (evaluated at D90). Medicoeconomic assessment will be assessed by evaluation of hospital and extrahospital costs (number of days in hospital, consultations, rehospitalisations, imaging, biology and drugs), dressing costs and patient quality of life by EQ-5D-5L.Ethics and dissemination The study was approved by the French Agency for the Safety of Health Products (ANSM, Agence National de S & eacute;curit & eacute; du M & eacute;dicament) as well as by the Ethics Committee (CPP Ile de France VIII) N degrees ID-RCB: 2023-A01782-43. Recruitment began in April 2024 and ended on 26 May 2025.Trial registration number clinicaltrials.gov NCT06207630.
C1 [Jayle, Christophe; Allain, Geraldine; Drux, Julie; Corbi, Pierre] CHU Poitiers, Serv Chirurg Thorac & Cardiovasc, Poitiers, France.
   [Jayle, Christophe; Buono, Amandine; Billot, Maxime] Univ Poitiers, Ctr Invest Clin Domaine Innovat Technol CIC IT 140, INSERM, CHU Poitiers, Poitiers, France.
   [Van, Simon Dang] Angers Univ Hosp, Serv Chirurg Cardiaque, Angers, France.
   [D'Ostrevy, Nicolas] CHU Clermont Ferrand, Serv Chirurg Cardiovasc, Clermont Ferrand, France.
   [Kermen, Stephane] CHU Tours, Serv Chirurg Cardiaque, Tours, France.
   [Picardo, Alessandro] CHU Limoges, Serv Chirurg Thorac & Cardiovasc, Limoges, France.
   [Pelras, Antoine] CHU Poitiers, Poitiers, France.
   [Billot, Maxime] Univ Poitiers, Ctr Rech Cognit & Apprentissage, UMR7295, CNRS, Poitiers, France.
   [Frasca, Denis] CHU Poitiers, Serv Anesthesie Reanimat & Med Perioperatoir, Poitiers, France.
C3 CHU Poitiers; Universite de Poitiers; CHU Poitiers; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Poitiers;
   Universite d'Angers; Centre Hospitalier Universitaire d'Angers;
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; CHU Tours; CHU
   Limoges; Universite de Poitiers; CHU Poitiers; Universite de Poitiers;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); CHU Poitiers; Universite de Poitiers
RP Billot, M (通讯作者)，Univ Poitiers, Ctr Invest Clin Domaine Innovat Technol CIC IT 140, INSERM, CHU Poitiers, Poitiers, France.; Billot, M (通讯作者)，Univ Poitiers, Ctr Rech Cognit & Apprentissage, UMR7295, CNRS, Poitiers, France.
EM christophe.jayle@chu-poitiers.fr; geraldine.allain@chu-poitiers.fr;
   amandine.buono@chu-poitiers.fr; simon.dangvan@chu-angers.fr;
   ndostrevy@chu-clermontferrand.fr; s.kermen@chu-tours.fr;
   Alessandro.Piccardo@chu-limoges.fr; Antoine.PELRAS@chu-poitiers.fr;
   Julie.DRUX@chu-poitiers.fr; pierre.corbi@chu-poitiers.fr;
   maxime.billot@chu-poitiers.fr; denis.frasca@chu-poitiers.fr
RI Billot, Maxime/J-3518-2012; d'ostrevy, nicolas/AAO-2100-2020
OI Billot, Maxime/0000-0003-0979-2182; 
FU French public health services [PHRC-N]
FX This study received funding in 2022 from the French public health
   services 'Direction Generale de l'Offre de Soins (DGOS)' through a
   National Hospital Clinical Research Program.
CR Biancari F, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154268
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Filsoufi F, 2009, J CARDIOTHOR VASC AN, V23, P488, DOI 10.1053/j.jvca.2009.02.007
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   Hawkins RB, 2019, J SURG RES, V240, P227, DOI 10.1016/j.jss.2019.02.046
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   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Musallam E, 2014, J VASC NURS, V32, P105, DOI 10.1016/j.jvn.2014.01.003
   Nherera LM, 2018, J CARDIOTHORAC SURG, V13, DOI 10.1186/s13019-018-0786-6
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   Zukowska A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11236991
NR 19
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV 18
PY 2025
VL 15
IS 11
AR e104226
DI 10.1136/bmjopen-2025-104226
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C0858
UT WOS:001620171400001
PM 41263903
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tahir, M
   Chaudhry, EA
   Zimri, FK
   Ahmed, N
   Shaikh, SA
   Khan, S
   Choudry, UK
   Aziz, A
   Jamali, AR
AF Tahir, M.
   Chaudhry, E. A.
   Zimri, F. K.
   Ahmed, N.
   Shaikh, S. A.
   Khan, S.
   Choudry, U. K.
   Aziz, A.
   Jamali, A. R.
TI 被撤回的出版物: Negative pressure wound therapy versus conventional dressing
   for open fractures in lower extremity trauma A MULTICENTRE RANDOMIZED
   CONTROLLED TRIAL (Retracted Article)
SO BONE & JOINT JOURNAL
LA English
DT Article; Retracted Publication
ID SURGICAL DEBRIDEMENT; LOWER-LIMB; INFECTION; DISABILITY; ADULTS
AB Aims
   It has been generally accepted that open fractures require early skeletal stabilization and soft-tissue reconstruction. Traditionally, a standard gauze dressing was applied to open wounds. There has been a recent shift in this paradigm towards negative pressure wound therapy (NPWT). The aim of this study was to compare the clinical outcomes in patients with open tibial fractures receiving standard dressing versus NPWT.
   Methods
   This multicentre randomized controlled trial was approved by the ethical review board of a public sector tertiary care institute. Wounds were graded using Gustilo-Anderson (GA) classification, and patients with GA-II to III-C were included in the study. To be eligible, the patient had to present within 72 hours of the injury. The primary outcome of the study was patient-reported Disability Rating Index (DRI) at 12 months. Secondary outcomes included quality of life assessment using 12-Item Short-Form Health Survey questionnaire (SF-12), wound infection rates at six weeks and nonunion rates at 12 months. Logistic regression analysis and independent-samples t-test were applied for secondary outcomes. Analyses of primary and secondary outcomes were performed using SPSS v. 22.0.1 and p-values of < 0.05 were considered significant.
   Results
   A total of 486 patients were randomized between January 2016 and December 2018. Overall 206 (49.04%) patients underwent NPWT, while 214 (50.95%) patients were allocated to the standard dressing group. There was no statistically significant difference in DRI at 12 months between NPWT and standard dressing groups (mean difference 0.5; 95% confidence interval (CI) -0.08 to 1.1; p = 0.581). Regarding SF-12 scores at 12 months follow-up, there was no significant difference at any point from injury until 12 months (mean difference 1.4; 95% CI 0.7 to 1.9; p = 0.781). The 30-day deep infection rate was slightly higher in the standard gauze dressing group. The non-union odds were also comparable (odds ratio (OR) 0.90, 95% CI 0.56 to 1.45; p = 0.685).
   Conclusion
   Our study concludes that NPWT therapy does not confer benefit over standard dressing technique for open fractures. The DRI, SF-12 scores, wound infection, and nonunion rates were analogous in both study groups. We suggest surgeons continue to use cheaper and more readily available standard dressings.
C1 [Tahir, M.; Ahmed, N.; Shaikh, S. A.; Jamali, A. R.] Jinnah Postgrad Med Ctr, Dept Orthopaed, Karachi, Pakistan.
   [Chaudhry, E. A.; Zimri, F. K.; Khan, S.; Choudry, U. K.; Aziz, A.] Jinnah Postgrad Med Ctr, Karachi, Pakistan.
   [Chaudhry, E. A.; Aziz, A.] Ghurkhi Trust Hosp, Dept Orthopaed, Lahore, Pakistan.
   [Zimri, F. K.] Natl Inst Rehabil Med, Dept Orthopaed, Islamabad, Pakistan.
   [Khan, S.] Whiston Hosp, Dept Orthopaed, Presoot, England.
   [Choudry, U. K.] Shifa Int Hopsital, Islamabad, Pakistan.
C3 Whiston Hospital
RP Tahir, M (通讯作者)，Jinnah Postgrad Med Ctr, Dept Orthopaed, Karachi, Pakistan.
EM doctor.muhammad.tahir@gmail.com
RI /U-5383-2019
CR [Anonymous], 2011, INJURY S1
   [Anonymous], 2018, JAMA J AM MED ASSOC, DOI DOI 10.1001/JAMA.2018.6452
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   Schulz KF, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-18
NR 18
TC 9
Z9 11
U1 0
U2 11
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD JUL
PY 2020
VL 102B
IS 7
BP 912
EP 917
DI 10.1302/0301-620X.102B7.BJJ-2019-1462.R1
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA ND4LV
UT WOS:000561874100016
PM 32600140
DA 2026-07-24
ER

PT J
AU LiBrizzi, CL
   Sabharwal, S
   Forsberg, JA
   Leddy, L
   Doung, YC
   Morris, CD
   Levin, AS
AF LiBrizzi, Christa L. L.
   Sabharwal, Samir
   Forsberg, Jonathan A. A.
   Leddy, Lee
   Doung, Yee-Cheen
   Morris, Carol D. D.
   Levin, Adam S. S.
TI Does the Use of Negative Pressure Wound Therapy and Postoperative Drains
   Impact the Development of Surgical Site Infections? A PARITY Trial
   Secondary Analysis
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID KNEE ARTHROPLASTY; BREAST SURGERY; RISK-FACTORS; HIP
AB Background:Surgical site infections (SSIs) represent a major complication following oncologic reconstructions. Our objectives were (1) to assess whether the use of postoperative drains and/or negative pressure wound therapy (NPWT) were associated with SSIs following lower-extremity oncologic reconstruction and (2) to identify factors associated with the duration of postoperative drains and with the duration of NPWT.Methods:This is a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial, a multi-institution randomized controlled trial of lower-extremity oncologic reconstructions. Data were recorded regarding the use of drains alone, NPWT alone, or both NPWT and drains, including the total duration of each postoperatively. We analyzed postoperative drain duration and associations with tourniquet use, intraoperative thromboprophylaxis or antifibrinolytic use, incision length, resection length, and total operative time, through use of a linear regression model. A Cox proportional hazards model was used to evaluate the independent predictors of SSI.Results:Overall, 604 patients were included and the incidence of SSI was 15.9%. Postoperative drains alone were used in 409 patients (67.7%), NPWT alone was used in 15 patients (2.5%), and both postoperative drains and NPWT were used in 68 patients (11.3%). The median (and interquartile range [IQR]) duration of drains and of NPWT was 3 days (IQR, 2 to 5 days) and 6 days (IQR, 4 to 8 days), respectively. The use of postoperative drains alone, NPWT alone, or both drains and NPWT was not associated with SSI (p = 0.14). Increased postoperative drain duration was associated with longer operative times and no intraoperative tourniquet use, as shown on linear regression analysis (p < 0.001 and p = 0.03, respectively). A postoperative drain duration of & GE;14 days (hazard ratio [HR], 3.6; 95% confidence interval [CI], 1.3 to 9.6; p = 0.01) and an operative time of & GE;8 hours (HR, 4.5; 95% CI, 1.7 to 11.9; p = 0.002) were independent predictors of SSI following lower-extremity oncologic reconstruction.Conclusions:A postoperative drain duration of & GE;14 days and an operative time of & GE;8 hours were independent predictors of SSI following lower-extremity oncologic reconstruction. Neither the use of postoperative drains nor the use of NPWT was a predictor of SSI. Future research is required to delineate the association of the combined use of postoperative drains and NPWT with SSI.
C1 [LiBrizzi, Christa L. L.; Sabharwal, Samir; Forsberg, Jonathan A. A.; Levin, Adam S. S.] Johns Hopkins Univ, Dept Orthopaed Surg, Div Orthopaed Oncol, Sch Med, Baltimore, MD 21205 USA.
   [Leddy, Lee] Med Univ South Carolina, Dept Orthopaed Surg, Charleston, SC USA.
   [Doung, Yee-Cheen] Oregon Hlth & Sci Univ, Dept Orthopaed & Rehabil, Portland, OR USA.
   [Morris, Carol D. D.] Mem Sloan Kettering Canc Ctr, Div Orthopaed Surg, New York, NY USA.
C3 Johns Hopkins University; Medical University of South Carolina; Oregon
   Health & Science University; Memorial Sloan Kettering Cancer Center
RP Levin, AS (通讯作者)，Johns Hopkins Univ, Dept Orthopaed Surg, Div Orthopaed Oncol, Sch Med, Baltimore, MD 21205 USA.
EM clibriz1@jhmi.edu; ssabhar1@jhmi.edu; jforsbe1@jh.edu; leddyl@musc.edu;
   doung@ohsu.edu; morrisc@mskcc.org; alevin25@jhmi.edu
RI ; Forsberg, Jonathan/K-2116-2012; Sabharwal, Samir/AAK-2427-2020
OI LiBrizzi, Christa/0000-0003-0214-4406; Forsberg,
   Jonathan/0000-0003-3835-0615; Morris, Carol/0000-0002-4007-9476;
   Sabharwal, Samir/0000-0003-3250-6615; Levin, Adam/0000-0003-0450-7821
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NR 26
TC 7
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD JUL 19
PY 2023
VL 105
IS SUPPL 1
SU 1
BP 34
EP 40
DI 10.2106/JBJS.22.01185
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA M9RR5
UT WOS:001033518500008
PM 37466578
DA 2026-07-24
ER

PT J
AU Monami, M
   Scatena, A
   Ragghianti, B
   Miranda, C
   Monge, L
   Silverii, A
   Uccioli, L
   Vermigli, C
AF Monami, Matteo
   Scatena, Alessia
   Ragghianti, Benedetta
   Miranda, Cesare
   Monge, Luca
   Silverii, Antonio
   Uccioli, Luigi
   Vermigli, Cristiana
CA Panel Italian Guidelines Treatment Diabetic Foot Syndrome
   SID AMD
TI Effectiveness of most common adjuvant wound treatments (skin
   substitutes, negative pressure wound therapy, hyperbaric oxygen therapy,
   platelet-rich plasma/fibrin, and growth factors) for the management of
   hard-to-heal diabetic foot ulcers: a meta-analysis of randomized
   controlled trials for the development of the Italian Guidelines for the
   Treatment of Diabetic Foot Syndrome
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Adjuvant therapy; Diabetic foot ulcers; Healing; Meta-analysis;
   Guidelines
ID CONTROLLED CLINICAL-TRIAL; ACELLULAR DERMAL MATRIX; LOWER-EXTREMITY
   ULCERS; DOUBLE-BLIND; MULTICENTER; EFFICACY; PLASMA; SAFETY; AMPUTATION;
   CLOSURE
AB AimTo assess the effects of several adjuvant therapies (AT) commonly used in the treatment of diabetic foot ulcers (DFU). The present meta-analysis was designed to support the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome.MethodsA Medline and Embase search were performed up to May 20th, 2024 collecting all RCTs including diabetic patients or reporting subgroup analyses on diabetic patients with DFU comparing AT with placebo/standard of care (SoC), with a duration of at least 12 weeks. Prespecified endpoints were: ulcer healing (principal), time-to-healing, major and minor amputation, serious adverse events (SAE), and all-cause mortality. AT assessed were: growth factors (GF), Platelet-rich plasma and fibrin (PRP/F), skin substitutes (SS), negative pressure wound therapy (NPWT), and hyperbaric oxygen therapy (HBOT). Mantel-Haenzel Odds ratios and 95% confidence intervals (MH-OR, 95% CIs) were either calculated or extracted directly from the publications. Weighted mean differences and 95% CIs were calculated for continuous variables.ResultsFifty-one studies fulfilled all inclusion criteria (3, 5, 27, 8, and 8 with GF, PRP/F, SS, NPWT, and HBOT, respectively). Participants treated with any of the explored AT had a significantly higher ulcer healing rate (MH-OR ranging from 2.17 to 4.18) and shorter time-to-healing in comparison with SoC/placebo. Only PRP/F and HBOT showed a significantly lower risk of major amputation (MH-OR: 0.32(0.11;0,93; p = 0.04 and 0.28(0.10;0,79; p = 0.02, respectively), despite a higher risk of SAE. No other significant effects on the above-reported prespecified endpoints were observed. For the primary endpoint, the quality of evidence was rated as "high" for all the AT, except for NPWT ("moderate").ConclusionsIn conclusion, AT can actively promote wound healing and shorten time-to-healing in patients with DFU. HBOT and PRP/F also showed a reduction of the risk of major amputation, despite a higher rate of SAE.
C1 [Monami, Matteo; Ragghianti, Benedetta; Silverii, Antonio] Azienda Osped Univ Careggi, Florence, Italy.
   [Monami, Matteo; Ragghianti, Benedetta; Silverii, Antonio] Univ Florence, Florence, Italy.
   [Scatena, Alessia] San Donato Hosp, Hlth Author South East Tuscany, Arezzo, Italy.
   [Miranda, Cesare] Pordenone Hosp, Pordenone, Italy.
   [Monge, Luca] AMD Italian Assoc Clin Diabetologists, Rome, Italy.
   [Uccioli, Luigi] Univ Rome, Diabet Sect, CTO Hosp, Rome, Italy.
   [Uccioli, Luigi] Tor Vergata Univ Rome, Dept Biomed & Prevent, Rome, Italy.
   [Scatena, Alessia; Ragghianti, Benedetta; Miranda, Cesare; Monge, Luca; Silverii, Antonio; Uccioli, Luigi; Vermigli, Cristiana] Azienda Sanit Friuli Occidentale, Pordenone, Italy.
   [Scatena, Alessia; Ragghianti, Benedetta; Miranda, Cesare; Monge, Luca; Silverii, Antonio; Uccioli, Luigi; Vermigli, Cristiana] Assoc Volontariato Piede Diabetico Umbria ODV, Perugia, Italy.
   [Vermigli, Cristiana] Univ Hosp Perugia, Perugia, Italy.
   Careggi Teaching Hosp, Diabetic Foot Unit, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; IRCCS Policlinico San Donato; Sapienza
   University Rome; University of Rome Tor Vergata; University of Florence;
   Azienda Ospedaliero Universitaria Careggi
RP Monami, M (通讯作者)，Azienda Osped Univ Careggi, Florence, Italy.; Monami, M (通讯作者)，Univ Florence, Florence, Italy.
EM matteo.monami@unifi.it
RI Monami, Matteo/L-4074-2019; Monge, Luca/ADD-0944-2022; Miranda,
   Cesare/HPF-1122-2023; uccioli, luigi/AAF-4844-2020; Silverii, Giovanni
   Antonio/ACQ-6013-2022
OI Monge, Luca/0000-0002-0506-1019; Miranda, Cesare/0000-0002-9247-8372;
   Silverii, Giovanni Antonio/0000-0002-6695-3213
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NR 94
TC 7
Z9 7
U1 3
U2 11
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUL
PY 2025
VL 62
IS 7
BP 1081
EP 1095
DI 10.1007/s00592-024-02426-7
EA DEC 2024
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5FG9Q
UT WOS:001383454900001
PM 39724338
DA 2026-07-24
ER

PT J
AU Dosluoglu, HH
   Loghmanee, C
   Lall, P
   Cherr, GS
   Harris, LM
   Dryjski, ML
AF Dosluoglu, Hasan H.
   Loghmanee, Cyrus
   Lall, Purandath
   Cherr, Gregory S.
   Harris, Linda M.
   Dryjski, Maciej L.
TI Management of early (&lt;30 day) vascular groin infections using
   vacuum-assisted closure alone without muscle flap coverage in a
   consecutive patient series
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the Society-for-Clinical-Vascular-Surgery
CY MAR 18-21, 2009
CL Ft Lauderdale, FL
SP Soc Clin Vasc Surg
ID PROSTHETIC GRAFT INFECTIONS; NEGATIVE-PRESSURE; SYNTHETIC GRAFTS;
   THERAPY; PRESERVATION; EXPERIENCE; BYPASS; SARTORIUS; OUTCOMES; SURGERY
AB Objective: Vacuum-assisted closure (VAC) therapy without muscle flap coverage is our primary approach for graft preservation in early, deep groin infections with and without exposed grafts; however, concerns exist regarding its safety. We report our experience in a consecutive series of patients with early groin infections managed without muscle flap closure.
   Methods: All patients with early (<30 day), deep vascular groin infections without (Szilagyi II) or with (Szilagyi exposed vascular graft or suture line between January 2004 and December 2008 were reviewed. Graft preservation followed by local wound care with VAC was attempted in all with intact anastomoses, patent grafts, and absence of systemic sepsis. Szilagyi classification, microorganism cultured, duration of VAC use, time to healing, additional interventions, and follow-up data (limb salvage, survival) were analyzed.
   Results: Twenty-two patients (26 groins, mean age 69.1 +/- 9.5 years [range, 44-86 years]) presented with deep groin infections 16 +/- 5 days (range, 7-28 days) after the index procedure (bypass-polytetrafluoroethylene [n = 11], autologous vein [n = 3], endarterectomy/patch [n = 6], extra-anatomic bypass [n = 5], percutaneous closure device [n = 1]). Grafts were exposed in 12 groins (Szilagyi III, nine with suture lines). VAC was started one to six days (median, three) after operative debridement. All had positive wound cultures and received culture-directed antibiotic therapy for 47 45 days (range, 14-180 days). Length of stay was significantly more in Szilaui III, whereas mean VAC use and time-to-healing were similar. Mean follow-up was 33.4 +/- 19.5 months (range, 2-72 months). All wounds healed (mean, 49 +/- 21 days). Two treatment failures occurred in the Szilagyi III group (17%). One patient had bleeding from the anastomotic heel eight days after debridement, had graft removal/in situ replacement and one presented with reinfection on day 117 and had partial graft removal/extra-anatomic bypass. There was no perioperative mortality or limb loss, but six late unrelated mortalities and one amputation at 46 months unrelated to the groin infection.
   Conclusions:Management of early, deep groin wound infections with debridement, antibiotics, and VAC treatment is safe and enables graft preservation in the majority of patients with minimal morbidity, no perioperative limb loss, or mortality. (J Vase Surg 2010;51:1160-6.)
C1 [Dosluoglu, Hasan H.; Lall, Purandath] Vet Affairs Med Ctr, Div Vasc Surg, Minnepolis, MN USA.
   [Dosluoglu, Hasan H.; Loghmanee, Cyrus; Cherr, Gregory S.; Harris, Linda M.; Dryjski, Maciej L.] SUNY Buffalo, Div Vasc Surg, Dept Surg, Buffalo, NY 14260 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Dosluoglu, HH (通讯作者)，VA Western NY Healthcare Syst, 3495 Bailey Ave, Buffalo, NY 14215 USA.
EM dosluoglu@yahoo.com
RI Harris, Linda/HGD-5419-2022
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NR 31
TC 86
Z9 98
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD MAY
PY 2010
VL 51
IS 5
BP 1160
EP 1166
DI 10.1016/j.jvs.2009.11.053
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA 590HL
UT WOS:000277216000013
PM 20356703
OA Bronze
DA 2026-07-24
ER

PT J
AU Crowe, CS
   Luan, A
   Lee, GK
AF Crowe, Christopher S.
   Luan, Anna
   Lee, Gordon K.
TI Hospital Transfer of Open Tibial Fractures Requiring Microsurgical
   Reconstruction Negatively Impacts Clinical Outcomes
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE lower extremity; trauma; microsurgery; open fracture; tibia fracture;
   hospital transfer
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; SOFT-TISSUE
   RECONSTRUCTION; LONG-BONE FRACTURES; SOLEUS MUSCLE; WOUND CLOSURE; MAJOR
   TRAUMA; MANAGEMENT; INFECTION; THERAPY
AB Introduction: Open tibial fractures are orthopedic emergencies that may present with severe soft tissue damage. Free tissue transfer is often required when local tissues are insufficient and patients may require hospital transfer to tertiary care centers for this purpose. Although the negative impact of inter-facility transfer has been well demonstrated in trauma patients, less is known regarding transfers for lower extremity injury patients. This study investigates differences in outcomes based on transfer status after open tibial fracture.
   Methods: Thirty-four consecutive open tibial fractures requiring free tissue transfer over a 13-year period (2001-2014) were retrospectively reviewed. Patients transferred from outside facilities were compared to non-transferred patients in regards to demographics, injury, surgical characteristics, and outcomes (mean follow-up of 2.5 years). Student t tests and chi square analysis were used to compare means and proportions, respectively.
   Results: One-half of patients were transferred from an outside hospital. Transferred and nontransferred patients were not significantly different in regard to age, sex, comorbidities, mechanism of injury, and Gustilo grade. There was no significant difference in the method of bony fixation or free flap used for soft tissue coverage. The time to wound vacuum-assisted closure placement was longer in transferred patients, though this difference was not found to be significant (2.4 vs 3.3 days, P = 0.55). Time to definitive bony fixation was delayed in the transfer group by 9 days (5.2 vs 14.1 days, P = 0.05) and to tissue coverage by 7 days (14.2 vs 20.9 days, P = 0.13). Rates of flap loss and amputation did not differ between the groups. However, transferred patients were more likely to develop osteomyelitis (risk ratio [RR], 3.0; P = 0.03), nonunion (RR, 5.0; P = 0.09), and require hardware removal (RR, 3.3; P = 0.01).
   Conclusions: Transferred and nontransferred patients were not significantly different in their demographics or presentation. However, an analysis of clinical outcomes showed that transfer was associated with increased rates of osteomyelitis, nonunion, and hardware removal. Although likely multifactorial, this study suggests that a delay to definitive fixation and soft tissue coverage contributes to the increased rate of complications and poorer prognosis.
C1 [Crowe, Christopher S.; Luan, Anna; Lee, Gordon K.] Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Palo Alto, CA 94304 USA.
C3 Stanford University
RP Lee, GK (通讯作者)，Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, 770 Welch Rd,Suite 400, Palo Alto, CA 94304 USA.
EM glee@stanford.edu
CR Almeida MF, 2002, PLAST RECONSTR SURG, V109, P583, DOI 10.1097/00006534-200202000-00027
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NR 40
TC 11
Z9 15
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2017
VL 78
SU 4
BP S180
EP S184
DI 10.1097/SAP.0000000000000972
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EX0JL
UT WOS:000402906400003
PM 28118229
DA 2026-07-24
ER

PT J
AU Burlew, CC
   Moore, EE
   Biffl, WL
   Bensard, DD
   Johnson, JL
   Barnett, CC
AF Burlew, Clay Cothren
   Moore, Ernest E.
   Biffl, Walter L.
   Bensard, Denis D.
   Johnson, Jeffrey L.
   Barnett, Carlton C.
TI One hundred percent fascial approximation can be achieved in the
   postinjury open abdomen with a sequential closure protocol
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 118th Scientific Session of the Western-Surgical-Association
CY NOV 07-10, 2010
CL Chicago, IL
SP Western Surg Assoc
DE Trauma; open abdomen; fascial closure; damage control surgery; delayed
   closure; abbreviated laparotomy
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; TRAUMA PATIENTS;
   WOUND CLOSURE; VENTRAL HERNIA; EXPERIENCE
AB BACKGROUND: Multiple techniques have been introduced to obtain fascial closure for the open abdomen. Vacuum-assisted closure has reduced but not eliminated the use of either split-thickness skin grafts to cover the exposed bowel or mesh (prosthetic or biological) approximation of the fascia. We hypothesized that a sequential closure technique performed by a systematic protocol would achieve a higher rate of primary fascial closure than other described techniques.
   METHODS: Our technique of sequential fascial closure was initiated in 2005. Patients with a postinjury open abdomen undergoing the technique were compared with those patients who did not follow the protocol. In brief, vacuum-assisted closure white sponges cover the bowel; the fascia is placed under moderate tension over the white sponges with no. 1-polydioxanone sutures; the black sponge is placed on top of this with the standard occlusive dressing; patients undergo partial fascial closure and replacement of the sponge sandwich every 2 days until completely closed. Protocol violations were defined as not returning to the operating room every other day and absence of fascial retention sutures. Patients who died before return to the operating room in the first 48 hours were excluded.
   RESULTS: One hundred consecutive patients underwent damage control surgery during the five-year study period and survived to second laparotomy; 49 patients attained fascial closure at the second laparotomy. Fifty-one patients required an open abdomen after the second laparotomy and comprise the study population. The majority were men (80%) with a mean age of 34.7 years +/- 2.0 years, mean injury severity score of 37.1 +/- 2.4, and mean abdominal trauma index of 26.4 +/- 2.1. Average initial base deficit was 15.7 +/- 0.6 and 24-hour red cell transfusions were 20.4 +/- 2.4 units. Of the 51 patients, 29 followed the protocol and 100% had fascial closure. Of the 22 patients who did not follow the protocol, 12 (55%) attained fascial closure. There were no significant differences in injury severity score, abdominal trauma index, base deficit, or red cell transfusions between the two groups.
   CONCLUSIONS: A methodical approach with sequential fascial closure achieves 100% fascial approximation in our experience. This technique reduces the morbidity of the open abdomen and the cost of either complex abdominal reconstruction or biological mesh insertion. (J Trauma. 2012;72: 235-241. Copyright (C) 2012 by Lippincott Williams & Wilkins)
C1 [Burlew, Clay Cothren] Denver Hlth Med Ctr, Dept Surg, Surg Intens Care Unit, Denver, CO 80204 USA.
   Univ Colorado, Denver, CO 80202 USA.
C3 Denver Health Medical Center; University of Colorado System; University
   of Colorado Denver
RP Burlew, CC (通讯作者)，Denver Hlth Med Ctr, Dept Surg, Surg Intens Care Unit, 777 Bannock St,MC 0206, Denver, CO 80204 USA.
EM clay.cothren@dhha.org
CR APRAHAMIAN C, 1990, J TRAUMA, V30, P719, DOI 10.1097/00005373-199006000-00011
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Bee TK, 2008, J TRAUMA, V65, P337, DOI 10.1097/TA.0b013e31817fa451
   Byrnes MC, 2010, AM J SURG, V199, P359, DOI 10.1016/j.amjsurg.2009.08.033
   Cipolla J, 2005, AM SURGEON, V71, P202
   Collier B, 2007, JPEN-PARENTER ENTER, V31, P410, DOI 10.1177/0148607107031005410
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   Weinberg JA, 2008, J TRAUMA, V65, P345, DOI 10.1097/TA.0b013e31817fa489
NR 25
TC 56
Z9 60
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 2163-0755
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD JAN
PY 2012
VL 72
IS 1
BP 235
EP 241
DI 10.1097/TA.0b013e318236b319
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Surgery
GA 898IF
UT WOS:000300734800043
PM 22310132
DA 2026-07-24
ER

PT J
AU Stone, PA
   Hass, SM
   Flaherty, SK
   DeLuca, JA
   Lucente, FC
   Kusminsky, RE
AF Stone, PA
   Hass, SM
   Flaherty, SK
   DeLuca, JA
   Lucente, FC
   Kusminsky, RE
TI Vacuum-assisted fascial closure for patients with abdominal trauma
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE abdominal compartment syndrome; open abdomen; vacuum closure; Bogota
   closure
ID PACK TECHNIQUE; WALL; PERITONITIS; EXPERIENCE; MANAGEMENT; RETENTION;
   PRESSURE; FAILURE; ABDOMEN; MARLEX
AB Background: Massive fluid resuscitation often is required for patients with intraabdominal trauma. Subsequently, fascial closure is not always possible in this subset of patients. Under these circumstances, an initial step can be the use of a temporary abdominal closure method. The authors currently use a vacuum-assisted closure to manage the open abdomen for some of their trauma patients. They present their experience over the past 3 years.
   Methods: From January 2000 to December 2002, 48 trauma patients were treated with temporary abdominal closure using a vacuum-assisted dressing. The ultimate management of the abdominal defect, the serum lactate levels measured in the emergency department, and the fluid balance at the last attempt to accomplish fascial closure were reviewed.
   Results: Delayed fascial closure was achieved in 23 (71.9%) of 32 patients who survived to discharge (26 of 48, 54.2%). Of the 32 patients who survived to discharge, 9 (28.1%) required an alternative closure, most often a split-thickness skin graft. Of the 16 patients who died before discharge, 8 died within 24 hours after admission. Whereas 5 of the 16 deaths occurred after delayed abdominal closure, 11 patients died without abdominal closure. Emergency department serum lactate levels above 8 mg/dL show a positive correlation with in-hospital mortality (6 of 16 patients; 38%; p = 0.001) and mortality within 24 hours of admission (6 of 8 patients; 75%; p = 0.003). Admission lactate levels were not associated with the type of closure achieved. However, primary closure was associated with a significant decrease in lactate levels during the first 12 hours. Complications included five abdominal abscesses, two enterocutaneous fistulas, and one split-thickness skin graft failure.
   Conclusion:. Patients requiring temporary abdominal closure have a significant in-hospital mortality rate of 33%. Delayed primary closure with vacuum assistance was achieved for 71.9% of the surviving patients. Maintaining a negative or total positive fluid balance of less than 20 L before the last attempted fascial closure improves successful closure rates, as seen in 19 of 22 patients (86.4%). The vacuum-assisted closure technique also enabled successful primary closure for two patients with extreme delay (>8 days). Elevated serum lactate levels are significantly correlated with early and in-hospital mortality. A significant decrease in lactate level during the first 12 hours is associated with achievement of primary closure.
C1 W Virginia Univ, CAMC Hlth Educ & Res Inst, Dept Surg, Sch Med, Charleston, WV 25304 USA.
C3 West Virginia University
RP Flaherty, SK (通讯作者)，W Virginia Univ, CAMC Hlth Educ & Res Inst, Dept Surg, Sch Med, 3211 MacCorkle Ave SE, Charleston, WV 25304 USA.
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NR 21
TC 95
Z9 109
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD NOV
PY 2004
VL 57
IS 5
BP 1082
EP 1086
DI 10.1097/01.TA.0000149248.02598.9E
PG 5
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 878QD
UT WOS:000225660600026
PM 15580036
DA 2026-07-24
ER

PT J
AU Keum, H
   Zhivov, EV
   Ortega-Loayza, AG
AF Keum, Heejo
   Zhivov, Elina V.
   Ortega-Loayza, Alex G.
TI Updates in innovation of the treatment of pyoderma gangrenosum
SO EXPERT REVIEW OF CLINICAL PHARMACOLOGY
LA English
DT Review
DE Pyoderma gangrenosum; treatment; wound care; pain management;
   spesolimab; vilobelimab; janus kinase inhibitor; negative pressure wound
   therapy
ID THERAPY
AB IntroductionPyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by rapidly enlarging, painful ulcers with undermined borders. The management of PG is challenging due to the lack of standardized evidence-based treatments.Areas coveredThis review examines recent efforts to establish standardized outcomes for clinical trials to facilitate the drug development process for PG. It explores new therapeutics in development and evaluates advanced options for wound and pain management. Literature available on the pathogenesis, treatment, and pain management of PG from database inception to April 2024 was searched in PubMed, Embase, and Cochrane. ClinicalTrials.gov and the EU Clinical Trials Register were searched for clinical trials on PG.Expert opinionNew therapeutics such as interleukin 36 inhibitor and complement component C5a inhibitor more specifically target key pathways in the pathogenesis of PG have shown promise and can greatly benefit patients with PG, which still lacks an FDA-approved treatment. In addition to systemic therapy, local wound care and pain management should be carried out simultaneously to achieve successful wound healing.
C1 [Keum, Heejo] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA.
   [Zhivov, Elina V.] Univ Miami, Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL USA.
   [Ortega-Loayza, Alex G.] Oregon Hlth & Sci Univ, Dept Dermatol, 3303 SW Bond Ave CH 16D, Portland, OR 97239 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Miami; Oregon Health & Science University
RP Ortega-Loayza, AG (通讯作者)，Oregon Hlth & Sci Univ, Dept Dermatol, 3303 SW Bond Ave CH 16D, Portland, OR 97239 USA.
EM oretegalo@ohsu.edu
RI Loayza, Alex/AAN-3319-2020
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   Yildirim TD, 2024, RHEUMATOL INT, V44, P3009, DOI 10.1007/s00296-023-05418-y
NR 58
TC 5
Z9 5
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1751-2433
EI 1751-2441
J9 EXPERT REV CLIN PHAR
JI Expert Rev. Clin. Pharmacol.
PD FEB 1
PY 2025
VL 18
IS 1-2
BP 29
EP 39
DI 10.1080/17512433.2024.2447776
EA JAN 2025
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA X1W3W
UT WOS:001391137600001
PM 39720859
DA 2026-07-24
ER

PT J
AU Khansa, I
   Janis, JE
AF Khansa, I.
   Janis, J. E.
TI Management of skin and subcutaneous tissue in complex open abdominal
   wall reconstruction
SO HERNIA
LA English
DT Review
DE Abdominal wall reconstruction; Perforator preservation; Panniculectomy;
   Wound healing; Incisional negative pressure wound therapy; Progressive
   tension sutures
ID VENTRAL HERNIA REPAIR; PRESSURE WOUND THERAPY; PROGRESSIVE TENSION
   SUTURES; RANDOMIZED-CONTROLLED-TRIAL; OF-THE-LITERATURE; COMPONENTS
   SEPARATION; INCISION MANAGEMENT; VASCULAR-SURGERY; THIGH FLAP; DEFECTS
AB Open abdominal wall reconstruction is often a complex endeavor, usually performed on patients with multiple risk factors and co-morbidities.
   In this article, we review soft tissue management techniques that can optimize the skin and subcutaneous tissue, with the goal of reducing surgical-site occurrences.
   Regardless of the hernia repair technique used, outcomes can be highly dependent on the appropriate management of the skin and subcutaneous tissue. Indeed, dehiscence and surgical-site infection can jeopardize the entire reconstruction, especially in cases where synthetic mesh might become exposed and/or infected, setting up a "vicious cycle" (Holihan et al. in J Am Coll Surg 221:478-485, 2015).
   Multidisciplinary cooperation between the general and plastic surgeon is useful in cases of tenuous blood supply to the abdominal skin, in cases of redundant, marginal or excessive skin, and in cases of deficient skin.
C1 [Khansa, I.; Janis, J. E.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
C3 University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd, Columbus, OH 43212 USA.
EM jeffrey.janis@osumc.edu
RI ; Janis, Jeffrey/W-6760-2019
OI Khansa, Ibrahim/0000-0002-7978-6792; Janis, Jeffrey/0000-0001-6103-4798
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NR 52
TC 22
Z9 30
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2018
VL 22
IS 2
BP 293
EP 301
DI 10.1007/s10029-017-1662-3
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GA3SB
UT WOS:000428248700010
PM 28871371
DA 2026-07-24
ER

PT J
AU Schalamon, J
   Petnehazy, T
   Ainoedhofer, H
   Castellani, C
   Till, H
   Singer, G
AF Schalamon, Johannes
   Petnehazy, Thomas
   Ainoedhofer, Herwig
   Castellani, Christoph
   Till, Holger
   Singer, Georg
TI Experimental comparison of abdominal drainage systems
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal drainage; Experimental; Redon; Jackson; VAC
ID PERFORATED APPENDICITIS; APPENDECTOMY; CHILDREN
AB Background: In an experimental study the performance of different closed abdominal drainage systems was tested.
   Methods: A vacuum bottle designed for Redon Drainage, a flexible plastic bulb designed for Jackson-Pratt drains and a V.A.C.(R) Negative Pressure Wound Therapy System were used. In a porcine cadaveric study mimicking the abdominal cavity the intrinsic pressure (IP) at one and three minutes (T0, T3) and the amount of evacuated fluid were measured.
   Results: The Redon and Jackson drainage displayed a rapid decline to IP values of almost zero comparing T0 and T3. Only the V.A.C.(R) system was able to preserve constant values of negative IP values measured at both time points. Only the V.A.C.(R) system was able to remove almost the whole amount of inserted fluid.
   Conclusions: In an experimental setting the V.A.C.(R) system was superior to the other two tested systems in delivering constant negative IP and the amount of evacuated fluid. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Schalamon, Johannes; Petnehazy, Thomas; Ainoedhofer, Herwig; Castellani, Christoph; Till, Holger; Singer, Georg] Med Univ Graz, Dept Paediat & Adolescent Surg, Auenbruggerpl, Graz, Austria.
C3 Medical University of Graz
RP Singer, G (通讯作者)，Med Univ Graz, Dept Paediat & Adolescent Surg, Auenbruggerpl, Graz, Austria.
EM georg.singer@medunigraz.at
RI /B-2703-2010
OI Singer, Georg/0000-0003-4770-3144
CR Akkoyun I, 2012, J PEDIATR SURG, V47, P1886, DOI 10.1016/j.jpedsurg.2012.03.049
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NR 13
TC 2
Z9 2
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2017
VL 213
IS 6
BP 1038
EP 1041
DI 10.1016/j.amjsurg.2016.09.043
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EY4HW
UT WOS:000403939400008
PM 27765183
DA 2026-07-24
ER

PT J
AU Cebolla-Verdugo, M
   de Cádiz, VACG
   Velasco-Amador, JP
   Zulaika-Lloret, M
   Almazan-Fernández, FM
   Ruiz-Villaverde, R
AF Cebolla-Verdugo, Marta
   Cassini-Gomez de Cadiz, Victor Alfredo
   Velasco-Amador, Juan Pablo
   Zulaika-Lloret, Maria
   Almazan-Fernandez, Francisco Manuel
   Ruiz-Villaverde, Ricardo
TI Multidisciplinary Vulvar Cancer Management: The Dermatologist's
   Perspective
SO LIFE-BASEL
LA English
DT Review
DE vulvar cancer; squamous cell carcinoma (SCC); vulvar melanoma;
   dermatologist; radical vulvectomy; postoperative care; wound management;
   multidisciplinary approach; targeted therapies
ID SURGICAL-TREATMENT; RISK-FACTORS; INTRAEPITHELIAL NEOPLASIA; TARGETED
   THERAPY; MELANOMA; COMPLICATIONS; RECONSTRUCTION; CARCINOMA; SURGERY;
   LYMPHADENECTOMY
AB Vulvar cancer, particularly squamous cell carcinoma (SCC) and melanoma, poses significant diagnostic and therapeutic challenges due to its complex presentation and high rates of postoperative complications. Effective management requires a multidisciplinary approach, integrating the expertise of gynecologic oncologists, dermatologists, plastic surgeons, and other specialists. This review highlights the dermatologist's role in supporting early diagnosis, addressing predisposing conditions such as lichen sclerosus, and managing postoperative wound complications, including surgical site infections and dehiscence. Through two clinical cases, we illustrate how dermatological expertise complements surgical efforts by employing advanced wound care techniques such as negative pressure wound therapy and tailored dressing protocols. By collaborating closely with gynecologists and other team members, dermatologists enhance patient outcomes, ensuring timely recovery and the prevention of long-term sequelae. The article also discusses recent advances in treatment guidelines and targeted therapies, underscoring the importance of integrated care for optimizing patient outcomes in vulvar cancer.
C1 [Cebolla-Verdugo, Marta; Cassini-Gomez de Cadiz, Victor Alfredo; Velasco-Amador, Juan Pablo; Zulaika-Lloret, Maria; Almazan-Fernandez, Francisco Manuel; Ruiz-Villaverde, Ricardo] Hosp Univ San Cecilio, Dept Dermatol, Ave Conocimiento S-N, Granada 18016, Spain.
   [Cebolla-Verdugo, Marta; Cassini-Gomez de Cadiz, Victor Alfredo; Velasco-Amador, Juan Pablo; Zulaika-Lloret, Maria; Almazan-Fernandez, Francisco Manuel; Ruiz-Villaverde, Ricardo] Inst Biosanitario Granada, Ibs, Granada 18012, Spain.
C3 Hospital Universitario San Cecilio; Instituto de Investigacion
   Biosanitaria IBS Granada
RP Cebolla-Verdugo, M (通讯作者)，Hosp Univ San Cecilio, Dept Dermatol, Ave Conocimiento S-N, Granada 18016, Spain.; Cebolla-Verdugo, M (通讯作者)，Inst Biosanitario Granada, Ibs, Granada 18012, Spain.
EM martacevers@gmail.com; elromeral28a@gmail.com; pablova.correo@gmail.com;
   zulaikalloretmaria@gmail.com; almazanweb@gmail.com;
   ismenios2005@gmail.com
RI ; Cebolla Verdugo, Marta/JHS-4101-2023; Ruiz-Villaverde,
   Ricardo/F-5007-2016
OI Zulaika Lloret, María/0009-0008-5865-410X; Cebolla Verdugo,
   Marta/0000-0001-7519-205X; Ruiz-Villaverde, Ricardo/0000-0002-0381-6174
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NR 58
TC 3
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JAN
PY 2025
VL 15
IS 1
AR 19
DI 10.3390/life15010019
PG 13
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA T6H3W
UT WOS:001405987300001
PM 39859956
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Coccolini, F
   Biffl, W
   Catena, F
   Ceresoli, M
   Chiara, O
   Cimbanassi, S
   Fattori, L
   Leppaniemi, A
   Manfredi, R
   Montori, G
   Pesenti, G
   Sugrue, M
   Ansaloni, L
AF Coccolini, Federico
   Biffl, Walter
   Catena, Fausto
   Ceresoli, Marco
   Chiara, Osvaldo
   Cimbanassi, Stefania
   Fattori, Luca
   Leppaniemi, Ari
   Manfredi, Roberto
   Montori, Giulia
   Pesenti, Giovanni
   Sugrue, Michael
   Ansaloni, Luca
TI The open abdomen, indications, management and definitive closure
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Open abdomen; Peritonitis; Pancreatitis; Trauma; Management; Closure
ID ABDOMINAL COMPARTMENT SYNDROME; INFECTED PANCREATIC NECROSIS;
   NEGATIVE-PRESSURE THERAPY; INTRAABDOMINAL HYPERTENSION; TEMPORARY
   CLOSURE; FASCIAL CLOSURE; BIOLOGIC MESHES; WOUND THERAPY; EXPERIENCE;
   OUTCOMES
AB The indications for Open Abdomen (OA) are generally all those situations in which is ongoing the development an intra-abdominal hypertension condition (IAH), in order to prevent the development of abdominal compartmental syndrome (ACS). In fact all those involved in care of a critically ill patient should in the first instance think how to prevent IAH and ACS. In case of ACS goal directed therapy to achieve early opening and early closure is the key: paradigm of closure shifts to combination of therapies including negative pressure wound therapy and dynamic closure, in order to reduce complications and avoid incisional hernia.
   There have been huge studies and progress in survival of critically ill trauma and septic surgical patients: this in part has been through the great work of pioneers, scientific societies and their guidelines; however future studies and continued innovation are needed to better understand optimal treatment strategies and to define more clearly the indications, because OA by itself is still a morbid procedure.
C1 [Coccolini, Federico; Ceresoli, Marco; Manfredi, Roberto; Montori, Giulia; Ansaloni, Luca] Papa Giovanni XXIII Hosp, Dept Gen Surg, I-24127 Bergamo, Italy.
   [Biffl, Walter] Denver Hlth Med Ctr, Denver, CO USA.
   [Catena, Fausto] Osped Maggiore Parma, Dept Gen Surg, Parma, Italy.
   [Chiara, Osvaldo; Cimbanassi, Stefania] Osped Niguarda Ca Granda, Niguarda Trauma Ctr, Milan, Italy.
   [Fattori, Luca; Pesenti, Giovanni] Azienda Osped San Gerardo, Unita Operat Chirurg Urgenza, Monza, Italy.
   [Leppaniemi, Ari] Univ Helsinki, Dept Abdominal Surg, Helsinki, Finland.
   [Sugrue, Michael] Letterkenny Hosp, Donegal, Ireland.
   [Sugrue, Michael] Donegal Clin Res Acad, Donegal, Ireland.
   [Sugrue, Michael] Univ Coll Hosp, Galway, Ireland.
C3 ASST Papa Giovanni XXIII; Denver Health Medical Center; University of
   Parma; University Hospital of Parma; Ospedale Niguarda Ca' Granda; IRCCS
   Ca Granda Ospedale Maggiore Policlinico; University of Helsinki;
   Ollscoil na Gaillimhe-University of Galway
RP Coccolini, F (通讯作者)，Papa Giovanni XXIII Hosp, Dept Gen Surg, Piazza OMS 1, I-24127 Bergamo, Italy.
EM federico.coccolini@gmail.com
RI Leppäniemi, Ari/GQZ-7991-2022; chiara, osvaldo/R-6151-2018; Coccolini,
   Federico/AAJ-6507-2020; Montori, Giulia/ABF-9661-2020; Ansaloni,
   Luca/AAP-9134-2020; Gunardi, Triana/MGT-0616-2025; Ansaloni,
   Luca/AAJ-6507-2020; Ceresoli, Marco/GMW-5356-2022
OI chiara, osvaldo/0000-0003-2409-2109; Coccolini,
   Federico/0000-0001-6364-4186; Montori, Giulia/0000-0002-7649-2174;
   Ansaloni, Luca/0000-0001-6427-0307; Ansaloni, Luca/0000-0001-6427-0307;
   Ceresoli, Marco/0000-0001-7935-3842
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NR 71
TC 90
Z9 116
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUL 25
PY 2015
VL 10
AR 32
DI 10.1186/s13017-015-0026-5
PG 10
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA CN4MK
UT WOS:000358404000001
PM 26213565
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Siegel, HJ
   Herrera, DF
   Gay, J
AF Siegel, Herrick J.
   Herrera, Diego F.
   Gay, Jason
TI Silver Negative Pressure Dressing With Vacuum-assisted Closure of
   Massive Pelvic and Extremity Wounds
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID COMPLICATIONS; INFECTIONS; MANAGEMENT; BACTERIA; EFFICACY; FUSION;
   TUMORS
AB Massive soft tissue loss involving the pelvis and extremities from trauma, infections, and tumors remains a challenging and debilitating problem. Although vacuum-assisted closure (VAC) technology is effective in the management of soft tissue loss, the adjunct of a silver dressing in the setting of massive wounds has not been as well tested.
   Does a silver negative pressure dressing used in conjunction with a wound VAC decrease (1) the length of acute hospital stay and overall length of treatment; (2) the number of surgical d,bridements the patients underwent as part of their care; and (3) the likelihood of wound closure without soft tissue transposition?
   We evaluated 42 patients with massive (> 200 cm(2)) pelvic and extremity wounds from trauma, infection, or tumor who were treated with the wound VAC with or without a silver negative pressure dressing between January 2003 and January 2010; the first 26 patients were treated with the wound VAC alone, and in the final 16 consecutively treated patients, the silver dressing was added to the regimen. We reviewed medical records to determine length of treatment as well as the number and type of surgical interventions these patients underwent. We compared the group treated with the wound VAC alone with those patients treated with the wound VAC and silver negative pressure dressing.
   Hospital stay averaged 19 days in the VAC only group and 7.5 days in the VAC with silver dressing group (p < 0.041), length of overall treatment averaged 33 days in the VAC only group and 14.3 days in the VAC with silver dressing group (p < 0.022), number of operative d,bridements averaged 7.9 in the VAC alone group and 4.1 in the VAC with silver dressing group (p < 0.001), and success of wound closure without soft tissue transposition was 16 of 26 patients in the VAC alone group and three of 16 patients in the VAC with silver dressing group (p < 0.033).
   Based on the reduced length of care and the number of surgical procedures these patients with massive wounds of the pelvis and extremities underwent, we now use the silver negative pressure dressing in combination with the wound VAC as part of routine care of such patients. These results may be used as hypothesis-generating data for future randomized studies.
   Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
C1 [Siegel, Herrick J.; Herrera, Diego F.] UAB, Sch Med, Dept Surg, Birmingham, AL 35305 USA.
   [Gay, Jason] UAB, Med Ctr, Orthopaed RNFA, Birmingham, AL 35305 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Siegel, HJ (通讯作者)，UAB, Sch Med, Dept Surg, Birmingham, AL 35305 USA.
EM hsiegel@uabmc.edu
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NR 33
TC 11
Z9 19
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD MAR
PY 2014
VL 472
IS 3
BP 830
EP 835
DI 10.1007/s11999-013-3123-3
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AA3ET
UT WOS:000330976400011
PM 23813240
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Saziye, K
   Cikirikcioglu, M
   Ilker, U
   Afksendyios, K
AF Saziye, Karaca
   Cikirikcioglu, Mustafa
   Ilker, Uckay
   Afksendyios, Kalangos
TI Comparison of vacuum-assisted closure device and conservative treatment
   for fasciotomy wound healing in ischaemia-reperfusion syndrome:
   preliminary results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Compartment syndrome; Fasciotomy closure; Fasciotomy treatment; VAC;
   Vascular surgery
ID NEGATIVE-PRESSURE; DIABETIC FOOT; MANAGEMENT; THERAPY; PROMOTE; TRIAL;
   RISK; SKIN
AB Ischaemia-reperfusion syndrome (IRS) is a condition that may require early fasciotomy. In the past, fasciotomies ultimately required prolonged hospitalisation. Vacuum-assisted closure (VAC) therapy system is an innovative method which promotes wound healing by reducing wound oedema, increasing microcirculation, and stimulation of granulation tissue. The aim of this retrospective study was to compare the VAC treatment with the conservative treatment of the fasciotomy wound until definitive surgical closure. The researchers retrospectively identified 15 patients, 3 females and 12 males, with a mean age of 69 years, who underwent a fasciotomy between January 2003 and December 2009 at the University Hospital of Geneva. All of the fasciotomies performed on the patients were on account of IRS. Seven patients were subjected to wound treatment using the VAC-system device and eight patients underwent treatment through the usual conservative method. The data were analysed by comparing the operative wound size, length of time for wound closure and duration of hospital stay in both groups. The number of days after fasciotomy until surgical wound closure in the VAC-system group (n = 7) ranged from 8 to 13 days with a mean of 11 days. The wound size at the day of closure was decreased in length by a mean of 58% (range 29-67%) and in diameter by a mean of 56% (range 33-75%). The duration of hospital stay for this group ranged from 12 to 18 days with a mean of 14 days. No signs of infections were observed and no re-operation was required after first closure. In the conservative group (n = 8), the time to wound closure ranged between 12 and 20 days with a mean of 15 days. The wound size was decreased in length by a mean of 40% (range 32-53%) and in diameter by a mean 46% (range 30-70%). The mean duration of hospital stay was 18 center dot 5 days. Three of the patients in the conservative treatment group manifested wound infection during the course of the treatment. VAC device could be a new standard for treatment of fasciotomy wound. VAC therapy is a recent innovation and becoming more and more a necessary complementary therapy to hasten wound healing. In our preliminary study, the VAC-system device showed significantly reduction of the wound size, decreased tissue oedema, duration of hospital days and improvement of granulation tissue.
C1 [Saziye, Karaca; Cikirikcioglu, Mustafa; Afksendyios, Kalangos] Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Ilker, Uckay] Univ Hosp Geneva, Dept Infectiol, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva; University of Geneva
RP Saziye, K (通讯作者)，Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM saziye.karaca@hcuge.ch
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   2000, WOUND CARE, V32, P13
NR 38
TC 30
Z9 37
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2011
VL 8
IS 3
BP 229
EP 236
DI 10.1111/j.1742-481X.2011.00773.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 762OI
UT WOS:000290488900005
PM 21401883
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Chen, GW
   Lan, XX
   Li, F
   Zeng, DY
   Wang, LH
   Chen, XY
   Zhu, L
AF Chen, Guowei
   Lan, Xiaoxu
   Li, Fang
   Zeng, Deyuan
   Wang, Luhong
   Chen, Xiaoyu
   Zhu, Li
TI Peristomal pyoderma gangrenosum: a review of nursing research progress
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE immunosuppressive treatment; negative pressure wound therapy; ostomy
   complications; peristomal pyoderma gangrenosum; wound nursing
ID MANAGEMENT; DIAGNOSIS; DISEASE
AB Peristomal pyoderma gangrenosum (PPG) is a rare and therapeutically challenging inflammatory dermatosis predominantly affecting individuals with stoma surgery. This review provides a comprehensive overview of PPG, encompassing its etiology, clinical manifestations, diagnostic methods, treatment strategies, and nursing management. PPG's multifactorial etiology involves immune dysfunction, genetic predisposition, surgical trauma, and demographic factors, which contribute to the formation of painful ulcers that significantly impair patients' quality of life. Accurate diagnosis requires a multidisciplinary approach, including clinical evaluation, histopathological examination, and advanced diagnostic criteria. Effective management combines local wound care, systemic therapies, and surgical interventions, emphasizing a patient-centered and evidence-based approach. Nursing strategies, including advanced wound care, pain management, psychological support, nutritional interventions, and health education, play a vital role in optimizing outcomes and preventing recurrence. Future research should focus on the development of specific biomarkers, novel therapeutic agents, and standardized nursing protocols to address the unmet needs in PPG care. This integrated diagnostic, therapeutic, and nursing framework aims to enhance patient outcomes and provide insights for future clinical and research advancements.
C1 [Chen, Guowei; Li, Fang; Zeng, Deyuan; Wang, Luhong; Zhu, Li] Chongqing Gen Hosp, Dept Gen Surg, Chongqing, Peoples R China.
   [Lan, Xiaoxu] Chongqing Gen Hosp, Dept Hemodialysis, Chongqing, Peoples R China.
   [Chen, Xiaoyu] Xipeng Town Hlth Ctr, Dept Nursing, Chongqing, Peoples R China.
RP Zhu, L (通讯作者)，Chongqing Gen Hosp, Dept Gen Surg, Chongqing, Peoples R China.
EM 709522592@qq.com
RI zeng, deyuan/KTI-7517-2024
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 16
PY 2026
VL 13
AR 1774931
DI 10.3389/fmed.2026.1774931
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FV6ZQ
UT WOS:001728508100001
PM 41919168
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Huang, JJ
   Ren, HJ
   Jiang, YG
   Wu, XW
   Ren, JN
AF Huang, Jinjian
   Ren, Huajian
   Jiang, Yungang
   Wu, Xiuwen
   Ren, Jianan
TI Technique Advances in Enteroatmospheric Fistula Isolation After Open
   Abdomen: A Review and Outlook
SO FRONTIERS IN SURGERY
LA English
DT Review
DE open abdomen; enteroatmospheric fistula; fistula isolation; biomedical
   device; 3D printing
AB Enteroatmospheric fistula (EAF) after open abdomen adds difficulties to the management and increases the morbidity and mortality of patients. As an effective measurement, reconstructing gastrointestinal tract integrity not only reduces digestive juice wasting and wound contamination, but also allows expedient restoration of enteral nutrition and intestinal homeostasis. In this review, we introduce several technologies for the temporary isolation of EAF, including negative pressure wound therapy, fistuloclysis, fistula patch, surgical covered stent, three-dimensional (3D) printing stent, and injection molding stent. The manufacture and implantation procedures of each technique with their pros and cons are described in detail. Moreover, the approach in combination with finger measurement, x-ray imaging, and computerized tomography is used to measure anatomic parameters of fistula and design appropriate 3D printer-recognizable stereolithography files for production of isolation devices. Given the active roles that engineers playing in the technology development, we call on the cooperation between clinicians and engineers and the organization of clinical trials on these techniques.
C1 [Huang, Jinjian; Ren, Huajian; Jiang, Yungang; Wu, Xiuwen; Ren, Jianan] Southeast Univ, Sch Med, Jinling Hosp, Res Inst Gen Surg, Nanjing, Peoples R China.
C3 Southeast University - China
RP Wu, XW; Ren, JN (通讯作者)，Southeast Univ, Sch Med, Jinling Hosp, Res Inst Gen Surg, Nanjing, Peoples R China.
EM lygwxw@163.com; jiananr@gmail.com
OI Wu, Xiuwen/0000-0002-3813-3867; Huang, Jinjian/0000-0002-8951-8935
FU National Major Scientific and Technological Special Project for
   Significant New Drugs Development [2018ZX09J18111-04]; General Project
   of Military Logistics Research [CLB19J025]; Innovation Project of
   Military Medicine [16CXZ007]; Distinguished Scholars Foundation of
   Jiangsu Province [JCRCB2016006]; Postgraduate Research & Practice
   Innovation Program of Jiangsu Province [KYCX20_0150]
FX We thank to Yanhan Ren in Rosalind Franklin University of Medicine and
   Science, USA for his help in language editing. We also appreciate the
   financial supports from the National Major Scientific and Technological
   Special Project for Significant New Drugs Development
   (2018ZX09J18111-04), General Project of Military Logistics Research
   (CLB19J025), Innovation Project of Military Medicine (16CXZ007),
   Distinguished Scholars Foundation of Jiangsu Province (JCRCB2016006),
   and Postgraduate Research & Practice Innovation Program of Jiangsu
   Province (KYCX20_0150).
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NR 48
TC 10
Z9 19
U1 1
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JAN 20
PY 2021
VL 7
AR 559443
DI 10.3389/fsurg.2020.559443
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QB4DM
UT WOS:000614090900001
PM 33553237
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Felsenreich, DM
   Gachabayov, M
   Ritter, E
   Bergamaschi, R
AF Felsenreich, Daniel Moritz
   Gachabayov, Mahir
   Ritter, Edmond
   Bergamaschi, Roberto
TI En-bloc excision of sacral squamous cell carcinoma with immediate
   reconstruction
SO UPDATES IN SURGERY
LA English
DT Article; Early Access
DE Abdomino-perineal excision of rectum; Distal sacrectomy; Pilonidal cyst;
   Squamous cell carcinoma; Vertical rectus abdominis myocutaneous flap
ID PRESSURE ULCER; WOUNDS
AB Sacral squamous cell carcinoma is an uncommon condition that may arise in scars following burns or in chronic wounds, such as an untreated pilonidal cyst. The aim of the present technical note is to describe a surgical technique aimed at minimizing local recurrence rates by en-bloc resection as well as providing immediate plastic reconstruction: 1. right-sided extended vertical rectus abdominis myo-cutaneous (VRAM) flap; 2. abdomino-perineal excision of the rectum with end colostomy; 3. en-bloc excision of the mass inclusive of gluteus maximus muscles and distal sacrectomy; 4. sacrectomy defect covered with VRAM flap; 5. bilateral gluteal defects covered with single-layer dermal substitute of bovine collagen and elastin hydrolysate followed by immediate split-thickness skin grafting from bilateral thigh donor sites, and negative pressure wound therapy dressings. This approach resulted in a favorable outcome at 2-year follow-up in a male patient presenting with a large locally advanced sacral squamous cell carcinoma involving the external anal sphincter muscle.
C1 [Felsenreich, Daniel Moritz; Gachabayov, Mahir; Bergamaschi, Roberto] New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Colorectal Surg, Valhalla, NY 10595 USA.
   [Ritter, Edmond] New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Plast Surg, Valhalla, NY USA.
   [Bergamaschi, Roberto] New York City Hlth Hosp, Jacobi Med Ctr, Dept Surg, Suite 610, 1400 Pelham Pkwy South, New York, NY 10461 USA.
C3 Westchester Medical Center; New York Medical College; New York Medical
   College; Westchester Medical Center; Jacobi Medical Center
RP Bergamaschi, R (通讯作者)，New York Med Coll, Westchester Med Ctr, Dept Surg, Sect Colorectal Surg, Valhalla, NY 10595 USA.; Bergamaschi, R (通讯作者)，New York City Hlth Hosp, Jacobi Med Ctr, Dept Surg, Suite 610, 1400 Pelham Pkwy South, New York, NY 10461 USA.
EM rcmbergamaschi@gmail.com
RI Bergamaschi, Roberto/I-1984-2015; Gachabayov, Mahir/M-2659-2015
OI Bergamaschi, Roberto/0000-0001-9993-0563; 
CR Choa R, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3997
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NR 14
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD 2024 APR 30
PY 2024
DI 10.1007/s13304-024-01861-z
EA APR 2024
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RX8I3
UT WOS:001231044300002
PM 38691330
DA 2026-07-24
ER

PT J
AU Timmons, J
   Russell, F
AF Timmons, John
   Russell, Fiona
TI The use of negative-pressure wound therapy to manage enteroatmospheric
   fistulae in two patients with large abdominal wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Enteroatmospheric fistulae; Fistulae; Negative pressure; Open abdomen
ID INTRAABDOMINAL HYPERTENSION; COMPARTMENT SYNDROME; CLOSURE
AB Enteric fistulae are a relatively common complication of bowel surgery or in surgery where the bowel has been exposed. Fistulae can present a significant threat to patients' well-being. Changes in surgical techniques and in particular the rise in damage control surgery for emergency patients have led to an increase in open abdominal wounds. The presence of an enteroatmospheric fistula on the surface of a wound can cause a number of distressing symptoms/issues for the patient whilst providing a significant challenge for the clinician. The loss of fluid, proteins and electrolytes will place the patient in danger of becoming hypokalaemic and malnourished. A variety of techniques are available, most refer to a method of isolating the fistula using stoma rings or washers and ostomy paste. The role of negative pressure in the management of wounds with fistula is in its infancy; however, there is evidence to suggest that isolation techniques can be advantageous in managing wounds with fistulae.
C1 [Timmons, John] Smith & Nephew Healthcare, Wound Care, Kingston Upon Hull, Yorks, England.
   [Timmons, John; Russell, Fiona] Aberdeen Royal Infirm, Dept Tissue Viabil, Aberdeen, Scotland.
C3 Smith & Nephew; University of Aberdeen
RP Timmons, J (通讯作者)，Smith & Nephew Healthcare, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM john.timmons@smith-nephew.com
CR Al-Khoury G, 2008, J AM COLL SURGEONS, V206, P397, DOI 10.1016/j.jamcollsurg.2007.07.027
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
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NR 11
TC 11
Z9 12
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2014
VL 11
IS 6
BP 723
EP 729
DI 10.1111/iwj.12038
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AU3JS
UT WOS:000345509700025
PM 23490208
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Chen, BX
   Ke, CN
   Zou, SY
   Liu, Y
   Chen, DS
   Liu, YM
   Xu, S
AF Chen, Binxiong
   Ke, Changneng
   Zou, Songyun
   Liu, Yang
   Chen, Dengshan
   Liu, Yueming
   Xu, Shi
TI The therapeutic effect of concentrated growth factor gel on skin wounds
   with bone or tendon exposure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE concentrated growth factor; refractory wounds; soft tissue wounds;
   wound; wound care; wound dressing; wound healing
ID ARTIFICIAL DERMIS
AB Treatment of soft tissue wounds with bone or tendon exposure remains a tough clinical challenge for surgeons. The current clinical approaches include various types of flap reconstruction and artificial dermis grafting as well as negative pressure wound therapy (NPWT), which are time-consuming and often result in graft failure or significant scarring. Concentrated growth factor (CGF) is a novel blood extract that contains many growth factors, platelets and fibrin to promote an orderly healing process. However, few reports have focused on wounds with bone or tendon exposure. We present a limited series and two specific cases of skin wound with bone or tendon exposed that received surgical debridement followed by CGF treatment. CGF appeared to facilitate wound closure effectively and also reduced scar formation. Our findings provide a novel therapeutic option for refractory wounds with bone or tendon exposure. Declaration of interest: The authors have no conflicts of interest to declare.
C1 [Chen, Binxiong; Ke, Changneng; Zou, Songyun; Liu, Yang; Liu, Yueming; Xu, Shi] Shenzhen Longhua Dist Cent Hosp, Dept Burn & Plast Surg, Shenzhen, Guangdong, Peoples R China.
   [Chen, Dengshan] Fuyong Peoples Hosp Baoan Dist, Tangwei Community Healthcare Ctr, Shenzhen, Guangdong, Peoples R China.
C3 Shenzhen Longhua District Central Hospital
RP Xu, S (通讯作者)，Shenzhen Longhua Dist Cent Hosp, Dept Burn & Plast Surg, Shenzhen, Guangdong, Peoples R China.
EM xushi_cn@163.com
FU Scientific Research Projects of Medical and Health Institutions of
   Longhua District, Shenzhen [2021001, 2021005, 2022015]; Social Public
   Research Projects of Shenzhen Longhua District [LHQJCYJ202102]; Regional
   Joint Fund of Guangdong Province [2021A1515111063]
FX Acknowledgements This research was supported by the Scientific Research
   Projects of Medical and Health Institutions of Longhua District,
   Shenzhen (Grant Nos. 2021001, 2021005 and 2022015) , the Social Public
   Research Projects of Shenzhen Longhua District (Grant No. LHQJCYJ202102)
   , and Regional Joint Fund of Guangdong Province (Grant No.
   2021A1515111063) .
CR Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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NR 17
TC 0
Z9 0
U1 1
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2024
VL 33
SU 2A
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LN3E9
UT WOS:001187436200004
DA 2026-07-24
ER

PT J
AU Saijo, H
   Kilpadi, DV
   Akita, S
AF Saijo, Hiroto
   Kilpadi, Deepak V.
   Akita, Sadanori
TI Evaluation of the use of recombinant human basic fibroblast growth
   factor in combination with negative pressure wound therapy with
   instillation and dwell time in porcine full-thickness wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID AUTOLOGOUS BONE-MARROW; SALINE INSTILLATION; CELLS
AB NPWT with instillation and dwell time (NPWTi-d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh-bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi-d and rh-bFGF. Six pigs received 12 full-thickness excisional skin wounds and were treated with six different treatment groups for each pair. The treatment regimens were composed NPWTi-d, NPWT, or advanced wound care with or without rh-bFGF. On day 6, the minimum granulation tissue thickness and blood vessel number of the group of combined treatment with NPWTi-d and rh-bFGF spray were significantly greater than that of the control group. Combined treatment with NPWTi-d and rh-bFGF spray reads to good granulation tissue formation and vascularization for accelerating wound healing.
C1 [Saijo, Hiroto] Nagasaki Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, Nagasaki, Japan.
   [Kilpadi, Deepak V.] Kinet Concepts Inc, Act Healing Solut Appl Sci, San Antonio, TX USA.
   [Akita, Sadanori] Fukuoka Univ, Sch Med, Dept Plast Surg Wound Repair & Regenerat, Fukuoka, Japan.
C3 Nagasaki University; Fukuoka University
RP Akita, S (通讯作者)，Fukuoka Univ, Sch Med, Dept Plast Surg Wound Repair & Regenerat, Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan.
EM akitas@fukuoka-u.ac.jp
RI Saijo, Hiroto/AAC-4030-2020; akita, sadanori/Y-6838-2019
OI Saijo, Hiroto/0000-0003-3646-0263; akita, sadanori/0000-0001-8225-9363
FU KCI
FX This study was supported by KCI. Dr. Kilpadi is employed by KCI, H27-10.
CR Akela A, 2012, INT WOUND J, V9, P505, DOI 10.1111/j.1742-481X.2011.00909.x
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NR 15
TC 6
Z9 6
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2017
VL 25
IS 6
BP 972
EP 975
DI 10.1111/wrr.12609
PG 4
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA FZ4ZY
UT WOS:000427602100007
PM 29328528
DA 2026-07-24
ER

PT J
AU Olivia, G
   Petter, L
   Håkan, P
AF Olivia, Grip
   Petter, Lindahl
   Hakan, Parsson
TI Acute Compartment Syndrome Following Thrombolysis For Acute Lower Limb
   Ischemia
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID FASCIOTOMY; DIAGNOSIS; VALIDATION; MANAGEMENT; ARTERIAL; ANEURYSM;
   REGISTRY; SURGERY; LEG
AB Background: Acute Compartment syndrome (ACS) with subsequent need for fasciotomy is a serious and insidious complication after revascularization for acute lower limb ischemia (ALI). The development of ACS during endovascular catheter directed thrombolysis is particularly difficult to identify. The aim was to identify the incidence, predisposing factors, wound treatment, and outcome in terms of amputation and survival for patients presenting with ALI that develop ACS during catheter directed thrombolysis. Patients who did not develop ACS after thrombolysis were analyzed as controls. Methods: Descriptive retrospective analysis of prospective databases from two large tertiaryreferral vascular centers. Patients with ACS after thrombolysis for ALI between 2001-2017 were analyzed. Results: Seventy-eight cases and 621 controls were identified. Mean age was 72 years and 30 (38.5%) were women in the ACS group. Patients that developed ACS presented with significantly more severe preoperative ischemia. With 38.5% having Rutherford 2b classification as compared to 22.7 % in the control group ( P = 0.002). Occluded popliteal arter y aneur ysms were also associated with a higher incidence of ACS ( P = 0.041). Treatment of the fasciotomy wound was most commonly treated with regular wound dressing in 45 (58%) of cases, while wound dressing and foot pump and vacuum assisted closure were used in 14 (18%) and 19 (24%) respectively. These differing approaches did not affect the number of wound infections and amputations, which was similar regardless of treatment type. Vacuum assisted closure was associated with a higher degree of skin graft closure ( P = 0.001). The median time to complete wound closure was 10 days. One year after thrombolysis, the major amputation rate in the ACS group was 31% as opposed to 17% in control group, P = 0.003. Mortality measured at 16.7% and 15.3%, respectively, P = 0.872. Amputation-free survival in the ACS group was 62% vs. 73% in the control group, P = 0.035. These differences level out, however, when applying long-term analysis of amputationfree survival in Kaplan-Meier analysis (log-rank 0.103). Conclusions: Patients that developed ACS during endovascular CDT presented with a more severe pre-operative ischemia, more occluded popliteal arter y aneur ysms and had a higher amputation rate during the first year, compared to controls. The development of ACS during endovascular treatment of ALI with thrombolysis is not uncommon and warrants both clinical awareness and rapid treatment.
C1 [Olivia, Grip] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, Uppsala, Sweden.
   [Petter, Lindahl] Lund Univ, Dept Clin Sci, Fac Med, Lund, Sweden.
   [Hakan, Parsson] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
C3 Uppsala University; Lund University; Linkoping University
RP Håkan, P (通讯作者)，Linkoping Univ, Dept Biomed & Clin Sci, Kalmar Hosp, S-39185 Linkoping, Sweden.
EM hakan.parsson@liu.se
OI pärsson, håkan/0000-0002-6566-8381
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NR 36
TC 13
Z9 14
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2022
VL 79
BP 182
EP 190
DI 10.1016/j.avsg.2021.07.015
EA FEB 2022
PG 9
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA YV1FT
UT WOS:000752478600024
PM 34644632
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Rocchi, R
   Hibner-Szaltys, M
   Hallowell, G
   Marcatili, M
AF Rocchi, R.
   Hibner-Szaltys, M.
   Hallowell, G.
   Marcatili, M.
TI Treatment of an abdominal wound with puncture of the left ventral colon
   in a gelding
SO EQUINE VETERINARY EDUCATION
LA English
DT Article; Early Access
DE horse; abdomen; celiotomy; penetrating trauma; peritonitis; wound
ID HORSES; COMPLICATIONS; MANAGEMENT; LAVAGE
AB This report details the treatment of an abdominal wound with puncture of the large intestine and associated complications in an adult horse. The wound was located over the left eleventh costochondral junction. The gelding was referred to the hospital 48 h after the initial injury and presented with pyrexia and dullness. Septic peritonitis was confirmed by abdominocentesis. During exploratory celiotomy, a puncture of the left ventral colon with minimal abdominal contamination was identified. The edges of the penetration site in the left ventral colon were excised, the defect closed in two layers and the abdomen was lavaged. During the post-operative period, the horse showed further signs of septic peritonitis. This was treated with abdominal lavage under standing sedation. Other complications included fever and surgical site infection of the celiotomy incision. The latter was treated with systemic antimicrobials and negative pressure wound therapy. The horse was discharged 12 weeks after surgery and no long-term complications were reported up to 27 months post injury.
C1 [Rocchi, R.; Hibner-Szaltys, M.; Marcatili, M.] Pool House Equine Hosp, Lichfield, England.
   [Hallowell, G.] Med Vet Equine Referrals Ltd, Nottingham, England.
RP Rocchi, R (通讯作者)，Pool House Equine Hosp, Lichfield, England.
EM roberta.rocchi@poolhousevets.co.uk
RI Hallowell, Gayle/A-9965-2018
CR Akasaka H, 2023, JCI INSIGHT, V8, DOI 10.1172/jci.insight.167336
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0957-7734
EI 2042-3292
J9 EQUINE VET EDUC
JI Equine Vet. Educ.
PD 2026 APR 13
PY 2026
DI 10.1111/eve.70111
EA APR 2026
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GL4DH
UT WOS:001739173100001
DA 2026-07-24
ER

PT J
AU Li, JH
   Chang, ZQ
AF Li, Jianhua
   Chang, Zhengqi
TI Case Report: A spinal infection with bilateral psoas abscesses was
   treated with NPWT to enhance the local infection by increasing the
   infiltration of neutrophil cells and draining the pus
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE neutrophil; spinal infections; bilateral psoas abscess; lateral
   approach; negative pressure wound therapy (NPWT)
ID POSTERIOR DEBRIDEMENT; INSTRUMENTATION; MANAGEMENT; DRAINAGE; THERAPY
AB Treatment of spinal brucellosis with bilateral psoas abscess is a challenging clinical endeavor. We retrospectively evaluated a case of lumbar infection and bilateral psoas abscess, and was effectively managed through a unilateral extreme lateral approach with the aid of NPWT for bilateral drainage. We hypothesize that NPWT can influence the Piezo1 receptor of neutrophils and further influence the interaction between neutrophils and endothelial cells to promote the clearance of infected lesions, and this phenomenon is also observed in pathological slides. This proves that NPWT can rapidly enhance the recruitment of neutrophils in the infected area and improve the local immune response, and after a year of reassessment and tracking, Bilateral drainage using NPWT via a unilateral Extreme Lateral Approach could acquire satisfactory surgical outcomes, can be used as a treatment modality for lumbar infection with bilateral psoas abscesses.
C1 [Li, Jianhua; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Jinan, Peoples R China.
EM 26766771@qq.com
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NR 21
TC 5
Z9 6
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD AUG 4
PY 2023
VL 13
AR 1228376
DI 10.3389/fcimb.2023.1228376
PG 6
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA P3GS4
UT WOS:001049564900001
PM 37600941
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Montero, EC
   Jerónimo, LP
   Vazquez, AP
   Marín, LR
   Villarpando, PES
   Dobao, PD
AF Conde Montero, Elena
   Perez Jeronimo, Laura
   Peral Vazquez, Alicia
   Recarte Marin, Lorena
   Sanabria Villarpando, Pablo Ernesto
   de la Cueva Dobao, Pablo
TI Early and Sequential Punch Grafting in the Spectrum of Arteriolopathy
   Ulcers in the Elderly
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Martorell ulcer; pain; punch grafting; arteriolosclerosis; posttraumatic
ID LEG
AB Introduction. Posttraumatic ulcers secondary to age-related arteriolosclerosis may be included in the clinic-histopathological spectrum of the Martorell hypertensive ischemic ulcer. Histologically, they both present occlusive subcutaneous arteriolosclerosis. Considering these similarities, they could benefit from the same treatment. Case Report. The authors present an 84-year-old white female who had a painful 9-cm x 4-cm ulcer of the central inner aspect of her left leg. The ulcer had developed 2 months prior after mild trauma, with good response to early and sequential punch grafting, combined with single-use negative pressure wound therapy and compression therapy. Pain reduction was obtained from the first punch grafting session. To achieve complete epithelialization 16 weeks after the first punch grafting procedure, 2 more sessions were necessary. Conclusions. Early punch grafting is an effective technique for pain control and healing promotion in Martorell ulcers. Punch grafting, which may be performed in an outpatient setting, is well tolerated by patients and may be repeated several times if necessary.
C1 [Conde Montero, Elena; Perez Jeronimo, Laura; de la Cueva Dobao, Pablo] Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain.
   [Conde Montero, Elena; Perez Jeronimo, Laura; de la Cueva Dobao, Pablo] Hosp Virgen de la Torre, Madrid, Spain.
   [Peral Vazquez, Alicia; Recarte Marin, Lorena] Ctr Especialidades Vicente Soldevilla, Madrid, Spain.
   [Sanabria Villarpando, Pablo Ernesto] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina.
C3 Hospital Universitario Infanta Leonor; Hospital Universitario Infanta
   Leonor; Hospital Italiano de Buenos Aires; University of Buenos Aires;
   University of Buenos Aires Hospital
RP Montero, EC (通讯作者)，Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain.
EM elenacondemontero@gmail.com
CR Montero EC, 2018, WOUNDS, V30, pE9
   Fernández-Ginés FD, 2017, AM J HEALTH-SYST PH, V74, pE176, DOI 10.2146/ajhp151008
   Fourgeaud C, 2016, J Mal Vasc, V41, P329, DOI [10.1016/j.jmv.2016.08.002, 10.1016/j.jmv.2016.08.002]
   Muñoz SG, 2019, ACTAS DERMO-SIFILOGR, V110, P689, DOI 10.1016/j.ad.2018.06.016
   Haute Autorite de Sante, 2006, PRIS CHARG ULC JAMB
   Imbernón-Moya A, 2016, INT WOUND J, V13, P1060, DOI 10.1111/iwj.12474
   Isoherranen K, 2019, J WOUND CARE, V28, pS1, DOI 10.12968/jowc.2019.28.Sup6.S1
   Martinez Monsalve ARMJ, 2012, REV ELECT ANEST, V4, P181
   Monfort JB, 2018, DERMATOLOGY, V234, P194, DOI 10.1159/000492669
   Nordström A, 2008, ACTA DERM-VENEREOL, V88, P389, DOI 10.2340/00015555-0443
   Rock KL, 2008, ANNU REV PATHOL-MECH, V3, P99, DOI 10.1146/annurev.pathmechdis.3.121806.151456
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 12
TC 8
Z9 9
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2020
VL 32
IS 8
BP E38
EP E41
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6LH
UT WOS:000613554600001
PM 33166269
DA 2026-07-24
ER

PT J
AU Mikami, T
   Kaida, E
   Yabuki, Y
   Kitamura, S
   Kokubo, K
   Maegawa, J
AF Mikami, Taro
   Kaida, Eriko
   Yabuki, Yuichiro
   Kitamura, Sho
   Kokubo, Ken'ichi
   Maegawa, Jiro
TI Negative PressureWound Therapy Followed by Basic Fibroblast Growth
   Factor Spray as a Recovery Technique in Partial Necrosis of Distally
   Based Sural Flap for Calcaneal Osteomyelitis: A Case Report
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE calcaneal osteomyelitis; diabetic foot; flap necrosis
ID WOUND THERAPY; DIABETIC FOOT; QUALITY; CLOSURE; HEEL; RECONSTRUCTION;
   ULCERATIONS; AMPUTATION; FRACTURES; SALVAGE
AB The distally based sural flap is regarded as the first choice for reconstruction in the distal part of the lower leg because the flap is easy to raise, reliable in its blood supply, and prone to only a few complications. Limited data have investigated the details of treatment in cases of failure of distally based sural flaps. We report a case of calcaneal osteomyelitis in which a successful outcome was finally obtained with a partially necrosed, distally based sural flap using negative pressure wound therapy with basic fibroblast growth factor spray. The 2-year follow-up examination was uneventful. Moreover, the patient was able to walk freely with an ankle-foot orthosis in her house. This technique can be considered as a useful and effective option to recover unfavorable results of distally based sural flaps. (c) 2017 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Mikami, Taro; Kaida, Eriko; Kitamura, Sho; Kokubo, Ken'ichi] Fujisawa Shounandi Hosp, Dept Plast & Reconstruct Surg, Fujisawa, Kanagawa, Japan.
   [Mikami, Taro; Yabuki, Yuichiro; Maegawa, Jiro] Yokohama City Univ Med, Dept Plast & Reconstruct Surg, Yokohama, Kanagawa, Japan.
C3 Yokohama City University
RP Mikami, T (通讯作者)，Yokohama City Univ Med, Dept Plast & Reconstruct Surg, Kanazawa Ku, 236-004 Fukuura 3-9, Yokohama, Kanagawa, Japan.
EM zeong3@mac.com
OI Mikami, Taro/0000-0002-1381-2070
CR Akita S, 2005, BURNS, V31, P855, DOI 10.1016/j.burns.2005.04.008
   ANDERSON RB, 1990, FOOT ANKLE, V11, P168, DOI 10.1177/107110079001100307
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Attinger C, 2001, ORTHOP CLIN N AM, V32, P135, DOI 10.1016/S0030-5898(05)70199-1
   Baumhauer JF, 1998, FOOT ANKLE INT, V19, P849, DOI 10.1177/107110079801901210
   Bibbo C, 2012, J FOOT ANKLE SURG, V51, P375, DOI 10.1053/j.jfas.2011.12.001
   Boffeli TJ, 2013, J FOOT ANKLE SURG, V52, P107, DOI 10.1053/j.jfas.2012.06.018
   Bollinger M, 2002, FOOT ANKLE INT, V23, P927, DOI 10.1177/107110070202301007
   Chariker ME, 2009, PLAST RECONSTR SURG, V123, P1510, DOI 10.1097/PRS.0b013e3181a20563
   CRANDALL RC, 1981, J BONE JOINT SURG AM, V63, P152, DOI 10.2106/00004623-198163010-00020
   de Blacam C, 2014, J PLAST RECONSTR AES, V67, P607, DOI 10.1016/j.bjps.2014.01.044
   FITZGERALD RH, 1985, J BONE JOINT SURG AM, V67A, P175, DOI 10.2106/00004623-198567020-00001
   Follmar KE, 2007, PLAST RECONSTR SURG, V119, p138E, DOI 10.1097/01.prs.0000259203.79909.7e
   Goudie EB, 2012, INT WOUND J, V9, P132, DOI 10.1111/j.1742-481X.2011.00869.x
   Hayashida K, 2016, J TISSUE VIABILITY, V25, P220, DOI 10.1016/j.jtv.2016.06.007
   Hayashida K, 2012, OSTOMY WOUND MANAG, V58, P32
   Ichioka S, 2005, J Wound Care, V14, P105
   Jolly Gary Peter, 2004, Ostomy Wound Manage, V50, P44
   Kairinos N, 2014, PLAST RECONSTR SURG, V133, P1178, DOI 10.1097/PRS.0000000000000130
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nakamichi M, 2016, AM J PATHOL, V186, P3203, DOI 10.1016/j.ajpath.2016.08.015
   Noguchi S, 2004, HUM REPROD, V19, P1629, DOI 10.1093/humrep/deh254
   Price P, 2004, CLIN INFECT DIS, V39, pS129, DOI 10.1086/383274
   SMITH DG, 1992, J BONE JOINT SURG AM, V74A, P571, DOI 10.2106/00004623-199274040-00013
   WELLISZ T, 1990, PLAST RECONSTR SURG, V85, P457, DOI 10.1097/00006534-199003000-00023
NR 25
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JUL-AUG
PY 2018
VL 57
IS 4
BP 816
EP 820
DI 10.1053/j.jfas.2017.11.011
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA GL3KJ
UT WOS:000437032500035
PM 29605553
DA 2026-07-24
ER

PT J
AU Kotani, S
   Inoue, Y
   Wakatabe, M
   Yashiro, H
   Hase, M
AF Kotani, Sohsyu
   Inoue, Yoshito
   Wakatabe, Makoto
   Yashiro, Hideki
   Hase, Manabu
TI Successful Endovascular Repair of an Aortobronchial Fistula due to
   Takayasu Arteritis
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
AB Endovascular approaches to treating a diseased ascending aorta are challenging. We report the use of an endovascular occlusion device for successful closure of a ruptured penetrating atherosclerotic ulcer of an ascending aorta. A 47-year-old female patient with Takayasu arteritis complained of a worsening hemoptysis. She had a history of Bentall procedure for a sinus of Valsalva aneurysm and redo surgery for a ruptured penetrating atherosclerotic ulcer close to the distal anastomosis. She developed methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis after the second procedure and required negative pressure wound therapy. Computed tomographic angiography revealed recurrence of a ruptured penetrating aortic ulcer and an aortobronchial fistula. Because of the high risk of redo sternotomy after MRSA mediastinitis, we used an endovascular occlusion device to achieve successful percutaneous closure. The patient was discharged without any complications. Postoperative computed tomography scans showed that the endovascular device was positioned without migration and that complete thrombosis of the penetrating atherosclerotic ulcer was achieved. This is the first report on endovascular repair of a ruptured penetrating atherosclerotic ulcer of the ascending aorta in Takayasu arteritis.
C1 [Kotani, Sohsyu; Inoue, Yoshito; Wakatabe, Makoto] Hiratsuka City Hosp, Dept Cardiovasc Surg, Minamihara 1-19-1, Hiratsuka, Kanagawa, Japan.
   [Yashiro, Hideki; Hase, Manabu] Hiratsuka City Hosp, Dept Radiol, Hiratsuka, Kanagawa, Japan.
RP Kotani, S (通讯作者)，Hiratsuka City Hosp, Dept Cardiovasc Surg, Minamihara 1-19-1, Hiratsuka, Kanagawa, Japan.
EM sohsyu_k@yahoo.co.jp
RI Inoue, Yoshito/KIK-5596-2024
OI Inoue, Yoshito/0000-0001-8297-4797
CR Baikoussis NG, 2017, J VASC SURG, V66, P1587, DOI 10.1016/j.jvs.2017.07.064
   Ghoreishi M, 2020, ANN THORAC SURG, V109, P678, DOI 10.1016/j.athoracsur.2019.07.015
   Huh U, 2017, ANN THORAC SURG, V104, pE413, DOI 10.1016/j.athoracsur.2017.08.003
   Jung JH, 2018, EUR J VASC ENDOVASC, V55, P888, DOI 10.1016/j.ejvs.2018.02.030
   Kanaoka Y, 2017, ANN VASC SURG, V39, DOI 10.1016/j.avsg.2016.06.032
   Noble S, 2012, CATHETER CARDIO INTE, V79, P334, DOI 10.1002/ccd.23094
NR 6
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD FEB
PY 2021
VL 71
AR 533.e13
DI 10.1016/j.avsg.2020.08.152
EA FEB 2021
PG 4
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA RC0NM
UT WOS:000632500700059
PM 32949744
DA 2026-07-24
ER

PT J
AU Hospenthal, DR
   Murray, CK
   Andersen, RC
   Bell, RB
   Calhoun, JH
   Cancio, LC
   Cho, JM
   Chung, KK
   Clasper, JC
   Colyer, MH
   Conger, NG
   Costanzo, GP
   Crouch, HK
   Curry, TK
   D'Avignon, LC
   Dorlac, WC
   Dunne, JR
   Eastridge, BJ
   Ficke, JR
   Fleming, ME
   Forgione, MA
   Green, AD
   Hale, RG
   Hayes, DK
   Holcomb, JB
   Hsu, JR
   Kester, KE
   Martin, GJ
   Moores, LE
   Obremskey, WT
   Petersen, K
   Renz, EM
   Saffle, JR
   Solomkin, JS
   Sutter, DE
   Tribble, DR
   Wenke, JC
   Whitman, TJ
   Wiesen, AR
   Wortmann, GW
AF Hospenthal, Duane R.
   Murray, Clinton K.
   Andersen, Romney C.
   Bell, R. Bryan
   Calhoun, Jason H.
   Cancio, Leopoldo C.
   Cho, John M.
   Chung, Kevin K.
   Clasper, Jon C.
   Colyer, Marcus H.
   Conger, Nicholas G.
   Costanzo, George P.
   Crouch, Helen K.
   Curry, Thomas K.
   D'Avignon, Laurie C.
   Dorlac, Warren C.
   Dunne, James R.
   Eastridge, Brian J.
   Ficke, James R.
   Fleming, Mark E.
   Forgione, Michael A.
   Green, Andrew D.
   Hale, Robert G.
   Hayes, David K.
   Holcomb, John B.
   Hsu, Joseph R.
   Kester, Kent E.
   Martin, Gregory J.
   Moores, Leon E.
   Obremskey, William T.
   Petersen, Kyle
   Renz, Evan M.
   Saffle, Jeffrey R.
   Solomkin, Joseph S.
   Sutter, Deena E.
   Tribble, David R.
   Wenke, Joseph C.
   Whitman, Timothy J.
   Wiesen, Andrew R.
   Wortmann, Glenn W.
TI Executive Summary: Guidelines for the Prevention of Infections
   Associated With Combat-Related Injuries: 2011 Update Endorsed by the
   Infectious Diseases Society of America and the Surgical Infection
   Society
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE Guidelines; Infection; Combat; Trauma; Prevention
AB Despite advances in resuscitation and surgical management of combat wounds, infection remains a concerning and potentially preventable complication of combat-related injuries. Interventions currently used to prevent these infections have not been either clearly defined or subjected to rigorous clinical trials. Current infection prevention measures and wound management practices are derived from retrospective review of wartime experiences, from civilian trauma data, and from in vitro and animal data. This update to the guidelines published in 2008 incorporates evidence that has become available since 2007. These guidelines focus on care provided within hours to days of injury, chiefly within the combat zone, to those combat-injured patients with open wounds or burns. New in this update are a consolidation of antimicrobial agent recommendations to a backbone of high-dose cefazolin with or without metronidazole for most postinjury indications and recommendations for redosing of antimicrobial agents, for use of negative pressure wound therapy, and for oxygen supplementation in flight.
C1 [Hospenthal, Duane R.] San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA.
   [Cancio, Leopoldo C.; Chung, Kevin K.; Costanzo, George P.; Eastridge, Brian J.; Hale, Robert G.; Hsu, Joseph R.; Renz, Evan M.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Andersen, Romney C.; Colyer, Marcus H.; Dunne, James R.; Fleming, Mark E.; Martin, Gregory J.; Whitman, Timothy J.; Wortmann, Glenn W.] Walter Reed Natl Mil Med Ctr Bethesda, Bethesda, MD USA.
   [Tribble, David R.] Infect Dis Clin Res Program, Bethesda, MD USA.
   [Bell, R. Bryan] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [Calhoun, Jason H.] Ohio State Univ, Columbus, OH 43210 USA.
   [Cho, John M.] Landstuhl Reg Med Ctr, Landstuhl, Germany.
   [Clasper, Jon C.; Green, Andrew D.] Royal Ctr Def Med, Inst Res & Dev, Birmingham, W Midlands, England.
   [Conger, Nicholas G.; Forgione, Michael A.] Keesler Med Ctr, Keesler AFB, MS USA.
   [Curry, Thomas K.] Madigan Army Med Ctr, Ft Lewis, WA USA.
   [Wiesen, Andrew R.] Western Reg Med Command, Ft Lewis, WA USA.
   [D'Avignon, Laurie C.] USAF, Med Support Agcy, Lackland AFB, TX USA.
   [Dorlac, Warren C.; Solomkin, Joseph S.] Univ Cincinnati, Cincinnati, OH USA.
   [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA.
   [Kester, Kent E.] Walter Reed Army Inst Res, Silver Spring, MD USA.
   [Moores, Leon E.] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA.
   [Obremskey, William T.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Petersen, Kyle] USN, Med Res Ctr, Silver Spring, MD USA.
   [Saffle, Jeffrey R.] Univ Utah, Salt Lake City, UT USA.
C3 Brooke Army Medical Center; Walter Reed National Military Medical
   Center; Oregon Health & Science University; University System of Ohio;
   Ohio State University; Landstuhl Regional Medical Center; University of
   Birmingham; Royal Centre for Defence Medicine; Madigan Army Medical
   Center; United States Department of Defense; United States Air Force;
   University System of Ohio; University of Cincinnati; University of Texas
   System; University of Texas Health Science Center Houston; Walter Reed
   Army Institute of Research (WRAIR); United States Department of Defense;
   United States Army; Vanderbilt University; United States Department of
   Defense; United States Navy; Utah System of Higher Education; University
   of Utah
RP Hospenthal, DR (通讯作者)，San Antonio Mil Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM duane.hospenthal@us.army.mil
RI Martin, Gregory/CAG-8518-2022; /AGJ-2398-2022; Fleming,
   Mark/HJA-3208-2022; Obremskey, William/HRA-4704-2023; Kester,
   Kent/AAF-8235-2020
OI holcomb, john/0000-0001-8312-9157; Fleming, Mark/0000-0002-4753-2632;
   Obremskey, William/0000-0002-8942-1842; Kester,
   Kent/0000-0002-5056-0802; Solomkin, Joseph/0000-0001-6382-4902;
   Andersen, Romney/0009-0000-3507-7612; Bell, R.
   Bryan/0000-0002-3775-109X; Petersen, Kyle/0000-0003-2429-5002;
   Hospenthal, Duane/0000-0003-3354-8075; Hsu, Joseph/0000-0001-9341-2554
FU US Army Medical Command
FX Financial support for the consensus conference and publication of the
   Journal of Trauma supplement was provided by the US Army Medical
   Command.
CR D'Avignon LC, 2011, J TRAUMA, V71, pS282, DOI 10.1097/TA.0b013e318227adc2
   Forgione MA, 2011, J TRAUMA, V71, pS258, DOI 10.1097/TA.0b013e318227ad86
   Hospenthal DR, 2011, J TRAUMA, V71, pS290, DOI 10.1097/TA.0b013e318227add8
   Martin GJ, 2011, J TRAUMA, V71, pS270, DOI 10.1097/TA.0b013e318227adae
   Murray CK, 2011, J TRAUMA, V71, pS235, DOI 10.1097/TA.0b013e318227ac5f
   Petersen K, 2011, J TRAUMA, V71, pS264, DOI 10.1097/TA.0b013e318227ad9a
NR 6
TC 16
Z9 17
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD AUG
PY 2011
VL 71
SU 2
BP S202
EP S209
DI 10.1097/TA.0b013e318227ac37
PG 8
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 806XB
UT WOS:000293849300002
PM 21814088
DA 2026-07-24
ER

PT J
AU Harris, BN
   Bewley, AF
AF Harris, Brianna N.
   Bewley, Arnaud F.
TI Minimizing free flap donor-site morbidity
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE anterolateral thigh; donor-site morbidity; fibula flap; free flap;
   radial forearm
ID ANTEROLATERAL THIGH FLAP; FOREARM FREE-FLAP; THICKNESS-SKIN-GRAFT;
   HARVEST; RECONSTRUCTION; COMPLICATIONS; MANAGEMENT; FULL; ARM
AB Purpose of reviewFasciocutaneous and osteocutaneous free flap reconstruction has significantly changed the way surgeons reconstruct defects following ablation of head and neck tumors. Over time, success rates of free flaps have approached 98%, allowing surgeons to shift their focus to minimizing morbidities associated with the donor sites. The radial forearm, anterolateral thigh, and fibula free flaps are the three most commonly used flaps in head and neck reconstruction, and therefore each of their advantages and associated morbidities are of particular interest. The present article aims to review the morbidities associated with each of the commonly used head and neck free flaps and techniques to minimize them that are described in the most recent literature.Recent findingsNew techniques such as negative-pressure wound therapy, full thickness grafts, and rotational flaps have been developed recently that minimize these morbidities.SummaryThe techniques described in the current review may improve long-term patient outcomes both esthetically and functionally.
C1 [Harris, Brianna N.; Bewley, Arnaud F.] Univ Calif Davis, Davis Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Bewley, AF (通讯作者)，Univ Calif Davis, Davis Dept Otolaryngol Head & Neck Surg, 2521 Stockton Blvd,Suite 7200, Sacramento, CA 95817 USA.
EM abewley@ucdavis.edu
OI Harris, Brianna/0000-0001-6229-9907
CR Agostini T, 2013, J CRANIO MAXILL SURG, V41, P15, DOI 10.1016/j.jcms.2012.05.003
   Bach CA, 2015, HEAD NECK-J SCI SPEC, V38, P696
   Baj A, 2015, J ORAL MAXIL SURG, V73, P184, DOI 10.1016/j.joms.2014.07.043
   Brown MT, 1999, ARCH OTOLARYNGOL, V125, P1371, DOI 10.1001/archotol.125.12.1371
   Collins J, 2012, CAN J PLAST SURG, V20, P17, DOI 10.1177/229255031202000103
   ELLIOT D, 1988, BRIT J PLAST SURG, V41, P358, DOI 10.1016/0007-1226(88)90073-2
   Emerick KS, 2007, HEAD NECK-J SCI SPEC, V29, P573, DOI 10.1002/hed.20584
   Fang QG, 2014, J INT MED RES, V42, P231, DOI 10.1177/0300060513508041
   Feuvrier D, 2016, J PLAST RECONSTR AES, V69, P262, DOI 10.1016/j.bjps.2015.10.007
   Hanasono MM, 2010, PLAST RECONSTR SURG, V125, P209, DOI 10.1097/PRS.0b013e3181c495ed
   Hekner DD, 2013, PLAST RECONSTR SURG, V132, P387, DOI 10.1097/PRS.0b013e318295896c
   Ho MWS, 2013, JAMA OTOLARYNGOL, V139, P1048, DOI 10.1001/jamaoto.2013.4544
   Jaquet Y, 2012, ARCH OTOLARYNGOL, V138, P38, DOI 10.1001/archoto.2011.216
   Kimata Y, 2000, PLAST RECONSTR SURG, V106, P584, DOI 10.1097/00006534-200009030-00009
   Klein S, 2005, MICROSURG, V25, P538, DOI 10.1002/micr.20169
   Klinkenberg M, 2013, PLAST RECONSTR SURG, V131, P293, DOI 10.1097/PRS.0b013e31827786bc
   Knott PD, 2015, HEAD NECK
   Li P, 2015, J ORAL MAXIL SURG, V73, P1637, DOI 10.1016/j.joms.2015.01.036
   Momoh AO, 2011, PLAST RECONSTR SURG, V128, P714, DOI 10.1097/PRS.0b013e318221dc2a
   Novak CB, 2007, MICROSURG, V27, P651, DOI 10.1002/micr.20425
   Orlik JR, 2014, J OTOLARYNGOL-HEAD N, V43, DOI 10.1186/1916-0216-43-1
   Riecke B, 2015, INT J ORAL MAX SURG, V44, P937, DOI 10.1016/j.ijom.2015.02.021
   Shindo M, 2000, ARCH OTOLARYNGOL, V126, P1467, DOI 10.1001/archotol.126.12.1467
   Sidebottom AJ, 2000, INT J ORAL MAX SURG, V29, P194, DOI 10.1016/S0901-5027(00)80091-0
   Sinclair CF, 2012, MICROSURG, V32, P255, DOI 10.1002/micr.21950
   Spiegel JH, 2007, LARYNGOSCOPE, V117, P485, DOI 10.1097/MLG.0b013e31802d6e66
   Tan ST, 2012, HEAD NECK-J SCI SPEC, V34, P1434, DOI 10.1002/hed.21943
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   Vaezi A, 2014, HEAD NECK TUMOR BIOL
   Wong CH, 2010, HEAD NECK-J SCI SPEC, V32, P529, DOI 10.1002/hed.21204
   Wood JW, 2013, JAMA OTOLARYNGOL, V139, P183, DOI 10.1001/jamaoto.2013.1357
   Yun TK, 2015, ARCH PLAST SURG-APS, V42, P769, DOI 10.5999/aps.2015.42.6.769
NR 32
TC 44
Z9 47
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD OCT
PY 2016
VL 24
IS 5
BP 447
EP 452
DI 10.1097/MOO.0000000000000286
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA DW8PH
UT WOS:000383917500013
PM 27455033
DA 2026-07-24
ER

PT J
AU Webb, MA
   Bleszynski, MS
   Chen, L
   Chiu, J
   Meneghetti, A
   Panton, ON
AF Webb, Mitchell A.
   Bleszynski, Michael S.
   Chen, Leo
   Chiu, Jack
   Meneghetti, Adam
   Panton, Ormond N.
TI Incisional wound VAC and risk-adjusted SSI rates in colorectal surgery:
   A tertiary centre experience
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID SURGICAL-SITE INFECTIONS; NEGATIVE-PRESSURE THERAPY; AMERICAN-COLLEGE;
   LAPAROTOMY; PREVENTION; METAANALYSIS; CALCULATOR; TRIAL
AB Background: In colorectal surgery, indications for incisional negative pressure wound therapy (iVAC) remain unclear. We sought to compare rates of surgical site infection (SSI) in patients who received iVAC or standard sterile dressing (SSD).
   Methods: Institutional colorectal NSQIP data between 2014 and 2018 was reviewed. SSI rates were compared between iVAC and SSD cohorts using the NSQIP surgical risk calculator (NSQIP SRC) for risk-adjusted analysis. Secondary outcomes included other wound complications, morbidity, mortality, disposition destination and overall length of stay.
   Results: 145 patients received iVAC while 544 received SSD. SSI was greater in iVAC than SSD (17% vs 9%, p = 0.009). iVAC was independently associated with SSI (OR 2.3, 95% CI 1.3-3.9). The presence of a colostomy strengthened this relationship. There was no difference in secondary outcomes.
   Conclusion: iVAC was independently associated with SSI with risk-adjusted analysis. This relationship was stronger in patients with a colostomy. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Webb, Mitchell A.; Bleszynski, Michael S.; Chen, Leo; Chiu, Jack; Meneghetti, Adam; Panton, Ormond N.] Univ British Columbia, Dept Surg, Div Gen Surg, 2775 Laurel St,11th Floor, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Webb, MA (通讯作者)，Univ British Columbia, Dept Surg, Div Gen Surg, 2775 Laurel St,11th Floor, Vancouver, BC V5Z 1M9, Canada.
EM Mitchell.webb@alumni.ubc.ca
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NR 33
TC 8
Z9 8
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2019
VL 217
IS 5
SI SI
BP 948
EP 953
DI 10.1016/j.amjsurg.2018.12.019
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HT4CY
UT WOS:000464512000026
PM 30612695
DA 2026-07-24
ER

PT J
AU Carey, JN
   Sheckter, CC
   Watt, AJ
   Lee, GK
AF Carey, Joseph N.
   Sheckter, Clifford C.
   Watt, Andrew J.
   Lee, Gordon K.
TI Intra-abdominal pedicled rectus abdominis muscle flap for treatment of
   high-output enterocutaneous fistulae: Case reports and review of
   literature
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Enterocutaneous fistula; Pedicled flap; Rectus abdominis
ID SURGICAL REPAIR; CLOSURE; ABDOMEN
AB Despite advances in nutritional supplementation, sepsis management, percutaneous drainage and surgical technique, enterocutaneous fistulae remain a considerable source of morbidity and mortality. Use of adjunctive modalities including negative pressure wound therapy and fibrin glue have been shown to improve the rapidity of fistula closure; however, the overall rate of closure remains poor. The challenge of managing chronic, high-output proximal enterocutaneous fistulae can be successfully achieved with appropriate medical management and intra-abdominal placement of pedicled rectus abdominis muscle flaps. We report two cases of recalcitrant high output enterocutaneous fistulae that were treated successfully with pedicled intra-abdominal rectus muscle flaps. Indications for pedicled intra-abdominal rectus muscle flaps include persistent patency despite a reasonable trial of non-operative intervention, failure of traditional operative interventions (serosal patch, Graham patch), and persistent electrolyte and nutritional abnormalities in the setting of a high-output fistula. (C) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Carey, Joseph N.; Sheckter, Clifford C.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
   [Watt, Andrew J.; Lee, Gordon K.] Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
C3 University of Southern California; Stanford University
RP Lee, GK (通讯作者)，Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
EM glee@stanford.edu
CR Chander J, 2004, WORLD J SURG, V28, P179, DOI 10.1007/s00268-003-7017-5
   Chang SH, 2010, J PLAST RECONSTR AES, V63, P1055, DOI 10.1016/j.bjps.2009.10.024
   Draus JM, 2006, SURGERY, V140, P570, DOI 10.1016/j.surg.2006.07.003
   Dudrick SJ, 1999, WORLD J SURG, V23, P570, DOI 10.1007/PL00012349
   Hollington P, 2004, BRIT J SURG, V91, P1646, DOI 10.1002/bjs.4788
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   Scala M, 2012, PLAST RECONSTR SURG, V129, p391E, DOI 10.1097/PRS.0b013e31823af180
NR 10
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2013
VL 66
IS 8
BP 1145
EP 1148
DI 10.1016/j.bjps.2012.12.008
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 178IM
UT WOS:000321441300026
PM 23317765
DA 2026-07-24
ER

PT J
AU Xue, YM
   Wang, N
   Wu, CY
   Yang, HM
   Zou, XF
   He, HW
   Shi, Y
AF Xue, Yimin
   Wang, Na
   Wu, Chaoyu
   Yang, Hongmei
   Zou, Xiongfei
   He, Huaiwu
   Shi, Yan
TI Case Report: From septic shock to recovery - a battle against lethal
   necrotizing soft tissue infection
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE necrotizing soft tissue infections; streptococcus pyogenes; septic
   shock; V-A ECMO; surgical debridement; multidisciplinary care
AB Necrotizing soft tissue infections (NSTIs) are life-threatening surgical emergencies associated with high morbidity and mortality. We report the case of a 40-year-old woman who presented with progressive left lower limb pain and swelling. CT revealed inflammatory changes involving the deep soft tissues. Despite initial surgical debridement, irrigation, and negative pressure wound therapy (NPWT), the patient rapidly deteriorated and progressed to septic shock, requiring intensive care unit (ICU) admission, broad-spectrum antibiotics, advanced life-sustaining support with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), and continuous renal replacement therapy (CRRT). Cultures from the wound drainage identified Streptococcus pyogenes (S. pyogenes), leading to targeted antimicrobial therapy. Ongoing clinical deterioration and elevated myoglobin levels prompted repeated surgical debridements for progressive muscle and skin necrosis. Following multiple staged debridements and multidisciplinary management, the patient achieved hemodynamic stability, successful wound closure, and skin grafting. This case highlights the critical need for timely diagnosis, aggressive surgical and medical management, and coordinated multidisciplinary care in improving outcomes for patients with severe NSTIs.
C1 [Xue, Yimin; Wang, Na; Wu, Chaoyu; Yang, Hongmei; He, Huaiwu; Shi, Yan] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Intens Care Unit, Beijing, Peoples R China.
   [Xue, Yimin] Fujian Med Univ, Affiliated Prov Hosp, Dept Cardiovasc Crit Care Med, Fujian Prov Hosp,Shengli Clin Med Coll, Fuzhou, Fujian, Peoples R China.
   [Wu, Chaoyu] Guizhou Prov Peoples Hosp, Dept Emergency Med, Guiyang, Guizhou, Peoples R China.
   [Yang, Hongmei] Lijiang Peoples Hosp, Dept Intens Care Unit, Lijiang, Yunnan, Peoples R China.
   [Zou, Xiongfei] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthoped Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Fujian Medical University; Fujian Provincial Hospital; Chinese Academy
   of Medical Sciences - Peking Union Medical College; Peking Union Medical
   College Hospital; Peking Union Medical College
RP Shi, Y (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Intens Care Unit, Beijing, Peoples R China.
EM pumchshi@sina.com
FU Fujian Provincial Health Technology Project10.13039/501100017686
   [ZC201904394]; Clinical Fund of Peking Union Medical College Hospital
   [320.6750.18428]; Wu Jieping Medical Foundation [2023Y9287]; Joint Funds
   for the Innovation of Science and Technology, Fujian Province
   [2023GGA009]; Fujian Provincial Health Technology Project
FX The author(s) declare financial support was received for the research
   and/or publication of this article. This work was supported by the
   Clinical Fund of Peking Union Medical College Hospital (ZC201904394),
   the Wu Jieping Medical Foundation (320.6750.18428), the Joint Funds for
   the Innovation of Science and Technology, Fujian Province (2023Y9287),
   and the Fujian Provincial Health Technology Project (2023GGA009).
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NR 26
TC 0
Z9 0
U1 2
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD SEP 26
PY 2025
VL 16
AR 1680818
DI 10.3389/fimmu.2025.1680818
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 8JX8U
UT WOS:001590448700001
PM 41080549
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mao, TC
   Zhou, X
   Tian, MN
   Zhang, YM
   Wang, SL
AF Mao, Tong-chun
   Zhou, Xuan
   Tian, Meng-nan
   Zhang, Yi-ming
   Wang, Shao-liang
TI A rare case of male Fournier's gangrene with mixed Actinomyces
   turicensis infection
SO BMC UROLOGY
LA English
DT Article
DE Fournier's gangrene; Actinomyces; Necrotizing fasciitis; Skin grafting;
   Case report
AB Background Fournier's gangrene (FG), a urological emergency with high mortality, is an infectious necrotizing fasciitis of the perineal and genital regions. The majority of FG is caused by polymicrobial organisms involving mixed aerobes and anaerobes but rarely reveals Actinomyces species. Case presentation We report a healthy 67-year-old Asian male who presented with rapidly progressive painful swelling of the scrotum. Clinically diagnosed with FG, the patient underwent an emergency radical debridement, followed by broad-spectrum antibiotics and negative pressure wound therapy. The identification of the causative microorganisms showed Actinomyces turicensis and the antibiotic treatment was adjusted accordingly. After wound bed preparation, we took split-thickness skin grafts to cover the scrotal wound. Active management to minimize faecal contamination was applied throughout the whole course of treatment and repair. The patient was satisfied with the outcome. This was an extremely rare case of A. turicensis as the main causative pathogen of FG. Conclusions FG due to Actinomyces species is rarely reported, but we should still consider this pathogenic microorganism that has long been neglected.
C1 [Mao, Tong-chun; Zhou, Xuan; Tian, Meng-nan; Zhang, Yi-ming; Wang, Shao-liang] Army Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China.
C3 Army Medical University
RP Wang, SL (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Chongqing, Peoples R China.
EM xqzxwsl@163.com
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NR 16
TC 9
Z9 11
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2490
J9 BMC UROL
JI BMC Urol.
PD FEB 23
PY 2022
VL 22
IS 1
AR 25
DI 10.1186/s12894-022-00975-z
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ZG4NW
UT WOS:000760237300001
PM 35197026
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pérez-Acevedo, G
   Bosch-Alcaraz, A
   Torra-Bou, JE
AF Perez-Acevedo, Gemma
   Bosch-Alcaraz, Alejandro
   Torra-Bou, Joan Enric
TI Larval Therapy for Treatment of Chronic Wounds Colonized by
   Multi-resistant Pathogens in a Pediatric Patient A Case Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Chronic wounds; Complex care; Maggot debridement therapy; Pediatrics
ID MAGGOT THERAPY; PSEUDOMONAS-AERUGINOSA; EFFICACY
AB BACKGROUND: Chronic wounds are susceptible to colonization with gram-positive and gram-negative bacteria that may be resistant to antimicrobial dressings and systemic antibiotics. In January 2004, the US Food and Drugs Administration approved use of medicinal larvae for use in humans and animals for resistant organisms. Despite use in adults, there is a paucity of evidence evaluating its efficacy and safety in the pediatric population. CASE: T was a 5-year-old boy with several chronic wounds infected with multidrug-resistant Pseudomonas aeruginosa. The wounds were originally treated with chemical debridement, dressings containing ionic silver, negative-pressure wound therapy (NPWT), and antibiotics without success. Consequently, a multidisciplinary team implemented maggot debridement therapy (MDT). CONCLUSIONS: After MDT, one wound completely epithelialized and the other wounds achieved a reduction in size with 70% epithelization. Therapy also led to a reduction in wound odor, exudate, and pain. The other wounds were closed after additional management with dressing containing nanocrystalline silver and NPWT.
C1 [Perez-Acevedo, Gemma; Bosch-Alcaraz, Alejandro; Torra-Bou, Joan Enric] St Joan Deu Hosp, Barcelona, Spain.
RP Bosch-Alcaraz, A (通讯作者)，Hosp St Joan Deu, Pediat Intens Care Unit, P St Joan Deu 2, Barcelona 08950, Spain.
EM gperez@sjdhospitalbarcelona.org; abosch@sjdhospitalbarcelona.org;
   jetorrabou@hotmail.com
RI Bosch Alcaraz, Alejandro/KDO-0418-2024
OI Bosch Alcaraz, Alejandro/0000-0001-6369-9697; Torra-Bou, Joan
   Enric/0000-0001-9410-4668
CR [Anonymous], WHO publishes list of bacteria for which new antibiotics are urgently needed
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NR 23
TC 3
Z9 5
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD JUL-AUG
PY 2022
VL 49
IS 4
BP 373
EP 378
DI 10.1097/WON.0000000000000893
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 2T4DU
UT WOS:000822428200011
PM 35809014
DA 2026-07-24
ER

PT J
AU Aldana, PC
   Khachemoune, A
AF Aldana, Paola C.
   Khachemoune, Amor
TI Diabetic Foot Ulcers: Appraising Standard of Care and Reviewing New
   Trends in Management
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; DOUBLE-BLIND; LIMB; AMPUTATION; TISSUE;
   BECAPLERMIN; PREVENTION; PATHWAYS; OUTCOMES
AB Diabetic foot ulcers (DFU) are one of the most common diabetes complications and are associated with significant morbidity and mortality. Current DFU standard of care (SOC) involves four principles: (1) pressure relief, (2) debridement, (3) infection management, and (4) revascularization when indicated. Despite the current SOC, many DFU persist, warranting a new approach for the management of these complex wounds. This review aims to summarize the current SOC as well as the latest trends in adjunctive therapies that may become the new SOC in DFU management. These include negative pressure wound therapy and hyperbaric oxygen therapy, bioengineered skin substitutes, growth factors, shockwave therapy, and several others. These novel therapies have shown significant DFU clinical improvement among subsets of DFU patients. However, much of the literature comes from smaller trials with inconsistent patient selection and outcomes measured, making it difficult to assess the true clinical benefit of these treatments. While novel therapies are promising for the interdisciplinary approach to DFU management, many still lack sufficient evidence, and their efficacy remains to be determined.
C1 [Aldana, Paola C.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Khachemoune, Amor] Vet Affairs Med Ctr, Brooklyn, NY 11209 USA.
   [Khachemoune, Amor] SUNY Downstate, Dept Dermatol, 800 Poly Pl, Brooklyn, NY 11209 USA.
C3 University System of Maryland; University of Maryland Baltimore; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Khachemoune, A (通讯作者)，Vet Affairs Med Ctr, Brooklyn, NY 11209 USA.; Khachemoune, A (通讯作者)，SUNY Downstate, Dept Dermatol, 800 Poly Pl, Brooklyn, NY 11209 USA.
EM amorkh@gmail.com
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NR 55
TC 73
Z9 89
U1 3
U2 39
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PD APR
PY 2020
VL 21
IS 2
BP 255
EP 264
DI 10.1007/s40257-019-00495-x
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KZ3JH
UT WOS:000523160800007
PM 31848923
DA 2026-07-24
ER

PT J
AU Orsini, JA
AF Orsini, James A.
TI Update on Managing Serious Wound Infections in Horses: Wounds Involving
   Bone
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Review
DE Wounds; Bone; Infection; Equine; Horse
ID VACUUM-ASSISTED CLOSURE; IMPREGNATED COLLAGEN SPONGES; REGIONAL LIMB
   PERFUSION; IN-VITRO ELUTION; NEGATIVE-PRESSURE; MAGGOT DEBRIDEMENT;
   STAPHYLOCOCCUS-AUREUS; ORTHOPEDIC INFECTIONS; SEPTIC PERITONITIS;
   RHODOCOCCUS-EQUI
AB Most serious wound infections involve at least one, and usually a combination, of these factors: (1) extensive contamination or bacterial burden that overwhelms the patient's resources, (2) refugia which protect the bacteria from host defenses and antibiotic drugs, (3) immunocompromise, (4) poor perfusion, and (5) antibiotic resistance of the wound pathogen(s). In horses, wounds that involve bone, range in severity, complexity, and long-term impact from those containing a sequestrum, to septic osteomyelitis at the site of internal fixation. The principles of successful treatment are as follows: (1) debride the devitalized or irreparably damaged bone and soft tissue, (2) preserve and protect the vascular supply to bone and soft tissue, (3) maintain or restore structural integrity at the site, (4) control infection through appropriate local/regional and systemic antibiotic therapy and (5) protect the wound from further contamination, desiccation, maceration, and trauma. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Orsini, James A.] Univ Penn, Sch Vet Med, Kennett Sq, PA 19348 USA.
C3 University of Pennsylvania
RP Orsini, JA (通讯作者)，Univ Penn, New Bolton Ctr, Clin Studies, 382 West St Rd, Kennett Sq, PA 19348 USA.
EM orsini@vet.upenn.edu
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NR 119
TC 8
Z9 9
U1 1
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD AUG
PY 2017
VL 55
BP 123
EP 138
DI 10.1016/j.jevs.2017.01.004
PG 16
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FD4TD
UT WOS:000407523900019
DA 2026-07-24
ER

PT J
AU Benzar, I
   Levytskyi, A
   Khrapach, V
   Unukovych, D
AF Benzar, Iryna
   Levytskyi, Anatolii
   Khrapach, Vasyl
   Unukovych, Dmytro
TI Warzone pediatric trauma care: Lessons from civilian medical staff in
   Kyiv
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE children multidisciplinary hospital; negative pressure wound therapy;
   pediatric military trauma; war in Ukraine
ID WAR
AB Introduction: The article discusses the challenges faced by civilian healthcare providers in Kyiv, Ukraine, during the conflict in treating pediatric trauma resulting from war-related incidents. Methods: The authors share their experiences and insights from managing a series of 12 pediatric patients admitted to the Ohmatdyt children's hospital between February 25 and April 1, 2022. During this period, the hospital was under constant threat due to the military conflict. Results: The patients, ranging in age from 3 months to 17 years, suffered injuries from various causes, including vehicle shootings, explosions, and other traumatic events. The interventions and timely management are discussed, and two detailed clinical cases are presented to illustrate the complexities of treating pediatric trauma in a warzone. Conclusion: In summary, the article sheds light on the unique challenges faced by healthcare providers in a warzone when treating pediatric trauma. It underscores the importance of timely intervention, effective triage, and the utilization of advanced medical techniques to improve patient outcomes in such challenging circumstances.
C1 [Benzar, Iryna; Levytskyi, Anatolii] Bogomolets Natl Med Univ, Dept Pediat Surg, Kiev, Ukraine.
   [Khrapach, Vasyl; Unukovych, Dmytro] Bogomolets Natl Med Univ, Dept Pediat Surg, Kiev, Ukraine.
   [Unukovych, Dmytro] Karolinska Univ Hosp, Dept Plast & Craniofacial Surg, NB06, S-17164 Stockholm, Sweden.
C3 Bogomolets National Medical University; Bogomolets National Medical
   University; Karolinska Institutet; Karolinska University Hospital
RP Unukovych, D (通讯作者)，Karolinska Univ Hosp, Dept Plast & Craniofacial Surg, NB06, S-17164 Stockholm, Sweden.
EM unukovych@gmail.com
RI Benzar, Iryna/ABU-0165-2022; Unukovych, Dmytro/AAW-6450-2020
OI Unukovych, Dmytro/0000-0002-1357-9125
CR Bitterman Y, 2016, MIL MED, V181, P849, DOI 10.7205/MILMED-D-15-00427
   Guha-Sapir D, 2018, LANCET GLOB HEALTH, V6, pE103, DOI [10.1016/s2214-109x(17)30469-2, 10.1016/S2214-109X(17)30469-2]
   Jain RP, 2020, BMJ GLOB HEALTH, V5, DOI 10.1136/bmjgh-2019-001980
   Kornblith AE, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.2922
   Laville V, 2019, EUR J TRAUMA EMERG S, V45, P437, DOI 10.1007/s00068-018-0915-x
   Liu X, 2018, INT J SURG, V53, P72, DOI 10.1016/j.ijsu.2018.02.064
   McIntyre J, 2020, BMJ MILITARY HEALTH, V166, P261, DOI 10.1136/jramc-2019-001304
   Naaman O, 2020, J PEDIATR SURG, V55, P523, DOI 10.1016/j.jpedsurg.2019.02.022
   Pouzet L., 2021, NEGATIVE PRESSURE WO, P242
   Samuel N, 2021, J TRAUMA ACUTE CARE, V90, pE1, DOI 10.1097/TA.0000000000002974
   Slone M, 2016, CHILD PSYCHIAT HUM D, V47, P950, DOI 10.1007/s10578-016-0626-7
   Unukovych D, 2022, BJS-BRIT J SURG, V109, P785, DOI 10.1093/bjs/znac168
   Wren SM, 2020, JAMA SURG, V155, P114, DOI 10.1001/jamasurg.2019.4547
NR 13
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAR
PY 2024
VL 48
IS 3
BP 540
EP 546
DI 10.1002/wjs.12091
EA FEB 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KL7D3
UT WOS:001158246100001
PM 38319195
DA 2026-07-24
ER

PT J
AU Janowska, A
   Oranges, T
   Chiricozzi, A
   Romanelli, M
   Dini, V
AF Janowska, Agata
   Oranges, Teresa
   Chiricozzi, Andrea
   Romanelli, Marco
   Dini, Valentina
TI Synergism of Therapies After Postoperative Autograft Failure in a
   Patient With Melanoma of the Foot Misdiagnosed as a Pressure Ulcer
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE CELLUTOME; epidermal skin grafting; melanoma; foot; autograft
AB Introduction: Amelanotic melanoma of the foot is a diagnostic challenge for physicians as it often appears as a benign lesion. In order to make the correct diagnosis at early stages, it is recommended to perform a biopsy of worsening lesions that are refractory to standard treatments, particularly nonhealing wounds. Case report: The authors describe the case of a 57-year-old man with amelanotic melanoma of the foot that had been treated as a pressure ulcer for 3 months. He underwent wide local excision of the melanoma and an application of skin autograft. After skin autograft failure, optimal wound bed preparation was achieved through negative pressure wound therapy and compression bandages associated with hyperbaric therapy. Complete wound healing was obtained with an epidermal fractional skin grafting system combined with compressive inelastic bandages. Conclusions: Physicians must remain highly cautious of ulcerated lesions of the foot and may consider epidermal fractional skin grafting as a valid therapeutic option in case of postsurgical wounds resulting from wide local excision of malignant melanomas.
C1 [Janowska, Agata; Oranges, Teresa; Chiricozzi, Andrea; Romanelli, Marco; Dini, Valentina] Univ Pisa, Dept Dermatol, Wound Healing Res Unit, Pisa, Italy.
C3 University of Pisa
RP Janowska, A (通讯作者)，Univ Pisa, Dept Dermatol, Via Roma 67, I-56124 Pisa, Italy.
EM dottoressajanowska@gmail.com
RI Chiricozzi, Andrea/AAC-3343-2019; Janowska, Agata/HHS-7036-2022;
   Oranges, Teresa/AAM-9690-2020; dini, valentina/F-7747-2017
OI Janowska, Agata/0000-0002-2271-3859; Oranges,
   Teresa/0000-0002-7277-3278; dini, valentina/0000-0002-8537-1999
CR Bristow I, 2016, CLIN PODIATR MED SUR, V33, P409, DOI 10.1016/j.cpm.2016.02.008
   Cai SS, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.853
   Gualandri L, 2009, J EUR ACAD DERMATOL, V23, P283, DOI 10.1111/j.1468-3083.2008.03041.x
   Howarth Ashley L, 2015, Burns, V41, pe57, DOI [10.1016/j.burns.2015.02.021, 10.1016/j.burns.2015.02.021]
   Janowska A, 2016, INT WOUND J, V13, P47, DOI 10.1111/iwj.12632
   Osborne SN, 2016, ADV SKIN WOUND CARE, V29, P57, DOI 10.1097/01.ASW.0000476072.88818.aa
   Romanelli M, 2015, BRIT J DERMATOL, V172, P853, DOI 10.1111/bjd.13580
   Shaikh WR, 2012, ARCH DERMATOL, V148, P30, DOI 10.1001/archdermatol.2011.264
   Smith OJ, 2017, INT WOUND J, V14, P555, DOI 10.1111/iwj.12644
   Yin NC, 2013, INT J LOW EXTR WOUND, V12, P289, DOI 10.1177/1534734613512505
NR 10
TC 5
Z9 5
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2018
VL 30
IS 4
BP E41
EP E43
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7HI
UT WOS:000441907100002
PM 29718821
DA 2026-07-24
ER

PT J
AU Weidenhagen, R
   Hartl, WH
   Gruetzner, KU
   Eichhorn, ME
   Spelsberg, F
   Jauch, KW
AF Weidenhagen, Rolf
   Hartl, Wolfgang H.
   Gruetzner, Klaus U.
   Eichhorn, Martin E.
   Spelsberg, Fritz
   Jauch, Karl W.
TI Anastomotic Leakage After Esophageal Resection: New Treatment Options by
   Endoluminal Vacuum Therapy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID ASSISTED CLOSURE THERAPY; ENDOSCOPIC TREATMENT; CARDIAC-SURGERY; PLASTIC
   STENTS; MANAGEMENT; ESOPHAGOGASTRECTOMY; IMPLANTATION; PERFORATIONS;
   INFECTIONS; CARCINOMA
AB Background. Anastomotic leakage after esophagectomy is an important determinant of early and late morbidity and mortality. Control of the septic focus is essential when treating patients with anastomotic leakages. Surgical and endoscopic treatment options are limited.
   Methods. Between 2005 and 2009, we treated 6 patients who experienced an intrathoracic anastomotic leakage after esophageal resection. After all established therapeutic measures had failed, we explored the feasibility of an endoscopically assisted mediastinal vacuum therapy.
   Results. We were able to heal intrathoracic esophageal leakages in all 6 patients without any local complications and without the need for reoperation. One patient died because of a progressive pneumonia.
   Conclusions. Endoscopic vacuum-assisted closure of anastomotic leakages may help to overcome the limitations that are associated with intermittent endoscopic treatment and conventional drainage therapy. Our preliminary results suggest that this new concept may be suitable for those patients. (Ann Thorac Surg 2010;90:1674-81) (C) 2010 by The Society of Thoracic Surgeons
C1 Univ Munich, Univ Hosp Campus Grosshadern, Dept Surg, D-81377 Munich, Germany.
   Asklepios Ctr Thorac Surg, Gauting, Germany.
C3 University of Munich
RP Weidenhagen, R (通讯作者)，Univ Munich, Dept Surg, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
RI Eichhorn, Martin/GRE-9126-2022; hartl, Wolfgang/I-1981-2012
OI Eichhorn, Martin/0000-0002-0362-0374; 
CR Alanezi Khaled, 2004, Ann Thorac Cardiovasc Surg, V10, P71
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   Wehrmann T, 2005, GASTROINTEST ENDOSC, V62, P344, DOI 10.1016/j.gie.2005.03.001
   Weidenhagen R, 2007, VISZERALCHIRURGIE, V42, P165, DOI 10.1055/s-2007-960720
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
   Weidenhagen R, 2010, ANN THORAC SURG, V90, P1674, DOI 10.1016/j.athoracsur.2010.07.007
   White RA, 2005, J ORTHOP TRAUMA, V19, P56, DOI 10.1097/00005131-200501000-00011
NR 31
TC 104
Z9 117
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD NOV
PY 2010
VL 90
IS 5
BP 1674
EP 1681
DI 10.1016/j.athoracsur.2010.07.007
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 669LO
UT WOS:000283352200059
PM 20971288
DA 2026-07-24
ER

PT J
AU Moerenhout, K
   Rodrigus, I
   De Bock, D
   Vergauwen, W
   Stockman, B
AF Moerenhout, K.
   Rodrigus, I.
   De Bock, D.
   Vergauwen, W.
   Stockman, B.
TI Titanium Transverse Plate Fixation : a New Solution for Old Sternal
   Problems
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE Titanium transverse plate fixation; sternal wound infection;
   mediastinitis; sternal instability
ID RISK-FACTORS; MEDIASTINITIS; FLAP; COMPLICATIONS; INFECTIONS;
   STERNOTOMY; OMENTUM
AB Objective : To evaluate our initial results with the titanium transverse plate fixation system of the sternum in four patients.
   Methods : Two patients with late dehiscence and persistent instability of the sternum after cardiac surgery were treated with refixation by titanium transverse plates and screws. Two patients were treated with the same refixation method after pre-treatment with debridement, antibiotic therapy and vacuum-assisted closure therapy for extensive mediastinitis.
   Results : All four patients heated without complications. The mean postoperative length of stay was 17,3 days (range 744). The instability and/or pain disappeared in all patients. The postoperative imaging showed good positioning of the osteosynthesis material. There was no re-infection in patients with mediastinitis.
   Conclusions : The titanium transverse plate fixation system is a very promising adjunct to the armamentarium of the cardio-thoracic surgeon for treatment of sternal problems, including dehiscence and fractures, even when mediastinitis is involved. It offers more stability compared to simple rewiring, without the need for extensive retrosternal dissection.
C1 [Moerenhout, K.; Rodrigus, I.; De Bock, D.; Vergauwen, W.; Stockman, B.] Univ Antwerp Hosp, Dept Cardiac Surg, B-2650 Edegem, Belgium.
C3 University of Antwerp
RP Rodrigus, I (通讯作者)，Univ Antwerp Hosp, Dept Cardiac Surg, Wilrijkstr 10, B-2650 Edegem, Belgium.
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NR 20
TC 3
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD JUN
PY 2009
VL 109
IS 3
BP 371
EP 375
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 499BQ
UT WOS:000270191900018
PM 19943595
DA 2026-07-24
ER

PT J
AU Tipton, AM
   Cohen, SA
   Chelmow, D
AF Tipton, Amanda M.
   Cohen, Stephen A.
   Chelmow, David
TI Wound Infection in the Obese Pregnant Woman
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE obesity; cesarean delivery; wound infection; wound seroma; wound
   hematoma; cellulitis
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTION; RISK-FACTORS; CESAREAN
   DELIVERY; DISRUPTION; RECLOSURE; INCISIONS; REDUCE
AB Obesity has been linked as a risk factor for wound complications and is becoming a more common occurrence. We reviewed the risk factors, preventive strategies, and recommended management of wound complications in obese women undergoing cesarean delivery. The limited available data support the use of prophylactic antibiotic before cesarean delivery, closure of subcutaneous space >2 cm, and maintaining normothermia intraoperatively to help reduce the incidence of postoperative wound complications. Data regarding management of cesarean wound complications in the obese patient are sparse, but they do suggest either primary or secondary closure of wounds is preferred to healing by secondary intention. Antibiotics should be administered in the presence of cellulitis or systemic toxicity. Use of vacuum-assisted wound closure devices may be useful in wound management. There is a need for randomized controlled trials which evaluate the prevention and management of wound complications in obese women undergoing cesarean delivery. Semin Perinatol 35:345-349 (C) 2011 Elsevier Inc. All rights reserved.
C1 [Tipton, Amanda M.; Cohen, Stephen A.; Chelmow, David] Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Chelmow, D (通讯作者)，Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, POB 9800034, Richmond, VA 23298 USA.
EM dchelmow@mcvh-vcu.edu
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NR 31
TC 27
Z9 29
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD DEC
PY 2011
VL 35
IS 6
BP 345
EP 349
DI 10.1053/j.semperi.2011.05.020
PG 5
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA 858VQ
UT WOS:000297831700007
PM 22108085
DA 2026-07-24
ER

PT J
AU Keel, M
   Trentz, O
AF Keel, M
   Trentz, O
TI Acute management of pelvic ring fractures
SO CURRENT ORTHOPAEDICS
LA English
DT Article; Proceedings Paper
CT 71st Annual Meeting of the American-Academy-of-Orthopaedic-Surgeons
CY MAR 10-14, 2004
CL San Francisco, CA
SP Amer Acad Orthopaed Surg
DE pelvic ring fracture; life-saving surgery; damage control; pelvic
   C-clamp; pelvic packing; angiographic embolisation; second took;
   vacuum-assisted closure; early total care; delayed definitive surgery
ID DAMAGE-CONTROL; LAPAROTOMY; HEMORRHAGE
AB During the primary survey, patients with pelvic ring fractures undergo decision making for day 1 surgery including life-saving surgery, damage control surgery and early total care or delayed definitive surgery dependent on haemodynamic status, physiologic criteria (hypothermia, coagulopathy, acidosis), scoring of injury severity and personal or operative resources. The staged sequential procedures of 'pelvic damage control' include damage control surgery with control of haemorrhage and contamination, decompression of abdominal and pelvic compartment syndromes, debridement of soft tissue injuries as well as temporary or definitive osteosynthesis, followed by resuscitation in the intensive care unit, 'second-look' operations, scheduled definitive surgery and secondary reconstructive surgery. External fixation of the posterior pelvic ring by pelvic C-clamp and pelvic packing represent the work horses for haemorrhage control of severe pelvic ring injuries in haemodynamically unstable patients, whereas angiographic embolisation is an option for haemodynamically stable patients or persistent bleeding after or during damage control surgery. (C) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Zurich Hosp, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Keel, M (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM marius.keel@u.sz.ch; otmar.trentz@usz.ch
CR *ADV TRAUM LIF SUP, 1997, INSTR COURS MAN
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NR 20
TC 3
Z9 4
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-0890
J9 CURR ORTHOPAED
JI Curr. Orthop.
PD OCT
PY 2005
VL 19
IS 5
BP 334
EP 344
DI 10.1016/j.cuor.2005.09.009
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA 989IM
UT WOS:000233666100002
DA 2026-07-24
ER

PT J
AU Baldwin, C
   Potter, M
   Clayton, E
   Irvine, L
   Dye, J
AF Baldwin, Christopher
   Potter, Matthew
   Clayton, Elizabeth
   Irvine, Laurie
   Dye, Julian
TI Topical Negative. Pressure Stimulates Endothelial Migration and
   Proliferation A Suggested Mechanism for Improved Integration of Integra
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 12th Congress of the British-Burns-Association
CY 2006
CL Dublin, IRELAND
SP British Burns Assoc
DE topical negative pressure; angiogenesis; wound healing; synthetic dermal
   equivalents
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION TEMPLATE; SUBATMOSPHERIC
   PRESSURE; EXTRACELLULAR-MATRIX; ARTIFICIAL SKIN; CLINICAL-TRIAL; TISSUE
   DEFECTS; WOUND CONTROL; ANGIOGENESIS; THERAPY
AB Topical negative pressure is an effective technique to promote wound healing and the integration of skin graft and synthetic dermal equivalents. We describe an in vitro model to investigate the effect of negative pressure on angiogenesis, a pivotal step. Dermal fibroblasts or human microvascular endothelial cells were cultured on Integra and subjected to intermittent or continuous negative pressure. At fixed intervals of over 120 hours, the Integra was fixed and assessed for cell migration (microscopy), cell viability (MTS assay), and cell proliferation (Ki67 immunostaining). Under control conditions, endothelial cells formed a monolayer and failed to ingress, whereas fibroblasts migrated throughout the Integra within 24 hours. Negative pressure switches endothelial cell to a migratory and proliferative phenotype. Ingress is greatest with intermittent rather than continuous negative pressure. It has no effect on dermal fibroblast function. This study identifies an important, potential pro-angiogenic mechanism by which topical negative pressure promotes wound healing.
C1 [Baldwin, Christopher; Potter, Matthew; Clayton, Elizabeth; Dye, Julian] Mt Vernon Hosp, Inst Plast Surg, RAFT, Northwood HA6 2RN, Middx, England.
   [Irvine, Laurie] Watford Dist Gen Hosp, Watford, England.
C3 Watford General Hospital
RP Dye, J (通讯作者)，Mt Vernon Hosp, Inst Plast Surg, RAFT, Northwood HA6 2RN, Middx, England.
EM dyej@raft.ac.uk
RI Dye, Julian Francis/U-3396-2019; Potter, Matthew/JFK-2500-2023
OI Dye, Julian Francis/0000-0001-7634-2822; 
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NR 30
TC 64
Z9 85
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2009
VL 62
IS 1
BP 92
EP 96
DI 10.1097/SAP.0b013e31817762fd
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 388NH
UT WOS:000262026000023
PM 19131729
DA 2026-07-24
ER

PT J
AU Kopechek, KJ
   Patel, HV
   Koch, GE
AF Kopechek, Kyle J.
   Patel, Hiren V.
   Koch, George E.
TI Modern Management of Fournier's Gangrene
SO CURRENT UROLOGY REPORTS
LA English
DT Review
DE Fournier's gangrene; Necrotizing soft tissue infection; Skin-sparing
   debridement; Wound care; Genital reconstruction; Wound closure
ID SOFT-TISSUE INFECTIONS; VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN;
   INTRAVENOUS IMMUNOGLOBULIN; SKIN; RECONSTRUCTION; MORTALITY; DIAGNOSIS;
   ETIOLOGY; OUTCOMES
AB Purpose of reviewThis review explores new evidence in Fournier's Gangrene management, emphasizing survivorship. We highlight the shift toward skin-sparing debridement techniques, new reconstructive strategies, and highlight limited evidence on outcomes. Additionally, we examine recent evidence on diagnosis, antimicrobial therapy, adjunctive treatments, and post-operative wound care.Recent findingsNew evidence supports the feasibility of skin-sparing debridement, reducing the need for extensive reconstruction while improving primary closure rates and lowering healthcare costs. Advances in reconstructive techniques accelerate wound healing and shorten hospital stays. Optimized wound management-integrating antimicrobial solutions, negative pressure therapy, and targeted antibiotics-continues to improve recovery while minimizing morbidity and mortality.SummaryModern Fournier's management prioritizes early recognition, tissue preservation, and early genital reconstruction. Despite advancements, gaps remain in early diagnosis and long-term outcomes after the index admission. Further research on post-reconstruction recovery is essential to refine treatment protocols and determine quality of life for affected patients.
C1 [Kopechek, Kyle J.; Patel, Hiren V.; Koch, George E.] Ohio State Univ, Wexner Med Ctr, Dept Urol, 915 Olentangy River Rd,Suite 3117, Columbus, OH 43212 USA.
   [Koch, George E.] Univ Washington, Dept Urol, Seattle, WA USA.
C3 University System of Ohio; Ohio State University; University of
   Washington; University of Washington Seattle
RP Kopechek, KJ (通讯作者)，Ohio State Univ, Wexner Med Ctr, Dept Urol, 915 Olentangy River Rd,Suite 3117, Columbus, OH 43212 USA.
EM Kyle.Kopechek@osumc.edu
OI Patel, Hiren/0000-0002-6475-670X
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NR 74
TC 8
Z9 10
U1 8
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1527-2737
EI 1534-6285
J9 CURR UROL REP
JI Curr. Urol. Rep.
PD JUN 2
PY 2025
VL 26
IS 1
AR 47
DI 10.1007/s11934-025-01275-3
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 3HM0H
UT WOS:001500450200001
PM 40455358
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Zhou, EH
   Liu, SR
   Zhu, HM
   Yi, HL
   Chen, XP
AF Zhou, En-hui
   Liu, Su-ru
   Zhu, Hua-ming
   Yi, Hong-liang
   Chen, Xiao-ping
TI Management and postoperative use of double-cannula irrigation-drainage
   tube in cervical necrotizing fasciitis: a Chinese single-institution
   experience of 46 patients
SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
LA English
DT Article
DE Cervical necrotizing fasciitis; Experience; Management; Therapeutic
   approach; Double-cannula irrigation-drainage
ID VACUUM-ASSISTED CLOSURE; RETROSPECTIVE ANALYSIS; HYPERBARIC-OXYGEN;
   NEGATIVE-PRESSURE; NECK; HEAD; THERAPY
AB Purpose This study aimed to analyze a Chinese institution's experience with managing cervical necrotizing fasciitis (CNF) and observe the effects of a new therapeutic approach for postoperative drainage system. Methods A retrospective study was established including a total of 46 CNF patients who underwent surgical debridement between April 2006 and April 2018. Analyses of demographic data, etiology, comorbidity, microbiology, complications, treatment methods, duration of treatment, and treatment outcomes were obtained. Results There were 16 kinds of microbes cultured in 29 patients. Diabetic patients were more commonly infected by microbes (P < 0.05). There was a significant reduction in the number of operative time (P < 0.05) and length of hospitalization (P < 0.01) with postoperative therapy of double-cannula irrigation-drainage (DCID) system. Conclusion CNF management includes controlling for comorbidities especially glycemic control and reasonable utilization of antibiotics and aggressive postoperative therapy. DCID system can effectively reduce operative frequency and duration of hospitalization.
C1 [Zhou, En-hui; Chen, Xiao-ping] Pudong New Area Gongli Hosp, Dept Otorhinolaryngol, Shanghai, Peoples R China.
   [Zhou, En-hui; Liu, Su-ru; Zhu, Hua-ming; Yi, Hong-liang] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Otorhinolaryngol, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Chen, XP (通讯作者)，Pudong New Area Gongli Hosp, Dept Otorhinolaryngol, Shanghai, Peoples R China.
EM chen_xp2000@163.com
RI Zhou, Enhui/JZE-8170-2024
OI Chen, Xiao-Ping/0000-0003-3048-2699
FU Key Specialty Construction Project of Health Bureau of Shanghai
   [ZK2019C06]; Key Disciplines Group Construction Project of Pudong Health
   Bureau of Shanghai [PWZxq2017-04]; Young Fundation of Pudong Gongli
   Hospital of Shanghai [2018YQNJJ-05]
FX This work was supported by a grant from the Key Specialty Construction
   Project of Health Bureau of Shanghai (Grant No. ZK2019C06), the Key
   Disciplines Group Construction Project of Pudong Health Bureau of
   Shanghai (PWZxq2017-04), the Young Fundation of Pudong Gongli Hospital
   of Shanghai (Grant No. 2018YQNJJ-05).
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NR 30
TC 5
Z9 6
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0937-4477
EI 1434-4726
J9 EUR ARCH OTO-RHINO-L
JI Eur. Arch. Oto-Rhino-Laryn.
PD AUG
PY 2021
VL 278
IS 8
BP 2975
EP 2981
DI 10.1007/s00405-020-06424-7
EA OCT 2020
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA TJ3KH
UT WOS:000579732500002
PM 33078259
DA 2026-07-24
ER

PT J
AU Tomic-Canic, M
   Wong, LLL
   Smola, H
AF Tomic-Canic, Majana
   Wong, Lulu L.
   Smola, Hans
TI The epithelialisation phase in wound healing: options to enhance wound
   closure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE epithelialisation; growth factors; proteases; skin grafting; skin
   substitutes
ID FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; ADULT HUMAN
   KERATINOCYTES; COLONY-STIMULATING FACTOR; SKIN CELL-MIGRATION;
   FACTOR-ALPHA; MITOGENIC ACTIVITY; LEG ULCERS; TGF-ALPHA; TEMPORAL
   EXPRESSION
AB This review highlights epithelialisation and therapeutic options to optimise and speed the epithelialisation process. To influence this process therapeutically, it is important for clinicians to understand the underlying principles of epithelialisation. The role of growth factors and the hostile local wound environment can explain why epithelial wound closure is so difficult to speed up in some chronic wounds. Clinicians should be aware of the different surgical techniques of skin grafting and more advanced technologies, such as skin substitutes, as options for wounds which fail to respond to standard protocols. Finally, novel dressing-based concepts are discussed, including macromolecular crowding, a concept which aims at boosting growth factor activities produced in the wound space once wound healing is normalised and underway.
   Declaration of interest: HS is a full-time employee of PAUL HARTMANN, a medical device manufacturer. MT-C has no conflict of interest to declare relating to this paper.
C1 [Tomic-Canic, Majana] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Wound Healing & Regenerat Med Res Program,Res, Miami, FL 33136 USA.
   [Tomic-Canic, Majana; Wong, Lulu L.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Wound Healing & Regenerat Med Res Program, Miami, FL 33136 USA.
   [Smola, Hans] PAUL HARTMANN AG, Dermatol, Heidenheim, Germany.
   [Smola, Hans] Univ Cologne, Dept Dermatol, Cologne, Germany.
C3 University of Miami; University of Miami; University of Cologne
RP Smola, H (通讯作者)，PAUL HARTMANN AG, Dermatol, Heidenheim, Germany.; Smola, H (通讯作者)，Univ Cologne, Dept Dermatol, Cologne, Germany.
EM hans.smola@hartmann.info
OI Tomic-Canic, Marjana/0000-0002-9341-0193
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NR 155
TC 19
Z9 23
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2018
VL 27
IS 10
BP 646
EP 658
DI 10.12968/jowc.2018.27.10.646
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GX3RJ
UT WOS:000447644200002
PM 30332358
DA 2026-07-24
ER

PT J
AU Wang, GF
   Ren, JA
   Liu, S
   Wu, XW
   Gu, GS
   Li, JS
AF Wang, Gefei
   Ren, Jianan
   Liu, Song
   Wu, Xiuwen
   Gu, Guosheng
   Li, Jieshou
TI "Fistula patch": Making the treatment of enteroatmospheric fistulae in
   the open abdomen easier
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Enteroatmospheric fistulae; patch; open abdomen; enteral nutrition
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; FASCIAL
   CLOSURE; MANAGEMENT
AB BACKGROUND: It remains an extreme challenge in clinical practice to manage the enteroatmospheric fistula (EAF), which is a severer complication after abdominal opening. In current literature, several methods have been established, generally focusing on controlling fistula effluent and keeping the wound bed clean. However, the loss of enteric fistula effluent would potentially lead to a risk of the disturbance of internal environment and malnutrition.
   METHODS: We designed an innovative "fistula patch" technique for protecting open abdominal wounds from being contaminated by intestinal fistulae drainages and simultaneously applying enteral nutrition.
   RESULTS: Eleven patients with single EAF were treated with fistula patch technique. Enteral nutrition was then administrated successfully until the definite surgery.
   CONCLUSION: The fistula patch technique is a simple, effective, and inspiring method to control EAF, as it brings together the benefits of avoiding the loss of enteric fistula effluent, simplifying wound management, ceasing tissue destruction, and providing enteral nutrition application. (J Trauma Acute Care Surg. 2013;74: 1175-1177. Copyright (C) 2013 by Lippincott Williams & Wilkins)
C1 [Wang, Gefei; Ren, Jianan; Liu, Song; Wu, Xiuwen; Gu, Guosheng; Li, Jieshou] Nanjing Univ, Sch Med, Jinling Hosp, Dept Surg, Nanjing 210008, Jiangsu, Peoples R China.
C3 Nanjing University
RP Ren, JA (通讯作者)，Jinling Hosp, Dept Surg, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
EM jiananr@gmail.com
RI ; Wu, Xiuwen/AEO-0814-2022
OI LIU, SONG/0000-0002-4780-9697; Ren, Jianan/0000-0002-7978-8093; Wu,
   Xiuwen/0000-0002-3813-3867
FU Advanced Training Program for Talents, Jiangsu Province, China
   [BRA2011232]; National Natural Science Foundation of China [81270478]
FX This work was supported by a grant from the Advanced Training Program
   for Talents, Jiangsu Province, China (grant no. BRA2011232), and the
   National Natural Science Foundation of China (grant no. 81270478).
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NR 12
TC 19
Z9 27
U1 0
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD APR
PY 2013
VL 74
IS 4
BP 1175
EP 1177
DI 10.1097/TA.0b013e318282705e
PG 3
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 123SS
UT WOS:000317411700038
PM 23511162
DA 2026-07-24
ER

PT J
AU Medas, R
   Rodrigues-Pinto, E
AF Medas, Renato
   Rodrigues-Pinto, Eduardo
TI Technical Review on Endoscopic Treatment Devices for Management of Upper
   Gastrointestinal Postsurgical Leaks
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID EXPANDABLE METAL STENTS; VACUUM-ASSISTED CLOSURE; THE-SCOPE-CLIP;
   ESOPHAGEAL ANASTOMOTIC LEAK; STAPLE LINE LEAKS; UPPER GI LEAKS; SLEEVE
   GASTRECTOMY; BARIATRIC SURGERY; MULTICENTER EXPERIENCE; INTERNAL
   DRAINAGE
AB Upper gastrointestinal postsurgical leaks are challenging to manage and often require radiological, endoscopic, or surgical intervention. Nowadays, endoscopy is considered the first-line approach for their management, however, there is no definite consensus on the most appropriate therapeutic approach. There is a wide diversity of endoscopic options, from close-cover-divert approaches to active or passive internal drainage approaches. Theoretically, all these options can be used alone or with a multimodality approach, as each of them has different mechanisms of action. The approach to postsurgical leaks should always be tailored to each patient, taking into account the several variables that may influence the final outcome. In this review, we discuss the important developments in endoscopic devices for the treatment of postsurgical leaks. Our discussion specifically focuses on principles and mechanism of action, advantages and disadvantages of each technique, indications, clinical success, and adverse events. An algorithm for endoscopic approach is proposed.
C1 [Medas, Renato; Rodrigues-Pinto, Eduardo] Ctr Hosp Sao Joao, Gastroenterol Dept, Porto, Portugal.
   [Medas, Renato; Rodrigues-Pinto, Eduardo] Univ Porto, Fac Med, Porto, Portugal.
C3 Sao Joao Hospital; Universidade do Porto
RP Rodrigues-Pinto, E (通讯作者)，Ctr Hosp Sao Joao, Gastroenterol Dept, Porto, Portugal.; Rodrigues-Pinto, E (通讯作者)，Univ Porto, Fac Med, Porto, Portugal.
EM renatogmedas@gmail.com; edu.gil.pinto@gmail.com
RI ; Medas, Renato/JVD-9364-2023
OI Rodrigues-Pinto, Eduardo/0000-0002-2239-1650; Medas,
   Renato/0000-0002-1892-2666
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NR 115
TC 4
Z9 5
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PD JUN 12
PY 2023
VL 2023
AR 9712555
DI 10.1155/2023/9712555
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA K4CK3
UT WOS:001015931000001
PM 37342388
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bas, A
   Aslan, L
   Eralp, IL
AF Bas, Ali
   Aslan, Lercan
   Eralp, Ibrahim Levent
TI Undifferentiated pleomorphic sarcoma of skin in unusual locations:
   Report of two cases
SO JOINT DISEASES AND RELATED SURGERY
LA English
DT Article
DE Dermatologic oncology; ultraviolet exposure; undifferentiated
   pleomorphic sarcoma
ID SOFT-TISSUE
AB Undifferentiated pleomorphic sarcoma (UPS) of the skin is a rare soft tissue sarcoma subtype with a high risk of metastasis and local recurrence. Ultraviolet exposure plays a prominent role in its etiology. Herein, we present two rare cases of UPS of the skin with an occurrence in non-ultraviolet exposed locations and discuss the need of wide resection and the identification of the depth of the tumor. Due to the resection of the skin, resulting defect was undertaken with skin grafting. One case was extending to the fascia and, after the resection, vacuum-assisted closure therapy was used for the formation of granulation tissue. No recurrence was seen after three and four years for either cases. In conclusion, UPS is a rare, aggressive malignant tumor with a high local recurrence and metastasis rate. Suspicion of malignancy in a plaque-like or nodular lesion in the skin is crucial, and local recurrence and metastasis risk is significantly correlated to the success of wide excision.
C1 [Bas, Ali; Aslan, Lercan] Koc Univ Hosp, Dept Orthoped & Traumatol, Istanbul, Turkey.
   [Eralp, Ibrahim Levent] Istanbul Univ, Dept Orthoped & Traumatol, Istanbul, Turkey.
C3 Koc University; Istanbul University
RP Aslan, L (通讯作者)，Koc Univ Hastanesi, Ortopedi & Travmatol Bolumu, TR-34010 Istanbul, Turkey.
EM lercan.aslan86@gmail.com
RI Bas, Ali/AAX-3771-2021; Aslan, Lercan/HLQ-0419-2023
OI Bas, Ali/0000-0001-8339-7418; Aslan, Lercan/0000-0003-1358-3236
CR Atik OS, 2019, EKLEM HAST CERRAHISI, V30, P69, DOI 10.5606/ehc.2019.003
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NR 11
TC 2
Z9 3
U1 0
U2 4
PU TURKISH JOINT DISEASES FOUNDATION
PI CANKARA
PA MUSTAFA KEMAL MAHALLESI, DUMLUPINAR BULVARI 274-2 C2 BLOK OFIS, 5,
   CANKARA, ANKARA, TURKEY
SN 2687-4784
EI 2687-4792
J9 JOINT DIS RELAT SURG
JI Joint Dis. Relat. Surg.
PY 2021
VL 32
IS 1
BP 253
EP 257
DI 10.5606/ehc.2021.78856
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA PT2HR
UT WOS:000608440400038
PM 33463447
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kollrack, Y
   Möllenhoff, G
AF Kollrack, Y.
   Moellenhoff, G.
TI Ankle osteosynthesis infection
SO UNFALLCHIRURG
LA German
DT Article
DE Infection; Osteosynthesis; Angiopathy; Ankle fracture; Vacuum therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; FRACTURES;
   COMPLICATIONS
AB Should osteosynthesis infection occur after ankle fractures in patients with microangiopathy, the infection needs to be cured quickly and safely to protect implants, bone, and tendons. Vacuum therapy (TNP) provides a perfect treatment plan that keeps the inpatient time low whilst ensuring high patient comfort.
   Four angiopathic patients with deep wound infection after ankle osteosynthesis were treated. At admission, loss of stability and spread of the infection were the immeadiate risks. To prevent this, we treated the patients with vacuum therapy after initial debridement until skin cover was achieved.
   In all cases stability was secured and after 2 dressing changes, the swabs were sterile. The inpatient time was 13 days; overall vacuum therapy time was 59 days. Patient satisfaction was high.
   Vacuum therapy is a perfect strategy after surgical debridement and before secondary mesh grafting. It protects the stability of the bone and open-lying delicate structures in patients with infected osteosynthesis of the ankle and angiopathy and offers an easy, safe, and successful treatment path with a short inpatient time.
C1 [Kollrack, Y.; Moellenhoff, G.] Raphaelsklin Munster, Abt Unfall & Wiederherstellungschirurg, D-48143 Munster, Germany.
RP Kollrack, Y (通讯作者)，Raphaelsklin Munster, Abt Unfall & Wiederherstellungschirurg, Loerstr 23, D-48143 Munster, Germany.
EM ykollrack@yahoo.de
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NR 31
TC 4
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD APR
PY 2009
VL 112
IS 4
BP 433
EP 438
DI 10.1007/s00113-008-1521-x
PG 6
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 428WY
UT WOS:000264884000013
PM 19283356
DA 2026-07-24
ER

PT J
AU Katoumas, K
   Mitsopoulos, G
AF Katoumas, Konstantinos
   Mitsopoulos, Georgios
TI Vol. 137 No. Vacuum-assisted closure of a tissue deficit of the
   submental area in a patient with a necrotizing soft tissue odontogenic
   infection
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
LA English
DT Article
ID LABORATORY RISK INDICATOR; FASCIITIS; PRESSURE; SCORE; HEAD; NECK
AB Odontogenic infections can rarely progress to necrotizing soft tissue infections. Cervical necrotizing fasciitis (CNF) is a rare but fulminant infection that spreads along the fascial planes, including connective tissue, muscle, and subcutaneous fat, and is typified by necrosis of the skin and other adjacent tissues. This article aims to present the treatment of a patient with submental skin and soft tissue necrosis due to an odontogenic infection and the subsequent management of the tissue deficit with a vacuumassisted closure (VAC) system. The patient presented with extensive skin necrosis in the submental area and was immediately hospitalized, and management of the odontogenic infection was performed. When the patients' infection had been sufficiently controlled, a wound VAC device was placed in the deficit. The VAC device was removed after 12 days, and the patient was discharged. In conclusion, VAC can be used to manage tissue deficits with good aesthetic results. (Oral Surg Oral Med Oral Pathol Oral Radiol 2024;137:e119 -e124)
C1 [Katoumas, Konstantinos] Natl & Kapodistrian Univ Athens, Gen Hosp Athens Evaggelismos, Dept Oral & Maxillofacial Surg, Athens, Greece.
   [Katoumas, Konstantinos] Natl & Kapodistrian Univ Athens, Sch Dent, Athens, Greece.
   [Mitsopoulos, Georgios] 401Gen Mil Hosp Athens, Dept Oral & Maxillofacial Surg, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Katoumas, K (通讯作者)，Natl & Kapodistrian Univ Athens, Gen Hosp Athens Evaggelismos, Dept Oral & Maxillofacial Surg, Athens, Greece.; Katoumas, K (通讯作者)，Natl & Kapodistrian Univ Athens, Sch Dent, Athens, Greece.
EM k_katoumas@hotmail.com
OI Katoumas, Konstantinos/0000-0003-4264-4878
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-4403
EI 2212-4411
J9 OR SURG OR MED OR PA
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
PD JUN
PY 2024
VL 137
IS 6
BP e119
EP e124
DI 10.1016/j.oooo.2023.10.013
EA JUN 2024
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA XS8H2
UT WOS:001263753300001
PM 38155007
DA 2026-07-24
ER

PT J
AU Hinz, B
AF Hinz, B.
TI The role of myofibroblasts in wound healing
SO CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
LA English
DT Article
DE Hypertrophic scar; Chronic wound; Fibrosis; Mechanics
ID LATENT TGF-BETA; TYROSINE KINASE INHIBITOR; MUSCLE ACTIN EXPRESSION;
   VACUUM-ASSISTED CLOSURE; GROWTH-FACTOR; PULMONARY-FIBROSIS;
   GRANULATION-TISSUE; TRANSFORMING GROWTH-FACTOR-BETA-1;
   MOLECULAR-MECHANISMS; EPITHELIAL-CELLS
AB The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury. Too many myofibroblasts working for too long cause tissue contractures that ultimately obstruct organ function. Insufficient myofibroblast activation and activities, in turn, prevents normal wound healing. This short review puts a spotlight on the myofibroblast for those who seek therapeutic targets in the context of dysregulated tissue repair. "Keep your myofibroblasts in balance" is the message. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Hinz, B.] Univ Toronto, Fac Dent, Lab Tissue Repair & Regenerat, Matrix Dynam Grp, 150 Coll St,FitzGerald Bldg,Room 234, Toronto, ON M5S 3E2, Canada.
C3 University of Toronto
RP Hinz, B (通讯作者)，Univ Toronto, Fac Dent, Lab Tissue Repair & Regenerat, Matrix Dynam Grp, 150 Coll St,FitzGerald Bldg,Room 234, Toronto, ON M5S 3E2, Canada.
EM boris.hinz@utoronto.ca
OI Hinz, Boris/0000-0002-0526-393X
FU Canadian Institutes of Health Research (CIHR) [210820, 286920, 286720,
   497202]; Collaborative Health Research Programme (CIHR/NSERC) [1004005,
   413783]; Canada Foundation for Innovation and Ontario Research Fund
   (CFI/ORF) [26653]; National Health and Medical Research Council (NHMRC)
   [1004005] Funding Source: National Health and Medical Research Council
   (NHMRC)
FX The research of BH is supported by Canadian Institutes of Health
   Research (CIHR) ( grants #210820, #286920, #286720, and #497202), the
   Collaborative Health Research Programme (CIHR/NSERC) (grants #1004005
   and #413783), and the Canada Foundation for Innovation and Ontario
   Research Fund (CFI/ORF) (grant #26653).
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NR 158
TC 283
Z9 342
U1 2
U2 36
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 2452-3186
J9 CURR RES TRANSL MED
JI Curr. Res. Transl. Med.
PD OCT-DEC
PY 2016
VL 64
IS 4
BP 171
EP 177
DI 10.1016/j.retram.2016.09.003
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FO4AW
UT WOS:000416782900003
PM 27939455
DA 2026-07-24
ER

PT J
AU Lachenbruch, C
   VanGilder, C
AF Lachenbruch, Charlie
   VanGilder, Catherine
TI Estimates of Evaporation Rates from Wounds for Various Dressing/Support
   Surface Combinations
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE exudate management; wound dressings and moisture vapor transmission;
   microclimate management and wound; support surfaces; pressure ulcers;
   pressure ulcer treatment; evaporative capacity; sweating guarded hot
   plate
ID SKIN
AB The management of exudate is an essential aspect of wound care. The wound bed must remain moist to promote healing, but care must be taken to remove excess fluid to avoid maceration and subsequent breakdown of the periwound site, which could serve as a possible portal to infection. Excess fluid is typically absorbed into and/or evaporates through the wound dressing or may be managed by a powered vacuum-assisted closure device. Although the moisture vapor permeability has been studied for dressings, the rate of evaporation associated with the wound's immediate treatment environment, or dressing/treatment surface interface, has not been addressed to date. It is essential for caregivers to have an understanding of how these 2 interventions work together in order to provide optimal care to the wound patient. The purpose of this study was to provide estimates of evaporative withdrawal rates for various wound dressings and therapeutic support surfaces.
C1 [Lachenbruch, Charlie; VanGilder, Catherine] Hill Rom, Clin Res, Batesville, IN USA.
RP Lachenbruch, C (通讯作者)，Hill Rom, Clin Res, Batesville, IN USA.
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NR 23
TC 5
Z9 5
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-7941
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2012
VL 25
IS 1
BP 29
EP 36
DI 10.1097/01.ASW.0000410688.21987.1d
PG 8
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 876MD
UT WOS:000299110700006
PM 22218068
DA 2026-07-24
ER

PT J
AU Hua, F
   Sun, DF
   Zhao, XM
   Song, XM
   Yang, WF
AF Hua, Feng
   Sun, Dongfeng
   Zhao, Xiaoming
   Song, Xuemin
   Yang, Wenfeng
TI Update on therapeutic strategy for esophageal anastomotic leak: A
   systematic literature review
SO THORACIC CANCER
LA English
DT Review
DE anastomotic leakage; esophageal carcinoma; esophagectomy; esophagus;
   fistula
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; ENDOSCOPIC STENT
   INSERTION; GASTROPERICARDIAL FISTULA; ESOPHAGOTRACHEAL FISTULA;
   SURGICAL-TREATMENT; METAL STENT; BLOOD-FLOW; COMPLICATION; FLAP
AB Anastomotic leak is still a severe complication in esophageal surgery due to high mortality. This article reviews the updates on the treatment of anastomotic leak after esophagectomy in order to provide reference for clinical treatment and research. The relevant studies published in the Chinese Zhiwang, Wanfang, and MEDLINE databases to December 21, 2021 were retrieved, and esophageal carcinoma, esophagectomy, anastomotic leakage, and fistula selected as the keywords. A total of 78 studies were finally included. The treatments include traditional surgical drainage, new reverse drainage trans-fistula, stent plugging, endoscopic clamping, biological protein glue injection plugging, endoluminal vacuum therapy (EVT), and reoperation, etc. Early diagnosis, accurate classification and optimal treatment can promote the rapid healing of anastomotic leaks. EVT may be the most valuable approach, simultaneously with good commercial prospects. Reoperation should be considered in patients with complex fistula in which conservative treatment is insufficient or has failed.
C1 [Hua, Feng; Sun, Dongfeng; Zhao, Xiaoming; Song, Xuemin; Yang, Wenfeng] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Thorac Surg, Jinan, Peoples R China.
   [Yang, Wenfeng] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Thorac Surg, Jiyan Rd 440, Jinan, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Yang, WF (通讯作者)，Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Thorac Surg, Jiyan Rd 440, Jinan, Peoples R China.
EM lwyangwf@163.com
FU Foundation of Development Center for Medical Science and Technology,
   National Health Commission of the People' Republic of China; 
   [WA2021RW03]
FX ACKNOWLEDGMENTS This work was supported by the Foundation of Development
   Center for Medical Science and Technology, National Health Commission of
   the People' Republic of China (WA2021RW03).
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NR 78
TC 21
Z9 25
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1759-7706
EI 1759-7714
J9 THORAC CANCER
JI Thorac. Cancer
PD FEB
PY 2023
VL 14
IS 4
BP 339
EP 347
DI 10.1111/1759-7714.14734
EA DEC 2022
PG 9
WC Oncology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Respiratory System
GA 8D0TO
UT WOS:000898048100001
PM 36524684
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hu, H
   Zou, W
   Luo, XQ
   Yu, SJ
   Wang, JW
   Hu, XL
   Yu, F
   Ji, R
AF Hu, Hang
   Zou, Wen
   Luo, Xiaoqian
   Yu, Shaojun
   Wang, Jianwei
   Hu, Xinlei
   Yu, Feng
   Ji, Ran
TI Case Report: Multidisciplinary collaboration for the treatment of severe
   necrotizing fasciitis in the perineum caused by rectal cancer
   perforation
SO FRONTIERS IN SURGERY
LA English
DT Article
DE Fournier's gangrene; multidisciplinary care; patient-centered care;
   rectal cancer perforation; staged surgical management
ID FOURNIERS GANGRENE; MORTALITY
AB Fournier's gangrene (FG) is a rare but life-threatening necrotizing fasciitis of the perineum and genital regions. Rectal cancer perforation is an uncommon cause of FG, and optimal management remains challenging. Case presentation: We report a 62-year-old male with rectal cancer complicated by severe FG secondary to rectal perforation. The patient underwent emergency fecal diversion, repeated extensive perineal debridement combined with vacuum-assisted closure (VAC) therapy, and intensive supportive care. Following infection control and clinical stabilization, definitive surgical management was performed, including laparoscopic abdominoperineal resection and reconstruction of the large perineal defect using a vascularized gracilis muscle flap and a gluteus maximus fascia composite flap. At two-month follow-up, the patient demonstrated complete wound healing, stable colostomy function, and recovery of independent daily activities. Conclusions: This case highlights the complexity of managing FG associated with rectal cancer perforation and demonstrates the feasibility of sequential treatment strategies integrating infection control, oncologic resection, and reconstructive surgery.
C1 [Hu, Hang; Zou, Wen] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou, Zhejiang, Peoples R China.
   [Luo, Xiaoqian; Ji, Ran] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg, Hangzhou 310009, Zhejiang, Peoples R China.
   [Yu, Shaojun; Wang, Jianwei; Yu, Feng] Zhejiang Univ, Affiliated Hosp 2,China Natl Minist Educ, Key Lab Canc Prevent & Intervent,Sch Med, Dept Colorectal Surg & Oncol, Hangzhou, Zhejiang, Peoples R China.
   [Yu, Shaojun; Wang, Jianwei; Yu, Feng] Minist Educ, Ctr Med Res & Innovat Digest Syst Tumors, Hangzhou, Peoples R China.
   [Hu, Xinlei] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University
RP Ji, R (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg, Hangzhou 310009, Zhejiang, Peoples R China.
EM 2320052@zju.edu.cn
FU Young Scientists Fund of the National Natural Science Foundation of
   China [82100807]
FX The author(s) declared that financial support was received for this work
   and/or its publication. The research was supported by the Young
   Scientists Fund of the National Natural Science Foundation of China,
   82100807.
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NR 10
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 15
PY 2026
VL 13
AR 1790699
DI 10.3389/fsurg.2026.1790699
EA MAY 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IS1SS
UT WOS:001779046000001
PM 42222220
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Geris, L
   Schugart, R
   Van Oosterwyck, H
AF Geris, L.
   Schugart, R.
   Van Oosterwyck, H.
TI In silico design of treatment strategies in wound healing and
   bone fracture healing
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL
   AND ENGINEERING SCIENCES
LA English
DT Article; Proceedings Paper
CT 4th International Congress on Computational Bioengineering/1st European
   Symposium on Biomedical Integrative Research
CY SEP 16-18, 2009
CL Bertinoro, ITALY
DE wound healing; bone regeneration; mathematical modelling; treatment
   strategies; patient variability
ID VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN THERAPY; GROWTH-FACTOR
   EXPRESSION; MATHEMATICAL-MODEL; DISTRACTION OSTEOGENESIS; TISSUE
   DIFFERENTIATION; MORPHOGENETIC PROTEIN; SURGICAL-TREATMENT;
   CLINICAL-TRIALS; FOOT ULCER
AB Wound and bone fracture healing are natural repair processes initiated by trauma. Over the last decade, many mathematical models have been established to investigate the healing processes in silico, in addition to ongoing experimental work. In recent days, the focus of the mathematical models has shifted from simulation of the healing process towards simulation of the impaired healing process and the in silico design of treatment strategies. This review describes the most important causes of failure of the wound and bone fracture healing processes and the experimental models and methods used to investigate and treat these impaired healing cases. Furthermore, the mathematical models that are described address these impaired healing cases and investigate various therapeutic scenarios in silico. Examples are provided to illustrate the potential of these in silico experiments. Finally, limitations of the models and the need for and ability of these models to capture patient specificity and variability are discussed.
C1 [Geris, L.; Van Oosterwyck, H.] Katholieke Univ Leuven, Div Biomech & Engn Design, Dept Mech Engn, B-3001 Louvain, Belgium.
   [Geris, L.; Van Oosterwyck, H.] Katholieke Univ Leuven, Div Skeletal Tissue Engn, B-3000 Louvain, Belgium.
   [Geris, L.] Univ Liege, Biomech Res Unit, B-4000 Cointe Ougree, Belgium.
   [Schugart, R.] Western Kentucky Univ, Dept Math & Comp Sci, Bowling Green, KY 42101 USA.
C3 KU Leuven; KU Leuven; University of Liege; Western Kentucky University
RP Geris, L (通讯作者)，Katholieke Univ Leuven, Div Biomech & Engn Design, Dept Mech Engn, Celestijnenlaan 300C 2419, B-3001 Louvain, Belgium.
EM liesbet.geris@ulg.ac.be
RI geris, liesbet/D-2343-2016; Van Oosterwyck, Hans/C-2528-2016
OI geris, liesbet/0000-0002-8180-1445; Van Oosterwyck,
   Hans/0000-0002-2142-9717
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NR 154
TC 22
Z9 24
U1 0
U2 9
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1364-503X
EI 1471-2962
J9 PHILOS T R SOC A
JI Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci.
PD JUN 13
PY 2010
VL 368
IS 1920
BP 2683
EP 2706
DI 10.1098/rsta.2010.0056
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Science & Technology - Other Topics
GA 590EN
UT WOS:000277207300007
PM 20439269
DA 2026-07-24
ER

PT J
AU Luce, EA
   Hollier, LH
   Lin, SJ
AF Luce, Edward A.
   Hollier, Larry H., Jr.
   Lin, Samuel J.
TI Plastic Surgeons and the Management of Trauma: From the JFK
   Assassination to the Boston Marathon Bombing
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID TRIAL COMPARING POLYGLACTIN-910-MESH; MULTIPLE-CASUALTY INCIDENTS;
   TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; MASS-CASUALTY;
   TRACHEAL REPLACEMENT; TERRORIST BOMBINGS; RECONSTRUCTION; DISASTER;
   DEFECTS
AB The fiftieth anniversary of the death by assassination of President John Kennedy is an opportunity to pay homage to his memory and also reflect on the important role plastic surgeons have played in the management of trauma. That reflection included a hypothetical scenario, a discussion of the surgical treatment of Kennedy (if he survived) and Governor Connally. The scenario describes the management of cranioplasty in the presence of scalp soft-tissue contracture, reconstruction of the proximal trachea, reconstitution of the abdominal wall, and restoration of a combined radius and soft-tissue defect. The development of diagnostic and therapeutic advances over the past 50 years in the care of maxillofacial trauma is described, including the evolution of imaging, timing of surgery, and operative techniques. Finally, contemporary measures of triage in situations involving mass casualties, as in the Boston Marathon bombings, complete the dedication to President Kennedy.
C1 Univ Tennessee, Hlth Sci Ctr, Knoxville, TN 37996 USA.
   Baylor Coll Med, Houston, TX 77030 USA.
   Beth Israel Deaconess Med Ctr, Boston, MA USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; Baylor College of Medicine; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center
RP Luce, EA (通讯作者)，7945 Wolf River Blvd,Suite 290, Germantown, TN 38138 USA.
EM edluce@yahoo.com
RI Lin, Samuel/P-6158-2019
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NR 49
TC 6
Z9 7
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2013
VL 132
IS 5
BP 1330
EP 1339
DI 10.1097/PRS.0b013e3182a7094c
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 293RI
UT WOS:000329991000078
PM 24165614
DA 2026-07-24
ER

PT J
AU Hess, CL
   Howard, MA
   Attinger, CE
AF Hess, CL
   Howard, MA
   Attinger, CE
TI A review of mechanical adjuncts in wound healing: Hydrotherapy,
   ultrasound, negative pressure therapy, hyperbaric oxygen, and
   electrostimulation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CLINICAL-TRIAL; DOUBLE-BLIND;
   ELECTRICAL-STIMULATION; SKIN ULCERS; ELECTROMAGNETIC-FIELDS; DOSE
   ULTRASOUND; VENOUS ORIGIN; HIGH-VOLTAGE; LEG ULCERS
AB Chronic or non-healing wounds may develop in the setting of many diseases and are the source of considerable morbidity as well as health costs. These wounds demand an aggressive, multifactorial approach including surgical debridement, revascularization, antibiotics and dressings. In addition serveral adjuvant treatment methods have been developed to further stimulate healing. Whirlpool, although used frequently, has not been proven to be of benefit. However, pulsed lavage does show a promising future. Ultrasound has demonstrated beneficial effects but further controlled studies are needed. Subatmospheric pressure therapy is associated with few complications and is fast becoming a mainstay of adjuvant therapy. Hyperbaric oxygen therapy has been shown to be effective for many types of wounds. Unfortunately, cost and access to chambers may prohibit its use on a routine basis. Finally, electrostimulation may be one of the up and coming therapies for the future. Though, more studies are needed to determine the mode of delivery for various types of wounds.
C1 Georgetown Univ Hosp, Div Plast Surg, Washington, DC 20007 USA.
C3 Georgetown University
RP Hess, CL (通讯作者)，3800 Reservoir Rd NW,1st Floor,PHC Bldg, Washington, DC 20007 USA.
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NR 81
TC 99
Z9 122
U1 0
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2003
VL 51
IS 2
BP 210
EP 218
DI 10.1097/01.SAP.0000058513.10033.6B
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 714LN
UT WOS:000184915900018
PM 12897528
DA 2026-07-24
ER

PT J
AU Pop, IC
   Ilies, RA
   Baican, C
   Strilciuc, S
   Muntean, V
   Muntean, M
AF Pop, Ioan Constantin
   Ilies, Radu Alexandru
   Baican, Corina
   Strilciuc, Stefan
   Muntean, Valentin
   Muntean, Maximilian
TI Pyoderma Gangrenosum Post-Breast Surgery: A Case Report and
   Comprehensive Review of Management Strategies
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE pyoderma gangrenosum; breast surgery; management strategies; autoimmune
   skin conditions
ID DIAGNOSIS; RECONSTRUCTION
AB Background/Objectives: Pyoderma gangrenosum (PG) is a rare, autoimmune skin condition characterized by painful, rapidly progressing ulcers, often associated with autoimmune dysregulation. Managing PG following breast surgery presents unique challenges due to its pathergy phenomenon, which complicates surgical interventions. This article outlines the case of PG in a 48-year-old female post-breast surgery and reviews management strategies through a systematic analysis of the literature. Methods: A systematic literature review from 2018 to 2023 identified 24 relevant articles on PG management post-breast surgery. The studies were analyzed to compare the efficacy and complications of conservative versus combined (conservative and surgical) treatment strategies. Results: Results indicate that while conservative management, primarily with corticosteroids, remains preferred, combined strategies, including systemic therapies, vacuum-assisted closure, and surgery, offer significant benefits in select cases. Conclusions: Our findings suggest that a personalized, multifaceted treatment plan is crucial for managing PG effectively, emphasizing the need for early detection, meticulous planning, and comprehensive care to optimize patient outcomes.
C1 [Pop, Ioan Constantin; Ilies, Radu Alexandru; Muntean, Maximilian] Prof Dr I Chiricuta Inst Oncol, Plast Surg Dept, Cluj Napoca 400015, Romania.
   [Baican, Corina] Cty Emergency Hosp, Dermatol Dept, Cluj Napoca 400006, Romania.
   [Strilciuc, Stefan] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania.
   [Strilciuc, Stefan] RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca 400337, Romania.
   [Muntean, Valentin] Humanitas Clin Hosp, Gen Surg Dept, Cluj Napoca 400012, Romania.
C3 Oncology Institute Prof. Dr. Ion Chiricuta; Iuliu Hatieganu University
   of Medicine & Pharmacy
RP Strilciuc, S (通讯作者)，Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania.; Strilciuc, S (通讯作者)，RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca 400337, Romania.
EM drp.ionut@gmail.com; iliesradu.14@gmail.com; cibaican@yahoo.com;
   strilciuc.stefan@umfcluj.ro; valentin.muntean@gmail.com;
   maximilian.muntean@iocn.ro
RI Muntean, Maximilian/AGX-3926-2022; Pop, Ioan-Constantin/NOE-5241-2025;
   Strilciuc, Stefan/AAC-6253-2019
OI Muntean, Maximilian/0000-0003-0709-8779; Pop,
   Ioan-Constantin/0000-0002-7079-1106; Strilciuc,
   Stefan/0000-0001-6112-0223; Muntean, Maximilian/0000-0003-0709-8779
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NR 36
TC 8
Z9 9
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2024
VL 13
IS 13
AR 3800
DI 10.3390/jcm13133800
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YD8D1
UT WOS:001266630800001
PM 38999365
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lucas, JW
   Lester, KM
   Chen, A
   Simhan, J
AF Lucas, Jacob W.
   Lester, Kyle M.
   Chen, Andrew
   Simhan, Jay
TI Scrotal reconstruction and testicular prosthetics
SO TRANSLATIONAL ANDROLOGY AND UROLOGY
LA English
DT Review
DE Fournier's gangrene (FG); hydrocele; prosthesis implantation; scrotum;
   skin grafting; trauma
ID VACUUM-ASSISTED CLOSURE; TESTIS CANCER SURVIVORS; THICKNESS SKIN-GRAFTS;
   FOURNIERS GANGRENE; HIDRADENITIS SUPPURATIVA; PENILE LENGTH; PATIENT
   SATISFACTION; VENTRAL PHALLOPLASTY; GENITAL LYMPHEDEMA; RANDOMIZED-TRIAL
AB Scrotal surgery encompasses a wide-variety of surgical techniques for an even wider variety of indications. In this manuscript, we review our indications, techniques, and pit-falls for various reconstructive scrotal surgeries as-well-as surgical tips for placement of testicular prostheses. Penoscrotal webbing (PSW) is an abnormal, often-problematic distal insertion of scrotal skin onto the ventral penile shaft. There are several effective and straightforward techniques used to revise this condition, which include simple scrotoplasty, single-or double-Z-plasty, or the VY-flap scrotoplasty. Reconstruction is also commonly indicated following scrotal skin loss caused by infection, trauma, lymphedema, hidradenitis, and cancer. Although initial management of these conditions often involves scrotal skin removal, repair of expansive scrotal skin loss can be technically difficult and can be accomplished by using one of several skin flaps or skin grafting. Splitthickness skin grafting of scrotal defects can be accomplished easily, and provides durable results.
C1 [Lucas, Jacob W.; Lester, Kyle M.; Chen, Andrew; Simhan, Jay] Einstein Healthcare Network Fox Chase Canc Ctr, Dept Urol, Philadelphia, PA USA.
RP Simhan, J (通讯作者)，Temple Hlth & Fox Chase Canc Ctr, 1200 Tabor Rd,Moss 3 Sley, Philadelphia, PA 19141 USA.
EM jsimhan@gmail.com
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NR 77
TC 19
Z9 27
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2223-4683
EI 2223-4691
J9 TRANSL ANDROL UROL
JI Transl. Androl. Urol.
PD AUG
PY 2017
VL 6
IS 4
BP 710
EP 721
DI 10.21037/tau.2017.07.06
PG 12
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA FF1OI
UT WOS:000408668400013
PM 28904904
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
AF Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
TI Negative-pressure dressings in the treatment of pressure ulcers
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative pressure dressings; negative pressure therapy; pressure ulcers;
   healing index; skin ulcers
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; STRESS
AB Applying negative pressure to wounds may speed the formation of granulation tissue, decrease the amount of localized edema, increase blood flow, and accelerate healing. In the present study, we treated ten patients with stage IV chronic pressure ulcers using this negative pressure dressing technique. The long (A) and short (B) diameters of each ulcer were measured to determine size, and the vertical distance from the skin to the deepest point of the ulcer was measured to determine depth. Lesions were measured initially and at weekly intervals. The area of each lesion was taken to be 3.14 x A/2 x B/2 (cm(2)). When we compared the area of ulcer before and after the treatment, the area had been reduced in all cases, and the average reduction was 55.1%. The depth of ulcer also decreased in all cases, and the average reduction was 61.2%. Over the period of evaluation, the method was considered markedly effective in reducing the size and depth of ulcers.
C1 Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan.
   Natl Disaster Med Ctr, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Isago, T (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Falanga Vincent, 1992, Journal of Dermatology (Tokyo), V19, P667
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NR 19
TC 17
Z9 27
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD APR
PY 2003
VL 30
IS 4
BP 299
EP 305
DI 10.1111/j.1346-8138.2003.tb00391.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 672RD
UT WOS:000182534500003
PM 12707466
DA 2026-07-24
ER

PT J
AU Lee, KN
   Seo, DM
   Hong, JP
AF Lee, Kangwoo Nathan
   Seo, Dong Man
   Hong, Joon Pio
TI The effect and safety after extended use of continuous negative pressure
   of 75 mmHg over mesh and allodermis graft on open sternal wound from
   oversized heart transplant in a 3-month-old infant
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Heart transplant; Negative pressure therapy; Paediatric sternal wound
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY; WALL
AB Negative pressure therapy (NPT) has been reported to be effective in treating infants with open chest wounds. This report further supports its effectiveness by treating a 3-month-old infant with a 12 x 7 cm sized opening in its chest after an oversized heart transplantation. After applying a mesh and allodermis over the defect, 75-mmHg continuous negative pressure was set and used for an extended period of 104 days. The haemodynamic status was evaluated during this period. The wound was closed with secondary intention and it healed well after NPT. There was no haemodynamic instability during the treatment course. The extended use of a continuous negative pressure of 75 mmHg over the mesh and alloderm graft was a reliable and safe option to close the massive defect in the chest of a 3-month-old infant.
C1 [Lee, Kangwoo Nathan; Seo, Dong Man; Hong, Joon Pio] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast Surg, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Dept Thorac Surg, Asan Med Ctr, Coll Med, 86 Asan Beyoungwongil Poongnapdong Songpagu, Seoul, South Korea.
EM joonphong@amc.seoul.kr
RI ; Hong, Joon/AEV-0712-2022
OI Seo, Dong Man/0000-0002-5831-7954; 
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Kim EK, 2007, ANN PLAS SURG, V58, P536, DOI 10.1097/01.sap.0000245121.32831.47
   Kim H, 2006, AM J SURG, V192, P705, DOI 10.1016/j.amjsurg.2006.09.003
   Malmsjö M, 2009, J THORAC CARDIOV SUR, V138, P712, DOI 10.1016/j.jtcvs.2008.11.068
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Petzina R, 2007, J THORAC CARDIOV SUR, V133, P1154, DOI 10.1016/j.jtcvs.2007.01.011
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   Vicchio M, 2008, ANN THORAC SURG, V86, P1399, DOI 10.1016/j.athoracsur.2008.04.030
   Vicchio M, 2007, J THORAC CARDIOV SUR, V134, P254, DOI 10.1016/j.jtcvs.2007.03.024
   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
NR 15
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2010
VL 7
IS 5
BP 379
EP 384
DI 10.1111/j.1742-481X.2010.00702.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NU
UT WOS:000287514300009
PM 20840183
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Duman, ZM
   Timur, B
   Topel, C
   Aksu, T
AF Duman, Zihni M.
   Timur, Baris
   Topel, Cagdas
   Aksu, Timucin
TI Clinical Use of Tailored Computed Tomography to Prevent Poststernotomy
   Dehiscence
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE sternum; computed tomography; CT scan; wound infection
ID STERNAL WOUND-INFECTION; VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY;
   OSTEOPOROSIS
AB Background Morphological and tissue density analysis of the sternum can be performed in the preoperative computed tomography (CT). The purpose of this study was to analyze morphology and tissue density of sternum in CT and effect for comparison sternal instability. Methods Patients with sternal instability ( n = 61) and sternal stability ( n = 66) were enrolled in this study. All of the patients were studied using same thorax CT procedure. All the measurements were performed by one specific cardiovascular radiologist. The Hounsfield units (HUs) were measured in axial sections of the sternum trabecular bone. Results Sternal instability group mean HU was 75.36 +/- 13.19 and sternal stability group HU was 90.24 +/- 12.16 ( p < 0.000). HU is the statically significant predictor of sternal instability. Conclusion Our study showed a significant correlation between the mean HU value of sternum and sternal instability. We think that it is important to evaluate the existing thorax CT while performing preoperative risk analysis for sternal dehiscence.
C1 [Duman, Zihni M.; Timur, Baris; Topel, Cagdas; Aksu, Timucin] Istasyon Mahallesi Turgut Ozal Bulvar 11, Istanbul, Turkey.
RP Duman, ZM (通讯作者)，Istanbul Mehmet Akif Ersoy Gogus Kalp & Damar Cer, Istasyon Mah Turgut Ozal Blv 11 Kucukcekmece, TR-34303 Istanbul, Turkey.
EM dumanzihnimert@gmail.com
RI Duman, Zihni Mert/HHZ-3351-2022; Timur, Barış/KLD-2135-2024; TOPEL,
   CAGDAS/KCY-4084-2024
OI Duman, Zihni Mert/0000-0002-3628-8080; Timur, Barış/0000-0003-4446-6374;
   
CR Batawil N, 2016, RADIOGRAPHY, V22, pE93, DOI 10.1016/j.radi.2015.11.004
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   Keskin M, 2008, SCAND J PLAST RECONS, V42, P202, DOI 10.1080/02844310802091586
   Knol WG, 2021, SEMIN THORAC CARDIOV, V33, P417, DOI 10.1053/j.semtcvs.2020.09.027
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   Onan B, 2020, TURK GOGUS KALP DAMA, V28, P708, DOI 10.5606/tgkdc.dergisi.2020.19614
   Pai S, 2005, ANN THORAC SURG, V80, P962, DOI 10.1016/j.athoracsur.2005.03.089
   Pan L, 2017, J THORAC DIS, V9, P3031, DOI 10.21037/jtd.2017.08.41
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NR 19
TC 0
Z9 1
U1 1
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD JAN
PY 2022
VL 70
IS 01
BP 72
EP 76
DI 10.1055/s-0041-1736243
EA DEC 2021
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA YW0TU
UT WOS:000736747300004
PM 34972236
DA 2026-07-24
ER

PT J
AU Riccio, M
   Pangrazi, PP
   Campodonico, A
   Bertani, A
AF Riccio, M
   Pangrazi, PP
   Campodonico, A
   Bertani, A
TI Delayed microsurgical reconstruction of the extremities for complex
   soft-tissue injuries
SO MICROSURGERY
LA English
DT Article
ID PERIPHERAL VASCULAR-DISEASE; DIABETIC NEUROPATHIC FOOT; HYPERBARIC
   OXYGEN; LIMB SALVAGE; MANAGEMENT; TRANSPLANTATION; OSTEOMYELITIS;
   FRACTURES; FLEXION; TRAUMA
AB The treatment of severe wounds of the extremities, characterized by large posttraumatic tissue loss, represents a clinical problem difficult to resolve, especially when the lesion is surrounded by large areas of ischemic distrophic tissue which progressively aggravate and extend the initial lesion, with frequent exposure of bone and joint structures making the amputation of the limb an inevitable outcome. The authors present their experience based on combined treatments by medical support methods such as hyperbaric oxygen (HBO) and vacuum-assisted closure therapy (VAC) and microsurgical reconstruction of the limbs, within a precise therapeutic protocol. The use of this protocol in appropriate times and ways allowed us to successfully treat severe posttraumatic sequelae of the limbs, avoiding the delayed healing typical of these pathologies, both on the donor site of the flap and on the repaired area, and avoiding unsuitable microsurgical reconstruction of limbs, allowing satisfactory morpho-functional restoration and a reduction of the hospitalization period. (c) 2005 Wiley-Liss, Inc.
C1 Univ Politecn Marche, Clin Chirurg Plast & Ricostrutt, Azienda Osped, I-60020 Ancona, Italy.
   Univ Ancona, Sch Med, Hand Surg & Microsurg Unit, Dept Plast & Reconstruct Surg,Ancona Teaching Hos, Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Riccio, M (通讯作者)，Univ Politecn Marche, Clin Chirurg Plast & Ricostrutt, Azienda Osped, Via Conca 71,Azienda Osped Osped Riuniti Umberto, I-60020 Ancona, Italy.
EM michriccio@libero.it
RI ; Riccio, Michele/ABD-2515-2020
OI Campodonico, Anea/0000-0003-1234-978X; Riccio,
   Michele/0000-0001-5554-4759
CR ARNEZ ZM, 1991, CLIN PLAST SURG, V18, P449
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NR 38
TC 13
Z9 18
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PY 2005
VL 25
IS 4
BP 272
EP 283
DI 10.1002/micr.20132
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 945LQ
UT WOS:000230504400005
PM 15934116
DA 2026-07-24
ER

PT J
AU Zarnescu, NO
   Dumitrascu, I
   Zarnescu, EC
   Costea, R
AF Zarnescu, Narcis Octavian
   Dumitrascu, Ioana
   Zarnescu, Eugenia Claudia
   Costea, Radu
TI Abdominal Compartment Syndrome in Acute Pancreatitis: A Narrative Review
SO DIAGNOSTICS
LA English
DT Review
DE acute pancreatitis; abdominal compartment syndrome; compartment
   syndrome; intra-abdominal hypertension; surgery
ID LINEA ALBA FASCIOTOMY; ELEVATED INTRAABDOMINAL PRESSURE; CRITICALLY-ILL
   PATIENTS; INTENSIVE-CARE-UNIT; ORGAN FAILURE; DECOMPRESSIVE LAPAROTOMY;
   POLYCOMPARTMENT SYNDROME; FLUID RESUSCITATION; PERFUSION-PRESSURE;
   D-LACTATE
AB Abdominal compartment syndrome (ACS) represents a severe complication of acute pancreatitis (AP), resulting from an acute and sustained increase in abdominal pressure >20 mmHg, in association with new organ dysfunction. The harmful effect of high intra-abdominal pressure on regional and global perfusion results in significant multiple organ failure and is associated with increased morbidity and mortality. There are several deleterious consequences of elevated intra-abdominal pressure on end-organ function, including respiratory, cardiovascular, gastrointestinal, neurologic, and renal effects. It is estimated that about 15% of patients with severe AP develop intra-abdominal hypertension or ACS, with a mortality rate around 50%. The treatment of abdominal compartment syndrome in acute pancreatitis begins with medical intervention and percutaneous drainage, where possible. Abdominal compartment syndrome unresponsive to conservatory treatment requires immediate surgical decompression, along with vacuum-assisted closure therapy techniques, followed by early abdominal fascia closure.
C1 [Zarnescu, Narcis Octavian; Dumitrascu, Ioana; Zarnescu, Eugenia Claudia; Costea, Radu] Carol Davila Univ Med & Pharm, Dept Gen Surg, Bucharest 050474, Romania.
   [Zarnescu, Narcis Octavian; Dumitrascu, Ioana; Zarnescu, Eugenia Claudia; Costea, Radu] Univ Emergency Hosp Bucharest, Dept Surg 2, Bucharest 050098, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Zarnescu, NO; Zarnescu, EC (通讯作者)，Carol Davila Univ Med & Pharm, Dept Gen Surg, Bucharest 050474, Romania.; Zarnescu, NO; Zarnescu, EC (通讯作者)，Univ Emergency Hosp Bucharest, Dept Surg 2, Bucharest 050098, Romania.
EM narcis.zarnescu@umfcd.ro; eugenia.zarnescu@umfcd.ro
RI Zarnescu, Narcis Octavian/J-4196-2015; Zarnescu, Eugenia
   Claudia/AFV-2571-2022; Costea, Radu/AAB-1368-2020
OI Zarnescu, Narcis Octavian/0000-0003-3973-6309; Costea,
   Radu/0000-0003-0509-693X
CR Al-Bahrani AZ, 2008, PANCREAS, V36, P39, DOI 10.1097/mpa.0b013e318149f5bf
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NR 137
TC 19
Z9 23
U1 2
U2 24
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD JAN
PY 2023
VL 13
IS 1
AR 1
DI 10.3390/diagnostics13010001
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7P9GF
UT WOS:000909005300001
PM 36611293
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gale, SS
   Lurie, F
   Treadwell, T
   Vazquez, J
   Carman, T
   Partsch, H
   Alvarez, O
   Langemo, D
   Posthauer, ME
   Cheney, M
   Wilkin, MM
   Bursztynski, M
AF Gale, Steven S.
   Lurie, Fedor
   Treadwell, Terry
   Vazquez, Jose
   Carman, Teresa
   Partsch, Hugo
   Alvarez, Oscar
   Langemo, Diane
   Posthauer, Mary Ellen
   Cheney, Mary
   Wilkin, Matthew M.
   Bursztynski, Michael
TI DOMINATE Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE chronic ulcers; clinical management; negative pressure; debridement
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CHRONIC LEG ULCERS;
   ANTIMICROBIAL RESISTANCE; BIOLOGIC SCAFFOLDS; CONTROLLED-TRIAL;
   DOUBLE-BLIND; HEALTH-CARE; BLOOD-FLOW; THERAPY
AB Chronic wounds are a significant health problem worldwide. Often they are initially managed with various focal treatments until a specialist becomes involved, sometimes weeks or months after treatment has begun. Even at the specialist level, practices and guidelines are inconsistent due to a lack of high-level evidence. A disease management system for chronic wounds that is simple, practical, and adoptable by a variety of wound care practitioners is needed. Such a system would guide wound care providers to address the critical aspects of wound care in a prioritized, systematic sequence, leading to faster healing of simple wounds, and timely advancement to more complex therapies for wounds that require such treatment. This paper describes an empirically developed wound care management system that has been successfully implemented and provides evidence-based rationale for each of its components. Relatively simple and practical, this system organizes an approach to any type of wound, routine or complex.
C1 [Gale, Steven S.; Lurie, Fedor] Jobst Vasc Inst, Toledo, OH USA.
   [Treadwell, Terry] Inst Adv Wound Care, Montgomery, AL USA.
   [Vazquez, Jose] Georgia Regents Univ, Augustus, GA USA.
   [Carman, Teresa] Univ Hosp Case Med Ctr, Cleveland, OH USA.
   [Partsch, Hugo] Med Univ Vienna, Vienna, Austria.
   [Alvarez, Oscar] Calvary Hosp, Ctr Curat & Palliat Wound Care, Bronx, NY USA.
   [Langemo, Diane] Univ N Dakota, Coll Nursing, Grand Forks, ND 58201 USA.
   [Posthauer, Mary Ellen] MEP Healthcare Dietary Serv Inc, Evansville, IN USA.
   [Cheney, Mary; Wilkin, Matthew M.] ProMed Wound Care, Toledo, OH USA.
   [Bursztynski, Michael] Hanger Orthot, Toledo, OH USA.
C3 University System of Georgia; Augusta University; University System of
   Ohio; Case Western Reserve University; Case Western Reserve University
   Hospital; Medical University of Vienna; University of North Dakota Grand
   Forks
RP Gale, SS (通讯作者)，2109 Hughes Dr,Suite 400, Toledo, OH 43606 USA.
EM ssg@bex.net
RI Partsch, Hugo/H-4214-2019; Carman, Teresa/ADN-7358-2022
OI Lurie, Fedor/0000-0003-0644-0560
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NR 78
TC 10
Z9 15
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2014
VL 26
IS 1
BP 1
EP 12
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 297PH
UT WOS:000330266900002
PM 30103297
DA 2026-07-24
ER

PT J
AU Hauer, T
   Grobert, S
   Gaab, J
   Huschitt, N
   Willy, C
AF Hauer, Thorsten
   Grobert, Steffen
   Gaab, Jasmin
   Huschitt, Niels
   Willy, Christian
TI Blast injuries part 2 Principles of medical treatment
SO UNFALLCHIRURG
LA German
DT Article
DE Extremity injuries; Soft tissue injuries; Infection control; Wound
   closure techniques; Amputation
ID MASSIVE TRANSFUSION PROTOCOLS; DAMAGE CONTROL RESUSCITATION; ACUTE
   THERAPEUTIC MEASURES; PRESSURE WOUND THERAPY; OPEN FRACTURES;
   DEBRIDEMENT; PREVENTION; COVERAGE; CLOSURE; TRAUMA
AB Explosions can cause severe injuries, which affect multiple organ systems and leave extensive soft tissue defects. In unstable patients, damage control surgery initially focuses exclusively on controlling bleeding and contamination with the aim of preserving life and limbs. The excision of all necrotic tissue, extensive wound irrigation with antiseptic solutions and a calculated antibiotic prophylaxis, which is subsequently adapted to the microbiological findings, are the basis for sufficient infection control. As the tissue damage caused by the pressure surge can regenerate over time as well as become secondarily necrotic (developing wounds), several revision operations are often necessary to assess the viability of tissue in the sense of serial debridement. In the case of extensive soft tissue injuries temporary vacuum-assisted closure (VAC) techniques can bridge the time to the earliest possible definitive plastic surgical wound closure; however, this must not delay the closure of the defect.
C1 [Hauer, Thorsten; Grobert, Steffen; Huschitt, Niels] Bundeswehrkrankenhaus Berlin, Klin Allgemein & Viszeralchirurg, Scharnhorststr 13, D-10115 Berlin, Germany.
   [Gaab, Jasmin; Willy, Christian] Bundeswehrkrankenhaus Berlin, Klin Orthopadie & Unfallchirurg, Sept & Rekonstrukt Chirurg, Berlin, Germany.
RP Hauer, T (通讯作者)，Bundeswehrkrankenhaus Berlin, Klin Allgemein & Viszeralchirurg, Scharnhorststr 13, D-10115 Berlin, Germany.
EM ThorstenHauer@Bundeswehr.org
OI Grobert, Steffen/0000-0002-6129-1011
CR American College of Surgeons ATLS, 2008, ATLS ADV TRAUM LIF S
   Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
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NR 40
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD MAR
PY 2022
VL 125
IS 3
SI SI
BP 227
EP 242
DI 10.1007/s00113-021-01135-y
EA FEB 2022
PG 16
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA ZI1MG
UT WOS:000754239300001
PM 35147710
DA 2026-07-24
ER

PT S
AU Idelevich, EA
   Kreis, C
   Löffler, B
   Peters, G
AF Idelevich, Evgeny A.
   Kreis, Carolin
   Loeffler, Bettina
   Peters, Georg
BE Bagnoli, F
   Rappuoli, R
   Grandi, G
TI Staphylococcus aureus-Associated Musculoskeletal Infections
SO STAPHYLOCOCCUS AUREUS: MICROBIOLOGY, PATHOLOGY, IMMUNOLOGY, THERAPY AND
   PROPHYLAXIS
SE Current Topics in Microbiology and Immunology
LA English
DT Review; Book Chapter
ID SMALL-COLONY VARIANTS; PYOGENIC VERTEBRAL OSTEOMYELITIS; ACUTE
   HEMATOGENOUS OSTEOMYELITIS; ERYTHROCYTE SEDIMENTATION-RATE;
   BIOABSORBABLE BONE SUBSTITUTE; RANDOMIZED CLINICAL-TRIAL; INTRAVENOUS
   DRUG-ABUSERS; DIABETIC FOOT INFECTIONS; VACUUM-ASSISTED CLOSURE; SEPTIC
   ARTHRITIS
AB Musculoskeletal infections caused by Staphylococcus aureus are among the most difficult-to-treat infections. S. aureus osteomyelitis is associated with a tremendous disease burden through potential for long-term relapses and functional deficits. Although considerable advances have been achieved in diagnosis and treatment of osteomyelitis, the management remains challenging and impact on quality of life is still enormous. S. aureus acute arthritis is relatively seldomin general population, but the incidence is considerably higher in patients with predisposing conditions, particularly those with rheumatoid arthritis. Rapidly destructive course with high mortality and disability rates makes urgent diagnosis and treatment of acute arthritis essential. S. aureus pyomyositis is a common disease in tropical countries, but it is very seldom in temperate regions. Nevertheless, the cases have been increasingly reported also in non-tropical countries, and the physicians should be able to timely recognize this uncommon condition and initiate appropriate treatment. The optimal management of S. aureus-associated musculoskeletal infections requires a strong interdisciplinary collaboration between all involved specialists.
C1 [Idelevich, Evgeny A.; Peters, Georg] Univ Hosp Munster, Inst Med Microbiol, D-48149 Munster, Germany.
   [Kreis, Carolin] Univ Hosp Munster, Dept Trauma Hand & Reconstruct Surg, Munster, Germany.
   [Loeffler, Bettina] Jena Univ Hosp, Inst Med Microbiol, Jena, Germany.
C3 University of Munster; University of Munster; Friedrich Schiller
   University of Jena
RP Peters, G (通讯作者)，Univ Hosp Munster, Inst Med Microbiol, D-48149 Munster, Germany.
EM georg.peters@uni-muenster.de
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NR 174
TC 6
Z9 10
U1 1
U2 8
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0070-217X
EI 2196-9965
BN 978-3-319-72063-0; 978-3-319-72061-6
J9 CURR TOP MICROBIOL
JI Curr.Top.Microbiol.Immunol.
PY 2017
VL 409
BP 229
EP 261
DI 10.1007/82_2016_19
D2 10.1007/978-3-319-72063-0
PG 33
WC Immunology; Infectious Diseases; Microbiology
WE Book Citation Index– Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA BL8GP
UT WOS:000456331000009
PM 27380269
DA 2026-07-24
ER

PT J
AU Olona, C
   Caro, A
   Duque, E
   Moreno, F
   Vadillo, J
   Rueda, JC
   Vicente, V
AF Olona, C.
   Caro, A.
   Duque, E.
   Moreno, F.
   Vadillo, J.
   Rueda, J. C.
   Vicente, V.
TI Comparative study of open abdomen treatment: ABThera™ vs. abdominal
   dressing™
SO HERNIA
LA English
DT Article
DE Negative pressure therapy; Open abdomen; Abdominal closure
ID VACUUM-ASSISTED CLOSURE; COMPARTMENT SYNDROME; MANAGEMENT; SURGERY;
   STRATEGIES; TRAUMA; SYSTEM
AB Negative pressure therapy (NPT) is a widely recognised procedure for the temporary closure of open abdominal wounds. In this study, we compare two NPT products, the V.A.C.A (R) abdominal dressing (AD) system and the new ABThera (TM) (ABT) system, in terms of the primary closure rates achieved, types of closure, and the associated morbidity.
   We employed a retrospective comparative study of open-abdomen patients treated with NPT using either AD or ABT. The indications for treatment were damage control surgery, abdominal compartment syndrome, or severe abdominal sepsis.
   The group of patients treated with ABT showed a higher percentage of primary closures (41 vs. 11 %) and required fewer days of NPT (17 vs. 26 days) than the AD group. Differences were statistically significant. In addition, only 4 % of patients in the ABT group exhibited enteroatmospheric fistulae, compared to 17 % in the AD group.
   Compared to the AD system, ABT can achieve faster primary closure after open abdomen treatment with only minor complications.
C1 [Olona, C.; Caro, A.; Duque, E.; Moreno, F.; Vadillo, J.; Rueda, J. C.; Vicente, V.] Univ Hosp Joan XXIII Tarragona, Digest & Gen Surg Dept, Tarragona 43007, Spain.
RP Olona, C (通讯作者)，Univ Hosp Joan XXIII Tarragona, Digest & Gen Surg Dept, 4th Dr Mallafre Guasch St 3th Floor, Tarragona 43007, Spain.
EM drcarlesolona@gmail.com
OI Caro, Aleidis/0000-0001-6151-3879; Vicente, Vicente/0000-0002-4278-3264
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NR 20
TC 20
Z9 20
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2015
VL 19
IS 2
BP 323
EP 328
DI 10.1007/s10029-014-1253-5
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE3BS
UT WOS:000351699800021
PM 24756917
DA 2026-07-24
ER

PT J
AU Morinaga, K
   Rikimaru, Y
   Kiyokawa, K
AF Morinaga, Keigo
   Rikimaru, Yukiko
   Kiyokawa, Kensuke
TI Treatment of Abdominal Surgical Wound Dehiscence With Bowel Exposure and
   Infection Using Intrawound Continuous Negative Pressure, Irrigation, and
   Application of Artificial Dermis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominal surgical wound dehiscence; bowel exposure; intrawound
   continuous negative pressure and irrigation treatment; artificial dermis
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; MANAGEMENT; COMPLICATIONS;
   THERAPY
AB Abdominal surgical wound dehiscence with bowel exposure and infection carries a risk of intestinal fistula, making it extremely difficult to treat. The objective at this time is to heal such wounds safely and absolutely with using intrawound continuous negative pressure and irrigation treatment and artificial dermis. The subjects were 18 patients with abdominal wall dehiscence wounds with bowel exposure. Complications had already developed in 4 of the 18 cases of intestinal fistula. Subsequently, these 4 cases were treated with conservative treatment alone, whereas the other 14 were treated by split-thickness skin grafts. Intrawound continuous negative-pressure therapy has enabled the concomitant use of an artificial dermis inside the infected wound by maintaining irrigation of the wound. This method not only eliminated the danger of perforation from direct contact of the sponge with the bowel but also promoted the early proliferation of dermis-like tissue on the bowel surface, enabling safe and absolute healing.
C1 [Morinaga, Keigo; Rikimaru, Yukiko; Kiyokawa, Kensuke] Kurume Univ Hosp, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Kiyokawa, K (通讯作者)，Kurume Univ Hosp, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
OI Rikimaru-Nishi, Yukiko/0009-0007-8486-2810
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
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   Vargo D, 2009, AM SURGEON, V75, pS1
NR 20
TC 5
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2019
VL 82
IS 2
BP 213
EP 217
DI 10.1097/SAP.0000000000001739
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HN0RJ
UT WOS:000459895800018
PM 30628933
DA 2026-07-24
ER

PT J
AU Denaro, V
   Longo, UG
   Salvatore, G
   Candela, V
   Maffulli, N
AF Denaro, Vincenzo
   Longo, Umile Giuseppe
   Salvatore, Giuseppe
   Candela, Vincenzo
   Maffulli, Nicola
TI Subcutaneous emphysema of the leg after hardware removal and bone
   allografting for infected non-union of the distal femur
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Gangrene; Fracture; Hardware removal; Femur
ID LONG BONES; IN-VITRO; FRACTURES
AB Background: Infected non-unions of the supracondylar region of the femur are uncommon. Even though hardware removal is a common procedure, it may lead to complications, including neurovascular injury, refracture, worsening pain or recurrence of deformity.
   Case presentation: We report on a male who developed subcutaneous emphysema of the leg after hardware removal and bone allografting for an infected non-union of the distal femur. He was managed by debridement of the surgical wound, antibiotic therapy, multiple fasciotomies, and application of a VAC (vacuum-assisted closure) system.
   Conclusions: Although subcutaneous emphysema of the leg after hardware removal and bone allografting for infected non-union of the distal femur is extremely rare, the potential life treating complications and their potential impact on the functional status of the patient have to be taken into consideration when counseling patients about this procedure. Even when it is not possible to identify a bacterial pathogen responsible for the subcutaneous emphysema of the leg, prompt intervention may save the limb of the patient.
C1 [Denaro, Vincenzo; Longo, Umile Giuseppe; Salvatore, Giuseppe; Candela, Vincenzo] Campus Biomed Univ, Dept Orthopaed & Trauma Surg, Via Alvaro Portillo 200, I-00128 Rome, Italy.
   [Maffulli, Nicola] Mile End Hosp, Barts & London Sch Med & Dent, Ctr Sports & Exercise Med, 275 Bancroft Rd, London E1 4DG, England.
   [Maffulli, Nicola] Univ Salerno, Sch Med, Salerno, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of London; Queen
   Mary University London; Barts Health NHS Trust; Mile End Hospital;
   University of Salerno
RP Longo, UG (通讯作者)，Campus Biomed Univ, Dept Orthopaed & Trauma Surg, Via Alvaro Portillo 200, I-00128 Rome, Italy.
EM g.longo@unicampus.it
RI Denaro, Vincenzo/K-9567-2016; Candela, Vincenzo/IQU-2446-2023; Longo,
   Umile Giuseppe/K-9147-2016; Salvatore, Giuseppe/AAC-5947-2022; Maffulli,
   Nicola/A-1839-2014
OI Candela, Vincenzo/0000-0003-0047-2748; Longo, Umile
   Giuseppe/0000-0003-4063-9821; Salvatore, Giuseppe/0000-0003-1937-3272; 
CR Bose D, 2015, BONE JOINT J, V97B, P814, DOI 10.1302/0301-620X.97B6.33276
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   Kainer MA, 2002, P 40 ANN INF DIS SOC
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   Longo Umile Giuseppe, 2012, Open Orthop J, V6, P564, DOI 10.2174/1874325001206010564
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NR 17
TC 2
Z9 2
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD AUG 15
PY 2017
VL 18
AR 351
DI 10.1186/s12891-017-1706-y
PG 6
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA FE3AN
UT WOS:000408088900002
PM 28810893
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhai, Z
   Yu, L
   Ren, TJ
   Jin, XL
   Yang, XN
   Qi, ZL
AF Zhai, Zhen
   Yu, Lu
   Ren, TianJian
   Jin, Xiaolei
   Yang, Xiaonan
   Qi, Zuoliang
TI Use of Vacuum-Assisted Wound Closure and Tissue Expansion in Revision
   Cranioplasty for a Large-Sized Composite Defect in a Child
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cranioplasty; pediatrics; revision surgery; tissue expansion; vacuum
   assisted closure
ID RECONSTRUCTION; THERAPY; SCALP
AB Cranioplasty is generally defined as the procedure to reconstruct cranial bone defect arising from congenital or acquired process. As a surgical remedy, it can restore the function of original anatomical structure and produce a satisfactory cosmetic outcome. Although with available options for treating pediatric cranioplasty, large format ( ie, >25 cm(2)) cranioplasty of the aborted one with a composite defect is still a challenging procedure for plastic surgeons. The authors herein present a case of child who suffered failed cranioplasty with polyetheretherketone caused by postoperative infection, leading to skin ulcer and exposure of the polyetheretherketone. The treatments of the patient are performed sequentially. After thorough debridement of the wound, vacuum-assisted wound closure and autologous split-thickness skins are successively used to cover the defect following finally adopted strategy of tissue expansion of the scalp with a 3-dimensional-printed epoxide acrylate maleic composite material to repair the large-sized cranial defect.
C1 [Zhai, Zhen; Yu, Lu; Jin, Xiaolei; Yang, Xiaonan; Qi, Zuoliang] Chinese Acad Med Sci, Plast Surg Hosp, Dept 16, Beijing 100144, Peoples R China.
   [Zhai, Zhen; Yu, Lu; Jin, Xiaolei; Yang, Xiaonan; Qi, Zuoliang] Peking Union Med Coll, Beijing 100144, Peoples R China.
   [Ren, TianJian] Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurol Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Plastic Surgery Hospital - CAMS; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Capital
   Medical University
RP Yang, XN; Qi, ZL (通讯作者)，Chinese Acad Med Sci, Plast Surg Hosp, Dept 16, Beijing 100144, Peoples R China.; Yang, XN; Qi, ZL (通讯作者)，Peking Union Med Coll, Beijing 100144, Peoples R China.
EM yxnan@aliyun.com; public_qi@163.com
RI Yang, Xiaonan/AAL-5154-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bonda DJ, 2015, NEUROSURGERY, V77, P814, DOI 10.1227/NEU.0000000000000899
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   Rocque BG, 2013, J NEUROSURG-PEDIATR, V12, P120, DOI 10.3171/2013.4.PEDS12605
   Strub GM, 2013, FACIAL PLAST SURG CL, V21, P137, DOI 10.1016/j.fsc.2012.11.005
   Williams L, 2016, J CRANIO MAXILL SURG, V44, P789, DOI 10.1016/j.jcms.2016.03.010
   Zanotti B, 2016, J CRANIOFAC SURG, V27, P2061, DOI 10.1097/SCS.0000000000003025
NR 18
TC 3
Z9 4
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2019
VL 30
IS 3
BP 838
EP 840
DI 10.1097/SCS.0000000000005181
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HX9JR
UT WOS:000467724100091
PM 30845080
DA 2026-07-24
ER

PT J
AU Singh, B
   Haffejee, AA
   Allopi, L
   Moodley, J
AF Singh, B.
   Haffejee, A. A.
   Allopi, L.
   Moodley, J.
TI Surgery for High-Output Small Bowel Enterocutaneous Fistula: A 30-Year
   Experience
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Small bowel enterocutaneous fistula; Surgery; Intestinal stenting
ID VACUUM-ASSISTED CLOSURE; GASTROINTESTINAL FISTULAS;
   PARENTERAL-NUTRITION; INTESTINAL TUBE; MANAGEMENT; OBSTRUCTION; SYSTEM;
   TRACT
AB The outcome of surgery undertaken to repair high-output small bowel enterocutaneous fistula (SBECF) using the same technique was evaluated. Of a total of 282 patients with a high-output SBECF (daily fistula output >500 ml), 183 patients were managed conservatively; in this group, a spontaneous closure rate of 81.4% (n = 149) and a mortality rate of 18.6% (n = 34) was noted. Ninety-nine patients (35.1%) underwent definitive surgical treatment. In all patients, after resection of the fistula, the entire small bowel was stented. Six patients (6%) died in the postoperative period. No complications developed as a result of intestinal stenting. Including the patients treated successfully for postoperative persistence of fistula, surgical repair was successful in 93 patients (93.9%). No patients returned with refistulization or small bowel obstruction within 6 months of surgery. We believe that routine intraluminal stenting should be an integral component of the surgical technique for the repair of SBECF.
C1 [Singh, B.; Haffejee, A. A.; Allopi, L.; Moodley, J.] Univ KwaZulu Natal, Coll Hlth Sci, Nelson R Mandela Sch Med, Dept Surg, ZA-4013 Durban, South Africa.
C3 University of Kwazulu Natal
RP Singh, B (通讯作者)，Univ KwaZulu Natal, Coll Hlth Sci, Nelson R Mandela Sch Med, Dept Surg, Private Bag 7, ZA-4013 Durban, South Africa.
EM singhb3@ukzn.ac.za
CR AGUIRRE A, 1974, ANN SURG, V180, P393, DOI 10.1097/00000658-197410000-00003
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NR 35
TC 5
Z9 5
U1 0
U2 0
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD JUL-SEP
PY 2009
VL 94
IS 3
BP 262
EP 268
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 548KJ
UT WOS:000273960700015
PM 20187523
DA 2026-07-24
ER

PT J
AU Asuku, ME
   Ibrahim, A
   Ijekeye, FO
AF Asuku, Malachy E.
   Ibrahim, Abdulrasheed
   Ijekeye, Ferdinand O.
TI Post-burn axillary contractures in pediatric patients: A retrospective
   survey of management and outcome
SO BURNS
LA English
DT Article; Proceedings Paper
CT 12th Annual Scientific Conference of the
   Nigerian-Association-of-Plastic-Reconstructive-and-Aesthetic-Surgeons
CY NOV 01-04, 2006
CL Ile Ife, NIGERIA
SP Nigerian Assoc Plast Reconstruct & Aesthet Surg
DE Axillary contracture; Local flaps; Fasciocutaneous flap; Skin grafts;
   Functional outcome
ID VACUUM-ASSISTED CLOSURE; BURN CONTRACTURES; SKIN-GRAFTS; EXPERIENCE
AB Over a 5-year period, 63 children aged 15 years and less had surgical correction of 74 axillary contractures in our center. They were grouped into three severity categories based on the Kurtzman and Stern's classification. Accordingly, 56 were type I, 11 were type II and 7 were type III axillary contractures. While local flaps sufficed in all the type I contractures, skin grafts and fasciocutaneous flaps were required in types II and III. The principal movements at the shoulder joint were assessed at 2 years after, and functional outcome classified into three outcome categories. Excellent result (A) was obtained in all the type I contractures, 82% of the type II contractures and 28% of the type III contractures. Good result (B) was obtained in 18% of the type 11 and 57% of the type III contractures and poor result (C) was obtained in 14% of the type III contractures. (C) 2008 Elsevier Ltd and ISBI. All rights reserved.
C1 [Asuku, Malachy E.; Ibrahim, Abdulrasheed; Ijekeye, Ferdinand O.] Ahmadu Bello Univ, Dept Surg, Div Plast & Reconstruct Surg, Teaching Hosp, Zaria 810001, Kaduna State, Nigeria.
C3 Ahmadu Bello University
RP Asuku, ME (通讯作者)，Ahmadu Bello Univ, Dept Surg, Div Plast & Reconstruct Surg, Teaching Hosp, PMB 1026, Zaria 810001, Kaduna State, Nigeria.
EM measuku@yahoo.ca
RI /ABC-9208-2020
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NR 16
TC 24
Z9 26
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD DEC
PY 2008
VL 34
IS 8
BP 1190
EP 1195
DI 10.1016/j.burns.2008.04.006
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 380IP
UT WOS:000261459700020
PM 18692966
DA 2026-07-24
ER

PT J
AU O'Loughlin, A
   McIntosh, C
   Dinneen, SF
   O'Brien, T
AF O'Loughlin, Aonghus
   McIntosh, Caroline
   Dinneen, Sean F.
   O'Brien, Timothy
TI Basic Concepts to Novel Therapies: A Review of the Diabetic Foot
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE diabetes foot; ulcer; neuropathy; ischemia; amputation
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED CLOSURE; PRESSURE WOUND
   THERAPY; QUALITY-OF-LIFE; PERIPHERAL NEUROPATHY; SCREENING TECHNIQUES;
   GROWTH-FACTOR; RISK-FACTORS; ULCERS; ULCERATION
AB Diabetes mellitus is a global epidemic. Peripheral neuropathy and peripheral vascular disease are complications of diabetes mellitus and the primary causative factors for foot ulceration. Foot ulceration is the leading cause of hospitalization in people with diabetes mellitus. The burden of foot ulceration on health care systems and individual patients is immense. Despite conventional treatment, there persists a high incidence of amputation. A multidisciplinary approach is required to prevent ulcers. This review describes the etiology and risk factors for diabetic foot ulceration and a system for evaluating the diabetic foot. The assessment of neuropathy and the grading of foot ulcers are critically examined. This is important to allow for standardization in clinical trials. The management of diabetic foot syndrome is reviewed. The treatments to ensure vascular supply to the lower limb and control of infection as well as novel therapies, which are becoming available to treat nonhealing, "no-option" diabetic ulcers, are discussed.
C1 [O'Brien, Timothy] Natl Univ Ireland, Regenerat Med Inst, Natl Ctr Biomed Engn Sci, Galway, Ireland.
   [Dinneen, Sean F.; O'Brien, Timothy] Galway Univ Hosp, Dept Endocrinol, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway
RP O'Brien, T (通讯作者)，Natl Univ Ireland, Regenerat Med Inst, Natl Ctr Biomed Engn Sci, Galway, Ireland.
EM timothy.obrien@nuigalway.ie
RI ; O'Brien, Timothy/N-7112-2014
OI McIntosh, Caroline/0000-0003-1801-9554; Dinneen,
   Sean/0000-0002-6636-0493; O'Brien, Timothy/0000-0001-9028-5481
FU Molecular Medicine Ireland
FX The author(s) disclosed receipt of the following financial support for
   the research and/or authorship of this article: Molecular Medicine
   Ireland for funding Clinical Research Fellowship for Aonghus O'Loughlin
   at the National University of Ireland, Galway, Ireland.
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NR 118
TC 62
Z9 74
U1 2
U2 39
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2010
VL 9
IS 2
BP 90
EP 102
DI 10.1177/1534734610371600
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 851VH
UT WOS:000297298900006
PM 20483808
DA 2026-07-24
ER

PT J
AU Werner, J
   Sauer, P
AF Werner, Jens
   Sauer, Peter
TI Leakage of Intestinal Anastomoses: Endoscopic and Laparoscopic Treatment
   Options
SO VISZERALMEDIZIN
LA German
DT Review
DE Anastomotic leakage; Peritonitis; Mediastinitis; Intestinal anastomosis;
   Laparoscopy; Endoscopy; Treatment options
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE COMPLICATIONS; ESOPHAGEAL
   LEAKAGE; PLASTIC STENTS; BLINDED TRIAL; THERAPY; CANCER; SURGERY;
   MANAGEMENT; PERFORATIONS
AB Background: Anastomotic leakages are severe septic complications after visceral surgical procedures. In addition to surgical treatment, endoscopic techniques are increasingly being used. Method: Literature review. Results: The treatment options of anastomotic leakages depend on clinical symptoms, type of anastomosis, size and location of the defect, local tissue perfusion, and the time point of the diagnosis after surgery. In the case of necrosis, surgical revision and resection needs to be performed to avoid sepsis. All surgical procedures can be performed laparoscopically. In the case of good tissue perfusion, both local repair by surgical sutures and endoscopic techniques are reliable treatment options. While stenting is a promising option after the failure of esophageal anastomosis, vacuum-assisted rectal drainage seems to be a more promising technique for leakages after colorectal surgery. Conclusion: Data of small case series on different treatment options of anastomotic failure demonstrate that laparoscopic and endoscopic management can be performed under certain preconditions. However, prospective randomized trials are needed to confirm this.
C1 [Werner, Jens] Heidelberg Univ, Klin Allgemein Viszeral & Transplantat Chirurg, D-69120 Heidelberg, Germany.
   [Sauer, Peter] Heidelberg Univ, Interdisziplinares Endoskopiezentrum, D-69120 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Werner, J (通讯作者)，Heidelberg Univ, Klin Allgemein Viszeral & Transplantat Chirurg, Neuenheimer Feld 110, D-69120 Heidelberg, Germany.
EM jens.werner@med.uni-heidelberg.de
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   Strobel O, 2011, CHIRURG, V82, P242, DOI 10.1007/s00104-010-2015-2
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedemeyer J, 2012, VISZERALMEDIZIN, V28, P376, DOI 10.1159/000345807
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NR 57
TC 4
Z9 4
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-6664
EI 1662-6672
J9 VISZERALMEDIZIN
JI Viszeralmedizin
PY 2013
VL 29
IS 1
BP 7
EP 13
DI 10.1159/000348266
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 137ZZ
UT WOS:000318479200002
DA 2026-07-24
ER

PT J
AU Jacobs, B
   Ghersi, MM
AF Jacobs, Baruch
   Ghersi, Marcelo M.
TI Intercostal artery-based rectus abdominis transposition flap for sternal
   wound reconstruction
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal reconstruction; rectus abdominis; intercostal perforator flap;
   poststemotomy mediastinitis
ID INFECTED MEDIAN STERNOTOMY; VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS;
   MANAGEMENT
AB The rectus abdominis transposition (RAT) flap is a well-accepted alternative to pectoralis muscle flaps for sternal reconstruction after debridement in poststernotomy mediastinitis. Use of this flap based on an intercostal artery pedicle, after division of the ipsilateral internal mammary artery (IMA), is a less-recognized option for reconstruction, given its less substantial vascular supply. The authors present 15 cases where intercostal artery-based RAT flaps were used for sternal reconstruction over a span of 15 years. They describe patient demographic data, management approaches, surgical techniques, and clinical outcomes. Perioperative flap survival and wound healing was optimal in all cases. One morbidity and 1 mortaliry were encountered in patients with multiple chronic medical problems. Follow-up demonstrated optimal surgical results and satisfied patients. Our observations suggest that the intercostal artery-based RAT flap is a safe treatment option for sternal reconstruction when pectoralis muscle flaps have failed or do not adequately provide coverage of sternal defects after debridement of the poststernotomy wound.
C1 [Jacobs, Baruch; Ghersi, Marcelo M.] Mt Sinai Med Ctr, Dept Plast Surg, Miami Beach, FL 33140 USA.
C3 Mount Sinai Medical Center
RP Ghersi, MM (通讯作者)，Mt Sinai Med Ctr, Dept Surg, 4300 Alton Rd,Suite 2240, Miami Beach, FL 33140 USA.
EM mmghersi@yahoo.com
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NR 31
TC 10
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2008
VL 60
IS 4
BP 410
EP 415
DI 10.1097/SAP.0b013e318070c6fb
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 281ML
UT WOS:000254501600016
PM 18362570
DA 2026-07-24
ER

PT J
AU Bezjian, M
   Wellehan, JFX
   Walsh, MT
   Anderson, E
   Jacobson, E
AF Bezjian, Marisa
   Wellehan, James F. X., Jr.
   Walsh, Michael T.
   Anderson, Eric
   Jacobson, Elliott
TI MANAGEMENT OF WOUNDS IN A LOGGERHEAD SEA TURTLE (CARETTA CARETTA)
   CAUSED BY TRAUMATIC BYCATCH INJURY FROM THE SPINES OF A SPOTTED EAGLE
   RAY (AETOBATUS NARINARI)
SO JOURNAL OF ZOO AND WILDLIFE MEDICINE
LA English
DT Article
DE Aetobatus narinari; bycatch; Caretta caretta; loggerhead turtle;
   stingray spine; trawl net
ID RISK
AB A subadult female loggerhead sea turtle (Caretta caretta) was caught in a trawl net off the west coast of Florida with a spotted eagle ray (Aetobatus narinari) spine lodged in the left stifle. Surgical removal of the spine was performed and antibiotic treatment was initiated. Four weeks later, endoscopy revealed a second spine entering an intestinal lumen. The fistulous tract of the left prefemoral fossa was surgically excised and the intestinal perforation was repaired. Dehiscence occurred and a vacuum-assisted closure (VAC) system was used on the wound for approximately 18 days to help reduce infection and increase the rate of healing. The left stifle wound was treated to heal by second intention. The turtle remained in rehabilitation for 19 mo before being released off the west coast of Florida. This case describes stingray envenomation injuries as a complex and potentially life-threatening bycatch effect to sea turtles caught in trawl nets.
C1 [Bezjian, Marisa; Wellehan, James F. X., Jr.; Jacobson, Elliott] Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
   [Walsh, Michael T.] Univ Florida, Coll Vet Med, Dept Large Anim Clin Sci, Gainesville, FL 32610 USA.
   [Anderson, Eric] Mote Marine Lab & Aquarium, Sarasota, FL 34236 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Mote Marine
   Laboratory & Aquarium
RP Bezjian, M (通讯作者)，Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, 2015 SW 16th Ave, Gainesville, FL 32610 USA.
EM marisa.bezjian@gmail.com
RI Wellehan, Jim/B-2021-2008
OI Wellehan, Jim/0000-0001-5692-6134
CR Bolten AB, 2011, FRONT ECOL ENVIRON, V9, P295, DOI 10.1890/090126
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NR 14
TC 4
Z9 6
U1 0
U2 29
PU AMER ASSOC ZOO VETERINARIANS
PI YULEE
PA 581705 WHITE OAK ROAD, YULEE, FL 32097 USA
SN 1042-7260
EI 1937-2825
J9 J ZOO WILDLIFE MED
JI J. Zoo Wildl. Med.
PD JUN
PY 2014
VL 45
IS 2
BP 428
EP 432
DI 10.1638/2013-0178R.1
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AM2AF
UT WOS:000339649800035
PM 25000714
DA 2026-07-24
ER

PT J
AU Zahiri, HR
   Lumpkins, K
   Kelishadi, S
   Stromberg, JA
   Silverman, RP
   Slezak, S
   Goldberg, NH
   Holton, L
   Singh, DP
AF Zahiri, Hamid R.
   Lumpkins, Kimberly
   Kelishadi, Shahrooz
   Stromberg, Jeffrey A.
   Silverman, Ronald P.
   Slezak, Sheri
   Goldberg, Nelson H.
   Holton, Luther
   Singh, Devinder P.
TI Pectoralis Major Turnover Versus Advancement Technique for Sternal Wound
   Reconstruction
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sternal reconstruction; tissue flaps; pectoralis major turnover;
   pectoralis major advancement
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS; POSTSTERNOTOMY
   MEDIASTINITIS; GREATER OMENTUM; MUSCLE FLAP; STERNOTOMY WOUNDS;
   CARDIAC-SURGERY; TRANSPOSITION; PRESERVATION; INFECTIONS
AB Background: We compared the efficacy of pectoralis turnover versus advancement technique for sternal wound reconstruction.
   Methods: A retrospective chart review was performed, December 1989 to December 2010, to compare postoperative complication rates between pectoralis major turnover versus pectoralis major advancement reconstruction techniques. Complications included hematomas, wound infections, tissue necrosis, dehiscence, and need for reoperation. Pearson chi(2) and logistic regression were used and significance was P < 0.05.
   Results: Sixty-seven patients received 91 tissue flaps. Eleven patients (16%) required reoperation due to complications, including recurrent wound infection, tissue necrosis, wound dehiscence, mediastinitis, and hematoma formation. Four patients (6%) were treated conservatively for minor complications. Overall, complication rates were significantly higher after pectoralis major advancement reconstruction (32.5% vs. 3.7%, P = 0.004).
   Conclusions: When feasible, pectoralis major turnover flap offers a superior reconstructive technique for complex sternal wounds, with diminished complications compared with the pectoralis advancement flap.
C1 [Zahiri, Hamid R.; Lumpkins, Kimberly; Kelishadi, Shahrooz] Univ Maryland, Sch Med, Dept Surg, Div Gen Surg, Baltimore, MD 21201 USA.
   [Stromberg, Jeffrey A.] Cleveland Clin, Sch Med, Dept Surg, Div Gen Surg, Cleveland, OH 44106 USA.
   [Silverman, Ronald P.; Slezak, Sheri; Goldberg, Nelson H.; Holton, Luther; Singh, Devinder P.] Univ Maryland, Sch Med, Dept Surg, Div Plast Surg, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   Cleveland Clinic Foundation; University System of Maryland; University
   of Maryland Baltimore
RP Singh, DP (通讯作者)，Univ Maryland Med, Dept Gen Surg, 22 S Greene St,Room S8D18, Baltimore, MD 21201 USA.
EM DSingh@smail.umaryland.edu
RI ; Slezak, Sheri/AAC-9086-2019; Silverman, Ronald/A-5155-2018; Singh,
   Devinder/AAN-4716-2021
OI Lumpkins, Kimberly/0000-0002-5236-9411; 
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   Stump A, 2010, ANN PLAS SURG, V65, P206, DOI 10.1097/SAP.0b013e3181c9c31a
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NR 23
TC 11
Z9 13
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2013
VL 70
IS 2
BP 211
EP 215
DI 10.1097/SAP.0b013e3182367dc5
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 076NW
UT WOS:000313964300019
PM 22791058
DA 2026-07-24
ER

PT J
AU Deng, B
   Tan, QY
   Wang, RW
   He, Y
   Jiang, YG
   Zhou, JH
   Liang, YG
AF Deng, Bo
   Tan, Qun-You
   Wang, Ru-Wen
   He, Yong
   Jiang, Yao-Guang
   Zhou, Jing-Hai
   Liang, Yong-Gang
TI Surgical strategy for tubercular abscess in the chest wall: experience
   of 120 cases
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Tubercular abscess; Chest wall; Relapse
ID VACUUM-ASSISTED CLOSURE; COLD ABSCESS; OSTEOMYELITIS; MANAGEMENT;
   RESECTION
AB We aim to optimize surgical strategy to decrease relapse of tubercular abscess in the chest wall (TACW).
   The records of 120 patients who underwent surgical treatment for TACW from May 2005 to March 2011 were retrospectively reviewed. We conducted the following surgical treatment as '6C + A' by abbreviating the first alphabet of each step: (i) careful exploration of the abscess; (ii) complete resection; (iii) cavity washing using sodium bicarbonate solution; (iv) coverage using muscle flap; (v) continuous suction and drainage; (vi) compression dressing and (vii) anti-tuberculosis medication.
   One hundred and thirteen cases were discharged for rehabilitation with the first stage wound healing (113/120). Four cases postoperatively suffered from subcutaneous fistula which was healed after dressing changes for 1-2 months. Three patients with an abscess relapse underwent the second operation 2 months after the first operation. Follow-ups ranged from 2 months to 6 years and demonstrated no recurrence.
   We deem the surgical procedures '6C + A' effective to obviate relapse of TACW.
C1 [Deng, Bo; Tan, Qun-You; Wang, Ru-Wen; He, Yong; Jiang, Yao-Guang; Zhou, Jing-Hai; Liang, Yong-Gang] Third Mil Med Univ, Dept Thorac Surg, Inst Surg Res, Daping Hosp, Chongqing 400042, Peoples R China.
C3 Army Medical University
RP Tan, QY (通讯作者)，Third Mil Med Univ, Dept Thorac Surg, Inst Surg Res, Daping Hosp, Changjiang Branch St 10, Chongqing 400042, Peoples R China.
EM superdb@163.com
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   Chang Jung Hyun, 1992, Yonsei Medical Journal, V33, P374
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NR 20
TC 8
Z9 14
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUN
PY 2012
VL 41
IS 6
BP 1349
EP 1352
DI 10.1093/ejcts/ezr209
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 944JA
UT WOS:000304194800031
PM 22241003
OA Bronze
DA 2026-07-24
ER

PT J
AU Hierner, R
   Flour, M
   Notebaert, M
   Tombeur, M
   Kiekens, C
   Degreef, H
   Veckman, L
   Vandermersch, E
   Joosten, E
AF Hierner, Robert
   Flour, Mieke
   Notebaert, Mia
   Tombeur, Michel
   Kiekens, Charlotte
   Degreef, Hugo
   Veckman, Luc
   Vandermersch, Eugene
   Joosten, Etienne
TI Update on plastic surgical management of pressure sores
SO CHIRURGISCHE GASTROENTEROLOGIE
LA German
DT Article
DE pressure sore; flaps
ID VACUUM-ASSISTED CLOSURE; DECUBITUS ULCERS; MYOCUTANEOUS FLAPS; WOUND
   CONTROL; COVERAGE; SURGERY
AB Pressure sores are a serious medical and surgical problem, despite growing knowledge on pathophysiology, diagnosis, prevention and treatment. Pressure ulcer occur in several groups of patients, including elderly patients, patients with central nervous system disease and paralysis, chronically ill patients, debilitated patients, patients with long operation ( in hypothermia) and bedridden patients. Efficient management of pressure sores is based on a multidisciplinary team approach, a 'common language' for diagnosis and documentation, and an integrated treatment concept. Prevention remains the cornerstone of management of pressure sores. Treatment of pressure sores includes systemic and local factors. The conservative treatment is the basis of local wound care. Operative treatment can be understood as adjunct to a no more efficient conservative treatment. Using plastic surgical techniques and principles, even large defects can be successfully reconstructed. Simple wound closure nowadays is not sufficient, the defect must stay closed after resuming normal life activities. This requirement especially applies for the young patient age group. The postoperative care is as important as the operation itself to guarantee complete wound healing and prevent recurrence.
C1 Katholieke Univ Leuven, Univ Klinikum Gasthuisberg, Univ Ziekenhuis Gasthuisberg, Zentrum Mikrochirurg Handchirurg & Verbrennung, B-3000 Louvain, Belgium.
   Katholieke Univ Leuven, Univ Klinikum Gasthuisberg, Multidisziplinares Wundteam, B-3000 Louvain, Belgium.
   Natl Multiple Sklerose Zentrum Melsbroeck, Melsbroeck, Belgium.
C3 KU Leuven; University Hospital Leuven; KU Leuven
RP Hierner, R (通讯作者)，Katholieke Univ Leuven, Univ Klinikum Gasthuisberg, Univ Ziekenhuis Gasthuisberg, Zentrum Mikrochirurg Handchirurg & Verbrennung, Herestr 49, B-3000 Louvain, Belgium.
EM robert.hierner@uz.kuleuven.ac.be
RI Kiekens, Carlotte/V-7545-2018
OI Kiekens, Carlotte/0000-0001-8500-7751
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NR 32
TC 1
Z9 1
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0177-9990
J9 CHIR GASTROENTEROL
JI Chir. Gastroenterol.
PY 2006
VL 22
IS 3
BP 155
EP 168
DI 10.1159/000094584
PG 14
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 125SV
UT WOS:000243463700007
DA 2026-07-24
ER

PT J
AU Lv, ZM
   Yu, LL
   Fu, L
   Wang, QS
   Jia, R
   Ding, WY
   Shen, Y
AF Lv, Zhenmu
   Yu, Lili
   Fu, Lei
   Wang, Qiusheng
   Jia, Rui
   Ding, Wenyuan
   Shen, Yong
TI Revision surgery with dermal regeneration template and vacuum sealing
   drainage for reconstruction of complex wounds following necrosis of
   reattached avulsed skins in a degloving injury A case report
SO MEDICINE
LA English
DT Article
DE bone/tendon exposure; degloving injury; dermal regeneration template;
   pelnac; skin defect
ID NEGATIVE-PRESSURE THERAPY; ARTIFICIAL DERMIS; ASSISTED CLOSURE; TISSUE
   DEFECTS; INTEGRA
AB Rationale: Degloving injury of the upper limb often extends to underlying tendons and bone, which is at high risk of treatment failure if only simple reattachment of defatted avulsed skins was performed. Pelnac dermal regeneration template could be used as a treatment choice for necrosis of the reattached avulsed skins in a degloving injury.
   Patient concerns: A 48-year-old woman with a degloving injury of the right forearm, wrist, and hand received initial treatment by reattachment of the defatted avulsed skins over the wound bed. However, 17 days postoperatively, the reattached skins developed complete necrosis, leaving large size of tissue defects and tendon/bone exposure.
   Diagnosis: Failure to reconstruct the skin and soft-tissue envelop by reattachment of the defatted avulsed skins in a severe degloving injury of the upper limb.
   Interventions: We decided to use a 2-stage procedure of Pelnac dermal regeneration template and secondary skin graft to solve this issue, in consideration of these conditions and the patient' demanding of limb function and aesthetic appearance.
   Outcomes: At the final follow-up, this patient obtained an excellent result, in term of scar quality, aesthetic appearance, and the ability to perform the daily activities.
   Lessons: We believe this could become an interesting option in patients who needed revision procedure for management of complex wounds with tendon/bone exposure following the necrosis of reattached skins in degloving injuries.
C1 [Lv, Zhenmu; Wang, Qiusheng; Jia, Rui] 252 Hosp Peoples Liberat Army China, Dept Hand & Foot Surg, Shijiazhuang, Hebei, Peoples R China.
   [Lv, Zhenmu; Ding, Wenyuan; Shen, Yong] Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
   [Yu, Lili] Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Fu, Lei; Ding, Wenyuan; Shen, Yong] Key Lab Biomech Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Shen, Y (通讯作者)，Hebei Med Univ, Hosp 3, Dept Spine Surg, 139 Zqiang Rd, Shijiazhuang 050051, Hebei, Peoples R China.
EM drshenyongspine@126.com
OI Ding, Wenyuan/0000-0002-7257-4316
CR Bui DT, 2007, PLAST RECONSTR SURG, V119, P2092, DOI 10.1097/01.prs.0000260598.24376.e1
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NR 20
TC 5
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2019
VL 98
IS 23
AR e15864
DI 10.1097/MD.0000000000015864
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IQ4LD
UT WOS:000480721300024
PM 31169690
OA Green Published, gold
DA 2026-07-24
ER

PT J
AU Chen, X
   Zhou, X
   Xia, X
   Chen, Y
   Mao, TC
   Shi, XH
   Zhang, YM
   Fan, DL
AF Chen, Xin
   Zhou, Xin
   Xia, Xin
   Chen, Yao
   Mao, Tongchun
   Shi, Xiaohua
   Zhang, Yiming
   Fan, Dongli
TI Retrospective analysis of related factors affecting skin wound healing
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Wound; surgical treatment; related factors; retrospective analysis
ID CUTANEOUS SCARRING PATHOPHYSIOLOGY; MOLECULAR-MECHANISMS; DERMAL
   FIBROBLASTS; REGENERATION; STRATEGIES; MANAGEMENT; CELLS
AB Objective: The aim of this study was to investigate the related factors in wound healing and to provide clinical evidence for the prevention and treatment of skin wounds, especially refractory wounds. Methods: Five hundred sixty-seven wound cases that were treated at the Department of Plastic and Cosmetic Surgery of Xing iao Hospital in Chongqing, China, from January 2003 to December 2016, were retrospectively reviewed, and the related factors were analyzed using Logistic regression. Results: Single factor analysis of the related factors showed that 7 related factors, namely, age, wound area, wound type, cause of wound formation, surgical treatment, the time from wound formation to surgical treatment and the use of vacuum sealing drainage (VSD), were the influencing factors. Logistic regression analysis showed that there were no significant differences in age, wound type, cause of wound formation or surgical treatment (P > 0.05); however, the time from wound formation to surgical treatment and the use of VSD were the most influential factors affecting wound healing (P < 0.05). Conclusion: The efficacy of wound healing is affected by many factors. According to the type of wound, different treatment plans should be established, the infection should be prevented, and attention should be paid to the treatment time, such that wounds are treated as soon as possible. For the conditioned wound, the technique of VSD can be applied to shorten the healing time, promote wound healing and improve the healing rate of the wound.
C1 [Chen, Xin; Zhou, Xin; Xia, Xin; Chen, Yao; Mao, Tongchun; Shi, Xiaohua; Zhang, Yiming; Fan, Dongli] Third Mil Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Xinqiao Rd, Chongqing 400037, Peoples R China.
C3 Army Medical University
RP Fan, DL (通讯作者)，Third Mil Med Univ, Xinqiao Hosp, Dept Plast & Cosmet Surg, Xinqiao Rd, Chongqing 400037, Peoples R China.
EM fdltmmu@sina.com
RI Zhang, Yiming/IUQ-8681-2023
OI Zhou, Xin/0000-0002-9324-4308
FU National Natural Science Foundation of China [81471876]
FX This research was supported by the National Natural Science Foundation
   of China (No. 81471876).
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NR 21
TC 3
Z9 3
U1 1
U2 12
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 8
BP 8615
EP 8621
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GS3QB
UT WOS:000443533700130
DA 2026-07-24
ER

PT J
AU Zhang, YH
   Zhou, H
   Wu, XF
   Xia, BN
   Wang, FD
   Zhu, J
AF Zhang, Yinhua
   Zhou, Hui
   Wu, Xifang
   Xia, Beinan
   Wang, Fudong
   Zhu, Jun
TI Management of Multiple Skeletal Tuberculosis Wounds Complicated With
   Multiple Deep Sinus Tracts A Case Report
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Nursing; Sinus tract; Skeletal tuberculosis; Vacuum-shielded drainage
   (VSD)
ID VACUUM SEALING DRAINAGE; INFECTION
AB BACKGROUND: Tuberculosis (TB) is a leading infectious disease worldwide. It rarely occurs in the scapula and toe joints and is easily misdiagnosed. Without prompt treatment, the associated lesions can spread to surrounding soft tissues such as joint capsules, muscles, tendons, and fascia. In severe cases, the bones and articular surfaces can become significantly damaged; it is not uncommon for deep skeletal TB wounds with sinus tracts to form, which are very difficult to treat. We report our successful wound care management approach for one patient with multiple skeletal TB complicated with multiple deep sinus tracts. CASE: The patient was treated with anti-TB medications, and wound and bone debridement (sharps, surgical) combined with vacuum-shielded drainage (VSD) (Kula, CG Bio Co Ltd, Gyeonggi-do, South Korea) to fill the sinus tract. We removed the caseous (cheese-like) necrotic tissue, purulent drainage, and necrotic tissue at the base of the wound to ensure optimal wound care. Throughout the course of treatment, we selected different types of dressings to maintain moist wound healing and absorb excessive drainage. After 144 days of treatment, the wound and deep sinus tracts completely healed. CONCLUSIONS: Wounds related to skeletal TB with multiple sinus tracts are difficult to manage and heal. We found our wound protocol that included timely debridement and use of VSD was effective for the management of these complex wounds. Specifically, our approach filled the dead space in the sinus tract, removed excessive drainage, promoted the growth of granulation tissue, and overall promoted tissue healing.
C1 [Zhang, Yinhua; Zhou, Hui] Jiangnan Univ, Affiliated Hosp, Nursing Thyroid & Breast Surg Dept, Wuxi, Jiangsu, Peoples R China.
   [Wu, Xifang; Xia, Beinan] Jiangnan Univ, Affiliated Hosp, Clin Nutr Dept, Wuxi, Jiangsu, Peoples R China.
   [Wang, Fudong; Zhu, Jun] Jiangnan Univ, Affiliated Hosp, Dept Thorac Surg Dept, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University
RP Zhu, J (通讯作者)，Jiangnan Univ, Affiliated Hosp, Thorac Surg Dept, 1000 Hefeng Rd, Wuxi 214062, Jiangsu, Peoples R China.
EM zhjsurgeon@126.com
RI zhu, jun/IAQ-0165-2023
OI zhu, jun/0000-0002-8630-7091
FU Natural Science Foundation of Jiangsu Province [BK20191141]
FX This research was funded by the Natural Science Foundation of Jiangsu
   Province (Grant BK20191141).
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   Xu Tian-tian, 2010, Zhongguo Gu Shang, V23, P641
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   Zhang M, 2020, INT J BIOL MACROMOL, V162, P1414, DOI 10.1016/j.ijbiomac.2020.07.311
NR 15
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2021
VL 48
IS 6
BP 568
EP 572
DI 10.1097/WON.0000000000000828
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA WX4AB
UT WOS:000718539500014
PM 34781314
DA 2026-07-24
ER

PT J
AU Cheng, J
   Zhang, Q
   Feng, SM
   Wu, XD
   Huo, WL
   Ma, Y
   Cai, JP
   Liu, MM
AF Cheng, Jian
   Zhang, Qi
   Feng, Shiming
   Wu, Xiaodong
   Huo, Weiling
   Ma, Yong
   Cai, Jianping
   Liu, Mingming
TI Clover-Style Fasciocutaneous Perforator Flap for Reconstruction of
   Massive Sacral Pressure Sores
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE sacral pressure sores; fasciocutaneous flap; perforator flap;
   reconstruction
ID SUPERIOR GLUTEAL ARTERY; ANGIOGRAPHY; PRINCIPLES; ANATOMY
AB Background
   As a common complication of the long-term bedridden patients, pressure sore is a great challenge for surgeons. The purpose of this study was to explore the surgical method of using a clover-style fasciocutaneous perforator flap raised on the buttocks for the treatment of massive sacral pressure sores and report the clinical outcomes. Methods
   The study included 15 patients from January 2015 to June 2017 with an average age of 52.87 years (range, 32-73 years). The size of the sacral pressure sores ranged from 10 cm x 13 cm to 18 cm x 20 cm. The defects were reconstructed using a fasciocutaneous perforator flap raised on the buttocks after debridement and vacuum sealing drainage treatment for 1 to 2 weeks. All the donor areas were sutured directly. Results
   All flaps survived completely; 13 patients achieved healing by primary intention, and the other 2 patients achieved healing by secondary intention. At the mean follow-up period of 20.8 months (range, 12-46 months), the appearance of the flap, including its texture and color, in all patients was satisfactory. No patients had deep infection, necrosis, or shrinkage of the flap during the follow-up period. One patient had a recurrent bedsore during the 2-year follow-up. Conclusions
   The clover-style fasciocutaneous perforator flap is ideal for the reconstruction of massive sacral pressure sores because it is a relatively simple procedure and results in good appearance and function, few complications, and a low recurrence rate.
C1 [Cheng, Jian; Feng, Shiming; Wu, Xiaodong; Huo, Weiling] Xuzhou Cent Hosp, Dept Orthoped, Xuzhou, Jiangsu, Peoples R China.
   [Cheng, Jian; Zhang, Qi; Ma, Yong; Cai, Jianping] Nanjing Univ Chinese Med, Grad Sch, Nanjing, Peoples R China.
   [Zhang, Qi] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Oncol, Xuzhou, Jiangsu, Peoples R China.
   [Liu, Mingming] Second Peoples Hosp Lianyungang, Dept Orthoped, 161 Xingfu South Rd, Lianyungang, Jiangsu, Peoples R China.
C3 Southeast University - China; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine
RP Liu, MM (通讯作者)，Second Peoples Hosp Lianyungang, Dept Orthoped, 161 Xingfu South Rd, Lianyungang, Jiangsu, Peoples R China.
EM drchengjian@126.com; zhangqixueye@163.com; lanbing3399@sina.com;
   875105325@qq.com; 583118401@qq.com; 407456262@qq.com;
   caijp_0410@163.com; drorthop@126.com
RI ; Cai, Jianping/OHR-4475-2025
OI Cheng, Jian/0000-0001-8100-4182; 
CR Ahmadzadeh R, 2007, PLAST RECONSTR SURG, V120, P1551, DOI 10.1097/01.prs.0000282098.61498.ee
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NR 24
TC 3
Z9 6
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2021
VL 86
IS 1
BP 62
EP 66
DI 10.1097/SAP.0000000000002442
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PG4NX
UT WOS:000599714800014
PM 32487808
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Zhao, EY
   Chen, MT
   Yang, H
   Ba, XQ
   Xu, LG
AF Zhao, Eryang
   Chen, Mantao
   Yang, Hu
   Ba, Xiaoqun
   Xu, Ligong
TI Multidisciplinary collaborative treatment of a giant malignant
   peripheral nerve sheath tumor on the top of the head: a case report
SO DISCOVER ONCOLOGY
LA English
DT Article
DE Malignant peripheral nerve sheath tumors (MPNSTs); Surgical resection;
   Case report
ID NECK
AB BackgroundMalignant peripheral nerve sheath tumors (MPNSTs) rarely occur on the top of the head. MPNSTs are usually characterized by invasiveness, recurrence, and metastasis.Case presentationHerein we report a 44-year-old female patient who received multidisciplinary collaborative treatment for a giant MPNST on the top of her head. The patient was initially evaluated in the Departments of Neurosurgery and Burn Plastic Surgery at our hospital. She then underwent elective surgery after psychological counseling. Surgeons from the Departments of Neurosurgery and Burn Plastic Surgery collaborated during the surgery. Specifically, surgeons from the Department of Neurosurgery excised the lesion with meticulous hemostasis under general anesthesia. Then, surgeons from the Department of Burn Plastic Surgery performed personalized skin grafting following a predetermined regimen, which consisted of the following steps: a razor-thin graft was harvested from the anterior thigh and transplanted to the target site to repair the scalp defect; and vacuum sealing drainage was performed. The patient was followed for 6 months postoperatively and had no signs of a recurrence. The patient was very satisfied with the treatment and outcome.ConclusionsComplete surgical resection is recommended for a giant MPNST on the top of the head. Patients should undergo a comprehensive evaluation of disease severity, general health status, and mental state preoperatively. The treatment regimen can be personalized through a multidisciplinary approach. Intraoperative blood loss should be closely monitored, along with regular postoperative follow-up evaluations to confirm treatment efficacy.
C1 [Zhao, Eryang] Shaoxing Univ Arts & Sci, Xinchang Cty Peoples Hosp, Dept Neurosurg, Xinchang Hosp, Shaoxing 312500, Peoples R China.
   [Chen, Mantao] Zhejiang Univ, Dept Neurosurg, Coll Med, Hosp 1, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China.
   [Yang, Hu] Zhejiang Univ, Dept Plast Surg, Hosp 1, Hangzhou 310000, Peoples R China.
   [Ba, Xiaoqun] Zhejiang Univ, Pathol Dept, Hosp 1, Hangzhou 310000, Peoples R China.
   [Xu, Ligong] Zhejiang Univ, Radiol Dept, Hosp 1, Hangzhou 310000, Peoples R China.
C3 Shaoxing University; Zhejiang University; Zhejiang University; Zhejiang
   University; Zhejiang University
RP Chen, MT (通讯作者)，Zhejiang Univ, Dept Neurosurg, Coll Med, Hosp 1, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China.
EM chenmantao0513@163.com
CR Devauchelle B, 2006, LANCET, V368, P203, DOI 10.1016/S0140-6736(06)68935-6
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NR 18
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
EI 2730-6011
J9 DISCOV ONCOL
JI Discov. Oncol.
PD MAY 10
PY 2025
VL 16
IS 1
AR 719
DI 10.1007/s12672-025-02554-8
PG 8
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA 2PC4Q
UT WOS:001487944200007
PM 40348863
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, S
   Zhou, ZM
   Xu, J
AF Zhang, Shuo
   Zhou, Zimo
   Xu, Jing
TI Undifferentiated pleomorphic sarcoma of the lateral thigh with KRAS/NF1
   co-mutation recurred after repetitive surgical resection: A case report
   and review of the literature
SO FRONTIERS IN SURGERY
LA English
DT Review
DE undifferentiated pleomorphic sarcoma; recurrence; KRAS; NF1; case report
ID MALIGNANT FIBROUS HISTIOCYTOMA; ATYPICAL FIBROXANTHOMA
AB Undifferentiated pleomorphic sarcoma (UPS), a rare soft tissue sarcoma subtype, mainly occurs in the deep parts of the limbs and trunk, observed as rapidly growing painless lumps, rarely located under the skin or protrudes from the skin surface. The risk of recurrence and metastasis is associated with multiple factors. Mutation of tumor gene, tumor occurrence, location and depth of invasion, and tumor size have great influence on prognosis. In this study, we described a case of UPS with KRAS/NF1 co-mutation. This case had undergone UPS extended resection for four times combined with chemotherapy in another hospital. The resection area was more than 3 cm, and tumor relapsed after all operations. This time, the tumor protruded from the left lateral surface with ulceration and infection. Due to multiple surgeries, the anatomy of the lateral femoral vessels has been seriously damaged. We performed expanded tumor resection and adjacent flap transfer repair; meanwhile, vacuum sealing drainage (VSD)-negative pressure closed the drainage, and the patient recovered well after surgery. After surgery, the patient was transferred to the Department of Oncology for chemotherapy. There was no recurrence after 6 months of follow-up. Gene mutation plays an important role in UPS recurrence and metastasis. At the same time, occurrence and location, depth, and size of UPS have great influence on the prognosis. Deeper exploration and expanded resection are important for the prognosis of UPS.
C1 [Zhang, Shuo; Xu, Jing] Bengbu Med Coll, Affiliated Hosp 1, Dept Plast Surg, Bengbu, Peoples R China.
   [Zhou, Zimo] China Med Univ, Shengjing Hosp, Dept Orthoped, Shenyang, Peoples R China.
C3 Bengbu Medical University; China Medical University
RP Xu, J (通讯作者)，Bengbu Med Coll, Affiliated Hosp 1, Dept Plast Surg, Bengbu, Peoples R China.
EM xj.69@163.com
RI ; Zhou, Zimo/AAD-3815-2021
OI 张, 硕/0000-0003-4223-3411; Zhou, Zimo/0000-0003-0670-9419
FU Natural Science Research Key Project of Anhui Province;  [KJ2020A0576]
FX This work was supported by grants from the Natural Science Research Key
   Project of Anhui Province (Grant No. KJ2020A0576).
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NR 19
TC 2
Z9 2
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD OCT 21
PY 2022
VL 9
AR 842054
DI 10.3389/fsurg.2022.842054
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5Z2TU
UT WOS:000879830800001
PM 36338647
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Duan, J
   Zhang, CC
   Che, XS
   Fu, JJ
   Pang, F
   Zhao, QG
   You, ZQ
AF Duan, Jing
   Zhang, Chuncheng
   Che, Xiaoshuang
   Fu, Juanjuan
   Pang, Feng
   Zhao, Qigang
   You, Zhiqing
TI Detection of aerobe-anaerobe mixed infection by metagenomic
   next-generation sequencing in an adult suffering from descending
   necrotizing mediastinitis
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Descending necrotizing mediastinitis; mNGS; Aerobe-anaerobe mixed
   infection
ID MANAGEMENT
AB Background Descending necrotizing mediastinitis (DNM) is one of the most virulent forms of mediastinitis. The main causes of high mortality in DNM are believed to stem from difficulty and delay in the diagnosis. Fast and accurate identification of pathogens is important for the treatment of these patients. Metagenomics next-generation sequencing (mNGS) is a powerful tool to identify all kinds of pathogens, especially for rare and complex infections. Case presentation A 64-year-old male patient was admitted to the intensive care unit (ICU) with unconsciousness, dyspnea, and swelling in the mandible and neck. Computed tomography (CT) scan results combined with clinical laboratory examination indicated DNM. Vancomycin and imipenem were used, and vacuum sealing drainage was applied for debridement and drainage of the infected area. The positive mNGS results of drainage fluid confirmed the presence of mixed infection caused by Streptococcus anginosus, Prevotella oris, and several other anaerobes. The antibiotics were adjusted to piperacillin/tazobactam and tinidazole according to the mNGS results and antimicrobial susceptibility testing of cultured pathogens. After 11 days of antibiotic therapy, the infection symptoms of the neck and mediastinum improved, and the patient was transferred out of the ICU on the 26(th) day after negative result of drainage fluid culture. Conclusion This case suggested that mNGS is a promising technology for precise and fast pathogens identification with high sensitivity, which may guide the diagnosis of infectious diseases in the future trend.
C1 [Duan, Jing; Fu, Juanjuan; Pang, Feng; Zhao, Qigang; You, Zhiqing] Liaocheng Peoples Hosp, Dept Clin Lab, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
   [Zhang, Chuncheng] Liaocheng Peoples Hosp, Dept Hepatobiliary Surg, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
   [Che, Xiaoshuang] Liaocheng Peoples Hosp, Dept Computed Tomog, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
RP You, ZQ (通讯作者)，Liaocheng Peoples Hosp, Dept Clin Lab, 67 Dongchangxi Rd, Liaocheng 252000, Shandong, Peoples R China.
EM txt19876@163.com
OI You, Zhiqing/0000-0002-5242-5233; Pang, Feng/0000-0002-7098-0353
FU Medicine and Health Science Technology Development Plan of the Shandong
   Province of China [2016WS0217]
FX The work was supported by the corresponding author of this paper. The
   article-processing and language editing services of this study were
   supported by the Medicine and Health Science Technology Development Plan
   of the Shandong Province of China (Grant Number 2016WS0217).
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NR 15
TC 4
Z9 6
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD SEP 3
PY 2021
VL 21
IS 1
AR 905
DI 10.1186/s12879-021-06624-4
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA UN7ZN
UT WOS:000694229700006
PM 34479479
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, RH
   Wang, ZJ
   Huang, WZ
   Zhao, YH
   Xu, LS
   Yu, SB
AF Yang, Ronghua
   Wang, Zhijun
   Huang, Wenzhu
   Zhao, Yuhuan
   Xu, Lusheng
   Yu, Shaobin
TI A Suitable Option for Gustilo and Anderson Grade III Injury
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE General Surgery; Internal Medicine; Vacuum drainage (VSD)
ID NEGATIVE-PRESSURE THERAPY; TIBIAL SHAFT FRACTURES; SOFT-TISSUE DEFECTS;
   LOWER-EXTREMITIES; WOUND THERAPY; RECONSTRUCTION; DEBRIDEMENT;
   MANAGEMENT; INFECTION
AB Background: The management of Gustilo and Anderson grade III injury remains difficult, particularly due to the incidence of wound infections, delayed fracture union, and traumatic extremity amputation. However, little data is available on delayed skin graft or flap reconstructions of Gustilo grade III injury, especially using new technologies of wound coverage, such as vacuum sealing drainage (VSD) combined with limited internal and/or external fixation.
   Material/Methods: Between June 2008 and May 2013, we performed the VSD technique combined with limited internal and/or external fixation on 38 patients (22 males and 16 females, with a mean age of 36.5 years) with Gustilo and Anderson grade III injury. VSD was regularly changed and delayed skin grafts or flaps were used to cover the defect. Two patients were lost to follow-up, and the remaining 36 were available for evaluation. The complications, wound healing, infections, and bony union were assessed for a mean duration of 2.5 years (range, 1-4 years).
   Results: Complications were seen in 5 of the 36 cases: 2 cases had infection alone, 1 case had delayed union or nonunion, 1 case had infection and delayed union, and 1 case had wound necrosis, infection, and nonunion. VSD was regularly changed 2-6 times. Morphological appearance and functional recovery were satisfactory in all cases.
   Conclusions: Using VSD before skin grafts or flaps coverage, combined with limited internal and/or external fixation, is a suitable option for Gustilo and Anderson grade III injury.
C1 [Yang, Ronghua] First Peoples Hosp Foshan, Dept Burn & Plast Surg, Foshan, Guangdong, Peoples R China.
   [Wang, Zhijun; Huang, Wenzhu] First Peoples Hosp Foshan, Dept Rehabil Med, Foshan, Guangdong, Peoples R China.
   [Zhao, Yuhuan] First Peoples Hosp Foshan, Dept Internal Med, Foshan, Guangdong, Peoples R China.
   [Xu, Lusheng; Yu, Shaobin] First Peoples Hosp Foshan, Dept Hand & Foot Plast Surg, Foshan, Guangdong, Peoples R China.
RP Yu, SB (通讯作者)，First Peoples Hosp Foshan, Dept Hand & Foot Plast Surg, Foshan, Guangdong, Peoples R China.
EM 1215601309@qq.com
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NR 21
TC 6
Z9 9
U1 0
U2 8
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 26
PY 2016
VL 22
DI 10.12659/MSM.896009
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DU2FR
UT WOS:000382027100002
PM 27564219
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Xing, H
   Pan, JL
   Liu, H
   Wang, YN
   Chang, ZQ
AF Xing, Hao
   Pan, Junlin
   Liu, Huan
   Wang, Yanan
   Chang, Zhengqi
TI Preliminary research indicates that mechanical force through Pioze1
   enhances local immunity during NPWT treatment for spinal infections
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE spinal infection; negative pressure wound therapy; Piezo1; mechanical
   force; immune response
ID PRESSURE WOUND THERAPY; PYOGENIC SPONDYLODISCITIS
AB Objective This study aims to investigate the mechanism by which Negative Pressure Wound Therapy (NPWT) regulates local immune responses in spinal infection through Piezo1-mediated mechanical stress, and elucidate its potential role in the treatment of spinal infections. Methods From July 2021 to April 2022, a total of 7 patients with spinal infection treated with NPWT at our department were included in the study. The study analyzed clinical outcomes of spinal infection surgeries, including operative duration, intraoperative blood loss, postoperative drainage, improvements in pain levels as measured by the Visual Analogue Scale (VAS), and inflammatory markers such as C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR) measured one week before and after the procedure. Additionally, healing times and recurrence rates within two years post-surgery were assessed. In addition, lesion specimens were retained during surgery and changes in Piezo1, Interleukin-1 beta (IL-1 beta), IL-6, IL-8, and Tumor Necrosis Factor-alpha (TNF-alpha) in lesion tissues were observed before and after immunohistochemical analysis. Results All 7 patients with spinal infections successfully underwent NPWT treatment and were ultimately cured. The average healing time was 45.71 +/- 9.49 days, and there were no cases of recurrence or death during the two-year follow-up period. Surgical data showed a surgery duration of 96.57 +/- 13.31 minutes, intraoperative blood loss of 65.71 +/- 29.36 milliliters, and postoperative drainage of 163.57 +/- 11.07 milliliters. Postoperatively, CRP, ESR, and VAS all significantly improved compared to preoperative levels (all p<0.05), which was superior to traditional treatment methods. Following NPWT intervention, the expression of Piezo1 protein at the lesion site significantly increased (0.03 +/- 0.11 vs. 0.27 +/- 0.22; p<0.05), while the expression levels of IL-1 beta, IL-6, IL-8, and TNF-alpha in the local immune microenvironment of the infected lesion significantly decreased (0.26 +/- 0.11 vs. 0.16 +/- 0.09, 0.27 +/- 0.12 vs. 0.15 +/- 0.67, 0.26 +/- 0.18 vs. 0.10 +/- 0.12, 0.35 +/- 0.21 vs. 0.15 +/- 0.11; p<0.05). Conclusion Clinical results demonstrate that NPWT treatment for spinal infections exhibits remarkable efficacy, accompanied by a notable augmentation in local Piezo1 protein consistency. It is hypothesized that the mechanical force employed in NPWT treatment stimulates the Piezo1 protein, thereby modulating local immune cells and factors, ultimately bolstering local immunity. This study not only provides a molecular biology basis for a deeper understanding of the therapeutic effects of NPWT, but also offers new insights for optimizing treatment strategies for spinal infections.
C1 [Xing, Hao; Liu, Huan; Wang, Yanan; Chang, Zhengqi] 960th Hosp Peoples Liberat Army China PLA, Dept Orthopaed, Jinan, Peoples R China.
   [Pan, Junlin] 960th Hosp Peoples Liberat Army China PLA, Dept Reprod Med, Jinan, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp Peoples Liberat Army China PLA, Dept Orthopaed, Jinan, Peoples R China.
EM 26766771@qq.com
RI hao, xing/ACN-7926-2022
FU Natural Science Foundation of Shandong Province [ZR2023MH331]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This research was supported
   by Natural Science Foundation of Shandong Province (Award Number:
   ZR2023MH331; Grant Recipient: Zhengqi Chang).
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NR 38
TC 2
Z9 2
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 3
PY 2025
VL 16
AR 1600194
DI 10.3389/fimmu.2025.1600194
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 3UH0L
UT WOS:001509165900001
PM 40529353
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kominiarek, MA
   Espinal, M
   Cassimatis, IR
   Peace, JM
   Premkumar, A
   Toledo, P
   Shramuk, M
   Wafford, EQ
AF Kominiarek, Michelle A.
   Espinal, Mariana
   Cassimatis, Irina R.
   Peace, Jack M.
   Premkumar, Ashish
   Toledo, Paloma
   Shramuk, Maxwell
   Wafford, Eileen Q.
TI Peripartum interventions for people with class III obesity: a systematic
   review and meta-analysis
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Review
DE Key words: anticoagulation; body mass index; cesarean delivery
   techniques; induction of labor; prophylactic antibiotics; wound
   complications
ID PRESSURE WOUND THERAPY; SURGICAL-SITE INFECTION; CESAREAN DELIVERY;
   WOMEN; COMPLICATIONS; SECTION; LABOR; RISK; MANAGEMENT; PREGNANCY
AB OBJECTIVE: This study aimed to identify evidence-based peripartum interventions for people with a body mass index >= 40 kg/m 2 . DATA SOURCES: PubMed, MEDLINE, EMBASE, Cochrane, CINAHL, and ClinicalTrials.gov were searched from inception to 2022 without date, publication type, or language restrictions. STUDY ELIGIBILITY CRITERIA: Cohort and randomized controlled trials that implemented an intervention and evaluated peripartum outcomes of people with a body mass index >= 40 kg/m 2 were included. The primary outcome depended on the intervention but was commonly related to wound morbidity after cesarean delivery (ie, infection, separation, hematoma). METHODS: Meta-analysis was completed for interventions with at least 2 studies. Pooled risk ratios with 95% con fidence intervals and heterogeneity (I 2 statistics) were reported. RESULTS: Of 20,301 studies screened, 30 studies (17 cohort and 13 randomized controlled trials) encompassing 10 types of interventions were included. The interventions included delivery planning (induction of labor, planned cesarean delivery), antibiotics during labor induction or for surgical prophylaxis, 6 types of cesarean delivery techniques, and anticoagulation dosing after a cesarean delivery. Planned cesarean delivery compared with planned vaginal delivery did not improve outcomes according to 3 cohort studies. One cohort study compared 3 g with 2 g of cephazolin prophylaxis for cesarean delivery and found no differences in surgical site infections. According to 3 cohort studies and 2 randomized controlled trials, there was no improvement in outcomes with a non -low transverse skin incision. Ten studies (4 cohort and 6 randomized controlled trials) met the inclusion criteria for the meta-analysis. Two randomized controlled trials compared subcuticular closure with suture vs staples after cesarean delivery and found no differences in wound morbidity within 6 weeks of cesarean delivery (n=422; risk ratio, 1.09; 95% con fidence interval, 0.75 -1.59; I-2 =9%). Prophylactic negative-pressure wound therapy was compared with standard dressing in 4 cohort and 4 randomized controlled trials, which found no differences in wound morbidity (cohort n=2200; risk ratio, 1.19; 95% con fidence interval, 0.88 -1.63;I-2 =66.1%) or surgical site infections (randomized controlled trial n=1262; risk ratio, 0.90; 95% con fidence interval, 0.63 -1.29;I-2 =0). CONCLUSION: Few studies address interventions in people with a body mass index >= 40 kg/m(2) , and most studies did not demonstrate a bene fit. Either staples or suture are recommended for subcuticular closure, but available data do not support prophylactic negative-pressure wound therapy after cesarean delivery for people with a body mass index >= 40 kg/m(2) .
C1 [Kominiarek, Michelle A.; Espinal, Mariana] Northwestern Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Feinberg Sch Med, Chicago, IL 60208 USA.
   [Cassimatis, Irina R.] Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Portland, OR USA.
   [Peace, Jack M.] Temple Univ, Dept Anesthesiol, Lewis Katz Sch Med, Philadelphia, PA USA.
   [Premkumar, Ashish] Univ Chicago, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chicago, IL USA.
   [Toledo, Paloma] Univ Miami, Dept Anesthesiol, Miami, FL USA.
   [Shramuk, Maxwell] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL USA.
   [Wafford, Eileen Q.] Northwestern Univ, Galter Hlth Sci Lib & Learning Ctr, Feinberg Sch Med, Chicago, IL USA.
C3 Northwestern University; Feinberg School of Medicine; Oregon Health &
   Science University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; University of Chicago; University of Miami;
   Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine
RP Kominiarek, MA (通讯作者)，Northwestern Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Feinberg Sch Med, Chicago, IL 60208 USA.
EM mkominia@nm.org
OI Cassimatis, Irina/0000-0002-0385-9502; Wafford, Q.
   Eileen/0000-0001-5228-8219; Premkumar, Ashish/0000-0001-6952-9955;
   kominiarek, michelle/0000-0003-0064-2399; Shramuk,
   Max/0009-0000-7453-2948
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NR 55
TC 5
Z9 6
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD MAY
PY 2024
VL 6
IS 5
AR 101354
DI 10.1016/j.ajogmf.2024.101354
EA APR 2024
PG 16
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SM2D3
UT WOS:001234795200001
PM 38494155
DA 2026-07-24
ER

PT J
AU Roberts, DJ
   Leppäniemi, A
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AF Roberts, Derek J.
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TI The open abdomen in trauma, acute care, and vascular and endovascular
   surgery: comprehensive, expert, narrative review
SO BJS OPEN
LA English
DT Review
ID ABDOMINAL COMPARTMENT SYNDROME; MEDIATED FASCIAL TRACTION;
   DAMAGE-CONTROL LAPAROTOMY; PRESSURE WOUND THERAPY; POSTERIOR COMPONENT
   SEPARATION; AORTIC-ANEURYSM; CRITICALLY-ILL; INTRAABDOMINAL
   HYPERTENSION; ENTEROATMOSPHERIC FISTULAS; PERITONEAL RESUSCITATION
AB Background The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular surgery.Methods A group of 12 international trauma, acute care, and vascular and endovascular surgery experts were invited to review current literature and important concepts surrounding the open abdomen.Results The open abdomen may be classified using validated systems developed by a working group in 2009 and modified by the World Society of the Abdominal Compartment Syndrome-The Abdominal Compartment Society in 2013. It may be indicated in major trauma, intra-abdominal sepsis, vascular surgical emergencies, and severe acute pancreatitis; to facilitate second look laparotomy or avoid or treat abdominal compartment syndrome; and when the abdominal wall cannot be safely closed. Temporary abdominal closure and staged abdominal reconstruction methods include a mesh/sheet, transabdominal wall dynamic fascial traction, negative pressure wound therapy, and hybrid negative pressure wound therapy and dynamic fascial traction. This last method likely has the highest primary fascial closure rates. Direct peritoneal resuscitation is currently an experimental strategy developed to improve primary fascial closure rates and reduce complications in those with an open abdomen. Primary fascial closure rates may be improved by early return to the operating room; limiting use of crystalloid fluids during the surgical interval; and preventing and/or treating intra-abdominal hypertension, enteric fistulae, and intra-abdominal collections after surgery. The majority of failures of primary fascial closure and enteroatmospheric fistula formation may be prevented using effective temporary abdominal closure techniques, providing appropriate resuscitation fluids and nutritional support, and closing the abdomen as early as possible.Conclusion Subsequent stages of the innovation of the open abdomen will likely involve the design and conduct of prospective studies to evaluate appropriate indications for its use and effectiveness and safety of the above components of open abdomen management.
   The open abdomen is an innovation that greatly improved surgical understanding of temporary abdominal closure indications, techniques, and outcomes. We provide an evidence-informed, expert, comprehensive narrative review of the open abdomen. Subsequent stages of the innovation of the open abdomen will likely involve the design and conduct of prospective studies to evaluate appropriate indications for its use and effectiveness and safety of the above components of open abdomen management.
C1 [Roberts, Derek J.] Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa, ON, Canada.
   [Roberts, Derek J.] Ottawa Hosp, Ottawa, ON, Canada.
   [Roberts, Derek J.] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Roberts, Derek J.] Ottawa Hosp, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
   [Leppaniemi, Ari; Tolonen, Matti; Mentula, Panu] Helsinki Univ Hosp, Abdominal Ctr, Dept Abdominal Surg, Helsinki, Finland.
   [Leppaniemi, Ari; Tolonen, Matti; Mentula, Panu] Univ Helsinki, Helsinki, Finland.
   [Bjorck, Martin] Uppsala Univ, Dept Surg Sci, Vasc Surg, Uppsala, Sweden.
   [Kirkpatrick, Andrew W.] TeleMentored Ultrasound Supported Med Intervent T, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Univ Calgary, Dept Surg, Calgary, AB, Canada.
   [Kirkpatrick, Andrew W.] Univ Calgary, Dept Crit Care Med, Calgary, AB, Canada.
   [Sugrue, Michael] Univ Hosp Donegal, Dept Surg Letterkenny, Donegal, Ireland.
   [Pereira, Bruno M.] Vassouras Univ, Masters Program Hlth Appl Sci, Dept Surg, Vassouras, RJ, Brazil.
   [Pereira, Bruno M.] Campinas Holy House Gen Surg Residency Program, Dept Surg, Campinas, SP, Brazil.
   [Petersson, Ulf] Skane Univ Hosp, Dept Surg, Malmo, Sweden.
   [Petersson, Ulf] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [Coccolini, Federico] Pisa Univ Hosp, Dept Gen Emergency & Trauma Surg, Pisa, Italy.
   [Latifi, Rifat] Westchester Med Ctr, Dept Surg, Valhalla, NY USA.
C3 University of Ottawa; University of Ottawa; Ottawa Hospital Research
   Institute; University of Ottawa; University of Ottawa; Ottawa Hospital
   Research Institute; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; Uppsala University; University of
   Calgary; University of Calgary; Lund University; Skane University
   Hospital; Lund University; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Westchester Medical Center
RP Leppäniemi, A (通讯作者)，Meilahti Tower Hosp, Haartmaninkatu 4, HUS-00029 Helsinki, Finland.
EM Leppis54@outlook.com
RI Coccolini, Federico/AAJ-6507-2020; Mentula, Panu/H-9025-2019; , Pereira
   BM/D-4542-2015; Latifi, Rifat/JPX-2945-2023; Leppäniemi,
   Ari/GQZ-7991-2022; Roberts, Derek/L-6229-2019; Tolonen,
   Matti/I-9970-2019
OI Coccolini, Federico/0000-0001-6364-4186; Mentula,
   Panu/0000-0002-6516-3797; , Pereira BM/0000-0003-3763-1749; 
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NR 135
TC 27
Z9 41
U1 2
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD SEP 5
PY 2023
VL 7
IS 5
AR zrad084
DI 10.1093/bjsopen/zrad084
PG 17
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W1MR4
UT WOS:001089344100001
PM 37882630
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Miller, T
   Clark, J
AF Miller, Taylor
   Clark, Jaclyn
TI Advanced Wound Care Strategies in Patients with NSTIs
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE wound care; wound healing; necrotizing soft tissue infections;
   postoperative care; surgical wound infections
ID HYPERBARIC-OXYGEN TREATMENT; DIABETIC FOOT; PREVENTION; MANAGEMENT;
   DRESSINGS; GUIDELINE
AB Necrotizing soft tissue infections (NSTIs) are rapidly progressive, life-threatening infections associated with significant morbidity and mortality. Surgical debridement, the cornerstone of treatment, often results in extensive, complex wounds located in anatomically difficult regions. Management of these wounds can be challenging, especially for surgeons with limited experience in complex wound care and reconstruction. Yet, proper management of these wounds is critical to patient recovery and long-term quality of life. This review provides a comprehensive overview of current strategies in NSTI wound reconstruction. It begins by outlining the biological underpinnings of wound healing and the unique challenges posed by NSTI-related wounds. The review then explores a range of dressing materials and advanced wound care modalities, including negative pressure wound therapy, cellular and tissue-based products, and hyperbaric therapy. Finally, it presents a guide to surgical reconstruction techniques, including skin grafting and flap coverage. By consolidating current knowledge and practical guidance, this review seeks to support generalist and acute care surgeons with the knowledge needed to optimize wound healing, enhance functional outcomes, and improve quality of life for NSTI survivors.
C1 [Miller, Taylor; Clark, Jaclyn] R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Miller, T (通讯作者)，R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
EM taylor.miller@umm.edu; jaclyn.clark@som.umaryland.edu
OI Miller, Taylor/0000-0003-0342-4768
CR academic.oup, Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases|Oxford Academic
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NR 48
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 17
PY 2025
VL 14
IS 10
AR 3514
DI 10.3390/jcm14103514
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3CD8H
UT WOS:001496828200001
PM 40429509
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Fuchs, N
   Pavljak, L
   Hauptman, D
   Mance, M
AF Fuchs, Nino
   Pavljak, Lucija
   Hauptman, Dinko
   Mance, Marko
TI Two-Stage Surgical Management of Anogenital Hidradenitis Suppurativa in
   Patients on Biologic Therapy: A Retrospective Case Series
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE anogenital region; biologic therapy; hidradenitis suppurativa; two-stage
   surgery
ID PRESSURE WOUND THERAPY
AB Hidradenitis suppurativa is a chronic inflammatory skin disorder causing painful nodules, abscesses and scarring, with the anogenital region presenting particular functional and reconstructive challenges. Although biologic therapy is commonly used in moderate to severe disease, its limitations highlight the role of surgery in advanced cases. This single-centre retrospective case series included five male patients with Hurley stage III perineal, anorectal, genital or gluteal disease treated surgically between 2021 and 2023 following failure of biologic therapy. Management consisted of two-stage radical excision, negative-pressure wound therapy and reconstruction with meshed split-thickness skin grafts. All patients achieved more than 90% graft take and complete wound healing. No recurrence occurred during a median follow-up of 19.2 months. One patient developed a keloid scar at the donor site, and one experienced delayed healing. Functional and aesthetic results were satisfactory in all cases. Two-stage surgical excision with split-thickness skin graft reconstruction was associated with sustained wound healing and favourable functional outcomes in selected patients with severe anogenital hidradenitis suppurativa refractory to biologic therapy.
C1 [Fuchs, Nino; Pavljak, Lucija; Mance, Marko] Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
   [Pavljak, Lucija] Gen Hosp, Dept Vasc & Plast Surg & Urol, Koprivnica, Croatia.
   [Hauptman, Dinko] Univ Ctr Zagreb, Dept Urol, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb Hospital; University of
   Zagreb
RP Pavljak, L (通讯作者)，Univ Hosp Ctr Zagreb, Dept Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.; Pavljak, L (通讯作者)，Gen Hosp, Dept Vasc & Plast Surg & Urol, Koprivnica, Croatia.
EM lucija.pavljak@student.mef.hr
CR Abbvie, HUMIRA ADALIMUMAB
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 26
PY 2026
VL 23
IS 4
AR e70874
DI 10.1111/iwj.70874
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO9DZ
UT WOS:001723912700001
PM 41884971
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, FX
   Li, L
   Li, WZ
   Ni, XB
   Pan, Z
   Ying, LL
   Zhu, MN
AF Wang, Feixia
   Li, Lu
   Li, Weizhen
   Ni, Xiaobo
   Pan, Zhe
   Ying, Lingling
   Zhu, Mina
TI Clinical characteristics, treatment, and wound management of pyoderma
   gangrenosum: A case series
SO PLOS ONE
LA English
DT Article
AB Objective This study aimed to evaluate the clinical characteristics, diagnostic processes, therapeutic approaches, and wound management strategies for patients diagnosed with pyoderma gangrenosum (PG), a rare inflammatory skin condition often resulting in misdiagnosis and treatment delays.Methods A case series was conducted involving patients diagnosed with PG at the author's Hospital, from January 1, 2020 to April 3, 2023. Data on patient demographics, wound characteristics, treatment methodologies, and wound care experiences were collected and analyzed.Results The study included nine male patients with a mean age of 48.6 years (median 50 years). All patients were initially misdiagnosed, predominantly as skin infections or cellulitis. Lesions were mainly located on the lower extremities, with ulcerative PG being the most common subtype. Seven patients had skin injuries preceding PG onset. Treatment included systemic glucocorticoids and comprehensive wound care approaches. Three patients required additional interventions, like negative pressure wound therapy. Ultimately, six patients healed, while three died due to severe comorbidities or septic shock.Conclusion PG is frequently misdiagnosed and often presents as ulcerative lesions triggered by skin injuries. Effective management, including systemic glucocorticoids and focused wound care, can significantly improve patient outcomes.
C1 [Wang, Feixia; Li, Lu; Li, Weizhen; Ni, Xiaobo; Pan, Zhe; Ying, Lingling; Zhu, Mina] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Nursing Dept, Hangzhou, Peoples R China.
C3 Zhejiang University
RP Wang, FX (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Sch Med, Nursing Dept, Hangzhou, Peoples R China.
EM 1299038@zju.edu.cn
RI Wang, Feixia/MCJ-4335-2025
OI Wang, Feixia/0009-0004-2416-4971
CR Becker SL, 2025, J INVEST DERMATOL, V145, P1305, DOI [10.1016/j.jid.2024.09.023, 10.1016/j.jid.2024.09.023]
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   Zaman M, 2024, ARCH DERMATOL RES, V316, DOI 10.1007/s00403-024-03332-2
NR 27
TC 2
Z9 2
U1 1
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2025
VL 20
IS 6
AR e0326203
DI 10.1371/journal.pone.0326203
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4BE8L
UT WOS:001513865300050
PM 40549753
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Taylor, CJ
   Chester, DL
   Jeffery, SL
AF Taylor, Christopher J.
   Chester, Darren L.
   Jeffery, Steven L.
TI Functional Splinting of Upper Limb Injuries With Gauze-Based Topical
   Negative Pressure Wound Therapy
SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME
LA English
DT Article
DE Functional splinting; hand injury; topical negative pressure;
   war-related injury
ID RECONSTRUCTION
AB Complex hand injuries can be difficult to dress effectively and achieve adequate splintage of the hand in a functional position. During the past 7 years, we have had a great deal of success with topical negative-pressure dressings in the management of complex blast-related extremity war injuries. We have more recently changed to using a gauze-based system and have found this particularly useful in dressing complex hand injuries. We have been able to use this vacuum dressing system to splint the hand in a position of function. This provides an easily applied dressing that, through topical negative pressure, promotes wound healing and ensures a resting functional position, thus minimizing postoperative stiffness. We have not been able to achieve this as efficiently with standard dressings and plaster-of-Paris casts. This article details the technique of functional splinting of complex hand injuries using a gauze-based, topical negative-pressure dressing system. (J Hand Surg 2011;36A:1848-1851. (C) 2011 Published by Elsevier Inc. on behalf of the American Society for Surgery of the Hand.)
C1 [Taylor, Christopher J.; Chester, Darren L.; Jeffery, Steven L.] Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England.
C3 University of Birmingham
RP Taylor, CJ (通讯作者)，New Queen Elizabeth Hosp, Dept Reconstruct Plast Surg, Mindelsohn Way, Birmingham B15 2WB, W Midlands, England.
EM christaylor@doctors.org.uk
RI jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412
CR Ahearn C, 2009, OSTOMY WOUND MANAG, V55, P22
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
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   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Kumar AR, 2009, PLAST RECONSTR SURG, V123, P218, DOI 10.1097/PRS.0b013e3181904da9
   Webb LX, 2008, J ORTHOP TRAUMA, V22, pS135, DOI 10.1097/BOT.0b013e31818956ce
NR 13
TC 12
Z9 13
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0363-5023
J9 J HAND SURG-AM
JI J. Hand Surg.-Am. Vol.
PD NOV
PY 2011
VL 36A
IS 11
BP 1848
EP 1851
DI 10.1016/j.jhsa.2011.08.023
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 846TR
UT WOS:000296926600019
PM 22036283
DA 2026-07-24
ER

PT J
AU Wei, D
   Zhu, XM
   Chen, YY
   Li, XY
   Chen, YP
   Liu, HY
   Zhang, M
AF Wei, Di
   Zhu, Xiao-Mei
   Chen, Yong-Yi
   Li, Xu-Ying
   Chen, Yu-Pan
   Liu, Hua-Yun
   Zhang, Min
TI Chronic wound biofilms: diagnosis and therapeutic strategies
SO CHINESE MEDICAL JOURNAL
LA English
DT Review
DE Biofilm; Chronic wound; Diagnosis; Therapy
ID DIABETIC FOOT ULCERS; NEGATIVE-PRESSURE; ANTIBACTERIAL ACTIVITY;
   STAPHYLOCOCCUS-AUREUS; DEBRIDEMENT; INFECTIONS; MICROSCOPY; GUIDELINES;
   CARE; SKIN
AB Objective: To review the diagnosis of chronic wound biofilms and discuss current treatment approaches. Data sources: Articles included in this review were obtained from the following databases: Wanfang, China National Knowledge Infrastructure, PubMed, and the Web of Science. We focused on research published before August 2019 with keywords including chronic wound, biofilm, bacterial biofilms, and chronic wound infection. Study selection: Relevant articles were selected by carefully reading the titles and abstracts. Further, different diagnosis and clinical treatment methods for chronic wound biofilm were compared and summarized from the selected published articles. Results: Recent guidelines on medical biofilms stated that approaches such as the use of scanning electron microscopy and confocal laser scanning microscopy are the most reliable types of diagnostic techniques. Further, therapeutic strategies include debridement, negative pressure wound therapy, ultrasound, antibiotic, silver-containing dressing, hyperbaric oxygen therapy, and others. Conclusion: This review provides the identification and management of biofilms, and it can be used as a tool by clinicians for a better understanding of biofilms and translating research to develop best clinical practices.
C1 [Wei, Di; Zhu, Xiao-Mei; Chen, Yu-Pan; Liu, Hua-Yun] Cent S Univ, Hunan Canc Hosp, Dept Wound Ost Continence, Nursing Ctr,Affiliated Canc Hosp,Xiangya Sch Med, 283 Rd Tongzipo, Changsha 410013, Hunan, Peoples R China.
   [Chen, Yong-Yi] Cent S Univ, Hunan Canc Hosp, Dept Hosp Off, Affiliated Canc Hosp,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
   [Li, Xu-Ying; Zhang, Min] Cent S Univ, Hunan Canc Hosp, Nursing Dept, Affiliated Canc Hosp,Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Zhu, XM (通讯作者)，Cent S Univ, Hunan Canc Hosp, Dept Wound Ost Continence, Nursing Ctr,Affiliated Canc Hosp,Xiangya Sch Med, 283 Rd Tongzipo, Changsha 410013, Hunan, Peoples R China.
EM zhuxiaomei@hnca.org.cn
FU Program on Clinical Research Center for Wound Healing in Hunan province
   under the Science and Technology Department of Hunan Province
   [2018SK7005]; Guiding Plan of Clinical Medical Technology Innovation in
   Hunan Province [2018SK50905]; Innovation Platform Program: the
   Introduction of Foreign Intellectual Special in Hunan Province
   [2019YZ3035];  [ZDZX2017ZL-04-HN]
FX This work was supported by grants from the Program on Clinical Research
   Center for Wound Healing in Hunan province funded under the Science and
   Technology Department of Hunan Province (No. 2018SK7005), the Guiding
   Plan of Clinical Medical Technology Innovation in Hunan Province (No.
   2018SK50905), the Innovation Platform Program: the Introduction of
   Foreign Intellectual Special in Hunan Province (No. 2019YZ3035), and
   National Major Special Research (No. ZDZX2017ZL-04-HN).
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NR 81
TC 47
Z9 58
U1 3
U2 90
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD NOV 20
PY 2019
VL 132
IS 22
BP 2737
EP 2744
DI 10.1097/CM9.0000000000000523
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JX5JD
UT WOS:000503770200013
PM 31725458
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Firlar, I
   Altunbek, M
   McCarthy, C
   Ramalingam, M
   Camci-Unal, G
AF Firlar, Ilayda
   Altunbek, Mine
   McCarthy, Colleen
   Ramalingam, Murugan
   Camci-Unal, Gulden
TI Functional Hydrogels for Treatment of Chronic Wounds
SO GELS
LA English
DT Review
DE chronic wounds; wound healing; wound dressings; hydrogels; polymers
ID HYPERBARIC-OXYGEN THERAPY; INJECTABLE HYDROGELS; DRUG-DELIVERY;
   POLY(ETHYLENE GLYCOL); CHITOSAN HYDROGELS; DRESSINGS; ANTIBACTERIAL;
   NANOCOMPOSITE; INFLAMMATION; REGENERATION
AB Chronic wounds severely affect 1-2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.
C1 [Firlar, Ilayda] Univ Massachusetts Lowell, Biomed Engn & Biotechnol Program, Lowell, MA 01854 USA.
   [Firlar, Ilayda; Altunbek, Mine; McCarthy, Colleen; Camci-Unal, Gulden] Univ Massachusetts Lowell, Dept Chem Engn, Lowell, MA 01854 USA.
   [Ramalingam, Murugan] Chengdu Univ, Sch Basic Med Sci, Chengdu 610106, Peoples R China.
   [Ramalingam, Murugan] Dankook Univ, Inst Tissue Regenerat Engn, Cheonan 31116, South Korea.
   [Camci-Unal, Gulden] Univ Massachusetts, Dept Surg, Med Sch, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts Lowell;
   University of Massachusetts System; University of Massachusetts Lowell;
   Chengdu University; Dankook University; University of Massachusetts
   System; University of Massachusetts Worcester
RP Camci-Unal, G (通讯作者)，Univ Massachusetts Lowell, Dept Chem Engn, Lowell, MA 01854 USA.; Camci-Unal, G (通讯作者)，Univ Massachusetts, Dept Surg, Med Sch, Worcester, MA 01605 USA.
EM laydafrla@gmail.com; mine_altunbek@uml.edu; cmmccar@bu.edu;
   rmurug2000@gmail.com; gulden_camciunal@uml.edu
RI Ramalingam, Murugan/AAV-1702-2020
OI Ramalingam, Murugan/0000-0001-6498-9792; Camci-Unal,
   Gulden/0000-0003-4258-844X
FU U.S. Army Medical Research and Development Command (USAMRDC), through
   the Military Burn Research Program (MBRP) [W81XWH-20-1-0521]; National
   Cancer Institute [P30CA008748] Funding Source: NIH RePORTER
FX This work was partially supported by the U.S. Army Medical Research and
   Development Command (USAMRDC), through the Military Burn Research
   Program (MBRP) under Award No. W81XWH-20-1-0521. Opinions,
   interpretations, conclusions, and recommendations are those of the
   author and are not necessarily endorsed by the U.S. Army.
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PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2310-2861
J9 GELS-BASEL
JI Gels
PD FEB
PY 2022
VL 8
IS 2
AR 127
DI 10.3390/gels8020127
PG 23
WC Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Polymer Science
GA 9S6OP
UT WOS:000946457400001
PM 35200508
OA Green Submitted, gold
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Li, YM
   Wu, B
   Liu, YC
AF Li, Yaomin
   Wu, Bei
   Liu, Yancheng
TI The Effect of Negative Pressure Therapy on Closed Wound After the
   Orthopedic Surgery of Lower Limb: A Meta-Analysis
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure therapy; lower limb; orthopedic surgery
ID SURGICAL SITE; PRIMARY HIP; INCISION; KNEE; DRESSINGS; ARTHROPLASTY;
   INFECTION; COMPLICATIONS
AB Background. Negative-pressure wound therapy is applied increasingly to manage closed wounds. However, no consensus has been reached with regard to surgical site infection and wound complication. Aim. To evaluate the effect of negative pressure therapy on closed wounds after orthopedic surgeries. Methods. PubMed, EMBASE, Cochrane Library, and MEDLINE databases were searched from 1966 to January 2019; the references in the identified studies were also searched. Results. Ten studies on arthroplasty and 3 studies on fractures were included. Significantly few infections appeared in the negative pressure group (odds ratio [OR] = 0.28, 95% confidence interval [CI] = 0.18-0.46, P < .001; I-2 = 0%, P = .80). There was no significant difference for other complications (OR = 0.54, 95% CI = 0.21-1.39, P = .20; I-2 = 81%, P < .001). Few patients needed reoperation in the negative pressure group (OR = 0.28, 95% CI = 0.14-0.53, P < .001; I-2 = 0%, P = .82). Conclusion. Negative pressure therapy can decrease surgical site infection and reoperation of closed incisions.
C1 [Li, Yaomin; Wu, Bei; Liu, Yancheng] Tianjin Hosp, Tianjin, Peoples R China.
C3 Tianjin University
RP Li, YM (通讯作者)，Tianjin Hosp, Dept Rehabil, 406 Jiefangnan Rd, Tianjin 300211, Peoples R China.
EM dryaominli@163.com
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NR 19
TC 7
Z9 7
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2020
VL 27
IS 2
BP 165
EP 172
AR 1553350619893222
DI 10.1177/1553350619893222
EA DEC 2019
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KR8AK
UT WOS:000507040900001
PM 31874595
DA 2026-07-24
ER

PT J
AU Xing, W
   Huang, Y
   Yao, J
   Jie, K
   Xu, TL
AF Xing, Wang
   Huang, Yi
   Yao, Jia
   Jie, Kan
   Xu, Tielong
TI Optimized nursing strategies for skin graft outcomes: a narrative review
   of current evidence
SO FRONTIERS IN SURGERY
LA English
DT Review
DE cell therapy; functional rehabilitation; negative pressure wound
   therapy; scar management; skin grafting; wound dressings
ID RANDOMIZED-CONTROLLED-TRIAL; PRESSURE WOUND THERAPY; DIABETIC FOOT
   ULCERS; PLATELET-RICH PLASMA; DONOR SITE WOUNDS; HEALING-PROCESS; FISH
   SKIN; THICKNESS; MANAGEMENT; DRESSINGS
AB Skin grafting remains a cornerstone technique for repairing full-thickness skin defects. Its success depends on the coordinated optimization of graft survival, healing quality, functional recovery, and aesthetic outcomes. In recent years, a growing array of novel wound dressings, bioactive agents, cell-based therapies, and physical adjunctive modalities have expanded clinical options but simultaneously introduced complexity in balancing benefits against risks. In this review, we construct an evidence-based decision-making framework to guide clinical practice throughout the entire skin grafting process. We first focus on graft immobilization and adherence, critically appraising techniques to optimize graft survival. We then examine strategies for accelerated healing and pain reduction, comparing optimization approaches for donor and recipient sites. Finally, we analyze long-term efficacy and aesthetic outcomes, dissecting the trade-offs among different techniques in functional rehabilitation and scar management. By synthesizing high-quality evidence within this structured framework, this review aims to provide clinicians with a practical, evidence-anchored roadmap for individualized perioperative care.
C1 [Xing, Wang; Jie, Kan] Sichuan Prov Forestry Ctr Hosp, Chengdu, Peoples R China.
   [Huang, Yi; Yao, Jia; Xu, Tielong] Jiangxi Univ Chinese Med, Evidence Based Med Res Ctr Dept, Nanchang, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine
RP Jie, K (通讯作者)，Sichuan Prov Forestry Ctr Hosp, Chengdu, Peoples R China.; Xu, TL (通讯作者)，Jiangxi Univ Chinese Med, Evidence Based Med Res Ctr Dept, Nanchang, Peoples R China.
EM 18508815@qq.com; jxciq_xtl@126.com
FU The 2023 Jiangxi Provincial Education and Teaching Research Reform
   Project for Ordinary Undergraduate Universities [JXJG-23-12-17]
FX The author(s) declared that financial support was received for this work
   and/or its publication. This project was financially supported by 2023
   Jiangxi Provincial Education and Teaching Research Reform Project for
   Ordinary Undergraduate Universities (NO. JXJG-23-12-17). The funder had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUN 23
PY 2026
VL 13
AR 1844508
DI 10.3389/fsurg.2026.1844508
EA JUN 2026
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KQ5SE
UT WOS:001813232800001
PM 42416244
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pandey, G
   Kolipaka, T
   Srinivasarao, DA
   Abraham, N
   Tickoo, V
   Khatri, DK
   Raghuvanshi, RS
   Srivastava, S
AF Pandey, Giriraj
   Kolipaka, Tejaswini
   Srinivasarao, Dadi A.
   Abraham, Noella
   Tickoo, Vidya
   Khatri, Dharmendra Kumar
   Raghuvanshi, Rajeev Singh
   Srivastava, Saurabh
TI Nanotechnology invigorated drug delivery and tissue engineering
   strategies for the management of diabetic foot ulcers: Therapeutic
   approaches and clinical applications
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Diabetic foot ulcers (DFUs); Nanofibers; 3D bioprinting; Tissue
   engineering; Drug repurposing
ID SILVER NANOPARTICLES; WOUND DRESSINGS; GROWTH-FACTORS; INFLAMMATION;
   OXYGEN; BLOOD
AB Diabetic foot ulcers (DFUs) are multifactorial pathological manifestations in diabetes patients that cause foot deformities, ultimately leading to limb amputation. Various therapeutic strategies such as debridement therapy, pressure off-loading, revascularization, low-level laser therapy, hyperbaric oxygen therapy, negative pressure wound therapy, along with wound dressings or anti-microbial therapy are being explored for the management of DFUs. Further, bioactive phytochemicals, growth factors, and repurposed drugs are being employed as alternative strategies. The emergence of nanotechnological interventions in biology and medicine brought a paradigm shift in the clinical management of DFUs. Nanotechnology-based therapeutic interventions help in better presentation of therapeutics at the wound site, thereby augmenting tissue remodelling and regeneration. This review discusses pathophysiology and nanotechnological interventions such as nanoparticles, nanofibers and 3D bioprinting for the management of DFUs. In addition, special emphasis on currently available clinical interventions have been highlighted. Further, hurdles in bench-to-bedside translation, limitations of available animal models, and regulatory perspectives have been emphasized.
C1 [Pandey, Giriraj; Kolipaka, Tejaswini; Srinivasarao, Dadi A.; Abraham, Noella; Srivastava, Saurabh] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Pharmaceut Innovat & Translat Res Lab PITRL, Hyderabad 500037, Telangana, India.
   [Tickoo, Vidya] Yashoda Hosp, Dept Endocrinol, Hyderabad, India.
   [Khatri, Dharmendra Kumar] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmacol, Hyderabad, Telangana, India.
   [Raghuvanshi, Rajeev Singh] Govt India, Minist Hlth & Family Welf, Cent Drugs Stand Control Org CDSCO, Directorate Gen Hlth Serv, New Delhi, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali); National Institute of Pharmaceutical Education & Research,
   Hyderabad; National Institute of Pharmaceutical Education & Research,
   S.A.S. Nagar (Mohali); National Institute of Pharmaceutical Education &
   Research, Hyderabad
RP Srivastava, S (通讯作者)，Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Pharmaceut Innovat & Translat Res Lab PITRL, Hyderabad 500037, Telangana, India.
EM saurabh@niperhyd.ac.in
RI SRINIVASARAO, DADI A/K-7507-2018; Srivastava, Saurabh/GWD-0786-2022;
   KHATRI, DHARMENDRA KUMAR/I-5905-2013
OI SRINIVASARAO, DADI A/0000-0003-1171-0668; Tejaswini,
   K/0000-0002-3895-4753; Srivastava, Saurabh/0000-0003-0723-4363; KHATRI,
   DHARMENDRA KUMAR/0000-0001-7066-7706
FU Department of Pharmaceuticals (DoP) , Ministry of Chemicals and
   Fertilizers, Govt. of India
FX The authors would like to acknowledge the Department of Pharmaceuticals
   (DoP) , Ministry of Chemicals and Fertilizers, Govt. of India to
   "Pharmaceutical Innovation and Translational Research Lab" (PITRL) ,
   Department of Pharmaceutics, National Institute of Pharmaceutical
   Education and Research (NIPER) Hyderabad, INDIA.
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NR 109
TC 17
Z9 18
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD JUN
PY 2024
VL 96
AR 105665
DI 10.1016/j.jddst.2024.105665
EA APR 2024
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D4Z9X
UT WOS:001296294100001
DA 2026-07-24
ER

PT J
AU Flavia, P
   Beatrice, P
   Marco, RC
   Giancarlo, I
   Federico, L
   Diego, R
   Stefano, G
   Daniele, D
AF Flavia, Petrucci
   Beatrice, Perciballi
   Marco, Rivano Capparuccia
   Giancarlo, Iaiani
   Federico, Lo Torto
   Diego, Ribuffo
   Stefano, Gumina
   Daniele, De Meo
TI Compassionate use of cefiderocol in a complex case of extensively
   drug-resistant Acinetobacter baumannii fracture-related
   infection: a comprehensive approach and multidisciplinary management
SO INFECTION
LA English
DT Article
DE Antimicrobial resistance; Fracture related infection; Tibia fracture;
   Acinetobacterbaumannii; Cefiderocol; Multidisciplinary
ID OSTEOMYELITIS; COLISTIN
AB Purpose Fracture-related infections (FRI) pose a difficult management problem, as they require numerous surgical interventions and extended antibiotic treatments, especially when a multidrug-resistant organism is involved, with a paucity of available literature that provides guidance. Results A 42 year-old male presents an open diaphyseal tibia and fibula fracture, complicated by soft tissue necrosis and infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-Ab). Initially treated with a damage control external fixator, the patient underwent multiple surgical procedures, including radical debridement, negative pressure wound therapy, external fixator revisions and reconstructive surgery using a latissimus dorsi free flap. The emergence of colistin resistance in the Acinetobacter baumannii strain led to the compassionate use of cefiderocol, finally achieving clinical cure. Conclusions This case report is one of the firsts that highlights the potential efficacy of cefiderocol in treating challenging bone and joint infections sustained by XDR-Ab. The successful outcome also emphasizes the importance of a comprehensive, multidisciplinary approach in achieving favorable results in complex FRI.
C1 [Flavia, Petrucci] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy.
   [Flavia, Petrucci; Beatrice, Perciballi; Marco, Rivano Capparuccia; Giancarlo, Iaiani; Federico, Lo Torto; Diego, Ribuffo; Daniele, De Meo] Policlin Umberto I Hosp, MITO Infect Traumatol & Orthoped Surg Study Grp, Viale Policlin 155, I-00161 Rome, Italy.
   [Beatrice, Perciballi; Stefano, Gumina; Daniele, De Meo] Sapienza Univ Rome, Dept Anat Forens Med & Musculoskeletal Syst Sci, I-00161 Rome, Italy.
   [Federico, Lo Torto; Diego, Ribuffo] Univ Rome, Orthoped Policlin Umberto I Hosp Sapienza, Dept Gen Surg, Plast Surg Unit,Plast Surg, Viale Policlin 155, I-00161 Rome, Italy.
   [Marco, Rivano Capparuccia; Giancarlo, Iaiani] Policlin Umberto I Univ Hosp, Dept Internal Med Endocrine Metab Sci & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University Hospital
   Sapienza Rome; Sapienza University Rome; Sapienza University Rome;
   Sapienza University Rome; University Hospital Sapienza Rome
RP Flavia, P (通讯作者)，Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy.; Flavia, P (通讯作者)，Policlin Umberto I Hosp, MITO Infect Traumatol & Orthoped Surg Study Grp, Viale Policlin 155, I-00161 Rome, Italy.
EM flavia.petrucci@uniroma1.it
RI ; De Meo, Daniele/AAU-1698-2020
OI PETRUCCI, FLAVIA/0009-0008-1715-9532; De Meo,
   Daniele/0000-0003-1914-5413
FU Universit degli Studi di Roma La Sapienza
FX No Statement Available
CR Alamarat ZI, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.01872-19
   [Anonymous], Antimicrobial Resistance Surveillance inEurope 2022-2020Data
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NR 23
TC 2
Z9 4
U1 3
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD DEC
PY 2024
VL 52
IS 6
BP 2487
EP 2493
DI 10.1007/s15010-024-02294-x
EA MAY 2024
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA O5W9S
UT WOS:001223811600001
PM 38748180
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Domae, K
   Toda, K
   Yoshioka, D
   Miyagawa, S
   Yoshikawa, Y
   Hata, H
   Kainuma, S
   Kawamura, T
   Kawamura, A
   Sawa, Y
AF Domae, Keitaro
   Toda, Koichi
   Yoshioka, Daisuke
   Miyagawa, Shigeru
   Yoshikawa, Yasushi
   Hata, Hiroki
   Kainuma, Satoshi
   Kawamura, Takuji
   Kawamura, Ai
   Sawa, Yoshiki
TI Complex HeartWare left ventricular assist device infection treated with
   pump exchange: clinical alert for the driveline location
SO JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE HVAD; Driveline infection; Pump exchange
AB Infection is a major complication in patients with a left ventricular assist device (LVAD). Once a driveline exit-site infection (DLI) reaches the LVAD component, LVAD exchange may become necessary for radical treatment, although clinical results are not satisfactory. In this report, we describe two cases of LVAD infection successfully treated with pump exchange. During LVAD support, the DLI extended into the pump pocket and the outflow graft despite aggressive surgical debridement and negative pressure wound therapy. These two patients required LVAD exchange for radical treatment, because the estimated waiting period for heart transplantation was at least more than 1 year. The LVAD exchange was performed through median re-sternotomy, and the infected HeartWare ventricular assist device (HVAD) was completely removed under cardiopulmonary bypass. Then, a new LVAD covered with the omentum flap was implanted. These two patients were successfully bridged to heart transplantation after 10 months and 2 years of support without recurrence of infection. These two cases may suggest that the driveline of the HVAD needs to be kept away from the outflow graft to prevent refractory outflow graft infection.
C1 [Domae, Keitaro; Toda, Koichi; Yoshioka, Daisuke; Miyagawa, Shigeru; Yoshikawa, Yasushi; Hata, Hiroki; Kainuma, Satoshi; Kawamura, Takuji; Kawamura, Ai; Sawa, Yoshiki] Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 University of Osaka
RP Sawa, Y (通讯作者)，Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM sawa-p@surg1.med.osaka-u.ac.jp
RI Domae, Keitaro/IUO-6200-2023
OI Domae, Keitaro/0000-0003-3203-323X; Miyagawa,
   Shigeru/0000-0003-0015-6569
CR Abicht T, 2013, ASAIO J, V59, P188, DOI 10.1097/MAT.0b013e318283820d
   John R, 2014, J HEART LUNG TRANSPL, V33, P1066, DOI 10.1016/j.healun.2014.05.010
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   Yuh DD, 2005, ANN THORAC SURG, V80, P1493, DOI 10.1016/j.athoracsur.2004.03.043
NR 7
TC 3
Z9 3
U1 0
U2 2
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1434-7229
EI 1619-0904
J9 J ARTIF ORGANS
JI J. Artif. Organs
PD SEP
PY 2021
VL 24
IS 3
BP 377
EP 381
DI 10.1007/s10047-020-01245-1
EA JAN 2021
PG 5
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA UD4CO
UT WOS:000607492800001
PM 33439371
DA 2026-07-24
ER

PT J
AU Honebrink, R
   Buch, R
   Galpin, P
   Burgess, GH
AF Honebrink, Randy
   Buch, Robert
   Galpin, Peter
   Burgess, George H.
TI First Documented Attack on a Live Human by a Cookiecutter Shark
   (Squaliformes, Dalatiidae: Isistius sp.)
SO PACIFIC SCIENCE
LA English
DT Article
ID BRASILIENSIS; BEHAVIOR; BODY
AB An adult long-distance swimmer attempting to cross the 'Alenuihaha Channel between the Hawaiian islands of Hawai'i and Maui was twice bitten by a cookiecutter shark (Squaliformes, Dalatiidae, Isistius sp.). One of these bites presented as an open, round, concave wound typically observed in cookiecutter shark bites inflicted by members of this genus on a broad spectrum of large biota such as marine mammals, elasmobranchs, and bony fishes. The open wound was debrided, subjected to negative pressure wound therapy, and a split thickness skin graft harvested from the left thigh. Postoperative recovery was complicated by delayed healing of the inferior portion of the graft, and cultures and biopsy were normal skin flora and normal tissue, respectively. At 6 months after the incident, the area appeared to be healing with a stable eschar, and by 9 months the wound was healed. Humans entering pelagic waters at twilight and nighttime hours in areas of Isistius sp. occurrence should do so knowing that cookiecutter sharks are a potential danger, particularly during periods of strong moonlight, in areas of man-made illumination, or in the presence of bioluminescent organisms.
C1 [Honebrink, Randy] Hawaii Div Aquat Resources, Honolulu, HI 96813 USA.
   [Buch, Robert; Burgess, George H.] Univ Florida, Florida Program Shark Res, Florida Museum Nat Hist, Gainesville, FL 32611 USA.
   [Buch, Robert] NOAA, Fisheries Serv, NERO, Gloucester, MA 01930 USA.
   [Galpin, Peter] Maui Mem Med Ctr, Wailuku, HI 96793 USA.
C3 State University System of Florida; University of Florida; National
   Oceanic Atmospheric Admin (NOAA) - USA
RP Honebrink, R (通讯作者)，Hawaii Div Aquat Resources, 1151 Punchbowl St, Honolulu, HI 96813 USA.
EM randy.r.honebrink@hawaii.gov
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NR 26
TC 15
Z9 17
U1 0
U2 27
PU UNIV HAWAII PRESS
PI HONOLULU
PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA
SN 0030-8870
EI 1534-6188
J9 PAC SCI
JI Pac. Sci.
PD JUL
PY 2011
VL 65
IS 3
BP 365
EP 374
DI 10.2984/65.3.365
PG 10
WC Marine & Freshwater Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Marine & Freshwater Biology; Zoology
GA 800OM
UT WOS:000293371300006
OA Bronze
DA 2026-07-24
ER

PT J
AU Kraemer, BA
   Geiger, SE
   Deigni, OA
   Watson, JT
AF Kraemer, Bruce A.
   Geiger, Scott E.
   Deigni, Oliver A.
   Watson, John Tracy
TI Management of Open Lower Extremity Wounds With Concomitant Fracture
   Using a Porcine Urinary Bladder Matrix
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE open leg wounds; extracellular matrix; wound healing; open leg
   fractures; exposed orthopedic hardware
ID OPEN TIBIAL FRACTURES; EXTRACELLULAR-MATRIX; RECONSTRUCTION; SCAFFOLDS;
   CLOSURE; DEGRADATION; COVERAGE; DEFECTS
AB Background. Open wounds of the distal third of the leg and foot with exposed bone, fractures, and hardware are challenging wounds for which to achieve stable coverage. The orthopedic advances in lower extremity fracture management over the last 30 years have allowed a rethinking of the standard operative approach to close these complex wounds. Materials and Methods. The ability of extra cellular matrix (ECM) products to facilitate constructive remodeling of a wound seemed a reasonable approach for treatment, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures. Results. The authors reviewed 9 patients with 11 open fractures of the leg, ankle, or foot treated with a newer ECM wound healing device to total closure. The clinical course and patient management are reviewed. Conclusion. The authors conclude that newer ECM products can provide a reasonable method of management for patients who have wounds with exposed hardware, distal leg wounds, and open foot fractures compared to prolonged negative pressure wound therapy or complex reconstructive operative procedures.
C1 [Kraemer, Bruce A.; Geiger, Scott E.; Deigni, Oliver A.] St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, St Louis, MO USA.
   [Watson, John Tracy] St Louis Univ, Sch Med, Dept Orthoped Surg, St Louis, MO USA.
C3 Saint Louis University; Saint Louis University
RP Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
EM kraemerb@slu.edu
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   YAREMCHUK MJ, 1987, PLAST RECONSTR SURG, V80, P1
NR 16
TC 13
Z9 15
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 387
EP 394
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800004
PM 27861131
DA 2026-07-24
ER

PT J
AU Frieders-Justin, V
   Eckmann, C
   Glaser, B
AF Frieders-Justin, Viktor
   Eckmann, Christian
   Glaser, Benjamin
TI Appropriate surgical management in skin and soft tissue infections
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE negative pressure wound therapy; necrotizing soft tissue infections;
   surgical management of skin and soft tissue infections
ID RESISTANT STAPHYLOCOCCUS-AUREUS; PLACEBO-CONTROLLED TRIAL; RISK;
   ANTIBIOTICS; DEBRIDEMENT; DIAGNOSIS; ABSCESSES; GUIDANCE; ADULTS
AB Purpose of reviewTo present standards and recent technical innovations in the surgical management of skin and soft tissue infections (SSTI).Recent findingsSSTI are a frequent cause of presentation in the acute care setting. They can range from simple and uncomplicated to severe and necrotizing infections. Surgical management plays an important role in the treatment of uncomplicated SSTI. Recent evidence indicates that a subgroup of patients (e.g. immunocompromised patients) profits from a postoperative course of antibiotic treatment of 5-7 days. In diabetic foot infections (DFI), repeated debridement to remove necrotic tissue and control infection can prevent minor and major amputation. In necrotizing soft tissue infections (NSTI), early and aggressive surgical debridement is paramount. Recent advancements have explored skin-sparing techniques in selective cases.SummaryThe management of SSTIs requires a combination of surgical and antimicrobial strategies tailored to the type and severity of the infection. Further clinical research is necessary in order to define more accurately those collectives in severe SSTI who profit from a less aggressive surgical approach.
C1 [Frieders-Justin, Viktor] Med Univ Graz, Sect Surg Res, Graz, Austria.
   [Frieders-Justin, Viktor; Glaser, Benjamin] Klin Donaustadt, Vienna Healthcare Grp, Dept Surg, Vienna, Austria.
   [Eckmann, Christian] Acad Hosp Goettingen Univ, Dept Gen Visceral & Thorac Surg, Klinikum Hanoversch Muenden, Vogelsang 10, D-34346 Hanoversch Muenden, Germany.
C3 Medical University of Graz
RP Eckmann, C (通讯作者)，Acad Hosp Goettingen Univ, Dept Gen Visceral & Thorac Surg, Klinikum Hanoversch Muenden, Vogelsang 10, D-34346 Hanoversch Muenden, Germany.
EM chr.eckmann@gmx.de
RI Glaser, Benjamin/F-8411-2017
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NR 54
TC 4
Z9 6
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2025
VL 38
IS 2
BP 136
EP 142
DI 10.1097/QCO.0000000000001088
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA Y8S8V
UT WOS:001434759500016
PM 39786981
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cheong, DCF
   Chen, CF
   Kuo, WL
   Huang, JJ
AF Cheong, David C. -F.
   Chen, Chia-Fang
   Kuo, Wen-Ling
   Huang, Jung-Ju
TI Profunda Artery Perforator Flap for Autologous Breast Reconstruction: A
   Review of the Evidence and the Linkou Chang Gung Memorial Hospital
   Experience
SO SEMINARS IN PLASTIC SURGERY
LA English
DT Review
DE autologous breast reconstruction; profunda artery perforator flap; PAP
   flap; low-body mass index; patient-reported outcomes; BREAST-Q
ID PAP FLAP; TECHNICAL REFINEMENTS; OUTCOMES
AB This study aimed to summarize and highlight institutional experience on the profunda artery perforator (PAP) flap for autologous breast reconstruction. Contemporary series demonstrate high flap success and patient satisfaction with PAP reconstruction. Key technical evolutions include perforator-targeted skin paddle designs, strategies to augment venous outflow when needed, and standardized donor site management. Comparative studies and systematic reviews suggest reconstructive reliability comparable to other autologous options, while donor site wound morbidity remains the main area for optimization. In the low-body mass index (BMI) Asian cohort, PAP reconstruction achieved high success, and closed-incision negative pressure wound therapy (iNPWT) reduced donor site wound complications. The PAP flap is a versatile alternative when the abdomen is unsuitable, particularly for small-to-moderate volume breast reconstruction. Outcomes are optimized by careful patient selection, perforator mapping, thoughtful flap design, proactive venous outflow planning, and meticulous donor site closure. Stacked/Bilateral PAP strategies and staged fat grafting expand indications when a single flap is unlikely to meet volume requirements.
C1 [Cheong, David C. -F.; Chen, Chia-Fang; Huang, Jung-Ju] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Plast & Reconstruct Surg, Div Reconstruct Microsurg, Taoyuan, Taiwan.
   [Cheong, David C. -F.; Chen, Chia-Fang; Kuo, Wen-Ling; Huang, Jung-Ju] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Cheong, David C. -F.; Chen, Chia-Fang; Kuo, Wen-Ling; Huang, Jung-Ju] Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan, Taiwan.
   [Kuo, Wen-Ling] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Gen Surg, Taoyuan, Taiwan.
   [Kuo, Wen-Ling] Natl Tsing Hua Univ, Sch Med, Hsinchu, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; National Tsing Hua University
RP Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Linkou Med Ctr, Dept Plast & Reconstruct Surg, 5 Fuxing St, Taoyuan City 33305, Taiwan.
EM jungjuhuang@gmail.com
RI Cheong, David/LQK-7335-2024
CR Artz JD, 2022, J RECONSTR MICROSURG, V38, P284, DOI 10.1055/s-0041-1731764
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   Tanaka N, 2024, PRS-GLOB OPEN, V12, DOI 10.1097/GOX.0000000000006129
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   Varnava C, 2024, MICROSURG, V44, DOI 10.1002/micr.31179
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NR 29
TC 0
Z9 0
U1 1
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1535-2188
EI 1536-0067
J9 SEMIN PLAST SURG
JI Semin. Plast. Surg.
PD FEB
PY 2026
VL 40
IS 01
BP 78
EP 82
DI 10.1055/a-2781-5836
EA FEB 2026
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GZ1OW
UT WOS:001677634200001
PM 42037621
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Imaoka, S
   Samura, T
   Yoshioka, D
   Kawamura, M
   Kawamura, T
   Toda, K
   Miyagawa, S
AF Imaoka, Shusuke
   Samura, Takaaki
   Yoshioka, Daisuke
   Kawamura, Masashi
   Kawamura, Takuji
   Toda, Koichi
   Miyagawa, Shigeru
TI Clinical Outcomes of Left Ventricular Assist Device Pump Infection
SO ASAIO JOURNAL
LA English
DT Article
DE left ventricular assist device; pump infection
ID HEART-TRANSPLANT; PARACORPOREAL; STRATEGIES; MANAGEMENT
AB Few studies have focused on the clinical outcomes and risk factors of left ventricular assist device (LVAD) pump infection, and no standard treatment for LVAD pump infection has been established. Therefore, we used a therapeutic flowchart to manage LVAD pump infections. We retrospectively evaluated 220 patients who underwent continuous-flow LVAD implantation between January 2005 and March 2021 at Osaka University, Japan. First, we performed wound debridement, negative-pressure wound therapy, antibiotic treatment, and omental flap transposition. Subsequently, we administered conservative treatment, scheduled implantable LVAD exchange, or emergent removal of the implantable LVAD and exchange for extracorporeal LVAD or percutaneous LVAD (IMPELLA). Pump infections occurred in 32 patients. The survival rates of patients with pump infections during LVAD support were 93%, 74%, and 61% at 180 days, 1 year, and 2 years after LVAD pump infection, respectively. Fifteen patients underwent successful heart transplantation. Bridge-to-bridge surgery, preoperative use of venoarterial extracorporeal membrane oxygenation or percutaneous LVAD, high lactate dehydrogenase levels, and driveline infection were significantly associated with pump infection. Our study reveals that poor preoperative condition and driveline infection were significant risk factors for LVAD pump infection.
C1 [Imaoka, Shusuke; Samura, Takaaki; Yoshioka, Daisuke; Kawamura, Masashi; Kawamura, Takuji; Miyagawa, Shigeru] Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, Osaka, Japan.
   [Toda, Koichi] Dokkyo Med Univ, Saitama Med Ctr, Dept Thorac & Cardiovasc Surg, Saitama, Japan.
   [Yoshioka, Daisuke] Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 University of Osaka; Dokkyo Medical University; University of Osaka
RP Yoshioka, D (通讯作者)，Osaka Univ, Grad Sch Med, Dept Cardiovasc Surg, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM djason55@gmail.com
RI Samura, Takaaki/OVY-9880-2025
OI Samura, Takaaki/0000-0002-3514-4413
CR Bauer TM, 2019, ARTIF ORGANS, V43, P448, DOI 10.1111/aor.13378
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   Kinugawa K, 2020, GEN THORAC CARDIOVAS, V68, P102, DOI 10.1007/s11748-019-01227-y
   Koval C, 2018, CURR OPIN ORGAN TRAN, V23, P400, DOI 10.1097/MOT.0000000000000548
   Kusne S, 2017, J HEART LUNG TRANSPL, V36, P1137, DOI 10.1016/j.healun.2017.06.007
   Nakajima S, 2021, J CARDIOL, V77, P408, DOI 10.1016/j.jjcc.2020.11.003
   Nienaber JJC, 2013, CLIN INFECT DIS, V57, P1438, DOI 10.1093/cid/cit536
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   Still S, 2020, J CARDIAC SURG, V35, P2825, DOI 10.1111/jocs.14794
   Toda K, 2012, ANN THORAC SURG, V94, P1387, DOI 10.1016/j.athoracsur.2012.03.021
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NR 17
TC 5
Z9 6
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD DEC
PY 2023
VL 69
IS 12
BP 1056
EP 1064
DI 10.1097/MAT.0000000000002031
PG 9
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA EY4W1
UT WOS:001142492900006
PM 37549664
DA 2026-07-24
ER

PT J
AU Bui, RD
   Lam, K
   Panchbhavi, VK
AF Bui, Roger D.
   Lam, Kenrick
   Panchbhavi, Vinod K.
TI Efficacy of a Urinary Bladder Matrix for Treating Wound Dehiscence With
   Hardware Exposure in a Patient With Rheumatoid Arthritis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE hardware exposure; infection; rheumatoid arthritis; urinary bladder
   matrix; wound dehiscence
ID INFECTIONS; SURGERY; THERAPY; FOOT; RISK
AB Objective. This case report explores an effective treatment modality in a medically complicated patient, with considerable wound dehiscence refractory to treatment with negative pressure wound therapy (NPWT). Case Report. A 35-year-old woman with a past medical history of hypothyroidism, osteoporosis, and rheumatoid arthritis treated with tumor necrosis factor (TNF) alpha inhibitors and disease-modifying antirheumatic drugs presented to the clinic following right great toe arthrodesis, metatarsal neck osteotomies, extensor tendon lengthening, and capsulotomy of the second, third, fourth, and fifth toes 2 weeks prior, with wound dehiscence of the right great toe and subsequent exposure of surgical hardware, complicated by infection. At the 2-week postop, a urinary bladder matrix was placed on the wound following failed NPWT, which was in place for io days. At the 3-month follow-up, the wound was closed and without any drainage. Patient reported a significant reduction in pain (visual analogue scale: 3) with adherence to weight-bearing restrictions. Conclusions. Wound healing was accomplished without removal of the exposed deep hardware in a patient with comorbidities and post-surgical wound dehiscence.
C1 [Bui, Roger D.; Lam, Kenrick; Panchbhavi, Vinod K.] Univ Texas Med Branch, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch Galveston
RP Bui, RD (通讯作者)，Univ Texas Med Branch, Sch Med, 3O1 Univ Blvd, Galveston, TX 77555 USA.
EM rdbui@utmb.edu
RI Panchbhavi, Vinod/AAN-1355-2021
CR Alvarez OM, 2017, WOUNDS, V29, P140
   Berthold E, 2013, ACTA ORTHOP, V84, P495, DOI 10.3109/17453674.2013.842431
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   Ishie S, 2015, MOD RHEUMATOL, V25, P367, DOI 10.3109/14397595.2014.966975
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   Kimmel Howard, 2010, J Am Col Certif Wound Spec, V2, P55, DOI 10.1016/j.jcws.2010.11.002
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   Listing J, 2005, ARTHRITIS RHEUM-US, V52, P3403, DOI 10.1002/art.21386
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   Mendonca DA, 2005, FOOT ANKLE INT, V26, P761, DOI 10.1177/107110070502600915
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   Viol A, 2009, PLAST RECONSTR SURG, V123, P1256, DOI 10.1097/PRS.0b013e31819f2b5e
NR 16
TC 2
Z9 3
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2020
VL 32
IS 4
BP E27
EP E30
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NF1CR
UT WOS:000563040100001
PM 32335519
DA 2026-07-24
ER

PT J
AU Shatnawi, NJ
   Al-Zoubi, NA
   Al-Bakkar, LA
   Gharaibeh, LM
   Hamouri, S
AF Shatnawi, Nawaf J.
   Al-Zoubi, Nabil A.
   Al-Bakkar, Lujain A.
   Gharaibeh, Laith M.
   Hamouri, Shadi
TI Nonhealing Leg Ulcer as the Presentation of Sarcoidosis: A Case Report
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE pyoderma gangrenosum; ulcerative sarcoidosis; leg ulcer
ID TUNING FORK; RELIABILITY; NEUROPATHY; DEVICE
AB Chronic leg ulcers (CLUs) are common, with increasing prevalence in the elderly population. Circulatory dysfunctions are responsible for 90% to 95% of all causes, while 5% to 10% of CLUs are associated with underlying chronic systemic disorders. Sarcoidosis is a complex multisystemic disease characterized by noncaseating granulomas affecting mainly the pulmonary system, with cutaneous manifestation in 25% to 30% of cases. However, ulcerative sarcoidosis (US) is a rare form of cutaneous sarcoidosis. Pyoderma gangrenosum (PG) is an uncommon, chronic inflammatory noninfectious skin disease affecting different body parts. The ulcerative form of PG is rarely reported in association with sarcoidosis. We aim to report a 44-year-old female patient with a history of hypertension and varicose veins, presenting with a CLU for more than 18 months. Ulcer tissue biopsy showed noncaseating granuloma with abscess formation suggestive of sarcoidosis; however, PG could not be ruled out. Mediastinal lymph node biopsy was consistent with sarcoidosis. The leg ulcer had complete healing within 4 months by local wound management, negative pressure wound therapy, and split-thickness skin grafting without immunosuppressive treatment to achieve wound healing.
C1 [Shatnawi, Nawaf J.; Al-Zoubi, Nabil A.; Al-Bakkar, Lujain A.; Gharaibeh, Laith M.; Hamouri, Shadi] Jordan Univ Sci & Technol, Irbid, Jordan.
C3 Jordan University of Science & Technology
RP Shatnawi, NJ (通讯作者)，Jordan Univ Sci & Technol, Dept Gen Surg & Urol, POB 3030, Irbid 22110, Jordan.
EM nshatnawi@yahoo.com
RI ; Hamouri, Shadi/AAM-9465-2021
OI Garibeh, Laith/0000-0002-4202-695X; Bakkar, Lujain/0000-0001-8093-0678;
   Hamouri, Shadi/0000-0002-1764-9514
CR Abbade LPF, 2020, AN BRAS DERMATOL, V95, P1, DOI 10.1016/j.abd.2020.06.002
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   Maverakis E, 2018, JAMA DERMATOL, V154, P461, DOI 10.1001/jamadermatol.2017.5980
   Mendiratta N., 2018, Open J Clin Med Case Rep, V4, P1471
   Noiles K, 2013, J CUTAN MED SURG, V17, P377, DOI 10.2310/7750.2013.13035
   Ormerod AD, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h2958
   Powell E, 2017, CUTIS, V100, P312
   POWELL FC, 1984, ARCH DERMATOL, V120, P959, DOI 10.1001/archderm.120.7.959
   Semenic D, 2020, WOUNDS, V32, pE1
   Ungprasert Patompong, 2019, Mayo Clin Proc Innov Qual Outcomes, V3, P358, DOI [10.1016/j.mayocpiqo.2019.04.006, 10.1016/j.mayocpiqo.2019.04.006]
   Vinayak AgaleShubhangi., 2013, Ulcers, V2013, P9, DOI DOI 10.1155/2013/413604
   Wollina U, 2016, INT J LOW EXTR WOUND, V15, P263, DOI 10.1177/1534734616652553
NR 17
TC 2
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2023
VL 22
IS 4
BP 742
EP 747
AR 15347346211037850
DI 10.1177/15347346211037850
EA AUG 2021
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EY2S2
UT WOS:000683973400001
PM 34374584
DA 2026-07-24
ER

PT J
AU Montori, G
   Di Giovanni, G
   Mzoughi, Z
   Angot, C
   Al Samman, S
   Solaini, L
   Cheynel, N
AF Montori, Giulia
   Di Giovanni, Giacomo
   Mzoughi, Zeineb
   Angot, Cedric
   Al Samman, Sophie
   Solaini, Leonardo
   Cheynel, Nicolas
TI Pneumoretroperitoneum and Pneumomediastinum Revealing a Left Colon
   Perforation
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Pneumomediastinum; Retroperitoneum; Colonic; Perforation
ID SIGMOID DIVERTICULUM PERFORATION; SOFT-TISSUE INFECTIONS
AB Left colon perforation usually occurs in complicated diverticulitis or cancer. The most frequent signs are intraperitoneal abscess or peritonitis. In cases of retroperitoneal colonic perforation, diagnosis may be difficult. A 59-year-old woman presented with left thigh pain and with abdominal discomfort associated with mild dyspnea. Computed tomography scan showed air bubbles and purulent collection in the retroperitoneum, with subcutaneous emphysema extending from the left thigh to the neck. Computed tomography scan also revealed portal vein gas and thrombosis with multiple liver abscesses. An emergency laparotomy revealed a perforation of the proximal left colon. No masses were found. A left colectomy was performed. The retroperitoneum was drained and washed extensively. A negative pressure wound therapy was applied. A second-look laparotomy was performed 48 hours later. The retroperitoneum was drained and an end colostomy was performed. Intensive Care Unit postoperative stay was 9 days, and the patient was discharged on the 32nd postoperative day. Pneumoretroperitoneum and pneumomediastinum are rare signs of colonic retroperitoneal perforation. The diagnosis may be delayed, especially in the absence of peritoneal irritation. Clinical, laboratory, and especially radiologic parameters might be useful. Surgical treatment must be prompt to improve prognosis.
C1 [Montori, Giulia; Di Giovanni, Giacomo; Mzoughi, Zeineb; Angot, Cedric; Al Samman, Sophie; Cheynel, Nicolas] Ctr Hosp Univ Bocage, Dept Gen & Emergency Surg, Dijon, France.
   [Solaini, Leonardo] Univ Brescia, Dept Clin & Surg Sci, Surg Clin, I-25128 Brescia, Italy.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; University of Brescia
RP Solaini, L (通讯作者)，Univ Brescia, Dept Clin & Surg Sci, Surg Clin, I-25128 Brescia, Italy.
EM leonardosolaini@gmail.com
RI ; Montori, Giulia/ABF-9661-2020; /AAQ-2317-2021
OI Solaini, Leonardo/0000-0002-5031-9285; Montori,
   Giulia/0000-0002-7649-2174; 
CR Biondo S, 2002, AM J SURG, V183, P256, DOI 10.1016/S0002-9610(02)00780-8
   Choi PW, 2011, J KOREAN SURG SOC, V80, pS17, DOI 10.4174/jkss.2011.80.Suppl1.S17
   Elliott DC, 1996, ANN SURG, V224, P672, DOI 10.1097/00000658-199611000-00011
   Ioannidis O, 2011, ANN ITAL CHIR, V82, P217
   Mailleux P, 2012, JBR-BTR, V95, P13
   MOGAN GR, 1980, GASTROENTEROLOGY, V79, P559
   Rees JR, 2009, BMJ CASE REP, V2009
   Sivarajah V, 2013, INT J SURG CASE REP, V4, P531, DOI 10.1016/j.ijscr.2013.01.031
   Urschel JD, 1999, POSTGRAD MED J, V75, P645, DOI 10.1136/pgmj.75.889.645
   Yasar NF, 2011, ULUS TRAVMA ACIL CER, V17, P93, DOI 10.5505/tjtes.2011.69783
NR 10
TC 7
Z9 9
U1 0
U2 1
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD JUN
PY 2015
VL 100
IS 6
BP 984
EP 988
DI 10.9738/INTSURG-D-14-00201.1
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CS3OO
UT WOS:000361984200005
PM 26414818
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Brown, DJ
   Lu, KJG
   Chang, K
   Levin, J
   Schulz, JT
   Goverman, J
AF Brown, Darnell J.
   Lu, Kuo Jung G.
   Chang, Kristina
   Levin, Jennifer
   Schulz, John T., III
   Goverman, Jeremy
TI A rare case of severe third degree friction burns and large
   Morel-Lavallee lesion of the abdominal wall
SO BURNS & TRAUMA
LA English
DT Article
DE Friction burns; Blunt trauma friction burns; Internal degloving
   injuries; Morel-Lavallee lesion; Traumatic pseudocyst
ID MANAGEMENT; EXPERIENCE
AB Background: Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. MLL is often overlooked in the setting of poly-trauma; therefore, clinicians must maintain a high degree of suspicion and be familiar with the management of such injuries, especially in obese poly-trauma patients.
   Case presentation: We present a 30-year-old female pedestrian struck by a motor vehicle who sustained multiple long bone fractures, a mesenteric hematoma, and full-thickness abdominal skin friction burn which masked a significant underlying abdominal MLL. The internal degloving caused significant devascularization of the overlying soft tissue and skin which required surgical drainage of hematoma, abdominal wall reconstruction with tangential excision, allografting, negative pressure wound therapy, and ultimately autografting.
   Conclusion: MLL is a rare, often overlooked, internal degloving injury. Surgeons must maintain a high index of suspicion when dealing with third degree friction burns as they may mask underlying injuries such as MLL, and a delay in diagnosis can lead to increased morbidity.
C1 [Brown, Darnell J.; Lu, Kuo Jung G.; Chang, Kristina; Levin, Jennifer; Schulz, John T., III; Goverman, Jeremy] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Brown, DJ (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
EM DJBrown85@MGH.Harvard.edu
RI Goverman, Jeremy/AAZ-6769-2020
CR Beckmann NM, 2016, EMERG RADIOL, V23, P615, DOI 10.1007/s10140-016-1430-1
   Dallaudiere B, 2016, DIAGN INTERV IMAG, V97, P257, DOI 10.1016/j.diii.2015.06.015
   Elson RA, 1993, FRACTURES ACETABULUM, P417
   Grob M, 2003, BURNS, V29, P714, DOI 10.1016/S0305-4179(03)00072-X
   Han T, 2005, BURNS, V31, P906, DOI 10.1016/j.burns.2005.04.023
   Lamyman MJ, 2009, J PLAST RECONSTR AES, V62, pE394, DOI 10.1016/j.bjps.2008.01.027
   Luria S, 2006, J ORTHOP TRAUMA, V20, P435, DOI 10.1097/00005131-200607000-00013
   McKenzie GA, 2016, SKELETAL RADIOL, V45, P1053, DOI 10.1007/s00256-016-2374-y
   Nickerson TP, 2014, J TRAUMA ACUTE CARE, V76, P493, DOI 10.1097/TA.0000000000000111
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   Shunsuke T, 2014, CASE REPORTS ORTHOPE
   STERLING A, 1977, J TRAUMA, V17, P392, DOI 10.1097/00005373-197705000-00012
   Tseng S, 2006, J BONE JOINT SURG AM, V88A, P92, DOI 10.2106/JBJS.E.00021
   Yilmaz A, 2013, Prague Med Rep, V114, P123
NR 14
TC 5
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2321-3868
EI 2321-3876
J9 BURNS TRAUMA
JI Burns Trauma
PD MAR 6
PY 2018
VL 6
AR 6
DI 10.1186/s41038-018-0108-1
PG 4
WC Emergency Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Dermatology; Surgery
GA FY3FU
UT WOS:000426704900001
PM 29556506
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Eniko, S
   Nándor, L
   Annamária, B
   Erika, S
   László, S
   János, A
   Gábor, C
AF Eniko, Szucs
   Nandor, Lukacs
   Annamaria, Budai
   Erika, Seres
   Laszlo, Sikorszki
   Janos, Argyelin
   Gabor, Cserni
TI Actinomycosis mimicking urachal cancer
SO ORVOSI HETILAP
LA English
DT Article
DE actinomycosis; urachus; neoplasm; differential diagnosis
AB Tumours and other diseases of the urachus are rare. A 67-year-old male presented with a history of recurrent urinary tract infection and ciprofloxacin therapy. Cystoscopy suggested secondary involvement of the bullous upper bladder wall. The subsequent CT-based diagnosis was of a tumour infiltrating the lower median abdominal wall, the urinary bladder and bowels. Bowel obstruction developed and this led to partial resection of the involved organs along with a Hartmann's procedure. Histology revealed no neoplastic conditions, but proved abdominal actinomycosis of probable urachal origin based on the location of the tumour-like lesion and umbilical discharge among the symptoms. Urachal remnants were not identified in the perivesical tissues involved by the microabscess forming inflammation. Amoxicillin therapy was initiated. After a temporary urine leakage from the bladder, the patient became symptomless and was emitted from hospital. After 13 days, he was readmitted because of abdominal wound disruption, which was treated with negative-pressure wound therapy before the abdomen could be closed. At the time of reporting, he is still on amoxicillin, and has become symptomless again. Actinomycosis should be considered in the differential diagnosis of mass lesions of the urachal region.
C1 [Eniko, Szucs] Bacs Kiskun Megyei Oktatokorhaz, Kozponti Radiol Osztaly, Kecskemet, Hungary.
   [Nandor, Lukacs] Bacs Kiskun Megyei Oktatokorhaz, Urol Osztaly, Kecskemet, Hungary.
   [Annamaria, Budai] Bacs Kiskun Megyei Oktatokorhaz, Gasztroenterol Osztaly, Kecskemet, Hungary.
   [Erika, Seres] Bacs Kiskun Megyei Oktatokorhaz, Kozponti Klin Lab, Kecskemet, Hungary.
   [Laszlo, Sikorszki] Bacs Kiskun Megyei Oktatokorhaz, Altalanos Sebeszeti Osztaly, Kecskemet, Hungary.
   [Janos, Argyelin; Gabor, Cserni] Bacs Kiskun Megyei Oktatokorhaz, Patol Osztaly, Kecskemet, Hungary.
   [Gabor, Cserni] Szegedi Tud Egyet, Szent Gyorgyi Albert Klin KOzpont, Altalanos Orvostud Kar, Patol Int, Szeged, Hungary.
C3 Szeged University
RP Gábor, C (通讯作者)，Nyiri Ut 38, H-6000 Kecskemet, Hungary.
EM cserni@freemail.hu
RI Cserni, Gabor/JCN-6784-2023
CR Biró A, 2021, ORVOSI HETILAP, V162, P116, DOI 10.1556/650.2021.31975
   Chaitra V, 2011, INDIAN J UROL, V27, P545, DOI 10.4103/0970-1591.91450
   Cserni G., 2006, LEGE ARTIS MED, V16, P654
   Hasko L, 1977, Orv Hetil, V118, P1415
   Lim KT, 2010, KOREAN J UROL, V51, P438, DOI 10.4111/kju.2010.51.6.438
   Maddah Ghodratolah, 2013, Nephrourol Mon, V5, P997, DOI 10.5812/numonthly.10933
   Molnar Tamas, 1999, Orvosi Hetilap, V140, P2453
   Reis H, 2018, INT J CANCER, V143, P1764, DOI 10.1002/ijc.31547
   Sharma S, 2021, StatPearls
   Sithika T Ayeesha, 2017, Int J Appl Basic Med Res, V7, P77, DOI [10.4103/2229-516x.198538, 10.4103/2229-516X.198538]
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   Yeung Y, 2001, Urology, V58, P462, DOI 10.1016/S0090-4295(01)01189-X
NR 12
TC 1
Z9 1
U1 0
U2 1
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD JAN
PY 2022
VL 163
IS 4
BP 157
EP 160
DI 10.1556/650.2022.32325
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YN1TA
UT WOS:000747046500005
PM 35066489
OA Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Hutan, M
   Bartko, C
   Majesky, I
   Prochotsky, A
   Sekac, J
   Skultety, J
AF Hutan, Martin
   Bartko, Christian
   Majesky, Ivan
   Prochotsky, Augustin
   Sekac, Jaroslav
   Skultety, Jan
TI Reconstruction option of abdominal wounds with large tissue defects
SO BMC SURGERY
LA English
DT Article
DE NPWT; Split skin grafting; Abdominal wall defect
ID INTRAPERITONEAL COMPOSITE MESH; VACUUM PACK TECHNIQUE; VASCULAR
   SURGICAL-PATIENTS; WALL DEFECTS; HERNIA REPAIR; INCISIONAL
   HERNIORRHAPHY; 7-YEAR EXPERIENCE; TEMPORARY CLOSURE; INGUINAL-HERNIA;
   INFECTION RISK
AB Background: Abdominal wall defects result from trauma, abdominal wall tumors, necrotizing infections or complications of previous abdominal surgeries. Apart from cosmetics, abdominal wall defects have strong negative functional impact on the patients.
   Many different techniques exist for abdominal wall repair. Most problematic and troublesome are defects, where major part of abdominal wall had to be resected and tissue for transfer or reconstruction is absent.
   Case presentation: Authors of the article present operative technique, in which reconstruction of abdominal wall was managed by composite polypropylene mesh with absorbable collagen film, creation of granulation tissue with use of NPWT (negative pressure wound therapy), and subsequent split skin grafting. Three patients with massive abdominal wall defect were successfully managed and abdominal wall reconstruction was performed by mentioned technique. Functional and cosmetic effect is acceptable and patients have good postoperative quality of life.
   Conclusions: Patients with giant abdominal defects can benefit from described technique. It serves as the only option, with which abdominal wall is fully reconstructed without need for the secondary intervention.
C1 [Hutan, Martin; Bartko, Christian; Majesky, Ivan; Prochotsky, Augustin; Sekac, Jaroslav; Skultety, Jan] Comenius Univ, Fac Med, Surg Clin 2, Univ Hosp Bratislava,Hosp st Cyril & Methodius, Bratislava 85107, Slovakia.
C3 Comenius University Bratislava; Slovak Medical University Bratislava
RP Hutan, M (通讯作者)，Comenius Univ, Fac Med, Surg Clin 2, Univ Hosp Bratislava,Hosp st Cyril & Methodius, Antolska 11, Bratislava 85107, Slovakia.
EM matohuto@yahoo.com
OI Bartko, Christian/0009-0002-5274-0230
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NR 30
TC 11
Z9 13
U1 0
U2 23
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD AUG 8
PY 2014
VL 14
AR 50
DI 10.1186/1471-2482-14-50
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN5QQ
UT WOS:000340646800001
PM 25103782
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Elwood, ET
   Bolitho, DG
AF Elwood, ET
   Bolitho, DG
TI Negative-pressure dressings in the treatment of hidradenitis suppurativa
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Negative-pressure dressings have been used in the treatment of a variety of open wounds, and as a bolster for skin grafts. The benefits of these dressings include increased oxygen tension in the wound, decreased bacterial counts, increased granulation formation, and the prevention of shear force on wounds. Also, by virtue of the diminished need for daily dressing changes, there are the additional advantages of enhancing patient comfort, decreasing nursing work, and diminished cost of wound care. Hidradenitis suppurativa (HS) is a chronic infection of the apocrine sweat glands. Treatment options range from oral isotretinoin to radical excision. Wound closure may be achieved by secondary intention, skin grafting, or flap closure, Complications may still arise and include disease progression and squamous cell carcinoma. Radical excision yields the best results in terms of disease eradication. The authors describe using the negative-pressure dressing in two cases of bilateral axillary HS to secure skin grafts firmly to the wound bed after radical excision of all involved tissues. Patient comfort and acceptance was high, and skin graft take was excellent. The dressings themselves are simple to apply and are highly effective.
C1 Emory Univ, Sch Med, Dept Surg, Div Plast Surg, Atlanta, GA 30322 USA.
C3 Emory University
RP Elwood, ET (通讯作者)，1365 Clifton R NE,Bldg B,Suite 2100, Atlanta, GA 30322 USA.
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NR 15
TC 34
Z9 62
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JAN
PY 2001
VL 46
IS 1
BP 49
EP 51
DI 10.1097/00000637-200101000-00010
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 391PR
UT WOS:000166364800010
PM 11192034
DA 2026-07-24
ER

PT J
AU Jiang, T
   Li, QY
   Qiu, JM
   Chen, J
   Du, S
   Xu, X
   Wu, ZH
   Yang, XF
   Chen, ZB
   Chen, TK
AF Jiang, Tao
   Li, Qianyun
   Qiu, Jinmei
   Chen, Jing
   Du, Shuang
   Xu, Xiang
   Wu, Zihan
   Yang, Xiaofan
   Chen, Zhenbing
   Chen, Tongkai
TI Nanobiotechnology: Applications in Chronic Wound Healing
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Article
DE nanobiotechnology; chronic wound healing; scaffold systems;
   cell-carrying systems; stimuli-responsive systems
ID MESENCHYMAL STEM-CELLS; SILVER NANOPARTICLES SYNTHESIS; ANTIBACTERIAL
   ACTIVITY; ANTIMICROBIAL ACTIVITY; RESISTANT BACTERIA; PEO NANOFIBERS;
   IN-VITRO; HYDROGEL; DELIVERY; CHITOSAN
AB Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology - which comprises a diverse array of technologies derived from engineering, chemistry, and biology - is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.
C1 [Jiang, Tao; Li, Qianyun; Chen, Jing; Xu, Xiang; Wu, Zihan; Yang, Xiaofan; Chen, Zhenbing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan, Peoples R China.
   [Qiu, Jinmei; Du, Shuang; Chen, Tongkai] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Peoples R China.
   [Chen, Zhenbing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.
   [Chen, Tongkai] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, 12 Jichang Rd, Guangzhou 510405, Peoples R China.
C3 Huazhong University of Science & Technology; Guangzhou University of
   Chinese Medicine; Huazhong University of Science & Technology; Guangzhou
   University of Chinese Medicine
RP Chen, ZB (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.; Chen, TK (通讯作者)，Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, 12 Jichang Rd, Guangzhou 510405, Peoples R China.
EM zbchen@hust.edu.cn; chentongkai@gzucm.edu.cn
RI Chen, Tongkai/GYJ-1891-2022; Xu, Xiang/QAZ-0344-2026; Yang,
   Xiaofan/P-9140-2019
OI Chen, Tongkai/0000-0002-4347-0155; Chen, Zhenbing/0000-0003-2828-866X;
   chen, jing/0009-0004-4504-7782; Chen, Zhenbing/0009-0005-7882-7205; 
FU National Natural Science Foundation of China [81974289, 81772094]; Key
   Research and Development Program of Hubei Province [2020BCB031];
   Guangdong Basic and Applied Basic Research Foundation [2019B1515120043];
   international cooperation research project of Shenzhen
   [GJHZ20190822091601691]; Key Project of Basic Research of Shenzhen
   [JCYJ20200109113603854]
FX The authors acknowledge the support from the National Natural Science
   Foundation of China (81974289, 81772094) , the Key Research and
   Development Program of Hubei Province (grant number 2020BCB031) , the
   Guangdong Basic and Applied Basic Research Foundation (2019B1515120043)
   , the international cooperation research project of Shenzhen, the
   international cooperation research project of Shenzhen
   (GJHZ20190822091601691) , and the Key Project of Basic Research of
   Shenzhen (JCYJ20200109113603854) .
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NR 222
TC 47
Z9 53
U1 1
U2 84
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-9114
EI 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2022
VL 17
BP 3125
EP 3145
DI 10.2147/IJN.S372211
PG 21
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA 3G6LX
UT WOS:000831464700001
PM 35898438
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bischoff, A
   Stone, R
   Quisno, A
   Figas, S
   Pierre, A
AF Bischoff, Alex
   Stone, Ryan
   Quisno, Amanda
   Figas, Samantha
   Pierre, Andrew
TI Peroneus Brevis Muscle Flap for a 20-year- old Neuroischemic Diabetic
   Ulcer Induced by Traumatic Injury: A Case Report Detailing the Efficacy
   of Advanced Combined Treatment Modalities for Chronic Wound Closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE orthoplastics; peroneus brevis; muscle flap; pedicle flap; chronic
   osteomyelitis; chronic wound
ID EXTERNAL FIXATION; RECONSTRUCTIVE SURGERY; EXPERIENCES; THERAPY
AB Introduction. Peroneus brevis flaps provide a viable option to achieve soft tissue coverage in hard-to-heal lower extremity wounds, specifically those to the lateral ankle and hindfoot. Case Report. The authors present a unique case of a patient with a 20-year-old wound dehiscence complicated by osteomyelitis. The wound was a complication from a lateral extensile incision utilized during prior calcaneal open reduction and internal fixation. Due to many factors, including multiple comorbidities, the patient could not obtain complete healing despite IV antibiotics, vascular optimization, local wound care, surgical debridement, and grafting. Wound closure was ultimately achieved with a PB muscle flap. Adjunctive therapies also utilized included multilevel ring external fixation, negative pressure wound therapy, and hyperbaric oxygen therapy. On follow-up 32 months after the procedure, the patient continued to be wound free and satisfied with the results. Conclusions. This case report demonstrates the utility of PB muscle flaps for hard-to-heal lower extremity wounds in patients with comorbidities.
C1 [Bischoff, Alex; Stone, Ryan; Quisno, Amanda] Grant Med Ctr, Foot & Ankle Surg Residency, Columbus, OH USA.
   [Quisno, Amanda] Foot & Ankle Specialists Cent Ohio, Gahanna, OH USA.
   [Figas, Samantha] Cleveland Clin, Akron Gen Phys Med Grp, Akron, OH USA.
   [Pierre, Andrew] Nashville Gen Hosp, Dept Orthopaed, Nashville, TN USA.
   [Bischoff, Alex] Grant Med Ctr, Med Educ Dept, Foot & Ankle Residency Program, 111 South Grant Ave, Columbus, OH 43215 USA.
C3 Cleveland Clinic Foundation
RP Bischoff, A (通讯作者)，Grant Med Ctr, Med Educ Dept, Foot & Ankle Residency Program, 111 South Grant Ave, Columbus, OH 43215 USA.
EM Alex.Bischoff@ohiohealth.com
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NR 27
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E42
EP E46
DI 10.25270/wnds/22008
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500011
PM 36749998
DA 2026-07-24
ER

PT J
AU Fernandez, L
   Schar, A
   Matthews, M
   Kim, PJ
   Thompson, C
   Williams, N
   Stutsman, M
AF Fernandez, Luis
   Schar, Adam
   Matthews, Marc
   Kim, Paul J.
   Thompson, Christopher
   Williams, Natalie
   Stutsman, Mandy
TI Synthetic Hybrid-Scale Fiber Matrix in the Trauma and Acute Care
   Surgical Practice
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE synthetic hybrid-scale fiber matrix; negative pressure wound therapy;
   split-thickness skin graft; acute wound
ID OPEN FRACTURES; MANAGEMENT; CALCIPHYLAXIS; CLOSURE
AB Complex cutaneous wounds resulting from disease and trauma can be difficult to heal and may require advanced treatment options. Split-thickness skin grafts (STSGs) and other biologic allogeneic and xenogeneic skin substitutes are limited in their ability to manage these lesions, and STSGs may also be limited in availability. A synthetic hybrid-scale fiber matrix, engineered with an architecture similar to native extracellular matrix, has been shown to have excellent durability and does not carry the risks of disease transmission or inflammatory response associated with biologic materials; it may offer a new option for managing these complex wounds. In this preliminary study, the synthetic matrix was used to treat 3 patients with difficult-to-treat wounds, including lesions associated with calciphylaxis, enteroatmospheric abdominal fistula, and necrotizing fasciitis of the hand with exposed tendon. Treatment with the synthetic matrix resulted in significant reepithelialization and wound healing. The successful results suggest that the synthetic matrix enables healing of complex cutaneous wounds and may be a reasonable alternative to STSG, even in particularly challenging cases.
C1 [Fernandez, Luis; Schar, Adam; Williams, Natalie; Stutsman, Mandy] Univ Texas Tyler, Hlth Sci Ctr, Tyler, TX 75799 USA.
   [Matthews, Marc] Univ Arizona, Coll Med, Tucson, AZ USA.
   [Kim, Paul J.] UT Southwestern, Dallas, TX USA.
   [Thompson, Christopher] UT Hlth East Texas, Tyler, TX USA.
C3 University of Texas System; University of Texas-Health Sciences Center
   at Tyler (UTHSCT); University of Texas at Tyler; University of Arizona;
   University of Texas System; University of Texas Southwestern Medical
   Center
RP Fernandez, L (通讯作者)，Univ Texas Tyler, Hlth Sci Ctr, Dept Surg, Tyler, TX 75799 USA.
EM thebigkahuna115@gmail.com
RI ; FERNANDEZ, LUIS/O-7657-2019
OI , Paul/0000-0002-6186-6890; 
CR Aljasir A, 2018, GMS INTERDISCIP PLAS, V7, DOI 10.3205/iprs000123
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NR 31
TC 18
Z9 20
U1 1
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2021
VL 33
IS 9
BP 237
EP 244
DI 10.25270/wnds/2021.237244
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WT5BS
UT WOS:000715879600004
PM 34734842
DA 2026-07-24
ER

PT J
AU van Grinsven, V
   Schouppe, E
   Tollens, T
AF van Grinsven, Vincent
   Schouppe, Ernest
   Tollens, Tim
TI Use of Negative Pressure Wound Therapy to Successfully Treat
   Postoperative Pyoderma Gangrenosum Following Laparoscopic Surgery: A
   Case Report
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
AB Introduction. PG is a rare neutrophilic skin disorder with a variable clinical presentation, and diagnosis is often delayed. PPG typically presents as a necrotic ulcerative lesion with surrounding erythema and is often mistaken for a surgical site infection. Delayed diagnosis can lead to extensive morbidity and a prolonged healing time. Case Report. A 75-year-old male presented to the emergency department 2 weeks following laparoscopic appendectomy for acute appendicitis. He had fever and a suspected surgical site infection. Antibiotic treatment was initiated, and debridement was performed. Eventually, the diagnosis of PPG was made. Immunosuppressive therapy combined with NPWT was initiated. Complete wound healing was achieved 2 months after admission. Conclusions. Surgeons should have a high index of suspicion of underlying skin disorders when presumed postoperative wound infections do not respond to aggressive antibiotic and surgical treatment. Early multidisciplinary consultation should be considered. In the case of PPG, the authors of the present report advise early initiation of systemic immunosuppressive therapy combined with atraumatic wound care. NPWT should be considered as appropriate. Surgical debridement may be indicated in the setting of extensive necrosis or uncontrollable superinfection.
C1 [van Grinsven, Vincent] Univ Hosp Leuven, Dept Gen Surg, Leuven, Belgium.
   [Schouppe, Ernest] Univ Hosp Leuven, Dept Plast Surg, Leuven, Belgium.
   [Tollens, Tim] Imelda Hosp, Dept Gen & Abdominal Surg, Bonheiden, Belgium.
   [van Grinsven, Vincent] Herestr 49, B-3000 Vlaams Brabant, Belgium.
C3 KU Leuven; University Hospital Leuven; KU Leuven; University Hospital
   Leuven; Imeldaziekenhuis
RP van Grinsven, V (通讯作者)，Herestr 49, B-3000 Vlaams Brabant, Belgium.
EM vincent.vangrinsven@student.kuleuven.be
OI van Grinsven, Vincent/0000-0002-5513-6971
CR Alavi A, 2017, AM J CLIN DERMATOL, V18, P355, DOI 10.1007/s40257-017-0251-7
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   Maverakis E, 2018, JAMA DERMATOL, V154, P461, DOI 10.1001/jamadermatol.2017.5980
   Monari P, 2018, INT WOUND J, V15, P875, DOI 10.1111/iwj.12939
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   Xia FD, 2018, J AM ACAD DERMATOL, V78, P310, DOI 10.1016/j.jaad.2017.09.040
NR 9
TC 1
Z9 1
U1 1
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E39
EP E41
DI 10.25270/wnds/22065
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500010
PM 36749997
DA 2026-07-24
ER

PT J
AU Eleftheriadou, I
   Samakidou, G
   Tentolouris, A
   Papanas, N
   Tentolouris, N
AF Eleftheriadou, Ioanna
   Samakidou, Georgia
   Tentolouris, Anastasios
   Papanas, Nikolaos
   Tentolouris, Nikolaos
TI Nonpharmacological Management of Diabetic Foot Ulcers: An Update
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE diabetic foot ulcers; advanced treatments; standard of care; wound
   healing
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY;
   EPIDERMAL-GROWTH-FACTOR; DOUBLE-BLIND; STEM-CELLS; ENZYMATIC
   DEBRIDEMENT; MEMBRANE ALLOGRAFT; HUMAN SKIN; MULTICENTER; EFFICACY
AB Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus that is associated with increased morbidity and mortality, as well as substantial economic burden for the health care system. The standard of care for DFUs includes pressure off-loading, sharp debridement, and wound moisture balance, along with infection control and management of peripheral arterial disease. A variety of advanced modalities that target distinct pathophysiological aspects of impaired wound healing in diabetes are being studied as possible adjunct therapies for difficult to heal ulcers. These modalities include growth factors, stem cells, cultured fibroblasts and keratinocytes, bioengineered skin substitutes, acellular bioproducts, human amniotic membranes, oxygen therapy, negative pressure wound therapy, and energy therapies. Additionally, the use of advanced biomaterials and gene delivery systems is being investigated as a method of effective delivery of substances to the wound bed. In the present narrative review, we outline the latest advances in the nonpharmacological management of DFUs and summarize the efficacy of various standard and advanced treatment modalities.
C1 [Eleftheriadou, Ioanna; Samakidou, Georgia; Tentolouris, Anastasios; Tentolouris, Nikolaos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, Sch Med, Athens, Greece.
   [Eleftheriadou, Ioanna; Samakidou, Georgia; Tentolouris, Anastasios; Tentolouris, Nikolaos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Ctr Diabet, Sch Med, Athens, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Alexandroupolis, Greece.
C3 Laiko General Hospital; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Laiko General Hospital;
   Democritus University of Thrace
RP Papanas, N (通讯作者)，Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, Diabet Ctr,Med Sch, 17 Agiou Thoma St, Athens 11527, Greece.
EM ntentol@med.uoa.gr
RI ; Tentolouris, Anastasios/AAD-3718-2019
OI Samakidou, Georgia/0000-0001-5567-8044; Eleftheriadou,
   Ioanna/0000-0003-2763-2481; PAPANAS, NIKOLAOS/0000-0002-7320-785X; 
CR [Anonymous], 2013, BIOMED RES INT
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NR 113
TC 34
Z9 38
U1 1
U2 34
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2021
VL 20
IS 3
BP 188
EP 197
AR 1534734620963561
DI 10.1177/1534734620963561
EA OCT 2020
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA TY5OX
UT WOS:000583683800001
PM 33073653
DA 2026-07-24
ER

PT J
AU Wang, L
   Lv, YJ
   Zhao, GX
   Li, GJ
   He, ZL
   Huang, YC
   Zhao, GQ
AF Wang, Lei
   Lv, Yunjie
   Zhao, Guoxue
   Li, Guangjian
   He, Zhongliang
   Huang, Yunchao
   Zhao, Guangqiang
TI Therapeutic strategy and efficacy evaluation of chronic empyema after
   total pneumonectomy: individualized analysis of six patients
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Chronic empyema; Postpneumonectomy; Bronchopleural fistula; Autologous
   tissue flap; Open-window thoracostomy
ID VACUUM-ASSISTED CLOSURE; POSTPNEUMONECTOMY EMPYEMA; BRONCHOPLEURAL
   FISTULA; FREE FLAPS; MANAGEMENT
AB BackgroundChronic empyema after total pneumonectomy is a potentially fatal complication.The aim of the study is to explore the treatment strategy and clinical efficacy of chronic empyema after pneumonectomy.MethodsA retrospective analysis of 6 patients with chronic empyema after pneumonectomy in our hospital. Utilizing a staged surgical model, the treatment approach involved rib debridement drainage, open-window thoracostomy (OWT), and the application of autologous tissue flaps, including free myocutaneous flap, pedicled muscle flap, and pedicled greater omentum, to effectively eliminate the abscess cavity.ResultsAll patients with empyema were successfully treated after surgery, with follow-up durations ranging from 3 to 29 months and an average of (10.50 +/- 9.67) months. Re-examination using chest computed tomography (CT) or magnetic resonance imaging (MRI) revealed that the empyema residual cavity had either completely disappeared or had significantly reduced.ConclusionThe treatment of chronic refractory empyema after total pneumonectomy by rib debridement drainage, OWT and autologous tissue flap transplantation has a high cure rate and satisfactory clinical effect.
C1 [Wang, Lei; Lv, Yunjie; Zhao, Guoxue; Li, Guangjian; Huang, Yunchao; Zhao, Guangqiang] Peking Univ, Kunming Med Univ, Yunnan Canc Hosp, Affiliated Hosp 3,Canc Hosp Yunnan,Dept Thorac Sur, 519, Kunzhou Rd, Kunming 650106, Yunnan, Peoples R China.
   [He, Zhongliang] Tongde Hosp Zhejiang Prov, Dept Cardiothorac Surg, Hangzhou 310012, Zhejiang, Peoples R China.
C3 Peking University; Kunming Medical University; Tongde Hospital of
   Zhejiang Province
RP Li, GJ (通讯作者)，Peking Univ, Kunming Med Univ, Yunnan Canc Hosp, Affiliated Hosp 3,Canc Hosp Yunnan,Dept Thorac Sur, 519, Kunzhou Rd, Kunming 650106, Yunnan, Peoples R China.
EM Ligj778402401@163.com
OI Chiang, Chun-Pin/0000-0002-6190-7162
FU National Natural Science Foundation of China [82360490]; National
   Natural Science Foundation of China [82360490] Funding Source: Medline
FX National Natural Science Foundation of China, Grant/Award Number:
   82360490.
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NR 28
TC 4
Z9 5
U1 3
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD DEC 30
PY 2024
VL 19
IS 1
AR 688
DI 10.1186/s13019-024-03246-0
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA R1R6R
UT WOS:001389313100004
PM 38303856
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cho, J
   Sung, K
   Lee, D
AF Cho, Jinbeom
   Sung, Kiyoung
   Lee, Dosang
TI Management of the enteroatmospheric fistula: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Enterocutaneous fistula; Enteroatmospheric fistula; Ventral hernia;
   Complication; Sepsis; Case report
ID OPEN ABDOMEN; ENTERIC FISTULAS
AB BACKGROUND Enteroatmospheric fistula (EAF) is a catastrophic complication that can occur after open abdomen. EAFs cause severe body fluid loss, hypercatabolism, and wound complications, leading to adverse clinical outcomes. CASE SUMMARY A 72-year-old female patient underwent ventral hernia repair. Five days after the surgery, she exhibited severe abdominal pain with septic shock. Exploratory laparotomy revealed extensive intestinal adhesions and severe intraperitoneal contamination. Since the patient was hemodynamically unstable, a salvage operation rather than definite surgery was needed, and three surgical open drains were inserted into the peritoneal cavity. Postoperative EAFs developed, and it was almost impossible to isolate and reduce the fistula output despite the use of vacuum-assisted closure dressings and endoscopic stent insertion. Finally, we anastomosed two vascular grafts to the openings of each EAF to restore enteric continuity. The inserted vascular grafts showed acceptable patency, and the patient could receive optimal nutritional support with elemental enteral feeding. She underwent EAF resection 76 d after graft implantation. CONCLUSION Control of the enteric effluent are key elements in achieving favorable clinical conditions which should precede definite surgery for EAFs.
C1 [Cho, Jinbeom; Sung, Kiyoung; Lee, Dosang] Catholic Univ Korea, Coll Med, Dept Surg, Seoul 06591, South Korea.
   [Lee, Dosang] Catholic Univ Korea, Coll Med, Dept Surg, 222 Banpo Daero, Seoul 06591, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Lee, D (通讯作者)，Catholic Univ Korea, Coll Med, Dept Surg, 222 Banpo Daero, Seoul 06591, South Korea.
EM surgeryds@gmail.com
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NR 14
TC 1
Z9 4
U1 0
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JUL 16
PY 2022
VL 10
IS 20
BP 6954
EP 6959
DI 10.12998/wjcc.v10.i20.6954
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3F8XB
UT WOS:000830944000018
PM 36051143
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Su, LL
   Zheng, JP
   Wang, Y
   Zhang, W
   Hu, DH
AF Su, Linlin
   Zheng, Jianping
   Wang, Yang
   Zhang, Wei
   Hu, Dahai
TI Emerging progress on the mechanism and technology in wound repair
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Wound repair; Inflammation; Immunity; Tissue engineering; Stem cells
ID ACELLULAR DERMAL MATRIX; STEM-CELLS; BREAST RECONSTRUCTION; SKIN; BURN;
   THERAPY; FIBRIN; FUTURE; KERATINOCYTES; REGENERATION
AB Normal wound repair is a dynamic and complex process involving multiple coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure during the repair process may cause chronic wounds or scar formation, which increase the financial burden of patients due to repetitive treatments and considerable medical expenditures, and affect their quality of life. Nowadays, extensive efforts have been made to develop novel therapeutics for wound repair. Genetic engineering technology, tissue engineering technology, stem cell-based therapy, physical and biochemical technology, and vacuum-assisted closure technique have been proposed to be beneficial for wound repair, and shown considerable potential for improving the rate and quality of wound healing and skin regeneration. However, challenges remain as applying these techniques. As the development of cell biology and molecular biology, the understanding of the mechanism under wound repair has gradually deepened. As the growth of interdisciplinary research on physics, chemistry, biology, tissue engineering, and materials, the concept and technique relating wound repair for clinical application have rapidly developed. This article reviews the latest progress on the mechanism and technique in wound repair.
C1 [Su, Linlin; Zhang, Wei; Hu, Dahai] Fourth Mil Med Univ, Xijing Hosp, Dept Burnsand Cutaneous Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Zheng, Jianping] Hubei Univ Arts & Sci, Affiliated Hosp, Xianyang Cent Hosp, Dept Orthoped Surg, Xiangyang 441021, Hubei, Peoples R China.
   [Wang, Yang] Xian Cent Hosp, Dept Burns & Plast Surg, Xian 710000, Shaanxi, Peoples R China.
C3 Air Force Medical University; Hubei University of Arts & Science
RP Su, LL (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Burnsand Cutaneous Surg, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM linlinsu@fmmu.edu.cn
FU Shaanxi Province Key Research & Development Projects [2017kw-043];
   Talent Support Program of Air Force Military Medical University "Project
   Ling Yun"
FX This work was supported by Shaanxi Province Key Research & Development
   Projects (No: 2017kw-043 to L.S.), and the Talent Support Program of Air
   Force Military Medical University "Project Ling Yun" (No: cyjhsll to
   L.S.).
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NR 68
TC 77
Z9 84
U1 1
U2 78
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2019
VL 117
AR 109191
DI 10.1016/j.biopha.2019.109191
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IM2EA
UT WOS:000477804500035
PM 31387187
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Thodis, E
   Kriki, P
   Kakagia, D
   Passadakis, P
   Theodoridis, M
   Mourvati, E
   Vargemezis, V
AF Thodis, Elias
   Kriki, Pelagia
   Kakagia, Despoina
   Passadakis, Ploumis
   Theodoridis, Marios
   Mourvati, Euthymia
   Vargemezis, Vassilios
TI Rigorous Vibrio vulnificus Soft Tissue Infection of the Lower Leg
   in a Renal Transplant Patient Managed by Vacuum Therapy and Autologous
   Growth Factors
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID ASSISTED CLOSURE; PRESSURE; FEATURES; WOUNDS
AB Background. Vibrio vulnificus is a gram-negative marine bacterium that grows well in coastal waters. It is an opportunistic pathogen that can cause serious life-threatening infections in patients with certain health conditions. Vibrio-induced wound infections in immunosuppressed patients are difficult to treat because the healing process may be significantly delayed. Reconstructive surgery may not be successful in early treatment as skin grafts are likely to fail, and there may be increased morbidity of donor sites of grafts or flaps.
   Objective Herein a case of septicemia and wound necrosis owing to V. vulnificus wound infection in a renal transplant patient is reported.
   Method. To conservatively yet adequately debride the wound bed, stimulate angiogenesis, and accelerate granulation, vacuum-assisted closure was employed. Granulation was further enhanced by autologous platelet concentrate spray, which has also been reported to increase the epithelialization rate.
   Result: Complete epithelialization of the wound was achieved 4 weeks after completion of treatment.
   Conclusion: Noninvasive advanced modalities may be employed to successfully treat infectious soft tissue deficits in immunocompromised patients.
C1 [Thodis, Elias] Democritus Univ Thrace Hosp, Dept Nephrol, Alexandroupolis, Greece.
   Democritus Univ Thrace Hosp, Dept Plast Surg, Alexandroupolis, Greece.
   Democritus Univ Thrace Hosp, Burns Unit, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital;
   Democritus University of Thrace; Democritus University Thrace Hospital
RP Thodis, E (通讯作者)，Democritus Univ Thrace Hosp, Dept Nephrol, Alexandroupolis, Greece.
RI Theodoridis, Marios/MZQ-5176-2025; Kakagia, Despoina/AAP-1202-2021
OI Theodoridis, Marios/0000-0002-4993-7668; Kakagia,
   Despoina/0000-0003-2107-6170
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NR 26
TC 4
Z9 6
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JUL-AUG
PY 2009
VL 13
IS 4
BP 209
EP 214
DI 10.2310/7750.2008.08033
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 485AO
UT WOS:000269092900005
PM 19706229
DA 2026-07-24
ER

PT J
AU Morykwas, MJ
   Howell, H
   Bleyer, AJ
   Molnar, JA
   Argenta, LC
AF Morykwas, MJ
   Howell, H
   Bleyer, AJ
   Molnar, JA
   Argenta, LC
TI The effect of externally applied subatmospheric pressure on serum
   myoglobin levels after a prolonged crush/ischemia injury
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE subatmospheric pressure; serum myoglobin levels; crush/ischemia injury;
   acute renal failure
ID ACUTE-RENAL-FAILURE; VACUUM-ASSISTED CLOSURE; CRUSH SYNDROME; WOUND
   CONTROL; REPERFUSION
AB Background: Patients with injuries that cause significant muscle death often develop rhabdomyolysis. The subsequent release and entry of myoglobin into the systemic circulation leads to myoglobinuria, renal injury, and potentially acute renal failure.
   Methods: Large (5 kg) adult rabbits (n = 8) were anesthetized and a 15-kg weight placed on the posterior compartment for 4 hours. After this time, the weight was removed and releasing incisions were made. Subatmospheric pressure (125 mm Hg) was continuously applied to the wounds of four rabbits. Systemic serum samples were obtained at the time of weight removal and at 2, 4, and 8 hours postremoval, and were analyzed for myoglobin content.
   Results: Serum myoglobin levels were similar for both groups at the time of weight removal. Serum myoglobin levels demonstrated a progressive increase with time in nontreated animals, and were significantly elevated compared with subatmospheric pressure-treated animals at all time points (p < 0.001).
   Conclusion: This study shows that application of subatmospheric pressure to an affected body part is associated with lower serum myoglobin levels.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Internal Med, Nephrol Sect, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmorykwa@wfubmc.edu
RI Molnar, Joseph/AEK-5540-2022
OI Morykwas, Michael/0009-0001-5547-5172
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NR 25
TC 34
Z9 42
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2002
VL 53
IS 3
BP 537
EP 540
DI 10.1097/00005373-200209000-00023
PG 4
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 599GA
UT WOS:000178324700031
PM 12352493
DA 2026-07-24
ER

PT J
AU Manta, R
   Magno, L
   Conigliaro, R
   Caruso, A
   Bertani, H
   Manno, M
   Zullo, A
   Frazzoni, M
   Bassotti, G
   Galloro, G
AF Manta, Raffaele
   Magno, Luca
   Conigliaro, Rita
   Caruso, Angelo
   Bertani, Helga
   Manno, Mauro
   Zullo, Angelo
   Frazzoni, Marzio
   Bassotti, Gabrio
   Galloro, Giuseppe
TI Endoscopic repair of post-surgical gastrointestinal complications
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Review
DE Endoscopic clips; Endoscopic treatment; Fistula; Post surgical
   complications; Stenosis; Stents
ID BENIGN ESOPHAGEAL STRICTURES; VACUUM-ASSISTED CLOSURE; LOW ANTERIOR
   RESECTION; COMBINED VICRYL PLUG; ANASTOMOTIC LEAKS; BIODEGRADABLE
   STENTS; MESORECTAL EXCISION; STEROID INJECTION; METALLIC STENTS; BALLOON
AB Complications following gastrointestinal surgery may require re-intervention, can lead to prolonged hospitalization, and significantly increase health costs. Some complications, such as anastomotic leakage, fistula, and stricture require a multidisciplinary approach. Therapeutic endoscopy may play a pivotal role in these conditions, allowing minimally invasive treatment. Different endoscopic approaches, including fibrin glue injection, endoclips, self-expanding stents, and endoscopic vacuum-assisted devices have been introduced for both anastomotic leakage and fistula treatment. Similarly endoscopic treatments, such as endoscopic dilation, incisional therapy, and self-expanding stents have been used for anastomotic strictures. All these techniques can be safely performed by skilled endoscopists, and may achieve a high technical success rate in both the upper and lower gastrointestinal tract. Here we will review the endoscopic management of post-surgical complications; these techniques should be considered as first-line approach in selected patients, allowing to avoid re-operation, reduce hospital stay, and decrease costs. (C) 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Manta, Raffaele; Conigliaro, Rita; Caruso, Angelo; Bertani, Helga; Manno, Mauro] New S Agostino Hosp, Gastroenterol & Endoscopy Unit, Modena, Italy.
   [Magno, Luca; Galloro, Giuseppe] Univ Naples Federico II, Unit Surg Digest Endoscopy, Dept Gen Geriatr Oncol Surg & Adv Technol, Naples, Italy.
   [Bassotti, Gabrio] Univ Perugia, Dept Clin & Expt Med, Gastroenterol & Hepatol Sect, I-06100 Perugia, Italy.
   [Frazzoni, Marzio] New S Agostino Hosp, Digest Pathophysiol Unit, Modena, Italy.
   [Zullo, Angelo] Nuovo Regina Margherita Hosp, Rome, Italy.
C3 University of Naples Federico II; University of Perugia; Poliambulatorio
   Nuovo Regina Margherita
RP Manta, R (通讯作者)，Nuovo Osped S Agostino, Viale Giardini 1355, I-41100 Modena, Italy.
EM r.manta@libero.it
RI Manno, Mauro/T-7626-2017; Frazzoni, Marzio/GZM-6967-2022; Bertani,
   Helga/AAH-9022-2019; Zullo, Angelo/AAV-7092-2020
OI Manno, Mauro/0000-0002-7854-1080; Bertani, Helga/0000-0003-0818-7167;
   Zullo, Angelo/0000-0003-2329-8105; Caruso, Angelo/0000-0001-5285-1315;
   Galloro, Giuseppe/0000-0002-9210-4186
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   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 68
TC 14
Z9 22
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD NOV
PY 2013
VL 45
IS 11
BP 879
EP 885
DI 10.1016/j.dld.2013.03.008
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 233YE
UT WOS:000325604700004
PM 23623147
OA hybrid
DA 2026-07-24
ER

PT J
AU Diener, H
   Herberger, K
   Augustin, M
   Debus, ES
AF Diener, H.
   Herberger, K.
   Augustin, M.
   Debus, E. S.
TI Chronical wound management
SO PHLEBOLOGIE
LA German
DT Review
DE Chronic wounds; Modern wound treatments; Wound dressings
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; ANTIBACTERIAL
   ACTIVITY; DIABETIC-PATIENTS; FOOT; DRESSINGS; THERAPY; MICROBIOLOGY;
   MULTICENTER; PRESSURES
AB Healing a chronic ulceration presents a multifaceted challenge. It requires an initial differentiated clarification of the ulceration entity as the basis for successful treatment. Patience and a corresponding level of patient compliance must be taken into account, as patients are usually showing the signs of a long and difficult ordeal. Socio-economic aspects must also be taken into consideration because treatment costs related to chronic wounds should not be underestimated, particularly in an increasingly elderly society with an ever increasing life expectancy. The previous factors do not only represent a significant stress on the health system, but also present the treating physician with the conundrum of budgeting for long-term, cost-intensive treatment. The lack of consensus and interdisciplinary guidelines is a hindrance in the management of chronic wounds. In contrast, the wound therapist has an ever-increasing range of modern wound treatments, dressings and bandages as well as technical aids, which, due to their specific characteristics, require differentiated applications. Therefore, a restructuring of chronic wound treatment is necessary. This is an overview of modern wound managment and a review of dressings and technical aids.
C1 [Diener, H.] Univ Klin Eppendorf, Univ Herzzentrum Hamburg, Klin Gefassmed, D-20246 Hamburg, Germany.
   [Diener, H.; Herberger, K.; Augustin, M.; Debus, E. S.] Univ Klin Eppendorf, Comprehens Wound Ctr, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Diener, H (通讯作者)，Univ Klin Eppendorf, Univ Herzzentrum Hamburg, Klin Gefassmed, Martininstr 52, D-20246 Hamburg, Germany.
EM h.diener@uke.de
RI Diener, Hans-Christoph/AAF-7275-2019
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NR 47
TC 1
Z9 1
U1 1
U2 22
PU SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
PI STUTTGART
PA HOLDERLINSTRASSE 3, D-70174 STUTTGART, GERMANY
SN 0939-978X
J9 PHLEBOLOGIE
JI Phlebologie
PD DEC
PY 2011
VL 40
IS 6
BP 303
EP +
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 875LE
UT WOS:000299030600003
DA 2026-07-24
ER

PT J
AU Dietz, UA
   Spor, L
   Germer, CT
AF Dietz, U. A.
   Spor, L.
   Germer, C. -T.
TI Management of mesh-related infections
SO CHIRURG
LA German
DT Article
DE Hernia; Surgical mesh; Antibiotic prophylaxis; Infection;
   Vacuum-assisted closure
ID VENTRAL HERNIA REPAIR; INCISIONAL HERNIAS; CLASSIFICATION;
   COMPLICATIONS; METAANALYSIS
AB Infections of an implanted hernia mesh are a major challenge. The incidence of mesh infections after incisional hernia repair is about 1% for endoscopic techniques and can be more than 15% in open techniques. Intraoperative mesh contamination is considered to be the primary cause. All woven or knitted hernia meshes have recesses where bacteria may adhere and establish colonies. The bacterial spectrum for mesh infection includes skin pathogens, such as Staphylococcus aureus (including MRSA), Streptococcus spp., as well as E. coli, Enterococcus and Mycobacteria. The therapy approach needs to be tailored to the morphological findings and the treatment for uncomplicated phlegmon is broad spectrum antibiotic therapy. If there is encapsulated fluid accumulation, CT-controlled drainage and daily infusion of antiseptics via the drain is a good option. For dermal necrosis, mesh fistula, exposed mesh or enterocutaneous fistula, a precise CT evaluation is necessary to tailor the operation. Vacuum systems are gaining increased acceptance in conditioning the local findings. For most patients the therapeutic concept will be based on individual decisions. If parts of a formerly infected mesh remain in the patient, a lifelong follow-up is necessary.
C1 [Dietz, U. A.; Spor, L.; Germer, C. -T.] Univ Klinikum Wurzburg, Klin & Poliklin Allgemein Viszeral Gefass & Kinde, D-97080 Wurzburg, Germany.
C3 University of Wurzburg
RP Dietz, UA (通讯作者)，Univ Klinikum Wurzburg, Klin & Poliklin Allgemein Viszeral Gefass & Kinde, Oberdurrbacher Str 6, D-97080 Wurzburg, Germany.
EM dietz_u@chirurgie.uni-wuerzburg.de
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NR 30
TC 21
Z9 25
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
J9 CHIRURG
JI Chirurg
PD MAR
PY 2011
VL 82
IS 3
BP 208
EP +
DI 10.1007/s00104-010-2013-4
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 737GZ
UT WOS:000288558400003
PM 21327906
DA 2026-07-24
ER

PT J
AU Ozturk, GY
   Kocyigit, BF
AF Ozturk, Gulsah Yasa
   Kocyigit, Burhan Fatih
TI Healing refractory livedoid vasculopathy-related skin ulcers by ozone
   therapy: a case-based review
SO RHEUMATOLOGY INTERNATIONAL
LA English
DT Review
DE Ozone; Wound healing; Skin ulcer; Rheumatology; Rheumatic diseases
ID AUTOHEMOTHERAPY; VASCULITIS; ARTHRITIS; EFFICACY; MEDICINE
AB Chronic skin wounds represent a prominent etiological factor in the occurrence of non-traumatic foot amputations on a global scale and pose a substantial threat to the patient's well-being and mortality in the absence of effective treatment strategies. There exists a subset of patients that exhibit an insufficient response to different treatment options, comprising antibiotics, dressings, gauze bandages, debridement, rehabilitation, collagen patch, and vacuum-assisted closure. In this patient group, distinct treatment strategies emerge before surgery and amputation. Ozone therapy is one of them. Ozone exhibits a wide variety of effects such as antimicrobial, anti-inflammatory, antioxidant, and trophic. Its trophic effect is mediated by disinfection, stimulation of granulation tissue, acceleration of the angiogenesis process, and detoxification mechanisms. In this article, we presented the beneficial effect of ozone therapy in a case of chronic skin ulcer associated with livedoid vasculopathy. In this context, we aimed to discuss the role of ozone therapy in the management of chronic skin ulcers. Finally, we focused on ozone therapy as a promising method in inflammatory rheumatic diseases.
C1 [Ozturk, Gulsah Yasa; Kocyigit, Burhan Fatih] Univ Hlth Sci, Adana Hlth Practice & Res Ctr, Dept Phys Med & Rehabil, Adana, Turkiye.
C3 University of Health Sciences Turkey
RP Kocyigit, BF (通讯作者)，Univ Hlth Sci, Adana Hlth Practice & Res Ctr, Dept Phys Med & Rehabil, Adana, Turkiye.
EM bfk2701@hotmail.com
RI Yaşa Öztürk, Gülşah/JTT-1828-2023; Koçyiğit, Burhan Fatih/AAX-4980-2021
OI Yaşa Öztürk, Gülşah/0000-0002-9033-5095; Koçyiğit, Burhan
   Fatih/0000-0002-6065-8002
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NR 44
TC 6
Z9 6
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0172-8172
EI 1437-160X
J9 RHEUMATOL INT
JI Rheumatol. Int.
PD FEB
PY 2024
VL 44
IS 2
BP 369
EP 377
DI 10.1007/s00296-023-05504-1
EA NOV 2023
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA FD2B3
UT WOS:001113544700002
PM 37999797
DA 2026-07-24
ER

PT J
AU Buote, NJ
AF Buote, Nicole J.
TI Updates in Wound Management and Dressings
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Wound healing; Wound management; Topical wound treatments; Fish skin
   dressing; Bioelectric dressing; Leeches; Regenerative medicine wound
   treatments; Bandaging
ID VACUUM-ASSISTED CLOSURE; COATED FOAM DRESSINGS; LEVEL LASER THERAPY;
   BIOPHOTONIC SYSTEM; MESENCHYMAL STEM; PRESSURE; SKIN; EFFICACY; DOGS;
   FIELD
AB Introduction Wound management is an ever-changing field in veterinary medicine with the advent of new cellular treatments and new topical dressings occurring all the time. The care of patients with wounds is performed by veterinarians of all experience levels and across the world with each locale enduring unique challenges. There are differences in wound healing depending on causation, comorbidities, and species that must always be taken into account and owners' finances and availability of care also play significant roles in management decisions. To choose the most beneficial treatment, a thorough understanding of the phases of wound healing is a necessity as each treatment is specifically tailored to benefit certain phases. While this chapter will not discuss the initial management of wounds (clipping, cleaning, flushing, debridement, and so forth), it will provide a brief review of the phases of wound healing, specific anatomic and patient considerations, and species differences. The majority of the chapter will then focus on innovative treatment modalities and dressings and when best to use them.
C1 [Buote, Nicole J.] Cornell Univ, Sch Vet Med, Dept Clin Sci, Small Anim Surg Soft Tissue Sect, 930 Campus Rd, Ithaca, NY 14853 USA.
C3 Cornell University
RP Buote, NJ (通讯作者)，Cornell Univ, Sch Vet Med, Dept Clin Sci, Small Anim Surg Soft Tissue Sect, 930 Campus Rd, Ithaca, NY 14853 USA.
RI Buote, Nicole/HKF-2946-2023
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NR 89
TC 18
Z9 25
U1 0
U2 40
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD MAR
PY 2022
VL 52
IS 2
BP 289
EP 315
DI 10.1016/j.cvsm.2021.12.001
EA FEB 2022
PG 27
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA ZG6DD
UT WOS:000760346400001
PM 35082098
DA 2026-07-24
ER

PT J
AU Franklin, ME
   Alvarez, A
   Russek, K
AF Franklin, Morris E.
   Alvarez, Allen
   Russek, Karla
TI Negative Pressure Therapy: A Viable Option for General Surgical
   Management of the Open Abdomen
SO SURGICAL INNOVATION
LA English
DT Review
DE nontraumatic surgery; open abdomen; temporary abdominal closure
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; FASCIAL CLOSURE;
   WOUND CLOSURE; VENTRAL HERNIA; DAMAGE CONTROL; PACK TECHNIQUE;
   EXPERIENCE; TRAUMA
AB Background. Management of the open abdomen (OA) is challenging for surgeons and requires experienced medical teamwork. The need for improvements in temporary abdominal closure methods has led to the development of a negative-pressure therapy (NPT; ABThera OA NPT, KCI USA, Inc, San Antonio, TX). Method. The authors present a 19-patient case series documenting their use of NPT for OA management in nontraumatic surgery. All received NPT until the fascia was considered ready for closure. Results. Of 19 patients, 17 (89.5%) achieved fascial closure with a Kaplan-Meier (KM) median time to closure of 6 days. Mean hospital and intensive care unit stays were 32.1 and 26.6 days, respectively. During their hospitalization, 5 patients (26.3%) died, with a KM median time to mortality of 53 days. Conclusion. These findings demonstrate effective use of NPT for managing the OA in critically ill patients, and this has led the authors to use it in their general surgery practice.
C1 [Franklin, Morris E.; Alvarez, Allen; Russek, Karla] Texas Endosurg Inst, San Antonio, TX 78222 USA.
RP Franklin, ME (通讯作者)，Texas Endosurg Inst, 4242 E Southcross Blvd,Suite 1, San Antonio, TX 78222 USA.
EM fellow@texasendosurgery.com
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NR 32
TC 11
Z9 11
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD DEC
PY 2012
VL 19
IS 4
BP 353
EP 363
DI 10.1177/1553350611429693
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 031ZH
UT WOS:000310680900002
PM 22228757
DA 2026-07-24
ER

PT J
AU Pancholy, B
   Raman, J
AF Pancholy, Bharat
   Raman, Jai
TI Chest Wall Reconstruction Using Sternal Plating in Patients With Complex
   Sternal Dehiscence
SO ANNALS OF THORACIC SURGERY
LA English
DT Editorial Material
ID WOUND-INFECTION; MANAGEMENT; CLOSURE
AB To evaluate the effectiveness of sternal reconstruction using demineralized bone matrix in patients with complex sternal dehiscence. In this retrospective review, 14 patients with complex sternal wounds with dehiscence were evaluated after specific reconstructive methods. The steps involved ensuring sternal salvage by eradicating infection with a combination of vacuum assisted closure and antibiotic therapy. In a separate setting, patients underwent sternal reconstruction with plate fixation and local use of bone morphogenetic protein (BMP; Infuse, Medtronic, Minneapolis, MN) and demineralized bone matrix for remaining sternal defects. Pectoral myocutaneous flaps were then used to cover the sternum. Patients were evaluated daily in the immediate postoperative period for sternal wound complications and pain and were followed up at 3 and 6 months postoperatively. At 6 month after the procedure, all patients had stable chest walls with no further sternal instability and no recurrent dehiscences or wound infections. All patients returned to normal activity with complete resolution of sternal pain. Complex sternal wounds can be reconstructed and repaired effectively with a combination of bone salvage, local therapy with BMP, and flap closure, with encouraging results. (C) 2015 by The Society of Thoracic Surgeons
C1 [Pancholy, Bharat; Raman, Jai] Rush Univ, Med Ctr, Dept Thorac & Cardiovasc Surg, Chicago, IL 60612 USA.
C3 Rush University
RP Pancholy, B (通讯作者)，Tampa VA Hosp, Dept Surg 112, Dept Cardiothorac Surg, 13000 Bruce B Downs Blvd, Tampa, FL 33612 USA.
EM bharat.pancholy@va.gov
RI Raman, Jaishankar/K-1219-2019
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NR 8
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2015
VL 99
IS 6
BP 2228
EP 2230
DI 10.1016/j.athoracsur.2015.02.018
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA CM2OT
UT WOS:000357521600075
PM 26046891
DA 2026-07-24
ER

PT J
AU Weidenhagen, R
   Hatz, RA
AF Weidenhagen, R
   Hatz, RA
TI Moist wound healing in postoperative and chronic wounds
SO GYNAKOLOGE
LA German
DT Article
DE chronic wound; moist wound healing; wound dressing; postoperative wound
   healing; wound debridement
ID VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS; RISK-FACTORS; HYDROCOLLOID
   DRESSINGS; OCCLUSIVE DRESSINGS; CALCIUM ALGINATE; SITE INFECTION; DERMAL
   REPAIR; WATER CONTACT; SURGERY
AB impairment of wound healing may have different causes during the pre-, intraoperative and postoperative periods. They may be due to trauma, chronic diseases s. a. diabetes or arteriosclerosis or they may be encountered following surgical procedures. Acute wound healing disorders need prompt and adequate intervention. Conventional treatment modalities using different locally applicable lotions or tinctures are still widely applied as is the simple dressing of the wound using dry compresses. However, wound dressings have evolved throughout the last 10 to 15 years considerably. The first line of treatment is proper wound debridement and infection control, Modern wound dressings should be applied since they have been proven to be more effective in various clinical controlled studies. Therefore, the physician should inform himself about the different dressings available at the moment and how each category interacts with different phases of the wound healing process. Proper selection of the most efficient dressing type depends on different characteristics of the wound, of its location and its momentary stage of healing.
C1 Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, D-81377 Munich, Germany.
C3 University of Munich
RP Weidenhagen, R (通讯作者)，Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, D-81377 Munich, Germany.
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NR 65
TC 2
Z9 2
U1 2
U2 16
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0017-5994
J9 GYNAKOLOGE
JI Gynakologe
PD DEC
PY 2002
VL 35
IS 12
BP 1241
EP 1248
DI 10.1007/s00129-002-1307-0
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 629GD
UT WOS:000180041300010
DA 2026-07-24
ER

PT J
AU Bleszynski, MS
   Chan, T
   Buczkowski, AK
AF Bleszynski, Michael S.
   Chan, Tiffany
   Buczkowski, Andrzej K.
TI Comparison of inflammatory cytokines in peritoneal fluid at source
   control surgery for abdominal sepsis
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID HEPATOCYTE GROWTH-FACTOR; MORTALITY; RESPONSES; THERAPY; INJURY; CELLS
AB Background: Open abdomen with vacuum assisted closure (VAC) is an alternate method to primary abdominal closure (PAC) in select situations for the management of severe surgical abdominal sepsis or septic shock. Peritoneal cytokines may potentially correlate with deranged physiology and help stratify severity of sepsis. The primary objective of the study was to identify if cytokines can differentiate between patients who underwent PAC or VAC at primary source control laparotomy (SCL).
   Methods: Prospective case series including patients with severe abdominal sepsis/septic shock requiring urgent SCL. Peritoneal fluid (PF) was collected intra-operatively and blood samples were collected pre- and post SCL. Samples were analyzed with a Cytokine 30-plex Panel. APACHE-IV was used as a measure of disease severity between groups.
   Results: 4 PAC and 8 VAC patients were included. PF concentrations of IL 6, IL-17, IL-5 and HGF were significantly elevated in VAC compared to PAC. Serum RANTES was increased in survivors compared to non-survivors.
   Conclusions: Patients who received VAC management had a more severe degree of local abdominal sepsis based on significantly elevated peritoneal cytokines. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Bleszynski, Michael S.; Chan, Tiffany; Buczkowski, Andrzej K.] Univ British Columbia, Dept Gen Surg, Div Gen Surg, Vancouver, BC, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Fac Med, Dept Surg, Div Gen Surg,Vancouver Gen Hosp, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
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NR 30
TC 7
Z9 7
U1 0
U2 4
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2017
VL 213
IS 5
BP 849
EP 855
DI 10.1016/j.amjsurg.2017.03.037
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EY4HJ
UT WOS:000403937900004
PM 28456342
DA 2026-07-24
ER

PT J
AU Forcignano, E
   Verra, M
   Lo Secco, G
   Arezzo, A
AF Forcignano, Edoardo
   Verra, Mauro
   Lo Secco, Giacomo
   Arezzo, Alberto
TI Endoscopic Management of Anastomotic Insufficiencies in the Lower GI
   Tract
SO VISCERAL MEDICINE
LA English
DT Review
DE Anastomotic leakage; Colorectal surgery; Endoscopy; Postoperative
   complication; Endoscopic vacuum therapy; Suturing device
ID VACUUM-ASSISTED CLOSURE; LOW ANTERIOR RESECTION; SCOPE CLIP OTSC;
   COLORECTAL ANASTOMOSES; DEFUNCTIONING STOMA; LEAKAGE; CANCER; THERAPY;
   PERFORATIONS; EXPERIENCE
AB Background: Anastomotic leaks and fistulas are a feared and challenging postoperative complication in colorectal surgery. Traditionally managed with protective ileostomy and revisional surgery, less-invasive endoscopic approaches are increasingly being utilized. Summary: This article provides a comprehensive overview of current endoscopic treatment principles for managing anastomotic leaks after colorectal surgery. These approaches can be categorized into three main strategies: endoscopic negative pressure therapy - using negative pressure via polyurethane foam drains to promote wound healing and drain secretions; direct closure techniques - including endoscopic suturing systems (e.g., OverStitch) and clipping devices (e.g., over-the-scope clip) to approximate tissue and close defects; and vacuum stenting - a hybrid approach that combines negative pressure therapy with defect coverage using a covered self-expanding metal mesh stent (VAC-stent). Each method offers unique advantages depending on the leak characteristics and timing of detection. Early diagnosis and individualized treatment selection are critical to successful outcomes. Key Messages: Endoscopic treatment of anastomotic insufficiencies represents a minimally invasive, effective and safe alternative to traditional surgical interventions, particularly in clinically stable patients.
C1 [Forcignano, Edoardo; Verra, Mauro; Lo Secco, Giacomo; Arezzo, Alberto] Univ Turin, Dept Surg Sci, Turin, Italy.
C3 University of Turin
RP Forcignano, E (通讯作者)，Univ Turin, Dept Surg Sci, Turin, Italy.
EM e.forcignano@gmail.com
RI /AAD-3487-2020; Arezzo, Alberto/AAB-6552-2020; Forcignanò,
   Edoardo/AAO-3899-2020
OI Arezzo, Alberto/0000-0002-2110-4082; 
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NR 48
TC 1
Z9 1
U1 1
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2025
VL 41
IS 4
BP 191
EP 199
DI 10.1159/000547021
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 5IJ8A
UT WOS:001536410600001
PM 40688737
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Saul, D
   Dresing, K
AF Saul, D.
   Dresing, K.
TI Treatment of traumatic lesions of the bursa olecrani and chronic
   bursitis olecrani
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Bursectomy; Bursitis; Elbow; Olecranon; Wound healing
ID SEPTIC BURSITIS; PREPATELLAR BURSITIS; MANAGEMENT; DIAGNOSIS; WOUNDS;
   EMERGENCY; CLOSURE
AB Complete olecranon bursectomy with debridement, protection of veins and nerves. Risk-adapted antibiotic therapy and early functional aftercare.
   Acute, traumatic laceration of the bursa olecrani, chronic therapy-resistant bursitis olecrani.
   For traumatic bursa injuries: general contraindications for anesthesia and surgery; chronic bursitis: initially not closable skin defect (plastic surgery required), hemodynamically instable patient (e.g. systemic inflammatory response syndrome [SIRS] or sepsis), pre-existing skin infection.
   Local anesthesia beyond the lesion, careful debridement, identification and removal of the entire bursa, excision of contaminated skin, lavage, drain insertion (Redon, Easy-flow, Penrose). Wound closure, elastic bandage, and splint.
   Elastic bandage for 2 days, followed by drain removal. Wound assessment, early functional aftercare without splint, antibiotic therapy in septic bursitis for 2 weeks, PRICE scheme. Removal of stitches after 10-12 days.
   Over 5 years, 138 cases of traumatic bursa lesion or chronic bursitis olecrani were treated in our clinic, 82 patients underwent surgery. Ten patients were treated with vacuum-assisted closure therapy and consecutive wound healing; fistulae occurred in two patients and in another two dehiscence developed. All of the defects could be closed without flaps.
C1 [Saul, D.; Dresing, K.] Univ Med Gottingen, Klin Unfallchirurg Orthopadie & Plast Chirurg, Robert Koch Str 40, D-37075 Gottingen, Germany.
C3 University of Gottingen
RP Saul, D (通讯作者)，Univ Med Gottingen, Klin Unfallchirurg Orthopadie & Plast Chirurg, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM Dominik.Saul@med.uni-goettingen.de
RI Saul, Dominik/K-7355-2019; Dresing, Klaus/I-1781-2019
OI Saul, Dominik/0000-0002-0673-3710; 
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NR 43
TC 1
Z9 1
U1 0
U2 4
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
EI 1439-0981
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD JUL
PY 2017
VL 29
IS 3
BP 253
EP 265
DI 10.1007/s00064-017-0483-y
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EX8NB
UT WOS:000403505900006
PM 28175943
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Steenvoorde, P
   Rozeboom, AL
   Melief, P
   Kraemer, CV
   Bonsing, BA
AF Steenvoorde, P
   Rozeboom, AL
   Melief, P
   Kraemer, CV
   Bonsing, BA
TI Failure of the topical negative pressure abdominal dressing system in
   the "fat" open abdomen: Report of a case and review of the literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEVERE INTRAABDOMINAL INFECTION; FASCIAL
   CLOSURE; VENTRAL HERNIA; WOUND CLOSURE; THERAPY; LAPAROSTOMY;
   MANAGEMENT; DEVICE
AB An obese patient presented with a Candida albicans ventriculitis and peritonitis after a ventriculo-peritoneal drain became infected. The open abdomen (laparostomy) was treated with a topical negative pressure (TNP) abdominal dressing system. The patient was first treated with an ileocecal resection, which was later complicated by an abdominal compartment syndrome for which a laparostomy was needed. With the TNP abdominal dressing system alone, the abdominal fascia showed extreme retraction. In the literature, several authors propose the combination of sutures with the TNP system in order to approximate wound edges. The herein described combination of the TNP abdominal dressing system with a progressive Bogota bag closure is based on the same principles. Despite aggressive surgical and medical therapy, the patient eventually died of a systemic Pseudomonas infection. The TNP abdominal dressing system alone may not be powerful enough to prevent retraction of the fascia. Combination with progressive Bogota bag closure prevents this but still preserves the essential beneficial effects of the TNP abdominal dressing system.
C1 Rijnland Hosp Leiderdorp, NL-2353 GA Leiderdorp, Netherlands.
   Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.
   Leiden Univ, Med Ctr, Dept Intens Care, Leiden, Netherlands.
C3 Rijnland Hospital; Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC)
RP Steenvoorde, P (通讯作者)，Rijnland Hosp Leiderdorp, Simon Smitweg 1, NL-2353 GA Leiderdorp, Netherlands.
EM p.steenvoorde@rijnland.nl
RI Elzo Kraemer, Carlos V/HPG-5875-2023
OI Elzo Kraemer, Carlos V/0000-0002-5426-9334
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NR 42
TC 4
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2006
VL 18
IS 2
BP 44
EP +
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 018YC
UT WOS:000235799700005
DA 2026-07-24
ER

PT J
AU Chan, T
   Bleszynski, MS
   Youssef, DS
   Segedi, M
   Chung, S
   Scudamore, CH
   Buczkowski, AK
AF Chan, T.
   Bleszynski, M. S.
   Youssef, D. S.
   Segedi, M.
   Chung, S.
   Scudamore, C. H.
   Buczkowski, A. K.
TI Open abdomen in liver transplantation
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; DAMAGE CONTROL; LAPAROTOMY; COMPLICATIONS;
   SURGERY; PATIENT
AB Introduction: Damage control laparotomy with vacuum assisted closure (VAC) is used for selective cases in trauma. In liver transplantation, VAC has also been applied for management of intra-operative hemorrhage. The primary objective was to evaluate pen-operative blood loss and blood product utilization in VAC compared to primary abdominal closure (PAC) at the index transplant operation.
   Methods: Retrospective review of all adults undergoing deceased donor liver transplantation (2007 2011) at a single center tertiary care institution.
   Results: 201 deceased donor liver transplantations were performed, with 167 PAC and 34 VAC cases. Intra-operative blood loss (4.4L vs 10.7L), cell saver return (1399 ml vs 3998 ml), FFP (7.6U vs 15.9U) and PLT requirements (8.5U vs 18.3U), were all significantly elevated in VAC compared to PAC. VAC patients had significantly increased RBC, FFP, PLT, and total volume requirements during initial ICU admission. 30 PAC cases required on demand laparotomy and most commonly for post-operative bleeding.
   Conclusion: In liver transplantation, application of VAC secondary to massive intra-operative exsanguination was safely utilized. Further evaluation is required to identify long-term morbidity and mortality. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Chan, T.; Bleszynski, M. S.; Youssef, D. S.; Segedi, M.; Chung, S.; Scudamore, C. H.; Buczkowski, A. K.] Univ British Columbia, Dept Gen Surg, Div Gen Surg, Vancouver, BC, Canada.
C3 University of British Columbia
RP Bleszynski, MS (通讯作者)，Univ British Columbia, Vancouver Gen Hosp, Fac Med, Dept Surg,Div Gen Surg, Rm 3100 Jim Pattison Pavill North, Vancouver, BC V5Z 1M9, Canada.
EM mbleszyn@gmail.com
CR Asensio JA, 2001, AM J SURG, V182, P743, DOI 10.1016/S0002-9610(01)00809-1
   Chiara O, 2016, J TRAUMA ACUTE CARE, V80, P173, DOI 10.1097/TA.0000000000000882
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NR 14
TC 4
Z9 5
U1 1
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2018
VL 215
IS 5
BP 782
EP 785
DI 10.1016/j.amjsurg.2017.12.012
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GG1TB
UT WOS:000432469100005
PM 29448990
DA 2026-07-24
ER

PT J
AU Guler, A
   Durukan, AB
   Gurbuz, HA
   Tavlasoglu, M
   Sahin, MA
   Jahollari, A
   Yorgancioglu, C
   Aslan, M
AF Guler, Adem
   Durukan, Ahmet Baris
   Gurbuz, Hasan Alper
   Tavlasoglu, Murat
   Sahin, Mehmet Ali
   Jahollari, Artan
   Yorgancioglu, Cem
   Aslan, Mehmet
TI Efficacy of Thermoreactive Nitinol Clip Implantation in Reconstruction
   of Sternal Dehiscence
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; WOUND-INFECTION; COMPLICATIONS
AB Background: Sternal dehiscence is a severe complication of open heart surgery. Reinforced wiring, a system of reinforced sternal closure, fixation of a rigid plate, and implantation of thermoreactive nitinol clips (TRC) are some surgical procedures used. The aim of this study was to evaluate the role of TRC for secondary sternal reconstruction.
   Methods: Of 1198 patients who underwent their operations via median sternotomy in 2 separate medical centers, sternal dehiscence was observed in 16 patients overall (1.33%). The mean (SD) age of the patients was 64.06 +/- 9.18 years (range, 40-77 years). Sternal dehiscence was diagnosed in all patients between the fifth and 30th postoperative days.
   Results: TRC were implanted in all of the patients who developed sternal dehiscence (16 patients). One patient developed severe respiratory failure, became ventilator dependent, and died from pneumonia on postoperative day 24. The other 15 patients were discharged without complications. Postoperative follow-up of the surviving patients revealed adequate and satisfactory sternal stability.
   Conclusion: Implantation of TRC is an effective and easy method for fixing the sternum and can be performed rapidly and securely.
C1 [Guler, Adem; Sahin, Mehmet Ali; Jahollari, Artan; Aslan, Mehmet] Gulhane Mil Med Acad, Dept Cardiovasc Surg, Ankara, Turkey.
   [Durukan, Ahmet Baris; Gurbuz, Hasan Alper; Yorgancioglu, Cem] Medicana Int Ankara Hosp, Dept Cardiovasc Surg, Ankara, Turkey.
   [Tavlasoglu, Murat] Diyarbakir Mil Hosp, Dept Cardiovasc Surg, Diyarbakir, Turkey.
C3 Gulhane Training & Research Hospital; Medicana Hospital; Diyarbakir
   Military Hospital
RP Durukan, AB (通讯作者)，Umit Mahallesi 2463,Sokak 4-18, TR-06810 Ankara, Turkey.
EM barisdurukan@yahoo.com
RI ; TAVLAŞOĞLU, Murat/G-4122-2013; Durukan, Ahmet Baris/Q-6984-2019;
   Sahin, Mehmet/NNG-6003-2025
OI Gurbuz, Hasan Alper/0000-0002-3291-4443; TAVLAŞOĞLU,
   Murat/0000-0003-1943-9286; Durukan, Ahmet Baris/0000-0003-0566-0350; 
CR Avlonitis VS, 2008, ANN THORAC SURG, V85, P2164, DOI 10.1016/j.athoracsur.2007.12.014
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NR 12
TC 3
Z9 3
U1 0
U2 4
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD OCT
PY 2012
VL 15
IS 5
BP E280
EP E283
DI 10.1532/HSF98.20121056
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 033FI
UT WOS:000310779200008
PM 23092666
OA gold
DA 2026-07-24
ER

PT J
AU Wettstein, M
   Frieling, T
   Lüthen, R
   Heintges, T
   Niederau, C
   Oette, M
   Vogt, C
   vom Dahl, S
AF Wettstein, M.
   Frieling, T.
   Luethen, R.
   Heintges, T.
   Niederau, C.
   Oette, M.
   Vogt, C.
   vom Dahl, S.
TI Endoscopic Therapy for Leaks in the Gastrointestinal Tract, the Bile
   Ducts and the Pancreas
SO ZEITSCHRIFT FUR GASTROENTEROLOGIE
LA German
DT Review
DE perforations; anastomotic leaks; endoscopic treatment;
   over-the-scope-clip; stenting
ID VACUUM-ASSISTED CLOSURE; THE-SCOPE-CLIP; IATROGENIC COLONIC PERFORATION;
   POSTOPERATIVE ESOPHAGEAL LEAKS; LAPAROSCOPIC CHOLECYSTECTOMY;
   COLONOSCOPIC PERFORATIONS; ANASTOMOTIC LEAKS; RISK-FACTORS; PERCUTANEOUS
   MANAGEMENT; COIL EMBOLIZATION
AB Surgery has been the mainstay of therapy in patients with gastrointestinal perforations, leakage or fistulas. New techniques for endoscopic closure of gastrointestinal perforations provide tools for an effective treatment by less invasive procedures. Temporary placement of covered self-expanding stents is an established therapy for oesophageal perforations and anastomotic leaks. Using conventional endoclips small perforations and leaks in the oesophagus and gastrointestinal tract may be closed. With the new over-the-scope-clips a more effective endoscopic full wall closure is possible in the upper gastrointestinal tract and the rectum. Endoscopically guided endoluminal vacuum therapy using polyurethane sponges is an established method for treating rectal leaks and is now increasingly used also in oesophageal leaks. Biliary leakage following endoscopic or surgical interventions is effectively treated with temporary bile stenting in most cases, but closure using metal stents or coiling may be necessary. Pancreatic leaks are a major therapeutic problem and may require multimodal therapies.
C1 [Wettstein, M.] Klinikum Passau, Med Klin 1, D-94036 Passau, Germany.
   [Frieling, T.] Helios Klinikum Krefeld, Med Klin 2, Krefeld, Germany.
   [Luethen, R.] Marien Hosp, Innere Med Klin, Dusseldorf, Germany.
   [Oette, M.] Krankenhaus Augustinerinnen, Klin Allgemeine Innere Med, Cologne, Germany.
   [Vogt, C.] St Josef Krankenhaus Moers, Innere Med Abt, Moers, Germany.
C3 Helios Kliniken; Marien Hospital Dusseldorf; St. Marien Hospital
RP Wettstein, M (通讯作者)，Klinikum Passau, Med Klin 1, Innstr 76, D-94036 Passau, Germany.
EM matthias.wettstein@klinikum-passau.de
RI vom Dahl, Stephan/AAF-8456-2021
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NR 97
TC 5
Z9 7
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-2771
EI 1439-7803
J9 Z GASTROENTEROL
JI Z. Gastroent.
PD JUN
PY 2011
VL 49
IS 6
BP 740
EP 748
DI 10.1055/s-0031-1273422
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 802YG
UT WOS:000293546300006
PM 21638241
DA 2026-07-24
ER

PT J
AU Akhavani, MA
   Sivakumar, B
   Paleolog, EM
   Kang, N
AF Akhavani, Mohammed Ali
   Sivakumar, Branavan
   Paleolog, Ewa M.
   Kang, Norbert
TI Angiogenesis and plastic surgery
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Angiogenesis; Plastic surgery; Flap survival; Tendon healing; Fracture
   healing; Ulcer healing
ID ENDOTHELIAL GROWTH-FACTOR; SKIN FLAP SURVIVAL; RECEPTOR TYROSINE KINASE;
   VACUUM-ASSISTED CLOSURE; GENE-THERAPY; FACTOR VEGF;
   RHEUMATOID-ARTHRITIS; ACHILLES-TENDON; SPLICE VARIANT; SOLID TUMORS
AB Angiogenesis, the formation of new blood vessels from an existing vascular bed, is a normal physiological process which also underpins many - apparently unrelated - pathological states. It is an integral factor in determining the success or failure of many procedures in plastic and reconstructive surgery. As a result, the ability to control the process would be of great therapeutic benefit. To appreciate the potential benefits and limitations of recent advances in our understanding of angiogenesis, it is important to comprehend the basic physiology of blood vessel formation. This review aims to summarise current knowledge of the way in which angiogenesis is controlled and to took at how disordered vessel development results in pathology relevant to plastic surgery. Through this we hope to provide a comprehensive overview of the recent advances in angiogenesis as they relate to plastic surgery, particularly the promotion of flap survival, tendon heating, nerve regeneration, fracture heating and ulcer treatments. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Akhavani, Mohammed Ali; Sivakumar, Branavan; Kang, Norbert] Royal Free Hosp, Dept Plast & Reconstruct Surg, London NW3 2QG, England.
   [Akhavani, Mohammed Ali; Sivakumar, Branavan; Kang, Norbert] Restorat Appearance Funct Trust, Northwood, Middx, England.
   [Akhavani, Mohammed Ali; Sivakumar, Branavan; Paleolog, Ewa M.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst Rheumatol, London, England.
   [Paleolog, Ewa M.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Surg Anaesthet & Intens Care, London, England.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; UCL Medical School; Imperial College London;
   University of Oxford; Kennedy Institute for Rheumatology; Imperial
   College London
RP Akhavani, MA (通讯作者)，Royal Free Hosp, Dept Plast & Reconstruct Surg, Pond St, London NW3 2QG, England.
EM mo@doctors.org.uk
RI /Q-1169-2019
OI Akhavani, Mohmammed Ali/0000-0001-7138-4513
FU Restoration of Appearance and Function Trust; The Dunhill Medical Trust;
   Kennedy Institute of Rheumatotogy [207711]; National Health and Medical
   Research Council (NHMRC) [207711] Funding Source: National Health and
   Medical Research Council (NHMRC); Academy of Finland (AKA) [207711]
   Funding Source: Academy of Finland (AKA)
FX BS and MAA are supported by the Restoration of Appearance and Function
   Trust and are recipients of a Royal College of Surgeons of Engtand (BS
   and MAA)/The Dunhill Medical Trust (MAA) Research Fellowship. The
   Kennedy Institute of Rheumatotogy receives a core grant from arc
   (Registered Charity No. 207711).
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NR 111
TC 36
Z9 38
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2008
VL 61
IS 12
BP 1425
EP 1437
DI 10.1016/j.bjps.2008.05.041
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 381EI
UT WOS:000261518000003
PM 18835232
DA 2026-07-24
ER

PT J
AU Mouës, CM
   Heule, F
   Hovius, SER
AF Moues, C. M.
   Heule, F.
   Hovius, S. E. R.
TI A review of topical negative pressure therapy in wound healing:
   sufficient evidence?
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Review
DE Topical negative pressure therapy; Surgical wounds; Mechanism of action
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; THICKNESS
   SKIN-GRAFTS; DIABETIC FOOT ULCERS; SUBATMOSPHERIC PRESSURE; FASCIAL
   CLOSURE; OPEN ABDOMEN; SEALING-TECHNIQUE; MANAGEMENT; PROGRESSION
AB BACKGROUND: Topical negative pressure (TNP) therapy has become a useful adjunct in the management of various types of wounds. However, the TNP system still has characteristics of a "black box" with uncertain efficacy for many users. We extensively examined the effectiveness of TNP therapy reported in research studies.
   DATA SOURCES: A database search was undertaken, and over 400 peer-reviewed articles related to the use of TNP therapy (animal, human, and in vitro studies) were identified.
   CONCLUSIONS: Almost all encountered studies were related to the use of the commercial VAC device (KCI Medical, United States). Mechanisms of action that can be attributed to TNP therapy are an increase in blood flow, the promotion of angiogenesis, a reduction of wound surface area in certain types of wounds, a modulation of the inhibitory contents in wound fluid, and the induction of cell proliferation. Edema reduction and bacterial clearance, mechanisms that were attributed to TNP therapy, were not proven in basic research. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Moues, C. M.; Hovius, S. E. R.] Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, NL-3000 DR Rotterdam, Netherlands.
   [Heule, F.] Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM c.moues@erasmusmc.nl
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NR 92
TC 142
Z9 178
U1 0
U2 47
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD APR
PY 2011
VL 201
IS 4
BP 544
EP 556
DI 10.1016/j.amjsurg.2010.04.029
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 747HU
UT WOS:000289311700022
PM 21421104
DA 2026-07-24
ER

PT J
AU Papadakos, SP
   Argyrou, A
   Katsaros, I
   Lekakis, V
   Mpouga, G
   Vergadis, C
   Fytili, P
   Koutsoumpas, A
   Schizas, D
AF Papadakos, Stavros P.
   Argyrou, Alexandra
   Katsaros, Ioannis
   Lekakis, Vasileios
   Mpouga, Georgia
   Vergadis, Chrysovalantis
   Fytili, Paraskevi
   Koutsoumpas, Andreas
   Schizas, Dimitrios
TI The Impact of EndoVAC in Addressing Post-Esophagectomy Anastomotic Leak
   in Esophageal Cancer Management
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE EndoVAC; negative pressure wound therapies; NPWT; esophageal cancer;
   endoscopic therapy; esophagectomy; anastomotic leakage
ID ENDOSCOPIC VACUUM THERAPY; CHEMORADIOTHERAPY PLUS SURGERY; UPPER GI
   LEAKS; ASSISTED CLOSURE; NEOADJUVANT CHEMORADIOTHERAPY; SPONGE SOS;
   STENT; COMPLICATIONS; PRESSURE; EPIDEMIOLOGY
AB Anastomotic leakage (AL) remains a major complication after esophagectomy, especially in patients with esophagogastric cancers who have undergone neoadjuvant therapies, which can impair tissue healing. Endoscopic vacuum-assisted closure (EndoVAC) is an innovative approach aimed at managing AL by facilitating wound drainage, reducing infection, and promoting granulation tissue formation, thus supporting effective healing. This review explores the role and effectiveness of EndoVAC in treating AL post-esophagectomy in esophageal cancer patients. We present an overview of its physiological principles, including wound contraction, enhanced tissue perfusion, and optimized microenvironment, which collectively accelerate wound closure. In addition, we examine clinical outcomes from recent studies, which indicate that EndoVAC is associated with improved leak resolution rates and potentially shorter hospital stays compared to traditional methods. Overall, this review highlights EndoVAC as a promising tool for AL management and underscores the need for continued investigation to refine its protocols and broaden its accessibility. By optimizing EndoVACs use, multidisciplinary teams can improve patient outcomes and advance esophageal cancer care.
C1 [Papadakos, Stavros P.; Argyrou, Alexandra; Lekakis, Vasileios; Mpouga, Georgia; Fytili, Paraskevi; Koutsoumpas, Andreas] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Gastroenterol, Athens 11527, Greece.
   [Katsaros, Ioannis; Schizas, Dimitrios] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Surg 1, Athens 11527, Greece.
   [Vergadis, Chrysovalantis] Laikon Gen Hosp, Dept Radiol, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Laiko General Hospital; National & Kapodistrian University of Athens;
   Laiko General Hospital
RP Katsaros, I; Schizas, D (通讯作者)，Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Surg 1, Athens 11527, Greece.
EM stavrospapadakos@gmail.com; argyalex89@gmail.com; ioankats@med.uoa.gr;
   lekakis.vas@gmail.com; gioulibouga@gmail.com; valvergadis@yahoo.gr;
   info@drfytili.gr; andreas.koutsoumpas@laiko.gr; schizasad@gmail.com
RI Schizas, Dimitrios/Z-3323-2019; Katsaros, Ioannis/AHI-2537-2022;
   Papadakos, Stavros/AFF-9357-2022
OI Schizas, Dimitrios/0000-0002-7046-0112; Argyrou,
   Alexana/0000-0002-1569-5592; Katsaros, Ioannis/0000-0002-6743-8942;
   Papadakos, Stavros/0000-0003-1583-1125
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NR 100
TC 6
Z9 7
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 23
AR 7113
DI 10.3390/jcm13237113
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P2U1B
UT WOS:001376514000001
PM 39685572
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cross, WW
   Swiontkowski, MF
AF Cross, William W., III
   Swiontkowski, Marc F.
TI Treatment principles in the management of open fractures
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Review
DE Fracture principles; open fractures; trauma
ID EXTREMITY SEVERITY SCORE; INVASIVE STABILIZATION SYSTEM; VACUUM-ASSISTED
   CLOSURE; OPEN TIBIAL FRACTURES; BONE MORPHOGENETIC PROTEIN-2;
   SOFT-TISSUE RECONSTRUCTION; DISTAL FEMORAL FRACTURES; MANGLED EXTREMITY;
   EXTERNAL FIXATION; SHAFT FRACTURES
AB The management of open fractures continues to provide challenges for the orthopedic surgeon. Despite the improvements in technology and surgical techniques, rates of infection and nonunion are still troublesome. Principles important in the treatment of open fractures are reviewed in this article. Early antibiotic administration is of paramount importance in these cases, and when coupled with early and meticulous irrigation and debridement, the rates of infection can be dramatically decreased. Initial surgical intervention should be conducted as soon as possible, but the classic 6 h rule does not seem to be supported in the literature. All open fractures should be addressed for the risk of contamination from Clostridium tetani . When possible, early closure of open fracture wounds, either by primary means or by flaps, can also decrease the rate of infection, especially from nosocomial organisms. Early skeletal stabilization is necessary, which can be accomplished easily with temporary external fixation. Adhering to these principles can help surgeons provide optimal care to their patients and assist them in an early return to function.
C1 [Cross, William W., III; Swiontkowski, Marc F.] Univ Minnesota, Sch Med, Dept Orthopaed Surg, Minneapolis, MN 55454 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Swiontkowski, MF (通讯作者)，Univ Minnesota, Sch Med, Dept Orthopaed Surg, 2450 Riverside Ave,Suite R200, Minneapolis, MN 55454 USA.
EM swion001@umn.edu
OI Swiontkowski, Marc/0000-0001-7036-1782
CR *AAOS, 2008, INF ORTH PAT COND
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NR 106
TC 114
Z9 149
U1 0
U2 14
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD OCT-DEC
PY 2008
VL 42
IS 4
BP 377
EP 386
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 505WD
UT WOS:000270729100003
PM 19753224
DA 2026-07-24
ER

PT J
AU Risinger, WB
   Smith, JW
AF Risinger, William B.
   Smith, Jason W.
TI Damage control surgery in emergency general surgery: What you need to
   know
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; PRIMARY FASCIAL
   CLOSURE; PERITONEAL RESUSCITATION; INTRAABDOMINAL SEPSIS; TRAUMA
   PATIENTS; OPEN ABDOMEN; ABBREVIATED LAPAROTOMY; PACK TECHNIQUE;
   MANAGEMENT
AB While the utilization of damage control methods in non-traumatic abdominal emergencies is controversial, numerous studies have demonstrated improved outcomes, making damage control surgery an essential technique for all acute care surgeons.
   Damage-control surgery (DCS) is a strategy adopted to limit initial operative interventions in the unstable surgical patient, delaying definitive repairs and abdominal wall closure until physiologic parameters have improved. Although this concept of "physiology over anatomy" was initially described in the management of severely injured trauma patients, the approaches of DCS have become common in the management of nontraumatic intra-abdominal emergencies.While the utilization of damage-control methods in emergency general surgery (EGS) is controversial, numerous studies have demonstrated improved outcomes, making DCS an essential technique for all acute care surgeons. Following a brief history of DCS and its indications in the EGS patient, the phases of DCS will be discussed including an in-depth review of preoperative resuscitation, techniques for intra-abdominal source control, temporary abdominal closure, intensive care unit (ICU) management of the open abdomen, and strategies to improve abdominal wall closure.
C1 [Risinger, William B.; Smith, Jason W.] Univ Louisville, Sch Med, Dept Surg, Louisville, KY USA.
   [Smith, Jason W.] Univ Louisville, Dept Surg, Sch Med, 550 South Jackson St, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Smith, JW (通讯作者)，Univ Louisville, Dept Surg, Sch Med, 550 South Jackson St, Louisville, KY 40202 USA.
EM wbrisi01@louisville.edu; jasonw.smith@louisville.edu
RI ; Smith, Jason/KFS-8741-2024
OI Risinger, William/0000-0003-4591-9494; 
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NR 79
TC 22
Z9 25
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2023
VL 95
IS 5
BP 770
EP 779
DI 10.1097/TA.0000000000004112
PG 10
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA W0YP1
UT WOS:001088974200027
PM 37439768
DA 2026-07-24
ER

PT J
AU Sarkar, B
   Napolitano, LM
AF Sarkar, B.
   Napolitano, L. M.
TI Necrotizing soft tissue infections
SO MINERVA CHIRURGICA
LA English
DT Review
DE Soft tissue infections; Fasciitis, necrotizing; Gas gangrene
ID RESISTANT STAPHYLOCOCCUS-AUREUS; COMPLICATED INTRAABDOMINAL INFECTION;
   LABORATORY RISK INDICATOR; HYPERBARIC-OXYGEN THERAPY;
   TOXIC-SHOCK-SYNDROME; VIBRIO-VULNIFICUS; EMERGENCY-DEPARTMENT; CHILDREN
   GUIDELINES; FOURNIERS GANGRENE; DISEASES SOCIETY
AB Necrotizing soft tissue infections (NSTIs) are aggressive severe soft tissue infection that cause rapid and widespread infection and necrosis of the skin and soft tissues and are highly lethal. NSTIs include necrotizing cellulitis, adipositis, fasciitis and myositis/myonecrosis and have significant potential for extensive soft tissue and limb loss. Early diagnosis and treatment of NSTIs remains the cornerstone of therapy. Timely aggressive surgical debridement and early appropriate antibiotic treatment are required for a successful outcome and clinical cure. Mortality rate has decreased from 25-50% in past years, to 10-16% in recent years with aggressive surgical and medical management. Additional innovative strategies for the treatment of NSTIs, including intravenous immuno-globulin G (WIG), hyperbaric oxygen, and vacuum-assisted closure, do not yet have definitive evidence of efficacy, but may be considered in patients at high risk of death. A comprehensive knowledge of the pathophysiology, diagnostic features, causative microbial pathogens, and treatment strategies (including surgical debridement and antimicrobial therapy) is required for successful management of NSTIs.
C1 [Sarkar, B.; Napolitano, L. M.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Napolitano, LM (通讯作者)，Univ Michigan Hlth Syst, Dept Surg, Room 1C421 Univ Hosp,1500 E Med Dr, Ann Arbor, MI 48109 USA.
EM lenan@umich.edu
RI Napolitano, Lena/AAZ-8651-2021
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NR 102
TC 12
Z9 12
U1 0
U2 9
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD JUN
PY 2010
VL 65
IS 3
BP 347
EP 362
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 654JG
UT WOS:000282163700010
PM 20668422
DA 2026-07-24
ER

PT J
AU Segers, P
   de Jong, AP
   Kloek, JJ
   van der Horst, CM
   Spanjaard, L
   de Mol, BA
AF Segers, P.
   de Jong, A. P.
   Kloek, J. J.
   van der Horst, C. M.
   Spanjaard, L.
   de Mol, B. A.
TI Topical negative pressure therapy in wounds after cardiothoracic
   surgery: Successful experience supported by literature
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE cardiovascular surgery; thoracic surgery; heart valve surgery; coronary
   bypass surgery
ID VACUUM-ASSISTED CLOSURE
AB Background: Patients undergoing cardiothoracic surgery are at substantial risk of developing surgical site infections (SSI). SSI is not only associated with an increased morbidity but also with high mortality. Topical negative pressure therapy (TNP) is a promising method for treating surgical site defects (SSD). In recent years, we have gained a wide experience with TNP in a great variety of SSD. Methods: We completed a prospective follow-up report of all patients treated with TNP after cardiothoracic surgery at the Academic Medical Centre Amsterdam, a university hospital. A review of the current evidence for TNP in cardiothoracic surgery is present. Results: Between August 2000 and March 2005, TNP was used in 105 patients in 113 SSD. As we gained more experience, we saw a decline in hospital stay (p < 0.0001) and duration of TNP therapy. Surgical closure was performed in 62% of patients using simple surgical (reconstructive) techniques. Therapy-related complications were rare (n = 1). Conclusion: Based on clinical findings and supported by the research presented, the treatment modality of choice for SSD after cardiothoracic surgery is TNP.
C1 Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Plast & Reconstruct Surg, NL-1105 AZ Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam
RP Segers, P (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM p.segers@amc.uva.nl
RI Segers, Patrick/IWM-4183-2023; Spanjaard, Lodewijk/ODL-4262-2025
OI van der Horst, chantal/0000-0002-4937-3786; de Mol,
   Bastian/0000-0001-6888-9430
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NR 38
TC 9
Z9 9
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD AUG
PY 2006
VL 54
IS 5
BP 289
EP 294
DI 10.1055/s-2006-924003
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 075QM
UT WOS:000239900300001
PM 16902874
DA 2026-07-24
ER

PT J
AU Chan, SM
   Auyeung, KKY
   Lam, SF
   Chiu, PWY
   Teoh, AYB
AF Chan, Shannon Melissa
   Auyeung, Kitty Kit Ying
   Lam, Siu Fung
   Chiu, Philip Wai Yan
   Teoh, Anthony Yuen Bun
TI Current status in endoscopic management of upper gastrointestinal
   perforations, leaks and fistulas
SO DIGESTIVE ENDOSCOPY
LA English
DT Review
DE anastomotic leak; fistula; gastrointestinal perforation; wound closure
   technique
ID THE-SCOPE-CLIP; LAPAROSCOPIC SLEEVE GASTRECTOMY; EXPANDABLE METAL
   STENTS; VACUUM-ASSISTED CLOSURE; STAPLE-LINE LEAKS; COMBINED VICRYL
   PLUG; ANASTOMOTIC LEAKAGE; ESOPHAGEAL PERFORATIONS; MULTICENTER
   EXPERIENCE; BARIATRIC SURGERY
AB Recent advancement in endoscopic closure techniques have revolutionized the treatment of gastrointestinal perforations, leaks and fistulas. Traditionally, these have been managed surgically. The treatment strategy depends on the size and location of the defect, degree of contamination, presence of healthy surrounding tissues, patients' condition and the availability of expertise. One of the basic principles of management includes providing a barricade to the flow of luminal contents across the defect. This can be achieved with a wide range of endoscopic techniques. These include endoclips, stenting, suturing, tissue adhesives and glue, and endoscopic vacuum therapy. Each method has their distinct indications and shortcomings. Often, a combination of these techniques is required. Apart from endoscopic closure, drainage procedures by the interventional radiologist and surgical management also play an important role. In this review article, the outcomes of each of these endoscopic closure techniques in the literature is provided in tables, and practical management algorithms are being proposed.
C1 [Chan, Shannon Melissa; Auyeung, Kitty Kit Ying; Lam, Siu Fung; Chiu, Philip Wai Yan; Teoh, Anthony Yuen Bun] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China.
C3 Prince of Wales Hospital Hong Kong; Chinese University of Hong Kong
RP Chan, SM (通讯作者)，Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China.
EM shannonchan@surgery.cuhk.edu.hk
RI Chiu, Philip/A-4019-2009; Teoh, Anthony/L-4796-2016
OI Teoh, Anthony/0000-0002-1885-8035; AU-YEUNG, Kit
   Ying/0000-0003-4217-6568; Chan, Shannon Melissa/0000-0001-6280-4176
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NR 170
TC 30
Z9 36
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0915-5635
EI 1443-1661
J9 DIGEST ENDOSC
JI Dig. Endosc.
PD JAN
PY 2022
VL 34
IS 1
BP 43
EP 62
DI 10.1111/den.14061
EA JUL 2021
PG 20
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA YE4NK
UT WOS:000674845600001
PM 34115407
OA Bronze
DA 2026-07-24
ER

PT J
AU Fulco, I
   Erba, P
   Valeri, RC
   Vournakis, J
   Schaefer, DJ
AF Fulco, Ilario
   Erba, Paolo
   Valeri, Robert C.
   Vournakis, John
   Schaefer, Dirk J.
TI Poly-N-acetyl glucosamine nanofibers for negative-pressure wound
   therapies
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FIBERS; FOAM
AB The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p=0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.
C1 [Fulco, Ilario; Erba, Paolo; Schaefer, Dirk J.] Univ Basel Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Erba, Paolo] Univ Lausanne Hosp, Div Plast & Reconstruct Surg, CH-4031 Basel, Switzerland.
   [Valeri, Robert C.] Naval Blood Res Lab, Boston, MA USA.
   [Vournakis, John] Marine Polymer Technol Inc, Danvers, MA USA.
C3 University of Basel
RP Erba, P (通讯作者)，Univ Basel Hosp, Dept Plast Reconstruct & Aesthet Surg, CH-4031 Basel, Switzerland.
EM erbapaolo@hotmail.com
RI Fulco, Ilario/Y-3177-2019; Schaefer, Dirk/I-9806-2018
OI Fulco, Ilario/0000-0001-8672-439X; 
FU Marine Polymer Technologies Inc., Danvers, MA, USA
FX Source of Funding: This study was supported by a research contract from
   Marine Polymer Technologies Inc., Danvers, MA, USA to University
   Hospital Basel, Switzerland.
CR BERG W, 1990, LANCET, V335, P1445, DOI 10.1016/0140-6736(90)91459-N
   Cutler N R, 1993, Decubitus, V6, P22
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   van Lis MS, 2010, SPINAL CORD, V48, P92, DOI 10.1038/sc.2009.146
NR 17
TC 6
Z9 13
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2015
VL 23
IS 2
BP 197
EP 202
DI 10.1111/wrr.12273
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CK7YE
UT WOS:000356452000168
PM 25703411
DA 2026-07-24
ER

PT J
AU Van der Velde, M
   Hudson, DA
AF Van der Velde, M
   Hudson, DA
TI VADER (vacuum-assisted dermal recruitment) - A new method of wound
   closure
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE vacuum-assisted wound closure
ID SHOELACE TECHNIQUE; PRESSURE
AB Acute wounds which cannot be closed primarily are usually closed with a split skin graft However a split skin graft has both functional (where tendons are exposed) and esthetic sequelae (contour deformity, different skin in color band texture) A novel technique is described which allows delayed primary closure of either fasciotomy wounds or full-thickness defects after harvest of a free or pedicle flap The technique described combines the boot ace suture technique (which achieves wound closure by progressive suture tightening) with the VAC (vacuum-assisted closure) system (which reduces tissue edema, facilitating movement of tissue, and also reduces bacterial contamination of the wound). Twelve of 14 wounds (average width of wound after insertion and tightening of bootlace suture was 5 cm) were successfully closed after an average of 8 days (range, 4-23 days) in 11 patients (mean age, 45 years; range, 18-77 years) using this technique Of the 2 patients where the technique was not successful, one patient was noncompliant and the other developed wound-edge necrosis Other complications were self-limiting
   The combined use of 2 methods of wound management facilitates delayed primary wound closure.
C1 Univ Cape Town, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town
RP Hudson, DA (通讯作者)，Groote Schuur Hosp, Observ, H53 Old Main Bldg, ZA-7925 Cape Town, South Africa.
EM hudsond@uctgshi.uct.ac.za
CR Asgari MM, 2000, ANN PLAS SURG, V44, P225, DOI 10.1097/00000637-200044020-00017
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Dodenhoff RM, 1997, INJURY, V28, P593, DOI 10.1016/S0020-1383(97)00095-8
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NR 8
TC 15
Z9 27
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2005
VL 55
IS 6
BP 660
EP 664
DI 10.1097/01.sap.0000187181.59748.19
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 991QE
UT WOS:000233827700025
PM 16327471
DA 2026-07-24
ER

PT J
AU Yatsun, V
   Yatsun, O
AF Yatsun, Vladyslav
   Yatsun, Oleksandr
TI Detection and Successful Treatment of Gunshot Wound to the Femoral
   Artery and Vein Four Days Post-incident: A Case Study
SO MILITARY MEDICINE
LA English
DT Article
AB This case study presents the successful treatment of a 26-year-old male who experienced profuse bleeding from a gunshot wound to his thigh 4 days after the initial injury. The patient underwent surgery performed by a military vascular surgeon, during which previously undetected injuries to the femoral artery and vein were identified. The surgeon conducted a femoral artery alloprosthesis and sutured the damaged femoral vein. Following the surgery, the patient received post-operative conservative treatment and vacuum-assisted closure therapy, resulting in no complications or development of irreversible ischemic manifestation. The clinical case demonstrates the possible positive effects of placing an endovascular balloon in the main artery (more proximal lesion) for prolonged bleeding control without the use of a tourniquet. In this case, the role of the endovascular balloon was played by a hematoma. As a result, the lower extremity survived 4 days before the arterial blood flow reconstruction was done. Although such a model of bleeding control is absolutely unacceptable for planned specialized surgery or even military surgery at a medical assistance level of II-III, it may be considered as a lifesaving measure when surgical intervention is not immediately available.
C1 [Yatsun, Vladyslav] Natl Mil Med Clin Ctr MMCH, Vasc Surg Clin, Minist Def Ukraine, UA-02138 Kyiv, Ukraine.
   [Yatsun, Oleksandr] Ukrainian Red Cross, Emergency Response Team, UA-07301 Vyshgorod, Kyiv, Ukraine.
RP Yatsun, V (通讯作者)，Natl Mil Med Clin Ctr MMCH, Vasc Surg Clin, Minist Def Ukraine, UA-02138 Kyiv, Ukraine.
EM vyacun@gmail.com
OI Yatsun, Vladyslav/0009-0000-6320-5108
CR Blackbourne LH, 2012, J TRAUMA ACUTE CARE, V73, pS378, DOI 10.1097/TA.0b013e3182754900
   Blackbourne LH, 2012, J TRAUMA ACUTE CARE, V73, pS372, DOI 10.1097/TA.0b013e3182755662
   Drew B, 2020, Journal of Special Operations Medicine, V20, P144, DOI [10.55460/rbra-wmwv, DOI 10.55460/RBRA-WMWV, 10.55460/RBRA-WMWV]
   Eastridge BJ, 2012, J TRAUMA ACUTE CARE, V73, pS431, DOI 10.1097/TA.0b013e3182755dcc
   Eastridge BJ, 2011, J TRAUMA, V71, pS4, DOI 10.1097/TA.0b013e318221147b
   Mazuchowski EL, 2020, J TRAUMA ACUTE CARE, V88, P686, DOI 10.1097/TA.0000000000002610
NR 6
TC 0
Z9 2
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV-DEC
PY 2025
VL 190
IS 11-12
BP e2620
EP e2623
DI 10.1093/milmed/usae564
EA DEC 2024
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9JP5Y
UT WOS:001383426500001
PM 39722551
DA 2026-07-24
ER

PT J
AU Antonic, M
   Petrovic, R
   Miksic, NG
AF Antonic, Miha
   Petrovic, Rene
   Miksic, Nina Gorisek
TI THERMOACTIVE NITINOL CLIPS AS PRIMARY AND SECONDARY STERNAL CLOSURE
   AFTER CARDIAC SURGERY-FIRST EXPERIENCE IN SLOVENIA
SO ACTA CLINICA CROATICA
LA English
DT Article
DE Median sternotomy; Wound closure; Nitinol clips; Surgical wound
   infection; Cardiac surgery
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; FIXATION;
   INFECTIONS; THERAPY
AB Although there has been a trend towards minimally invasive and sternum-sparing procedures, median sternotomy is still a standard surgical approach in cardiac surgery. Many techniques and innovations for closure of sternal osteotomy have been developed with contradictory results. In this report, we present our first experience with the nitinol-made sternal closure system in the primary, as well as secondary closure of sternal osteotomy. A small series of 20 patients had their sternotomy closed with Flexigrip clips. In one case, the Flexigrip clips were used in secondary wound closure in a patient with deep sternal wound infection after full sternotomy and coronary bypass surgery. After 6-month follow-up, all patients were doing well with their sternums clinically stable and the sternotomy wounds completely healed. In conclusion, Flexigrip clips offered a stable alternative to steel wires in primary, as well as secondary sternal closure. Moreover, in secondary sternal closure, the thermoactive clips offered safety advantages over the standard wire cerclage technique because the need for dissection of the substernal adhesions could be avoided.
C1 [Antonic, Miha; Petrovic, Rene] Univ Med Ctr Maribor, Dept Cardiac Surg, Maribor, Slovenia.
   [Antonic, Miha; Miksic, Nina Gorisek] Univ Maribor, Fac Med, Maribor, Slovenia.
   [Miksic, Nina Gorisek] Univ Med Ctr Maribor, Dept Infect Dis & Febrile Condit, Maribor, Slovenia.
C3 University of Maribor; University of Maribor; University of Maribor
RP Antonic, M (通讯作者)，Univ Med Ctr Maribor, Ljubljanska Ulica 5, SI-2000 Maribor, Slovenia.
EM miha.antonic@guest.arnes.si
RI Petrovič, Rene/JDW-3858-2023
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NR 26
TC 2
Z9 3
U1 0
U2 1
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PD SEP
PY 2021
VL 60
IS 3
BP 435
EP 440
DI 10.20471/acc.2021.60.03.14
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZH4SP
UT WOS:000760930700010
PM 35282482
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kakagia, D
AF Kakagia, Despoina
TI How to Close a Limb Fasciotomy Wound: An Overview of Current Techniques
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE limb fasciotomy wound; open trauma; dermatotraction; negative pressure
   therapy; compartment syndrome; assisted wound closure
ID DELAYED PRIMARY CLOSURE; VACUUM-ASSISTED CLOSURE; LOOP SHOELACE
   TECHNIQUE; VISCOELASTIC PROPERTIES; SKIN DEFECTS; DEVICE; TRAUMA;
   DERMATOTRACTION; STRETCH
AB Early fasciotomy is the gold standard of prevention and treatment of compartment syndrome; however, the resulting wounds may significantly increase morbidity. To address the challenge of timely and safe closure of fasciotomy wounds, numerous methods have been described. A thorough search of medical databases PubMed/MEDLINE, ScienceDirect, SCOPUS, EMBASE, and Google Scholar was conducted for articles published between 1976 and 2013 using the search terms limb fasciotomy wound closure, open wound management, skin stretching, and fasciotomy complications. A total of 49 articles on technique descriptions, case reports of 2 or more patients, and of complications and comparative studies regarding limb fasciotomy wound closure were included. Details of the duration of treatment, advantages and disadvantages, direct cost, and complications were data extracted for each technique from the 49 studies included in this overview. Thorough knowledge of available techniques and their comparative advantages is essential for their clinical implementation, careful selection of patients, management of possible complications, decreased morbidity, and hospital recovery time and is also crucial for optimization of functional and aesthetic outcomes.
C1 [Kakagia, Despoina] Democritus Univ Thrace, Alexandroupolis, Greece.
C3 Democritus University of Thrace
RP Kakagia, D (通讯作者)，7 P Kirillou St, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
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NR 57
TC 17
Z9 25
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2015
VL 14
IS 3
SI SI
BP 268
EP 276
DI 10.1177/1534734614550310
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CT3MN
UT WOS:000362710900010
PM 25256284
DA 2026-07-24
ER

PT J
AU Rijkenhuizen, ABM
   van den Boom, R
   Landman, M
   Cornelissen, BPM
AF Rijkenhuizen, ABM
   van den Boom, R
   Landman, M
   Cornelissen, BPM
TI Can Vacuum assisted wound management enhance graft acceptance?
SO PFERDEHEILKUNDE
LA English
DT Article
DE surgery; traumatology; woundtreatment; skin grafting; vacuum assisted
ID SKIN-GRAFTS; CLOSURE; PRESSURE; THERAPY
AB Vacuum-assisted wound closure (VAC), a novel innovation in wound-care, has been proven to promote wound healing in human medicine and was recently also described for the treatment of a neck wound in a horse. It ensures adequate wound drainage, a moist wound-healing environment, increased rate of granulation tissue formation, improved blood flow and reduced bacterial count. The results of the application of VAC as a supportive therapy in skin grafting are encouraging in human patients with take rates of grafts above 90%. The question is whether these results can also be obtained in horses. This article reports the clinical application of VAC in combination with the Meek micrografting method in 2 equine patients. The VAC provided adequate wound drainage, good fixation of the graft to the recipient site, limited shear forces and allowed graft acceptance of at least 75% in both patients. Although no control studies were conducted, the clinical results suggest that vacuum-assisted closure stimulates the acceptance of split thickness grafts and accelerates wound healing and may become an essential part of wound treatment in the future.
C1 Univ Utrecht, Fac Vet Med, Dept Equine Sci, NL-3584 CM Utrecht, Netherlands.
C3 Utrecht University
RP Rijkenhuizen, ABM (通讯作者)，Univ Utrecht, Fac Vet Med, Dept Equine Sci, Yalelaan 12, NL-3584 CM Utrecht, Netherlands.
EM a.rijkenhuizen@vet.uu.nl
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NR 16
TC 16
Z9 17
U1 0
U2 12
PU HIPPIATRIKA VERLAG MBH
PI STUTTGART
PA POSTFACH 102251, 70018 STUTTGART, GERMANY
SN 0177-7726
J9 PFERDEHEILKUNDE
JI Pferdeheilkunde
PD SEP-OCT
PY 2005
VL 21
IS 5
BP 413
EP 418
DI 10.21836/PEM20050503
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 974PB
UT WOS:000232602800003
OA Bronze
DA 2026-07-24
ER

PT J
AU White, R
AF White, R.
TI Wound dressings and other topical treatment modalities in bioburden
   control
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dressing materials; bioburden; sequestration; chapter; Microbiology of
   Wounds
ID VACUUM-ASSISTED CLOSURE; HUMAN NEUTROPHIL ELASTASE; MANUKA HONEY;
   PSEUDOMONAS-AERUGINOSA; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY;
   STAPHYLOCOCCUS-AUREUS; BACTERIAL INVASION; OXYGEN-THERAPY; ULCERS
AB This is a chapter taken from the book Microbiology of Wounds, published by CRC Press in 2010. Reduction of wound bioburden has traditionally been achieved by the use of topical antimicrobial agents, such as bactericidal antiseptics or antibiotics. This has worked well for many years, however, concerns about toxicity and resistance have prompted research into other mechanisms. There are various means of removing bacteria from the wound, without recourse to chemical agents; for example, larvae (maggots) ingest bacteria, together with the devitalised tissue of the wound, while the control of exudate restricts the availability of free water, impeding the growth of water-loving bacteria. The discovery that some materials selectively adsorb, or sequester, bacteria has led to the development of bacteriostatic dressing materials, which do not rely on antiseptics for their action. These are designed to physically remove microorganisms, such as bacteria, from the wound, thus reducing bioburden. However, this still demands validation as a clinically relevant mechanism. Until that time, it remains a fascinating theoretical concept.
C1 Univ Worcester, Worcester, MA USA.
RP White, R (通讯作者)，Univ Worcester, Worcester, MA USA.
EM r.white@worc.ac.uk
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NR 134
TC 16
Z9 18
U1 0
U2 23
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2011
VL 20
IS 9
BP 431
EP 439
DI 10.12968/jowc.2011.20.9.431
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 931BQ
UT WOS:000303189600005
PM 22068142
DA 2026-07-24
ER

PT J
AU Shirakawa, M
   Isseroff, RR
AF Shirakawa, M
   Isseroff, RR
TI Topical negative pressure devices - Use for enhancement of healing
   chronic wounds
SO ARCHIVES OF DERMATOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL;
   CLINICAL-EXPERIENCE; SUBATMOSPHERIC PRESSURE; THERAPY; MANAGEMENT;
   DRESSINGS; ULCERS
AB Chronic wounds present a significant challenge, because there are few available treatment options for timely healing. Topical negative pressure devices, have been used in a number of different types of wounds, including chronic wounds. They are believed to hasten wound healing by (1) maintaining A moist environment, (2) removing wound exudates, (3) increasing local blood flow, (4) increasing granulation tissue formation, (5) applying mechanical pressure to promote wound closure, band (6) reducing bacterial loads in the wound. Multiple nonrandomized, noncontrolled studies have,reported that the use of these devices results in faster, healing times and more successful closures. Five small randomized, controlled trials have also shown favorable outcomes with the use of topical negative pressure devices compared with conventional treatment. Adverse effects include discomfort, pain, and excessive tissue growth into the dressing. Complications are limited if the device is used properly. In light of the current treatment options, topical negative pressure devices may be considered useful as adjuvant therapy for chronic wounds; however, there is inadequate definitive evidence that wound healing is substantially better with these devices than with traditional therapy.
C1 Univ Calif Davis, Sch Med, Dept Dermatol, Davis, CA 95616 USA.
   Sacromento Vet Affairs Med Ctr, Wound Healing Clin, Maher, CA USA.
C3 University of California System; University of California Davis
RP Isseroff, RR (通讯作者)，Univ Calif Davis, Sch Med, Dept Dermatol, TB 192,1 Shields Ave, Davis, CA 95616 USA.
EM rrisseroff@ucdavis.edu
RI Isseroff, Roslyn/HPH-5753-2023
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NR 32
TC 25
Z9 30
U1 0
U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-987X
EI 1538-3652
J9 ARCH DERMATOL
JI Arch. Dermatol.
PD NOV
PY 2005
VL 141
IS 11
BP 1449
EP 1453
DI 10.1001/archderm.141.11.1449
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 982SU
UT WOS:000233182700013
PM 16301393
DA 2026-07-24
ER

PT J
AU Valli, PV
   Mertens, J
   Kröger, A
   Gubler, C
   Gutschow, C
   Schneider, PM
   Bauerfeind, P
AF Valli, Piero V.
   Mertens, JoachimC.
   Kroger, Arne
   Gubler, Christoph
   Gutschow, Christian
   Schneider, Paul M.
   Bauerfeind, Peter
TI Stent-over-sponge (SOS): a novel technique complementing endosponge
   therapy for foregut leaks and perforations
SO ENDOSCOPY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKS
AB Background and study aims Endoluminal vacuum therapy (EVT) has evolved as a promising option for endoscopic treatment of foregut wall injuries in addition to the classic closure techniques using clips or stents. To improve vacuum force and maintain esophageal passage, we combined endosponge treatment with a partially covered self-expandable metal stent (stent-over-sponge; SOS).
   Patients and methods Twelve patients with infected upper gastrointestinal wall defects were treated with the SOS technique.
   Results Indications for SOS were anastomotic leakage after surgery (n = 11) and chronic foregut fistula (n = 1). SOS treatment was used as a first-line treatment in seven patients with a success rate of 71.4% (5/7) and as a second-line treatment after failed previous EVT treatment in five patients (success rate 80 %; 4/5). Overall, SOS treatment was successful in 75% of patients (9/12). No severe adverse events occurred.
   Conclusion SOS is an effective method to treat severely infected foregut wall defects in patients where EVT has failed, and also as a first-line treatment. Comparative prospective studies are needed to confirm our preliminary results.
C1 [Valli, Piero V.; Mertens, JoachimC.; Kroger, Arne; Gubler, Christoph; Bauerfeind, Peter] Univ Hosp Zurich, Div Gastroenterol & Hepatol, Zurich, Switzerland.
   [Gutschow, Christian; Schneider, Paul M.] Univ Hosp Zurich, Dept Visceral & Transplant Surg, Zurich, Switzerland.
   [Schneider, Paul M.] Hirslanden Med Ctr, Ctr Visceral Thorac & Specialized Tumor Surg, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Bauerfeind, P (通讯作者)，Univ Spital Zurich, Klin Gastroenterol & Hepatol, Ramistr 100, CH-8091 Zurich, Switzerland.
EM peter.bauerfeind@gmx.ch
RI ; Bauerfeind, Peter/AAV-2069-2020
OI Mertens, Joachim C/0000-0003-2007-0308; 
CR Dumonceau JM, 2015, ENDOSCOPY, V47, P1175, DOI 10.1055/s-0034-1393414
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   Gubler C, 2014, SCAND J GASTROENTERO, V49, P23, DOI 10.3109/00365521.2013.850735
   Kuehn F, 2017, SURG ENDOSC, V31, P3449, DOI 10.1007/s00464-016-5404-x
   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
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   Schneider PM, EUROPEAN MANUAL MED, V201, P263
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
NR 9
TC 44
Z9 49
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0013-726X
EI 1438-8812
J9 ENDOSCOPY
JI Endoscopy
PD FEB
PY 2018
VL 50
IS 2
BP 148
EP 153
DI 10.1055/s-0043-120442
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA FV1UF
UT WOS:000424349600018
PM 29186638
DA 2026-07-24
ER

PT J
AU Rexer, M
   Ditterich, D
   Rupprecht, H
AF Rexer, M
   Ditterich, D
   Rupprecht, H
TI VAC®-therapy in abdominal surgery - Experiences, limits and
   indications
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE VAC((R))-therapy; abdominal surgery; indications
ID VACUUM-ASSISTED CLOSURE; PACK TECHNIQUE; MANAGEMENT; FISTULA
AB Compared to other surgical disciplines the significance of V.A.C.(R)-therapy is rarely noticed in abdominal surgery. This may be due to uncertainty in defining clear indications or lack of technical know-how.
   Methods: We report on five selected septic cases in abdominal surgery without clearly defined indications for V.A.C.(R)-therapy (ischiorectal abscess, perforation in Crohn's disease, pelvic abscess due to perforation caused by rectal carcinoma, abdominal compartment syndrome, anastomotic leak after rectal resection).
   Results: Regarding the individual aspects of indication, V.A.C.(R)-therapy could be used successfully in the demonstrated cases. Under the palliative aspect, V.A.C.(R)-therapy on a malignant wound bed allowed an early treatment with chemotherapy.
   Discussion: According to the literature dealing with V.A.C.(R)-therapy, enterocutaneous fistulas, exposed viscera, enteral surfaces as well as malignancy in the wound bed are considered to be contraindications for the method. Reffering to our observations, these diagnoses should not be strictly regarded as contraindications. Elaboration of clear guidelines that point out clearly defined indications for V.A.C.(R)-therapy should be the goal for the future.
C1 Klinikum Furth, Chirurg Klin 1, D-90766 Furth, Germany.
RP Rexer, M (通讯作者)，Klinikum Furth, Chirurg Klin 1, Jakob Henle Str 1, D-90766 Furth, Germany.
EM martin.rexer@tiscali.de
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NR 13
TC 11
Z9 11
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S27
EP S32
DI 10.1055/s-2004-822640
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 826GF
UT WOS:000221816600009
PM 15168279
DA 2026-07-24
ER

PT J
AU Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
AF Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
TI Effects of different negative pressures on reduction of wounds in
   negative pressure dressings
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative pressure dressings; negative pressure therapy; negative
   pressure levels; animal study
ID VACUUM-ASSISTED CLOSURE; STRESS
AB Negative pressure dressings stimulate the healing of tissue-deficient wounds by applying continuous or intermittent negative pressure. This study was designed to determine the most effective negative pressure level for the reduction of the wound by using negative pressure dressings in animal studies. Fifty male Wister rats weighting 200-250 grams were used throughout the study. The animals were divided into five groups of ten animals each as follows: group 1: No negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. Group 2-5: 25, 50, 75 and 125 mmHg negative pressure and a closed dressing method using a polyurethane foam and an adhesive drape. The wounds were measured along the vertical and horizontal lengths of the body axis and the wound area was calculated. The reduction of the wound area was weaker in the group with a negative pressure of 25 mmHg, and similarly higher among the groups with negative pressures of 50, 75, or 125 mmHg. There were no significant differences in the reduction of the wound area among the latter three groups.
C1 Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan.
   Natl Disaster Med Ctr, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Isago, T (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
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NR 9
TC 44
Z9 54
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD AUG
PY 2003
VL 30
IS 8
BP 596
EP 601
DI 10.1111/j.1346-8138.2003.tb00441.x
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 714LY
UT WOS:000184916800003
PM 12928528
DA 2026-07-24
ER

PT J
AU Wotton, R
   Garner, M
   Salem, A
   Buderi, S
AF Wotton, Robin
   Garner, Megan
   Salem, Agni
   Buderi, Silviu
TI Is open window thoracostomy the only method to control infection in
   patients with an empyema following pulmonary resection for primary lung
   cancer?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Empyema; Lobectomy; Open window thoracostomy; Conservative management
ID MANAGEMENT
AB A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed: Is open window thoracostomy (OWT) the only method to control infection in patients with an empyema following pulmonary resection for primary lung cancer? Altogether 442 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Empyema following anatomical lung resection (excluding pneumonectomy) is an uncommon complication but one that remains a challenge to treat effectively. Chest tube thoracostomy and intravenous antibiotics remain the initial steps to management, but evidence is lacking with regard to the best ongoing strategy. Conservative options including chest cavity irrigation, postural drainage and vacuum-assisted closure have been attempted with some success, even in the presence of a broncho-pleural fistula. However, the very limited number of patients on which these various management strategies have been trialled on prevents recommendations and clear guidance being given.
C1 [Wotton, Robin; Garner, Megan; Salem, Agni] Liverpool Heart & Chest Hosp, Dept Thorac Surg, Liverpool L14 3PE, Merseyside, England.
   [Buderi, Silviu] Royal Brompton & Harefield, Dept Thorac Surg, London, England.
C3 Liverpool Heart & Chest Hospital; Royal Brompton Hospital
RP Wotton, R (通讯作者)，Liverpool Heart & Chest Hosp, Dept Thorac Surg, Liverpool L14 3PE, Merseyside, England.
EM robin.wotton@lhch.nhs.uk
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NR 10
TC 6
Z9 9
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2021
VL 32
IS 6
BP 928
EP 932
DI 10.1093/icvts/ivab009
EA FEB 2021
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA SS1AR
UT WOS:000661474500013
PM 33570150
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Grigoropoulou, VA
   Prassinos, NN
   Papazoglou, LG
   Galatos, AD
   Pourlis, AF
AF Grigoropoulou, Virginia A.
   Prassinos, Nikitas N.
   Papazoglou, Lysimachos G.
   Galatos, Apostolos D.
   Pourlis, Aris F.
TI Scrotal Flap for Closure of Perineal Skin Defects in Dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUNDS; ARTERIES; GRAFTS; TAIL
AB Objective To describe the use of a scrotal flap for covering perineal skin defects in dogs. Study Design Experimental study. Animals Male Beagles (n = 5). Methods A scrotal flap was created by making a U-shaped incision around the scrotum, with the base of the flap at its rostral border. Orchiectomy was performed through this incision and the scrotum was undermined from the underlying tissue. A small median longitudinal incision in the caudal aspect of the scrotum eliminated its curvature. A skin defect, comparable to the size of the scrotal flap, was created in the perineum extending from the caudal side of the scrotum toward the anus. The scrotal flap covered the defect and was sutured in place. Results By 57 days, all flaps had approximate to 27% necrosis on their caudal border. The necrotic area was surgically excised and the defect was covered completely again by the remaining healthy flap. One year after surgery, wound healing was normal and flap survival was complete, providing full coverage of the perineal skin defect. Conclusion A scrotal flap can be used to reconstruct perineal skin defects ventral to the anus.
C1 [Grigoropoulou, Virginia A.; Galatos, Apostolos D.] Univ Thessaly, Fac Vet Med, Surg Clin, GR-43100 Kardhitsa, Greece.
   [Prassinos, Nikitas N.; Papazoglou, Lysimachos G.] Aristotle Univ Thessaloniki, Fac Vet Med, Compan Anim Clin, GR-54006 Thessaloniki, Greece.
   [Pourlis, Aris F.] Univ Thessaly, Fac Vet Med, Dept Anat Histol & Embryol, GR-43100 Kardhitsa, Greece.
C3 University of Thessaly; Aristotle University of Thessaloniki; University
   of Thessaly
RP Grigoropoulou, VA (通讯作者)，Univ Thessaly, Fac Vet Med, Surg Clin, 224 Trikalon Str, GR-43100 Kardhitsa, Greece.
EM virginiagr78@gmail.com
RI ; Pourlis, Aris/AAF-2882-2019
OI PAPAZOGLOU, LYSIMACHOS/0000-0001-5471-4584; Pourlis,
   Aris/0000-0002-8168-2263
FU State Scholarships Foundation
FX Funded by the State Scholarships Foundation.
CR Bellah JR, 2006, VET CLIN N AM-SMALL, V36, P913, DOI 10.1016/j.cvsm.2006.04.002
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NR 25
TC 7
Z9 7
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
J9 VET SURG
JI Vet. Surg.
PD FEB
PY 2013
VL 42
IS 2
BP 186
EP 191
DI 10.1111/j.1532-950X.2012.00998.x
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 088WM
UT WOS:000314868500009
PM 22823187
DA 2026-07-24
ER

PT J
AU Hillis, LD
   Smith, PK
   Anderson, JL
   Bittl, JA
   Bridges, CR
   Byrne, JG
   Cigarroa, JE
   DiSesa, VJ
   Hiratzka, LF
   Hutter, AM
   Jessen, ME
   Keeley, EC
   Lahey, SJ
   Lange, RA
   London, MJ
   Mack, MJ
   Patel, MR
   Puskas, JD
   Sabik, JF
   Selnes, O
   Shahian, DM
   Trost, JC
   Winniford, MD
AF Hillis, L. David
   Smith, Peter K.
   Anderson, Jeffrey L.
   Bittl, John A.
   Bridges, Charles R.
   Byrne, John G.
   Cigarroa, Joaquin E.
   DiSesa, Verdi J.
   Hiratzka, Loren F.
   Hutter, Adolph M., Jr.
   Jessen, Michael E.
   Keeley, Ellen C.
   Lahey, Stephen J.
   Lange, Richard A.
   London, Martin J.
   Mack, Michael J.
   Patel, Manesh R.
   Puskas, John D.
   Sabik, Joseph F.
   Selnes, Ola
   Shahian, David M.
   Trost, Jeffrey C.
   Winniford, Michael D.
TI 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery:
   Executive Summary A Report of the American College of Cardiology
   Foundation/American Heart Association Task Force on Practice Guidelines
SO CIRCULATION
LA English
DT Article
DE AHA Scientific Statements; acute coronary syndromes; anticoagulants;
   antiplatelet agents; arrhythmias, cardiac; coronary angiography;
   coronary artery revascularization; interventions: stents; drug therapy;
   heart diseases; myocardial revascularization; platelet aggregation
   inhibitor; ultrasound
ID ACUTE MYOCARDIAL-INFARCTION; LONG-TERM SURVIVAL; VACUUM-ASSISTED
   CLOSURE; PREOPERATIVE STATIN THERAPY; ACUTE-RENAL-FAILURE;
   TRANSMYOCARDIAL LASER REVASCULARIZATION; DRUG-ELUTING STENTS; HIGH-RISK
   PATIENTS; INTRAOPERATIVE TRANSESOPHAGEAL ECHOCARDIOGRAPHY; MODERATE
   AORTIC-STENOSIS
AB The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease. When properly applied, expert analysis of available data on the benefits and risks of these therapies and procedures can improve the quality of care, optimize patient outcomes, and favorably affect costs by focusing resources on the most effective strategies. An organized and directed approach to a thorough review of evidence has resulted in the production of clinical practice guidelines that assist physicians in selecting the best management strategy for an individual patient. Moreover, clinical practice guidelines can provide a foundation for other applications, such as performance measures, appropriate use criteria, and both quality improvement and clinical decision support tools.
C1 [Hillis, L. David; Lange, Richard A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
   [Smith, Peter K.] Duke Univ, Med Ctr Private Diagnost Clin, Durham, NC 27706 USA.
   [Bridges, Charles R.] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA.
   [Byrne, John G.] Vanderbilt Univ, Med Ctr Div Cardiac Surg, Nashville, TN 37235 USA.
   [Cigarroa, Joaquin E.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
   [DiSesa, Verdi J.] Johns Hopkins Univ Hosp, Div Cardiac Surg, Baltimore, MD 21287 USA.
   [Hutter, Adolph M., Jr.; Shahian, David M.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Keeley, Ellen C.] Univ Virginia, Charlottesville, VA 22903 USA.
   [Lahey, Stephen J.] Univ Connecticut, Storrs, CT USA.
   [London, Martin J.] Univ Calif San Francisco, Vet Affairs Med Ctr, San Francisco, CA 94143 USA.
   [Mack, Michael J.] Heart Hosp Baylor Plano Cardiovasc Surg, Plano, TX USA.
   [Patel, Manesh R.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
   [Puskas, John D.] Emory Univ Emory Healthcare, Atlanta, GA USA.
   [Sabik, Joseph F.] Cleveland Clin Fdn, Cleveland, OH USA.
   [Selnes, Ola] Johns Hopkins Univ Hosp, Dept Neurol, Baltimore, MD 21287 USA.
   [Trost, Jeffrey C.] Johns Hopkins Sch Med, Baltimore, MD USA.
   [Winniford, Michael D.] Univ Mississippi, Med Ctr, University, MS 38677 USA.
C3 University of Texas System; University of Texas at San Antonio; Duke
   University; University of Pennsylvania; Vanderbilt University; Oregon
   Health & Science University; Johns Hopkins University; Johns Hopkins
   Medicine; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; University of Virginia; University of
   Connecticut; University of California System; University of California
   San Francisco; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Duke University; Cleveland Clinic Foundation;
   Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; University of Mississippi Medical
   Center; University of Mississippi
RP Hillis, LD (通讯作者)，Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
RI Lange, Richard/AAM-9594-2021; Patel, Manesh/AAC-5385-2019
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NR 494
TC 333
Z9 395
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD DEC 6
PY 2011
VL 124
IS 23
BP 2610
EP 2642
DI 10.1161/CIR.0b013e31823b5fee
PG 33
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 863QW
UT WOS:000298183300023
PM 22064600
OA Bronze
DA 2026-07-24
ER

PT J
AU Cekici, SG
   Ulukent, SC
   Yildirim, GY
   Esmer, AC
   Akca, A
   Kublay, A
AF Cekici, S. Guler
   Ulukent, S. C.
   Yildirim, G. Yetkin
   Esmer, A. Corbacioglu
   Akca, A.
   Kublay, A.
TI A case of spontaneous bladder rupture following vaginal delivery in a
   mutilated woman
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Female genital mutilation; Genitourinary system injuries; Spontaneous
   bladder rupture
AB Background: Female genital mutilation/cutting (FGM/C) is applied to more than 130 million women in the world with long-term complications of pain, dyspareunia, difficulty in urination, recurrent urinary tract infection, vesicovaginal fistula, and obstetric morbidities. The authors present a case of spontaneous bladder rupture following vaginal delivery in a genital mutilated pregnant woman, which has not been reported in the literature previously. Case Report: A 31-year old age primigravid woman presented on postpartum 6th day with abdominal distention, ileus, dyspnea, and acute renal failure. After physical and radiological examination with laboratory analysis the initial diagnosis was intra-abdominal sepsis. During laparotomy, disseminated abscess formation and massive urinary leakage from ruptured bladder wall was observed. After bladder repair, open abdomen procedure was performed to control abdominal infection. Vacuum-assisted closure therapy was applied as a temporary abdominal closure method. The patient was discharged from the hospital with no complications on the 14th day. Conclusion: This case report shows that genital mutilation can lead to genitourinary system injuries and is one of the etiologic factors of spontaneous bladder rupture during vaginal delivery.
C1 [Cekici, S. Guler; Yildirim, G. Yetkin; Akca, A.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Turgut Ozal Cad 1, TR-34303 Istanbul, Turkey.
   [Ulukent, S. C.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Esmer, A. Corbacioglu] Kanuni Sultan Suleyman Training & Res Hosp, Dept Maternal Fetal Med, Istanbul, Turkey.
   [Kublay, A.] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gyneccol Oncol, Istanbul, Turkey.
C3 Istanbul Kanuni Sultan Suleyman Training & Research Hospital; Istanbul
   Kanuni Sultan Suleyman Training & Research Hospital; Istanbul Kanuni
   Sultan Suleyman Training & Research Hospital; Istanbul Kanuni Sultan
   Suleyman Training & Research Hospital
RP Cekici, SG (通讯作者)，Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Turgut Ozal Cad 1, TR-34303 Istanbul, Turkey.
EM sebileguler@gmail.com
RI ULUKENT, SUAT CAN/A-7012-2018; Güler Çekiç, Sebile/KGM-4777-2024
OI ULUKENT, SUAT CAN/0000-0002-1714-847X; Güler Çekiç,
   Sebile/0000-0002-1632-1170
CR Banks E, 2006, LANCET, V367, P1835, DOI 10.1016/S0140-6736(06)68805-3
   Berg RC, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006316
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   Png KS, 2008, SINGAP MED J, V49, pE327
   Wandabwa Julius, 2004, Afr Health Sci, V4, P138
NR 8
TC 1
Z9 1
U1 0
U2 2
PU I R O G CANADA, INC
PI MONTREAL
PA 4900 COTE ST-LUC, APT#212, MONTREAL, QUEBEC H3W 2H3, CANADA
SN 0390-6663
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PY 2017
VL 44
IS 6
BP 941
EP 943
DI 10.12891/eeog3791.2017
PG 3
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FZ5AQ
UT WOS:000427604100025
DA 2026-07-24
ER

PT J
AU Anderson, O
   Putnis, A
   Bhardwaj, R
   Ho-Asjoe, M
   Carapeti, E
   Williams, AB
   George, ML
AF Anderson, O.
   Putnis, A.
   Bhardwaj, R.
   Ho-Asjoe, M.
   Carapeti, E.
   Williams, A. B.
   George, M. L.
TI Short- and long-term outcome of laparostomy following intra-abdominal
   sepsis
SO COLORECTAL DISEASE
LA English
DT Article
DE Drainage; intestinal fistula; postoperative complications; abdominal
   wall; reconstructive surgical procedures; peritonitis; vacuum; APACHE
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL DEFECTS; OPEN MANAGEMENT; SEPTIC
   ABDOMEN; APACHE-II; MESH; INFECTION; ZIPPER; WOUNDS; REPAIR
AB Aim
   This study reports the short- and long-term outcomes of laparostomy for intra-abdominal sepsis.
   Method
   Twenty-nine sequential patients with intra-abdominal sepsis treated with a laparostomy over 6 years were included.
   Results
   The median age of the patients was 51 years, postoperative intensive care unit stay was 8 days, postoperative length of hospital stay was 87 days and follow up was 2 years. The expected mortality of 25% was insignificantly different from the observed mortality of 33% (P = 0.35). Seven per cent of patients required percutaneous drainage of intra-abdominal collections. An enterocutaneous fistula developed in 31% of all patients and in 15% of those treated with vacuum dressings. Component-separation fascial reconstruction was successful and uncomplicated in 83% of recipients compared with 25% of mesh repairs.
   Conclusion
   Laparostomy does not significantly reduce mortality from the expected rate and commits the patient to a prolonged recovery with a high risk of enterocutaneous fistulation. Component-separation fascial reconstruction has a better outcome than mesh repair.
C1 [Anderson, O.; Putnis, A.; Bhardwaj, R.; Carapeti, E.; Williams, A. B.; George, M. L.] St Thomas Hosp, Dept Colorectal Surg, London, England.
   [Ho-Asjoe, M.] St Thomas Hosp, Dept Plast Surg, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust; Guy's & St Thomas' NHS
   Foundation Trust
RP Anderson, O (通讯作者)，Univ London Imperial Coll Sci Technol & Med, Clin Safety Res Unit, Ctr Patient Safety & Serv Qual, St Marys Hosp, Room 1064-5,10th Floor QEQM Bldg, London W2 1NY, England.
EM oliver.anderson@imperial.ac.uk
RI /B-1434-2010; Williams, Andrew/AAU-4856-2020
CR Bailey CMH, 2000, DIS COLON RECTUM, V43, P25, DOI 10.1007/BF02237239
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NR 32
TC 12
Z9 15
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD FEB
PY 2011
VL 13
IS 2
BP e20
EP e32
DI 10.1111/j.1463-1318.2010.02441.x
PG 13
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 709XC
UT WOS:000286473700002
PM 21040361
DA 2026-07-24
ER

PT J
AU Felmerer, G
   Muehlberger, T
   von Rautenfeld, DB
   Vogt, PM
AF Felmerer, G
   Muehlberger, T
   von Rautenfeld, DB
   Vogt, PM
TI The lymphatic system of the deep inferior epigastric artery perforator
   flap: an anatomical study
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 5th European-Federation-of-Societies-for-Microsurgery Conference
CY JUN 01-04, 2000
CL COIMBRA, PORTUGAL
SP European Federat Societies Microsurg
DE deep inferior epigastric perforator flap; anatomy; lymphatic collectors;
   flap oedema
ID VACUUM-ASSISTED CLOSURE; BREAST RECONSTRUCTION; WOUND CONTROL; HUMAN
   SKIN
AB The anatomical basis of the lymphatic system of the deep inferior epigastric perforator (DIEP) flap was studied in 24 abdominoplasty specimens and in three fresh cadavers. Methylene (n = 4), patent (n = 4) and Turnbull's (n = 8) blue were compared by injecting the dye intradermally. To facilitate staining, two different types of vacuum technique were used: a vacuum chamber (n = 4) and the vacuum-assisted method (n = 4). The lymphatic collectors were dissected, and embedded in paraffin for histological investigation. The most useful dye was Turnbull's blue. The vacuum had no effect on the distribution of the dye. Manual injection showed three parallel superficial collectors situated directly under the skin. Turnbull's blue was also injected into the rectus fascia to demonstrate the collectors of the deep abdominal structures. They run horizontally, and perforate the fascia to run with the inferior epigastric artery. Care should be taken when dissecting the pedicle, or removing the epithelium, to avoid destroying the lymphatic system of the flap. (C) 2002 The British Association of Plastic Surgeons.
C1 Hannover Med Sch, Zentrum Schwerbrandverletzte, Klin Plast Hand & Wiederherstellungschirurg, D-30659 Hannover, Germany.
   Hannover Med Sch, Inst Funktionelle & Angew Anat, D-30623 Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School
RI Vogt, Peter/AAL-1332-2020
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NR 23
TC 24
Z9 26
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD JUN
PY 2002
VL 55
IS 4
BP 335
EP 339
DI 10.1054/bjps.2002.3830
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 577NN
UT WOS:000177067900012
PM 12160541
OA Bronze
DA 2026-07-24
ER

PT J
AU Daneste, H
   Boukani, LM
   Ramezani, N
   Asadi, F
   Zaidan, HK
   Sadeghzade, A
   Ehsannia, M
   Azarashk, A
   Gholizadeh, N
AF Daneste, Hossein
   Boukani, Linda Mohammadzadeh
   Ramezani, Narges
   Asadi, Fatemeh
   Zaidan, Haider Kamil
   Sadeghzade, Azita
   Ehsannia, Maedeh
   Azarashk, Ali
   Gholizadeh, Nasim
TI Combination therapy along with mesenchymal stem cells in wound healing;
   the state of the art
SO ADVANCES IN MEDICAL SCIENCES
LA English
DT Review
DE Mesenchymal stem cells (MSCs); Wound healing; Regenerative medicine;
   Wound regeneration; Cell therapy
ID VACUUM-ASSISTED CLOSURE; GREEN TEA; EPIGALLOCATECHIN GALLATE; STROMAL
   CELLS; VITAMIN-C; DIFFERENTIATION; PROLIFERATION; EXPRESSION;
   INFLAMMATION; MODULATION
AB Mesenchymal stem cells (MSCs) are being increasingly used in various therapeutic applications including skin tissue repair and wound healing. The positive effects of the MSCs therapy are largely elicited by immunomo-dulation, increasing angiogenesis, supporting extracellular matrix (ECM) and thus favoring skin structure. However, the therapeutic competences of MSC-based therapies are somewhat hindered by their apparent modest clinical merits, conferring the need for methods that would rise the efficacy of such therapies. A plethora of reports have shown that therapeutic properties of MSCs could be enhanced with other strategies and compounds like biomaterial and platelet-rich plasma (PRP) to target key possessions of MSCs and properties of adjacent tissues concurrently. Manipulation of cellular stress-response mechanisms to improve cell resistance to oxidative stress prior to or during MSC injection could also improve therapeutic efficacy of MSCs. In the current review, we shed light on the recent advances in MSCs combination therapy with other ingredients and procedures to sustain MSCs-mediated effects in wound healing.
C1 [Daneste, Hossein] Shiraz Univ Med Sci, Sch Dent, Dept Oral & Maxillofacial Surg, Shiraz, Iran.
   [Boukani, Linda Mohammadzadeh] Tabriz Univ Med Sci, Student Res Comm, Fac Med, Tabriz, Iran.
   [Ramezani, Narges] Islamic Azad Univ, Dept Biol, Damghan Branch, Damghan, Iran.
   [Asadi, Fatemeh] Islamic Azad Univ, Dept Biol, Izeh Branch, Izeh, Iran.
   [Zaidan, Haider Kamil] Al Mustaqbal Univ Coll, Dept Med Labs Tech, Hillah, Babylon, Iraq.
   [Sadeghzade, Azita] Shiraz Univ Med Sci, Sch Dent, Dept Oral & Maxillofacial Med, Shiraz, Iran.
   [Ehsannia, Maedeh] Islamic Azad Univ, Fac Basic Sci, Tehran East Branch, Tehran, Iran.
   [Azarashk, Ali] Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmaceut, Sari, Mazandaran, Iran.
   [Gholizadeh, Nasim] Mazandaran Univ Med Sci, Fac Med, Dept Dermatol, Valie Asr Blvd, Sari, Mazandaran, Iran.
C3 Shiraz University of Medical Science; Tabriz University of Medical
   Science; Islamic Azad University; Islamic Azad University; Al-Mustaqbal
   University College; Shiraz University of Medical Science; Islamic Azad
   University; Mazandaran University of Medical Sciences; Mazandaran
   University of Medical Sciences
RP Azarashk, A (通讯作者)，Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmaceut, Sari, Mazandaran, Iran.; Gholizadeh, N (通讯作者)，Mazandaran Univ Med Sci, Fac Med, Dept Dermatol, Valie Asr Blvd, Sari, Mazandaran, Iran.
EM Ali.azarashk@gmail.com; nasimg19891989@gmail.com
RI /AAW-4156-2020; Zaidan, Haider/GQG-9696-2022; Asadi,
   fatemeh/JRX-4376-2023; Sadeghzadeh, Azita/AAS-1745-2021; Gholizadeh,
   Nasim/CAF-7363-2022
OI Asadi, fatemeh/0000-0003-0126-7818; Sadeghzadeh,
   Azita/0000-0002-2601-4254; Gholizadeh, Nasim/0000-0002-7234-270X
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   Zhou Y, 2021, STEM CELL RES THER, V12, DOI 10.1186/s13287-021-02287-9
   Zhu J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107339
NR 108
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER URBAN & PARTNER SP Z O O
PI WROCLAW
PA UL MIGDALOWA 4, LOK 59, WROCLAW, 02-796, POLAND
SN 1896-1126
EI 1898-4002
J9 ADV MED SCI-POLAND
JI Adv. Med. Sci.
PD SEP
PY 2023
VL 68
IS 2
BP 441
EP 449
DI 10.1016/j.advms.2023.10.006
EA NOV 2023
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA Y9VL4
UT WOS:001108663700001
PM 37924749
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Viciriuc, EE
   Ludusanu, A
   Tanevski, A
   Corlade-Andrei, M
   Peiu, SN
   Dragomir, RA
   Vintila, D
   Stan, CI
   Balan, G
AF Ciuntu, Bogdan Mihnea
   Viciriuc, Edwina-Elena
   Ludusanu, Andreea
   Tanevski, Adelina
   Corlade-Andrei, Mihaela
   Peiu, Sorin Nicolae
   Dragomir, Raluca Alina
   Vintila, Dan
   Stan, Cristinel Ionel
   Balan, Gheorghe
TI Upper Esophageal Perforation with Cervico-Mediastinal Extension
   Successfully Treated with Endoluminal Vacuum Therapy: A Case Report
   Highlighting Inflammatory Marker Dynamics
SO LIFE-BASEL
LA English
DT Article
DE cervicomediastinitis; cervico-mediastinal abscess; cervical esophagus;
   cervical esophageal perforation; EVAC; deep neck infection; tracheostomy
ID COMPLICATION; MANAGEMENT; DEFECTS
AB Background: Upper esophageal perforations are life-threatening conditions associated with a high risk of mediastinitis, sepsis, and multiorgan failure. Standard management often requires extensive surgical intervention, which carries substantial morbidity. Methods: We report the case of a 56-year-old male with an iatrogenic cervical esophageal perforation complicated by cervicomediastinal abscess formation. Due to anatomical constraints preventing standard endoluminal approaches, a hybrid organ-preserving strategy was employed, consisting of surgical drainage combined with an externally adapted vacuum-assisted closure (VAC) system applied adjacent to the esophageal defect. Results: The patient demonstrated progressive clinical improvement without the need for esophageal diversion or major reconstructive surgery. Inflammatory markers were monitored serially and showed a downward trend, serving as adjunctive indicators of treatment response. The esophageal defect healed successfully, was confirmed radiologically, and no treatment-related complications were observed. Conclusions: This case suggests that externally adapted VAC therapy may represent a potential organ-preserving option in selected patients with complex cervical esophageal perforations when conventional techniques are not feasible. Further studies are required to validate this approach.
C1 [Ciuntu, Bogdan Mihnea; Tanevski, Adelina; Vintila, Dan] Grigore T Popa Univ Med & Pharm Iasi, Dept Gen Surg, Iasi 700115, Romania.
   [Viciriuc, Edwina-Elena; Dragomir, Raluca Alina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania.
   [Ludusanu, Andreea; Stan, Cristinel Ionel] Grigore T Popa Univ Med & Pharm Iasi, Dept Morphofunct Sci Anat 1, Iasi 700115, Romania.
   [Corlade-Andrei, Mihaela] Grigore T Popa Univ Med & Pharm Iasi, Dept Emergency Med, Surg 2, Iasi 700115, Romania.
   [Peiu, Sorin Nicolae] Grigore T Popa Univ Med & Pharm Iasi, Dept Vasc Surg, Iasi 700115, Romania.
   [Balan, Gheorghe] Grigore T Popa Univ Med & Pharm Iasi, Dept Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Grigore T Popa University of
   Medicine & Pharmacy
RP Viciriuc, EE (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi 700115, Romania.; Ludusanu, A (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Dept Morphofunct Sci Anat 1, Iasi 700115, Romania.
EM bogdan-mihnea.ciuntu@umfiasi.ro; edwinaviciriuc@yahoo.com;
   andreea.ludusanu@umfiasi.ro; papancea.adelina@umfiasi.ro;
   mihaela.corlade2@umfiasi.ro; sorin-nicolae.peiu@umfiasi.ro;
   raluca.dragomir@umfiasi.ro; dan.vintila@umfiasi.ro;
   cristinel.stan@umfiasi.ro; gheorghe-g-balan@umfiasi.ro
RI Stan, Cristinel/AAL-5618-2020; Ciuntu, Bogdan/MTF-9477-2025; Dragomir,
   Raluca Alina/AAV-7080-2020; Tanevski, Adelina/LUZ-8095-2024;
   Corlade-Andrei, Mihaela/HGB-3725-2022
OI Ludușanu, Andreea/0009-0003-1785-5785
CR Ardila CM, 2025, J CLIN MED, V14, DOI 10.3390/jcm14092881
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NR 23
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD APR 10
PY 2026
VL 16
IS 4
AR 639
DI 10.3390/life16040639
EA APR 2026
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA HC3MB
UT WOS:001750671500001
PM 42073449
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, X
   Zhang, YX
   Ng, SKH
   Zhang, Z
   Pu, ZM
   Yang, HL
   Min, PR
AF Wang, Xin
   Zhang, Yixin
   Ng, Sally Kiu-Huen
   Zhang, Zheng
   Pu, ZheMing
   Yang, Huilin
   Min, PeiRu
TI Using Modified Skin-Stretching Technique as an Alternative Solution for
   the Closure of Moderate and Extensive Skin Defects
SO REJUVENATION RESEARCH
LA English
DT Article
DE skin-stretching technique; skin defects; mechanical creep; primary
   closure
ID VACUUM-ASSISTED CLOSURE; TISSUE EXPANSION; SOFT-TISSUE; RECONSTRUCTION;
   FLAPS; OUTCOMES; GRAFTS; SYSTEM; DEVICE; BODY
AB External skin-stretching devices have been developed and used for wound closure since 1970s. Devices such as Miami STAR, SureClosure, TopClosure, and WiseBand have their own advantages and disadvantages. The modified external skin-stretching technique of this case series study has the advantage to improve tension distribution and simplified the application. Between January 2014 and June 2017, 20 patients were treated with the modified external skin-stretching device for the closure of the skin defects of the trunk (n = 6) and extremities (n = 14). Skin defects ranged from 8 x 5 to 19 x 16 cm achieved primary closure with the utilization of the modified skin-stretching device without major complications. Subsequent minor revisions were performed under local anesthesia between 6 and 12 months postoperatively. The modified skin-stretching device utilized biomechanical properties and mechanical creep of skin tissue to achieve a reliable and effective primary closure for moderate to extensive skin defects. Therefore, this modified external skin-stretching technique provided, in the appropriate setting, an effective alternative to skin grafts or free flaps.
C1 [Wang, Xin; Yang, Huilin] Soochow Univ, Dept Orthoped Surg, Affiliated Hosp 1, Suzhou, Peoples R China.
   [Zhang, Yixin; Zhang, Zheng; Pu, ZheMing; Min, PeiRu] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China.
   [Ng, Sally Kiu-Huen] Austin Hosp, Dept Plast Surg, Melbourne, Vic, Australia.
C3 Soochow University - China; Shanghai Jiao Tong University; Florey
   Institute of Neuroscience & Mental Health; Howard Florey Institute
   Affiliates
RP Yang, HL (通讯作者)，Soochow Univ, Dept Orthoped Surg, Affiliated Hosp 1, Suzhou, Peoples R China.; Min, PR (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China.
EM suzhouspine@163.com; aru_ren@msn.com
RI Ng, Sally/AAU-2796-2021; MIN, PEIRU/JBI-9763-2023
OI MIN, PEIRU/0000-0001-8279-8797
FU National Natural Science Foundation of China [81801918, 81772098]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81801918 and No. 81772098).
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NR 40
TC 5
Z9 5
U1 0
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD DEC 1
PY 2021
VL 24
IS 6
BP 407
EP 416
DI 10.1089/rej.2020.2389
EA NOV 2021
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA XQ4DU
UT WOS:000719852400001
PM 34714135
DA 2026-07-24
ER

PT J
AU Iesari, S
   Lai, Q
   Rughetti, A
   Dell'Orso, L
   Clemente, K
   Famulari, A
   Pisani, F
   Favi, E
AF Iesari, Samuele
   Lai, Quirino
   Rughetti, Anna
   Dell'Orso, Luigi
   Clemente, Katia
   Famulari, Antonio
   Pisani, Francesco
   Favi, Evaldo
TI Infected Nonhealing Wound in a Kidney Transplant Recipient: Successful
   Treatment With Topical Homologous Platelet-Rich Gel
SO EXPERIMENTAL AND CLINICAL TRANSPLANTATION
LA English
DT Article
DE Immunosuppression; Platelets; Surgical site infection; Transplant; Wound
   healing
ID PLASMA
AB Impaired would healing is a known adverse effect of chronic immunosuppression. Solid-organ transplant recipients undergoing major abdominal surgery have an increased risk of wound-related complications compared with the general population. In this subset of patients, surgical site infections and wound dehiscence must be aggressively treated to avoid sepsis, graft loss, and death.
   Recently, topical application of platelet-rich plasma has been proposed as an alternative therapeutic option to enhance wound healing in difficult cases. Unfortunately, randomized controlled trials evaluating the efficacy of platelet-rich plasma compared with standard or advanced wound management are lacking, and the literature mostly refers to anecdotal reports in patients with no evidence of wound infection.
   This report documents a kidney transplant recipient who experienced spontaneous bladder rupture because of gangrenous cystitis. After an exploratory laparotomy and bladder repair, the patient developed a deep surgical site infection by multidrug resistant Acinetobacter baumannii and extensive wound dehiscence. Advanced wound management and vacuum-assisted closure therapy were ineffective. Topical homologous platelet-rich gel was used resulting in significant wound healing, without infections or immunologic complications.
C1 [Iesari, Samuele; Lai, Quirino; Clemente, Katia; Famulari, Antonio; Pisani, Francesco] Univ Aquila, Dept Surg, Organ Transplantat, Via Vetoio 1, I-67100 Laquila, Italy.
   [Rughetti, Anna; Dell'Orso, Luigi] Immunotransfus Med PO San Salvatore, Laquila, Italy.
   [Favi, Evaldo] Royal London Hosp, Transplant & Vasc Access Renal Dept, London, England.
C3 University of L'Aquila; Barts Health NHS Trust; Royal London Hospital
RP Iesari, S (通讯作者)，Univ Aquila, Dept Surg, Organ Transplantat, Via Vetoio 1, I-67100 Laquila, Italy.
EM samuele.iesari@gmail.com
RI Iesari, Samuele/B-9541-2016; Favi, Evaldo/R-3423-2016; Pisani,
   Francesco/ABH-8545-2020; LAI, Quirino/H-2906-2019
OI Iesari, Samuele/0000-0002-6918-945X; Favi, Evaldo/0000-0001-6465-428X;
   LAI, Quirino/0000-0003-1487-3235
CR Anitua E, 2008, J BIOMED MATER RES B, V84B, P415, DOI 10.1002/jbm.b.30886
   Carter Marissa J, 2011, Eplasty, V11, pe38
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   Tang YQ, 2002, INFECT IMMUN, V70, P6524, DOI 10.1128/IAI.70.12.6524-6533.2002
NR 8
TC 5
Z9 6
U1 0
U2 6
PU BASKENT UNIV
PI ANKARA
PA TASKENT CADDESI NO 77, KAT 4, BAHCELIEVLER, ANKARA, 06490, TURKEY
SN 1304-0855
J9 EXP CLIN TRANSPLANT
JI Exp. Clin. Transplant.
PD APR
PY 2017
VL 15
IS 2
BP 222
EP 225
DI 10.6002/ect.2014.0236
PG 4
WC Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation
GA EW9AL
UT WOS:000402809100016
PM 26101881
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Niu, BB
   Xu, JJ
   Li, JA
   Zhu, LD
AF Niu, Bei-bei
   Xu, Jing-jing
   Li, Ji-an
   Zhu, Ling-dong
TI Case report: Cervical suppurative lymphadenitis caused by burkholderia
   multivorans in a healthy child
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Cervical suppurative lymphadenitis; Burkholderia multivorans; Healthy
   child; Precise diagnosis; Granulomatous inflammation
AB BackgroundCervical suppurative lymphadenitis in children is commonly caused by Staphylococcus aureus or Streptococcus pyogenes. However, cases caused by Burkholderia multivorans (BM) are rare. The clinical presentation lacks specificity, making it difficult for clinicians to recognize, which may delay diagnosis and treatment.Case presentationWe report a case of a 5-year-old boy admitted with recurrent fever and neck swelling. Initial treatment with meropenem and linezolid was ineffective, and symptoms persisted after 24 days of conservative therapy. Aspiration of pus yielded negative culture results. Definitive diagnosis was achieved through surgical biopsy of cervical lymph nodes, pathological examination, and metagenomic next-generation sequencing (mNGS), which identified BM as the causative pathogen. The patient was successfully treated with a combination of trimethoprim-sulfamethoxazole and meropenem. The cervical lesion exhibited granulomatous inflammation and was managed with adjunctive vacuum-assisted closure (VAC) therapy, resulting in complete wound healing without recurrence.ConclusionsThis study aims to raise awareness among all specialists about BM as a potential causative agent in cervical suppurative lymphadenitis. Early recognition and timely intervention can reduce misdiagnosis and missed diagnoses, improving patient outcomes.
C1 [Niu, Bei-bei; Xu, Jing-jing; Zhu, Ling-dong] Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Dept Plast & Burn Surg, Jingshi St 23976, Jinan 250000, Shandong, Peoples R China.
   [Li, Ji-an] Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Infect Dis Dept, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Zhu, LD (通讯作者)，Shandong Univ, Jinan Childrens Hosp, Childrens Hosp, Dept Plast & Burn Surg, Jingshi St 23976, Jinan 250000, Shandong, Peoples R China.
EM zhuld@etyy.com
OI Niu, Beibei/0009-0003-2104-2728
FU Natural Science Foundation of Shandong Province
FX Special thanks to all authors who contributed to the research.
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NR 17
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD MAY 8
PY 2025
VL 25
IS 1
AR 678
DI 10.1186/s12879-025-11033-y
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 2KX7H
UT WOS:001485103400006
PM 40340931
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dougher, MC
   Cartron, A
   Scott, J
   Bayerl, MG
   Helm, M
AF Dougher, Meaghan C.
   Cartron, Alexander
   Scott, Jennifer
   Bayerl, Michael G.
   Helm, Matthew
TI Primary Cutaneous Anaplastic Large Cell Lymphoma With Rare
   Extracutaneous Disseminated Disease: A Case Report
SO AMERICAN JOURNAL OF DERMATOPATHOLOGY
LA English
DT Article
DE cutaneous; lymphoma; large cell; anaplastic
AB Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a CD30+ lymphoproliferative disorder with generally favorable outcomes and infrequent extracutaneous spread, usually limited to local lymph nodes. However, there may be extensive histologic overlap with more aggressive CD30+ lymphomas, such as large cell transformation of mycosis fungoides or secondary skin involvement by anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma. Definitive diagnosis relies on clinicopathologic correlation. We report on a 26-year-old woman who presented to our institution with progressive lower extremity wounds for several months, previously treated with antibiotics and vacuum-assisted closure dressings. Consultation with dermatology and 2 separate biopsies eventually led to the diagnosis of pcALCL. Subsequent imaging revealed stage IV disease with innumerable intensely fluorodeoxyglucose (FDG)-avid subcutaneous, intramuscular, and visceral foci, but paucity of lymph node involvement. The patient's condition deteriorated, and she died during her hospitalization. This case reviews the clinicopathologic findings of pcALCL, emphasizes the importance of clinicopathologic correlation in differentiating between CD30+ lymphoproliferative disorders, highlights the extremely rare phenomenon of systemic intramuscular and visceral disseminated disease occurring in pcALCL, and discusses implications for prognosis.
C1 [Dougher, Meaghan C.] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA.
   [Cartron, Alexander; Scott, Jennifer; Helm, Matthew] Penn State Hlth Milton S Hershey Med Ctr, Dept Dermatol, Hershey, PA USA.
   [Bayerl, Michael G.] Penn State Hlth Milton S Hershey Med Ctr, Dept Pathol, Hershey, PA USA.
C3 University of Pennsylvania; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Penn State Health;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Dougher, MC (通讯作者)，Dept Pathol & Lab Med, 3400 Spruce St,6 Founders Bldg, Philadelphia, PA 19104 USA.
EM meaghan.dougher@pennmedicine.upenn.edu;
   acartron@pennstatehealth.psu.edu; jboles@pennstatehealth.psu.edu;
   mbayerl@pennstatehealth.psu.edu; mhelm2@pennstatehealth.psu.edu
RI ; Helm, Matthew/AAX-1363-2020
OI Scott, Jennifer/0000-0001-7873-3392; 
FU Department of Dermatology at Penn State Health Milton S. Hershey Medical
   Center
FX The authors would like to acknowledge Jennifer Scott, MD, PhD, Klaus
   Helm, MD, and Brian Green, DO, of the Department of Dermatology at Penn
   State Health Milton S. Hershey Medical Center for their involvement in
   this patient case, Joseph Fotos, MD, of the Department of Radiology at
   Penn State Health Milton S. Hershey Medical Center for his involvement
   in this patient case and interpretation of the imaging with figure
   annotations, and Grace Weyant, MD, (Lancaster General Health) and Paul
   Haun, MD, (Penn Cutaneous Pathology Services) who reviewed the patient's
   prior biopsies.
CR Alberti-Violetti S, 2021, DERMATOPATHOL-BASEL, V8, P515, DOI 10.3390/dermatopathology8040054
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   Gambichler T, 2021, BRIT J DERMATOL, V185, P1259, DOI 10.1111/bjd.20630
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   Zhang YP, 2022, J CUTAN PATHOL, V49, P187, DOI 10.1111/cup.14147
NR 11
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0193-1091
EI 1533-0311
J9 AM J DERMATOPATH
JI Am. J. Dermatopathol.
PD APR
PY 2025
VL 47
IS 4
BP 311
EP 315
DI 10.1097/DAD.0000000000002896
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0FO9O
UT WOS:001446193800002
PM 39689258
DA 2026-07-24
ER

PT J
AU Coccolini, F
   Montori, G
   Ceresoli, M
   Catena, F
   Moore, EE
   Ivatury, R
   Biffl, W
   Peitzman, A
   Coimbra, R
   Rizoli, S
   Kluger, Y
   Abu-Zidan, FM
   Sartelli, M
   De Moya, M
   Velmahos, G
   Fraga, GP
   Pereira, BM
   Leppaniemi, A
   Boermeester, MA
   Kirkpatrick, AW
   Maier, R
   Bala, M
   Sakakushev, B
   Khokha, V
   Malbrain, M
   Agnoletti, V
   Martin-Loeches, I
   Sugrue, M
   Di Saverio, S
   Griffiths, E
   Soreide, K
   Mazuski, JE
   May, AK
   Montravers, P
   Melotti, RM
   Pisano, M
   Salvetti, F
   Marchesi, G
   Valetti, TM
   Scalea, T
   Chiara, O
   Kashuk, JL
   Ansaloni, L
AF Coccolini, Federico
   Montori, Giulia
   Ceresoli, Marco
   Catena, Fausto
   Moore, Ernest E.
   Ivatury, Rao
   Biffl, Walter
   Peitzman, Andrew
   Coimbra, Raul
   Rizoli, Sandro
   Kluger, Yoram
   Abu-Zidan, Fikri M.
   Sartelli, Massimo
   De Moya, Marc
   Velmahos, George
   Fraga, Gustavo Pereira
   Pereira, Bruno M.
   Leppaniemi, Ari
   Boermeester, Marja A.
   Kirkpatrick, Andrew W.
   Maier, Ron
   Bala, Miklosh
   Sakakushev, Boris
   Khokha, Vladimir
   Malbrain, Manu
   Agnoletti, Vanni
   Martin-Loeches, Ignacio
   Sugrue, Michael
   Di Saverio, Salomone
   Griffiths, Ewen
   Soreide, Kjetil
   Mazuski, John E.
   May, Addison K.
   Montravers, Philippe
   Melotti, Rita Maria
   Pisano, Michele
   Salvetti, Francesco
   Marchesi, Gianmariano
   Valetti, Tino M.
   Scalea, Thomas
   Chiara, Osvaldo
   Kashuk, Jeffry L.
   Ansaloni, Luca
TI The role of open abdomen in non-trauma patient: WSES Consensus Paper
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Open abdomen; Laparostomy; Non-trauma; Peritonitis; Pancreatitis;
   Vascular emergencies; Fistula; Nutrition; Re-exploration;
   Re-intervention; Closure; Biological; Synthetic; Mesh; Technique; Timing
ID ABDOMINAL COMPARTMENT SYNDROME; TOPICAL NEGATIVE-PRESSURE; ACELLULAR
   DERMAL MATRIX; VACUUM-ASSISTED CLOSURE; PRIMARY FASCIAL CLOSURE; VENTRAL
   HERNIA REPAIR; POSTOPERATIVE ENTEROCUTANEOUS FISTULAS; DAMAGE-CONTROL
   LAPAROTOMY; OPEN MANAGEMENT; COMPONENTS SEPARATION
AB The open abdomen (OA) is defined as intentional decision to leave the fascial edges of the abdomen un-approximated after laparotomy (laparostomy). The abdominal contents are potentially exposed and therefore must be protected with a temporary coverage, which is referred to as temporal abdominal closure (TAC). OA use remains widely debated with many specific details deserving detailed assessment and clarification. To date, in patients with intra-abdominal emergencies, the OA has not been formally endorsed for routine utilization; although, utilization is seemingly increasing. Therefore, the World Society of Emergency Surgery (WSES), Abdominal Compartment Society (WSACS) and the Donegal Research Academy united a worldwide group of experts in an international consensus conference to review and thereafter propose the basis for evidence-directed utilization of OA management in non-trauma emergency surgery and critically ill patients. In addition to utilization recommendations, questions with insufficient evidence urgently requiring future study were identified.
C1 [Coccolini, Federico; Montori, Giulia; Ceresoli, Marco; Pisano, Michele; Salvetti, Francesco; Ansaloni, Luca] Papa Giovanni XXIII Hosp, Gen Emergency & Trauma Surg dept, Piazza OMS 1, I-24127 Bergamo, Italy.
   [Catena, Fausto] Parma Maggiore Hosp, Emergency & Trauma Surg, Parma, Italy.
   [Moore, Ernest E.] Denver Hlth, Denver, CO 80204 USA.
   [Ivatury, Rao] Virginia Commonwealth Univ, Trauma Surg, Richmond, VA 23284 USA.
   [Biffl, Walter] Queens Med Ctr, Acute Care Surg, Honolulu, HI 96813 USA.
   [Peitzman, Andrew] Univ Pittsburgh, Sch Med, Dept Surg Trauma & Surg Serv, Pittsburgh, PA 15213 USA.
   [Coimbra, Raul] UC San Diego Hlth Syst, Dept Surg, San Diego, CA 92103 USA.
   [Rizoli, Sandro] St Michaels Hosp, Trauma & Acute Care Serv, Toronto, ON, Canada.
   [Kluger, Yoram] Div Gen Surg, Rambam Hlth Care Campus, Haifa, Israel.
   [Abu-Zidan, Fikri M.] UAE Univ, Coll Med & Hlth Sci, Dept Surg, Al Ain, U Arab Emirates.
   [Sartelli, Massimo] Macerata Hosp, Dept Surg, Macerata, Italy.
   [De Moya, Marc; Velmahos, George] Massachusetts Gen Hosp, Dept Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA.
   [Fraga, Gustavo Pereira; Pereira, Bruno M.] Unicamp Campinas, FCM, Sao Paulo, Brazil.
   [Leppaniemi, Ari] Meilahti Hosp, Dept Surg 2, Helsinki, Finland.
   [Boermeester, Marja A.] Acad Med Ctr Amsterdam, Amsterdam, Netherlands.
   [Kirkpatrick, Andrew W.] Foothills Med Ctr, Dept Surg, Calgary, AB, Canada.
   [Maier, Ron] Harborview Med Ctr, Dept Surg, Seattle, WA 98104 USA.
   [Bala, Miklosh] Hadassah Med Ctr, Gen Surg Dept, Jerusalem, Israel.
   [Sakakushev, Boris] Univ Hosp, UMBA, Clin Gen Surg 1, St George Plovdiv, Plovdiv, Bulgaria.
   [Khokha, Vladimir] Mozir Hosp, Gen Surg, Mozir City, BELARUS.
   [Malbrain, Manu] Ziekenhius Netwerk Antwerpen, ICU, Antwerp, Belgium.
   [Malbrain, Manu] Ziekenhius Netwerk Antwerpen, High Care Burn Unit, Antwerp, Belgium.
   [Agnoletti, Vanni] Bufalini Hosp, ICU Dept, Cesena, Italy.
   [Martin-Loeches, Ignacio] Corporasio Sanitaria Pk Tauli, Crit Care Ctr, Sabdel, Spain.
   [Sugrue, Michael] Letterkenny Hosp, Gen Surg Dept, Letterkenny, Ireland.
   [Di Saverio, Salomone] Maggiore Hosp, Gen & Trauma Surg Dept, Bologna, Italy.
   [Griffiths, Ewen] Birmigham Hosp, Upper Gatrointestinal Surg, Birmigham, England.
   [Soreide, Kjetil] Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway.
   [Soreide, Kjetil] Univ Bergen, Dept Clin Med, Bergen, Norway.
   [Mazuski, John E.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63130 USA.
   [May, Addison K.] Vanderbilt Univ, Med Ctr, Div Trauma & Surg Crit Care, Dept Surg, Nashville, TN 37232 USA.
   [May, Addison K.] Vanderbilt Univ, Med Ctr, Dept Anesthesiol, Nashville, TN 37232 USA.
   [Montravers, Philippe] Univ Paris 07, Assistance Publ Hop Paris, CHU Bichat Claude, Bernard HUPNVS,Dept Anesthesie Reanimation, Paris, France.
   [Melotti, Rita Maria] Malpighi Univ Hosp, ICU Dept Sant Orsola, Bologna, Italy.
   [Marchesi, Gianmariano; Valetti, Tino M.] Papa Giovanni XXIII Hosp, ICU Dept, Bergamo, Italy.
   [Scalea, Thomas] Univ Maryland, Sch Med, Trauma Surg Dept, Baltimore, MD 21201 USA.
   [Chiara, Osvaldo] Osped Niguarda Ca Granda, Emergency & Trauma Surg Dept, Milan, Italy.
   [Kashuk, Jeffry L.] Assuta Med Ctr, Gen Surg Dept, Tel Aviv, Israel.
C3 ASST Papa Giovanni XXIII; University of Parma; University Hospital of
   Parma; Denver Health Medical Center; Virginia Commonwealth University;
   The Queen's Medical Center; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Toronto;
   Saint Michaels Hospital Toronto; Technion Israel Institute of
   Technology; Rambam Health Care Campus; United Arab Emirates University;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Universidade Estadual de Campinas; University of
   Helsinki; Helsinki University Central Hospital; University of Amsterdam;
   Academic Medical Center Amsterdam; University of Calgary; University
   Calgary Hospital; Harborview Medical Center; Hebrew University of
   Jerusalem; Hadassah University Medical Center; Hadassah University
   Hospital; Medical University Plovdiv; Autonomous University of
   Barcelona; Parc Tauli Hospital Universitari; AUSL di Bologna; Stavanger
   University Hospital; University of Bergen; Washington University
   (WUSTL); Vanderbilt University; Vanderbilt University; Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Bichat-Claude Bernard - APHP; Hopital Universitaire
   Saint-Louis - APHP; IRCCS Azienda Ospedaliero-Universitaria di Bologna;
   ASST Papa Giovanni XXIII; University System of Maryland; University of
   Maryland Baltimore; Ospedale Niguarda Ca' Granda; IRCCS Ca Granda
   Ospedale Maggiore Policlinico
RP Coccolini, F (通讯作者)，Papa Giovanni XXIII Hosp, Gen Emergency & Trauma Surg dept, Piazza OMS 1, I-24127 Bergamo, Italy.
EM federico.coccolini@gmail.com
RI ; Montori, Giulia/ABF-9661-2020; Martin-Loeches, Ignacio/H-4633-2013;
   MELOTTI, RITA MARIA/AAC-5989-2021; Griffiths, Ewen/H-3128-2019; ,
   Pereira BM/D-4542-2015; Agnoletti, Vanni/AAC-9854-2022; Ansaloni,
   Luca/AAP-9134-2020; Ceresoli, Marco/GMW-5356-2022; Søreide,
   Kjetil/A-9797-2010; Sakakushev, Boris/MGV-4913-2025; Coimbra,
   Raul/AAP-3019-2020; Malbrain, Manu/B-3680-2017; Ansaloni,
   Luca/AAJ-6507-2020; Coccolini, Federico/AAJ-6507-2020; /AAD-7440-2020;
   Pisano, Michele/G-9348-2018; Di Saverio, Salomone/G-1437-2012; Ivatury,
   Rao/H-2922-2019; Leppäniemi, Ari/GQZ-7991-2022; Khokha,
   Vladimir/IVU-7489-2023; Abu-Zidan, Fikri/GWE-2835-2022
OI Salvetti, Francesco/0000-0001-8472-5823; Montori,
   Giulia/0000-0002-7649-2174; Martin-Loeches, Ignacio/0000-0002-5834-4063;
   MELOTTI, RITA MARIA/0000-0001-6258-6607; Griffiths,
   Ewen/0000-0001-6630-3547; , Pereira BM/0000-0003-3763-1749; Agnoletti,
   Vanni/0000-0002-7093-2749; Ansaloni, Luca/0000-0001-6427-0307; Ceresoli,
   Marco/0000-0001-7935-3842; Søreide, Kjetil/0000-0001-7594-4354;
   Boermeester, Marja/0000-0003-3890-8105; Sakakushev,
   Boris/0000-0001-8399-0115; Coimbra, Raul/0000-0002-3759-6851; Malbrain,
   Manu/0000-0002-1816-5255; Ansaloni, Luca/0000-0001-6427-0307; Coccolini,
   Federico/0000-0001-6364-4186; 
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NR 196
TC 75
Z9 100
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD AUG 14
PY 2017
VL 12
AR 39
DI 10.1186/s13017-017-0146-1
PG 17
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA FE2EM
UT WOS:000408029300001
PM 28814969
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Cheesborough, JE
   Park, E
   Souza, JM
   Dumanian, GA
AF Cheesborough, Jennifer E.
   Park, Eugene
   Souza, Jason M.
   Dumanian, Gregory A.
TI Staged management of the open abdomen and enteroatmospheric fistulae
   using split-thickness skin grafts
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Abdominal wall reconstruction; Enteroatmospheric fistula;
   Enterocutaneous fistula; Open abdomen; Skin graft
ID ABDOMINAL-WALL RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; PLANNED VENTRAL
   HERNIA; PRIMARY FASCIAL CLOSURE; WOUND CLOSURE; WITTMANN PATCH;
   COMPARTMENT SYNDROME; POLYPROPYLENE MESH; TEMPORARY CLOSURE; TRAUMA
   PATIENTS
AB BACKGROUND: Management of the open abdomen with polyglactin 910 mesh followed by split-thickness skin grafts allows safe, early closure of abdominal wounds. This technique can be modified to manage enteroatmospheric fistulae. Staged ventral hernia is performed in a less inflamed surgical field.
   METHODS: A retrospective review was performed of 59 consecutive patients who underwent abdominal skin grafting for open abdominal wounds from 2001 to 2011.
   RESULTS: The median length of follow-up was 215 days. Thirty-one percent of patients presented with preexisting enteroatmospheric fistulae, and 41% required polyglactin 910 mesh placement before skin grafting. Partial or complete skin graft failure occurred in 7 patients. Four patients required repeat skin grafting. All patients ultimately achieved abdominal wound closure, and none developed de novo fistulae.
   CONCLUSIONS: With proper technique, skin grafting of the open abdomen with a planned ventral hernia repair is a safe and effective alternative to delayed primary closure. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Cheesborough, Jennifer E.; Park, Eugene; Souza, Jason M.; Dumanian, Gregory A.] Northwestern Univ, Feinberg Sch Med, Div Plast & Reconstruct Surg, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Dumanian, GA (通讯作者)，Northwestern Univ, Feinberg Sch Med, Div Plast & Reconstruct Surg, 675 N St Clair,Suite 19-250, Chicago, IL 60611 USA.
EM dumanian1@gmail.com
OI Park, Eugene/0000-0003-1874-1926
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 38
TC 19
Z9 22
U1 0
U2 12
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD APR
PY 2014
VL 207
IS 4
BP 504
EP 511
DI 10.1016/j.amjsurg.2013.07.040
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD7BN
UT WOS:000333416100009
PM 24315380
DA 2026-07-24
ER

PT J
AU D'Hondt, M
   Devriendt, D
   Van Rooy, F
   Vansteenkiste, F
   D'Hoore, A
   Penninckx, F
   Miserez, M
AF D'Hondt, Mathieu
   Devriendt, Dirk
   Van Rooy, Frank
   Vansteenkiste, Franky
   D'Hoore, Andre
   Penninckx, Freddy
   Miserez, Marc
TI Treatment of small-bowel fistulae in the open abdomen with topical
   negative-pressure therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Open abdomen; Enteroatmospheric fistula; Topical negative pressure
   therapy; VAC therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL DEFECTS; ENTEROCUTANEOUS
   FISTULAS; MANAGEMENT
AB BACKGROUND: An open abdomen (OA) can result from surgical management of trauma, severe peritonitis, abdominal compartment syndrome, and other abdominal emergencies. Enteroatmospheric fistulae (EAF) occur in 25% of patients with an OA and are associated with high mortality.
   METHODS: We report our experience with topical negative pressure (TNP) therapy in the management of EAF in an OA using the VAC (vacuum asisted closure) device (KCI Medical, San Antonio, TX). Nine patients with 17 EAF in an OA were treated with topical TNP therapy from January 2006 to January 2009. Surgery with enterectomy and abdominal closure was planned 6 to 10 weeks later.
   RESULTS: Three EAF closed spontaneously. The median time from the onset of fistulization to elective surgical management was 51 days. No additional fistulae occurred during VAC therapy. One patient with a short bowel died as a result of persistent leakage after surgery.
   CONCLUSIONS: Although previously considered a contraindication to TNP therapy, EAF can be managed successfully with TNP therapy. Surgical closure of EAFs is possible after several weeks. (C) 2011 Elsevier Inc. All rights reserved.
C1 [D'Hondt, Mathieu; Devriendt, Dirk; Van Rooy, Frank; Vansteenkiste, Franky] Groeninge Hosp, Dept Digest Surg, B-8500 Kortrijk, Belgium.
   [D'Hondt, Mathieu; D'Hoore, Andre; Penninckx, Freddy; Miserez, Marc] Univ Hosp Leuven, Dept Digest Surg, B-3000 Louvain, Belgium.
C3 KU Leuven; University Hospital Leuven
RP D'Hondt, M (通讯作者)，Groeninge Hosp, Dept Digest Surg, President Kennedylaan 4, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
OI , marc/0000-0002-7047-6114
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NR 22
TC 58
Z9 65
U1 0
U2 9
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2011
VL 202
IS 2
BP E20
EP E24
DI 10.1016/j.amjsurg.2010.06.025
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 811LW
UT WOS:000294213300003
PM 21601824
DA 2026-07-24
ER

PT J
AU D'Hondt, M
   Devriendt, D
   Van Rooy, F
   Vansteenkiste, F
AF D'Hondt, M.
   Devriendt, D.
   Van Rooy, F.
   Vansteenkiste, F.
TI Systemic peritoneal cavity lavage : a new strategy for treatment of the
   open septic abdomen
SO ACTA CHIRURGICA BELGICA
LA English
DT Article
DE peritonitis; laparostomy; vacuum assisted closure (VAC)
AB Introduction : Management of the open abdomen is a challenge, certainly when fistulisation is present. This paper presents a new treatment modality for this specific situation.
   Methods : Abdominal sepsis increases the net flow across the peritoneum to 300-500 ml/h. This flow was used to clean and flush the abdomen. Meropenem was administered, as antibiotic concentration in the peritoneal cavity is known to reach therapeutic levels after 8 hours. The abdominal fluid was captured using the abdominal VAC system and additional drains. The total amount of drained fluid was compensated intravenously. Thus, the concept was named "Systemic Peritoneal Cavity Lavage" (SPCL).
   Results : Four patients with an open abdomen and severe abdominal sepsis were treated with SPCL and got out of their septic state within two weeks despite fistulisation and ongoing bowel leakage in three patients. A partial enterectomy with removal of the fistulas could be performed six weeks later.
   Conclusion : SPCL is a promising method to treat patients with severe abdominal sepsis. In combination with the fistula isolation technique it permits delayed treatment of fistulas in a hostile abdomen where immediate removal of the septic focus is impossible.
C1 AZ Groeninge Hosp, Dept Digest Surg, B-8500 Kortrijk, Belgium.
RP D'Hondt, M (通讯作者)，AZ Groeninge Hosp, Dept Digest Surg, Reepkaai 4, B-8500 Kortrijk, Belgium.
EM mathieudhondt2000@yahoo.com
CR Cheatham ML, 2004, J TRAUMA, V56, P237, DOI 10.1097/01.TA.0000109858.55483.86
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NR 7
TC 3
Z9 3
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5458
J9 ACTA CHIR BELG
JI Acta Chir. Belg.
PD OCT
PY 2007
VL 107
IS 5
BP 583
EP 587
DI 10.1080/00015458.2007.11680130
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 234KU
UT WOS:000251163800024
PM 18074927
DA 2026-07-24
ER

PT J
AU Li, JB
   Pan, ZJ
   Yan, SG
   Zhao, X
AF Li, Jianbin
   Pan, Zhijun
   Yan, Shigui
   Zhao, Xiang
TI Single-cortex is better than double-cortex in fibula grafts for large
   tibia bone defect in a 2-year-old child A case report of a successful
   surgery and discussion of bone graft choices
SO MEDICINE
LA English
DT Article
DE bone defect; case report; fibular graft; infant
ID INDUCED-MEMBRANE TECHNIQUE; RECONSTRUCTION; RESECTION
AB Background: Large bone defect in infant or small patients has been little reported and the management of such a patient is difficult. Considering the little knowledge of this area, we present this special case of a successful single-cortex fibula graft for the treatment of a large tibia bone defect in a 2-year-old patient to share our experience.
   Casesummary: A 2-year-old male patient presented to our hospital with history of leg pain for 4 months. According to his medical records, he was involved in a traffic accident and diagnosed with open tibia fracture. A previous surgery of emergent debridement and external fixation was performed in our institution, leaving a 6-cm tibia bone defect. After that this patient received several times of vacuum sealing drainage (VSD), skin grafting, and changed external fixation to cast because of pin tract infection.
   The physical examination of the patient showed a healed skin wound and a good dorsal arterial pulse. X-ray indicated a large bone defect at the tibia fracture site with osteosclerosis at the fracture sections. This patient received ipsilateral single-cortex vascularized single-cortex fibula graft, other than double-cortex fibula graft. X-ray and CT scan 4 months after the operation confined bone healing. The patient returned to normal activities with an inconspicuous limb.
   Conclusion: Ipsilateral single-cortex fibula graft is effective for the treatment of large tibia bone defect in infant or small aged patients. It exhibited better potential benefits than double-cortex graft in such cases.
C1 [Li, Jianbin; Pan, Zhijun; Yan, Shigui; Zhao, Xiang] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed Surg, Hangzhou 310000, Zhejiang, Peoples R China.
   [Li, Jianbin; Pan, Zhijun; Yan, Shigui; Zhao, Xiang] Zhejiang Univ, Inst Orthopaed Res, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Zhao, X (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed Surg, Hangzhou 310000, Zhejiang, Peoples R China.
EM flyingzhao@zju.edu.cn
RI Pan, Zhijun/AAD-6547-2022
FU National Natural Science Foundation of China [81401785, 81371954]
FX All phases of this study are supported by National Natural Science
   Foundation of China (81401785 and 81371954).
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NR 16
TC 1
Z9 1
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2017
VL 96
IS 5
AR e5965
DI 10.1097/MD.0000000000005965
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EK9OM
UT WOS:000394253800038
PM 28151885
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wu, J
   Wang, Y
   Chen, WJ
   Lin, M
   Jiang, JW
   Jiang, HD
   Li, ZH
   Xu, KL
   Zhang, B
AF Wu, Jing
   Wang, Yao
   Chen, Wenjie
   Lin, Min
   Jiang, Jinwen
   Jiang, Hongde
   Li, Zehuan
   Xu, Kailei
   Zhang, Bin
TI Harnessing stromal vascular fraction-based therapies for wound healing:
   Mechanisms, synergies, and clinical translation
SO REGENERATIVE THERAPY
LA English
DT Article
DE Stromal vascular matrix; Diabetic wound; Chronic wound; Platelet-rich
   plasma; Angiogenesis
ID HUMAN ADIPOSE-TISSUE; STEM-CELLS; MACROPHAGE POLARIZATION; HOST
   RESPONSE; GEL; EPITHELIALIZATION; ANGIOGENESIS; IMPROVEMENT; HYDROGELS;
   FIBROSIS
AB Wound healing remains a major challenge in contemporary medicine, particularly with the increasing incidence of chronic wounds, such as those associated with diabetes and thermal injuries. Current treatments such as vacuum sealing drainage, topical therapies, and autologous skin grafting are limited by issues like poor therapeutic efficacy, frequent dressing changes, and immune responses. Cell-based therapies have shown promise but are hindered by single-cell type limitations and hostile wound microenvironments. The stromal vascular fraction (SVF) has emerged as a potential solution, where the enzymatic digestion (E-SVF) contains various cell types, including adipose-derived stem cells (ADSCs), endothelial cells, and fibroblasts, while mechanical digestion (MSVF) introduces additional extracellular matrix (ECM), termed stromal vascular matrix (SVM). This review systematically evaluates the applications of SVF and SVM in wound healing. SVF promotes wound repair through proangiogenic, immunomodulatory, and ECM remodeling effects. When combined with platelet-rich plasma (PRP) or biomaterials, its efficacy is further enhanced through the synergistic regulation of inflammation and angiogenesis. SVM, with preserved ECM, and SVM-conditioned medium (SVM-CM), rich in growth factors, demonstrate superior wound healing capabilities compared to conventional SVF. Despite the challenges posed by impaired viability and function of aged SVF-derived ADSCs and the low mechanical properties of SVM, emerging technologies, such as 3D cell cultures to enhance stemness and the integration of other biomaterials to improve mechanical strength, offer promising solutions. This review highlights the potential of SVF as an autologous, multifunctional strategy to address unmet needs in wound healing and provides insights into future clinical applications and research directions.
C1 [Wu, Jing; Chen, Wenjie; Lin, Min; Jiang, Jinwen; Jiang, Hongde; Li, Zehuan] Ningbo Univ, Hlth Sci Ctr, Ningbo 315211, Peoples R China.
   [Wu, Jing; Jiang, Jinwen; Jiang, Hongde; Li, Zehuan; Xu, Kailei] Ningbo Univ, Affiliated Hosp 1, Ctr Med & Engn Innovat, Cent Lab, Ningbo 315010, Zhejiang, Peoples R China.
   [Wang, Yao; Zhang, Bin] Ningbo Univ, Affiliated YangMing Hosp, Dept Hand & Foot Microsurg, Yuyao 315400, Zhejiang, Peoples R China.
   [Chen, Wenjie; Lin, Min] Ningbo Univ, Affiliated Peoples Hosp, Dept Plast Surg, Ningbo 315040, Peoples R China.
C3 Ningbo University; Ningbo University; Ningbo University; Ningbo
   University
RP Xu, KL (通讯作者)，Ningbo Univ, Affiliated Hosp 1, Ctr Med & Engn Innovat, Cent Lab, Ningbo 315010, Zhejiang, Peoples R China.; Zhang, B (通讯作者)，Ningbo Univ, Affiliated YangMing Hosp, Dept Hand & Foot Microsurg, Yuyao 315400, Zhejiang, Peoples R China.
EM xukailei@zju.edu.cn; bzsweetin@163.com
FU National Natural Science Foundation of China [12202387]; Natural Science
   Foundation of Zhejiang Province [ZCLTGY24E0501, LBY23H180001]; Ningbo
   Major Research and Development Plan Project [2023Z193, 2024Z208]
FX This work was supported by National Natural Science Foundation of China
   (12202387) , Natural Science Foundation of Zhejiang Province
   (ZCLTGY24E0501, LBY23H180001) , and Ningbo Major Research and
   Development Plan Project (2023Z193, 2024Z208).
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NR 162
TC 6
Z9 6
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3204
J9 REGEN THER
JI Regen. Ther.
PD DEC
PY 2025
VL 30
BP 692
EP 709
DI 10.1016/j.reth.2025.08.012
EA AUG 2025
PG 18
WC Cell & Tissue Engineering; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Engineering
GA 6SU9Z
UT WOS:001561179800001
PM 41424617
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ge, YN
   Saad, M
   Nemani, S
   Shi, YD
   Lineaweaver, WC
   Yang, YW
AF Ge, Yining
   Saad, Mariam
   Nemani, Sriya
   Shi, Yuedong
   Lineaweaver, William C.
   Yang, Yanwen
TI Diagnosis and Treatment of Skin Lesions in Renal Transplant Recipients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE renal transplant; cutaneous infection; skin cancer; PTLD; plastic and
   reconstructive surgery; BCC, basal cell carcinoma; EBV, Epstein-Barr
   virus; ENKL, extranodal NK/T-cell lymphoma; FTSG, full thickness skin
   graft; mTOR, mammalian target of rapamycin; NGS, next-generation
   sequencing; NK, natural killer; PTLD, posttransplant lymphoproliferative
   disorder; SCC, squamous cell carcinoma; VSD, vacuum sealing drainage
ID SQUAMOUS-CELL CARCINOMA; AESTHETIC SURGERY; LYMPHOMA; CANCER;
   IMMUNOSUPPRESSION; MALIGNANCY; THERAPY; PATIENT; RISK
AB BackgroundImmunosuppressive therapy is essential for to prevent graft rejection in renal transplant patients; however, it is associated with elevating the risk of several pathologies in these patients particularly infectious and neoplastic conditions. In this study, we explore the diagnosis and treatment of skin lesions in renal transplant patients.MethodsA retrospective chart review of 12 renal transplant recipients referred to plastic and reconstructive surgery with skin lesions from 2000 to 2020 was performed.ResultsThe mean age of the 12 patients was 49.6 years. Time to plastic surgery after renal transplantation ranged between 1 and 16 years. Nine cases of basal cell carcinoma, 2 cases of squamous cell carcinoma, and 1 case of skin and soft tissue infection of the lower extremity and cutaneous extranodal NK/T-cell lymphoma, nasal type was observed. Flaps, skin grafts, and artificial dermis grafts constitute the main reconstructive methods. There were no postoperative infections or wound dehiscence.ConclusionsCutaneous infections and skin malignancy account for most of the skin lesions developing after renal transplantation. Posttransplant lymphoproliferative disorder warrants equal attention and should not be disregarded. Early diagnosis and treatment significantly improve prognosis as patients with longer duration of transplant were found to have more aggressive tumors. Plastic and reconstructive surgery offers a safe therapeutic method of treatment in these cases.
C1 [Ge, Yining; Shi, Yuedong; Yang, Yanwen] Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
   [Saad, Mariam; Nemani, Sriya; Lineaweaver, William C.] Vanderbilt Univ Sch Med, Dept Plast Surg, Nashville, TN USA.
C3 Fudan University; Vanderbilt University
RP Ge, YN (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM ge.yining@zs-hospital.sh.cn; mariam.saad.1@vumc.org;
   sriya.nemani@vumc.org; shi.yuedong@zs-hospital.sh.cn;
   william.c.lineaweaver@vumc.org; yang.yanwen@zs-hospital.sh.cn
RI yang, yanwen/LRC-5259-2024
OI Nemani, Sriya/0009-0003-7286-1993
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NR 30
TC 1
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2024
VL 93
IS 2S
SU 1
BP S51
EP S54
DI 10.1097/SAP.0000000000003930
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A7R6W
UT WOS:001284476700015
PM 39101849
OA hybrid
DA 2026-07-24
ER

PT J
AU Ehya, REM
   Zhang, H
   Qi, BW
   Yu, AX
AF Ehya, Regis Ernest Mendame
   Zhang, Hao
   Qi, Baiwen
   Yu, Aixi
TI Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement
   to Promote Soft Tissue Granulation in the Treatment of Neuropathic
   Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized
   Controlled Trial
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID VACUUM SEALING DRAINAGE; HEALING TIMES; INFECTION; KNEE; THERAPY;
   ARTHROPLASTY; AMPUTATIONS; PREVENTION; MANAGEMENT; CHILDREN
AB This study explored the clinical effectiveness of antibiotic-loaded bone cement on primary treatment of diabetic foot infection. This is a randomized controlled study, including thirty-six patients with diabetic foot ulcer complicated by osteomyelitis who had undergone treatment between May 2018 and December 2019. Patients were randomly divided into control group (group A) and study group (group B). Patients in the intervention group received antibiotic-loaded bone cement repair as primary treatment, while patients in the control group received conventional vacuum sealing draining treatment. Clinical endpoints were assessed and compared between the two groups, including wound healing time, wound bacterial conversion, NRS pain score, number of wound dressing changes, and average hospitalization time. All patients were followed up for a period of 12 months after discharge. Results show that compared with the control group, patients in the study group had significant difference in the number of patients for baseline pathogens eradication, short NRS pain score, hospital length of stay and cost, wound surface reduction, healing time, low rate of complications, and infection recurrence. Based on the findings, we conclude that antibiotic-loaded bone cement can be used for treatment of wound in patient with diabetic foot infection. It can help to control wound infections, shorten hospital length of stay, reduce medical cost, and relieve both doctors' and patients' burden. The application of antibiotic-loaded bone cement is suitable for diabetic wound with soft tissue infection or osteomyelitis.
C1 [Ehya, Regis Ernest Mendame; Zhang, Hao; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Orthoped Trauma & Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped Trauma & Microsurg, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
EM qbw2004@sina.com; yuaixi666@163.com
OI Mendame ehya, Regis ernest/0000-0003-3275-6649
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NR 57
TC 30
Z9 33
U1 1
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JUL 14
PY 2021
VL 2021
AR 9911072
DI 10.1155/2021/9911072
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA TU1ZB
UT WOS:000680837900002
PM 34337074
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jin, YL
   Zhu, T
   Cai, X
   Fu, Z
   Pan, QL
   Tu, HX
   Wang, SX
   Li, Y
AF Jin, Yuanling
   Zhu, Tao
   Cai, Xiao
   Fu, Zheng
   Pan, Qianglong
   Tu, Haixia
   Wang, Shouxing
   Li, Yan
TI Identification and treatment of Enterococcus avium-induced
   diabetic foot ulcer: a case report and microbiome analysis
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE diabetic foot ulcers; E. avium; microbiome analysis; second-generation
   sequencing technology; minimal inhibit concentration
ID RISK-FACTORS; INFECTION; DISEASE
AB Diabetic foot ulcer (DFU) is a severe complication of diabetes. Due to conservative or delayed treatment, the majority of DFU patients frequently miss the optimal treatment window, thereby leading to amputation. Despite being a rare pathogen with low virulence, Enterococcus avium (E. avium) exhibits some antibiotic resistance and can be fatal for immunocompromised patients. This report describes a DFU case, caused by E. avium infection due to exposure to poultry. Wound microbiota was dynamically monitored using bacterial culture followed by 16S rRNA gene sequencing throughout the illness. Combination of antibiotics was administered to control the secondary infection.
   Case report: A 56-year-old man presented with a two-week history of redness, swelling, heat, pain, and pus discharge from a ruptured wound on his left heel. The patient was diagnosed with osteomyelitis and a Wagner grade 3 diabetic foot ulcer infection, complicated by the soft tissue infection in the left heel. Strain identification and antibiotic susceptibility tests were immediately performed after admission. The patient underwent three debridement procedures at the DFU site. However, we observed recurrent bacterial infections, based on the clinical progression. Second-generation sequencing detected various pathogens. After targeted treatment with Vacuum sealing drainage (VSD) combined with antibiotic bone cement, the patient's condition stabilised. A skin graft was subsequently performed. Antibiotics were used to control the infection and blood glucose level was controlled throughout the treatment.
   Conclusion: Thus, this report provides a comprehensive description of a DFU case, caused by E. avium. Antibiotics and surgical measures should be adjusted according to the pathogens responsible for wound infections in DFU patients. It is important to reduce the mortality and prevent irreversible amputations.
C1 [Jin, Yuanling; Zhu, Tao; Cai, Xiao; Pan, Qianglong; Tu, Haixia; Wang, Shouxing; Li, Yan] Nanjing Med Univ, Sir Run Run Hosp, Dept Clin Lab, Nanjing, Peoples R China.
   [Fu, Zheng] Nanjing Med Univ, Sir Run Run Hosp, Dept Hand Surg, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Wang, SX; Li, Y (通讯作者)，Nanjing Med Univ, Sir Run Run Hosp, Dept Clin Lab, Nanjing, Peoples R China.
EM wshx1120@126.com; yanli@njmu.edu.cn
RI tu, haixia/NEC-1248-2025; Fu, Zheng/LTF-9857-2024
FU National Natural Science Foundation of China, Sir Run Run hospital, and
   Nanjing Medical University
FX We thank the staff of the clinical microbiology laboratory at Sir Run
   Run hospital, Nanjing Medical University for help with initial isolation
   and characterization of the isolate.
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NR 50
TC 1
Z9 2
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD DEC 20
PY 2024
VL 11
AR 1502337
DI 10.3389/fmed.2024.1502337
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R0O5L
UT WOS:001388555900001
PM 39760042
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kang, YQ
   Wu, YW
   Ma, YH
   Liu, J
   Gu, J
   Zhou, M
   Wang, YP
   Lin, F
   Rui, YJ
AF Kang, Yongqiang
   Wu, Yongwei
   Ma, Yunhong
   Liu, Jun
   Gu, Jun
   Zhou, Ming
   Wang, Yapeng
   Lin, Fang
   Rui, Yongjun
TI "Primary free-flap tibial open fracture reconstruction with the
   Masquelet technique" and internal fixation
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Lower extremity trauma; Free-flap; Reconstruction; Masquelet; Open
   fracture; Gustilo grade III
ID INDUCED MEMBRANE; DEFECTS; MANAGEMENT; INFECTION; TRAUMA; TIME
AB Background: Grade III open fractures of the lower extremity are serious injuries and are difficult to reconstruct. The optimal treatment for such injuries is unclear. We aimed to determine the safety and efficacy of orthoplastic reconstruction, using a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation for Gustilo grade IIIB/C open tibial fractures.
   Methods: From April 2018 to April 2019, 15 patients, ranging from 19 to 72 years old, with Gustilo grade IIIB/C open fractures were treated using a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation. This involved wound debridement and removal of free bone fragments, followed by bone cement packing of the defect, external fixation, and vacuum sealing drainage treatment. The final stage involved switching from external to internal fixation and wound repair using a free anterolateral thigh flap. Repair time ranged from 2 to 7 days. Flap size ranged from 25 x 15 cm(2) to 13 x 7cm(2). Hospital stay ranged from 11 to 50 days (mean, approximately 33.3 days). Bone cement was removed after 6-19 weeks and replaced with autogenic cancellous bone.
   Results: All flaps survived without incident. One patient experienced a wound infection, but there were no deep infections. For all patients, bone union was achieved after 4 to 7 months.
   Conclusion: The use of a primary free anterolateral thigh flap combined with the Masquelet technique and internal fixation is a safe and effective procedure for reconstruction of Gustilo grade IIIB/C open fractures. (C) 2020 The Authors. Published by Elsevier Ltd.
C1 [Kang, Yongqiang; Wu, Yongwei; Ma, Yunhong; Liu, Jun; Gu, Jun; Zhou, Ming; Wang, Yapeng; Lin, Fang; Rui, Yongjun] Soochow Univ, Dept Traumat Orthoped, Wuxi Peoples Hosp 9, Wuxi, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Rui, YJ (通讯作者)，Soochow Univ, Wuxi Peoples Hosp 9, 999 Liangxi Rd, Wuxi 214062, Jiangsu, Peoples R China.
EM wxswkryj123@126.com
RI Rui, Yongjun/PFI-5346-2025
FU Construction target of clinical medical center in Wuxi; General Project
   of Jiangsu Provincial Department of Health [H077]
FX This work was supported by the Construction target of clinical medical
   center in Wuxi, and by the General Project of Jiangsu Provincial
   Department of Health (H077).
CR Arnez ZM, 2017, J RECONSTR MICROSURG, V33, pS3, DOI 10.1055/s-0037-1603737
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NR 19
TC 28
Z9 45
U1 0
U2 10
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD DEC
PY 2020
VL 51
IS 12
BP 2970
EP 2974
DI 10.1016/j.injury.2020.10.039
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA PH2CT
UT WOS:000600228400037
PM 33097199
OA hybrid
DA 2026-07-24
ER

PT J
AU Gao, YL
   Liu, Y
   Hu, HY
   Gao, SH
   Zhou, JL
AF Gao, Yuling
   Liu, Yang
   Hu, Hongyu
   Gao, Shunhong
   Zhou, Junlin
TI Tibial periosteum flap combined with autologous bone grafting in the
   treatment of Gustilo-IIIB/IIIC open tibial fractures
SO OPEN MEDICINE
LA English
DT Article
DE Gustilo-IIIB/III C injury; bone-skin defect; flap; periosteal flap;
   tibial fracture
ID TRAUMA; RECONSTRUCTION
AB Purpose Gustilo IIIB/C injuries are common for tibia diaphysis fractures with high rates of nonunion, osteomyelitis, and amputation. However, the managements on tibial Gustilo IIIB/C injuries are still controversial and individual. The aim of this study is to introduce the tibial periosteum flap combined with autologous bone grafting to treat Gustilo-IIIB/IIIC injuries.Methods Sixteen Gustilo type IIIB/C tibial fracture patients who underwent tibial periosteum flaps with autologous bone grafting surgeries were retrospectively studied. In the first stage, the wound was treated with debridement and the fracture was reduced and fixed with an external fixator. After covering with vacuum sealing drainage for 7 days, the wound areas were repaired by flaps. When the flaps survived and external fixators were removed, the tibial periosteum flaps were taken with autologous bone grafting for bone defects.Results The tibia fractures were comminuted fractures with mean size of segment bone defects 3.1 +/- 1.3 cm. All the flaps survived and the wound healed in the first stage after an average of 1.5 +/- 0.6 months. The mean size of the flap was 13.2 +/- 2.8 cm x 7.3 +/- 3.1 cm. All the autografts healed in 4.5 +/- 0.7 months without infection and malunion. There was no pain in the affected limb. The weight-bearing and walking function were restored.Conclusion Tibial periosteum flap combined with autologous bone grafting is effective to treat bone-skin defect of leg with Gustilo-IIIB/IIIC injury.
C1 [Hu, Hongyu; Gao, Shunhong] Second Hosp Tangshan, Dept Hand Surg, Jianshe Rd 21, Tangshan 063000, Hebei, Peoples R China.
   [Zhou, Junlin] Capital Med Univ, Beijing Chaoyang Hosp, Gongtinan Rd 8, Beijing 100020, Peoples R China.
   [Gao, Yuling; Liu, Yang] Capital Med Univ, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Gao, SH (通讯作者)，Second Hosp Tangshan, Dept Hand Surg, Jianshe Rd 21, Tangshan 063000, Hebei, Peoples R China.; Zhou, JL (通讯作者)，Capital Med Univ, Beijing Chaoyang Hosp, Gongtinan Rd 8, Beijing 100020, Peoples R China.
EM 854824553@qq.com; y0ring1996@163.com; 15532550871@163.com;
   gshdj@126.com; junlinzhou_article@outlook.com
FU Beijing Key Clinical Specialty Project
FX The corresponding author Junlin Zhou discloses receipt of the following
   financial support for the research, authorship, and publication of this
   article: Beijing Key Clinical Specialty Project.
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NR 23
TC 0
Z9 1
U1 3
U2 6
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD SEP 20
PY 2024
VL 19
IS 1
AR 20241038
DI 10.1515/med-2024-1038
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G4D5E
UT WOS:001316165200001
PM 39308921
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, ZW
   Wang, XJ
   Zhang, KY
   Xian, HY
AF Wang, Zhuo Wei
   Wang, Xue Jiu
   Zhang, K. Y.
   Xian, H. Y.
TI Correlation between p16 and Interleukin-2 Gene Expression and Oral and
   Maxillofacial Wound Healing
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Oral and maxillofacial trauma; p16; interleukin-2; trauma healing
ID INFECTIONS; IL-2
AB To analyze the relationship between p16 and interleukin-2 protein and messenger RNA levels and wound healing in patients with oral and maxillofacial trauma. 86 patients with oral and maxillofacial trauma were selected in our hospital from June 2018 to June 2020 and divided into good and poor trauma healing group. All patients were treated with vacuum sealing drainage and given empirical antibacterial anti-infective medication, nutritional support and correction of fluid-electrolyte disturbances for 7 d. Serum levels of inflammatory factors were measured before and after 7 d of treatment. The levels of interleukin-2, p16 and messenger RNA were measured by western blot and polymerase chain reaction. White blood cells, tumor necrosis factor alpha, interleukin-6, C-reactive protein and procalcitonin were lower in both groups than before treatment while the phosphorylated form of p16/p16, phosphorylated form of interleukin-2/interleukin-2 proteins and messenger RNA levels were lower immediately after extubation (p<0.05). Pearson correlation analysis revealed that phosphorylated form of p16/p16 and phosphorylated form of interleukin-2/interleukin-2 were significantly lower in the group immediately after extubation (p<0.05). Phosphorylated form of p16/p16 and phosphorylated form of interleukin-2/interleukin-2 were positively correlated with white blood cells, tumor necrosis factor alpha, interleukin-6, C-reactive protein and procalcitonin after treatment (p<0.001). It is concluded that p16 and interleukin-2 in the drainage fluid of patients with oral and maxillofacial trauma can promote the process of wound healing by promoting the release of serum inflammatory factors.
C1 [Wang, Zhuo Wei] Beijing Tradit Chinese Med Hosp, Shunyi Hosp, Dept Stomatol, Beijing 101300, Peoples R China.
   [Wang, Xue Jiu; Zhang, K. Y.] Beijing Stomatol Hosp, Dept Maxillofacial Trauma Orthognath Surg, Beijing 100050, Peoples R China.
   [Xian, H. Y.] Beijing Shunyi Hosp, Dept Ophthalmol, Beijing 101300, Peoples R China.
C3 Capital Medical University
RP Wang, ZW (通讯作者)，Beijing Tradit Chinese Med Hosp, Shunyi Hosp, Dept Stomatol, Beijing 101300, Peoples R China.
EM syyykq@163.com
FU Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital
FX This work was supported by the Shunyi Hospital, Beijing Traditional
   Chinese Medicine Hospital.
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NR 23
TC 0
Z9 0
U1 0
U2 1
PU INDIAN PHARMACEUTICAL ASSOC
PI MUMBAI
PA KALINA, SANTA CRUZ EAST, MUMBAI, 00000, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PY 2021
VL 83
SI 5
BP 169
EP 176
DI 10.36468/pharmaceutical-sciences.spl.348
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XT8QK
UT WOS:000733845400026
OA gold
DA 2026-07-24
ER

PT J
AU Jin, L
AF Jin, Lei
TI Observation of the effects of two-stage irrigation therapy, combined
   with pedicled flaps, for treatment of infected tissue defects of the
   ankles and feet
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Irrigation; vacuum sealing drainage; infected tissue; flap
ID RISK-FACTORS; DRAINAGE
AB Objective: The aim of this study was to compare the clinical efficacy of two-stage irrigation combined with pedicled flaps and dressing-debridement-dressing circulation for treatment of infected tissue defects of the ankle and foot. Methods: Clinical data of 86 patients with infected tissue defects of the ankle and foot were analyzed, retrospectively. Results: Differences in ankle circumferences, pre- and post-operative, in group A at the 1st, 3rd, and 5th month were significantly smaller than those in group B (all P<0.001), as were visual analog scale (VAS) scores at the same time points (all P<0.001). Verbal rating scale (VRS) scores in group A at the 1st, 3rd, and 5th month were also lower than those in group B (P=0.001). The number of bacteria in group A was less than group B on the 10th day after the operation, as well as 2 weeks before and 2 weeks after drainage tube removal (all P<0.001). Wound healing rates in group A were significantly higher than those in group B at 12 months after the operation (P<0.001). Average hospitalization times and number of dressing changes in group A were respectively shorter and fewer, compared with group B (P<0.001 and P=0.002, respectively). Conclusion: Two-stage irrigation combined with pedicled flaps could reduce local inflammation, edema, pain, and bacterial colonization, as well as facilitate wound healing, shorten hospitalization times, and reduce the average number of dressing changes.
C1 [Jin, Lei] Shanghai Fengxian Dist Hosp, Dept Orthoped, 6600 Nanfeng Rd, Shanghai 201400, Peoples R China.
RP Jin, L (通讯作者)，Shanghai Fengxian Dist Hosp, Dept Orthoped, 6600 Nanfeng Rd, Shanghai 201400, Peoples R China.
EM jinlei75a@163.com
CR Brogden C, 2018, J SPORT REHABIL, P1
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NR 28
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 4
BP 3975
EP 3981
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HW2DW
UT WOS:000466494200098
DA 2026-07-24
ER

PT J
AU Li, ZG
   Shi, CN
   Wu, X
   Zhuang, ZW
   Xu, YQ
   Zhang, ZF
   Qiu, JH
AF Li, Zhigang
   Shi, Chunnan
   Wu, Xiong
   Zhuang, Zhiwei
   Xu, Yongquan
   Zhang, Zefeng
   Qiu, Jinghu
TI A feasibility study of a novel closed flowing vacuum-assisted technique
   (CFVAT) in managing fracture-related infection with implant retention
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Continuous irrigation; Fracture-related infection; Drainage technique;
   Implant retention; CFVAT
AB Objective The Closed Flowing Vacuum-Assisted Technique (CFVAT) is an innovative approach achieving continuous irrigation within a sealed wound environment, which enables active fluid circulation and establishes an efficient flowing-drainage mode under negative pressure. This study aims to conduct the first evaluation comparing the clinical outcomes of CFVAT versus the traditional Vacuum Sealing Drainage (VSD) technique in the management of early (<= 6 weeks) fracture-related infection (FRI) involving internal fixation and classified as Cierny-Mader type II. Methods A retrospective study was conducted on 33 patients with early FRI (<= 6 weeks, Cierny-Mader II) following internal fixation between 2021 and 2024. All patients underwent debridement with retention of internal fixation. The study group (n = 13) received CFVAT, while the control group (n = 20) received VSD. Patient demographics, fracture site, time from initial surgery to infection, inflammatory markers, number of required surgeries, total treatment duration, and costs were compared. Results The primary healing rate was 92.3% in the CFVAT group and 60% in the VSD group. The one-year long-term healing rates were 92.3% and 90%, respectively. The CFVAT group demonstrated advantages in the number of surgeries, treatment duration, and overall cost (P < 0.05). Conclusion For a narrow clinical scenario-specifically early FRI (<= 6 weeks) with retained internal fixation and Cierny-Mader type II anatomy-CFVAT may yield better outcomes than VSD in selected process and cost endpoints. These findings suggest that CFVAT has the potential to achieve wound closure after initial debridement while controlling infection. However, VSD remains a standard adjuvant therapy in FRI care, and the superiority of CFVAT requires validation through prospective randomized controlled trials.
C1 [Li, Zhigang; Shi, Chunnan; Wu, Xiong; Zhuang, Zhiwei; Xu, Yongquan; Zhang, Zefeng; Qiu, Jinghu] Jinjiang Municipal Hosp, Shanghai Peoples Hosp Fujian 6, Dept Traumat Orthoped, Jinjiang 362200, Fujian, Peoples R China.
RP Li, ZG (通讯作者)，Jinjiang Municipal Hosp, Shanghai Peoples Hosp Fujian 6, Dept Traumat Orthoped, Jinjiang 362200, Fujian, Peoples R China.
EM dslzg@163.com
RI Shi, Chunnan/KIK-5950-2024; Li, Zhigang/PHE-4609-2026
OI Shi, Chunnan/0000-0001-5820-5349; 
FU Cooperative Innovation Project of Jinjiang Municipal Hospital (Shanghai
   Sixth People's Hospital, Fujian); Huaqiao University [YX2024007]
FX This study was supported by the Cooperative Innovation Project of
   Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital, Fujian)
   and Huaqiao University (No. YX2024007) awarded to Li Zhigang. The
   funders played no role in the design, conduct, or reporting of this
   study.
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NR 33
TC 0
Z9 0
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JAN 14
PY 2026
VL 21
IS 1
AR 36
DI 10.1186/s13018-025-06489-2
PG 15
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CD3LW
UT WOS:001663080000003
PM 41535948
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Huang, LS
   Wang, LF
   Yang, JH
   Zhang, HB
AF Huang Lisong
   Wang Lianfu
   Yang Jinhong
   Zhang Haibin
TI Clinical effect analysis of using medical glue versus conventional
   suturing to treat dog bite in children's maxillofacial region after
   negative pressure sealing drainage
SO MEDICINE
LA English
DT Article
DE children; dog bite; maxillofacial region; medical glue; negative
   pressure sealing drainage
ID WOUND THERAPY; INJURIES
AB Background: To compare the clinical effectiveness of applying medical glue versus conventional suturing after primary suturing and continuous vacuum sealing drainage (VSD) technology in the treatment of facial wounds caused by dog bites in children's maxillofacial region, with respect to operation time, wound infection rate, treatment effect, and patient satisfaction. Methods: From May 2020 to July 2022, 68 children with a dog bite in the maxillofacial region were randomly divided into medical glue and conventional suturing groups. The patients in both groups were treated with conventional debridement, tetanus and/or rabies immunization, and antibiotic therapy. The medical glue group was treated with VSD after the first-stage of the loose suture of the wound. After 5 days, the suture was removed, and the wound was tightly bonded with medical glue again. The conventional suturing group was treated with VSD after the first-stage of loose suture of the wound. The primary outcomes were the operation time and satisfaction of the 2 groups, and the secondary outcomes was the wound infection rate. Results: The operation time of the medical glue group was significantly lower than that of the conventional suturing group. However, there was no significant difference between the 2 groups in the wound infection rate. Still, the patient satisfaction was significantly better in the medical glue group than the conventional suturing group with statistically significant difference (P <.05). Conclusion: In conclusion, applying medical glue after using negative pressure sealing drainage in treating maxillofacial dog bites can reduce surgeons work intensity, lessen children's pain, and improve the clinical treatment effect.
C1 [Huang Lisong; Wang Lianfu; Yang Jinhong; Zhang Haibin] Aerosp Ctr Hosp, Beijing 100049, Peoples R China.
C3 Aerospace Center Hospital
RP Zhang, HB (通讯作者)，Aerosp Ctr Hosp, Beijing 100049, Peoples R China.
EM dr_zhb@163.com
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NR 36
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 15
PY 2023
VL 102
IS 37
DI 10.1097/MD.0000000000034837
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M4049
UT WOS:001630537400001
PM 37713853
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ren, GH
   Xiang, DY
   Wu, XH
   Chen, YB
   Li, RG
AF Ren, Gao-hong
   Xiang, Da-yong
   Wu, Xiao-hu
   Chen, Yun-biao
   Li, Runguang
TI A neglected problem in the utilization of free anterolateral thigh flap
   toward reconstructing complicated wounds of extremities: the
   obliteration of deep dead space
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Chimeric flap; Anterolateral thigh perforator flap; Complex wounds;
   Wound reconstruction; Deep dead space
ID VACUUM SEALING DRAINAGE; SOFT-TISSUE DEFECTS; BONE DEFECTS;
   TRANSPLANTATION
AB BackgroundDeep dead space may be thought as an independent risk factor of the poor infection control after flap reconstruction in complex limb wounds. But it can be easily neglected. The conventional skin flap and musculocutaneous flap are difficult to obliterate the deep dead space in irregular shape effectively. It was investigated that the clinical application of chimeric anterolateral thigh perforator flap in the treatment of complex wounds complicated with deep dead space of the extremities in the paper.MethodsFifty-six cases complicated with deep dead space wounds were registered in group. Following thorough debridement and treatment with VSD, the granulation tissues grew with well-controlled infection. And then the chimeric anterolateral thigh perforator flap was used to obliterate the deep dead space and repair the wounds. The postoperative flap survival and infection conditions were evaluated.ResultsOverall, the infection was effectively controlled, without persistent exudation or sinus tract formation after wound healing. While 5 cases lost to follow-up, the remaining 51 cases were followed up until 15months on average. Generally, the affected extremities recovered satisfactorily with normal appearances and texture of the flaps, along with normal functions. Importantly, no recurrence of infection was observed.ConclusionDuring the grafting of chimeric perforator flap pedicled with lateral thigh muscle flap, the muscle flap is recommended to obliterate the deep dead space while the skin flap is being used to cover the wound. The combination of these two technologies performed well in the repair and reconstruction of the complex wounds of the extremities, possessing potential for broader clinical application.
C1 [Ren, Gao-hong; Xiang, Da-yong; Wu, Xiao-hu; Chen, Yun-biao] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed & Traumatol, Guangzhou 510515, Peoples R China.
   [Ren, Gao-hong; Xiang, Da-yong; Wu, Xiao-hu; Chen, Yun-biao] Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou 510515, Peoples R China.
   [Li, Runguang] Southern Med Univ, Affiliated Hosp 3, Dept Orthoped, Guangzhou 510610, Peoples R China.
   [Li, Runguang] Orthopaed Hosp Guangdong Prov, Guangzhou 510610, Peoples R China.
   [Li, Runguang] Acad Orthopaed, Guangzhou 510610, Guangdong, Peoples R China.
   [Li, Runguang] Linzhi Peoples Hosp, Dept Orthoped, Linzhi 860000, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Li, RG (通讯作者)，Southern Med Univ, Affiliated Hosp 3, Dept Orthoped, Guangzhou 510610, Peoples R China.; Li, RG (通讯作者)，Orthopaed Hosp Guangdong Prov, Guangzhou 510610, Peoples R China.
EM lirunguang79@163.com
OI Runguang, Li/0000-0002-4703-7180
FU Key Projects of President Foundation of Nanfang Hospital, Southern
   Medical University [2017A001]; Shanghai Wang Zhengguo Trauma Medical
   Development Foundation [2017KJB-GK-001]; Natural Science Foundation of
   Guangdong Province [2018A030313640, 2019A1515012176]; National Natural
   Science Foundation of China [81101366]
FX Key Projects of President Foundation of Nanfang Hospital, Southern
   Medical University (2017A001); Shanghai Wang Zhengguo Trauma Medical
   Development Foundation (2017KJB-GK-001); Natural Science Foundation of
   Guangdong Province (Approval no. 2018A030313640, 2019A1515012176);
   National Natural Science Foundation of China (81101366).
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NR 27
TC 12
Z9 14
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 21
PY 2020
VL 15
IS 1
AR 483
DI 10.1186/s13018-020-01914-0
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA OM0TR
UT WOS:000585743400001
PM 33087149
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Älgå, A
   Haweizy, R
   Bashaireh, K
   Wong, S
   Lundgren, KC
   von Schreeb, J
   Malmstedt, J
AF Alga, Andreas
   Haweizy, Rawand
   Bashaireh, Khaldoon
   Wong, Sidney
   Lundgren, Kalle Conneryd
   von Schreeb, Johan
   Malmstedt, Jonas
TI Negative pressure wound therapy versus standard treatment in patients
   with acute conflict-related extremity wounds: a pragmatic, multisite,
   randomised controlled trial
SO LANCET GLOBAL HEALTH
LA English
DT Article
ID OPEN FRACTURE
AB Background In armed conflict, injuries among civilians are usually complex and commonly affect the extremities. Negative pressure wound therapy (NPWT) is an alternative to standard treatment of acute conflict-related extremity wounds. We aimed to compare the safety and effectiveness of NPWT with that of standard treatment.
   Methods In this pragmatic, randomised, controlled superiority trial done at two civilian hospitals in Jordan and Iraq, we recruited patients aged 18 years or older, presenting with a conflict-related extremity wound within 72 h after injury. Participants were assigned (1:1) to receive either NPWT or standard treatment. We used a predefined, computer-generated randomisation list with three block sizes. Participants and their treating physicians were not masked to treatment allocation. The primary endpoint was wound closure by day 5. The coprimary endpoint was net clinical benefit, defined as a composite of wound closure by day 5 and freedom from any bleeding, wound infection, sepsis, or amputation of the index limb. Analysis was by intention to treat. The trial is registered with ClinicalTrials. gov, number NCT02444598, and is closed to accrual.
   Findings Between June 9, 2015, and Oct 24, 2018, 174 patients were randomly assigned to either the NPWT group (n=88) or the standard treatment group (n=86). Five patients in the NPWT group and four in the standard treatment group were excluded from the intention-to-treat analysis. By day 5, 41 (49%) of 83 participants in the NPWT group and 49 (60%) of 82 participants in the standard treatment group had closed wounds, with an absolute difference of 10 percentage points (95% CI -5 to 25, p=0.212; risk ratio [RR] 0.83, 95% CI 0.62 to 1.09). Net clinical benefit was seen in 33 (41%) of 81 participants in the NPWT group and 34 (44%) of 78 participants in the standard treatment group, with an absolute difference of 3 percentage points (95% CI -12 to 18, p=0.750; RR 0.93, 95% CI 0.65 to 1.35). There was one in-hospital death in the standard treatment group and none in the NPWT group. The proportion of participants with sepsis, bleeding leading to blood transfusion, and limb amputation did not differ between groups.
   Interpretation NPWT did not yield superior clinical outcomes compared with standard treatment for acute conflict-related extremity wounds. The results of this study not only question the use of NPWT, but also question the tendency for new and costly treatments to be introduced into resource-limited conflict settings without supporting evidence for their effectiveness. This study shows that high-quality, randomised trials in challenging settings are possible, and our findings support the call for further research that will generate context-specific evidence. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.
C1 [Alga, Andreas; Malmstedt, Jonas] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, SE-17177 Stockholm, Sweden.
   [Haweizy, Rawand] Hawler Med Univ, Coll Med, Erbil, Iraq.
   [Bashaireh, Khaldoon] Jordan Univ Sci & Technol, Dept Special Surg, Irbid, Jordan.
   [Wong, Sidney] Operat Ctr Amsterdam, Med Sans Frontieres, Amsterdam, Netherlands.
   [Lundgren, Kalle Conneryd] Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Alga, Andreas; von Schreeb, Johan] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Hawler Medical
   University; Jordan University of Science & Technology; Doctors Without
   Borders; Karolinska Institutet; Karolinska University Hospital;
   Karolinska Institutet
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, SE-17177 Stockholm, Sweden.
EM andreas.alga@ki.se
RI Lundgren, Kalle/E-9056-2015; Älgå, Andreas/B-1070-2019
OI Älgå, Andreas/0000-0001-5245-7668; Bashaireh,
   Khaldoon/0000-0003-0580-2355; Malmstedt, Jonas/0000-0002-2758-9623
FU Stockholm County Council; Swedish National Board of Health and Welfare;
   Medecins Sans Frontieres
FX The Stockholm County Council, the Swedish National Board of Health and
   Welfare, and Medecins Sans Frontieres.
CR Aboutanos MB, 1997, J TRAUMA, V43, P719, DOI 10.1097/00005373-199710000-00031
   Älgå A, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15122709
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   Älgå A, 2018, SCAND J TRAUMA RESUS, V26, DOI 10.1186/s13049-018-0517-y
   Älgå A, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3149-y
   Alkire BC, 2015, LANCET GLOB HEALTH, V3, pE316, DOI 10.1016/S2214-109X(15)70115-4
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   WHO, 2019, SYR AR REP 1 STEPS R
NR 23
TC 24
Z9 30
U1 0
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2214-109X
J9 LANCET GLOB HEALTH
JI Lancet Glob. Health
PY 2020
VL 8
IS 3
BP E423
EP E429
DI 10.1016/S2214-109X(19)30547-9
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KN5BJ
UT WOS:000514852000031
PM 32087175
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Leuchter, M
   Hitzbleck, M
   Schafmayer, C
   Philipp, M
AF Leuchter, Matthias
   Hitzbleck, Michael
   Schafmayer, Clemens
   Philipp, Mark
TI Use of incisional preventive negative pressure wound therapy in open
   incisional hernia repair: Who benefits?
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE abdominal wall; hernia; iNPWT; matched pair; ROC; surgical site
   infection; wound healing
ID SURGICAL SITE OCCURRENCE; MANAGEMENT; VALIDATION; INFECTION; SCORE
AB Complex surgery of abdominal wall hernia continues to bear the major concern of wound healing disorders. Technical modifications have not been able to sufficiently prevent wound healing impairments or infections, even in clean elective cases, especially when dealing with large-scale hernia defects. Incisional negative pressure wound therapy (iNPWT) in its intentional use as a preventive tool has recently found its way from theoretical and experimental advantages to the clinical routine. Different indications have been defined but evidence is lacking. We performed a retrospective analysis (1/2014-5/2019) of all ventral hernia repairs (n = 386) done in our institution as open sublay mesh reinforcement, partially requiring component separation (CS), receiving iNPWT in selected cases based on single surgeon experience. Pre- and perioperative data included patient and hernia characteristics as well as the employed mesh sizes. Postoperative follow-up (median 38.5 months [interquartile range: 23.4, 53.3]) extended beyond patient dismissal and included the rate of re-admission due to wound healing disorders. The primary outcome was the incidence of surgical site occurrences (SSO). Secondary endpoints included wound-related readmissions, reoperations and recurrences. Patients were matched based on propensity scores in a 1:1 ratio. Propensity scores were calculated based on five preoperative variables, including sex, body-mass-index, American Society of Anesthesiology classification, recurrent hernia repair and operation technique, to identify significant parameters. The rate of SSO was 12% (n = 46) for all operated cases, and the rate of surgical site infection (SSI) was 8.8% (n = 34). In the subgroup of CS (n = 40), the rate increased to 15% (n = 6). The usage of iNPWT (n = 54) led to an in-hospital SSO rate of 14.8% (n = 8) but increased to 33.3% (n = 18) when including the re-admission rate. The SSI rate for the iNPWT cohort was 14.8% (n = 8) with a consecutive need for reoperation (Clavien-Dindo IIIb) in 87.5% (n = 7). In the matched-pair analysis, the hernia-size and mesh-size were the main risk factors for SSO. The use of iNPWT significantly reduced this statistical effect (p = 0.405). In a large and representative patient cohort, we were able to demonstrate that the advantage of iNPWT used after complex abdominal wall repair does not come first hand. Especially in the follow-up, we found a relevant increase in wound healing problems after dismissal. To proof the benefit of iNPWT in these heterogeneous patients, we could identify hernia size and mesh size as individual risk factors that were nihilated by the use of iNPWT. We found it to be favourable to use iNPWT when mesh-size exceeded 450 cm(2).
C1 [Leuchter, Matthias; Hitzbleck, Michael; Schafmayer, Clemens; Philipp, Mark] Univ Med Ctr Rostock, Dept Gen Visceral Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
C3 University of Rostock
RP Philipp, M (通讯作者)，Univ Med Ctr Rostock, Dept Gen Visceral Vasc & Transplantat Surg, Schillingallee 35, D-18057 Rostock, Germany.
EM mark.philipp@med.uni-rostock.de
OI Leuchter, Matthias/0000-0003-3178-5579
FU Projekt DEAL
FX Open access funding enabled and organized by Projekt DEAL.
CR Berger RL, 2013, J AM COLL SURGEONS, V217, P974, DOI 10.1016/j.jamcollsurg.2013.08.003
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   Hajian-Tilaki K, 2013, CASP J INTERN MED, V4, P627
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NR 17
TC 4
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2021
VL 29
IS 5
BP 759
EP 765
DI 10.1111/wrr.12948
EA JUN 2021
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA UK1FO
UT WOS:000659463800001
PM 34110077
OA hybrid
DA 2026-07-24
ER

PT J
AU Costa, ML
   Achten, J
   Bruce, J
   Tutton, E
   Petrou, S
   Lamb, SE
   Parsons, NR
AF Costa, Matthew L.
   Achten, Juul
   Bruce, Julie
   Tutton, Elizabeth
   Petrou, Stavros
   Lamb, Sarah E.
   Parsons, Nick R.
CA UK WOLLF Collaboration
TI Effect of Negative Pressure Wound Therapy vs Standard Wound Management
   on 12-Month Disability Among Adults With Severe Open Fracture of the
   Lower Limb The WOLLF Randomized Clinical Trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID ORTHOPEDIC TRAUMA; HEALTH; INFECTION; EUROQOL; SF-36
AB IMPORTANCE Open fractures of the lower limb occur when a broken bone penetrates the skin. There can be major complications from these fractures, which can be life-changing.
   OBJECTIVES To assess the disability, rate of deep infection, and quality of life in patients with severe open fracture of the lower limb treated with negative pressure wound therapy (NPWT) vs standard wound management after the first surgical debridement of the wound.
   DESIGN, SETTING, AND PARTICIPANTS Multicenter randomized trial performed in the UK Major Trauma Network, recruiting 460 patients aged 16 years or older with a severe open fracture of the lower limb from July 2012 through December 2015. Final outcome data were collected through November 2016. Exclusions were presentation more than 72 hours after injury and inability to complete questionnaires.
   INTERVENTIONS NPWT (n = 226) in which an open-cell solid foam or gauze was placed over the surface of the wound and connected to a suction pump, creating a partial vacuum over the dressing, vs standard dressings not involving application of negative pressure (n = 234). MAIN OUTCOMES AND MEASURES Disability Rating Index score (range, 0 [no disability] to 100 [completely disabled]) at 12 months was the primary outcome measure, with a minimal clinically important difference of 8 points. Secondary outcomes were complications including deep infection and quality of life (score ranged from 1 [best possible] to -0.59 [worst possible]; minimal clinically important difference, 0.08) collected at 3, 6, 9, and 12 months.
   RESULTS Among 460 patients who were randomized (mean age, 45.3 years; 74% men), 88% (374/427) of available study participants completed the trial. There were no statistically significant differences in the patients' Disability Rating Index score at 12 months (mean score, 45.5 in the NPWT group vs 42.4 in the standard dressing group; mean difference, -3.9 [95% CI, -8.9 to 1.2]; P = .13), in the number of deep surgical site infections (16 [7.1%] in the NPWT group vs 19 [8.1%] in the standard dressing group; difference, 1.0%[95% CI, -4.2% to 6.3%]; P = .64), or in quality of life between groups (difference in EuroQol 5-dimensions questionnaire, 0.02 [95% CI, -0.05 to 0.08]; Short Form-12 Physical Component Score, 0.5 [95% CI, -3.1 to 4.1] and Mental Health Component Score, -0.4 [95% CI, -2.2 to 1.4]).
   CONCLUSIONS AND RELEVANCE Among patients with severe open fracture of the lower limb, use of NPWT compared with standard wound dressing did not improve self-rated disability at 12 months. The findings do not support this treatment for severe open fractures.
C1 [Costa, Matthew L.; Bruce, Julie; Tutton, Elizabeth; Petrou, Stavros; Lamb, Sarah E.] Univ Warwick, Warwick Med Sch, Warwick Clin Trials Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
   [Costa, Matthew L.; Achten, Juul; Tutton, Elizabeth; Lamb, Sarah E.] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford OX3 9DU, England.
   [Costa, Matthew L.] Univ Hosp Coventry & Warwickshire NHS Trust, Coventry, W Midlands, England.
   [Parsons, Nick R.] Univ Warwick, Warwick Med Sch, Stat & Epidemiol Unit, Gibbet Hill Campus, Coventry, W Midlands, England.
C3 University of Warwick; University of Oxford; University of Warwick;
   University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford Trauma, Oxford OX3 9DU, England.
EM Matthew.costa@ndorms.ox.ac.uk
RI Parsons, Nick/AAA-8713-2019; Petrou, Stavros/ABD-8323-2021; Bruce,
   Julie/G-7588-2014; Achten, Juul/KUD-8515-2024
OI Parsons, Nick/0000-0001-9975-888X; Petrou, Stavros/0000-0003-3121-6050;
   Tutton, Elizabeth/0000-0003-3973-360X; Costa,
   Matthew/0000-0003-3644-1388; Lamb, Sarah/0000-0003-4349-7195; Bruce,
   Julie/0000-0002-8462-7999; Achten, Juul/0000-0002-8857-5743
FU UK NIHR HTA Programme [10/57/20]; NIHR Oxford Biomedical Research
   Centre; NIHR Collaboration for Leadership in Applied Health Research and
   Care in Oxford; Smith Nephew; KCI Medical; Economic and Social Research
   Council [1499410] Funding Source: researchfish; Medical Research Council
   [G0501681, G0700452] Funding Source: researchfish; National Institute
   for Health Research [NF-SI-0616-10103, 10/57/20] Funding Source:
   researchfish; MRC [G0501681, G0700452] Funding Source: UKRI
FX This project was funded by the UK NIHR HTA Programme (project No.
   10/57/20) and was supported by the NIHR Oxford Biomedical Research
   Centre and the NIHR Collaboration for Leadership in Applied Health
   Research and Care in Oxford. The 2 main commercial entities (Smith &
   Nephew and KCI Medical) in this sector funded the excess treatment costs
   of the negative pressure wound therapy dressings but had no part in the
   design, conduct, or reporting of the trial.
CR Achten J, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009087
   [Anonymous], 2024, R: A language and environment for statistical computing
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   Brazier J, 2002, J HEALTH ECON, V21, P271, DOI 10.1016/S0167-6296(01)00130-8
   British Orthopaedic Association; British Association of Plastic Reconstructive and Aesthetic Surgeons, 2009, STAND TRAUM BOAST
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   White IR, 2011, STAT MED, V30, P377, DOI 10.1002/sim.4067
NR 24
TC 133
Z9 160
U1 0
U2 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 12
PY 2018
VL 319
IS 22
BP 2280
EP 2288
DI 10.1001/jama.2018.6452
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GJ2UP
UT WOS:000435129300014
PM 29896626
OA Green Accepted, Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Isath, A
   Gregory, V
   Ohira, S
   Levine, A
   Dhand, A
   Laskowski, I
   Mateo, R
   Babu, S
   Spielvogel, D
   Kai, MSS
AF Isath, Ameesh
   Gregory, Vasiliki
   Ohira, Suguru
   Levine, Avi
   Dhand, Abhay
   Laskowski, Igor
   Mateo, Romeo
   Babu, Sateesh
   Spielvogel, David
   Kai, Masashi
TI Groin wound management after decannulation of veno-arterial
   extracorporeal membrane oxygenation in heart transplantation: Role of
   sartorius muscle flap
SO CLINICAL TRANSPLANTATION
LA English
DT Article
DE heart transplant; Sartorius; VA-ECMO; wound complications
ID CANNULATION; OUTCOMES
AB BackgroundThe management of complex groin wounds following VA-ECMO after heart transplant (HT) is uncertain due to limited experience. Sartorius muscle flaps (SMF) have been used in vascular surgery for groin wound complications. However, their use in HT recipients with perioperative VA-ECMO is unclear. This study aims to describe characteristics and outcomes of HT patients with groin complications after arterial decannulation for femoral VA-ECMO.MethodsWe retrospectively reviewed HT patients who underwent peri-transplant femoral VA-ECMO at our institution from April 2011 to February 2023. Patients were categorized into two groups based on the presence of cannulation-related wound complications.ResultsAmong the 34 patients requiring VA-ECMO peri-transplant, 17 (50%) experienced complications at the cannulation site. Baseline characteristics including duration of VA-ECMO support were comparable in both groups. Patients with complications presented mostly with open wounds (41.1%) after a median duration of 22 days post-transplant. Concurrent groin infections were observed in 52.3% of patients, all caused by gram-negative bacteria.Wound complications were managed with 12 (70.6%) undergoing SMF treatment and 5 (31.2%) receiving conventional therapy. Four SMF recipients had preemptive procedures for wound dehiscence, while eight underwent SMF for groin infections. Among the SMF group, 11 patients had favorable outcomes without recurrent complications, except for one patient who developed a groin infection with pseudoaneurysm formation. Conventional therapy with vacuum assisted closure (VAC) and antibiotics were utilized in four patients without infection and one patient with infection. Three patients required additional surgeries with favorable healing of the wound.ResultsAmong the 34 patients requiring VA-ECMO peri-transplant, 17 (50%) experienced complications at the cannulation site. Baseline characteristics including duration of VA-ECMO support were comparable in both groups. Patients with complications presented mostly with open wounds (41.1%) after a median duration of 22 days post-transplant. Concurrent groin infections were observed in 52.3% of patients, all caused by gram-negative bacteria.Wound complications were managed with 12 (70.6%) undergoing SMF treatment and 5 (31.2%) receiving conventional therapy. Four SMF recipients had preemptive procedures for wound dehiscence, while eight underwent SMF for groin infections. Among the SMF group, 11 patients had favorable outcomes without recurrent complications, except for one patient who developed a groin infection with pseudoaneurysm formation. Conventional therapy with vacuum assisted closure (VAC) and antibiotics were utilized in four patients without infection and one patient with infection. Three patients required additional surgeries with favorable healing of the wound.ConclusionComplications related to femoral VA-ECMO are common in HT patients, with infection being the most frequent complication. SMFs can be a useful tool to prevent progression of infection and improve local healing.
C1 [Isath, Ameesh; Levine, Avi] Westchester Med Ctr, Dept Cardiol, Valhalla, NY USA.
   [Gregory, Vasiliki] New York Med Coll, Valhalla, NY USA.
   [Ohira, Suguru; Spielvogel, David] Westchester Med Ctr, Dept Surg, Div Cardiothorac Surg, Valhalla, NY USA.
   [Dhand, Abhay] Westchester Med Ctr, Dept Med, Transplant Infect Dis, Valhalla, NY USA.
   [Laskowski, Igor; Mateo, Romeo; Babu, Sateesh] Westchester Med Ctr, Dept Surg, Div Vasc Surg, Valhalla, NY USA.
   [Kai, Masashi] Beth Israel Deaconess Med Ctr, Div Cardiac Surg, Boston, MA USA.
   [Ohira, Suguru] New York Med Coll, Westchester Med Ctr, Div Cardiothorac Surg, 100 Woods Rd, Valhalla, NY 10595 USA.
C3 Westchester Medical Center; New York Medical College; Westchester
   Medical Center; Westchester Medical Center; Westchester Medical Center;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Westchester Medical Center; New York Medical
   College
RP Ohira, S (通讯作者)，New York Med Coll, Westchester Med Ctr, Div Cardiothorac Surg, 100 Woods Rd, Valhalla, NY 10595 USA.
EM suguru.ohira@wmchealth.org
RI ; Isath, Ameesh/GPK-5434-2022; Ohira, Suguru/AEH-8009-2022
OI Dhand, Abhay/0000-0003-3527-1938; 
CR Castro R, 2020, J CARDIAC SURG, V35, P3585, DOI 10.1111/jocs.15012
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   Kittleson MM, 2011, J HEART LUNG TRANSPL, V30, P1250, DOI 10.1016/j.healun.2011.05.006
   Mastoris I, 2022, CIRC-HEART FAIL, V15, DOI 10.1161/CIRCHEARTFAILURE.121.008777
   Ohira S, 2023, CLIN TRANSPLANT, V37, DOI 10.1111/ctr.14871
   Ohira S, 2021, JTCVS TECHNIQUES, V5, P62, DOI 10.1016/j.xjtc.2020.10.035
   Pellenc Q, 2020, EUR J CARDIO-THORAC, V58, P371, DOI 10.1093/ejcts/ezaa039
   Price A, 2020, INT WOUND J, V17, P1669, DOI 10.1111/iwj.13449
   Raffa GM, 2019, ANN THORAC SURG, V107, P311, DOI 10.1016/j.athoracsur.2018.05.063
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   Smood B., 2022, J ARTIF ORGANS, V26, P119
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   Wallace AB, 2022, ANN VASC SURG, V78, P77, DOI 10.1016/j.avsg.2021.05.049
   Williams IM, 2003, EUR J VASC ENDOVASC, V25, P390, DOI 10.1053/ejvs.2002.1890
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NR 20
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0902-0063
EI 1399-0012
J9 CLIN TRANSPLANT
JI Clin. Transplant.
PD DEC
PY 2023
VL 37
IS 12
DI 10.1111/ctr.15147
EA SEP 2023
PG 7
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA GJ8F2
UT WOS:001072523300001
PM 37755149
OA Bronze
DA 2026-07-24
ER

PT J
AU Grande, R
   Fiori, G
   Russo, G
   Fioramonti, P
   Campagnol, M
   di Marzo, L
AF Grande, Raffaele
   Fiori, Giulia
   Russo, Giulia
   Fioramonti, Paolo
   Campagnol, Monica
   di Marzo, Luca
TI A multistage combined approach to promote diabetic wound healing in
   COVID-19 era
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE CLI; diabetes mellitus; non-healing ulcers; NPWT; PRP
ID PLATELET-RICH PLASMA; OZONE-THERAPY; SURGICAL REVASCULARIZATION; LEG
   ULCERS; FOOT; METALLOPROTEINASES; EFFICACY; CARE
AB When diabetes mellitus is not properly controlled with drugs and a healthy lifestyle, it exposes patients with advanced peripheral arterial disease or critical limb ischaemia (CLI) to the most serious complications, in particular lower limb ulcers. Surgical or endovascular treatments represent the first line of intervention; in addition, the adequate management of ulcers can guarantee not only a faster wound healing but also the improvement of the patient's prognosis. To speed up this process, negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), and other advanced moist wound dressing have been proposed. During Coronavirus disease 2019 (COVID-19) pandemic, many patients with CLI and diabetes mellitus had difficult access to advanced treatments with a significant reduction in life expectancy. We report the cases of patients with non-healing ulcers and CLI treated with an empiric multistage approach after successful endovascular revascularisation; the postoperative course was eventful in all patients, and foot ulcers are currently in an advanced state of healing. The association between adequate revascularisation, systemic anti-inflammatory, and antibiotic therapy with the multistage advanced medications ensures healing of ulcers, limb salvage, and improvement of patient prognosis.
C1 [Grande, Raffaele; Fiori, Giulia; Russo, Giulia; Fioramonti, Paolo; Campagnol, Monica; di Marzo, Luca] Sapienza Univ Rome, Dept Surg Pietro Valdoni, Rome, Italy.
C3 Sapienza University Rome
RP Grande, R (通讯作者)，Sapienza Univ Rome, Dept Surg Pietro Valdoni, Policlin Umberto I, Viale Policlin 151, I-00161 Rome, Italy.
EM raffaele.eia@alice.it
RI ; Grande, Raffaele/AAO-1388-2020
OI di Marzo, Luca/0000-0002-2956-6257; Fiori, Giulia/0009-0001-5062-4829;
   Grande, Raffaele/0000-0003-2873-0104
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NR 38
TC 5
Z9 5
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2020
VL 17
IS 6
BP 1863
EP 1870
DI 10.1111/iwj.13476
EA AUG 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA PE3BU
UT WOS:000561059400001
PM 32820598
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Vallini, V
   Rinaldi, E
   Mangano, L
   Modesti, L
   Ghelardini, P
   Roberts, AT
   Grazi, G
AF Vallini, Valerio
   Rinaldi, Elisabetta
   Mangano, Luciana
   Modesti, Luca
   Ghelardini, Piero
   Roberts, Anna Theresa
   Grazi, Giovanni
TI Multiple subcutaneous haematomas of the legs causing skin necrosis in an
   elderly patient affected by corticosteroid-induced skin atrophy: Case
   report and review of literature
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE compartment syndrome; corticosteroid-induced skin atrophy; porcine
   xenograft; skin necrosis
ID RHEUMATOID-ARTHRITIS; COLLAGEN-METABOLISM; LICHEN-SCLEROSUS;
   GLUCOCORTICOIDS; ABNORMALITIES; INHIBITORS; RECEPTOR; THERAPY; STRIAE
AB Corticosteroid-induced skin atrophy (CISA) consists of a thinning of the skin and subcutaneous tissues, representing the natural consequence of a prolonged glucocorticosteroids use, both systemic as well as topical. It is characterised by the loss of elasticity and skin thickness, associated with an increased skin fragility leading to ecchymoses, haematomas, and steroid purpura. The management of CISA is a challenge for physicians, as the pathology is reversible in a minimal percentage of cases and only after a short topical steroid or low-dose course therapy. Often wounds with large loss of substance represent the more common complication, after a surgical drainage which is often necessary. Skin necrosis with compartment syndrome of a leg is another potential risk for these patients. Here, we report a case of an elderly patient affected by multiple subcutaneous haematomas of the legs causing skin necrosis, arisen after the use of anticoagulants for a deep venous thrombosis. The patient was successfully treated with surgical drainage, negative pressure wound therapy (NPWT), and porcine xenograft with no complications. Finally, we discuss the evidence of the current literature on topic.
C1 [Vallini, Valerio; Rinaldi, Elisabetta; Mangano, Luciana; Ghelardini, Piero; Roberts, Anna Theresa; Grazi, Giovanni] Osped Santa Maria Maddalena, Azienda USL Toscana Nord Ovest, UO Med Interna, Pisa, Toscana, Italy.
   [Modesti, Luca] Osped Felice Lotti, Azienda USL Toscana Nord Ovest, UO Ortopedia, Pisa, Italy.
RP Vallini, V (通讯作者)，Osped Santa Maria Maddalena, Azienda USL Toscana Nord Ovest, UO Med Interna, Pisa, Toscana, Italy.
EM vvallini@gmail.com
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NR 57
TC 3
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 540
EP 546
DI 10.1111/iwj.13312
EA JAN 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000508800300001
PM 31972900
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Burkhart, RA
   Javed, AA
   Ronnekleiv-Kelly, S
   Wright, MJ
   Poruk, KE
   Eckhauser, F
   Makary, MA
   Cameron, JL
   Wolfgang, CL
   He, J
   Weiss, MJ
AF Burkhart, Richard A.
   Javed, Ammar A.
   Ronnekleiv-Kelly, Sean
   Wright, Michael J.
   Poruk, Katherine E.
   Eckhauser, Frederic
   Makary, Martin A.
   Cameron, John L.
   Wolfgang, Christopher L.
   He, Jin
   Weiss, Matthew J.
TI The use of negative pressure wound therapy to prevent post-operative
   surgical site infections following pancreaticoduodenectomy
SO HPB
LA English
DT Article
ID PREOPERATIVE BILIARY DRAINAGE; PANCREATIC-CANCER; ADJUVANT CHEMOTHERAPY;
   COMPLICATIONS; OUTCOMES; FAILURE; FISTULA; SURGERY; BURDEN; HERNIA
AB Background: Rates of superficial surgical site infection (SSI) following pancreaticoduodenectomy remain high. Following resection for cancer, complications such as SSI impact adjuvant therapy delivery and portend worse survival. An incisional negative pressure dressing (iVAC) has been demonstrated to reduce SSI in other high-risk cohorts.
   Methods: Following a comprehensive effort to identify patients at high risk for SSI, the practice patterns at a single academic center shifted and iVAC use increased. SSI rates were tracked in a prospectively maintained database and are reported.
   Results: 394 patients underwent pancreaticoduodenectomy over 21 months. 120 patients (30.5%) had an iVAC applied. The overall rate of SSI was 19.8%. On multivariate analysis, increased risk for SSI was associated with neoadjuvant therapy, preoperative biliary interventions and prior abdominal surgery. iVAC use decreased the rate of SSI (OR 0.45, p = 0.015). In the highest-risk patients, SSI rate declined from 50% in patients without an iVAC to 19.1% with iVAC use (p = 0.015).
   Conclusion: The use of an iVAC following pancreaticoduodenectomy is associated with decreased SSI rates. This is particularly true for patients at highest risk as defined by a previously established risk scoring system in patients undergoing open pancreaticoduodenectomy.
C1 [Burkhart, Richard A.; Javed, Ammar A.; Ronnekleiv-Kelly, Sean; Wright, Michael J.; Poruk, Katherine E.; Eckhauser, Frederic; Makary, Martin A.; Cameron, John L.; Wolfgang, Christopher L.; He, Jin; Weiss, Matthew J.] Johns Hopkins Univ Hosp, Dept Surg, Halsted 608,600 N Wolfe St, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins Medicine
RP Weiss, MJ (通讯作者)，Johns Hopkins Univ Hosp, Dept Surg, Halsted 608,600 N Wolfe St, Baltimore, MD 21287 USA.
EM mweiss5@jhmi.edu
RI Wolfgang, Christopher/HGD-0863-2022; Javed, Ammar/AAE-2870-2020
OI Wright, Michael/0000-0003-3353-6664; He, Jin/0000-0001-9149-2247; Javed,
   Ammar/0000-0002-5463-5250
FU NIH [5T32CA126607-08]; Drs. Keith and Valda Kaye Research Fund
FX Funding for this study was in part provided by NIH grant 5T32CA126607-08
   (RAB). It is also with deep appreciation that these authors wish to
   thank the Drs. Keith and Valda Kaye Research Fund.
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NR 28
TC 43
Z9 46
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1365-182X
EI 1477-2574
J9 HPB
JI HPB
PD SEP
PY 2017
VL 19
IS 9
BP 825
EP 831
DI 10.1016/j.hpb.2017.05.004
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA FG9VQ
UT WOS:000410788400011
PM 28602643
OA Bronze
DA 2026-07-24
ER

PT J
AU Goldman, AH
   Tetsworth, K
AF Goldman, Ashton H.
   Tetsworth, Kevin
TI AAOS Clinical Practice Guideline Summary: Prevention of Surgical Site
   Infection After Major Extremity Trauma
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Article
ID OPEN FRACTURES; CLASSIFICATION
AB Prevention of Surgical Site Infections After Major Extremity Trauma Evidence-Based Clinical Practice Guideline is based on a systematic review of current scientific and clinical research. This clinical practice guideline (CPG) is designed to assist qualified physicians and clinicians when making treatment decisions for adults (18 years or older) who have sustained major extremity trauma. The CPG workgroup defined major extremity trauma as an open fracture, a major/high-energy closed fracture, a degloving injury, Morel-Lavallee lesions, a low-energy or high-energy gunshot injury, a crush injury, a blast injury, or any other moderate-energy to high-energy injury. This guideline contains 14 recommendations that evaluate preoperative, perioperative, and postoperative interventions to limit the risk of surgical site infections after major extremity trauma while also identifying and evaluating potential patient-specific risk factors to consider. Another six options formulated with either low-quality evidence, no evidence, or conflicting evidence are also presented and discussed in the CPG. These include the use of incisional negative-pressure wound therapy for high-risk surgical incisions, the implementation of an orthoplastic team, the possible role of hyperbaric O-2, the value of various preoperative skin preparations, and select modifiable and administrative risk factors.
C1 [Goldman, Ashton H.] Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
   [Goldman, Ashton H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Tetsworth, Kevin] Royal Brisbane & Womens Hosp, Brisbane, Australia.
   [Tetsworth, Kevin] Univ Queensland, Sch Med Brisbane, Brisbane, Australia.
C3 United States Department of Defense; United States Navy; Uniformed
   Services University of the Health Sciences - USA; Royal Brisbane &
   Women's Hospital; University of Queensland
RP Goldman, AH (通讯作者)，Naval Med Ctr Portsmouth, Portsmouth, VA 23708 USA.; Goldman, AH (通讯作者)，Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
EM ashton.goldman@gmail.com; ktetsworthmd@gmail.com
RI ; Tetsworth, Kevin/A-8005-2013
OI Goldman, Ashton/0000-0003-4481-9707; 
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NR 16
TC 24
Z9 32
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JAN 1
PY 2023
VL 31
IS 1
BP E1
EP E8
DI 10.5435/JAAOS-D-22-00792
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 7G3DT
UT WOS:000902410300001
PM 36548150
DA 2026-07-24
ER

PT J
AU Lonneman, MK
   Pumiglia, L
   Zhang, B
   Edinger, AA
   Dejong, J
   Akinmoladun, OO
   Van Eaton, JC
   Kelly, A
   Dolezal, K
   Enzerink, A
   Glaser, JJ
   Bingham, JR
   Oliver, J
AF Lonneman, M. K.
   Pumiglia, L.
   Zhang, B.
   Edinger, A. A.
   Dejong, J.
   Akinmoladun, O. O.
   Van Eaton, J. C.
   Kelly, A.
   Dolezal, K.
   Enzerink, A.
   Glaser, J. J.
   Bingham, J. R.
   Oliver, J.
TI "Sucking the trouble" out of troubleshooting wound vacs: Video based
   curriculum development and implementation in a live tissue model
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
ID AEROMEDICAL EVACUATION; THERAPY; EDUCATION
AB We hypothesized that non-surgeon, Negative Pressure Wound Therapy (NPWT) na & iuml;ve participants would better identify device functions and troubleshoot failures after being exposed to a video curriculum (VC) compared to similar participants exposed to clinical practice guidelines (CPGs). VC and critical action step development was followed by randomization of 115 non-surgical, NPWT na & iuml;ve participants into either the CPG or VC study groups. Participants individually identified components of the NPWT system and then worked as a team to troubleshoot three scenarios on an in vivo porcine model. VC participants better identified all NPWT components and functions (p < 0.001), demonstrated correct cannister attachment (p < 0.001) and performed a seal check (p < 0.001). VC teams performed more critical action steps in the leak (p = 0.011) and obstruction (p = 0.001) scenarios. In post-event surveys, participants were more likely to find the VC easy to use and informative and were likely to recommend the videos to a colleague (p = 0.008, p = 0.019, p = 0.02). VC participants demonstrated improved competency in individual NPWT component identification and team-based troubleshooting of NPWT failures. This VC represents an effective alternative to existing CPGs.
C1 [Lonneman, M. K.; Pumiglia, L.; Zhang, B.; Edinger, A. A.; Dejong, J.; Akinmoladun, O. O.; Van Eaton, J. C.; Kelly, A.; Dolezal, K.; Enzerink, A.; Glaser, J. J.; Bingham, J. R.; Oliver, J.] Madigan Army Med Ctr, 9040A Jackson Ave, Joint Base Lewis Mcchord, WA 98431 USA.
C3 Madigan Army Medical Center
RP Lonneman, MK (通讯作者)，Madigan Army Med Ctr, 9040A Jackson Ave, Joint Base Lewis Mcchord, WA 98431 USA.
EM mklonneman@gmail.com
RI ; Bingham, Jason/N-6822-2019; Glaser, Jacob/PKG-6438-2026
OI Zhang, Bobby/0009-0001-7771-1981; 
FU The 59th Medical Wing
FX This work was supported by the 59th Medical Wing with administrative
   support provided by the Geneva Foundation.
CR Al-Elq AH, 2010, J FAM COMMUNITY MED, V17, P35, DOI 10.4103/1319-1683.68787
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NR 23
TC 0
Z9 0
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2025
VL 243
AR 116244
DI 10.1016/j.amjsurg.2025.116244
EA FEB 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA Y0A4O
UT WOS:001428860900001
PM 39956036
DA 2026-07-24
ER

PT J
AU Tabley, A
   Aludaat, C
   Le Guillou, V
   Gay, A
   Nafeh-Bizet, C
   Scherrer, V
   Bouchart, F
   Doguet, F
AF Tabley, Alfred
   Aludaat, Chadi
   Le Guillou, Vincent
   Gay, Arnaud
   Nafeh-Bizet, Catherine
   Scherrer, Vincent
   Bouchart, Francois
   Doguet, Fabien
TI A Survey of Cardiac Surgery Infections With PICO Negative Pressure
   Therapy in High-Risk Patients
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID WOUND THERAPY; COMPLICATIONS; COST
AB Background. Surgical site complications represent major concerns in many surgical specialties and lead to an increased length of hospital stay and the need for additional treatments and care. This investigation aimed to report survey data from the introduction of the PICO negative pressure wound therapy system (Smith & Nephew, Hull, United Kingdom) in a single hospital in France regarding cardiac surgical procedures through standard median sternotomy.
   Methods. The patients in this study were at high risk of developing surgical site infections. PICO was used immediately postoperatively on the closed incision sites in all patients undergoing cardiac surgical procedures. Data were compared with a retrospective cohort of patients in whom PICO had not been used postoperatively. In total, 233 anonymized patient records were reviewed, 142 of which used the PICO device and 91 of which did not.
   Results. PICO was shown to provide both clinical and economic benefits over standard care across a range of different cardiac surgical patients. The rates of complications, including deep surgical wound infections and mediastinitis, were reduced.
   Conclusions. As noted, PICO had advantages over standard care in these patients, and complication rates decreased. This study demonstrated cost savings and an increase in available surgical and hospital capacity related to PICO use. (C) 2020 by The Society of Thoracic Surgeons
C1 [Tabley, Alfred; Aludaat, Chadi; Le Guillou, Vincent; Gay, Arnaud; Nafeh-Bizet, Catherine; Bouchart, Francois; Doguet, Fabien] Rouen Univ Hosp, Dept Cardiovasc & Thorac Surg, 1 Rue Germount, F-76000 Rouen, France.
   [Scherrer, Vincent] Rouen Univ Hosp, Dept Anesthesia & Crit Care, Rouen, France.
   [Doguet, Fabien] Univ Rouen, Normandy Univ, Natl Inst Med Res Unit 1096, Rouen, France.
C3 Centre Hospitalier du Rouvray; Universite de Rouen Normandie; CHU de
   Rouen; Centre Hospitalier du Rouvray; Universite de Rouen Normandie; CHU
   de Rouen; Universite de Rouen Normandie
RP Tabley, A (通讯作者)，Rouen Univ Hosp, Dept Cardiovasc & Thorac Surg, 1 Rue Germount, F-76000 Rouen, France.
EM atabley@gmail.com
RI /ABI-4799-2020
OI aludaat, chadi/0000-0002-9825-3852
CR Berg TC, 2011, EUR J CARDIO-THORAC, V40, P1291, DOI 10.1016/j.ejcts.2011.02.038
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NR 17
TC 18
Z9 21
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2020
VL 110
IS 6
BP 2034
EP 2040
DI 10.1016/j.athoracsur.2020.03.087
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA OT4YH
UT WOS:000590853100066
PM 32371085
OA Bronze
DA 2026-07-24
ER

PT J
AU Jiang, YY
   Ni, JD
   Zhang, L
   Jiang, LJ
   Li, X
AF Jiang, Yangyang
   Ni, Jindi
   Zhang, Lu
   Jiang, Lijing
   Li, Xiang
TI Refractory abdominal compartment syndrome secondary to ruptured
   abdominal aortic aneurysm treated with total colectomy and upper rectal
   resection: A case report and literature review
SO MEDICINE
LA English
DT Article
DE abdominal compartment syndrome; multiple organ dysfunction syndrome;
   ruptured abdominal aortic aneurysm
ID RISK-FACTORS; REPAIR; DIAGNOSIS
AB Rationale:Ruptured abdominal aortic aneurysm (RAAA) is a critical condition often complicated by multiple organ dysfunction syndrome (MODS), which can significantly impede recovery following surgical intervention. Abdominal compartment syndrome (ACS) is a widely recognized but highly lethal postoperative complication.Patient concerns:A 69-year-old male presented with acute abdominal pain and hemorrhagic shock.Diagnoses:RAAA with active extravasation was confirmed, and following surgical repair, the patient developed MODS, including hepatorenal failure and acute respiratory distress syndrome. Twenty-one days postoperatively, secondary ACS led to colonic ischemia.Interventions:The patient was managed using staged surgical interventions, including decompressive laparotomy, negative pressure wound therapy systems, and definitive total colectomy with upper rectal resection due to refractory ACS characterized by transmural colonic necrosis.Outcomes:The patient showed significant recovery and was discharged after 81 days of hospitalization. At 1-month follow-up, he reported normal oral intake and no recurrence of major complications.Lessons:This case illustrates the effectiveness of a phased damage control strategy in managing high-risk RAAA patients, demonstrating that early prediction, timely intervention, and multidisciplinary care can significantly improve survival outcomes.
C1 [Jiang, Yangyang; Ni, Jindi; Zhang, Lu; Jiang, Lijing; Li, Xiang] Fudan Univ, Minhang Hosp, Dept Crit Care Med, 39 Xinling Rd, Shanghai 201199, Peoples R China.
C3 Fudan University
RP Li, X (通讯作者)，Fudan Univ, Minhang Hosp, Dept Crit Care Med, 39 Xinling Rd, Shanghai 201199, Peoples R China.
EM jyy009009@126.com; nijindi_mh@fudan.edu.cn; 18231360063@fudan.edu.cn;
   lijing_jiang@fudan.edu.cn; xiangli_mh@fudan.edu.cn
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 24
PY 2026
VL 105
IS 17
AR e48285
DI 10.1097/MD.0000000000048285
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB7XN
UT WOS:001750295700013
PM 42071870
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dawi, J
   Tumanyan, K
   Tomas, K
   Misakyan, Y
   Gargaloyan, A
   Gonzalez, E
   Hammi, M
   Tomas, S
   Venketaraman, V
AF Dawi, John
   Tumanyan, Kevin
   Tomas, Kirakos
   Misakyan, Yura
   Gargaloyan, Areg
   Gonzalez, Edgar
   Hammi, Mary
   Tomas, Serly
   Venketaraman, Vishwanath
TI Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and
   Emerging Therapeutic Strategies
SO BIOMEDICINES
LA English
DT Review
DE advanced glycation end products (AGEs); receptor for AGEs (RAGE)
   activation; macrophage polarization (M1/M2 imbalance); vascular
   endothelial growth factor (VEGF) therapy; negative pressure wound
   therapy (NPWT)
ID OXIDATIVE STRESS; WOUND CARE; MANAGEMENT; PATHOGENESIS; INFLAMMATION;
   SOCIETY; CELLS
AB Diabetic foot ulcers (DFUs) are among the most common and debilitating complications of diabetes mellitus (DM), affecting approximately 15-25% of patients and contributing to over 85% of non-traumatic amputations. DFUs impose a substantial clinical and economic burden due to high recurrence rates, prolonged wound care, and frequent hospitalizations, accounting for billions in healthcare costs worldwide. The multifactorial pathophysiology of DFUs involves peripheral neuropathy, peripheral arterial disease, chronic inflammation, and impaired tissue regeneration. Recent studies underscore the importance of immune dysregulation-specifically macrophage polarization imbalance, regulatory T cell dysfunction, and neutrophil impairment-as central mechanisms in wound chronicity. These immune disruptions sustain a pro-inflammatory environment dominated by cytokines, such as TNF-alpha, IL-1 beta, and IL-6, which impair angiogenesis and delay repair. This review provides an updated synthesis of DFU pathogenesis, emphasizing immune dysfunction and its therapeutic implications. We examine emerging strategies in immunomodulation, regenerative medicine, and AI-based wound technologies, including SGLT2 inhibitors, biologics, stem cell therapies, and smart dressing systems. These approaches hold promise for accelerating healing, reducing amputation risk, and personalizing future DFU care.
C1 [Dawi, John; Misakyan, Yura; Gargaloyan, Areg; Gonzalez, Edgar; Hammi, Mary; Venketaraman, Vishwanath] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
   [Tumanyan, Kevin; Tomas, Kirakos] Western Univ Hlth Sci, Coll Podiatr Med, Pomona, CA 91766 USA.
   [Tomas, Serly] Oakland Univ, William Beaumont Sch Med, Rochester, MI 48309 USA.
C3 Western University of Health Sciences; Western University of Health
   Sciences; Oakland University
RP Venketaraman, V (通讯作者)，Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
EM john.dawi@westernu.edu; kevin.tumanyan@westernu.edu;
   kirakos.tomas@westernu.edu; yura.misakyan@westernu.edu;
   areg.gargaloyan@westernu.edu; edgar.gonzalez@westernu.edu;
   mary.hammi@westernu.edu; stomas@oakland.edu; vvenketaraman@westernu.edu
RI ; venketaraman, Vishwanath/AAW-6945-2020
OI Dawi, John/0009-0002-1860-3697; venketaraman,
   Vishwanath/0000-0002-2586-1160
FU NIH-NHLBI;  [2R15HL143545-02]
FX We appreciate the funding support from the NIH-NHLBI (2R15HL143545-02).
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   Sun D, 2024, J TISSUE ENG, V15, DOI 10.1177/20417314241265202
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   Ul Hassan W, 2014, WOUND REPAIR REGEN, V22, P313, DOI 10.1111/wrr.12173
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   Wang Y, 2024, REGEN BIOMATER, V11, DOI 10.1093/rb/rbae032
   Weigelt C, 2009, DIABETES CARE, V32, P1491, DOI 10.2337/dc08-2318
   Wilkinson HN, 2019, J INVEST DERMATOL, V139, P1171, DOI 10.1016/j.jid.2019.01.005
   Wolf SJ, 2021, SEMIN CELL DEV BIOL, V119, P111, DOI 10.1016/j.semcdb.2021.06.013
   Wounds, 2023, International Best Practice Statement: Biofilm Management-Moving Forward
   Wu XQ, 2022, BURNS TRAUMA, V10, DOI 10.1093/burnst/tkac051
   Yang BW, 2023, BURNS TRAUMA, V11, DOI 10.1093/burnst/tkad039
   Zhang PZ, 2017, ANN MED, V49, P106, DOI 10.1080/07853890.2016.1231932
   Zhang XL, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.023800
   Zhou K., 2024, Endotext.org
NR 68
TC 120
Z9 139
U1 54
U2 73
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD APR 29
PY 2025
VL 13
IS 5
AR 1076
DI 10.3390/biomedicines13051076
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 3BP9F
UT WOS:001496465400001
PM 40426903
OA Green Submitted, gold
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Weir, G
AF Weir, Gregory
TI The use of a surgical incision management system on vascular surgery
   incisions: a pilot study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE SIM; Surgical incision management; Surgical site infection; Vascular
   surgery
ID INFECTIONS
AB Health care-associated infections in hospitals, including surgical site infections, contribute significantly to morbidity as well as mortality. Surgical incision management (SIM) using negative pressure wound therapy (Prevena (TM) Incision Management System, Kinetic Concepts, Inc., San Antonio, TX, USA) is designed to cover and protect closed surgical incisions from external factors including infectious sources and local trauma, while negative pressure removes fluid and infectious material from the surgical incision. A prospective case-control study assessed wound complications in patients undergoing vascular bypass procedures, where both femoral areas were incised to gain access to the femoral arteries. SIM was placed on one femoral area while a standard postoperative wound dressing was placed on the contralateral femoral area. Eight patients were included in this pilot study. All of them required bilateral femoral artery access. During the follow-up period patients were monitored for wound complications. All wound complications requiring surgical intervention were considered significant. No significant wound complications occurred in wounds treated with SIM, compared with three significant complications in control wounds. These preliminary data would suggest a potential reduction in wound complications and no observed increase in haemorrhage in high-risk patients with severe co-morbidities undergoing vascular surgery.
C1 Eugene Marais Hosp, Vasc & Hyperbar Unit, Pretoria, South Africa.
RP Weir, G (通讯作者)，Eugene Marais Hosp, Vasc & Hyperbar Unit, POB 26091, Pretoria, South Africa.
EM gweir@vascular.co.za
CR [Anonymous], 2010, HLTH CARE ACQUIRED I
   Klevens RM, 2007, PUBLIC HEALTH REP, V122, P160, DOI 10.1177/003335490712200205
   Scott R.D., 2009, The direct medical costs of healthcare associated infections in US hospitals and the benefits of prevention
   1996, AM J INFECT CONTROL, V24, P380
NR 4
TC 15
Z9 16
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 10
EP 12
DI 10.1111/iwj.12261
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900004
PM 24851730
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Rasilainen, SK
   Mentula, PJ
   Leppäniemi, AK
AF Rasilainen, S. K.
   Mentula, P. J.
   Leppaniemi, A. K.
TI Components separation technique is feasible for assisting delayed
   primary fascial closure of open abdomen
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Open abdomen; primary fascial closure; components separation; abdominal
   compartment syndrome; temporary abdominal closure; vacuum-assisted wound
   closure
ID ABDOMINAL-WALL DEFECTS; INTRAABDOMINAL HYPERTENSION; STAGED MANAGEMENT;
   CRITICALLY-ILL; HERNIA; RECONSTRUCTION; VACUUM; MESH; TRACTION; OUTCOMES
AB Background and aims: The goal after open abdomen treatment is to reach primary fascial closure. Modern negative pressure wound therapy systems are sometimes inefficient for this purpose. This retrospective chart analysis describes the use of the components separation' method in facilitating primary fascial closure after open abdomen.
   Material and methods: A total of 16 consecutive critically ill surgical patients treated with components separation during open abdomen management were analyzed. No patients were excluded.
   Results: Primary fascial closure was achieved in 75% (12/16). Components separation was performed during ongoing open abdomen treatment in 7 patients and at the time of delayed primary fascial closure in 9 patients. Of the former, 3/7 (43%) patients reached primary fascial closure, whereas all 9 patients in the latter group had successful fascial closure without major complications (p=0.019).
   Conclusion: Components separation is a useful method in contributing to successful primary fascial closure in patients treated for open abdomen. Best results were obtained when components separation was performed simultaneously with primary fascial closure at the end of the open abdomen treatment.
C1 [Rasilainen, S. K.] Jorvi Hosp, Dept Abdominal Surg, SF-02740 Espoo, Finland.
   [Mentula, P. J.; Leppaniemi, A. K.] Univ Helsinki, Cent Hosp, Dept Abdominal Surg, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Rasilainen, SK (通讯作者)，Pihlajatie 6A,POB 02270, Espoo, Finland.
EM rasilainensuvi@gmail.com
RI Mentula, Panu/H-9025-2019; Leppäniemi, Ari/GQZ-7991-2022
OI Mentula, Panu/0000-0002-6516-3797; 
FU Helsinki University Hospital
FX This study was financially supported only by a Helsinki University
   Hospital research grant for emergency abdominal surgery.
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NR 29
TC 18
Z9 19
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD MAR
PY 2016
VL 105
IS 1
BP 17
EP 21
DI 10.1177/1457496915586651
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DH5LI
UT WOS:000372830000004
PM 25972489
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Leaper, D
   Ousey, K
AF Leaper, David
   Ousey, Karen
TI Evidence update on prevention of surgical site infection
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE antibiotic prophylaxis; antimicrobial sutures; antiseptics; surgical
   dressings; surgical site infection
ID TRICLOSAN-COATED SUTURES; EDGE PROTECTION DEVICES; PRESSURE WOUND
   THERAPY; ANTIBIOTIC-PROPHYLAXIS; RISK; SURGERY; TRIAL; SURVEILLANCE;
   METAANALYSIS
AB Purpose of review
   Surgical site infection (SSI) is a common healthcare-associated infection and complicates up to 10-20% of operations with considerable strain on healthcare resources. Apart from the widely adopted use of appropriate hair removal, antibiotic prophylaxis, avoidance of hypothermia and perioperative glycaemic control to reduce SSIs, this review has considered new research and systematic reviews, and whether their findings should be included in guidelines.
   Recent findings
   The efficacy of preoperative bathing/showering, antibiotic prophylaxis for clean surgery and perioperative oxygen supplementation to reduce the risk of SSI is still in doubt. By contrast, the use of 2% chlorhexidine in alcohol skin preparation, postoperative negative pressure wound therapy and antiseptic surgical dressings do show promise. Antimicrobial sutures in independent meta-analyses were found to reduce the risk of SSI after all classes of surgery (except dirty) whereas the use of wound guards, or diathermy skin incision (compared with scalpel incision), did not.
   Summary
   The incidence of SSI after surgery is not falling. Based on this review of published trials and evidence-based systematic reviews some advances might be included into these care bundles. More research is needed together with improved compliance with care bundles.
C1 [Leaper, David; Ousey, Karen] Univ Huddersfield, Sch Human & Hlth Sci, Inst Skin Integr & Infect Prevent, Huddersfield HD1 3DH, W Yorkshire, England.
C3 University of Huddersfield
RP Leaper, D (通讯作者)，Univ Huddersfield, Sch Human & Hlth Sci, Inst Skin Integr & Infect Prevent, Huddersfield HD1 3DH, W Yorkshire, England.
EM profdavidleaper@doctors.org.uk
RI Ousey, Karen/W-1881-2018
OI Ousey, Karen/0000-0002-6993-9425
FU Johnson and Johnson; Smith and Nephew; Carefusion
FX In the last 5 years D.L. has acted in an advisory capacity or been
   supported financially in sponsored symposia for Ethicon (Johnson and
   Johnson), Smith and Nephew and Carefusion. K.O. has no conflicts of
   interest.
CR [Anonymous], 2012, English national point prevalence survey on healthcare associated infections and antimicrobial use, 2011: preliminary data
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NR 52
TC 69
Z9 89
U1 0
U2 50
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2015
VL 28
IS 2
BP 158
EP 163
DI 10.1097/QCO.0000000000000144
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA CE9EW
UT WOS:000352147700006
PM 25692267
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Baig, SJ
   Priya, P
AF Baig, Sarfaraz Jalil
   Priya, Pallawi
TI Complexities in the management of a Richter's supraumbilical hernia with
   colocutaneous fistula in a patient with morbid obesity: A case report
   with a review of literature
SO JOURNAL OF MINIMAL ACCESS SURGERY
LA English
DT Review
DE Colocutaneous fistula; enterocutaneous fistula; Richter's hernia
AB Abdominal wall Richter's hernia is rare. The usual presentation is with irreducibility, obstruction and strangulation. Occasionally, enterocutaneous fistula containing small bowel has been reported. Management is frequently difficult due to emergency presentation and contamination. A 60-year-old male with a history of suture repair of umbilical hernia presented with faecal discharge from a long-standing recurrent hernia in the background of obesity and history of pulmonary embolism. There were no features of peritonitis or obstruction. After optimisation, we took the patient for a diagnostic laparoscopy with curative intent. Diagnostic laparoscopy revealed a Richter's hernia containing transverse colon. The patient was treated with resection of the involved colonic segment, anastomosis, complete excision of the fistula tract along with surrounding skin, negative pressure wound therapy and delayed skin closure. To our knowledge, this is the first report of a spontaneous umbilical Richter's hernia complicated with a colocutaneous fistula. Management was challenging due to emergency presentation, multiple comorbidities as well as faecal contamination. Minimal access approach may have helped by decreasing the contamination and surgical site infection in the postoperative period.
C1 [Baig, Sarfaraz Jalil; Priya, Pallawi] Belle Vue Clin, Dept Minimal Access Surg & Surg Gastroenterol, Kolkata, W Bengal, India.
RP Priya, P (通讯作者)，Belle Vue Clin, Dept Minimal Access Surg & Surg Gastroenterol, Kolkata, W Bengal, India.
EM drpallawipriya@gmail.com
RI Baig, Sarfaraz/AAP-9320-2020
CR Chen W, 2017, BMC SURG, V17, DOI 10.1186/s12893-017-0216-z
   Cikman O, 2015, ABCD-ARQ BRAS CIR DI, V28, P152, DOI [10.1590/S0102-67202015000200019, 10.1590/s0102-67202015000200019]
   Earle DB, 2013, SURG CLIN N AM, V93, P1057, DOI 10.1016/j.suc.2013.06.017
   Elenwo SN, 2016, INT J SURG CASE REP, V20, P27, DOI 10.1016/j.ijscr.2016.01.003
   Rutkow IM, 2003, SURG CLIN N AM, V83, P1021, DOI 10.1016/S0039-6109(03)00131-2
NR 5
TC 1
Z9 1
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0972-9941
EI 1998-3921
J9 J MINIM ACCESS SURG
JI J. Minimal Access Surg.
PD APR-JUN
PY 2022
VL 18
IS 2
BP 308
EP 310
DI 10.4103/jmas.JMAS_99_21
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA D9LV2
UT WOS:000971879100025
PM 35313440
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ryan, E
AF Ryan, E.
TI The use of a micropore particle technology in the treatment of acute
   wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dehisced surgical wounds; Acapsil; pressure ulcer; wound healing;
   micropore particle technology; acute wounds
AB Objective: A clinical audit was performed to evaluate whether Acapsil micropore particle technology (MPPT) powder could improve the management of acute wounds to heal by secondary intention.
   Method: Wounds, which could be characterised as sloughy, wet and probably infected, normally managed by debridement followed by negative pressure wound therapy (NPWT), were included in the evaluation. The MPPT powder was applied topically to the wound surface either once daily or on alternate days, with each wound receiving a total of two to five applications. Most patients had NPWT after the MPPT powder treatment had finished to assist healing.
   Results: The study included nine patients with dehisced surgical wounds and one with a category IV pressure ulcer (PU). The wounds were generally covered in slough, exudate and showing signs of local infection. The topical MPPT powder rapidly desloughed the wounds, controlled exudate levels, promoted granulation and was well tolerated. All wounds proceeded towards closure.
   Conclusion: Comparison of the present data with MPPT powder to standard treatment suggests that the speed of healing using MPPT was improved. Further examination is required to determine if this reduces dressing changes, nursing time, and financial cost.
C1 [Ryan, E.] Bristol Royal Infirm & Gen Hosp, Bristol Univ Hosp, Upper Maudlin St, Bristol, Avon, England.
C3 Bristol Royal Infirmary
RP Ryan, E (通讯作者)，Bristol Royal Infirm & Gen Hosp, Bristol Univ Hosp, Upper Maudlin St, Bristol, Avon, England.
EM Ebony.Ryan@UHBristol.nhs.uk
CR Bilyayeva OO, WNDS201705253 WOUNDS
   Menke NB, 2007, CLIN DERMATOL, V25, P19, DOI 10.1016/j.clindermatol.2006.12.005
   Phillips PL, 2010, WOUNDS UK, V1
   Willingsford Healthcare, 2016, AC HOW IT WORKS
NR 4
TC 7
Z9 8
U1 1
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2017
VL 26
IS 7
BP 404
EP 413
DI 10.12968/jowc.2017.26.7.404
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA5IY
UT WOS:000405477800006
PM 28704154
DA 2026-07-24
ER

PT J
AU Fitzgerald, RH
   Bharara, M
   Mills, JL
   Armstrong, DG
AF Fitzgerald, Ryan H.
   Bharara, Manish
   Mills, Joseph L.
   Armstrong, David G.
TI Use of a Nanoflex powder dressing for wound management following
   debridement for necrotising fasciitis in the diabetic foot
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Wound healing; Diabetic foot; Nanoparticle; Dressing; Nanotechnology
AB This paper discusses the application of Nanoflex powder dressing for management of complex soft tissue wounds. A case report is presented detailing the management of a 43-year-old Native American woman with diabetes mellitus who required serial debridements for necrotising fasciitis. Following debridement, the patient was left with a large dorsal foot wound and was transitioned through multiple advanced wound healing modalities. Negative pressure wound therapy (NPWT) was initially utilised in the early postoperative setting to control drainage and to promote granulation tissue; the patient was subsequently transitioned to a Nanoflex powder dressing on postoperative day 4. She reported a decrease in pain associated with dressing changes when transitioned from NPWT to the use of Nanoflex powder dressing. We hypothesise that this pain reduction is the result of a light cooling effect of the exudate-controlling dressing and subsequent reduction in inflammation as well as the total contact nature of the dressing. Nanoflex powder dressings are a recently developed advanced wound healing modality with promise in the management of complex soft tissue wounds, both as a primary wound dressing as well as a delivery platform for analgesics, antimicrobials and pro-angiogenic compounds.
C1 [Fitzgerald, Ryan H.; Bharara, Manish; Mills, Joseph L.; Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, Tucson, AZ 85724 USA.
C3 University of Arizona
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, 1501 N Campbell Ave, Tucson, AZ 85724 USA.
EM armstrong@usa.net
RI Mills, Joseph/L-2023-2019
OI Mills, Joseph/0000-0002-4955-4384
CR [Anonymous], 2004, WOUNDS, p3S
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NR 21
TC 19
Z9 20
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2009
VL 6
IS 2
BP 133
EP 139
DI 10.1111/j.1742-481X.2009.00596.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BT
UT WOS:000207845800006
PM 19432662
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kiliçoglu, ÖI
   Demirel, M
   Aktas, S
AF Kilicoglu, Onder I.
   Demirel, Mehmet
   Aktas, Samil
TI New trends in the orthopaedic management of diabetic foot
SO EFORT OPEN REVIEWS
LA English
DT Article
DE diabetic foot; Charcot foot
ID PRESSURE WOUND THERAPY; METATARSAL HEAD RESECTION; HYPERBARIC-OXYGEN
   THERAPY; TIBIOTALOCALCANEAL ARTHRODESIS; CHARCOT NEUROARTHROPATHY;
   SURGICAL-MANAGEMENT; JOINT ARTHROPLASTY; PLANTAR PRESSURE; ULCER
   PREVENTION; GROWTH-FACTOR
AB Although there are various types of therapeutic footwear currently used to treat diabetic foot ulcers (DFUs), recent literature has enforced the concept that total-contact casts are the benchmark.
   Besides conventional clinical tests and imaging modalities, advanced MRI techniques and high-sensitivity nuclear medicine modalities present several advantages for the investigation of diabetic foot problems.
   The currently accepted principles of DFU care are rigorous debridement followed by modern wound dressings to provide a moist wound environment. Recently, hyperbaric oxygen and negative pressure wound therapy have aroused increasing attention as an adjunctive treatment for patients with DFUs.
   For DFU, various surgical treatments are currently available, including resection arthroplasty, metatarsal osteotomies and metatarsal head resections.
   In the modern management of the Charcot foot, surgery in the acute phase remains controversial and under investigation. While conventional fixation techniques are frequently insufficient to keep alignment postoperatively, superconstruct techniques could provide a successful fixation.
   Retrograde intramedullary nailing has been a generally accepted method of achieving stability. The midfoot fusion bolt is a current treatment device that maintains the longitudinal columns of the foot. Also, Achilles tendon lengthening remains a popular method in the management of Charcot foot.
C1 [Kilicoglu, Onder I.; Demirel, Mehmet] Istanbul Univ, Istanbul Fac Med, Dept Orthopaed & Traumatol, Istanbul, Turkey.
   [Aktas, Samil] Istanbul Univ, Istanbul Fac Med, Dept Underwater & Hyperbar Med, Istanbul, Turkey.
C3 Istanbul University; Istanbul University
RP Kiliçoglu, ÖI (通讯作者)，Istanbul Univ, Istanbul Fac Med, Millet Cad 118, TR-34093 Istanbul, Turkey.
EM onder.kilicoglu@gmail.com
RI Kılıçoğlu, Önder İsmet/B-2810-2011; /AAD-6656-2020; demirel,
   mehmet/AAN-7795-2020
OI Kılıçoğlu, Önder İsmet/0000-0003-0023-7094; demirel,
   mehmet/0000-0003-1131-7719
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NR 100
TC 8
Z9 13
U1 1
U2 23
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 2396-7544
EI 2058-5241
J9 EFORT OPEN REV
JI EFORT Open Rev.
PD MAY
PY 2018
VL 3
IS 5
BP 269
EP 277
DI 10.1302/2058-5241.3.170073
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GN3YR
UT WOS:000438949600016
PM 29951266
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gänzle, M
   Stöhr, M
   Dietz, A
AF Ganzle, Maximilian
   Stohr, Matthaus
   Dietz, Andreas
TI Difficult Wounds in the Head and Neck Area
SO LARYNGO-RHINO-OTOLOGIE
LA German
DT Article
DE NPWT; negative pressure wound therapy; wound healing; wound treatment;
   NPWT; negative pressure wound therapy; wound healing; wound treatment
ID COMPLICATIONS; EXPRESSION; CLOSURE; IMPACT; SKIN
AB Wound care in the head and neck region is particularly challenging due to its complex anatomy, functional significance, and aesthetic requirements. A careful approach that considers systemic and local factors, as well as consistent wound care, are crucial for healing with minimal complications. Traumatic, iatrogenic, and chronic wounds each require specific strategies, with wound closure, suture technique, and appropriate wound dressings significantly influencing success. Difficult wounds, such as those following bite injuries or complex postoperative defects, benefit from an interdisciplinary, individualized approach. This case report of a pharyngocutaneous fistula illustrates that conventional surgical procedures are not always sufficient. In addition, combined endo- and external NPWT can be a helpful option under certain conditions to promote granulation formation and support wound closure, although it is not yet standard practice. Future developments will be characterized by digital documentation, standardized follow-up, bioactive wound dressings, and regenerative procedures. The goal remains to shorten healing times, reduce complications, and optimize function and cosmetic outcomes. Overall, the article underscores the importance of an interdisciplinary and individualized approach that combines proven methods with innovative techniques to meet the complex requirements of complex wound care in the head and neck region.
C1 [Ganzle, Maximilian] Univ Klinikum Leipzig, Viszeral Transplant Thorax & Gefasschirurg, Leipzig, Germany.
   [Dietz, Andreas] Univ Klinikums Leipzig, HNO Klin, Leipzig, Germany.
C3 Leipzig University; Leipzig University
RP Gänzle, M (通讯作者)，Univ Klinikum Leipzig, Klin & Poliklin Hals Nasen & Ohrenheilkunde Plast, Liebigstr 12, D-04103 Leipzig, Germany.
EM Maximilian.Gaenzle@Medizin.Uni-Leipzig.de
OI Stoehr, Matthaeus/0000-0003-4219-4459
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0935-8943
EI 1438-8685
J9 LARYNGO RHINO OTOL
JI Laryngo-Rhino-Otol.
PD FEB
PY 2026
VL 105
IS 02
BP 113
EP 124
DI 10.1055/a-2623-3040
PG 12
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA DH6YZ
UT WOS:001683673700005
PM 41643652
DA 2026-07-24
ER

PT J
AU Collins, RA
   Dang, M
   McReynolds, S
   Puckett, Y
   Ronaghan, CA
AF Collins, Reagan A.
   Dang, Michael
   McReynolds, Shirley
   Puckett, Yana
   Ronaghan, Catherine A.
TI Use of a dynamic tissue system and biological xenograft in complex
   traumatic wound closure
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dynamic tissue system; flap reconstruction; muscle biomechanics; plastic
   surgery; porcine urinary bladder matrix; traumatic injury; xenograft;
   wound; wound care; wound dressing; wound healing
ID INFECTION
AB Objective: Asymmetrical dimensions and nonlinear margins of a multilayered traumatic wound often preclude healing via primary intention. We present the case of an otherwise healthy 21-year-old male who sustained trauma following a boating accident.
   Method: The patient sustained three lacerations to the posterior thighs from the boat propeller. The most extensive wound measured 25x10x6cm of muscle extrusion with a divot fracture involving the posterior femur.
   Results: Primary closure and restoration of muscle biomechanics was achieved using a combination of a dynamic tissue system (DTS) and porcine urinary bladder matrix (PUBM) xenograft. After 24 days of treatment in hospital, the patient was discharged without the need for home health, outpatient wound care, or ongoing negative pressure wound therapy. The patient recovered full function of the legs and was cleared for participation in all activities.
   Conclusion: This complex traumatic boat propeller injury presented many challenges, including a transverse orientation on the extremity, degree of muscle injury/extrusion, and significant soft tissue loss. The combined application of a DTS with PUBM biological xenograft achieved a primary myocutaneous closure without the need for skin graft or flap reconstruction by plastic surgery.
C1 [Collins, Reagan A.; Dang, Michael] Texas Tech Univ Hlth Sci Ctr, Sch Med, Lubbock, TX 79430 USA.
   [McReynolds, Shirley; Ronaghan, Catherine A.] Texas Tech Univ Hlth Sci Ctr, Dept Surg, Lubbock, TX USA.
   [Puckett, Yana] West Virginia Univ, Dept Surg, Sch Med, Charleston, WV USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center; Texas Tech University System; Texas Tech University Health
   Sciences Center
RP Collins, RA (通讯作者)，Texas Tech Univ Hlth Sci Ctr, Sch Med, Lubbock, TX 79430 USA.
EM reagan.collins@ttuhsc.edu
RI /ABG-8917-2020
CR Boyce DE, 2006, BMJ-BRIT MED J, V332, P710, DOI 10.1136/bmj.332.7543.710
   Chen C, 2019, TISSUE ENG PT A, V25, P257, DOI [10.1089/ten.tea.2018.0080, 10.1089/ten.TEA.2018.0080]
   Kimmel Howard, 2010, J Am Col Certif Wound Spec, V2, P55, DOI 10.1016/j.jcws.2010.11.002
   Medberry CJ, 2012, J SURG RES, V173, P38, DOI 10.1016/j.jss.2010.08.035
   Oliva Francesco, 2013, Muscles Ligaments Tendons J, V3, P313, DOI 10.32098/mltj.04.2013.12
   Reimer MW, 2008, CAN J SURG, V51, P209
   Ribeiro NFF, 2010, BURNS, V36, P9, DOI 10.1016/j.burns.2009.03.002
   Singh N, 2008, AM SURGEON, V74, P217
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   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 11
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2023
VL 32
SU 9
BP S12
EP S15
DI 10.12968/jowc.2023.32.Sup9.S12
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA R9JR1
UT WOS:001067447000010
PM 37682802
DA 2026-07-24
ER

PT J
AU Älgå, A
   Malmstedt, J
   Fagerdahl, AM
AF Alga, Andreas
   Malmstedt, Jonas
   Fagerdahl, Ann-Mari
TI Wound specific quality of life after blast or gunshot injury: Validation
   of the wound QoL instrument
SO PLOS ONE
LA English
DT Article
ID TRANSLATION; MORTALITY; THERAPY; DISEASE
AB Background
   Acute blast or gunshot wounds have a negative effect on the patients' health related quality of life (HRQoL). No validated instrument exists to assess the HRQoL of patients with such wounds. Therefore, we aimed to test and validate a subscale of an existing HRQoL instrument among patients with acute blast or gunshot wounds.
   Methods
   We used data from a randomized controlled trial comparing negative pressure wound therapy with standard treatment of civilian adults with acute extremity blast or gunshot wounds. We evaluated the reliability (internal consistency, stability) and validity of the body subscale of the Wound QoL instrument using the World Health Organisation 20 question self-reporting questionnaire as gold standard.
   Results
   A total of 152 participants were included in the study. The participants were predominantly (93.4%) male, and median age was 29.0 years (IQR 21.0-34.0). The internal consistency was acceptable while a test-retest analysis indicated instability in the Wound QoL instrument. The content validity of the instrument was considered satisfactory; however, the criterion validity was found to be insufficient.
   Conclusions
   Our results indicate that Wound QoL is a promising instrument for the assessment of wound specific HRQoL among patients with acute blast or gunshot wounds. Further testing and validation is needed.
C1 [Alga, Andreas; Malmstedt, Jonas; Fagerdahl, Ann-Mari] Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
   [Alga, Andreas] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
C3 Sodersjukhuset Hospital; Karolinska Institutet; Karolinska Institutet
RP Älgå, A (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.; Älgå, A (通讯作者)，Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
EM andreas.alga@ki.se
RI Älgå, Andreas/B-1070-2019
OI Älgå, Andreas/0000-0001-5245-7668
FU Swedish National Board of Health and Welfare; Stockholm County Council
   (ALF grant)
FX AA received funding from the Swedish National Board of Health and
   Welfare, and the Stockholm County Council (ALF grant). The funders did
   not play any role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 29
TC 2
Z9 4
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 31
PY 2022
VL 17
IS 10
AR e0277094
DI 10.1371/journal.pone.0277094
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O6MF8
UT WOS:001044919700056
PM 36315560
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hutchinson, LE
   Franke, JD
   Mailey, BA
AF Hutchinson, Lauren E.
   Franke, Jacob D.
   Mailey, Brian A.
TI Necrotizing fasciitis secondary to lake water inoculation with
   Aeromonas sobria A case report
SO MEDICINE
LA English
DT Article
DE Aeromonas sobria; lake water infection; necrotizing fasciitis
ID MANAGEMENT
AB Rationale: Necrotizing fasciitis (NF) is a rapidly progressing bacterial soft tissue infection with a high mortality rate. It is characterized by significant soft tissue destruction with associated sepsis. The mainstay of treatment is coverage with appropriate broad-spectrum antibiotic therapy and emergent surgical debridement. Patient concerns: A previously healthy 66-year-old female presented with a deep laceration to her right, posterior calf with subsequent contamination with lake water. After the wound was irrigated and closed, the patient developed NF. Diagnosis: Laceration of the right lower extremity complicated by NF secondary to Aeromonas sobria. Interventions: The patient underwent emergent surgical debridements with intravenous broad-spectrum antibiotics and negative pressure wound therapy. The lower extremity was reconstructed with split-thickness skin grafts. Outcomes: The patient's initial penetrating trauma was closed in the emergency room, and the patient was discharged home with antibiotics. She returned the next day with unstable vitals and was admitted to the intensive care unit. Her condition continued to deteriorate, and she underwent serial surgical debridements. Her condition improved and was discharged home after 13 days in the hospital. Lessons Learned: Close monitoring for NF is important for tissue infections sustained in aquatic environments. Timely identification and surgical management of NF increases overall survival.
C1 [Hutchinson, Lauren E.; Mailey, Brian A.] Southern Illinois Univ, Inst Plast Surg, Sch Med, POB 19653, Springfield, IL 62794 USA.
   [Franke, Jacob D.] Southern Illinois Univ, Sch Med, Springfield, IL 62794 USA.
C3 Southern Illinois University System; Southern Illinois University;
   Southern Illinois University System; Southern Illinois University
RP Mailey, BA (通讯作者)，Southern Illinois Univ, Inst Plast Surg, Sch Med, POB 19653, Springfield, IL 62794 USA.
EM bmailey48@siumed.edu
RI ; /AAJ-7965-2021; Franke, Jacob/LSJ-8887-2024
OI Mailey, Brian/0000-0002-2846-7556; 
CR Bhatia N, 2017, CASE REP MED, V2017, DOI 10.1155/2017/4607582
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NR 16
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR 12
PY 2021
VL 100
IS 10
AR e24981
DI 10.1097/MD.0000000000024981
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SO5TN
UT WOS:000659034600062
PM 33725868
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Stenqvist, CP
   Nielsen, CT
   Napolitano, GM
   Larsen, BM
   Flies, MJ
   Brander, DC
   Lynge, E
   Pallesen, P
AF Stenqvist, Charlotte P.
   Nielsen, Camilla T.
   Napolitano, George M.
   Larsen, Bo M.
   Flies, Mitchell J.
   Brander, Ditte C.
   Lynge, Elsebeth
   Pallesen, Per
TI Does closed incision negative wound pressure therapy in non-traumatic
   major lower-extremity amputations improve survival rates?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE amputation; diabetes; infection
ID LOWER-LIMB AMPUTATION; GENERAL-ANESTHESIA; MORTALITY; RISK
AB Closed incision negative pressure wound therapy (CINPWT) has been shown to be clinically effective compared with the traditional gauze dressing, reducing surgical site infections and wound complications. We evaluated the effect of CINPWT compared with gauze dressing on the need for revision surgery and survival after non-traumatic major lower amputation. We included 309 patients undergoing 403 major lower amputations in a retrospective study from January 1, 2010 to November 23, 2017. A total of 139 patients received CINPWT, and 170 patients received stump bandage. There was no statistically significant difference between the two groups regarding the need for revision surgery (P = .45). Fourteen stump bandage patients and 15 CINPWT patients died in hospital (P = .57). One year after amputation, 55 CINPWT patients and 66 stump bandage patients had died (P = .82). Survival probabilities adjusted for age and gender 2 years after amputation were .52 (.43-.61) and .49 (.42-.58), respectively, and 3 years after amputation were .36 (.25-.50) and .39 (.32-.47), respectively. We also found no significant difference in the need for revision surgery in survival probabilities up till 3 years after amputation between patients treated with CINPWT and patients treated with gauze bandage postoperatively.
C1 [Stenqvist, Charlotte P.; Nielsen, Camilla T.; Larsen, Bo M.; Flies, Mitchell J.; Brander, Ditte C.; Pallesen, Per] Nykoebing Falster Hosp, Dept Orthoped Surg, Nykoebing Falster, Denmark.
   [Napolitano, George M.] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Lynge, Elsebeth] Univ Copenhagen, Nykoebing Falster Hosp, Ctr Epidemiol Res, Nykoebing Falster, Denmark.
C3 University of Copenhagen; University of Copenhagen
RP Stenqvist, CP (通讯作者)，Bentsensvej 12 A, DK-4330 Hvalso, Denmark.
EM charlotte_stenqvist@hotmail.com
OI Toft Nielsen, Camilla/0000-0003-1444-8730
CR Chery J, 2014, ANN VASC SURG, V28, P1149, DOI 10.1016/j.avsg.2013.07.033
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NR 17
TC 7
Z9 7
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2019
VL 16
IS 5
BP 1171
EP 1177
DI 10.1111/iwj.13176
EA AUG 2019
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JG7RQ
UT WOS:000480641300001
PM 31407512
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Chary, PS
   Urati, A
   Shaikh, S
   Yadav, R
   Bhavana, V
   Rajana, N
   Mehra, NK
AF Chary, Padakanti Sandeep
   Urati, Anuradha
   Shaikh, Samia
   Yadav, Rati
   Bhavana, Valmala
   Rajana, Naveen
   Mehra, Neelesh Kumar
TI Nanotechnology-enabled approaches for combating diabetic foot ulcer
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Diabetic; Wound; Cryogel; Nanotechnology; Pathophysiology
ID HYPERBARIC-OXYGEN THERAPY; DRUG-DELIVERY; LOWER-LIMB; MANAGEMENT;
   STANDARD; PATHOPHYSIOLOGY; DIFFERENTIATION; NANOPARTICLES;
   NANOMATERIALS; BIOMATERIALS
AB Diabetic Foot Ulcer (DFU) remains a critical and increasingly prevalent complication of Diabetes Mellitus, affecting nearly 25 % of individuals with diabetes and contributing significantly to global healthcare burdens. Existing therapeutic modalities often fail to address the chronic and multifaceted nature of DFU, leaving many patients at risk of severe outcomes, including limb loss and reduced quality of life. This urgency is compounded by the growing diabetes epidemic, highlighting the pressing need for innovative and effective interventions. Nanoformulations, including silver nanoparticles and nanofibers, have emerged as effective tools for diabetic foot ulcer (DFU) management, offering targeted drug delivery and enhanced wound healing. Early in vivo studies indicate significant potential for nanoformulations to transform the DFU therapeutic landscape. Complementary advanced techniques, such as Negative Pressure Wound Therapy (NPWT), Hyperbaric Oxygen Therapy, Bioengineered Skin Substitutes, and Stem Cell Therapy, further enrich the treatment arsenal. Despite these advancements, regulatory hurdles remain a critical challenge to the broader adoption of nanoformulations. This review provides a comprehensive analysis of nanotechnology-enabled methodologies in DFU management, underscoring their potential to address unmet clinical needs and the urgency for their integration into contemporary practice amidst the escalating diabetes burden.
C1 [Chary, Padakanti Sandeep; Shaikh, Samia; Yadav, Rati; Bhavana, Valmala; Rajana, Naveen; Mehra, Neelesh Kumar] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Pharmaceut Nanotechnol Res Lab, Hyderabad, Telangana, India.
   [Urati, Anuradha] Natl Inst Pharmaceut Educ & Res, Dept Biol Sci, Hyderabad, Telangana, India.
C3 National Institute of Pharmaceutical Education & Research, Hyderabad;
   National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali); National Institute of Pharmaceutical Education & Research,
   S.A.S. Nagar (Mohali); National Institute of Pharmaceutical Education &
   Research, Hyderabad
RP Mehra, NK (通讯作者)，Natl Inst Pharmaceut Educ & Res NIPER, Minist Chem & Family Welf, Dept Pharmaceut, Pharmaceut Nanotechnol Res Lab, Hyderabad 500037, Telangana, India.
EM neelesh@niperhyd.ac.in
RI Mehra, Neelesh/AAJ-5201-2021
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NR 167
TC 3
Z9 3
U1 3
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD MAR
PY 2025
VL 105
AR 106593
DI 10.1016/j.jddst.2024.106593
EA JAN 2025
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA T9B7M
UT WOS:001407878900001
DA 2026-07-24
ER

PT J
AU Moffatt, CJ
   Murray, S
   Aubeeluck, A
   Quere, I
AF Moffatt, Christine J.
   Murray, Susie
   Aubeeluck, Aimee
   Quere, Isabelle
TI Communication with patients using negative wound pressure therapy and
   their adherence to treatment
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE adherence; communication; concordance; medical devices; negative
   pressure wound therapy
ID COMPRESSION THERAPY; LEG ULCERS; PART 2; IMPACT; RECURRENCE; EXPERIENCE;
   EDUCATION; BARRIERS; OUTCOMES; PEOPLE
AB Objective: The purpose of this study was to explore the challenges of communication between patients and health professionals, and patient adherence to treatment for hard-to-heal wounds when using negative wound pressure therapy (NPWT).
   Methods: Face-to-face, semi-structured interviews were conducted with patients undergoing NPWT. Specific features of the NPWT device were the priority for discussion although other factors central to communication and adherence were also explored.
   Results: A total of 24 patients took part in the study. Data saturation was achieved during the analysis. Patients required ongoing support to understand complex and often protracted treatment and this was particularly important when specialist technology was used. A distinction was highlighted between those who decided not to adhere with therapy and those who did so unintentionally. Participants faced difficulties in their communications with health professionals and in ensuring their needs were listened to and addressed.
   Conclusion: Further research is needed to achieve a better understanding of this distinction and to evaluate interventions which can sustain adherence behaviours. Further exploration of how to establish concordant patient/health professional communications is warranted.
C1 [Moffatt, Christine J.] Nottingham Trent Univ, Nottingham, England.
   [Moffatt, Christine J.; Quere, Isabelle] Univ Montpellier I, CHU Eloi, EA2992, Montpellier Med Vasc, Montpellier, France.
   [Murray, Susie] CRICP, London, England.
   [Aubeeluck, Aimee] Univ Nottingham, Nottingham, England.
C3 Nottingham Trent University; Universite de Montpellier; CHU de
   Montpellier; University of Nottingham
RP Moffatt, CJ (通讯作者)，Nottingham Trent Univ, Nottingham, England.; Moffatt, CJ (通讯作者)，Univ Montpellier I, CHU Eloi, EA2992, Montpellier Med Vasc, Montpellier, France.
EM Christine.Moffatt@ntu.ac.uk
RI ; Quere, Isabelle/AAB-8519-2020; aubeeluck, aimee/B-9782-2008
OI Moffatt, Christine/0000-0002-2436-0129; Quere,
   Isabelle/0000-0002-1492-9764; aubeeluck, aimee/0000-0003-3388-049X
FU Smith&Nephew Healthcare
FX The work was supported by a research grant from Smith&Nephew Healthcare.
   Smith&Nephew were not involved in the analysis or writing of this paper.
   There are no conflicts of interest to declare.
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NR 55
TC 6
Z9 7
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2019
VL 28
IS 11
BP 738
EP 756
DI 10.12968/jowc.2019.28.11.738
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA JM9YA
UT WOS:000496560300006
PM 31721670
DA 2026-07-24
ER

PT J
AU He, R
   Qi, X
   Wen, B
   Li, XY
   Guo, L
AF He, Rui
   Qi, Xin
   Wen, Bing
   Li, XiangYan
   Guo, Li
TI Successful treatment of a rare extended retroperitoneal necrotizing soft
   tissue infection caused by extended-spectrum beta-lactamase-producing
   Escherichia coli A case report
SO MEDICINE
LA English
DT Article
DE ESBL-producing Escherichia coli; necrotizing soft tissue infection;
   retroperitoneal
ID FASCIITIS; MANAGEMENT; DIAGNOSIS; MORTALITY
AB Rationale: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli).
   Patient concerns: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day.
   Diagnoses: He was admitted with an initial diagnosis of cellulitis.
   Interventions: Debridement was performed after the scrotum developed necrosis on day 2 of hospitalization. The source of infection was found to be an idiopathic retroperitoneal abscess, which was confirmed by computed tomography. Two consecutive microbiological cultures (aerobic plus anaerobic) of the tissue revealed the presence of ESBL-producing E coli. With the application of negative pressure wound therapy (NPWT), we sutured the wound after consecutive debridement.
   Outcomes: During the 32 months of follow-up, the patient recovered very well and felt extremely satisfied.
   Lessons: This case reminds us that ESBL-producing E coli can cause retroperitoneal abscesses, which may induce NSTI. Aggressive debridement and broad-spectrum antibiotics should be administrated immediately when NSTI is suspected, and NPWT is an effective adjuvant therapy for wound closure.
C1 [He, Rui; Qi, Xin; Wen, Bing] Peking Univ, Hosp 1, Dept Plast Surg & Burn, Beijing, Peoples R China.
   [Li, XiangYan] Peking Univ, Hosp 1, Dept Antiinfect, Beijing, Peoples R China.
   [Guo, Li] Peking Univ, Hosp 1, Dept Radiol, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University
RP Qi, X (通讯作者)，Peking Univ, Hosp 1, Dept Plast Surg & Burn, Beijing, Peoples R China.
EM 04983@pkufh.cn
RI Qi, Xin/O-5922-2019; Li, Xiangyan/JDW-4460-2023
OI Qi, Xin/0000-0003-1124-2374; Li, Xiangyan/0000-0001-6780-6314
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NR 20
TC 7
Z9 7
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2016
VL 95
IS 49
AR e5576
DI 10.1097/MD.0000000000005576
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EF0TW
UT WOS:000390040000067
PM 27930570
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Giordano, P
   Schembari, E
   Keshishian, K
   Leo, CA
AF Giordano, P.
   Schembari, E.
   Keshishian, K.
   Leo, C. A.
TI Negative pressure-assisted endoscopic pilonidal sinus treatment
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Pilonidal sinus; Pilonidal disease; EPSiT; NPWT; Minimally invasive
   treatment
AB Background Endoscopic pilonidal sinus treatment (EPSiT) is a novel minimally invasive option for the treatment of pilonidal sinus disease (PSD). To optimise the postoperative wound management after EPSiT, an ultraportable negative pressure wound therapy (NPWT) device was used. The aim of this study was to assess the clinical outcomes of negative pressure-assisted (NPA) EPSiT. Methods All patients with PSD treated by EPSIT from November 2017 to October 2019 were managed postoperatively with a commercially available NPTW dressing applied to the wound. All patients were prospectively entered into a dedicated database. Primary outcome measures were healing rate and return to normal activities. Secondary outcomes were postoperative complications and patient satisfaction. Results Thirteen male patients underwent NPA EPSiT (mean age 27.8 years, range 16-52 years). Two patients had previous surgery for PSD. The mean follow-up was 14 months (range 4-28 months). In two patients, only partial healing of the tract was achieved. One of these required a further successful NPA EPSiT, while the other one refused any other treatment because of the lack of symptoms. Eight patients were very satisfied and 5 were satisfied with this treatment. Conclusions NPA EPSiT is a simple method for improving postoperative wound management, facilitating a quicker recovery and possibly improving overall patient satisfaction.
C1 [Giordano, P.; Schembari, E.; Keshishian, K.; Leo, C. A.] Royal London Hosp, Dept Colorectal Surg, Whitechapel Rd, London E1 1RR, England.
   [Leo, C. A.] Imperial Coll London, Dept Canc & Surg, London, England.
C3 Barts Health NHS Trust; Royal London Hospital; Imperial College London
RP Giordano, P (通讯作者)，Royal London Hosp, Dept Colorectal Surg, Whitechapel Rd, London E1 1RR, England.
EM p.giordano@londoncolorectal.org
RI Schembari, Elena/NEU-2962-2025; Leo, Cosimo Alex/AAJ-9433-2020
OI Leo, Cosimo Alex/0000-0001-5759-0345; Giordano,
   Pasquale/0000-0002-3603-4574
CR Atkins BZ, 2011, INT WOUND J, V8, P56, DOI 10.1111/j.1742-481X.2010.00743.x
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NR 22
TC 11
Z9 13
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUN
PY 2021
VL 25
IS 6
BP 739
EP 743
DI 10.1007/s10151-021-02431-w
EA MAR 2021
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA SC8OA
UT WOS:000631754200002
PM 33755853
DA 2026-07-24
ER

PT J
AU Lo Torto, F
   Monfrecola, A
   Kaciulyte, J
   Ciudad, P
   Casella, D
   Ribuffo, D
   Carlesimo, B
AF Lo Torto, Federico
   Monfrecola, Ambra
   Kaciulyte, Juste
   Ciudad, Pedro
   Casella, Donato
   Ribuffo, Diego
   Carlesimo, Bruno
TI Preliminary result with incisional negative pressure wound therapy and
   pectoralis major muscle flap for median sternotomy wound infection in a
   high-risk patient population
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Deep sternal wound infection; Pectoralis major muscle flap; Prevena
ID MYOCUTANEOUS ADVANCEMENT FLAPS; SURGICAL INCISIONS; MANAGEMENT-SYSTEM;
   CARDIAC-SURGERY; COMPLICATIONS; MORTALITY; MEDIASTINITIS; CLOSURE; COST
AB Deep sternal wound infection (DSWI) represents a dangerous complication that can follow open-heart surgery with median sternotomy access. Muscle flaps, such as monolateral pectoralis major muscle flap (MPMF), represent the main choices for sternal wound coverage and infection control. Negative pressure incision management system has proven to be able to reduce the incidence of these wounds' complications. Prevena represents one of these incision management systems and we aimed to evaluate its benefits. A total of 78 patients with major risk factors that presented post-sternotomy DSWI following cardiac surgery was selected. Thrity patients were treated with MPMF and Prevena (study group). Control group consisted of 48 patients treated with MPMF and conventional wound dressings. During the follow-up period, 4 (13%) adverse events occurred in the study group, whereas 18 complications occurred (375%) in the control group. Surgical revision necessity and mean postoperative time spent in the intensive care unit were both higher in the control group. Our results evidenced Prevena system's ability in improving the outcome of DSWI surgical treatment with MPMF in a high-risk patient population.
C1 [Lo Torto, Federico; Monfrecola, Ambra; Kaciulyte, Juste; Casella, Donato; Ribuffo, Diego; Carlesimo, Bruno] Sapienza Univ Rome, Dept Surg P Valdoni, Unit Plast & Reconstruct Surg, Rome, Italy.
   [Ciudad, Pedro] China Med Univ Hosp, Dept Plast Surg, Taichung, Taiwan.
C3 Sapienza University Rome; China Medical University Taiwan; China Medical
   University Hospital - Taiwan
RP Kaciulyte, J (通讯作者)，Sapienza Univ Rome, Unit Plast & Reconstruct Surg, Dept Surg P Valdoni, Viale Unita Italia 6, I-02032 Fara In Sabina, RI, Italy.
EM justekc@gmail.com
RI Torto, Federico/AAY-1852-2021; RIBUFFO, Diego/HLG-3305-2023
OI RIBUFFO, Diego/0000-0002-1844-7850
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NR 32
TC 23
Z9 23
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 1335
EP 1339
DI 10.1111/iwj.12808
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400059
PM 28901717
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Coccolini, F
   Improta, M
   Cicuttin, E
   Catena, F
   Sartelli, M
   Bova, R
   de' Angelis, N
   Gitto, S
   Tartaglia, D
   Cremonini, C
   Ordonez, C
   Baiocchi, GL
   Chiarugi, M
AF Coccolini, Federico
   Improta, Mario
   Cicuttin, Enrico
   Catena, Fausto
   Sartelli, Massimo
   Bova, Raffaele
   de' Angelis, Nicola
   Gitto, Stefano
   Tartaglia, Dario
   Cremonini, Camilla
   Ordonez, Carlos
   Baiocchi, Gian Luca
   Chiarugi, Massimo
TI Surgical site infection prevention and management in immunocompromised
   patients: a systematic review of the literature
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Infection; Immunity; Wound; Care; Costs; Drugs; Inflammatory
ID PRESSURE WOUND THERAPY; METASTATIC COLORECTAL-CANCER; LIVER-TRANSPLANT
   RECIPIENTS; RISK-FACTORS; KIDNEY-TRANSPLANT; IMMUNOSUPPRESSIVE THERAPY;
   ANTIBIOTIC-PROPHYLAXIS; RENAL-TRANSPLANTATION; HEALING COMPLICATIONS;
   SURGERY
AB Background Immunocompromised patients are at higher risk of surgical site infection and wound complications. However, optimal management in the perioperative period is not well established. Present systematic review aims to analyse existing strategies and interventions to prevent and manage surgical site infections and other wound complications in immunocompromised patients. Methods A systematic review of the literature was conducted. Results Literature review shows that partial skin closure is effective to reduce SSI in this population. There is not sufficient evidence to definitively suggest in favour of prophylactic negative pressure wound therapy. The use of mammalian target of rapamycin (mTOR) and calcineurin inhibitors (CNI) in transplanted patient needing ad emergent or undeferrable abdominal surgical procedure must be carefully and multidisciplinary evaluated. The role of antibiotic prophylaxis in transplanted patients needs to be assessed. Conclusion Strict adherence to SSI infection preventing bundles must be implemented worldwide especially in immunocompromised patients. Lastly, it is necessary to elaborate a more widely approved definition of immunocompromised state. Without such shared definition, it will be hard to elaborate the needed methodologically correct studies for this fragile population.
C1 [Coccolini, Federico; Cicuttin, Enrico; Tartaglia, Dario; Cremonini, Camilla; Chiarugi, Massimo] Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisa 1, I-56100 Pisa, Italy.
   [Improta, Mario; Bova, Raffaele] Bologna Univ Hosp, Gen Surg Dept, Bologna, Italy.
   [Catena, Fausto] Parma Univ Hosp, Emergency Surg Dept, Parma, Italy.
   [Sartelli, Massimo] Macerata Hosp, Gen Surg Dept, Macerata, Italy.
   [de' Angelis, Nicola] Henri Mondor Hosp, Unit Digest & Hepatobiliary Pancreat Surg, Creteil, France.
   [de' Angelis, Nicola] Univ Paris Est, UPEC, Creteil, France.
   [Gitto, Stefano] Firenze Univ, Dept Expt & Clin Med, Florence, Italy.
   [Ordonez, Carlos] Fdn Valle Lili, Dept Surg, Cali, Colombia.
   [Baiocchi, Gian Luca] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; IRCCS
   Azienda Ospedaliero-Universitaria di Bologna; University of Parma;
   University Hospital of Parma; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Fundacion Valle del Lili; University of Brescia
RP Coccolini, F (通讯作者)，Pisa Univ Hosp, Gen Emergency & Trauma Surg Dept, Via Paradisa 1, I-56100 Pisa, Italy.
EM Federico.coccolini@gmail.com
RI Tartaglia, Dario/AAJ-1735-2020; de'Angelis, Nicola/Q-7759-2016;
   Cicuttin, Enrico/GXG-6365-2022; Coccolini, Federico/AAJ-6507-2020;
   Chiarugi, Massimo/ABQ-7280-2022; Gitto, Stefano/J-9922-2018;
   /AAD-7440-2020
OI de'Angelis, Nicola/0000-0002-1211-4916; Cicuttin,
   Enrico/0000-0003-4584-9940; Coccolini, Federico/0000-0001-6364-4186;
   Chiarugi, Massimo/0000-0001-6905-2499; Gitto,
   Stefano/0000-0002-8042-6508; 
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NR 78
TC 41
Z9 50
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JUN 10
PY 2021
VL 16
IS 1
AR 33
DI 10.1186/s13017-021-00375-y
PG 13
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA SV4NH
UT WOS:000663797200003
PM 34112231
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lev-Tov, HA
   Hermak, S
AF Lev-Tov, Hadar Avihai
   Hermak, Sarah
TI Hydration response technology dressings for low to excessively exuding
   wounds: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE cellulose fibres; Cutimed Sorbion; exudate; gelling agent; hydration
   response technology; wound; wound care; wound dressing; wound healing
ID COST-EFFECTIVENESS; CARE; MANAGEMENT; SERIES; ULCERS
AB Objective: The aim of this systematic review was to identify and qualify the current available evidence of the wound exudate handling capabilities and the cost-effectiveness of hydration response technology (HRT). HRT combines physically modified cellulose fibres and gelling agents resulting in wound dressings that absorb and retain larger quantities of wound exudate. Method: A systematic search was conducted in MEDLINE (via PubMed and PubMed Central) according to the Preferred Reporting Items for Systematic Reviews and Meta -Analyses (PRISMA). The search was conducted using an unlimited search period. Studies or reviews that evaluated effect on wound exudate and cost-effectiveness, as well as the impact on wound healing were considered. Records focusing on wound management using HRT devices were included. Results: The literature search identified four studies and one comparative analysis, ranging from low to moderate quality, that compared HRT dressings to other interventions (carboxymethyl cellulose dressing, other superabsorbent dressings, negative pressure wound therapy). Conclusion: The analysed data supported the beneficial use of dressings with HRT for exuding wounds which was characterised by fewer dressing changes, improved periwound skin conditions and reduced costs.
C1 [Lev-Tov, Hadar Avihai; Hermak, Sarah] Univ Miami, Leonard M Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Miami
RP Lev-Tov, HA (通讯作者)，Univ Miami, Leonard M Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
EM hlevtov@med.miami.edu
CR Association of the Scientific Medical Societies in Germany, 2012, Local therapy of chronic wounds in patients with the risks of peripheral arterial occlusive disease, diabetes mellitus, chronic venous insufficiency
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NR 64
TC 0
Z9 1
U1 1
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2024
VL 33
IS 6
DI 10.12968/jowc.2024.0088
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XH8Z8
UT WOS:001260896600002
PM 38843010
DA 2026-07-24
ER

PT J
AU Gounden, V
   Singh, M
AF Gounden, Varshan
   Singh, Moganavelli
TI Hydrogels and Wound Healing: Current and Future Prospects
SO GELS
LA English
DT Review
DE chronic wounds; wound dressings; hydrogels; wound healing; polymers
ID DRUG-DELIVERY; DRESSINGS
AB The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. This review provides an updated discussion of the leading natural and synthetic hydrogels utilized in wound healing, details the latest advancements in hydrogel technology, and explores alternate approaches in this field. Search engines Scopus, PubMed, Science Direct, and Web of Science were utilized to review the advances in hydrogel applications over the last fifteen years.
C1 [Gounden, Varshan; Singh, Moganavelli] Univ KwaZulu Natal, Nanogene & Drug Delivery Lab, Discipline Biochem, Private Bag X54001, Durban, South Africa.
C3 University of Kwazulu Natal
RP Singh, M (通讯作者)，Univ KwaZulu Natal, Nanogene & Drug Delivery Lab, Discipline Biochem, Private Bag X54001, Durban, South Africa.
EM 219006317@stu.ukzn.ac.za; singhm1@ukzn.ac.za
RI Singh, Moganavelli/N-5100-2013
OI Singh, Moganavelli/0000-0002-9985-6567
FU National Research Foundation of South Africa
FX No Statement Available
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NR 106
TC 275
Z9 300
U1 45
U2 260
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2310-2861
J9 GELS-BASEL
JI Gels
PD JAN
PY 2024
VL 10
IS 1
AR 43
DI 10.3390/gels10010043
PG 21
WC Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Polymer Science
GA FW5R3
UT WOS:001148908400001
PM 38247766
OA Green Submitted, gold
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Thermann, F
   Wollert, U
AF Thermann, Florian
   Wollert, Ulrich
TI Continuous Irrigation as a Therapeutic Option for Graft Infections of
   the Groin
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; MUSCLE FLAP COVERAGE;
   VASCULAR GRAFT; MANAGEMENT; RISK; PRESERVATION
AB Wound infections following vascular procedures occur in 1-7 % of patients and can lead to severe problems including amputation and death. There are no established treatment options for this complication. The aim of our study was to introduce continuous irrigation as a new treatment technique.
   We retrospectively evaluated patients who had undergone bypass surgery involving the groin and had been treated with continuous irrigation because of deep wound infections. The irrigation solution was saline in all cases. The patients were additionally treated with antibiotics. The end point of the study was either complete wound healing or complications such as recurrent infection, amputation, or death.
   Wound complications occurred in 65 (15.3 %) of 424 operations. Overall, 20 patients (4.7 %) developed a deep wound infection involving prosthetic graft material. They were treated with continuous irrigation. Complete wound healing was achieved in 13 cases (65.0 %). One patient died. No amputations were necessary.
   Based on our results, constant irrigation may be a therapeutic option in patients with deep wound infections. The main advantages of continuous irrigation over other treatments are ongoing bacterial reduction despite primary wound closure and the ability to measure the remaining colonization by microbiologic examination of the irrigation fluid.
C1 [Thermann, Florian] Univ Teaching Hosp Carl von Basedow, Dept Vasc Surg, D-06217 Merseburg, Germany.
   [Wollert, Ulrich] Univ Teaching Hosp St Elisabeth, Dept Gen & Vasc Surg, D-06110 Halle, Germany.
C3 Martin Luther University Halle Wittenberg
RP Thermann, F (通讯作者)，Univ Teaching Hosp Carl von Basedow, Dept Vasc Surg, Weisse Mauer 52, D-06217 Merseburg, Germany.
EM f.thermann@klinikum-saalekreis.de
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NR 28
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD OCT
PY 2014
VL 38
IS 10
BP 2589
EP 2596
DI 10.1007/s00268-014-2650-8
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP6SY
UT WOS:000342209200017
PM 24879069
DA 2026-07-24
ER

PT J
AU Arslan, H
   Çinar, C
   Bingöl, UA
   Yücel, OA
AF Arslan, Hakan
   Cinar, Can
   Bingol, Ugur Anil
   Yucel, Osman Akin
TI Subacute and delayed period microsurgical management of traumatic
   extremity injuries in pediatric population
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FREE-TISSUE TRANSFER; OPEN TIBIAL FRACTURES;
   WOUND THERAPY; FLAP COVERAGE; RECONSTRUCTION; CHILDREN; DEFECTS;
   TRANSPLANTATION; SERIES
AB The purpose of the present report is to evaluate the outcome of subacute and delayed period microsurgical reconstructions of traumatic extremity defects of the pediatric patients. Eighteen free tissue transfers had been performed in 18 patients. Patients ranged in age from 5 to 17 years of age and had a median age of 12.05 years. The time between trauma and free flap transfer varied between 8 and 86 days (mean, 30.8 days). Hospital stay ranged from 8 to 90 days, with a mean stay of 38.7 days. Postoperative complications were seen in 8 of 18 patients (44.4%). Re-exploration for venous thrombosis was necessary in two patients, and total flap loss occurred in one case. The average follow-up time was 34 months. One could conclude from our report and the reference literature that the frequently quoted dogma of a definitive defect closure within 7 days may have lost much of its justification. The final results obtained after delayed definitive soft tissue reconstruction compare favorably with results previously reported in the literature from patient groups whose wounds could be closed in the early period within 7 days. (c) 2012 Wiley Periodicals, Inc. Microsurgery, 2012.
C1 [Arslan, Hakan] Istanbul Univ, Dept Plast Reconstruct & Aesthet Surg, Cerrahpasa Med Sch, TR-34098 Istanbul, Turkey.
   [Cinar, Can; Yucel, Osman Akin] Private Off, Istanbul, Turkey.
   [Bingol, Ugur Anil] Yeditepe Univ, Sch Med, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Yeditepe
   University
RP Arslan, H (通讯作者)，Istanbul Univ, Dept Plast Reconstruct & Aesthet Surg, Cerrahpasa Med Sch, TR-34098 Istanbul, Turkey.
EM hakanarsln@yahoo.com.tr
RI Arslan, Hakan/A-1770-2017; bingol, ugur anil/K-4989-2013
OI Arslan, Hakan/0000-0001-8838-8262; bingol, ugur anil/0000-0002-8098-5270
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NR 32
TC 14
Z9 15
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
J9 MICROSURG
JI Microsurgery
PD OCT
PY 2012
VL 32
IS 7
BP 527
EP 532
DI 10.1002/micr.22021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 019RR
UT WOS:000309757500004
PM 22821805
DA 2026-07-24
ER

PT J
AU Narayanan, AS
   Walley, KC
   Borenstein, T
   Luther, GA
   Jackson, JB
   Gonzalez, TA
AF Narayanan, Arvind S.
   Walley, Kempland C.
   Borenstein, Todd
   Luther, G. Aman
   Jackson, J. Benjamin
   Gonzalez, Tyler A.
TI Surgical Strategies: Necrotizing Fasciitis of the Foot and Ankle Treated
   With Dermal Regeneration Matrix for Limb Salvage
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE necrotizing fasciitis; limb salvage; amputation; fasciotomy; fasciectomy
   dermal matrix; diabetes; decision making
AB Although necrotizing fasciitis is a life-threatening entity that needs expeditious treatment, cases involving the lower extremity are less commonly encountered than in the upper extremity. Surgical intervention is often required and likely lead to amputation (below-knee or above-knee) vs debridement in the lower extremity.
   Coverage options in the foot and ankle after serial debridements can present many challenges for limb salvage. Patients are often left with large soft tissue defects requiring coverage with a subsequent increase in relative morbidity. Treatment options for coverage in these cases include negative-pressure wound therapy, split-thickness skin grafting, free flap coverage, or higher-level amputation. In the diabetic population, who present with a lower extremity necrotizing infection, limb salvage is often a challenge given the multiple comorbidities associated with these patients including peripheral vascular disease, immunocompromised state, and neuropathy. Optimal treatment strategies for these necrotizing infections in the foot and ankle remain uncertain.
   We offer a technique tip for utilization of a dermal regeneration matrix to allow coverage of large soft tissue defect with exposed tendon and/or bone without the need for free flap coverage or higher-level amputation, thus allowing for an additional limb salvage option.
C1 [Narayanan, Arvind S.; Luther, G. Aman] WakeMed Hlth & Hosp, Raleigh, NC USA.
   [Narayanan, Arvind S.] Univ N Carolina, Dept Orthopaed Surg, Chapel Hill, NC 27515 USA.
   [Walley, Kempland C.] Penn State Milton S Hershey Med Ctr, Penn State Hershey Bone & Joint Inst, Dept Orthopaed Surg, Hershey, PA USA.
   [Borenstein, Todd] Huntington Orthopaed Inst, Pasadena, CA USA.
   [Jackson, J. Benjamin; Gonzalez, Tyler A.] Univ South Carolina, Dept Orthopaed Surg, 400 Palmetto Hlth Pkwy, Columbia, SC 29208 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; University of South
   Carolina System; University of South Carolina Columbia
RP Gonzalez, TA (通讯作者)，Univ South Carolina, Dept Orthopaed Surg, 400 Palmetto Hlth Pkwy, Columbia, SC 29208 USA.
EM tyleragonzalezmed@gmail.com
OI Walley, Kempland/0000-0003-4488-0663; Gonzalez,
   Tyler/0000-0002-3210-8097
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NR 30
TC 2
Z9 5
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JAN
PY 2021
VL 42
IS 1
BP 107
EP 114
DI 10.1177/1071100720952087
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA PR4GD
UT WOS:000607195000016
PM 32975443
DA 2026-07-24
ER

PT J
AU Boulton, AJM
   Viswanathan, V
AF Boulton, Andrew James Michael
   Viswanathan, V.
TI Evidence-based management of diabetic foot problems
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Diabetic foot; Prevention; Evidence-based therapy; Oxygen-based
   therapies; Foot Infections
ID PRESSURE WOUND THERAPY; ULCERS; MULTICENTER; OSTEOMYELITIS; PREVENTION;
   AMPUTATION; RISK; ANTIBIOTICS; ULCERATION; EDUCATION
AB At present we are experiencing a rapid rise in the global prevalence of diabetes and unfortunately, this is associated with an increase in many of the late complications of diabetes, particularly diabetic foot ulcers which have a significant impairment on quality of life as well as being associated with increased morbidity and mortality. The potential for preventing first and recurrent foot ulcers is reviewed particularly related to recent developments in smart technology and remote monitoring of foot temperature and pressures under high-risk feet. Recent trials on both these areas are reviewed and show promise for the future. Pharmacological approaches to reduce the incidence of foot ulcers are then considered and the small section on the potential role of fibrates which certainly demands further investigation. With respect to treatment of complex foot ulcers, a number of recent evidence-based therapies are described including sucrose octasulfate dressings, negative pressure wound therapy and topical wound oxygen therapy. Lastly, appropriate care and management of infected DFUs is considered particularly focusing on the area of osteomyelitis. A number of excellent recent Guidelines and related reviews are then listed to help readers further understand this rapidly developing and complex area.
C1 [Boulton, Andrew James Michael] Univ Manchester, Manchester, England.
   [Boulton, Andrew James Michael] Manchester Royal Infirm, Manchester, England.
   [Viswanathan, V.] MV Hosp Diabetes, Chennai, India.
C3 University of Manchester; University of Manchester
RP Boulton, AJM (通讯作者)，Manchester Royal Infirm, Diabet Endocrinol & Metab Ctr, Peter Mt Bldg,Oxford Rd, Manchester M13 9WL, England.
EM andrew.j.boulton@manchester.ac.uk
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   Frykberg RG, 2017, DIABETES CARE, V40, P973, DOI 10.2337/dc16-2294
   Game FL, 2008, DIABETOLOGIA, V51, P962, DOI 10.1007/s00125-008-0976-1
   Game F, 2018, LANCET DIABETES ENDO, V6, P870, DOI 10.1016/S2213-8587(18)30240-7
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   Krishnan S, 2008, DIABETES CARE, V31, P99, DOI 10.2337/dc07-1178
   Lavery LA, 2007, DIABETES CARE, V30, P14, DOI 10.2337/dc06-1600
   Li HK, 2019, NEW ENGL J MED, V380, P425, DOI 10.1056/NEJMoa1710926
   Lincoln NB, 2008, DIABETOLOGIA, V51, P1954, DOI 10.1007/s00125-008-1110-0
   Löndahl M, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3233
   Löndahl M, 2010, DIABETES CARE, V33, P998, DOI 10.2337/dc09-1754
   Lázaro-Martínez JL, 2014, DIABETES CARE, V37, P789, DOI 10.2337/dc13-1526
   Marinho LL, 2024, J AM COLL CARDIOL, V84, P408, DOI 10.1016/j.jacc.2024.05.028
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   Tone A, 2015, DIABETES CARE, V38, P302, DOI 10.2337/dc14-1514
   Yellin JI, 2022, ADV WOUND CARE, V11, P657, DOI 10.1089/wound.2021.0118
   Young MJ, 2008, DIABETES CARE, V31, P2143, DOI 10.2337/dc08-1242
NR 42
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV
PY 2025
VL 229
AR 112932
DI 10.1016/j.diabres.2025.112932
EA OCT 2025
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9DS8G
UT WOS:001603911900001
PM 41057113
DA 2026-07-24
ER

PT J
AU Semenic, D
   Abersek, N
   Zore, A
   Laganà, AS
   Lukanovic, D
AF Semenic, D.
   Abersek, N.
   Zore, A.
   Lagana, A. S.
   Lukanovic, D.
TI The challenge of complex wound healing caused by necrotizing fasciitis
   after infection of tension-free vaginal transobturator tape (TVT-O)
   incontinence material
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Necrotizing fasciitis; TVT and TVT-O complications
ID CONTINENCE SOCIETY; TERMINOLOGY; MANAGEMENT
AB Pelvic organ prolapse with or without stress urinary incontinence (SUI) is a common gynecological condition that occurs predominantly in middle and old age. Tension-free vaginal tape (TVT) technique is a surgical procedure for treatment of female SUI that is used worldwide. Severe complications are extremely rare. The authors present treatment methods with which they have successfully used for such cases. The Ljubljana University Medical Center carried out 2,587 TVT operations for genuine SUI between 1998 and 2017. The authors carried out a retrospective study to determine long-term success. However, in all of these years, they treated only two serious complications involving necrotizing fasciitis. Both patients were 61-years old, the first patient suffered necrotizing fasciitis shortly after her transobturator TVT (TVT-O) procedure, and the second six years after the initial surgery. Both of them had had repeated extensive fasciectomy, soft tissue debridement, and various modern wound dressing changes, and one of them had had negative pressure wound therapy. Severe complications of TVT-O are rare but present a possibility for great morbidity and mortality. Early surgical treatment plays an important role, together with additional medication.
C1 [Semenic, D.] Univ Med Ctr Ljubljana, Div Surg, Dept Surg Infect, Ljubljana, Slovenia.
   [Semenic, D.] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
   [Abersek, N.] Univ Med Ctr, Ljubljana, Slovenia.
   [Zore, A.; Lukanovic, D.] Univ Med Ctr Ljubljana, Div Gynaecol & Obstet, Dept Gynaecol, Ljubljana, Slovenia.
   [Lagana, A. S.] Univ Insubria, Filippo Ponte Hosp, Dept Obstet & Gynecol, Varese, Italy.
C3 University Medical Centre Ljubljana; University of Ljubljana; University
   Medical Centre Ljubljana; University Medical Centre Ljubljana;
   University of Insubria
RP Lukanovic, D (通讯作者)，Univ Med Ctr, Div Gynaecol & Obstet, Dept Gynaecol, Ljubljana, Slovenia.
EM david.lukanovic@gmail.com
RI Laganà, Antonio Simone/E-6466-2015; Lukanović, David/HOA-9601-2023
OI Laganà, Antonio Simone/0000-0003-1543-2802; 
CR Abrams P, 2003, UROLOGY, V61, P37, DOI 10.1016/S0090-4295(02)02243-4
   Bozkurt M, 2015, CLIN EXP OBSTET GYN, V42, P82
   Chennamsetty A, 2015, THER ADV UROL, V7, P203, DOI 10.1177/1756287215584740
   Corona PS, 2016, INJURY, V47, pS66, DOI 10.1016/S0020-1383(16)30609-X
   Haylen BT, 2010, NEUROUROL URODYNAM, V29, P4, DOI 10.1002/nau.20798
   Johnson DW, 2003, INT UROGYNECOL J, V14, P291, DOI 10.1007/s00192-003-1064-1
   Lukanovic A, 2003, ZDR VESTN, V72, P171
   Onwude J.L, 2009, BMJ CLIN EVID, V2009
   Orlowski HLP, 2016, ABDOM RADIOL, V41, P2294, DOI 10.1007/s00261-016-0749-0
   Singh A, 2016, ARCH ITAL UROL ANDRO, V88, P157, DOI 10.4081/aiua.2016.3.157
   van Stigt SFL, 2016, WORLD J EMERG SURG, V11, DOI 10.1186/s13017-016-0080-7
   Zhang ZB, 2016, INT UROGYNECOL J, V27, P103, DOI 10.1007/s00192-015-2798-2
NR 12
TC 1
Z9 1
U1 0
U2 1
PU IMR PRESS
PI SINGAPORE
PA #07-07, 151 CHIN SWEE ROAD, MANHATTAN HOUSE, SINGAPORE, SINGAPORE
SN 0390-6663
EI 2709-0094
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PY 2019
VL 46
IS 5
BP 844
EP 847
DI 10.12891/ceog4943.2019
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA JH4WD
UT WOS:000492770100039
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Schreiter, NA
   McCarthy, DP
   Fiedler, AG
   Young, N
   Demarais, D
   Anagnostopoulos, PV
   Hermsen, JL
AF Schreiter, Nicholas A.
   McCarthy, Daniel P.
   Fiedler, Amy G.
   Young, Natasha
   Demarais, Dean
   Anagnostopoulos, Petros V.
   Hermsen, Joshua L.
TI Helpful sternal wound vacuum-assisted closure techniques in two open
   chest situations: Central extracorporeal membrane oxygenation and
   sternal infection
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE deep sternal wound infection; ECMO; mediastinitis; sternum; wound vac
AB Background Dressing open sternal wounds after cardiac surgery can be challenging. In cases where extracorporeal membrane oxygenation (ECMO) is required, the sternum is left open with cannulae traversing the wound, making it difficult to create a water-tight seal and maintain sterility. Patients with a deep sternal infection may also be left with an open sternum between the time of debridement and reconstruction; in such cases, stabilizing the dressing in an ambulatory patient can pose a challenge. Methods Two cases are reviewed, each highlighting the solutions to the problems mentioned above. Results In case 1, a patient with an open sternum and central ECMO, we describe construction of a dressing that achieves air seal and blood seal, and helps maintain the cannulae in a safe, stable position. In case 2, an ambulatory patient, we describe a modification of a recently published "Two Bridge Technique" that provides a stable dressing in three dimensions. Conclusion Performance of specific techniques and attention to detail in complex situations can make a big difference in open sternum patients treated with temporary, vacuum-assisted dressings. Achieving vacuum and fluid seal is important for sterility, integrity of adjacent skin, and caregiver safety.
C1 [Schreiter, Nicholas A.; McCarthy, Daniel P.; Fiedler, Amy G.; Young, Natasha; Demarais, Dean; Anagnostopoulos, Petros V.; Hermsen, Joshua L.] Univ Wisconsin, Dept Surg, Div Cardiothorac Surg, Madison, WI 53593 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Hermsen, JL (通讯作者)，Univ Wisconsin, Dept Surg, Div Cardiothorac Surg, Clin Sci Ctr, 600 Highland Ave,H4-352, Madison, WI 53593 USA.
EM hermsen@surgery.wisc.edu
OI Schreiter, Nicholas/0000-0002-9002-7367
CR Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Waked K, 2018, INT WOUND J, V15, P198, DOI 10.1111/iwj.12823
NR 2
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2019
VL 34
IS 11
BP 1150
EP 1153
DI 10.1111/jocs.14209
EA AUG 2019
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JI1LP
UT WOS:000483233300001
PM 31441530
DA 2026-07-24
ER

PT J
AU Serraino, GF
   Dominijanni, A
   Jiritano, F
   Rossi, M
   Cuda, A
   Caroleo, S
   Brescia, A
   Renzulli, A
AF Serraino, Giuseppe F.
   Dominijanni, Andrea
   Jiritano, Federica
   Rossi, Michele
   Cuda, Aldo
   Caroleo, Santo
   Brescia, Adalgisa
   Renzulli, Attilio
TI Platelet-rich plasma inside the sternotomy wound reduces the incidence
   of sternal wound infections
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cardiac surgery; Platelet gel; Sternal wound infections
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS; CARDIAC-SURGERY; SITE
   INFECTION; GEL; COMPLICATIONS
AB Despite the large choice of wide-spectrum antibiotic therapy, deep sternal wound infection (DSWI) following cardiac surgery is a life-threatening complication worldwide. This study evaluated that the use of platelet-rich plasma (PRP) applied inside the sternotomy wound would reduce the effect of sternal wound infections, both superficial and deep. Between January 2007 and January 2012, 1093 consecutive patients underwent cardiac surgery through median sternotomy. Patients were divided into two groups. Group B, the study group, included those who received the PRP applied inside the sternotomy wound before closure. Group A, the control group, included patients who received a median sternotomy but without the application of PRP. Antibiotic prophylaxis remained unchanged across the study and between the two groups. Occurrence of DSWI was significantly higher in group A than in group B [10 of 671 (15%) versus 1 of 422 (020%), P = 0043]. Also, superficial sternal wound infections (SSWIs) were significantly higher in group A than in group B [19 of 671 (28%) versus 2 of 422 (05%), P = 0006]. The use of PRP can significantly reduce the occurrence of DSWI and SSWI in cardiac surgery.
C1 [Serraino, Giuseppe F.; Jiritano, Federica; Rossi, Michele; Cuda, Aldo; Renzulli, Attilio] Magna Graecia Univ Catanzaro, Cardiac Surg Unit, I-88100 Catanzaro, Italy.
   [Dominijanni, Andrea; Brescia, Adalgisa] Pugliese Ciaccio Hosp, Immunohaematol & Transfus Med Unit, Catanzaro, Italy.
   [Caroleo, Santo] Magna Graecia Univ Catanzaro, Anaesthesiol & Intens Care Unit, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro
RP Jiritano, F (通讯作者)，Magna Graecia Univ Catanzaro, Cardiac Surg Unit, I-88100 Catanzaro, Italy.
EM fede.j@hotmail.it
RI /ABH-8044-2020; Jiritano, Federica/ISU-5273-2023
OI Jiritano, Federica/0000-0002-6889-5686; SERRAINO, GIUSEPPE
   FILIBERTO/0000-0002-4804-9570
CR Almdahl SM, 2011, EUR J CARDIO-THORAC, V39, P44, DOI 10.1016/j.ejcts.2010.06.007
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NR 24
TC 28
Z9 32
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2015
VL 12
IS 3
BP 260
EP 264
DI 10.1111/iwj.12087
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CI1CA
UT WOS:000354476800007
PM 23692143
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Daeschlein, G
AF Daeschlein, Georg
TI Antimicrobial and antiseptic strategies in wound management
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Antimicrobial; Antiseptics; Bioburden; Biofilms; Chronic wounds
ID VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS; DIABETIC FOOT; INFECTION;
   BIOFILMS; THERAPY
AB Wounds, especially chronic wounds, represent a global problem costing millions of dollars per year in developed countries and are characterised by microbial complications including local or overt infection, delayed healing and spread of multiresistant germs. Therefore, antimicrobial wound management is a major challenge that continues to require new solutions against microbes and their biofilms. As systemic antibiotics can barely penetrate into wound biofilms and topically applied ones can easily lead to sensitisation, antisepsis is the method of choice to treat germs in wounds. This brief review discusses the role of antiseptics in reducing bioburden in chronic wounds. Balancing antimicrobial potency and tolerability of antiseptic procedures is critical in wound therapy. However, antiseptics alone may not be able to achieve wound healing without addressing other factors regarding the patient's general health or the wound's physical environment. Although the precise role of bioburden in chronic wounds remains to be evaluated, planktonic as well as biofilm-bound microbes are indications for antiseptic intervention. Octenidine dihydrochloride and polyhexanide are the most effective, as well as best tolerated, antiseptics in wound management today, and new strategies to reduce bacterial wound burden and support the body's immune response are being developed.
C1 Ernst Moritz Arndt Univ Greifswald, Dept Dermatol, D-17489 Greifswald, Germany.
C3 Universitat Greifswald
RP Daeschlein, G (通讯作者)，Ernst Moritz Arndt Univ Greifswald, Dept Dermatol, Sauerbruchstr, D-17489 Greifswald, Germany.
EM Georg.daeschlein@uni-greifswald.de
FU Kinetic Concepts, Inc. (KCI); KCI
FX Dr GD presented as a faculty member during the 2012 International
   Surgical Wound Forum (ISWF), an annual educational event sponsored by
   Kinetic Concepts, Inc. (KCI). His article is part of a KCI-funded
   educational supplement based on faculty presentations at 2012 and 2013
   ISWF sessions related to wound care strategies with a focus on use of
   negative pressure wound therapy (V.A.C.(R) Therapy) and negative
   pressure wound therapy with instillation (i.e. V.A.C. Instill (R) Wound
   Therapy and V.A.C. VeraFlo (TM) Therapy). KCI assisted with editorial
   review of the manuscript.
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NR 21
TC 176
Z9 207
U1 0
U2 55
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2013
VL 10
SU 1
SI SI
BP 9
EP 14
DI 10.1111/iwj.12175
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AA3GG
UT WOS:000330980300003
PM 24251838
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Gao, J
   Wang, YL
   Lu, SQ
   Cai, AB
   Yang, ZF
   Han, ZY
   Li, JJ
   Wen, YM
   Geng, FY
   Wang, WZ
AF Gao Ju
   Wang You-li
   Lu Shu-Qiang
   Cai Ai-bing
   Yang Zhi-fu
   Han Zhi-yi
   Li Jiu-jiang
   Wen Yu-ming
   Geng Feng-yong
   Wang Wen-zhang
TI Management of sternal osteomyelitis and mediastinal infection following
   median sternotomy
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE median sternotomy; sternal osteomyelitis; mediastinal infection; muscle
   flaps; management
ID VACUUM-ASSISTED CLOSURE; WOUND-INFECTION; THERAPY; SURVIVAL; IMPACT
AB Background Median sternotomy is considered the most usually performed procedure in cardiac operations. This study aimed to assess clinical effectiveness of bilateral pectoralis major muscle flaps (BPMMF) for management of sternal osteomyelitis and mediastinal infection following median sternotomy.
   Methods Clinical data were collected and retrospectively analyzed from twelve patients who underwent the BPMMF transposition for management of sternal osteomyelitis and mediastinal infection following median sternotomy from January 2006 to June 2009. Procedure consisted of rigorous debridement of necrotic tissues, dead space obliteration using the BPMMF, and placement of drainage tubes connected to a negative pressures generator for adequate drainage.
   Results No patients died of drainage, and all 12 patients had viable BPMMF when discharged from hospital. At 1 week post discharge, 2 patients presented with sternal infection but recovered following local debridement and medication. No patients showed infection recurrence during the follow-up period over 10 months.
   Conclusions Sternal osteomyelitis and mediastinal infection following median sternotomy may be effectively managed through rigorous debridement of infected soft tissues, resection of the damaged stermal segment, transposition of the BPMMF to fill the damaged sternum resulting from debridement, and adequate postoperative drainage. Chin Med J 2010;123(20):2803-2806
C1 [Gao Ju; Wang You-li; Lu Shu-Qiang; Cai Ai-bing; Yang Zhi-fu; Han Zhi-yi; Li Jiu-jiang; Wen Yu-ming; Geng Feng-yong; Wang Wen-zhang] Hosp Aviat Ind Corp China, Dept Surg 3, Beijing 100012, Peoples R China.
C3 Aviation Industry Corporation of China (AVIC)
RP Gao, J (通讯作者)，Hosp Aviat Ind Corp China, Dept Surg 3, Beijing 100012, Peoples R China.
EM gaoju188@sohu.com
RI yang, zhifu/PFR-4063-2026
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   Sachithanandan A, 2008, EUR J CARDIO-THORAC, V33, P673, DOI 10.1016/j.ejcts.2008.01.002
   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   SCHMID DW, 2008, EPLASTY, V43, P419
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjögren J, 2008, INT WOUND J, V5, P216, DOI 10.1111/j.1742-481X.2007.00371.x
   Wong CHK, 2006, EUR J CARDIO-THORAC, V30, P148, DOI 10.1016/j.ejcts.2006.03.049
NR 22
TC 3
Z9 4
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD OCT 20
PY 2010
VL 123
IS 20
BP 2803
EP 2806
DI 10.3760/cma.j.issn.0366-6999.2010.20.010
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 673WF
UT WOS:000283694200010
PM 21034586
DA 2026-07-24
ER

PT J
AU Chan, MCY
   James, C
   Patel, M
   Ellis, S
   Lantis, JC
AF Chan, Mabel Ching-Yee
   James, Crystal
   Patel, Munir
   Ellis, Scott
   Lantis, John C., II
TI The Use of Cellular- and/or Tissue-Based Therapy for the Management of
   Pyoderma Gangrenosum: A Case Series and Review of the Literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE pyoderma gangrenosum; ulcer; skin graft; tissue-based therapy; cellular-
   and/or tissue-based therapy; fetal bovine dermis; surgical intervention;
   debridement
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; SKIN; COMBINATION;
   DIAGNOSIS; ULCERS
AB Pyoderma gangrenosum (PG) is an uncommon inflammatory neutrophilic disorder with a spectrum of clinical presentations with variable courses. Most cases are associated with an autoimmune disorder and manifest in middle-aged adults as a painful lesion that progresses to painful necrotizing ulcers of the lower extremity. Owing to its variability, clinical diagnosis remains difficult and many patients are often misdiagnosed, with resulting delay in treatment. While early immunosuppressant therapy is key to preventing progression of PG, surgical treatment has been met with criticism because of the risk of potentiating pathergy, an exaggerated skin reaction due to trauma. This article presents a case series in which 3 patients with PG lesions underwent different treatment methods, including surgical debridement and use of fetal bovine dermis (FBD). The use of FBD in conjunction with medical treatment provided pain relief and wound coverage as well as encouraged growth of granulation tissue and long-term stability. Commercial cellular and tissue-based products used to aid in accelerating PG wound closure are also reviewed.
C1 [Chan, Mabel Ching-Yee; James, Crystal; Patel, Munir; Ellis, Scott; Lantis, John C., II] Icahn Sch Med Mt Sinai, Morningside & West Hosp, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Chan, MCY (通讯作者)，Mt Sinai Roosevelt Mt Sinai West Med Ctr, Vasc Surg, 425 West 59th St,FL 7, New York, NY 10019 USA.
EM mabel.chan2@mountsinai.org
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NR 38
TC 4
Z9 4
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2021
VL 33
IS 6
BP 161
EP 168
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA TY4YU
UT WOS:000683792300002
PM 34356034
DA 2026-07-24
ER

PT J
AU Vitacolonna, M
   Mularczyk, M
   Herrle, F
   Schulze, TJ
   Haupt, H
   Oechsner, M
   Pilz, LR
   Hohenberger, P
   Rössner, ED
AF Vitacolonna, Mario
   Mularczyk, Michael
   Herrle, Florian
   Schulze, Torsten J.
   Haupt, Hans
   Oechsner, Matthias
   Pilz, Lothar R.
   Hohenberger, Peter
   Roessner, Eric Dominic
TI Effect on the tensile strength of human acellular dermis (Epiflex®) of
   in-vitro incubation simulating an open abdomen setting
SO BMC SURGERY
LA English
DT Article
DE Acellular dermis; Open abdomen; Breaking strength; Biologicals
ID TEMPORARY ABDOMINAL CLOSURE; ABSORBABLE SUTURE MATERIALS;
   VACUUM-ASSISTED CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH; VENTRAL
   HERNIA; MANAGEMENT; PH; MATRIX; DEGRADATION; REPAIR
AB Background: The use of human acellular dermis (hAD) to close open abdomen in the treatment process of severe peritonitis might be an alternative to standard care. This paper describes an investigation of the effects of fluids simulating an open abdomen environment on the biomechanical properties of Epiflex (R) a cell-free human dermis transplant.
   Methods: hAD was incubated in Ringers solution, blood, urine, upper gastrointestinal (upper GI) secretion and a peritonitis-like bacterial solution in-vitro for 3 weeks. At day 0, 7, 14 and 21 breaking strength was measured, tensile strength was calculated and standard fluorescence microscopy was performed.
   Results: hAD incubated in all five of the five fluids showed a decrease in mean breaking strength at day 21 when compared to day 0. However, upper GI secretion was the only incubation fluid that significantly reduced the mechanical strength of Epiflex after 21days of incubation when compared to incubation in Ringer's solution.
   Conclusion: hAD may be a suitable material for closure of the open abdomen in the absence of upper GI leakage and pancreatic fistulae.
C1 [Vitacolonna, Mario; Herrle, Florian; Hohenberger, Peter; Roessner, Eric Dominic] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Surg, Div Surg Oncol & Thorac Surg, D-68167 Mannheim, Germany.
   [Mularczyk, Michael; Haupt, Hans; Oechsner, Matthias] Tech Univ Darmstadt, Chair & Inst Mat Sci IfW, Ctr Struct Mat, State Mat Testing Inst Darmstadt MPA, Darmstadt, Germany.
   [Schulze, Torsten J.] Heidelberg Univ, Med Fac Mannheim, Inst Transfus Med & Immunol, German Red Cross Blood Serv, D-68167 Mannheim, Germany.
   [Pilz, Lothar R.] Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg; Technical University of Darmstadt;
   Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Rössner, ED (通讯作者)，Heidelberg Univ, Univ Med Ctr Mannheim, Dept Surg, Div Surg Oncol & Thorac Surg, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM eric.roessner@umm.de
RI Hohenberger, Peter/MTE-9494-2025; Schulze, Torsten J/JNT-0866-2023
OI Oechsner, Matthias/0000-0003-0248-4232; Roessner, Eric
   Dominic/0000-0003-1173-1098; Schulze, Torsten J/0000-0003-0204-2207;
   Vitacolonna, Mario/0000-0002-8599-1696
FU Deutsche Forschungsgemeinschaft; Ruprecht-Karls-Universitat Heidelberg
FX The authors thank Dr. Mark D. Smith and Dr. Jan C. Brune from the German
   Institute for Cell and Tissue Replacement (DIZG) for advice relating to
   use of Epiflex (R) and for assistance with data analysis and editing of
   the final manuscript. We acknowledge financial support by Deutsche
   Forschungsgemeinschaft and Ruprecht-Karls-Universitat Heidelberg within
   the funding programme Open Access Publishing.
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NR 37
TC 12
Z9 12
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD JAN 27
PY 2014
VL 14
AR 7
DI 10.1186/1471-2482-14-7
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AD2QF
UT WOS:000333079500002
PM 24468201
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Berrevoet, F
   Vanlander, A
   Sainz-Barriga, M
   Rogiers, X
   Troisi, R
AF Berrevoet, F.
   Vanlander, A.
   Sainz-Barriga, M.
   Rogiers, X.
   Troisi, R.
TI Infected large pore meshes may be salvaged by topical negative pressure
   therapy
SO HERNIA
LA English
DT Article
DE Mesh; Infection; Ventral hernia; Negative pressure therapy; Vacuum
   assisted therapy; Large pore
ID VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA; REPAIR; PREVENTION;
   MANAGEMENT; WOUNDS; COMPLICATIONS; RECURRENCE
AB To evaluate the efficacy of negative pressure therapy for superficial and deep mesh infections after ventral and incisional hernia repair by a prospective monocentric observational study.
   During a 6-year period, 724 consecutive open ventral and incisional hernia repairs were performed. Pre- and intraoperative data as well as postoperative complications were prospectively recorded. In case of wound infection, negative pressure therapy (NPT) was our primary treatment.
   Sixty-three patients (8.7 %) were treated using negative pressure therapy after primary ventral and incisional hernia repair. Infectious complications needing NPT occurred in 54 patients in the retromuscular group (54/523; 10.3 %), none when laparoscopically treated and in 9 patients (9/143; 6.3 %) treated by an open intraperitoneal mesh technique. Considering outcome, all meshes were completely salvaged in the retromuscular mesh group after a median of 5 dressing changes (range, 2-9), while in the intraperitoneal mesh, group 3 meshes needed complete (n = 2) or partial (n = 1) excision. Mean duration to complete wound closure was 44 days (range, 26-63 days).
   NPT is a useful adjunct for salvage of deep infected meshes, particularly when large pore monofilament mesh is used.
C1 [Berrevoet, F.; Vanlander, A.; Sainz-Barriga, M.; Rogiers, X.; Troisi, R.] Ghent Univ Hosp & Med Sch, Dept Gen & Hepatobiliary Surg, B-9000 Ghent, Belgium.
   [Berrevoet, F.; Vanlander, A.; Sainz-Barriga, M.; Rogiers, X.; Troisi, R.] Ghent Univ Hosp & Med Sch, Liver Transplantat Serv, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital; Ghent University; Ghent
   University Hospital
RP Berrevoet, F (通讯作者)，Ghent Univ Hosp & Med Sch, Dept Gen & Hepatobiliary Surg, De Pintelaan 185 2K12 IC, B-9000 Ghent, Belgium.
EM Frederik.Berrevoet@ugent.be
RI Sainz-Barriga, Mauricio/A-6456-2009; Troisi, Roberto/E-8737-2015;
   Berrevoet, Frederik/A-6117-2008; Vanlander, Aude/AAP-3342-2021
OI Sainz-Barriga, Mauricio/0000-0002-9981-4340; 
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NR 32
TC 58
Z9 66
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD FEB
PY 2013
VL 17
IS 1
BP 67
EP 73
DI 10.1007/s10029-012-0969-3
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 081BT
UT WOS:000314291300010
PM 22836918
OA Green Published
DA 2026-07-24
ER

PT J
AU Wong, VW
   Akaishi, S
   Longaker, MT
   Gurtner, GC
AF Wong, Victor W.
   Akaishi, Satoshi
   Longaker, Michael T.
   Gurtner, Geoffrey C.
TI Pushing Back: Wound Mechanotransduction in Repair and Regeneration
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; HYPERTROPHIC SCAR FORMATION; MICROVASCULAR
   BLOOD-FLOW; STEM-CELL FATE; RED DUROC PIG; MECHANICAL-PROPERTIES;
   EXTRACELLULAR-MATRIX; SYSTEMIC-SCLEROSIS; GENE-EXPRESSION; FIBROBLAST
   PROLIFERATION
AB Human skin is a highly specialized mechanoresponsive interface separating our bodies from the external environment. It must constantly adapt to dynamic physical cues ranging from rapid expansion during embryonic and early postnatal development to ubiquitous external forces throughout life. Despite the suspected role of the physical environment in cutaneous processes, the fundamental molecular mechanisms responsible for how skin responds to force remain unclear. Intracellular pathways convert mechanical cues into biochemical responses (in a process known as mechanotransduction) via complex mechanoresponsive elements that often blur the distinction between physical and chemical signaling. For example, cellular focal adhesion components exhibit dual biochemical and scaffolding functions that are critically modulated by force. Moreover, the extracellular matrix itself is increasingly recognized to mechanically regulate the spatiotemporal distribution of soluble and matrix-bound ligands, underscoring the importance of bidirectional crosstalk between cells and their physical environment. It seems likely that a structural hierarchy exists to maintain both cells and matrix in mechanical homeostasis and that dysregulation of this architectural integrity may underlie or contribute to various skin disorders. An improved understanding of these interactions will facilitate the development of novel biophysical materials and mechanomodulatory approaches to augment wound repair and regeneration.
C1 [Wong, Victor W.; Akaishi, Satoshi; Longaker, Michael T.; Gurtner, Geoffrey C.] Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA.
C3 Stanford University
RP Gurtner, GC (通讯作者)，Stanford Univ, Sch Med, Dept Surg, 257 Campus Dr, Stanford, CA 94305 USA.
EM ggurtner@stanford.edu
OI Longaker, Michael/0000-0003-1430-8914
FU Wallace H Coulter Translational Partners grant; United States Armed
   Forces Institute of Regenerative Medicine (DOD) [W81XWA0-08-2-0032];
   Hagey Family Endowed Fund in Stem Cell Research and Regenerative
   Medicine; Oak Foundation; Uehara Memorial Foundation
FX Work related to this article was supported by a Wallace H Coulter
   Translational Partners grant (to MTL and GCG), a United States Armed
   Forces Institute of Regenerative Medicine grant (DOD no.
   W81XWA0-08-2-0032; to MTL and GCG), the Hagey Family Endowed Fund in
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   Oak Foundation (to MTL and GCG), and the Uehara Memorial Foundation (to
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NR 127
TC 164
Z9 226
U1 1
U2 48
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-202X
EI 1523-1747
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD NOV
PY 2011
VL 131
IS 11
BP 2186
EP 2196
DI 10.1038/jid.2011.212
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 837WP
UT WOS:000296240100012
PM 21776006
DA 2026-07-24
ER

PT J
AU Jordana, M
   Pint, E
   Martens, A
AF Jordana, M.
   Pint, E.
   Martens, A.
TI The use of vacuum-assisted wound closure to enhance skin graft
   acceptance in a horse
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Article
ID MANAGEMENT
AB A 16-year-old horse was admitted to the clinic of the Department of Surgery and Anesthesiology of Domestic Animals of the Faculty of Veterinary Medicine (Ghent University) for the treatment of a very large, non-healing wound extending over the dorsomedial and dorsolateral aspects of the left metatarsus. Surgical debridement of exuberant granulation tissue and new bone was performed under general anesthesia, followed by standard wound care under a bandage. Once a new bed of healthy granulation had formed, skin grafting was performed using the punch graft method. Due to the presence of a significant amount of wound exudate, cast immobilization was considered to be contraindicated. Instead, vacuum-assisted closure (VAC) therapy was used as a method of securing the skin grafts to the wound bed during the first days post-operatively. After five days of VAC therapy, the wound dressing was removed and an acceptance of nearly 100% of the punch grafts was observed. Complete epithelialization of the wound was evident 42 days after skin grafting. As far as the authors know, this is the first report describing the use of VAC therapy as a method of wound management in combination with punch grafting on the distal limb of a horse.
C1 [Jordana, M.; Pint, E.; Martens, A.] Univ Ghent, Dept Surg & Anesthesiol Domest Anim, Fac Vet Med, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP Jordana, M (通讯作者)，Univ Ghent, Dept Surg & Anesthesiol Domest Anim, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM mireia.jordanagarcia@ugent.be
RI ; Jordana, Mireia/AAD-8980-2022
OI Martens, Ann/0000-0001-9554-4841; 
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NR 16
TC 17
Z9 18
U1 1
U2 30
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD SEP-OCT
PY 2011
VL 80
IS 5
BP 343
EP 350
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 842JS
UT WOS:000296596100004
DA 2026-07-24
ER

PT J
AU Ghosh, K
   Ingber, DE
AF Ghosh, Kaustabh
   Ingber, Donald E.
TI Micromechanical control of cell and tissue development: Implications for
   tissue engineering
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE tissue engineering; Cell-ECM interface; tissue development; scaffold
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE;
   BRANCHING MORPHOGENESIS; ENDOTHELIAL-CELLS;
   MORPHOLOGICAL-DIFFERENTIATION; MECHANICAL-PROPERTIES; GEOMETRIC CONTROL;
   LIVING CELLS; STEM-CELLS
AB Tissue engineering approaches for repair of diseased or lost organs will require the development of new biomaterials that guide cell behavior and seamlessly integrate with living tissues. Previous approaches to engineer artificial tissues have focused largely on optimization of scaffold polymer chemistry and selection of appropriate biochemical additives (e.g., growth factors, adhesive ligands) to provide effective developmental control. However, recent work has shown that micromechanical forces and local variations of extracellular matrix (ECM) elasticity at the microscale regulate cell and tissue development both in vitro and in vivo. The micromechanical properties of the host tissue microenvironment also play a critical role in control of stem cell lineage switching. Here we discuss how new understanding of the fundamental role that mechanical forces play in tissue development might be leveraged to facilitate the development of new types of biomimetic materials for regenerative medicine, with a focus on the design of injectable materials that can target to injury sites, recruit stem cells and direct cellular self-assembly to regenerate functional tissues and organs in situ. (C) 2007 Published by Elsevier B.V.
C1 [Ghosh, Kaustabh; Ingber, Donald E.] Childrens Hosp, Harvard Med Sch, Dept Pathol & Surg, Vasc Biol Program, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard Medical School
RP Ingber, DE (通讯作者)，Childrens Hosp, Harvard Med Sch, Dept Pathol & Surg, Vasc Biol Program, 300 Longwood Ave, Boston, MA 02115 USA.
EM donald.ingber@childrens.harvard.edu
RI ; Ingber, Donald/AAC-5894-2019
OI GHOSH, KAUSTABH/0000-0001-8185-9180; 
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NR 113
TC 175
Z9 218
U1 0
U2 55
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD NOV 10
PY 2007
VL 59
IS 13
BP 1306
EP 1318
DI 10.1016/j.addr.2007.08.014
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 242YP
UT WOS:000251762400004
PM 17920155
DA 2026-07-24
ER

PT J
AU Bellows, CF
   Albo, D
   Berger, DH
   Awad, SS
AF Bellows, Charles F.
   Albo, Daniel
   Berger, David H.
   Awad, Samir S.
TI Abdominal wall repair using human acellular dermis
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE abdominal wall reconstruction; human acellular dermis; biologic tissue
   graft
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; LONG-TERM
   COMPLICATIONS; POLYPROPYLENE MESH; INCISIONAL HERNIA; VENTRAL HERNIA;
   WOUND THERAPY; DEFECTS; RECONSTRUCTION; RISK
AB Background: The surgical repair of abdominal wall defects that cannot be closed primarily in contaminated fields is a difficult problem. The use of nonabsorbable synthetic'materials usually is contraindicated in this setting because of the risk for colonization and chronic infection of the mesh. In this study we sought to determine the safety and efficacy of implanted human acellular dermal graft for abdominal wall reconstruction.
   Methods: The records of all patients (n 20) who underwent a repair of an abdominal wall defect with human acellular dermal graft at a Veteran Affairs hospital were reviewed retrospectively. Patient demographics, complications, and hernia recurrence were recorded.
   Results: There were 15 perioperative complications in I I patients: 6 graft dehiscences, I evisceration, 2 postoperative intra-abdominal bleeds, 5 bacteria] graft infections, and I death. Patients with heart disease, American Society of Anesthesiologists classification of 4, and/or dirty wounds were more likely to have perioperative complications. The median follow-up period was 9.4 months (range, 2-16 mo), during which 6 hernia recurrences were noted.
   Conclusions: Human acellular dermis use is safe in abdominal wall reconstructions in contaminated surgical wounds. (C) 2007 Excerpta Medica Inc. All rights reserved.
C1 Michael E DeBakey Vet Affairs Hosp, Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Bellows, CF (通讯作者)，Michael E DeBakey Vet Affairs Hosp, Baylor Coll Med, Michael E DeBakey Dept Surg, M-C 112,2002 Holcombe Blvd, Houston, TX 77030 USA.
EM cbellows@bcm.tmc.edu
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NR 40
TC 96
Z9 108
U1 0
U2 4
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2007
VL 194
IS 2
BP 192
EP 198
DI 10.1016/j.amjsurg.2006.11.012
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 191DS
UT WOS:000248110900012
PM 17618803
DA 2026-07-24
ER

PT J
AU Miller, MC
   Nanchahal, J
AF Miller, MC
   Nanchahal, J
TI Advances in the modulation of cutaneous wound healing and scarring
SO BIODRUGS
LA English
DT Review
ID GROWTH-FACTOR-BETA; VACUUM-ASSISTED CLOSURE; EXTREMITY DIABETIC ULCERS;
   ACUTE INCISIONAL WOUNDS; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   GRANULATION-TISSUE FORMATION; KELOID-DERIVED FIBROBLASTS; MEDIATED
   GENE-TRANSFER; TOPICAL SILICONE GEL; SMOOTH MUSCLE ACTIN
AB Cutaneous wounds inevitably heal with scars, which can be disfiguring and compromise function. In general, the greater the insult, the worse the scarring, although genetic make up, regional variations and age can influence the final result. Excessive scarring manifests as hypertrophic and keloid scars. At the other end of the spectrum are poorly healing chronic wounds, such as foot ulcers in diabetic patients and pressure sores. Current therapies to minimize scarring and accelerate wound healing rely on the optimization of systemic conditions, early wound coverage and closure of lacerations, and surgical incisions with minimal trauma to the surrounding skin. The possible benefits of topical therapies have also been assessed. Further major improvements in wound healing and scarring require an understanding of the molecular basis of this process. Promising strategies for modulating healing include the local administration of platelet derived growth factor (PDGF)-BB to accelerate the healing of chronic ulcers, and increasing the relative ratio of transforming growth factor (TGF)beta-3 to TGF beta-1 and TGF beta-2 in order to minimize scarring.
C1 Univ Sydney, Dept Hand Surg, Royal N Shore Hosp, St Leonards, NSW 2065, Australia.
   Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol, London, England.
C3 University of Sydney; Royal North Shore Hospital; Imperial College
   London; University of Oxford; Kennedy Institute for Rheumatology
RP Nanchahal, J (通讯作者)，Univ Sydney, Dept Hand Surg, Royal N Shore Hosp, St Leonards, NSW 2065, Australia.
EM jagdeepn@med.usyd.ed.au
OI Nanchahal, Jagdeep/0000-0002-9579-9411
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NR 191
TC 74
Z9 99
U1 0
U2 21
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1173-8804
EI 1179-190X
J9 BIODRUGS
JI Biodrugs
PY 2005
VL 19
IS 6
BP 363
EP 381
DI 10.2165/00063030-200519060-00004
PG 19
WC Oncology; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Immunology; Pharmacology & Pharmacy
GA 004CU
UT WOS:000234730400003
PM 16392889
DA 2026-07-24
ER

PT J
AU Binda, C
   Jung, CFM
   Fabbri, S
   Giuffrida, P
   Sbrancia, M
   Coluccio, C
   Gibiino, G
   Fabbri, C
AF Binda, Cecilia
   Jung, Carlo Felix Maria
   Fabbri, Stefano
   Giuffrida, Paolo
   Sbrancia, Monica
   Coluccio, Chiara
   Gibiino, Giulia
   Fabbri, Carlo
TI Endoscopic Management of Postoperative Esophageal and Upper GI Defects-A
   Narrative Review
SO MEDICINA-LITHUANIA
LA English
DT Review
DE endoscopic treatment of anastomotic defects; esophageal fistula;
   perforation; esophageal leakage
ID VACUUM-ASSISTED CLOSURE; SLEEVE GASTRECTOMY; INTERNAL DRAINAGE;
   BARIATRIC SURGERY; ANASTOMOTIC LEAKAGE; GASTRIC LEAKS; MULTICENTER
   EXPERIENCE; ENDOSPONGE THERAPY; STENT; BENIGN
AB Anastomotic defects are deleterious complications after either oncologic or bariatric surgery, leading to high morbidity and mortality. Besides surgical revision in early stages or instable patients, endoscopic treatment has become the mainstay. To date, many options for endoscopic treatment in this setting exist, including fully covered metal stent placement, endoscopic vacuum therapy (EVT), endoscopic internal drainage with pigtail placement (EID), leak closure with through the scope or over the scope clips, endoluminal suturing, fibrin glue sealing and a combination of all these techniques. Current evidence is mostly based on retrospective single and multicenter studies. No guidelines exist in this important field. Treatment options have to be chosen upon each case individually, taking into account clinical and anatomic criteria, such as timing, size, infectious wound complications and hemodynamic stability. Local expertise and availability of treatment devices need to be taken into account whenever choosing a treatment strategy. This review aimed to present current treatment options in terms of effectiveness, advantages and disadvantages in order to guide the clinician for his decision making. Additionally, we aimed to provide a treatment algorithm.
C1 [Binda, Cecilia; Jung, Carlo Felix Maria; Fabbri, Stefano; Sbrancia, Monica; Coluccio, Chiara; Gibiino, Giulia; Fabbri, Carlo] Forli Cesena Hosp, Gastroenterol & Digest Endoscopy Unit, AUSL Romagna, I-47121 Forli, Italy.
   [Giuffrida, Paolo] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, PROMISE, I-90127 Palermo, Italy.
C3 AUSL della Romagna; University of Palermo
RP Binda, C (通讯作者)，Forli Cesena Hosp, Gastroenterol & Digest Endoscopy Unit, AUSL Romagna, I-47121 Forli, Italy.
EM cecilia.binda@gmail.com
RI Giuffrida, Paolo/AER-7895-2022; Gibiino, Giulia/AAC-6655-2022; Binda,
   Cecilia/ABH-1588-2020
OI Giuffrida, Paolo/0000-0002-4628-1130; Fabbri,
   Stefano/0000-0003-2125-7588; Gibiino, Giulia/0000-0003-2211-6322; 
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   Wedemeyer J, 2008, GASTROINTEST ENDOSC, V67, P708, DOI 10.1016/j.gie.2007.10.064
   Wedi E, 2018, ENDOSCOPY, V50, pE69, DOI 10.1055/s-0043-124180
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NR 105
TC 20
Z9 22
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JAN
PY 2023
VL 59
IS 1
AR 136
DI 10.3390/medicina59010136
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8Q4DG
UT WOS:000927158700001
PM 36676760
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Catarino, PA
   Chamberlain, MH
   Wright, NC
   Black, E
   Campbell, K
   Robson, D
   Pillai, RG
AF Catarino, PA
   Chamberlain, MH
   Wright, NC
   Black, E
   Campbell, K
   Robson, D
   Pillai, RG
TI High-pressure suction drainage via a polyurethane foam in the management
   of poststernotomy mediastinitis
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID CORONARY-ARTERY BYPASS; STERNAL WOUND COMPLICATIONS; VACUUM-ASSISTED
   CLOSURE; MEDIAN STERNOTOMY; INFECTIONS; SURGERY
AB Background. This study was performed to evaluate the effectiveness of suction drainage in the management of early poststernotomy mediastinitis.
   Methods. From September 1998 to August 1999, we encountered nine cases of poststernotomy mediastinitis out of 1,209 adult median sternotomies performed in this time period. All these cases were treated with suction drainage, which was recently introduced to our management protocol. From September 1997 to August 1998, we encountered 11 cases of poststernotomy mediastinitis of 1,343 adult median sternotomies. All these cases were initially treated by closed drainage and irrigation, which was our previous first-line management. We used the latter group as historical controls for the evaluation of suction drainage. Lengths of hospitalization were compared using the Mann-Whitney U test, and success versus failure of the primary treatment was compared using the chi (2) test.
   Results. Treatment with the suction dressing resulted in a decreased length of hospitalization after treatment starts (p = 0.02) and a lower rate of treatment failure (p = 0.03).
   Conclusions. The use of high-pressure suction drainage is a valuable adjunct in the early management of poststernotomy mediastinitis. (Ann Thorac Surg 2000;70:1891-5) (C) 2000 by The Society of Thoracic Surgeons.
C1 John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England.
C3 University of Oxford
RP Catarino, PA (通讯作者)，John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England.
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NR 20
TC 42
Z9 49
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0003-4975
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD DEC
PY 2000
VL 70
IS 6
BP 1891
EP 1895
DI 10.1016/S0003-4975(00)02173-1
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 385UT
UT WOS:000166022900029
PM 11156090
OA Bronze
DA 2026-07-24
ER

PT J
AU Yoshino, D
   Sato, K
   Sato, M
AF Yoshino, Daisuke
   Sato, Kakeru
   Sato, Masaaki
TI Endothelial Cell Response Under Hydrostatic Pressure Condition Mimicking
   Pressure Therapy
SO CELLULAR AND MOLECULAR BIOENGINEERING
LA English
DT Article
DE Positive pressure; Negative pressure; Endothelial morphology; Cellular
   area; Cell density; Cell cycle; Proliferation
ID VACUUM-ASSISTED CLOSURE; PROLIFERATION; MORPHOLOGY; MIGRATION; CADHERIN
AB Chronic wounds increase the risk of infection and may lead to complications or disease. Although treatment techniques involving topical negative pressure have been used widely to promote wound healing, the relationship between promotion of wound healing and negative pressure remains unclear. In the present study, we studied the effects of hydrostatic pressure (HP) on endothelial cells (ECs) during pressure treatment. We examined the morphologic and functional responses of ECs to HP using an experimental system developed to apply both negative and positive pressure to ECs. Morphologic parameters such as aspect ratio, orientation angle, and tortuosity did not change after exposure to HP for up to 24 h. In contrast, application of HP led to significant changes in cell area and cell density, and the formation of intercellular gaps was observed as early as 3 h before the cell density reached its peak value. We also found HP progressed EC cycle, which remained at rest according to contact inhibition. Although there were some differences with respect to trends in changes in those parameters, positive and negative pressures had similar effects on ECs. Considering the results of this study, we conclude that exposure to HP enhances the proliferation of ECs.
C1 [Yoshino, Daisuke] Tohoku Univ, Inst Fluid Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan.
   [Sato, Kakeru] Tohoku Univ, Grad Sch Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan.
   [Sato, Masaaki] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan.
   [Sato, Kakeru] Tokyo Gas Co Ltd, Minato Ku, Tokyo 1058527, Japan.
C3 Tohoku University; Tohoku University; Tohoku University; Tokyo Gas Co.,
   Ltd.
RP Yoshino, D (通讯作者)，Tohoku Univ, Inst Fluid Sci, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan.
EM yoshino.d@m.tohoku.ac.jp
RI Yoshino, Daisuke/IXN-3988-2023
OI Yoshino, Daisuke/0000-0002-2948-1210
CR [Anonymous], 2008, COCHRANE DATABASE SY
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 22
Z9 23
U1 0
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1865-5025
EI 1865-5033
J9 CELL MOL BIOENG
JI Cell. Mol. Bioeng.
PD JUN
PY 2015
VL 8
IS 2
BP 296
EP 303
DI 10.1007/s12195-015-0385-8
PG 8
WC Cell & Tissue Engineering; Biophysics; Cell Biology; Engineering,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biophysics; Engineering
GA CH4ET
UT WOS:000353986500007
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Johansson, M
   Hlebowicz, J
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Johansson, Malin
   Hlebowicz, Joanna
   Malmsjo, Malin
   Ingemansson, Richard
TI Myocardial topical negative pressure increases blood flow in
   hypothermic, ischemic myocardium
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE topical negative pressure (TNP); microvascular blood flow; ischemia;
   hypothermia
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; LASER DOPPLER
   FLOWMETRY; PERISTERNAL THORACIC WALL; LONG-TERM SURVIVAL; POSTSTERNOTOMY
   MEDIASTINITIS; THERAPEUTIC HYPOTHERMIA; CARDIOPULMONARY BYPASS;
   ANGINA-PECTORIS; PORCINE HEART
AB Objectives. Hypothermia protects the myocardium from oxidative injury during ischemic stress and reperfusion. We have previously shown that topical negative pressure (TNP) of -50 mmHg significantly increases microvascular blood flow in the underlying myocardium in normal, ischemic, and reperfused porcine myocardium. The present study was designed to elucidate the effect of TNP between -50 mmHg and -150 mmHg on microvascular blood flow in ischemic myocardium during hypothermia. Design. The microvascular blood flow in the myocardium was recorded, in seven pigs, using laser Doppler velocimetry. Analyses were performed in the epicardium and in the myocardium, after 40 minutes of occlusion of the LAD followed by cooling to 31 degrees C. Results. A TNP of -50 mmHg applied to the epicardium, from 23.3 +/- 3.8 PU to 104.2 +/- 31.3 PU (*p<0.05), and in the myocardium, from 35.0 +/- 7.2 PU to 74.2 +/- 21.8 PU (*p<0.05). Conclusions. Only a TNP level of -50 mmHg significantly increased the microvascular blood flow in both the epicardium and in the myocardium during hypothermia.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Hlebowicz, Joanna; Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 44
TC 3
Z9 3
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2008
VL 42
IS 5
BP 345
EP 353
DI 10.1080/14017430801939225
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 349YE
UT WOS:000259318400009
PM 18609061
OA Bronze
DA 2026-07-24
ER

PT J
AU Hadamitzky, CD
   Schulte, S
   Horsch, S
AF Hadamitzky, C. Domingos
   Schulte, S.
   Horsch, S.
TI Vacuum assisted wound closure in postoperative periprosthetic groin
   infections: a new gold standard?
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE postoperative complications; infections; vacuum assisted closure; wound
   infection
ID SARTORIUS MYOPLASTY; NEGATIVE-PRESSURE; VASCULAR GRAFTS; MANAGEMENT;
   THERAPY
AB Aim This study was designed to control the results of conservative treatment using vacuum assisted wound closure (VAWC) applied exclusively to cases of deep groin infections with involvement of alloplastic graft material.
   Methods. During a 2 year period 10 patients with 11 deep inguinal infections involving alloplastic graft material were treated with supportive VAWC. Intraoperative management included extensive debridement, sartorius myoplastic and VAWC application. A retrospective case-note review was performed. Variables comorbidity, surgical management of the infection, microbiological results, complications and Doppler results were analysed.
   Results. Six early graft infections (< 30 days after implantation) and 5 late infections were treated. In 3 cases (27.3%) the infected graft material was replaced by a silver-coated Dacron prosthesis. The mean duration of VAWC was 16 +/- 7.7 days; postoperative mean hospital stay was 25.3 +/- 8.5 days. Mean postoperative follow-up was 13.1 months with no procedure-related mortality.
   Conclusion Even in the presence of synthetic vascular graft material, negative pressure therapy can greatly simplify challenging wound healing problems under maintenance of the alloplastic grafts. These preliminary results demonstrate the safety and effectiveness of VAWC for the treatment of deep alloplastic graft infections.
C1 Univ Cologne, Dept Vasc Surg, Hosp Porz Rhein, D-51149 Cologne, Germany.
C3 University of Cologne
RP Hadamitzky, CD (通讯作者)，Univ Cologne, Dept Vasc Surg, Hosp Porz Rhein, Urbacher Weg 19, D-51149 Cologne, Germany.
EM c.hadamitzky@btinternet.com
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NR 18
TC 16
Z9 16
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD AUG
PY 2007
VL 48
IS 4
BP 477
EP 483
PG 7
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 229WN
UT WOS:000250837000008
PM 17653008
DA 2026-07-24
ER

PT J
AU van Wingerden, JJ
   Ubbink, DT
   van der Horst, CMAM
   de Mol, BAJM
AF van Wingerden, Jan J.
   Ubbink, Dirk T.
   van der Horst, Chantal M. A. M.
   de Mol, Bas A. J. M.
TI Poststernotomy mediastinitis: a classification to initiate and evaluate
   reconstructive management based on evidence from a structured review
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Review
DE Classification; Infection; Mediastinitis; Mediastinal infection;
   Outcomes; Poststernotomy; Postoperative; Sternal infection; Wound
   infection
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND INFECTIONS; MUSCLE FLAP
   RECONSTRUCTION; NEGATIVE-PRESSURE THERAPY; MRSA MEDIASTINITIS;
   CARDIAC-SURGERY; OMENTAL-FLAP; CARDIOTHORACIC SURGERY; PECTORALIS FLAPS;
   GREATER OMENTUM
AB Early recognition and, where possible, avoidance of risk factors that contribute to the development of poststernotomy mediastinitis (PSM) form the basis for successful prevention. Once the presence of PSM is diagnosed, the known risk factors have been shown to have limited influence on management decisions. Evidence-based knowledge on treatment decisions, which include the extent and type of surgical intervention (other than debridement), timing and others is available but has not yet been incorporated into a classification on management decisions regarding PSM. Ours is a first attempt at developing a classification system for management of PSM, taking the various evidence-based reconstructive options into consideration. The classification is simple to introduce (there are four Types) and relies on the careful establishment of two variables (sternal stability and sternal bone viability and stock) prior to deciding on the best available reconstructive option. It should allow better insight into why treatment decisions fail or have to be altered and will allow better comparison of treatment outcomes between various institutions.
C1 [van Wingerden, Jan J.; van der Horst, Chantal M. A. M.] Univ Amsterdam, Acad Med Ctr, Dept Plast & Reconstruct Surg, NL-1100 DD Amsterdam, Netherlands.
   [Ubbink, Dirk T.] Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, NL-1105 AZ Amsterdam, Netherlands.
   [de Mol, Bas A. J. M.] Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam
RP van Wingerden, JJ (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Plast & Reconstruct Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM j.j.vanwingerden@amc.uva.nl
RI ; Ubbink, Dirk/AAF-1266-2021
OI van der Horst, chantal/0000-0002-4937-3786; de Mol,
   Bastian/0000-0001-6888-9430; Ubbink, Dirk/0000-0001-9398-8879
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NR 84
TC 40
Z9 49
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD NOV 23
PY 2014
VL 9
AR 179
DI 10.1186/s13019-014-0179-4
PG 9
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AW7KD
UT WOS:000346442100001
PM 25417190
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lo Torto, F
   Turriziani, G
   Donato, C
   Marcasciano, M
   Redi, U
   Greco, M
   Miraldi, F
   Ribuffo, D
AF Lo Torto, Federico
   Turriziani, Gianmarco
   Donato, Casella
   Marcasciano, Marco
   Redi, Ugo
   Greco, Manfredi
   Miraldi, Fabio
   Ribuffo, Diego
TI Deep sternal wound infection following cardiac surgery: A comparison of
   the monolateral with the bilateral pectoralis major flaps
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE negative pressure therapy; pectoralis major muscle flap; sternal wound
   infection
ID VACUUM-ASSISTED CLOSURE; RECTUS-ABDOMINIS MUSCLE; SURGICAL SITE
   INFECTION; LONG-TERM SURVIVAL; OPEN-HEART-SURGERY; MEDIAN STERNOTOMY;
   RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; RECONSTRUCTION; MANAGEMENT
AB Deep sternal wound infections are a serious complication following sternotomy for cardiothoracic surgery. "Conventional" treatment provides debridement and secondary closure or closed catheter irrigation. The combination of the Negative Pressure Therapy with flap coverages is an accepted technique and one or both Pectoralis Major muscles could be chosen. A multistep protocol was adopted. One hundred and sixty seven patients were treated with the combination of Negative Pressure Therapy with the Pectoralis Major muscle flap: 86 monolateral flap and 81 bilateral flap reconstruction. The main complications (hematoma, seroma, dehiscence, and re-infection), the need for re-intervention, mortality rates, Intensive Care Unit, and hospitalisation time were assessed. The mono-pectoralis group had fewer complications and need for revision, with a shorter hospital stay. A statistically significant difference emerged for the hematoma rate (P = .0079). Monolateral flap should to be preferred because with the same coverage effectiveness, it guarantees the saving of controlateral muscle with its functionality and the possibility of its use in case of failure. Furthermore, as the technique is less invasive, it can be reserved for more fragile patients.
C1 [Lo Torto, Federico; Turriziani, Gianmarco; Marcasciano, Marco; Redi, Ugo; Ribuffo, Diego] Sapienza Univ Roma, Dept Plast Reconstruct & Aesthet Surg, Rome, Italy.
   [Donato, Casella] Azienda Osped Univ Senese, Dept Breast Canc Surg, Siena, Italy.
   [Greco, Manfredi] Magna Graecia Univ Catanzaro, Catanzaro, Italy.
   [Miraldi, Fabio] Sapienza Univ Roma, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy.
C3 Sapienza University Rome; University of Siena; University Hospital of
   Siena; Magna Graecia University of Catanzaro; Sapienza University Rome
RP Turriziani, G (通讯作者)，Via Piede la Valle 13, I-03030 Broccostella, Italy.
EM gianmarco.turriziani@gmail.com
RI GRECO, Manfredi/HZJ-5764-2023; turriziani, gianmarco/HKN-2908-2023;
   RIBUFFO, Diego/HLG-3305-2023; Torto, Federico/AAY-1852-2021;
   Marcasciano, Marco/HZJ-0259-2023
OI GRECO, Manfredi/0000-0001-6886-0160; turriziani,
   gianmarco/0000-0003-3172-5568; RIBUFFO, Diego/0000-0002-1844-7850;
   Casella, Donato/0000-0003-3946-2029
FU KCI Concepts, Inc
FX No contributions, technical help, financial and material support were
   provided by "V.A.C. ATS Therapy System, KCI Concepts, Inc, San Antonio,
   TX" or by others.
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NR 82
TC 18
Z9 21
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 683
EP 691
DI 10.1111/iwj.13324
EA FEB 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000513737600001
PM 32065728
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Johnson, LS
   Chaar, M
   Ball, CG
   Perez, S
   Nicholas, JM
   Wyrzykowski, AD
   Rozycki, GS
   Feliciano, DV
   Dente, CJ
AF Johnson, Laura S.
   Chaar, Mitchell
   Ball, Chad G.
   Perez, Sebastian
   Nicholas, Jeffrey M.
   Wyrzykowski, Amy D.
   Rozycki, Grace S.
   Feliciano, David, V
   Dente, Christopher J.
TI Management of extremity fasciotomy sites prospective randomized
   evaluation of two techniques
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Fasciotomy; Shoelace technique; Wound closure; Vacuum-assisted closure
ID DELAYED PRIMARY CLOSURE; ACUTE COMPARTMENT SYNDROME; VESSEL LOOP
   SHOELACE; WOUND CLOSURE; ASSISTED CLOSURE; GRADUAL CLOSURE; DEVICE
AB Introduction: Morbidity from the treatment of extremity compartment syndrome is underappreciated. Closure technique effectiveness has yet to be definitively established.
   Methods: A randomized non-blinded prospective study was performed involving patients who underwent an extremity fasciotomy following trauma. Shoelace wounds were strapped with vessel loops under tension and VAC wounds were treated with a standard KCI VAC dressing. After randomization, patients returned to the OR every 96 h until primarily closed or skin grafted.
   Results: 21 patients were consented for randomization with 11 (52%) successfully closed at the first reoperation. After interim analysis the study was closed early with 5/5 (100%) of wounds treated with the shoelace technique closed primarily and only 1/9 (11%) of VAC wounds closed primarily (p = 0.003). Overall primary closure was achieved in 74% of patients.
   Conclusions: Aggressive attempts at wound closure lead to an increased early closure rate. For wounds that remain open after the first re-operation, a simple shoelace technique is more successful than a wound VAC for achieving same hospital stay skin closure. (c) 2018 Elsevier Inc. All rights reserved.
C1 [Johnson, Laura S.] Medstar Washington Hosp Ctr, Washington, DC 20010 USA.
   [Chaar, Mitchell] Jersey City Med Ctr, Jersey City, NJ USA.
   [Ball, Chad G.] Univ Calgary, Calgary, AB, Canada.
   [Nicholas, Jeffrey M.] Gwinnett Med Ctr, Lawrenceville, GA USA.
   [Wyrzykowski, Amy D.] Wellstar Med Grp, Atlanta, GA USA.
   [Rozycki, Grace S.] Indiana Univ, Indianapolis, IN 46204 USA.
   [Feliciano, David, V] Univ Maryland, Sch Med, Dept Surg, Shock Trauma Ctr, Baltimore, MD 21201 USA.
   [Johnson, Laura S.; Chaar, Mitchell; Ball, Chad G.; Perez, Sebastian; Nicholas, Jeffrey M.; Wyrzykowski, Amy D.; Rozycki, Grace S.; Feliciano, David, V; Dente, Christopher J.] Emory Univ, Sch Med, Grady Mem Hosp, Atlanta, GA USA.
   [Johnson, Laura S.; Chaar, Mitchell; Ball, Chad G.; Perez, Sebastian; Nicholas, Jeffrey M.; Wyrzykowski, Amy D.; Rozycki, Grace S.; Feliciano, David, V; Dente, Christopher J.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
C3 MedStar Washington Hospital Center; University of Calgary; Indiana
   University System; Indiana University Indianapolis; University System of
   Maryland; University of Maryland Baltimore; Emory University; Emory
   University
RP Johnson, LS (通讯作者)，Medstar Washington Hosp Ctr, Burn Ctr, 110 Irving St NW 3B-55, Washington, DC 20010 USA.
EM laura.s.johnson@medstar.net; mitch_chaar@yahoo.com; ball.chad@gmail.com;
   sdperez@emory.edu; jnicholas@gwinnettmedicalgroup.com;
   amy.wyrzykowski@wellstar.org; grace.rozycki@att.net;
   davidfelicianomd@gmail.com; cdente@emory.edu
RI Johnson, Laura S/ABE-5478-2020
OI Johnson, Laura S/0000-0001-6969-2648
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NR 26
TC 10
Z9 13
U1 0
U2 6
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD OCT
PY 2018
VL 216
IS 4
BP 736
EP 739
DI 10.1016/j.amjsurg.2018.07.033
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GV9DG
UT WOS:000446453700015
PM 30064725
DA 2026-07-24
ER

PT J
AU Regner, JL
   Kobayashi, L
   Coimbra, R
AF Regner, Justin L.
   Kobayashi, Leslie
   Coimbra, Raul
TI Surgical Strategies for Management of the Open Abdomen
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; DAMAGE-CONTROL
   LAPAROTOMY; PRIMARY FASCIAL CLOSURE; INTRAABDOMINAL HYPERTENSION; TRAUMA
   PATIENTS; WOUND CLOSURE; TEMPORARY CLOSURE; VENTRAL HERNIA; PACK
   TECHNIQUE
AB Since the mid-1990s the surgical community has seen a surge in the prevalence of open abdomens (OAs) reported in the surgical literature and in clinical practice. The OA has proven to be effective in decreasing mortality and immediate postoperative complications; however, it may come at the cost of delayed morbidity and the need for further surgical procedures. Indications for leaving the abdomen open have broadened to include damage control surgery, abdominal compartment syndrome, and abdominal sepsis. The surgical options for management of the OA are now more diverse and sophisticated, but there is a lack of prospective randomized controlled trials demonstrating the superiority of any particular method. Additionally, critical care strategies for optimization of the patient with an OA are still being developed. Review of the literature suggests a bimodal distribution of primary closure rates, with early closure dependent on postoperative intensive care management and delayed closure more affected by the choice of the temporary abdominal closure technique. Invariably, a small fraction of patients requiring OA management fail to have primary fascial closure and require some form of biologic fascial bridge with delayed ventral hernia repair in the future.
C1 [Regner, Justin L.; Kobayashi, Leslie; Coimbra, Raul] Univ Calif San Diego, Div Trauma Surg Crit Care & Burns, Dept Surg, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Coimbra, R (通讯作者)，Univ Calif San Diego, Div Trauma Surg Crit Care & Burns, Dept Surg, 200 W Arbor Dr,8896, San Diego, CA 92103 USA.
EM rcoimbra@ucsd.edu
RI Coimbra, Raul/AAP-3019-2020
OI Coimbra, Raul/0000-0002-3759-6851
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NR 108
TC 113
Z9 132
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAR
PY 2012
VL 36
IS 3
BP 497
EP 510
DI 10.1007/s00268-011-1203-7
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 909UX
UT WOS:000301592100002
PM 21847684
OA Bronze
DA 2026-07-24
ER

PT J
AU Pesic, S
   Tulencic-Egic, S
   Zwick, M
AF Pesic, Slobodan
   Tulencic-Egic, Snezana
   Zwick, Mihajlo
TI Above-knee amputation due to necrotizing fasciitis caused by a gas-
   producing strain of Escherichia coli and negative pressure
   therapy assisted closure of a large open wound
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE amputation; surgical; diabetes mellitus; escherichia coli; necrotizing
   fasciitis; wound closure techniques
AB Introduction. Nonclostridial gas-forming soft tissue infec-tions (NGSTI) are rare, rapid progressive infections character-ized by high mortality and high amputation rates. Surgical deb-ridement is crucial in therapy, and it results in complex wounds that need to be closed in order to prevent secondary morbidity. Case report. Herein we present a case of NGSTI in a 68-year-old diabetic patient with acute thrombosis of pop-liteal artery aneurysm and radiological signs of gas in his right leg and the urinary bladder wall. The infection was caused by a gas-forming strain of Escherichia coli. In the early stage of the disease, the patient was treated with antibiotics and femoral amputation. A vacuum-assisted closure (VAC) treatment was applied to close the amputation wound. Administered VAC therapy resulted in primary wound closure without complica-tions 17 days after surgery. Conclusion. Negative pressure in-creases the clearance of fluid and infection from the wound but also increases wound contraction and approximation of skin flaps. To avoid extensive reconstructive surgery, VAC therapy can be a good adjunctive treatment for closing large open wounds in patients with NGSTI.
C1 [Pesic, Slobodan; Tulencic-Egic, Snezana; Zwick, Mihajlo] Gen Hosp Subotica, Dept Surg, Vasc Surg Div, Subotica, Serbia.
   [Pesic, Slobodan] Gen Hosp Subotica, Izvorska 3, Subotica 24000, Serbia.
RP Pesic, S (通讯作者)，Gen Hosp Subotica, Izvorska 3, Subotica 24000, Serbia.
EM spesic90@gmail.com
OI Pešić, Slobodan/0000-0002-3219-1396
CR Aggelidakis J, 2011, WORLD J EMERG SURG, V6, DOI 10.1186/1749-7922-6-28
   Ahn J, 2019, INT J LOW EXTR WOUND, V18, P114, DOI 10.1177/1534734619836464
   Angoules AG, 2007, INJURY, V38, pS19, DOI 10.1016/j.injury.2007.10.030
   Brucato MP, 2014, J FOOT ANKLE SURG, V53, P137, DOI 10.1053/j.jfas.2013.10.009
   de Geus HRH, 2005, INTENS CARE MED, V31, P601, DOI 10.1007/s00134-004-2553-5
   Ghosh S, 2009, J MED MICROBIOL, V58, P965, DOI 10.1099/jmm.0.008821-0
   Huang WS, 2006, ASIAN J SURG, V29, P133
   Itsiopoulos Iraklis, 2020, J Orthop Case Rep, V10, P54, DOI 10.13107/jocr.2020.v10.i04.1800
   Lee JY, 2014, WORLD J EMERG SURG, V9, DOI 10.1186/1749-7922-9-29
   Marinis Athanasios, 2013, Infez Med, V21, P305
   Mikic D, 2000, Vojnosanit Pregl, V57, P339
   Mikic Dragan, 2002, Vojnosanit Pregl, V59, P203, DOI 10.2298/VSP0202203M
   Popov P, 2015, VOJNOSANIT PREGL, V72, P469, DOI 10.2298/VSP1505469P
   Stevens DL, 2017, NEW ENGL J MED, V377, P2253, DOI 10.1056/NEJMra1600673
   Takazawa Kensuke, 2015, Tokai J Exp Clin Med, V40, P124
   Turunç V, 2015, TRANSPL P, V47, P1518, DOI 10.1016/j.transproceed.2015.04.007
   Xue X, 2021, INT WOUND J, V18, P639, DOI 10.1111/iwj.13565
   YANG WH, 1990, J UROLOGY, V143, P960, DOI 10.1016/S0022-5347(17)40151-0
NR 18
TC 0
Z9 0
U1 0
U2 3
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PY 2023
VL 80
IS 6
BP 534
EP 537
DI 10.2298/VSP220315074P
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q0SV1
UT WOS:001054709300001
OA gold
DA 2026-07-24
ER

PT J
AU Fernandez-Alvarez, JA
   Barrera-Pulido, F
   Lagares-Borrego, A
   Narros-Gimenez, R
   Gacto-Sanchez, P
   Gomez-Cia, T
AF Fernandez-Alvarez, Jose-Alberto
   Barrera-Pulido, Fernando
   Lagares-Borrego, Araceli
   Narros-Gimenez, Rocio
   Gacto-Sanchez, Purificacion
   Gomez-Cia, Tomas
TI COVERAGE OF SUPRAUMBILICAL ABDOMINAL WALL DEFECTS: THE
   TUNNELLED-PEDICLED ALT TECHNIQUE
SO MICROSURGERY
LA English
DT Article
ID ANTEROLATERAL THIGH FLAP; VACUUM-ASSISTED CLOSURE; RECONSTRUCTION;
   VERSATILITY; THERAPY; ABDOMEN
AB Abdominal wall defects are a challenge for reconstructive surgeons. Although the utility of anterolateral thigh perforator (ALT) flap has been well established for lower abdominal wall reconstruction, pedicled ALT flap is usually not considered for supraumbilical defects in the most recent algorithms. The purpose of this paper is to report the results of a tunneled pedicled ALT flap for reconstruction of supraumbilical defect from a series of patients. From July 2009 to September2014, six patients underwent delayed abdominal wall coverage using pedicled ALT flaps and reinforcement with polypropylene meshes. Defects occurred after surgical complications and abdominal trauma. Flaps were tunneled beneath the rectus femoris and sartorius muscles to increase the pedicle length. The size of the skin islands ranged from 22-29 X 10-14 cm. All flaps survived and the healing of the wounds was successful. Partial dehiscence of donor site occurred in one patient, and small wound dehiscence due to minimal distal necrosis was observed in another patient. No functional problems were reported in donor site, and no complications occurred in 6-68 months of follow-up. The tunneled pedicled ALT flap may provide a reliable alternative method for abdominal wall reconstruction, including supraumbilical defects. (C) 2015 Wiley Periodicals, Inc.
C1 [Fernandez-Alvarez, Jose-Alberto; Barrera-Pulido, Fernando; Lagares-Borrego, Araceli; Narros-Gimenez, Rocio; Gacto-Sanchez, Purificacion; Gomez-Cia, Tomas] Virgen Del Rocio Univ Hosp, Dept Plast & Reconstruct Surg, Manuel Siurot Av, Seville 41013, Spain.
C3 Virgen del Rocio University Hospital
RP Fernandez-Alvarez, JA (通讯作者)，Virgen Del Rocio Univ Hosp, Dept Plast & Reconstruct Surg, Manuel Siurot Av, Seville 41013, Spain.
EM fdez.alvarezja@gmail.com
CR Althubaiti G, 2014, PLAST RECONSTR SURG, V133, p688E, DOI 10.1097/PRS.0000000000000086
   Bruhin A, 2014, INT J SURG, V12, P1105, DOI 10.1016/j.ijsu.2014.08.396
   Gravvanis AI, 2006, MICROSURG, V26, P432, DOI 10.1002/micr.20267
   Hanasono MM, 2010, PLAST RECONSTR SURG, V125, P209, DOI 10.1097/PRS.0b013e3181c495ed
   Henry CR, 2013, ANN PLAS SURG, V71, P266, DOI 10.1097/SAP.0b013e31828a49f9
   Jang J, 2013, MICROSURG, V33, P482, DOI 10.1002/micr.22117
   Kayano S, 2012, J PLAST RECONSTR AES, V65, P1525, DOI 10.1016/j.bjps.2012.05.003
   Kimata Y, 1999, PLAST RECONSTR SURG, V103, P1191, DOI 10.1097/00006534-199904040-00014
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   Lannon DA, 2011, PLAST RECONSTR SURG, V127, P677, DOI 10.1097/PRS.0b013e3181fed714
   LoGiudice JA, 2014, PLAST RECONSTR SURG, V133, P162, DOI 10.1097/01.prs.0000436838.41936.af
   Mathes SJ, 2000, ANN SURG, V232, P586, DOI 10.1097/00000658-200010000-00014
   Maxhimer JB, 2011, ANN PLAS SURG, V66, P285, DOI 10.1097/SAP.0b013e3181e78711
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Patel KM, 2014, MICROSURG, V34, P233, DOI 10.1002/micr.22205
   RAMIREZ OM, 1990, PLAST RECONSTR SURG, V86, P519, DOI 10.1097/00006534-199009000-00023
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   Sacks Justin M, 2012, Semin Plast Surg, V26, P36, DOI 10.1055/s-0032-1302464
   Scaglioni MF, 2015, MICROSURG, V35, P72, DOI 10.1002/micr.22262
   Wong CH, 2009, PLAST RECONSTR SURG, V124, P500, DOI 10.1097/PRS.0b013e3181addb11
   Zelken JA, 2016, MICROSURG, V36, P104, DOI 10.1002/micr.22354
   Zhou M, 2013, MICROSURG, V33, P620, DOI 10.1002/micr.22178
NR 24
TC 15
Z9 17
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD FEB
PY 2017
VL 37
IS 2
BP 119
EP 127
DI 10.1002/micr.22437
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EP4ED
UT WOS:000397332600005
PM 26109324
DA 2026-07-24
ER

PT J
AU Gäddnäs, F
   Saarnio, J
   Ala-Kokko, T
   Laurila, J
   Koivukangas, V
AF Gaddnas, F.
   Saarnio, J.
   Ala-Kokko, T.
   Laurila, J.
   Koivukangas, V.
TI Continuous retention suture for the management of open abdomen:: A high
   rate of delayed fascial closure
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE open abdomen; abdominal compartment syndrome; damage control surgery;
   vacuum assisted closure; relaparotomy; laparostomy; surgical infection
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM PACK TECHNIQUE; DAMAGE-CONTROL;
   TEMPORARY CLOSURE; PERITONITIS; RELAPAROTOMY; EXPERIENCE; MORTALITY;
   WOUNDS; TRAUMA
AB Background and Aims: Open abdomen is most often a consequence of damage control surgery, abdominal decompression or intra-abdominal infections. Ventral hernia after unsuccessful closure of open abdomen causes marked disability to the patient. Several methods for delayed fascial closure have been developed. Patients treated with continuous retention suture were evaluated to find out how often fascial closure was achieved, and what complications were related to the technique.
   Method: A retrospective analysis of 16 open abdomen patients treated with continuous retention suture.
   Results: The most common cause of open abdomen was abdominal infection. Complete fascial closure was achieved in nine of the eleven surviving patients. Closure failed in one patient. Partial closure was also achieved in one patient. The median time between leaving the abdomen open and starting the process of closure was twelve days. The longest period of open abdomen before successful fascial closure was 29 days. Five patients died before the process of closure was complete.
   Conclusion: Delayed fascial closure can be accomplished by using the retention suture method described here.
C1 [Gaddnas, F.; Koivukangas, V.] Oulu Univ Hosp, Dept Surg, FIN-90029 Oulu, Finland.
   [Gaddnas, F.; Ala-Kokko, T.; Laurila, J.] Oulu Univ Hosp, Dept Anesthesiol, Div Intens Care, Oulu, Finland.
C3 University of Oulu; University of Oulu
RP Koivukangas, V (通讯作者)，Oulu Univ Hosp, Dept Surg, PL 21, FIN-90029 Oulu, Finland.
EM vesa.koivukangas@oulu.fi
OI Gäddnäs, Fiia/0000-0002-9825-5014
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   BENDER JS, 1994, J TRAUMA, V36, P182, DOI 10.1097/00005373-199402000-00005
   BROCK WB, 1995, AM SURGEON, V61, P30
   Cheatham ML, 2004, J TRAUMA, V56, P237, DOI 10.1097/01.TA.0000109858.55483.86
   Cipolla J, 2005, AM SURGEON, V71, P202
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   Howdieshell TR, 2004, AM J SURG, V188, P301, DOI 10.1016/j.amjsurg.2004.03.007
   Koniaris LG, 2001, ARCH SURG-CHICAGO, V136, P1359, DOI 10.1001/archsurg.136.12.1359
   Koperna T, 2000, WORLD J SURG, V24, P32, DOI 10.1007/s002689910007
   Lamme B, 2004, BJS-BRIT J SURG, V91, P1046, DOI 10.1002/bjs.4517
   Losanoff JE, 2002, J AM COLL SURGEONS, V195, P105, DOI 10.1016/S1072-7515(02)01149-3
   Loveland JA, 2004, BRIT J SURG, V91, P1095, DOI 10.1002/bjs.4641
   Miller PR, 2004, ANN SURG, V239, P608, DOI 10.1097/01.sla.0000124291.09032.bf
   Miller RS, 2005, J TRAUMA, V59, P1365, DOI 10.1097/01.ta.0000196004.49422.af
   Moore AFK, 2004, BJS-BRIT J SURG, V91, P1102, DOI 10.1002/bjs.4703
   Mulier S, 2003, WORLD J SURG, V27, P379, DOI 10.1007/s00268-002-6705-x
   Navsaria PH, 2003, BRIT J SURG, V90, P718, DOI 10.1002/bjs.4101
   Orlando R, 2004, ARCH SURG-CHICAGO, V139, P415, DOI 10.1001/archsurg.139.4.415
   SCHEIN M, 1991, WORLD J SURG, V15, P537, DOI 10.1007/BF01675658
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   STASSEN N, 2002, J SURG, V91, P104
   Stone PA, 2004, J TRAUMA, V57, P1082, DOI 10.1097/01.TA.0000149248.02598.9E
   Sugrue M, 2004, INJURY, V35, P642, DOI 10.1016/j.injury.2004.03.011
NR 23
TC 18
Z9 19
U1 0
U2 1
PU FINNISH SURGICAL SOC
PI HELSINKI
PA MAKELANKATU 2 C, PO BOX 49, SF-00501 HELSINKI, FINLAND
SN 1457-4969
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2007
VL 96
IS 4
BP 301
EP 307
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 243VM
UT WOS:000251825400008
PM 18265858
DA 2026-07-24
ER

PT J
AU Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
AF Isago, T
   Nozaki, M
   Kikuchi, Y
   Honda, T
   Nakazawa, H
TI Skin graft fixation with negative-pressure dressings
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative pressure dressings; tie-over bolster dressing; skin graft; skin
   graft fixation
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL
AB The tie-over bolster dressing is the most commonly used method for securing skin grafts. However, it requires surgical skill and experience to make a skin graft adhere closely to a grafting site when the site has a complicatedly curved surface. The lack of appropriate tension and pressure on the skin graft may produce hematoma, dislocation, or wrinkles in the graft. The grafting site for the dorsum of a hand is particularly complicated and irregular and requires delicate changes in pressure when the tie-over bolster dressing is used for sites supported and not supported by bones. We have obtained a high survival rate at such difficult sites by managing skin grafts with negative-pressure dressings. This paper describes the details of the technique with case reports. We have used this technique for skin graft fixation in 10 patients and confirmed its high utility as evidenced by a survival rate of 95% or higher of the grafted areas. Unlike existing techniques that apply pressure on skin grafts, this technique applies a negative pressure to the space between the skin graft and the grafting site to remove hematomas and pull the whole skin graft onto the grafting site with uniform force for adhesion.
C1 Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan.
   Natl Disaster Med Ctr, Dept Plast & Reconstruct Surg, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Isago, T (通讯作者)，Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   FLOWERS RS, 1970, SURG CLIN N AM, V50, P439
   GREELEY PW, 1952, PLAST RECONSTR SURG, V9, P64
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   NAKAYAMA Y, 1990, PLAST RECONSTR SURG, V86, P1216, DOI 10.1097/00006534-199012000-00031
   Sakurai A., 1984, J JPN SOC PLAST RECO, V4, P917
   SAWADA Y, 1990, BURNS, V16, P353, DOI 10.1016/0305-4179(90)90008-K
   SHEEHAN JE, 1946, PLAST RECONSTR SURG, V1, P317, DOI 10.1097/00006534-194611000-00009
   SMITH F, 1926, SURG GYNECOL OBSTET, V42, P556
NR 10
TC 28
Z9 31
U1 0
U2 6
PU JAPANESE DERMATOLGICAL ASSOC
PI TOKYO
PA TAISEI-BLDG., 14-10 HONGO 3-CHOME, BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 0385-2407
J9 J DERMATOL
JI J. Dermatol.
PD SEP
PY 2003
VL 30
IS 9
BP 673
EP 678
DI 10.1111/j.1346-8138.2003.tb00456.x
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 725WB
UT WOS:000185564400006
PM 14578557
DA 2026-07-24
ER

PT J
AU Hofmann, HS
   Ried, M
   Sziklavari, Z
AF Hofmann, Hans-Stefan
   Ried, Michael
   Sziklavari, Zsolt
TI Minimally invasive epicardial left ventricular lead placement in a case
   of massive pleural adhesion
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Wound retractor; Left ventricular (LV) lead implantation; Video-assisted
   thoracoscopic surgery; Cardiac resynchronisation therapy
ID VACUUM-ASSISTED CLOSURE; IMPLANTATION; EMPYEMA
AB Background: In cases of intravenous placement failure of the left ventricular (LV) lead for cardiac resynchronisation therapy (CRT) and obliteration of the left pleural space, the alternative approach of transthoracic placement by video-assisted thoracoscopic surgery (VATS) is difficult and not commonly practiced.
   Methods: Here, we present a simple technique for transthoracic introduction of an epicardial LV lead using a wound retractor (ALEXIS (R)) in a patient with heart failure. This wound retractor enables atraumatic tissue retraction without rib spreading, an optimal direct view in the pleural space for surgical pleurolysis and a high degree of safety for the patient.
   Results: No perioperative complications occurred. The tube drainage was removed on the second postoperative day, and the patient was discharged on the third postoperative day.
   Conclusions: The decided advantage of this new method is the lack of any need for rib spreading using a mechanical retractor. Especially in patients with a history of open-heart surgery (including internal mammary artery bypass grafting and/or revascularisation of the left lateral wall) or known pleural adhesions (e.g., pleuritis or lung operations), the described technique provides a rapid and save access with minimal surgical effort and greater safety.
C1 [Hofmann, Hans-Stefan; Sziklavari, Zsolt] Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, D-93049 Regensburg, Germany.
   [Ried, Michael] Univ Regensburg, Dept Thorac Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Sziklavari, Z (通讯作者)，Hosp Barmherzige Bruder Regensburg, Dept Thorac Surg, Prufeningerstr 86, D-93049 Regensburg, Germany.
EM zsolt.sziklavari@barmherzige-regensburg.de
RI Ried, Michael/AAC-4518-2022; Sziklavari, Zsolt/AGI-2440-2022
OI Ried, Michael/0000-0002-2365-4803; 
CR Gabor S, 2005, EUR J CARDIO-THORAC, V28, P797, DOI 10.1016/j.ejcts.2005.08.026
   Hofmann HS, 2012, ANN THORAC SURG, V93, P1741, DOI 10.1016/j.athoracsur.2011.12.039
   Jaroszewski DE, 2009, ANN THORAC SURG, V88, P112, DOI 10.1016/j.athoracsur.2009.04.006
   Sziklavari Z, 2013, INTERACT CARDIOV TH, V17, P49, DOI 10.1093/icvts/ivt093
NR 4
TC 1
Z9 1
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD APR 10
PY 2014
VL 9
AR 70
DI 10.1186/1749-8090-9-70
PG 3
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AG8XA
UT WOS:000335700400001
PM 24721196
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pauchot, J
   Elkhyat, A
   Rolin, G
   Mac, S
   Grumblat, A
   Fotso, A
   Humbert, P
   Tropet, Y
AF Pauchot, Julien
   Elkhyat, Ahmed
   Rolin, Gwenael
   Mac, Sophie
   Grumblat, Anne
   Fotso, Arnaud
   Humbert, Philippe
   Tropet, Yves
TI Dermal Equivalents in Oncology: Benefit of One-Stage Procedure
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID ARTIFICIAL DERMIS; RECONSTRUCTIVE SURGERY; SUBATMOSPHERIC PRESSURE;
   REGENERATION TEMPLATE; CLINICAL-TRIAL; INTEGRA; SKIN; DEFECTS; BURNS;
   MATRIDERM(R)
AB Background In oncology, dermal equivalent may be indicated to cover losses of substance related to skin tumors or after the removal of skin flaps. Objective To report our experience of two dermal equivalents, Matriderm 1 mm with a one-stage graft (DE1) and Integra DL with a two-stage graft (DE2) in oncology. Patients and Method Retrospective, single-center study involving 16 patients. Results Sixteen patients received dermal equivalents as an alternative to flaps (7 cases), over tendinous areas (7 cases), and for cosmetic purposes (2 cases). Twelve patients received DE1 and four DE2. Wound healing times with DE1 were 4 weeks less than those with DE2. Three cases of infection were noted with DE2. The use of dermal equivalents as an alternative to skin flaps was effective, and no adhesions were found over the tendinous areas. Conclusion The learning curve, the two-stage graft required with DE2, and not using a vacuum-assisted closure system can explain the high infection rate. The use of dermal equivalents is particularly indicated in the treatment of skin defect in oncology. The possibility of a one-stage graft with DE1 and combination with negative pressure therapy is beneficial.
C1 [Pauchot, Julien; Tropet, Yves] Univ Hosp Besancon, Orthopaed Traumatol Plast Reconstruct & Hand Surg, F-25030 Besancon, France.
   [Pauchot, Julien] Univ Franche Comte, Res Unit EA IFR INSERM 4268 I4S 133, F-25030 Besancon, France.
   [Elkhyat, Ahmed; Humbert, Philippe] Univ Hosp Besancon, Dept Dermatol, F-25030 Besancon, France.
   [Elkhyat, Ahmed; Rolin, Gwenael; Humbert, Philippe] Univ Hosp Besancon, Res Unit IBC, F-25030 Besancon, France.
   [Rolin, Gwenael] Univ Hosp Besancon, Clin Invest Ctr Besancon, F-25030 Besancon, France.
   [Mac, Sophie] Univ Hosp Besancon, Skinexigence SAS, F-25030 Besancon, France.
   [Grumblat, Anne] Univ Hosp Besancon, CAMSP, F-25030 Besancon, France.
   [Fotso, Arnaud] Univ Hosp Besancon, Dept Pediat Surg, F-25030 Besancon, France.
C3 Universite Marie et Louis Pasteur; CHU Besancon; Universite Marie et
   Louis Pasteur; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Marie et Louis Pasteur; CHU Besancon; Universite
   Marie et Louis Pasteur; CHU Besancon; Universite Marie et Louis Pasteur;
   CHU Besancon; Universite Marie et Louis Pasteur; CHU Besancon;
   Universite Marie et Louis Pasteur; CHU Besancon; Universite Marie et
   Louis Pasteur; CHU Besancon
RP Pauchot, J (通讯作者)，Univ Hosp Besancon, Orthopaed Traumatol Plast Reconstruct & Hand Surg, Pl St Jacques, F-25030 Besancon, France.
EM jpauchot@chu-besancon.fr
RI ROLIN, Gwenaël/ABE-1820-2021
OI ROLIN, Gwenaël/0000-0002-6234-869X
CR Aquilina D, 2009, J Plast Reconstr Aesthet Surg, V62, pe200, DOI 10.1016/j.bjps.2009.01.089
   Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   Cervelli V, 2011, INT WOUND J, V8, P400, DOI 10.1111/j.1742-481X.2011.00806.x
   Chalmers RL, 2010, J PLAST RECONSTR AES, V63, P2081, DOI 10.1016/j.bjps.2010.02.025
   Corradino B, 2010, J PLAST RECONSTR AES, V63, pE245, DOI 10.1016/j.bjps.2009.05.038
   Dantzer E, 2001, Ann Chir Plast Esthet, V46, P173, DOI 10.1016/S0294-1260(01)00019-X
   Dantzer E, 2001, BRIT J PLAST SURG, V54, P659, DOI 10.1054/bjps.2001.3684
   Haertsch P, 2002, BRIT J PLAST SURG, V55, P362, DOI 10.1054/bjps.2002.3845
   HEIMBACH D, 1988, ANN SURG, V208, P313, DOI 10.1097/00000658-198809000-00008
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   Khan MAA, 2010, J CRANIOFAC SURG, V21, P905, DOI 10.1097/SCS.0b013e3181d8418e
   Lakhel-Le Coadou A, 2000, INDICATIONS SUBSTITU, P1
   Molnar JA, 2004, PLAST RECONSTR SURG, V113, P1339, DOI 10.1097/01.PRS.0000112746.67050.68
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   Nguyen DQA, 2010, BURNS, V36, P23, DOI 10.1016/j.burns.2009.07.011
   Park CA, 2009, ANN PLAS SURG, V62, P164, DOI 10.1097/SAP.0b013e31817d87cb
   Ryan CM, 2002, J BURN CARE REHABIL, V23, P311, DOI 10.1097/00004630-200209000-00002
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NR 23
TC 10
Z9 11
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1076-0512
J9 DERMATOL SURG
JI Dermatol. Surg.
PD JAN
PY 2013
VL 39
IS 1
BP 43
EP 50
DI 10.1111/dsu.12044
PN 1
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 071KJ
UT WOS:000313591100005
PM 23190429
DA 2026-07-24
ER

PT J
AU Yang, Z
   Liu, M
   Zhang, YG
   Guo, X
   Xu, P
AF Yang, Zhi
   Liu, Miao
   Zhang, Yin-gang
   Guo, Xiong
   Xu, Peng
TI Effects of intermittent negative pressure on osteogenesis in human bone
   marrow-derived stroma cells
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Negative pressure; Bone marrow-derived stroma cells (BMSCs);
   Osteogenesis
ID VACUUM-ASSISTED CLOSURE; SHEAR-STRESS; IN-VITRO; ANGIOGENESIS; THERAPY;
   HYPOXIA
AB We investigated the effects of intermittent negative pressure on osteogenesis in human bone marrow-derived stroma cells (BMSCs) in vitro.
   BMSCs were isolated from adult marrow donated by a hip osteoarthritis patient with prosthetic replacement and cultured in vitro. The third passage cells were divided into negative pressure treatment group and control group. The treatment group was induced by negative pressure intermittently (pressure: 50 kPa, 30 min/times, and twice daily). The control was cultured in conventional condition. The osteogenesis of BMSCs was examined by phase-contrast microscopy, the determination of alkaline phosphatase (ALP) activities, and the immunohistochemistry of collagen type I. The mRNA expressions of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) in BMSCs were analyzed by real-time polymerase chain reaction (PCR)
   BMSCs showed a typical appearance of osteoblast after 2 weeks of induction by intermittent negative pressure, the activity of ALP increased significantly, and the expression of collagen type I was positive. In the treatment group, the mRNA expression of OPG increased significantly (P < 0.05) and the mRNA expression of OPGL decreased significantly (P < 0.05) after 2 weeks, compared with the control.
   Intermittent negative pressure could promote osteogenesis in human BMSCs in vitro.
C1 [Yang, Zhi; Liu, Miao; Zhang, Yin-gang] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Orthopaed, Xian 710061, Peoples R China.
   [Guo, Xiong] Xi An Jiao Tong Univ, Inst Environm & Endem Dis, MOE Key Lab Environm & Genes Related Dis, Xian 710061, Peoples R China.
   [Xu, Peng] Xi An Jiao Tong Univ, Sch Mat Sci & Engn, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University
RP Zhang, YG (通讯作者)，Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Orthopaed, Xian 710061, Peoples R China.
EM xgcgfd@126.com
RI Yang, Zhibo/J-1831-2017
OI Xu, Peng/0000-0003-2487-9163
FU Postdoctoral Science Foundation of China [20070421123]
FX Project (No. 20070421123) supported by the Postdoctoral Science
   Foundation of China
CR Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
   Brown JM, 2004, NAT REV CANCER, V4, P437, DOI 10.1038/nrc1367
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NR 21
TC 14
Z9 19
U1 0
U2 10
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD MAR
PY 2009
VL 10
IS 3
BP 188
EP 192
DI 10.1631/jzus.B0820240
PG 5
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA 416AW
UT WOS:000263978600005
PM 19283873
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Celik, M
   Öztürk, V
   Catal, T
   Bayrak, A
   Duramaz, A
   Bilgili, MG
AF Celik, Malik
   Ozturk, Vedat
   Catal, Tevfik
   Bayrak, Alkan
   Duramaz, Altug
   Bilgili, Mustafa Gokhan
TI The efficacy of the Bogota Bag technique for wound closure in limb
   fasciotomy patients: a prospective cohort study
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Acute compartment syndrome; Fasciotomy; Limb fasciotomy; Fasciotomy
   closure; Bogota Bag
ID VACUUM-ASSISTED CLOSURE; COMPARTMENT SYNDROME; DECOMPRESSION; PRESSURE;
   DEVICE; THIGH; LEG
AB PurposeFasciotomy is a surgical procedure that involves the incision of fascial compartments in the body to relieve pressure, prevent tissue damage, and maintain blood flow. This study aimed to investigate the effectiveness of the Bogota Bag technique in closing fasciotomy wounds in patients with lower limb compartment syndrome.MethodsA prospective cohort study was conducted between October 2022 and October 2023 to document our experience in employing the Bogota Bag technique for fasciotomy closure. The study included the evaluation of medical files from fifteen patients aged 17 to 61.ResultsThe outcomes of the study present the initial series of limb fasciotomies treated with the Bogota Bag technique. Fifteen patients (14 male, 1 female) were included in the study. The average age of the patients was 34.73 +/- 13.9 years and the average hospitalization was 8.33 +/- 3.2 days. The average closure time of fasciotomy is 3.6 +/- 1.4 days.ConclusionThis report makes a significant contribution as the first documented series of limb fasciotomies treated with the Bogota Bag technique. This method exhibits simplicity in execution, cost-effectiveness, and a low incidence of complications.
C1 [Celik, Malik; Ozturk, Vedat; Bayrak, Alkan; Duramaz, Altug; Bilgili, Mustafa Gokhan] Bakirkoy Dr Sadi Konuk Res & Training Hosp Orthop, Bakirkoy Dr,Zuhuratbaba Mah Tevfik Saglam Cad 11, TR-34147 Istanbul, Turkiye.
   [Catal, Tevfik] Kahramanmaras Necip Fazil City Hosp, Orthopaed & Traumatol Clin, Kahramanmaras, Turkiye.
C3 Kahramanmaras Necip Fazil City Hospital
RP Celik, M (通讯作者)，Bakirkoy Dr Sadi Konuk Res & Training Hosp Orthop, Bakirkoy Dr,Zuhuratbaba Mah Tevfik Saglam Cad 11, TR-34147 Istanbul, Turkiye.
EM drmalikcelik@hotmail.com; dr.ozturkvedat@gmail.com;
   tevfik.catal@gmail.com; drqueum@gmail.com; altug.duramaz@yahoo.com;
   mgbilgili@yahoo.com
RI duramaz, altuğ/K-2700-2018; Çatal, Tevfik/JGD-5398-2023; Bayrak,
   Alkan/GWC-5172-2022; ÇELIK, Malik/HTP-5021-2023; ozturk,
   vedat/IZQ-0098-2023; duramaz, altuğ/K-2700-2018; /M-2923-2014
OI duramaz, altuğ/0000-0002-5012-2079; Çatal, Tevfik/0000-0001-5151-6478;
   Bayrak, Alkan/0000-0003-0189-1645; , mustafa/0000-0002-5301-6407; ÇELIK,
   Malik/0000-0002-3696-9644; ozturk, vedat/0000-0003-2412-9725; 
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NR 29
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD NOV
PY 2024
VL 48
IS 11
BP 2971
EP 2978
DI 10.1007/s00264-024-06292-4
EA SEP 2024
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA J4N6T
UT WOS:001307568100002
PM 39235618
DA 2026-07-24
ER

PT J
AU Shukla, R
   Karagaiah, P
   Patil, A
   Farnbach, K
   Ortega-Loayza, AG
   Tzellos, T
   Szepietowski, JC
   Giulini, M
   Schepler, H
   Grabbe, S
   Goldust, M
AF Shukla, Ratnakar
   Karagaiah, Priyanka
   Patil, Anant
   Farnbach, Katherine
   Ortega-Loayza, Alex G.
   Tzellos, Thrasivoulos
   Szepietowski, Jacek C.
   Giulini, Mario
   Schepler, Hadrian
   Grabbe, Stephan
   Goldust, Mohamad
TI Surgical Treatment in Hidradenitis Suppurativa
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE hidradenitis suppurativa; apocrine gland; follicular occlusion
ID VACUUM-ASSISTED CLOSURE; DIOXIDE LASER EXCISION; AXILLARY HIDRADENITIS;
   DIVERSE APPLICATION; TREATMENT OPTION; RECURRENCE RATE; MANAGEMENT;
   EXPERIENCE; FLAP; CO2-LASER
AB Hidradenitis suppurativa (HS) is a chronic, progressive inflammatory disorder of follicular occlusion with pubertal onset that presents as painful inflammatory nodules, sinus tracts, and tunnelling in apocrine-gland-rich areas, such as the axilla, groin, lower back, and buttocks. The disease course is complicated by contractures, keloids, and immobility and is often associated with a low quality of life. It is considered a disorder of follicular occlusion with secondary inflammation, though the exact cause is not known. Management can often be unsatisfactory and challenging due to the chronic nature of the disease and its adverse impact on the quality of life. A multidisciplinary approach is key to prompt optimal disease control. The early stages can be managed with medical treatment, but the advanced stages most likely require surgical intervention. Various surgical options are available, depending upon disease severity and patient preference. In this review an evidence-based outline of surgical options for the treatment of HS are discussed. Case reports, case series, cohort studies, case-control studies, and Randomized Clinical Trials (RCT)s available in medical databases regarding surgical options used in the treatment of HS were considered for the review presented in a narrative manner in this article.
C1 [Shukla, Ratnakar] All India Inst Med Sci Gorakhpur AIIMS, Dept Dermatol, Gorakhpur 273008, Uttar Pradesh, India.
   [Karagaiah, Priyanka] Bangalore Med Coll & Res Inst, Dept Dermatol, Bangalore 560002, Karnataka, India.
   [Patil, Anant] Dr DY Patil Med Coll, Dept Pharmacol, Navi Mumbai 400706, India.
   [Farnbach, Katherine; Ortega-Loayza, Alex G.] Oregon Hlth & Sci Univ, Dept Dermatol, Portland, OR 97239 USA.
   [Tzellos, Thrasivoulos] NLSH Univ Hosp, Dept Dermatol, N-8092 Bodo, Norway.
   [Tzellos, Thrasivoulos] European Hidradenitis Suppurat Fdn eV, D-06847 Dessau, Germany.
   [Szepietowski, Jacek C.] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, PL-50367 Wroclaw, Poland.
   [Giulini, Mario; Schepler, Hadrian; Grabbe, Stephan; Goldust, Mohamad] Univ Med Ctr Mainz, Dept Dermatol, D-55131 Mainz, Germany.
C3 Bangalore Medical College & Research Institute (BMCRI); Oregon Health &
   Science University; Wroclaw Medical University; Johannes Gutenberg
   University of Mainz
RP Szepietowski, JC (通讯作者)，Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, PL-50367 Wroclaw, Poland.; Goldust, M (通讯作者)，Univ Med Ctr Mainz, Dept Dermatol, D-55131 Mainz, Germany.
EM ratnakarshukla88@gmail.com; pri20111992@gmail.com;
   anantd1patil@gmail.com; farnbach@ohsu.edu; ortegalo@ohsu.edu;
   ltzellos@googlemail.com; jacek.szepietowski@umed.wroc.pl;
   mario.giulini@unimedizin-mainz.de; hadrian.schepler@unimedizin-mainz.de;
   stephan.grabbe@unimedizin-mainz.de; mgoldust@uni-mainz.de
RI Shukla, Ratnakar/AAK-4901-2021; Grabe, Stephan/AAJ-4578-2021; Loayza,
   Alex/AAN-3319-2020; Patil, Anant/J-4276-2019
OI Tzellos, Thrasivoulos/0000-0003-2356-0847; Szepietowski,
   Jacek/0000-0003-0766-6342; Goldust, Mohamad/0000-0002-8646-1179; Patil,
   Anant/0000-0002-9455-4025
FU Research Grant from Wrocaw Medical University, Poland [SUB.C260.22.056]
FX This study was supported by the Research Grant from Wrocaw Medical
   University, Poland (number: SUB.C260.22.056).
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NR 96
TC 50
Z9 58
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2022
VL 11
IS 9
AR 2311
DI 10.3390/jcm11092311
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1E4WT
UT WOS:000794491500001
PM 35566438
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, XG
   Zhang, YH
   Han, CM
AF Wang, Xingang
   Zhang, Yuanhai
   Han, Chunmao
TI Topical negative pressure improves autograft take by altering nutrient
   diffusion: A hypothesis
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE topical negative pressure; wound healing; autograft
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CLINICAL
   EFFECTIVENESS; BURNS; SKIN; SURGERY; THERAPY; INTEGRA
AB The one-step surgical procedure for dermal substitutes combined with topical negative pressure (TNP) has proven effective for treating deep skin defects with improved graft take. The primary mechanism by which TNP improves autograft take is unknown. Some studies suggest that TNP promotes the rapid angiogenesis of dermal substitutes, improving graft take. However, at the early stage of one-step transplantation, the vascular system has not formed and imbibition is the main mode of nutrient supply. TNP can shorten the diffusion distance from the wound bed to the graft, leading to the timely renewal of the wound exudate via suction, removing any surplus exudate, and reducing tissue edema. In addition, TNP can regulate the local blood flow and inhibit bacterial colonization. Therefore, we hypothesized that TNP establishes a rapid balance between the nutrient supply to the wound bed and nutritional requirement of the graft via these pathways in the relatively closed, moist environment, improving autograft take. However, this balance could be affected by any negative pressure, intermittent or continuous. It is necessary to test this hypothesis in laboratory and clinical studies of the mode of nutrient supply in the imbibition phase and the change in exudate content.
C1 [Wang, Xingang; Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Dept Burns, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wang, Xingang; Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Wound Care Ctr, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zhang, Yuanhai] Quhua Hosp, Dept Burns & Plast Surg, Quzhou, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Wang, XG (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Dept Burns, Hangzhou 310003, Zhejiang, Peoples R China.
EM wxg8157@163.com
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NR 18
TC 8
Z9 9
U1 0
U2 7
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JAN 16
PY 2014
VL 20
BP 61
EP 63
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 291XH
UT WOS:000329865400001
PM 24435118
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Myatt, A
   Saleeb, H
   Robertson, GAJ
   Bourhill, JK
   Page, PRJ
   Wood, AM
AF Myatt, A.
   Saleeb, H.
   Robertson, G. A. J.
   Bourhill, Jana Keren
   Page, P. R. J.
   Wood, A. M.
TI Management of Gustilo-Anderson IIIB open tibial fractures in adults-a
   systematic review
SO BRITISH MEDICAL BULLETIN
LA English
DT Review
DE open tibia fracture; GIIIB open tibia fracture
ID FEMORAL-SHAFT FRACTURES; VACUUM-ASSISTED CLOSURE; SURGICAL DEBRIDEMENT;
   EXTERNAL FIXATOR; DEEP INFECTION; GRADE; ILIZAROV; RECONSTRUCTION;
   METAANALYSIS; IMMEDIATE
AB Introduction: Open tibial fractures are the most common open long bone fracture, despite this, the management of these complex injuries still remains a topic of discussion amongst orthopaedic surgeons.
   Sources of data: We searched the EMBASE, MEDLINE and Google Scholar and a systematic review of 7500 articles, leaving 23 after exclusion criteria were applied, in order to analyse the management of open tibial fractures.
   Areas of agreement and controversy: Infection was noted to be the most significant concern amongst authors, with definitive external fixation having a high rate of superficial pin-site infection and internal fixation having a high deep infection rate.
   Growing points: It is essential to have a combined ortho-plastic approach to the management of these fractures as muscle flaps were the most common form of soft tissue coverage.
   Areas timely for developing research: A national pragmatic trial into the management of open tibial fractures is required looking at fixation methods and soft tissue coverage, with at least a 2-year follow-up in order to ascertain the most appropriate management of these fractures and patient-related outcomes.
C1 [Myatt, A.] ST4 Orthopaed Registrar Leeds Gen Infirm MRCSEd, Dept Trauma & Orthopaed, Great George St, Leeds LS1 3EX, W Yorkshire, England.
   [Saleeb, H.] Orthopaed Registrar Oxford Univ Hosp MRCS, Dept Trauma & Orthopaed, Headley Way, Oxford 0X3 9DU, England.
   [Robertson, G. A. J.] Orthopaed Registrar Royal Infirm Edinburgh FRCSEd, Dept Trauma & Orthopaed, 51 Little France Cres,Old Dalkeith Rd, Edinburgh EH16 4SA, Midlothian, Scotland.
   [Bourhill, Jana Keren] Univ Oxford, John Radcliffe Hosp, Med Sci Div Off, Level 3, Oxford OX3 9DU, England.
   [Page, P. R. J.; Wood, A. M.] John Radcliffe Hosp Oxford, Dept Trauma & Orthopaed, FRCS T&O, Headley Way, Oxford OX3 9DU, England.
C3 University of Oxford
RP Wood, AM (通讯作者)，John Radcliffe Hosp Oxford, FRCSEd T&O, Oxford, England.
EM drsandywood@googlemail.com
OI Bourhill, Jana/0000-0002-0702-1408
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NR 51
TC 10
Z9 18
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1420
EI 1471-8391
J9 BRIT MED BULL
JI Br. Med. Bull.
PD SEP
PY 2021
VL 139
IS 1
BP 48
EP 58
DI 10.1093/bmb/ldab013
EA JUL 2021
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YI2JB
UT WOS:000743679300005
PM 34227647
DA 2026-07-24
ER

PT J
AU Orenstein, A
   Kachel, E
   Zuloff-Shani, A
   Paz, Y
   Sarig, O
   Haik, J
   Smolinsky, AK
   Mohr, R
   Shinar, E
   Danon, D
AF Orenstein, A
   Kachel, E
   Zuloff-Shani, A
   Paz, Y
   Sarig, O
   Haik, J
   Smolinsky, AK
   Mohr, R
   Shinar, E
   Danon, D
TI Treatment of deep sternal wound infections post-open heart surgery by
   application of activated macrophage suspension
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; BYPASS GRAFT-SURGERY;
   RISK-FACTORS; PREVENTABLE COMPLICATION; ANTIMACROPHAGE SERUM;
   HYPOOSMOTIC SHOCK; CARDIAC-SURGERY; MEDIASTINITIS; MANAGEMENT
AB Postoperative sternal wound infection remains a significant complication and generally causes considerable morbidity and mortality. Macrophages play a major role in the process of wound healing. In order to evaluate the efficacy of local injection of activated macrophage suspensions into open infected sternal wound space, a retrospective case-control study was conducted. Sixty-six patients with deep sternal wound infection treated by activated macrophages (group 1) and 64 patients with deep sternal wound infection treated by sternal reconstruction surgery with various regional flaps (group 2), were matched for gender, age, and risk index. In up to 54 months of follow-up of group 1, 60 patients (91%) achieved complete wound closure. Two (3%) late deaths occurred unrelated to the procedure. Mortality rate in group 2 was 29.7% (19/64). Duration of hospitalization was 22.6 days in group 1 vs. 56.2 days in group 2. Patients with deep sternal wound infection following open heart surgery that were treated by activated macrophages had significantly less mortality as well as significant reduction of hospitalization in comparison to the surgically treated group. These results illustrate the advantages of using a biologically based activated macrophage treatment.
C1 Magen David Adom Israel, Blood Serv Ctr, Res & Dev Unit, IL-52621 Ramat Gan, Israel.
   Chaim Sheba Med Ctr, Dept Plast Surg, Ramat Gan, Israel.
   Chaim Sheba Med Ctr, Dept Cardiac & Thorac Surg, Ramat Gan, Israel.
   Sourasky Med Ctr, Dept Thorac & Cardiovasc Surg, Tel Aviv, Israel.
C3 Chaim Sheba Medical Center; Tel Aviv University; Tel Aviv University;
   Chaim Sheba Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center
RP Danon, D (通讯作者)，Magen David Adom Israel, Blood Serv Ctr, Res & Dev Unit, IL-52621 Ramat Gan, Israel.
EM dan-d@zahav.net.il
OI Haik, Josef/0000-0003-2939-0324
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NR 53
TC 26
Z9 35
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2005
VL 13
IS 3
BP 237
EP 242
DI 10.1111/j.1067-1927.2005.130304.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 931NI
UT WOS:000229491600004
PM 15953041
DA 2026-07-24
ER

PT J
AU Blackburn, JH
   Boemi, L
   Hall, WW
   Jeffords, K
   Hauck, RM
   Banducci, DR
   Graham, WP
AF Blackburn, JH
   Boemi, L
   Hall, WW
   Jeffords, K
   Hauck, RM
   Banducci, DR
   Graham, WP
TI Negative-pressure dressings as a bolster for skin grafts
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
AB Contoured wounds needing closure with skin grafts are often located in complex anatomic regions or are in unusual positions, which make conventional skin graft stabilization techniques cumbersome and ineffective. Often after 72 hours, a skin graft covered with a bolstered dressing has poor take secondary to shear stresses, as well as hematoma formation or serum collection, negating the effectiveness of the stabilizing dressing. The Food and Drug Administration has recently approved vacuum-assisted closure (V.A.C.), an innovative technique using negative pressure, for closure of chronic wounds. This reportedly leads to enhanced granulation tissue formation and consequently more rapid reepithelialization of wounds compared with conventional packing with saline-moistened gauze. Experimental studies have demonstrated increased oxygen tension, decreased bacterial counts, and increased granulation formation occurring under negative-pressure systems. Extending the use of this concept, we have coupled skin grafting with negative-pressure dressings for closure of large, complex open wounds. Our results indicate greater than 95% graft take in all patients in this study, This technique is extremely efficacious, with increased graft take due to total immobilization of the graft, thereby limiting shear forces, elimination of fluid collections, bridging of the graft, and decreased bacterial contamination. Moreover we have noted decreased edema in rotated muscle flaps, improved contour conformity, and shortened hospitalizations.
C1 Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst, Plast & Reconstruct Surg Sect,Dept Surg, Hershey, PA 17033 USA.
C3 Geisinger Health System; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Penn State Health
RP Blackburn, JH (通讯作者)，Penn State Univ, Milton S Hershey Med Ctr, Penn State Geisinger Hlth Syst, Plast & Reconstruct Surg Sect,Dept Surg, POB 850,MC H071, Hershey, PA 17033 USA.
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NR 15
TC 214
Z9 885
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 1998
VL 40
IS 5
BP 453
EP 457
DI 10.1097/00000637-199805000-00001
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ZL507
UT WOS:000073440400001
PM 9600426
DA 2026-07-24
ER

PT J
AU Altman, AD
   Robinson, C
AF Altman, Alon D.
   Robinson, Christine
TI Vulvar postoperative care, gestalt or evidence based medicine? A
   comprehensive systematic review
SO GYNECOLOGIC ONCOLOGY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; LYMPH-NODE DISSECTION; PROSPECTIVE
   RANDOMIZED-TRIAL; MODIFIED RADICAL VULVECTOMY; INGUINAL LYMPHADENECTOMY;
   GROIN DISSECTION; GYNECOLOGIC-ONCOLOGY; WOUND COMPLICATIONS; ABDOMINAL
   OPERATIONS; SURGICAL-TREATMENT
AB Objective. This paper reviews all current literature for vulvar postoperative care, and forms a summary of evidence based practice.
   Data sources. Scopus, Cochrane Library, CINHAL, Web of Science Core Collection, PubMed, Embase, Google Scholar, clinicaltrials.gov and Medline databases were searched.
   Methods of study selection. Various combinations of key-terms were used to identify relevant articles. All identified primary research articles and review articles were then examined with their references in order to identify further relevant studies. The literature was examined within gynecology, gynecologic oncology, surgical oncology, urology, plastic surgery and dermatology.
   Tabulation, integration and results. A total of 199 studies were reviewed and 80 were included in this paper. All relevant studies pertaining to the subject were included. Studies were excluded if there was no relevance to the review as deemed by both authors.
   Conclusion. There remains much room for improvement to minimize postoperative stay, decrease the chances of morbidity and improve patient outcome and satisfaction, while establishing standardized care pathways. Further research and clinical trials are needed in this area to help us to provide evidence-based care to our postoperative vulvar patient population. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Altman, Alon D.; Robinson, Christine] Univ Manitoba, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Winnipeg, MB, Canada.
C3 University of Manitoba
RP Altman, AD (通讯作者)，Univ Manitoba, RS 406,810 Sherbrook St, Winnipeg, MB R3A 1R9, Canada.
EM alon.altman@cancercare.mb.ca
OI Altman, Alon/0000-0002-6345-4910
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NR 71
TC 3
Z9 5
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
EI 1095-6859
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAY
PY 2017
VL 145
IS 2
BP 386
EP 392
DI 10.1016/j.ygyno.2017.02.013
PG 7
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA EU3TR
UT WOS:000400954400026
PM 28202196
DA 2026-07-24
ER

PT J
AU Fujii, T
   Watanabe, Y
AF Fujii, Takeshiro
   Watanabe, Yoshinori
TI Multidisciplinary Treatment Approach for Prosthetic Vascular Graft
   Infection in the Thoracic Aortic Area
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Review
DE thoracic aorta; prosthetic vascular graft infection; multidisciplinary
   treatment
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; LOADED
   POLYMETHYLMETHACRYLATE BEADS; SURGICAL SITE INFECTIONS;
   STAPHYLOCOCCUS-AUREUS; POSTSTERNOTOMY MEDIASTINITIS; ANTIMICROBIAL
   STEWARDSHIP; INTERCELLULAR-ADHESION; ANTIBIOTIC RETENTION; PROPHYLACTIC
   AGENTS
AB Prosthetic vascular graft infection in the thoracic aortic area is a rare but serious complication. Adequate management of the complication is essential to increase the chance of success of open surgery. While surgical site infection is suggested as the root cause of the complication, it is also related to decreased host tolerance, especially as found in elderly patients. The handling of prosthetic vascular graft infection has been widely discussed to date. This paper mainly provides a summary of literature reports published within the past 5 years to discuss issues related to multidisciplinary treatment approaches, including surgical site infection, timing of onset, diagnostic methods, causative pathogens, auxiliary diagnostic methods, antibiotic treatment, anti-infective structures of vascular prostheses, surgical treatment, treatment strategy against infectious aortic aneurysms, future surgical treatment, postoperative systemic therapy, and antimicrobial stewardship. A thorough understanding of these issues will enable us to prevent prosthetic vascular graft infection in the thoracic aortic area as far as possible. In the event of its occurrence, the early introduction of appropriate treatment is expected to cure the disease without worsening of the underlying pathological condition.
C1 [Fujii, Takeshiro; Watanabe, Yoshinori] Toho Univ, Fac Med, Sch Med, Div Cardiovasc Surg,Dept Surg,Ota Ku, Tokyo 1438541, Japan.
RP Fujii, T (通讯作者)，Toho Univ, Fac Med, Sch Med, Div Cardiovasc Surg,Dept Surg,Ota Ku, 6-11-1 Omorinishi, Tokyo 1438541, Japan.
EM fujiit@med.toho-u.ac.jp
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NR 83
TC 19
Z9 24
U1 0
U2 2
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2015
VL 21
IS 5
BP 418
EP 427
DI 10.5761/atcs.ra.15-00187
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA CU8KV
UT WOS:000363792200002
PM 26356686
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Feisthammel, J
   Jonas, S
   Mössner, J
   Hoffmeister, A
AF Feisthammel, J.
   Jonas, S.
   Moessner, J.
   Hoffmeister, A.
TI The Role of Endoscopy in the Therapy for Perforations and Leakages of
   the Gastrointestinal Tract
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Review
DE GI tract; interventional endoscopy; complication; perforation
ID ERCP-RELATED PERFORATIONS; VACUUM-ASSISTED CLOSURE;
   ESOPHAGEAL-PERFORATION; LAPAROSCOPIC CHOLECYSTECTOMY; BILIARY
   COMPLICATIONS; SURGICAL-MANAGEMENT; ANASTOMOTIC LEAKAGE; RISK-FACTORS;
   STENTS; EXPERIENCE
AB Perforations and leakages of hollow organs of the gastrointestinal tract can occur spontaneously among other causes. They can also develop as complications of an endoscopic intervention or after surgical construction of an anastomosis. For the patient, these situations usually are serious and life-threatening. Standard therapy has always been - and most of the time still is - major surgery. These procedures usually are technically difficult and their mortality and morbidity are not satisfactory due to, among others, the occurrence of local infections. Thus, various endoscopic techniques as therapy for perforations and leakages have been developed over the last years. These include above all the endoscopic placement of clip systems and stents and the relatively new vacuum drainage systems. In case of perforations and leakages of the bile duct and the rectum especially, these minimal invasive techniques are widely used, also increasingly in lesions of the esophagus. However, these new, endoscopic procedures suffer from a lack of evidence. This paper highlights the possibilities and limitations of endoscopic options in therapy for perforations and leakages of organs of the gastrointestinal tract.
C1 [Feisthammel, J.; Moessner, J.; Hoffmeister, A.] Univ Klinikum Leipzig, Dept Innere Med Neurol & Dermatol, Klin Gastroenterol & Rheumatol, D-04103 Leipzig, Germany.
   [Jonas, S.] Univ Klinikum Leipzig, Dept Operat Med, Klin & Poliklin Viszeral Transplantat Thorax & Ge, D-04103 Leipzig, Germany.
C3 Leipzig University; Leipzig University
RP Feisthammel, J (通讯作者)，Univ Klinikum Leipzig, Dept Innere Med Neurol & Dermatol, Klin Gastroenterol & Rheumatol, Liebigstr 20, D-04103 Leipzig, Germany.
EM juergen.feisthammel@medizin.uni-leipzig.de
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NR 37
TC 5
Z9 5
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD JUN
PY 2013
VL 138
IS 3
BP 295
EP 300
DI 10.1055/s-0031-1283960
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 190XT
UT WOS:000322377500035
PM 22562158
DA 2026-07-24
ER

PT J
AU Sraj, S
   Henderson, JT
   Bramer, M
   Gelman, J
AF Sraj, Shafic
   Henderson, Joshua T.
   Bramer, Michelle
   Gelman, Jack
TI Principles of Fasciotomy Closure After Compartment Syndrome Release
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID DELAYED PRIMARY CLOSURE; TIBIAL PLATEAU FRACTURES; VACUUM-ASSISTED
   CLOSURE; WOUND CLOSURE; LEG; DERMATOTRACTION; INFECTION; DEVICE; TRAUMA
AB Acute compartment syndrome is a surgical emergency in the extremities resulting from increased compartmental pressure, requiring immediate fasciotomy to resolve muscular compromise. As the mainstay treatment, fasciotomies involve substantial skin incisions and are thus prone to complications such as skin necrosis, wound infection, and permanent disability. Multidisciplinary care instituted at the time of fasciotomy can facilitate timely closure and minimize the complication profile. Several approaches are available to enhance outcomes of fasciotomy wounds, and a comprehensive knowledge of these options affords the treating surgeon greater flexibility and confidence in optimal management. Common techniques include early primary closure, gradual approximation, skin grafting, and negative pressure therapy. There is currently no consensus on the best method of closure. The purpose of this study was to review fasciotomy wound management from the time of initial release to final closure. Highlights include preparation for closing these wounds; the various techniques for fasciotomy closure, including adjunct options; evaluation of timing and staging; and injury-specific features, such as fracture management, limited subcutaneous tissues, and hand fasciotomies. Combining the perspectives of orthopaedic and plastic surgery, this review evaluates the benefits of multiple closure methods and highlights the importance of planning closure at the time of release.
C1 [Sraj, Shafic; Bramer, Michelle] West Virginia Univ, Dept Orthopaed, Morgantown, WV 26506 USA.
   [Henderson, Joshua T.; Gelman, Jack] West Virginia Univ, Dept Surg, Div Plast Surg, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Sraj, S (通讯作者)，West Virginia Univ, Dept Orthopaed, Morgantown, WV 26506 USA.
RI Henderson, Joshua/ABD-2229-2021; Sraj, Shafic/CAH-2822-2022
OI Sraj, Shafic/0000-0003-3873-7369
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NR 44
TC 13
Z9 15
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD SEP 15
PY 2022
VL 30
IS 18
BP 879
EP 887
DI 10.5435/JAAOS-D-21-01046
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 4M2MG
UT WOS:000853160300002
PM 36001887
DA 2026-07-24
ER

PT J
AU Nikolaidis, N
   Karangelis, D
   Mattam, K
   Tsang, G
   Ohri, S
AF Nikolaidis, Nicolas
   Karangelis, Dimos
   Mattam, Kavitha
   Tsang, Geoffrey
   Ohri, Sunil
TI The Use of Nitinol Clips for Primary Sternal Closure in Cardiac Surgery
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE wound closure; mediastinal infection; wound infection; wound dehiscence;
   sternum
ID VACUUM-ASSISTED CLOSURE; THERMOREACTIVE CLIPS; INFECTIONS
AB Purpose: Deep sternal wound complications after cardiac surgery have an incidence of 2 to 8% and carry a significant mortality. The aim of this study was to evaluate the effect of thermo-reactive Nitinol clips on the incidence of postoperative deep sternal wound complications.
   Methods: We retrospectively reviewed 1119 consecutive patients that underwent major cardiac surgery via median sternotomy in our centre. Sternal closure was performed using Nitinol clips in 235 patients (Group I) and standard stainless steel wires in 884 patients (Group II). The risk factors that were identified between the two groups were age, EuroSCORE, body mass index, diabetes and pulmonary comorbidity.
   Results: The overall incidence of deep sternal wound complications was 2.2% (25/1119). The incidence was higher in Group II (2.3%) compared to Group I (1.7%) (p = 0.8). Mechanical sternal dehiscence occurred in 2 patients in Group II. Mortality related to sternal wound complications was 8% (2/21) in Group II whereas in Group I was 0%.
   Conclusion: The incidence of sternal wound complications and the mortality related to them were lower in patients undergoing sternal closure with Nitinol clips. A randomized study to further evaluate the possible advantages of Nitinol clips is warranted.
C1 [Nikolaidis, Nicolas; Karangelis, Dimos; Mattam, Kavitha; Tsang, Geoffrey; Ohri, Sunil] Southampton Univ Hosp, Wessex Cardiac Ctr, Southampton SO16 5LJ, Hants, England.
C3 University of Southampton
RP Karangelis, D (通讯作者)，Southampton Univ Hosp, Wessex Cardiac Ctr, 16 Trecox Pl,250 Coxford Rd, Southampton SO16 5LJ, Hants, England.
EM dimoskaragel@yahoo.gr
OI Karangelis, Dimos/0000-0001-7633-9949
CR Centofanti P, 2002, ANN THORAC SURG, V74, P943, DOI 10.1016/S0003-4975(02)03674-3
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
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   Losanoff JE, 2004, ANN THORAC SURG, V77, P203, DOI 10.1016/S0003-4975(03)01468-1
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   Vohra HA, 2010, J THORAC CARDIOV SUR, V139, P497, DOI 10.1016/j.jtcvs.2008.12.003
NR 10
TC 6
Z9 9
U1 0
U2 4
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PD AUG
PY 2013
VL 19
IS 4
BP 330
EP 334
DI 10.5761/atcs.nm.12.01947
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 217KN
UT WOS:000324358500017
PM 23237926
OA gold
DA 2026-07-24
ER

PT J
AU Basile, A
   Stopponi, M
   Loreti, A
   de Simeonibus, AUM
AF Basile, Attilio
   Stopponi, Marcello
   Loreti, Andrea
   de Simeonibus, Angelo Ugo Minniti
TI Heel coverage using a distally based sural artery fasciocutaneous
   cross-leg flap: Report of a small series
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE calcaneus; cross-leg flap; degloving; fasciocutaneous flap; heel ulcer;
   musculoskeletal trauma; soft tissue defect
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; THERAPY
AB One of the goals in the management of severe open injuries of the foot is to obtain adequate soft tissue coverage. In extreme conditions of pedal soft tissue loss, in patients who are not satisfactory candidates for local or free-tissue transfer, the cross-leg flap remains an option for surgical reconstruction. We present the results of 7 patients with multiple lower limb open fractures associated with ipsilateral degloving injuries, and/or secondary pressure ulcers of the hindfoot with exposure of the calcaneus, in which a distally based sural artery island fasciocutaneous flap, elevated from the contralateral leg and crossed to the injured side, was used to repair the soft tissue defect of the recipient heel. All of the flaps survived and the soft tissues healed uneventfully, thereby providing satisfactory and stable coverage of the calcaneal tuberosity. To the best of our knowledge, this is the first report in which this technique has been used to repair hindfoot soft tissue defects associated with complex bone and vascular injuries of the lower limb in polytrauma patients. Level of Clinical Evidence: 4.
C1 [Basile, Attilio; Stopponi, Marcello; de Simeonibus, Angelo Ugo Minniti] Osped San Giovanni Addolorata, Dept Orthopaed & Trauma Surg, Rome, Italy.
   [Loreti, Andrea] Osped San Giovanni Addolorata, Dept Plast & Reconstruct Surg, Rome, Italy.
RP Basile, A (通讯作者)，Via Nicola Pellati 45, I-00149 Rome, Italy.
EM attbasile@tiscali.it
RI Loreti, Anea/JCP-4625-2023
OI Loreti, Anea/0009-0000-7378-8431
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NR 21
TC 23
Z9 29
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2008
VL 47
IS 2
BP 112
EP 117
DI 10.1053/j.jfas.2007.12.005
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 340RV
UT WOS:000258663600006
PM 18312918
DA 2026-07-24
ER

PT J
AU Mouës, CM
   Heule, F
   Legerstee, R
   Hovius, SER
AF Moues, Chantal M.
   Heule, Freerk
   Legerstee, Ron
   Hovius, Steven E. R.
TI Five Millennia of Wound Care Products - What is New? A Literature Review
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE historical review; wound care; topical management; evidence
ID VACUUM-ASSISTED CLOSURE; GROWTH FACTOR-BB; HYPERBARIC-OXYGEN;
   ANTIBACTERIAL ACTIVITY; HYDROGEN-PEROXIDE; SEALING-TECHNIQUE;
   GENE-TRANSFER; SKIN; THERAPY; HONEY
AB The first wound and wound treatments were described five millennia ago. Since then, various principles of wound care have been passed on from generation to generation. In contrast to large numbers of general technological inventions over the last 100 years, progress beyond ancient wound care practices is a recent phenomenon. It is essential to know the historical aspects of wound treatment (both successes and failures) in order to continue this progress and provide future direction. A survey of the literature shows that concepts such as "laudable pus" persisted for hundreds of years and that lasting discoveries and meaningful progress did not occur until grand-scale manufacturing and marketing started. Landmarks such as understanding the principles of asepsis/antisepsis, fundamental cellular research findings, knowledge about antibiotics/antimicrobials, moist wound healing, and the chemical and physical processes of wound healing have provided the foundation to guide major developments in wound management, including available evidence-based guidelines. Although research regarding interaction of basic wound management principles remains limited, the combined efforts of global research and clinical groups predict a bright future for improved wound management.
C1 [Moues, Chantal M.] Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, NL-3000 DR Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast & Reconstruct Surg, POB 1738, NL-3000 DR Rotterdam, Netherlands.
EM c.moues@erasmusmc.nl
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NR 103
TC 17
Z9 21
U1 0
U2 11
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAR
PY 2009
VL 55
IS 3
BP 16
EP +
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 424VQ
UT WOS:000264596800006
PM 19359707
DA 2026-07-24
ER

PT J
AU Surek, A
   Bozkurt, MA
   Gemici, E
   Kocatas, A
   Ferahman, S
   Seyhun, C
   Binboga, S
   Alis, H
AF Surek, Ahmet
   Bozkurt, Mehmet A.
   Gemici, Eyup
   Kocatas, Ali
   Ferahman, Sina
   Seyhun, Cemal
   Binboga, Sinan
   Alis, Halil
TI Treatment of Anastomotic Leaks With EndoVac After Low Anterior Resection
   in Colorectal Cancers
SO SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
LA English
DT Article
DE anastamotic leaks; EndoVac system; endoscop
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; THERAPY; SURGERY; EXPERIENCE;
   MANAGEMENT; LEAKAGES; RECTUM
AB Introduction: Endoscopic drainage should preferably be tried unless the abscess caused by the anastomotic leak is generalized and disseminated into the abdominal cavity. The aim of this study was to evaluate the results of patients treated with EndoVac. Patient and Methods: The medical records of patients who underwent low anterior resection and were treated using the EndoVac therapy system due to the detection of an anastomotic leak were retrospectively evaluated. Results: Thirty-three of the patients with detection of anastomotic leaks were treated using EndoVac therapy system. The mean number of application of the EndoVac therapy system was 5.8 (1 to 12) for each patient. Mean duration of hospitalization of the patients was 24.5 (9 to 92) days. Five patients underwent a second operation during the follow-up period after application of the EndoVac therapy system. In our study, the number of patients recovering without the need for additional treatment is 30 (30/33). Our success rate was 90.1%. Conclusions: The EndoVac therapy system is an alternative and helpful system in the treatment of colorectal anastomotic leaks without reoperation needed. It can also prevent permanent stoma.
C1 [Surek, Ahmet; Gemici, Eyup; Ferahman, Sina; Binboga, Sinan] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Bozkurt, Mehmet A.; Kocatas, Ali] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Alis, Halil] Istanbul Aydin Univ, Dept Gen Surg, Istanbul, Turkey.
   [Seyhun, Cemal] Lefkose State Hosp, Nicosia, Cyprus.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Istanbul Kanuni
   Sultan Suleyman Training & Research Hospital; Istanbul Aydin University
RP Bozkurt, MA (通讯作者)，Teyfik Saglam St 1-125,Bakirkoy, TR-34000 Istanbul, Turkey.
EM ahmetsurek82@hotmail.com; drsamet81@hotmail.com;
   sinaferahmantr@hotmail.com; seyhuncemal@gmail.com
RI Alış, Halil/AAJ-6721-2020; Ferahman, Sina/ABI-4440-2020; /ABC-5796-2020;
   kocatas, ali/HTR-2934-2023
OI Alış, Halil/0000-0002-8008-2776; Bozkurt, Mehmet
   Abdussamet/0000-0003-3222-9363; 
CR Alves A, 1999, J AM COLL SURGEONS, V189, P554, DOI 10.1016/S1072-7515(99)00207-0
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1530-4515
EI 1534-4908
J9 SURG LAPARO ENDO PER
JI Surg. Laparosc. Endosc. Pct. Tech.
PD AUG
PY 2021
VL 31
IS 4
BP 492
EP 496
DI 10.1097/SLE.0000000000000908
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UA5UZ
UT WOS:000685228300021
PM 33538549
DA 2026-07-24
ER

PT J
AU Tantu, MM
   Man, GM
   Paunescu, A
   Plesa, CF
   Nicolae, C
   Rogozea, LM
   Bisoc, A
   Mostafa, MF
   Nemes, RM
   Diaconu, M
AF Tantu, Monica Marilena
   Man, George Mihail
   Paunescu, Alina
   Plesa, Cristina Florentina
   Nicolae, Camelia
   Rogozea, Liliana Marcela
   Bisoc, Alina
   Mostafa, Marwa F.
   Nemes, Roxana Maria
   Diaconu, Magdalena
TI Advantages of Negative Pressure Therapy in Local Diabetic Foot Treatment
SO REVISTA DE CHIMIE
LA English
DT Article
DE diabetic foot; negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; ULCERS; MULTICENTER; PREVALENCE;
   AMPUTATION; ROMANIA; COST
AB Diabetic foot is a current public health problem and a late consequence of diabetes. Morbidity and mortality are significant, seriously affecting the patient's quality of life. Treatment of the diabetic foot is a long-lasting, highly resource-consumption process. Using negative pressure therapy leads to shorter hospitalization periods, better functional outcomes, significantly contributes to decreasing the number of amputations and improving patient's quality of life. 49 year-old patient is hospitalized with necrotizing at right foot and shank, neglected type II diabetes. It is performed amputation of atypical necessity, right leg, transtarsal, open stump. After successive debridements, negative pressure therapy is installed for a period of 24 days. This favors the formation of the granular bed, the remission of the infection, allowing grafting. The graft is partially integrated and plantar reconstruction is performed with sural reversal flap. The local and functional results are satisfactory, with the flap viability and the possibility of moving with support on the right leg, preventing the amputation of the shank. Negative pressure therapy has a multitude of advantages, it is preferable to conventional therapies, and it can have higher costs, but accelerates healing and improves the quality of life of the patient.
C1 [Tantu, Monica Marilena; Man, George Mihail; Paunescu, Alina] Univ Pitesti, Fac Sci Phys Educ & Informat, Med Assistance & Phys Therapy Dept, 1 Targu Din Vale Str, Pitesti 110040, Romania.
   [Plesa, Cristina Florentina; Nemes, Roxana Maria] Titu Maiorescu Univ Bucharest, Fac Med, 22 Dambovnicului Str, Bucharest, Romania.
   [Nicolae, Camelia] Carol Davila Univ Med & Pharm, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Rogozea, Liliana Marcela; Bisoc, Alina] Transilvania Univ Brasov, Fac Med, 29 Eroilor Blvd, Brasov 500036, Romania.
   [Mostafa, Marwa F.] Mansoura Univ, Fac Nursing, North Delta Sect, Mansoura 35516, Egypt.
   [Diaconu, Magdalena] Univ Med & Pharm Craiova, 2 Petru Rares Str, Craiova 200349, Romania.
C3 National University of Science & Technology POLITEHNICA Bucharest;
   University of Pitesti; Carol Davila University of Medicine & Pharmacy;
   Titu Maiorescu University; Carol Davila University of Medicine &
   Pharmacy; Transylvania University of Brasov; Egyptian Knowledge Bank
   (EKB); Mansoura University; University of Medicine & Pharmacy of Craiova
RP Bisoc, A (通讯作者)，Transilvania Univ Brasov, Fac Med, 29 Eroilor Blvd, Brasov 500036, Romania.
EM alina_bisoc@yahoo.com
RI Bisoc, Alina/HKM-4923-2023; Nemes, Roxana/AAD-6110-2019; Rogozea,
   Liliana/U-2809-2017; PAUNESCU, Alina/AIE-8805-2022; plesa, cristina
   florentina/AAM-6465-2020; Marilena Monica, Tantu/GSD-7373-2022
OI PAUNESCU, Alina/0000-0002-0228-4524; plesa, cristina
   florentina/0000-0003-2048-5431; Marilena Monica,
   Tantu/0000-0002-1038-7953
CR Atef Bayoumi AASAM, 2018, The Egyptian Journal of Hospital Medicine, V72, P4054, DOI [10.21608/ejhm.2018.9115, 10.21608/ejhm.2018.9115, DOI 10.21608/EJHM.2018.9115]
   [Anonymous], 2015, IDF Diabetes Atlas, V7
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   Guy Heidi, 2012, Nurs Times, V108, P20
   Jeffcoate WJ, 2018, DIABETES CARE, V41, P645, DOI 10.2337/dc17-1836
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   Kvitkina T, 2015, SYST REV-LONDON, V4, DOI 10.1186/s13643-015-0064-9
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   Popescu IG, 2018, ROM J MORPHOL EMBRYO, V59, P1001
   Ramsey SD, 1999, DIABETES CARE, V22, P382, DOI 10.2337/diacare.22.3.382
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schintler MV, 2012, DIABETES-METAB RES, V28, P72, DOI 10.1002/dmrr.2243
   Selvin E, 2004, CIRCULATION, V110, P738, DOI 10.1161/01.CIR.0000137913.26087.F0
   Sepúlveda G, 2009, CIR ESPAN, V86, P171, DOI 10.1016/j.ciresp.2009.03.020
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   Tântu MM, 2018, ROM J MORPHOL EMBRYO, V59, P895
   Tantu MM, 2014, ROM J MORPHOL EMBRYO, V55, P803
   Tantu MM, 2018, REV CHIM-BUCHAREST, V69, P3001
   Toosizadeh N, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135255
   Ulusal AE, 2011, ACTA ORTHOP TRAUMATO, V45, P254, DOI 10.3944/AOTT.2011.2283
   Vaidhya N, 2015, INDIAN J SURG, V77, pS525, DOI 10.1007/s12262-013-0907-3
   Van Acker K, 2001, ACTA CLIN BELG, V56, P21, DOI 10.1179/acb.2001.005
   Veresiu IA, 2015, DIABETES RES CLIN PR, V109, P293, DOI 10.1016/j.diabres.2015.05.020
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
NR 38
TC 6
Z9 6
U1 0
U2 10
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1307
EP 1310
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200040
DA 2026-07-24
ER

PT J
AU Sashida, Y
AF Sashida, Yasunori
TI New chest tube management maintained with negative pressure therapy
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Wound healing; negative pressure therapy; chest tube management;
   pressure sore; empyema; lung abscess
ID VACUUM-ASSISTED CLOSURE; FOUNDATION; DRAINAGE
AB Management of a chest tube, especially when lasting for a long period, becomes difficult. The orifice of thoracostomy where a tube is inserted is maintained sterile usually with water-tight sutures. The longer and tighter the sutures are placed, the more severely skin becomes sore by pressure. Recently not only pressure sores but also other various open wounds were successfully treated by negative pressure therapy. This study presents two cases of intrathoracic abscess which were successfully treated by chest tube maintained with negative pressure therapy. One case was a bed-ridden cerebral palsy patient with empyema thoracis and the other was a premature baby with lung abscess. Both needed a chest tube longer than a month. Negative pressure was applied not only in the abscess cavity but also in the wound of tube insertion, thus simultaneously draining the abscess and accelerating the wound healing of the tube insertion. It was gradually elevated from 20 to 50 H2O (14.7 to 36.7 mmHg), which is below the level of the physiologic forced inspiration, with a 10 cm H2O (7.4 mmHg) increase every other day. Both abscesses disappeared without a complication.
C1 Okinawa Prefectural Chubu Hosp, Div Plast Surg, Uruma City, Okinawa 9042293, Japan.
RP Sashida, Y (通讯作者)，Okinawa Prefectural Chubu Hosp, Div Plast Surg, Kyoku 281, Uruma City, Okinawa 9042293, Japan.
EM sashida@cosmos.ne.jp
CR Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Manzanet G, 2005, CHEST, V127, P2211, DOI 10.1378/chest.127.6.2211
   MILLER KS, 1987, CHEST, V91, P258, DOI 10.1378/chest.91.2.258
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Munnell ER, 1997, ANN THORAC SURG, V63, P1497, DOI 10.1016/S0003-4975(97)00082-9
   Palmen M, 2009, ANN THORAC SURG, V88, P1131, DOI 10.1016/j.athoracsur.2009.06.030
   Wongworawat MD, 2003, CLIN ORTHOP RELAT R, P45, DOI 10.1097/01.blo.0000084400.53464.02
NR 8
TC 0
Z9 0
U1 0
U2 8
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD APR
PY 2014
VL 48
IS 2
BP 155
EP 157
DI 10.3109/2000656X.2012.762005
PG 3
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AD2BM
UT WOS:000333037900012
PM 23829503
OA gold
DA 2026-07-24
ER

PT J
AU Deva, AK
   Buckland, CH
   Fisher, E
   Liew, SCC
   Merten, S
   McGlynn, V
   Gianoutsos, MP
   Baldwin, MAR
   Lendvay, PG
AF Deva, AK
   Buckland, CH
   Fisher, E
   Liew, SCC
   Merten, S
   McGlynn, V
   Gianoutsos, MP
   Baldwin, MAR
   Lendvay, PG
TI Topical negative pressure in wound management
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB Objective: To investigate the role of topical negative pressure (TNP) therapy in the management of difficult wounds.
   Design: Prospective consecutive patient series.
   Patients and setting: 30 patients referred to our tertiary plastic and reconstructive surgical service with wounds deemed unsuitable for reconstructive surgery were treated between November 1997 and the end of December 1998. The mean pretreatment duration of the wounds was 418 days (range, 8-1650 days). All wounds were at least Grade III pressure sores.
   Intervention: Topical negative pressure therapy (TNP) using the VAC device (KCI Medical, San Antonio, USA). Suction (75-125 mmHg) was continuous for the first 48 hours, then intermittent (2 min on, 5 min off).
   Main outcome measures: Achievement of wound healing endpoints: (1) complete healing of the wound; (2) obliteration of the wound cavity to allow surface dressings; or (3) closure of the wound by suture or skin graft.
   Results: TNP was successful in 26 out of 30 patients with mean therapy time of 35 days (range, 3-124 days). Healing was more rapid in acute (less than six weeks old) wounds. A reduction in the number of bacterial species and colonies was also observed during therapy.
   Conclusion: TNP can, in some circumstances, promote rapid secondary wound healing. A further randomised trial of TNP versus more traditional wound management modalities is justified.
C1 Prince Wales Hosp, Dept Plast & Reconstruct Surg, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Deva, AK (通讯作者)，6 Darghan St, Glebe, NSW 2037, Australia.
RI ; Merten, Sonja/KBQ-1858-2024
OI Deva, Anand/0000-0002-0314-7177; 
CR Altman D., 1990, PRACTICAL STAT MED R, V1st, P365, DOI [10.1201/9780429258589/practical-statistics-medical-research-douglas-altman, DOI 10.1201/9780429258589/PRACTICAL-STATISTICS-MEDICAL-RESEARCH-DOUGLAS-ALTMAN]
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   Strover AE, 1997, J ROY COLL SURG EDIN, V42, P119
NR 13
TC 51
Z9 68
U1 0
U2 5
PU AUSTRALASIAN MED PUBL CO LTD
PI SYDNEY
PA LEVEL 1, 76 BERRY ST, SYDNEY, NSW 2060, AUSTRALIA
SN 0025-729X
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD AUG 7
PY 2000
VL 173
IS 3
BP 128
EP 131
DI 10.5694/j.1326-5377.2000.tb125564.x
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 344RV
UT WOS:000088773400006
PM 10979377
DA 2026-07-24
ER

PT J
AU Tuñon, C
   De Lucas, J
   Cubilla, J
   Andrade, R
   Aguirre, M
   Cisneros, JZ
AF Tunon, Carlos
   De Lucas, Juan
   Cubilla, Jan
   Andrade, Rafael
   Aguirre, Miguel
   Cisneros, Julio Zuniga
TI Endoluminal vacuum therapy in the management of an esophago-pleural
   fistula as a complication of Boerhaave syndrome in a patient with
   eosinophilic esophagitis
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Boerhaave syndrome; Eosinophilic esophagitis; Vacuum-assisted closure;
   Endoscopy; Case report
ID PERFORATIONS
AB Background Boerhaave syndrome is an uncommon condition that represents about 15% of all esophageal perforation. A subset of these patients has eosinophilic esophagitis, a chronic inflammatory disease of the esophagus, that carries a risk of perforation of about 2%. Esophageal perforations can rarely result in the development of an esophago-pleural fistula. Treatment of esophago-pleural fistula represent a challenge due to lack of high quality evidence and scarce reported experience. Endoluminal vacuum-assisted therapy could have a role in the management by using the same principle applied in external wounds which provide wound drainage and tissue granulation. Case presentation We report a unique case of a 24-year-old man with eosinophilic esophagitis complicated with an esophageal rupture who developed an esophago-pleural fistula and was successfully managed with a non-surgical approach using endoluminal vacuum-assisted therapy. To our knowledge this could be the first experience reported in a patient with eosinophilic esophagitis. Conclusion Endoluminal vacuum-assisted therapy might be an effective and novel strategy in patients with eosinophilic esophagitis and esophago-pleural fistula as a consequence of Boerhaave syndrome. Appropriately designed studies are required.
C1 [Tunon, Carlos; De Lucas, Juan; Cubilla, Jan] Santo Tomas Hosp, Dept Gastroenterol, Panama City, Panama.
   [Andrade, Rafael; Aguirre, Miguel] Santo Tomas Hosp, Dept Thorac Surg, Panama City, Panama.
   [Cisneros, Julio Zuniga] Santo Tomas Hosp, Dept Internal Med, Panama City, Panama.
RP Cisneros, JZ (通讯作者)，Santo Tomas Hosp, Dept Internal Med, Panama City, Panama.
EM juliozc22@gmail.com
OI Cubilla Rodríguez, Jan Axel/0000-0002-5201-7344; Zúñiga Cisneros,
   Julio/0000-0002-4659-3468
CR Heits N, 2014, ANN THORAC SURG, V97, P1029, DOI 10.1016/j.athoracsur.2013.11.014
   de Moura DTH, 2019, WORLD J GASTRO ENDOS, V11, P329, DOI 10.4253/wjge.v11.i5.329
   Kaman L, 2011, GASTROENTEROLOGY RES, V6, P66
   Kim JH, 2015, CLIN ENDOSC, V48, P440, DOI 10.5946/ce.2015.48.5.440
   Loske G, 2010, ENDOSCOPY, V42, pE144, DOI 10.1055/s-0029-1244092
   Möschler O, 2015, ENDOSC INT OPEN, V3, pE554, DOI 10.1055/s-0034-1392568
   Rubicondo C, 2020, WORLD J SURG ONCOL, V18, DOI 10.1186/s12957-020-02073-6
   Runge TM, 2017, J CLIN GASTROENTEROL, V51, P805, DOI 10.1097/MCG.0000000000000718
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NR 11
TC 4
Z9 6
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD DEC 20
PY 2021
VL 21
IS 1
AR 484
DI 10.1186/s12876-021-02058-z
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XS5LO
UT WOS:000732950500009
PM 34930127
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Buckle, R
   Dhukani, A
   Bridges, RL
   Garcia, BC
AF Buckle, Rosemary
   Dhukani, Anum
   Bridges, Rayven L.
   Garcia, Barton C.
TI Hurricane Harvey Aftermath An Interdisciplinary Case Report on the
   Management of an Open Bimalleolar Fracture
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID CONSEQUENCES; INFECTION
AB Natural disasters, such as hurricanes and severe flooding, pose a threat of increased skin and soft-tissue infections, especially in the event of open fractures and wading through the waters. The purpose of this case study is to present a complex patient sustaining trauma resulting in an open bimalleolar fracture, multiple wounds, and exposure to a variety of water-borne pathogens during Hurricane Harvey in Houston, Texas, in 2017. He underwent multiple incision and drainage procedures, tissue cultures, and placement of antibiotic beads, with an application of external fixation to the left ankle. Several unique multidrug-resistant water-borne pathogens were identified, including Aeromonas hydrophila, Pseudomonas fluorescens/putida, and Serratia marcescens. Once the soft-tissue envelope was restored and infection cleared, a full-thickness rotational flap with tissue expansion was performed. Ultimate reconstruction was delayed several weeks and final left ankle open reduction and internal fixation was performed following antimicrobial treatment with split-thickness skin autograft and wound vacuum-assisted closure application. The patient was discharged after 28 days with no further complications. In instances such as these, all caretakers coming into contact with the patient should be aware of the potential risks of the possible infectious diseases and management to optimize the recovery following hydrologic disasters.
C1 [Buckle, Rosemary; Dhukani, Anum; Bridges, Rayven L.; Garcia, Barton C.] St Joseph Med Ctr, 1401 St Joseph Pkwy, Houston, TX 77002 USA.
RP Dhukani, A (通讯作者)，St Joseph Med Ctr, 1401 St Joseph Pkwy, Houston, TX 77002 USA.
EM adhukani@gmail.com
CR Bandino JP, 2015, AM J CLIN DERMATOL, V16, P399, DOI 10.1007/s40257-015-0138-4
   CBS NEWS, 2017, CBS NEWS        0904
   GUSTILO RB, 1976, J BONE JOINT SURG AM, V58, P453, DOI 10.2106/00004623-197658040-00004
   Halawi MJ, 2015, ORTHOPEDICS, V38, pE1025, DOI 10.3928/01477447-20151020-12
   MALISOW C, 2017, FLOODING HARVEY LEAD
   MCLAUGHLIN E C, CNN WEBSITE
   NATIONAL WEATHER SERVICE, 2017, MAJ HURR HARV AUG 25
   Rodriguez L, 2014, J TRAUMA ACUTE CARE, V77, P400, DOI 10.1097/TA.0000000000000398
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   Wuthisuthimethawee P, 2015, WORLD J SURG, V39, P842, DOI 10.1007/s00268-014-2663-3
NR 10
TC 1
Z9 1
U1 0
U2 3
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD MAR-APR
PY 2020
VL 110
IS 2
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA RP8KH
UT WOS:000641971500010
DA 2026-07-24
ER

PT J
AU Saghazadeh, S
   Rinoldi, C
   Schot, M
   Kashaf, SS
   Sharifi, F
   Jalilian, E
   Nuutila, K
   Giatsidis, G
   Mostafalu, P
   Derakhshandeh, H
   Yue, K
   Swieszkowski, W
   Memic, A
   Tamayol, A
   Khademhosseini, A
AF Saghazadeh, Saghi
   Rinoldi, Chiara
   Schot, Maik
   Kashaf, Sara Saheb
   Sharifi, Fatemeh
   Jalilian, Elmira
   Nuutila, Kristo
   Giatsidis, Giorgio
   Mostafalu, Pooria
   Derakhshandeh, Hossein
   Yue, Kan
   Swieszkowski, Wojciech
   Memic, Adnan
   Tamayol, Ali
   Khademhosseini, Ali
TI Drug delivery systems and materials for wound healing applications
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Wound healing; Drug delivery; Transdermal delivery; Microtechnologies;
   Nanotechnologies
ID VACUUM-ASSISTED CLOSURE; EPIDERMAL-GROWTH-FACTOR; MESOPOROUS SILICA
   NANOPARTICLES; MESENCHYMAL STEM-CELLS; CONTROLLED-RELEASE; POLYMERIC
   NANOPARTICLES; BIOMEDICAL APPLICATIONS; ALGINATE MICROSPHERES;
   RESPONSIVE POLYMERS; GOLD NANOPARTICLES
AB Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Saghazadeh, Saghi; Rinoldi, Chiara; Schot, Maik; Kashaf, Sara Saheb; Sharifi, Fatemeh; Jalilian, Elmira; Mostafalu, Pooria; Yue, Kan; Tamayol, Ali; Khademhosseini, Ali] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA.
   [Saghazadeh, Saghi; Rinoldi, Chiara; Schot, Maik; Kashaf, Sara Saheb; Sharifi, Fatemeh; Jalilian, Elmira; Mostafalu, Pooria; Yue, Kan; Tamayol, Ali; Khademhosseini, Ali] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA.
   [Rinoldi, Chiara; Swieszkowski, Wojciech] Warsaw Univ Technol, Fac Mat Sci & Engn, Mat Design Div, PL-02507 Warsaw, Poland.
   [Schot, Maik] Univ Twente, Dept Dev BioEngn, MIRA Inst Biomed Technol & Tech Med, Enschede, Netherlands.
   [Kashaf, Sara Saheb] Univ Chicago, Pritzker Sch Med, Med Scientist Training Program, Chicago, IL 60637 USA.
   [Sharifi, Fatemeh] Sharif Univ Technol, Sch Mech Engn, Tehran, Iran.
   [Nuutila, Kristo; Giatsidis, Giorgio] Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   [Derakhshandeh, Hossein; Tamayol, Ali] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68508 USA.
   [Memic, Adnan; Khademhosseini, Ali] King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21569, Saudi Arabia.
   [Khademhosseini, Ali] Univ Calif Los Angeles, Calif NanoSyst Inst CNSI, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA.
   [Khademhosseini, Ali] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA.
   [Khademhosseini, Ali] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90095 USA.
   [Jalilian, Elmira] UCL, UCL Inst Ophthalmol, London EC1V 9E1, England.
   [Khademhosseini, Ali] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University;
   Massachusetts Institute of Technology (MIT); Warsaw University of
   Technology; University of Twente; University of Chicago; Sharif
   University of Technology; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; University of Nebraska System;
   University of Nebraska Lincoln; King Abdulaziz University; University of
   California System; University of California Los Angeles; University of
   California System; University of California Los Angeles; University of
   California System; University of California Los Angeles; University of
   London; University College London; King Abdulaziz University
RP Tamayol, A (通讯作者)，900 N16th St,Room NH332, Lincoln, NE 68508 USA.; Khademhosseini, A (通讯作者)，4121-D Engn, Los Angeles, CA 90095 USA.
EM atamayol@unl.edu; khademh@ucla.edu
RI Sharifi, Fatemeh/AEU-4550-2022; Jalilian, Elmira/NWI-2230-2025; Tamayol,
   Ali/JXL-8870-2024; Yue, Kan/HMO-9219-2023; Giatsidis,
   Giorgio/B-4950-2013; Khademhosseini, Ali/A-9435-2010; Memić,
   Adnan/I-6138-2013
OI Sharifi, Fatemeh/0000-0003-4701-6926; Swieszkowski,
   Wojciech/0000-0003-4216-9974; Schot, Maik/0000-0001-6090-8000; Yue,
   Kan/0000-0003-1450-0279; Saheb Kashaf, Sara/0000-0003-1079-6009;
   Khademhosseini, Ali/0000-0002-2692-1524; Rinoldi,
   Chiara/0000-0002-4028-375X; Memić, Adnan/0000-0003-4639-8168
FU National Institutes of Health [HL092836, DE019024, EB012597, AR057837,
   DE021468, HL099073, EB008392]; University of Nebraska, Lincoln; Belgian
   American Educational Foundation (BAEF); King Baudouin Foundation (KBS);
   National Centre for Research and Development
   [STRATEGMED1/233224/10/NCBR/2014]; Nebraska Tobacco Settlement
   Biomedical Research Enhancement Funds
FX The authors declare no conflict of interests in this work. This research
   has been partially supported by the National Institutes of Health
   (HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392).
   A.T. acknowledges financial support from the University of Nebraska,
   Lincoln and Nebraska Tobacco Settlement Biomedical Research Enhancement
   Funds. S.S thanks Belgian American Educational Foundation (BAEF) and
   King Baudouin Foundation (KBS) for Henri Benedictus postdoctoral
   fellowship. C.R. would like to thank the funding from the National
   Centre for Research and Development in the frame of START project
   (STRATEGMED1/233224/10/NCBR/2014).
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NR 266
TC 688
Z9 777
U1 6
U2 657
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD MAR 1
PY 2018
VL 127
BP 138
EP 166
DI 10.1016/j.addr.2018.04.008
PG 29
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GL2AN
UT WOS:000436915500010
PM 29626550
OA Bronze
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Izzo, V
   Meloni, M
   Giurato, L
   Ruotolo, V
   Uccioli, L
AF Izzo, Valentina
   Meloni, Marco
   Giurato, Laura
   Ruotolo, Valeria
   Uccioli, Luigi
TI The Effectiveness of Negative Pressure Therapy in Diabetic Foot Ulcers
   with Elevated Protease Activity: A Case Series
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE foot ulcers; negative pressure; chronic wounds
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; MATRIX METALLOPROTEINASES;
   CONTROLLED-TRIAL; MANAGEMENT; EXPRESSION; MECHANISM; FLUID; PROMOGRAN;
   REPAIR
AB Objective: Despite several works have described the usefulness of negative pressure therapy (NPT) in the treatment of diabetic foot ulcers (DFUs), no studies have reported its ability in the proteases modulation in DFUs. The aim of this work was to evaluate the role of NPT as a protease-modulating treatment in DFUs.
   Approach: We conducted a prospective study of a series of diabetic patients affected by chronic DFUs. Each ulcer was assessed for matrix metalloproteinases (MMPs) activity with a protease status diagnostic test at the baseline and after 2 weeks of NPT.
   Results: Four patients were included. All patients had type 2 diabetes with a disease duration of approximate to 20 years. A1c was 79.5 +/- 15.3 mmol/mol. Ulcer area was >5 cm(2) in all cases. All wounds showed elevated protease activity (EPA) at the baseline. After 2 weeks, all patients showed a normalization of MMPs activity.
   Innovation: NPT showed its effectiveness in the reduction of EPA in chronic DFUs.
   Conclusion: This study confirms the role of NPT in the positive modulation of protease activity also in chronic DFUs.
C1 [Izzo, Valentina; Meloni, Marco; Giurato, Laura; Ruotolo, Valeria; Uccioli, Luigi] Univ Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata
RP Izzo, V (通讯作者)，Univ Tor Vergata, Dept Syst Med, Viale Oxford 81, I-00133 Rome, Italy.
EM valentina_izzo@virgilio.it
RI Meloni, Marco/AAB-9309-2019; uccioli, luigi/AAF-4844-2020; Izzo,
   Valentina/AAO-9874-2020
OI Meloni, Marco/0000-0003-3789-9622; 
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NR 35
TC 4
Z9 7
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JAN
PY 2017
VL 6
IS 1
BP 38
EP 42
DI 10.1089/wound.2016.0700
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EO2LA
UT WOS:000396526800005
PM 28116227
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lee, PJ
   Raniga, S
   Biyani, DK
   Watson, AJM
   Faragher, IG
   Frizelle, FA
AF Lee, P. J.
   Raniga, S.
   Biyani, D. K.
   Watson, A. J. M.
   Faragher, I. G.
   Frizelle, F. A.
TI Sacrococcygeal pilonidal disease
SO COLORECTAL DISEASE
LA English
DT Review
DE pilonidal; hair; surgery; complications; recurrence
ID Y ADVANCEMENT FLAP; RANDOMIZED CLINICAL-TRIAL; VACUUM-ASSISTED CLOSURE;
   SINUS-DISEASE; SURGICAL-TREATMENT; LIMBERG FLAP; Z-PLASTY; BASCOMS
   OPERATION; FOLLICLE REMOVAL; TOTAL EXCISION
AB Background Sacrococcygeal pilonidal is a common disease in active young adults. Many surgical methods have been proposed, although no clear consensus as to the optimal treatment has been reported. This review looks at the different surgical techniques available and examines the reported results of primary healing, recurrent disease and complications (including delayed healing).
   Method A literature search using the Medline database was performed to locate English language articles on surgery for pilonidal disease. Further articles were obtained from the references cited in the literature initially reviewed.
   Results Management should be tailored according to the individual and whether the disease is acute or chronic. Treatment should take into consideration hospital stay and return to work. Simple excision, curettage, partial lateral wall excision, or marsupialisation, are simple techniques with good results. They can be used for the initial surgery but their use is not recommended for recurrent disease. The modified rhomboid flap for recurrent disease has consistently shown positive results in terms of complication rates and recurrence.
   Conclusion We would recommend tailored treatment with simple excision for initial presentation and the modified rhomboid flap for recurrent disease.
C1 [Lee, P. J.; Raniga, S.; Frizelle, F. A.] Christchurch Hosp, Dept Surg, Colorectal Unit, Christchurch, New Zealand.
   [Biyani, D. K.; Watson, A. J. M.] Manchester Royal Infirm, Dept Surg, Colorectal Unit, Manchester M13 9WL, Lancs, England.
   [Faragher, I. G.] Western Hosp, Colorectal Unit, Melbourne, Vic, Australia.
C3 Christchurch Hospital New Zealand; University of Manchester; Western
   Health; Western Hospital
RP Frizelle, FA (通讯作者)，Christchurch Hosp, Dept Surg, Colorectal Unit, Riccarton Ave, Christchurch, New Zealand.
EM frank.frizelle@chmeds.ac.nz
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NR 81
TC 61
Z9 76
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD SEP
PY 2008
VL 10
IS 7
BP 639
EP 650
DI 10.1111/j.1463-1318.2008.01509.x
PG 12
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 339VI
UT WOS:000258605000003
PM 18384421
DA 2026-07-24
ER

PT J
AU Shalom, A
   Eran, H
   Westreich, M
   Friedman, T
AF Shalom, Avshalom
   Eran, Hadad
   Westreich, Melvyn
   Friedman, Tal
TI Our experience with a "homemade" vacuum-assisted closure system
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE negative pressure; dressing; cost-effective; improvised
ID SUBATMOSPHERIC PRESSURE; WOUND CONTROL
AB Background: Negative-pressure therapy for the closure of wounds, a technique to accelerate secondary wound healing, is clinically available as the V.A.C.(TM) system (KCI Inc, San Antonio, TX, USA). Budgetary considerations in our institution precluded widespread use of the expensive V.A.C.(TM) system in routine cases.
   Objectives: To develop a less expensive comparably effective dressing, based on the same principles.
   Methods: We used our "homemade" system to treat 15 patients with appropriate complex wounds. Their hospital charts were reviewed and assessed retrospectively. Cost analysis was performed comparing our dressing with the V.A.C.(TM) system.
   Results: Our homemade negative-pressure wound treatment system obtained results similar to what one could expect with the V.A.C.(TM) system in all parameters. Complications encountered were few and minor. Cost per day using our negative-pressure system for a 10 cm(2) wound is about US$1, as compared to US$22, utilizing the V.A.C.(TM) system.
   Conclusions: Our homemade negative-pressure system proved to be a good cost-effective treatment for wound closure in hospitalized patients, yielding results comparable to those of the more expensive V.A.C.(TM) system.
C1 [Friedman, Tal] Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
   Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel.
C3 Shamir Medical Center (Assaf Harofeh); Tel Aviv University; Tel Aviv
   University; Sackler Faculty of Medicine
RP Friedman, T (通讯作者)，Assaf Harofeh Med Ctr, Dept Plast Surg, IL-70300 Zerifin, Israel.
EM fredricag@asaf.health.gov.il
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NR 15
TC 15
Z9 18
U1 0
U2 2
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD AUG-SEP
PY 2008
VL 10
IS 8-9
BP 613
EP 616
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 352TN
UT WOS:000259520400016
PM 18847164
DA 2026-07-24
ER

PT J
AU McCord, SS
   Naik-Mathurian, BJ
   Murphy, KM
   McLane, KM
   Gay, AN
   Basu, CB
   Downey, CR
   Hollier, LH
   Olutoye, OO
AF McCord, Shannon S.
   Naik-Mathurian, Bindi J.
   Murphy, Kathy M.
   McLane, Kathy M.
   Gay, Andre N.
   Basu, C. Bob
   Downey, Cara R.
   Hollier, Larry H.
   Olutoye, Oluyinka O.
TI Negative pressure therapy is effective to manage a variety of wounds in
   infants and children
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUNDS
AB Negative pressure therapy (NPT) has been accepted as a valuable adjunct for wound closure in adults; however, reports on its effectiveness in young children and infants, including neonates, are limited. A retrospective chart review was conducted on children treated with NPT at a single institution between January 2003 and December 2005. Wound volumetric measurements were calculated at the start and end of therapy. Sixty-eight patients with 82 wounds were identified. The mean age was 8.5 years (range 7 days-18 years). Twenty patients (29%) were 2 years of age or younger, including eight neonates. Wound types included: pressure ulcers (n=13), extremity wounds (n=18), dehisced surgical wounds (n=19), open sternal wounds (n=10), wounds with fistulas (n=3), and complex abdominal wall defects (n=6). Low suction pressures (< 100mmHg) were generally used in children younger than 4 years of age. Following NPT, 93% of wounds decreased in volume. The average wound volume decrease was 80% (p < 0.01, n=56). NPT can be effectively used to manage a variety of wounds in children and neonates. No major complications were identified in our retrospective review. Prospective studies are required to better refine the use of this technology in children.
C1 Baylor Coll Med, Div Pediat Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   Texas Childrens Hosp, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital
RP Olutoye, OO (通讯作者)，Baylor Coll Med, Div Pediat Surg, Michael E DeBakey Dept Surg, 6621 Fannin St,CC650-00, Houston, TX 77030 USA.
EM oolutoye@bcm.tmc.edu
RI /AAJ-3357-2021
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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   *KCI, 2005, VAC THER CLIN GUID R
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   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Shilt JS, 2004, J PEDIATR ORTHOPED, V24, P482, DOI 10.1097/01241398-200409000-00006
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 17
TC 45
Z9 52
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2007
VL 15
IS 3
BP 296
EP 301
DI 10.1111/j.1524-475X.2007.00229.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 172IH
UT WOS:000246797000004
PM 17537115
DA 2026-07-24
ER

PT J
AU Pan, DY
   Yang, RQ
   Zhang, YL
   Chen, YM
   Wang, YH
   Xu, SX
AF Pan, Deyi
   Yang, Runqiao
   Zhang, Yalan
   Chen, Yuemei
   Wang, Yuhui
   Xu, Shixiong
TI Association between venous leg ulcers and knee osteoarthritis: A
   Mendelian randomization study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE association; knee osteoarthritis; leg ulcers; Mendelian randomization
ID VACUUM-ASSISTED CLOSURE; WOUND CARE PROCEDURES; STAPHYLOCOCCUS-AUREUS;
   PAIN INTENSITY; MICROBIOME; COMPONENT; VALIDITY; NERVE; SIGNS; CELL
AB To gain a clearer understanding of the relationship between venous leg ulcers (VLUs) and knee osteoarthritis (KOA), we performed a two-sample, bidirectional Mendelian randomization (MR) analysis in this study. The present MR was carried out using summary data from publicly available genome-wide association studies. After filtering single-nucleotide polymorphism (SNP), we applied a variety of MR methods including inverse variance weighted (IVW), MR egger, weighted mode, and weighted median. IVW analysis revealed that the genetic association between VLUs and KOA was not significant (beta = -0.017; SE 0.039; p = 0.658). In agreement with the IVW analysis, the findings of the weighted median estimator (beta = -0.017; SE 0.052, p = 0.751), MR egger (beta = 0.057; SE 0.084; p = 0.513), and weighted mode (beta = 0.060; SE 0.078; p = 0.456) indicated the absence of a significant genetic association between VLUs and KOA. Furthermore, reverse causality analysis suggested a lack of genetic relationship between KOA and VLUs. In conclusion, the present MR study does not suggest a causal relationship or reverse causal relationship between VLUs and KOA.
C1 [Pan, Deyi; Xu, Shixiong] Fujian Med Univ, Affiliated Hosp 2, Dept Emergency, Quanzhou, Peoples R China.
   [Yang, Runqiao] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Zhang, Yalan] Fujian Med Univ, Affiliated Hosp 2, Dept Pharm, Quanzhou, Peoples R China.
   [Chen, Yuemei] Fujian Med Univ, Affiliated Hosp 2, Thyroid Gland & Mammary Gland Surg Dept, Quanzhou, Peoples R China.
   [Wang, Yuhui] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
C3 Fujian Medical University; Chengdu University of Traditional Chinese
   Medicine; Fujian Medical University; Fujian Medical University; Tianjin
   University of Traditional Chinese Medicine
RP Xu, SX (通讯作者)，Fujian Med Univ, Affiliated Hosp 2, Dept Emergency, Quanzhou, Peoples R China.
EM xushixiong2024@163.com
FU Joint Funds for the innovation of science and Technology Fujian province
   [2023Y9230]
FX This work was funded by Joint Funds for the innovation of science and
   Technology Fujian province (Grant number: 2023Y9230).
CR Alavi A, 2016, J AM ACAD DERMATOL, V74, P627, DOI 10.1016/j.jaad.2014.10.048
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NR 31
TC 0
Z9 0
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2024
VL 32
IS 6
BP 895
EP 903
DI 10.1111/wrr.13229
EA OCT 2024
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA N5U9Z
UT WOS:001339755800001
PM 39444243
OA Bronze
DA 2026-07-24
ER

PT J
AU Hämäläinen, E
   Laurikka, J
   Huhtala, H
   Järvinen, O
AF Hamalainen, Eero
   Laurikka, Jari
   Huhtala, Heini
   Jarvinen, Otso
TI Risk factors for 1-year mortality after postoperative deep sternal wound
   infection
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Postoperative infection; mortality; deep sternal wound infection;
   mediastinitis; DSWI
ID VACUUM-ASSISTED CLOSURE; MEDIASTINITIS; COMPLICATIONS; SURGERY
AB Background and aims: A deep sternal wound infection is a life-threatening complication after cardiac surgery. This study was conducted to describe the mortality associated with postoperative deep sternal wound infections after cardiac surgery and to find risk factors linked to increased mortality in 1 year follow-up. Material and Methods: A total of 7973 open-heart surgeries were performed at Tampere University Hospital. Deep sternal wound infection patients were identified, their 1-year mortality status was recorded, and the related risk factors were analyzed. Results: We detected a total of 129 (1.6%) postoperative deep sternal wound infection patients. The 1-year mortality associated with a postoperative deep sternal wound infection was 20.2%. No preoperative or perioperative, statistically significant factors associated with increased 1-year mortality were found. A prolonged stay in an intensive care unit after surgery as well as stroke, delirium, wound secretion, and co-infection were associated with increased 1-year mortality. Conclusion: The risk factors found for increased 1-year mortality were all postoperative. The quality of surgical treatment as well as precise postoperative care and evaluation remain the most important factors to decrease later mortality due to deep sternal wound infections.
C1 [Hamalainen, Eero; Laurikka, Jari] Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33500, Finland.
   [Laurikka, Jari; Jarvinen, Otso] Tampere Univ, Dept Cardiothorac Surg, Heart Hosp, Tampere, Finland.
   [Huhtala, Heini] Tampere Univ, Fac Social Sci, Tampere, Finland.
C3 Tampere University; Tampere University; Tampere University
RP Hämäläinen, E (通讯作者)，Tampere Univ, Fac Med & Hlth Technol, Arvo Ylpon Katu 34, Tampere 33500, Finland.
EM eero.hamalainen@tuni.fi
RI ; LAURIKKA, Jari/F-2010-2014
OI Hämäläinen, Eero/0000-0003-1230-8654; Huhtala,
   Heini/0000-0003-1372-430X; LAURIKKA, Jari/0000-0001-7253-6048
CR Atkins BZ, 2011, AM J SURG, V202, P565, DOI 10.1016/j.amjsurg.2011.06.013
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   Hashimoto I, 2014, ARCH PLAST SURG-APS, V41, P253, DOI 10.5999/aps.2014.41.3.253
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NR 16
TC 6
Z9 11
U1 1
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD MAR
PY 2023
VL 112
IS 1
BP 41
EP 47
DI 10.1177/14574969221139709
EA DEC 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA A0BX9
UT WOS:000910530500001
PM 36453170
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Arumugam, PK
   Muthukumar, V
   Bamal, R
AF Arumugam, Praveen Kumar
   Muthukumar, Vamseedharan
   Bamal, Rahul
TI Utility of Shoelace Technique in Closure of Fasciotomy Wounds in
   Electric Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DELAYED PRIMARY CLOSURE
AB Fasciotomy is indicated to relieve compartment syndrome caused by electric burns. Many techniques are available to close the fasciotomy wounds including vacuum-assisted closure, skin grafting, and healing by secondary intention. This study assessed the shoelace technique in fasciotomy wound closure in patients with electric burns. The study included 19 fasciotomy wounds that were treated by shoelace technique (Group ST, n = 10 fasciotomy wounds) or by skin grafting/healing by secondary intention (Group C, n = 9 fasciotomy wounds). Data were collected for wound surface area, time to intervention, time to wound closure, rate of decrease in wound surface area after application of shoelace technique and associated complications.
   The mean time to intervention after fasciotomy was significantly lower in Group ST-7.6 +/- 3.8 days as compared to 15.8 +/- 5.3 days in Group C (P = .004). The median time to closure was also significantly lower in Group ST-7 days (range 6-10) as compared to Group C-20 days (range 12-48) (P < .001). Primary closure was achieved in 80% cases in the group ST and no complications were recorded. The shoelace technique is an economical, fast, and effective method of fasciotomy wound closure in electric burns, especially in high volume centers and resource-limited arms.
C1 [Arumugam, Praveen Kumar; Muthukumar, Vamseedharan; Bamal, Rahul] VM Med Coll & Safdarjung Hosp, Dept Burns Plast & Maxillofacial Surg, Delhi, India.
   [Bamal, Rahul] Griffith Univ, Sch Med, Gold Coast, Australia.
C3 Vardhman Mahavir Medical College & Safdarjung Hospital; Griffith
   University
RP Arumugam, PK (通讯作者)，VM Med Coll & Safdarjung Hosp, Dept Plast Burns & Maxillofacial Surg, Delhi 110029, India.
EM praveen.k2423@gmail.com
CR Almekinders L C, 1991, Orthop Rev, V20, P84
   BERMAN SS, 1994, AM J SURG, V167, P435, DOI 10.1016/0002-9610(94)90130-9
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   Huei T J, 2017, Ann Burns Fire Disasters, V30, P150
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   McLaughlin N, 2014, JAAPA-J AM ACAD PHYS, V27, P23, DOI 10.1097/01.JAA.0000446999.10176.13
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NR 21
TC 3
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2021
VL 42
IS 3
BP 538
EP 544
DI 10.1093/jbcr/iraa200
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA TX8ZY
UT WOS:000683376000028
PM 33161435
DA 2026-07-24
ER

PT J
AU Liang, Y
   Tian, H
   Liu, J
   Lv, YL
   Wang, Y
   Zhang, JP
   Huang, YS
AF Liang, Yi
   Tian, Hao
   Liu, Jie
   Lv, YanLing
   Wang, Yuan
   Zhang, JiaPing
   Huang, YueSheng
TI Application of stable continuous external electric field promotes wound
   healing in pig wound model
SO BIOELECTROCHEMISTRY
LA English
DT Article
DE Bioelectric field; Epidermis; Keratinocyte; Pseudopod;
   Re-epithelialisation; Differentiation
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; HUMAN KERATINOCYTES;
   MIGRATION; REGENERATION; STIMULATION; ADHESION; DISEASE
AB The mechanism underlying the effect of bioelectric field on wound healing in vivo has not been previously investigated. Here, we aimed to investigate the effects of an applied electric field (EF) on epidermal cell migration during wound healing. Using a Bama miniature pig wound model, we applied a power-up device (negative electrode in the wound centre and positive electrode around the wound) with pulsed electrical power, to apply a continuous, stable, and tolerable EF to the wound and provide directional signals for keratinocyte migration towards the wound centre. An EF of 100 mV/mm applied in the same direction as the bioelectric field accelerated wound healing. The keratinocytes exhibited regular and similar shapes, uniform arrangement, and an organised migration pattern. In contrast, 100 mV/mm applied countercurrent to the bioelectric field, delayed wound healing and hindered the keratinocyte migration towards the wound centre. Further, the cells were disorganised, misshapen, irregular, and disoriented. Via the application of a directional stable EF, this study morphologically identified the relationships among wound EF, keratinocyte migration, and wound healing and established theoretical and empirical foundations for the clinical application of bioelectric fields. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Liang, Yi; Tian, Hao; Liu, Jie; Lv, YanLing; Wang, Yuan; Huang, YueSheng] Third Mil Med Univ, Southwest Hosp, Army Med Univ, Inst Burn Res,State Key Lab Trauma Burn & Combine, Chongqing, Peoples R China.
   [Tian, Hao] PLA, Inst Burn & Orthoped, Gen Hosp Northern Theater Command, Shenyang 110016, Liaoning, Peoples R China.
   [Zhang, JiaPing] Third Mil Med Univ, Southwest Hosp, Army Med Univ, Dept Plast Surg,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China.
   [Huang, YueSheng] South Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Wound Repair,Inst Wound Repair, Shenzhen 518020, Peoples R China.
   [Huang, YueSheng] Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China.
C3 Army Medical University; Army Medical University; Southern University of
   Science & Technology; Jinan University; Jinan University
RP Zhang, JP (通讯作者)，Third Mil Med Univ, Southwest Hosp, Army Med Univ, Dept Plast Surg,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China.; Huang, YS (通讯作者)，South Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Wound Repair,Inst Wound Repair, Shenzhen 518020, Peoples R China.; Huang, YS (通讯作者)，Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China.
EM japzhang@aliyun.com; yshuangtmmu@163.com
RI wang, yuan/KIG-3389-2024; Liang, Yi/GLS-2479-2022
FU Key Program National Natural Science Foundation of China [81430042];
   National Nature Science Foundation of China (NSFC) [81873936];
   Technology Innovation and Application Development Project of Chongqing
   [cstc2019jscxmsxmX0101]; Clinical technology innovation and Cultivation
   Project of Army Medical University [CX2019JS102]; Special Foundation for
   Scientific Research of Health Care Industry of China [201202002];
   Project of Technology Innovation in Priority Research Field of the First
   Affiliated Hospital of Third Military Medical University
   [SWH2016ZDCX4201]; New Clinical Technology of Military Medicine and
   Medical Care of War Injury Program of the First Affiliated Hospital of
   Third Military Medical University [SWH2016YSCXYB-06]
FX This work was supported by the Key Program National Natural Science
   Foundation of China (81430042), National Nature Science Foundation of
   China (NSFC No. 81873936), Technology Innovation and Application
   Development Project of Chongqing (cstc2019jscxmsxmX0101), Clinical
   technology innovation and Cultivation Project of Army Medical University
   (CX2019JS102), Special Foundation for Scientific Research of Health Care
   Industry of China (201202002), Project of Technology Innovation in
   Priority Research Field of the First Affiliated Hospital of Third
   Military Medical University (SWH2016ZDCX4201), and New Clinical
   Technology of Military Medicine and Medical Care of War Injury Program
   of the First Affiliated Hospital of Third Military Medical University
   (SWH2016YSCXYB-06).
CR Allen GM, 2013, CURR BIOL, V23, P560, DOI 10.1016/j.cub.2013.02.047
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NR 51
TC 50
Z9 56
U1 3
U2 54
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1567-5394
EI 1878-562X
J9 BIOELECTROCHEMISTRY
JI Bioelectrochemistry
PD OCT
PY 2020
VL 135
AR 107578
DI 10.1016/j.bioelechem.2020.107578
PG 13
WC Biochemistry & Molecular Biology; Biology; Biophysics; Electrochemistry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Biophysics; Electrochemistry
GA OD3DD
UT WOS:000579730600008
PM 32534380
DA 2026-07-24
ER

PT J
AU Karl, T
   Billing, A
   Storck, M
AF Karl, T.
   Billing, A.
   Storck, M.
TI Economic and medical effects of a modern standard wound-healing
   treatment concept
SO GEFASSCHIRURGIE
LA German
DT Review
DE Wound care protocol; Hydroactive covering; VAC therapy; Therapy costs;
   Chronic wounds
ID CARE; DRESSINGS
AB The increasing number of patients with chronic wounds as well as the variety of new products for wound care make the development of a standard regimen necessary. One of the aims of a therapeutic standard is to avoid unnecessary and ineffective wound dressings and to adjust treatment to the stage of the wound-healing process. Additionally, synergistic logistic and economic effects can be achieved.
   A wound care protocol is easy to use, always available, and contains precise instructions. However, the initial phase of the introduction of a standard wound-healing treatment concept in two hospitals resulted in an increase in costs of between 21% and 169% (depending on the aspect). The daily costs for materials alone were between (sic) 7.24 and (sic) 7.26 in 2006 and between (sic) 8.66 and (sic) 8.79 in 2007. For each hospital bed, the costs were between (sic) 248.20 and (sic) 317.45 per year. Reasons for this phenomenon include an increased number of cases, an increase in the case mix index, inexperienced users, and the increased use of expensive treatments such as vacuum-assisted closure systems. Further prospective analyses are necessary to analyse the financial aspects of chronic wound care in major hospitals.
C1 [Karl, T.; Billing, A.] Klinikum Offenbach GmbH, Klin Gefasschirurg, D-63069 Offenbach, Germany.
   [Storck, M.] Stadt Klinikum Karlsruhe, Klin Gefass & Thoraxchirurg, Karlsruhe, Germany.
C3 Sana Klinikum Offenbach; Municipal Hospital Karlsruhe
RP Karl, T (通讯作者)，Klinikum Offenbach GmbH, Klin Gefasschirurg, Starkenburgring 66, D-63069 Offenbach, Germany.
EM dr.t.karl@web.de
RI /L-6893-2017
CR [Anonymous], COCHRANE DATABASE SY
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NR 14
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Z9 3
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0948-7034
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD AUG
PY 2009
VL 14
IS 4
BP 284
EP +
DI 10.1007/s00772-009-0675-3
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 482JB
UT WOS:000268880900005
DA 2026-07-24
ER

PT J
AU Mingot, J
   Lanzalaco, S
   Ferreres, G
   Tzanov, T
   Alemán, C
   Armelin, E
AF Mingot, Julia
   Lanzalaco, Sonia
   Ferreres, Guillem
   Tzanov, Tzanko
   Aleman, Carlos
   Armelin, Elaine
TI Theranostic nano-enabled polyurethane eso-sponges coupled to surface
   enhanced Raman scattering for detection and control of bacteria killing
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Polyurethane; Surface activation; Gold nanoparticles; Silver
   nanoparticles; Surface enhanced Raman scattering
ID SILVER NANOPARTICLES; MOLECULAR-MECHANISM; LIGNIN; ADHESIVE
AB Herein, a facile approach toward converting a three-dimensional polyurethane sponge (PUS), employed in endoluminal vacuum-assisted closure (endo-VAC) therapies, in a theranostic material able to detect and to inhibit bacteria growth, has been reported. The endo-VAC PUS presented sensitivity to Gram-positive and Gramnegative bacterial species thanks to its functionalization with gold and silver antibacterial nanoparticles (NPs). PUS with chitosan-stabilized Au-NPs achieved 5.26 f 0.17 logs and 2.78 f 0.34 logs of reduction of bacteria growth, whereas the sponges functionalized with phenolated lignin Ag-NPs offered slightly inferior values (4.77 f 0.36 logs and 2.03 f 0.37 logs, respectively), against Escherichia coli and Staphylococcus aureus pathogens, respectively, after the application of photothermal ablation. The in vitro antimicrobial studies were contrasted with the in-situ monitoring of bacteria localization and inactivation with excitation lasers of 532 and 785 nm wavelengths, respectively, in the Raman equipment. The novel theranostic nano-enabled antimicrobial PU sponges offer unprecedented possibilities for the improvement of the endo-VAC treatments and extrapolation of the methodology to other plastic-based implants to combat antimicrobial resistances.
C1 [Mingot, Julia; Lanzalaco, Sonia; Aleman, Carlos; Armelin, Elaine] Univ Politecnicacn Catalunya, Dept Engn Quim, IMEM BRT Grp, EEBE, C Eduard Maristany,10-14,Ed I,2 nd Floor, Barcelona 08019, Spain.
   [Mingot, Julia; Lanzalaco, Sonia; Aleman, Carlos; Armelin, Elaine] Univ Politecn Cataluna, Barcelona Res Ctr Multiscale Sci & Engn, C Eduard Maristany, 10-14, Basement S-1, Barcelona 08019, Spain.
   [Ferreres, Guillem; Tzanov, Tzanko] Univ Politecn Cataluna, Dept Engn Quim, GBMI Grp, ETSEIAAT, TR14 Rambla St Nebridi 22, Terrassa 08222, Spain.
   [Aleman, Carlos] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, C Baldiri Reixac 10-12, E-08028 Barcelona, Spain.
C3 Universitat Politecnica de Catalunya; Universitat Politecnica de
   Catalunya; Universitat Politecnica de Catalunya; University of
   Barcelona; Barcelona Institute of Science & Technology; Institut de
   Bioenginyeria de Catalunya
RP Lanzalaco, S; Armelin, E (通讯作者)，Univ Politecnicacn Catalunya, Dept Engn Quim, IMEM BRT Grp, EEBE, C Eduard Maristany,10-14,Ed I,2 nd Floor, Barcelona 08019, Spain.
EM sonia.lanzalaco@upc.edu; elaine.armelin@upc.edu
RI Alemán, Carlos/AAA-9954-2020; Mingot, Júlia/PJB-3223-2026; Armelin,
   Elaine/M-9375-2015; Lanzalaco, Sonia/M-9384-2016; Tzanov,
   Tzanko/F-1140-2016
OI Ferreres Cabanes, Guillem/0000-0003-3138-8506
FU MCIN/AEI [PID2021-125257OB-I00, CEX2023-001300-M]; ERDF "A way of making
   Europe"; European Union; Agencia de Gestio d'Ajuts Universitaris i de
   Recerca-AGAUR [2021SGR00387]; Horizon project "An Open Innovation Test
   Bed for Nano-Enabled Bio-Based PUR Foams and Composites" (BIOMAT)
   [H2020-953270]; AGAUR [2021 FISDU 00287]; Universitat Politecnica de
   Catalunya and Banco Santander [113 FPI-UPC 2018]; Generalitat de
   Catalunya
FX This project has received funding from the Grant PID2021-125257OB-I00,
   by MCIN/AEI/10.13039/501100011033 and by ERDF "A way of making Europe",
   by the European Union and from the Agencia de Gestio d'Ajuts
   Universitaris i de Recerca-AGAUR (2021SGR00387) and by Horizon 2020
   project "An Open Innovation Test Bed for Nano-Enabled Bio-Based PUR
   Foams and Composites" (BIOMAT), (H2020-953270). J. Mingot acknowledges
   the support of AGAUR for her PhD fellowship funding (Grant no 2021 FISDU
   00287). G. F acknowledges Universitat Politecnica de Catalunya and Banco
   Santander for his PhD grant (113 FPI-UPC 2018) . "This work is part of
   Maria de Maeztu Units of Excellence Programme CEX2023-001300-M/funded by
   MCIN/AEI/10.13039/501100011033". Support for the research of C. Aleman
   and T. Tzanov was also received through the prize "ICREA Academia" for
   excellence in research funded by the Generalitat de Catalunya.
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TC 5
Z9 5
U1 6
U2 23
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD OCT 1
PY 2024
VL 497
AR 154617
DI 10.1016/j.cej.2024.154617
EA AUG 2024
PG 15
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA D6M7W
UT WOS:001297310900001
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Blackham, AU
   Farrah, JP
   McCoy, TP
   Schmidt, BS
   Shen, P
AF Blackham, Aaron U.
   Farrah, Jason P.
   McCoy, Thomas P.
   Schmidt, Benjamin S.
   Shen, Perry
TI Prevention of surgical site infections in high-risk patients with
   laparotomy incisions using negative-pressure therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative-pressure therapy; Surgical site infections; Prevention;
   Laparotomy; Quality improvement
ID VACUUM-ASSISTED CLOSURE; COLORECTAL SURGERY; BOWEL PREPARATION; WOUND
   INFECTIONS; RANDOMIZED-TRIAL; COLLAGEN SPONGE; FOLLOW-UP; PROPHYLAXIS;
   REDUCTION; GUIDELINE
AB BACKGROUND: This study evaluates the efficacy of negative-pressure therapy (NPT) in preventing surgical site infections (SSIs) in high-risk surgical oncology patients.
   METHODS: A retrospective analysis of 191 operations for colorectal, pancreatic, or peritoneal surface malignancies was performed. Incisional NPT was used in patients with multiple SSI risk factors. Rates of SSIs were compared with patients treated with a standard sterile dressing (SSD).
   RESULTS: NPT was used in 104 patients, whereas SSDs were used in 87 patients. Despite being at an increased risk of SSI, patients treated with NPT developed fewer superficial incisional SSIs compared with SSD patients (6.7% vs 19.5%, P = .015). In a subgroup analysis of clean-contaminated cases, NPT was associated with fewer superficial incisional SSIs (6.0% vs 27.4%, P - .001), fewer total SSIs (16.0% vs 35.5%, P = .011), and fewer wound openings for any reason (16.0% vs 35.5%, P = .011).
   CONCLUSIONS: Our findings suggest that NPT decreases SSIs in high-risk surgical oncology patients. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Blackham, Aaron U.; Farrah, Jason P.; Schmidt, Benjamin S.; Shen, Perry] Wake Forest Sch Med, Dept Gen Surg, Winston Salem, NC 27157 USA.
   [McCoy, Thomas P.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University
RP Shen, P (通讯作者)，Wake Forest Sch Med, Dept Gen Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM pshen@wakehealth.edu
RI ; McCoy, Thomas P/PGU-0093-2026
OI Schmidt, Benjamin/0000-0002-4947-2725; McCoy, Thomas
   P/0000-0003-4813-1248
CR [Anonymous], SURG SIT INF PREV TR
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NR 40
TC 96
Z9 116
U1 0
U2 8
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
J9 AM J SURG
JI Am. J. Surg.
PD JUN
PY 2013
VL 205
IS 6
BP 647
EP 654
DI 10.1016/j.amjsurg.2012.06.007
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 156DY
UT WOS:000319802500005
PM 23375758
DA 2026-07-24
ER

PT J
AU Ahuja, NK
   Datiashvili, RO
AF Ahuja, Naveen K.
   Datiashvili, Ramazi O.
TI Biobrane in the management of critical microsurgical wounds of the upper
   extremity
SO MICROSURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN SUBSTITUTE; FREE-FLAP; RECONSTRUCTION;
   COVERAGE; NECK; HEAD; COMPLICATIONS; INFECTIONS; LEVEL
AB Purpose: Evolving soft tissue necrosis and/or edema can complicate microsurgical reconstruction by leading to open wounds with exposure of critical structures: anastamosed vessels, nerves, and tendons. Not infrequently, primary closure of these wounds is not possible. Immediate skin grafting may lead to anatomical and/or functional failure of reconstructed structures, compromising immediate or long-term functional outcomes. In addition, local tissues are often unavailable, and free tissue transfer in those settings could be ill-advised, especially for small wounds. Methods: All of the senior author's microsurgical cases were reviewed. Four cases of replantation and one microsurgical reconstruction, where biologic dressings were used to treat critical wounds, were identified and are presented in this study along with an algorithm for the management of these types of wounds. Results: Biologic dressings are simple, effective, and reliable tools for intermediate treatment of critical microsurgical wounds. Flap or replant viability was preserved in 100% of cases without compromising functional results. Conclusions: Biologic dressings can be used safely to treat microsurgical wounds with exposed critical structures. This use of a biologic dressing greatly simplifies the management of these types of wounds, avoiding the need for complex surgical intervention. VVC 2011 Wiley Periodicals, Inc. Microsurgery 32: 196-200, 2012.
C1 [Ahuja, Naveen K.; Datiashvili, Ramazi O.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Ahuja, NK (通讯作者)，Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Div Plast Surg, Newark, NJ 07103 USA.
EM naveen.ahuja@gmail.com
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NR 40
TC 5
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD MAR
PY 2012
VL 32
IS 3
BP 196
EP 200
DI 10.1002/micr.20966
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 908ZR
UT WOS:000301532100005
PM 22113974
DA 2026-07-24
ER

PT J
AU Kalish, J
   Hamdan, A
AF Kalish, Jeffrey
   Hamdan, Allen
TI Management of diabetic foot problems
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; LOWER-EXTREMITY
   REVASCULARIZATION; VACUUM-ASSISTED CLOSURE; CRITICAL LIMB ISCHEMIA;
   DORSAL PEDAL ARTERY; STAGE RENAL-DISEASE; DOUBLE-BLIND; INFRAPOPLITEAL
   ANGIOPLASTY; RESOURCE UTILIZATION
AB Background: Diabetic foot problems and their complications are a medical and economic challenge to the health care system and require an aggressive multidisciplinary approach to achieve limb salvage. The goals of this review article are to delve into this comprehensive topic and summarize key points regarding diabetic foot problems from the perspective of the vascular specialist treating these patients.
   Methods. The MEDLINE database was searched to identify articles on this topic.
   Results. We found 112 relevant articles. These were used to provide current data on (1) the pathogenesis leading to diabetic foot lesions (ie, the etiologic triad of ischemia, neuropathy, and infection), (2) the clinical presentation of these foot lesions and their systemic manifestations, (3) the optimal methods of diagnostic evaluation, including noninvasive testing and arteriography, (4) treatment selection guidelines to help delineate which patients require revascularization, and (5) medical and interventional treatments, including prevention strategies, wound healing strategies, use of antibiotics, and endovascular and open surgical options for revascularization.
   Conclusions: The data presented in this review article allow, vascular clinicians to optimize patient care and achieve effective limb salvage for this growing segment of the population. (J Vase Surg 2010;51:476-86.)
C1 [Kalish, Jeffrey; Hamdan, Allen] Beth Israel Deaconess Med Ctr, Div Vasc & Endovasc Surg, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
EM jeffrey.kalish@bmc.org
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NR 111
TC 57
Z9 81
U1 0
U2 14
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD FEB
PY 2010
VL 51
IS 2
BP 476
EP 486
DI 10.1016/j.jvs.2009.08.043
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 556PG
UT WOS:000274602800030
PM 19853400
DA 2026-07-24
ER

PT J
AU Durmishi, Y
   Gervaz, P
   Bühler, L
   Bucher, P
   Zufferey, G
   Al-Mazrouei, A
   Morel, P
AF Durmishi, Y.
   Gervaz, P.
   Buehler, L.
   Bucher, P.
   Zufferey, G.
   Al-Mazrouei, A.
   Morel, Ph.
TI Vacuum-assisted abdominal closure:: its role in the treatment of complex
   abdominal and perineal wounds
SO JOURNAL DE CHIRURGIE
LA French
DT Article
DE treatment; adominal wall; VAC; Fournier's gangrene; open abdomen.
ID OPEN ABDOMEN; COMPARTMENT SYNDROME; FASCIAL CLOSURE; EXPERIENCE;
   GANGRENE; TRAUMA
AB Introduction: Vacuum-assisted closure (VAC) is a promising approach for the management of complex abdominal and perineal wounds. This paper summarizes our experience with this therapeutic modality and demonstrates its efficacity in difficult situations.
   Patients and methods: From January 2003 until December 2005, 48 patients (age 30-89) were treated with VAC therapy for open abdomen, infected laparotomy wounds, or tissue loss due to debridement of Fournier's gangrene. Wound dressings were changed every 2-3 days.
   Results: Thirty eight patients (79%) had major co-morbid conditions liable to impact negatively on wound healing. The treatment duration with VAC varied from 20-30 days with an average of eleven dressing changes (minimum 3-maximum 18). Treatment was effective in all patients. Spontaneous closure was achieved in 36 cases (75%); nine patients (19%) required a split-thickness skin graft, and three (6%) underwent delayed secondary closure. Conclusion: In our institution, VAC has become the treatment of choice for complex abdominal and perineal wounds. It is a safe, simple, and effective technique to speed wound healing and it has reduced the duration of hospital treatment in difficult clinical situations and in patients whose general condition is often severely compromised.
C1 [Durmishi, Y.; Gervaz, P.; Buehler, L.; Bucher, P.; Zufferey, G.; Al-Mazrouei, A.; Morel, Ph.] Hop Cantonal Univ Geneva, Dept Chirurg, CH-1211 Geneva, Switzerland.
C3 University of Geneva
RP Durmishi, Y (通讯作者)，Hop Cantonal Univ Geneva, Dept Chirurg, 24 Rue Micheli du Crest, CH-1211 Geneva, Switzerland.
EM ymer.durmishi@hcuge.ch
OI Buhler, Leo/0000-0002-9461-8498
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Bonnamy C, 2000, ANN CHIR, V125, P982, DOI 10.1016/S0003-3944(00)00411-9
   Cothren CC, 2006, AM J SURG, V192, P238, DOI 10.1016/j.amjsurg.2006.04.010
   Eke N, 2000, BJS-BRIT J SURG, V87, P718, DOI 10.1046/j.1365-2168.2000.01497.x
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
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NR 16
TC 12
Z9 15
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0021-7697
J9 J CHIR-PARIS
JI J. Chir.
PD MAY-JUN
PY 2007
VL 144
IS 3
BP 209
EP 213
DI 10.1016/S0021-7697(07)89516-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 254PU
UT WOS:000252600200005
PM 17925713
DA 2026-07-24
ER

PT J
AU Antony, S
   Terrazas, S
AF Antony, S
   Terrazas, S
TI A retrospective study: Clinical experience using vacuum-assisted closure
   in the treatment of wounds
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE wound VAC; wound healing
ID NEGATIVE-PRESSURE; TRIAL
AB We report the results of our wound care experience using the wound vac as an adjunct therapy in the treatment of sternal, spinal, and lower-extremity wounds. This is a retrospective study in which 42 patients were evaluated between 1999 and 2002 for nonhealing sternal, spinal, and lower-extremity wounds. There were 12 patients With sternal wounds with a variety of pathogens who were treated with antimicrobials along with the wound VAC. The VAC was applied for an average of 12 days, and all 12 patients went onto complete closure by the end of four weeks. There were 14 patients in the lower-extremity wound group, again, with a variety of pathogens. The VAC was placed for an average of 29.3 days to achieve closure along with the wound VAC. There were 16 spinal wound patients with a variety of pathogens. All the patients received antimicrobial therapy, with the average duration of the VAC beings 27.6 days and closure taking about eight weeks. The wound VAC, along with appropriate antimicrobial therapy and surgery, appears to help reduce the number of days to healing, along with a reduction in the number hospital days and possibly costs to the health system.
C1 Texas Tech Univ, Ctr Hlth Sci, US Oncol PA, El Paso, TX USA.
   Diamond Rehabil Ctr, El Paso, TX USA.
C3 Texas Tech University System; Texas Tech University
RP Antony, S (通讯作者)，7848 Gateway E, El Paso, TX 79935 USA.
EM santony@elp.rr.com
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NR 19
TC 20
Z9 33
U1 0
U2 1
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD AUG
PY 2004
VL 96
IS 8
BP 1073
EP 1077
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 840QL
UT WOS:000222874100021
PM 15303413
DA 2026-07-24
ER

PT J
AU Juhl, AA
   Koudahl, V
   Damsgaard, TE
AF Juhl, Alexander Andersen
   Koudahl, Vibeke
   Damsgaard, Tine Engberg
TI Deep sternal wound infection after open heart surgery - reconstructive
   options
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Review
DE deep sternal wound infection; TNP; mediastinitis; surgical flaps;
   reconstructive surgical procedures; sternum surgery; surgical wound
   infection; review; open heart surgery
ID VACUUM-ASSISTED CLOSURE; EMORY 20-YEAR EXPERIENCE; MUSCLE FLAPS;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; STERNOTOMY WOUNDS;
   PECTORALIS FLAPS; MANAGEMENT; THERAPY; IMPACT
AB Objectives. The management of sternal defects arisen after deep sternal wound infection is challenging and often requires extensive interdisciplinary teamwork between plastic and thoracic surgeons. In this study, the published literature on methods used to reconstruct sternal defects arisen as a result of deep sternal wound infection after open-heart surgery will be reviewed. Design. The Cochrane, Embase, PubMed, and SveMed + databases were searched in December 2011. Only papers regarding treatment of deep sternal wound infection after open-heart surgery in adults were included. Results. The literature search identified 224 original papers that met the inclusion criteria. The majority dealt with surgical techniques. None of the studies regarding reconstructive options were designed as randomized controlled trials, and the levels of evidence are generally low. Conclusion. The treatment of deep sternal wound infection has evolved considerably, but there is still little consensus regarding optimal surgical management and a general lack of a standard treatment protocol. The use of muscle flap transposition is well documented. Recent studies recommend the use of topical negative pressure therapy as an adjunct to surgical reconstruction.
C1 [Juhl, Alexander Andersen; Koudahl, Vibeke; Damsgaard, Tine Engberg] Aarhus Univ Hosp, Dept Plast Surg, DK-8000 Aarhus C, Denmark.
C3 Aarhus University
RP Juhl, AA (通讯作者)，Aarhus Univ Hosp, Dept Plast Surg, Norrebrogade 44, DK-8000 Aarhus C, Denmark.
EM alexander@oncology.dk
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NR 30
TC 20
Z9 27
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD OCT
PY 2012
VL 46
IS 5
BP 254
EP 261
DI 10.3109/14017431.2012.674549
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 002LU
UT WOS:000308534400002
PM 22404844
DA 2026-07-24
ER

PT J
AU Ngo, QD
   Vickery, K
   Deva, AK
AF Ngo, Quan D.
   Vickery, Karen
   Deva, Anand K.
TI The effect of topical negative pressure on wound biofilms using an in
   vitro wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BACTERIAL BIOFILMS; RESISTANCE; THERAPY;
   SILVER; OXYGEN; ACID
AB Chronic non-healing wounds affect a significant number of patients worldwide. Although the etiologies of these wounds are varied, bacterial infection has been suggested as a major factor responsible for the perpetual inflammation and tissue destruction observed in such wounds. Recent evidence has emerged suggesting that bacterial biofilms in particular may have a significant role in this process. At the same time, topical negative pressure dressing is gaining acceptance as a therapy which promotes healing in recalcitrant wounds. In this study an in vitro Pseudomonas aeruginosa biofilm model was developed to mimic potential surface wound biofilms. Topical negative pressure dressing was applied to the model and the effects of topical negative pressure dressing on the in vitro wound biofilms were examined using both quantitative microbiological counting technique and imaging studies. The results demonstrated a small but statistically significant reduction in biofilm bacteria at 2 weeks when exposed to topical negative pressure. When this was combined with silver impregnated foam, the reduction was far more significant and was observable within 24 hours. Microscopically, it was also noted that topical negative pressure compressed the biofilm architecture with a reduction in thickness and diffusion distance.
C1 [Ngo, Quan D.] Univ Sydney, Dept Maxillofacial & Plast Surg, S Western Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Vickery, Karen; Deva, Anand K.] Macquarie Univ, SIRG, Australian Sch Adv Med, N Ryde, NSW, Australia.
C3 University of Sydney; Macquarie University
RP Ngo, QD (通讯作者)，70 Meadows Rd, Mt Pritchard, NSW 2170, Australia.
EM drain_master@hotmail.com
OI ngo, quan/0000-0003-0415-0762; Deva, Anand/0000-0002-0314-7177; Vickery,
   Karen/0000-0003-0998-1370
FU Department of Infectious Disease, University of Sydney
FX The work presented herein was made possible with very generous help from
   the staff at the Infectious Disease and Virology Departments at the
   University of Sydney, especially Prof. Y. Cossart, Prof. R. Kearney, Ms.
   Kate Gilchrist, and Dr. Jean Zou. Funding was provided by the Department
   of Infectious Disease, University of Sydney.
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NR 42
TC 65
Z9 73
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2012
VL 20
IS 1
BP 83
EP 90
DI 10.1111/j.1524-475X.2011.00747.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 882GE
UT WOS:000299551000054
PM 22126340
DA 2026-07-24
ER

PT J
AU Fleck, TM
   Koller, R
   Giovanoli, P
   Moidl, R
   Czerny, M
   Fleck, M
   Wolner, E
   Grabenwoger, M
AF Fleck, TM
   Koller, R
   Giovanoli, P
   Moidl, R
   Czerny, M
   Fleck, M
   Wolner, E
   Grabenwoger, M
TI Primary or delayed closure for the treatment of poststernotomy wound
   infections?
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DEEP STERNAL INFECTION; BYPASS GRAFT-SURGERY;
   MUSCLE FLAPS; POSTOPERATIVE MEDIASTINITIS; STERNOTOMY; MANAGEMENT;
   COMPLICATIONS; EXPERIENCE; IRRIGATION
AB Objective: The methods of primary versus delayed wound closure for the treatment of sternal wound infections after cardiac surgery were retrospectively compared.
   Methods: From January 2001 to March 2003, 132 patients (median age 66 years, male to female ratio 88:44),with sternal wound infection after cardiac surgery were treated at our department. After thorough debridement, 35 patients received preconditioning of the wound before implementation of definitive-therapy; the remainder (97 patients) were treated with immediate closure.
   Results: From the 35 patients with preconditioning, 19 patients proceeded to delayed primary closure, whereas the remaining 14 patients were referred to plastic reconstruction with a pectoralis muscle flap. Primary success rate in this group was 100%.
   In the immediate primary closure group, 33 patients experienced 1 or more therapy failures, resulting in a recurrence rate of 39%. Fifteen patients received a pectoralis muscle flap as definite treatment modality.
   Conclusions: Immediate primary closure is associated with a high rate of local infection recurrence. Surgical debridement and conditioning of the wound until resolution of infections with delayed primary closure or plastic reconstruction is suggested as the more appropriate treatment modality, with promising results.
C1 Univ Vienna, Dept Cardiothorac Surg, AKH Vienna, A-1090 Vienna, Austria.
   Univ Vienna, Dept Plast & Reconstruct Surg, AKH Vienna, A-1090 Vienna, Austria.
C3 University of Vienna; University of Vienna
RP Fleck, TM (通讯作者)，Univ Vienna, Dept Cardiothorac Surg, AKH Vienna, Leitstelle 20A,Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM t9204604@hotmail.com
OI Czerny, Martin/0000-0003-4766-9775
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 27
Z9 30
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAR
PY 2004
VL 52
IS 3
BP 310
EP 314
DI 10.1097/01.sap.0000105524.75597.e0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 802HN
UT WOS:000220154700023
PM 15156988
DA 2026-07-24
ER

PT J
AU Aliu, O
   Diaz-Garcia, RJ
   Zhong, L
   McGlinn, E
   Chung, KC
AF Aliu, Oluseyi
   Diaz-Garcia, Rafael J.
   Zhong, Lin
   McGlinn, Evan
   Chung, Kevin C.
TI Mortality Trends and the Effects of Debridement Timing in the Management
   of Mediastinitis in the United States, 1998 to 2010
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; STERNAL WOUND
   INFECTIONS; POSTSTERNOTOMY MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS;
   CONVENTIONAL TREATMENT; RISK-FACTORS; THERAPY; COMPLICATIONS; HIP
AB Background: The authors examined the relationship between debridement delay and mortality for mediastinitis patients. The authors also assessed mortality trends for mediastinitis patients between 1998 and 2010.
   Methods: The authors conducted a retrospective cross-sectional study with data from the Nationwide Inpatient Sample, 1998 to 2010. They studied adult patients, 18 years of age or older, who were surgically treated for mediastinitis. They used a logistic regression model adjusted for patient demographic and clinical characteristics to evaluate the association between timing of first operative debridement and in-hospital mortality. Using their logistic model, they calculated the adjusted probability of in-hospital mortality for each year of the study.
   Results: Results showed that initial debridement after the fourth day of admission increased the odds of in-hospital mortality by 50 percent (odds ratio, 1.5; 95 percent confidence interval, 1.0 to 2.1). In addition, the adjusted probability of in-hospital mortality for an average patient treated for mediastinitis decreased from 10.6 percent in 1998 to 3.1 percent in 2010.
   Conclusion: There is a survival advantage from timely initial debridement in mediastinitis patients.
C1 [Aliu, Oluseyi; Diaz-Garcia, Rafael J.; Zhong, Lin; McGlinn, Evan; Chung, Kevin C.] Univ Michigan Hlth Syst, Sect Plast Surg, Dept Surg, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Chung, KC (通讯作者)，Univ Michigan Hlth Syst, Sect Plast Surg, Taubman Ctr 2130, 1500 East Med Ctr Dr,SPC 5340, Ann Arbor, MI 48109 USA.
EM kecchung@med.umich.edu
RI Diaz-Garcia, Rafael/JGD-0932-2023
OI Chung, Kevin/0000-0002-2822-3164
FU Robert Wood Johnson Foundation Clinical Scholars Program/VA; National
   Institute of Arthritis and Musculoskeletal and Skin Diseases [2K24
   AR053120-06, R01 AR047328-06, R01 AR062066]; National Institute on Aging
FX This study was supported by the Robert Wood Johnson Foundation Clinical
   Scholars Program/VA Scholar (to O.A.), and by a Midcareer Investigator
   Award in Patient-Oriented Research (2K24 AR053120-06 and R01
   AR047328-06) from the National Institute of Arthritis and
   Musculoskeletal and Skin Diseases, and R01 AR062066 from the National
   Institute of Arthritis and Musculoskeletal and Skin Diseases and the
   National Institute on Aging (to K.C.C.).
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NR 22
TC 6
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2014
VL 134
IS 3
BP 457E
EP 463E
DI 10.1097/PRS.0000000000000422
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB2LZ
UT WOS:000349460300012
PM 25158723
DA 2026-07-24
ER

PT J
AU Chen, SJ
   Han, XX
AF Chen, Shu-jun
   Han, Xiao-xian
TI Transoral negative-pressure catheter drainage of a retropharyngeal and
   mediastinal abscess
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article
ID DESCENDING NECROTIZING MEDIASTINITIS; VACUUM-ASSISTED CLOSURE; DEEP NECK
   ABSCESSES; GUIDED DRAINAGE; NEEDLE ASPIRATION; MANAGEMENT; CHILDREN;
   INFECTIONS; EXPERIENCE; 10-YEAR
AB Purpose: A retropharyngeal abscess (RPA) is an extremely rare entity in adults that has a tendency to spread vertically and cause a mediastinal abscess. Traditionally, immediate aggressive drainage is recommended via a transcervical or transthoracic approach for the treatment of a retropharyngeal abscess with mediastinal extension. Here, we present a case of a retropharyngeal and mediastinal abscess using a transoral negative-pressure catheter drainage approach.
   Patients and methods: A 24-year-old woman was admitted with a 4-day history of severe sore throat and painful swallowing. Computed tomography identified a retropharyngeal abscess extending to the upper posterior mediastinum. We performed transoral negativepressure catheter drainage.
   Results: The postoperative course was uneventful. The patient reported a rapid improvement in symptoms and had a good tolerance of the catheters in the nasal cavity. At 2 years postoperatively, physical examinations revealed no recurrence or surgical complications.
   Conclusions: Transoral negative-pressure catheter drainage is a minimally invasive operation for the treatment of RPA in adults with or without a mediastinal abscess. This method could be recommended as an alternative approach in such cases. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chen, Shu-jun; Han, Xiao-xian] 252nd Hosp PLA, Dept Oral & Maxillofacial Surg, Baoding 071000, Peoples R China.
RP Chen, SJ (通讯作者)，252nd Hosp PLA, Dept Oral & Maxillofacial Surg, Baoding 071000, Peoples R China.
EM shujunchen001@gmail.com
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NR 39
TC 4
Z9 6
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
EI 1532-818X
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD MAY-JUN
PY 2014
VL 35
IS 3
BP 313
EP 317
DI 10.1016/j.amjoto.2014.02.005
PG 5
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA AH2EK
UT WOS:000335934100007
PM 24629587
DA 2026-07-24
ER

PT J
AU Mavros, MN
   Mitsikostas, PK
   Alexiou, VG
   Peppas, G
   Falagas, ME
AF Mavros, M. N.
   Mitsikostas, P. K.
   Alexiou, V. G.
   Peppas, G.
   Falagas, M. E.
TI Antimicrobials as an adjunct to pilonidal disease surgery: a systematic
   review of the literature
SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
LA English
DT Review
ID GENTAMICIN-COLLAGEN SPONGE; VACUUM-ASSISTED CLOSURE; RANDOMIZED
   CONTROLLED-TRIAL; STERNAL WOUND INFECTIONS; 3-YEAR FOLLOW-UP; PRIMARY
   SUTURE; DOUBLE-BLIND; CARDIAC-SURGERY; SINUS-DISEASE; RECTAL-CANCER
AB Surgical site infection (SSI) after pilonidal disease surgery can lead to serious complications. We systematically searched the PubMed, Scopus, and ClinicalTrials.gov databases for studies evaluating the use of antimicrobials as an adjunct to pilonidal disease surgery. We identified 12 eligible studies [nine randomized controlled trials (RCTs), three retrospective cohort studies], enrolling a total of 1,172 patients. No difference was observed when single-dose prophylaxis was compared to no prophylaxis or to a long course of antibiotics (seven studies, 690 patients). Similarly, gentamicin collagen sponges (GCS) did not appear to be beneficial when compared with no GCS (with primary or secondary closure; four studies, 402 patients). One study (80 patients) reported faster healing and lower SSI and recurrence rates with GCS than a 7-day course of antibiotics. The clinical heterogeneity precluded a formal meta-analysis. Although the generalization of our findings may be limited by the relative paucity and clinical heterogeneity of the existing studies, prophylactic antibiotics or GCS did not appear to be beneficial in promoting healing or reducing SSI or recurrence rates. Large, double-blind, placebo-controlled RCTs are warranted in order to further elucidate this issue.
C1 [Mavros, M. N.; Mitsikostas, P. K.; Alexiou, V. G.; Peppas, G.; Falagas, M. E.] Alfa Inst Biomed Sci, Athens 15123, Greece.
   [Falagas, M. E.] Mitera Hosp, Hygeia Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Falagas, M. E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, 9 Neapoleos St, Athens 15123, Greece.
EM m.falagas@aibs.gr
RI Mavros, Michail/AAS-3154-2020; Alexiou, Vangelis/GLR-9050-2022;
   /AAG-4461-2020
OI Mavros, Michail/0000-0003-2906-2005; Alexiou,
   Vangelis/0000-0003-1388-4880; 
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NR 46
TC 22
Z9 23
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0934-9723
EI 1435-4373
J9 EUR J CLIN MICROBIOL
JI Eur. J. Clin. Microbiol. Infect. Dis.
PD JUL
PY 2013
VL 32
IS 7
BP 851
EP 858
DI 10.1007/s10096-013-1830-z
PG 8
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA 163LX
UT WOS:000320338900002
PM 23380885
DA 2026-07-24
ER

PT J
AU Wang, GW
   Duan, GX
   Li, CK
   Tao, T
   Wang, KW
   Zong, CC
   Wang, ZY
AF Wang, Guowen
   Duan, Guixin
   Li, Chuankui
   Tao, Tao
   Wang, Kangwu
   Zong, Chengcheng
   Wang, Zuyi
TI Experiences in the diagnosis and treatment of postoperative
   esophagopleural sac fistula
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Esophagectomy; anastomotic fistula; esophageal cancer; esophageal
   perforation
ID INTRATHORACIC ANASTOMOTIC LEAK; VACUUM-ASSISTED CLOSURE; CONTRAST
   SWALLOW; ESOPHAGECTOMY; MANAGEMENT; STENT; CT; COMPLICATIONS; PLACEMENT;
   RESECTION
AB Esophagopleural sac fistula is a rare complication of esophagectomy associated with a relatively high mortality rate. To examine the diagnosis and treatment of esophago-mediastinal/pleural sac fistulas, 6 cases of esophago-mediastinal/pleural fistula of different etiologies, with a critical appraisal of current domestic and international clinical research, were analyzed. Our six patients were recovered and discharged from the hospital. Although contrast abdominal computed tomography, using a water-soluble contrast medium, and endoscopy can be used for the diagnosis of esophago-mediastinal/pleural sac fistulas in specific patients, observation of clinical symptoms remains the most important criterion for diagnosis. A standardized evaluation of specific issues is recommended for all patients to effectively determine the need for re-thoracotomy. Stent implantation under endoscopy should be avoided unless absolutely necessary. However, vacuum sealing and drainage of a transesophageal anastomotic stoma can facilitate healing of a leak. Pleural lavage can be used, when necessary, to relieve clinical symptoms and, again, facilitate healing of a leak. Moreover, maintaining intact pleura on the pleural cupula can reduce the risk of a cervical anastomotic fistula from spreading into the chest cavity.
C1 [Wang, Guowen; Duan, Guixin; Li, Chuankui; Tao, Tao; Wang, Kangwu; Zong, Chengcheng; Wang, Zuyi] Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Zhihuai Rd, Bengbu 233004, Anhui, Peoples R China.
C3 Bengbu Medical University
RP Wang, ZY (通讯作者)，Bengbu Med Coll, Dept Thorac Surg, Affiliated Hosp 1, 287 Zhihuai Rd, Bengbu 233004, Anhui, Peoples R China.
EM wgwpc1@126.com
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NR 54
TC 0
Z9 0
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 10
BP 8175
EP 8193
PG 19
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OL2QD
UT WOS:000585185700122
DA 2026-07-24
ER

PT J
AU Nicoli, F
   Balzani, A
   Lazzeri, D
   Gentile, P
   Chilgar, RM
   Di Pasquali, C
   Nicoli, M
   Bocchini, I
   Agovino, A
   Cervelli, V
AF Nicoli, Fabio
   Balzani, Alberto
   Lazzeri, Davide
   Gentile, Pietro
   Chilgar, Ram M.
   Di Pasquali, Camilla
   Nicoli, Marzia
   Bocchini, Ilaria
   Agovino, Annarita
   Cervelli, Valerio
TI Severe hidradenitis suppurativa treatment using platelet-rich plasma gel
   and Hyalomatrix
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Hidradenitis suppurativa; Hyalomatrix; Hyaluronic acid; Platelet-rich
   plasma; PRP gel
ID VACUUM-ASSISTED CLOSURE; HYALURONIC-ACID; MANAGEMENT; ANGIOGENESIS;
   CLINDAMYCIN; SURGERY; ACNE
AB Hidradenitis suppurativa (HS) can be a debilitating chronic disease. The underlying cause of the disease is still not clear. HS may be managed through numerous different medical or surgical procedures. Surgical treatment may consist of local excisions and reconstruction using a variety of methods: perforator flaps, skin grafts, local flaps, primary closure or secondary wound healing with vacuum and other devices. This report describes our experience with surgical excision and closure using platelet-rich plasma (PRP) gel and Hyalomatrix PA (HPA) in a patient with severe HS involving most of the body surface. We treated the patient with resection of severe HS of the nuchae and closure with PRP gel prepared with the RegenKit((R)) to promote neovascularisation and HPA, a delivery system for hyaluronic acid, to induce a neodermis at the wound bed and to stimulate regeneration in a humid and protected environment. Complete wound healing was achieved after 2 months. The obtained result proved the efficacy of this treatment without complications. No recurrence was observed during the 1 year after the surgical procedure. Severe HS can be safely and effectively managed with wide excision, PRP gel and Hyalomatrix to achieve a successful outcome.
C1 [Nicoli, Fabio; Balzani, Alberto; Gentile, Pietro; Di Pasquali, Camilla; Bocchini, Ilaria; Agovino, Annarita; Cervelli, Valerio] Policlin Casilino Univ Tor Vergata Rome, Dept Plast & Reconstruct Surg, I-00148 Rome, Italy.
   [Lazzeri, Davide] Hosp Pisa, Plast & Reconstruct Surg Unit, Pisa, Italy.
   [Chilgar, Ram M.] Maharashtra Univ Hlth Sci, Dept Plast & Reconstruct Surg, Nasik, India.
   [Nicoli, Marzia] Univ Roma La Sapienza, Dept Immunol, I-00185 Rome, Italy.
C3 Sapienza University Rome
RP Nicoli, F (通讯作者)，Policlin Casilino Univ Tor Vergata Rome, Dept Plast & Reconstruct Surg, Via Castelbarco 88, I-00148 Rome, Italy.
EM dr.fabionicoli@gmail.com
RI Nicoli, Fabio/AAG-2771-2020; gentile, pietro/HKE-5941-2023
OI Nicoli, Fabio/0000-0002-0809-5572; 
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
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NR 35
TC 71
Z9 73
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2015
VL 12
IS 3
BP 338
EP 343
DI 10.1111/iwj.12117
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CI1CA
UT WOS:000354476800020
PM 23834343
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Pan, SF
   Xiong, L
   Wang, ZJ
   Su, YJ
   Fang, GF
   Zhu, MD
   Wang, J
   Shi, HQ
   Zhu, SH
   Shi, YB
AF Pan, Sunfeng
   Xiong, Lie
   Wang, Zhenjun
   Su, Yujuan
   Fang, Gaofeng
   Zhu, Minda
   Wang, Jing
   Shi, Hanqiang
   Zhu, Shihui
   Shi, Yanbo
TI Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with
   Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; VEGF
AB Background. Negative pressure wound therapy (NPWT) with instillation (NPWTi) is a new treatment for chronic skin ulcers (CSUs), but the choice of perfusate is still investigated. The clinical application of Huoxue Shengji (HXSJ) decoction has been proved to promote the formation of granulation. The formation of fresh granulation, angiogenesis, and proliferation of vascular endothelial cells are closely related. The purpose of this study was to observe the clinical efficacy of NWPT with HXSJ decoction instillation in the treatment of CSUs and to explore the potential mechanism by which HXSJ decoction promotes proliferation of vascular endothelial cells at the cellular level. Methods. In the clinical study, the random number table was used to divide the patients into three groups (patients were numbered by visit time and assigned a random number and grouped by the remainder after the random number was divided by 3, and when the number of patients in one group reached 20, the enrolment of this group is stopped), including NPWT combined with HXSJ decoction instillation (group A), NPWT combined with normal saline instillation (group B), and NPWT (group C). Related indexes were examined, including the wound cavity volume, bacterial culture, histopathology examination, time periods of debridement, repair methods, and the time of ulcer healing. In the basic research, the effect of HXSJ decoction on the proliferation of HUVECs was analysed by CCK-8 assay and RT-PCR and western blot were used to quantify the VEGF and VEGFR-2 expression in the relevant signalling pathway. Results. There was no significant difference in the improvement rate of invasive cavity volume (P>0.05) between groups A and B, but a significant difference was observed between groups A and C (P<0.05). There was no significant difference in microbial reduction among groups (all P>0.05). Histopathological examination showed that the microvascular count in group A was significantly higher than that in groups B and C (both P<0.01) and there was no statistical difference between groups B and C (P>0.05). There were no significant differences in the number of invasive lesions and repair methods among the groups (all P>0.05). The healing time of group A was significantly faster than those of groups B and C (compared to group B, P<0.05; compared to group C, P<0.01), and there was no statistical difference between groups B and C (P>0.05). In the cellular experiments, concentration screening was performed and 125 mu g/mL HXSJ decoction showed the most significant effect on the proliferation of HUVECs and also enhanced the expression of VEGF and VEGFR-2. Conclusion. HXSJ decoction can enhance the expression of VEGF and VEGFR-2 and promote the proliferation of HUVECs. Treatment with NWPT with HXSJ decoction instillation can further reduce the wound cavity volume; meanwhile, it can promote blood vessel formation in ulcer wounds, thus accelerating the healing of CSUs.
C1 [Pan, Sunfeng; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing] Zhejiang Chinese Med Univ, Dept Burns & Plast Surg, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.
   [Pan, Sunfeng; Xiong, Lie; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing; Shi, Hanqiang; Shi, Yanbo] Jiaxing Key Lab Diabet Angiopathy Res, Jiaxing, Zhejiang, Peoples R China.
   [Pan, Sunfeng; Wang, Zhenjun; Su, Yujuan; Fang, Gaofeng; Zhu, Minda; Wang, Jing] Jiaxing Burn & Wound Repair Therapy Ctr, Jiaxing, Zhejiang, Peoples R China.
   [Xiong, Lie; Shi, Hanqiang; Shi, Yanbo] Zhejiang Chinese Med Univ, Cent Lab Mol Med Res Ctr, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.
   [Zhu, Shihui] Naval Med Univ, Changhai Hosp, Dept Burns Surg, Shanghai, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Naval Medical University
RP Shi, YB (通讯作者)，Jiaxing Key Lab Diabet Angiopathy Res, Jiaxing, Zhejiang, Peoples R China.; Shi, YB (通讯作者)，Zhejiang Chinese Med Univ, Cent Lab Mol Med Res Ctr, Jiaxing TCM Hosp, Jiaxing, Zhejiang, Peoples R China.; Zhu, SH (通讯作者)，Naval Med Univ, Changhai Hosp, Dept Burns Surg, Shanghai, Peoples R China.
EM doctorzhushihui@163.com; shiyanbocas@163.com
RI Xiong, Lie/HJI-5642-2023; Shi, Hanqiang/ODJ-9915-2025
FU Public Welfare Technology Applied Research Projects in Zhejiang Province
   [LGF21H270009]; Zhejiang Science and Technology Program of Traditional
   Chinese Medicine [2020ZB251, 2018ZB126]; Zhejiang Medical and Health
   Science and Technology Program [2019KY702]; Project of Science and
   Technology Innovation for People's livelihood of Jiaxing [2018AY32032]
FX THe authors thank the nursing department and related nursing staff that
   assisted us in the course of clinical research. -e authors thank Mr.
   Pufan Zhou for technical assistance. -is work was supported by the
   Public Welfare Technology Applied Research Projects in Zhejiang Province
   (LGF21H270009), Zhejiang Science and Technology Program of Traditional
   Chinese Medicine (2020ZB251), Zhejiang Medical and Health Science and
   Technology Program (2019KY702), Project of Science and Technology
   Innovation for People's livelihood of Jiaxing (2018AY32032), and
   Zhejiang Science and Technology Program of Traditional Chinese Medicine
   (2018ZB126).
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NR 29
TC 2
Z9 3
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 22
PY 2022
VL 2022
AR 5183809
DI 10.1155/2022/5183809
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3R1TC
UT WOS:000838701200004
PM 35783525
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Rocco, G
   Martucci, N
   La Rocca, A
   La Manna, C
   De Luca, G
   Fazioli, F
   Mori, S
AF Rocco, Gaetano
   Martucci, Nicola
   La Rocca, Antonello
   La Manna, Carmine
   De Luca, Giuseppe
   Fazioli, Flavio
   Mori, Stefano
TI Postoperative Local Morbidity and the Use of Vacuum-Assisted Closure
   After Complex Chest Wall Reconstructions With New and Conventional
   Materials
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID COMBINATION; RESECTION; BIOMATERIALS; INFECTION; RADIATION; IMPLANTS;
   SURGERY; DEFECTS; CANCER
AB Background. New materials (NM) such as titanium plates, cryopreserved grafts, and acellular collagen matrices are being increasingly used for chest wall reconstruction as a result of improved incorporation while maintaining structural stability and reduced need for removal from infected areas. Direct comparisons between NM and conventional materials (CM) in terms of local morbidity and need for prosthesis removal are lacking.
   Methods. Between January 2005 and July 2013, 109 procedures were performed to remove chest wall tumors in 86 patients. Of these, 32 underwent complex chest wall reconstructions owing to either recurrence, defect extension (greater than 3 ribs or >100 cm(2)) or local conditions (ie, previous irradiation or infection). New materials and CM (ie, polytetrafluoroethylene and methyl methacrylate) were used in 17 (53%) and 15 (47%) patients, respectively. Of the 32 patients included in the high complexity group, 23 patients did not exhibit any postoperative complications (72%). However, 9 patients (28%) underwent both a first and a second reoperation after a median interval of 4 months from the first procedure (range, 7 days to 60 months). Vacuum-assisted closure (VAC) was instituted in all patients as a means to control sepsis and facilitate space obliteration with healthy tissue.
   Results. In 7 patients the reason for reintervention was local wound complications. In 4 of 7 patients, the prosthesis had to be removed (3 CM and 1 NM, 4.6% of the whole series; 12.5% in the high complexity group, 5.9% for NM and 20% for CM). The median time to complete chest wall healing after VAC in patients with local sepsis was 14 months (range, 5 to 60 months). All patients are currently alive and well except for 1 who died 11 months after complete chest wall healing as a result of dissemination of metastatic chondrosarcoma. At univariate analysis, predictors of overall and grade 2 or less morbidity according to the Common Terminology Criteria for Adverse Events version 4.0 were first (p = 0.038) and second (p = 0.015) redo operations. Conversely, patients with a body mass index of less than 25 kg/m(2) (p = 0.049) undergoing one (p = 0.032) or two reconstructions (p = 0.00047) with combined materials (p = 0.00029) were more likely to experience local wound complications and require VAC. On multiple regression analysis, redo operations (first, p = 0.032; second, p = 0.00047) and the use of combined (synthetic and biologic) materials (p = 0.0029) were confirmed to be related to an increased incidence of wound complications.
   Conclusions. Multiple redo operations after complex chest wall reconstruction performed with a combination of NM and CM may be associated with an increased incidence of local wound complications. Nevertheless, in these cases, the use of NM and VAC yielded a low rate (5.8% versus 20% with CM) of prosthesis removal while achieving complete wound healing. (C) 2014 by The Society of Thoracic Surgeons
C1 IRCCS, Fdn Pascale, Ist Nazl Tumori, Div Thorac Surg,Sect Orthoped, Naples, Italy.
   IRCCS, Fdn Pascale, Ist Nazl Tumori, Serv Reconstruct Surg, Naples, Italy.
C3 IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale Tumori
   Milan; IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale
   Tumori Milan
RP Rocco, G (通讯作者)，Via Terminio 1, I-83028 Avellino, Italy.
EM gaetano.rocco@btopenworld.com
RI ; Rocco, Gaetano/K-4801-2016
OI INVERNIZZI, GIORGIO/0000-0002-0409-8127; Rocco,
   Gaetano/0000-0003-4150-8604; FAZIOLI, FLAVIO/0000-0002-4308-1192
CR [Anonymous], COMM TERM CRIT ADV E
   Arnold PG, 1996, PLAST RECONSTR SURG, V98, P804, DOI 10.1097/00006534-199610000-00008
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NR 21
TC 25
Z9 27
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUL
PY 2014
VL 98
IS 1
BP 291
EP 296
DI 10.1016/j.athoracsur.2014.04.022
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AK4ZF
UT WOS:000338432600072
PM 24857855
DA 2026-07-24
ER

PT J
AU Iheozor-Ejiofor, Z
   Newton, K
   Dumville, JC
   Costa, ML
   Norman, G
   Bruce, J
AF Iheozor-Ejiofor, Zipporah
   Newton, Katy
   Dumville, Jo C.
   Costa, Matthew L.
   Norman, Gill
   Bruce, Julie
TI Negative pressure wound therapy for open traumatic wounds
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SEVERE OPEN FRACTURES; COST-EFFECTIVENESS;
   MANAGEMENT; STANDARD; TRIAL; NPWT
AB Background
   Traumatic wounds (wounds caused by injury) range from abrasions and minor skin incisions or tears, to wounds with extensive tissue damage or loss as well as damage to bone and internal organs. Two key types of traumatic wounds considered in this review are those that damage soft tissue only and those that involve a broken bone, that is, open fractures. In some cases these wounds are left open and negative pressure wound therapy (NPWT) is used as a treatment. This medical device involves the application of a wound dressing through which negative pressure is applied and tissue fluid drawn away from the area. The treatment aims to support wound management, to prepare wounds for further surgery, to reduce the risk of infection and potentially to reduce time to healing (with or without surgical intervention). There are no systematic reviews assessing the effectiveness of NPWT for traumatic wounds.
   Objectives
   To assess the effects of NPWT for treating open traumatic wounds in people managed in any care setting.
   Search methods
   In June 2018 we searched the Cochrane Wounds Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE (including In-Process & Other Non-Indexed Citations), Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries for ongoing and unpublished studies, and scanned reference lists of relevant included studies as well as reviews, meta-analyses and health technology reports to identify additional studies. There were no restrictions with respect to language, date of publication or study setting.
   Selection criteria
   Published and unpublished randomised controlled trials that used NPWT for open traumatic wounds involving either open fractures or soft tissue wounds. Wound healing, wound infection and adverse events were our primary outcomes.
   Data collection and analysis
   Two review authors independently selected eligible studies, extracted data, carried out a 'Risk of bias' assessment and rated the certainty of the evidence. Data were presented and analysed separately for open fracture wounds and other open traumatic wounds (not involving a broken bone).
   Main results
   Seven RCTs (1377 participants recruited) met the inclusion criteria of this review. Study sample sizes ranged from 40 to 586 participants. One study had three arms, which were all included in the review. Six studies compared NPWT at 125 mmHg with standard care: one of these studies did not report any relevant outcome data. One further study compared NPWT at 75 mmHg with standard care and NPWT 125mmHg with NPWT 75 mmHg.
   Open fracture wounds (four studies all comparing NPWT 125 mmHg with standard care)
   One study (460 participants) comparing NPWT 125 mmHg with standard care reported the proportions of wounds healed in each arm. At six weeks there was no clear difference between groups in the number of participants with a healed, open fracture wound: risk ratio (RR) 1.01 (95% confidence interval (CI) 0.81 to 1.27); moderate-certainty evidence, downgraded for imprecision.
   We pooled data on wound infection from four studies (596 participants). Follow-up varied between studies but was approximately 30 days. On average, it is uncertain whether NPWT at 125 mmHg reduces the risk of wound infection compared with standard care (RR 0.48, 95% CI 0.20 to 1.13; I-2 = 56%); very low-certainty evidence downgraded for risk of bias, inconsistency and imprecision.
   Data from one study shows that there is probably no clear difference in health-related quality of life between participants treated with NPWT 125 mmHg and those treated with standard wound care (EQ-5D utility scores mean difference (MD) -0.01, 95% CI -0.08 to 0.06; 364 participants, moderate-certainty evidence; physical component summary score of the short-form 12 instrument MD -0.50, 95% CI -4.08 to 3.08; 329 participants; low-certainty evidence downgraded for imprecision).
   Moderate-certainty evidence from one trial (460 participants) suggests that NPWT is unlikely to be a cost-effective treatment for open fractures in the UK. On average, NPWT was more costly and conferred few additional quality-adjusted life years (QALYs) when compared with standard care. The incremental cost-effectiveness ratio was GBP 267,910 and NPWT was shown to be unlikely to be cost effective at a range of cost-per-QALYs thresholds. We downgraded the certainty of the evidence for imprecision.
   Other open traumatic wounds (two studies, one comparing NPWT 125 mmHg with standard care and a three-arm study comparing NPWT 125 mmHg, NPWT 75 mmHg and standard care)
   Pooled data from two studies (509 participants) suggests no clear difference in risk of wound infection between open traumatic wounds treated with NPWT at 125 mmHg or standard care (RR 0.61, 95% CI 0.31 to 1.18); low-certainty evidence downgraded for risk of bias and imprecision.
   One trial with 463 participants compared NPWT at 75 mmHg with standard care and with NPWT at 125 mmHg. Data on wound infection were reported for each comparison. It is uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and standard care (RR 0.44, 95% CI 0.17 to 1.10; 463 participants) and uncertain if there is a difference in risk of wound infection between NPWT 75 mmHg and 125 mmHg (RR 1.04, 95% CI 0.31 to 3.51; 251 participants. We downgraded the certainty of the evidence for risk of bias and imprecision.
   Authors' conclusions
   There is moderate-certainty evidence for no clear difference between NPWT and standard care on the proportion of wounds healed at six weeks for open fracture wounds. There is moderate-certainty evidence that NPWT is not a cost-effective treatment for open fracture wounds. Moderate-certainty evidence means that the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. It is uncertain whether there is a difference in risk of wound infection, adverse events, time to closure or coverage surgery, pain or health-related quality of life between NPWT and standard care for any type of open traumatic wound.
C1 [Iheozor-Ejiofor, Zipporah] Univ Cent Lancashire, Sch Med, Harrington Bldg, Preston, Lancs, England.
   [Newton, Katy] North Western Deanery, Gen Surg, Manchester, Lancs, England.
   [Dumville, Jo C.; Norman, Gill] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Nursing Midwifery & Social Work, Sch Hlth Sci,Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Costa, Matthew L.] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Bruce, Julie] Univ Warwick, Warwick Clin Trials Unit, Coventry, W Midlands, England.
C3 University of Lancashire; University of Manchester; University of
   Oxford; University of Warwick
RP Iheozor-Ejiofor, Z (通讯作者)，Univ Cent Lancashire, Sch Med, Harrington Bldg, Preston, Lancs, England.
EM ZIheozor-Ejiofor@uclan.ac.uk
RI iheozor-ejiofor, zipporah/N-3012-2013; Bruce, Julie/G-7588-2014; Norman,
   Gill/O-7029-2014; Dumville, Jo/O-7867-2014
OI iheozor-ejiofor, zipporah/0000-0003-2597-3266; Costa,
   Matthew/0000-0003-3644-1388; Bruce, Julie/0000-0002-8462-7999; Norman,
   Gill/0000-0002-3972-5733; Dumville, Jo/0000-0002-6546-3685
FU Division of Nursing Midwifery and Social Work, School of Health
   Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK; National Institute for Health Research (NIHR), UK; NIHR,
   via Cochrane Infrastructure and Cochrane Programme Grant funding (NIHR
   Cochrane Programme Grant) [13/89/08]; National Institute for Health
   Research Collaboration for Leadership in Applied Research and Care (NIHR
   CLAHRC), Greater Manchester, UK; NIHR CLAHRC Greater Manchester; NIHR
   Manchester Biomedical Research Centre, UK; NIHR Manchester Biomedical
   Research Centre; National Institute for Health Research [13/89/08]
   Funding Source: researchfish
FX Internal sourcesDivision of Nursing Midwifery and Social Work, School of
   Health Sciences, Faculty of Biology, Medicine and Health, University of
   Manchester, UK.External sourcesNational Institute for Health Research
   (NIHR), UK.This project was supported by the NIHR, via Cochrane
   Infrastructure and Cochrane Programme Grant funding (NIHR Cochrane
   Programme Grant 13/89/08- High Priority Cochrane Reviews in Wound
   Prevention and Treatment) to Cochrane Wounds. The views and opinions
   expressed therein are those of the authors and do not necessarily
   reflect those of the Systematic Reviews Programme, NIHR, NHS or the
   Department of Health, UK.National Institute for Health Research
   Collaboration for Leadership in Applied Research and Care (NIHR CLAHRC),
   Greater Manchester, UK.Jo Dumville was partly funded by the NIHR CLAHRC
   Greater Manchester. The funder had no role in the design of the studies,
   data collection and analysis, decision to publish, or preparation of the
   manuscript. However, the review may be considered to be affiliated to
   the work of the NIHR CLAHRC Greater Manchester. The views expressed
   herein are those of the authors and not necessarily those of the NHS,
   NIHR or the Department of Health.NIHR Manchester Biomedical Research
   Centre, UK.Jo Dumville and Gill Norman's work on this review was
   co-funded by the NIHR Manchester Biomedical Research Centre. The views
   expressed in this publication are those of the authors and not
   necessarily those of the NHS, the National Institute for Health Research
   or the Department of Health.NIHR Oxford Biomedical Research Centre,
   UK.Matthew Costa's work on this review was funded by the NIHR Oxford
   Biomedical Research Centre. The views expressed in this publication are
   those of the authors and not necessarily those of the NHS, the National
   Institute for Health Research or the Department of Health.
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NR 64
TC 61
Z9 69
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2018
IS 7
AR CD012522
DI 10.1002/14651858.CD012522.pub2
PG 71
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GO9HC
UT WOS:000440415900022
OA Green Published, Bronze
DA 2026-07-24
ER

PT J
AU Gunga, Z
   Rigollot, A
   Godat, A
   Niclauss, L
   Kirsch, M
AF Gunga, Ziyad
   Rigollot, Augustin
   Godat, Agnes
   Niclauss, Lars
   Kirsch, Matthias
TI First-in-Human Intramediastinal Taurolidine Irrigation for Candida
   albicans Mediastinitis After Biological Bentall Procedure
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE mediastinitis; taurolidine; <italic>Candida albicans</italic>; novel
   procedure; fungal infection; cardiac surgery
ID PREVENTION; MANAGEMENT; SURGERY; ASSOCIATION; INFECTIONS
AB Background: Post-sternotomy mediastinitis remains a devastating complication of cardiac surgery. Although most cases are bacterial, fungal mediastinitis due to Candida albicans is rare, aggressive, and particularly difficult to treat because of biofilm formation, prosthetic involvement, and limited penetration of systemic antifungal agents into infected tissues. Taurolidine is a taurine-derived antimicrobial compound with broad antibacterial, antifungal, and anti-biofilm properties that has shown promising results in catheter-related infection prevention and cardiac implantable electronic device surgery. Case summary: We report, to our knowledge, the first intramediastinal use of taurolidine for Candida albicans mediastinitis after biological Bentall surgery. Following urgent resternotomy and extensive debridement, 200 mL of taurolidine solution was instilled into the mediastinum for 60 min, then aspirated. Postoperatively, taurolidine irrigation via mediastinal drainage was combined with negative-pressure wound therapy and systemic antifungal treatment. Results: Rapid microbiological sterilization was achieved, inflammatory markers normalized, and follow-up computed tomography demonstrated complete resolution of mediastinal infection. Delayed sternal closure was then performed successfully without recurrence at 6-month follow up. Conclusion: To our knowledge, this represents the first reported use of intramediastinal taurolidine irrigation for fungal mediastinitis following cardiac surgery. Intramediastinal taurolidine irrigation may represent a promising adjunctive strategy for mediastinitis after cardiac surgery in high-risk patients. Further clinical evaluation is warranted.
C1 [Gunga, Ziyad; Rigollot, Augustin; Godat, Agnes; Niclauss, Lars; Kirsch, Matthias] Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Gunga, Z (通讯作者)，Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Dept Cardiovasc Surg, CH-1011 Lausanne, Switzerland.
EM ziyad.gunga@chuv.ch; agnes.godat@chuv.ch; lars.niclauss@chuv.ch;
   matthias.kirsch@chuv.ch
RI Gunga, Ziyad/PCT-2460-2025
OI Gunga, Ziyad/0009-0008-0276-2160
CR Abu-Omar Y, 2017, EUR J CARDIO-THORAC, V51, P10, DOI 10.1093/ejcts/ezw326
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   Radakovic S, 2020, ANTIBIOTICS-BASEL, V9, DOI 10.3390/antibiotics9040166
   Ramage G, 2006, FEMS YEAST RES, V6, P979, DOI 10.1111/j.1567-1364.2006.00117.x
   Schroeyers P, 2001, EUR J CARDIO-THORAC, V20, P743, DOI 10.1016/S1010-7940(01)00873-9
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   Vonthein R, 2024, J CARDIOTHORAC SURG, V19, DOI 10.1186/s13019-024-03059-1
NR 22
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD MAY 12
PY 2026
VL 13
IS 5
AR 204
DI 10.3390/jcdd13050204
EA MAY 2026
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IL8RA
UT WOS:001774763900001
PM 42188090
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jansen-Winkeln, B
   Niebisch, S
   Scheuermann, U
   Gockel, I
   Mehdorn, M
AF Jansen-Winkeln, Boris
   Niebisch, Stefan
   Scheuermann, Uwe
   Gockel, Ines
   Mehdorn, Matthias
TI Biomechanical Effects of Incisional Negative Wound Pressure Dressing: An
   Ex Vivo Model Using Human and Porcine Abdominal Walls
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID THERAPY
AB Introduction. Incisional negative pressure wound therapy (iNPWT) has been of recent interest in different surgical fields as beneficial outcomes on high-risk wounds have been reported. Nevertheless, its mechanisms of function are not widely studied to date. Methods. We established two ex vivo setups of iNPWT in porcine and human abdominal wall for measuring pressures within the wound which result from iNPWT application. For pressure measurements, a high-resolution manometry catheter and a balloon catheter probe were used in a wound sealed with either a commercially available PREVENA VAC kit or a self-made iNPWT kit. Furthermore, we evaluated seroma evacuation by iNPWT. Results. Both setups showed similar characteristics of pressure curves within the wound when applying increasing negative pressures. Application of high pressures did not result in a similar increase in wound pressure. Only subtotal evacuation of seroma by iNPWT application (about 75% of volume) could be detected. Conclusion. Our ex vivo model of iNPWT in porcine and human abdominal wall could show reproducible measurements of pressures within the wounds in both types of tissue. As intrawound pressures did not increase in the same way as the applied negative pressure, we suggest that our results do not advocate the idea of using iNPWT for wound care especially as seroma evacuation remains insufficient.
C1 [Jansen-Winkeln, Boris; Niebisch, Stefan; Scheuermann, Uwe; Gockel, Ines; Mehdorn, Matthias] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
C3 Leipzig University
RP Jansen-Winkeln, B (通讯作者)，Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
EM boris.jansen-winkeln@medizin.uni-leipzig.de;
   stefan.niebisch@medizin.uni-leipzig.de;
   uwe.scheuermann@medizin.uni-leipzig.de;
   ines.gockel@medizin.uni-leipzig.de;
   matthias.mehdorn@medizin.uni-leipzig.de
RI Jansen-Winkeln, Boris/KPA-5791-2024
OI Jansen-Winkeln, Boris/0000-0002-3996-9391
FU German Research Foundation (DFG); Universitat Leipzig
FX The authors express their gratitude to the body donor for donating the
   corpse for their research project after passing away. The authors also
   thank their families for supporting their valuable decision. They
   acknowledge support from the German Research Foundation (DFG) and
   Universitat Leipzig within the program of Open Access Publishing.
CR Borgquist O, 2011, WOUND REPAIR REGEN, V19, P727, DOI 10.1111/j.1524-475X.2011.00741.x
   Kairinos N, 2010, J PLAST RECONSTR AES, V63, P174, DOI 10.1016/j.bjps.2008.08.037
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Karlakki SL, 2016, BONE JOINT RES, V5, P328, DOI 10.1302/2046-3758.58.BJR-2016-0022.R1
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NR 10
TC 11
Z9 13
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 7058461
DI 10.1155/2018/7058461
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA HH5BD
UT WOS:000455739800001
PM 30687756
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lustig, A
   Alves, P
   Call, E
   Santamaria, N
   Gefen, A
AF Lustig, Adi
   Alves, Paulo
   Call, Evan
   Santamaria, Nick
   Gefen, Amit
TI The sorptivity and durability of gelling fibre dressings tested in a
   simulated sacral pressure ulcer system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE chronic wound; pressure injury; primary and secondary dressings; tissue
   phantom
ID PLASMA VISCOSITY; CHRONIC WOUNDS; SENSORS
AB Wound-dressing performances are affected by exudate viscosity, resistance to flow because of gravity, and bodyweight loads, the level of which is related to the body position. Here, we focussed on two dressing properties: (a) Sorptivity-the ability of dressings to transfer exudate away from the wound bed by capillary action-and (b) Durability-the capacity of dressings to maintain their integrity over time and during their removal. Both properties are critically important for avoiding further tissue damage but require the development of new laboratory tests for their measurement. A computer-controlled phantom of an exuding sacral pressure ulcer has therefore been developed and used to compare the performances of Exufiber (Molnlycke Health Care) vs an alternative market-leading dressing. Sorptivity was determined using weight tests, and durability was measured through tensile tests of the used dressings. For a supine configuration, the Exufiber dressing demonstrated similar to three times higher sorptivity and better durability, withstanding similar to five times greater strain energy than the other product before failure occurred. This work paves the way for quantitative, standardised testing of dressings in all aspects of exudate management. The reported tests are further suitable for testing dressing combinations or how dressings interact with negative pressure wound therapy.
C1 [Lustig, Adi; Gefen, Amit] Tel Aviv Univ, Dept Biomed Engn, Fac Engn, Tel Aviv, Israel.
   [Alves, Paulo] Catholic Univ Portugal, Ctr Interdisciplinary Res Hlth, Porto, Portugal.
   [Call, Evan] Weber State Univ, Dept Microbiol, Ogden, UT 84408 USA.
   [Santamaria, Nick] Univ Melbourne, Sch Hlth Sci, Melbourne, Vic, Australia.
C3 Tel Aviv University; Universidade Catolica Portuguesa; Utah System of
   Higher Education; Weber State University; University of Melbourne
RP Gefen, A (通讯作者)，Tel Aviv Univ, Dept Biomed Engn, Vasc Bioengn, Fac Engn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI ; Gefen, Amit/M-4720-2015; Alves, Paulo/AAD-1391-2019
OI Santamaria, Nick/0000-0001-5270-6943; Gefen, Amit/0000-0002-0223-7218;
   Alves, Paulo/0000-0002-6348-3316
FU Molnlycke Health Care
FX Molnlycke Health Care
CR Abdelrahman T., 2011, SURG OXFORD, V29, P491, DOI DOI 10.1016/J.MPSUR.2011.06.007
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NR 45
TC 30
Z9 31
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2021
VL 18
IS 2
BP 194
EP 208
DI 10.1111/iwj.13515
EA NOV 2020
PG 15
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA RC7KR
UT WOS:000591998400001
PM 33236856
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ge, S
   Ngaage, LM
   Orbay, H
   Silverman, RP
   Rasko, YM
   Rada, EM
AF Ge, Shealinne
   Ngaage, Ledibabari M.
   Orbay, Hakan
   Silverman, Ronald P.
   Rasko, Yvonne M.
   Rada, Erin M.
TI Surgical Management of Pediatric Hidradenitis Suppurativa A Case Series
   and Review of the Literature
SO ANNALS OF PLASTIC SURGERY
LA English
DT Review
DE hidradenitis suppurativa; surgical management; child; negative-pressure
   wound therapy; recurrence
ID RISK-FACTORS; RECURRENCE; OUTCOMES; CHILDREN; THERAPY
AB Background
   Hidradenitis suppurativa (HS) is a chronic and physically debilitating condition. Achieving long-term remission is difficult and sometimes remains elusive despite use of multiple pharmacological agents. However, surgery remains underused in the pediatric population.
   Methods
   We conducted a retrospective review for a 10-year period of all patients younger than 18 years who had undergone surgery for HS at a tertiary university hospital. In addition, we performed a literature review for English language articles related to the surgical management of pediatric HS patients.
   Results
   Eleven patients with a total of 23 operative sites were included in the study. The cohort was predominantly female (10:1) with an average age of 15.4 years and mean body mass index 31.9 kg/m(2). Lesion size ranged from 12.6 to 400 cm(2). Overall complication rate was 87% with a 7% reoperation rate to manage complications. Remission was achieved after a single procedure in 57% of sites. Three articles met our inclusion criteria for the literature review.
   Conclusions
   Our article adds to the sparse literature and represents the largest study on surgical management of pediatric HS patients. Although surgery is not without its challenges, it presents a safe option and for pediatric HS patients with extensive scar or sinus tract formation.
C1 [Ge, Shealinne; Ngaage, Ledibabari M.; Silverman, Ronald P.; Rasko, Yvonne M.; Rada, Erin M.] Univ Maryland, Sch Med, Div Plast Surg, 22 S Greene St, Baltimore, MD 21230 USA.
   [Ge, Shealinne; Ngaage, Ledibabari M.; Orbay, Hakan; Silverman, Ronald P.; Rasko, Yvonne M.; Rada, Erin M.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21230 USA.
   [Silverman, Ronald P.] Acel Corp, San Antonio, TX USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Rada, EM (通讯作者)，Univ Maryland, Sch Med, Div Plast Surg, 22 S Greene St, Baltimore, MD 21230 USA.
EM erada@som.umaryland.edu
RI ; Silverman, Ronald/A-5155-2018
OI Ngaage, Ledibabari/0000-0001-5802-779X; 
CR [Anonymous], 1998, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report
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NR 26
TC 14
Z9 16
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2020
VL 84
IS 5
BP 570
EP 574
DI 10.1097/SAP.0000000000002195
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LP5IU
UT WOS:000534352000020
PM 31913903
DA 2026-07-24
ER

PT J
AU Trost, JG
   Lin, LO
   Clark, SJ
   Khechoyan, DY
   Hollier, LH
   Buchanan, EP
AF Trost, Jeffrey G., Jr.
   Lin, Lawrence O.
   Clark, Sarah Jane
   Khechoyan, David Y.
   Hollier, Larry H., Jr.
   Buchanan, Edward P.
TI Separation of Thoraco-Omphalo-Ischiopagus Conjoined Twins: Surgical
   Planning, Management, and Outcomes
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID EXPERIENCE; EXPANSION
AB Background: Conjoined twins are a rare medical phenomenon that offers a unique challenge for medical professionals. The complex anatomy of conjoined twins dictates their survival and amenability to separation, making each case different in terms of medical management, surgical planning, and patient outcomes. Thoraco-omphalo-ischiopagus twins, joined from the thorax to the pelvis, are one of the rarest orientations recorded in the medical literature, and successful separation of this subset of conjoined twins has not been documented. This report presents a novel case of thoraco-omphalo-ischiopagus tetrapus twins who were successfully separated at 10 months of age. The pre-operative planning, operative details, and postoperative course are discussed as they relate to the reconstructive effort.
   Methods: Three-dimensional medical modeling was pursued early in the planning process and was used to estimate the soft-tissue requirements for reconstruction and to design custom tissue expanders.
   Results: The reconstructive effort required postponement until respiratory status was optimized. Even with elaborate preoperative planning, primary closure of the abdomen was limited because of tissue edema and other less predictable patient factors. Delayed closure of the abdominal wall was made possible with negative-pressure wound therapy and secondary flap advancements.
   Conclusion: Preoperative coordination with necessary vendors, a multidisciplinary surgical effort, and optimal timing of the surgical intervention all contribute to the successful separation and long-term survival of thoraco-omphalo-ischiopagus conjoined twins.
C1 Texas Childrens Hosp, Div Plast Surg, Houston, TX 77030 USA.
   Baylor Coll Med, Michael E Debakey Dept Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; Baylor
   College of Medicine
RP Buchanan, EP (通讯作者)，6701 Fannin St,CC 610-00, Houston, TX 77030 USA.
EM ebuchana@bcm.edu
RI ; Buchanan, Edward/K-1598-2019
OI Commander, Sarah/0000-0002-0985-9204; 
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NR 16
TC 13
Z9 14
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2016
VL 138
IS 5
BP 1064
EP 1072
DI 10.1097/PRS.0000000000002660
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ED7HM
UT WOS:000389033400054
PM 27783004
DA 2026-07-24
ER

PT J
AU Gao, M
   Zhang, XX
   Jian, TZ
   Sun, CC
   Yu, GC
   Gao, YK
   Kan, BT
   Jian, XD
AF Gao, Ming
   Zhang, Xiangxing
   Jian, Tianzi
   Sun, Cece
   Yu, Guangcai
   Gao, Yikai
   Kan, Baotian
   Jian, Xiangdong
TI Medical management of a child treated for two unique envenomation
   episodes via captive snakes in a 60-day period: A case report
SO HELIYON
LA English
DT Article
DE Snake bite; Bungarus multicinctus; Gloydius brevicaudus; Antivenom;
   Necrosis
ID ANTIVENOM; BITES
AB Venomous snake bites can result in irreversible damage, leading to respiratory dysfunction, bleeding disorders, kidney damage, or serious complications. In recent years, with the popularity of online shopping in China, snakes can be easily purchased and kept as pets, even if some areas are not natural habitats for certain kinds of snakes. A 13-year-old boy purchased two venomous snakes online as pets. On April 16, 2019,the boy was bitten by a B. multicinctus(Bungarus multicinctus), and he had mild difficulty breathing and limb weakness. He was discharged after symptomatic treatment with B. multicinctus antivenom. On June 17, 2019, the boy was bitten a second time by a short-tailed pit viper (Gloydius brevicaudus) resulting in swelling and necrosis of the left hand. After a systemic and comprehensive treatment was implemented, including Agkistrodon halys antivenom injections, infection control, hormone therapy, improved circulation, negative pressure wound therapy, skin graft, and nutritional support, the boy recovered. This case provides valuable insights for diagnosing and treating venomous snake bites and their complications while also raising public awareness about the hazards of purchasing venomous snakes online,and it also provide case support for the improvement of online shopping for minors, wildlife protection, and live animal mailing management, helping to prevent such incidents from happening again.
C1 [Gao, Ming; Sun, Cece; Yu, Guangcai; Gao, Yikai; Jian, Xiangdong] Shandong Univ, Cheeloo Coll Med, Dept Poisoning & Occupat Dis Emergency Med, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
   [Gao, Ming] Peking Univ Third Hosp, Dept Emergency Med, Beijing, Peoples R China.
   [Zhang, Xiangxing; Jian, Xiangdong] Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Dept Occupat & Environm Hlth, Jinan 250012, Shandong, Peoples R China.
   [Jian, Tianzi] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Hematol, Jinan 250012, Shandong, Peoples R China.
   [Kan, Baotian] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Nursing, Jinan 250012, Shandong, Peoples R China.
   [Jian, Xiangdong] Shandong Univ, Dept Poisoning & Occupat Dis, Emergency Med, Qilu Hosp, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
   [Kan, Baotian] Shandong Univ, Qilu Hosp, Dept Geriatr Med, Cheeloo Coll Med, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University; Shandong
   University; Shandong University; Shandong University
RP Jian, XD (通讯作者)，Shandong Univ, Dept Poisoning & Occupat Dis, Emergency Med, Qilu Hosp, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.; Kan, BT (通讯作者)，Shandong Univ, Qilu Hosp, Dept Geriatr Med, Cheeloo Coll Med, 107 Rd Wenhuaxi, Jinan 250012, Shandong, Peoples R China.
EM kanbaotian@163.com; jianxiangdongvip@vip163.com
RI Jian, Tianzi/KIB-4716-2024; Yu, Guangcai/KIJ-5983-2024
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NR 27
TC 1
Z9 1
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV 30
PY 2024
VL 10
IS 22
AR e40245
DI 10.1016/j.heliyon.2024.e40245
EA NOV 2024
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IB7JD
UT WOS:001767896800001
PM 39748992
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Schessel, ES
   Ger, R
   Oddsen, R
AF Schessel, Eli S.
   Ger, Ralph
   Oddsen, Robert
TI The Costs and Outcomes of Treating a Deep Pressure Ulcer in a Patient
   with Quadriplegia
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE pressure ulcer; quadriplegia; ischial; external tissue expanders
ID PREVENTION
AB The cost of pressure ulcers, especially Stage III and Stage IV ulcers, is substantial. A 27-year-old man with a 6-year history of quadriplegia developed an ischial pressure ulcer. Twelve months of treatment with wet-to-dry dressings were followed by admission to several facilities and 15 months of care with biological dressings and negative pressure wound therapy (NPWT). When admitted to the authors' wound care center, the wound measured 4.5 cm x 3.2 cm with exposed bone. A review of his insurance records showed that paid claims totaled $242,350, including $52,992 for NPWT rental costs. The patient was considered a good candidate for minimally invasive surgical intervention with external tissue expanders. Following a 14-day course of antibiotics to treat his infection, the wound was debrided and the tissue expanders applied. After 16 days, the wound was closed. The patient returned to work 6 weeks after the procedure. At the 23-month follow-up, the wound remained closed. Insurance payments for the care that resulted in wound closure totaled $43,814. This case study illustrates the potential of the external tissue expansion technique to close deep pressure ulcers within a relatively short amount of time at comparatively lower cost. Studies including control treatments are needed to confirm these conclusions.
C1 [Schessel, Eli S.] Flushing Hosp Med Ctr, Div Plast Surg, Flushing, NY USA.
RP Schessel, ES (通讯作者)，108-33 70th Rd,Forest Hills, New York, NY USA.
EM WoodWest3@aol.com
CR *AHCPR, AHCPR PUBL
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NR 18
TC 9
Z9 12
U1 1
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD FEB
PY 2012
VL 58
IS 2
BP 41
EP 46
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA 901LL
UT WOS:000300968300007
PM 22316632
DA 2026-07-24
ER

PT J
AU Kong, CG
   Park, JB
AF Kong, Chae-Gwan
   Park, Jong-Beom
TI Postoperative Infection After Esophageal Injury in Anterior Cervical
   Spine Surgery: A Comprehensive Review of Diagnosis, Management, and
   Outcomes
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE postoperative complications; esophageal injury; cervical spine
   infection; surgical management; infection control; rehabilitation
ID STERNOCLEIDOMASTOID MUSCLE FLAP; PERFORATION; REPAIR; FUSION; CEMENT
AB Postoperative infection following anterior cervical spine surgery, particularly when complicated by esophageal injury, is a rare but serious condition associated with significant morbidity and mortality. This review elucidates the complex interplay between postoperative infection and esophageal injury. We systematically analyzed studies from 2000 to 2025 using PubMed, Scopus, and Web of Science, focusing on infection, esophageal injury, surgical outcomes, and management strategies, with emphasis on recent advances in diagnostics, surgical techniques, and postoperative care. Our findings highlight the multifactorial nature of these complications and the critical role of early recognition, accurate diagnosis, and timely management. Imaging modalities such as CT, MRI, and contrast esophagography, along with flexible esophagoscopy, are indispensable in assessing injury and infection extent. Effective management requires a multidisciplinary approach integrating broad-spectrum antibiotics, surgical debridement, vascularized flap reinforcement, negative pressure wound therapy, and antibiotic-loaded cement beads. Meticulous postoperative care with prolonged antibiotics, nutritional support, and imaging follow-up is vital for optimizing outcomes. Innovative approaches, including vascularized muscle flaps and hyperbaric oxygen therapy, show promise in enhancing healing and reducing infections. Our review underscores the need for future meta-analyses to strengthen evidence and refine protocols. As surgical techniques evolve, so too must our diagnostic, surgical, and postoperative strategies to minimize complications and improve patient outcomes.
C1 [Kong, Chae-Gwan; Park, Jong-Beom] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Orthopaed Surg, Coll Med, Uijongbu 11765, South Korea.
C3 Catholic University of Korea
RP Park, JB (通讯作者)，Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Orthopaed Surg, Coll Med, Uijongbu 11765, South Korea.
EM gongjae@catholic.ac.kr; spinepjb@catholic.ac.kr
OI Park, Jong-Beom/0000-0001-8273-3731; Kong, Chae-gwan/0000-0003-4237-4556
CR Alhashash M, 2023, ARCH ORTHOP TRAUM SU, V143, P717, DOI 10.1007/s00402-021-04133-2
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NR 36
TC 4
Z9 5
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 7
PY 2025
VL 14
IS 9
AR 3244
DI 10.3390/jcm14093244
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2MZ8B
UT WOS:001486517200001
PM 40364274
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Insausti, CL
   Alcaraz, A
   García-Vizcaíno, EM
   Mrowiec, A
   López-Martínez, MC
   Blanquer, M
   Piñero, A
   Majado, MJ
   Moraleda, JM
   Castellanos, G
   Nicolás, FJ
AF Insausti, Carmen L.
   Alcaraz, Antonia
   Garcia-Vizcaino, Eva M.
   Mrowiec, Anna
   Lopez-Martinez, Maria C.
   Blanquer, Miguel
   Pinero, Antonio
   Majado, Maria J.
   Moraleda, Jose M.
   Castellanos, Gregorio
   Nicolas, Francisco J.
TI Amniotic membrane induces epithelialization in massive posttraumatic
   wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID STEM-CELLS; TERM PLACENTA; C-JUN; TRANSPLANTATION; SKIN; EXPRESSION;
   AP-1; DIFFERENTIATION; ACTIVATION; ULCERS
AB Large-surface or deep wounds often become senescent in the inflammatory or proliferation stages and cannot progress to reepithelialization. This failure makes intervention necessary to provide the final sealing epithelial layer. The best current treatment is autologous skin graft, although there are other choices such as allogenic or autologous skin substitutes and synthetic dressings. Amniotic membrane (AM) is a tissue of interest as a biological dressing due to its biological properties and immunologic characteristics. It has low immunogenicity and beneficial reepithelialization effects, with antiinflammatory, antifibrotic, antimicrobial, and nontumorigenic properties. These properties are related to its capacity to synthesize and release cytokines and growth factors. We report the use of AM as a wound dressing in two patients with large and deep traumatic wounds. Negative pressure wound therapy followed by AM application was capable of restoring skin integrity avoiding the need for skin graft reconstruction. AM induced the formation of a well-structured epidermis. To understand this effect, we designed some assays on human keratinocyte-derived HaCaT cells. AM treatment of HaCaT induced ERK1/2 and SAP/JNK kinases phosphorylation and c-jun expression, a gene critical for keratinocytes migration; however, it did not affect cell cycle distribution. These data suggest that AM substantially modifies the behavior of keratinocytes in chronic wounds, thereby allowing effective reepithelialization.
C1 [Alcaraz, Antonia; Garcia-Vizcaino, Eva M.; Mrowiec, Anna; Lopez-Martinez, Maria C.; Nicolas, Francisco J.] Hosp Univ Virgen Arrixaca, Unidad Invest, Oncol Mol & TGF, Murcia 30120, Spain.
   [Pinero, Antonio; Castellanos, Gregorio] Hosp Univ Virgen Arrixaca, Serv Cirugia, Murcia, Spain.
   [Insausti, Carmen L.; Blanquer, Miguel; Majado, Maria J.; Moraleda, Jose M.] Hosp Univ Virgen Arrixaca, Unidad Terapia Celular, Murcia, Spain.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; Hospital Clinico
   Universitario Virgen de la Arrixaca; Hospital Clinico Universitario
   Virgen de la Arrixaca
RP Nicolás, FJ (通讯作者)，Hosp Univ Virgen Arrixaca, Unidad Invest, Oncol Mol & TGF, Crta Madrid Cartagena S-N, Murcia 30120, Spain.
EM franciscoj.nicolas2@carm.es
RI Blanquer Blanquer, Miguel/B-8732-2008; Nicolás, Francisco
   José/H-9422-2019; Moraleda, Jose M/AAB-4119-2020; López-Martínez,
   Carlos/J-7446-2012; Piñero-Madrona, Antonio/AAB-5138-2022
OI Blanquer Blanquer, Miguel/0000-0002-1471-8828; Nicolás, Francisco
   José/0000-0002-3969-1430; Moraleda, Jose M/0000-0001-9080-1466;
   López-Martínez, Carlos/0000-0002-1366-9446; Mrowiec,
   Anna/0000-0001-8745-5494; Piñero-Madrona, Antonio/0000-0002-7718-8318
FU Spanish Ministry of Education and Science; Fundacion Seneca de la Region
   de Murcia; Instituto de Salud Carlos III; Fondo de Investigaciones
   Sanitarias; Hospital Universitario Virgen de la Arrixaca
FX This work was supported by a grant from the Spanish Ministry of
   Education and Science, a grant from the Fundacion Seneca de la Region de
   Murcia, and a grant from the Instituto de Salud Carlos III, Fondo de
   Investigaciones Sanitarias. E.M.G.V. was supported by a student grant
   from de Fundacion Seneca de la Region de Murcia. F.J.N. was supported by
   the Ramon y Cajal program of the Spanish Ministry for Education and
   Science. We are indebted to the Hospital Universitario Virgen de la
   Arrixaca, which strongly supported this research.
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NR 36
TC 74
Z9 82
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2010
VL 18
IS 4
BP 368
EP 377
DI 10.1111/j.1524-475X.2010.00604.x
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 619UB
UT WOS:000279454700077
PM 20636551
DA 2026-07-24
ER

PT J
AU Fligor, CW
   Duplechain, AB
   Chaffin, AE
AF Fligor, Caleb W.
   Duplechain, Abby B.
   Chaffin, Abigail E.
TI A 12-Month Retrospective Review of Pressure Injury Plastic Surgical Flap
   Techniques Utilizing Pure Hypochlorous Acid (pHA) Preserved Wound
   Solution for Wound Bed Preparation
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Pressure Ulcer; Surgical Flaps; Surgical Wound; Therapeutic Irrigation;
   Wound Infection
ID RECONSTRUCTION; EXPERIENCE; SURFACE; COST
AB Background: The presence of heavy microbial colony formation, polymicrobial infection, and local altered pH contribute to the high rate of postoperative complications following surgical reconstruction of stage IV pressure injuries (PIs). Purpose: The objective of this study was to determine the rate of bacteria-related postoperative complications following surgical reconstruction of stage IV PIs in which a pure hypochlorous acid (pHA) antimicrobially preserved wound cleaning solution was used. Methods: This 1-year retrospective review evaluated the outcomes of patients who underwent surgical reconstructive treatment of chronic stage IV PI. Surgical management consisted of wide debridement, intraoperative cultures, and irrigation with 8 to 10 minutes indwelling of a pHA antimicrobially preserved wound cleaning solution prior to closure and application of incisional negative pressure wound therapy (iNPWT). Results: Thirteen patients (18 chronic, stage IV PIs) were included in the study. Intraoperative cultures were positive for 10/18 wounds (55.6%). A bacteria- related postoperative complication occurred in 1 patient (1/13, 7.7%; postoperative dehiscence requiring reoperation). Conclusions: Adjunctive irrigation and indwelling of a pHA antimicrobially preserved wound cleansing solution in the surgical management of chronic, stage IV PIs in this 1-year retrospective review resulted in a 7.7% bacteria-related postoperative complication rate.
C1 [Fligor, Caleb W.] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70118 USA.
   [Duplechain, Abby B.] Tulane Univ, Sch Med, New Orleans, LA USA.
   [Chaffin, Abigail E.] Tulane Univ, Sch Med, Div Plast & Reconstruct Surg, New Orleans, LA USA.
C3 Tulane University; Tulane University; Tulane University
RP Fligor, CW (通讯作者)，Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70118 USA.
FU Urgo North America
FX Funding: Urgo North America provided financial support to Valerie
   Marmolejo, DPM, MS, MWC, with Scriptum Medica, for assistance in
   preparation of this manuscript.
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NR 36
TC 0
Z9 0
U1 1
U2 2
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD DEC
PY 2024
VL 70
IS 4
AR 24001
DI 10.25270/wmp.24001
PG 9
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA S7J5R
UT WOS:001399939300006
PM 39788876
DA 2026-07-24
ER

PT J
AU Rampi, A
   Comini, LV
   Galli, A
   Howardson, BO
   Tettamanti, A
   Luparello, P
   Redaelli, G
   Di Santo, D
   Bondi, S
AF Rampi, Andrea
   Comini, Lara Valentina
   Galli, Andrea
   Howardson, Bright Oworae
   Tettamanti, Alberto
   Luparello, Paolo
   Redaelli, Gabriele
   Di Santo, Davide
   Bondi, Stefano
TI Reconstructive Surgery of the Head and Neck in Organ Transplant
   Recipients: A Case Report and a Review of the Literature
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE head and neck surgery; solid organ recipients; wound healing;
   immunosuppressive agents; reconstructive flaps
ID WOUND-HEALING COMPLICATIONS; KIDNEY-TRANSPLANTATION;
   LIVER-TRANSPLANTATION; CANCER INCIDENCE; RISK; IMMUNOSUPPRESSION;
   TACROLIMUS; COHORT
AB The number of solid organ transplant recipients (SOTRs) is growing as a consequence of an increase in transplantations and longer survival; these patients, thus, frequently suffer various comorbidities and are subjected to the detrimental effects of immunosuppressive agents, which expose them to a higher risk of developing malignancies. These drugs also complicate the surgical treatment of neoplasms, as they can hinder wound healing, especially when associated with other unfavorable factors (e.g., previous radiotherapy, diabetes, etc.). We herein present our experience with a 74-year-old SOTR who underwent a radical extended parotidectomy and reconstruction with a submental island flap for a persistent cutaneous squamous carcinoma after radiotherapy; his complicated clinical course was characterized by incredibly slow wound healing. The current literature was reviewed to provide a succinct overview of the main difficulties of head and neck surgery in SOTRs. In particular, the immunosuppressive regimen can be tapered considering the individual risk and other elements should be carefully assessed, possibly prior to surgery, to prevent cumulative harm. New developments, including intraoperative monitoring of flap vascularization through indocyanine green fluorescence video-angiography and the prophylactic application of negative pressure wound therapy, when feasible, may be particularly beneficial for high-risk patients.
C1 [Rampi, Andrea; Redaelli, Gabriele] Sondrio Hosp, Otorhinolaryngol Unit, ASST Valtellina & Alto Lario, I-23100 Sondrio, Italy.
   [Comini, Lara Valentina; Luparello, Paolo; Di Santo, Davide; Bondi, Stefano] FPO IRCCS, Candiolo Canc Inst, Otorhinolaryngol Head & Neck Surg, I-10060 Turin, Italy.
   [Galli, Andrea; Howardson, Bright Oworae; Tettamanti, Alberto] IRCCS San Raffaele Sci Inst, Div Head & Neck Dept, Otorhinolaryngol Unit, I-20132 Milan, Italy.
   [Galli, Andrea; Howardson, Bright Oworae; Tettamanti, Alberto] Univ Vita Salute San Raffaele, Sch Med, I-20132 Milan, Italy.
C3 IRCCS Fondazione del Piemonte per l'Oncologia; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele
   University
RP Galli, A (通讯作者)，IRCCS San Raffaele Sci Inst, Div Head & Neck Dept, Otorhinolaryngol Unit, I-20132 Milan, Italy.; Galli, A (通讯作者)，Univ Vita Salute San Raffaele, Sch Med, I-20132 Milan, Italy.
EM galli1.andrea@hsr.it; stefano.bondi@ircc.it
RI Galli, Andrea/I-4821-2019; Di Santo, Davide/AAN-6965-2020; Comini, Lara
   Valentina/KOC-1450-2024
OI Galli, Andrea/0000-0003-2677-8091; Tettamanti,
   Alberto/0009-0009-7260-9126; Bondi, Stefano/0000-0002-9163-5540; Di
   Santo, Davide/0000-0002-8239-3850; Comini, Lara
   Valentina/0000-0002-3639-1504
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NR 42
TC 2
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2024
VL 13
IS 16
AR 4790
DI 10.3390/jcm13164790
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA E7O0U
UT WOS:001304850400001
PM 39200933
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Everett, E
   Mathioudakis, N
AF Everett, Estelle
   Mathioudakis, Nestoras
TI Update on management of diabetic foot ulcers
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE diabetes; diabetic foot ulcers; wound healing; diabetic foot management
ID ACELLULAR DERMAL MATRIX; PERIPHERAL ARTERIAL-DISEASE; AMNIOTIC MEMBRANE
   ALLOGRAFT; LOWER-EXTREMITY AMPUTATIONS; EPIDERMAL-GROWTH-FACTOR;
   PLATELET-RICH PLASMA; LEVEL LASER THERAPY; DOUBLE-BLIND;
   MULTIDISCIPLINARY TEAM; HYPERBARIC-OXYGEN
AB Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic. Even with this comprehensive approach, there is still room for improvement in DFU outcomes. Several adjuvant therapies have been studied to reduce DFU healing times and amputation rates. We reviewed the rationale and guidelines for current standard of care practices and reviewed the evidence for the efficacy of adjuvant agents. The adjuvant therapies reviewed include the following categories: nonsurgical debridement agents, dressings and topical agents, oxygen therapies, negative pressure wound therapy, acellular bioproducts, human growth factors, energy-based therapies, and systemic therapies. Many of these agents have been found to be beneficial in improving wound healing rates, although a large proportion of the data are small, randomized controlled trials with high risks of bias.
C1 [Everett, Estelle; Mathioudakis, Nestoras] Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 East Monument St,Suite 333, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Mathioudakis, N (通讯作者)，Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 East Monument St,Suite 333, Baltimore, MD 21205 USA.
EM nmathio1@jhmi.edu
RI Mathioudakis, Nestoras/AAP-4595-2020; Everett, Estelle/JXN-1795-2024
OI Mathioudakis, Nestoras/0000-0002-0210-655X; Everett,
   Estelle/0000-0002-7468-296X
FU NIDDK NIH HHS [R01 DK115648, T32 DK062707] Funding Source: Medline;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [T32DK062707] Funding Source: NIH RePORTER
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NR 102
TC 671
Z9 819
U1 19
U2 376
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JAN
PY 2018
VL 1411
IS 1
SI SI
BP 153
EP 165
DI 10.1111/nyas.13569
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FU0PE
UT WOS:000423552000011
PM 29377202
OA Green Submitted
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Dalla Paola, L
   Carone, A
   Boscarino, G
   Scavone, G
   Vasilache, L
AF Dalla Paola, Luca
   Carone, Anna
   Boscarino, Giulio
   Scavone, Giuseppe
   Vasilache, Lucian
TI Combination of Open Subtotal Calcanectomy and Stabilization With
   External Fixation as Limb Salvage Procedure in Hindfoot-Infected
   Diabetic Foot Ulcers
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetic foot ulcer; osteomyelitis; foot infection; diabetic foot
   surgery
ID HEEL; OSTEOMYELITIS; ULCERATIONS; AMPUTATION; ALGORITHM
AB Diabetic hindfoot ulcers, complicated by osteomyelitis, are associated with a high risk of major amputation. Partial calcanectomy, preceded by an effective management of the infection and of the eventual peripheral artery disease, can be considered as valid therapeutic option. We have evaluated a therapeutic protocol for diabetic hindfoot ulcers complicated by osteomyelitis, which, besides an adequate surgical debridement, considers a reconstructive pathway assisted by the positioning of a circular external fixator. We made a prospective study of a cohort of diabetic patients affected by heel ulcer complicated by osteomyelitis. All patients underwent open partial calcanectomy associated with the positioning of a circular external frame specifically designed for hindfoot stabilization and offloading. A reconstructive procedure was implemented starting with the application of negative pressure wound therapy and coverage with dermal substitute and split thickness skin grafting. From November 2014 to November 2015, 18 consecutive patients were enrolled. Mean follow-up period was 212.3 +/- 64.0 days. Healing was achieved in 18 (100%) patients. The mean healing time was 69.0 +/- 64.0 days. No major amputation had to be performed during the follow-up. Open partial calcanectomy associated with external fixation and skin reconstruction was as efficient as limb salvage in patients with infected lesions of the hindfoot complicated by calcaneal osteomyelitis.
C1 [Dalla Paola, Luca; Carone, Anna; Boscarino, Giulio; Scavone, Giuseppe; Vasilache, Lucian] Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy.
C3 Maria Cecilia Hospital
RP Dalla Paola, L (通讯作者)，Maria Cecilia Hosp, Diabet Foot Dept, GVM Care & Res, Via Corriera 1, I-48010 Cotignola, RA, Italy.
EM ldallapaola@libero.it
CR Attinger C., 2011, AM COLL WOUND HEAL T
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NR 42
TC 16
Z9 18
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2016
VL 15
IS 4
BP 332
EP 337
DI 10.1177/1534734616667865
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0FF
UT WOS:000392883300008
PM 27694302
DA 2026-07-24
ER

PT J
AU von Beckerath, O
   Kanya, S
   Gäbel, G
   Kröger, K
   Juntermanns, B
AF von Beckerath, Olga
   Kanya, Susanne
   Gaebel, Gabor
   Kroeger, Knut
   Juntermanns, Benjamin
TI Use of maggot debridement therapy in hospitalised patients in Germany
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE debridement; foot ulcer; infection; maggots
ID EFFICACY; MULTICENTER; QUALITY; ULCERS; FOOT
AB Exact data regarding the clinical role of maggot debridement therapy (MDT) for wound care in a specific country are not available. Thus, we analysed the use of MDT in hospitalised patients in Germany. Detailed lists of all hospitalised cases treated with MDT in Germany for the years 2011 to 2016 were provided by the Federal Statistical Office as well as the lists of the 15 most frequent principal and additional diagnoses, respectively, and the 10 most frequent procedures documented with MDT in 2016. Within the 6-year time period of the study, the number of cases treated with MDT increased by 11% from 4513 in 2011 to 5.017 in 2016. Lower leg and foot were the most frequent anatomic sides of treatment counting up to 83.9% of all cases. In addition, MDT procedures for temporary soft tissue coverage including negative pressure wound therapy were often performed: for treatment of large areas in 36.7% and small areas in 6.2%. 41.3% of all cases treated with MDT had infection with Escherichia coli and 35.9% of all cases with Bacillus fragilis. Our analysis shows a limited use of MDT with a small increase only in the last 6 years in German hospitals. MDT is predominately used to treat foot or leg ulcers.
C1 [von Beckerath, Olga; Gaebel, Gabor; Kroeger, Knut; Juntermanns, Benjamin] Helios Klin Krefeld, Dept Vasc Med, Krefeld, Germany.
   [Kanya, Susanne] Wound Healing, Krefeld, Germany.
C3 Helios Kliniken
RP Kröger, K (通讯作者)，HELIOS Klinikum Krefeld GmbH, Klin Gefassmed, Lutherpl 40, D-47805 Krefeld, Germany.
EM knut.kroeger@helios-kliniken.de
CR [Anonymous], 2010, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD003556.PUB2
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   Malekian A, 2019, J WOUND OSTOMY CONT, V46, P25, DOI 10.1097/WON.0000000000000496
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   Zarchi K, 2012, INT WOUND J, V9, P469, DOI 10.1111/j.1742-481X.2011.00919.x
NR 17
TC 8
Z9 9
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2020
VL 17
IS 1
BP 10
EP 15
DI 10.1111/iwj.13204
EA NOV 2019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KC9VQ
UT WOS:000493722500001
PM 31680434
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kakar, J
AF Kakar, Jayesh
TI Multimodality Treatment for Nonhealing Wound With Osteomyelitis in
   Sickle Cell Disease
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Letter
DE sickle cell disease; osteomyelitis; leg ulcer; hyperbaric oxygen therapy
   (HBOT)
AB We treated a 25-year-old male sickle cell disease (SCD) patient with a long-standing wound of the lower limb with radiologically confirmed osteomyelitis of the tibia, successfully managed by multimodality treatment. Culture of the wound after sequestrectomy revealed a Staphylococcus aureus infection, which was treated with appropriate antibiotics as per culture and sensitivity results. The patient had been under treatment for the same since 3 years in his home country with no improvement. He had a history of a leg ulcer due to injury and as is common in SCD patients, the ulcer led to bone infection. He had taken long courses of antibiotics and surgical drainage of pus, which are the usual treatment modalities used in such patients, with extended periods to healing and long durations of pain and tenderness. In this case systemic antibiotics were used only for 7 days. Low-molecular-weight heparin and dextran, negative pressure wound therapy coupled with nano silver dressings and hyperbaric oxygen treatment for 15 days led to the patient being pain free within 10 days of instituting treatment. The patient healed completely after 1 year and has been incident free since the past 10 years. In essence, this case has shown that multi-modality treatment may lead to faster wound closure and reduction in pain in SCD patients suffering from osteomyelitis.
C1 [Kakar, Jayesh] Geetha Multispecialty Hosp, Rd 4,West Marredpally, Hyderabad 500026, Telangana, India.
RP Kakar, J (通讯作者)，Geetha Multispecialty Hosp, Rd 4,West Marredpally, Hyderabad 500026, Telangana, India.
EM drjayeshkakar@gmail.com
CR Booth C, 2010, INT J INFECT DIS, V14, pE2, DOI 10.1016/j.ijid.2009.03.010
NR 1
TC 5
Z9 5
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 208
EP 209
AR 1534734620971068
DI 10.1177/1534734620971068
EA NOV 2020
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000599538600001
PM 33169631
DA 2026-07-24
ER

PT J
AU Schmuckler, J
AF Schmuckler, Jo
TI Acoustic pressure wound therapy to facilitate granulation tissue in
   sacral pressure ulcers in patients with compromised mobility: A case
   series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE acoustic pressure wound therapy; pressure ulcers; debridement; wound
   care
ID ULTRASOUND THERAPY
AB Electrical stimulation and other modalities are recommended for treatment of pressure ulcers in spinal cord injury patients but their use may be limited by clinical contraindications such as necrosis and infection. Acoustic pressure wound therapy can be used to address infection and has no known contraindications related to wound status. A retrospective nonconsecutive study was conducted involving five inpatients with sacral pressure ulcers and compromised mobility (spinal cord injury, ventilator/mobility dependency, or persistent vegetative state) treated with acoustic pressure wound therapy three times per week, 4 to 6 minutes per session, for 5 weeks to 5.5 months. Acoustic pressure wound therapy was administered until necrotic tissue was removed, granulation was complete, drainage resolved to moderate levels, and wound size was compatible with indications for high-voltage electrical stimulation. Within 1 to 4 weeks of starting acoustic pressure wound therapy, four out of five wounds with substantial yellow slough or eschar demonstrated 100% granulation tissue and wound area and volume decreased 71% to 97% and 75% to 99%, respectively. Subsequent treatments included electrical stimulation alone (three patients) or in conjunction with negative pressure wound therapy (one patient), and silver foam (one patient), Acoustic pressure wound therapy was found to be an effective option in preparing wounds for subsequent therapy.
C1 Kindred Hosp, Havertown, PA USA.
RP Schmuckler, J (通讯作者)，Kindred Hosp, Havertown, PA USA.
CR [Anonymous], 2001, J SPINAL CORD MED S1, V24, pS40
   BLACK J, 2007, UROL NURS, V27, P156
   Black Joyce, 2007, Urol Nurs, V27, P144
   BUTH L, 2008, S ADV WOUND CAR SAN
   *CELL INC, 2006, MIST THER SYST INSTR
   COLE P, 2007, S ADV WOUND CAR TAMP
   Ennis WJ, 2005, OSTOMY WOUND MANAG, V51, P24
   HAAN J, 2007, S ADV WOUND CAR TAMP
   Kavros Steven J, 2007, Adv Skin Wound Care, V20, P221, DOI 10.1097/01.ASW.0000266660.88900.38
   Kent Dea J, 2007, Nursing, V37, P36
   Redelings Matthew D, 2005, Adv Skin Wound Care, V18, P367, DOI 10.1097/00129334-200509000-00010
   THURMAN K, 2007, S ADV WOUND CAR TAMP
   TURKOS MA, 2007, S ADV WOUND CAR TAMP
   Unger PG, 2008, OSTOMY WOUND MANAG, V54, P57
   Whitney J, 2006, WOUND REPAIR REGEN, V14, P663, DOI 10.1111/j.1524-475X.2006.00175.x
NR 15
TC 9
Z9 9
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD AUG
PY 2008
VL 54
IS 8
BP 50
EP 53
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 341VD
UT WOS:000258742400006
PM 18716342
DA 2026-07-24
ER

PT J
AU Grabinska, A
   Michalczyk, L
   Banaczyk, B
   Syrylo, T
   Zabkowski, T
AF Grabinska, Agnieszka
   Michalczyk, Lukasz
   Banaczyk, Beata
   Syrylo, Tomasz
   Zabkowski, Tomasz
TI Management protocol for Fournier's gangrene in sanitary regime caused by
   SARS-CoV-2 pandemic: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Fournier&#8217; s gangrene; Management; Negative pressure wound therapy;
   Treatment; Orchiectomy; Case report; Necrotic tissues; SARS-CoV-2
AB BACKGROUND
   Fournier's gangrene (FG) is a serious, aggressive and often deadly polymicrobial infection of the soft tissues of the perineum, the rectum and the external genital organs. It is an anatomical subcategory of necrotizing fasciitis, which has a similar etiology and treatment strategy.
   CASE SUMMARY
   A 60-year-old man was admitted to the hospital during severe acute respiratory syndrome coronavirus 2 pandemic with complaints of fever up to 38.9 degrees C, abdominal pain, and edema of the scrotum, the penis, the perineum, and the right gluteal region for 2 d. Computed tomography of the abdomen and the pelvis revealed extensive inflammatory infiltrations of the subcutaneous tissue of the hypogastrium, and the penis; along with liquefaction and presence of gas in the subcutaneous tissues of the scrotum, the perineum, and the right gluteal region. The patient was diagnosed with FG, and was urgently qualified to undergo surgery in the Department of Urology. After performing the necessary examinations, a resection of the necrotic tissues with bilateral orchiectomy and excision of the penile and scrotal skin was performed. After surgery, he was transferred to the intensive care unit for further management.
   CONCLUSION
   Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.
C1 [Grabinska, Agnieszka; Syrylo, Tomasz; Zabkowski, Tomasz] Mil Inst Med, Dept Urol, 128 Szaserow, PL-04141 Warsaw, Poland.
   [Michalczyk, Lukasz; Banaczyk, Beata] Praski Hosp Warsaw, Dept Urol & Oncol Urol, PL-04141 Warsaw, Poland.
C3 Military Institute of Aviation Medicine
RP Zabkowski, T (通讯作者)，Mil Inst Med, Dept Urol, 128 Szaserow, PL-04141 Warsaw, Poland.
EM urodent@wp.pl
RI Zabkowski, Tomasz/H-8645-2018
CR Bhargav NarendraJ., 2020, WORLD J CURR MED PHA, V2, P191
   Chennamsetty A, 2015, THER ADV UROL, V7, P203, DOI 10.1177/1756287215584740
   Furr J, 2017, UROLOGY, V102, P79, DOI 10.1016/j.urology.2016.09.021
   Hota Prasan Kumar, 2012, Case Rep Emerg Med, V2012, P984195, DOI 10.1155/2012/984195
   Kim SY, 2015, UROLOGY, V85, P1052, DOI 10.1016/j.urology.2014.08.063
   Lauerman MH, 2017, J TRAUMA ACUTE CARE, V83, P443, DOI [10.1097/TA.0000000000001562, 10.1097/ta.0000000000001562]
   Li C, 2015, UROL INT, V94, P453, DOI 10.1159/000366137
   Puvanendran R, 2009, CAN FAM PHYSICIAN, V55, P981
   Roghmann F, 2012, BJU INT, V110, P1359, DOI 10.1111/j.1464-410X.2012.11082.x
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   Subrahmanyam M., 2004, Indian Journal of Surgery, V66, P75
   Taylor GM, 2018, OXF MED CASE REP, P48, DOI 10.1093/omcr/omx094
NR 12
TC 1
Z9 4
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 16
PY 2021
VL 9
IS 5
BP 1215
EP 1220
DI 10.12998/wjcc.v9.i5.1215
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QL9SL
UT WOS:000621420500025
PM 33644187
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Wijewardena, A
   Lajevardi, SS
   Vandervord, E
   Vandervord, J
   Lang, TC
   Fulcher, G
   Jackson, CJ
AF Wijewardena, Aruna
   Lajevardi, Sepehr S.
   Vandervord, Elle
   Vandervord, John
   Lang, Thomas C.
   Fulcher, Gregory
   Jackson, Christopher J.
TI Activated protein C to heal pressure ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Activated protein C; Chronic; Pressure ulcer; Topical negative pressure;
   Wound
ID PREVENTION
AB Pressure ulcers present a major clinical challenge, are physically debilitating and place the patient at risk of serious comorbidities such as septic shock. Recombinant human activated protein C (APC) is an anticoagulant with anti-inflammatory, cytoprotective and angiogenic effects that promote rapid wound healing. Topical negative pressure wound therapy (TNP) has become widely used as a treatment modality in wounds although its efficacy has not been proven through randomised controlled trials. The aim of this study was to determine the preliminary efficacy and safety of treatment with APC for severe chronic pressure sores with and without TNP. This case presentation describes the history, management and outcome of two patients each with a severe chronic non-healing pressure ulcer that had failed to respond to conventional therapy. TNP was added to conservative management of both ulcers with no improvement seen. Then local application of small doses of APC was added to TNP and with conservative management, resulted in significant clinical improvement and rapid healing of both ulcers, displaying rapid growth of vascular granulation tissue with subsequent epithelialisation. Patients tolerated the treatment well and improvements suggested by long-term follow-up were provided. Randomised placebo-controlled double blind trials are needed to quantify the efficacy, safety, cost-effectiveness, optimal dose and quality of life changes seen from treatment with APC.
C1 [Wijewardena, Aruna; Lajevardi, Sepehr S.; Vandervord, Elle; Vandervord, John] Royal North Shore Hosp, Dept Burns & Plast & Reconstruct Surg, St Leonards, NSW, Australia.
   [Lang, Thomas C.; Jackson, Christopher J.] Univ Sydney, Kolling Inst Med Res, Sutton Res Labs, St Leonards, NSW, Australia.
   [Fulcher, Gregory] Univ Sydney, Royal North Shore Hosp, Dept Endocrinol, St Leonards, NSW, Australia.
C3 Royal North Shore Hospital; University of Sydney; Kolling Institute of
   Medical Research; Royal North Shore Hospital; University of Sydney
RP Jackson, CJ (通讯作者)，Univ Sydney, Kolling Inst Med Res, Sutton Res Labs, St Leonards, NSW, Australia.
EM chris.jackson@sydney.edu.au
OI Lang, Thomas/0000-0003-3961-5558; Jackson,
   Christopher/0000-0002-9234-9116
CR [Anonymous], COCHRANE DATABASE SY
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   Whitmont K, 2015, INT WOUND J, V12, P422, DOI 10.1111/iwj.12125
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   Wijewardena A, 2011, INT J LOW EXTR WOUND, V10, P146, DOI 10.1177/1534734611417342
NR 25
TC 13
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 986
EP 991
DI 10.1111/iwj.12343
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600113
PM 25185858
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Aktas, S
   Baktiroglu, S
   Demir, L
   Kilicoglu, Ö
   Topalan, M
   Güven, E
   Mirasoglu, B
   Yanar, F
AF Aktas, Samil
   Baktiroglu, Selcuk
   Demir, Levent
   Kilicoglu, Onder
   Topalan, Murat
   Guven, Erdem
   Mirasoglu, Bengusu
   Yanar, Fatih
TI Intralesional application of epidermal growth factor in limb-threatening
   ischemic diabetic foot ulcers
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA English
DT Article
DE Diabetic foot ulcer; epidermal growth factor; leg amputation
ID PERIPHERAL ARTERIAL-DISEASE; RANDOMIZED-CONTROLLED-TRIAL;
   HYPERBARIC-OXYGEN THERAPY; PRESSURE WOUND THERAPY; MULTICENTER;
   AMPUTATION; RISK; EPIDEMIOLOGY; METAANALYSIS; PREVALENCE
AB Objective: The intralesional injection of recombinant human epidermal growth factor (EGF-IL), a new therapy, has been claimed to prevent major amputations in advanced diabetic foot lesions. In this study, the efficacy of EGF-IL on advanced diabetic foot ulcers (DFU) was reviewed.
   Methods: Intralesional 75 mu g EGF application (Heberprot-P (R) 75, Heber Biotec, Havana, Cuba) to 12 diabetic foot lesions in 11 patients (8 males, 3 females; mean age: 62.2 +/- 10.6 years) was evaluated. Most of the patients had undergone revascularization and received hyperbaric oxygen therapy (HBOT) and negative pressure wound therapy (NPWT), along with standard care, but failed to heal. After amputation was offered as the final option, EGF-IL was applied to evaluate its effects.
   Results: Two patients underwent amputation, while 10 lesions of the remaining 9 patients healed completely.
   Conclusion: Our results prove that intralesional application of EGF can prevent amputations in advanced diabetic foot cases with an ischemic component. However, evidence in the literature supporting its use remains lacking, and its high cost presents an additional problem. Thus, we believe that intralesional application of EGF should be an option for ischemic wounds only after vascular evaluation (and intervention when possible), HBOT, NPWT, and standard care have proven insufficient.
C1 [Aktas, Samil; Mirasoglu, Bengusu] Istanbul Univ, Istanbul Fac Med, Dept Underwater & Hyperbar Med, Istanbul, Turkey.
   [Baktiroglu, Selcuk; Yanar, Fatih] Istanbul Univ, Istanbul Fac Med, Dept Gen Surg, Istanbul, Turkey.
   [Demir, Levent] Van Reg Hosp, Dept Underwater & Hyperbar Med, Van, Turkey.
   [Kilicoglu, Onder] Istanbul Univ, Istanbul Fac Med, Dept Ortopaed & Traumatol, Istanbul, Turkey.
   [Topalan, Murat; Guven, Erdem] Istanbul Univ, Istanbul Fac Med, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
C3 Istanbul University; Istanbul University; Istanbul University; Istanbul
   University
RP Aktas, S (通讯作者)，Istanbul Univ, Istanbul Tip Fak, Sualti Hekimligi & Hiperbar Tip Anabilim Dali, Istanbul, Turkey.
EM samilaktas@yahoo.com
RI Yanar, Fatih/ABD-7839-2020; Kılıçoğlu, Önder İsmet/B-2810-2011;
   /AAE-7277-2020; /AAD-6656-2020; DEMİR, Levent/KXR-6680-2024
OI Yanar, Fatih/0000-0002-9091-3246; Kılıçoğlu, Önder
   İsmet/0000-0003-0023-7094; 
CR Abidia A, 2003, EUR J VASC ENDOVASC, V25, P513, DOI 10.1053/ejvs.2002.1911
   Acosta Jorge Berlanga, 2006, Int Wound J, V3, P232, DOI 10.1111/j.1742-481X.2006.00237.x
   Al-Delaimy WK, 2004, AM J MED, V116, P236, DOI 10.1016/j.amjmed.2003.09.038
   Albers M, 2006, J VASC SURG, V43, P498, DOI 10.1016/j.jvs.2005.11.025
   Rubio JA, 2014, INT J LOW EXTR WOUND, V13, P22, DOI 10.1177/1534734614521234
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Bhatt DL, 2006, JAMA-J AM MED ASSOC, V295, P180, DOI 10.1001/jama.295.2.180
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   COHEN S, 1962, J BIOL CHEM, V237, P1555
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   Frykberg R G, 2000, J Foot Ankle Surg, V39, pS1
   Gesell LB, HYPERBARIC OXYGEN TH, P4
   Hinchliffe RJ, 2012, DIABETES-METAB RES, V28, P179, DOI 10.1002/dmrr.2249
   Inan B, 2013, ARCH MED SCI, V9, P1078, DOI 10.5114/aoms.2013.39630
   Löndahl M, 2010, DIABETES CARE, V33, P998, DOI 10.2337/dc09-1754
   Margolis DJ, 2013, MED CLIN N AM, V97, P791, DOI 10.1016/j.mcna.2013.03.008
   Moulik PK, 2003, DIABETES CARE, V26, P491, DOI 10.2337/diacare.26.2.491
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   Romiti M, 2008, J VASC SURG, V47, P975, DOI 10.1016/j.jvs.2008.01.005
   Satman I, 2002, DIABETES CARE, V25, P1551, DOI 10.2337/diacare.25.9.1551
   Satman I, 2013, EUR J EPIDEMIOL, V28, P169, DOI 10.1007/s10654-013-9771-5
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   Velázquez Wilver, 2010, Biotecnol Apl, V27, P136
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
NR 27
TC 13
Z9 19
U1 0
U2 17
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   TURKEY
SN 1017-995X
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD MAY-JUN
PY 2016
VL 50
IS 3
BP 277
EP 283
DI 10.3944/AOTT.2015.14.0434
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DN7AO
UT WOS:000377227900005
PM 27130382
OA Green Published, Green Submitted
DA 2026-07-24
ER

PT J
AU Hayn, E
AF Hayn, Ernesto
TI Successful treatment of complex traumatic and surgical wounds with a
   foetal bovine dermal matrix
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dermal repair; Plastic surgery; Reconstructive surgery; Trauma; Wound
   healing
ID BIOENGINEERED SKIN; COVERAGE
AB A foetal bovine dermal repair scaffold (PriMatrix, TEI Biosciences) was used to treat complex surgical or traumatic wounds where the clinical need was to avoid skin flaps and to build new tissue in the wound that could be reepithelialised from the wound margins or closed with a subsequent application of a split-thickness skin graft (STSG). Forty-three consecutive cases were reviewed having an average size of 793 cm(2), 50% of which had exposed tendon and/or bone. In a subset of wounds (447%), the implantation of the foetal dermal collagen scaffold was also augmented with negative pressure wound therapy (NPWT). Complete wound healing was documented in over 80% of the wounds treated, whether the wound was treated with the foetal bovine dermal scaffold alone (952%) or when supplemented with NPWT (824%). The scaffold successfully incorporated into wounds with exposed tendon and/or bone to build vascularised, dermal-like tissue. The new tissue in the wound supported STSGs however, in the majority of the cases (883%); wound closure was achieved through reepithelialisation of the incorporated dermal scaffold by endogenous wound keratinocytes. The foetal bovine dermal repair scaffold was found to offer an effective alternative treatment strategy for definitive closure of challenging traumatic or surgical wounds on patients who were not suitable candidates for tissue flaps.
C1 Plast Surg Palm Beach, Wellington, FL 33414 USA.
RP Hayn, E (通讯作者)，Plast Surg Palm Beach, 10115 W Forest Hill Blvd,400, Wellington, FL 33414 USA.
EM Docehayn@gmail.com
CR Cornwell Kevin G, 2009, Clin Podiatr Med Surg, V26, P507, DOI 10.1016/j.cpm.2009.08.001
   Dunckel AP, 2009, OSTOMY WOUND MANAG, V55, P44
   Higgs W.R., 2010, Wound Care Hyperb. Med, V1, P9
   Higgs W.R., 2010, Wound Care Hyperb. Med, V1, P8
   Janis JE, 2011, PLAST RECONSTR SURG, V127, p205S, DOI 10.1097/PRS.0b013e318201271c
   Jensen M, 2008, ORTHOP CLIN N AM, V39, P251, DOI 10.1016/j.ocl.2007.12.009
   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   Komorowska-Timek E, 2005, PLAST RECONSTR SURG, V115, P1010, DOI 10.1097/01.PRS.0000154210.60284.C6
   Kosutic D, 2013, MICROSURG, V33, P77, DOI 10.1002/micr.22034
   Landsman Adam, 2009, Clin Podiatr Med Surg, V26, P525, DOI 10.1016/j.cpm.2009.08.012
   Lazic T, 2011, PLAST RECONSTR SURG, V127, p75S, DOI 10.1097/PRS.0b013e3182009d9f
   Leon-Villapalos J, 2010, CELL TISSUE BANK, V11, P99, DOI 10.1007/s10561-009-9152-1
   Limova M, 2010, SURG CLIN N AM, V90, P1237, DOI 10.1016/j.suc.2010.08.004
   Lineen E, 2008, J CRANIOFAC SURG, V19, P923, DOI 10.1097/SCS.0b013e318175b5ab
   Lullove E, 2012, J AM PODIAT MED ASSN, V102, P233, DOI 10.7547/1020233
   Muangman P, 2006, ANN PLAS SURG, V57, P199, DOI 10.1097/01.sap.0000218636.61803.d6
   Neill J, 2012, ANN PLAS SURG, V68, P451, DOI 10.1097/SAP.0b013e31824189ed
   Simman Richard, 2009, J Am Col Certif Wound Spec, V1, P6, DOI 10.1016/j.jcws.2008.10.003
   Wanitphakdeedecha R., 2008, J Drugs Dermatol, V7, P2
NR 19
TC 26
Z9 29
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2014
VL 11
IS 6
BP 675
EP 680
DI 10.1111/iwj.12028
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AU3JS
UT WOS:000345509700018
PM 23452161
OA Green Submitted
DA 2026-07-24
ER

PT J
AU da Rocha, CC
   Filizzola, RL
   Sorrenti, L
   Cho, AB
   Ferreira, CHV
   Kiyohara, LY
   de Souza, ERA
   da Silva, CR
AF da Rocha, Cleyton Chaves
   Filizzola, Ricardo Lavorato
   Sorrenti, Luiz
   Cho, Alvaro Baik
   Ferreira, Carlos Henrique Vieira
   Kiyohara, Leandro Yoshinobu
   de Souza, Eduardo Romera Alves
   da Silva, Carina Rocha
TI NEGATIVE PRESSURE WOUND THERAPY AS AN ADJUNCT TO SKIN GRAFTING IN
   TRAUMATIC INJURIES TERAPIA POR PRESSÃO NEGATIVA COMO ADJUVANTE AOS
   ENXERTOS DE PELE EM LESÕES TRAUMÁTIC AS
SO ACTA ORTOPEDICA BRASILEIRA
LA English
DT Article
DE Skin Transplantation; Patient Isolators; Low Cost Tech-nology; Wounds
   and Injuries
AB Introduction: Wounds are a challenge for health professionals and services, prolonging hospital stays and increasing morbidity and mortality rates. Wounds occur due to post-traumatic tissue loss, which is often difficult to resolve and is complicated by infections, local vascular impairment, and systemic diseases. To demonstrate the effectiveness of negative pressure therapy (NPT) using the vacuum gauge of the hospital gas pipeline and low-cost materials in the immediate postoperative period. To use resources available in daily hospital practice to create a low-cost vacuum dressing. To describe the equipment, preparation, and technique involved in low-cost NPT treatment as an adjuvant in the repair of lesions with indication for skin grafting. Methodology: Prospective, interventional, randomized clinical study with a non-inferiority design. Results: Fifteen patients were included at the end of the study, with complete follow-up until complete healing. The mean age of the selected patients was 38.27 years. Regarding gender, 93.3% were male and 6.7% were female. Conclusion: Thus, the results suggested that the use of low-cost NPT on skin grafts is a valuable, safe, easily reproducible and low-morbidity tool for surgeons technical arsenal. Level of Evidence: IV; Case Series.
C1 [da Rocha, Cleyton Chaves; Filizzola, Ricardo Lavorato; Sorrenti, Luiz; Cho, Alvaro Baik; Ferreira, Carlos Henrique Vieira; Kiyohara, Leandro Yoshinobu; de Souza, Eduardo Romera Alves; da Silva, Carina Rocha] Hosp Estadual Mario Covas, Fac Med ABC, Grp Cirurgia Mao & Microcirurgia, Sao Paulo, SP, Brazil.
C3 Faculdade de Medicina do ABC
RP da Rocha, CC (通讯作者)，Cond Mini Chacaras Lago Sul, Quadra 06 Conjunto 03,Casa 32, BR-71680621 Brasilia, DF, Brazil.
EM cleyton.rocha@yahoo.com.br
RI /AAR-8652-2021
OI Romera Alves de Souza, Eduardo/0000-0001-8414-2150
CR Alves L. M., 2009, Revista de Ciencias Medicas, V18, P201
   Brasil. Ministerio da Saude, 2023, B EPIDEMIOLOGICO ACI
   Condé-Green A, 2013, ANN PLAS SURG, V71, P394, DOI 10.1097/SAP.0b013e31824c9073
   Dos Santos TL, 2019, Revista Eletrônica Acervo Saúde, pe1231, DOI [10.25248/reas.e1231.2019, 10.25248/reas.e1231.2019, DOI 10.25248/REAS.E1231.2019]
   2024, Journal of Wound Management Official journal of the European Wound Management Association, DOI [10.35279/jowm2024.25.02.sup01, 10.35279/jowm2024.25.02.sup01, DOI 10.35279/JOWM2024.25.02.SUP01]
   Gao JR, 2021, J ADV NURS, V77, P3980, DOI 10.1111/jan.14876
   Kamamoto Fabio, 2016, ESTUDO COMPARATIVO E
   LIMA RENAN VICTOR KÜMPEL SCHMIDT, 2017, Rev. Col. Bras. Cir., V44, P81, DOI [10.1590/0100-69912017001001, 10.1590/0100-69912017001001]
   Matthew EB, 2023, SPLIT THICKNESS SKIN
   Scalise A, 2016, INT WOUND J, V13, P1260, DOI 10.1111/iwj.12492
   SOUZA SANDRO CILINDRO DE, 2023, Rev. Bras. Cir. Plást., V38, pe0731, DOI [10.5935/2177-1235.2023rbcp0731-pt, 10.5935/2177-1235.2023rbcp0731-pt]
   Souza SC, 2021, CURATIVO VACUO SIMPL
   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
NR 13
TC 0
Z9 0
U1 0
U2 0
PU ATHA COMUNICACAO & EDITORA
PI SAO PAULO
PA RUA MACHADO BITTENCOURT, 190-40 ANDAR, CONJ 410, SAO PAULO, Sao Paulo,
   BRAZIL
SN 1413-7852
EI 1809-4406
J9 ACTA ORTOP BRAS
JI Acta Ortop. Bras.
PY 2026
VL 34
IS 1
AR e292923
DI 10.1590/1413-785220263401e292923
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HY5VP
UT WOS:001765760100004
PM 41924016
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Visser, R
   Milbrandt, K
   LumMin, S
   Wiseman, N
   Hancock, BJ
   Morris, M
   Keijzer, R
AF Visser, Robin
   Milbrandt, Kris
   LumMin, Suyin
   Wiseman, Nathan
   Hancock, Betty-Jean
   Morris, Melanie
   Keijzer, Richard
TI Applying vacuum to accomplish reduced wound infections in laparoscopic
   pediatric surgery
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the Canadian-Association-of-Pediatric-Surgeons
   (CAPS)
CY SEP 22-24, 2016
CL Vancouver, CANADA
SP Canadian Assoc Pediat Surg
DE Vacuum dressing; Pediatric laparoscopic surgery; Surgical site infection
ID SURGICAL SITE INFECTIONS; ASSISTED CLOSURE; RISK-FACTORS; INCISION
   MANAGEMENT; APPENDECTOMY; CHILDREN; POPULATION; EXPERIENCE; OUTCOMES;
   THERAPY
AB Introduction: The prevention of surgical site infections has received little attention in pediatric surgery. Negative pressure wound therapy is used to treat complex wounds. We hypothesized that this principle could reduce wound infection rates following laparoscopic surgery. We tested this in a randomized controlled trial.
   Materials and methods: We randomized pediatric patients with an umbilical port site to a standard dressing or a vacuum dressing. The dressings were removed 48 h after surgery. A nurse blinded for the treatment inspected the umbilical wound between post-operative days 7-10 for infection. Data comparison was performed using a Fisher exact test with p < 0.05 defined as significant.
   Results: We recruited 90 patients over 2 years and randomized 44 to the vacuum dressing arm and 42 to the control arm. We observed a 2.8% (n = 1/35) infection rate in the vacuum dressing group and 3.3% (n = 1/30) in the control group (p = 1.0).
   Discussion: We ended our study early when an interim analysis showed an impractical number of patients would be required to achieve sufficient power. We did not find a significant difference between the control and vacuum dressings in reducing post-operative wound infections. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Visser, Robin] Univ Manitoba, Dept Gen Surg, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Div Pediat Surg, Dept Surg, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada.
   [Milbrandt, Kris; LumMin, Suyin; Wiseman, Nathan; Hancock, Betty-Jean; Morris, Melanie; Keijzer, Richard] Univ Manitoba, Childrens Hosp, Res Inst Manitoba, Winnipeg, MB, Canada.
C3 University of Manitoba; University of Manitoba; University of Manitoba;
   University of Manitoba; Children's Hospital Research Institute of
   Manitoba (CHRIM)
RP Keijzer, R (通讯作者)，Univ Manitoba, AE402-840 Sherbrook St, Winnipeg, MB R3A 1R9, Canada.
EM richardkeijzer@gmail.com
RI Keijzer, Richard/AAA-9598-2020
OI Keijzer, Richard/0000-0002-0108-3157
FU Children's Hospital Research Institute of Manitoba
FX We would like to thank all the personnel who helped make this trial a
   reality, including but not limited to the residents; operating theater,
   ward, and research nurses; attending surgeons; and our secretary Brandi.
   Thank you to the Children's Hospital Research Institute of Manitoba who
   provided grant funding.
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NR 42
TC 11
Z9 12
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAY
PY 2017
VL 52
IS 5
BP 849
EP 852
DI 10.1016/j.jpedsurg.2017.01.035
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA EU5UC
UT WOS:000401098300037
PM 28245914
DA 2026-07-24
ER

PT J
AU Liu, H
   Li, YX
   Sun, QB
   Yang, JQ
   Zhao, Y
   Cui, XY
   Tian, Y
AF Liu, He
   Li, Yanxuan
   Sun, Qianbu
   Yang, Jiaqi
   Zhao, Yue
   Cui, Xiaoyu
   Tian, Ye
TI Triboelectric wearable devices for accelerated wound healing
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Review
DE Triboelectric nanogenerators; Wound healing; Electrical stimulation;
   Antibacterial; Cell proliferation; Drug delivery
ID NANOGENERATORS; SENSOR; STIMULATION; ELECTRODE
AB Electrical stimulation (ES), as a non-pharmacological physical stimulation, has been widely used in clinical treatment due to its ability to promote cell proliferation and tissue repair. Wearable devices based on triboelectric nanogenerator (TENG), which is a novel self-powered system, can generate high power density and biocompatible ES, showing great healing effects in ex vivo and in vivo wound therapy. Here, a review of emerging triboelectric wearable devices for accelerated wound healing is presented. First, types, properties and selection principles of the prepared materials are specifically discussed. Then, structure and mechanism of triboelectric wearable healing devices are discussed focusing on the vertical contact-separation structure, singleelectrode structure, lateral sliding structure and freestanding triboelectric-layer structure, while comparing the advantages of different structures, suitable ES actuation modes, and targeted wound types. Notably, combination treatment methods were summarized, including negative pressure wound therapy, photothermal therapy, drug delivery system and wound monitoring system. Next, therapeutic effects of triboelectric wearable healing device is described in detail, including elimination of wound bacterial infection, promotion of cell proliferation and migration, and enhancement of transdermal drug delivery. Finally, the current challenges and future prospects of triboelectric wearable healing devices are discussed in depth. This review provides guidance for the design of triboelectric wearable healing devices, which will facilitate the further development of personalized wearable accelerated wound therapy.
C1 [Liu, He; Li, Yanxuan; Sun, Qianbu; Yang, Jiaqi; Zhao, Yue; Cui, Xiaoyu; Tian, Ye] Northeastern Univ, Coll Med & Biol Informat Engn, Shenyang 110169, Peoples R China.
   [Tian, Ye] Northeastern Univ, Foshan Grad Sch Innovat, Foshan 528300, Peoples R China.
C3 Northeastern University - China; Northeastern University - China
RP Tian, Y (通讯作者)，Northeastern Univ, Coll Med & Biol Informat Engn, Shenyang 110169, Peoples R China.
EM tianye@bmie.neu.edu.cn
RI Cui, Xiaoyu/N-9336-2017; Yang, Jiaqi/ABD-3720-2021; Tian,
   Ye/JTS-3682-2023
FU National Natural Science Foundation of China [32201179]; National Key R
   & D Program of China [2023YFC2508200]; Liaoning Provincial Natural
   Science Foundation Joint Fund (General Support Program Project)
   [2023-MSBA-093]; Fundamental Research Funds for the Central Universities
   [N2319005, N2424010-19]
FX The financial support from the National Natural Science Foundation of
   China (32201179) , National Key R & D Program of China (2023YFC2508200)
   , Liaoning Provincial Natural Science Foundation Joint Fund (General
   Support Program Project) (2023-MSBA-093) and the Fundamental Research
   Funds for the Central Universities (N2319005 and N2424010-19) is
   gratefully acknowledged.
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NR 115
TC 34
Z9 37
U1 18
U2 168
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD OCT 1
PY 2024
VL 497
AR 154628
DI 10.1016/j.cej.2024.154628
EA AUG 2024
PG 17
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA D2C8Z
UT WOS:001294325800001
DA 2026-07-24
ER

PT J
AU Asukai, K
   Kashiwazaki, M
   Koizumi, K
   Nobunaga, T
   Yano, H
AF Asukai, Kei
   Kashiwazaki, Masaki
   Koizumi, Kaori
   Nobunaga, Toshikatsu
   Yano, Hiroshi
TI A case report of a 19-week gravid patient with a dehisced abdominal
   wound and treated with VAC ATS® Therapy System
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dehisced wound; Dehiscence; Gravid; Pregnant; VAC Therapy
ID FIBRIN MATRIX; PROLIFERATION
AB Negative pressure wound therapy (NPWT) is an effective treatment for various non-healing wounds, and V.A.C.(R) Therapy was the first-approved NPWT device by the Japanese government in 2009. We report the case of a 19-week pregnant patient where V.A.C.(R) Therapy was applied to her dehisced laparotomy wound with satisfactory results. The patient was a 30-year-old female who was referred to our hospital from her previous doctor because of the presence of an ovarian cyst on the left ovary. The patient presented at 14weeks into her pregnancy, and surgery was considered because of no reduction in the size of the cyst. An oophorocystectomy was performed, and then the surgical incision was re-opened at postoperative day (POD) 10 due to a surgical site infection. V.A.C.(R) Therapy was initiated on POD 26 (20weeks of pregnancy) and continued for 28 days. After 28 days of V.A.C.(R) Therapy (POD 54), the wound was sutured for complete closure. The foetus did not experience any adverse affects from the surgery and, subsequently, normal vaginal delivery was achieved. This case is the first report of the use of V.A.C.(R) Therapy over a dehisced abdominal wound on a pregnant patient in our country.
C1 [Asukai, Kei; Kashiwazaki, Masaki; Yano, Hiroshi] Hyogo Prefectural Nishinomiya Hosp, Dept Gen Surg, 13-9 Rokutanji Cho, Nishinomiya, Hyogo 6620918, Japan.
   [Koizumi, Kaori; Nobunaga, Toshikatsu] Hyogo Prefectural Nishinomiya Hosp, Dept Obstet & Gynecol, Nishinomiya, Hyogo, Japan.
RP Kashiwazaki, M (通讯作者)，Hyogo Prefectural Nishinomiya Hosp, Dept Gen Surg, 13-9 Rokutanji Cho, Nishinomiya, Hyogo 6620918, Japan.
EM kashiwazaki0707@hp.pref.hyogo.jp
CR Akaishi S, 2007, JPN J SCAR KELOID TR, V1, P63
   Chida H, 2012, JPN MED J IWATE PREF, V52, P32
   Gupta S, 2012, INT WOUND J, V9, pIII, DOI 10.1111/j.1742-481X.2012.00978.x
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NR 12
TC 4
Z9 4
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 992
EP 995
DI 10.1111/iwj.12352
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600114
PM 25209461
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Akers, KS
   Rowan, MP
   Niece, KL
   Graybill, JC
   Mende, K
   Chung, KK
   Murray, CK
AF Akers, Kevin S.
   Rowan, Matthew P.
   Niece, Krista L.
   Graybill, John C.
   Mende, Katrin
   Chung, Kevin K.
   Murray, Clinton K.
TI Antifungal wound penetration of amphotericin and voriconazole in
   combat-related injuries: case report
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Invasive fungal infection; Pharmacokinetics; Negative-Pressure Wound
   Therapy; NPWT; Effluent
ID INVASIVE FUNGAL-INFECTIONS; B DEOXYCHOLATE; EXPRESSION; PLASMA;
   PHARMACOKINETICS; EPIDEMIOLOGY; BATTLEFIELD; BIOMARKERS; CYTOKINE;
   REGIMENS
AB Background: Survivors of combat trauma can have long and challenging recoveries, which may be complicated by infection. Invasive fungal infections are a rare but serious complication with limited treatment options. Currently, aggressive surgical debridement is the standard of care, with antifungal agents used adjunctively with uncertain efficacy. Anecdotal evidence suggests that antifungal agents may be ineffective in the absence of surgical debridement, and studies have yet to correlate antifungal concentrations in plasma and wounds.
   Case presentation: Here we report the systemic pharmacokinetics and wound effluent antifungal concentrations of five wounds from two male patients, aged 28 and 30 years old who sustained combat-related blast injuries in southern Afghanistan, with proven or possible invasive fungal infection. Our data demonstrate that while voriconazole sufficiently penetrated the wound resulting in detectable effluent levels, free amphotericin B (unbound to plasma) was not present in wound effluent despite sufficient concentrations in circulating plasma. In addition, considerable between-patient and within-patient variability was observed in antifungal pharmacokinetic parameters.
   Conclusion: These data highlight the need for further studies evaluating wound penetration of commonly used antifungals and the role for therapeutic drug monitoring in providing optimal care for critically ill and injured war fighters.
C1 [Akers, Kevin S.; Rowan, Matthew P.; Niece, Krista L.; Graybill, John C.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Akers, Kevin S.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
   [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
   [Chung, Kevin K.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
C3 Brooke Army Medical Center; Uniformed Services University of the Health
   Sciences - USA; Uniformed Services University of the Health Sciences -
   USA
RP Akers, KS (通讯作者)，US Army, Inst Surg Res, 3698 Chambers Pass,JBSA, Ft Sam Houston, TX 78234 USA.
EM kevin.s.akers.mil@mail.mil
OI Graybill, John Christopher/0000-0001-5823-2566
FU Defense Medical Research & Development Program (DMRDP) Military
   Infectious Disease Clinical Trial Award (MID-CTA)
   [D_MIDCTA_I_12_J2_299]; U.S. Department of Energy; USAMRMC
FX This study was conducted under a protocol reviewed and approved by the
   U.S. Army Medical Research and Materiel Command Institutional Review
   Board and in accordance with approved protocols BAMC C.2013.095 and
   H-09-059. This work was supported by Defense Medical Research &
   Development Program (DMRDP) Military Infectious Disease Clinical Trial
   Award (MID-CTA) #D_MIDCTA_I_12_J2_299, and in part by an appointment to
   the Postgraduate Research Participation Program at the U.S. Army
   Institute of Surgical Research administered by the Oak Ridge Institute
   for Science and Education through an interagency agreement between the
   U.S. Department of Energy and USAMRMC. A portion of this material was
   presented at the 2014 Military Health Systems Research Symposium, Ft.
   Lauderdale FL. We gratefully acknowledge the invaluable contributions of
   Doug Johnson LVN, Kristie Harnisch RN, Crystal Rosemann RN, Charnae
   Williams BS, and the participating research subjects, without whom this
   research would not be possible.
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NR 32
TC 31
Z9 33
U1 1
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD APR 15
PY 2015
VL 15
AR 184
DI 10.1186/s12879-015-0918-8
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA CG3PN
UT WOS:000353192200001
PM 25886578
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Singh, D
   Alton, T
   Alvand, A
   de Toledo, PRB
   Chatterjee, A
   Dillavou, E
   Djohan, R
   Ortega, AVG
   Pieri, A
   Sumpio, B
   Willy, C
   Zelle, B
   Cooper, HJ
AF Singh, Devinder
   Alton, Timothy
   Alvand, Abtin
   Barbosa de Toledo, Paulo Roberto
   Chatterjee, Abhishek
   Dillavou, Ellen
   Djohan, Risal
   Ortega, Alba Viviana Gomez
   Pieri, Andrew
   Sumpio, Bauer
   Willy, Christian
   Zelle, Boris
   Cooper, H. John
TI Linear and Area Coverage With Closed Incision Negative Pressure Therapy
   Management: International Multidisciplinary Consensus Recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE expert opinion; negative pressure wound therapy; risk factors; surgical
   wound; wound healing
ID SURGICAL-SITE INFECTION; WOUND THERAPY; KNEE ARTHROPLASTY; HIP;
   COMPLICATIONS; SURGERY; DRESSINGS; PREVENTION; WOMEN
AB Closed incision negative pressure therapy (ciNPT) with foam dressings has received broad recognition for its ability to support incision healing for a variety of surgical procedures. Over time, these dressings have evolved to include linear and 'area' shapes to better conform to different incision types and surface geometries. To address new studies on these configurations and provide guidance for dressing selection, an international, multidisciplinary panel of experts was convened. The panel reviewed recent publications on ciNPT with reticulated open cell foam (ROCF) dressings, shared their cases and experiences and engaged in roundtable discussions on benefits, drawbacks and technical challenges. Topics were ranked by importance and refined into potential consensus statements. These were shared for anonymous feedback, requiring 80% agreement for consensus. This manuscript establishes 12 consensus statements regarding risk factors supporting the use of ciNPT, conditions supporting preference of linear or area ciNPT dressings and tips for practical application of ciNPT with ROCF dressings. While this consensus panel expands on previous publications to aid clinicians' decision-making, further research is needed to refine recommendations and identify the strengths and limitations of ciNPT. Continued multidisciplinary collaboration will ensure ciNPT remains vital for improving surgical outcomes and patient care.
C1 [Singh, Devinder] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL USA.
   [Alton, Timothy] Proliance Orthopaed Associates, Renton, WA USA.
   [Alvand, Abtin] Oxford Univ Hosp NHS Trust, Nuffield Orthopaed Ctr, Oxford, England.
   [Barbosa de Toledo, Paulo Roberto] Hosp Quinta Dor, Dept Orthoped Trauma, Rio De Janeiro, Brazil.
   [Chatterjee, Abhishek] Tufts Med Ctr, Dept Surg, Boston, MA USA.
   [Dillavou, Ellen] WakeMed Hosp Syst, Dept Vasc Surg, Raleigh, NC USA.
   [Djohan, Risal] Cleveland Clin, Dermatol & Plast Surg Inst, Dept Plast Surg, Cleveland, OH USA.
   [Ortega, Alba Viviana Gomez] Fdn Santa Fe Bogota, Bogota, Colombia.
   [Pieri, Andrew] Royal Victoria Infirm, Newcastle Upon Tyne, England.
   [Sumpio, Bauer] Yale Univ, Sch Med, Dept Surg, New Haven, CT USA.
   [Willy, Christian] Mil Acad Hosp Berlin, Dept Surg, Berlin, Germany.
   [Zelle, Boris] Univ Texas Hlth San Antonio, Dept Orthopaed, San Antonio, TX USA.
   [Cooper, H. John] Colombia Univ, Dept Orthoped Surg, New York, NY USA.
C3 University of Miami; Nuffield Orthopaedic Centre; Oxford University
   Hospitals NHS Foundation Trust; Tufts Medical Center; Cleveland Clinic
   Foundation; Newcastle University - UK; Yale University; University of
   Texas System; University of Texas at San Antonio
RP Singh, D (通讯作者)，Univ Miami, Miller Sch Med, Dept Surg, Miami, FL USA.
EM dsingh.md@gmail.com
RI Cooper, H./H-3488-2019
FU Solventum Corporation (Maplewood, MN)
FX Funding for the advisory panel meeting was provided by Solventum
   Corporation (Maplewood, MN).
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NR 63
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2025
VL 22
IS 6
AR e70677
DI 10.1111/iwj.70677
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0227
UT WOS:001623124400001
PM 40432310
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Toume, S
   Gefen, A
   Weihs, D
AF Toume, Samer
   Gefen, Amit
   Weihs, Daphne
TI Low-level stretching accelerates cell migration into a gap
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cell migration; Gap closure; Mechanobiology; Sustained deformations;
   Wound healing
ID UNIAXIAL CYCLIC STRETCH; ENDOTHELIAL-CELLS; NEGATIVE-PRESSURE;
   MECHANOTRANSDUCTION; MORPHOGENESIS; THERAPY; FORCES
AB We observed that radially stretching cell monolayers at a low level (3%) increases the rate at which they migrate to close a gap formed by in vitro injury. Wound healing has been shown to accelerate in vivo when deformations are topically applied, for example, by negative pressure wound therapy. However, the direct effect of deformations on cell migration during gap closure is still unknown. Thus, we have evaluated the effect of radially applied, sustained (static) tensile strain on the kinematics of en mass cell migration. Monolayers of murine fibroblasts were cultured on stretchable, linear-elastic substrates that were subjected to different tensile strains, using a custom-designed three-dimensionally printed stretching apparatus. Immediately following stretching, the monolayer was wounded' at its centre, and cell migration during gap closure was monitored and quantitatively evaluated. We observed a significant increase in normalised migration rates and a reduction of gap closure time with 3% stretching, relative to unstretched controls or 6% stretch. Interestingly, the initial gap area was linearly correlated with the maximum migration rate, especially when stretching was applied. Therefore, small deformations applied to cell monolayers during gap closure enhance en mass cell migration associated with wound healing and can be used to fine-tune treatment protocols.
C1 [Toume, Samer; Weihs, Daphne] Technion Israel Inst Technol, Fac Biomed Engn, IL-3200003 Haifa, Israel.
   [Gefen, Amit] Tel Aviv Univ, Dept Biomed Engn, Fac Engn, Tel Aviv, Israel.
C3 Technion Israel Institute of Technology; Tel Aviv University
RP Weihs, D (通讯作者)，Technion Israel Inst Technol, Fac Biomed Engn, IL-3200003 Haifa, Israel.
EM daphnew@technion.ac.il
RI Weihs, Daphne/C-2860-2009; Gefen, Amit/M-4720-2015
OI Weihs, Daphne/0000-0002-9670-3418; Gefen, Amit/0000-0002-0223-7218
FU Israeli Ministry of Science and Technology Third Age Program
FX The work was partially supported by the Israeli Ministry of Science and
   Technology Third Age Program (DW and AG).
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NR 41
TC 19
Z9 21
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2017
VL 14
IS 4
BP 698
EP 703
DI 10.1111/iwj.12679
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FA2WQ
UT WOS:000405302600017
PM 27748039
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Yohannes, A
   Knievel, J
   Lange, J
   Dormann, AJ
   Hügle, U
   Eisenberger, CF
   Heiss, MM
AF Yohannes, Alexander
   Knievel, Judith
   Lange, Jonas
   Dormann, Arno J.
   Huegle, Ulrich
   Eisenberger, Claus F.
   Heiss, Markus M.
TI VacStent as an Innovative Approach in the Treatment of Anastomotic
   Insufficiencies and Leakages in the Gastrointestinal Tract-Review and
   Outlook
SO LIFE-BASEL
LA English
DT Review
DE VacStent; anastomotic insufficiency; endoscopic vacuum therapy;
   gastrointestinal leakage; covered stent; esosponge
AB Anastomotic insufficiencies are severe complications of abdominal surgery, often leading to prolonged hospitalization, serious tissue inflammation, and even sepsis, along with the need for recurrent surgery. Current non-surgical treatments such as self-expanding metal stents (SEMSs) and endoscopic vacuum therapy (EVT) have limitations, including stent migration or perforation. This review evaluates the effectiveness of the VacStent GITM (M & ouml;ller Medical GmbH, Fulda, Germany), a novel medical device combining SEMS and negative-pressure wound therapy in treating gastrointestinal leaks. Data were gathered from four prospective studies and compared with existing treatments. Studies on the VacStent GITM application demonstrate technical success and competitive closure rates in upper gastrointestinal leaks, with minimal complications reported. Comparative analyses with SEMS and EVT reveal promising and most importantly equally good outcomes while maintaining the possibility for sustained enteral nutrition and reducing the risk of stent migration. The VacStent GITM presents a promising alternative to current non-surgical treatments. Ongoing research aims to validate its efficacy in lower gastrointestinal leaks and comprehensively establish its role in leak management. Further investigation is necessary to confirm these findings and optimize treatment protocols. Future usages of the VacStent GITM in colonic anastomotic insufficiencies promise an effective approach and might be able to lower the rates of necessary implementations of a stoma.
C1 [Yohannes, Alexander; Dormann, Arno J.; Huegle, Ulrich] Ctr Interdisciplinary Visceral Med, Dept Gastroenterol Gastrointestinal Oncol Gastroin, Cologne Holweide & Merheim Med Ctr, D-51109 Cologne, Germany.
   [Yohannes, Alexander; Knievel, Judith; Lange, Jonas; Eisenberger, Claus F.; Heiss, Markus M.] Witten Herdecke Univ, Ctr Interdisciplinary Visceral Med, Cologne Merheim Med Ctr, Dept Abdominal Tumour Transplant & Vasc Surg, D-51109 Cologne, Germany.
RP Heiss, MM (通讯作者)，Witten Herdecke Univ, Ctr Interdisciplinary Visceral Med, Cologne Merheim Med Ctr, Dept Abdominal Tumour Transplant & Vasc Surg, D-51109 Cologne, Germany.
EM yohannesa@kliniken-koeln.de; knievelj@kliniken-koeln.de;
   langej@kliniken-koeln.de; dormanna@kliniken-koeln.de;
   huegleu@kliniken-koeln.de; eisenbergercf@kliniken-koeln.de;
   heissm@kliniken-koeln.de
OI Yohannes, Alexander/0009-0001-4562-9924; Knievel,
   Judith/0000-0002-6213-590X
CR [Anonymous], 2023, Instructions for Use VacStent GI TM Esophagus.
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NR 16
TC 3
Z9 4
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUL
PY 2024
VL 14
IS 7
AR 821
DI 10.3390/life14070821
PG 10
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA ZR5E8
UT WOS:001277026800001
PM 39063574
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Levin, LS
AF Levin, L. Scott
TI Principles of Definitive Soft Tissue Coverage With Flaps
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE NWPT/ROCF; flaps; VAC; VAC Therapy
ID SURAL ISLAND FLAP; OPEN TIBIAL FRACTURE; CROSS-LEG FLAP; FASCIOCUTANEOUS
   FLAP; RECONSTRUCTION; ANKLE; FOOT; DEFECTS; MICROSURGERY; MANAGEMENT
AB Despite the emergence of negative pressure Wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) for orthopaedic trauma, vascularized tissue transfer whether it be pedicle, free, or tissue transfer using the operating microscope or as an island, remains the mainstay of soft tissue reconstruction for orthopaedic traumatology. The critisism of microvascular procedures has been that they are lengthy, costly, and required technical expertise to perform. While technical skills are required, microsurgical care has evolved into a routine operation with high degrees of success in experienced hand. The problem that still remains is access to surgeons who are interested in Soft tissue reconstruction and can perform definitive coverage with flaps. There is a need in the orthopaedic community to solve the problem of lack of flap surgeons and as a result, NPWT/ROCF has been touted as the answer to flap reconstruction. NPWT/ROCF is an important addition to soft tissue reconstruction but it serves as a bridge rather than definitive coverage in many hands. Just as wound technology is evolving with tissue substitutes, growth factors and NPWT/ROCF flaps technology continues to advance with new perforator flaps and local regional flaps, particularly the sural flap, coming on line as mainstays of soft tissue reconstruction
C1 [Levin, L. Scott] Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC 27710 USA.
   [Levin, L. Scott] Duke Univ, Med Ctr, Div Plast & Reconstruct Surg, Durham, NC 27710 USA.
C3 Duke University; Duke University
RP Levin, LS (通讯作者)，Duke Univ, Med Ctr, Div Orthopaed Surg, Box 3945, Durham, NC 27710 USA.
EM levin001@mc.duke.edu
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NR 36
TC 20
Z9 23
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S161
EP S166
DI 10.1097/BOT.0b013e318188e2ed
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100008
PM 19034164
DA 2026-07-24
ER

PT J
AU Adao, D
   Maluf, FC
   Martins, GCL
   Neto, RC
   Scalabrini, M
   Del Grande, LD
AF Adao, Diego
   Maluf, Fauze Camargo
   Martins, Gabriela Caetano Lopes
   Neto, Ramiro Colleoni
   Scalabrini, Milton
   Del Grande, Leonardo De Mello
TI Stepwise plication of abdominal mesh technique for open abdomen closure
SO ACTA CIRURGICA BRASILEIRA
LA English
DT Article
DE Abdominal Wound Closure Techniques; Open Abdomen Techniques; Surgical
   Mesh; Negative-Pressure Wound Therapy
ID PRIMARY FASCIAL CLOSURE; ASSISTED WOUND CLOSURE; TRAUMA; EXPERIENCE;
   MANAGEMENT
AB Purpose:To presentthe stepwise plication ofabdominal mesh (SPAM)as a standardized dynamic closure technique that combines mesh-mediated fascial traction with negative pressure wound therapyfor gradual abdominal wall approximation. Methods: In this technical report, we present SPAM for progressive closure of peritoneostomy with excessive abdominal wall retraction. It involves a central mesh incision followed by progressive tightening via hemostatic clamp rotation (similarto opening a can with a key), without full-thickness mesh cut. The mesh is secured with continuous suture and covered with a non-commercial negative pressure system. Cycles are repeated every 48-72 hours until fascial closure. Results: SPAM was applied in four patients: three successful cases (52-year-old male with rectal perforation, 36-year-old female post-Hartmann evisceration, 63-year-old female with gastrojejunal anastomosis leak)achieved primaryfascial closure in a median of 10 days, with well-tolerated traction, no enteroatmosphericfistula, or incisional hernia. In one failure (59-year-old male with gastrojejunal leak post-laparoscopic gastrectomy), bleeding occurred during traction (controlled surgically), yet the technique was discontinued due to progressive clinical deterioration. Conclusion: SPAM offers a practical, standardized, reproducible approach to delayed fascial closure, particularly in resource-limited settings, enabling controlled progressive approximation without mesh resection.
C1 [Adao, Diego; Maluf, Fauze Camargo; Martins, Gabriela Caetano Lopes; Neto, Ramiro Colleoni; Scalabrini, Milton; Del Grande, Leonardo De Mello] Univ Fed Sao Paulo, Dept Cirurgia, Escola Paulista Med, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Adao, D (通讯作者)，Univ Fed Sao Paulo, Dept Cirurgia, Escola Paulista Med, Sao Paulo, Brazil.
EM diego.adao@unifesp.br
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU ACTA CIRURGICA BRASILEIRA
PI SAO PAULO
PA ALAMEDA RIO CLARO, 179-41, SAO PAULO, SP 01332-010, BRAZIL
SN 0102-8650
EI 1678-2674
J9 ACTA CIR BRAS
JI Acta Cir. Bras.
PY 2026
VL 41
AR e413426
DI 10.1590/acb413426
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KW3EI
UT WOS:001817133100001
PM 42384994
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU James, CV
   Murray, Q
   Park, SY
   Khajoueinejad, N
   Lee, JN
   Ray, K
   Lantis, JCL
AF James, Crystal V.
   Murray, Quinn
   Park, So Youn
   Khajoueinejad, Nazanin
   Lee, Jani
   Ray, Keval
   Lantis II, John C.
TI Venous Leg Ulcers: Potential Algorithms of Care br
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE cellular- and tissue-based therapy; fetal bovine dermis; negative
   pressure wound therapy; pentoxifylline; physical therapy; veins; venous
   leg ulcer
ID PRESSURE WOUND THERAPY; DERMAL MATRIX; SKIN-GRAFTS; MANAGEMENT;
   ULCERATION; CLOSURE; COMPRESSION; REFLUX
AB Management of VLUs can be challenging, depending on wound complexity, and may require the use of several treatment modalities to achieve complete wound closure or significant wound area reduction. This review presents a systematic approach to management of VLUs based on previous literature and the authors' clinical experience, with consideration given to wound size, etiology, and responses to prior treatment. Techniques described include debridement (autolytic, enzymatic, sharp/surgical), compression therapy, physical therapy, medical adjuncts, and cellular- and tissue-based therapy. The algorithm of care for VLUs is multimodal. Appropriate diagnostic studies must be performed, including venous duplex and appropriate pathophysiology to confirm the diagnosis of VLU. After the correct diagnosis is confirmed, appropriate treatment may commence. All patients should undergo appropriate wound debridement; the exact modality used is dependent on wound characteristics. Patients must also adhere to consistent compression therapy. Any underlying venous disease that is amenable to surgical intervention should be addressed. Treatment with a medical adjunct and physical therapy are recommended. For patients who do not achieve significant wound area reduction, the addition of CTP is recommended. Use of these methods should result in substantial wound area reduction and/or wound closure.
C1 [James, Crystal V.; Murray, Quinn; Lantis II, John C.] Mount Sinai West Morningside Hosp, Dept Surg, New York, NY USA.
   [Park, So Youn; Khajoueinejad, Nazanin; Lee, Jani; Ray, Keval] Mt Sinai Hosp, Dept Surg, New York, NY USA.
   [James, Crystal V.] Mount Sinai West Med Ctr, 1000 10th Ave, New York, NY 10019 USA.
C3 Icahn School of Medicine at Mount Sinai
RP James, CV (通讯作者)，Mount Sinai West Med Ctr, 1000 10th Ave, New York, NY 10019 USA.
EM Crystal.James2@mountsinai.org
CR AmnioExcel, INTEGRA
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NR 58
TC 5
Z9 8
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD DEC
PY 2022
VL 34
IS 12
BP 288
EP 296
DI 10.25270/wnds/21160
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA A0QV4
UT WOS:000952271300010
PM 36622379
DA 2026-07-24
ER

PT J
AU Knazovicky, M
   Kovác, I
   Romzová, B
   Simon, R
   Katuchová, J
AF Knazovicky, Milos
   Kovac, Ivan
   Romzova, Barbora
   Simon, Robert
   Katuchova, Jana
TI Contemporary management of the open abdomen: standards, challenges, and
   future directions
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Review
DE Open abdomen; Damage control surgery; Temporary abdominal closure;
   Fascial closure; Enteroatmospheric fistula
ID MEDIATED FASCIAL TRACTION; ASSISTED WOUND CLOSURE; ENTEROATMOSPHERIC
   FISTULA; MESH; VACUUM; CLASSIFICATION; METAANALYSIS; MULTICENTER;
   THERAPY; TRAUMA
AB Objective The open abdomen (OA) is a key strategy in damage control surgery (DCS) for severe intra-abdominal pathology but is associated with considerable morbidity, including enteroatmospheric fistula (EAF) and failure of fascial closure. This narrative review summarizes current evidence on indications, temporary abdominal closure (TAC), timing of closure, and supportive care.Methods A structured PubMed/MEDLINE, Embase, Scopus, and Web of Science search was performed up to January 2025 in accordance with PRISMA principles. Relevant systematic reviews, meta-analyses, clinical guidelines, registry analyses, and prospective studies published in English were included. Given the narrative design, no meta-analysis was conducted.Results Negative pressure wound therapy (NPWT) combined with dynamic fascial traction represents a preferred TAC strategy, achieving primary closure rates up to 80-90% in selected patients. Early fascial closure (within 5-7 days) is associated with fewer complications, particularly EAF. Early enteral nutrition (24-48 h), when feasible, may support fascial approximation. However, available evidence is largely observational and heterogeneous, with substantial inter-institutional variability.Conclusion Optimal OA management requires appropriate indication, standardized TAC strategies, and a proactive approach to early closure. When primary closure is not feasible, a planned ventral hernia remains a safe alternative. High-quality prospective studies are needed to strengthen the evidence base.
C1 [Knazovicky, Milos; Simon, Robert; Katuchova, Jana] Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 1, Rastislavova 43, Kosice 04190, Slovakia.
   [Kovac, Ivan] Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 2, Rastislavova 43, Kosice 04190, Slovakia.
   [Romzova, Barbora] Louise Pasteur Univ Hosp, Dept Plast Reconstruct & Aesthet Surg, Kosice, Slovakia.
C3 University of Pavol Jozef Safarik Kosice; University of Pavol Jozef
   Safarik Kosice
RP Kovác, I (通讯作者)，Pavol Jozef Safarik Univ, Louise Pasteur Univ Hosp, Dept Surg 2, Rastislavova 43, Kosice 04190, Slovakia.
EM ivan.kovac@upjs.sk
FU Pavol Jozef Scaron;afrik University in Koscaron;ice
FX Open access funding provided by The Ministry of Education, Science,
   Research and Sport of the Slovak Republic in cooperation with Centre for
   Scientific and Technical Information of the Slovak Republic
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD MAY 12
PY 2026
VL 411
IS 1
AR 184
DI 10.1007/s00423-026-04080-9
EA MAY 2026
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KP2PO
UT WOS:001812340800002
PM 42120816
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Hancock-Allen, JB
   Janelle, SJ
   Lujan, K
   Bamberg, WM
AF Hancock-Allen, Jessica B.
   Janelle, Sarah J.
   Lujan, Kate
   Bamberg, Wendy M.
TI Outbreak of group A Streptococcus infections in an outpatient
   wound clinic-Colorado, 2014
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
DE Disease outbreak; infection; wound infection; epidemiology
ID HEALTH-CARE; TRANSMISSION
AB Background: In September 2014, wound clinic A reported a cluster of group A Streptococcus (GAS) infections to public health authorities. Although clinic providers were individually licensed, the clinic, affiliated with hospital A, was not licensed or subject to regulation. We investigated to identify cases, determine risk factors, and implement control measures.
   Methods: A case was defined as GAS isolation from a wound or blood specimen during March 28-November 19, 2014, from a patient treated at wound clinic A or by a wound clinic A provider within the previous 7 days. All wound clinic A staff were screened for GAS carriage. Wound care procedures were assessed for adherence to infection control principles and possible GAS transmission routes.
   Results: We identified 16 patients with 19 unique infections: 9 (56%) patients required hospitalization, and 7 (44%) required surgical debridement procedures. One patient died. Six (37%) patients received negative pressure wound therapy at GAS onset. Staff self-screening found no GAS carriers. Breaches in infection control and poor wound care practices were widespread.
   Conclusions: This GAS outbreak was associated with a wound care clinic not subject to state or federal regulation. Lapses in infection control practices and inadequate oversight contributed to the outbreak. Published by Elsevier Inc. on behalf of Association for Professionals in Infection Control and Epidemiology, Inc.
C1 [Hancock-Allen, Jessica B.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Sci Educ & Profess Dev, Atlanta, GA USA.
   [Hancock-Allen, Jessica B.; Janelle, Sarah J.; Lujan, Kate; Bamberg, Wendy M.] Colorado Dept Publ Hlth & Environm, Dis Control & Environm Epidemiol Div, 4300 Cherry Creek Dr S, Denver, CO 80246 USA.
C3 Centers for Disease Control & Prevention - USA; CDC Scientific Education
   & Professional Development Program Office (SEDPO); Colorado Department
   of Public Health & Environment
RP Bamberg, WM (通讯作者)，Colorado Dept Publ Hlth & Environm, Dis Control & Environm Epidemiol Div, 4300 Cherry Creek Dr S, Denver, CO 80246 USA.
EM Wendy.Bamberg@state.co.us
CR [Anonymous], GUID INF PREV OUTP S
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NR 17
TC 5
Z9 7
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
EI 1527-3296
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD OCT 1
PY 2016
VL 44
IS 10
BP 1133
EP 1138
DI 10.1016/j.ajic.2016.03.058
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA EE3QP
UT WOS:000389510400013
PM 27307178
DA 2026-07-24
ER

PT J
AU Grauhan, O
   Navasardyan, A
   Tutkun, B
   Hennig, F
   Müller, P
   Hummel, M
   Hetzer, R
AF Grauhan, Onnen
   Navasardyan, Artashes
   Tutkun, Baris
   Hennig, Felix
   Mueller, Peter
   Hummel, Manfred
   Hetzer, Roland
TI Effect of surgical incision management on wound infections in a
   poststernotomy patient population
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Mediastinitis; Poststernotomy infection; Prevena Therapy; Surgical
   incision management; Surgical site infection
ID POSTOPERATIVE MEDIASTINITIS; THERAPY
AB Skin breakdown and infiltration of skin flora are key causative elements in poststernotomy wound infections. We hypothesised that surgical incision management (SIM) using negative pressure wound therapy over closed surgical incisions for 6-7 days would reduce wound infections in a comprehensive poststernotomy patient population. 'All comers' undergoing median sternotomy at our institution were analysed prospectively from 1 September to 15 October 2013 (study group, n=237) and retrospectively from January 2008 to December 2009 (historical control group, n=3508). The study group had SIM ( Prevena (TM) Therapy) placed immediately after skin suturing and applied at -125 mmHg for 6-7 days, whereas control group received conventional sterile wound tape dressings. Primary endpoint was wound infection within 30 days. Study group had a significantly lower infection rate than control group: 1.3% (3 patients) versus 3.4% (119 patients), respectively (P<0.05; odds ratio 2.74). In the study group, when the foam dressing was removed after 6-7 days, the incision was primarily closed in 234 of 237 patients (98.7%). SIM over clean, closed incisions for the first 6-7 postoperative days significantly reduced the incidence of wound infection after median sternotomy. Based on these data SIM may be cost- effective in patients undergoing cardiac surgery.
C1 [Grauhan, Onnen; Navasardyan, Artashes; Tutkun, Baris; Hennig, Felix; Mueller, Peter; Hetzer, Roland] Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, D-13353 Berlin, Germany.
   [Hummel, Manfred] Paulinen Krankenhaus, Dept Internal Med, Berlin, Germany.
C3 German Heart Center Berlin
RP Grauhan, O (通讯作者)，Deutsch Herzzentrum Berlin, Dept Cardiothorac & Vasc Surg, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM Grauhan@dhzb.de
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   DURHAM SJ, 2008, CARDIAC SURG ADULT, P535
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
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   Gelape Cláudio Léo, 2007, Arq. Bras. Cardiol., V89, pe3
   Graf K, 2010, EUR J CARDIO-THORAC, V37, P893, DOI 10.1016/j.ejcts.2009.10.005
   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
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NR 11
TC 62
Z9 71
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2014
VL 11
SU 1
SI SI
BP 6
EP 9
DI 10.1111/iwj.12294
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AJ3MO
UT WOS:000337570900003
PM 24851729
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Godoy-Santos, AL
   Rosemberg, LA
   de Cesar-Netto, C
   Armstrong, DG
AF Godoy-Santos, Alexandre L.
   Rosemberg, Laercio A.
   de Cesar-Netto, Cesar
   Armstrong, David G.
TI The use of bioactive glass S53P4 in the treatment of an infected Charcot
   foot: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bioglass; Charcot foot; osteomyelitis; preservation; principles of
   management
ID DIABETIC FOOT; AMPUTATION; OSTEOMYELITIS; COST; FATE; LEG
AB Objective: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot.
   Case summary: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. We used a multidisciplinary approach to treatment with early antibiotic therapy, tight glycaemic control and staged surgical treatment. Initial treatment was adequate irrigation and debridement, bone-void filling with bioactive glass, external fixation and provisional negative pressure wound therapy (NPWT). Later progressed to total contact casting and progressive protect weight bearing. At final follow-up, patient was full weight-bearing in stiff soled footwear, with no clinical signs of infection, no gross alteration of gait pattern and demonstrating complete bone healing and integration of the bioactive glass.
   Conclusion: The bioactive glass S53P4 was successfully used in the limb-salvage staged treatment of a patient with an infected Charcot foot. Here, full integration with the surrounding bone and its supportive action in the combat of bone infection was demonstrated.
C1 [Godoy-Santos, Alexandre L.] Hosp Israelita Albert Einstein, Dept Orthoped Surg, Sao Paulo, SP, Brazil.
   [Godoy-Santos, Alexandre L.; Rosemberg, Laercio A.] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Ortopedia & Traumatol, Sao Paulo, SP, Brazil.
   [Rosemberg, Laercio A.] Hosp Israelita Albert Einstein, Dept Radiol, Sao Paulo, SP, Brazil.
   [de Cesar-Netto, Cesar] Hosp Special Surg, Dept Orthoped Foot & Ankle, 535 E 70th St, New York, NY 10021 USA.
   [Armstrong, David G.] Univ Southern Calif, Southwestern Acad Limb Salvage Alliance, Keck Sch Med, Dept Surg, Los Angeles, CA USA.
C3 Hospital Israelita Albert Einstein; Universidade de Sao Paulo; Hospital
   Israelita Albert Einstein; University of Southern California
RP Godoy-Santos, AL (通讯作者)，Hosp Israelita Albert Einstein, Dept Orthoped Surg, Sao Paulo, SP, Brazil.; Godoy-Santos, AL (通讯作者)，Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Ortopedia & Traumatol, Sao Paulo, SP, Brazil.
EM alexandrelemegodoy@gmail.com
RI Godoy-Santos, Alexandre/F-7507-2016; de Cesar Netto, Cesar/D-3046-2018
OI Godoy-Santos, Alexandre/0000-0002-6672-1869; de Cesar Netto,
   Cesar/0000-0001-6037-0685
CR Armstrong David G, 2007, Int Wound J, V4, P286
   Armstrong DG, 2017, NEW ENGL J MED, V376, P2367, DOI 10.1056/NEJMra1615439
   Armstrong DG, 1997, J AM PODIAT MED ASSN, V87, P255, DOI 10.7547/87507315-87-6-255
   Aurégan JC, 2015, INJURY, V46, pS3, DOI 10.1016/S0020-1383(15)30048-6
   Barshes NR, 2013, DIABET FOOT ANKLE, V4, DOI 10.3402/dfa.v4i0.21847
   Bosse MJ, 2002, NEW ENGL J MED, V347, P1924, DOI 10.1056/NEJMoa012604
   Fiorito J, 2012, DIABET FOOT ANKLE, V3, DOI 10.3402/dfa.v3i0.18633
   Franklin H, 2014, J REHABIL RES DEV, V51, P1325, DOI 10.1682/JRRD.2013.11.0249
   GOLDNER MG, 1960, DIABETES, V9, P100, DOI 10.2337/diab.9.2.100
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   Kerr M, 2014, DIABETIC MED, V31, P1498, DOI 10.1111/dme.12545
   KUCAN JO, 1986, PLAST RECONSTR SURG, V77, P439, DOI 10.1097/00006534-198603000-00018
   Lauri C, 2017, DIABETES CARE, V40, P1111, DOI 10.2337/dc17-0532
   Lavery LA, 1997, AM J MED, V103, P383, DOI 10.1016/S0002-9343(97)00163-0
   Lindfors NC, 2010, BONE, V47, P212, DOI 10.1016/j.bone.2010.05.030
   Lindfors N, 2017, ADV EXP MED BIOL, V971, P81, DOI 10.1007/5584_2016_156
   Margolis DJ, DATA POINTS PUBLICAT
   Rogers LC, 2011, DIABETES CARE, V34, P2123, DOI 10.2337/dc11-0844
   Short DJ, 2017, CLIN PODIATR MED SUR, V34, P381, DOI 10.1016/j.cpm.2017.02.008
NR 19
TC 10
Z9 12
U1 0
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2019
VL 28
IS 1
SU S
BP S14
EP S17
DI 10.12968/jowc.2019.28.Sup1.S14
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HK3ZQ
UT WOS:000457858900003
PM 30724119
DA 2026-07-24
ER

PT J
AU West, JM
   Jordan, SW
   Mendel, E
   Khan, SN
   Chandawarkar, RY
   Valerio, IL
AF West, Julie M.
   Jordan, Sumanas W.
   Mendel, Ehud
   Khan, Safdar N.
   Chandawarkar, Rajiv Y.
   Valerio, Ian L.
TI Instillation Negative Pressure Wound Therapy: An Effective Tool for
   Complex Spine Wounds
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; VAC with instillation; debridement; infection
ID MANAGEMENT
AB Objective: Infection prevention in spinal surgeries involving implantation of hardware is of utmost priority. Furthermore, successful eradication of infection in hardware salvage is likewise critical in maintaining the long-term retention of the spinal hardware construct.
   Approach: We report a retrospective case series of three cases where the utilization of a VAC with instillation (VACi) in conjunction with surgical debridement aided in infection control and eradication for both preimplantation and hardware salvage spine patients.
   Results: Three patients were included. In case 1, VACi was utilized in conjunction with surgical debridement and IV antibiotics in the setting of acute preoperative infection to eradicate infection and enable necessary spinal hardware implementation. Cases 2 and 3 are representative of VACi for salvage of exposed spinal hardware in both the early and delayed infection presentation settings. In both cases, patients developed postoperative infections following spinal instrumentation VACi was utilized in conjunction with surgical debridement and IV antibiotics. Hardware removal was avoided in both cases. All three patients healed completely without residual evidence of infection.
   Innovation: VACi showed its effectiveness in timely infection eradication before spinal hardware instrumentation and with postoperative spine hardware salvage.
   Conclusion: This case series demonstrates that VACi can provide infection eradication both preoperatively in high-risk surgical sites, facilitating necessary hardware implementation and postoperatively in situations of hardware salvage.
C1 [West, Julie M.; Jordan, Sumanas W.; Chandawarkar, Rajiv Y.; Valerio, Ian L.] Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
   [Mendel, Ehud] Ohio State Univ, Dept Neurosurg, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Mendel, Ehud; Khan, Safdar N.; Chandawarkar, Rajiv Y.; Valerio, Ian L.] Ohio State Univ, Dept Orthoped Surg, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP West, JM (通讯作者)，Ohio State Univ, Dept Plast Surg, Wexner Med Ctr, 915 Olentangy River Rd,Suite 2100, Columbus, OH 43212 USA.
EM Julie.West@osumc.edu
RI Valerio, Ian/F-9161-2017
CR Buck DW, 2014, GRABB SMITHS PLASTIC, P20
   Gage MJ, 2015, ORTHOP CLIN N AM, V46, P227, DOI 10.1016/j.ocl.2014.11.002
   Kapadia BH, 2016, LANCET, V387, P386, DOI 10.1016/S0140-6736(14)61798-0
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Lall RR, 2015, J CLIN NEUROSCI, V22, P238, DOI 10.1016/j.jocn.2014.07.010
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   McConoughey SJ, 2014, FUTURE MICROBIOL, V9, P987, DOI [10.2217/FMB.14.64, 10.2217/fmb.14.64]
   Negosanti L, 2012, DERMATOL THER, V25, P277, DOI 10.1111/j.1529-8019.2012.01451.x
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
NR 9
TC 17
Z9 21
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT
PY 2018
VL 7
IS 10
BP 333
EP 338
DI 10.1089/wound.2018.0793
EA MAY 2018
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GW9GX
UT WOS:000432714900001
PM 30374418
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ruggieri, VG
   Olivier, ME
   Aludaat, C
   Rosato, S
   Marticho, P
   Saade, YA
   Lefebvre, A
   Poncet, A
   Rubin, S
   Biancari, F
AF Ruggieri, Vito Giovanni
   Olivier, Maud-Emmanuelle
   Aludaat, Chadi
   Rosato, Stefano
   Marticho, Paul
   Saade, Yves Assad
   Lefebvre, Annick
   Poncet, Anne
   Rubin, Sylvain
   Biancari, Fausto
TI Negative Pressure versus Conventional Sternal Wound Dressing in Coronary
   Surgery Using Bilateral Internal Mammary Artery Grafts
SO HEART SURGERY FORUM
LA English
DT Article
ID THORACIC ARTERY; THERAPY; LAPAROTOMY; TRIAL
AB Background: Sternal wound infection (SWI) is a major complication occurring often after coronary artery bypass grafting (CABG) using bilateral internal mammary artery (BIMA) grafts. The aim of this study is to assess whether such a risk may be reduced by using incision negative pressure wound therapy (INPWT).
   Methods: Data on patients undergoing isolated CABG using BIMA grafts at the Reims University Hospital, France, from 2013 to 2016 without or with INPWT was prospectively collected.
   Results: INPWT was used in 161 patients and conventional sterile wound dressing was used in 266 patients. Propensity score matching resulted in 128 pairs with similar characteristics. SWIs were similarly distributed between the conventional sterile wound dressing (10.9%) and the INPWT cohorts (10.2%) (P = 1.00). Patients treated with INPWT had a lower rate of deep SWI/mediastinitis than patients who had conventional sterile dressing (5.5% versus 10.2%, P = .210), but the difference did not reach statistical significance. Tests for interaction confirmed these findings in different patient subgroups.
   Conclusion: The routine use of INPWT may not significantly reduce the risk of SWI in patients undergoing BIMA grafting. In view of previous reports showing a benefit with the use of this method, a large randomized study is justified to assess the efficacy of INPWT in patients undergoing cardiac surgery.
C1 [Ruggieri, Vito Giovanni; Olivier, Maud-Emmanuelle; Aludaat, Chadi; Marticho, Paul; Saade, Yves Assad; Rubin, Sylvain] Robert Debre Univ Hosp, Div Cardiovasc & Thorac Surg, Reims, France.
   [Poncet, Anne] Robert Debre Univ Hosp, Unite Anesthesie Reanimat Cardiothorac, Reims, France.
   [Ruggieri, Vito Giovanni; Rubin, Sylvain] URCA, Reims, France.
   [Rosato, Stefano] Ist Super Sanita, Ctr Global Hlth, Rome, Italy.
   [Lefebvre, Annick] CHU Reims, Hop Maison Blanche, Equipe Operat Hyg, Reims, France.
   [Biancari, Fausto] Univ Turku, Turku Univ Hosp, Heart Ctr, Turku, Finland.
   [Biancari, Fausto] Univ Turku, Dept Surg, Turku, Finland.
   [Biancari, Fausto] Univ Oulu, Dept Surg, Oulu, Finland.
C3 Universite de Reims Champagne-Ardenne; CHU de Reims; Universite de Reims
   Champagne-Ardenne; CHU de Reims; Universite de Reims Champagne-Ardenne;
   Istituto Superiore di Sanita (ISS); Universite de Reims
   Champagne-Ardenne; CHU de Reims; University of Turku; University of
   Turku; University of Oulu
RP Ruggieri, VG (通讯作者)，Robert Debre Univ Hosp, Div Cardiovasc & Thorac Surg, Reims, France.
EM vgruggieri@chu-reims.fr
RI ; Rosato, Stefano/LIC-2981-2024; Biancari, Fausto/A-1039-2008
OI aludaat, chadi/0000-0002-9825-3852; Ruggieri, Vito
   Giovanni/0000-0002-2723-8700; Rosato, Stefano/0000-0002-6690-5537;
   Biancari, Fausto/0000-0001-5028-8186
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Deo SV, 2015, INT J SURG, V16, P163, DOI 10.1016/j.ijsu.2015.01.008
   Grauhan O, 2014, INT WOUND J, V11, P6, DOI 10.1111/iwj.12294
   Li PY, 2017, SCAND J SURG, V106, P189, DOI 10.1177/1457496916668681
   Lytle BW, 1999, J THORAC CARDIOV SUR, V117, P855, DOI 10.1016/S0022-5223(99)70365-X
   Manoharan V, 2016, J ARTHROPLASTY, V31, P2487, DOI 10.1016/j.arth.2016.04.016
   Mastrobuoni S, 2012, J THORAC CARDIOV SUR, V144, P874, DOI 10.1016/j.jtcvs.2012.01.022
   Nashef SAM, 2012, EUR J CARDIO-THORAC, V41, P734, DOI 10.1093/ejcts/ezs043
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   PARISH MA, 1992, J THORAC CARDIOV SUR, V104, P1303
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   Shen P, 2017, J AM COLL SURGEONS, V224, P726, DOI 10.1016/j.jamcollsurg.2016.12.028
NR 13
TC 17
Z9 19
U1 0
U2 2
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2019
VL 22
IS 2
BP E92
EP E96
DI 10.1532/hsf.2269
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA HP6XW
UT WOS:000461831600005
PM 31013216
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bollero, D
   Malvasio, V
   Catalano, F
   Stella, M
AF Bollero, Daniele
   Malvasio, Valeria
   Catalano, Fabio
   Stella, Maurizio
TI Negative-pressure surgical management after pathological scar surgical
   excision: a first report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Prevena; Scar; Wound healing
ID CLOSED INCISION MANAGEMENT; WOUND THERAPY; HYPERTROPHIC SCARS;
   PATHOPHYSIOLOGY; INFECTION; SURGERY
AB Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart the suture line. In recent years, a novel negative pressure surgical management system has been developed to prevent surgical wound complications. This system creates a closed environment that removes exudates and other potentially infectious material, protects the surgical site from external contamination, provides support in holding the edges of the incision together and promotes wound healing. In this study, we describe our first experience with Prevena, a closed incision negative pressure management system used on suture line following wide pathological scars excision for the prevention of postoperative wound dehiscence. Eight patients with wide and mature pathological skin scars were treated with Prevena. The device was positioned directly after surgical correction for 8 days with a continuous application of -125 mmHg negative pressure. All treated patients had no postoperative surgical wound dehiscence. In one case, a limit of the device was represented by its poor adherence on hairy surface, hampering the maintenance of an appropriate local negative pressure. In another case, suture line was longer than Prevena foam and it was covered partially. Prevena system appears to be safe, easy to use and may represent a support technique to wide pathological skin scars surgical correction.
C1 [Bollero, Daniele; Malvasio, Valeria; Catalano, Fabio; Stella, Maurizio] CTO Hosp, Burn Ctr, Dept Plast Surg, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino
RP Bollero, D (通讯作者)，CTO Hosp, Burn Ctr, Dept Plast Surg, Turin, Italy.
EM info@danielebollero.it
RI Stella, Maurizio/JGD-2010-2023
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Driver Vickie R, 2004, Ostomy Wound Manage, V50, p11S
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   Greenblatt DY, 2011, J VASC SURG, V54, P433, DOI 10.1016/j.jvs.2011.01.034
   Ibrahim AE, 2011, INT WOUND J, V8, P622, DOI 10.1111/j.1742-481X.2011.00842.x
   Kilpadi DV, 2011, WOUND REPAIR REGEN, V19, P588, DOI 10.1111/j.1524-475X.2011.00714.x
   Kimura A, 2005, J DERMATOL SCI, V40, P205, DOI 10.1016/j.jdermsci.2005.07.007
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   Mustoe TA, 2002, PLAST RECONSTR SURG, V110, P560, DOI 10.1097/00006534-200208000-00031
   Nahas FX, 2007, PLAST RECONSTR SURG, V119, P1060, DOI 10.1097/01.prs.0000242493.11655.68
   Ogawa R, 2010, PLAST RECONSTR SURG, V125, P557, DOI 10.1097/PRS.0b013e3181c82dd5
   Pachowsky M, 2012, INT ORTHOP, V36, P719, DOI 10.1007/s00264-011-1321-8
   Paul M, 2007, J THORAC CARDIOV SUR, V133, P397, DOI 10.1016/j.jtcvs.2006.10.012
   Saleh K, 2002, J ORTHOP RES, V20, P506, DOI 10.1016/S0736-0266(01)00153-X
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   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
   Teshima H, 2009, SURG TODAY, V39, P848, DOI 10.1007/s00595-008-3974-5
   Tziotzios C, 2012, J AM ACAD DERMATOL, V66, P13, DOI 10.1016/j.jaad.2011.08.035
   Verhaegen PDHM, 2011, BURNS, V37, P1222, DOI 10.1016/j.burns.2011.04.018
   Verhaegen PDHM, 2011, PLAST RECONSTR SURG, V127, P1958, DOI 10.1097/PRS.0b013e31820cf4be
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
   Wolfram D, 2009, DERMATOL SURG, V35, P171, DOI 10.1111/j.1524-4725.2008.34406.x
NR 26
TC 19
Z9 22
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 17
EP 21
DI 10.1111/iwj.12040
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700004
PM 23418720
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Crew, JR
   Thibodeaux, KT
   Speyrer, MS
   Gauto, AR
   Shiau, T
   Pang, LLA
   Bley, K
   Debabov, D
AF Crew, John R.
   Thibodeaux, Kerry T.
   Speyrer, Marcus S.
   Gauto, Anibal R.
   Shiau, Timothy
   Pang, Liliana
   Bley, Keith
   Debabov, Dmitri
TI Flow-through Instillation of Hypochlorous Acid in the Treatment of
   Necrotizing Fasciitis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE necrotizing fasciitis; negative pressure; tissue repair
ID PRESSURE WOUND THERAPY; MANAGEMENT; DIAGNOSIS; SUPERANTIGENS
AB Introduction. Necrotizing fasciitis (NF) is a rare and rapidly progressing bacterial infection of soft tissues. Bacterial toxins cause local tissue damage and necrosis, as well as blunt immune system responses. A self-propagating cycle of bacterial invasion, toxin release and tissue destruction can continue until substantial amounts of tissue become necrotic. Neutralization of bacterial toxins should improve the results. Materials and Methods. Pure hypochlorous acid (HOCI) (0.01% w/v) with no sodium hypochlorite impurity in saline pH 4-5, which was recently shown to both eradicate bacteria and neutralize bacterial toxins in vitro, was administered via flow through instillation to 6 patients with NF 4-6 times daily as needed. Utilizing a vacuum -assisted closure, 5-10 mL of pure 0.01% HOCI with no sodium hypochlorite impurity was instilled and removed frequently to irrigate the wounds. Results. Of the 6 patients, no deaths or limb amputations occurred. All infected areas healed completely without major complications. Conclusion. The toxicity and immune dysfunction caused by bacterial toxins and toxins released from damaged cells may be mitigated by flow-through instillation with saline containing pure 0.01% HOCI with no sodium hypochlorite impurity. Randomized controlled clinical trial research of this relatively simple and inexpensive instillation protocol is suggested for identified cases of NE.
C1 [Crew, John R.] Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
   [Thibodeaux, Kerry T.; Speyrer, Marcus S.] Opelousas Gen Hlth Syst, Wound Treatment Ctr LLC, Opelousas, LA USA.
   [Gauto, Anibal R.] Eisenhower Med Ctr, Rancho Mirage, CA USA.
   [Shiau, Timothy; Pang, Liliana; Bley, Keith; Debabov, Dmitri] NovaBay Pharmaceut Inc, Emeryville, CA USA.
RP Crew, JR (通讯作者)，Seton Med Ctr, Wound Care Ctr, 1900 Sullivan Ave, Daly City, CA 94015 USA.
EM jcrewmd@att.net
CR Baharestani MM, 2008, OSTOMY WOUND MANAG, V54, P44
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   Legbo Jacob Ndas, 2005, J Natl Med Assoc, V97, P1692
   Llewelyn M, 2002, LANCET INFECT DIS, V2, P156, DOI 10.1016/S1473-3099(02)00222-0
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   US Centers for Disease Control and Prevention, 2014, NECR FASC RAR DIS ES
   Wang L, 2007, J Burns Wounds, V6, pe5
NR 26
TC 12
Z9 13
U1 0
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2016
VL 28
IS 2
BP 40
EP 47
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DE7QM
UT WOS:000370831800005
PM 26891136
DA 2026-07-24
ER

PT J
AU Atkins, BZ
   Tetterton, JK
   Petersen, RP
   Hurley, K
   Wolfe, WG
AF Atkins, Broadus Zane
   Tetterton, Jean K.
   Petersen, Rebecca P.
   Hurley, Kista
   Wolfe, Walter G.
TI Laser Doppler flowmetry assessment of peristernal perfusion after
   cardiac surgery: beneficial effect of negative pressure therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure; Sub-atmospheric pressure; Surgery; Thoracic; Wound
   healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; BYPASS GRAFT-SURGERY;
   BLOOD-FLOW; RISK-FACTORS; WOUND THERAPY; THORACIC WALL; ARTERY;
   MORTALITY; SURVIVAL
AB Negative pressure therapy has been successfully applied to clean, closed incisions in patients at high-risk for wound complications. Using laser Doppler flowmetry, we evaluated peristernal perfusion after cardiac surgery via median sternotomy, assessing the influence of mammary artery harvesting and the impact of negative pressure therapy. Twenty adult patients underwent median sternotomy for cardiac surgery followed by routine closure. Negative pressure was applied at 125 mm Hg for 4 days postoperatively in patients with increased risk for wound complications (n = 10, negative pressure group); standard dressings were applied to control incisions postoperatively (n = 10). Presternal perfusion was determined at baseline and daily for 4 days postoperatively using laser Doppler flowmetry. Results within and between groups were compared with analysis of variance. No wound complications were encountered in either group. Perfusion increased among the patients who underwent negative pressure therapy and decreased among the controls (P = 0.004). Mammary artery harvesting reduced peristernal perfusion by 25.7% in the controls, but negative pressure increased perfusion by 100% after mammary harvesting (P = 0.04). Negative pressure therapy increased perfusion relative to controls and compensated for reduced perfusion rendered by mammary artery harvesting, providing additional support for 'well wound therapy' in high-risk patients.
C1 [Atkins, Broadus Zane] Durham VA Med Ctr, Dept Surg, Surg Serv, Durham, NC 27705 USA.
   [Atkins, Broadus Zane] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
   [Tetterton, Jean K.; Wolfe, Walter G.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA.
   [Petersen, Rebecca P.] Univ Washington, Dept Surg, Sch Med Seattle, Seattle, WA 98195 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Durham VA Medical Center; Uniformed Services University of the Health
   Sciences - USA; Duke University; University of Washington; University of
   Washington Seattle
RP Atkins, BZ (通讯作者)，Durham VA Med Ctr, Dept Surg, Surg Serv, 112,508 Fulton St, Durham, NC 27705 USA.
EM Broadus.atkins@va.gov
CR ARNOLD F, 1995, BRIT J PLAST SURG, V48, P280, DOI 10.1016/0007-1226(95)90065-9
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   Lucet JC, 2006, INFECT CONT HOSP EP, V27, P1393, DOI 10.1086/509853
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   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
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   Wackenfors A, 2005, ANN THORAC SURG, V79, P1724, DOI 10.1016/j.athoracsur.2004.10.053
   Yuen JC, 2000, PLAST RECONSTR SURG, V105, P55, DOI 10.1097/00006534-200001000-00009
NR 31
TC 49
Z9 54
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2011
VL 8
IS 1
BP 56
EP 62
DI 10.1111/j.1742-481X.2010.00743.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723OD
UT WOS:000287515200006
PM 21167000
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Gallagher, KE
   Alberto, EC
   Getchell, J
   Powell, J
   Cardenas, L
AF Gallagher, Kathy E.
   Alberto, Emily C.
   Getchell, John
   Powell, Jessie
   Cardenas, Luis
TI Expediting Acute Wound Healing by Integrating Multiple Therapeutic
   Strategies: A Case Series
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Acute Wounds; Complex Wounds; Wound Management; Wound Healing; Wound
   Dressings
ID MANAGEMENT
AB BACKGROUND: Traumatic injuries have increased risks for infection and progression to difficult-to-heal wounds. Often, they are inadequately treated with single-purpose dressings. Involving wound care specialists allows for integrating various advanced wound treatments. The objective of this report was to assess if healing rates correlated with using unique combination therapies. METHODS: An observational, prospective analysis was performed, reviewing patients with acute wounds from admission until healed. Systematic assessments were standardized, employing T.I.M.E. (tissue, infection /inflammation, moisture balance, edge/periwound). Key outcomes included wound progression, dimensions, treatments, healing time, and health care utilization metrics. RESULTS: A total of 124 patients with acute wounds up to 1120 cm healed using multimodal therapy. Median time to wound specialist consultation was 2 days. It was 3 determined that all patients were treated with a pure hypochlorous acid-based wound cleanser combined with negative pressure wound therapy, collagen, silver, manuka honey, and/or foam dressings. Median healing time was 19 days. Delays were associated with smoking, immunocompromise, and inability to obtain wound care supplies. CONCLUSIONS: Optimizing advanced therapeutic combinations with innovative dressings, including pHA and other beneficial components, has shown reduced health care utilization of acute wound patients by shortening healing time. The resulting decrease in dressing changes, follow-up appointments, and home care could increase patient satisfaction and improve outcomes.
C1 [Gallagher, Kathy E.; Powell, Jessie; Cardenas, Luis] Christiana Care, Acute Surg Wound Serv, Dept Surg, Newark, DE USA.
   [Gallagher, Kathy E.; Alberto, Emily C.; Getchell, John; Powell, Jessie; Cardenas, Luis] Christiana Care, Dept Surg, Newark, DE USA.
C3 Christiana Care Health System; Christiana Care Health System
RP Gallagher, KE (通讯作者)，2471 Everetts Corner Rd, Hartly, DE 19953 USA.
EM kathy.e.gallagher@gmail.com
CR Alberto EC, 2022, WOUND MANAG PREV, V68, P20, DOI 10.25270/wmp.2022.12.2024
   Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Ennis W, 2020, Vascular News
   Felte R, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.865
   Gallagher KE, 2021, S ADV WOUND CAR OCT
   Khalil H, 2017, INT WOUND J, V14, P1340, DOI 10.1111/iwj.12809
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   Leaper DJ, 2012, INT WOUND J, V9, P1, DOI 10.1111/j.1742-481X.2012.01097.x
   Lindholm C, 2016, INT WOUND J, V13, P5, DOI 10.1111/iwj.12623
   Nussbaum SR, 2018, VALUE HEALTH, V21, P27, DOI 10.1016/j.jval.2017.07.007
   Schubert S, 2022, PHYS MED REH CLIN N, V33, P805, DOI 10.1016/j.pmr.2022.06.006
   Schultz GS, 2003, WOUND REPAIR REGEN, V11, pS1, DOI 10.1046/j.1524-475X.11.s2.1.x
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   Wilkinson HN, 2020, OPEN BIOL, V10, DOI 10.1098/rsob.200223
NR 15
TC 2
Z9 2
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD DEC
PY 2024
VL 70
IS 4
AR 23119
DI 10.25270/wmp.23119
PG 10
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA S7J5R
UT WOS:001399939300005
PM 39788879
DA 2026-07-24
ER

PT J
AU Weissman, JP
   Ramsey, MD
   Ullrich, PJ
   Joshi, CJ
   Garg, S
   Galiano, RD
AF Weissman, Joshua P.
   Ramsey, Matthew D.
   Ullrich, Peter J.
   Joshi, Chitang J.
   Garg, Stuti
   Galiano, Robert D.
TI Injectable Allograft Adipose Matrices in the Management of Chronic and
   Postoperative Wounds: A Retrospective Analysis
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE allograft adipose matrix; chronic wound; diabetes; healing
ID TISSUE
AB Introduction. Clinical options are lacking for the management of chronic wounds or ulcers following failed debridement, skin grafting, or negative pressure wound therapy dressings. Objective. This retrospective case series evaluated the efficacy of injectable AAM in the management and closure of chronic wounds. Materials and Methods. Patients with nonhealing wounds of any etiology, anatomic location, and length of chronicity were included; those with multiple chronic wounds or prior skin grafting for wound repair were excluded. Data on location, etiology, chronicity, and number of AAM applications were collected for each wound. Patients were evaluated for possible complications related to wound healing and infection. Eleven patients (7 males, 4 females), each with 1 chronic wound, were recruited (average age, 65 years). Wound etiologies were postoperative (n = 7), traumatic (n = 2), and foot ulcer (n = 2). Average wound dimensions were 8.45 mm x 7.36 mm, and the average chronicity was 3.77 months. Ten patients received only 1 application of AAM, and 1 patient received 2 treatments 5 days apart. Average follow-up time was 6.6 weeks. Results. Seven patients (63%) achieved wound closure, 4 of which (57%) healed within 1 week of application. Conclusion. Most patients with chronic wounds treated with AAM experienced complete wound closure. AAM shows promising results for enhancing wound healing by providing scaffolding for cell growth.
C1 [Weissman, Joshua P.; Ramsey, Matthew D.; Ullrich, Peter J.; Joshi, Chitang J.; Garg, Stuti; Galiano, Robert D.] Northwestern Univ, Div Plast & Reconstruct Surg, Feinberg Sch Med, Chicago, IL USA.
C3 Northwestern University; Feinberg School of Medicine
RP Galiano, RD (通讯作者)，Northwestern Med, Div Plast & Reconstruct Surg, 675 N St Clair St,Ste 19-250, Chicago, IL 60611 USA.
EM robert.galiano@nm.org
RI ; Garg, Stuti/HLW-7226-2023; Joshi, Chitang/GNW-6650-2022
OI Ramsey, Matthew/0000-0002-7632-4699; 
CR Chen ZY, 2021, J BIOMED MATER RES A, V109, P1418, DOI 10.1002/jbm.a.37133
   Deivasigamani R, 2021, SENSORS-BASEL, V21, DOI 10.3390/s21093007
   Frykberg RG, 2015, ADV WOUND CARE, V4, P560, DOI 10.1089/wound.2015.0635
   Giatsidis G, 2019, PLAST RECONSTR SURG, V144, P884, DOI 10.1097/PRS.0000000000006085
   Gutowski KA, 2009, PLAST RECONSTR SURG, V124, P272, DOI 10.1097/PRS.0b013e3181a09506
   Hanson SE, 2021, PLAST RECONSTR SURG, V147, P1035, DOI 10.1097/PRS.0000000000007827
   Luu CA, 2016, PRS-GLOB OPEN, V4, DOI 10.1097/GOX.0000000000000813
   Mojallal A, 2009, PLAST RECONSTR SURG, V124, P765, DOI 10.1097/PRS.0b013e3181b17b8f
   Olsson M, 2019, WOUND REPAIR REGEN, V27, P114, DOI 10.1111/wrr.12683
   Rigotti G, 2007, PLAST RECONSTR SURG, V119, P1409, DOI 10.1097/01.prs.0000256047.47909.71
   Shahin TB, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001555
   Stasch T, 2015, PLAST RECONSTR SURG, V136, P1357, DOI 10.1097/PRS.0000000000001819
   Zhang QX, 2016, ACTA BIOMATER, V35, P166, DOI 10.1016/j.actbio.2016.02.017
   Zuk PA, 2002, MOL BIOL CELL, V13, P4279, DOI 10.1091/mbc.E02-02-0105
NR 14
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2022
VL 34
IS 10
BP 250
EP 253
DI 10.25270/wnds/21097
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D0QR3
UT WOS:000965863800006
PM 36219711
DA 2026-07-24
ER

PT J
AU Yoon, D
   Yoon, D
   Sim, H
   Hwang, I
   Lee, JS
   Chun, W
AF Yoon, Dajeong
   Yoon, Dogeon
   Sim, Heejoong
   Hwang, Inseok
   Lee, Ji-Seon
   Chun, Wook
TI Accelerated Wound Healing by Fibroblasts Differentiated from Human
   Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer
   Animal Model
SO STEM CELLS INTERNATIONAL
LA English
DT Article
ID INTRACTABLE SKIN ULCERS; GROWTH-FACTOR; EPIDERMOLYSIS-BULLOSA; DERMAL
   SUBSTITUTE; CLINICAL-TRIAL; INTERLEUKIN-6; PROLIFERATION; REGENERATION;
   DERMAGRAFT; CYTOKINES
AB Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. In this study, we tested whether human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) could be differentiated into fibroblasts considering that they have characteristics of high differentiation rates, unlimited proliferation possibility from a single colony, and homogeneity. As a result, hESC-MSC-derived fibroblasts (hESC-MSC-Fbs) showed a significant increase in the expression of type I and III collagen, fibronectin, and fibroblast-specific protein-1 (FSP-1). Besides, vessel formation and wound healing were enhanced in hESC-MSC-Fb-treated skin tissues compared to PBS- or hESC-MSC-treated skin tissues, along with decreased IL-6 expression at 4 days after the formation of pressure ulcer wound in a mouse model. In view of the limited available cell sources for fibroblast therapy, hESC-MSC-Fbs show a promising potential as a commercial cell therapy source to treat skin ulcers.
C1 [Yoon, Dajeong; Yoon, Dogeon; Sim, Heejoong; Hwang, Inseok; Lee, Ji-Seon; Chun, Wook] Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Burn Inst, Seoul, South Korea.
   [Chun, Wook] Hallym Univ, Hangang Sacred Heart Hosp, Coll Med, Dept Surg, Seoul, South Korea.
C3 Hallym University; Hallym University
RP Lee, JS; Chun, W (通讯作者)，Hallym Univ, Coll Med, Hangang Sacred Heart Hosp, Burn Inst, Seoul, South Korea.; Chun, W (通讯作者)，Hallym Univ, Hangang Sacred Heart Hosp, Coll Med, Dept Surg, Seoul, South Korea.
EM jiseon80@gmail.com; chun0414@hallym.or.kr
OI Lee, Ji-Seon/0000-0003-2702-4646
FU National Research Foundation of Korea (NRF) [2017R1A2B4002536,
   NRF-2015R1D1A3A01017832]; Korea Centers for Disease Control and
   Prevention [2018ER610300]
FX This research was supported by a fund from the National Research
   Foundation of Korea (NRF; grant nos. 2017R1A2B4002536 and
   NRF-2015R1D1A3A01017832) and Research of Korea Centers for Disease
   Control and Prevention (2018ER610300).
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NR 49
TC 32
Z9 37
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 4789568
DI 10.1155/2018/4789568
PG 12
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HH5UK
UT WOS:000455793500001
PM 30693037
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Murray, CK
   Hsu, JR
   Solomkin, JS
   Keeling, JJ
   Andersen, RC
   Ficke, JR
   Calhoun, JH
AF Murray, Clinton K.
   Hsu, Joseph R.
   Solomkin, Joseph S.
   Keeling, John J.
   Andersen, Romney C.
   Ficke, James R.
   Calhoun, Jason H.
TI Prevention and management of infections associated with combat-related
   extremity injuries
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Review
DE combat; trauma; extremity; infection
ID OPEN TIBIAL FRACTURES; DELAYED SURGICAL-TREATMENT;
   OPERATION-IRAQI-FREEDOM; HUMERAL SHAFT FRACTURES; PRESSURE WOUND
   THERAPY; EXTERNAL FIXATION; FEMORAL-SHAFT; INTERNAL-FIXATION; DEEP
   INFECTION; WAR WOUNDS
AB Orthopedic injuries suffered by casualties during combat constitute approximately 65% of the total percentage of injuries and are evenly distributed between upper and lower extremities. The high-energy explosive injuries, environmental contamination, varying evacuation procedures, and progressive levels of medical care make managing combat-related injuries challenging. The goals of orthopedic injury management are to prevent infection, promote fracture healing, and restore function. It appears that 2% to 15% of combat-related extremity injuries develop osteomyelitis, although lower extremity injuries are at higher risk of infections than upper extremity. Management strategies of combat-related injuries primarily focus on early surgical debridement and stabilization, antibiotic administration, and delayed primary closure. Herein, we provide evidence-based recommendations from military and civilian data to the management of combat-related injuries of the extremity. Areas of emphasis include the utility of bacterial cultures, antimicrobial therapy, irrigation fluids and techniques, timing of surgical care, fixation, antibiotic impregnated beads, wound closure, and wound coverage with negative pressure wound therapy. Most of the recommendations are not supported by randomized controlled trials or adequate cohorts studies in a military population and further efforts are needed to answer best treatment strategies.
C1 [Murray, Clinton K.; Hsu, Joseph R.; Solomkin, Joseph S.; Keeling, John J.; Andersen, Romney C.; Ficke, James R.; Calhoun, Jason H.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center
RP Murray, CK (通讯作者)，Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Dr, Ft Sam Houston, TX 78234 USA.
EM Clinton.Murray@amedd.army.mil
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NR 143
TC 123
Z9 150
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD MAR
PY 2008
VL 64
IS 3
SU S
BP S239
EP S251
DI 10.1097/TA.0b013e318163cd14
PG 13
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 276SY
UT WOS:000254164300005
PM 18316968
DA 2026-07-24
ER

PT J
AU Kleinhans, M
   Stoffels, I
   Dissemond, J
AF Kleinhans, Monika
   Stoffels, Ingo
   Dissemond, Joachim
TI Long-term healing of a therapy-refractory venous leg ulcer after crural
   fasciectomy and split skin graft transplantation
SO HAUTARZT
LA German
DT Article
DE Chronic wounds; Shave therapy; Crural fasciectomy; Wound bed
   preparation; Mesh graft technique
ID SHAVE-THERAPY; INSUFFICIENCY; FASCIOTOMY; ETIOLOGY
AB A 59-year-old obese woman had been suffering from a painful, chronic leg ulcer since 1986. We diagnosed a venous leg ulcer due to functional chronic venous insufficiency in the context of obesity per magna (dependency syndrome) and arthrogenic congestion syndrome due to immobility. Although a high ligation and stripping of the great saphenous vein and several so-called shave therapies with split skin transplantation after appropriate wound bed preparation had been previously performed, the wound persisted. In 2012, the patient wanted to amputate her leg because the course of wound healing was so refractory to therapy and she suffered from severe pain. As an alternative to amputation, we performed a crural fascietomy and, after a wound bed preparation with two cycles of negative pressure wound therapy, we covered the defect with a split skin graft using the mesh graft technique. The surgery could be performed without complications and the skin healed completely. At the current presentation 7 years after the intervention, complete healing of the previously therapy-refractory venous leg ulcer was shown despite the persistent obesity per magna and immobility. This case report shows that a crural fasciectomy should be considered, especially in the case of otherwise therapy-refractory courses of venous leg ulcers.
C1 [Kleinhans, Monika; Stoffels, Ingo; Dissemond, Joachim] Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Hufelandstr 55, D-45122 Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (通讯作者)，Univ Klinikum Essen, Klin & Poliklin Dermatol Venerol & Allergol, Hufelandstr 55, D-45122 Essen, Germany.
EM joachim.dissemond@uk-essen.de
RI Dissemond, Joachim/AFG-0691-2022
FU Projekt DEAL
FX Open Access funding provided by Projekt DEAL.
CR Garzon K, 2010, VASOMED, V22, P2018
   Göstl K, 2009, PHLEBOLOGIE, V38, P108
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   Schmeller W, 1996, HAUTARZT, V47, P676, DOI 10.1007/s001050050488
NR 10
TC 3
Z9 4
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD FEB
PY 2021
VL 72
IS 2
SI SI
BP 157
EP 162
DI 10.1007/s00105-020-04659-3
EA JUL 2020
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QA2FG
UT WOS:000552917700003
PM 32720166
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Hepa-Banasik, A
   Szatan, M
   Slabon, A
   Lach, J
   Wielgórecki, A
   Czerny-Bednarczyk, K
   Labus, W
AF Hepa-Banasik, Anna
   Szatan, Magdalena
   Slabon, Anna
   Lach, Jaroslaw
   Wielgorecki, Artur
   Czerny-Bednarczyk, Katarzyna
   Labus, Wojciech
TI Holistic Therapy in a Patient with Necrotic Ulcer Caused by the Bite of
   Brazilian Wandering Spider: A Case Report of Challenging Treatment with
   Combined Therapies
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE chronic wound; spider bite; acellular dermal matrix; split thickness
   skin graft; microperfusion
ID MECHANISMS; ADULTS; VENOM
AB Hard-to-heal wounds remain a significant challenge for healthcare professionals, particularly in aging populations. Although most chronic wounds are associated with diabetes or chronic venous insufficiency, rare etiologies should also be considered. One such cause is envenomation by Phoneutria spp. (native to South America, rare in Europe). Their venom contains potent neurotoxins. While systemic manifestations are more commonly reported, localized necrotic skin lesions may also occur. This case report presents a rare chronic wound following a suspected Phoneutria spider bite and highlights the importance of an individualized, multimodal treatment approach. A 61-year-old male patient with a progressive thigh wound following a spider bite sustained during work. Despite initial self-treatment and pharmacotherapy the wound deteriorated. The patient was admitted to the authors' facility, where surgical treatment included necrosectomy and a sandwich graft using an acellular dermal matrix combined with a split-thickness skin graft. Adjunctive therapies included negative pressure wound therapy and hyperbaric oxygen therapy. After discharge, outpatient wound care was continued. Treatment was monitored with photographic documentation and serial microperfusion measurements. Complete wound closure was achieved after 4 months of specialized therapy. Management of chronic wounds requires a multidisciplinary and individualized approach with surgical intervention, advanced wound care and specialized outpatient follow-up.
C1 [Hepa-Banasik, Anna; Szatan, Magdalena; Slabon, Anna; Lach, Jaroslaw; Wielgorecki, Artur; Czerny-Bednarczyk, Katarzyna; Labus, Wojciech] Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla II St 2, PL-41100 Siemianowice Slaskie, Poland.
   [Hepa-Banasik, Anna; Szatan, Magdalena; Slabon, Anna] Med Univ Silesia, Fac Hlth Sci Bytom, Doctoral Sch, PL-41902 Bytom, Poland.
C3 Medical University of Silesia
RP Hepa-Banasik, A; Slabon, A (通讯作者)，Stanislaw Sakiel Burn Treatment Ctr Siemianowice S, Jana Pawla II St 2, PL-41100 Siemianowice Slaskie, Poland.; Hepa-Banasik, A; Slabon, A (通讯作者)，Med Univ Silesia, Fac Hlth Sci Bytom, Doctoral Sch, PL-41902 Bytom, Poland.
EM anna.hepa@clo.com.pl; anna.slabon@clo.com.pl;
   artur.wielgorecki@clo.com.pl; wojciech.labus@clo.com.pl
RI Łabuś, Wojciech/I-3141-2019
OI Łabuś, Wojciech/0000-0003-2108-9270
CR [Anonymous], Polskie Towarzystwo Geriatryczne Cukrzyca u osob w wieku podeszlym. Cz. 1.
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN 15
PY 2026
VL 15
IS 2
AR 693
DI 10.3390/jcm15020693
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO5QJ
UT WOS:001670701500001
PM 41598629
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Alhabsi, AN
   Al Lawati, A
   Al Hashmi, L
   Al-Isaii, F
   Alghammari, A
   Das, S
   Al Hashmi, S
AF Alhabsi, Ayman N.
   Al Lawati, Abdullah
   Al Hashmi, Lubna
   Al-Isaii, Fatema
   Alghammari, Alwaleed
   Das, Srijit
   Al Hashmi, Sheikhan
TI Clinical and Postoperative Applications of Manuka Honey in Wound
   Healing: An Evidence-Based Review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE antibacterial; Manuka honey; methylglycol; wound
ID IMPREGNATED DRESSINGS; GAMMA-RADIATION; CARE; TRIAL; EFFICACY; THERAPY
AB Chronic and postoperative wounds remain challenging to manage, with high risks of infection, delayed healing and increased costs. Manuka honey offers antibacterial, anti-inflammatory, antioxidant and tissue-regenerative properties through methylglyoxal, phenolic compounds, high sugar content and low pH. The main objective is to review the mechanisms, clinical outcomes and applications of Manuka honey in wound care. A narrative review of PubMed, Scopus and Google Scholar identified studies on surgical site management, graft or flap bed preparation, chronic wounds and novel delivery systems, prioritising randomised controlled trials and high-quality observational data. Results have shown that Manuka honey demonstrates broad-spectrum antimicrobial and antibiofilm effects, supports non-traumatic debridement and modulates inflammation to promote granulation and re-epithelialisation. Clinical studies show reduced bacterial load, faster healing and improved comfort in surgical and chronic wounds. Operative uses include pre-grafting bed conditioning, adjunctive treatment for infected wounds and integration with negative pressure wound therapy. Emerging delivery approaches, such as bioengineered honey-collagen dressings and nanofibrous scaffolds, show promise for enhancing postoperative outcomes. To conclude, Manuka honey is a versatile and promising adjunct in modern wound care management. Standardised application protocols and robust, high-quality surgical trials are urgently needed to confirm its effective role in perioperative clinical practice.
C1 [Alhabsi, Ayman N.; Al-Isaii, Fatema; Alghammari, Alwaleed] Royal Coll Surg, Dept Med, Dublin, Ireland.
   [Al Lawati, Abdullah] Sultan Qaboos Univ Hosp, Dept Surg, Muscat, Oman.
   [Al Hashmi, Lubna; Al Hashmi, Sheikhan] Khoula Hosp, Dept Plast Craniofacial & Burn Surg, Muscat, Oman.
   [Das, Srijit] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Human & Clin Anat, Muscat, Oman.
C3 Royal College of Surgeons in Ireland - RCSI; Sultan Qaboos University;
   Sultan Qaboos University
RP Alhabsi, AN (通讯作者)，Royal Coll Surg, Dept Med, Dublin, Ireland.
EM aymanalhabsi@gmail.com
RI ; Das, Srijit/E-8457-2017
OI AL-ISAII, Fatema/0009-0008-1978-7567; 
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NR 89
TC 1
Z9 1
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY 12
PY 2026
VL 23
IS 5
AR e70939
DI 10.1111/iwj.70939
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HT3HG
UT WOS:001762198000001
PM 42117760
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Neiderer, K
   Martin, B
   Hoffman, S
   Jolley, D
   Dancho, J
AF Neiderer, Katherine
   Martin, Billy
   Hoffman, Steven
   Jolley, David
   Dancho, James
TI A Mechanically Powered Negative Pressure Device Used in Conjunction with
   a Bioengineered Cell-based Product for the Treatment of Pyoderma
   Gangrenosum: A Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; pyoderma gangrenosum; negative-pressure wound therapy;
   artificial skin; wounds
AB Pyoderma gangrenosum (PG), an uncommon inflammatory and ulcerative skin disease, typically is treated medically with a combination of immunosuppression and local wound care, but evidence to guide care is limited. PG wounds can be difficult to heal. A 76-year-old male patient presented with a history of rheumatoid arthritis and recalcitrant PG. After 9 months of treatment with local wound care, steroids, and topical tacrolimus, the wound had increased in size from 1.8 cm x 1.5 cm to, 7.2 cm x 5.6 cm. At that time, he was started on a regimen of five applications of a bioengineered cell-based product (one application every 2 weeks for a total of five applications) with twice-weekly mechanically powered negative pressure device changes. The latter was started at 75 mm Hg and changed to 125 mm Hg after 4 weeks, Oral corticosteroid therapy was initially started at 40 mg of prednisone, then slowly tapered to 20 mg, but could not be completely discontinued due to a flare in the patient's rheumatoid symptoms. The wound was completely healed after 16 weeks. Research to ascertain the effectiveness of protocols of PG care, including the combination treatment described, is needed to help clinicians provide evidence-based care for these challenging wounds.
C1 [Neiderer, Katherine; Martin, Billy; Hoffman, Steven; Jolley, David; Dancho, James] Southern Arizona VA Hlth Care Syst, Tucson, AZ 85723 USA.
   [Neiderer, Katherine] Univ Arizona, Tucson, AZ USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Southern Arizona Veterans Affairs Health Care System; University of
   Arizona
RP Neiderer, K (通讯作者)，Southern Arizona VA Hlth Care Syst, Dept Surg, 3601 South 6th Ave 2-112, Tucson, AZ 85723 USA.
EM kateneiderer@hotmail.com
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NR 24
TC 15
Z9 15
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2012
VL 58
IS 9
BP 44
EP 48
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA V30TQ
UT WOS:000208838700007
PM 22933700
DA 2026-07-24
ER

PT J
AU Atlan, M
   Naouri, M
   Lorette, G
   Estève, E
   Zakine, G
AF Atlan, M.
   Naouri, M.
   Lorette, G.
   Esteve, E.
   Zakine, G.
TI Original treatment of constitutional painful callosities by surgical
   excision, collagen/elastin matrix (MatriDerm®) and split thickness skin
   graft secured by negative wound therapy
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Dermal substitute; Collagen-elastin matrix; Constitutionnal painful
   callosities; Palmoplantar keratodermia; Negative pressure wound therapy;
   Skin graft; High resolution ultrasound; Cutometer
ID TERM-FOLLOW-UP; PALMOPLANTAR KERATODERMA; DERMAL SUBSTITUTE; MANAGEMENT;
   SURGERY; INTEGRA; BURNS
AB Constitutional painful callosities is an unusual pathology, integrated in the frame of "palmoplantar keratodermia" (PPK). Lesions are located at areas of support of the sole. These lesions are painful and disable the normal walking. Treatments are suspensive and painkillers. We report our experience of a single surgical treatment: surgical excision, split thickness skin graft applied on a dermal substitute and secured by negative wound therapy. A 28-year-old patient, affected by this disease, has a desire of pregnancy but her treatment is highly teratogen. A year post-op, wounds were healed. The walk was possible with a relief of the pain, without any ulcerations. The surgical treatment by excision and graft or flaps was previously reported for PPK. The use of dermal substitute was never described for this indication. Dermal substitute compensate the thickness of the soft tissue defect and give an accurate quality of elasticity in this localisation. The negative wound therapy enhances the quality and shortens the length of graft taking, and the adhesion of the dermal substitute on his bed. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Atlan, M.; Zakine, G.] CHU Tours, Fac Med Francois Rabelais, Hop Trousseau, Serv Chirurg Plast Reconstructrice & Esthet, F-37044 Tours 9, France.
   [Naouri, M.; Lorette, G.; Esteve, E.] CHRU Tours, Serv Dermatol, F-37044 Tours 9, France.
C3 CHU Tours; CHU Tours
RP Atlan, M (通讯作者)，CHU Tours, Fac Med Francois Rabelais, Hop Trousseau, Serv Chirurg Plast Reconstructrice & Esthet, F-37044 Tours 9, France.
EM mike_atlan@hotmail.com
RI Atlan, Michael/M-5256-2013
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NR 22
TC 6
Z9 7
U1 0
U2 5
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD APR
PY 2011
VL 56
IS 2
BP 163
EP 169
DI 10.1016/j.anplas.2009.11.013
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 749JO
UT WOS:000289461700013
PM 21492759
DA 2026-07-24
ER

PT J
AU Paggiaro, AO
   de Carvalho, VF
   Fonseca, GHH
   Doi, A
   Ferreira, MC
AF Paggiaro, Andre Oliveira
   de Carvalho, Viviane Fernandes
   Fonseca, Guilherme Henrique Hencklain
   Doi, Allison
   Ferreira, Marcus Castro
TI Negative Pressure Therapy for Complex Wounds in Patients with
   Sickle-Cell Disease: A Case Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE sickle-cell anemia; lower leg ulcer; case study; wound healing; negative
   pressure wound therapy
ID LEG ULCERS
AB Sickle-cell disease is the most prevalent genetic disease in the Brazilian population. Lower limb ulcers are the most frequent cutaneous complications, affecting 8% to 10% of the patients. These ulcers are usually deep and may take many years to heal. Evidence about the effectiveness of systemic or topical treatment of these wounds is limited, apart from stabilization of the anemia. A 28-year old woman with sickle-cell disease was admitted for treatment of three deep chronic lower leg ulcers. All wounds had tendon exposure and contained firmly adherent fibrin slough. Following surgical debridement and before grafting, the wounds were managed with three different dressings: a rayon and normal saline solution dressing, a calcium alginate dressing covered with gauze, and negative pressure therapy. All three wounds healed successfully and their grafts showed complete integration; only the rayon-dressed wound required a second debridement. The alginate and rayon-dressed wounds recurred after 9 months and required additional skin grafts. Helpful research on managing ulcers in patients with sickle-cell disease is minimal, but the results of this case study suggest that topical treatment modalities may affect outcomes. Research to explore the safety and effectiveness of NPT in patients with sickle-cell wounds is warranted.
C1 [Ferreira, Marcus Castro] Univ Sao Paulo, Fac Med, Hosp Clin, Div Plast Surg, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP de Carvalho, VF (通讯作者)，Av Dr Arnaldo,455 Room 1363, BR-01246903 Sao Paulo, Brazil.
EM vivianefcarvalho@usp.br
RI Paggiaro, Andr�/F-1570-2016; Carvalho, Viviane/H-9511-2013
OI Carvalho, Viviane/0000-0002-0807-0586
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NR 17
TC 11
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD AUG
PY 2010
VL 56
IS 8
BP 62
EP 67
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 644CO
UT WOS:000281348300013
PM 20729564
DA 2026-07-24
ER

PT J
AU Ahmadzada, S
   Rao, A
   Ghazavi, H
AF Ahmadzada, Sejad
   Rao, Amshuman
   Ghazavi, Hossein
TI Necrotizing fasciitis of the face: current concepts in cause, diagnosis
   and management
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE deep neck infection; face abscess; necrotizing fasciitis
ID SOFT-TISSUE INFECTIONS; SURGICAL DEBRIDEMENT; NECK; HEAD;
   RECONSTRUCTION; CT
AB Purpose of review Necrotizing fasciitis of the face is uncommon but potentially life threatening. With adequate multidisciplinary treatment, mortality and has significantly improved. This article highlights current concepts and supporting literature in the management of facial necrotizing fasciitis. Recent findings Management of necrotizing fasciitis involving the face requires a multisciplinary team approach, including early medical and surgical intervention. With early haemodynamic support, broad spectrum antibiotics and aggressive surgical debridement, mortality has reduced significantly. Soft-tissue reconstruction can be effectively utilized once the infection has been adequately treated. Although some adjunctive treatment such as vacuum assisted closure dressing has shown to be of benefit, other treatments such as hyperbaric oxygen remains controversial. Necrotizing fasciitis is an aggressive soft tissue involving that rapidly spreads along fascial planes. Necrotizing fasciitis involving the face is rare owing to its rich blood supply but is also difficult to manage due to the complex regional anatomy. Common sources are odontogenic, sinugenic, peritonsillar or salivary gland infections and often polymicrobial. The principles of treatment include early and aggressive haemodynamic support, broad spectrum antibiotics and aggressive surgical debridement. Often times repeat debridements following close monitoring is required. Reconstructive options are viable only after the infection has been adequately treated. Although mortality has significantly improved, mediastinal involvement, multiple comorbidities and delayed treatment confers a worse prognosis.
C1 [Ahmadzada, Sejad; Rao, Amshuman] Univ Sydney, Sydney, NSW, Australia.
   [Ahmadzada, Sejad; Rao, Amshuman; Ghazavi, Hossein] John Hunter Hosp, Dept Otolaryngol, Lookout Rd, New Lambton Hts, NSW 2305, Australia.
C3 University of Sydney; John Hunter Hospital
RP Ghazavi, H (通讯作者)，John Hunter Hosp, Dept Otolaryngol, Lookout Rd, New Lambton Hts, NSW 2305, Australia.
EM h.ghazavi@gmail.com
OI Rao, Ahuman/0009-0006-5124-3346
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NR 48
TC 11
Z9 18
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD AUG
PY 2022
VL 30
IS 4
BP 270
EP 275
DI 10.1097/MOO.0000000000000820
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 3J0CS
UT WOS:000833073900014
PM 35906981
DA 2026-07-24
ER

PT J
AU Yao, Z
   Tian, WL
   Xu, X
   Zhao, RS
   Huang, M
   Zhao, YZ
   Chen, XH
AF Yao, Zheng
   Tian, Weiliang
   Xu, Xin
   Zhao, Risheng
   Huang, Ming
   Zhao, Yunzhao
   Chen, Xinhao
TI The Double-Lumen Irrigation-Suction Tube in The Management of Incisional
   Surgical Site Infection After Enterocutaneous Fistula Excisions: An
   Observational Study
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE Management; surgical site infection; enterocutaneous fistula;
   double-lumen irrigation-suction tube; excisions; observational study
ID PRESSURE WOUND THERAPY; COST; PREVENTION; DRAINAGE; SURGERY; CLOSURE;
   TROCAR; RATES
AB Background: This study aimed to investigate the effect of double-lumen irrigation-suction tube (DLIST) in the management of surgical site infections (SSIs) after enterocutaneous fistula (ECF) excisions. Method: From January 2016 to December 2017 medical records of patients with ECF excisions were reviewed. Patients with primary superficial SSI were divided into group a (treated with DLIST) and b (treated with delayed primary closures). Patients with primary deep SSI were divided into group A (treated with DLIST) and B (treated with vacuum-assisted closure [VAC]). The effect of the DLIST was evaluated. Results: There were 32 in group a and 27 in group b. The therapeutic time and cost in group a were lower (13.13 +/- 2.37 d vs. 24.89 +/- 7.44 d; p < .001; $1456 +/- 302 vs.$2784 +/- 583; p < .001). There were 21 in group A and 23 in group B. While the therapeutic time of group A was longer, the cost was lower ($1717 +/- 404 vs. $2636 +/- 592; p < .001). Conclusions: Placing DLIST is an effective and cheap method to treat superficial SSI after ECF excisions. The cost of DLIST in treatment of deep SSI is lower, while the effect of VAC is better.
C1 [Yao, Zheng; Xu, Xin; Zhao, Risheng; Huang, Ming; Chen, Xinhao] Jiangning Hosp, Dept Gen Surg, Hushan Rd 169, Nanjing, Jiangsu, Peoples R China.
   [Tian, Weiliang; Zhao, Yunzhao] Jinling Hosp, Dept Gen Surg, Zhongshan Rd 305 East, Nanjing, Jiangsu, Peoples R China.
RP Zhao, RS (通讯作者)，Jiangning Hosp, Dept Gen Surg, Hushan Rd 169, Nanjing, Jiangsu, Peoples R China.; Zhao, YZ (通讯作者)，Jinling Hosp, Dept Gen Surg, Zhongshan Rd 305 East, Nanjing, Jiangsu, Peoples R China.
EM Dr_zhaorisheng@163.com; Dr_zhaoyunzhao@163.com
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NR 27
TC 9
Z9 10
U1 1
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD AUG 9
PY 2021
VL 34
IS 7
BP 791
EP 797
DI 10.1080/08941939.2019.1693667
EA DEC 2019
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SS3OL
UT WOS:000500425000001
PM 31795782
DA 2026-07-24
ER

PT J
AU Bloemen, MCT
   van der Wal, MBA
   Verhaegen, PDHM
   Nieuwenhuis, MK
   van Baar, ME
   van Zuijlen, PPM
   Middelkoop, E
AF Bloemen, Monica C. T.
   van der Wal, Martijn B. A.
   Verhaegen, Pauline D. H. M.
   Nieuwenhuis, Marianne K.
   van Baar, Margriet E.
   van Zuijlen, Paul P. M.
   Middelkoop, Esther
TI Clinical effectiveness of dermal substitution in burns by topical
   negative pressure: A multicenter randomized controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; RECONSTRUCTIVE SURGERY;
   SUBJECTIVE EVALUATION; WOUND THERAPY; FOLLOW-UP; DEVICE; SURVIVAL;
   INTEGRA; RELIABILITY
AB Previous research has shown clinical effectiveness of dermal substitution; however, in burn wounds, only limited effect has been shown. A problem in burn wounds is the reduced take of the autograft, when the substitute and graft are applied in one procedure. Recently, application of topical negative pressure (TNP) was shown to improve graft take. The aim of this study was to investigate if application of a dermal substitute in combination with TNP improves scar quality after burns. In a four-armed multicenter randomized controlled trial, a split-skin graft with or without a dermal substitute and with or without TNP was compared in patients with deep dermal or full-thickness burns requiring skin transplantation. Graft take and rate of wound epithelialization were evaluated. Three and 12 months postoperatively, scar parameters were measured. The results of 86 patients showed that graft take and epithelialization did not reveal significant differences. Significantly fewer wounds in the TNP group showed postoperative contamination, compared to other groups. Highest elasticity was measured in scars treated with the substitute and TNP, which was significantly better compared to scars treated with the substitute alone. Concluding, this randomized controlled trial shows the effectiveness of dermal substitution combined with TNP in burns, based on extensive wound and scar measurements.
C1 [Bloemen, Monica C. T.; van der Wal, Martijn B. A.; Verhaegen, Pauline D. H. M.; Nieuwenhuis, Marianne K.; van Baar, Margriet E.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Assoc Dutch Burn Ctr, NL-1940 EA Beverwijk, Netherlands.
   [Bloemen, Monica C. T.; van der Wal, Martijn B. A.; Verhaegen, Pauline D. H. M.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Red Cross Hosp, Burn Ctr, Beverwijk, Netherlands.
   [van der Wal, Martijn B. A.; van Zuijlen, Paul P. M.; Middelkoop, Esther] Vrije Univ Amsterdam, Med Ctr, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands.
   [Verhaegen, Pauline D. H. M.; van Zuijlen, Paul P. M.] Red Cross Hosp, Dept Plast Reconstruct & Hand Surg, Beverwijk, Netherlands.
   [Nieuwenhuis, Marianne K.] Martini Hosp, Burn Ctr, Groningen, Netherlands.
   [van Baar, Margriet E.] Maasstad Hosp, Burn Ctr, Rotterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Martini Hospital; Maasstad Hospital
RP Middelkoop, E (通讯作者)，Assoc Dutch Burn Ctr, Postbus 1015, NL-1940 EA Beverwijk, Netherlands.
EM e.middelkoop@vumc.nl
RI van Zuijlen, Paul/AAE-4670-2020; Middelkoop, Esther/M-3735-2014;
   nieuwenhuis, marianne/HJA-0658-2022; van Baar, Margriet/AAG-4219-2021
OI van Zuijlen, Paul/0000-0003-3461-8848; Middelkoop,
   Esther/0000-0001-8843-1080; nieuwenhuis, marianne/0000-0001-5632-3333; 
FU Dutch Burns Foundation [07.109]
FX This research was supported by a grant from the Dutch Burns Foundation
   (grant number 07.109). No financial support was received from the
   producers of the tested materials. None of the authors had a conflict of
   interest.
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NR 40
TC 69
Z9 81
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2012
VL 20
IS 6
BP 797
EP 805
DI 10.1111/j.1524-475X.2012.00845.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 031ZA
UT WOS:000310680200003
PM 23110478
DA 2026-07-24
ER

PT J
AU Windhofer, C
   Karlbauer, A
   Papp, C
AF Windhofer, Christian
   Karlbauer, Alois
   Papp, Christoph
TI Bone, Tendon, and Soft Tissue Reconstruction in One Stage With the
   Composite Tensor Fascia Lata Flap
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE TFL flap; composite; bone; tendon; and soft tissue reconstruction; one
   stage; osteomyelitis; posttraumatic
ID TOTAL KNEE ARTHROPLASTY; LOWER-EXTREMITY; EXTENSOR MECHANISM; DEFECTS;
   GRAFT; TIBIA; OSTEOMYELITIS; COMPLICATIONS; MANAGEMENT; FRACTURES
AB A 46-year-old patient sustained a dia-infracondylar tibial fracture after a ski accident. Open reduction and internal fixation (ORIF) was carried out. After an initially uneventful postoperative course the patient was readmitted because of local and systemic infection signs. Radical surgical debridement was carried out following by Vacuum-Assisted Closure (VAC) therapy. The resulting defect consisted of bone defect of the tibia tuberosity, and complete loss of the patellar tendon and the overlying soft tissue. Reconstruction was carried out with a combined tensor fascia lata (TFL) flap including the TFL muscle with the ilio-tibial tract, vascularized part of the iliac crest and the overlying soft tissue. Bone healing took place without signs of osteomyelitis recurrence, and full weight bearing was possible 4 months after reconstruction. Successful reconstruction of the patellar tendon using the ilio-tibial tract, enables the patient full active knee joint motion. The soft tissue coverage shows stable conditions. The donor site showed inconspicuous healing without pain and normal range of motion of the hip joint. So this composite TFL flap is an interesting flap not only for defects following trauma, but also for combined defects following extensive infections after knee implants.
C1 [Windhofer, Christian; Papp, Christoph] Hosp Barmherzigen Bruder, Dept Plast & Reconstruct Surg, A-5020 Salzburg, Austria.
   [Karlbauer, Alois] AUVA Traumaclin Salzburg, Salzburg, Austria.
C3 Konventhospital Der Barmherzigen Bruder
RP Windhofer, C (通讯作者)，Hosp Barmherzigen Bruder, Dept Plast & Reconstruct Surg, Kajetanerpl 1, A-5020 Salzburg, Austria.
EM windhofer@utanet.at
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NR 30
TC 4
Z9 6
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2009
VL 62
IS 6
BP 665
EP 668
DI 10.1097/SAP.0b013e31817e9c0f
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 451CD
UT WOS:000266447400021
PM 19461282
DA 2026-07-24
ER

PT J
AU Duckworth, WC
   Fawcett, J
   Reddy, S
   Page, JC
AF Duckworth, WC
   Fawcett, J
   Reddy, S
   Page, JC
TI Insulin-degrading activity in wound fluid
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; GROWTH-FACTORS;
   RESISTANCE; METALLOPROTEINASES; ACCELERATION; DEGRADATION; REPAIR
AB Patients with diabetes are at great risk of developing lower extremity ulcers. The management of diabetic foot ulcers typically includes early recognition and appropriate clinical care. Recent advances in wound treatment include topical growth factor therapy, which has been successful in diabetic wounds. Growth factors are decreased in wound fluid; this may be due to decreased supply, increased binding, or increased degradation of the naturally occurring growth factors. This study investigates the activity of the insulin-degrading enzyme in wound fluid. Wound fluid was obtained from patients with (n = 17) and without (n = 4) diabetes. Insulin degradation was assayed by incubating [I-125] insulin with wound fluid and precipitation in trichloroacetic acid. Fluid from nondiabetics degraded 2.22 +/- 0.73%, whereas diabetic fluid degraded significantly more (6.13 +/- 1.48%; P < 0.05). In patients with diabetes, the degradation of insulin by wound fluid correlated with glucose control (hemoglobin A(1c); r(2) = 0.5353; P < 0.001), and patients with worse outcomes (i.e. amputation) had higher wound fluid insulin degradation. The biochemical characteristics of insulin degradation in the wound fluid were consistent with the characteristics of insulin-degrading enzyme. These data suggest that glucose control is a critical factor in wound healing, but a reduction in the insulin-degrading activity in the wound fluid is also a potential therapeutic target.
C1 Carl T Hayden Vet Affairs Med Ctr, Phoenix, AZ 85012 USA.
RP Duckworth, WC (通讯作者)，Carl T Hayden Vet Affairs Med Ctr, CS111E,650 E Indian Sch Rd, Phoenix, AZ 85012 USA.
OI Fawcett, Janet/0009-0008-8987-4981
CR [Anonymous], NIH PUBL
   [Anonymous], NIH PUBLICATION
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NR 35
TC 29
Z9 40
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD FEB 1
PY 2004
VL 89
IS 2
BP 847
EP 851
DI 10.1210/jc.2003-031371
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 771AT
UT WOS:000188763900060
PM 14764804
OA Bronze
DA 2026-07-24
ER

PT J
AU Geller, DS
   Hornicek, FJ
   Mankin, HJ
   Raskin, KA
AF Geller, David S.
   Hornicek, Francis J.
   Mankin, Henry J.
   Raskin, Kevin A.
TI Soft tissue sarcoma resection volume associated with wound-healing
   complications
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Musculoskeletal-Tumor-Society
CY JUN 08-10, 2006
CL Key West, FL
SP Musculoskeletal Tumor Soc
ID VACUUM-ASSISTED CLOSURE; EXTREMITY SARCOMAS; RADIOTHERAPY; SURGERY;
   THERAPY; SALVAGE; RECONSTRUCTION; NEOPLASMS; FLAP
AB Limb-salvage surgery has become the standard of care for most soft tissue sarcomas. While primary closure is often possible, it is frequently complicated by wound-healing complications in the setting of previously irradiated tissue and surgical wounds closed under tension. We sought to identify a relationship between the volume of resected soft tissue and the rate of wound-healing complications. We retrospectively reviewed 108 patients who were treated over a 17-month period for soft-tissue sarcomas using limb-salvage methods. Of these, 87 patients were treated with primary wound closure and 21 patients underwent primary muscle flap closure at the time of wide surgical excision. Of the 87 patients treated with primary wound closure, the mean volume of resected tissue in the group with wound-healing complications was greater than that the group that healed without complications. The mean volume of resected tissue in the group with wound-healing complications was 919 cm(3) +/- 1173 cm(3) and the mean volume of resected tissue in the group without wound-healing complications was 456 cm(3) +/- 704 cm(3). Mean volume of resected tissue in the group of patients treated with primary flap coverage was 1908 cm(3), over twice as large as the mean volume of resected tissue in the group of patients treated with primary closure.
C1 Montefiore Med Ctr, Albert Einstein Coll Med, Orthopaed Oncol Serv, Bronx, NY 10467 USA.
   Harvard Univ, Massachusetts Gen Hosp, Sch Med, Orthopaed Oncol Serv, Boston, MA 02115 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Geller, DS (通讯作者)，Montefiore Med Ctr, Albert Einstein Coll Med, Orthopaed Oncol Serv, 3400 Bainbridge Ave,6th Floor, Bronx, NY 10467 USA.
EM gellerdavid@aol.com
OI Hornicek, Francis/0000-0002-6916-8042
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NR 23
TC 54
Z9 62
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-921X
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD JUN
PY 2007
IS 459
BP 182
EP 185
DI 10.1097/BLO.0b013e3180514c50
PG 4
WC Orthopedics; Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 176KZ
UT WOS:000247085300030
PM 17452922
DA 2026-07-24
ER

PT J
AU Zhang, Y
   Wang, TL
   Liu, Y
   Dong, JS
   Yang, JF
   Xu, H
AF Zhang, Yi
   Wang, Tingliang
   Liu, Ying
   Dong, Jiasheng
   Yang, Jiafei
   Xu, Hua
TI Comparison of Negative Pressure Dressing and Conventional Dressing in
   the Management of Skin Grafts at the Donor Site of the Latissimus Dorsi
   Flap
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE latissimus dorsi flap; donor site complication; seroma formation;
   negative pressure dressing; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; BREAST RECONSTRUCTION;
   PREVENTING SEROMA; MORBIDITY; HARVEST
AB Introduction. Delayed and incomplete healing of the skin graft at the donor site of an LD flap is common because of seroma formation. The authors aimed to evaluate whether the application of an NPD could improve the healing process after STSG at LD donor sites. Materials and Methods. From July 2019 to September 2021, 32 patients underwent STSG with NPD at the LD donor site, and 27 patients underwent STSG with TBDs. Data were collected and analyzed using the chi-square test, t test, and Spearman correlation test. Results. The overall Spearman correlations of graft loss with seroma, hematoma, and infection were 0.56 (P <.01), 0.64 (P <.01), and 0.70 (P <.01), respectively. Compared with the TBD group, the STSG take rate was significantly higher in the NPD group (90.3% vs 84.5%, P =.046) while the seroma rate (18.8% vs 44.4%, P =.033), graft loss (9.4% vs 29.6%, P =.047), and mean length of stay (10.9 +/- 1.8 vs 12.1 +/- 2.4, P =.037) were significantly lower. Conclusions. NPDs for STSG at the LD donor site contribute significantly to improved graft acceptance with reduced seroma formation.
C1 [Zhang, Yi; Wang, Tingliang; Liu, Ying; Dong, Jiasheng; Yang, Jiafei; Xu, Hua] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Shanghai, Peoples R China.
   [Xu, Hua] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Xu, H (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM drxuhua9y@aliyun.com
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NR 27
TC 5
Z9 5
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2023
VL 35
IS 1
BP E69
EP E73
DI 10.25270/wnds/22055
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA H5DI1
UT WOS:000996162500014
PM 37018743
DA 2026-07-24
ER

PT J
AU Ciuntu, BM
   Georgescu, SO
   Cirdeiu, C
   Timofte, D
   Azoicai, D
   Tecuceanu, A
   Moraru, DC
   Schaas, C
   Blaj, M
   Tamas, C
AF Ciuntu, Bogdan Mihnea
   Georgescu, Stefan Octavian
   Cirdeiu, Ciprian
   Timofte, Daniel
   Azoicai, Doina
   Tecuceanu, Angela
   Moraru, Dan Cristian
   Schaas, Carmina
   Blaj, Mihaelau
   Tamas, Camelia
TI Negative Pressure Therapy in Wounds Surgical Treatment
SO REVISTA DE CHIMIE
LA English
DT Article
DE negative pressure; wounds treatment
ID EXPERIMENTAL DIABETES-MELLITUS
AB The study aims to assess the significance of negative pressure therapy in the treatment of 1 January 2014 31 June 2017. The objectives intend to evaluate the healing time required after applying the method and the functional consequences for the patient. A prospective study was conducted on a sample of 31 patients with various tipe of wounds which were monitored their clinical course between September 2014- February 2017, following negative pressure therapy. There were used vacuum assisted closure devices (VAC (TM) Hartman) in order to apply negative pressure to the wound, while complying with specified settings in accordance with patients' outcome. Healing was obtained in all cases, to an average hospital stay of 30 days and 12 days of therapy application. The negative result of microbial cultures was obtained after an average of 7.55 days by simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. After basic treatment of the wound, auxiliary methods such as negative pressure contribute to the healing. Evolution was favorable with wound granulation in 95% cases, which allowed surgery under local anesthesia, and defect was covered with skin graft. VAC therapy falls into the last group of treatments by eliminating healing inhibitors. This regenerates the wound in a damp environment and essentially turns an open wound into a closed system.
C1 [Ciuntu, Bogdan Mihnea; Georgescu, Stefan Octavian; Cirdeiu, Ciprian; Timofte, Daniel] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.
   [Azoicai, Doina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Prevent Med & Inderdisciplinar, 16 Univ Str, Iasi 700115, Romania.
   [Tecuceanu, Angela; Moraru, Dan Cristian; Tamas, Camelia] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Plast & Reconstruct Surg Clin, 16 Univ Str, Iasi 700115, Romania.
   [Schaas, Carmina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Obstet & Gynecol Cuza Voda Hosp Iasi, 16 Univ Str, Iasi 700115, Romania.
   [Blaj, Mihaelau] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Anesthesia & Intens Care, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Ciuntu, BM (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Dept Surg, 16 Univ Str, Iasi 700115, Romania.; Tamas, C (通讯作者)，Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Plast & Reconstruct Surg Clin, 16 Univ Str, Iasi 700115, Romania.
EM bogdanmciuntu@yahoo.com; camelia6ta@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; AZOICAI, DOINA/HDO-6161-2022; Timofte,
   Daniel/AAE-2511-2019; Tamas, Camelia/IAO-9797-2023
OI AZOICAI, DOINA/0000-0003-0423-4085; Timofte, Daniel/0000-0002-6604-874X;
   
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NR 16
TC 7
Z9 7
U1 0
U2 14
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD NOV
PY 2017
VL 68
IS 11
BP 2687
EP 2690
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FO3RW
UT WOS:000416751800046
DA 2026-07-24
ER

PT J
AU Cozzaglio, L
   Farinella, E
   Coladonato, M
   Sciannameo, F
   Gennari, L
   Doci, R
AF Cozzaglio, Luca
   Farinella, Eriberto
   Coladonato, Massimiliano
   Sciannameo, Francesco
   Gennari, Leandro
   Doci, Roberto
TI Current role of surgery in the treatment of digestive fistulas
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article; Proceedings Paper
CT Symposium on the Treatment of Cancer of the Subperitoneal Rectum
CY APR 03-04, 2009
CL Bergamo, ITALY
DE Digestive fistulas; Surgery; Therapy
ID POSTOPERATIVE ENTEROCUTANEOUS FISTULAS; VACUUM-ASSISTED CLOSURE;
   ABDOMINAL-WALL DEFECTS; SMALL-BOWEL FISTULAS; SURGICAL-MANAGEMENT; OPEN
   ABDOMEN; GASTROINTESTINAL FISTULAS; CONSERVATIVE MANAGEMENT; ENTERIC
   FISTULAS; INTESTINAL FISTULIZATION
AB Surgery is the main treatment of digestive fistulas (DF) but its role has changed over the last 40 years The aim of this review is to analyze the surgical management of DF paying attention to timing and type of surgery
   METHODS We performed a review considering the following electronic databases Medline, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, EMBASE and the reference lists of the key papers Literature searches were carried out using the following medical subject headings "digestive fistula", "gastrointestinal fistula", "enterocutaneous fistula", "AND surgery", "AND surgical treatment" Because the absence of randomized studies, we have considered the larger series or original techniques
   RESULTS Surgical treatment of DF has two indications to treat complications due to DF juice action such as peritonitis, abscesses, gangrene, bleeding, and when a fistula fails to heal In this case the surgical indication is often difficult to establish, because of the risk of making an inconclusive act
   CONCLUSIONS Indications to surgery, timing and choice of operation cannot often be standardized because they depend on a mixture of DF and patient characteristics In specific cases, Involvement of nutritionist and plastic surgeon is required
C1 [Cozzaglio, Luca; Coladonato, Massimiliano; Gennari, Leandro; Doci, Roberto] IRCCS Ist Clin Humanitas, Dept Surg Oncol, I-20089 Rozzano Milano, Italy.
   [Farinella, Eriberto; Sciannameo, Francesco] Univ Perugia, Dept Gen & Emergency Surg, S Maria Hosp, I-06100 Perugia, Italy.
C3 IRCCS Humanitas Research Hospital; University of Perugia
RP Cozzaglio, L (通讯作者)，IRCCS Ist Clin Humanitas, Dept Surg Oncol, Via Manzoni 56, I-20089 Rozzano Milano, Italy.
RI Cozzaglio, Luca/AEE-9807-2022
OI Cozzaglio, Luca/0000-0001-5068-9721
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NR 95
TC 5
Z9 5
U1 0
U2 2
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD JUL-AUG
PY 2010
VL 81
IS 4
BP 285
EP 294
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 690DY
UT WOS:000284983900009
PM 21319701
DA 2026-07-24
ER

PT J
AU Hatipoglu, E
   Demiryas, S
   Simsek, O
   Saribeyoglu, K
   Pekmezci, S
AF Hatipoglu, Engin
   Demiryas, Suleyman
   Simsek, Osman
   Saribeyoglu, Kaya
   Pekmezci, Salih
TI Fournier's gangrene: Five years' experience from a single center in
   Turkey
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Fournier's gangrene; prognosis; surgical debridement; treatment
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB BACKGROUND: Is the present study aims to analyze demographic, clinical and surgical data of all patients with FG (Fournier's gangrene) admitted to a tertiary healthcare hospital in the largest city of Turkey.
   METHODS: This study included 35 patients with Fournier's gangrene, who were followed by the General Surgery, Plastic Surgery, and Urology Departments of Istanbul University Cerrahpasa Faculty of Medicine from January 2010 to January 2015. Demographic and clinical data, including gender, age, length of stay at the hospital, the underlying cause(s), number of debridement, predisposing factors, and surgical reconstructive data over 10 years were assessed and analyzed retrospectively.
   RESULTS: The mean age of the 35 patients was 58.14 +/- 12.71 years. Diabetes mellitus was present in 20 of the 35 (57.1%) patients. Twelve of the patients (34.2%) were hospitalized in the intensive care unit (ICU). Length of stay in the ICU was found to be significantly influenced by age, hematocrit level, FGSI and UFGSI (p=0.013, p=0.030 p=0.025 and p=0.002, respectively).
   CONCLUSION: Fournier's gangrene is a fulminant infection with a high mortality rate. Physical examination and anamnesis are quite important for the diagnosis of FG. DM is the most common comorbidity. Age, hematocrit level, FGSI and UFGSI scores affect the patients' length of stay in the ICU.
C1 [Hatipoglu, Engin; Demiryas, Suleyman; Simsek, Osman; Saribeyoglu, Kaya; Pekmezci, Salih] Istanbul Univ Cerrahpasa, Dept Gen Surg, Cerrahpasa Fac Med, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa
RP Hatipoglu, E (通讯作者)，Istanbul Univ Cerrahpasa, Dept Gen Surg, Cerrahpasa Fac Med, Istanbul, Turkey.
EM enginhatipoglu@yahoo.com
RI pekmezci, salih/AAG-4806-2021; DEMIRYAS, SULEYMAN/A-1508-2019; ŞİMŞEK,
   OSMAN/ABA-5297-2020; Saribeyoglu, Kaya/AAX-4030-2020
OI DEMIRYAS, SULEYMAN/0000-0002-0050-9099; ŞİMŞEK,
   OSMAN/0000-0002-9116-3598; Saribeyoglu, Kaya/0000-0002-8838-4656
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NR 19
TC 9
Z9 12
U1 0
U2 5
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD MAR
PY 2020
VL 26
IS 2
BP 235
EP 241
DI 10.14744/tjtes.2020.66805
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA LG5UP
UT WOS:000528165700012
PM 32185769
OA hybrid
DA 2026-07-24
ER

PT J
AU Alhalawani, AMF
   Towler, MR
AF Alhalawani, Adel M. F.
   Towler, Mark R.
TI A review of sternal closure techniques
SO JOURNAL OF BIOMATERIALS APPLICATIONS
LA English
DT Review
DE Sternotomy; sternal fixation; wiring; interlocking; plating;
   post-operative complications
ID MEDIAN STERNOTOMY CLOSURE; TRANSVERSE PLATE FIXATION; CALCIUM-PHOSPHATE
   CEMENTS; VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS; WOUND-INFECTION;
   BONE-CEMENT; HEART-SURGERY; OSTEOPOROTIC STERNUMS; DEFINITIVE CLOSURE
AB Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid sternal fixation is associated with stability and reduced incidence of post-operative complications. This is a comprehensive review of the literature evaluating invivo, invitro, and clinical responses to applying commercial and experimental surgical tools for sternal fixation after median sternotomy. Wiring, interlocking, plate-screw, and cementation techniques have been examined for closure, but none have experienced widespread adoption. Although all techniques have their advantages, serious post-operative complications were associated with the use of wiring and/or plating techniques in high-risk patients. A fraction of studies have analyzed the use of sternal interlocking systems and only a single study analyzed the effect of using kryptonite cement with wires. Plating and interlocking techniques are superior to wiring in terms of stability and reduced rate of post-operative complications; however, further clinical studies and long-term follow-up are required. The ideal sternal closure should ensure stability, reduced rate of post-operative complications, and a short hospitalization period, alongside cost-effectiveness.
C1 [Alhalawani, Adel M. F.; Towler, Mark R.] Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur, Malaysia.
   [Towler, Mark R.] Ryerson Univ, Dept Mech & Ind Engn, Toronto, ON, Canada.
C3 Universiti Malaya; Toronto Metropolitan University
RP Towler, MR (通讯作者)，Fac Engn & Architectural Sci, Dept Mech & Ind Engn, 350 Victoria St, Toronto, ON M5B 2K3, Canada.
EM mtowler@Ryerson.ca
RI ; Alhalawani, Adel/I-5542-2019; Alhalawani, Adel/I-5542-2019
OI Towler, Mark/0009-0008-5140-6322; Alhalawani, Adel/0000-0002-3374-3172;
   Alhalawani, Adel/0009-0004-1563-9736
FU Atlantic Innovation Fund, Canada [197820]
FX The authors thank the Atlantic Innovation Fund, Canada (Grant no.
   197820) for the financial support.
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NR 87
TC 56
Z9 73
U1 0
U2 23
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0885-3282
EI 1530-8022
J9 J BIOMATER APPL
JI J. Biomater. Appl.
PD NOV
PY 2013
VL 28
IS 4
BP 483
EP 497
DI 10.1177/0885328213495426
PG 15
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 241GN
UT WOS:000326154500001
PM 23812580
DA 2026-07-24
ER

PT J
AU Morykwas, MJ
   Argenta, LC
   SheltonBrown, EI
   McGuirt, W
AF Morykwas, MJ
   Argenta, LC
   SheltonBrown, EI
   McGuirt, W
TI Vacuum-assisted closure: A new method for wound control and treatment:
   Animal studies and basic foundation
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT Wound, Ostomy, and Continence Nurses Conference
CY MAY, 1995
CL DENVER, CO
ID SKIN-FLAP SURVIVAL; CHRONIC PRESSURE ULCERS; GROWTH FACTOR-BB;
   MECHANICAL STRETCH; CARDIAC MYOCYTES; PIG; CELLS; ANGIOGENESIS;
   HYPERTROPHY; ELONGATION
AB A series of basic animal studies using a new subatmospheric pressure technique (The V.A.C.) to expedite wound healing are presented. The technique entails placing an open-cell foam into the wound, sealing the site with an adhesive drape, and applying subatmospheric pressure (125 mmHg below ambient) that is transmitted to the wound in a controlled manner. Utilizing a pig model, four studies were undertaken to determine the effect of subatmospheric pressure on laser Doppler-measured blood flow in the wound and adjacent tissue (N = 5), rate of granulation tissue formation (N = 10), clearance of bacteria from infected wounds (N = 5), and measurement of nutrient flow by random-pattern flap survival (N = 5). Blood flow levels increased fourfold when 125 mmHg subatmospheric pressure was applied. Significantly increased rates of granulation tissue formation (p less than or equal to 0.05) occurred with both continuous (63.3% +/- 26.1%) and intermittent (103% +/- 35.3%) application. Tissue bacterial counts significantly decreased (p less than or equal to 0.05) after 4 days of application. Random-pattern flap survival significantly increased (p less than or equal to 0.05) by 21% compared to controls. We determined that the application of controlled subatmospheric pressure creates an environment that promotes wound healing.
RP Morykwas, MJ (通讯作者)，WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT PLAST & RECONSTRUCT SURG, MED CTR BLVD, WINSTON SALEM, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
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NR 51
TC 1654
Z9 2710
U1 2
U2 116
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 1997
VL 38
IS 6
BP 553
EP 562
DI 10.1097/00000637-199706000-00001
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA XE010
UT WOS:A1997XE01000001
PM 9188970
DA 2026-07-24
ER

PT J
AU Chose, C
   Karadimas, T
   Hederick, L
   Griffin, AM
   Jajoo, V
   Cummings, C
   Connolly, J
   Huynh, TH
   Newman, ET
   Raskin, KA
   Ferguson, PC
   Wunder, JS
   Joyce, D
   Binitie, O
   Mhaskar, R
   Lozano-Calderon, SA
   Tsoi, K
   Lazarides, AL
AF Chose, Chloe
   Karadimas, Thomas
   Hederick, Lucy
   Griffin, Anthony M.
   Jajoo, Veena
   Cummings, Caleb
   Connolly, Joseph
   Huynh, Thien Huong
   Newman, Erik T.
   Raskin, Kevin A.
   Ferguson, Peter C.
   Wunder, Jay S.
   Joyce, David
   Binitie, Odion
   Mhaskar, Rahul
   Lozano-Calderon, Santiago A.
   Tsoi, Kim
   Lazarides, Alexander L.
TI Staged Resection with Temporizing VAC and Local Recurrence for Soft
   Tissue Sarcomas: A Multi-Institutional Review
SO CANCERS
LA English
DT Article
DE soft tissue sarcoma; orthopaedic oncology; staged resection
ID SURGICAL MARGIN; EXTREMITY; RECONSTRUCTION; THERAPY; IMPROVE; IMPACT;
   GRADE
AB Background/Objectives: Staged resection with temporizing vacuum-assisted closure (VAC) has been adopted to facilitate margin assessment and local control of soft tissue sarcomas (STS). Accordingly, the objective of this study is to compare rates of local recurrence (LR) among superficial STS patients treated with and without temporizing VAC therapy. Methods: We conducted a multi-institutional retrospective cohort study of superficial STS patients treated at three tertiary care centers. Patients were matched by grade, and descriptive statistics and multivariate binary logistic regression were performed. Results: After matching, 314 superficial STS patients were included in analysis. VAC patients were more likely to present with a history of prior unplanned excision (p = 0.024), with recurrent disease (p = 0.004), harbor a diagnosis of myxofibrosarcoma (p < 0.001), and have positive initial surgical margins (p < 0.001). After multivariate analysis, VAC use remained independently associated with increased LR rates (OR = 4.117; p = 0.003). Conclusions: In this multi-institutional analysis of superficial STS patients, staged resection with temporizing VAC was not associated with improved LR rates. Rather, the VAC cohort represented distinctly higher-risk tumor biology and complex oncologic presentations, in whom the risk of LR may not be fully mitigated by surgical staging alone.
C1 [Chose, Chloe; Karadimas, Thomas; Jajoo, Veena; Cummings, Caleb; Huynh, Thien Huong; Mhaskar, Rahul] Univ S Florida, Morsani Coll Med, Tampa, FL 33602 USA.
   [Hederick, Lucy; Connolly, Joseph; Newman, Erik T.; Raskin, Kevin A.; Lozano-Calderon, Santiago A.] Massachusetts Gen Hosp, Div Orthopaed Oncol, Boston, MA 02114 USA.
   [Griffin, Anthony M.; Ferguson, Peter C.; Wunder, Jay S.; Tsoi, Kim] Mt Sinai Hosp, Div Orthopaed Surg, Toronto, ON M5G 1X5, Canada.
   [Joyce, David; Binitie, Odion; Lazarides, Alexander L.] H Lee Moffitt Canc Ctr & Res Inst, Dept Sarcoma, Tampa, FL 33612 USA.
C3 State University System of Florida; University of South Florida; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; University of Toronto; Sinai Health System Toronto; H Lee
   Moffitt Cancer Center & Research Institute
RP Lazarides, AL (通讯作者)，H Lee Moffitt Canc Ctr & Res Inst, Dept Sarcoma, Tampa, FL 33612 USA.
EM alexander.lazarides@moffitt.org
RI Karadimas, Thomas/KPB-5086-2024; Mhaskar, Rahul/I-4944-2012
FX This research received no external funding.
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN 18
PY 2026
VL 18
IS 12
AR 1984
DI 10.3390/cancers18121984
EA JUN 2026
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KC3NU
UT WOS:001803589500001
PM 42352516
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jeong, SH
   Lee, JK
   Seo, KW
   Min, JS
AF Jeong, Sang-Ho
   Lee, Jin-Kwon
   Seo, Kyung Won
   Min, Jae-Seok
TI Treatment and Prevention of Postoperative Leakage after Gastrectomy for
   Gastric Cancer
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE anastomotic leakage; surgical procedures; operative; gastrectomy;
   stomach neoplasm
ID VACUUM-ASSISTED CLOSURE; ESOPHAGOJEJUNAL ANASTOMOTIC LEAKAGE; ENDOSCOPIC
   SUBMUCOSAL DISSECTION; UPPER GASTROINTESTINAL-TRACT; RISK-FACTORS;
   DISTAL GASTRECTOMY; CONTRAST SWALLOW; DOUBLE-BLIND; MANAGEMENT; SURGERY
AB Anastomotic leakage is one of the common causes of serious morbidity and death after gastrectomy. The use of surgical treatment for leakage decreased due to the development of nonsurgical management. However, if nonsurgical management fails to control the spread of intra-abdominal infection, emergency surgical treatment is required. The authors wished to determine in which cases surgical treatment is needed for postoperative leakage and to identify treatment and prevention strategies. If a patient's vital signs are stable, local abscesses can be cured by conservative treatment after percutaneous drain insertion; if there is no improvement in anastomotic leakage, endoscopic treatment such as clipping, vacuum, and stent placement can be performed. If a patient's vital signs are unstable or patient shows diffuse peritonitis, surgical treatment should be performed. A surgical plan can be established according to leakage location. The duodenal stump may first require conservative treatment. It is recommended that surgical treatment be attempted first for anastomotic leakage of gastrojejunostomy site and gastric stump in remnant stomach. In conclusion, the need for surgical treatment is determined depending on vital signs and presence of diffuse peritonitis. During surgical treatment, a strategic approach is required according to the patient's condition and the anatomical location of leakage.
C1 [Jeong, Sang-Ho; Lee, Jin-Kwon] Gyeongsang Natl Univ, Dept Surg, Sch Med, Chang Won 51471, South Korea.
   [Jeong, Sang-Ho; Lee, Jin-Kwon] Gyoengsang Natl Univ, Changwon Hosp, Chang Won 51471, South Korea.
   [Seo, Kyung Won] Kosin Univ, Dept Surg, Gospel Hosp, Busan 49267, South Korea.
   [Min, Jae-Seok] Dongnam Inst Radiol & Med Sci, Canc Ctr, Dept Surg, Busan 46033, South Korea.
C3 Gyeongsang National University; Korea Institute of Radiological &
   Medical Sciences
RP Min, JS (通讯作者)，Dongnam Inst Radiol & Med Sci, Canc Ctr, Dept Surg, Busan 46033, South Korea.
EM jshgnu@gmail.com; gsbigcap@gmail.com; hahachristi@gmail.com;
   mdoogy@naver.com
RI Min, Jae-Seok/ABG-5529-2022; Lee, Jin-Kwon/L-7826-2015
OI Min, Jae-Seok/0000-0002-5798-4595; Lee, Jin-Kwon/0000-0001-6113-7252
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NR 98
TC 17
Z9 24
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2023
VL 12
IS 12
AR 3880
DI 10.3390/jcm12123880
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K2ID1
UT WOS:001014719000001
PM 37373575
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sporns, PB
   Zimmer, S
   Hanning, U
   Zoubi, T
   Wölfer, J
   Herbort, M
   Schwindt, W
   Niederstadt, T
AF Sporns, Peter Bernhard
   Zimmer, Sebastian
   Hanning, Uta
   Zoubi, Tarek
   Woelfer, Johannes
   Herbort, Mirco
   Schwindt, Wolfram
   Niederstadt, Thomas
TI Acute tonsillar cerebellar herniation in a patient with traumatic dural
   tear and VAC therapy after complex trauma
SO SPINE JOURNAL
LA English
DT Article
DE Trauma; VAC; Intracranial hypotension; Tonsillar herniation; Dural tear;
   Cerebrospinal fluid
AB BACKGROUND CONTEXT: Cases of cerebral hypotension and tonsillar herniation after accidental lumbar cerebrospinal fluid (CSF) drainage or chest tube drainage with intrathoracic CSF leaks have been reported. To the authors' knowledge, this case presents the first report of severe intracranial hypotension because of suction of CSF by a Vacuum-Assisted Closure (VAC) device.
   PURPOSE: The purpose of this study was to report a life-threatening intracranial hypotension in a polytraumatized patient after VAC therapy.
   STUDY DESIGN: This study is a case report.
   METHODS: A 23-year-old woman suffered of a Grade 3 open pelvic fracture after a motor vehicle accident. After a VAC therapy, the patient became nonresponsive. A cranial computer tomography (CCT) showed signs of intracranial hypotension with narrowing of the basal cisterns and sagging of the cerebellar tonsils. The VAC was removed. Further neuroradiological diagnostic showed a tear in the dural sac at the L5-S1 level. The patient consequently underwent neurosurgery. After a dural patch, she was oriented postoperatively and the CCT improved to a normal state.
   RESULTS: Fifteen days after admission, the patient was discharged without neurologic sequelae.
   CONCLUSIONS: Severely injured patients undergoing VAC therapy with secondary neurologic deterioration not because of head injury should be appropriately diagnosed to rule out dural laceration and cranial hypotension. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Sporns, Peter Bernhard; Zimmer, Sebastian; Hanning, Uta; Zoubi, Tarek; Schwindt, Wolfram; Niederstadt, Thomas] Univ Hosp, Dept Clin Radiol, D-48149 Munster, Germany.
   [Woelfer, Johannes] Univ Hosp, Dept Neurosurg, D-48149 Munster, Germany.
   [Herbort, Mirco] Univ Hosp, Dept Trauma Surg, D-48149 Munster, Germany.
C3 University of Munster; University of Munster; University of Munster
RP Sporns, PB (通讯作者)，Univ Hosp, Dept Clin Radiol, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany.
EM peter.sporns@ukmuenster.de
RI Hanning, Uta/ACB-3126-2022
OI Hanning, Uta/0000-0002-7543-8555; Sporns, Peter
   Bernhard/0000-0002-3028-0539
CR Baugnon KL, 2014, NEUROIMAG CLIN N AM, V24, P439, DOI 10.1016/j.nic.2014.03.001
   Fehnel CR, 2014, BMJ CASE REP, V2014
   Kalani MYS, 2013, WORLD NEUROSURG, V79, DOI 10.1016/j.wneu.2011.04.028
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   Mokri B, 2000, Neurosurg Focus, V9, pe6
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   Sugrue PA, 2009, J NEUROSURG, V110, P800, DOI 10.3171/2008.5.17568
NR 12
TC 9
Z9 9
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD JUL 1
PY 2015
VL 15
IS 7
BP E13
EP E16
DI 10.1016/j.spinee.2015.04.025
PG 4
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA CK6BY
UT WOS:000356314000003
PM 25912500
DA 2026-07-24
ER

PT J
AU Nagell, CF
   Holte, K
AF Nagell, Carl Frederik
   Holte, Kathrine
TI Treatment of anastomotic leakage after rectal resection with transrectal
   vacuum-assisted drainage (VAC) - A method for rapid control of pelvic
   sepsis and healing
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE anastomotic leakage; VAC; rectal; healing
ID CLOSURE SYSTEM; WOUND CONTROL; RISK-FACTORS
AB Objectives : Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor functional result is not uncommon. Vacuum-assisted closure (VAC) has been shown to accelerate wound healing by increasing local blood flow, reducing bacterial load and stimulating growth of granulation tissue. In this paper, we describe VAC as a method for treating anastomotic leakage after rectal resection. Methods : Four patients with anastomotic leakage after rectal resections were treated with VAC. Results : Healing time for these patients was median 51 days (43-195). The control group consisted of patients treated conservatively in the previous 5-year period. Ten patients were identified with median healing time 336 days (52-1434).
   Conclusions :VAC treatment may possibly shorten healing time of anastomotic leakages after rectal resection. However, the presented results are preliminary, with only few patients included, and obviously, larger, randomized, clinical trials are needed to confirm these results and establish the indication for VAC treatment in clinical practice. We believe VAC therapy is a promising treatment of anastomotic leakage after rectal resection.
C1 Hvidovre Univ Hosp, Dept Surg Gastroenterol, DK-2650 Hvidovre, Copenhagen, Denmark.
C3 University of Copenhagen
RP Nagell, CF (通讯作者)，Hvidovre Univ Hosp, Dept Surg Gastroenterol, Kettegaards Alle, DK-2650 Hvidovre, Copenhagen, Denmark.
EM rikke.frederik@dadlnet.dk
RI Holte, Kathrine/MCX-4615-2025
OI Holte, Kathrine/0009-0004-4680-8344
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 11
TC 55
Z9 61
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD OCT
PY 2006
VL 21
IS 7
BP 657
EP 660
DI 10.1007/s00384-005-0083-4
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 087FV
UT WOS:000240729200007
PM 16447032
DA 2026-07-24
ER

PT J
AU Creta, M
   Sica, A
   Napolitano, L
   Celentano, G
   La Rocca, R
   Capece, M
   Calogero, A
   Califano, G
   Vanni, L
   Mangiapia, F
   Arcaniolo, D
   Spirito, L
   Fusco, F
   De Sio, M
   Imbimbo, C
   Mirone, V
   Sagnelli, C
   Longo, N
AF Creta, Massimiliano
   Sica, Antonello
   Napolitano, Luigi
   Celentano, Giuseppe
   La Rocca, Roberto
   Capece, Marco
   Calogero, Armando
   Califano, Gianluigi
   Vanni, Luigi
   Mangiapia, Francesco
   Arcaniolo, Davide
   Spirito, Lorenzo
   Fusco, Ferdinando
   De Sio, Marco
   Imbimbo, Ciro
   Mirone, Vincenzo
   Sagnelli, Caterina
   Longo, Nicola
TI Fournier's Gangrene in Patients with Oncohematological Diseases: A
   Systematic Review of Published Cases
SO HEALTHCARE
LA English
DT Review
DE Fournier's gangrene; necrotizing fasciitis; oncohematology
ID ACUTE PROMYELOCYTIC LEUKEMIA; HYPERBARIC-OXYGEN THERAPY; NECROTIZING
   FASCIITIS; PSEUDOMONAS-AERUGINOSA; CASE SERIES; MORTALITY; INFECTION;
   CHILDREN; SCROTUM; PENIS
AB Patients suffering from hematological malignancies are at increased risk of Fournier's gangrene (FG) due to immunosuppression caused by the disease itself or by disease-related treatments. A systematic review of PubMed, ISI Web of Knowledge, and Scopus databases was performed in June 2021. We included full papers that met the following criteria: original research, human studies, and describing clinical presentation, treatment, and outcomes of FG in patients with oncohematological diseases. We identified 35 papers published from 1983 to 2021 involving 44 patients (34 males, 8 females) aged between 4 days and 83 years. The most common malignant hematological disorders were acute myeloid leukemia (n = 21) and acute lymphocytic leukemia (n = 9). In 10 patients FG represented the first presentation of hematological malignancy. Scrotum (n= 27) and perineum (n =11) were the sites most commonly involved. Pseudomonas aeruginosa (n = 21) and Escherichia coli (n = 6) were the most commonly isolated microorganisms. Surgery was performed in 39 patients. Vacuum-assisted closure and hyperbaric oxygen therapy were adopted in 4 and in 3 patients, respectively. Recovery was achieved in 30 patients. FG-related mortality was observed in 11 patients. FG should be carefully considered in patients with oncohematological diseases.
C1 [Creta, Massimiliano; Napolitano, Luigi; Celentano, Giuseppe; La Rocca, Roberto; Capece, Marco; Califano, Gianluigi; Mangiapia, Francesco; Spirito, Lorenzo; Imbimbo, Ciro; Mirone, Vincenzo; Longo, Nicola] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80130 Naples, Italy.
   [Sica, Antonello] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80123 Naples, Italy.
   [Calogero, Armando] Univ Naples Federico II, Dept Adv Biomed Sci, I-80130 Naples, Italy.
   [Vanni, Luigi] Univ Naples Federico II, Dept Publ Hlth, I-80130 Naples, Italy.
   [Arcaniolo, Davide; Fusco, Ferdinando; De Sio, Marco] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Urol Unit, I-81100 Naples, Italy.
   [Sagnelli, Caterina] Univ Campania Luigi Vanvitelli, Dept Mental Hlth & Publ Med, I-80131 Naples, Italy.
C3 University of Naples Federico II; Universita della Campania Vanvitelli;
   University of Naples Federico II; University of Naples Federico II;
   Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Creta, M (通讯作者)，Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80130 Naples, Italy.
EM massimiliano.creta@unina.it; antonello.sica@fastwebnet.it;
   luiginap89@gmail.com; dr.giuseppecelentano@gmail.com;
   roberto.larocca@unina.it; drmarcocapece@gmail.com;
   armando.calogero2@unina.it; gianl.califano2@gmail.com;
   luigi.vanni@libero.it; mangiapippo@libero.it;
   davide.arcaniolo@gmail.com; lorenzospirito@msn.com;
   ferdinandolusco@unicampania.it; marco.desio@unicampania.it;
   ciro.imbimbo@unina.it; mirone@unina.it;
   caterina.sagnelli@unicampania.it; nicola.longo@unina.it
RI De Sio, Marco/AAA-6330-2021; Creta, Massimiliano/K-2971-2016;
   Napolitano, Luigi/GLU-7753-2022; Sagnelli, Caterina/K-9338-2016; SICA,
   ANTONELLO/AAS-4471-2021
OI De Sio, Marco/0000-0003-0820-6030; Creta,
   Massimiliano/0000-0003-2082-3330; Califano,
   Gianluigi/0000-0002-2225-5683; Napolitano, Luigi/0000-0003-2036-0356;
   Sagnelli, Caterina/0000-0002-6413-7810; Arcaniolo,
   Davide/0000-0002-5282-2335; Celentano, Giuseppe/0000-0002-3346-8385;
   Longo, Nicola/0009-0009-3394-0596; Capece, Marco/0000-0002-1951-404X;
   Spirito, Lorenzo/0000-0003-1175-8637
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NR 50
TC 13
Z9 14
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD SEP
PY 2021
VL 9
IS 9
AR 1123
DI 10.3390/healthcare9091123
PG 20
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA UV5CN
UT WOS:000699496400001
PM 34574898
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Weckbach, S
   Lutz, B
   Wölfle-Roos, JV
   Reichel, H
AF Weckbach, S.
   Lutz, B.
   Woelfle-Roos, J. V.
   Reichel, H.
TI Infections of the spine. Therapeutic strategies
SO CHIRURG
LA German
DT Article
DE Spondylitis; Spondylodiscitis; Antibiotics; Operative therapy;
   Nonsurgical therapy
ID VERTEBRAL OSTEOMYELITIS; WOUND-INFECTION; MANAGEMENT; SPONDYLODISCITIS;
   FUSION; INSTRUMENTATION; DIAGNOSIS; ADULTS
AB Spinal infections are relatively rare entities but the incidence is significantly increasing due to the rapidly growing numbers of interventions on the spine. Primary infections of intervertebral discs (spondylodiscitis) and vertebral bodies (spondylitis) are distinguished from secondary postinterventional infections. Treatment relies primarily on either conservative or surgical management. In the absence of indications for surgery, a conservative approach is indicated when the patient is neurologically intact and the bony destruction is minimal. Conservative therapeutic options are based on the microbiological diagnosis and use of antibiotics, immobilization, analgesics and orthotics. Indications for a surgical intervention are the presence of neurological deficits, intraspinal abscesses, extensive osseous destruction and failure of conservative management. Surgical therapy focusses on the decompression of neural structures, debridement and eradication of the focus of infection, pathogen identification, correction of the deformity and restoration of a physiological spinal profile. Following a postoperative infection a timely diagnosis including assessment of the extent of infection is crucial. In the case of a purely superficial infection, antibiotic prophylaxis and close monitoring is indicated. If findings are pronounced surgical revision, debridement together with antibiotic therapy and if necessary vacuum-assisted closure as well as revision ranging from exchange of implants to complete removal of osteosynthetic material are required. Spinal infections are severe conditions frequently with residual long-term sequelae, whether the patients are managed conservatively or surgically.
C1 [Weckbach, S.; Lutz, B.; Woelfle-Roos, J. V.; Reichel, H.] Univ Ulm, RKU, Orthopad Univ Klin Ulm, Oberer Eselsberg 45, D-89081 Ulm, Germany.
C3 Ulm University
RP Weckbach, S (通讯作者)，Univ Ulm, RKU, Orthopad Univ Klin Ulm, Oberer Eselsberg 45, D-89081 Ulm, Germany.
EM Sebastian.Weckbach@rku.de
RI Lutz, Bernd/AAS-8025-2021
OI Lutz, Bernd/0000-0003-2599-5836
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NR 20
TC 3
Z9 5
U1 2
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD OCT
PY 2016
VL 87
IS 10
BP 839
EP 846
DI 10.1007/s00104-016-0247-5
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DY5TF
UT WOS:000385165500005
PM 27484826
DA 2026-07-24
ER

PT J
AU De Martino, C
   Caiazzo, P
   Albano, M
   Calbi, F
   Pastore, M
   Tramutoli, PR
AF De Martino, Ciro
   Caiazzo, Paolo
   Albano, Michele
   Calbi, Francesco
   Pastore, Mauro
   Tramutoli, Pio Rocco
TI Laparostomy with topical negative pressure for treating severe
   peritonitis Preliminary experience with 16 cases and review of the
   literature
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Laparostomy; Peritonitis; Topical negative pressure
ID VACUUM-ASSISTED CLOSURE; LONG-TERM IMPACT; OPEN ABDOMEN; SECONDARY
   PERITONITIS; DAMAGE CONTROL; MANAGEMENT; THERAPY; TRAUMA
AB INTRODUCTION: The aim of this study was to assess the authors' initial experience with laparostomy and intraperitoneal topical negative pressure (TNP) in patients with severe peritonitis. The authors also reviewed the recent literature on the effectiveness and safety of abdominal TNP.
   PATIENTS AND METHODS: Sixteen patients (10 male, 6 female, mean age 55 years), suffering from severe peritonitis, underwent emergency laparotomy and laparostomy with TNP Abdominal sepsis originated from the small intestine (n = 7), large intestine (n = 6), biliary tract (n = 2), and pancreas (n = 1). In 2 patients abdominal wall mesh infection and soft tissue gangrene were observed.
   RESULTS: The mortality rate was 31.2%. The main complications probably related to TNP were enteric fistulae (25%), bleeding (25%), abdominal abscesses (12.5%), bowel ischemia (62%). Delayed primary closure was performed in 8 patients (57.1%) whereas in 6 cases a parietal graft was necessary, and one patient underwent an autologus skin graft.
   CONCLUSIONS: Laparostomy with intraperitoneal TNP is a safe and effective method for managing patients with severe peritonitis. Morbidity can be reduced through individualized application of the laparostomy dressing and pressure gradient. The abdominal wall should be managed in such a way as to make possible delayed primary closure.
C1 [De Martino, Ciro; Caiazzo, Paolo; Albano, Michele; Calbi, Francesco; Pastore, Mauro; Tramutoli, Pio Rocco] San Carlo Reg Hosp Potenza, Emergency Surg Unit, Potenza, Italy.
RP De Martino, C (通讯作者)，Via F Wenner 18, I-84080 Pellezzano, SA, Italy.
EM ciro.de@tiscali.it
OI De Martino, Ciro/0000-0001-6055-7802
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NR 24
TC 1
Z9 1
U1 0
U2 3
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD JUL-AUG
PY 2013
VL 84
IS 4
BP 429
EP 436
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217KI
UT WOS:000324358000012
PM 23917343
DA 2026-07-24
ER

PT J
AU Marinis, A
   Gkiokas, G
   Argyra, E
   Fragulidis, G
   Polymeneas, G
   Voros, D
AF Marinis, A.
   Gkiokas, G.
   Argyra, E.
   Fragulidis, G.
   Polymeneas, G.
   Voros, D.
TI "ENTEROATMOSPHERIC FISTULAE"-GASTROINTESTINAL OPENINGS IN THE OPEN
   ABDOMEN: A REVIEW AND RECENT PROPOSAL OF A SURGICAL TECHNIQUE
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE Enteroatmospheric; fistula; open abdomen; vacuum-assisted therapy;
   vacuum-assisted closure; enterocutaneous; enteric fistula
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; SMALL-BOWEL
   FISTULAS; ENTEROCUTANEOUS FISTULAS; EXPOSED FISTULA; MANAGEMENT; WOUNDS;
   SEPSIS
AB The occurrence of an enteric fistula in the middle of an open abdomen is called an enteroatmospheric fistula, which is the most challenging and feared complication for a surgeon to deal with. It is in fact not a true fistula because it neither has a fistula tract nor is covered by a well-vascularized tissue. The mortality of enteroatmospheric fistulae was as high as 70% in past decades but is currently approximately 40% due to advanced modern intensive care and improved surgical techniques. Management of patients with an open abdomen and an enteroatmospheric fistula is very challenging. Intensive care support of organs and systems is vital in order to manage the severely septic patient and the associated multiple organ failure syndrome. Many of the principles applied to classic enterocutaneous fistulae are used as well. Control of enteric spillage, attempts to seal the fistula, and techniques of peritoneal access for excision of the involved loop are reviewed in this report. Additionally, we describe our recent proposal of a lateral surgical approach via the circumference of the open abdomen in order to avoid the hostile and granulated surface of the abdominal trauma, which is adhered to the intraperitoneal organs.
C1 [Marinis, A.] Tzaneion Gen Hosp, Dept Surg 1, GR-18536 Piraeus, Greece.
   [Gkiokas, G.; Fragulidis, G.; Polymeneas, G.; Voros, D.] Aretaieion Univ Hosp, Dept Surg 2, Athens, Greece.
   [Argyra, E.] Aretaieion Univ Hosp, Dept Anesthesiol 1, Athens, Greece.
RP Marinis, A (通讯作者)，Tzaneion Gen Hosp, Dept Surg 1, 1 Zanni & Afentouli STRs, GR-18536 Piraeus, Greece.
EM drmarinis@gmail.com
RI Gkiokas, Georgios/AAE-6312-2020
OI Fragulidis, Georgios/0000-0001-6011-8674; Marinis,
   Athanasios/0000-0001-6423-6651
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   Vargo D, 2009, AM SURGEON, V75, pS1
   Verhaalen A, 2010, WOUNDS, V22, P212
NR 30
TC 58
Z9 67
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PD JUN
PY 2013
VL 102
IS 2
BP 61
EP 68
DI 10.1177/1457496913482252
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AG7FC
UT WOS:000335582700003
PM 23820678
DA 2026-07-24
ER

PT J
AU Bischoff, G
   Muehling, B
   Orend, K
   Bischoff, M
   Sunder-Plassmann, L
AF Bischoff, G.
   Muehling, B.
   Orend, K.
   Bischoff, M.
   Sunder-Plassmann, L.
TI A New Treatment Concept for Bronchial Stump Insufficiency
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE vacuum therapy; bronchial stump; insufficiency; bronchopulmonary fistula
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND INFECTIONS; DEFINITIVE CLOSURE;
   NEGATIVE-PRESSURE; SEALING TECHNIQUE; TISSUE DEFECTS; THERAPY; SURGERY;
   MEDIASTINITIS; MANAGEMENT
AB Introduction: Bronchial stump insufficiency (BSI) remains one of the most feared complications with an incidence of 0-12% in the literature.
   Patients and Method: The present retrospective study reviewed the medical records of 11 patients with BSI. Patients were divided into two groups, depending on treatment. In group A, 5 patients were treated initially unsuccessfully using other therapeutic procedures such pectoralis flap transposition, omentum majus transposition and fibrin glue applications and subsequently treated successfully with vacuum therapy (VT). In 6 patients (group B), only VT (a combination of bronchial suture, thoracoplasty, latissimus muscle transposition and VT) was performed. VT represents a closed dressing system allowing moist wound treatment in full contact with the wound surface as well as protection against contamination with nosocomial pathogens by means of continuous drainage of wound secretions.
   Results: Of the 11 patients reviewed in this study, closure of the bronchial stump with VT was achieved in 8 patients. Of the 8 patients with successful closure of the bronchial stump, 4 patients were in group A and 4 in group B.
   Conclusion: Based on this preliminary experience, the combination of bronchial suture, thoracoplasty, latissimus muscle transposition and VT appears to be a promising concept for the management of bronchial stump insufficiency.
C1 [Bischoff, G.] Univ Ulm, Dept Thorac & Vasc Surg, D-89075 Ulm, Germany.
   Univ Ulm, Dept Trauma Hand Plast & Reconstruct Surg, D-89075 Ulm, Germany.
C3 Ulm University; Ulm University
RP Bischoff, G (通讯作者)，Univ Ulm, Dept Thorac & Vasc Surg, Steinhovelstr 9, D-89075 Ulm, Germany.
EM gisela.bischoff@uniklinik-ulm.de
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NR 34
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD APR
PY 2010
VL 58
IS 3
BP 169
EP 174
DI 10.1055/s-0029-1240780
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 580BD
UT WOS:000276420900007
PM 20376728
DA 2026-07-24
ER

PT J
AU Castrejón, EBM
   Reina-Bautista, E
   Ventura-Gómez, ST
   Cisneros, AM
   Ramos, JAJ
   Durán, MAS
   Ventura, JA
   Valencia-Ledezma, OE
   Frias-De-León, MG
   Salazar, EG
   Castro-Fuentes, CA
AF Castrejon, Esteban Bladimir Martinez
   Reina-Bautista, Erika
   Ventura-Gomez, Sandra Tania
   Cisneros, Araceli Maldonado
   Ramos, Jessica Alejandra Juarez
   Duran, Miguel Alejandro Sanchez
   Ventura, Jesus Aguilar
   Valencia-Ledezma, Omar Esteban
   Frias-De-Leon, Maria Guadalupe
   Salazar, Eduardo Garcia
   Castro-Fuentes, Carlos Alberto
TI Empyema Necessitatis Caused by Prevotella melaninogenica and
   Dialister pneumosintes Resolved with Vacuum-Assisted Closure
   System: A Case Report
SO MICROORGANISMS
LA English
DT Article
DE empyema necessitatis; Prevotella; Dialister; VAC; case report
ID RESISTANT STAPHYLOCOCCUS-AUREUS; THERAPY
AB Empyema necessitatis is a rare complication of an untreated or inadequately controlled empyema. We present the case of an 11-year-old female adolescent living in precarious conditions, overcrowding, incomplete vaccinations, irregular dental hygiene, and no significant family or personal medical history. The patient started with symptoms one week prior to her hospitalization, presenting a persistent sporadic dry cough, and was later diagnosed with complicated pneumonia, resulting in the placement of an endopleural tube. Vancomycin (40 mg/kg/day) and ceftriaxone (75 mg/kg/day) were administered. However, the clinical evolution was unfavorable, with fever and respiratory distress, so a right jugular catheter was placed. The CT scan showed a loculated collection that occupied the entire right lung parenchyma and pneumothorax at the right upper lobe level. After four days of treatment, the patient still presented purulent drainage with persistent right pleural effusion syndrome. P. melaninogenica and D. pneumosintes were identified from the purulent collection on the upper right lobe, so the antimicrobial treatment was adapted to a glycopeptide, Teicoplanin, at a weight-based dosing of 6 mg/kg/day and Metronidazole at a weight-based dosing of 30 mg/kg/day. In addition, VAC therapy was used for 26 days with favorable resolution.
C1 [Castrejon, Esteban Bladimir Martinez; Ventura-Gomez, Sandra Tania; Cisneros, Araceli Maldonado; Ramos, Jessica Alejandra Juarez; Duran, Miguel Alejandro Sanchez; Ventura, Jesus Aguilar] Hosp Reg Alta Especial Ixtapaluca, Pediat Intens Care Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Reina-Bautista, Erika] Hosp Reg Alta Especial Ixtapaluca, Pediat Infectol Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Valencia-Ledezma, Omar Esteban; Castro-Fuentes, Carlos Alberto] Hosp Reg Alta Especial Ixtapaluca, Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
   [Frias-De-Leon, Maria Guadalupe; Salazar, Eduardo Garcia] Hosp Reg Alta Especial Ixtapaluca, Biomed Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
RP Ventura-Gómez, ST (通讯作者)，Hosp Reg Alta Especial Ixtapaluca, Pediat Intens Care Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.; Castro-Fuentes, CA (通讯作者)，Hosp Reg Alta Especial Ixtapaluca, Res Unit, IMSS BIENESTAR, Alcaldia Alvaro Obregon, Calle Gustavo E Campa 54, Mexico City 01020, Mexico.
EM estebanmartinezcastrejon05@gmail.com; erika.reinab@gmail.com;
   venturagst@gmail.com; aisely_girl@hotmail.com; alehu.ice10@gmail.com;
   dr_miguelsanchez@hotmail.com; jesus.aguilar.v@hotmail.com;
   esteban84valencia@gmail.com; magpefrias@gmail.com;
   eduardogs01@hotmail.com; castrofuenca@gmail.com
RI ; Castro-Fuentes, Carlos Alberto/NFS-7962-2025
OI Frías De León, María Guadalupe/0000-0002-3160-8698; Castro-Fuentes,
   Carlos Alberto/0000-0002-1277-7170; SANCHEZ DURAN, MIGUEL
   ALEJANO/0009-0008-4890-4179; VALENCIA-LEDEZMA, OMAR
   ESTEBAN/0000-0002-7239-7946
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NR 23
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD SEP
PY 2024
VL 12
IS 9
AR 1881
DI 10.3390/microorganisms12091881
PG 8
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA H9J6U
UT WOS:001326528000001
PM 39338554
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lesser, T
AF Lesser, Thomas
TI Residual Pleural Space after Lung Resection
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE lung resection; residual pleural space; thoracoplasty; muscle flap
   transposition; decortication
ID OPEN-WINDOW THORACOSTOMY; VACUUM-ASSISTED CLOSURE; AIR LEAKS;
   POSTPNEUMONECTOMY EMPYEMA; BRONCHOPLEURAL FISTULA; ACCELERATED
   TREATMENT; THORACIC-SURGERY; MANAGEMENT; PNEUMOPERITONEUM; THORACOPLASTY
AB Approximately 10% of patients exhibit a residual pleural space after anatomical lung resection. The most common causes are related to interstitial lung diseases associated with reduced compliance and air leaks. If no complication occurs by the end of the 4th week, an uncomplicated course ( absorption of air) can be expected. In the event of pleural space infection and/or bronchopleural fistula, there is a risk of aspiration, with the development of life-threatening pneumonia. In such cases, surgical treatment is indicated. The choice of surgical procedure is an individual decision, whereby the general condition, coexisting diseases, patient's mobility and motivation, pulmonary function, the lung tissue quality, the underlying disease with its prognosis and local as well as systemic effects of the pleural space infection must be taken into account. For the surgical therapy of the residual pleural space, the following methods are available: pleural drainage, pneumoperitoneum, pleura tent, lung decortication, space filling muscle transposition, thoracoplasty, thoracostomy, or combined procedures. Pleural drainage and decortication require an expandable lung. Postpneumonectomy empyema poses a particular challenge. To avoid a pleural space in cases of high risk conditions, prophylactic measures ( pleural tent, pneumoperitoneum, N. phrenicus blockage) can already be performed during initial intervention.
C1 [Lesser, Thomas] SRH Wald Klinikum Gera, Thorax & Gefasschirurg, Str Friedens 122, D-07548 Gera, Germany.
RP Lesser, T (通讯作者)，SRH Wald Klinikum Gera, Thorax & Gefasschirurg, Str Friedens 122, D-07548 Gera, Germany.
EM thomas.lesser@wkg.srh.de
RI /AAC-4603-2020
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NR 64
TC 3
Z9 6
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD SEP
PY 2019
VL 144
SU 1
BP S31
EP S42
DI 10.1055/a-0896-8748
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IU8RW
UT WOS:000483850200011
PM 31250409
DA 2026-07-24
ER

PT J
AU Dong, YC
   Zhang, YH
   Lin, ZX
   Li, XY
   Guo, Z
   Li, T
   Ma, FX
   Li, J
AF Dong, Yuchen
   Zhang, Yuheng
   Lin, Zhixiao
   Li, Xueyong
   Guo, Zheng
   Li, Tian
   Ma, Fuxin
   Li, Jing
TI Negative pressure mechanical signal increases the phosphorylation of
   eNOS Ser1177 by upregulating HSP90 expression to promote wound
   angiogenesis
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Article
DE Mechanical stretching; Chronic wound; Angiogenesis; Single-cell
   sequencing; eNOS
ID VACUUM-ASSISTED CLOSURE; NITRIC-OXIDE SYNTHASE; THERAPY; PROLIFERATION;
   MEDIASTINITIS; MODALITIES; MANAGEMENT; SURGERY; CELLS; NPWT
AB Background: Chronic wound wound therapy (NPWT) clinic Methods: A mechanical stretching model simulating NPWT was established in vitro. Multiomics approaches (single-cell seque HSP90-related regulatory networks. Typical molecular biological techniques are used to detect the expression of relevant proteins. Mor Results: NPWT-induced mech pathogenesis involves impaired angiogenesis. While negative pressure ally promotes angiogenesis, its biomechanical mechanisms remain unclear. ncing, Ch-IP, Co-IP, and molecular docking) were employed to dissect eover, a rat dorsal wound model was used for the animal experiments. anical stimulation activates the GNAS/CREB1/HSP90 axis, increasing HSP90 transcription via CREB1 nuclea phosphorylation, driving angi of GNAS/CREB1 suppresses HS Conclusion: This study reveals a GNAS-mediated mechanotransduction pathway that activates HSP90-dependent eNOS signaling to accelerate wound angiogenesis, suggesting novel targets for therapeutic intervention. (c) 2025 The Authors. Publishe r translocation. Elevated HSP90 displaces Cav-1 to augment eNOS Ser1177 ogenesis to promote wound healing. Pharmacological or genetic disruption P90 expression and angiogenic capacity. d by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Dong, Yuchen; Li, Xueyong; Li, Tian; Ma, Fuxin; Li, Jing] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.
   [Zhang, Yuheng; Guo, Zheng] Fourth Mil Med Univ, Tangdu Hosp, Dept Orthoped, Xian 710038, Peoples R China.
   [Zhang, Yuheng] Western Theater Air Force Hosp PLA, Dept Orthoped, Chengdu 610011, Peoples R China.
   [Lin, Zhixiao] 923 Hosp Joint Logist Support Force PLA, Dept Burn & Plast Surg, Nanning 530022, Peoples R China.
   [Li, Tian] Tianjin Med Univ, Tianjin Nankai Hosp, Inst Integrat Med Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Tianjin
   Medical University
RP Li, T; Ma, FX; Li, J (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.; Li, T (通讯作者)，Tianjin Med Univ, Tianjin Nankai Hosp, Inst Integrat Med Acute Abdominal Dis, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China.
EM fmmult@foxmail.com; mfx1341@163.com; lijing02@fmmu.edu.cn
RI Li, Tian/ADZ-3422-2022
FU Key Research and Development Projects of Shaanxi Province
   [2022ZDLSF04-03]
FX This work was supported by the Key Research and Development Projects of
   Shaanxi Province (2022ZDLSF04-03) .
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NR 69
TC 2
Z9 2
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD APR
PY 2026
VL 82
BP 1011
EP 1026
DI 10.1016/j.jare.2025.07.041
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FF9OY
UT WOS:001717823100001
PM 40721022
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ren, JN
   Yuan, YJ
   Zhao, YZ
   Gu, GS
   Wang, GF
   Chen, J
   Fan, CG
   Wang, XB
   Li, JS
AF Ren, Jianan
   Yuan, Yujie
   Zhao, Yunzhao
   Gu, Guosheng
   Wang, Gefei
   Chen, Jun
   Fan, Chaogang
   Wang, Xinbo
   Li, Jieshou
TI Open Abdomen Treatment for Septic Patients with Gastrointestinal
   Fistula: From Fistula Control to Definitive Closure
SO AMERICAN SURGEON
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH;
   VASCULAR SURGICAL-PATIENTS; CONTROL OPEN CELIOTOMIES; VACUUM-ASSISTED
   CLOSURE; PLANNED VENTRAL HERNIA; ENTEROCUTANEOUS FISTULA;
   DAMAGE-CONTROL; WALL DEFECTS; CDC DEFINITIONS
AB The use of open abdomen in the management of gastrointestinal fistula complicated with severe intra-abdominal infection is uncommon. This study was designed to evaluate outcomes of our staged approach for the infected open abdomen. Patients who had gastrointestinal fistula and underwent open abdomen treatment were retrospectively reviewed. Various materials such as polypropylene mesh and a modified sandwich package were used to achieve temporary abdominal closure followed by skin grafting when the granulation bed matured. A delayed definitive operation was performed for final abdominal closure without implant of prosthetic mesh. Between 1999 and 2009, 56 (68.3%) of 82 patients survived through this treatment. Among them, 42 patients achieved final abdominal closure. Spontaneous fistula closure occurred in 16 patients with secondary fistula recorded in six patients. Besides, wound complications occurred in 13 patients with two cases for pulmonary infection. Within a 12-month follow-up period after definitive closure, no additional fistula was recorded excluding planned ventral hernia repair. Open abdomen treatment was effective for gastrointestinal fistula complicated by severe intra-abdominal infection. A delayed and deliberate operative strategy aiming at fistula excision and fascial closure, with simultaneous abdominal wall reconstruction, was required for the infected open abdomen.
C1 [Ren, Jianan; Zhao, Yunzhao; Gu, Guosheng; Wang, Gefei; Chen, Jun; Fan, Chaogang; Wang, Xinbo; Li, Jieshou] Nanjing Univ, Sch Med, Jinling Hosp, Dept Surg, Nanjing 210008, Jiangsu, Peoples R China.
   [Yuan, Yujie] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastrointestinal Pancreat Surg, Guangzhou 510275, Guangdong, Peoples R China.
C3 Nanjing University; Sun Yat Sen University
RP Ren, JN (通讯作者)，305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
EM JiananR@gmail.com
RI Yuan, Yujie/O-9873-2018; WANG, XINBO/GLR-8671-2022
OI Yuan, Yujie/0000-0001-5786-4377; WANG, XINBO/0000-0001-8524-9662
FU National Natural Science Foundation of China [30872456]; Key Talent
   Foundation of the "135'' Project from the Government of Jiangsu Province
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 30872456) and the Key Talent Foundation of the
   "135'' Project from the Government of Jiangsu Province.
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NR 34
TC 11
Z9 15
U1 1
U2 17
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD APR
PY 2014
VL 80
IS 4
BP 339
EP 347
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AJ5RL
UT WOS:000337744400014
PM 24887663
DA 2026-07-24
ER

PT J
AU Zuckermann, A
   Barten, MJ
AF Zuckermann, Andreas
   Barten, Markus J.
TI Surgical wound complications after heart transplantation
SO TRANSPLANT INTERNATIONAL
LA English
DT Review
DE heart transplantation; immunosuppression; mammalian target of rapamycin
   inhibitor; surgical wound complication; wound healing event
ID PROLIFERATION SIGNAL INHIBITORS; VACUUM-ASSISTED CLOSURE; BYPASS
   GRAFT-SURGERY; RISK-FACTOR-ANALYSIS; CARDIAC-SURGERY;
   MYCOPHENOLATE-MOFETIL; HEALING COMPLICATIONS; KIDNEY-TRANSPLANTATION;
   LUNG TRANSPLANTATION; STERNAL DEHISCENCE
AB Surgical wound complications are more frequent in patients undergoing heart transplantation than in other heart surgery patients. This is probably attributed to the presence of additional risk factors in these patients, such as immunosuppression, mechanical support through assist devices and generally poor health. Analyses of wound infections in heart transplantation are based on smaller patient population than those for general heart surgery, and the reported incidences vary largely. The identification of specific risk factors in heart transplant recipients to date is mainly based on retrospective case-control studies in small patient cohorts, the results are controversial, and the comparability of data is limited because of the lack of application of consistent definitions. The impact of immunosuppression and especially immunosuppression with mammalian target of rapamycin (mTOR) inhibitors on the development of surgical wound complications has been widely discussed following reports of increased occurrence with sirolimus. However, nonheart-transplant specific risk factors should also be considered to develop risk profiles and treatment algorithms for individual patients. Data on surgical wound complications in general heart surgery patients and in heart transplant recipients are compared, the impact of modern immunosuppression reviewed, and areas for further investigation discussed.
C1 [Zuckermann, Andreas] Med Univ Vienna, Dept Cardiac Surg, Vienna, Austria.
   [Barten, Markus J.] Univ Klin Herzchirurg, Herzzentrum Leipzig, Leipzig, Germany.
C3 Medical University of Vienna; Heart Center Leipzig GMBH
RP Zuckermann, A (通讯作者)，Univ Klin Chirurg, Vienna, Austria.
EM andreas.zuckermann@meduniwien.ac.at
OI Zuckermann, Andreas/0000-0002-8054-8150
FU Novartis; Roche
FX AZ and MJB: research and travel grants from Novartis and Roche.
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NR 67
TC 36
Z9 39
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0934-0874
EI 1432-2277
J9 TRANSPL INT
JI Transpl. Int.
PD JUL
PY 2011
VL 24
IS 7
BP 627
EP 636
DI 10.1111/j.1432-2277.2011.01247.x
PG 10
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 788RI
UT WOS:000292461700005
PM 21418335
DA 2026-07-24
ER

PT J
AU Brown, DL
   Penington, AJ
AF Brown, David L.
   Penington, Anthony J.
TI Murine skin flap survival may not be affected by underlying fat
   viability
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE surgical flaps; necrosis; wounds and injuries; adipose tissue
ID CLOSED DEGLOVING INJURIES; VACUUM-ASSISTED CLOSURE; AVULSION INJURY;
   ARTERIES; VEINS; PATENCY; EXTENT; MODEL; RAT
AB One problem in the treatment of degloving injuries is the accurate prediction of the survivabitity of the avulsed tissue. Initial evaluation frequently underestimates the degree of eventual flap toss, and in many cases, there is a progressive necrosis that continues over the ensuing days. The pathophysiology of this phenomenon is unclear. We undertook this study to test the theory that underlying devascularised fat contributes to overlying skin necrosis.
   A dorsal random skin flap model was used in the rat. Sixty-six rats were divided into three groups: flaps with viable fat and silicone sheeting underneath, flaps with devascularised fat and silicone sheeting underneath and control flaps with only silicone sheeting underneath. Flap necrosis (% area SEM) was evaluated at one week, and found to be 27.1 +/- 4% in the live fat group, 33.2 +/- 4% in the dead fat group and 33.6 +/- 5% in the control group. One-way analysis of variance showed no statistically significant difference between the three groups at a power of 80%.
   In this study, we have shown that neither tive nor dead fat has a significant influence on the survival of an overlying random skin flap in the rat. (c) 2006 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Bernard OBrien Inst, Fitzroy, Vic 3065, Australia.
   St Vincents Hosp, Dept Surg, Melbourne, Vic, Australia.
   Univ Michigan, Ann Arbor, MI 48109 USA.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St
   Vincents Hospital Sydney; University of Michigan System; University of
   Michigan
RP Penington, AJ (通讯作者)，Bernard OBrien Inst, 42 Fitzroy St, Fitzroy, Vic 3065, Australia.
EM a.penington@unimelb.edu.au
RI Brown, David/KIL-0589-2024
OI Brown, David/0000-0002-5889-9886
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NR 23
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2007
VL 60
IS 3
BP 294
EP 299
DI 10.1016/j.bjps.2005.10.028
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 144PC
UT WOS:000244807400013
PM 17293288
DA 2026-07-24
ER

PT J
AU Shiraishi, Y
   Omasa, M
   Yamashita, S
   Hyung-eun, Y
   Tanahashi, M
   Fukami, T
   Tokyooka, S
   Ode, Y
   Okamoto, T
   Shiraishi, T
   Shintani, Y
   Hida, Y
   Maeda, S
   Matsumoto, I
   Sakairi, Y
   Fukui, M
   Okuda, K
   Tsuchida, M
   Iyoda, A
   Saji, H
   Yoshino, I
AF Shiraishi, Yuji
   Omasa, Mitsugu
   Yamashita, Shinichi
   Hyung-eun, Yoon
   Tanahashi, Masayuki
   Fukami, Takeshi
   Tokyooka, Shinichi
   Ode, Yasuhisa
   Okamoto, Tatsuro
   Shiraishi, Takashi
   Shintani, Yasushi
   Hida, Yasuhiro
   Maeda, Sumiko
   Matsumoto, Isao
   Sakairi, Yuichi
   Fukui, Mariko
   Okuda, Katsuhiro
   Tsuchida, Masanori
   Iyoda, Akira
   Saji, Hisashi
   Yoshino, Ichiro
TI Guidelines for the treatment of empyema (The Japanese Association for
   Chest Surgery)
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE Empyema; Surgery; Decortication; Open window thoracostomy
ID OPEN-WINDOW THORACOSTOMY; VACUUM-ASSISTED CLOSURE; OMENTAL PEDICLE FLAP;
   ANTERIOR MUSCLE FLAP; PLEURAL EMPYEMA; POSTPNEUMONECTOMY EMPYEMA;
   PARAPNEUMONIC EFFUSIONS; SURGICAL DECORTICATION; THORACIC-SURGERY;
   INTRAPLEURAL STREPTOKINASE
AB This article translates the guidelines for the treatment of empyema established by the Japanese Association of Chest Surgery in 2023 from Japanese to English. These guidelines were developed by the Working Group on Guidelines for the Treatment of Empyema of our society, involving the establishment of clinical questions, conducting systematic reviews in accordance with the MINDS (Medical Information Distribution Service) Manual for Guideline Development 2020 version 3.0 and the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) system, and determining the levels of recommendations. Furthermore, external evaluators provided assessments. Subsequently, the guidelines were finalized after receiving public comments from the members of the society. Even in the current era of advanced antibiotic therapy, empyema remains difficult to treat. However, the specific guideline for the treatment of empyema lacks in our country. Each institution is conducting clinical practices in its own way. Therefore, aiming to standardize the treatment of empyema, we have developed a practice guideline of empyema treatment. The pathophysiology of empyema is diverse, so empyema is classified into acute, chronic, and postoperative empyema. The recommended surgical treatment for each type of empyema is described, being categorized by the strength of recommendation, strength of evidence, and consensus rate.
C1 [Shiraishi, Yuji] Fukujuji Hosp, Sect Chest Surg, Japan Anti TB Assoc, Tokyo, Japan.
   [Omasa, Mitsugu] Kobe City Nishi Kobe Med Ctr, Dept Thorac Surg, Kobe, Japan.
   [Yamashita, Shinichi] Fukuoka Univ, Dept Gen Thorac Breast & Pediat Surg, Chikushi Hosp, Fukuoka, Fukuoka, Japan.
   [Hyung-eun, Yoon] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Gen Thorac Surg, Osaka, Japan.
   [Tanahashi, Masayuki] Seirei Mikatahara Gen Hosp, Resp Dis Ctr, Div Thorac Surg, Hamamatsu, Japan.
   [Fukami, Takeshi] Natl Hosp Org Tokyo Natl Hosp, Dept Pathol, Tokyo 2048585, Japan.
   [Tokyooka, Shinichi] Okayama Univ Hosp, Dept Thorac Surg, Okayama, Japan.
   [Ode, Yasuhisa] Shizuoka Canc Ctr, Div Thorac Surg, Shizuoka, Japan.
   [Okamoto, Tatsuro] Natl Hosp Org Kyushu Canc Ctr, Dept Thorac Oncol, Fukuoka, Japan.
   [Shiraishi, Takashi] Fukuoka Univ, Sch Med, Dept Gen Thorac Surg Breast & Pediat Surg, Fukuoka, Japan.
   [Shintani, Yasushi] Osaka Univ, Dept Gen Thorac Surg, Grad Sch Med, Osaka, Japan.
   [Hida, Yasuhiro] Fujita Hlth Univ, Sch Med, Dept Adv Robot & Endoscop Surg, Toyoake, Japan.
   [Maeda, Sumiko] Dokkyo Med Univ, Dept Gen Thorac Surg, Tochigi, Japan.
   [Matsumoto, Isao] Kanazawa Univ, Dept Thorac Surg, Kanazawa, Japan.
   [Sakairi, Yuichi; Yoshino, Ichiro] Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chiba, Japan.
   [Fukui, Mariko] Juntendo Univ, Sch Med, Tokyo, Japan.
   [Okuda, Katsuhiro] Nagoya City Univ, Grad Sch Med Sci, Dept Thorac, Nagoya, Japan.
   [Okuda, Katsuhiro] Nagoya City Univ, Dept Pediat Surg, Grad Sch Med Sci, Nagoya, Japan.
   [Tsuchida, Masanori] Niigata Univ, Grad Sch Med & Dent Sci, Div Thorac & Cardiovasc Surg, Niigata, Japan.
   [Iyoda, Akira] Toho Univ, Dept Surg, Div Chest Surg, Tokyo, Japan.
   [Saji, Hisashi] St Marianna Univ, Dept Thorac Surg, Sch Med, Kawasaki, Japan.
   [Saji, Hisashi] Japanese Assoc Chest Surg, Chief Comm Guideline Assessment, Kyoto, Japan.
   [Yoshino, Ichiro] Int Univ Hlth & Welf Narita Hosp, Narita, Japan.
   [Yoshino, Ichiro] Japanese Assoc Chest Surg, Kyoto, Japan.
C3 Fukujuji Hospital; Kobe City Medical Center General Hospital; Fukuoka
   University; Okayama University; Shizuoka Cancer Center; Kyushu Cancer
   Center; Fukuoka University; University of Osaka; Fujita Health
   University; Dokkyo Medical University; Kanazawa University; Chiba
   University; Juntendo University; Nagoya City University; Nagoya City
   University; Niigata University; Toho University; St Marianna University
RP Iyoda, A (通讯作者)，Toho Univ, Dept Surg, Div Chest Surg, Tokyo, Japan.; Saji, H (通讯作者)，St Marianna Univ, Dept Thorac Surg, Sch Med, Kawasaki, Japan.; Saji, H (通讯作者)，Japanese Assoc Chest Surg, Chief Comm Guideline Assessment, Kyoto, Japan.
EM aiyoda@med.toho-u.ac.jp; hisashisaji@gmail.com
RI Hida, Yasuhiro/A-7761-2012; Ichiro, Yoshino/HCH-1137-2022
OI Matsumoto, Isao/0000-0002-7995-9294
FU Japanese Association of Chest Surgery
FX This guideline was created with financial support from the Japanese
   Association of Chest Surgery. The independence of the guideline working
   group and the guideline review committee has been maintained through the
   entire process of developing this guideline.
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   Wotton R, 2021, INTERACT CARDIOV TH, V32, P928, DOI 10.1093/icvts/ivab009
   Zaheer S, 2006, ANN THORAC SURG, V82, P279, DOI 10.1016/j.athoracsur.2006.01.052
   Zahid I, 2011, INTERACT CARDIOV TH, V12, P818, DOI 10.1510/icvts.2010.254789
NR 93
TC 4
Z9 5
U1 1
U2 3
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD MAY
PY 2025
VL 73
IS 5
BP 312
EP 327
DI 10.1007/s11748-025-02119-0
EA FEB 2025
PG 16
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 1HT5B
UT WOS:001425255000001
PM 39969668
DA 2026-07-24
ER

PT J
AU Sánchez-De-Toca, SE
   Moreno, FM
   Sánchez, PU
   Jiménez, FM
   Massaoui, YA
   García, LC
   Betrán, PB
   Marsellá, AJL
   Ledesma, MM
   Tabanera, AV
   Alonso, MD
   Calvo, AG
AF Sanchez-De-Toca, Sofia E.
   Moreno, Fernando Mendoza
   Sanchez, Patricia Urbon
   Jimenez, Felix Manes
   Massaoui, Yousef Allaoua
   Garcia, Lucas Casalduero
   Betran, Pablo Barat
   Lopez Marsella, Alejandra Julia
   Ledesma, Maria Mejias
   Tabanera, Alberto Vilar
   Alonso, Manuel Diez
   Calvo, Alberto Gutierrez
TI Curative surgery enabled by radiotherapy in rectal cancer: A case report
SO ONCOLOGY LETTERS
LA English
DT Article
DE rectal cancer; radiotherapy; 3D reconstruction; pelvic exenteration;
   perineal reconstruction
AB Neoadjuvant chemo-radiotherapy is the standard of care for patients with locally advanced rectal cancer. However, certain patients are ineligible for chemotherapy due to clinical contraindications such as active infections. Although neoadjuvant therapy remains the preferred approach, guidelines are limited for patients who cannot receive combined treatment. The present report describes a case in which radiotherapy alone, initiated with palliative intent, enabled complete surgical resection. A 46-year-old male patient presented with fever and proctalgia. Imaging revealed a large rectal mass associated with an ischiorectal abscess. Biopsy confirmed T4bN1 rectal adenocarcinoma. Chemotherapy was contraindicated due to ongoing infection; therefore, a diverting colostomy was performed. Short-course radiotherapy led to marked tumor regression. Subsequent pelvic exenteration achieved complete tumor removal. Postoperative wound dehiscence was managed successfully with vacuum-assisted closure therapy. No recurrence was observed on follow-up. The current case illustrates that radiotherapy alone may serve as a bridge to curative surgery in patients unfit for chemo-radiotherapy. The use of 3D reconstruction markedly improved preoperative planning and facilitated precise surgical resection. Additionally, perineal closure with Vicryl mesh and omental interposition minimized postoperative complications. In conclusion, in selected patients with contraindications to total neoadjuvant therapy, radiotherapy alone may be a feasible alternative to enable radical resection. Advanced surgical planning with 3D modeling can enhance outcomes in complex pelvic surgery.
C1 [Sanchez-De-Toca, Sofia E.; Moreno, Fernando Mendoza; Sanchez, Patricia Urbon; Jimenez, Felix Manes; Massaoui, Yousef Allaoua; Garcia, Lucas Casalduero; Betran, Pablo Barat; Lopez Marsella, Alejandra Julia; Ledesma, Maria Mejias; Tabanera, Alberto Vilar; Alonso, Manuel Diez; Calvo, Alberto Gutierrez] Principe Asturias Teaching Hosp, Dept Gen & Digest Surg, Carretera Alcala Meco 1, Madrid 28805, Spain.
RP Sánchez-De-Toca, SE (通讯作者)，Principe Asturias Teaching Hosp, Dept Gen & Digest Surg, Carretera Alcala Meco 1, Madrid 28805, Spain.
EM sofia.sanchezdetoca@hotmail.com
CR Ansari N, 2017, ANN SURG, V265, P882, DOI 10.1097/SLA.0000000000001987
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NR 20
TC 0
Z9 0
U1 1
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD FEB
PY 2026
VL 31
IS 2
AR 92
DI 10.3892/ol.2025.15445
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AX1NN
UT WOS:001658863000001
PM 41522807
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Parrett, BM
   Pomahac, B
   Demling, RH
   Orgill, DP
AF Parrett, Brian M.
   Pomahac, Bohdan
   Demling, Robert H.
   Orgill, Dennis P.
TI Fourth-degree burns to the lower extremity with exposed tendon and bone:
   A ten-year experience
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT 37th Annual Meeting of the American-Burn-Association
CY MAY 10-13, 2005
CL Chicago, IL
SP Amer Burn Assoc
ID VACUUM-ASSISTED CLOSURE; BELOW-KNEE; AMPUTATION LEVEL; FREE FLAPS;
   AMPUTEES; MANAGEMENT; WOUNDS; REHABILITATION; RECONSTRUCTION; EXCISION
AB Fourth-degree extremity burns involve muscle, tendon, and bone, often leading to amputation or significant functional impairment. We report our 10-year experience (1995-2004) at an urban burn center with fourth-degree burns to the lower extremity to characterize treatments and outcomes. Twenty-one patients (40 limbs), mean age of 45 years, were treated for fourth-degree lower-extremity burns with the average extremity burn size of 24% TBSA (range, 2-36%) and a mean fourth-degree burn size of 9% TBSA (range, 2-18%). A mean of eight operations were required for limb salvage. Six free-tissue transfers, 2 fillet flaps, 14 local flaps, and multiple skin grafts were performed. Five patients underwent tibial burring for granulation tissue stimulation, and the subatmospheric pressure device was used in eight patients. Seven limb amputations (18%) were required in four patients, and 76% of patients were ambulatory on follow-up. The mean hospital stay was 76 days with high rates of cellulitis, deep vein thrombosis, and bacteremia. Patients treated with flap closure had a significant decrease in the number of operations required for limb salvage. Fourth-degree lower-extremity burns require multistage reconstructive procedures using multiple levels of the reconstructive ladder but limb salvage is possible in a majority of cases.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, Boston, MA 02215 USA.
   Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Trauma Burns & Crit Care, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02215 USA.
RI Orgill, Dennis/H-7596-2019; Pomahac, Bohdan/AAH-1792-2019
OI Orgill, Dennis/0000-0002-8279-7310; Pomahac, Bohdan/0000-0003-3703-8240
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NR 36
TC 31
Z9 40
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2006
VL 27
IS 1
BP 34
EP 39
DI 10.1097/01.bcr.0000192265.20514.c5
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 044UJ
UT WOS:000237697600006
PM 16566535
DA 2026-07-24
ER

PT J
AU Enderes, J
   Pillny, C
   Standop, J
   Manekeller, S
   Kalff, JC
   Glowka, TR
AF Enderes, Jana
   Pillny, Christiane
   Standop, Jens
   Manekeller, Steffen
   Kalff, Joerg C.
   Glowka, Tim R.
TI Operative Re-Intervention following Pancreatoduodenectomy: What Has
   Changed over the Last Decades
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE operative reintervention; redo surgery; reoperation;
   pancreatoduodenectomy; whipple; pancreatic fistula
ID INTERNATIONAL STUDY-GROUP; PANCREATIC FISTULA; RISK SCORE; SURGICAL
   COMPLICATIONS; RECONSTRUCTION; DEFINITION; MANAGEMENT; OUTCOMES;
   PANCREATOGASTROSTOMY; REOPERATION
AB Background: To investigate changes over the last decades in the management of postoperative complications following pancreatoduodenectomy (PD) with special emphasis on reoperations, their indications, and outcomes. Methods: 409 patients who underwent PD between 2008 and 2021 were retrospectively analyzed with respect to their need for reoperations (reoperation, n = 81, 19.8% vs. no reoperation, n = 328, 80.2%). The cohort was then compared to a second cohort comprising patients who underwent PD between 1989 and 2007 (n = 285). Results: 81 patients (19.8%) underwent reoperation. The main cause of reoperation was the dehiscence of pancreatogastrostomy (22.2%). Reoperation was associated with a longer duration of the index operation, more blood loss, and more erythrocyte concentrates being transfused. Patients who underwent reoperation showed more postoperative complications and a higher mortality rate (25% vs. 2%, p < 0.001). Compared to the earlier cohort, the observed increase in reoperations did not lead to increased mortality (5% vs. 6%, p = 353). Conclusions: The main cause for reoperation has changed over the last decades and was the dehiscence of pancreatogastrostomy. Associated with a leakage of pancreatic fluid and clinically relevant PF, it remains the most devastating complication following PD. Strategies for prevention and treatment, e.g., by endoscopic vacuum-assisted-closure therapy are of utmost importance.
C1 [Enderes, Jana; Pillny, Christiane; Manekeller, Steffen; Kalff, Joerg C.; Glowka, Tim R.] Univ Hosp Bonn, Dept Surg, D-53127 Bonn, Germany.
   [Standop, Jens] DRK Hosp Neuwied, Dept Surg, D-56564 Neuwied, Germany.
C3 University of Bonn
RP Glowka, TR (通讯作者)，Univ Hosp Bonn, Dept Surg, D-53127 Bonn, Germany.
EM tim.glowka@ukbonn.de
RI Kalff, Joerg/U-8580-2017; Glowka, Tim R/AAW-6804-2021
OI Manekeller, Steffen/0000-0002-6159-4506; Glowka, Tim
   R/0000-0001-6996-9766
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NR 36
TC 4
Z9 5
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2022
VL 11
IS 24
AR 7512
DI 10.3390/jcm11247512
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7E4RS
UT WOS:000901157900001
PM 36556127
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Xiao, Y
   Ahadian, S
   Radisic, M
AF Xiao, Yun
   Ahadian, Samad
   Radisic, Milica
TI Biochemical and Biophysical Cues in Matrix Design for Chronic and
   Diabetic Wound Treatment
SO TISSUE ENGINEERING PART B-REVIEWS
LA English
DT Review
DE wound healing; dressing; diabetic; matrix; biomaterial
ID NITRIC-OXIDE-SYNTHASE; VACUUM-ASSISTED CLOSURE; EPIDERMAL-GROWTH-FACTOR;
   NORMAL HUMAN KERATINOCYTES; CRITICAL LIMB ISCHEMIA; GENE-THERAPY;
   IN-VITRO; ELECTRICAL-STIMULATION; EXTRACELLULAR-MATRIX; SKIN
   REGENERATION
AB Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.
C1 [Xiao, Yun; Radisic, Milica] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada.
   [Xiao, Yun; Ahadian, Samad; Radisic, Milica] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto
RP Radisic, M (通讯作者)，Univ Toronto, Inst Biomat & Biomed Engn, Dept Chem Engn & Appl Chem, 164 Coll St,Room 407, Toronto, ON M5S 3G9, Canada.
EM m.radisic@utoronto.ca
RI ; Xiao, Yun/N-9949-2015
OI Radisic, Milica/0000-0003-1249-4135; Xiao, Yun/0000-0003-1779-7741
FU National Sciences and Engineering Research Council of Canada (NSERC)
   Steacie Fellowship; Canadian Institutes of Health Research (CIHR)
   Operating Grant [MOP-126027]; Heart and Stroke Foundation GIA;
   NSERC-CIHR Collaborative Health Research Grant; NSERC Discovery Grant
FX Our work is supported by the National Sciences and Engineering Research
   Council of Canada (NSERC) Steacie Fellowship to M.R., the Canadian
   Institutes of Health Research (CIHR) Operating Grant (MOP-126027), the
   Heart and Stroke Foundation GIA, NSERC-CIHR Collaborative Health
   Research Grant, and NSERC Discovery Grant.
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NR 243
TC 35
Z9 41
U1 1
U2 79
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3368
EI 1937-3376
J9 TISSUE ENG PART B-RE
JI Tissue Eng. Part B-Rev.
PD FEB
PY 2017
VL 23
IS 1
BP 9
EP 26
DI 10.1089/ten.teb.2016.0200
PG 18
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering;
   Materials Science
GA EL3CN
UT WOS:000394497300002
PM 27405960
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Falagas, ME
   Tansarli, GS
   Kapaskelis, A
   Vardakas, KZ
AF Falagas, Matthew E.
   Tansarli, Giannoula S.
   Kapaskelis, Anastasios
   Vardakas, Konstantinos Z.
TI Impact of Vacuum-Assisted Closure (VAC) Therapy on Clinical Outcomes of
   Patients with Sternal Wound Infections: A Meta-Analysis of
   Non-Randomized Studies
SO PLOS ONE
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; LONG-TERM SURVIVAL; SUCTION DRAINAGE;
   CARDIAC-SURGERY; MANAGEMENT; MEDIASTINITIS; MORTALITY; TRIAL; COST
AB Objective: To examine the impact of VAC therapy on mortality of patients with sternal wound infections after cardiothoracic surgery.
   Summary Background Data: Controversial results regarding mortality of patients with sternal wound infections were published.
   Methods: We performed a systematic search in PubMed and Scopus. Mortality was the primary outcome of the meta-analysis. Recurrences, complications and length of stay were secondary outcomes.
   Results: Twenty-two retrospective studies including 2467 patients were eligible for inclusion. Patients treated with VAC had significantly lower mortality compared to those treated without VAC [2233 patients, RR = 0.40, (95% CI 0.28, 0.57)]. This finding was consistent regardless of the study design, the exclusion of studies with positive findings, the criteria for establishment of the compared groups, the time of mortality assessment or the type of infections under study, provided that adequate data was available. VAC therapy was associated with fewer recurrences (RR = 0.34, 95% CI: 0.19-0.59). The meta-analysis did not show any difference in the length of stay (RR = -2.25, 95% CI: -7.52-3.02).
   Conclusions: VAC therapy was associated with lower mortality than other surgical techniques in retrospective cohorts of patients with DSWIs following cardiothoracic surgery.
C1 [Falagas, Matthew E.; Tansarli, Giannoula S.; Kapaskelis, Anastasios; Vardakas, Konstantinos Z.] Alfa Inst Biomed Sci, Athens, Greece.
   [Falagas, Matthew E.; Kapaskelis, Anastasios; Vardakas, Konstantinos Z.] Mitera Hosp, Hygeia Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Falagas, Matthew E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, Athens, Greece.
EM m.falagas@aibs.gr
RI /M-5253-2019
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   Biefer HRC, 2012, EUR J CARDIO-THORAC, V42, P306, DOI 10.1093/ejcts/ezr326
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   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 41
TC 29
Z9 33
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 31
PY 2013
VL 8
IS 5
AR e64741
DI 10.1371/journal.pone.0064741
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 156DC
UT WOS:000319799900092
PM 23741379
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Brölmann, FE
   Ubbink, DT
   Nelson, EA
   Munte, K
   van der Horst, CMAM
   Vermeulen, H
AF Brolmann, F. E.
   Ubbink, D. T.
   Nelson, E. A.
   Munte, K.
   van der Horst, C. M. A. M.
   Vermeulen, H.
TI Evidence-based decisions for local and systemic wound care
SO BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; TOPICAL AGENTS; DRESSINGS; INFECTIONS; QUALITY;
   THERAPY
AB Background: Decisions on local and systemic wound treatment vary among surgeons and are frequently based on expert opinion. The aim of this meta-review was to compile best available evidence from systematic reviews in order to formulate conclusions to support evidence-based decisions in clinical practice. Methods: All Cochrane systematic reviews (CSRs), published by the Cochrane Wounds and Peripheral Vascular Diseases Groups, and that investigated therapeutic and preventive interventions, were searched in the Cochrane Database up to June 2011. Two investigators independently categorized each intervention into five levels of evidence of effect, based on size and homogeneity, and the effect size of the outcomes. Results: After screening 149 CSRs, 44 relevant reviews were included. These contained 109 evidence-based conclusions: 30 on venous ulcers, 30 on acute wounds, 15 on pressure ulcers, 14 on diabetic ulcers, 12 on arterial ulcers and eight on miscellaneous chronic wounds. Strong conclusions could be drawn regarding the effectiveness of: therapeutic ultrasonography, mattresses, cleansing methods, closure of surgical wounds, honey, antibiotic prophylaxis, compression, lidocaineprilocaine cream, skin grafting, antiseptics, pentoxifylline, debridement, hyperbaric oxygen therapy, granulocyte colony-stimulating factors, prostanoids and spinal cord stimulation. Conclusion: For some wound care interventions, robust evidence exists upon which clinical decisions should be based. Copyright (c) 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
C1 [Brolmann, F. E.; Ubbink, D. T.; Vermeulen, H.] Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, NL-1105 AZ Amsterdam, Netherlands.
   [Ubbink, D. T.] Univ Amsterdam, Acad Med Ctr, Dept Gen Surg, NL-1105 AZ Amsterdam, Netherlands.
   [van der Horst, C. M. A. M.] Univ Amsterdam, Acad Med Ctr, Dept Plast Reconstruct & Hand Surg, NL-1105 AZ Amsterdam, Netherlands.
   [Vermeulen, H.] Amsterdam Sch Hlth Profess, Amsterdam, Netherlands.
   [Munte, K.] Erasmus MC, Dept Dermatol, Rotterdam, Netherlands.
   [Nelson, E. A.] Univ Leeds, Sch Healthcare, Leeds, W Yorkshire, England.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam; Erasmus University
   Rotterdam; Erasmus MC; University of Leeds
RP Ubbink, DT (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM d.ubbink@amc.nl
RI Ubbink, Dirk/AAF-1266-2021; Vermeulen, Hester/P-5739-2016; Nelson,
   Andrea/K-2733-2012
OI Ubbink, Dirk/0000-0001-9398-8879; van der Horst,
   chantal/0000-0002-4937-3786; Vermeulen, Hester/0000-0002-0743-2979;
   Nelson, Andrea/0000-0001-6741-3078
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NR 65
TC 61
Z9 74
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2012
VL 99
IS 9
BP 1172
EP 1183
DI 10.1002/bjs.8810
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 982UO
UT WOS:000307071100002
PM 22777856
OA Bronze
DA 2026-07-24
ER

PT J
AU Imren, Y
   Selek, H
   Zor, H
   Bayram, H
   Ereren, E
   Tasoglu, I
   Sariguney, Y
AF Imren, Yildirim
   Selek, Hakan
   Zor, Hakan
   Bayram, Huseyin
   Ereren, Emrah
   Tasoglu, Irfan
   Sariguney, Yakup
TI The management of complicated sternal dehiscence following open heart
   surgery
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND INFECTIONS; FIXATION; PLATE;
   MEDIASTINITIS
AB Background. Wound infection after median sternotomy for cardiac or thoracic surgery is a serious complication, and there is a lack of agreement regarding the best treatment method. We present our results in patients with mediastinitis treated with longitudinally affixed titanium plates on sternal halves.
   Methods. The technique was composite closure using titanium fixation plates to buttress the sternum in combination with circumferential stainless steel wires. The series included 21 patients who developed sternal non-union resulting from mediastinitis. Mobilization of muscular flaps was performed in 8 cases. This technique also consists of sternal and soft tissue debridement and wound closure over mediastinal tubes with continuous irrigation and drainage. Antibiotherapy based on culture and sensitivity data continued for 4 to 7 weeks.
   Results. Twenty patients achieved complete wound healing without further operative intervention or major complication. Nineteen patients treated with this technique survived. One patient died from sepsis after developing residual focus of chondritis and undergoing wide resection of cartilage, and 1 patient died from complications of severe stroke.
   Conclusion. We had good success using aggressive early debridement, closure of the sternal halves with titanium plates, mobilization of muscular flaps, high-volume mediastinal irrigation, and intravenous antibiotics. This approach was a successful salvage technique for revision cases in achieving sternal stability and union when standard methods of closure failed or were unlikely to succeed.
C1 Gazi Univ, Fac Med, Dept Cardiovasc Surg, Gazi Hosp, TR-06500 Ankara, Turkey.
   Gazi Hosp, Dept Orthoped & Traumatol, Ankara, Turkey.
   Gazi Hosp, Dept Plast & Reconstruct Surg, Ankara, Turkey.
C3 Gazi Medical Center; Gazi University; Gazi Medical Center; Gazi
   University; Gazi Medical Center; Gazi University
RP Imren, Y (通讯作者)，Gazi Univ, Fac Med, Dept Cardiovasc Surg, Gazi Hosp, TR-06500 Ankara, Turkey.
EM yimren@gazi.edu.tr
RI Taşoğlu, İrfan/T-4135-2019; Ereren, Emrah/IZP-6743-2023; Bayram,
   Hüseyin/CAI-2638-2022
OI Taşoğlu, İrfan/0000-0001-7714-0296; Ereren, Emrah/0000-0003-1980-1302; 
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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   Smoot EC, 1998, ANN PLAS SURG, V41, P464, DOI 10.1097/00000637-199811000-00002
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
   Upton A, 2005, ANZ J SURG, V75, P198, DOI 10.1111/j.1445-2197.2005.03371.x
NR 24
TC 8
Z9 9
U1 0
U2 3
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD DEC
PY 2006
VL 9
IS 6
BP E871
EP E875
DI 10.1532/HSF98.20061109
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 122DZ
UT WOS:000243207200019
PM 17060043
OA gold
DA 2026-07-24
ER

PT J
AU Morykwas, MJ
   Kennedy, A
   Argenta, JP
   Argenta, LC
AF Morykwas, MJ
   Kennedy, A
   Argenta, JP
   Argenta, LC
TI Use of subatmospheric pressure to prevent doxorubicin extravasation
   ulcers in a swine model
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE doxorubicin; extravasation; vacuum; swine model; wound healing
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; SKIN ULCERS; ADRIAMYCIN;
   NECROSIS; INJURIES; CELLS; DMSO; RAT; PIG
AB Application of subatmospheric pressure to sites injected with doxorubicin prevented ulcer formation in treated sites (0 ulcers/16 sites) compared to control wounds (10 ulcers/16 sites) in a pig model.
   Background and Objectives: Extravasation of doxorubicin hydrochloride (Adriamycin) frequently causes chronic ulcers, which usually progress and expose underlying structures such as tendons and bone. The exact mechanism of action that causes cell death and the chronic ulcers is unknown.
   Methods: Eight sites were injected intradermally with doxorubicin on each of 4 pigs. Four sites on each animal served as untreated controls. The remaining four sites were exposed to 125 mm Hg subatmospheric pressure applied 1 h after injection. The sites were observed on a three times per week schedule. Sites that did not develop ulcers were re-injected up to a total of four injections. The animals were observed for 5 weeks.
   Results: Ten of sixteen control sites developed ulcers. No subatmospheric pressure treated sites developed ulcers. The incidence of ulcer formation was significantly less for treated wounds compared to control wounds at P < 0.001 by Fisher's exact test.
   Conclusions: This physical modality appears to successfully prevent ulcer formation after doxorubicin injection. (C) 1999 Wiley-Liss, Inc.
C1 Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
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NR 25
TC 26
Z9 34
U1 0
U2 1
PU WILEY-LISS
PI NEW YORK
PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA
SN 0022-4790
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD SEP
PY 1999
VL 72
IS 1
BP 14
EP 17
DI 10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3.0.CO;2-3
PG 4
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 237FC
UT WOS:000082643800004
PM 10477870
OA Bronze
DA 2026-07-24
ER

PT J
AU Morykwas, MJ
   David, LR
   Schneider, AM
   Whang, C
   Jennings, DA
   Canty, C
   Parker, D
   White, WL
   Argenta, LC
AF Morykwas, MJ
   David, LR
   Schneider, AM
   Whang, C
   Jennings, DA
   Canty, C
   Parker, D
   White, WL
   Argenta, LC
TI Use of subatmospheric pressure to prevent progression of
   partial-thickness burns in a swine model
SO JOURNAL OF BURN CARE & REHABILITATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; INHIBITION; INJURY
AB The poorly understood, complex series of events that follows thermal injury frequently results in progressive loss of tissue. The concept of reversing this distinctive series of events has focused on the zone of stasis. Tissues in the zone of stasis that surround burn injuries usually die over a period of 48 to 72 hours postinjury, resulting in a more severe injury. Application of a controlled subatmospheric pressure (125 mm Hg) in an artificially closed space to partial-thickness burns in pigs significantly decreased the maximum depth of cellular death under the burn when the pressure was applied within 12 hours after burn creation (depth of control burns = 0.885 +/- 0.115 mm; subatmospheric pressure treated burns (0-hour delay) = 0.095 +/- 0.025 mm). A decrease in the depth of cell death was noted when subatmospheric pressure was applied for as little as 6 hours. In summary, the application of the negative pressure to partial-thickness burn injuries prevented progression of the wound to a deeper injury in this experimental pig model. A 12-hour working window exists between injury and treatment with reduced pressure, with an application time of as Little as 6 hours for successful prevention of injury progression. This technique may represent a new, inexpensive, 'low tech' method for the treatment of partial-thickness burn injuries.
C1 Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
   Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University
RP Morykwas, MJ (通讯作者)，Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
OI Morykwas, Michael/0009-0001-5547-5172
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NR 25
TC 102
Z9 123
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0273-8481
J9 J BURN CARE REHABIL
JI J. Burn Care Rehabil.
PD JAN-FEB
PY 1999
VL 20
IS 1
BP 15
EP 21
DI 10.1097/00004630-199901001-00003
PN 1
PG 7
WC Emergency Medicine; Rehabilitation; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Rehabilitation; Surgery
GA 161BH
UT WOS:000078267700003
PM 9934631
DA 2026-07-24
ER

PT J
AU Parveen, K
   Hussain, MA
   Anwar, S
   Elagib, HM
   Kausar, MA
AF Parveen, Kehkashan
   Hussain, Malik Asif
   Anwar, Sadaf
   Elagib, Halima Mustafa
   Kausar, Mohd Adnan
TI Comprehensive review on diabetic foot ulcers and neuropathy: Treatment,
   prevention and management
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetic foot ulcers; Diabetic neuropathy; Diabetes mellitus; Peripheral
   neuropathy; Charcot neuroarthropathy
ID PERIPHERAL ARTERIAL-DISEASE; LOWER-EXTREMITY AMPUTATION;
   VASCULAR-SURGERY; WOUND REPAIR; RISK-FACTORS; FOLLOW-UP; EPIDEMIOLOGY;
   DYSFUNCTION; ULCERATION; FOCUS
AB Diabetic foot (DF) is a major public health concern. As evident from numerous previous studies, supervision of DF ulcer (DFU) is crucial, and a specific quality check-up is needed. Patients should be educated about glycaemic management, DFUs, foot lesions, proper care for injuries, diet, and surgery. Certain reasonably priced treatments, such as hyperbaric oxygen and vacuum-assisted closure therapy, are also available for DFUs, along with modern wound care products and techniques. Nonetheless, DF care (cleaning, applying antimicrobial cream when wounded, and foot reflexology), blood glucose monitoring to control diabetes, and monthly or quarterly examinations in individuals with diabetes are effective in managing DFUs. Between 50% and 80% of DF infections are preventable. Regardless of the intensity of the lesion, it needs to be treated carefully and checked daily during infection. Tissue regeneration can be aided by cleaning, dressing, and application of topical medicines. The choice of shoes is also important because it affects blood circulation and nerve impulses. In general, regular check-ups, monitoring of the patient's condition, measuring blood glucose levels, and providing frequent guidance regarding DFU care are crucial. Finally, this important clinical problem requires involvement of multiple professionals to properly manage it.
C1 [Parveen, Kehkashan] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Aligarh 202002, Uttar Pradesh, India.
   [Hussain, Malik Asif] Univ Hail, Coll Med, Dept Pathol, Hail 53962, Saudi Arabia.
   [Anwar, Sadaf; Kausar, Mohd Adnan] Univ Hail, Coll Med, Dept Biochem, Univ City Hail,Al Khitah St, Hail 53962, Saudi Arabia.
   [Elagib, Halima Mustafa] Univ Hail, Dept Pharmacol, Hail 53962, Saudi Arabia.
C3 Aligarh Muslim University; University Ha'il; University Ha'il;
   University Ha'il
RP Kausar, MA (通讯作者)，Univ Hail, Coll Med, Dept Biochem, Univ City Hail,Al Khitah St, Hail 53962, Saudi Arabia.
EM ma.kausar@uoh.edu.sa
RI Kausar, Mohd Adnan/AAE-9758-2020; Elagib, Halima/ADB-6898-2022; Anwar,
   Sadaf/ABC-9660-2021; Parveen, Kehkashan/GQH-9443-2022; Hussain, Malik
   Asif/ABD-2752-2021
OI Kausar, Mohd Adnan/0000-0002-8931-9290; Elagib,
   Halima/0000-0002-7291-7649; 
FU King Salman Center for Disability Research [KSRG-2023-407]
FX Supported by the King Salman Center for Disability Research, No.
   KSRG-2023-407.
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NR 104
TC 32
Z9 43
U1 7
U2 30
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD MAR 15
PY 2025
VL 16
IS 3
AR 100329
DI 10.4239/wjd.v16.i3.100329
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Z7E6U
UT WOS:001440496900021
PM 40093290
OA Green Accepted, gold
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Du, JP
   Gao, XC
   Hao, DJ
   Quan, ZX
   Yan, L
   He, BR
AF Du, Jinpeng
   Gao, Xiangcheng
   Hao, Dingjun
   Quan, Zhengxue
   Yan, Liang
   He, Baorong
TI Retrospective analysis of 10 cases with esophageal fistula after
   anterior surgery for cervical spine fracture
SO HELIYON
LA English
DT Article
DE Anterior surgery; Complication; Esophageal fistula; Spine fracture
ID PERFORATION; MANAGEMENT; COMPLICATION; INJURY; REPAIR
AB Objective: This study aims to discuss the appropriate treatment of esophageal fistula following anterior surgery for cervical spine fracture. Methods: Clinical data of patients with cervical spine fracture treated at our research center from January 2000 to December 2019 were screened. Data of patients with esophageal fistula were included, and the causes of injury, diagnosis, and treatment were retrospectively analyzed. Results: A total of 3578 patients with cervical spine fracture were screened, among whom there were 10 cases (0.28 %) of esophageal fistula. 60 % of the cases were early-onset and all were caused by intraoperative electric knife injury. The positive rate of early endoscopy was only 25 %, while routine radiography showed a positive rate of 33.3 % after three attempts. Among the six patients with early-onset esophageal fistula, three underwent sternocleidomastoid flap transfer and two underwent primary suture, all achieving successful healing. In the four cases of late-onset esophageal fistula, two patients received implant removal, debridement, incision lavage, and sternocleidomastoid muscle flap transfer three weeks later. One patient received implant removal, debridement, vacuum sealing drainage, followed by sternocleidomastoid muscle pedicle transfer muscle flap plus lavage two weeks later and achieved complete recovery. All patients gargled alternately with metronidazole and chlorhexidine gargle after surgery. Conclusion: The occurrence of esophageal fistula is associated with surgical procedures, esophageal injury, and implant compression. Esophagography and endoscopy are the primary diagnostic methods, while incision exploration after ingestion of food mixed with methylene serves as a supplementary approach. Recommended treatments include alternating metronidazole and chlorhexidine gargles, esophageal rest, repair of the fistula, muscle flap packing, lavage and drainage, nutritional support, and removal of internal fixation if necessary. Post-surgery administration of antibiotics should continue until three consecutive lavage cultures yield negative results.
C1 [Du, Jinpeng; Gao, Xiangcheng; Hao, Dingjun; Yan, Liang; He, Baorong] Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Friendship East Rd, Xian, Shaanxi, Peoples R China.
   [Quan, Zhengxue] Chongqing Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Chongqing, Peoples R China.
C3 Xi'an Jiaotong University; Chongqing Medical University
RP Yan, L; He, BR (通讯作者)，Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Friendship East Rd, Xian, Shaanxi, Peoples R China.
EM yanliangdr5583@163.com; hebaorongteacher@126.com
RI Gao, Xiangcheng/GPS-7824-2022
OI Gao, Xiangcheng/0000-0001-8522-5580
FU Science and Technology Commission of Xi' an [21YXYG0024, 23YXYJ0083];
   Science and Technology Association of Shaanxi [2021PSLK32]
FX This study was funded by the Project from the Science and Technology
   Commission of Xi' an (21YXYG0024, 23YXYJ0083) and Science and Technology
   Association of Shaanxi (2021PSLK32).
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NR 26
TC 1
Z9 2
U1 0
U2 4
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2023
VL 9
IS 11
AR e21244
DI 10.1016/j.heliyon.2023.e21244
EA OCT 2023
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z4DX4
UT WOS:001111609100001
PM 37908714
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wen, G
   Wang, CY
   Chai, YM
   Cheng, L
   Chen, M
   Lv, YM
AF Wen, Gen
   Wang, Chun-Yang
   Chai, Yi-Min
   Cheng, Liang
   Chen, Ming
   Lv, Yi-Min
TI DISTALLY BASED SAPHENOUS NEUROCUTANEOUS PERFORATOR FLAP COMBINED WITH
   VAC THERAPY FOR SOFT TISSUE RECONSTRUCTION AND HARDWARE SALVAGE IN THE
   LOWER EXTREMITIES
SO MICROSURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE THERAPY; NEGATIVE-PRESSURE;
   MUSCULOCUTANEOUS FLAP; CLINICAL-EXPERIENCE; TIBIAL FRACTURES;
   SPINAL-FUSION; ISLAND FLAP; FREE MUSCLE; COVERAGE
AB The complex wound with the exposed hardware and infection is one of the common complications after the internal fixation of the tibia fracture. The salvage of hardware and reconstruction of soft tissue defect remain challenging. In this report, we presented our experience on the use of the distally based saphenous neurocutaneous perforator flap combined with vacuum-assisted closure ( VAC) therapy for the coverage of the soft tissue defect and the exposed hardware in the lower extremity with fracture. Between January 2008 and July 2010, seven patients underwent the VAC therapy followed by transferring a reversed saphenous neurocutaneous perforator flap for reconstruction of the wound with exposed hardware around the distal tibia. The sizes of the flaps ranged from 6 x 3 cm to 15 x 6 cm. Six flaps survived completely. Partial necrosis occurred in one patient. There were no other complications of repair and donor sites. Bone healing was achieved in all patients. In conclusion, the reversed saphenous neurocutaneous perfortor flaps combined with the VAC therapy might be one of the options to cover the complex wound with exposed hardware in the lower extremities. (C) 2013 Wiley Periodicals, Inc.
C1 [Wen, Gen; Wang, Chun-Yang; Chai, Yi-Min; Cheng, Liang; Chen, Ming; Lv, Yi-Min] Jiao Tong Univ, Dept Orthoped Surg, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China.
C3 Shanghai Jiao Tong University
RP Chai, YM (通讯作者)，Jiao Tong Univ, Dept Orthoped Surg, Shanghai Peoples Hosp 6, 600 YiShan Rd, Shanghai 200233, Peoples R China.
EM chaiyimin@gmail.com
RI 文, 根/JWP-9726-2024
FU Science and Technology Commission of Shanghai Municipality Program
   [11JC1409400]
FX Grant sponsor: Science and Technology Commission of Shanghai
   Municipality Program; grant number: 11JC1409400.
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NR 41
TC 16
Z9 22
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV
PY 2013
VL 33
IS 8
BP 625
EP 630
DI 10.1002/micr.22162
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 296LJ
UT WOS:000330186200008
PM 23946231
DA 2026-07-24
ER

PT J
AU Gould, L
   Abadir, P
   Brem, H
   Carter, M
   Conner-Kerr, T
   Davidson, J
   DiPietro, L
   Falanga, V
   Fife, C
   Gardner, S
   Grice, E
   Harmon, J
   Hazzard, WR
   High, KP
   Houghton, P
   Jacobson, N
   Kirsner, RS
   Kovacs, EJ
   Margolis, D
   McFarland Horne, F
   Reed, MJ
   Sullivan, DH
   Thom, S
   Tomic-Canic, M
   Walston, J
   Whitney, JA
   Williams, J
   Zieman, S
   Schmader, K
AF Gould, Lisa
   Abadir, Peter
   Brem, Harold
   Carter, Marissa
   Conner-Kerr, Teresa
   Davidson, Jeff
   DiPietro, Luisa
   Falanga, Vincent
   Fife, Caroline
   Gardner, Sue
   Grice, Elizabeth
   Harmon, John
   Hazzard, William R.
   High, Kevin P.
   Houghton, Pamela
   Jacobson, Nasreen
   Kirsner, Robert S.
   Kovacs, Elizabeth J.
   Margolis, David
   McFarland Horne, Frances
   Reed, May J.
   Sullivan, Dennis H.
   Thom, Stephen
   Tomic-Canic, Marjana
   Walston, Jeremy
   Whitney, Jo Anne
   Williams, John
   Zieman, Susan
   Schmader, Kenneth
TI Chronic Wound Repair and Healing in Older Adults: Current Status and
   Future Research
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Review
DE chronic wound; pressure ulcer; diabetic foot ulcer; venous leg ulcer;
   wound repair; wound healing
ID VENOUS LEG ULCERS; HUMAN ALLOGENEIC FIBROBLASTS; PERIPHERAL
   VASCULAR-DISEASE; RANDOMIZED CONTROLLED-TRIAL; HYPERBARIC-OXYGEN
   THERAPY; LOW-FREQUENCY ULTRASOUND; VACUUM-ASSISTED CLOSURE; DIABETIC
   FOOT ULCERS; APPLIED CELL THERAPY; STEM-CELL
AB Older adults are more likely to have chronic wounds than younger people, and the effect of chronic wounds on quality of life is particularly profound in this population. Wound healing slows with age, but the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The effect of age and accompanying multimorbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables; lack of standardization in data collection; and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this article, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify research questions to guide future study of age-associated changes in chronic wound healing.
C1 [Gould, Lisa] Kent Hosp, Wound Recovery & Hyperbar Med Ctr, Warwick, RI USA.
   [Abadir, Peter; Walston, Jeremy] Johns Hopkins Univ, Div Geriatr & Gerontol Med, Baltimore, MD USA.
   [Brem, Harold] Winthrop Univ Hosp, Dept Wound Healing & Regenerat Med, Mineola, NY 11501 USA.
   [Brem, Harold] SUNY Stony Brook, Sch Med, Mineola, NY USA.
   [Carter, Marissa] Strateg Solut Inc, Cody, WY USA.
   [Conner-Kerr, Teresa] Winston Salem State Univ, Dept Phys Therapy, Winston Salem, NC USA.
   [Davidson, Jeff] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA.
   [DiPietro, Luisa] Univ Illinois, Ctr Wound Healing & Tissue Regenerat, Chicago, IL USA.
   [Falanga, Vincent] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA.
   [Fife, Caroline] Baylor Coll Med, Dept Geriatr, Houston, TX 77030 USA.
   [Fife, Caroline] St Lukes Wound Ctr, The Woodlands, TX USA.
   [Gardner, Sue] Univ Iowa, Coll Nursing, Iowa City, IA 52242 USA.
   [Grice, Elizabeth] Univ Penn, Penn Inst Immunol, Philadelphia, PA 19104 USA.
   [Harmon, John] Johns Hopkins Univ, Dept Surg, Baltimore, MD USA.
   [Hazzard, William R.] Wake Forest Univ, Sch Med, Gerontol & Geriatr Med, Winston Salem, NC 27109 USA.
   [High, Kevin P.] Wake Forest Univ, Sch Med, Dept Internal Med, Winston Salem, NC 27109 USA.
   [High, Kevin P.] Wake Forest Univ, Sch Med, Infect Dis Sect, Winston Salem, NC 27109 USA.
   [Houghton, Pamela] Univ Western Ontario, Sch Phys Therapy, London, ON, Canada.
   [Jacobson, Nasreen] Smith & Nephew, Ft Worth, TX USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Kovacs, Elizabeth J.] Loyola Univ, Burn & Shock Trauma Res Inst, Dept Surg, Chicago, IL 60611 USA.
   [Margolis, David] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
   [McFarland Horne, Frances] Assoc Specialty Professors, Alexandria, VA USA.
   [Reed, May J.] Univ Washington, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA.
   [Sullivan, Dennis H.] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72205 USA.
   [Thom, Stephen] Univ Maryland, Dept Emergency Med, Baltimore, MD 21201 USA.
   [Tomic-Canic, Marjana] Univ Miami, Miller Sch Med, Wound Healing & Regenerat Med Res Program, Miami, FL 33136 USA.
   [Walston, Jeremy] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Whitney, Jo Anne] Univ Washington, Sch Nursing, Seattle, WA 98195 USA.
   [Williams, John; Zieman, Susan] NIA, Bethesda, MD 20892 USA.
   [Schmader, Kenneth] Durham Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Durham, NC USA.
   [Schmader, Kenneth] Duke Univ, Med Ctr, Durham, NC USA.
C3 Johns Hopkins University; Winthrop University Hospital; State University
   of New York (SUNY) System; Stony Brook University; Winston-Salem State
   University; Vanderbilt University; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   Boston University; Baylor College of Medicine; University of Iowa;
   University of Pennsylvania; Johns Hopkins University; Wake Forest
   University; Wake Forest University; Wake Forest University; Western
   University (University of Western Ontario); Smith & Nephew; University
   of Miami; Loyola University Chicago; University of Pennsylvania;
   University of Washington; University of Washington Seattle; University
   of Arkansas System; University of Arkansas Medical Sciences; University
   System of Maryland; University of Maryland Baltimore; University of
   Miami; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; University of Washington; University of Washington
   Seattle; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); Geriatric Research Education & Clinical
   Center; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Durham VA Medical Center; Duke University
RP Gould, L (通讯作者)，Kent Mem Hosp, Wound Recovery & Hyperbar Med Ctr, 455 Tollgate Rd, Warwick, RI 02886 USA.
EM lgould44@hotmail.com
RI ; Abadir, Peter/A-2067-2017
OI Grice, Elizabeth/0000-0003-3939-2200; Harmon, John/0000-0002-2857-3850;
   Margolis, David/0000-0002-0506-8085; Schmader,
   Kenneth/0000-0001-5036-2155; Abadir, Peter/0000-0002-8186-0066; Kovacs,
   Elizabeth/0000-0002-9459-9928; Gardner, Sue/0000-0001-6224-6944;
   Tomic-Canic, Marjana/0000-0002-9341-0193
FU National Institute on Aging [1 U13 AG040938 01]; John A. Hartford
   Foundation; National Institute on Aging [P30AG021334, P30AG028716]
   Funding Source: NIH RePORTER
FX This workshop was supported by generous grants to ASP from the National
   Institute on Aging (1 U13 AG040938 01) and the John A. Hartford
   Foundation. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of National Institute
   on Aging or the National Institutes of Health (NIH). In addition, the
   views expressed in written conference materials or publications and by
   speakers or moderators do not necessarily reflect the official policies
   of the Department of Health and Human Services; nor does mention by
   trade names, commercial practices, or organizations imply endorsement by
   the U.S. government. We are grateful to Nancy Woolard for her assistance
   with organizing the workshop. To see the agenda, a list of workshop
   moderators and attendees, and workshop presentations, please visit
   http://www.im.org/p/cm/ld/fid=599.
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NR 137
TC 433
Z9 536
U1 4
U2 285
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAR
PY 2015
VL 63
IS 3
BP 427
EP 438
DI 10.1111/jgs.13332
PG 12
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA CE3PO
UT WOS:000351740400002
PM 25753048
DA 2026-07-24
ER

PT J
AU Shiroff, AM
   Herlitz, GN
   Gracias, VH
AF Shiroff, Adam M.
   Herlitz, Georg N.
   Gracias, Vicente H.
TI Necrotizing Soft Tissue Infections
SO JOURNAL OF INTENSIVE CARE MEDICINE
LA English
DT Article
DE Necrotising soft tissue infection; superantigen
ID RESISTANT STAPHYLOCOCCUS-AUREUS; LABORATORY RISK INDICATOR;
   VACUUM-ASSISTED CLOSURE; HYPERBARIC-OXYGEN; TOXIN PRODUCTION; FASCIITIS;
   MORTALITY; MANAGEMENT; DIAGNOSIS; THERAPY
AB Necrotising soft tissue infection (NSTI) presents unique challenges in diagnosis and management. The key to a successful outcome is a high index of suspicion in appropriate clinical settings. Type II NSTI tends to occur on an extremity in younger, healthier patients with a history of known trauma, and to be monomicrobial. Type I NSTI tends to occur on the trunk of older, less healthy patients without an obvious history of trauma, and tends to be polymicrobial. Other, rarer types exist as well. The pathophysiology of both types involves superantigen acticivty, as well as a number of microbial byproducts which collectively decrease the viscosity of pus, facilitating its spread along deep tissue planes and ultimately causing diffuse deep thrombosis and aggressive systemic sepsis. The most important physical finding is tenderness to palpation beyond the area of redness, and the lack of crepitus should not be seen as a reassuring sign. Suspected cases should undergo early surgical exploration for diagnosis, which may be performed at bedside through a small incision. Most imaging techniques are not sufficiently specific to warrant a delay in surgical exploration. The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) shows promise as a tool for excluding suspected cases. Successful outcomes in cases of NSTI require early and aggressive serial debridement and a multidisciplinary critical care approach.
C1 [Shiroff, Adam M.; Herlitz, Georg N.; Gracias, Vicente H.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Div Acute Care Surg, New Brunswick, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Shiroff, AM (通讯作者)，Div Acute Care Surg, 89 French St, New Brunswick, NJ 08901 USA.
EM shirofam@umdnj.edu
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NR 60
TC 37
Z9 45
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0885-0666
EI 1525-1489
J9 J INTENSIVE CARE MED
JI J. Intensive Care Med.
PD MAY
PY 2014
VL 29
IS 3
BP 138
EP 144
DI 10.1177/0885066612463680
PG 7
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AG1XS
UT WOS:000335210100003
PM 23753218
DA 2026-07-24
ER

PT J
AU Agostini, T
   Dini, M
   Li, AQ
   Grassetti, L
   Mori, A
   Spinelli, G
   Lo Russo, G
   Lazzeri, D
AF Agostini, Tommaso
   Dini, Mario
   Li, Alessandro Quattrini
   Grassetti, Luca
   Mori, Andrea
   Spinelli, Giuseppe
   Lo Russo, Giulia
   Lazzeri, Davide
TI A novel combined surgical approach to head and neck dermatofibrosarcoma
   protuberans
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Dermatofibrosarcoma protuberans; Head and neck; Vacuum-assisted closure;
   Dermal regenerative template; Skin graft
ID MICROSURGICAL RECONSTRUCTION; SUBATMOSPHERIC PRESSURE; INTEGRA; SURGERY;
   SKIN; DEFECTS; REGION
AB Introduction: The surgical management of dermatofibrosarcoma protuberans has historically been a challenge, particularly in the head and neck and other aesthetic areas. The current priority is to achieve local oncologic control and a good reconstructive outcome. Here, we present our experience using a novel combined approach with a dermal regenerative template, sub-atmospheric pressure and skin graft.
   Materials and methods: Five patients presenting at the Department of Plastic and Reconstructive Surgery of the University of Florence between January 2010 and October 2011 were included in the study following Institutional Review Board approval. All patients underwent a wide local excision of dermatofibrosarcoma protuberans affecting the head and neck.
   Results: The combined approach using the negative-pressure device, a dermal regenerative template and skin grafting proved effective in the management of this type of sarcoma with a good aesthetic and functional outcome, particularly on the neck or the supraclavicular region.
   Conclusion: Although the present multi-step technique requires patient compliance, it results in good local oncologic control of the resection margins. It is possible to perform a wider excision in the event of positive margins without interfering with the last reconstructive outcome. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Agostini, Tommaso; Dini, Mario; Li, Alessandro Quattrini; Mori, Andrea; Lo Russo, Giulia] Univ Florence, CTO AOUC, Dept Plast & Reconstruct, I-50134 Florence, Italy.
   [Agostini, Tommaso; Spinelli, Giuseppe] Univ Florence, CTO AOUC, Dept Maxillo Facial Surg, I-50121 Florence, Italy.
   [Lazzeri, Davide] Hosp Cisanello, Dept Plast & Reconstruct Surg, Pisa, Italy.
C3 University of Florence; University of Florence
RP Agostini, T (通讯作者)，Univ Florence, Fac Med, CTO AOUC, Dept Plast & Reconstruct Surg, Largo Palagi 1, I-50100 Florence, Italy.
EM tommasoagostini@ymail.com
RI Agostini, Tommaso/G-5688-2011
OI Agostini, Tommaso/0000-0001-6743-5218; Grassetti,
   Luca/0000-0002-8856-7997
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   Stiefel D, 2009, J PEDIATR SURG, V44, P575, DOI 10.1016/j.jpedsurg.2008.07.006
   Szollosi Z, 2007, J CLIN PATHOL, V60, P190, DOI 10.1136/jcp.2006.037200
   Tayeb T, 2011, J CRANIO MAXILL SURG, V39, P496, DOI 10.1016/j.jcms.2010.03.026
NR 18
TC 15
Z9 17
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD OCT
PY 2013
VL 41
IS 7
BP 681
EP 685
DI 10.1016/j.jcms.2013.01.009
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 236YI
UT WOS:000325835000025
PM 23485484
DA 2026-07-24
ER

PT J
AU Hallock, GG
AF Hallock, Geoffrey G.
TI The pectoralis major muscle extended island flap for complete
   obliteration of the median sternotomy wound
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE pectoralis major; rectus abdominis muscle flaps; median sternotomy wound
   infection
ID VACUUM-ASSISTED CLOSURE; ABDOMINIS DONOR-SITE; STERNAL WOUNDS;
   ADVANCEMENT FLAPS; MANAGEMENT; COVERAGE
AB The sequence of adverse events initiated by a sternal wound infection today can typically be ameliorated by interposing a vascularized flap. The pectoralis major muscle due to its propinquity has universally been the workhorse flap for minimizing this dilemma, with our experience over the past 25 years being no exception as 123 of 156 patients so inflicted required this donor site in some format. However, a rectus abdominis muscle had to be used in combination in 22 patients, particularly for coverage of the xiphoid region, and this can add significant morbidity in an already compromised patient population. This conundrum provided the impetus starting in 2003 for the development of a pectoralis major muscle extended island flap, whereby skeletonizing its vascular pedicle back to near the origin of the thoracoacromial axis, the desired extended reach can be obtained. Since that time, 18 pectoralis major muscle extended island flaps have been successfully used, with only a single wound complication still requiring use of a rectus abdominis muscle flap. This has proven to be a reliable option that alone allows complete closure of the median sternotomy wound while avoiding the need for combined flaps with preservation of the rectus abdominis muscle.
C1 Lehigh Valley Hosp Ctr, Div Plast Surg, Allentown, PA USA.
   Sacred Heart Hosp, Allentown, PA USA.
   St Lukes Hosp, Bethlehem, PA USA.
C3 Lehigh Valley Hospital
RP Hallock, GG (通讯作者)，1230 S Cedar Crest Blvd,Suite 306, Allentown, PA 18103 USA.
EM pbhallock@cs.com
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NR 21
TC 10
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD DEC
PY 2007
VL 59
IS 6
BP 655
EP 658
DI 10.1097/SAP.0b013e318049e6d5
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 235JE
UT WOS:000251229000012
PM 18046148
DA 2026-07-24
ER

PT J
AU Chiang, IH
   Wang, CH
   Tzeng, YS
AF Chiang, I-Han
   Wang, Chih-Hsin
   Tzeng, Yuan-Sheng
TI Surgical treatment and strategy in patients with multiple pressure sores
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE flaps; multiple pressure sores; strategy
ID VACUUM ASSISTED CLOSURE; ARTERY PERFORATOR FLAP; WOUND THERAPY; THIGH
   FLAP; RECONSTRUCTION; MANAGEMENT; ULCERS; COVERAGE; EFFICACY; OUTCOMES
AB Pressure sores remain a common health problem, particularly among the physically limited or bedridden elderly, and can cause significant morbidity and mortality. This study aimed to present our surgical treatment and strategy for patients with multiple pressure sores. Between January 2010 and December 2016, 18 patients were enrolled. After adequate debridement, pressure sores were managed based on our treatment protocol. Patients' age, aetiology, defect size and location, flap reconstruction, outcome, and follow-up period were reviewed. A total of 10 men and 8 women (average age, 82.3 years) with a mean follow-up period of 28.3 months (6-72 months) were included. The mean defect area was 63.7 cm(2). The most common aetiology of the bedridden state was cerebrovascular accident (38.89%), and the most frequent sores were trochanteric pressure sores (53.57%). The average operative time and blood loss were 105.5 minutes and 100.8 mL, respectively. No haemodynamic variation or blood transfusion was noted during the surgery. The complication rate for each sore was 10.7%, including late recurrence. In conclusion, treating pressure ulcers requires careful patient education, intensive multidisciplinary optimisation, and meticulous wound care, and our treatment protocol ensures a shorter surgery time, less bleeding, and low complication rate.
C1 [Chiang, I-Han; Wang, Chih-Hsin; Tzeng, Yuan-Sheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University
RP Tzeng, YS (通讯作者)，Triserv Gen Hosp, Dept Surg, Div Plast Surg & Reconstruct Surg, 325,Sect 2,Cheng Kung Rd, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI Tzeng, Yuan-sheng/AAD-8843-2020
FU Tri-Service General Hospital, ROC [TSGH-C107-117]; National Defense
   Medical Center
FX Dr. Y.-S. T. acknowledges the financial support for this work provided
   by National Defense Medical Center and Tri-Service General Hospital, ROC
   (TSGH-C107-117).
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NR 28
TC 9
Z9 10
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2018
VL 15
IS 6
BP 900
EP 908
DI 10.1111/iwj.12942
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GZ7ES
UT WOS:000449641000006
PM 29956467
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhao, JC
   Zhang, BR
   Shi, K
   Yu, JA
   Wang, J
   Yu, QH
   Hong, L
AF Zhao, Jing-Chun
   Zhang, Bo-Ru
   Shi, Kai
   Yu, Jia-Ao
   Wang, Jian
   Yu, Qing-Hua
   Hong, Lei
TI Couple-kissing flaps for successful repair of severe sacral pressure
   ulcers in frail elderly patients
SO BMC GERIATRICS
LA English
DT Article
DE Pressure ulcer; Sacrum; Surgical flaps; Elderly patients
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; CARE; PREVALENCE; PREVENTION;
   MANAGEMENT; UNIT
AB Background: Surgical repair of severe pressure ulcers (PUs) in elderly patients remains a challenge for clinicians due to the complicated comorbidities and the special physical characteristics of elderly patients. The objective of this study was to evaluate the application of couple-kissing flaps (CKF) in the reconstruction of sacral PUs in these patients.
   Methods: Elderly patients (over 70 years) with stage 3 or stage 4 PUs who underwent CKF immediately after radical debridement between July 2012 and December 2015 were enrolled in this retrospective study. Patients' demographics were extracted from the medical records.
   Results: A total of 12 patients were involved in this study. The average age of the patients was 76.83 years (ranged from 71 to 92 years). The donor site was closed primarily in all cases. All the flaps healed uneventfully without complications. Follow-up observations were conducted for an average of 13.6 months (ranged from 9 months to 2 years). Cosmetic results were satisfactory, with no surgical site breakdown or recurrence of PU in any of the cases. Three representative cases are presented.
   Conclusions: The CKF is a reliable and satisfactory option for the reconstruction of severe sacral PUs defects in elderly patients. CKF is associated with an relatively low rate of complications and recurrence.
C1 [Zhao, Jing-Chun; Zhang, Bo-Ru; Shi, Kai; Yu, Jia-Ao; Wang, Jian; Yu, Qing-Hua; Hong, Lei] Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University
RP Yu, JA (通讯作者)，Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM bu_dong007@163.com
RI wang, jian/GVS-0711-2022
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NR 34
TC 8
Z9 10
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD DEC 11
PY 2017
VL 17
AR 285
DI 10.1186/s12877-017-0680-4
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FP8EF
UT WOS:000417872500001
PM 29228903
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lee, SL
   Tejirian, T
   Abbas, MA
AF Lee, Steven L.
   Tejirian, Tatar
   Abbas, Maher A.
TI Current management of adolescent pilonidal disease
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 59th Annual Meeting of the American-Academy-of-Pediatrics
CY OCT 27-30, 2007
CL San Francisco, CA
SP Amer Acad Pediat
DE pediatric pilonidal disease; wide local excision; unroofing and
   marsupialization
ID VACUUM-ASSISTED CLOSURE; WOUND MANAGEMENT; SINUS DISEASE;
   MARSUPIALIZATION; EXPERIENCE; EXCISION
AB Background: Controversy persists regarding the optimal management for adolescent pilonidal disease. We reviewed the outcome of wide local excision (WLE) vs unroofing and marsupialization (UM) for pilonidal disease.
   Methods: A retrospective review 2002 to 2007 of adolescents undergoing surgical treatment of pilonidal disease was performed. Data were analyzed using Student's t test.
   Results: Twenty-six patients were treated for pilonidal disease during this period. Average age was 16.7 years (range, 14-19 years) with 50% males. Nine patients underwent WLE and 17 had UM. Before initial evaluation, 44% of patients in the WLE group had drainage of acute abscess compared to 59% in the UM group (P >.05). Postoperative complications in the WLE group (78%) were significantly higher compared to the UM group (0%). Median time for final healing was significantly higher in the WLE group (32 weeks) compared to the UM group (6 weeks). The reoperative rate was also significantly higher in the WLE group (56%) compared, to the UM group (0%). No patient had recurrent disease after complete healing in either group.
   Conclusion: Unroofing and marsupialization for primary pilonidal disease has a shorter time to heal and carries a lower complication and reoperative rate compared to WLE. (C) 2008 Elsevier Inc. All rights reserved.
C1 Kaiser Permanente, Los Angeles Med Ctr, Dept Surg, Los Angeles, CA 90027 USA.
   Kaiser Permanente, Los Angeles Med Ctr, Div Pediat Surg, Los Angeles, CA 90272 USA.
   Kaiser Permanente, Los Angeles Med Ctr, Div Colorectal Surg, Los Angeles, CA 90272 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Kaiser Permanente;
   Kaiser Permanente; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; Kaiser
   Permanente
RP Lee, SL (通讯作者)，Kaiser Permanente, Los Angeles Med Ctr, Dept Surg, Los Angeles, CA 90027 USA.
EM steven.l.lee@kp.org
CR Abbas MA, 2006, DIS COLON RECTUM, V49, P1242, DOI 10.1007/s10350-006-0617-z
   Bascom J, 2002, ARCH SURG-CHICAGO, V137, P1146, DOI 10.1001/archsurg.137.10.1146
   Buie E.A, 2014, CHI 14 HUM FACT COMP
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NR 18
TC 46
Z9 49
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JUN
PY 2008
VL 43
IS 6
BP 1124
EP 1127
DI 10.1016/j.jpedsurg.2008.02.042
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA 326CR
UT WOS:000257636000039
PM 18558194
DA 2026-07-24
ER

PT J
AU Zeng, QM
   Cai, GP
   Liu, DC
   Wang, K
   Zhang, XC
AF Zeng, Qingmin
   Cai, Guoping
   Liu, Dechang
   Wang, Kun
   Zhang, Xinchao
TI Successful Salvage of the Upper Limb After Crush Injury Requiring Nine
   Operations: A Case Report
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Trauma; Upper limb; Crush injury
ID VACUUM-ASSISTED CLOSURE; EXTREMITY SEVERITY SCORE; DEGLOVING INJURY;
   MANAGEMENT; FRACTURES; FIXATION; VALIDITY; SKIN
AB Emergency treatment of amputation is one of the most frequently used therapeutic methods for patients with severe upper limb crush injury with a mangled extremity severity score (MESS) of more than 7. With the development of advanced surgical repair techniques and reconstructive technology, cases that once required amputation can now be salvaged with appropriate management, and some limb functions may also be reserved. A patient with a severe upper limb crush injury with a MESS score of 10 was treated in our hospital. The limb was salvaged after 9 surgeries over 10 months. The follow-up visits over the next 18 months post-injury showed that the shoulder joint functions were rated as "excellent" (90) according to the Neer score, the Harris hip evaluation (HHS) for elbow joint functions was "good" (80), and the patient was very satisfied with the overall therapeutic outcome. We conclude from the successful outcome of this extreme injury that salvage attempts should be the first management choice for upper limbs with complex injuries to save as much function as possible. Amputation should only be adopted when the injury is life-threatening or no more function can be saved. The level of evidence was V.
C1 [Zeng, Qingmin; Cai, Guoping; Liu, Dechang; Wang, Kun; Zhang, Xinchao] Fudan Univ, Jinshan Hosp, Dept Orthoped, Shanghai 201508, Peoples R China.
C3 Fudan University
RP Zhang, XC (通讯作者)，Fudan Univ, Jinshan Hosp, Dept Orthoped, 1508 Longhang Rd, Shanghai 201508, Peoples R China.
EM zhangxc410@aliyun.com
CR Arnez ZM, 2010, J PLAST RECONSTR AES, V63, P1865, DOI 10.1016/j.bjps.2009.11.029
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NR 20
TC 1
Z9 2
U1 0
U2 7
PU INT COLLEGE OF SURGEONS
PI CHICAGO
PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAR
PY 2015
VL 100
IS 3
BP 540
EP 546
DI 10.9738/INTSURG-D-14-00018.1
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE2RX
UT WOS:000351665100027
PM 25785341
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU van Koperen, PJ
   van der Zaag, ES
   Omloo, JMT
   Slors, JFM
   Bemelman, WA
AF van Koperen, P. J.
   van der Zaag, E. S.
   Omloo, J. M. T.
   Slors, J. F. M.
   Bemelman, W. A.
TI The persisting presacral sinus after anastomotic leakage following
   anterior resection or restorative proctocolectomy
SO COLORECTAL DISEASE
LA English
DT Article
DE Anastomotic leakage; rectal surgery; sinus; ileostomy
ID TOTAL MESORECTAL EXCISION; VACUUM-ASSISTED CLOSURE; RECTAL-CANCER
   SURGERY; RISK-FACTORS; IMPACT
AB Aim
   Despite improvements in anastomotic technique, anastomotic leakage is frequently encountered following anterior resection. This can eventually evolve into a presacral sinus. This study assessed the incidence, the natural course and the outcome of persisting presacral sinus.
   Method
   Patients who underwent low anterior resection (LAR) for cancer or restorative proctocolectomy (RPC) for ulcerative colitis or familial polyposis were eligible. Patients with anastomotic leakage or a presacral abscess were included. Outcome parameters included a persistent presacral sinus, or its closure and average time to closure and the stoma closure rate.
   Results
   Twenty-five patients were identified with a sinus after LAR (n = 20) or RPC (n = 5). A persistent sinus was present in nine (1%) of 834 patients after LAR and two (0.9%) of 229 patients after RPC. Definitive resolution of the sinus occurred in 12 (52%) of 23 assessable patients. This was achieved at a median of 340 days (range 23-731 days). At final follow-up, nine of the 23 patients had permanent faecal diversion because of recurrent abscess or persistent sinus formation, seven after LAR and two after RPC.
   Conclusion
   A significant proportion of patients with anastomotic leakage after rectal surgery develop a chronic sinus, of which only half heal over time. Persisting sinus is the main reason for a permanent stoma.
C1 [van Koperen, P. J.; Slors, J. F. M.; Bemelman, W. A.] Acad Med Ctr, Dept Surg, NL-1100 DD Amsterdam, Netherlands.
   [van Koperen, P. J.; van der Zaag, E. S.; Omloo, J. M. T.] Gelre Hosp, Dept Surg, Apeldoorn, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Gelre
   Hospitals
RP Bemelman, WA (通讯作者)，Acad Med Ctr, Dept Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM w.a.bemelman@amc.uva.nl
RI Bemelman, Wilhelmus/AAA-1635-2021
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NR 15
TC 40
Z9 43
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2011
VL 13
IS 1
BP 26
EP 29
DI 10.1111/j.1463-1318.2010.02377.x
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 700SU
UT WOS:000285765400004
PM 20649900
DA 2026-07-24
ER

PT J
AU Vargo, D
   Richardson, JD
   Campbell, A
   Chang, M
   Fabian, T
   Franz, M
   Kaplan, M
   Moore, F
   Reed, RL
   Scott, B
   Silverman, R
AF Vargo, Daniel
   Richardson, J. David
   Campbell, Andre
   Chang, Michael
   Fabian, Timothy
   Franz, Michael
   Kaplan, Mark
   Moore, Frederick
   Reed, R. Lawrence
   Scott, Bradford
   Silverman, Ronald
CA Open Abdomen Advisory Panel
TI Management of the Open Abdomen: From Initial Operation to Definitive
   Closure
SO AMERICAN SURGEON
LA English
DT Review
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; ACELLULAR
   DERMAL MATRIX; MULTIPLE ORGAN FAILURE; FLUID RESUSCITATION STRATEGIES;
   LONG-TERM COMPLICATIONS; DAMAGE-CONTROL; FASCIAL CLOSURE; TRAUMA
   PATIENTS; WITTMANN PATCH
AB The open abdomen is a relatively new and increasingly common strategy for the management of abdominal emergencies in both trauma and general surgery. The use of an abbreviated laparotomy can reduce mortality associated with conditions such as abdominal compartment syndrome; however, the resulting open abdomen is a complex clinical problem. Modern techniques and technologies are now available that allow for improved management of the open abdomen and the progressive reduction of the fascial defect. Indeed, recent evidence indicates that a large proportion of patients treated with open abdomen can now be closed within the initial hospitalization. These techniques and technologies include the appropriate use of negative pressure therapy and synthetic or biologic repair materials. It is essential that general and trauma surgeons understand the core principles underlying the need for and management of the open abdomen. Toward this goal, an Open Abdomen Advisory Panel was established to identify core principles in the management of the open abdomen and to develop a set of recommendations based on the best available evidence. This review presents the principles and recommendations identified by the Open Abdomen Advisory Panel and provides brief case studies for the illustration of these concepts.
C1 [Richardson, J. David] Univ Louisville, Dept Surg, Louisville, KY 40202 USA.
C3 University of Louisville
RP Richardson, JD (通讯作者)，Univ Louisville, Dept Surg, 550 S Jackson St, Louisville, KY 40202 USA.
EM Jdrich01@louisville.edu
RI /AAJ-2575-2020; Silverman, Ronald/A-5155-2018; Chang,
   Michael/JXN-0401-2024
FU Kinetic Concepts, Inc., San Antonio, TX
FX Funding for the Open Abdomen Advisory Panel, editorial assistance and
   manuscript preparation was provided by the Wound Healing and LifeCell
   divisions of Kinetic Concepts, Inc., San Antonio, TX. Editorial support
   was provided by Medisys Health Communications, High Bridge, NJ. Writing
   assistance was provided by Joshua Kilbridge of Kilbridge Associates, San
   Francisco, CA.
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NR 110
TC 112
Z9 118
U1 0
U2 9
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2009
VL 75
IS 11
SU S
BP S1
EP S22
PG 22
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 513QA
UT WOS:000271336700001
PM 19998714
DA 2026-07-24
ER

PT J
AU Oliveira, A
   Simoes, S
   Ascenso, A
   Reis, CP
AF Oliveira, Andre
   Simoes, Sandra
   Ascenso, Andreia
   Reis, Catarina Pinto
TI Therapeutic advances in wound healing
SO JOURNAL OF DERMATOLOGICAL TREATMENT
LA English
DT Review
DE Wound healing; skin regeneration; new and more cost-effective
   technologies; therapies
ID SHOCK-WAVE THERAPY; DIABETIC FOOT ULCER; VACUUM-ASSISTED CLOSURE;
   EPIDERMAL-GROWTH-FACTOR; SKIN SUBSTITUTES; SILVER NANOPARTICLES; GOLD
   NANOPARTICLES; HYPERBARIC-OXYGEN; DOUBLE-BLIND; ANTIBACTERIAL ACTIVITY
AB Wound healing is a complex physiological process that occurs in the human body involving the sequential activation of multiple cell types and signaling pathways in a coordinated manner. Chronic wounds and burns clearly decrease quality of life of the patients since they are associated with an increase in physical pain and socio-economical complications. Furthermore, incidence and prevalence of chronic wounds (unlike burns) have been increasing mainly due to population aging resulting in increased costs for national health systems. Thus, the development of new and more cost-effective technologies/therapies is not only of huge interest but also necessary to improve the long-term sustainability of national health systems. This review covers the current knowledge on recent technologies/therapies for skin regeneration, such as: wound dressings; skin substitutes; exogenous growth factor based therapy and systemic therapy; external tissue expanders; negative pressure; oxygen; shock wave, and photobiomodulation wound therapies. Associated benefits and risks as well as the clinical use and availability are all addressed for each therapy. Moreover, future trends in wound care including novel formulations using metallic nanoparticles and topical insulin are herein presented. These novel formulations have shown to be promising therapeutic options in the near future that may change the wound care paradigm.
C1 [Oliveira, Andre] Univ Lisbon, Fac Pharm, Lisbon, Portugal.
   [Simoes, Sandra; Ascenso, Andreia; Reis, Catarina Pinto] Univ Lisbon, Res Inst Med, Fac Pharm, iMed ULisboa, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Reis, Catarina Pinto] Univ Lisbon, IBEB, Fac Sci Biophys & Biomed Engn, Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Lisboa
RP Reis, CP (通讯作者)，Univ Lisbon, Res Inst Med, Fac Pharm, iMed ULisboa, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM catarinareis@ff.ulisboa.pt
RI Reis, Catarina/M-8132-2013; ascenso, aneia/K-5978-2014; Simões,
   Sandra/AAN-9865-2021
OI Reis, Catarina/0000-0002-1046-4031; ascenso, aneia/0000-0002-8727-0614;
   Simões, Sandra/0000-0002-5685-1790
FU Fundacao para a Ciencia e Tecnologia (FCT) [UID/DTP/04138/2019]; FCT
   Sabbatical Leave Fellowships (BSAB) [SFRH/BSAB/150315/2019]
FX This research was funded by Fundacao para a Ciencia e Tecnologia (FCT)
   under the Reference UID/DTP/04138/2019 and FCT Sabbatical Leave
   Fellowships (BSAB) attributed to Andreia Ascenso with Reference
   SFRH/BSAB/150315/2019.
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   2019, WOUNDS COMPENDIUM CL
NR 204
TC 126
Z9 148
U1 1
U2 92
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-6634
EI 1471-1753
J9 J DERMATOL TREAT
JI J. Dermatol. Treat.
PD JAN 2
PY 2022
VL 33
IS 1
BP 2
EP 22
DI 10.1080/09546634.2020.1730296
EA FEB 2020
PG 21
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YY6OD
UT WOS:000517038400001
PM 32056472
DA 2026-07-24
ER

PT J
AU Wetzel-Roth, W
   Zöch, G
AF Wetzel-Roth, W
   Zöch, G
TI Consensus of the German and Austrian Societies for Wound Healing and
   Wound Management on vacuum closure and the VAC® treatment unit
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Country Congress on VAC Therapy for Outpatients as well as
   In-Hospital Patients
CY MAY 21-22, 2003
CL Mainz, GERMANY
DE Wound Management; vacuum closure; VAC((R)) treatment
AB Within the framework of the Three-Country Congress on V.A.C.(R) Treatment (Vacuum Assisted Closure Treatment) held on May 16/17, 2003 in Salzburg, a Consensus Conference involving members of the Committees of the German and Austrian Societies for Wound Management was convened. In view of the divergence of opinion on the effectiveness of the treatment among the cost carriers, it appeared appropriate for the two Societies for Wound Healing in Germany and Austria to arrive at a consensus on the importance of and the indications for the management of wounds with the vacuum closure method. Since the first clinical applications in the nineteen-forties, both the indication spectrum and the number of applications have increased continually. In addition to diverse vacuum closure systems, there is patented computer-controlled system technology available that is established V.A.C.(R) treatment. Although this is a hospital-based system, it can also be used on an outpatient basis by appropriately trained physicians and nursing staff and in instructed patients. For some indications, vacuum closure and V.A.C.(R) management is considered the treatment of choice, since no equivalent alternative methods are available. A con-benefit analysis shows that vacuum closure and V.A.C.(R) treatment is cost effective.
C1 DGFW, D-35392 Giessen, Germany.
RP Wetzel-Roth, W (通讯作者)，Hindenburgstr 1, D-86807 Buchloe, Germany.
EM dr.walter.wetzel-roth@onlinemed.de
NR 0
TC 11
Z9 18
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
J9 ZBL CHIR
JI Zent.bl. Chir.
PD MAY
PY 2004
VL 129
SU 1
BP S7
EP S11
DI 10.1055/s-2004-822677
PG 5
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 826GF
UT WOS:000221816600004
PM 15168274
DA 2026-07-24
ER

PT J
AU Wang, KJ
   Wang, YC
   Shi, WL
   Shen, K
   Tao, K
   Ling, R
   Huang, YS
   Fu, XB
   Hu, DH
AF Wang, Kejia
   Wang, Yunchuan
   Shi, Wenlong
   Shen, Kuo
   Tao, Ke
   Ling, Rui
   Huang, Yuesheng
   Fu, Xiaobing
   Hu, Dahai
TI Diagnosis and treatment of diabetic foot ulcer complicated with lower
   extremity vasculopathy: Consensus recommendation from the Chinese
   Medical Association (CMA), Chinese Medical Doctor Association (CMDA)
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE bypass surgery; debridement; diabetic foot ulcer; endovascular therapy;
   lower extremity vasculopathy; microcirculation disturbance
ID PERIPHERAL ARTERIAL-DISEASE; MAGNETIC-RESONANCE ANGIOGRAPHY;
   LIMB-THREATENING ISCHEMIA; VACUUM-ASSISTED CLOSURE;
   CLASSIFICATION-SYSTEM; MAJOR AMPUTATION; VASCULAR-DISEASE; WOUND
   THERAPY; REVASCULARIZATION; MANAGEMENT
AB Diabetic foot ulcer complicated with lower extremity vasculopathy is highly prevalent, slow healing and have a poor prognosis. The final progression leads to amputation, or may even be life-threatening, seriously affecting patients' quality of life. The treatment of lower extremity vasculopathy is the focus of clinical practice and is vital to improving the healing process of diabetic foot ulcers. Recently, a number of clinical trials on diabetic foot ulcers with lower extremity vasculopathy have been reported. A joint group of Chinese Medical Association (CMA) and Chinese Medical Doctor Association (CMDA) expert representatives reviewed and reached a consensus on the guidelines for the clinical diagnosis and treatment of this kind of disease. These guidelines are based on evidence from the literature and cover the pathogenesis of diabetic foot ulcers complicated with lower extremity vasculopathy and the application of new treatment approaches. These guidelines have been put forward to guide practitioners on the best approaches for screening, diagnosing and treating diabetic foot ulcers with lower extremity vasculopathy, with the aim of providing optimal, evidence-based management for medical personnel working with diabetic foot wound repair and treatment.
C1 [Wang, Kejia; Wang, Yunchuan; Shen, Kuo; Hu, Dahai] Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian, Shaanxi, Peoples R China.
   [Shi, Wenlong; Ling, Rui] Air Force Med Univ, Xijing Hosp, Dept Thyroid Breast & Vasc Surg, Xian, Shaanxi, Peoples R China.
   [Tao, Ke] Wenzhou Med Univ, Affiliated Hosp 1, Wound Repair & Regenerat Med Ctr, Dept Wound Repair, Wenzhou, Zhejiang, Peoples R China.
   [Huang, Yuesheng] Southern Univ Sci & Technol, Southern Univ Sci & Technol Hosp, Inst Wound Repair & Regenerat Med, Sch Med,Dept Wound Repair, Shenzhen, Peoples R China.
   [Fu, Xiaobing] Peoples Liberat Army Gen Hosp, Res Ctr Tissue Repair & Regenerat, Med Innovat Res Dept, Beijing, Peoples R China.
   [Fu, Xiaobing] Peoples Liberat Army Gen Hosp, Med Ctr 4, Shenzhen, Peoples R China.
   [Fu, Xiaobing] PLA Med Coll, Beijing, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Wenzhou
   Medical University; Southern University of Science & Technology; Chinese
   People's Liberation Army General Hospital; Chinese People's Liberation
   Army General Hospital
RP Hu, DH (通讯作者)，Air Force Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian, Shaanxi, Peoples R China.; Huang, YS (通讯作者)，Southern Univ Sci & Technol, Southern Univ Sci & Technol Hosp, Inst Wound Repair & Regenerat Med, Sch Med,Dept Wound Repair, Shenzhen, Peoples R China.; Fu, XB (通讯作者)，Peoples Liberat Army Gen Hosp, Res Ctr Tissue Repair & Regenerat, Med Innovat Res Dept, Beijing, Peoples R China.
EM yshuangtmmu@163.com; fuxiaobing@vip.sina.com; hudhai@fmmu.edu.cn
FU National Natural Science Foundation of China; National Natural Science
   Foundation of China (NFSC); Chinese Medical Association; Chinese Medical
   Doctor Association
FX The authors thank Xiaobing Fu, academician of Chinese Academy of
   Engineering, for helpful discussions during the development of the
   study. Dr. Fu received no financial support for his participation. A
   number of academic colleagues from CMA and CMDA for their helpful
   reviews and assistance. Janisa and Tina (staff members of Freescience)
   assisted with the execution of figures and tables. This activity was
   funded by the National Natural Science Foundation of China (NFSC), the
   Chinese Medical Association and the Chinese Medical Doctor Association.
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NR 82
TC 28
Z9 31
U1 15
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB 25
PY 2024
VL 40
IS 3
AR e3776
DI 10.1002/dmrr.3776
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JJ3B2
UT WOS:001172747600001
PM 38402455
OA hybrid
DA 2026-07-24
ER

PT J
AU Eckmann, C
AF Eckmann, Christian
TI The importance of source control in the management of severe skin and
   soft tissue infections
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE complicated skin and soft tissue infections; necrotizing soft tissue
   infections; soft tissue sepsis; source control; surgical treatment
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; HYPERBARIC-OXYGEN;
   COMPLICATED SKIN; THERAPY; GUIDELINES; IMMUNOGLOBULIN; EPIDEMIOLOGY;
   TIGECYCLINE; DIAGNOSIS
AB Purpose of reviewRecent studies mainly deal with the relevance of antibiotics in the treatment of complicated skin and soft tissue infections (cSSTIs) with or without sepsis. The impact of surgical source control for severely ill patients with sepsis is underrepresented in the literature. This review tries to add new information on this topic.Recent findingsSource control in cSSTI ranges from removal of central venous catheters to radical debridement of extensive body areas. Necrotizing soft tissue infections serve as a model disease for the value of surgical measures in severe cSSTI. Early diagnosis and timing of surgical intervention, the necessary extent of surgery and the assessment of adjunctive therapies (hyperbaric oxygenation, intravenous immunoglobulins) have been recently investigated.SummaryThe evidence for simple source control measures (i.e., opening and drainage of an abscess) remains low, but appears to be self-evident. Radical debridement remains the standard of care for those patients with soft tissue sepsis because of necrotizing soft tissue infections. Surgical treatment should be performed latest within 12h after admission. The value of other adjunctive measures (hyperbaric oxygen therapy, intravenous immunoglobulins) is uncertain. Only an aggressive approach offers the possibility to save life and limbs of the affected patients.
C1 [Eckmann, Christian] Hannover Med Sch, Acad Hosp, Klinikum Peine, Dept Gen Visceral & Thorac Surg, Virchowstr 8h, D-31226 Peine, Germany.
C3 Hannover Medical School
RP Eckmann, C (通讯作者)，Hannover Med Sch, Acad Hosp, Klinikum Peine, Dept Gen Visceral & Thorac Surg, Virchowstr 8h, D-31226 Peine, Germany.
EM christian.eckmann@klinikum-peine.de
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NR 36
TC 26
Z9 31
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD APR
PY 2016
VL 29
IS 2
BP 139
EP 144
DI 10.1097/QCO.0000000000000240
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA DG1KK
UT WOS:000371826400006
PM 26779777
DA 2026-07-24
ER

PT J
AU Li, HY
   Wang, ZX
   Wang, JC
   Zhang, XD
AF Li, He-Yun
   Wang, Zhi-Xiang
   Wang, Jian-Chun
   Zhang, Xiao-Di
TI Clostridium perfringens gas gangrene caused by closed
   abdominal injury: A case report and review of the literature
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Clostridium perfringens; Intra-abdominal infection; Gas gangrene; Open
   abdomen; Case report
AB BACKGROUNDAbdominal Clostridium perfringens (C. perfringens) gas gangrene is a rare infection that has been described in the literature as most frequently occurring in postoperative patients with open trauma. Intra-abdominal gas gangrene caused by C. perfringens infection after closed abdominal injury is extremely rare, difficult to diagnose, and progresses rapidly with high mortality risk. Here, we report a case of C. perfringens infection caused by closed abdominal injury.CASE SUMMARYA 54-year-old male suffered multiple intestinal tears and necrosis after sustaining an injury caused by falling from a high height. These injuries and the subsequent necrosis resulted in intra-abdominal C. perfringens infection. In the first operation, we removed the necrotic intestinal segment, kept the abdomen open and covered the intestine with a Bogota bag. A vacuum sealing drainage system was used to cover the outer layer of the Bogota bag, and the drainage was flushed under negative pressure. The patient was transferred to the intensive care unit for supportive care and empirical antibiotic treatment. The antibiotics were not changed until the results of bacterial culture and drug susceptibility testing were obtained. Two consecutive operations were then performed due to secondary intestinal necrosis. After three definitive operations, the patient successfully survived the perioperative period. Unfortunately, he died of complications related to Guillain-Barre syndrome 75 d after the first surgery. This paper presents this case of intra-abdominal gas gangrene infection and analyzes the diagnosis and treatment based on a review of current literature.CONCLUSIONWhen the intestines rupture leading to contamination of the abdominal cavity by intestinal contents, C. perfringens bacteria normally present in the intestinal tract may proliferate in large numbers and lead to intra-abdominal infection. Prompt surgical intervention, adequate drainage, appropriate antibiotic therapy, and intensive supportive care comprise the most effective treatment strategy. If the abdominal cavity is heavily contaminated, an open abdominal approach may be a beneficial treatment.
C1 [Li, He-Yun] Shaanxi Nucl Ind 215 Hosp, Dept Intens Care Unit, Xianyang 712000, Shaanxi, Peoples R China.
   [Wang, Zhi-Xiang; Zhang, Xiao-Di] Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
   [Wang, Jian-Chun] Shaanxi Nucl Ind 215 Hosp, Dept Healthcare associate Infect Management, Xianyang 712000, Shaanxi, Peoples R China.
   [Zhang, Xiao-Di] Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
RP Zhang, XD (通讯作者)，Shaanxi Nucl Ind 215 Hosp, Dept Gen Surg, Xianyang 712000, Shaanxi, Peoples R China.
EM zhangxd215@163.com
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NR 34
TC 2
Z9 3
U1 1
U2 5
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 6
PY 2023
VL 11
IS 4
BP 852
EP 858
DI 10.12998/wjcc.v11.i4.852
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9J4QV
UT WOS:000940174200013
PM 36818624
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Singh, DP
   Zahiri, HR
   Gastman, B
   Holton, LH
   Stromberg, JA
   Chopra, K
   Wang, HD
   Green, AC
   Silverman, RP
AF Singh, Devinder P.
   Zahiri, Hamid R.
   Gastman, Brian
   Holton, L. H., III
   Stromberg, Jeffrey A.
   Chopra, Karan
   Wang, Howard D.
   Green, Alexandra Conde
   Silverman, Ronald P.
TI A Modified Approach to Component Separation Using Biologic Graft as a
   Load-Sharing Onlay Reinforcement for the Repair of Complex Ventral
   Hernia
SO SURGICAL INNOVATION
LA English
DT Article
DE ventral hernia; components separation; Strattice; onlay reinforcement;
   load sharing
ID ABDOMINAL-WALL DEFECTS; ACELLULAR DERMAL MATRIX; PROGRESSIVE TENSION
   SUTURES; VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA; MESH REPAIR;
   SURGICAL-TREATMENT; RECONSTRUCTION; OUTCOMES; MODEL
AB Background. Components separation has been proposed as a means to close large ventral hernia without undue tension. We report a modification on open components separation that allows for the incorporation of onlaid noncrosslinked porcine acellular dermal matrix (Strattice, LifeCell Corp, Branchburg, NJ) as a load-sharing structure. Methods. This was a retrospective case series including all cases using Strattice from July 2008 through December 2009. Data evaluated included patient demographics, comorbidities associated with risk of recurrence, hernia grade, and postoperative complications. The primary outcomes were hernia recurrence and surgical site occurrences. Results. There were 58 patients; 60.8% presented with a recurrent incisional hernia. Average length of follow-up was 384 days. There were 4 hernia recurrences (7.9%). Complications included surgical site infection (20.7%), seroma (15.5%), and hematoma (5%) requiring intervention. Four deaths occurred in the series due to causes unrelated to the hernia repair, only 1 within 30 days of operation. Conclusions. This series demonstrates that components separation reinforced with noncrosslinked porcine acellular dermal matrix onlay is an efficacious, single-stage repair with a low rate of recurrence and surgical site occurrences.
C1 [Singh, Devinder P.; Zahiri, Hamid R.; Holton, L. H., III; Stromberg, Jeffrey A.; Chopra, Karan; Wang, Howard D.; Green, Alexandra Conde; Silverman, Ronald P.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Gastman, Brian] Cleveland Clin, Cleveland, OH 44106 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   Cleveland Clinic Foundation
RP Singh, DP (通讯作者)，Univ Maryland, Div Plast Surg, Sch Med, 22 South Greene St,S8D18, Baltimore, MD 21201 USA.
EM dsingh@smail.umaryland.edu
RI Singh, Devinder/AAN-4716-2021; Silverman, Ronald/A-5155-2018
FU LifeCell Corporation, Branchburg, New Jersey
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article:Funding for
   this study was provided by LifeCell Corporation, Branchburg, New Jersey.
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NR 52
TC 6
Z9 6
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2014
VL 21
IS 2
BP 137
EP 146
DI 10.1177/1553350613492585
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AF2WR
UT WOS:000334573700013
PM 23804996
OA hybrid
DA 2026-07-24
ER

PT J
AU Noh, SM
   Ahn, JY
   Lee, JH
   Jung, HY
   AlGhamdi, Z
   Kim, HR
   Kim, YH
AF Noh, Soo Min
   Ahn, Ji Yong
   Lee, Jeong Hoon
   Jung, Hwoon-Yong
   AlGhamdi, Zeead
   Kim, Hyeong Ryul
   Kim, Yong-Hee
TI Endoscopic Vacuum-Assisted Closure Therapy in Patients with Anastomotic
   Leakage after Esophagectomy: A Single-Center Experience
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID MANAGEMENT; RESECTION; FISTULAS; DRAINAGE
AB Aim. To study the efficacy of E-VAC therapy for patients with anastomotic leakage after esophagectomy. Methods. Between January 2013 and April 2017, 12 patients underwent E-VAC therapy for the management of postoperative leakage. Their clinical features and endoscopic procedure details, therapy results, adverse events, and survival were investigated. Results. All 12 patients were male and the median age was 57 years (interquartile range 51.5-62.8 years). The reasons for esophageal surgery were esophageal cancer (83.3%), gastrointestinal stromal tumor (8.3%), and esophageal diverticulum (8.3%). Prior to E-VAC therapy, 6 patients had undergone failed primary surgical repair and the median duration from esophagectomy to leakage discovery was 13.5 days (IQR 6-207 days). The median duration of E-VAC therapy was 25 days (IQR 13.5-34.8 days) and the average sponge exchange rate was 2.7 times during the treatment period. After E-VAC therapy, 8 patients (66.7%) had complete leakage closure, 3 (25%) had a decreased leakage size, and 1 (8.3%) was unchanged. The three patients with a decreased leakage size after E-VAC therapy were treated with endoscopic and conservative management without further surgery. Conclusion. With proper patient selection, E-VAC therapy is a feasible and safe method for the treatment of anastomotic leakage after esophagectomy.
C1 [Noh, Soo Min] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Internal Med, Seoul, South Korea.
   [Ahn, Ji Yong; Lee, Jeong Hoon; Jung, Hwoon-Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Gastroenterol, Seoul, South Korea.
   [AlGhamdi, Zeead; Kim, Hyeong Ryul; Kim, Yong-Hee] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center; University of Ulsan; Asan Medical Center
RP Ahn, JY (通讯作者)，Univ Ulsan, Coll Med, Asan Med Ctr, Asan Digest Dis Res Inst,Dept Gastroenterol, Seoul, South Korea.
EM ji110@hanmail.net
RI ALGHAMDI, ZEEAD/AFT-1593-2022; Ahn, Ji Yong/AGO-1695-2022
OI ALGHAMDI, ZEEAD/0000-0002-0096-4921; Ahn, Ji Yong/0000-0002-0030-3744; 
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NR 17
TC 28
Z9 31
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2018
VL 2018
AR 1697968
DI 10.1155/2018/1697968
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GD1OB
UT WOS:000430268500001
PM 29849581
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Saziye, K
   Afksendiyos, K
AF Saziye, Karaca
   Afksendiyos, Kalangos
TI The vacuum-assisted closure (VAC®) system for surgical site infection
   with involved vascular grafts
SO VASCULAR
LA English
DT Article
DE SSI; vascular graft infection; VAC; wound infection
ID RESISTANT STAPHYLOCOCCUS-AUREUS; TERM-FOLLOW-UP; NEGATIVE-PRESSURE;
   MANAGEMENT; GROIN; SURGERY; EXPERIENCE; THERAPY; IMPACT
AB Background: In vascular surgery, surgical site infection is the most common postoperative morbidity, occurring in 5-10% of vascular patients. The optimal management of surgical site infection with involved lower limb vascular grafts remains controversial. We present our 6-year results of using the V.A.C.((R)) system in surgical site infection with involved vascular grafts.
   Methods: A retrospective 6-year review of patient who underwent a VAC((R)) therapy for postoperative surgical site infection in lower limb with involved vascular grafts in our department between January 2006 and December 2011. V. A. C therapy was used in 40 patients. All patients underwent surgical wound revision with VAC((R)) therapy and antibiotics.
   Results: The mean time of use of the V. A. C. system was 14.2 days. After mean of 12 days in 34 of 40 patients, in whom the use of VAC((R)) therapy resulted in delayed primary closure or healing by secondary intention. The mean postoperative follow-up time was 61.67 months, during which 3 patients died.
   Conclusion: We showed that the V.A.C.((R)) system is valuable for managing specifically surgical site infection with involved vascular grafts. Using the V.A.C.((R)) system, reoperation rates are reduced; 85% of patients avoided graft replacement.
C1 [Saziye, Karaca; Afksendiyos, Kalangos] Univ Hosp Geneva, Dept Cardiovasc Surg, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva
RP Saziye, K (通讯作者)，Univ Hosp Geneva, Dept Cardiovasc Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM saziye.karaca@hcuge.ch
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NR 28
TC 8
Z9 9
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD APR
PY 2015
VL 23
IS 2
BP 144
EP 150
DI 10.1177/1708538114537488
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD3EP
UT WOS:000350961000006
PM 24879657
DA 2026-07-24
ER

PT J
AU Wong, CHK
   Senewiratne, S
   Garlick, B
   Mullany, D
AF Wong, Clement H. K.
   Senewiratne, Shireen
   Garlick, Bruce
   Mullany, Daniel
TI Two-stage management of sternal wound infection using bilateral
   pectoralis major advancement flap
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE sternum; mediastinal infection; wound dehiscence
ID VACUUM-ASSISTED CLOSURE; SINGLE-STAGE MANAGEMENT; CARDIAC-SURGERY;
   RETROSPECTIVE ANALYSIS; DELAYED CLOSURE; STERNOTOMY; COMPLICATIONS;
   MEDIASTINITIS; SYSTEM
AB Objective: To report our experience using two staged bilateral pectoralis major flap as the sole treatment modality for sternal wound infection. Methods: A retrospective study of 9417 open-heart surgery cases performed between 1998 and 2003 at The Prince Charles Hospital. Sixty-eight patients were referred to the plastic surgical team for consideration of bilateral pectoralis major flap as the sole treatment modality for sternal wound infection. Results: There was a trend for early referral for flap operation (median 10 days) (p = 0.49). The median postoperative ventilation time and ICU stay were 1 and 2 days, respectively. The median hospital stay after flap operation was 15.5 days. One-year overall survival was 91%. Ninety-five per cent heated stable sternum was achieved with 100% failure in patients with chronically unstable sternum. Early referral appears to be an important factor in preventing osteomyelitis formation (p = 0.05) with the longest recurrence at 10 months postoperatively. Conclusions: The key to the successful management of deep sternal wound infection is early referral for pectoralis major flap operation. Our approach is safe with good tong-term outcomes. We recommend this approach in all severe deep sternal wound infection but not in patients with chronic unstable sternum. (c) 2006 Elsevier B.V. All rights reserved.
C1 Prince Charles Hosp, Dept Cardiothorac & Plast Surg, Brisbane, Qld 4053, Australia.
   Prince Charles Hosp, Dept Intens Care Serv, Brisbane, Qld 4053, Australia.
C3 Prince Charles Hospital; Prince Charles Hospital
RP Wong, CHK (通讯作者)，1-11 Sir Fred Schonell Dr, St Lucia, Qld 4067, Australia.
EM clement-wong1@excite.com
RI mullany, dan/C-7927-2018
OI mullany, dan/0000-0002-9119-0676
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NR 21
TC 29
Z9 30
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUL
PY 2006
VL 30
IS 1
BP 148
EP 152
DI 10.1016/j.ejcts.2006.03.049
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 062GP
UT WOS:000238932900033
PM 16725333
DA 2026-07-24
ER

PT J
AU Mustoe, T
AF Mustoe, T
TI Understanding chronic wounds: a unifying hypothesis on their
   pathogenesis and implications for therapy
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT Symposium on Clinical Wound Healing of the Diabetic Foot Ulcer
CY DEC 14, 2001
CL New York, NY
SP NY Acad Med
ID GROWTH-FACTOR; HYPERBARIC-OXYGEN; ULCER MODEL; TELOMERASE; TENSION;
   ENHANCEMENT; SENESCENCE; INFECTION; CELLS
AB The development of new therapies for treatment of chronic wounds has not matched the availability of treatment modalities forecast by the pharmaceutical industry. This is attributable in large part to difficulties encountered in clinical trials as well as in isolating study design variables. Our hypothesis attempts to address this shortcoming. We are proposing that chronic wound pathogenesis is based on 3 fundamental factors: the cellular and systemic changes of aging, repeated ischemia-reperfusion injury, and bacterial colonization with resulting inflammatory host response. The derivation of this hypothesis is founded on the observation that the 3 primary categories of chronic wounds-pressure ulcers, diabetic ulcers, and venous ulcers, which are the overwhelming majority of chronic wounds-have these common causative factors. Our hypothesis incorporates major implications for treatment modalities based on these factors. Addressing the first issue, the cellular and systemic changes of aging, Regranex (Ortho-McNeil Pharmaceutical, Inc, Raritan, NJ), a platelet-derived growth factor drug, has shown great promise. Additional treatment modalities that address the second and third problems, repeated ischemia-reperfusion injury and bacterial colonization, include vacuum-assisted closure, warming of local tissue, and water irrigation using pulsed lavage. Additionally, treatment comprising a combination of these approaches has demonstrated success. (C) 2004 Excerpta Medica, Inc. All rights reserved.
C1 Northwestern Univ, Feinberg Sch Med, Dept Surg Plast Surg, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Mustoe, T (通讯作者)，Northwestern Univ, Feinberg Sch Med, Dept Surg Plast Surg, Galter 19-250,675 N St Clair St, Chicago, IL 60611 USA.
EM tmustoe@nmh.org
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NR 26
TC 320
Z9 412
U1 1
U2 32
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD MAY
PY 2004
VL 187
IS 5A
SU S
BP 65S
EP 70S
DI 10.1016/S0002-9610(03)00306-4
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 823GD
UT WOS:000221597200010
PM 15147994
DA 2026-07-24
ER

PT J
AU Drefs, M
   Schardey, J
   Von Ehrlich-Treuenstätt, V
   Wirth, U
   Burian, M
   Zimmermann, P
   Werner, J
   Kühn, F
AF Drefs, Moritz
   Schardey, Josefine
   Von Ehrlich-Treuenstaett, Viktor
   Wirth, Ulrich
   Burian, Maria
   Zimmermann, Petra
   Werner, Jens
   Kuehn, Florian
TI Endoscopic Treatment Options for Gastrointestinal Leaks
SO VISCERAL MEDICINE
LA English
DT Review
DE Gastrointestinal leakage; Endoscopy; Anastomotic leak; Endoscopic vacuum
   treatment; Endosponge
ID VACUUM-ASSISTED CLOSURE; LOW ANTERIOR RESECTION; POUCH-ANAL ANASTOMOSIS;
   ENDO-SPONGE TREATMENT; PORE FILM DRAINAGE; LONG-TERM EFFICACY;
   RECTAL-CANCER; HARTMANNS PROCEDURE; INTERNATIONAL CONSENSUS; COLORECTAL
   ANASTOMOSES
AB Background: Spontaneous or postoperative gastrointestinal defects are still life-threatening complications with elevated morbidity and mortality. Recently, endoscopic treatment options - up and foremost endoscopic vacuum therapy (EVT) - have become increasingly popular and have shown promising results in these patients. Methods: We performed an electronic systematic search of the MEDLINE databases (PubMed, EMBASE, and Cochrane) and searched for studies evaluating endoscopic options for the treatment of esophageal and colorectal leakages and/or perforations until March 2022. Results: The closure rate of both esophageal and colorectal defects by EVT is high and even exceeds the results of surgical revision in parts. Out of all endoscopic treatment options, EVT shows most evidence and appears to have the highest therapeutic success rates. Furthermore, EVT for both indications had a low rate of serious complications without relevant in-hospital mortality. In selected patients, EVT can be applied without fecal diversion and transferred to an outpatient setting. Conclusion: Despite multiple endoscopic treatment options, EVT is increasingly becoming the new gold standard in endoscopic treatment of extraperitoneal defects of the upper and lower GI tract with localized peritonitis or mediastinitis and without close proximity to major blood vessels. However, further prospective, comparative studies are needed to strengthen the current evidence.
C1 [Drefs, Moritz; Schardey, Josefine; Von Ehrlich-Treuenstaett, Viktor; Wirth, Ulrich; Burian, Maria; Zimmermann, Petra; Werner, Jens; Kuehn, Florian] Univ Hosp Munich, Dept Gen Visceral & Transplant Surg, Munich, Germany.
C3 University of Munich
RP Drefs, M (通讯作者)，Univ Hosp Munich, Dept Gen Visceral & Transplant Surg, Munich, Germany.
EM moritz.drefs@med.uni-muenchen.de
RI ; Schardey, Josefine/OWA-4498-2025
OI Burian, Maria/0000-0001-6710-1621; Drefs, Moritz/0000-0002-0662-7643;
   Kühn, Florian/0000-0001-9830-3015; Schardey,
   Josefine/0000-0002-7933-2977
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NR 110
TC 10
Z9 11
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD OCT
PY 2022
VL 38
IS 5
BP 311
EP 321
DI 10.1159/000526759
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 5Z8BF
UT WOS:000880191400003
PM 37970585
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Colosimo, C
   Yon, JR
   Fredericks, C
   Kingsley, S
   Gupta, S
   Mentzer, CJ
   Bokhari, F
   Poulakidas, S
AF Colosimo, Christina
   Yon, James R.
   Fredericks, Charles
   Kingsley, Samuel
   Gupta, Sameer
   Mentzer, Caleb J.
   Bokhari, Faran
   Poulakidas, Stathis
TI Obesity is Not Associated With Need for Skin Grafting After Hidradenitis
   Excision
SO AMERICAN SURGEON
LA English
DT Article
DE hidradenitis suppurativa; skin grafting; obesity
AB Introduction Hidradenitis suppurativa (HS) is a chronic, debilitating disease associated with inflammation, recurrent abscesses, and fistulae of skin containing apocrine sweat glands. We hypothesize that the need for skin grafting after vacuum-assisted closure was decreased with increasing body mass index (BMI). Methods Seventy-one consecutive patients with excisions for HS were retrospectively evaluated for demographic data, number of excisions, the total area of excised skin, need for skin grafting, and BMI. Patients were stratified for BMI and underwent logistic regression to compare all other variables. Results Average for BMI was 30.8 +/- 7.72, age was 36.89 +/- 13.52, area excised was 743 cm(2) +/- 774 cm(2), mean operating room trips were 2.62 +/- 1.59, and skin grafting was 0.52 +/- 0.55. Patients were 60% male. Forty out of 71 patients were obese. There was no correlation between age, BMI, sex, thenumber of excisions, amount of skin excised, or need for a skin graft. There was a statistically significant relationship between the amount of skin excised and the need for skin grafting (P = .006). Conclusions The amount of skin affected by HS appears to be independent of patient BMI. The need for skin grafting is solely dependent upon the amount of tissue excised. Applicability of research to practice This knowledge will help preoperative planning for all patients with HS, regardless of BMI.
C1 [Colosimo, Christina] Sky Ridge Med Ctr, Dept Trauma, Lone Tree, CO USA.
   [Yon, James R.] Swedish Med Ctr, Dept Trauma & Acute Care Surg, Englewood, CO 80110 USA.
   [Fredericks, Charles] UC Davis Med Ctr, Div Trauma Acute Care & Gen Surg, Sacramento, CA USA.
   [Kingsley, Samuel; Gupta, Sameer; Bokhari, Faran; Poulakidas, Stathis] John H Stroger Jr Hosp Cook Cty, Dept Trauma & Burn, Chicago, IL USA.
   [Mentzer, Caleb J.] Spartanburg Med Ctr, Div Trauma Crit Care & Acute Care Surg, Spartanburg, SC USA.
C3 University of California System; University of California Davis; John H
   Stroger Junior Hospital Cook County; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Colosimo, C (通讯作者)，Sky Ridge Med Ctr, Dept Trauma, 21775 Mt Elbert Pl, Parker, CO 80138 USA.
EM Chris.colosimo@gmail.com
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
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NR 29
TC 1
Z9 2
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD MAR
PY 2021
VL 87
IS 3
BP 458
EP 462
DI 10.1177/0003134820950686
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RK4JS
UT WOS:000638264300019
PM 33047967
DA 2026-07-24
ER

PT J
AU Eisenhardt, SU
   Eisenhardt, NA
   Thiele, JR
   Stark, B
   Bannasch, H
AF Eisenhardt, Steffen U.
   Eisenhardt, Nils A.
   Thiele, Jan R.
   Stark, Bjoern
   Bannasch, Holger
TI Salvage Procedures After Failed Facial Reanimation Surgery Using the
   Masseteric Nerve as the Motor Nerve for Free Functional Gracilis Muscle
   Transfer
SO JAMA FACIAL PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MICROSURGICAL RECONSTRUCTION; PALSY; PARALYSIS;
   SMILE; ADULTS; GRAFT
AB IMPORTANCE Free muscle transfer innervated by a cross-facial nerve graft represents the criterion standard for smile reconstruction in facial paralysis. If primary reconstruction fails, a second muscle transfer is usually needed. Herein, we investigated the possibility of avoiding a second free muscle transfer by in situ coaptation of the gracilis muscle to the masseteric nerve.
   OBSERVATIONS We report a series of 3 failed free muscle transfers for facial reanimation among 21 free flap transfers performed for facial reanimation between March 2008 and August 2013. To salvage the muscle, we performed coaptation of the neural pedicle from the cross-facial nerve graft to the masseteric nerve. This method allows for leaving the fixation sutures of the muscle at the oral commissure in place. All patients showed muscle contraction after 3 months and a smile with open mouth after 6 months. No significant difference in the range of commissure excursion was observed between the healthy and operated sides.
   CONCLUSIONS AND RELEVANCE Recoaptation of the neural pedicle from the cross-facial nerve graft to the masseteric nerve, leaving the muscle transplant in place, is a suitable salvage procedure after unsuccessful reconstruction with a cross-facial nerve graft, avoiding a second free muscle transfer.
C1 [Eisenhardt, Steffen U.; Thiele, Jan R.; Stark, Bjoern; Bannasch, Holger] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, D-79106 Freiburg, Germany.
   [Eisenhardt, Nils A.] Univ Tubingen Hosp, Dept Anesthesiol & Intens Care Med, Tubingen, Germany.
C3 University of Freiburg; Eberhard Karls University of Tubingen; Eberhard
   Karls University Hospital
RP Eisenhardt, SU (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM steffen.eisenhardt@uniklinik-freiburg.de
RI Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Eisenhardt, Steffen Ulrich/0000-0003-4471-3160
CR Bae YC, 2006, PLAST RECONSTR SURG, V117, P2407, DOI 10.1097/01.prs.0000218798.95027.21
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NR 15
TC 24
Z9 27
U1 0
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6076
EI 2168-6092
J9 JAMA FACIAL PLAST SU
JI JAMA Facial Plast. Surg.
PD SEP-OCT
PY 2014
VL 16
IS 5
BP 359
EP 363
DI 10.1001/jamafacial.2014.163
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP8VN
UT WOS:000342357500009
PM 24994013
DA 2026-07-24
ER

PT J
AU Lü, DY
   Liu, XF
   Gao, YX
   Huo, B
   Kang, YY
   Chen, J
   Sun, SJ
   Chen, L
   Luo, XD
   Long, MA
AF Lu, Dongyuan
   Liu, Xiaofeng
   Gao, Yuxin
   Huo, Bo
   Kang, Yingyong
   Chen, Juan
   Sun, Shujin
   Chen, Li
   Luo, Xiangdong
   Long, Mian
TI Asymmetric Migration of Human Keratinocytes under Mechanical Stretch and
   Cocultured Fibroblasts in a Wound Repair Model
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EPIDERMAL-GROWTH-FACTOR; GENE-EXPRESSION;
   FACTOR-ALPHA; TGF-ALPHA; SKIN; EPITHELIALIZATION; INDUCTION; EGF;
   DIFFERENTIATION
AB Keratinocyte migration during re-epithelization is crucial in wound healing under biochemical and biomechanical microenvironment. However, little is known about the underlying mechanisms whereby mechanical tension and cocultured fibroblasts or keratinocytes modulate the migration of keratinocytes or fibroblasts. Here we applied a tensile device together with a modified transwell assay to determine the lateral and transmembrane migration dynamics of human HaCaT keratinocytes or HF fibroblasts. A novel pattern of asymmetric migration was observed for keratinocytes when they were cocultured with non-contact fibroblasts, i.e., the accumulative distance of HaCaT cells was significantly higher when moving away from HF cells or migrating from down to up cross the membrane than that when moving close to HF cells or when migrating from up to down, whereas HF migration was symmetric. This asymmetric migration was mainly regulated by EGF derived from fibroblasts, but not transforming growth factor alpha or beta 1 production. Mechanical stretch subjected to fibroblasts fostered keratinocyte asymmetric migration by increasing EGF secretion, while no role of mechanical stretch was found for EGF secretion by keratinocytes. These results provided a new insight into understanding the regulating mechanisms of two- or three-dimensional migration of keratinocytes or fibroblasts along or across dermis and epidermis under biomechanical microenvironment.
C1 [Lu, Dongyuan; Liu, Xiaofeng; Gao, Yuxin; Huo, Bo; Kang, Yingyong; Chen, Juan; Sun, Shujin; Long, Mian] Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100080, Peoples R China.
   [Lu, Dongyuan; Liu, Xiaofeng; Gao, Yuxin; Huo, Bo; Kang, Yingyong; Chen, Juan; Sun, Shujin; Long, Mian] Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100080, Peoples R China.
   [Chen, Li; Luo, Xiangdong] Third Mil Med Univ, Southwest Hosp, Burn Res Inst, Chongqing, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Mechanics, CAS; Chinese
   Academy of Sciences; Institute of Mechanics, CAS; Army Medical
   University
RP Long, MA (通讯作者)，Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100080, Peoples R China.
EM mlong@imech.ac.cn
RI Huo, Bo/AAA-1331-2020
FU National Natural Science Foundation of China [30730032, 30730093,
   31000421, 30870601]; National Key Basic Research Foundation of China
   [2011CB710904]; National High Technology Research and Development
   Program of China [2011AA020109]; Chinese Academy of Sciences
   [KJCX2-YW-L08]; Scientific Research Equipment Project [Y2010030]
FX This work was supported by National Natural Science Foundation of China
   grants 30730032, 30730093, 31000421, and 30870601
   (http://www.nsfc.gov.cn/Portal0/default106.htm); National Key Basic
   Research Foundation of China grant 2011CB710904, and National High
   Technology Research and Development Program of China grant 2011AA020109
   (http://www.most.gov.cn/eng/index.htm), and Chinese Academy of Sciences
   Knowledge Innovation Program grant KJCX2-YW-L08 and Scientific Research
   Equipment Project of grant Y2010030 (http://english.cas.cn/). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 49
TC 36
Z9 42
U1 1
U2 34
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 23
PY 2013
VL 8
IS 9
AR e74563
DI 10.1371/journal.pone.0074563
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 246EK
UT WOS:000326520200036
PM 24086354
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Danner, BC
   Zenker, D
   Didilis, VN
   Grossmann, M
   Stojanovic, T
   Seipelt, R
   Tirilomis, T
   Schöndube, FA
AF Danner, B. C.
   Zenker, D.
   Didilis, V. N.
   Grossmann, M.
   Stojanovic, T.
   Seipelt, R.
   Tirilomis, T.
   Schoendube, F. A.
TI Transposition of Greater Omentum in Deep Sternal Wound Infection Caused
   by Methicillin-Resistant Staphylococci, with Differing Clinical Course
   for MRSA and MRSE
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article; Proceedings Paper
CT 39th Annual Meeting of the
   German-Society-for-Thoracic-and-Cardiovascular-Surgery
CY FEB 14-17, 2010
CL Stuttgart, GERMANY
SP German Soc Thorac & Cardiovasc Surg
DE cardiovascular surgery; thoracic surgery; omentum; MRSA; deep sternal
   wound infection
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS;
   POSTOPERATIVE MEDIASTINITIS; MANAGEMENT; FLAP; RECONSTRUCTION;
   COMPLICATIONS; THERAPY; AUREUS
AB Background: Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE) are an increasing problem in deep sternal wound infections (DSWI) after cardiac surgery.
   Methods: Between 2005 and 2009, recalcitrant methicillin-resistant Staphylococcus was found in 21 patients with complicated DSWI, and a transposition of the greater omentum (TGO) was finally performed. A positive microbial culture at the time of procedure was present in all patients. The hospital course was reviewed discretely for MRSA and MRSE.
   Results: Median patient age was 72.3 years (range 60.8-79.7); 76% of patients were male. Time from the first sternal revision until consecutive open wound therapy due to re-infection and total hospital stay was longer for MRSA compared to MRSE (38 vs. 14 days, p = 0.003, and 141 vs. 91 days, p = 0.007, respectively). The period from cardiac surgery to TGO was likewise prolonged for MRSA (78 vs. 55 days, p = 0.045), whereas in-hospital mortality and one-year mortality rate did not differ.
   Conclusion: TGO remains a good treatment option for DSWI type IV. Microbial findings determine the clinical course; nevertheless in-hospital mortality remains low for both MRSA and MRSE infection.
C1 [Danner, B. C.; Zenker, D.; Didilis, V. N.; Grossmann, M.; Stojanovic, T.; Seipelt, R.; Tirilomis, T.; Schoendube, F. A.] Univ Med Ctr, Dept Thorac & Cardiovasc Surg, D-37075 Gottingen, Germany.
C3 University of Gottingen; University of Gottingen Hospital
RP Danner, BC (通讯作者)，Univ Med Ctr, Dept Thorac & Cardiovasc Surg, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM bdanner@med.uni-goettingen.de
RI Tirilomis, Theodor/AEP-0737-2022
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NR 28
TC 6
Z9 9
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0171-6425
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD FEB
PY 2011
VL 59
IS 1
BP 21
EP 24
DI 10.1055/s-0030-1250373
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 707TE
UT WOS:000286310200004
PM 21243567
DA 2026-07-24
ER

PT J
AU Steenkamp, CJ
   Kong, VY
   Bruce, JL
   Laing, GL
   Clarke, DL
AF Steenkamp, C. J.
   Kong, V. Y.
   Bruce, J. L.
   Laing, G. L.
   Clarke, D. L.
TI A selective vacuum assisted mesh mediated fascial traction approach
   following temporary abdominal containment for trauma laparotomy is
   effective in achieving closure
SO SOUTH AFRICAN JOURNAL OF SURGERY
LA English
DT Article
DE Vacuum assisted closure; Surgical Meshes; Occlusive dressings; Surgical
   Closure Techniques; Ventral hernia
ID OPEN ABDOMEN; PACK TECHNIQUE
AB Background: Definitive primary abdominal closure is often not possible nor desirable following trauma laparotomy. In such situations. temporary abdominal containment (TAC) is necessary. This audit reviews our experience with TAC and interrogates our use of the Vacuum Assisted Mesh Mediated Fascia' Traction approach (VAMMFT) to achieve delayed closure of the Open Abdomen (OA).
   Methods: We conducted a retrospective study over a 4-year period of trauma patients who underwent a trauma laparotomy and who required a TAC.
   Results: Over the four-year period. 596 patients underwent a laparotomy for trauma. Of these trauma laparotomies, 463 (78%) underwent primary closure and 133 (22%) required a TAC. Of these 133 patients who required a TAC, 37 died, 41 underwent delayed primary fascial closure at repeat laparotomy and 55 were left with an OA. Of this cohort of 55 patients. 15 underwent a VAMMFT procedure. The VAMMFT procedure yielded a 60% closure rate. with failure to close being clue to late mesh insertion and sepsis.
   Conclusion: Our initial results with VAMMFT are encouraging. The technique appears to be effective and safe. Ongoing audit will allow us to accrue more patients and to better refine our algorithms and strategies.
C1 [Steenkamp, C. J.; Kong, V. Y.; Bruce, J. L.; Laing, G. L.] Univ KwaZulu Natal, Dept Surg, Pietermaritzburg Metropolitan Trauma Serv, Durban, South Africa.
   [Clarke, D. L.] Univ Witwatersrand, Dept Surg, Johannesburg, South Africa.
C3 University of Kwazulu Natal; University of Witwatersrand
RP Steenkamp, CJ (通讯作者)，Univ KwaZulu Natal, Dept Surg, Pietermaritzburg Metropolitan Trauma Serv, Durban, South Africa.
EM christiensteenkamp@yahoo.co.uk
RI ; KONG, VICTOR/J-1762-2014; Laing, Grant/QJU-5653-2026
OI Kong, Victor/0000-0003-2291-2572; Clarke, Damian/0000-0002-8467-1455; 
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NR 14
TC 5
Z9 6
U1 0
U2 1
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0038-2361
EI 2078-5151
J9 S AFR J SURG
JI South Afr. J. Surg.
PD DEC
PY 2018
VL 56
IS 4
BP 28
EP +
DI 10.17159/2078-5151/2018/v56n4a2674
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI0JU
UT WOS:000456128700006
OA gold
DA 2026-07-24
ER

PT J
AU Harris, CL
   Holloway, S
AF Harris, Connie L.
   Holloway, Samantha
TI Development of an evidence-based protocol for care of pilonidal sinus
   wounds healing by secondary intent using a modified reactive Delphi
   procedure. Part one: the literature review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Consensus; Items affecting healing; Pilonidal sinus disease; Pilonidal
   sinus wounds
ID VACUUM-ASSISTED CLOSURE; CADEXOMER IODINE; DISEASE; EXCISION;
   MICROBIOLOGY; ANTISEPTICS; MANAGEMENT; INFECTION; DRESSINGS; THERAPY
AB This article is in two parts. The overall aim of this section was to review the literature in relation to pilonidal sinus wounds (PSW) healing by secondary intent for a Master's of Science in Wound Healing and Tissue Repair thesis. The purpose of the literature review was to determine if an evidence-based guideline or consensus document existed for the care of these wounds, and if not, to determine the topics from which to develop items for the first round of a modified reactive Delphi questionnaire. Part two will describe the iterative process, the analysis and the results. The review found no best practice guidelines concerning PSW, and only one clinical pathway. Seventeen areas of interest were identified that may contribute to optimal healing conditions or to delayed healing. These included microbiology of infected PSW, signs and symptoms of localised or deeper (spreading) chronic wound infection, swab for c&s, role of topical antiseptics or antimicrobials, systemic antibiotics, local wound interventions, optimal positioning, wound cleansing, principles of moist wound healing/dressing selection, topical negative pressure (TNP) therapy, peri-wound skin decontamination and depilation, pain control, physical activities, optimal nutrition and patient education.
C1 [Harris, Connie L.] CarePartners, Waterloo, ON N2V 2C9, Canada.
   [Holloway, Samantha] Cardiff Univ, Dept Dermatol & Wound Healing, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Harris, CL (通讯作者)，CarePartners, Unit B 207 151 Frobisher Dr, Waterloo, ON N2V 2C9, Canada.
EM connie.harris@carepartners.ca
OI Holloway, Samantha/0000-0002-3307-8248
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NR 116
TC 16
Z9 17
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 156
EP 172
DI 10.1111/j.1742-481X.2011.00874.x
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900009
PM 21999659
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Taheri, A
   Mansoori, P
   Sharif, M
AF Taheri, Arash
   Mansoori, Parisa
   Sharif, Mohammad
TI Wound Debridement in Pyoderma Gangrenosum
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE biofilm; debridement; necrotic; pathergy; pyoderma gangrenosum; surgery;
   wound
ID VACUUM-ASSISTED CLOSURE; SURGICAL DEBRIDEMENT; INTERVENTION; THERAPY;
   PATHOPHYSIOLOGY; CYCLOSPORINE; MANAGEMENT; PATHERGY; PG
AB BACKGROUND
   Wound debridement improves healing in a variety of acute and chronic ulcers. However, there is concern that debridement may trigger pathergy and worsen pyoderma gangrenosum (PG).
   OBJECTIVE
   To determine whether published evidence supports conservative wound debridement for PG.
   DATA SOURCES
   The authors reviewed the literature published in MEDLINE through January 2023 using the search germs pyoderma gangrenosum and debridement.
   STUDY SELECTION
   Articles reporting sharp surgical debridement or maggot debridement for PG were included in the review. The authors also searched the reference sections of the reviewed articles for additional reports on debridement for PG.
   DATA EXTRACTION
   Clinical data regarding patient status, procedures performed, and patient outcomes were extracted from the selected articles.
   DATA SYNTHESIS
   There are multiple reports of uncontrolled, active-phase PG wounds worsening after aggressive excisional debridement of viable inflamed tissues. In contrast, there is no evidence indicating that conservative debridement of nonviable necrotic tissue worsens PG wounds, regardless of the disease activity. There are multiple reports of successful debridement and surgical grafting for PG in remission.
   CONCLUSIONS
   There is no evidence in favor of or against using conservative debridement of nonviable necrotic tissue for a PG wound. Therefore, it should not be considered contraindicated, even in the active phase of the disease. Copyright (C) 2023 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Taheri, Arash] JenCare Sr Med Ctr, Atlanta, GA 30310 USA.
   [Mansoori, Parisa] Atlanta Dermatopathol, Atlanta, GA USA.
   [Sharif, Mohammad] Village Podiatry Ctr, Atlanta, GA USA.
RP Taheri, A (通讯作者)，JenCare Sr Med Ctr, Atlanta, GA 30310 USA.
EM arataheri@gmail.com; parisamansoori@hotmail.com; MSharif@vpcenters.com
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NR 54
TC 4
Z9 7
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD FEB
PY 2024
VL 37
IS 2
BP 107
EP 111
DI 10.1097/ASW.0000000000000092
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA FQ1X8
UT WOS:001147234700004
PM 38241454
DA 2026-07-24
ER

PT J
AU Davison, SP
   Clemens, MW
   Armstrong, D
   Newton, ED
   Swartz, W
AF Davison, Steven P.
   Clemens, Mark W.
   Armstrong, Deana
   Newton, Ernest D.
   Swartz, William
TI Sternotomy wounds: Rectus flap versus modified pectoral reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; CONSECUTIVE OPERATIVE
   PROCEDURES; CHEST-WALL RECONSTRUCTION; ABDOMINIS MUSCLE FLAP; STERNAL
   WOUNDS; ANTIBIOTIC IRRIGATION; MEDIASTINAL INFECTION; MYOCUTANEOUS FLAP;
   RISK-FACTORS
AB Background: Infected sternotomy wounds occur in 0.5 to 8.4 percent of open heart operations. They are complex problems, with a mortality rate of 8.1 to 14.8 percent despite flap closure. For closure, the pectoralis major flap has had considerable success. However, in providing coverage to the lower third of the sternum, it may be deficient. Modifications to improve closure have included a rectus flap or an anterior rectus fascia extension to the pectoralis flap.
   Methods: This retrospective study of 130 consecutive sternotomy wounds compares 41 bilateral pectoralis major muscle flaps with a modified anterior rectus fascia extension against 56 rectus abdominis muscle flaps alone in addressing the lower third of the sternum following dehiscence.
   Results: Pectoralis flaps with rectus fascia extension and rectus flaps have similar success, postoperative course, and morbidity and mortality rates. The pectoralis flaps with rectus fascia extensions prevented superior dehiscence, but this modification does not eliminate dehiscence of the distal third of the sternum.
   Conclusions: The rectus muscle alone proved superior in coverage to the inferior sternum. Sternal wounds should be covered preferentially by a pectoralis flap to cover a superior infection and by a rectus flap if the dehiscence is localized to the distal third.
C1 Georgetown Univ, Med Ctr, Div Plast & Reconstruct Surg, Washington, DC 20007 USA.
   Western Penn Hosp, Shadyside Hosp, Pittsburgh, PA 15224 USA.
C3 Georgetown University; West Penn Hospital
RP Clemens, MW (通讯作者)，Georgetown Univ, Med Ctr, Div Plast & Reconstruct Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM markclemens26@yahoo.com
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NR 46
TC 51
Z9 58
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP 15
PY 2007
VL 120
IS 4
BP 929
EP 934
DI 10.1097/01.prs.0000253443.09780.0f
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 208XK
UT WOS:000249352300015
PM 17805121
DA 2026-07-24
ER

PT J
AU Castaño, O
   Pérez-Amodio, S
   Navarro-Requena, C
   Mateos-Timoneda, MA
   Engel, E
AF Castano, Oscar
   Perez-Amodio, Soledad
   Navarro-Requena, Claudia
   Angel Mateos-Timoneda, Miguel
   Engel, Elisabeth
TI Instructive microenvironments in skin wound healing: Biomaterials as
   signal releasing platforms
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Instructive biomaterials; Skin regeneration; Wound healing; Signalling
   release; in situ tissue engineering
ID EPIDERMAL-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; OXIDIZED REGENERATED
   CELLULOSE/COLLAGEN; CERIUM OXIDE NANOPARTICLES; STEM-CELL
   DIFFERENTIATION; DRUG-DELIVERY SYSTEMS; NONVIRAL GENE-THERAPY; DIABETIC
   FOOT ULCERS; PLATELET-RICH PLASMA; IN-VITRO
AB Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signalling molecules that regulate the cellular response and the dynamic remodelling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body's own capacity for regeneration by mobilizing host endogenous stem cells or tissue specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signalling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Castano, Oscar] Univ Barcelona, Elect & Biomed Engn, Marti & Franques 1, E-08028 Barcelona, Spain.
   [Castano, Oscar; Perez-Amodio, Soledad; Navarro-Requena, Claudia; Angel Mateos-Timoneda, Miguel; Engel, Elisabeth] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain.
   [Castano, Oscar; Perez-Amodio, Soledad; Navarro-Requena, Claudia; Angel Mateos-Timoneda, Miguel; Engel, Elisabeth] CIBER BBN, Madrid, Spain.
   [Castano, Oscar] Univ Barcelona, Inst Nanosci & Nanotechnol, Bioelect Unit, Joan 23 S-N, E-08028 Barcelona, Spain.
   [Castano, Oscar] Univ Barcelona, Inst Nanosci & Nanotechnol, Nanobioeneering Lab, Joan 23 S-N, E-08028 Barcelona, Spain.
   [Perez-Amodio, Soledad; Angel Mateos-Timoneda, Miguel; Engel, Elisabeth] Polytech Univ Catalonia UPC, Mat Sci & Met Engn, Eduard Maristany 16, Barcelona 08019, Spain.
C3 University of Barcelona; University of Barcelona; Barcelona Institute of
   Science & Technology; Institut de Bioenginyeria de Catalunya; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERBBN; University of
   Barcelona; University of Barcelona; Universitat Politecnica de Catalunya
RP Engel, E (通讯作者)，Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain.
EM eengel@ibecbarcelona.eu
RI ; /N-3652-2014; Engel, Elisabeth/AAU-6657-2021; Mateos Timoneda, Miguel
   Angel/D-4666-2014; Castano, Oscar/F-6725-2012
OI Navarro Requena, Claudia/0000-0002-0833-5118; Engel,
   Elisabeth/0000-0003-4855-8874; Mateos Timoneda, Miguel
   Angel/0000-0001-7657-1414; Castano, Oscar/0000-0001-9212-784X
FU Spanish Ministry of Economy and Competitiveness [MAT2012-38793,
   MAT2015-68906-R]; Caixalmpulse Programme by Obra Social La Caixa,
   project [C115-00015]; Joint Programme in Healthy Aging Research - Obra
   Social La Caixa and IBEC; EIT-Health, Proof of Concept Programme [EIT
   PoC-2016-SPAIN-03]; CERCA Programme/Generalitat de Catalunya
   [ECO/2405/2015]; Serra Hunter programme [UB-LE-201]; Training University
   Lecturers (FPU) subprogramme from MINECO [FPU2012-05310]
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness through the project [MAT2012-38793] (MINECO) and
   [MAT2015-68906-R] (MINECO/FEDER). The authors also acknowledge the
   Caixalmpulse Programme by Obra Social La Caixa, project [C115-00015];
   the Joint Programme in Healthy Aging Research funded by Obra Social La
   Caixa and IBEC; the EIT-Health, Proof of Concept Programme, project [EIT
   PoC-2016-SPAIN-03]; and the CERCA Programme/Generalitat de Catalunya
   [ECO/2405/2015]. O. Castaiio also acknowledges support from the Serra
   Hunter programme [UB-LE-201] and C. Navarro acknowledges the support of
   the Training University Lecturers (FPU) subprogramme from MINECO
   [FPU2012-05310].
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NR 352
TC 185
Z9 204
U1 4
U2 212
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD APR
PY 2018
VL 129
BP 95
EP 117
DI 10.1016/j.addr.2018.03.012
PN 1
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GM3KU
UT WOS:000438004300008
PM 29627369
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Juhl, AA
   Hody, S
   Videbaek, TS
   Damsgaard, TE
   Nielsen, PH
AF Juhl, Alexander Andersen
   Hody, Sofie
   Videbaek, Tina Senholt
   Damsgaard, Tine Engberg
   Nielsen, Per Hostrup
TI Deep Sternal Wound Infection after Open-Heart Surgery: A 13-Year Single
   Institution Analysis
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE deep sternal wound infection; reconstruction; muscle flap; open-heart
   surgery
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP RECONSTRUCTION; POSTSTERNOTOMY
   MEDIASTINITIS; CARDIAC-SURGERY; COMPLICATIONS; MANAGEMENT; THERAPY
AB Purpose: The present study aimed to compare the clinical outcome for patients with or without muscle flap reconstruction after deep sternal wound infection due to open-heart surgery.
   Methods: The study was a retrospective cohort study, including patients who developed deep sternal wound infection after open-heart surgery in the Western Denmark Region from 1999 to 2011. Journals of included patients were reviewed for clinical data regarding the treatment of their sternal defect. Patients were divided into two groups depending on whether they received a muscle-flap-based sternal reconstruction or traditional rewiring of the sternum.
   Results: A total of 130 patients developed deep sternal wound infection in the study period. In all, 12 patients died before being discharged, leaving a total of 118 patients for analysis. Of these, 50 (42%) patients received muscle flap reconstruction. Muscle flap recipients had significantly longer total hospital stays (p <0.001). However, after receiving muscle flap reconstruction, patients were discharged after a median of 14 days, with 74% not needing additional surgery.
   Conclusion: It is difficult to predict which patients eventually require muscle flap reconstruction after deep sternal wound infection. Although patients receiving muscle flap reconstructions have longer hospital stays, they are quickly discharged after the reconstruction.
C1 [Juhl, Alexander Andersen; Hody, Sofie; Videbaek, Tina Senholt; Damsgaard, Tine Engberg] Aarhus Univ Hosp, Dept Plast & Breast Surg, Plast Surg Res Unit, 44 Norrebrogade, DK-8000 Aarhus C, Denmark.
   [Nielsen, Per Hostrup] Aarhus Univ Hosp, Dept Cardiothorac Surg, Aarhus, Denmark.
C3 Aarhus University; Aarhus University
RP Juhl, AA (通讯作者)，Aarhus Univ Hosp, Dept Plast & Breast Surg, Plast Surg Res Unit, 44 Norrebrogade, DK-8000 Aarhus C, Denmark.
EM alexander@clin.au.dk
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NR 23
TC 26
Z9 32
U1 1
U2 1
PU MEDICAL TRIBUNE INC
PI TOKYO
PA ED COMM ANNALS THORACIC CARDIOVASCULAR SURG, 2-1-30 KUDAN MINAMI,
   CHIYODA-KU, TOKYO, 102-0074, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2017
VL 23
IS 2
BP 76
EP 82
DI 10.5761/atcs.oa.16-00196
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA EU4MA
UT WOS:000401002500003
PM 28163297
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Orseck, MJ
   Trujillo, MG Jr
   Ritter, EF
AF Orseck, Michael J.
   Trujillo, Manny G., Jr.
   Ritter, Edmond F.
TI Screw Fixation of Dermal Regeneration Template for Scalp Reconstruction
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE dermal regeneration template; Integra; scalp; scalp reconstruction;
   screw fixation; fixation
ID DEFECTS; INTEGRA; SKIN
AB Despite many advances in reconstructive techniques, the full-thickness scalp defect remains a difficult problem for the reconstructive surgeon. Patient and disease-specific factors occasionally make reconstruction with a dermal regeneration template (DRT) an attractive option when other methods are less advised. Although the applicability of dermal regeneration templates has been well elucidated, the method of DRT immobilization has not been standardized. Given the difficulty of adherence and subsequent infiltration of host cells into the DRT from the underlying bone due to seroma, hematoma, or shearing forces, we propose a screw and bolster system for DRT immobilization. We present a series of 13 patients with full-thickness scalp loss who underwent reconstruction with DRT and a subsequent split-thickness skin graft. All 13 patients were treated with the screw-bolster method of DRT fixation before a vacuum-assisted closure dressing. The average surface area of the defect was 96 cm(2). The mean time interval between the application of DRT and skin graft was 28 days. At a mean of 9-month follow-up, all patients achieved a well-vascularized neo-dermis, and progressed to complete, stable wound healing following application of a split-thickness skin graft. We propose that a screw-bolster system of fixation is a safe and effective method of immobilizing DRT in full-thickness scalp defects.
C1 [Trujillo, Manny G., Jr.] Spartanburg Reg Med Ctr, Dept Surg Educ, Spartanburg, SC 29303 USA.
   [Orseck, Michael J.] Spartanburg Reg Med Ctr, Div Plast Surg, Spartanburg, SC 29303 USA.
   [Ritter, Edmond F.] Med Coll Georgia, Div Plast Surg, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Trujillo, MG Jr (通讯作者)，Spartanburg Reg Med Ctr, Dept Surg Educ, 101 E Wood St, Spartanburg, SC 29303 USA.
EM mtrujillomd@gmail.com
CR [Anonymous], PLAST RECONSTR SURG
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NR 7
TC 11
Z9 12
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2012
VL 68
IS 5
BP 457
EP 460
DI 10.1097/SAP.0b013e318243390b
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 930UD
UT WOS:000303166200011
PM 22531400
OA hybrid
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Gesslein, B
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Gesslein, Bodil
   Ingemansson, Richard
TI Topical negative pressure effects on coronary blood flow in a sternal
   wound model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Coronary blood flow; Poststernotomy mediastinitis; Topical negative
   pressure (TNP)
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR;
   PERISTERNAL THORACIC WALL; ANGIOGENIC GENE-THERAPY; BYPASS
   GRAFT-SURGERY; RISK-FACTORS; CARDIAC-SURGERY; ARTERY-DISEASE;
   SHEAR-STRESS
AB Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P < 0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P < 0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
   [Malmsjo, Malin; Gesslein, Bodil] Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
FU Anders Otto Sward's Foundation/Ulrika Eklund's Foundation; Anna Lisa and
   Sven Eric Lundgren's Foundation for medical research; Angstromke Wiberg
   Foundation; M. Bergvall Foundation; Swedish Medical Association; Royal
   Physiographic Society in Lund; Swedish Medical Research Council;
   Crafoord Foundation; Swedish Heart-Lung Foundation; Swedish Government;
   Swedish Hypertension Society
FX We would like to thank Johan Ingemansson (Statistical Solutions IP) for
   his expert contribution to the statistic analyses. This study was
   supported by Anders Otto Sward's Foundation/Ulrika Eklund's Foundation,
   Anna Lisa and Sven Eric Lundgren's Foundation for medical research, the
   angstrom ke Wiberg Foundation, the M. Bergvall Foundation, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the
   Swedish Medical Research Council, the Crafoord Foundation, the Swedish
   Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research and the Swedish Hypertension Society.
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NR 43
TC 14
Z9 15
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2008
VL 5
IS 4
BP 503
EP 509
DI 10.1111/j.1742-481X.2008.00429.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BD
UT WOS:000207844200004
PM 19006573
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Hodge, JG
   Zamierowski, DS
   Robinson, JL
   Mellott, AJ
AF Hodge, Jacob G.
   Zamierowski, David S.
   Robinson, Jennifer L.
   Mellott, Adam J.
TI Evaluating polymeric biomaterials to improve next generation wound
   dressing design
SO BIOMATERIALS RESEARCH
LA English
DT Review
DE Biomaterials; Polymers; Tissue Engineering; Wound Dressings; Wound
   Healing
ID VACUUM-ASSISTED CLOSURE; DRUG-DELIVERY; STEM-CELL; ANTIMICROBIAL
   HYDROGELS; RADIATION DERMATITIS; INJECTABLE HYDROGELS; SURFACE
   MODIFICATION; MECHANICAL FORCES; SKIN SUBSTITUTES; MOLECULAR-BASIS
AB Wound healing is a dynamic series of interconnected events with the ultimate goal of promoting neotissue formation and restoration of anatomical function. Yet, the complexity of wound healing can often result in development of complex, chronic wounds, which currently results in a significant strain and burden to our healthcare system. The advancement of new and effective wound care therapies remains a critical issue, with the current therapeutic modalities often remaining inadequate. Notably, the field of tissue engineering has grown significantly in the last several years, in part, due to the diverse properties and applications of polymeric biomaterials. The interdisciplinary cohesion of the chemical, biological, physical, and material sciences is pertinent to advancing our current understanding of biomaterials and generating new wound care modalities. However, there is still room for closing the gap between the clinical and material science realms in order to more effectively develop novel wound care therapies that aid in the treatment of complex wounds. Thus, in this review, we discuss key material science principles in the context of polymeric biomaterials, provide a clinical breadth to discuss how these properties affect wound dressing design, and the role of polymeric biomaterials in the innovation and design of the next generation of wound dressings.
C1 [Hodge, Jacob G.] Univ Kansas, Bioengn Grad Program, Lawrence, KS 66045 USA.
   [Hodge, Jacob G.; Zamierowski, David S.; Mellott, Adam J.] Univ Kansas, Med Ctr, Dept Plast Surg, Kansas City, KS 66103 USA.
   [Robinson, Jennifer L.] Univ Kansas, Dept Chem & Petr Engn, Mail Stop 3051,3901 Rainbow Blvd, Lawrence, KS 66160 USA.
C3 University of Kansas; University of Kansas; University of Kansas Medical
   Center; University of Kansas
RP Mellott, AJ (通讯作者)，Univ Kansas, Med Ctr, Dept Plast Surg, Kansas City, KS 66103 USA.
EM amellott@kumc.edu
RI Mellott, AJ/HOF-9580-2023
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NR 278
TC 75
Z9 85
U1 4
U2 52
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1226-4601
EI 2055-7124
J9 BIOMATER RES
JI Biomater. Res.
PD OCT 1
PY 2022
VL 26
IS 1
AR 50
DI 10.1186/s40824-022-00291-5
PG 39
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 5A0DE
UT WOS:000862566600002
PM 36183134
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhang, KF
   Shi, CX
   Chen, SY
   Wei, W
AF Zhang, Ke-Fan
   Shi, Chuan-Xin
   Chen, Si-Yu
   Wei, Wei
TI Progress in Multidisciplinary Treatment of Fournier's Gangrene
SO INFECTION AND DRUG RESISTANCE
LA English
DT Review
DE Fournier?s gangrene; necrotizing fasciitis; lethal infection; surgical
   debridement; multidisciplinary cooperation
ID SOFT-TISSUE INFECTIONS; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; NECROTIZING FASCIITIS; SURVIVING SEPSIS; SCORING SYSTEM;
   MANAGEMENT; DIAGNOSIS; MORTALITY; OUTCOMES
AB Fournier's gangrene (FG) is a life-threatening and special form of necrotizing fasciitis, characterized by occult onset, rapid progress and high mortality, occurring mainly in men over 50 years of age. Risk factors of FG include diabetes, HIV infection, chronic alcoholism and other immunosuppressive state. FG was previously considered as an idiopathic disease, but in fact, three quarters of the infections originated from the skin, urethra and gastrointestinal tract. Initial symptoms of FG are often inconsistent with severity and can progress promptly to fatal infection. Although the treatment measures of FG have been improved in recent years, the mortality does not seem to have decreased significantly and remains at 20% - 30%. The time to identify FG and the waiting period before surgical debridement are directly related to the prognosis. Therefore, in addition to the combination of intensive fluid resuscitation and broad-spectrum antibiotics, treatment of FG should particularly emphasize the importance of early surgical debridement assisted with fecal diversion and skin reconstruction when necessary. This paper is to briefly summarize the progress in the definition, epidemiology, clinical manifestations, diagnosis, treatment and prognosis of Fournier's gangrene in recent years, more importantly, illustrates the importance of multidisciplinary cooperation in the management of FG.
C1 [Zhang, Ke-Fan; Shi, Chuan-Xin; Wei, Wei] Nanjing Med Univ, Affiliated Hosp 2, Dept Gen Surg, Nanjing, Peoples R China.
   [Chen, Si-Yu] Nanjing Med Univ, Nanjing Hosp 1, Dept Cardiol, Nanjing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Wei, W (通讯作者)，Nanjing Med Univ, Affiliated Hosp 2, Dept Gen Surg, Nanjing, Peoples R China.
EM kevinwei@njmu.edu.cn
RI ; Shi, Chuanxin/GXH-0616-2022
OI WEI, WEI/0000-0002-6734-5623; chensiyu, chensiyu/0000-0002-7423-012X; 
FU 789 Excellent Talents Training Program of The Second Affiliated Hospital
   of Nanjing Medical University;  [789ZYRC202070210]
FX Funding This project is funded by the 789 Excellent Talents Training
   Program of The Second Affiliated Hospital of Nanjing Medical University
   (Grant number: 789ZYRC202070210) .
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NR 125
TC 19
Z9 37
U1 1
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2022
VL 15
BP 6869
EP 6880
DI 10.2147/IDR.S390008
PG 12
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 6P7KA
UT WOS:000891104500001
PM 36465810
OA Green Published, gold
DA 2026-07-24
ER

PT J
AU Colen, DL
   Colen, LB
   Levin, LS
   Kovach, SJ
AF Colen, David L.
   Colen, Lawrence B.
   Levin, L. Scott
   Kovach, Stephen J.
TI Godina's Principles in the Twenty-First Century and the Evolution of
   Lower Extremity Trauma Reconstruction
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article; Proceedings Paper
CT 9th Congress of the World-Society-for-Reconstructive-Microsurgery (WSRM)
CY JUN 14-17, 2017
CL Seoul, SOUTH KOREA
SP World Soc Reconstruct Microsurgery
DE Godina; lower extremity trauma; free flap; microsurgery; limb salvage
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; ANTEROLATERAL THIGH
   FLAPS; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE DEFECTS; FASCIOCUTANEOUS
   FLAPS; CHRONIC OSTEOMYELITIS; MUSCLE FLAP; MICROVASCULAR SURGERY;
   BACTERIAL INOCULATION
AB Background February of 2016 marked 30 years since the passing of Marko Godina, a pioneer and prodigy in the field of reconstructive microsurgery. Most noteworthy among his many contributions was his method of radical debridement of contaminated compound fractures followed by early free tissue transfer for wound closure. In the last three decades, the landscape of reconstructive surgery has undergone significant transformation owing to advances in reconstructive techniques and wound care technology, as well as new data.
   Methods Dr. Godina's work and legacy are reviewed, compared and contrasted with new and evolving data regarding lower extremity trauma reconstruction.
   Results Advancements in technique and technology have greatly molded lower extremtiy reconstruction over the past thirty years. Nonetheless, Dr. Godina's principles of timely care and early vascularized soft tissue coverage have withstood the test of time.
   Conclusion Marko Godina's contribution to reconstructive microsurgery cannot be overstated and his groundbreaking work continues to serve as the foundation of lower extremity trauma reconstruction. Three decades after his seminal work, we honor Dr. Godina's legacy and explore how his principles have endured, evolved, or been replaced.
C1 [Colen, David L.; Levin, L. Scott; Kovach, Stephen J.] Univ Penn Hlth Syst, Div Plast Surg, Dept Surg, Philadelphia, PA USA.
   [Colen, Lawrence B.] Eastern Virginia Med Sch, Dept Surg, Div Plast Surg, Norfolk, VA 23501 USA.
   [Levin, L. Scott; Kovach, Stephen J.] Univ Penn Hlth Syst, Dept Orthopaed Surg, Philadelphia, PA USA.
C3 University of Pennsylvania; Eastern Virginia Medical School; University
   of Pennsylvania
RP Kovach, SJ (通讯作者)，Perelman Ctr Adv Med, South Pavil Extens,14th Floor,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM Stephen.Kovach@uphs.upenn.edu
RI ; Colen, Lawrence/AAJ-4443-2020
OI Colen, David/0009-0001-4760-5002; 
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NR 58
TC 30
Z9 36
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD OCT
PY 2018
VL 34
IS 8
BP 563
EP 571
DI 10.1055/s-0037-1607348
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GT5ZQ
UT WOS:000444590100005
PM 29121685
DA 2026-07-24
ER

PT J
AU Rau, O
   Reiher, F
   Tautenhahn, J
   Allhoff, EP
AF Rau, O
   Reiher, F
   Tautenhahn, J
   Allhoff, EP
TI VAC® (Vacuum Assisted Closure™) therapy as a treatment option in
   complications following lymphadenectomy in patients with penile cancer
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE penile cancer; lymphadenectomy; secondary wound healing; VAC (R) therapy
ID SQUAMOUS-CELL-CARCINOMA; HUMAN-PAPILLOMAVIRUS; GROIN DISSECTION;
   MANAGEMENT
AB Introduction: Penile cancer is a rare tumor entity. Primary therapy consists of tumor excision (laser therapy, circumcision, partial or complete penectomy). Therapy of advanced or metastasized penile cancer is still challenging due to high morbidity with postoperative lymph edema, fistula, wound infection and resulting secondary wound healing. Methods: In this series we retrospectively investigated clinical and diagnostic data from 28 patients (1995-2005) with penile cancer regarding their follow-up, especially in respect to morbidity after lymphadenectomy and the resulting therapy. We evaluated the efficacy of V.A.C.(R) therapy as an alternative in this setting regarding costs and duration of hospital stay. Results: 11/28 pats. underwent lymphadenectomy(LA) because of tumor stage or suspicious lymph node status. Eight of those pats. developed complications, as there were: lymph edema, and/or secondary wound healing with fistula. 4/8 pats. were treated with V.A.C.(R) therapy. In this group a significant advantage regarding cost and time of hospitalization was observed. Discussion: Despite higher primary introduction costs an early V.A.C.(R) therapy in patients with secondary wound healing and lymph obstruction is advisable and resulted in a shortened hospitalization and reduced overall costs per patient.
C1 Univ Klinikum Magdeburg AoR, Urol Univ Klin, D-39120 Magdeburg, Germany.
   Univ Klinikum Magdeburg AoR, Zentrum Chirurg, D-39120 Magdeburg, Germany.
C3 University Hospital Magdeburg; University Hospital Magdeburg
RP Rau, O (通讯作者)，Univ Klinikum Magdeburg AoR, Urol Univ Klin, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM olrik.rau@medizin.uni-magdeburg.de
CR Bezerra ALR, 2001, CANCER, V91, P2315, DOI 10.1002/1097-0142(20010615)91:12<2315::AID-CNCR1263>3.0.CO;2-C
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NR 20
TC 4
Z9 4
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S153
EP S156
DI 10.1055/s-2006-921486
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100036
PM 16575669
DA 2026-07-24
ER

PT J
AU Qu, WR
   Pan, JB
   Jin, HJ
   Wang, XJ
   Tian, H
AF Qu, Wenrui
   Pan, Junbo
   Jin, Hongjuan
   Wang, Xuejie
   Tian, Heng
TI Acute compartment syndrome secondary to anterolateral thigh flap
   harvesting in a pediatric patient A case report
SO MEDICINE
LA English
DT Article
DE anterolateral thigh flap; compartment syndrome; complications
ID DONOR-SITE COMPLICATIONS; RECONSTRUCTION; DEFECTS
AB Introduction: The anterolateral thigh (ALT) flap is the most popularly used flap for major soft tissue reconstruction. Although it is widely used, acute compartment syndrome (ACS) in pediatric patients has rarely been reported in the literature. We herein reported a case of ACS in a 6-year-old girl after ALT flap harvest with direct closure of the donor site. Patient concerns: A 6-year-old girl was admitted to the Second Hospital of Jilin University with crush injury on the palmar aspect of the right hand and wrist. Diagnosis: Examination showed soft tissue defect of the hand and wrist, damage on the thenar muscles, lightly crushed flexor tendons, crushed median nerve, and ulnar artery thrombosis. Interventions: The defect was closed with an ipsilateral ALT flap measuring 9 cm in length by 6 cm in width. Outcomes: After debridement was performed 3 times, the majority of the rectus femoris and lateral femoris were removed. Secondary closure by skin grafting was performed 2 weeks later. Three days after the procedure, necrotic tissues were noted on the edges of the wound. The diagnosis of ACS of the right was made. A second exploration was decided, and an extensive anterior compartment fasciotomy was performed. After 6 weeks of vacuum sealing drainage therapy, the defect was closed with a free latissimus dorsi musculocutaneous flap. At 4 months of follow-up, the right thigh wound had healed. At 6 months of follow-up, quadriceps muscle weakness remained. At 1 year of follow-up, the patient's mobility had been significantly improved, but diminished sensation remained on the lateral aspect of the thigh. Conclusion: ACS can occur after ALT flap harvesting in pediatric patients and should be recognized as early as possible to avoid devastating complications.
C1 [Qu, Wenrui; Wang, Xuejie; Tian, Heng] Jilin Univ, Hosp 2, Dept Hand Surg, 218 Ziqiang St, Changchun, Jilin, Peoples R China.
   [Pan, Junbo] Yanzhou Univ, Affiliated Hosp, Dept Hand & Foot Surg, Yanzhou, Jiangsu, Peoples R China.
   [Jin, Hongjuan] Jilin Univ, Hosp 1, Dept Plast & Reconstruct Surg, Changchun, Peoples R China.
C3 Jilin University; Yangzhou University; Jilin University
RP Tian, H (通讯作者)，Jilin Univ, Hosp 2, Hand Surg, 218 Ziqiang St,2-11 Bldg,Room 102, Changhun 130000, Jl, Peoples R China.
EM 272033479@qq.com
RI Qu, Wenrui/AAL-9639-2020
OI Qu, Wenrui/0000-0002-0178-3698
CR Acar MA, 2015, J RECONSTR MICROSURG, V31, P225, DOI 10.1055/s-0034-1395888
   Addison PD, 2008, ANN PLAS SURG, V60, P635, DOI 10.1097/SAP.0b013e3181453b7a
   Agostini T, 2013, J CRANIO MAXILL SURG, V41, P15, DOI 10.1016/j.jcms.2012.05.003
   Broom A, 2016, J CHILD ORTHOP, V10, P453, DOI 10.1007/s11832-016-0766-0
   Collins J, 2012, CAN J PLAST SURG, V20, P17, DOI 10.1177/229255031202000103
   Driscoll EBS, 2016, LOCAL REG ANESTH, V9, P65, DOI 10.2147/LRA.S109659
   Flynn JM, 2011, J BONE JOINT SURG AM, V93A, P937, DOI 10.2106/JBJS.J.00285
   Fodor L, 2011, INT J ORAL MAX SURG, V40, P443, DOI 10.1016/j.ijom.2010.10.021
   Gharb BB, 2011, ANN PLAS SURG, V66, P143, DOI 10.1097/SAP.0b013e3181e35e38
   Kerrary S, 2011, J CRANIO MAXILL SURG, V39, P206, DOI 10.1016/j.jcms.2010.03.012
   Kimata Y, 2000, PLAST RECONSTR SURG, V106, P584, DOI 10.1097/00006534-200009030-00009
   Maruccia M, 2017, J PLAST RECONSTR AES, V70, P972, DOI 10.1016/j.bjps.2017.03.007
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   Yildirim S, 2008, MICROSURG, V28, P99, DOI 10.1002/micr.20458
NR 14
TC 0
Z9 0
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL 10
PY 2020
VL 99
IS 28
AR 21216
DI 10.1097/MD.0000000000021216
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MX1UD
UT WOS:000557511400122
PM 32664172
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhu, ZH
   Zhao, JJ
   Zuo, ZC
   Zhou, KL
AF Zhu, Zhenhua
   Zhao, Jiaju
   Zuo, Zhicheng
   Zhou, Kailong
TI Repair of tophus wound of the heel with sural nerve nutrition flap with
   peroneal artery perforating branch: a retrospective study
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Peroneal artery perforator; sural nerve flap; tophus; wounds
AB Background: This study was to investigate the clinical effect of a sural nerve nutrition flap with peroneal artery perforator for repairing tophus wound of the heel.
   Methods: Over a 5-year period, 7 elderly male patients with tophus ulceration of the heel were admitted with exposed Achilles' tendon, and a chronic unhealed wound. Debridement, expansion and vacuum sealing drainage (VSD) lavage were performed initially, with simultaneous uric acid-lowering treatment. A 4x6-8x10 cm sural nerve nutrition flap with peroneal artery perforator was the secondary repair after further debridement of the wound. Preoperative Doppler ultrasound located the penetrating point of the peroneal artery perforator as the rotation point of the flap, and the line between the midpoint of the Achilles' tendon and the lateral malleolus and the midpoint of the popliteal fossa 5 degrees above the front of Achilles' tendon was the axis. The patients were treated postoperatively with anti-inflammatory, anticoagulant and spasmolytic drugs and other rehydration therapy, and allopurinol was continued to control uric acid. The blood supply and temperature of the flap and wound healing were monitored.
   Results: All 7 flaps survived completely after operation, with 1 case of postoperative wound discharge that finally healed after dressing change and 1 case of skin flap redness and swelling, which improved after strengthening anti-infection treatment. All 7 patients were followed up for 6-12 months (average 10 months). The skin flaps were soft in texture, with good color and appearance, and no recurrence of ulceration. The dorsal extension and plantar flexion of the ankle joint were good, and function was satisfactory.
   Conclusions: The sural nerve nutrition flap with peroneal artery perforator has double blood supply, strong anti-infective ability, relatively fast tissue healing process, simple operation and high survival rate, making it ideal for repairing tophus wounds of the heel.
C1 [Zhu, Zhenhua; Zhao, Jiaju; Zuo, Zhicheng; Zhou, Kailong] Soochow Univ, Affiliated Hosp 2, Dept Hand & Foot Surg, Suzhou 215004, Peoples R China.
C3 Soochow University - China
RP Zhou, KL (通讯作者)，Soochow Univ, Affiliated Hosp 2, Dept Hand & Foot Surg, Suzhou 215004, Peoples R China.
EM zhoukailong1982@126.com
RI zhu, zh/KFB-9018-2024
FU Program of Key Research and Development of Jiangsu Province [BE2018656];
   Key Medical Discipline in Suzhou [Szxk201802]; Training Project of
   "National Tutor System" for Young Health Talents in Suzhou; Key
   laboratory of Hand Function reconstruction, Ministry of Health
   [17DZ2270500]
FX This research received financial support from the Program of Key
   Research and Development of Jiangsu Province (grant No. BE2018656), Key
   Medical Discipline in Suzhou (grant No. Szxk201802), Training Project of
   "National Tutor System" for Young Health Talents in Suzhou and the Key
   laboratory of Hand Function reconstruction, Ministry of Health (grant
   No. 17DZ2270500).
CR Chen J, 2018, CHIN J MICROSURG, V41, P487
   [池征璘 Chi Zhenglin], 2020, [中华显微外科杂志, Chinese Journal of Microsurgery], V43, P238
   [冯少清 Feng Shaoqing], 2016, [中华显微外科杂志, Chinese Journal of Microsurgery], V39, P26, DOI 10.3760/cma.j.issn.1001-2036.2016.01.008
   HASEGAWA M, 1994, PLAST RECONSTR SURG, V93, P1012, DOI 10.1097/00006534-199404001-00016
   Hui M, 2017, RHEUMATOLOGY, V56, P1056, DOI 10.1093/rheumatology/kex150
   Kuo CF, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0522-8
   Li C., 2018, CHIN J ALLERGY CLIN, V12, P25
   Liang QC., 2013, CHIN J CLIN ONCOL, V7, P205
   Liu JH, 2018, CHIN J MICROSURG, V41, P266
   MASQUELET AC, 1992, PLAST RECONSTR SURG, V89, P1115, DOI 10.1097/00006534-199206000-00018
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   Yao Shuangquan, 2006, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V20, P881
   尹朝东, 2019, [中华显微外科杂志, Chinese Journal of Microsurgery], V42, P173
   Zhong SZ., 1999, CHIN J MICROSURG, V22, P37
NR 14
TC 3
Z9 5
U1 0
U2 14
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD OCT
PY 2021
VL 10
IS 10
BP 11067
EP 11073
DI 10.21037/apm-21-2809
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA WS1UF
UT WOS:000714973900003
PM 34763468
OA gold
DA 2026-07-24
ER

PT J
AU Wang, YH
   Hao, DJ
   Qian, LX
   He, X
   Meng, YB
   Wang, B
AF Wang, Yuhang
   Hao, Dingjun
   Qian, Lixiong
   He, Xin
   Meng, Yibin
   Wang, Biao
TI Esophageal perforation following pedicle screw placement for the
   treatment of upper thoracic spinal tuberculosis: a case report and
   review of the literature
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Review
DE Upper thoracic spinal tuberculosis; Esophageal perforation; Esophageal
   fistula; Pedicle screw; Infection
ID ADOLESCENT IDIOPATHIC SCOLIOSIS; ACCURACY; COMPLICATIONS; MANAGEMENT;
   SURGERY
AB BackgroundThe technique of posterior pedicle screw fixation has already been widely applied in the treatment of upper thoracic spinal tuberculosis. However, lesions of tuberculosis directly invade the vertebrae and surrounding soft tissues, which increases the risk of esophageal perforation induced by the posterior pedicle screw placement. Herein, we report the first case of esophageal perforation following pedicle screw placement in the upper thoracic spinal tuberculosis, and describe the underlying causes, as well as the treatment and prognosis.Case presentationA 48-year-old female patient with upper thoracic spinal tuberculosis presented sputum-like secretions from the wound after she was treated with one-stage operation through the posterolateral approach. Endoscopy was immediately conducted, which confirmed that the patient complicated with postoperative esophageal perforation caused by screws. CT scan showed that the right screw perforated the anterior cortex of the vertebrae and the esophagus at the T4 level. Fortunately, mediastinal infection was not observed. The T4 screw was removed, Vacuum Sealing Drainage (VSD) was performed, and jejunum catheterization was used for enteral nutrition. After continuous treatment with sensitive antibiotics for 2.5months and 5 times of VSD aspiration, the infected wound recovered gradually. With 18-month follow-up, the esophagus healed well, without symptoms of dysphagia and stomach discomfort, and CT scan showed that T2-4 had complete osseous fusion without sequestrum.ConclusionTuberculosis increases the risk of postoperative esophageal perforation in a certain degree for patients with upper thoracic tuberculosis. The damages to esophagus during the operation should be prevented. The screws with the length no more than 30mm should be selected. Moreover, close monitoring after operation should be conducted to help the early identification, diagnosis and treatment, which could help preventing the adverse effects induced by the delayed diagnosis and treatment of esophageal perforation.
C1 [Wang, Yuhang; Hao, Dingjun; Qian, Lixiong; He, Xin; Meng, Yibin; Wang, Biao] Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Coll Med, 76 Nanguo Rd, Xian 710054, Shaanxi, Peoples R China.
   [Wang, Yuhang] Xian Med Univ, 74 Hanguang North Rd, Xian 710054, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Medical University
RP Wang, B (通讯作者)，Xi An Jiao Tong Univ, Honghui Hosp, Dept Spine Surg, Coll Med, 76 Nanguo Rd, Xian 710054, Shaanxi, Peoples R China.
EM wangbiaowb1987@126.com
OI Wang, Biao/0000-0001-6631-9127
FU Medical Research Project of Xi'an Science and Technology Bureau
   [201805096YX4SF30-4]
FX This work was supported by the Medical Research Project of Xi'an Science
   and Technology Bureau (201805096YX4SF30-4). Fundings include the cost of
   collecting the fellow-up data and publication fee.
CR Abbas G, 2009, SURGERY, V146, P749, DOI 10.1016/j.surg.2009.06.058
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NR 25
TC 4
Z9 5
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD DEC 18
PY 2020
VL 21
IS 1
AR 756
DI 10.1186/s12891-020-03783-4
PG 6
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA OZ7TH
UT WOS:000595123300001
PM 33208114
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, YX
   Chen, N
AF Liu, Yuxin
   Chen, Na
TI Clinical evaluation of continuous irrigation with Bikerui combined with
   negative pressure closed drainage and platelet-rich plasma technique for
   treatment of stage III-IV pressure ulcer
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE Bikerui disinfectant; negative pressure drainage; platelet-rich plasma;
   pressure ulcer; scar recovery
ID PREVENTION
AB Introduction: As a catastrophic complication of bedridden and elderly patients, pressure ulcer usually continuously affects patients' health and quality of life, so the daily care of wounds is attached great importance in clinic.
   Aim: This work investigated the effect of Bikerui disinfectant + vacuum sealing drainage (VSD) + platelet -rich plasma (PRP) therapy on patients with stage III similar to IV pressure sore.
   Material and methods: In this work, 110 patients with pressure ulcer (PU) treated in our hospital were enrolled and were randomly divided into an experimental group (Exp group) and a control group (Ctrl group) by a blind selection method, with 55 cases in each group. Patients in the Ctrl group received surgical debridement + VSD for treatment, while those in the Exp group were treated with Bikerui disinfectant + VSD + PRP. Inflammatory response (IR) score, PU healing (PUH) score, healing time, dressing change frequency (DCF), dressing interval time (DIT), and scar recovery (SR) score of patients in different groups were compared.
   Results: The results revealed that the positive rate of bacterial culture in wound secretions in the Exp group was greatly lower than that in the Ctrl group 1 or 2 weeks after treatment (p < 0.05). The IR score in the Exp group was much lower at week 1 and 2 after treatment (p < 0.05). The total effective rate (TER) in the Exp group was obviously higher than that in the Ctrl group (94.55% vs. 76.36%).
   Conclusions: The results suggested that Bikerui disinfectant + VSD + PRP therapy could effectively improve the inflammatory degree of PU patients, promote the wound repair and scar recovery of patients, and greatly improve the clinical efficacy of PU patients.
C1 [Liu, Yuxin] Xingtai Med Coll, Affiliated Hosp 2, Dept Tradit Chinese Med, Xingtai, Hebei, Peoples R China.
   [Chen, Na] Xingtai Med Coll, Affiliated Hosp 2, Dept Neurol, Xingtai, Hebei, Peoples R China.
C3 Xingtai Medical College; Xingtai Medical College
RP Liu, YX (通讯作者)，Xingtai Med Coll, Affiliated Hosp 2, Dept Tradit Chinese Med, Xingtai, Hebei, Peoples R China.
EM luzhaolan886459155@163.com
FU Xingtai Science and Technology Program, Clinical study on the treatment
   of stage III [2017ZC039]
FX The research was supported by the Xingtai Science and Technology
   Program, Clinical study on the treatment of stage III and IV pressure
   sores with continuous washing of Baikerui disinfectant combined with VSD
   and PRP technology (No. 2017ZC039) . Yuxin Liu and Na Chen contributed
   equally to this work as co-first author.
CR Al-Azzouny MA, 2016, CELL MOL BIOL, V62, P10, DOI 10.14715/cmb/2016.62.3.3
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NR 25
TC 2
Z9 2
U1 1
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1642-395X
EI 2299-0046
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2024
VL 41
IS 2
BP 181
EP 188
DI 10.5114/ada.2024.138675
PG 8
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA RT2G2
UT WOS:001229839700017
PM 38784931
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yuan, YS
   Ding, XF
   Jing, ZW
   Lu, H
   Yang, K
   Wang, YL
   Xu, HL
AF Yuan, Yusong
   Ding, Xiaofang
   Jing, Zhengwei
   Lu, Hao
   Yang, Kun
   Wang, Yuanli
   Xu, Hailin
TI Modified tibial transverse transport technique for the treatment of
   ischemic diabetic foot ulcer in patients with type 2 diabetes
SO JOURNAL OF ORTHOPAEDIC TRANSLATION
LA English
DT Article
DE Tibia transverse transport; Ischemic diabetic foot ulcer; Type 2
   diabetes; Cohort study
ID PERIPHERAL ARTERY-DISEASE; DEBRIDEMENT; MANAGEMENT; AMPUTATION; NETWORK
AB Background: Ischemic diabetic foot ulcer is one of the terminal complications of diabetes. The high amputation rate, recurrence rate, and treatment cost have caused a huge burden on patients and society. This study designed the modified tibial transverse transport (mTTT) technology to treat diabetic ischemic diabetic foot ulcers in patients with type 2 diabetes and investigated the effectiveness and safety of this technique.
   Methods: This was a retrospective analysis of patients with type 2 diabetes and ischemic diabetic foot ulcers at two hospitals during January 2016-October 2019. These patients underwent mTTT surgery combined with wound debridement and vacuum sealing drainage negative pressure drainage treatment. In-hospital follow-up was performed at 1 month after the operation, while outpatient follow-up was performed at 3, 6, and 12 months after the operation. The ulcer healing time, recurrence rate, major amputation rate, and complications were analysed.
   Results: A total of 201 patients were enrolled in this study, including 107 males and 94 females (mean age: 68.3 +/- 7.1 years). The wounds of all patients healed completely (mean healing time: 4.6 +/- 1.6 months). There was no occurrence of major amputation, recurrence, and treatment-related complications in the patients.
   Conclusion: mTTT can effectively and safely treat ischemic diabetic foot ulcers in patients with type 2 diabetes. This technology is an important part of the ischemic diabetic foot ulcer treatment system and warrants further research.
   The Translational Potential of this Article: This study introduced a new method to treat the ischemic diabetic foot ulcer which was called modified tibial transverse transport. The promising outcomes of patients indicated that this surgical method had great potential for clinical application and was worthy of further clinical research with high evidence level.
C1 [Yuan, Yusong; Lu, Hao; Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Dept Trauma & Orthopaed, Beijing, Peoples R China.
   [Yuan, Yusong; Lu, Hao; Xu, Hailin] Peking Univ, Peking Univ Peoples Hosp, Diabet Foot Treatment Ctr, Beijing, Peoples R China.
   [Yuan, Yusong] Peking Univ, Minist Educ, Key Lab Trauma & Neural Regenerat, Beijing, Peoples R China.
   [Ding, Xiaofang; Yang, Kun; Wang, Yuanli] Beijing Longfu Hosp, 18th Art Museum East St, Beijing, Peoples R China.
   [Jing, Zhengwei] Peking Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing, Peoples R China.
   [Yuan, Yusong; Lu, Hao; Xu, Hailin] Natl Ctr Trauma Med, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University; Peking
   University
RP Wang, YL (通讯作者)，Beijing Longfu Hosp, 18th Art Museum East St, Beijing, Peoples R China.; Xu, HL (通讯作者)，Peking Univ, Peking Univ Peoples Hosp, Diabet Foot Treatment Ctr, Dept Trauma & Orthopaed, 11th Xizhimen South St, Beijing, Peoples R China.
EM 13797757@qq.com; xuhailinfa@163.com
OI Xu, Hailin/0000-0003-1829-3852
FU Capital's Funds for Health Improvement and Research [2020-2-4086];
   Beijing Municipal Science and Technology Project [Z181100001718159];
   Pilot project on clinical collaboration of major and difficult diseases
   of Chinese and Western medicine [201803190106]; Health Science and
   Technology Project of Beijing Dongcheng District Health Commission
   [[2018]-13]; Key Laboratory of Trauma and Neural Regeneration (Peking
   University), Ministry of Education [BMU2019XY007-01]; Ministry of
   Education Innovation Program of China [IRT_16R01]
FX This study was supported by the Capital's Funds for Health Improvement
   and Research (Grant No. 202024086) ; Beijing Municipal Science and
   Technology Project (Grant No. Z181100001718159) ; Pilot project on
   clinical collaboration of major and difficult diseases of Chinese and
   Western medicine (Grant No. 201803190106) ; Health Science and
   Technology Project of Beijing Dongcheng District Health Commission
   (Grant No. [2018] 13) ; Key Laboratory of Trauma and Neural
   Regener-ation (Peking University) , Ministry of Education (Grant No.
   BMU2019XY00701) ; and Ministry of Education Innovation Program of China
   (Grant No. IRT_16R01) .
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NR 22
TC 32
Z9 42
U1 2
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2214-031X
J9 J ORTHOP TRANSL
JI J. Orthop. Transl.
PD JUL
PY 2021
VL 29
BP 100
EP 105
DI 10.1016/j.jot.2021.04.006
EA MAY 2021
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA TZ6EE
UT WOS:000684563000013
PM 34136348
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Greene, B
   Lagrotteria, A
   Tsang, ME
   Jayaraman, S
AF Greene, Brittany
   Lagrotteria, Andrew
   Tsang, Melanie E.
   Jayaraman, Shiva
TI Closed incision negative pressure wound therapy following
   pancreaticoduodenectomy for prevention of surgical site infections in
   high-risk patients
SO CANADIAN JOURNAL OF SURGERY
LA English
DT Article
ID PANCREATIC FISTULA; IMPACT; COMPLICATIONS
AB Background:Surgical site infection (SSI) is one of the most common sources of morbidity after pancreaticoduodenectomy. Surgical site infections are associated with readmissions, prolonged length of stay, delayed initiation of adjuvant chemotherapy and negative effects on quality of life. Incisional vacuum-assisted closure (iVAC) devices applied on closed incisions may reduce SSI rates. The objective of this retrospective review is to evaluate the impact of iVAC on SSI rate after pancreaticoduodenectomy.Methods:A cohort of patients undergoing pancreaticoduodenectomy at a single institution who had at least 1 risk factor for SSI and who received an iVAC were compared with a historical cohort of high-risk patients who received conventional dressings after pancreaticoduodenectomy. The primary outcome was incidence of SSI within 30 days, abstracted from chart review. Secondary outcomes were 30-day readmission, 90-day mortality, rate of postoperative pancreatic fistula and rate of delayed gastric emptying.Results:In total, 175 patients were included, of whom 61 received an iVAC. The incidence of SSI was 13% (8 of 61 patients) and 16% (18 of 114 patients) in the iVAC and conventional dressing groups, respectively (odds ratio 0.81, 95% confidence interval 0.33-1.98). Preoperative biliary drainage was the most frequent SSI risk factor. Binary logistic regression using SSI as the outcome demonstrated no significant association with iVAC use when adjusted for SSI risk factors. There were no differences in rates of postoperative pancreatic fistula, delayed gastric emptying or 90-day mortality.Conclusion:This report describes the outcomes of the integration of iVAC devices into routine clinical practice at a high-volume institution. Application of this device after pancreaticoduodenectomy for patients at elevated risk of SSI was not associated with a reduction in the rate of SSIs.
   Contexte:L'infection de la plaie operatoire (IPO) est l'une des principales causes de morbidite apres la pancreatoduodenectomie. Les IPO sont associees a des readmissions, au prolongement des sejours hospitaliers et au report de la chimiotherapie adjuvante, en plus de nuire a la qualite de vie. Le traitement des plaies par pression negative (TPN) applique sur des incisions refermees pourrait reduire les taux d'IPO. Cette etude retrospective avait pour objectif de mesurer l'impact du TPN sur le taux d'IPO apres la pancreatoduodenectomie.Methodes:Dans un seul et meme etablissement, une cohorte de malades soumis a une pancreatoduodenectomie presentant au moins 1 facteur de risque d'IPO et ayant beneficie du TPN a ete comparee a une cohorte historique de cas a risque eleve chez qui on a applique des pansements classiques apres la pancreatoduodenectomie. Le parametre principal etait l'incidence des IPO dans les 30 jours suivant l'intervention, selon la revue des dossiers. Les parametres secondaires etaient les readmissions dans les 30 jours, la mortalite dans les 90 jours, et les taux de fistules postoperatoires et de retards de la vidange gastrique.Resultats:En tout, 175 malades ont ete inclus, dont 61 ont recu le TPN. L'incidence des IPO a ete de 13 % (8 malades sur 61) et de 16 % (18 malades sur 114) dans les groupes ayant recu le TPN et les pansements classiques, respectivement (rapport des cotes 0,81, intervalle de confiance de 95 % 0,33-1,98). Le drainage biliaire preoperatoire etait le facteur de risque d'IPO le plus frequent. La regression logistique binaire avec l'IPO comme parametre n'a permis d'etablir aucun lien significatif avec le TPN apres ajustement pour tenir compte des facteurs de risque d'IPO. On n'a note aucune difference quant aux taux de fistules pancreatiques postoperatoires, aux retards de la vidange gastrique ou a la mortalite a 90 jours.Conclusion:Ce rapport decrit l'impact de l'integration des systemes de TPN dans la pratique clinique habituelle d'un etablissement achalande. L'utilisation de tels dispositifs apres la pancreatoduodenectomie en presence d'un risque eleve d'IPO n'a pas ete associee a une reduction du taux d'IPO.
C1 [Greene, Brittany] Washington Univ Sch Med St Louis, Div Gen Surg, Sect Hepatobiliary Pancreat & Gastrointestinal Su, Div Gen Internal Med & Endocrinol & Metab, St Louis, MO USA.
   [Lagrotteria, Andrew] Univ Toronto, Temerty Fac Med, Toronto, ON, Canada.
   [Tsang, Melanie E.] Univ Toronto, Temerty Fac Med, Dept Surg, Div Gen Surg, Toronto, ON, Canada.
   [Tsang, Melanie E.; Jayaraman, Shiva] St Josephs Hlth Ctr, Div Gen Surg, Unity Hlth Toronto, Ont can, Toronto, ON, Canada.
   [Jayaraman, Shiva] Unity Hlth Toronto, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Jayaraman, Shiva] Univ Toronto, St Josephs Hlth Ctr HPB Serv, HPB Outpatient Ctr, 1600 Bloor St W, Toronto, ON M6P 1A7, Canada.
C3 Washington University (WUSTL); University of Toronto; University of
   Toronto; University of Toronto; Saint Joseph's Health Centre, Toronto;
   Western University (University of Western Ontario); University Western
   Ontario Hospital; University of Toronto; Li Ka Shing Knowledge
   Institute; University of Toronto
RP Jayaraman, S (通讯作者)，Univ Toronto, St Josephs Hlth Ctr HPB Serv, HPB Outpatient Ctr, 1600 Bloor St W, Toronto, ON M6P 1A7, Canada.
EM shiva.jayaraman@unityhealth.to
OI Jayaraman, Shiva/0009-0004-4487-3521; Tsang, Melanie/0000-0003-3395-9819
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NR 19
TC 4
Z9 4
U1 0
U2 2
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 5W8, CANADA
SN 0008-428X
EI 1488-2310
J9 CAN J SURG
JI Can. J. Surg.
PY 2023
VL 66
IS 5
BP E507
EP E512
DI 10.1503/cjs.000723
EA DEC 2023
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA W4JW8
UT WOS:001091314000001
PM 37875305
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sandy-Hodgetts, K
   Parsons, R
   Norman, R
   Fear, MW
   Wood, FM
   White, SW
AF Sandy-Hodgetts, Kylie
   Parsons, Richard
   Norman, Richard
   Fear, Mark W.
   Wood, Fiona M.
   White, Scott W.
TI Effectiveness of negative pressure wound therapy in the prevention of
   surgical wound complications in the cesarean section at-risk population:
   a parallel group randomised multicentre trial-the CYGNUS protocol
SO BMJ OPEN
LA English
DT Article
DE wound management; surgery; obstetrics; clinical trials
ID CLINICAL-TRIALS; DELIVERY; PATIENT
AB Introduction Caesarean delivery is steadily becoming one of the more common surgical procedures in Australia with over 100 000 caesarean sections performed each year. Over the last 10 years in Australia, the caesarean section rate has increased from 28% in 2003 to 33% in 2013. On the international stage, the Australian caesarean delivery rates are higher than the average for the Organisation for Economic Co-operation and Development, Australia ranked as 8 out of 33 and is second to the USA. Postoperative surgical site infections (SSIs) and wound complications are the most common and costly event following a caesarean section. Globally, complication rates following a caesarean delivery vary from 4.9% to 9.8%. Complications such as infection and wound breakdown affect the postpartum mother's health and well-being, and contribute to healthcare costs for clinical management that often spans the acute, community and primary healthcare settings. Published level one studies using advanced wound dressings in the identified 'at-risk' population prior to surgery for prophylactic intervention are yet to be forthcoming. Methods and analysis A parallel group randomised control trial of 448 patients will be conducted across two metropolitan hospitals in Perth, Western Australia, which provide obstetric and midwifery services. We will recruit pregnant women in the last trimester, prior to their admission into the healthcare facility for delivery of their child. We will use a computer-generated block sequence to randomise the 448 participants to either the interventional (negative pressure wound therapy (NPWT) dressing, n=224) or comparator arm (non-NPWT dressing, n=224). The primary outcome measure is the occurrence of surgical wound dehiscence (SSWD) or SSI. The Centres for Disease Control reporting definition of either superficial or deep infection at 30 days will be used as the outcome measure definition. SWD will be classified as per the World Union of Wound Healing Societies grading system (grade I-IV). We will assess recruitment rate, and adherence to intervention and follow-up. We will assess the potential effectiveness of NPWT in the prevention of postpartum surgical wound complications at three time points during the study; postoperative days 5, 14 and 30, after which the participant will be closed out of the trial. We will use statistical methods to determine efficacy, and risk stratification will be conducted to determine the SWD risk profile of the participant. Follow-up at day 30 will assess superficial and deep infection, and wound dehiscence (grade I-IV) and the core outcome data set for wound complications. This study will collect health-related quality of life (European Quality of Life 5-Dimensions 5-Level Scale), mortality and late complications such as further surgery with a cost analysis conducted. The primary analysis will be by intention-to-treat. This clinical trial protocol follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and the Consolidated Standards of Reporting Trials guidelines. Ethics and dissemination Ethics approval was obtained through St John of God Health Care (HREC1409), Western Australia Department of Health King Edward Memorial Hospital (HREC3111). Study findings will be published in peer-reviewed journals and presented at international conferences. We used the SPIRIT checklist when writing our study protocol.
C1 [Sandy-Hodgetts, Kylie] Univ Western Australia, Sch Biomed Sci, Skin Integr Res Inst, Crawley, WA, Australia.
   [Parsons, Richard] Curtin Univ, Fac Hlth Sci, Sch Occupat Therapy Social Work & Speech Pathol, Perth, WA, Australia.
   [Norman, Richard] Curtin Univ, Fac Hlth Sci, Sch Publ Hlth, Perth, WA, Australia.
   [Fear, Mark W.] Univ Western Australia, Sch Biomed Sci, Burn Injury Res Unit, Crawley, WA, Australia.
   [Wood, Fiona M.] Fiona Stanley Hosp, Burns Serv Western Australia, Perth, WA, Australia.
   [Wood, Fiona M.] Princess Margaret Hosp, Burns Serv Western Australia, Perth, WA, Australia.
   [White, Scott W.] Univ Western Australia, Fac Hlth & Med Sci, Dept Obstet & Gynaecol, Perth, WA, Australia.
   [White, Scott W.] King Edward Mem Hosp, Maternal Fetal Med Serv, Subiaco, WA, Australia.
C3 University of Western Australia; Curtin University; Curtin University;
   University of Western Australia; South Metropolitan Health Service;
   Fiona Stanley Fremantle Hospitals Group; Fiona Stanley Hospital; Perth
   Childrens Hospital; University of Western Australia; University of
   Western Australia; University of Western Australia; King Edward Memorial
   Hospital
RP Sandy-Hodgetts, K (通讯作者)，Univ Western Australia, Sch Biomed Sci, Skin Integr Res Inst, Crawley, WA, Australia.
EM kylie.sandy-hodgetts@uwa.edu.au
RI Sandy-Hodgetts, Kylie/A-7494-2019; fiona, wood/F-4703-2013; fear,
   mark/H-9170-2014
OI Sandy-Hodgetts, Kylie/0000-0001-6848-2526; fiona,
   wood/0000-0001-5427-6588; fear, mark/0000-0003-3163-4666; White,
   Scott/0000-0002-7235-6407
FU ConvaTec [UWA52001100]
FX This work is funded by an unrestricted educational grant from ConvaTec.
   Grant ID UWA52001100.
CR ACSQH, 2017, NAT SAF QUAL HLTH SE, V2nd
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NR 24
TC 4
Z9 5
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 10
AR e035727
DI 10.1136/bmjopen-2019-035727
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OM0SA
UT WOS:000585738900003
PM 33077559
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Bertges, DJ
   Smith, L
   Scully, RE
   Wyers, M
   Eldrup-Jorgensen, J
   Suckow, B
   Ozaki, CK
   Nguyen, L
AF Bertges, Daniel J.
   Smith, Lisa
   Scully, Rebecca E.
   Wyers, Mark
   Eldrup-Jorgensen, Jens
   Suckow, Bjoern
   Ozaki, C. Keith
   Nguyen, Louis
CA PREVENA Trial Investigators
TI A multicenter, prospective randomized trial of negative pressure wound
   therapy for infrainguinal revascularization with a groin incision
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 47th Annual Meeting of the New-England-Society-for-Vascular-Surgery
CY SEP 11-13, 2020
CL ELECTR NETWORK
SP New England Soc Vasc Surg
DE Groin wound; Infrainguinal revascularization; Negative pressure wound
   therapy; PREVENA; Surgical site infection
ID SURGICAL SITE INFECTION; LOWER-EXTREMITY BYPASS; AMERICAN-COLLEGE;
   COMPLICATIONS; SOCIETY; GUIDELINES; MANAGEMENT; SURGEONS; IMPACT
AB Background: Wound complications after open infrainguinal revascularization are a frequent cause of patient morbidity, resulting in increased healthcare costs. The purpose of the present study was to assess the effects of closed incision negative pressure therapy (ciNPT) on groin wound complications after infrainguinal bypass and femoral endarterectomy.
   Methods: A total of 242 patients who had undergone infrainguinal bypass (n = 124) or femoral endarterectomy (n = 118) at five academic medical centers in New England from April 2015 to August 2019 were randomized to ciNPT (PREVENA; 3M KCI, St Paul, Minn; n = 118) or standard gauze (n = 124). The primary outcomemeasure was a composite endpoint of groin wound complications, including surgical site infections (SSIs), major noninfectious wound complications, or graft infections within 30 days after surgery. The secondary outcome measures included 30-day SSIs, 30-day noninfectious wound complications, readmission for wound complications, significant adverse events, and health-related quality of life using the EuroQoL 5D-3L survey.
   Results: The ciNPT and control groups had similar demographics (age, 67 vs 67 years, P = .98; male gender, 71% vs 70%, P = .86; white race, 93% vs 93%, P = .97), comorbidities (previous or current smoking, 93% vs 94%, P = .46; diabetes, 41% vs 48%, P = .20; renal insufficiency, 4% vs 7%, P = .31), and operative characteristics, including procedure type, autogenous conduit, and operative time. No differences were found in the primary composite outcome at 30 days between the two groups (ciNPT vs control: 31% vs 28%; P = .55). The incidence of SSI at 30 days was similar between the two groups (ciNPT vs control: 11% vs 12%; P = .58). Infectious (13.9% vs 12.6%; P = .77) and noninfectious (20.9% vs 17.6%; P = .53) wound complications at 30 days were also similar for the ciNPT and control groups. Wound complications requiring readmission also similar between the two groups (ciNPT vs control: 9% vs 7%; P = .54). The significant adverse event rates were not different between the two groups (ciNPT vs control: 13% vs 16%; P = .53). The mean length of the initial hospitalization was the same for the ciNPT and control groups (5.2 vs 5.7 days; P = .63). The overall health-related quality of life was similar at baseline and at 14 and 30 days postoperatively for the two groups. Although not powered for stratification, we found no differences among the subgroups in gender, obesity, diabetes, smoking, claudication, chronic limb threatening ischemia, bypass, or endarterectomy. On multivariable analysis, no differences were found in wound complications at 30 days for the ciNPT vs gauze groups (odds ratio, 1.4; 95% confidence interval, 0.8-2.6; P = .234).
   Conclusions: In contrast to other randomized studies, our multicenter trial of infrainguinal revascularization found no differences in the 30-day groin wound complications for patients treated with ciNPT vs standard gauze dressings. However, the SSI rate was lower in the control group than reported in other studies, suggesting other practice patterns and processes of care might have reduced the rate of groin infections. Further study might identify the subsets of highrisk patients that could benefit from ciNPT.
C1 [Bertges, Daniel J.] Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
   [Smith, Lisa] Univ Vermont, Off Clin Trials Res, Coll Med, Burlington, VT 05401 USA.
   [Scully, Rebecca E.; Ozaki, C. Keith; Nguyen, Louis] Brigham & Womens Hosp, Div Vasc & Endovasc Surg, Boston, MA USA.
   [Wyers, Mark] Beth Israel Deaconess Med Ctr, Div Vasc Surg, Boston, MA USA.
   [Eldrup-Jorgensen, Jens] Maine Med Ctr, Div Vasc Surg, Portland, ME USA.
   [Suckow, Bjoern] Dartmouth Hitchcock Med Ctr, Sect Vasc Surg, Lebanon, NH USA.
C3 University of Vermont; University of Vermont Medical Center; University
   of Vermont; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Maine Medical
   Center; Dartmouth College
RP Bertges, DJ (通讯作者)，Univ Vermont, Div Vasc Surg, Med Ctr, 111 Colchester Ave,Smith 338, Burlington, VT 05401 USA.
EM daniel.bertges@uvmhealth.org
RI Ozaki, C/A-4937-2013; Scully, Rebecca/AEK-5018-2022
OI Scully, Rebecca/0000-0002-6887-9600
FU Acelity KCI (San Antonio, Tex)
FX The present investigator-initiated study was funded by Acelity KCI (San
   Antonio, Tex).
CR Acosta S, 2017, BJS-BRIT J SURG, V104, pE75, DOI 10.1002/bjs.10403
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   Benrashid E, 2020, J VASC SURG, V71, P896, DOI 10.1016/j.jvs.2019.05.066
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   Davis FM, 2017, J VASC SURG, V65, P1769, DOI 10.1016/j.jvs.2016.11.053
   de Lissovoy G, 2009, AM J INFECT CONTROL, V37, P387, DOI 10.1016/j.ajic.2008.12.010
   Dua A, 2014, J VASC SURG, V60, P1635, DOI 10.1016/j.jvs.2014.08.072
   Engelhardt M, 2018, INT WOUND J, V15, P327, DOI 10.1111/iwj.12848
   EQ-5D, EQ 5D
   Gombert A, 2020, VASCULAR, V28, P274, DOI 10.1177/1708538119890960
   Gombert A, 2018, EUR J VASC ENDOVASC, V56, P442, DOI 10.1016/j.ejvs.2018.05.018
   Greenblatt DY, 2011, J VASC SURG, V54, P433, DOI 10.1016/j.jvs.2011.01.034
   Hasselmann J, 2020, ANN SURG, V271, P48, DOI 10.1097/SLA.0000000000003364
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   Zhang JQ, 2014, J VASC SURG, V59, P1331, DOI 10.1016/j.jvs.2013.12.032
NR 35
TC 24
Z9 27
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD JUL
PY 2021
VL 74
IS 1
BP 257
EP +
DI 10.1016/j.jvs.2020.12.100
EA JUN 2021
PG 12
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA SW1OZ
UT WOS:000664291100033
PM 33548422
OA Bronze
DA 2026-07-24
ER

PT J
AU Chua, KYL
   Grayson, ML
   Burgess, AN
   Lee, JYH
   Howden, BP
AF Chua, Kyra Y. L.
   Grayson, M. Lindsay
   Burgess, Adele N.
   Lee, Jean Y. H.
   Howden, Benjamin P.
TI The growing burden of multidrug-resistant infections among returned
   Australian travellers
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Editorial Material
ID GRAM-NEGATIVE RESISTANCE; KLEBSIELLA-PNEUMONIAE; COMBAT
AB Clinical record
   A previously well 66-year-old man was repatriated from Athens, Greece, to the Austin Hospital for ongoing management after a protracted hospital admission for an ischiorectal abscess secondary to perforated diverticulitis. This was complicated by faeculent peritonitis, multiple intra-abdominal abscesses and necrotising fasciitis of the abdominal watt These complex problems required multiple laparotomies to drain and debride the abscesses, management of an open abdomen with vacuum-assisted closure dressings, and the formation of a loop sigmoidostomy. He also developed a grade IV sacral pressure ulcer with underlying sacral osteomyelitis. Organisms isolated from the intra-abdominal collections included carbapenem-resistant Pseudomonas aeruginosa and a carbapenemase-producing Klebsiella pneumoniae (bla(KPC)). Due to the complexity of the patient's illness, he had spent 93 days in hospital in Greece, predominantly in intensive care, with three interhospital transfers within Greece before repatriation to Australia. Antibiotics administered in Greece included tigecycline, colistin, fosfomycin, vancomycin, clindamycin and anidulafungin.
   As the patient had multiple resistant organisms, detailed infection control plans were made before his arrival at the Austin Hospital. This included placement in a single room with a dedicated ensuite bathroom, daily bleach cleaning of the room,(1) no use of shared equipment, enforcement of strict contact precautions including gowns and gloves, and hand hygiene. Patient movement was severely restricted and only two visitors were allowed at any one time.
   Unfortunately, the patient developed a new intra-abdominal collection, bowel obstruction and abdominal sepsis. This required surgical intervention, including extensive division of adhesions, resection of the sigmoid and part of the descending colon, retroperitoneal enteric fistula repair and retroperitoneal abscess drainage. An end colostomy and loop ileostomy were formed. This procedure resulted in faecal continence and therefore control of the perianal source of multidrug-resistant organisms. Culture of the intra-abdominal abscess grew mixed enteric flora including Enterococcus faeclum, Escherichia coli, Citrobacter spp, Candida glabrata and K. pneumoniae. The latter organism was resistant to multiple drugs, including meropenem, due to the production of K. pneumoniae carbapenemase-2 (bla(KPC-2)) (Patient 1, Box). The same organism was found in his faeces.
   A bla(KPC-2)-producing K. pneumoniae was also isolated from a sacral ulcer swab, but the susceptibility profile was slightly different. This isolate was also resistant to all aminoglycosides, including gentamicin and amikacin, and demonstrated an increased minimum Inhibitory concentration to colistin (Box). The patient's antibiotic treatment included meropenem, tigecycline, colistin and caspofungin for 6 weeks, and his sacral ulcer was treated with a vacuum-assisted closure dressing. He stayed at the Austin Hospital for 101 days before being discharged home.
   Six months later, the patient re-presented to the Austin Hospital with urosepsis. The causative organism, isolated in both urine and blood, was E. coli (Box). Strikingly, the organism was found to be a bla(KPC-2)-producing strain, suggesting interspecies transfer of this mobile genetic element between K. pneumoniae and E. coli. Unlike the K. pneumoniae, this isolate was susceptible to ciprofloxacin, and the patient was successfully treated with this antibiotic. During this second admission, the same infection control measures were enforced.
   At follow-up 6 months later, the patient remained well. There was no documented inhospital transmission of bla(KPC-2), suggesting the infection control measures employed were successful.
C1 [Chua, Kyra Y. L.; Grayson, M. Lindsay; Burgess, Adele N.; Lee, Jean Y. H.; Howden, Benjamin P.] Austin Hlth, Melbourne, Vic, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Austin Research Institute
RP Chua, KYL (通讯作者)，Austin Hlth, Melbourne, Vic, Australia.
EM benjamin.howden@austin.org.au
RI Lee, Jean/MVX-4604-2025; Howden, Benjamin/KHY-6363-2024
OI Lee, Jean/0000-0001-5751-8503; Howden, Benjamin/0000-0003-0237-1473
CR Australian Bureau of Statistics, 2013, OV ARR DEP
   Australian Commission on Safety and Quality in Health Care, 2013, REC CONTR MULT RES G
   Ellem J, 2011, J CLIN MICROBIOL, V49, P3074, DOI 10.1128/JCM.02647-10
   Grabsch EA, 2012, J HOSP INFECT, V82, P234, DOI 10.1016/j.jhin.2012.08.010
   Kennedy K, 2010, EUR J CLIN MICROBIOL, V29, P1501, DOI 10.1007/s10096-010-1031-y
   Kollef MH, 2011, CLIN INFECT DIS, V53, pS33, DOI 10.1093/cid/cir475
   Looke DFM, 2013, MED J AUSTRALIA, V198, P243, DOI 10.5694/mja13.10190
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   Souli M, 2010, CLIN INFECT DIS, V50, P364, DOI 10.1086/649865
   Turnidge JD, GRAM NEGATIVE SURVEY
   Tzouvelekis LS, 2012, CLIN MICROBIOL REV, V25, P682, DOI 10.1128/CMR.05035-11
   Yezli S, 2012, INT J ANTIMICROB AG, V40, P389, DOI 10.1016/j.ijantimicag.2012.07.009
NR 12
TC 16
Z9 19
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0025-729X
EI 1326-5377
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD FEB 3
PY 2014
VL 200
IS 2
BP 116
EP 118
DI 10.5694/mja13.10592
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AB1YO
UT WOS:000331590100032
PM 24484117
DA 2026-07-24
ER

PT J
AU Tsouknidas, I
   Tibbets, G
   Angistriotis, A
   Koullias, G
AF Tsouknidas, Ioannis
   Tibbets, Garrett
   Angistriotis, Athanasios
   Koullias, George
TI A Multimodal Approach for Limb Preservation of Dehisced Amputations with
   Bone Exposure
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID LOWER-EXTREMITY AMPUTATION; RISK-FACTORS; READMISSION; DISEASE
AB Background: The prevalence of nontraumatic amputations continues to rise annually. The length of the preserved limb is directly associated with the success of ambulation. Wound infections after lower extremity amputations are very common, and reoperation is necessary in up to 61%. When dehisced stumps are complicated by bone exposure and osteomyelitis, more proximal amputation is traditionally performed. Methods: A retrospective chart review of the electronic medical records from 2018 to 2024 was conducted at our institution, and dehisced amputated stumps with bone exposure were included for final analysis. All cases were treated with a novel seven-step treatment algorithm, incorporating aggressive revascularization, as well as standard and advanced wound care modalities. Data collection included patient characteristics, treatment details, and follow-up outcomes. Results: A total of 22 dehisced stumps with osteomyelitis, from 19 patients (73.7% male, 26.3% female), with an average wound size of 27.4 cm(2) were included. Fourteen revascularization procedures were performed. Negative pressure wound therapy, collagen products, and amniotic or acellular matrix dressings were used in 54.5%, 68.2%, and 72.7% of the stumps, respectively. Complete healing was achieved in all patients with an average healing time of 171.8 days. Wound recurrence occurred in two stumps. The mean wound-free period was 323.9 days. Conclusion: The proposed treatment algorithm enables successful closure of dehisced stumps with bone exposure in selected patients. Adherence to the treatment and close follow-up are essential for optimal outcomes.
C1 [Tsouknidas, Ioannis] Lankenau Med Ctr, Dept Surg, Wynnewood, PA USA.
   [Tsouknidas, Ioannis; Tibbets, Garrett; Angistriotis, Athanasios; Koullias, George] Stony Brook Southampton Hosp, Dept Surg, Southampton, NY USA.
   [Tsouknidas, Ioannis; Tibbets, Garrett; Angistriotis, Athanasios] Stony Brook Univ Hosp, Dept Surg, Stony Brook, NY USA.
   [Koullias, George] Stony Brook Univ Hosp, Dept Surg, Div Vasc & Endovascular Surg, Stony Brook, NY USA.
   [Koullias, George] Stony Brook Univ Hosp, Limb Preservat Ctr, Div Vasc & Endovascular Surg, Stony Brook, NY USA.
   [Koullias, George] Catholic Hlth Syst, St Catherine Siena Hosp, Div Vasc & Endovascular Surg, Catholic Hlth Syst Chief Limb Preservat, Smithtown, NY USA.
C3 Lankenau Medical Center; State University of New York (SUNY) System;
   Stony Brook University; Stony Brook University Hospital; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; State University of New York (SUNY) System;
   Stony Brook University; Stony Brook University Hospital
RP Koullias, G (通讯作者)，Catholic Syst, St Catherine Siena Hosp, Div Vasc & Surg, 50 NY-25A, Smithtown, NY 11787 USA.
EM gkoullias@yahoo.com
RI ; Tsouknidas, Ioannis/AAL-7816-2021
OI Tibbets, Garrett/0009-0003-8612-0053; Tsouknidas,
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JAN
PY 2026
VL 122
BP 713
EP 722
DI 10.1016/j.avsg.2025.09.019
EA OCT 2025
PG 10
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 8PU6R
UT WOS:001594440800001
PM 40975212
DA 2026-07-24
ER

EF