﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Baillot, R
   Cloutier, D
   Montalin, L
   Côté, L
   Lellouche, F
   Houde, C
   Gaudreau, G
   Voisine, P
AF Baillot, Richard
   Cloutier, Daniel
   Montalin, Livia
   Cote, Louise
   Lellouche, Francois
   Houde, Chanel
   Gaudreau, Genevieve
   Voisine, Pierre
TI Impact of deep sternal wound infection management with vacuum-assisted
   closure therapy followed by sternal osteosynthesis: a 15-year review of
   23 499 sternotomies
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Mediastinitis; VAC therapy; Sternal osteosynthesis
ID LONG-TERM SURVIVAL; POSTOPERATIVE MEDIASTINITIS; FIXATION;
   VASCULARIZATION; DEHISCENCE
AB Objective: This study was undertaken to examine the outcome of patients with deep sternal wound infection (DSWI) now treated with vacuum-assisted closure (VAC) therapy as a bridge to sternal osteosynthesis with horizontal titanium plate fixation. Methods: From 1992 to 2007, a consecutive cohort of 23 499 patients underwent open-heart surgery (OHS) in our institution. The period under study was divided in two according to the use of therapeutic modalities: conventional (1992-2001, N = 118 DSWI): debridement/drainage with primary closure and irrigation (N = 37), debridement/drainage, open packing followed by pectoralis myocutaneous flaps (PMFs) (N = 81); contemporary (2002-2007, N = 149 DSWI): conventional treatment (N = 24) and VAC therapy (N = 125/83.8%). VAC was followed by sternal osteosynthesis with horizontal titanium plates in 92 patients (61.7%). Results: DSWI was diagnosed in 267 out of 23 499 (1.1%) patients of our entire series according to Center for Disease Control Atlanta (CDC) criteria, 118 out of 13 180 (0.9%) in the first and 149 out of 10 319 (1.4%) in the second period (p = 0.001). Hospital mortality (N = 267/23 499) has been 10.25% for the entire cohort under study without any difference between groups (1992-2001: 11.4%; 2002 2007: 9.1%, p = 0.67). More recently, VAC therapy (N = 125) was associated with a lower mortality (4.8% vs 14.1%, p = 0.01). Stepwise multivariable logistic regression analysis for both periods revealed that prolonged intubation in the intensive care unit (ICU), use of bilateral internal thoracic artery grafting (BIMA), diabetes, re-operation for bleeding and body mass index (BMI) >30 kg m(2) are the most powerful predictors of DSWI. In the more recently treated patients using VAC therapy, combined procedures (valve and graft) also emerged as a significant predictor. For the entire study, Staphylococcus epidermidis (49.6%) has been the most frequently identified pathogen, followed by Staphylococcus aureus (38.8%). Methiciltin-resistant S. aureus (MRSA) was observed in 4.9% of the cohort. Neither of these bacteria was associated with increased mortality. Survival analysis with Cox regression model and propensity score adjustment in patients with DSWI showed freedom from all-cause mortality at 1, 5 and 10 years to be, respectively, 91.8%, 80.4% and 61.3% compared with 94.0%, 85.5% and 70.2%, respectively, for patients submitted to OHS without DSWI (p = 0.01). Early adjusted survival for patients with DSWI treated with VAC therapy was 92.8%, 89.8% and 88.0%, respectively, at 1, 2 and 3 years, compared with 83.0%, 76.4% and 61.3%, respectively, for patients with DSWI treated without VAC (p = 0.02). Conclusions: DSWI remains a major and challenging complication of OHS. VAC therapy with sternal preservation followed by delayed sternal osteosynthesis and PMF has been recently proposed as a new therapeutic strategy. Most patients treated with VAC therapy in our second group showed decreased perioperative mortality and increased short-term survival. (C) 2009 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Baillot, Richard; Cloutier, Daniel; Montalin, Livia; Houde, Chanel; Gaudreau, Genevieve; Voisine, Pierre] Univ Laval, Dept Cardiac, Quebec City, PQ, Canada.
   [Baillot, Richard; Cloutier, Daniel; Montalin, Livia; Houde, Chanel; Gaudreau, Genevieve; Voisine, Pierre] Univ Laval, Dept Plast Surg, Quebec City, PQ, Canada.
   [Lellouche, Francois] Laval Hosp, Res Ctr, Quebec City, PQ, Canada.
   [Cote, Louise] Univ Laval, Dept Med Biol, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Laval University
RP Baillot, R (通讯作者)，Hop Laval, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
EM richard.baillot@chg.ulaval.ca
RI Lellouche, Francois/AAB-9014-2019
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NR 25
TC 125
Z9 141
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2010
VL 37
IS 4
BP 880
EP 887
DI 10.1016/j.ejcts.2009.09.023
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 588DN
UT WOS:000277047700027
PM 19880326
OA Bronze
DA 2026-07-24
ER

PT J
AU Fang, CL
   Changchien, CH
   Chen, MS
   Hsu, CH
   Tsai, CB
AF Fang, Chien-Liang
   Changchien, Chih-Hsuan
   Chen, Ming-Shan
   Hsu, Chin-Hao
   Tsai, Chong-Bin
TI Closed incision negative pressure therapy following abdominoplasty after
   breast reconstruction with deep inferior epigastric perforator flaps
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE breast reconstruction; cicatrix; negative pressure wound therapy;
   surgical wound; wound healing
ID DIEP
AB Autologous breast reconstructions using deep inferior epigastric perforator (DIEP) flaps create a large incision, presenting an opportunity for surgical site complications. In this pilot study, we aimed to examine outcomes in DIEP donor site incisions managed with standard dressings (control; n = 5) or closed incision negative pressure therapy (ciNPT; n = 5). We observed no significant differences between group age, body mass index, and past medical history. Both treatment groups had a similar duration of hospital stay, the number of blood transfusions, and pain scores on postoperative day 2 (P > .05). There was a trend of higher drainage (P = .251) and shorter time to incision healing (P = .067) in the ciNPT group than the control though the difference was not statistically significant. We did observe a significant improvement in scar pigmentation, vascularity, and pliability at 3, 6, and 12 months post-surgery in the ciNPT group compared with control (P < .05). No surgical site complications were reported in the ciNPT group within the follow-up period. In the control group, one patient developed wound edge fat necrosis requiring reoperation. In conclusion, we report that ciNPT is a useful incision management system for DIEP flap donor site incisions and it facilitated improved scar quality over standard dressings in this small pilot study. Further clinical studies are required to assess the full advantages provided by ciNPT.
C1 [Fang, Chien-Liang; Changchien, Chih-Hsuan; Hsu, Chin-Hao] Ditmanson Med Fdn, Dept Surg, Div Plast & Reconstruct Surg, Chia Yi Christian Hosp, 539 Jhongsiao Rd, Chiayi 60002, Taiwan.
   [Fang, Chien-Liang] Asia Univ, Coll Med & Hlth Sci, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan.
   [Changchien, Chih-Hsuan; Chen, Ming-Shan] Asia Univ, Coll Med & Hlth Sci, Dept Biotechnol, Taichung, Taiwan.
   [Chen, Ming-Shan] Ditmanson Med Fdn, Dept Anesthesiol, Chia Yi Christian Hosp, Chiayi, Taiwan.
   [Tsai, Chong-Bin] Ditmanson Med Fdn, Dept Ophthalmol, Chia Yi Christian Hosp, Chiayi, Taiwan.
   [Tsai, Chong-Bin] Asia Univ, Coll Med & Hlth Sci, Dept Optometry, Taichung, Taiwan.
C3 Asia University Taiwan; Asia University Taiwan; Asia University Taiwan
RP Fang, CL (通讯作者)，Ditmanson Med Fdn, Dept Surg, Div Plast & Reconstruct Surg, Chia Yi Christian Hosp, 539 Jhongsiao Rd, Chiayi 60002, Taiwan.
EM fangcl68@hotmail.com
RI Fang, Chien-Liang/ABF-4536-2020
OI Fang, Chien-Liang/0000-0001-6437-8721
CR Abatangelo S, 2018, OBES SURG, V28, P2096, DOI 10.1007/s11695-018-3279-8
   Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
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NR 20
TC 25
Z9 29
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 326
EP 331
DI 10.1111/iwj.13273
EA NOV 2019
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000498840200001
PM 31777164
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Guo, K
   Gong, WB
   Zheng, T
   Hong, ZW
   Wu, XW
   Ren, HJ
   Wang, GF
   Gu, GS
   Nthumba, P
   Ren, JA
   Li, JS
AF Guo, Kun
   Gong, Wenbin
   Zheng, Tao
   Hong, Zhiwu
   Wu, Xiuwen
   Ren, Huajian
   Wang, Gefei
   Gu, Guosheng
   Nthumba, Peter
   Ren, Jianan
   Li, Jieshou
TI Clinical parameters and outcomes of necrotizing soft tissue infections
   secondary to gastrointestinal fistulas
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Necrotizing soft tissue infections; Gastrointestinal fistula; Outcome
ID FASCIITIS SECONDARY; MANAGEMENT; SEPSIS; SKIN; GUIDELINES; DIAGNOSIS;
   SURGERY; CARE
AB BackgroundNecrotizing soft tissue infections (NSTIs) is severe surgical infections which can occur following trauma or abdominal surgery. NSTIs secondary to gastrointestinal (GI) fistula is a rare but severe complication.MethodsA retrospective cohort study was performed on all subjects presenting with GI fistulas associated NSTIs were included. Clinical characteristics, microbiological profile, operations performed, and outcomes of patients were analyzed.ResultsBetween 2014 and 2017, 39 patients were finally enrolled. The mean age were 46.9years and male were the dominant. For the etiology of fistula, 25 (64.1%) of the patients was due to trauma. Overall, in-hospital death occurred in 15 (38.5%) patients. Microbiologic findings were obtained from 31 patients and Klebsiella pneumoniae was the most common species (41.0%). Eight patients were treated with an open abdomen; negative pressure wound therapy was used in 33 patients and only 2 patients received hyperbaric oxygen therapy. Younger age and delayed abdominal wall reconstruction repair were more common in trauma than in non-trauma. Non-survivors had higher APACHE II score, less source control<48h and lower platelet count on admission than survivors. Multiple organ dysfunction syndrome, multidrug-resistant organisms and source control failure were the main cause of in-hospital mortality.ConclusionsTrauma is the main cause of GI fistulas associated NSTIs. Sepsis continues to be the most important factor related to mortality. Our data may assist providing enlightenment for quality improvement in these special populations.
C1 [Guo, Kun; Zheng, Tao; Hong, Zhiwu; Wu, Xiuwen; Ren, Huajian; Wang, Gefei; Gu, Guosheng; Ren, Jianan; Li, Jieshou] Nanjing Univ, Dept Gen Surg, Sch Med, Jinling Hosp, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
   [Gong, Wenbin] Southeast Univ, Jinling Hosp, Dept Gen Surg, Sch Med, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
   [Nthumba, Peter] AIC Kijabe Hosp, Kijabe, Kenya.
C3 Nanjing University; Southeast University - China
RP Ren, JA (通讯作者)，Nanjing Univ, Dept Gen Surg, Sch Med, Jinling Hosp, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China.
EM guokunmedical@126.com; jiananr@gmail.com
RI Wu, Xiuwen/AEO-0814-2022; NTHUMBA, PETER/AEJ-0393-2022
OI Wu, Xiuwen/0000-0002-3813-3867; 
FU Key Project of Jiangsu Social Development [BE2016752]; Innovation
   Project of Military Medicine [16CXZ007]
FX The work was supported by grants from the Key Project of Jiangsu Social
   Development (BE2016752) and Innovation Project of Military Medicine
   (16CXZ007). The funders had no role in the design of the study and
   collection, analysis, and interpretation of data and in writing the
   manuscript.
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NR 36
TC 7
Z9 9
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUL 9
PY 2019
VL 19
AR 597
DI 10.1186/s12879-019-4248-0
PG 10
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA IJ2KE
UT WOS:000475730900005
PM 31288746
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ganz, OM
   Gumener, R
   Gervaz, P
   Schwartz, J
   Pittet-Cuénod, B
AF Ganz, Oanna Meyer
   Gumener, Raphael
   Gervaz, Pascal
   Schwartz, Julien
   Pittet-Cuenod, Brigitte
TI Management of unusual genital lymphedema complication after Fournier's
   gangrene: a case report
SO BMC SURGERY
LA English
DT Article
DE Fournier's gangrene; Penile lymphedema; Negative pressure wound therapy;
   Perineal reconstruction
ID MYOFASCIOCUTANEOUS ADVANCEMENT FLAP; SINGLE-STAGE RECONSTRUCTION;
   PERINEAL DEFECTS
AB Background: Fournier's gangrene is a bacterial infection characterized by necrotizing fasciitis, skin and soft tissue involvement, and eventually myositis of the perineal region. Aggressive debridement of devitalized tissue and overlying skin is of paramount importance, but often leaves large defects to be reconstructed. The present case reports successful extensive perineal defects coverage following Fournier's gangrene and management of subsequent penile lymphoedema impairing sexual function in a young patient.
   Case presentation: Following perianal abscess drainage, a healthy young man presented with scrotal pain. Fournier's gangrene was diagnosed and treated with multiple surgical debridements. Tissue excision extended through the entire perineal area, base of the penile shaft, lower abdominal region, the inner thighs, and gluteal region, corresponding to 12% of the total body surface area. After serial debridements and negative pressure dressings, the defect was covered by two stages of skin grafting. Graft take was 90%. Healing was achieved without hypertrophic or retractile scar. However, chronic penile lymphedema remained and was first treated with compressive garments for 2 years. Upon failure of this conservative approach, we performed a circumcision, but only a "penile lift" allowed a satisfactory esthetical and functional result.
   Conclusion: Fournier's gangrene can be complicated by a chronic lymphedema of the penis. Conservative treatment is likely to fail in severe cases and can be treated surgically by "penile lift".
C1 [Ganz, Oanna Meyer; Gumener, Raphael; Pittet-Cuenod, Brigitte] Geneva Univ Hosp & Med Sch, Div Plast Reconstruct & Aesthet Surg, CH-1211 Geneva 14, Switzerland.
   [Gervaz, Pascal] Geneva Univ Hosp & Med Sch, Dept Surg, CH-1211 Geneva 14, Switzerland.
   [Schwartz, Julien] Geneva Univ Hosp & Med Sch, Div Urol, CH-1211 Geneva 14, Switzerland.
RP Ganz, OM (通讯作者)，Geneva Univ Hosp & Med Sch, Div Plast Reconstruct & Aesthet Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM oanna.meyer@hcuge.ch
OI Gervaz, Pascal/0000-0001-6926-8134
CR Binder JP, 2007, TECHNIQUES CHIRURGIC
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NR 11
TC 2
Z9 2
U1 1
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 23
PY 2012
VL 12
AR 26
DI 10.1186/1471-2482-12-26
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 077UD
UT WOS:000314052800001
PM 23259537
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, X
   Xiong, NN
   Hu, HL
   Zhang, J
   Hu, KW
   Chen, YL
   Cheng, LJ
AF Wang, Xue
   Xiong, Nana
   Hu, Huilin
   Zhang, Jing
   Hu, Kewei
   Chen, Yilin
   Cheng, Lijia
TI Bioactive wound dressings for diabetic foot ulcers: mechanisms,
   materials, and clinical translation
SO BIOMEDICAL MATERIALS
LA English
DT Review
DE diabetic foot ulcer; wound dressings; biomaterials; angiogenesis;
   inflammation; clinical translation; wound healing
AB Diabetic foot ulcers (DFUs) constitute a severe and formidable complication of diabetes, in which the healing process is hampered by neuropathy, vascular dysfunction, persistent inflammation, and oxidative stress. Conventional therapeutic approaches, such as debridement and negative pressure wound therapy, frequently fail to completely reinstate the healing cascade, thereby necessitating the development of advanced dressings capable of actively interacting with the wound microenvironment. This review systematically summarizes the recent advancements in DFU dressings, classifying them into traditional, natural polymer-based (chitosan, alginate, collagen), synthetic polymer-based (poly (lactic-co-glycolic acid), polyvinyl alcohol, polyethylene glycol), and multifunctional systems. A primary emphasis is placed on clarifying their mechanisms of action, especially in promoting angiogenesis, alleviating oxidative stress, facilitating the transition of macrophages from the pro-inflammatory M1 phenotype to the reparative M2 phenotype, and regulating crucial signaling pathways such as AMPK, Wnt/beta-catenin, and Nrf2/ARE. Although the preclinical evidence for numerous bioactive dressings is promising, their clinical translation remains restricted, with only a few (e.g. collagen-based, silver-alginate dressings), currently approved for utilization. Future research endeavors should prioritize the development of multifunctional and responsive dressings, supported by rigorous clinical validation through standardized evaluation and large-scale trials. This review offers a comprehensive and critical synthesis of the current evidence, highlighting both mechanistic understandings and the existing disparities between laboratory research and clinical application in DFU dressing technology.
C1 [Cheng, Lijia] Chengdu Univ, Sch Preclin Med, Chengdu 610106, Peoples R China.
   Chengdu Univ, Clin Med Coll & Affiliated Hosp, Sch Nursing, Chengdu 610106, Peoples R China.
C3 Chengdu University; Chengdu University
RP Cheng, LJ (通讯作者)，Chengdu Univ, Sch Preclin Med, Chengdu 610106, Peoples R China.
EM chenglijia@cdu.edu.cn
FU Natural Science Foundation of Sichuan Province, China [2022NSFSC1510];
   National College Student Innovation and Entrepreneurship Training
   Program of China [202511079002X]
FX This work was supported by the Natural Science Foundation of Sichuan
   Province, China (2022NSFSC1510), National College Student Innovation and
   Entrepreneurship Training Program of China (202511079002X).
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NR 118
TC 0
Z9 0
U1 0
U2 0
PU IOP Publishing Ltd
PI Bristol
PA No.2 The Distillery, Glassfields, Avon Street, Bristol, ENGLAND
SN 1748-6041
EI 1748-605X
J9 BIOMED MATER
JI Biomed. Mater.
PD JUN 1
PY 2026
VL 21
IS 3
AR 032003
DI 10.1088/1748-605X/ae6aec
PG 20
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA ID6MM
UT WOS:001769195400001
PM 42102866
OA hybrid
DA 2026-07-24
ER

PT J
AU Robertson, T
   Benitez, L
AF Robertson, Tracy
   Benitez, Leonard
TI Reduced Time to Skin Grafting in Chronic Wounds Using an Esterified
   Hyaluronic Acid Matrix and Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID LOW-FREQUENCY ULTRASOUND; ASSISTED CLOSURE VAC; TISSUE; ULCERS;
   NONCONTACT; SCAFFOLD
AB Introduction. The use of NPWT and eHAM can aid in the closure of chronic wounds with exposed bone and tendon. Objective. The authors examined the time to skin grafting and wound closure in 10 patients after treatment with either NPWT with eHAM (group 1, n = 5) or NPWT without eHAM (group 2, n = 5). Results. The average time to closure was similar between group 1 and group 2 (15.2 weeks vs 14.6 weeks) despite a nearly twofold greater initial wound area. However, the rate of wound closure per week was better in group 1 than in group 2 in terms of both area (9.0 cm(2) vs 6.8 cm(2)) and volume (12.3 cm(3) vs 5.4 cm(3)). In addition, the rate of wound closure per week at skin grafting was better in group 1 than group 2 in terms of both area (4.5 cm(2) vs 3.8 cm(2)) and volume (25.9 cm(3) vs 4.1 cm(3)). All patients in group 1 received skin grafts within 2 to 3 weeks after their second eHAM application. Conclusion. The results of this small case series suggest that eHAM has a synergistic effect when used in combination with NPWT for the treatment of chronic wounds with exposed bone and tendon.
C1 [Robertson, Tracy; Benitez, Leonard] McLaren Bay Reg, Bay City, MI USA.
RP Robertson, T (通讯作者)，Adv Total Wound Care, 912 S Euclid Ave, Bay City, MI 48706 USA.
EM trobertson@advancedtotalwoundcare.com
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NR 29
TC 2
Z9 2
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2023
VL 35
IS 5
BP 99
EP 107
DI 10.25270/wnds/21081
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA S5MW6
UT WOS:001071616600009
PM 37163655
DA 2026-07-24
ER

PT J
AU Melnychuk, I
   Juriga, J
AF Melnychuk, Igor
   Juriga, Julia
TI "Soap Scrap" Technique: A Tissue-Preserving Approach to Treating Wounds
   with Undermining or Pockets
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE closed-incision negative-pressure therapy; edge trenching; epibole; Fick
   diffusion principle; modified negative-pressure therapy; multilayered
   compression; negative-pressure wound therapy; soap scrap; undermining;
   wound pockets; wound edge; wound remodeling
AB This retrospective case series introduces a tissue-preserving approach to treat complicated wounds with undermined edges or wounds with pockets. Wounds with undermining or pockets are commonly encountered in clinical practice and can be difficult to manage when trying to achieve wound closure. Traditionally, epibolic edges need to be resected or cauterized with silver nitrate, whereas wound undermining or pockets need to be resected or unroofed. The method described herein consists of three components: sharp debridement of all undermined areas or inside walls of wound pockets, compression, and immobilization. Compression can be performed using multilayered compression alone, modified negative-pressure therapy, or both. Immobilization of all wound layers can be achieved using a brace, removable Cam Walker, or a cast.
   This article reports on 11 patients who had unfavorable upper and lower extremity wounds with undermined areas or wound pockets who were treated using this methodology. The average patient age was 73 years, and the average wound depth was 1.12 cm. The average undermined area was 1.7 (range, 0.2-5.0) cm. Wounds healed in an average of 9.1 weeks; all wounds healed between 3 and 15 weeks. This series demonstrates a novel tissue-preserving approach to treating wounds with undermining or wounds with pockets using debridement, immobilization, and compression.
C1 [Melnychuk, Igor] Edward Via Coll Osteopath Med Carolinas, Blacksburg, VA 24060 USA.
   [Melnychuk, Igor] Charles George VA Med Ctr, Wound Care Dept, Asheville, NC 28805 USA.
   [Juriga, Julia] Nova Southeastern Univ, Ft Lauderdale, FL USA.
C3 Edward Via College of Osteopathic Medicine (VCOM); Nova Southeastern
   University
RP Melnychuk, I (通讯作者)，Edward Via Coll Osteopath Med Carolinas, Blacksburg, VA 24060 USA.; Melnychuk, I (通讯作者)，Charles George VA Med Ctr, Wound Care Dept, Asheville, NC 28805 USA.
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NR 11
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD SEP
PY 2023
VL 36
IS 9
BP 495
EP 501
DI 10.1097/ASW.0000000000000008
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA P7EM0
UT WOS:001052268200014
PM 37530574
DA 2026-07-24
ER

PT J
AU Serena, TE
AF Serena, Thomas E.
TI USE OF EPIDERMAL GRAFTS IN WOUNDS: A REVIEW OF AN AUTOMATED EPIDERMAL
   HARVESTING SYSTEM
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE epidermal grafting; chronic wounds; wound healing
ID EXPOSING BONE-MARROW; THERAPY
AB Chronic wounds continue to present a significant challenge to health-care providers across the globe. Unlike acute wounds, chronic wounds do not proceed through an orderly process of repair. In recent years, a number of wound healing treatments, such as dermal replacement scaffolds and negative pressure wound therapy, have promoted wound healing by stimulating the formation of granulation tissue. However, until recently there were few modalities designed to promote epithelialisation of a fully granulated wound. Split-thickness skin grafts (STSGs) have long been the gold standard for the management of acute wounds, but have not gained favour in the treatment of chronic wounds for several reasons: discomfort associated with the donor site, the creation of a second wound (donor site) in a patient with poor wound-healing potential, and a lack of documented efficacy for the procedure. Epidermal grafting does not have some of the limitations encountered with STSG; however, it has not gained wide acceptance, as previous harvesting techniques were cumbersome and time-consuming. A novel automated epidermal harvesting system, CelluTome Epidermal Harvesting System (KCI, an Acelity company, San Antonio, TX, USA), was commercially introduced in 2013. The system yields up to 128 epidermal micrografts that can be easily harvested at the bedside without anaesthesia and transferred to the recipient site. The harvesting technique and the use of epidermal grafts in wounds are reviewed here.
C1 SerenaGrp, Cambridge, MA 02140 USA.
RP Serena, TE (通讯作者)，SerenaGrp, Cambridge, MA 02140 USA.
EM serene@serenagroups.com
FU KCI, an Acelity company, Edinburgh, Scotland
FX TES presented as a faculty member during the 2014 International Surgical
   Wound Forum (ISWF), an annual educational event sponsored by KCI, an
   Acelity company, held in 2014 in Edinburgh, Scotland. His article is
   part of a KCI-funded educational supplement based on faculty
   presentations at the 2014 ISWF session related to wound care strategies
   using epidermal micrografts. Acelity provided editorial assistance. TES
   is a consultant for KCI, an Aceilty company.
CR [Anonymous], ADV SKIN WOUND CARE
   [Anonymous], PODIATRY MANAGE
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NR 19
TC 14
Z9 18
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2015
VL 24
IS 4
SU S
BP 30
EP 34
DI 10.12968/jowc.2015.24.Sup4b.30
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG1YK
UT WOS:000353071900005
PM 25853646
DA 2026-07-24
ER

PT J
AU Reyzelman, AM
   Bazarov, I
AF Reyzelman, Alexander M.
   Bazarov, Irina
TI Initial Clinical Assessment of a Novel Multifunctional Topical Ointment
   for Difficult-to-Heal Wounds: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE chronic wounds; wound healing; topical healing ointments
AB Chronic wounds are characterized by prolonged inflammation, bacterial bioburden, and ischemia. These factors represent the barriers to wound healing that need to be addressed in order to achieve wound closure. The authors performed the initial clinical testing of WinVivo Wound Ointment ("WinVivo''), a novel topical ointment containing several botanicals that have been previously shown to promote favorable wound environment and advance wound healing. In this series of 13 patients with difficult-to-heal lower-extremity wounds, WinVivo was well tolerated and demonstrated the ability to simultaneously support granulation tissue formation; decrease the amount of exudate, edema, and malodor; and reduce pain. The ulcers included in this study have been present for a minimum of 3 weeks and a maximum of 5 years prior to the start of treatment with WinVivo. Eight of 13 wounds have previously been treated with at least 1 type of advanced wound healing modality, such as dermal substitutes or negative-pressure wound therapy. Treatment with WinVivo lasted for 3 to 12 weeks and resulted in a mean 88% wound closure, with 4 wounds healing completely. In addition to significant reduction in wound size, all patients have exhibited other clinical benefits, suggesting overall improvement in wound conditions. Future studies in a larger population, as well as case-control studies comparing WinVivo with a standard of care, are therefore warranted to further evaluate the efficacy of this new treatment.
C1 [Reyzelman, Alexander M.] Samuel Merritt Univ, Calif Sch Podiatr Med, Dept Med, Oakland, CA USA.
C3 Samuel Merritt University
RP Reyzelman, AM (通讯作者)，Samuel Merritt Univ, Calif Sch Podiatr Med, Dept Med, Oakland, CA USA.
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NR 10
TC 1
Z9 1
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD DEC
PY 2012
VL 25
IS 12
BP 557
EP 560
DI 10.1097/01.ASW.0000423441.00908.05
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 039HN
UT WOS:000311235500005
PM 23151766
DA 2026-07-24
ER

PT J
AU Ramser, M
   Glauser, PM
   Glass, TR
   Weixler, B
   Grapow, MTR
   Hoffmann, H
   Kirchhoff, P
AF Ramser, Michaela
   Glauser, Philippe M.
   Glass, Tracy R.
   Weixler, Benjamin
   Grapow, Martin T. R.
   Hoffmann, Henry
   Kirchhoff, Philipp
TI Abdominal Decompression after Cardiac Surgery: Outcome of 42 Patients
   with Abdominal Compartment Syndrome
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
AB Background Up to 50% of patients in intensive care units develop intraabdominal hypertension (IAH) in the course of medical treatment. If not detected on time and treated adequately, IAH may develop into an abdominal compartment syndrome (ACS) which is associated with a high mortality rate. Patients undergoing cardiac surgery are especially prone to develop ACS due to several risk factors including intraoperative hypothermia, fluid resuscitation and acidosis. We investigated patients who developed ACS after cardiac surgery and analyzed potential risk factors, treatment and outcome. Methods From 2011 to 2016, patients with ACS after cardiac surgery requiring decompressive laparotomy were prospectively recorded. Patient characteristics, details on the cardiac surgery, mortality rate and type of treatment of the open abdomen were analyzed. Results Incidence of ACS in cardiac surgery patients was 1.0% (n = 42/4128), with a mortality rate of 57%. Ejection fraction, Euroscore2 as well as the perfusion time are independent risk factors for the development of ACS. The outcome of patients with ACS was independent of elective versus emergency surgery, gender, age, BMI or ASA score. In the 18 surviving patients, fascial closure was achieved in 72% after a median of 9 days. Conclusion Abdominal compartment syndrome is a rare but serious complication after cardiac surgery with a high mortality rate. Independent risk factors for ACS were identified. Negative pressure wound therapy seems to promote and allow early fascia closure of the abdomen and represents therefore a likely benefit for the patient.
C1 [Ramser, Michaela; Glauser, Philippe M.] Univ Hosp Basel, Dept Surg, Basel, Switzerland.
   [Ramser, Michaela] Kantonsspital Olten, Solothurner Spitaler, Dept Surg, Olten, Switzerland.
   [Glauser, Philippe M.] Spital Dornach, Solothurner Spitaler, Dept Surg, Dornach, Switzerland.
   [Glass, Tracy R.] Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
   [Glass, Tracy R.; Weixler, Benjamin; Hoffmann, Henry; Kirchhoff, Philipp] Univ Basel, Basel, Switzerland.
   [Weixler, Benjamin] Charite, Dept Surg, Berlin, Germany.
   [Grapow, Martin T. R.] Univ Hosp Basel, Dept Cardiac Surg, Basel, Switzerland.
   [Grapow, Martin T. R.] HerzZentrum, Hirslanden Klin Zurich, Zurich, Switzerland.
   [Hoffmann, Henry; Kirchhoff, Philipp] ZweiChirurgen, Ctr Hernia Surg & Proctol, Basel, Switzerland.
C3 University of Basel; Kantonsspital Olten; Swiss School of Public Health
   (SSPH+); University of Basel; Swiss Tropical & Public Health Institute;
   University of Basel; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; University of Basel
RP Ramser, M (通讯作者)，Univ Hosp Basel, Dept Surg, Basel, Switzerland.; Ramser, M (通讯作者)，Kantonsspital Olten, Solothurner Spitaler, Dept Surg, Olten, Switzerland.
EM michaela.ramser@spital.so.ch
RI ; Glass, Tracy/D-5046-2017
OI Raer, Michaela/0000-0002-3139-1898; Grapow, Martin/0000-0001-6316-0691;
   Glass, Tracy/0000-0001-7075-9803
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NR 50
TC 9
Z9 10
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2021
VL 45
IS 4
BP 1242
EP 1251
DI 10.1007/s00268-020-05917-0
EA JAN 2021
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QP8DO
UT WOS:000609979600005
PM 33481080
DA 2026-07-24
ER

PT J
AU Swanson, T
   Lázaro-Martínez, JL
   Braumann, C
   Kirchhoff, JB
   Gächter, B
   van Acker, K
AF Swanson, Torry
   Lazaro-Martinez, Jose Luis
   Braumann, Chris
   Kirchhoff, Jan-Birger
   Gaechter, Bernd
   van Acker, Kristian
TI Ultrasonic-assisted wound debridement: report from a closed panel
   meeting
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Sequential ultrasonic-assisted debridement; bacterial load;
   implementation; barriers
ID LOW-FREQUENCY ULTRASOUND; NEOVASCULARIZATION; THERAPY
AB Mechanical debridement can be considered as an alternative to surgical debridement if surgery is not available, or is considered impractical or too high risk. One form of selective mechanical debridement is ultrasonic-assisted wound (UAW) debridement. As the published evidence on this is limited, a closed international expert meeting was held to review the existing evidence base on it, present preliminary findings of research currently in progress and discuss individual cases selected from the clinical experts' own practice. The panel also explored the potential barriers to the implementation of UAW debridement and how these might be addressed. It concluded there is sufficient evidence that UAW debridement is an effective method of cleansing and debriding almost all hard-to-heal wounds. Patients who are most likely to benefit from it are not medically stable, on anticoagulants, unable to visit a hospital for wound treatment, and/or have wounds with a poor vascular supply or are close to critical structures. The panel also observed that UAW debridement can be used to prepare the wound for negative pressure wound therapy (NPWT) or as an adjunctive to it. Given the potential to experience pain during the procedure, the panel considered that patients will benefit from topical analgesia. The panel noted that health professionals, patients and visitors must be protected from the aerosolisation associated with UAW, to reduce risk of cross-contamination.
C1 [Lazaro-Martinez, Jose Luis] Univ Complutense Madrid, Diabet Foot Unit, Madrid, Spain.
   [Braumann, Chris] Ruhr Univ Bochum, St Josef Hosp, Bochum, Germany.
   [Kirchhoff, Jan-Birger] Raphaelsklin Munster, Munster, Germany.
   [Gaechter, Bernd] Hosp Oberengadin, Clin Gen Trauma & Visceral Surg, Samedan, Switzerland.
   [Gaechter, Bernd] Wound Care Ctr, Minusio Bellinzona, Ticino, Switzerland.
   [van Acker, Kristian] D Foot Int, CSF, Dept Diabetol & Endocrinol, Chimay, Belgium.
C3 Complutense University of Madrid; Ruhr University Bochum
EM swansonterry7@gmail.com
RI LAZARO MARTINEZ, JOSE LUIS/AAE-2268-2021
OI LAZARO MARTINEZ, JOSE LUIS/0000-0001-6110-0265
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   Shannon MK, 2012, WOUND PRACT RES, V20, P200
   Stanisic Margaret McCarty, 2005, Adv Skin Wound Care, V18, P484
   Strohal R, 2013, J WOUND CARE, V22, P5
   Voigt J, 2011, INT J LOW EXTR WOUND, V10, P190, DOI 10.1177/1534734611424648
   Wang D, 2008, BIOTECH HISTOCHEM, V83, P179, DOI 10.1080/10520290802451085
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   Wolcott R D, 2009, J Wound Care, V18, P54
   Wollina Uwe, 2005, Int J Low Extrem Wounds, V4, P214, DOI 10.1177/1534734605283001
NR 29
TC 11
Z9 15
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2020
VL 29
IS 2
BP 128
EP 135
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KK8TX
UT WOS:000513010100006
PM 32058848
DA 2026-07-24
ER

PT J
AU Tedesco, S
   Di Grezia, M
   Tropeano, G
   Altieri, G
   Brisinda, G
AF Tedesco, Silvia
   Di Grezia, Marta
   Tropeano, Giuseppe
   Altieri, Gaia
   Brisinda, Giuseppe
TI Necrotizing soft tissue infections: a surgical narrative review
SO UPDATES IN SURGERY
LA English
DT Review
DE Humans; Soft tissue infections/therapy/diagnosis; Debridement;
   Anti-bacterial agents/therapeutic use; Necrosis; Fasciitis,
   Necrotizing/therapy/diagnosis; Negative pressure wound therapy
ID INTENSIVE-CARE; FASCIITIS; MORTALITY; SKIN; MULTICENTER; MANAGEMENT;
   DEBRIDEMENT; DIAGNOSIS; OUTCOMES
AB Necrotizing soft tissue infections represent a spectrum of diseases characterized by extensive necrosis involving the skin, subcutaneous tissues, fascia or muscles. These infections are generally severe and rapidly progressive, often accompanied by sepsis, septic chock, multiple organ failure and, ultimately, death. Several classifications have been developed based on multiple parameters, such as the anatomical location of the disease, the depth of the lesion or the microbiology. Numerous clinical factors predispose individuals to the development of necrotizing soft tissue infections. The clinical presentation is not always characterized by local signs and systemic symptoms of infection, which can lead to delays in both diagnosis ad treatment. Broad-spectrum antibiotic directed at the likely organisms is essential early in the treatment course, but do not substitute surgical management. Antibiotic therapy should be subsequently tailored to the etiologic micro-organism. Rapid recognition and early surgical intervention form the mainstay of management of necrotizing soft tissue infections. Initial surgical debridement should be promptly performed preferably at the presenting hospital, when adequate infrastructure and personnel are available. Transfer to a referral center may be necessary for definitive surgical and complex wound care. Most patients require more than one debridement. A multidisciplinary approach is also essential to improve the results in the treatment of these patients.
C1 [Tedesco, Silvia; Di Grezia, Marta; Tropeano, Giuseppe; Altieri, Gaia; Brisinda, Giuseppe] Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Med & Surg Sci, IRCS, I-00168 Rome, Italy.
   [Brisinda, Giuseppe] Agostino Gemelli, Catholic Sch Med, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Brisinda, G (通讯作者)，Fdn Policlin Univ A Gemelli, Emergency Surg & Trauma Ctr, Dept Med & Surg Sci, IRCS, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，Agostino Gemelli, Catholic Sch Med, I-00168 Rome, Italy.
EM giuseppe.brisinda@policlinicogemelli.it
RI ; Brisinda, Giuseppe/G-6436-2010
OI Tedesco, Silvia/0000-0003-4693-4725; Tropeano,
   Giuseppe/0000-0001-9006-5040; Brisinda, Giuseppe/0000-0001-8820-9471
FU Universita Cattolica del Sacro Cuore within the CRUI-CARE Agreement
FX Open access funding provided by Universita Cattolica del Sacro Cuore
   within the CRUI-CARE Agreement. This research did not receive any
   specific grant from funding agencies in the public, commercial, or
   not-for-profit sectors.
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NR 70
TC 17
Z9 21
U1 2
U2 5
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD AUG
PY 2025
VL 77
IS 4
BP 1239
EP 1251
DI 10.1007/s13304-025-02222-0
EA APR 2025
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4YC9K
UT WOS:001477766400001
PM 40295449
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lukish, J
   Stewart, D
   Goldstein, S
   Garcia, A
   Pryor, H
   Rhee, D
   Alaish, S
   Colombani, P
AF Lukish, Jeffrey
   Stewart, Dylan
   Goldstein, Seth
   Garcia, Alejandro
   Pryor, Howard
   Rhee, Daniel
   Alaish, Samuel
   Colombani, Paul
TI Microdeformational wound therapy: A novel option to salvage complex
   wounds associated with the Nuss procedure
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article
DE Pectus excavatum; Negative pressure wound therapy; PICO vac
ID COMPLICATIONS; INFECTION; SURGERY; DEVICE
AB Background: Complex wounds associated with the Nuss procedure are a resource intensive complication that may lead to significant morbidity with potential removal of the implanted device and abandonment of the repair. We report our management technique of this complication utilizing microdeformational wound therapy (MDWT) that is safe, is efficacious and allows for salvage of the repair.
   Operative technique: We defined a complex wound as a wound that became suppurative and drained in the post-operative period and failed to resolve with a trial of conventional wound management and antibiotics. Upon recognition of a complex wound, we recommend an initial operative wound debridement. This allows wound cultures, wound assessment and precise initiation of MDWT. It is not uncommon to have exposed hardware in the wound early in the course of therapy. Metal allergy must be excluded. The patient is transitioned to oral antibiotics following resolution of the acute process. MDWT is performed until the wounds are completely epithelialized with no clinical signs of drainage or infection. The average length of MDWT in our patients was 39 days. Following complete wound healing the patients are maintained on antibiotics until implant removal.
   Conclusions: The use of microdeformational wound therapy in complex wounds associated with the Nuss procedure is a safe and effective modality. The technique may reduce the likelihood of implant removal with potential recurrent pectus excavatum.
   Type of study: Operative technique. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Lukish, Jeffrey; Pryor, Howard] Childrens Natl Med Ctr, Div Pediat Surg, Washington, DC 20010 USA.
   [Lukish, Jeffrey; Pryor, Howard] Uniformed Serv Univ Hlth Sci, Div Pediat Surg, Bethesda, MD 20814 USA.
   [Stewart, Dylan; Goldstein, Seth; Garcia, Alejandro; Pryor, Howard; Rhee, Daniel; Alaish, Samuel; Colombani, Paul] Johns Hopkins Univ, Div Pediat Surg, Baltimore, MD USA.
   [Colombani, Paul] Johns Hopkins All Childrens Hosp St, Div Pediat Surg, St Petersburg, FL USA.
C3 Children's National Health System; Uniformed Services University of the
   Health Sciences - USA; Johns Hopkins University; Johns Hopkins
   University; Johns Hopkins Medicine
RP Lukish, J (通讯作者)，Childrens Natl Med Ctr, 111 Michigan Ave NW, Washington, DC 20010 USA.
EM jlukish@childrensnational.org
OI Alaish, Samuel/0000-0002-8021-3609; Goldstein, Seth/0000-0001-7806-4109;
   Pryor, Howard/0000-0001-8475-5619
CR AAP Section on Surgery; AAP Committee on Bioethics; AAP American Pediatric Surgical Association New Technology Committee, 2017, PEDIATRICS, V139
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NR 20
TC 1
Z9 1
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD JUL
PY 2019
VL 54
IS 7
BP 1500
EP 1504
DI 10.1016/j.jpedsurg.2019.03.006
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA IE6RD
UT WOS:000472502500041
PM 30967247
DA 2026-07-24
ER

PT J
AU Schlüer, AB
   Schols, JMGA
   Halfens, RJG
AF Schlueer, Anna-Barbara
   Schols, Jos M. G. A.
   Halfens, Ruud J. G.
TI Pressure Ulcer Treatment in Pediatric Patients
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE pressure ulcer; pediatric nursing; wound care in pediatrics;
   negative-pressure wound therapy
ID SKIN; WOUNDS; PREVALENCE; MANAGEMENT; THERAPY; ADULT; FLAP
AB OBJECTIVE: To assess pressure ulcer (PrU) treatment in Swiss hospitalized pediatric patients and to determine whether there are differences in PrU treatment, according to demographic characteristics of the patients.
   DESIGN: A descriptive multicenter point prevalence study was conducted in June 2009 in all German-speaking pediatric hospitals in Switzerland.
   SETTING: All hospitalized patients from birth up to 17 years or younger in 14 Swiss pediatric hospitals, including all pediatric departments, were assessed.
   PATIENTS: A total of 412 patients participated in this study.
   MAIN OUTCOME MEASURES: The instrument and method of the Dutch National Prevalence Measurement of Care Problems were used.
   MAIN RESULTS: Thirty-five percent of the patients had a PrU. Almost all of these PrUs (94.1%) were of category 1. The most severe PrUs occurred in patients older than 8 years. Age of the patient and department were the only characteristics that significantly influenced the occurrence of PrU categories 2 to 4. Pressure ulcer categories 2 to 4 were mostly covered with hydrocolloid or polyurethane foam dressings. No pediatric-specific guideline regarding PrU treatment is used in the involved hospitals.
   CONCLUSION: Most patients had category 1 PrUs, so appropriate prevention to decrease any further trauma in these patients was necessary. Severe PrUs (categories 2-4) are mostly limited to older pediatric (aged 98 years) patients with chronic conditions or after surgery intervention. A PrU treatment guideline adapted for pediatric needs is recommended.
C1 [Schlueer, Anna-Barbara] Univ Childrens Hosp Zurich, Dept Nursing Dev & Sci, Zurich, Switzerland.
   [Schlueer, Anna-Barbara] Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland.
   [Schols, Jos M. G. A.] CAPHRI Maastricht Univ, Dept Family Med, Maastricht, Netherlands.
   [Schols, Jos M. G. A.] CAPHRI Maastricht Univ, Dept Hlth Serv Res, Maastricht, Netherlands.
   [Halfens, Ruud J. G.] CAPHRI Maastricht Univ, Dept Hlth Serv Res, Maastricht, Netherlands.
C3 University Children's Hospital Zurich; University Children's Hospital
   Zurich; Maastricht University; Maastricht University; Maastricht
   University
RP Schlüer, AB (通讯作者)，Univ Childrens Hosp Zurich, Dept Nursing Dev & Sci, Zurich, Switzerland.
OI Schlüer, Anna-Barbara/0000-0003-1046-3650
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NR 44
TC 17
Z9 19
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2013
VL 26
IS 11
BP 504
EP 510
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 298TF
UT WOS:000330346700005
PM 24149665
DA 2026-07-24
ER

PT J
AU Lavery, LA
   Seaman, JW
   Barnes, SA
   Armstrong, DG
   Keith, MS
AF Lavery, Lawrence A.
   Seaman, John W., Jr.
   Barnes, Sunni A.
   Armstrong, David G.
   Keith, Michael S.
TI Prediction of healing for postoperative diabetic foot wounds based on
   early wound area progression
SO DIABETES CARE
LA English
DT Article
ID ULCERS; DRESSINGS; TRIAL
AB OBJECTIVE - To evaluate the probability of wound healing based on percentage of wound area reduction (PWAR) at 1 and 4 weeks in individuals with large, chronic, nonischemic diabetic foot wounds following partial foot amputation.
   METHODS - Data from a 16-week randomized clinical trial (RCT) of 162 patients were analyzed to compare outcomes associated with negative-pressure wound therapy (NPWT) delivered through the V.A.C. Therapy System (Kinetic Concepts, San Antonio, TX) (n = 77) versus standard moist wound therapy (MWT) (n = 85). The 1- and 4-week regression models included 153 and 129 of the RCT patients, respectively.
   RESULTS - Early changes in PWAR were predictive of final healing at 16 weeks. Specifically, wounds that reached >= 15% PWAR at 1 week or >= 60% PWAR at 4 weeks had a 68 and 77% (respectively) probability of healing vs. a 31 and 30% probability if these wound area reductions were not achieved. Patients receiving NPWT were 2.5 times more likely to achieve both a >= 15% PWAR at 1 week and a 60% area reduction at 1 month (odds ratios 2.51 and 2.49, respectively) compared with those receiving MWT.
   CONCLUSION - Results of this study suggest that clinicians can calculate: the PWAR of a wound as early as 1 week into treatment to predict the likelihood of healing at 16 weeks. This might also assist in identifying a rationale to reevaluate the wound and change wound therapies.
C1 [Lavery, Lawrence A.] Texas A&M Univ, Scott & White Mem Hosp, Dept Surg, Georgetown, TX 77843 USA.
   [Barnes, Sunni A.; Keith, Michael S.] Kinet Concepts Inc, Hlth Outcomes Res, San Antonio, TX USA.
   [Seaman, John W., Jr.] Baylor Univ, Dept Stat Sci, Waco, TX 76798 USA.
   [Armstrong, David G.] Rosalind Franklin Univ Med & Sci, Dr William M Sch Coll Podiat Med, N Chicago, IL USA.
C3 Texas A&M University System; Scott & White Medical Center; Baylor
   University; Rosalind Franklin University of Medicine & Science
RP Lavery, LA (通讯作者)，Texas A&M Hlth Sci Ctr, Scott & White Georgetown Clin, 703 Highland Spring Ln, Georgetown, TX 78628 USA.
EM lklavery@yahoo.com
OI Lavery, Lawrence/0000-0002-7920-9952
CR [Anonymous], 1999, WINBUGS VERSION 1 2
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NR 12
TC 112
Z9 121
U1 1
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JAN
PY 2008
VL 31
IS 1
BP 26
EP 29
DI 10.2337/dc07-1300
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 248TQ
UT WOS:000252178900006
PM 17934156
OA Bronze
DA 2026-07-24
ER

PT J
AU Yang, CL
   Wang, DL
AF Yang, Chenglan
   Wang, Dali
TI Antibiotic bone cement accelerates diabetic foot wound healing:
   Elucidating the role of ROCK1 protein expression
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE antibiotic bone cement; diabetic foot; negative pressure wound therapy;
   ROCK1; wound healing
ID INDUCED MEMBRANE; RHO-KINASE; ULCERS; THERAPY; MASQUELET; DISEASE; CELL
AB Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure. Wound healing rate, amputation rate, wound secretion culture and C-reactive protein (CRP) changes, were monitored. Comprehensive molecular investigations were conducted and animal experiments were performed to further validate the findings. Statistical methods were employed to verify significant differences between the groups and treatment outcomes. The EXP group showed significant improvements in wound healing (chi(2)= 11.265, p = 0.004) and reduced amputation rates. Elevated levels of ROCK1, fibroblasts and VGF were observed in the trauma tissue post-treatment in the experimental group compared to pre-treatment and the control group (all p < 0.05). Improved trauma secretion culture and CRP were also noted in the EXP group (all p < 0.05). The study suggests that antibiotic bone cement enhances diabetic foot wound healing, possibly via upregulation of ROCK1. Further research is needed to elucidate the underlying molecular mechanisms and broader clinical implications.
C1 [Yang, Chenglan] Soochow Univ, Sch Med, Suzhou, Jiangsu, Peoples R China.
   [Wang, Dali] Zunyi Med Univ, Dept Burn Plast Surg, Affiliated Hosp, Zunyi 563000, Guizhou, Peoples R China.
C3 Soochow University - China; Zunyi Medical University
RP Wang, DL (通讯作者)，Zunyi Med Univ, Dept Burn Plast Surg, Affiliated Hosp, Zunyi 563000, Guizhou, Peoples R China.
EM daliwangzy@sina.com
FU Collaborative Innovation Center of Chinese Ministry of Education
FX We extend our deepest gratitude towards our colleagues who have
   contributed to this work and Papergoing institution for their
   contribution in manuscript polishing.
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NR 36
TC 7
Z9 8
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 26
PY 2024
VL 21
IS 4
AR e14590
DI 10.1111/iwj.14590
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA MF2O7
UT WOS:001192148600001
PM 38531354
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Iwasaki, R
   Motomura, H
   Hatano, T
   Sakahara, D
   Fujii, N
AF Iwasaki, Rie
   Motomura, Hisashi
   Hatano, Takaharu
   Sakahara, Daisuke
   Fujii, Naho
TI Reconstruction of Pelvic Exenteration Defects Using the Combined Method
   With Extended Vertical Rectus Abdominus Flap and Vacuum- Assisted
   Suction Drainage
SO INTERNATIONAL SURGERY
LA English
DT Article
DE Reconstruction; Rectus abdominus flap; Suction drain; Negative pressure
   wound therapy (NPWT)
ID THERAPY; FLOOR
AB Introduction: Pelvic exenteration is a highly invasive procedure, with a reported rate of 20%-80% for serious complications. Thus, the prevention of postoperative complications is a major issue. Many previous reports have emphasized the importance of filling the dead space to prevent postoperative complications. In addition to filling the dead space, we believe that achieving sufficient drainage is extremely important. In this paper, we present a new combined method of the extended rectus abdominis myocutaneous flap and vacuum drainage with multiple drains, which achieved a lower frequency of complications.
   Case Presentation: The subjects were 6 patients who underwent reconstruction following pelvic exenteration during a 7-year period between April 2005 and September 2013. We retrospectively measured the volume of the pelvic cavity and that of the rectus abdominis flap on lateral computed tomography (CT) scans to calculate the percentage of the dead space that was filled by the flap. There were no problems with flap engraftment in any of the patients. There were no serious complications, and no patient required additional surgery. The percentage of the dead space filled ranged from 25% to 46% (mean: 32%).
   Conclusion: The rectus flap + vacuum drainage method, which uses an extended rectus abdominis myocutaneous flap to decrease the pelvic dead space and multiple vacuum suction drains, was associated with the prevention of serious complications.
C1 [Iwasaki, Rie; Motomura, Hisashi; Hatano, Takaharu; Sakahara, Daisuke; Fujii, Naho] Osaka City Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, Osaka, Japan.
C3 Osaka Metropolitan University
RP Motomura, H (通讯作者)，Osaka City Univ, Dept Plast & Reconstruct Surg, Grad Sch Med, Abeno Ku, Asahi 1-4-3, Osaka 5458585, Japan.
EM motomura@med.osaka-cu.ac.jp
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Z9 2
U1 0
U2 1
PU INT COLLEGE OF SURGEONS
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PA 1516 N LAKE SHORE DR, CHICAGO, IL 60610 USA
SN 0020-8868
J9 INT SURG
JI Int. Surg.
PD MAR-APR
PY 2019
VL 104
IS 3-4
BP 138
EP 142
DI 10.9738/INTSURG-D-17-00105.1
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NC6XC
UT WOS:000561359300009
OA gold
DA 2026-07-24
ER

PT J
AU Jones, CM
   Rothermel, AT
   Mackay, DR
AF Jones, Christine M.
   Rothermel, Alexis T.
   Mackay, Donald R.
TI Evidence-Based Medicine: Wound Management
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID DIABETIC FOOT ULCERS; PERIOPERATIVE GLUCOSE MANAGEMENT; PRESSURE
   PULSATILE LAVAGE; HYPERBARIC-OXYGEN THERAPY; RANDOMIZED CLINICAL-TRIAL;
   SURGICAL SITE INFECTION; NEOADJUVANT CHEMOTHERAPY; MARJOLINS ULCER;
   RISK-FACTORS; POSTOPERATIVE COMPLICATIONS
AB Learning Objectives: After reading this article, the participant should be able to: 1. Describe the basic science of chronic wounds. 2. Discuss the general and local factors that should be considered in any patient with a chronic wound. 3. Discuss the rationale of converting a chronic wound into an acute wound. 4. Describe techniques used to prepare chronic wounds. 5. Discuss the appropriate use of different dressings presented in this article. 6. Discuss the pros and cons of the adjuncts to wound healing discussed in this article.
   Summary: This is the second Maintenance of Certification article on wound healing. In the first, Buchanan, Kung, and Cederna dealt with the mechanism and reconstructive techniques for closing wounds. In this article, the authors have concentrated on the chronic wound. The authors present a summary of the basic science of chronic wounds and the general and local clinical factors important in assessing any chronic wound. The evidence for interventions of these conditions is presented. The surgical and nonsurgical methods of wound preparation and the evidence supporting the use of the popular wound dressings are presented. The authors then present the evidence for some of the popular adjuncts for wound healing, including hyperbaric oxygen, electrotherapy, and ultrasound. A number of excellent articles on negative-pressure wound therapy have been written, and are not covered in this article.
C1 [Jones, Christine M.; Rothermel, Alexis T.; Mackay, Donald R.] Penn State Hershey Med Ctr, Div Plast Surg, 500 Univ Dr Mail Code H071, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Mackay, DR (通讯作者)，Penn State Hershey Med Ctr, Div Plast Surg, 500 Univ Dr Mail Code H071, Hershey, PA 17033 USA.
EM dmackay@hmc.psu.edu
RI Mackay, Donald/AEE-0970-2022
OI Mackay, Donald/0000-0003-3952-1527; Jones, Christine/0000-0002-6333-8039
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NR 187
TC 23
Z9 29
U1 1
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUL
PY 2017
VL 140
IS 1
BP 201E
EP 216E
DI 10.1097/PRS.0000000000003486
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EZ4XY
UT WOS:000404717000022
PM 28654620
DA 2026-07-24
ER

PT J
AU Qian, SQ
   Gao, L
   Wei, Q
   Yuan, JH
AF Qian, Sheng-Qiang
   Gao, Liang
   Wei, Qiang
   Yuan, Jiuhong
TI Vacuum therapy in penile rehabilitation after radical prostatectomy:
   review of hemodynamic and antihypoxic evidence
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
DE oxygen; penile rehabilitation; tissue perfusion; vacuum erectile device
ID PRESSURE WOUND THERAPY; TOPICAL NEGATIVE-PRESSURE; ERECTILE DYSFUNCTION;
   BLOOD-FLOW; ASSISTED CLOSURE; DEVICE; RECOVERY; MECHANISMS; SCIENCE;
   TENSION
AB Generally, hypoxia is a normal physiological condition in the flaccid penis, which is interrupted by regular nocturnal erections in men with normal erectile function. 1 Lack of spontaneous and nocturnal erections after radical prostatectomy due to neuropraxia results in persistent hypoxia of cavernosal tissue, which leads to apoptosis and degeneration of cavernosal smooth muscle fibers. Therefore, overcoming hypoxia is believed to play a crucial role during neuropraxia. The use of a vacuum erectile device (VED) in penile rehabilitation is reportedly effective and may prevent loss of penile length. The corporal blood after VED use is increased and consists of both arterial and venous blood, as revealed by color Doppler sonography and blood gas analysis. A similar phenomenon was observed in negative pressure wound therapy (NPWT). However, NPWT employs a lower negative pressure than VED, and a hypoperfused zone, which increases in response to negative pressure adjacent to the wound edge, was observed. Nonetheless, questions regarding ideal subatmospheric pressure levels, modes of action, and therapeutic duration of VED remain unanswered. Moreover, it remains unclear whether a hypoperfused zone or PO2 gradient appears in the penis during VED therapy. To optimize a clinical VED protocol in penile rehabilitation, further research on the mechanism of VED, especially real-time PO2 measurements in different parts of the penis, should be performed.
C1 [Qian, Sheng-Qiang; Gao, Liang; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Androl Lab, Chengdu 610041, Peoples R China.
   [Qian, Sheng-Qiang; Gao, Liang; Wei, Qiang; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University
RP Yuan, JH (通讯作者)，Sichuan Univ, West China Hosp, Androl Lab, Chengdu 610041, Peoples R China.; Yuan, JH (通讯作者)，Sichuan Univ, West China Hosp, Dept Urol, Chengdu 610041, Peoples R China.
EM jiuhongyuan2107@163.com
OI Yuan, Jiuhong/0000-0002-0991-1463
FU Natural Science Foundation of China [81170565]
FX This work was supported by the Natural Science Foundation of China (No.
   81170565).
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U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD MAY-JUN
PY 2016
VL 18
IS 3
BP 446
EP 451
DI 10.4103/1008-682X.159716
PG 6
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA DK4AE
UT WOS:000374857800032
PM 26289397
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mukhopadhaya, J
   Bhadani, JS
   Kumar, R
   Singh, J
   Vaishya, R
AF Mukhopadhaya, John
   Bhadani, Janki Sharan
   Kumar, Raju
   Singh, Jaswinder
   Vaishya, Raju
TI Functional Outcome of Intraarticular Osteotomy and Osteosynthesis for
   Calcaneal Malunion with Salvageable Subtalar Joint: A Retrospective Case
   Series
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Calcaneal malunion; Calcaneal fracture; Intraarticular osteotomy;
   Subtalar joint preservation; Maryland foot score; AOFAS ankle-hindfoot
   score
ID FRACTURE; ARTHRODESIS; MANAGEMENT; FUSION
AB Background and ObjectiveCalcaneal malunion, a frequent complication of calcaneal fractures, disrupts hindfoot anatomy, causing pain, deformity, stiffness, and gait abnormalities. While conservative management can be effective in selected cases, surgical intervention is often required. This study evaluates the efficacy of intraarticular osteotomy and osteosynthesis as a joint-preserving procedure to manage calcaneal malunion and prevent subtalar arthrodesis.MethodsA retrospective analysis was conducted on ten male patients (aged 23-52 years) with symptomatic calcaneal malunion who underwent intraarticular osteotomy and osteosynthesis between March 2015 and March 2023. Functional outcomes were assessed using the Maryland Foot Score (MFS) and the American Orthopaedic Foot & Ankle Society (AOFAS) score. Clinical, radiological, and procedural parameters were analyzed.ResultsThe average follow-up duration was 42.9 months (range 15-108 months). Type II malunion (60%) was the most common. Postoperative functional outcomes showed improvement, with a mean MFS of 92.4 and an AOFAS score of 84. Wound breakdown primarily in diabetic patients, was managed successfully with negative pressure wound therapy. Significant enhancements in radiological alignment and functional parameters were observed in all patients.ConclusionIntraarticular osteotomy and osteosynthesis are effective surgical options for managing calcaneal malunion, facilitating subtalar joint preservation and obviating the need for subtalar arthrodesis. This procedure optimizes functional recovery and preserves joint mobility in carefully selected patients.
C1 [Mukhopadhaya, John; Bhadani, Janki Sharan; Kumar, Raju; Singh, Jaswinder] Paras HMRI Hosp, Dept Orthopaed, Patna 800014, Bihar, India.
   [Vaishya, Raju] Indraprastha Apollo Hosp, Dept Orthopaed, New Delhi, India.
RP Bhadani, JS (通讯作者)，Paras HMRI Hosp, Dept Orthopaed, Patna 800014, Bihar, India.
EM mukhoj@gmail.com; jsbhadani@gmail.com; drrajukumarortho@gmail.com;
   hijaswinderin@yahoo.com; raju.vaishya@gmail.com
RI Bhadani, Janki Sharan/AEM-1955-2022; VAISHYA, RAJU/I-3726-2015
OI Bhadani, Janki Sharan/0000-0002-3329-8355; VAISHYA,
   RAJU/0000-0002-9577-9533
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   Zhang T, 2020, ORTHOP SURG, V12, P827, DOI 10.1111/os.12686
NR 33
TC 0
Z9 1
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD MAY
PY 2025
VL 59
IS 5
BP 591
EP 601
DI 10.1007/s43465-025-01367-9
EA MAR 2025
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 2CO5U
UT WOS:001454436300001
PM 40321482
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Mijatovic, D
   Orehovec, SS
   Dapic, T
   Mijatovic, VV
   Mance, M
AF Mijatovic, Davor
   Orehovec, Sanda Smud
   Dapic, Tomislav
   Mijatovic, Vilena Vrbanovic
   Mance, Marko
TI Management of a Complex Lower Limb Open Fracture in a Teenage Patient: A
   Case Report
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case study; tibial fracture; adolescent; limb salvage; reconstructive
   surgical procedures
ID PEDIATRIC POPULATION; TIBIAL FRACTURES; CHILDREN
AB The challenges of managing Gustilo IIIB tibial fractures (ie, high energy trauma with a contaminated wound >10 cm in length, severe comminution ["crumbling"] or segmental fractures, and periosteal stripping) children are unique in part because no clear guidelines exist and the injuries may cause short-term and long-term complications. Repeated wound debridement and secondary reconstruction are required in approximately 20% of these cases in both adults and children. A 13-year-old girl presented with severe polytrauma including an open Gustilo type IIIB fracture of the left lower leg. The patient declined limb amputation; a multidisciplinary team (plastic, pediatric, orthopedic-trauma surgeons, pediatrician, psychiatrist, clinical pharmacologist, anesthesiologist, physiotherapist, nurses) was assembled in order to give the patient the best chance of a successful outcome. Multiple limb salvage and reconstructive procedures including wound debridements, necrectomies, long-term negative pressure wound therapy, soft tissue reconstructions, a external bone fixation, bone osteosynthesis, multiple skin grafts, and free-flap reconstruction were provided over a period of 6 months with great success. The patient is doing well 3 years after initial injury and is walking without , complications. A multidisciplinary approach and structured treatment plan are important to minimize complications, avoid necessary delays in app roach morbidity, and provide the patient with the best result possible. Studies examining optimal treatment treatment strategies for children and adolescents with these complicated fractures are needed.
C1 [Mijatovic, Davor] Univ Zagreb, Sch Med, Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
   [Mijatovic, Davor] Univ Hosp Ctr, Plast Reconstruct & Aesthet Surg Ward, Zagreb, Croatia.
   [Orehovec, Sanda Smud] Univ Hosp Ctr, Zagreb, Croatia.
   [Dapic, Tomislav] Univ Zagreb, Sch Med, Orthoped Surg, Zagreb, Croatia.
   [Dapic, Tomislav] Univ Hosp Ctr, Dept Orthopaed Surg, Zagreb, Croatia.
   [Mijatovic, Vilena Vrbanovic] Clin Hosp Ctr, Anesthesiol & Reanamatol, Dept Anesthesiol, Zagreb, Croatia.
   [Mance, Marko] Univ Hosp Ctr, Plast Reconstruct & Aesthet Surg, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   University of Zagreb; University of Zagreb; University of Zagreb
RP Orehovec, SS (通讯作者)，Clin Hosp Ctr, Dept Surg, Div Plast Reconstruct & Breast Surg, Kispaticeva 12, Zagreb 10000, Croatia.
EM sanda.smud@gmail.com
OI Vrbanović Mijatović, Vilena/0000-0001-8568-1359
CR Baldwin KD, 2009, J CHILD ORTHOP, V3, P199, DOI 10.1007/s11832-009-0169-6
   Bartlett CS, 1997, J ORTHOP TRAUMA, V11, P357, DOI 10.1097/00005131-199707000-00010
   Glass GE, 2009, INJURY, V40, P876, DOI 10.1016/j.injury.2008.12.010
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   Palmu SA, 2014, ACTA ORTHOP, V85, P513, DOI 10.3109/17453674.2014.916489
   Ruedi T, 2007, AO PRINCIPLES FRACTU, V1, P96
   Setter KJ, 2006, CURR OPIN PEDIATR, V18, P30, DOI 10.1097/01.mop.0001110936.81101.c3
NR 11
TC 2
Z9 2
U1 0
U2 10
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2018
VL 64
IS 5
BP 47
EP 52
DI 10.25270/owm.2018.5.4752
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GQ6XD
UT WOS:000441871700007
PM 29847311
DA 2026-07-24
ER

PT J
AU Mancino, AT
   Acott, A
   Brinegar, KP
AF Mancino, Anne T.
   Acott, Alison
   Brinegar, Kathryn P.
TI Injection of Cryopreserved Amniotic Membrane and Umbilical Cord
   Particulate for Pressure Injuries: A Retrospective Case Series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE amniotic membrane and umbilical cord; negative pressure wound therapy;
   particulate human placental tissue; pressure injury
ID QUALITY-OF-LIFE; SINGLE-CENTER; ULCERS; APOPTOSIS; MACROPHAGES;
   NEUTROPHILS; ACTIVATION; EXPRESSION; KERATITIS; IMPACT
AB Introduction. PI poses a significant burden to society. Cryopreserved AMUC has potential benefits in managing complex wounds owing to its anti-inflammatory, anti-scarring, and proregenerative properties. AMUC grafts are commonly in sheets, but also come as morselized powders that can be sprinkled or injected. The authors initially used AMUC injection in chronic PIs in March 2017. Materials and Methods. This is a single-center, retrospective review of patients with nonhealing PIs treated with AMUC particulate between March 2017 and November 2018. Incidence of wound healing (zero wound volume with complete reepithelialization) was measured at 12, 24, 36, and 52 weeks. Results. Review included 26 PIs (21 patients); of which, 85% were stage 4 PIs, per the NPIAP staging system. After AMUC injection, 14 PIs (54%) achieved complete wound closure at a median of 12.4 weeks (range, 5-52 weeks). Complete wound closure was observed in 7 patients (27%) at 12 weeks, 10 patients (38%) at 24 weeks, 13 patients (50%) at 36 weeks, and 14 patients (54%) at 52 weeks. One patient with vascular issues required amputation; however, no treatment-related adverse events or complications were observed. Conclusions. These preliminary results suggest that injection of AMUC particulate may be a safe and promising treatment in promoting wound closure of difficult-to-treat PIs.
C1 [Mancino, Anne T.; Acott, Alison; Brinegar, Kathryn P.] Cent Arkansas Vet Healthcare Syst, Surg Serv, Little Rock, AR 72205 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Mancino, AT (通讯作者)，Cent Arkansas Vet Healthcare Syst, 4300 West 7th St, Little Rock, AR 72205 USA.
EM Anne.mancino@va.gov
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NR 46
TC 4
Z9 4
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2022
VL 34
IS 9
BP E85
EP E90
DI 10.25270/wnds/21041
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA D0QP4
UT WOS:000965861900004
PM 36252270
DA 2026-07-24
ER

PT J
AU Cheng, S
   Poh, BRM
   Tay, VWY
   Lee, PP
   Mathur, S
AF Cheng, Stephanie
   Poh, Benjamin Rui-Min
   Tay, Vivyan Wei Yen
   Lee, Piea Peng
   Mathur, Sachin
TI The interplay between diabetes Mellitus and soft tissue infections in
   general surgical patients
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Abscess; Acute care surgery; Diabetes; Infection; Soft tissue infections
ID GLYCEMIC CONTROL; STAY
AB BackgroundDiabetes mellitus (DM) is a worldwide pandemic affecting 500 million people. It is known to be associated with increased susceptibility to soft tissue infections (STI). Despite being a major public health burden, the literature relating the effects of DM and the presentation, severity and healing of STIs in general surgical patients remain limited.MethodWe conducted a retrospective review of all patients admitted with STI in a tertiary teaching hospital over a 12-month period. Patient demographics and surgical outcomes were collected and analysed.ResultsDuring the study period, 1059 patients were admitted for STIs (88% required surgery). DM was an independent risk factor for LOS. Diabetic patients presented with higher body-mass index (28 vs. 26), larger abscess size (24 vs. 14 cm2) and had a longer length of stay (4.4 days vs. 2.9 days). They also underwent a higher proportion of wide debridement and application of negative pressure wound therapy (42% vs. 35%). More diabetic patients underwent subsequent re-operation within the same sitting (8 vs. 4). Diabetic patients were two times more likely to present with carbuncles (p = 0.02).ConclusionThe incidence of STIs among DM patients represent a significant disease burden, surgeons should consider intensive patient counselling and partnering with primary care providers in order to help reduce the incidence of future STI admissions based upon lifestyle modification and glucose control.
C1 [Cheng, Stephanie; Poh, Benjamin Rui-Min; Tay, Vivyan Wei Yen; Mathur, Sachin] Singapore Gen Hosp, Dept Gen Surg, Singapore, Singapore.
   [Lee, Piea Peng] Natl Canc Ctr, Div Surg Oncol, Singapore, Singapore.
C3 Singapore General Hospital; National Cancer Centre Singapore (NCCS)
RP Mathur, S (通讯作者)，Singapore Gen Hosp, Dept Gen Surg, Singapore, Singapore.
EM sachinmathur60@gmail.com
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NR 22
TC 6
Z9 6
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 8
PY 2024
VL 24
IS 1
AR 106
DI 10.1186/s12902-024-01636-y
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XZ5B6
UT WOS:001265503600003
PM 38978006
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Vaddavalli, V
   Girdhani, B
   Savlania, A
   Behera, A
   Rastogi, A
   Kaman, L
   Abuji, K
AF Vaddavalli, Vv
   Girdhani, B.
   Savlania, A.
   Behera, A.
   Rastogi, A.
   Kaman, L.
   Abuji, K.
TI Effectiveness of incisional negative pressurewound therapy after major
   lower extremityamputation: a randomised controlled trial
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Amputation; Surgical site infection; PAD; iNPWT; Stump dehiscence; RCT
ID SURGICAL SITE INFECTION; WOUND THERAPY; COMPLICATIONS
AB Introduction The aim was to study the effect of incisional negative pressure wound therapy (iNPWT) in wound healing compared with standard sterilegauze dressings after major lower extremity amputation in patients with peripheral arterial disease (PAD). Methods This prospective, randomised controlled trial included 50 patients undergoing major lower extremity amputations for PAD. Patients wererandomised into iNPWT and standard dressing groups. The patency of blood vessels at the level of the stump was ensured with or withoutrevascularisation. The primary outcome was wound-related complications such as surgical site infection (SSI), wound dehiscence, seroma/haematoma formation or the need for revision amputation. The secondary outcome was the time taken for the eligibility of prosthesis placement. Results It was found that only 12% of the patients in the iNPWT group had SSI compared with 36% in the standard dressing group (p=0.047). Rates ofwound dehiscence, seroma/haematoma formation and revision amputation were decreased in the iNPWT group but this was not statistically significant(p> 0.05). There was a significant reduction in the time taken for eligibility of prosthesis placement in the iNPWT group (5.12 +/- 1.53 vs 6.8 +/- 1.95 weeks,p=0.002). Conclusions iNPWT is effective in reducing the incidence of SSI and the time taken for rehabilitation in patients undergoing major lower limb amputationdue to PAD
C1 [Vaddavalli, Vv; Girdhani, B.; Savlania, A.; Behera, A.; Rastogi, A.; Kaman, L.; Abuji, K.] Post Grad Inst Med Educ & Res, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Savlania, A (通讯作者)，Post Grad Inst Med Educ & Res, Chandigarh, India.
EM drajaysavlania@gmail.com
RI Rastogi, Ashu/AAW-1759-2020; kaman, lileswar/AAO-7634-2021
FU Department of General Surgery, Post Graduate Institute of Medical
   Education and Research, Chandigarh, India
FX We received a research grant from the Department of General Surgery,
   Post Graduate Institute of Medical Education and Research, Chandigarh,
   India.
CR Advanced Amputee Solutions, Amputee Statistics
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NR 28
TC 4
Z9 4
U1 0
U2 1
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD MAY
PY 2024
VL 106
IS 5
DI 10.1308/rcsann.2023.0011
PG 84
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TC0W2
UT WOS:001238951600006
PM 37435705
OA Green Submitted
DA 2026-07-24
ER

PT J
AU van de Voort, JC
   Brekelmans, W
   Ritchie, ED
   Leijnen, M
AF van de Voort, Jan C.
   Brekelmans, Wouter
   Ritchie, Ewan D.
   Leijnen, Michiel
TI Preventing Surgical Site Infections in Geriatric Ankle Fracture Surgery
   with Closed-Incision Vacuum Therapy: A Pilot Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE ankle fracture; closed-incision vacuum therapy; geriatric;
   negative-pressure wound therapy; surgery; surgical site infection; wound
   infection
ID RISK-FACTORS; OPERATIVE TREATMENT; INTERNAL-FIXATION; COMPLICATIONS;
   IMPACT; DRESSINGS; RATES; LIFE; HIP
AB BackgroundAnkle fractures are among the most common fractures in older adult patients that need surgical treatment. The risk of surgical site infections (SSIs) after ankle fracture surgery ranges between 0.5% and 30%; SSI incidence is higher among older adults. Further, SSIs have significant consequences for subjective functional outcomes and create a need for prolonged intravenous antibiotic therapy and wound care. Accordingly, it is critical to determine risk factors for and establish optimal postoperative wound care to prevent SSIs.ObjectiveThe aim of the pilot study was to examine the feasibility of closed-incision vacuum therapy (CIVT) to reduce rates of SSI in older adults.MethodsThe authors performed a pilot study of a CIVT system in a population of 10 older adult patients after ankle fracture surgery.ResultsNine patients experienced uncomplicated wound healing of the lateral incision. One patient (10%) developed an SSI after premature removal of the vacuum system because of technical failure. Six weeks postoperation, overall satisfaction with the CIVT was high; none of the participants complained of incapacitating discomfort or disruptive limitations in postsurgical recovery.ConclusionsThe authors conclude that CIVT is a feasible, safe, and generally well-tolerated therapy to prevent SSIs in postoperative wound healing after open reduction and internal fixation in older adult patients after ankle fracture.
C1 [van de Voort, Jan C.] Alrijne Hosp, Leiderdorp, Netherlands.
   [Brekelmans, Wouter] Alrijne Wound Ctr, Leiderdorp, Netherlands.
RP van de Voort, JC (通讯作者)，Alrijne Hosp, Leiderdorp, Netherlands.
EM jcvandevoort@alrijne.nl; wbrekelmans@alrijne.nl; edritchie@alrijne.nl;
   mleijnen@alrijne.nl
CR Aigner R, 2017, FOOT ANKLE INT, V38, P41, DOI 10.1177/1071100716667315
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NR 34
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2024
VL 37
IS 4
BP 6
EP 6
DI 10.1097/ASW.0000000000000124
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA A1O2Z
UT WOS:001280290800012
PM 38506586
DA 2026-07-24
ER

PT J
AU De Matteis, A
   Sacco, M
   Napoletano, P
   Pizzoleo, S
   Palazzo, P
   Angrisano, A
   Pungente, S
   Lamacchia, D
   Erario, S
   Bellanova, G
AF De Matteis, Antonio
   Sacco, Michele
   Napoletano, Pasqua
   Pizzoleo, Stefano
   Palazzo, Paola
   Angrisano, Anna
   Pungente, Salvatore
   Lamacchia, Domenico
   Erario, Silvia
   Bellanova, Giovanni
TI From damage control surgery to complex abdominal wall reconstruction It
   is possible even in the elderly in a Spoke Center?
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Damage Control Surgery (DCS); Giant incisional Hernia; Abdominal Wall
   Repair
AB AIM: To describe our Spoke Center experience in Damage Control Surgery (DCS) in a non traumatic patient and the possibility of delayed abdominal wall reconstruction (AWR).Material of Study The case of a 73 years old Caucasian male treated with DCS for a septic shock due to a duodenal perforation and his clinical course till the abdominal wall reconstruction.RESULTS: We made DCS with abbreviated laparotomy, suture of the ulcer and duodenostomy with a foley placed in right hypochondrium. Patiens was discharged with a low-flow fistula and with TPN. After 18 months we made an open chole-cystectomy and a complete abdominal wall reconstruction with Fasciotens Hernia System (R) adding a biological mesh.DISCUSSION AND COMMENTS: Periodic training in emergency settings and in complex abdominal wall procedures is the right way to manage critic clinical case. Like Niebuhr's abbreviated laparotomy experience also in our case this proce-dure allows primary closure of complex hernias and is potentially less prone to complications than component separation methods. Unlike Fung's experience we didn' t use negative pressure wound therapy system (NPWT) equally achieving good results.CONCLUSIONS: Elective repair of abdominal wall disaster is possible even in elderly patients who have been treated by abbreviated laparotomy and DCS surgery. In order to obtain good results is fundamental to have a trained staff.
C1 [De Matteis, Antonio; Sacco, Michele; Napoletano, Pasqua; Pizzoleo, Stefano; Palazzo, Paola; Angrisano, Anna; Pungente, Salvatore; Lamacchia, Domenico; Erario, Silvia; Bellanova, Giovanni] UOC Chirurg Gen D Camberlingo Francavilla, Fontana, Italy.
RP De Matteis, A (通讯作者)，UOC Chirurg Gen D Camberlingo Francavilla, Fontana, Italy.
EM andematteis87@gmail.com
RI Lamacchia, Donatella/LFS-1913-2024
CR Eickhoff R, 2019, BMC SURG, V19, DOI 10.1186/s12893-019-0543-3
   Eucker D, 2022, SURG INNOV, V29, P169, DOI 10.1177/15533506211041477
   Fung S, 2022, LANGENBECK ARCH SURG, V11, P1, DOI [10.1007/s00423-021-02424, DOI 10.1007/S00423-021-02424]
   Hees A, 2020, CASE REP SURG, V2020, DOI 10.1155/2020/8254804
   Niebuhr H, 2022, CHIRURG, V93, P292, DOI 10.1007/s00104-021-01552-0
   Niebuhr H, 2021, FRONT SURG, V7, DOI 10.3389/fsurg.2020.616669
NR 6
TC 1
Z9 1
U1 0
U2 1
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD JAN-FEB
PY 2023
VL 94
IS 1
BP 95
EP 98
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA E9TY9
UT WOS:000978892100014
PM 36810304
DA 2026-07-24
ER

PT J
AU Smolle, MA
   Nischwitz, SP
   Hutan, M
   Trunk, P
   Lumenta, D
   Bernhardt, GA
AF Smolle, Maria A.
   Nischwitz, Sebastian P.
   Hutan, Martin
   Trunk, Primoz
   Lumenta, David
   Bernhardt, Gerwin A.
TI Closed-incision negative-pressure wound management in surgery-literature
   review and recommendations
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Review
DE Surgical site infection; Negative-pressure wound dressing; ciNPWT; Wound
   healing deficit; Postoperative wound complications
ID SURGICAL SITE INFECTION; RANDOMIZED CLINICAL-TRIAL; FLAP DONOR SITE;
   CARDIAC-SURGERY; REVISION HIP; THERAPY; PREVENTION; SYSTEM;
   COMPLICATIONS; METAANALYSIS
AB Background Wound healing deficits and subsequent surgical site infections are potential complications after surgical procedures, resulting in increased morbidity and treatment costs. Closed-incision negative-pressure wound therapy (ciNPWT) systems seem to reduce postoperative wound complications by sealing the wound and reducing tensile forces. Materials and methods We conducted a collaborative English literature review in the PubMed database including publications from 2009 to 2020 on ciNPWT use in five surgical subspecialities (orthopaedics and trauma, general surgery, plastic surgery, cardiac surgery and vascular surgery). With literature reviews, case reports and expert opinions excluded, the remaining 59 studies were critically summarized and evaluated with regard to their level of evidence. Results Of nine studies analysed in orthopaedics and trauma, positive results of ciNPWT were reported in 55.6%. In 11 of 13 (84.6%), 13 of 15 (86.7%) and 10 of 10 (100%) of studies analysed in plastic, vascular and general surgery, respectively, a positive effect of ciNPWT was observed. On the contrary, only 4 of 12 studies from cardiac surgery discovered positive effects of ciNPWT (33.3%). Conclusion ciNPWT is a promising treatment modality to improve postoperative wound healing, notably when facing increased tensile forces. To optimise ciNPWT benefits, indications for its use should be based on patient- and procedure-related risk factors.
C1 [Smolle, Maria A.; Bernhardt, Gerwin A.] Med Univ Graz, Dept Orthopaed & Trauma, Auenbruggerpl 5, A-8036 Graz, Austria.
   [Nischwitz, Sebastian P.; Lumenta, David] Med Univ Graz, Div Plast Aesthet & Reconstruct Surg, Graz, Austria.
   [Hutan, Martin] Landesklinikum Hainburg, Dept Surg, Hainburg Donau, Austria.
   [Trunk, Primoz] Univ Ljubljana, Dept Cardiovasc Surg, Med Ctr, Ljubljana, Slovenia.
   [Nischwitz, Sebastian P.] JOANNEUM RES Forsch Gesell mbH, COREMED Cooperat Ctr Regenerat Med, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; University of
   Ljubljana
RP Bernhardt, GA (通讯作者)，Med Univ Graz, Dept Orthopaed & Trauma, Auenbruggerpl 5, A-8036 Graz, Austria.
EM gerwin.bernhardt@medunigraz.at
RI Bernhardt, Gerwin/F-2196-2010; Lumenta, David/AAD-5935-2019
OI Nischwitz, Sebastian P/0000-0002-6621-4891; 
FU Medical University of Graz
FX Open access funding provided by Medical University of Graz.
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NR 84
TC 6
Z9 9
U1 0
U2 6
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2020
VL 52
IS 6
BP 249
EP 267
DI 10.1007/s10353-020-00657-w
EA AUG 2020
PG 19
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OV9WT
UT WOS:000562351800001
OA hybrid
DA 2026-07-24
ER

PT J
AU Kabra, R
   Poonia, N
   Subudhi, RN
   Singh, T
   Joshi, G
   Sharma, R
   Arora, V
AF Kabra, Ruchika
   Poonia, Neelam
   Subudhi, Rudra Narayan
   Singh, Tajinder
   Joshi, Gaurav
   Sharma, Rajiv
   Arora, Vimal
TI Innovative strategies for the management of diabetic wounds: A step
   toward faster recovery
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Diabetic wound healing; Wound care products; Angiogenesis; Tissue
   regeneration; Anti-oxidant; Ant inflammatory
ID ELECTRICAL-STIMULATION; FOOT ULCERS; HYDROGEL; NANOPARTICLES; THERAPY
AB Impaired wound healing is a serious healthcare complication in diabetic individuals, marked by prolonged healing durations and increased susceptibility to infections, impacting a substantial population. It mainly involves a multifaceted pathophysiology, including chronic hyperglycemia, neuropathy, reduced angiogenesis, and dysregulated inflammatory responses, which together result in delayed healing and lead to complications like chronic wounds and increased healthcare costs. As the incidence rate of diabetes becomes rising at higher proportion, understanding the mechanisms of diabetic wound healing and implementing effective treatment modalities is crucial for personalizing patient care and lifestyle. Latest advancements in diabetic wound healing strategies facilitate tissue regeneration through hydrogels for optimal moisture balance, biological dressings with antimicrobial properties, and stem cell therapies promoting cellular repair. In addition, innovative approaches such as 3D bioprinting enable the precise deposition of cells and bioactive molecules to accelerate wound healing. Moreover, the potential of innovative treatments, viz. electrical stimulation and vacuum assisted or negative pressure wound therapy (NPWT), to enhance healing outcomes has been employed. This review offers an in-depth look at current practices and emerging trends in diabetic wound management. By exploring recent findings, it delivers a comprehensive report on the revolutionary era of diabetic wound healing therapies. Integrating these innovative therapies with conventional wound care can overcome the limitations of traditional treatments, improve healing outcomes, and enhance the quality of life for diabetic individuals.
C1 [Kabra, Ruchika; Poonia, Neelam; Singh, Tajinder; Joshi, Gaurav; Sharma, Rajiv; Arora, Vimal] Chandigarh Univ, Univ Inst Pharm Sci, Mohali 140413, Punjab, India.
   [Subudhi, Rudra Narayan] JBIT Coll Pharm, 23 Milestone,NH-07,Chakrata Rd, Dehra Dun 248197, Uttarakhnd, India.
C3 Chandigarh University
RP Poonia, N (通讯作者)，Chandigarh Univ, Univ Inst Pharm Sci, Mohali 140413, Punjab, India.
EM neelampoonia123@gmail.com
RI Arora, Vimal/AAF-4297-2021; Joshi, Gaurav/AEE-2196-2022
OI Arora, Vimal/0000-0001-9520-138X; Poonia, Neelam/0000-0002-5884-9264;
   Joshi, Gaurav/0000-0002-1033-0199
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NR 106
TC 1
Z9 1
U1 4
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD JAN
PY 2026
VL 115
AR 107824
DI 10.1016/j.jddst.2025.107824
EA NOV 2025
PN 2
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M6342
UT WOS:001630767400004
DA 2026-07-24
ER

PT J
AU Ross, K
   Zinck, N
   Wilson, D
   Rasmussen, J
   Biddulph, M
   Williams, J
AF Ross, Katie
   Zinck, Nicholas
   Wilson, David
   Rasmussen, Jack
   Biddulph, Michael
   Williams, Jason
TI Integra Dermal Regeneration Template in Reconstruction of Primary
   Oncologic Defects in the Lower Extremities: A Case Series
SO PLASTIC SURGERY
LA English
DT Article
DE integra dermal regeneration template; integra; reconstruction; oncology;
   extremity; matrice de r & eacute;g & eacute;n & eacute;ration dermique
   Integra; oncologie; extr & eacute;mit & eacute;
ID MATRIX
AB This article presents a case series of 4 patients who underwent primary reconstruction of oncologic defects in the lower extremities using Integra Dermal Regeneration Template (IDRT). The patients had either primary or recurrent tumors, which resulted in exposure of deep underlying structures including tendon, nerve, muscle, and bone. IDRT was selected to manage these defects due to the uncertain malignant potential of tissue margins and its ability to facilitate later margin revision without sacrificing tissue. The use of IDRT allowed for the growth of a neodermis that supported subsequent split-thickness skin grafting in all cases. Additionally, for those with positive margins, surgical revision and skin graft application was able to be performed in a single procedure, maximizing operating room use and patient convenience. This case series highlights the potential of IDRT in managing complex oncologic defects in the lower extremities, expanding options for reconstructive surgeons. Key findings: (1) IDRT is a viable option for reconstruction in oncologic resections exposing deep structures. (2) In cases with unknown malignant potential of tissue margins, use of IDRT can allow for revision of positive margins without sacrificing graft or flap tissue. (3) Negative pressure wound therapy is an important adjunct in achieving a favorable neodermis for acceptance of a spilt thickness skin graft.
C1 [Ross, Katie; Rasmussen, Jack; Williams, Jason] Dalhousie Univ, Dept Surg, Div Plast Surg, 1796 Summer St, Room 4447, Halifax, NS B3H 3A7, Canada.
   [Zinck, Nicholas] Dalhousie Univ, Fac Med, Halifax, NS, Canada.
   [Wilson, David; Biddulph, Michael] Dalhousie Univ, Dept Surg, Div Orthoped Surg, Halifax, NS, Canada.
   [Rasmussen, Jack] Dalhousie Univ, Dept Crit Care Med, Halifax, NS, Canada.
C3 Dalhousie University; Dalhousie University; Dalhousie University;
   Dalhousie University
RP Ross, K (通讯作者)，Dalhousie Univ, Dept Surg, Div Plast Surg, 1796 Summer St, Room 4447, Halifax, NS B3H 3A7, Canada.
EM katie.ross@dal.ca
OI Wilson, David/0000-0001-8372-3041; Ross, Katie/0009-0000-4795-2410
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NR 16
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD MAY
PY 2026
VL 34
IS 2
BP 354
EP 360
DI 10.1177/22925503251336254
EA MAY 2026
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4FJ
UT WOS:001483484000001
PM 40352380
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Deng, XX
   Gould, M
   Ali, MA
AF Deng, Xiaoxuan
   Gould, Maree
   Ali, M. Azam
TI A review of current advancements for wound healing: Biomaterial
   applications and medical devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Review
DE biomaterial; biomedical device; chronic wound; wound healing
ID DRESSING IN-VITRO; SILK FIBROIN; ELECTROSPUN NANOFIBERS; SURGICAL
   SUTURES; GROWTH-FACTORS; STEM-CELLS; ANTIBACTERIAL ACTIVITY;
   EXTRACELLULAR-MATRIX; SUSTAINED-RELEASE; COATED SUTURES
AB Wound healing is a complex process that is critical in restoring the skin's barrier function. This process can be interrupted by numerous diseases resulting in chronic wounds that represent a major medical burden. Such wounds fail to follow the stages of healing and are often complicated by a pro-inflammatory milieu attributed to increased proteinases, hypoxia, and bacterial accumulation. The comprehensive treatment of chronic wounds is still regarded as a significant unmet medical need due to the complex symptoms caused by the metabolic disorder of the wound microenvironment. As a result, several advanced medical devices, such as wound dressings, wearable wound monitors, negative pressure wound therapy devices, and surgical sutures, have been developed to correct the chronic wound environment and achieve skin tissue regeneration. Most medical devices encompass a wide range of products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, and silk fibroin) and synthetic (e.g., polyvinyl alcohol, polyethylene glycol, poly[lactic-co-glycolic acid], polycaprolactone, polylactic acid) polymers, as well as bioactive molecules (e.g., chemical drugs, silver, growth factors, stem cells, and plant compounds). This review addresses these medical devices with a focus on biomaterials and applications, aiming to deliver a critical theoretical reference for further research on chronic wound healing.
C1 [Deng, Xiaoxuan; Gould, Maree; Ali, M. Azam] Univ Otago, Fac Dent, Ctr Bioengn & Nanomed Dunedin, Dept Oral Rehabil, Dunedin, New Zealand.
C3 University of Otago
RP Ali, MA (通讯作者)，Univ Otago, Polymer & Biomat Sci & Engn, Dunedin, New Zealand.
EM azam.ali@otago.ac.nz
RI Ali, Azam/PKR-6193-2026; Deng, Xiaoxuan/GQR-1757-2022
OI Deng, Xiaoxuan/0000-0002-8152-875X
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NR 287
TC 249
Z9 284
U1 14
U2 196
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD NOV
PY 2022
VL 110
IS 11
BP 2542
EP 2573
DI 10.1002/jbm.b.35086
EA MAY 2022
PG 32
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 4N7DJ
UT WOS:000796484200001
PM 35579269
OA Green Submitted, hybrid
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Song, HP
   Gong, YL
   Yan, XC
   Zhang, JP
AF Song, Huapei
   Gong, Yali
   Yan, Xiaochu
   Zhang, Jiaping
TI A Rare Case of Cutaneous Diffuse Large B-cell Lymphoma Presenting as a
   Chronic "Infectious" Skin Ulcer
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; wound; infection; cutaneous; lymphoma
AB Cutaneous diffuse large B-cell lymphoma (DLBCL) usually manifests as papules, nodules, or plaques. A rare case of a patient with a chronic skin ulcer and signs and symptoms of infection, including fever and large amounts of yellow wound exudate, is presented. Fifteen (15) months before diagnosis, a 43-year-old otherwise healthy man noted soreness without apparent cause in his upper chest and a palpable 2 cm x 2 cm focal lump. The patient developed frequent fevers, and the lump enlarged over time, producing purulent exudate. For 14 months, the patient was examined and treated at 5 hospitals, but biopsies, smears, cultures, and various types of nucleic acid testing were negative. Antibiotics to treat the suspected but nonclassified infection were ineffective. Ultimately, debridement and pathological examination of necrotic tissue from the deep sinus revealed DLBCL. The patient was provided chemotherapy, surgical debridement, and negative pressure wound therapy. Wounds started to reduce in size once chemotherapy was initiated. The wound was surgically closed with a split-skin graft, and the patient was discharged 93 days following admission to the authors' facility. This case illustrates the possibility of cutaneous DLBCL in patients with chronic skin ulcers and infectious manifestation that do not respond to antibiotic therapy. Prompt deep tissue debridement and pathological examination of deep tissue will help confirm the presence of cutaneous DLBCL and guide required chemotherapy.
C1 [Song, Huapei; Gong, Yali; Yan, Xiaochu; Zhang, Jiaping] Third Mil Med Univ, Southwest Hosp, State Key Lab Trauma Burns & Combined Injury, Inst Burn Res, Chongqing, Peoples R China.
C3 Army Medical University
RP Zhang, JP (通讯作者)，Third Mil Med Univ, Southwest Hosp, Inst Burn Res, Chongqing, Peoples R China.
EM 1980475546@qq.com
FU National Natural Science Foundation of China [81571900]
FX This project was supported by National Natural Science Foundation of
   China (81571900).
CR Adams HJA, 2016, CRIT REV ONCOL HEMAT, V106, P55, DOI 10.1016/j.critrevonc.2016.07.003
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NR 8
TC 1
Z9 2
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2018
VL 64
IS 4
BP 44
EP 47
DI 10.25270/owm.2018.4.4447
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GN8QE
UT WOS:000439432200009
PM 29718817
DA 2026-07-24
ER

PT J
AU Tiwari, N
   Ganguly, G
   Garg, A
AF Tiwari, Nikhil
   Ganguly, Gautam
   Garg, Anurag
TI Use of Improvised Vaccum Assisted Suction Drainage for Cases of Deep
   Sternal Wound Infection
SO HEART LUNG AND CIRCULATION
LA English
DT Editorial Material
DE Deep sternal wound infection; Negative pressure wound therapy;
   Improvised components
ID THERAPY
AB Aim: To devise a simple, cheap and effective improvised method of treating deep sternal wound infections (DSWI) by negative pressure obviating high cost of patented systems.
   Method: Records of ten post CABG patients operated via median sternotomy approach over a two and half year period and treated for DSWI were analysed. Sterile foam with drain was placed in the wound, which was covered with Ioban (Steridrape), the drain being connected to a suction unit maintaining 100 mm Hg pressure (<$12 cost).
   Results: Ten (10) patients of DSWI were managed with this therapy. Mean age was 60.4 years. Pseudomonas found in 1 (10%), Acinetobacter and Pseudomonas in 1 (10%) with Escherichia coli in 1 (10%). Five (50%) patients had diabetes mellitus. Mean hospitalisation period was 43 days. Seven (70%) patients underwent secondary suturing. Two (22%) patients had relapse, which was managed with dressings and secondary intention suturing. One patient who underwent a muscle flap cover had major recurrence with multiple sinuses. Excellent wound healing in 9 (90%) patients with no (0%) 90-day mortality Improvised components can be safely employed to provide effective negative pressure therapy for DSWI with excellent results. (Heart, Lung and Circulation 2013;22:542-544) (C) 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier Inc. All rights reserved.
C1 [Tiwari, Nikhil; Ganguly, Gautam; Garg, Anurag] Mil Hosp, Ctr Cardiothorac, Dept CTVS, Pune 411040, Maharashtra, India.
RP Tiwari, N (通讯作者)，Mil Hosp, Ctr Cardiothorac, Dept CTVS, Kondhwa Rd, Pune 411040, Maharashtra, India.
EM nikhil1972@rediffmail.com
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NR 8
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1443-9506
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD JUL
PY 2013
VL 22
IS 7
BP 542
EP 544
DI 10.1016/j.hlc.2012.11.013
PG 3
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 182DQ
UT WOS:000321722300007
PM 23474281
DA 2026-07-24
ER

PT J
AU Struebing, F
   Xiong, LY
   Bigdeli, AK
   Diehm, Y
   Kneser, U
   Hirche, C
   Gazyakan, E
AF Struebing, Felix
   Xiong, Lingyun
   Bigdeli, Amir K.
   Diehm, Yannick
   Kneser, Ulrich
   Hirche, Christoph
   Gazyakan, Emre
TI Microsurgical Strategies after Free Flap Failure in Soft Tissue
   Reconstruction of the Lower Extremity: A 17-Year Single-Center
   Experience
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE lower extremity; free flap; flap failure; secondary free flap; tertiary
   free flap; orthoplastic; limb salvage
ID FAILED FREE FLAPS; LIMB INJURIES; OUTCOMES; SALVAGE; DEFECTS;
   METAANALYSIS; AMPUTATION; CONSENSUS; TRAUMA; MULTICENTER
AB Background: There is no clear consensus on the optimal surgical strategy for providing safe coverage in salvage free flap surgery after total free flap failure. Methods: A retrospective study was conducted to evaluate patients with total failure of the primary free flap in lower extremity reconstruction between 2000 and 2017. Results: In a cohort of 1.016 patients, we identified 43 cases of total flap failure (4.2%). A total of 30 patients received a salvage free flap with a success rate of 83.3% (25/30). One patient received a secondary salvage free flap. Overall limb salvage after primary free flap loss was 83.7% (36/43). Conclusions: Microsurgical management of free flap loss in the lower extremity is challenging and requires a decisive re-evaluation of risk factors and alternative strategies. This should include reconsidering the flap choice with a tendency towards traditional and safe workhorse flaps, a low-threshold switch to different recipient vessels, including arteriovenous (AV) loops, bypasses (especially in case of venous insufficiency) and back-up procedures, such as negative pressure wound therapy or dermal regeneration templates with skin grafting in cases of lower demand and critically ill patients. We derived one suggestion from our previous practice: replacing perforator flaps with axial pattern flaps ("safe workhorses").
C1 [Struebing, Felix; Xiong, Lingyun; Bigdeli, Amir K.; Diehm, Yannick; Kneser, Ulrich; Hirche, Christoph; Gazyakan, Emre] Heidelberg Univ, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg, D-67071 Ludwigshafen, Germany.
   [Xiong, Lingyun] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Plast Surg, Wuhan 430022, Peoples R China.
   [Hirche, Christoph] Goethe Univ Frankfurt, Hand Trauma & Replantat Ctr, BG Trauma Ctr Frankfurt Main, Dept Plast Hand & Reconstruct Microsurg,Affiliate, D-60389 Frankfurt, Germany.
C3 Ruprecht Karls University Heidelberg; Huazhong University of Science &
   Technology; Goethe University Frankfurt
RP Gazyakan, E (通讯作者)，Heidelberg Univ, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg, D-67071 Ludwigshafen, Germany.
EM emre.gazyakan@bgu-ludwigshafen.de
RI ; Gazyakan, Emre/HLW-5585-2023
OI Hirche, Christoph/0000-0001-6112-8671; Kneser,
   Ulrich/0000-0002-3402-2860; Gazyakan, Emre/0000-0003-2826-2793; Bigdeli,
   Amir Khosrow/0000-0001-8852-5132
CR Akula M, 2011, INJURY, V42, P1194, DOI 10.1016/j.injury.2010.05.003
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NR 46
TC 10
Z9 12
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD OCT
PY 2022
VL 12
IS 10
AR 1563
DI 10.3390/jpm12101563
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 5P0NC
UT WOS:000872857500001
PM 36294702
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hsiao, HY
   Hsieh, WC
   Chang, FCS
   Liu, JW
   Kuo, WL
   Cheong, DCF
   Huang, JJ
AF Hsiao, Hui-Yi
   Hsieh, Wei-Chuan
   Chang, Frank Chun-Shin
   Liu, Jia-Wei
   Kuo, Wen-Ling
   Cheong, David Chon-Fok
   Huang, Jung-Ju
TI The Effect of Negative Pressure on Wound Healing and Regeneration in
   Closed Incisions under High Tension: Evidence from Animal Studies and
   Clinical Experience
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure; tensioned wound healing; profunda artery perforator
   flap; breast reconstruction
ID BREAST RECONSTRUCTION; THERAPY; INFLAMMATION; MANAGEMENT; INFECTION;
   SUTURE; FORCES
AB Closed-incision negative-pressure wound therapy (iNPWT) is known to enhance wound healing and tissue regeneration. The main aim of the present study is to investigate its effectiveness on enhancing wound healing under tension. An animal study was designed using a swine model by removing a skin flap to create a wound that could be closed primarily under tension, and iNPWT was applied. The enhancement of angiogenesis, lymphangiogenesis, collagen deposition, and tissue proliferation with reduced inflammation by iNPWT was confirmed by histology. The effect of iNPWT was further verified in patients receiving a profunda artery perforator (PAP) free flap for breast reconstruction. iNPWT was applied on the transversely designed donor site in continuous mode for 7 days, in which the wound was always closed under tension. A significant improvement in off-bed time was noted with the application of iNPWT (4.6 +/- 1.1st and 5.5 +/- 0.8th postoperative days in the iNPWT and control groups, respectively, p = 0.028). The control group (without iNPWT treatment) presented more cases of poor wound healing in the acute (23.1% vs. 0%) and wound breakdown in the late (23.1% vs. 8.3%) stages. The treatment of closed incisions under tension with iNPWT clinically enhances wound healing and tissue regeneration and with histological evidence.
C1 [Hsiao, Hui-Yi; Liu, Jia-Wei; Huang, Jung-Ju] Chang Gung Mem Hosp, Linkou Med Ctr, Ctr Tissue Engn, Taoyuan 333, Taiwan.
   [Hsieh, Wei-Chuan; Cheong, David Chon-Fok; Huang, Jung-Ju] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Reconstruct Microsurg,Dept Plas, Taoyuan 333, Taiwan.
   [Chang, Frank Chun-Shin] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Plast & Reconstruct Surg,Div Craniofacial Sur, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Breast Surg,Dept Surg, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling; Cheong, David Chon-Fok; Huang, Jung-Ju] Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan 333, Taiwan.
   [Kuo, Wen-Ling] Natl Tsing Hua Univ, Sch Med, Hsinchu 300, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; National Tsing Hua University
RP Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Linkou Med Ctr, Ctr Tissue Engn, Taoyuan 333, Taiwan.; Huang, JJ (通讯作者)，Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Linkou Med Ctr,Div Reconstruct Microsurg,Dept Plas, Taoyuan 333, Taiwan.; Huang, JJ (通讯作者)，Chang Gung Mem Hosp, Breast Canc Ctr, Linkou Med Ctr, Taoyuan 333, Taiwan.
EM jungjuhuang@gmail.com
RI ; HSIAO, HUI-YI/K-5428-2017; Cheong, David/LQK-7335-2024
OI Hsieh, Wei-Chuan/0000-0001-8978-7601; HSIAO, HUI-YI/0000-0003-3170-2112;
   Kuo, Wen-Ling/0000-0002-1145-8514
FU Chang Gung Memorial Hospital;  [CMRPG3I0131-2]
FX This work was supported and funded by Chang Gung Memorial Hospital,
   grant numbers CMRPG3I0131-2.
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   Zwanenburg PR, 2018, SURG INFECT, V19, P821, DOI 10.1089/sur.2018.212
NR 36
TC 8
Z9 9
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2023
VL 12
IS 1
AR 106
DI 10.3390/jcm12010106
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7R0UN
UT WOS:000909795100001
PM 36614907
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Silverman, RP
   Apostolides, J
   Chatterjee, A
   Dardano, AN
   Fearmonti, RM
   Gabriel, A
   Grant, RT
   Johnson, ON
   Koneru, S
   Kuang, AA
   Moreira, AA
   Sigalove, SR
AF Silverman, Ronald P.
   Apostolides, John
   Chatterjee, Abhishek
   Dardano, Anthony N.
   Fearmonti, Regina M.
   Gabriel, Allen
   Grant, Robert T.
   Johnson, Owen N.
   Koneru, Suresh
   Kuang, Anna A.
   Moreira, Andrea A.
   Sigalove, Steven R.
TI The use of closed incision negative pressure therapy for incision and
   surrounding soft tissue management: Expert panel consensus
   recommendations
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Delphi technique; negative pressure wound therapy; plastic surgery;
   surgical wound; wound healing
ID SURGICAL SITE INFECTION; NIPPLE-SPARING MASTECTOMY; WOUND THERAPY;
   POSTOPERATIVE COMPLICATIONS; METAANALYSIS; SURGERY; PREVENTION; RISK;
   RECONSTRUCTION; REDUCTION
AB As the use of closed incision negative pressure therapy (ciNPT) becomes more widespread, dressing designs have evolved to address implementation challenges and meet surgeon demand. While traditional application of ciNPT was limited to the immediate suture line, a novel dressing that covers the incision and additional surrounding tissues has become available. To expand upon previous ciNPT recommendations and provide guidance on this new dressing, an expert panel of plastic surgeons convened to review the current literature, identify challenges to the implementation and sustainability of ciNPT, and use a modified Delphi technique to form a consensus on the appropriate use of ciNPT with full-coverage dressings. After three rounds of collecting expert opinion via the Delphi method, consensus was reached if 80% of the panel agreed upon a statement. This manuscript establishes 10 consensus statements regarding when ciNPT with full-coverage foam dressings should be considered or recommended in the presence of patient or incision risk factors, effective therapeutic settings and duration, precautions for use, and tools and techniques to support application. The panel also discussed areas of interest for future study of ciNPT with full-coverage dressings. High-quality, controlled studies are needed to expand the understanding of the benefits of ciNPT over the incision and surrounding tissues.
C1 [Silverman, Ronald P.] Univ Maryland, Med Ctr, Dept Surg, Baltimore, MD 21201 USA.
   [Silverman, Ronald P.; Kuang, Anna A.] 3M Co, St Paul, MN 55144 USA.
   [Apostolides, John] Defy Plast & Reconstruct Surg, San Diego, CA USA.
   [Chatterjee, Abhishek] Tufts Med Ctr, Dept Surg, Boston, MA 02111 USA.
   [Dardano, Anthony N.] Florida Atlantic Univ, Dept Surg, Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA.
   [Fearmonti, Regina M.] Alon Aesthet Plast Surg, San Antonio, TX USA.
   [Grant, Robert T.] New York Presbyterian Hosp Columbia & Weill Corne, Div Plast & Reconstruct Surg, New York, NY USA.
   [Koneru, Suresh] Adv Concepts Plast Surg, San Antonio, TX USA.
   [Moreira, Andrea A.] Cleveland Clin, Lerner Coll Med, Dept Surg, Cleveland, OH 44106 USA.
   [Sigalove, Steven R.] Scottsdale Ctr Plast Surg, Paradise Valley, AZ USA.
C3 University System of Maryland; University of Maryland Baltimore; 3M;
   Tufts Medical Center; State University System of Florida; Florida
   Atlantic University; Cornell University; Weill Cornell Medicine;
   NewYork-Presbyterian Hospital; University System of Ohio; Case Western
   Reserve University; Cleveland Clinic Foundation
RP Silverman, RP (通讯作者)，Univ MD Surg Associates, 12203 Tullamore Rd,Roundwood Profess Bldg, Lutherville Timonium, MD 21093 USA.
EM rsilverman@mmm.com
RI Gabriel, Allen/AFK-3548-2022; Silverman, Ronald/A-5155-2018
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NR 72
TC 21
Z9 22
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2022
VL 19
IS 3
BP 643
EP 655
DI 10.1111/iwj.13662
EA AUG 2021
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ZH2HY
UT WOS:000684160700001
PM 34382335
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Reiter, G
   Thomas, B
   Kühner, C
   Hundeshagen, G
   Weil, F
   Wittenberg, G
   Kloos, S
   Grützner, PA
   Kneser, U
AF Reiter, G.
   Thomas, B.
   Kuehner, C.
   Hundeshagen, G.
   Weil, F.
   Wittenberg, G.
   Kloos, S.
   Gruetzner, P. A.
   Kneser, U.
TI Reconstruction of lower limbs in old age-an interdisciplinary approach
   Strategies for trauma surgery, vascular surgery and plastic surgery
SO CHIRURG
LA German
DT Article
DE Geriatric trauma; Vascular surgical reconstruction; Osteosynthesis;
   Plastic surgery; Interdisciplinary trauma treatment
ID FREE-FLAP RECONSTRUCTION; SOFT-TISSUE COVERAGE; DISTAL LOWER LEG;
   LOWER-EXTREMITY; BALLOON ANGIOPLASTY; PERONEUS BREVIS; RISK-FACTORS;
   FRACTURES; DEFECTS; MUSCLE
AB The treatment of complex injuries of the lower extremities in geriatric and/or multimorbid patients requires optimized preoperative and perioperative management as well as differentiated and interdisciplinary surgical approaches. Timely and definitive treatment should be strived for to avoid longer periods of immobilization. Temporary external stabilization of complex fractures, when necessary, should be followed by permanent loading stable internal osteosynthesis as soon as possible. Accompanying soft tissue defects are reconstructed after wound debridement using the full armamentarium of plastic and reconstructive surgical procedures, including microvascular free flap. In the context of perfusion compromised soft tissue situations, negative pressure wound therapy can provide sterile temporary defect coverage and aid in preconditioning poorly vascularized tissue before definitive reconstruction. A clarification of the vascular status in geriatric patients is paramount and relevant perfusion disorders should be treated either by intervention or open surgery before complex reconstructive interventions. Close interdisciplinary coordination of the various surgical procedures is imperative in order to guarantee an optimized stable reconstructive outcome with acceptable patient risk. Taking these principles into account, the reconstruction of complex trauma to the extremities can be carried out even in geriatric or multimorbid patients in specialized interdisciplinary surgical centers with excellent functional results.
C1 [Reiter, G.; Weil, F.; Gruetzner, P. A.] BG Unfallklin Ludwigshafen, Sekt Sept Chirurg, Klin Unfallchirurg & Orthopad, Ludwig Guttmann Str 13, Ludwigshafen, Germany.
   [Thomas, B.; Hundeshagen, G.; Kneser, U.] BG Unfallklin Ludwigshafen, Schwerbrandverletztenzentrum, Klin Hand Plast & Rekonstrukt Chirurg, Ludwigshafen, Germany.
   [Thomas, B.; Hundeshagen, G.; Kneser, U.] Heidelberg Univ, Klin Plast & Handchirurg, Heidelberg, Germany.
   [Kuehner, C.; Kloos, S.] Klinikum Stadt Ludwigshafen, Klin Gefasschirurg, Ludwigshafen, Germany.
   [Wittenberg, G.] BG Unfallklin Ludwigshafen, Klin Anasthesie Intens Med & Schmerztherapie, Ludwigshafen, Germany.
C3 Ruprecht Karls University Heidelberg; Ludwigshafen Hospital
RP Reiter, G (通讯作者)，BG Unfallklin Ludwigshafen, Sekt Sept Chirurg, Klin Unfallchirurg & Orthopad, Ludwig Guttmann Str 13, Ludwigshafen, Germany.
EM gregor.reiter@bgu-ludwigshafen.de
RI Thomas, Benjamin/HPI-2516-2023
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NR 51
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD OCT
PY 2019
VL 90
IS 10
SI SI
BP 806
EP 815
DI 10.1007/s00104-019-01023-7
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JA2KN
UT WOS:000487645700005
PM 31501936
DA 2026-07-24
ER

PT J
AU Inhoff, O
   Faulhaber, J
   Rothhaar, B
   Goerdt, S
   Koenen, W
AF Inhoff, Oliver
   Faulhaber, Joerg
   Rothhaar, Baerbel
   Goerdt, Sergij
   Koenen, Wolfgang
TI Analysis of treatment costs for complex scalp wounds
SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
LA English
DT Article
DE costs analysis; soft tissue reconstruction; dermal regeneration
   template; fascia lata; negative pressure therapy; collagen sheet
ID DERMAL REGENERATION TEMPLATE; RANDOMIZED CONTROLLED-TRIAL; MOHS
   MICROGRAPHIC SURGERY; BASAL-CELL CARCINOMA; FASCIA LATA; RECONSTRUCTIVE
   SURGERY; SURGICAL EXCISION; ARTIFICIAL SKIN; MANAGEMENT; DEFECTS
AB P>Background: Two stage reconstructions of deep scalp wounds with exposed calvarial bone require a vital granulation tissue. By evaluating different surgical approaches functional and cosmetic results as well as economic aspects have to be taken into account.
   Patients and Methods: 52 patients undergoing three different surgical procedures for soft tissue reconstruction of complex scalp wounds with exposed bone were included into a retrospective study. All patients underwent a two stage procedure with 3D histologic control, soft tissue reconstruction and final split thickness skin grafting. Soft tissue reconstruction was carried out using allogenic fascia lata, an artificial skin substitute or a negative pressure wound therapy (NPWT). The costs for all used materials as well as personnel and infrastructure were calculated.
   Results: Comparing the costs for the different treatments, the fascia lata group was least costly (4,475 euro) followed by the artificial skin substitute group (4,557 euro). The highest expenses occurred in the NPWT group (7,.521 euro). The artificial skin substitute group had the fewest dressing changes and the shortest treatment time.
   Conclusions: Although dermal regeneration templates are expensive, their use may be economic. NPWT causes high treatment costs due to high daily rental rates and frequent and time-consuming dressing changes.
C1 [Inhoff, Oliver; Faulhaber, Joerg; Goerdt, Sergij; Koenen, Wolfgang] Univ Heidelberg, Mannheim Med Sch, Univ Hosp Mannheim, Dept Dermatol Venerol & Allergol, D-6900 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg
RP Koenen, W (通讯作者)，UMM, Univ Heidelberg, Fac Mannheim, Klin Dermatol Venerol & Allergol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM wolfgang.koenen@umm.de
RI Koenen, Wolfgang/NUP-5484-2025
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NR 30
TC 15
Z9 16
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1610-0379
J9 J DTSCH DERMATOL GES
JI J. Dtsch. Dermatol. Ges.
PD NOV
PY 2010
VL 8
IS 11
BP 890
EP 896
DI 10.1111/j.1610-0387.2010.07474.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 669UP
UT WOS:000283376000005
PM 20629843
DA 2026-07-24
ER

PT J
AU Jo, C
   Choi, YJ
   Lee, TJ
AF Jo, Chanbee
   Choi, Yun Ji
   Lee, Tae-Jin
TI Therapeutic Potential of Stem Cell-Derived Exosomes in Skin Wound
   Healing
SO BIOMIMETICS
LA English
DT Review
DE adipose-derived stem cells; chronic wounds; exosomes; induced
   pluripotent stem cells; mesenchymal stem cells; skin wound regeneration
ID UMBILICAL-CORD; DENATURED DERMIS; GROWTH-FACTOR; ULCERS; ANGIOGENESIS;
   REGENERATION; FIBROBLASTS; EXPRESSION; FLUIDS; COST
AB Chronic skin wounds are difficult to heal or nonhealing. These wounds may become infected and progress to tissue necrosis, potentially leading to limb amputation, sepsis, reduced quality of life, depression, economic burden on the healthcare system, and social isolation. Several clinical strategies, including negative pressure wound therapy, antibiotic-based infection control, and wound debridement, have been developed to treat skin wounds. However, these approaches primarily target local wound conditions and offer only short-term relief, not achieving sustained functional regeneration. Stem cell-based therapy has emerged as an alternative therapeutic method for skin wound treatment owing to its ability to suppress inflammation, stimulate angiogenesis, and promote cellular proliferation. However, the low post-transplantation survival rate of stem cells remains a major limitation. Exosomes, nanosized extracellular vesicles, transport proteins, lipids, mRNAs, and miRNAs and mediate regenerative functions, including anti-inflammatory effects, angiogenesis promotion, and extracellular matrix remodeling. Stem cell-derived exosomes (SC-Exos) offer several advantages over their parent cells, including greater stability, lower immunogenicity, absence of tumorigenic risks, and ease of storage and distribution. These attributes render SC-Exos particularly attractive for cell-free regenerative therapies. In this review, we introduce exosomes derived from various types of stem cells and explore their therapeutic applications in skin wound regeneration.
C1 [Jo, Chanbee; Choi, Yun Ji; Lee, Tae-Jin] Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biotechnol, Div Biomed Convergence, Chuncheon Si 24341, South Korea.
C3 Kangwon National University
RP Lee, TJ (通讯作者)，Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biotechnol, Div Biomed Convergence, Chuncheon Si 24341, South Korea.
EM chanbi723@kangwon.ac.kr; cyj0887@naver.com; leetj@kangwon.ac.kr
OI Lee, Tae-Jin/0000-0001-6091-542X
FU the Korean government (MSIT) [RS-2023-00240571]; National Research
   Foundation of Korea (NRF) - Korean government (MSIT)
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No.
   RS-2023-00240571).
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NR 135
TC 8
Z9 9
U1 3
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2313-7673
J9 BIOMIMETICS-BASEL
JI Biomimetics
PD AUG 20
PY 2025
VL 10
IS 8
AR 546
DI 10.3390/biomimetics10080546
PG 23
WC Engineering, Multidisciplinary; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 6NY4R
UT WOS:001557872200001
PM 40862918
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nattrodt, JJM
   Bezerra-de-Freitas, VA
   Merval, APSS
   Filardi, ET
   Cerni, FA
   Dantas, DSM
   Lins, ABM
   Galan, LEB
   Carbonell, RC
   Pucca, MB
AF Nattrodt, Janio J. M.
   Bezerra-de-Freitas, Victoria A.
   Merval, Ana Paula S. S.
   Filardi, Eloise T.
   Cerni, Felipe A.
   Dantas, Domingos S. M.
   Lins, Alysson B. M.
   Galan, Luis E. B.
   Carbonell, Roberto C.
   Pucca, Manuela B.
TI Case report: Clinical management of freshwater stingray wounds using
   negative pressure therapy
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE ichthyism; stingray accident; stingray management; epidemiology; Amazon
ID SECONDARY INTENTION
AB Stingray injuries represent a significant occupational hazard, particularly for fishermen, and are commonly caused by freshwater stingrays of the Potamotrygonidae family. These stingrays are equipped with a sharp, bilaterally serrated spine that delivers venom, inducing vasoconstriction, severe pain, and ischemia. Such injuries are not only intensely painful but also debilitating, often rendering victims unable to work for weeks or even months. Traditional self-treatment practices, including the application of urine and herbal remedies, are widely relied upon in affected communities but are scientifically unproven and frequently lead to delayed or suboptimal care. This study presents two clinical cases of freshwater stingray envenomation from Roraima, the northernmost state of Brazil located within the Amazon Rainforest. Both cases were managed at the infectious disease unit of the General Hospital in Boa Vista, the state capital. Patients received evidence-based medical care, including intravenous antibiotic therapy and surgical debridement to remove necrotic and devitalized tissue. In one case, advanced negative pressure wound therapy (NPWT) was utilized during dressing changes, resulting in a clean wound devoid of edema and necrotic tissue, demonstrating the technique's effectiveness in promoting wound healing. By accelerating wound healing and mitigating complications such as infections and chronic wounds, NPWT significantly enhance patient outcomes. Furthermore, this study underscores the limitations of traditional remedies and advocates for the adoption of evidence-based interventions, particularly in regions like the Brazilian Amazon, where access to healthcare can be challenging.
C1 [Nattrodt, Janio J. M.; Lins, Alysson B. M.; Galan, Luis E. B.; Carbonell, Roberto C.] Gen Hosp Roraima, Boa Vista, Brazil.
   [Bezerra-de-Freitas, Victoria A.; Cerni, Felipe A.; Lins, Alysson B. M.; Galan, Luis E. B.; Carbonell, Roberto C.] Fed Univ Roraima UFRR, Med Sch, Boa Vista, Brazil.
   [Merval, Ana Paula S. S.] Fed Univ Roraima UFRR, Grad Program Hlth & Sci PROCISA, Boa Vista, Brazil.
   [Filardi, Eloise T.; Pucca, Manuela B.] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Grad Program Biosci & Biotechnol Appl Pharm, Araraquara, Brazil.
   [Dantas, Domingos S. M.] Fac Med Porto, Programa Doutoral Bioet, Porto, Portugal.
   [Pucca, Manuela B.] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil.
C3 Universidade Federal de Roraima; Universidade Federal de Roraima;
   Universidade Estadual Paulista; Universidade do Porto; Universidade
   Estadual Paulista
RP Carbonell, RC (通讯作者)，Gen Hosp Roraima, Boa Vista, Brazil.; Carbonell, RC (通讯作者)，Fed Univ Roraima UFRR, Med Sch, Boa Vista, Brazil.; Pucca, MB (通讯作者)，Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Grad Program Biosci & Biotechnol Appl Pharm, Araraquara, Brazil.; Pucca, MB (通讯作者)，Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil.
EM rcccarbonell@yahoo.es; manuela.pucca@unesp.br
RI Pucca, Manuela/IUQ-1517-2023
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2024/13258-0, 2024/01801-1]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [305778/2023-4]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. We thank
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP;
   scholarship to E.T.F. No. 2024/13258-0 and M.R. No. 2024/01801-1),
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   scholarship to M.P. No. 305778/2023-4).
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   Terapia de Feridas com Pressao Negativa, Uma Revisao de Seu Uso em Trauma Ortopedico
   Zaver V., 2025, Negative pressure wound therapy
NR 27
TC 1
Z9 2
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 10
PY 2025
VL 12
AR 1536540
DI 10.3389/fmed.2025.1536540
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0LX9A
UT WOS:001450505600001
PM 40130256
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Simon, S
   Frank, BJH
   Gardete, S
   Aichmair, A
   Mitterer, JA
   Dominkus, M
   Hofstaetter, JG
AF Simon, Sebastian
   Frank, Bernhard J. H.
   Gardete, Susana
   Aichmair, Alexander
   Mitterer, Jennyfer Angel
   Dominkus, Martin
   Hofstaetter, Jochen G.
TI Analysis of Failed Two-Stage Procedures with Resection Arthroplasty as
   the First Stage in Periprosthetic Hip Joint Infections
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE resection arthroplasty; two-stage procedure; risk-factors; PJI
ID PRESSURE WOUND THERAPY; KNEE ARTHROPLASTY; RISK; BIOMARKERS; REVISION;
   REIMPLANTATION; INCREASES; DIAGNOSIS; FAILURE; CULTURE
AB Resection arthroplasty can be performed as the first stage of a two-stage procedure in some patients with severe periprosthetic hip joint infections with poor bone stock. This retrospective study aimed to evaluate factors associated with the subsequent failure or success of these patients. Between 2011 and 2020; in 61 (26.4%) of 231 patients who underwent a two-stage protocol of periprosthetic hip joint infections; no spacer was used in the first stage. The minimum follow-up period was 12 months. Patient's demographics and various infection risk factors were analyzed. In total, 37/61 (60.7%) patients underwent a successful reimplantation, and four patients died within the follow-up period. Patients within the failure group had a significantly higher Charlson comorbidity index (p = 0.002); number of operations prior to resection arthroplasty (p = 0.022) and were older (p = 0.018). Failure was also associated with the presence of a positive culture in the first- and second-stage procedures (p = 0.012). Additional risk factors were persistent high postoperative CRP values and the requirement of a negative-pressure wound therapy (p & LE; 0.05). In conclusion, multiple factors need to be evaluated when trying to predict the outcome of patients undergoing resection arthroplasty as the first stage of a two-stage procedure in patients with challenging periprosthetic hip joint infections.
C1 [Simon, Sebastian; Frank, Bernhard J. H.; Gardete, Susana; Aichmair, Alexander; Mitterer, Jennyfer Angel; Hofstaetter, Jochen G.] Orthopaed Hosp Vienna Speising, Michael Ogon Lab Orthopaed Res, A-1130 Vienna, Austria.
   [Simon, Sebastian; Aichmair, Alexander; Dominkus, Martin; Hofstaetter, Jochen G.] Orthopaed Hosp Vienna Speising, Dept Orthopaed Surg 2, A-1130 Vienaa, Austria.
   [Dominkus, Martin] Sigmund Freud Univ, Sch Med, A-1020 Vienna, Austria.
RP Hofstaetter, JG (通讯作者)，Orthopaed Hosp Vienna Speising, Michael Ogon Lab Orthopaed Res, A-1130 Vienna, Austria.; Hofstaetter, JG (通讯作者)，Orthopaed Hosp Vienna Speising, Dept Orthopaed Surg 2, A-1130 Vienaa, Austria.
EM sebastian.simon@oss.at; bernhard.frank@oss.at; Susana.hartman@oss.at;
   alexander.aichmair@oss.at; JennyferAngel.Mitterer@oss.at;
   martin.dominkus@oss.at; researchlab@oss.at
RI ; simon, sebastian/ACU-0396-2022
OI Frank, Bernhard JH/0000-0002-6193-2413; simon,
   sebastian/0000-0003-1420-4648; Mitterer, Jennyfer/0000-0002-5465-3459;
   Gardete Hartmann, Susana/0009-0009-4872-2997
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NR 43
TC 7
Z9 7
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2021
VL 10
IS 21
AR 5180
DI 10.3390/jcm10215180
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WY8NC
UT WOS:000719533000001
PM 34768700
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gregg, D
   Hiller, L
   Fabri, P
AF Gregg, Desiree
   Hiller, Lynn
   Fabri, Peter
TI The Need to Feed: Balancing Protein Need in a Critically Ill Patient
   With Fournier's Gangrene
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Article
DE necrotizing fasciitis; soft tissue injuries; Fournier gangrene; negative
   pressure wound therapy; acute kidney injury; wound exudate; protein;
   nitrogen balance
ID SOFT-TISSUE INFECTIONS; ACUTE-RENAL-FAILURE; NUTRITION SUPPORT; NITROGEN
   APPEARANCE; GUIDELINES
AB Necrotizing soft tissue injury (NSTI) is rare with an impressively difficult and dangerous clinical course. While the importance of nutrition as part of the treatment plan for NSTI is recognized as essential to recovery, specific recommendations have not been elucidated. A review of the evidence-based guidelines and published research to accomplish wound healing is presented. The nutrition considerations in the setting of organ failure are also discussed. This article outlines a complicated case of a septic, malnourished man with Fournier's gangrene and acute kidney injury. Protein loss from exudate extracted from a negative-pressure vacuum helped estimate the amount of protein needed to accomplish wound healing and guide clinical care. Development of acute kidney injury resulted in protein restriction at the request of the consulting renal service. This restriction led to insufficient protein intake to meet needs required for wound healing as evidenced by a nitrogen balance study and analysis of wound exudate. The estimated daily protein losses through the wound were within 11-26 g protein (2-4 g nitrogen) per day. Inclusion of wound exudate nitrogen loss in nitrogen balance analyses helped resolve conflicting treatment approaches. Estimating protein loss from wound exudate allows for individualization of protein requirements.
C1 [Gregg, Desiree; Hiller, Lynn; Fabri, Peter] James A Haley Vet Hosp, Tampa, FL 33612 USA.
   [Gregg, Desiree] St Josephs Hosp, Tampa, FL USA.
   [Fabri, Peter] Univ S Florida, Tampa, FL USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   James A. Haley Veterans Hospital; State University System of Florida;
   University of South Florida
RP Gregg, D (通讯作者)，James A Haley Vet Hosp, St Josephs Hosp, 3001 W Dr Martin Luther King Jr Blvd, Tampa, FL 33607 USA.
EM dngregg@gmail.com
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NR 27
TC 0
Z9 0
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD DEC
PY 2016
VL 31
IS 6
BP 790
EP 794
DI 10.1177/0884533616651296
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ED2IS
UT WOS:000388667800012
PM 27296812
DA 2026-07-24
ER

PT J
AU Bayer, N
   Hart, WM
   Arulampalam, T
   Hamilton, C
   Schmoeckel, M
AF Bayer, Nicolai
   Hart, Warren Mark
   Arulampalam, Tan
   Hamilton, Colette
   Schmoeckel, Michael
TI Is the Use of BIMA in CABG Sub-Optimal? A Review of the Current Clinical
   and Economic Evidence Including Innovative Approaches to the Management
   of Mediastinitis
SO ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Review
DE CABG; mediastinitis; bilateral; outcomes; costs
ID INTERNAL-THORACIC-ARTERY; STERNAL WOUND-INFECTION; CORONARY-BYPASS
   SURGERY; RISK-FACTORS; DIABETIC-PATIENTS; LONG-TERM; PREVENTION; GRAFTS;
   REVASCULARIZATION; METAANALYSIS
AB Bilateral internal mammary artery (BIMA) in coronary artery bypass grafting (CABG) has traditionally been limited. This review looks at the recent outcome data on BIMA in CABG focusing on the management of risk factors for mediastinitis, one of the potential barriers for more extensive BIMA utilization. A combination of pre-, intra- and postoperative strategies are essential to reduce mediastinitis. Limited data indicate that the incidence of mediastinitis can be reduced using closed incision negative-pressure wound therapy as a part of these strategies with the possibility of offering patients best treatment options by extending BIMA to those with a higher risk of mediastinitis. Recent economic data imply that the technology may challenge the current low uptake of BIMA by reducing the short-term cost differentials between single internal mammary artery and BIMA. Given that most published randomized controlled trials and meta-analyses of observational long-term outcome data favor BIMA, if short-term complications of BIMA including mediastinitis can be controlled adequately, there may be opportunities for more extensive use of BIMA leading to improved long-term outcomes. An ongoing study looking at BIMA in high-risk patients may provide evidence to support the hypothesis that mediastinitis should not be a factor in limiting the use of BIMA in CABG.
C1 [Bayer, Nicolai; Schmoeckel, Michael] Asklepios Klin St Georg, Hamburg, Germany.
   [Hart, Warren Mark; Arulampalam, Tan; Hamilton, Colette] Genesyze, Manchester, Lancs, England.
C3 Asklepios Klinik St. Georg
RP Hart, WM (通讯作者)，Genesyze, iHub, 13th Floor,City Tower,Piccadilly Plaza, Manchester M1 4BT, Lancs, England.
EM warren@genesyze.com
FU Smith Nephew
FX NB and MS are employees of Asklepios Klinik St Georg where the ongoing
   observational mediastinitis study, supported by Smith &Nephew, is being
   carried out; WMH serves as a consultant for Genesyze; and TA and CH are
   directors of Genesyze.
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NR 85
TC 9
Z9 12
U1 0
U2 1
PU Int Acad Publishing Co Ltd
PI Tokyo
PA Academy center, 358-5 yamabukicho, shinjuku-ku, Tokyo, JAPAN
SN 1341-1098
EI 2186-1005
J9 ANN THORAC CARDIOVAS
JI Ann. Thorac. Cardiovasc. Surg.
PY 2020
VL 26
IS 5
BP 229
EP 239
DI 10.5761/atcs.ra.19-00310
PG 11
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA OI2JB
UT WOS:000583110400001
PM 32921659
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Fleming, ME
   O'Daniel, A
   Bharmal, H
   Valerio, I
AF Fleming, Mark E.
   O'Daniel, Anthony
   Bharmal, Husain
   Valerio, Ian
TI Application of the Orthoplastic Reconstructive Ladder to Preserve Lower
   Extremity Amputation Length
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE amputation; soft tissue; length; energy; salvage
ID EXTERNAL TISSUE EXPANDER; EXTRACELLULAR-MATRIX; FREE FLAPS; TRAUMATIC
   AMPUTATIONS; ENERGY-EXPENDITURE; SKIN-GRAFTS; STUMPS; MANAGEMENT;
   AMPUTEES; MODEL
AB Background: A primary goal in traumatic lower extremity amputation management is preservation of limb length. Energy expenditure during ambulation directly correlates with residual limb length, preserved limb segments, and stable joint preservation. An additional factor affecting limb function includes achieving adequate residual limb soft tissue coverage. This report describes techniques for achieving a stable soft tissue envelope to facilitate limb length and joint preservation.
   Methods: A series of traumatic amputation cases with inadequate soft tissue coverage are reviewed. Concepts from the reconstructive surgery ladder were used to achieve residual limb soft tissue coverage and to preserve lower extremity amputation length.
   Results: Soft tissue coverage was accomplished through a series of methods including delayed primary closure with assistance from an external tissue expander, use of acellular dermal regenerative templates combined with split-thickness skin grafting and negative-pressure wound therapy, use of biologic scaffolds such as extracellular porcine urinary bladder matrix combined with delayed skin grafting, and local pedicle flaps or adjacent tissue rearrangements and free tissue transfers.
   Conclusions: The preservation of residual limb length in lower extremity amputations is crucial to optimize prosthetic fitting and to obtain the maximal functional outcome. A series of cases are presented that outline soft tissue coverage options for preserving maximal residual limb length. Applying various concepts from the reconstructive ladder may allow for viable soft tissue coverage to maximize functional outcome.
C1 [Fleming, Mark E.; O'Daniel, Anthony; Bharmal, Husain] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Bethesda, MD 20889 USA.
   [Fleming, Mark E.; Valerio, Ian] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Valerio, Ian] Walter Reed Natl Mil Med Ctr, Plast & Reconstruct Serv, Bethesda, MD USA.
C3 Walter Reed National Military Medical Center; Uniformed Services
   University of the Health Sciences - USA; Walter Reed National Military
   Medical Center
RP Fleming, ME (通讯作者)，Walter Reed Natl Mil Med Ctr, Dept Orthopaed, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM drmefleming@msn.com
RI Fleming, Mark/HJA-3208-2022; Valerio, Ian/F-9161-2017
OI Fleming, Mark/0000-0002-4753-2632; 
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NR 40
TC 27
Z9 36
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD AUG
PY 2014
VL 73
IS 2
BP 183
EP 189
DI 10.1097/SAP.0b013e3182a638d8
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AM8RH
UT WOS:000340144200015
PM 24691339
DA 2026-07-24
ER

PT J
AU Bocchiotti, MA
   Bogetti, P
   Parisi, A
   Rivarossa, F
   Frenello, A
   Baglioni, EA
AF Bocchiotti, M. A.
   Bogetti, P.
   Parisi, A.
   Rivarossa, F.
   Frenello, A.
   Baglioni, E. A.
TI Management of Fournier's gangrene non-healing wounds by autologous skin
   micrograft biotechnology: a new technique
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Fournier gangrene; case study; Rigenera protocol; skin graft;
   non-healing wounds
ID DEHISCENCE
AB Fournier's gangrene is an acute bacterial infection producing necrosis of the perineum and external genitalia that generally affects elderly men. Although skin grafts and flaps are the standard procedure for reconstruction, sometimes wounds can become chronic. Rigenera Protocol is a new technique based on autologous skin micrografts that reactivates and supports wound healing. A 40-year-old male with Fournier's gangrene, due to a rectal microperforation following diarrhoea, was treated with surgical debridement, negative pressure wound therapy and subsequently coverage with skin grafts. He developed non-healing wounds treated by Rigenera protocol after two months of advanced wound dressings. This technique is based on skin micrografts obtained by mechanical dermal disgregation to provide mesenchymal stem cells and extracellular matrix to the wound. The suspension injected into the wound triggers reactivation of healing without significant residual scarring on both donor site and treated area. Non-healing wounds were reduced by 15% at day 7 and by 50% after 30 days. Wounds completely healed after seventy days. The regenerated tissue appeared closer to skin graft than to scar tissue. This report shows how the use of skin micrografts through Rigenera protocol can be a useful method to reactivate wound healing resulting from Fournier's gangrene, with no discomfort for patient in a practical, safe and easy way.
   Declaration of interest: The authors have no conflict of interest.
C1 [Bocchiotti, M. A.; Bogetti, P.; Parisi, A.; Rivarossa, F.; Frenello, A.; Baglioni, E. A.] Univ Turin, Dept Reconstruct & Plast Surg, Citta Salute & Sci Hosp, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; University of Turin
RP Parisi, A (通讯作者)，Univ Turin, Dept Reconstruct & Plast Surg, Citta Salute & Sci Hosp, Turin, Italy.
EM andrea.parisi88@gmail.com
RI /AAM-3165-2021
OI Parisi, Anea/0009-0003-0147-9340
CR Alwaal A, 2015, UROLOGY, V86, P835, DOI 10.1016/j.urology.2015.07.005
   [Anonymous], STEM CELLS INT
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NR 22
TC 9
Z9 13
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2017
VL 26
IS 6
BP 314
EP 317
DI 10.12968/jowc.2017.26.6.314
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EX1TW
UT WOS:000403010300005
PM 28598758
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Geiger, SE
   Deigni, OA
   Watson, JT
   Kraemer, BA
AF Geiger, Scott E.
   Deigni, Olivier A.
   Watson, John Tracy
   Kraemer, Bruce A.
TI Management of Open Distal Lower Extremity Wounds With Exposed Tendons
   Using Porcine Urinary Bladder Matrix
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE lower extremity wounds; surgical wounds; porcine urinary bladder
   extracellular matrix; tissue repair
ID SOFT-TISSUE DEFECTS; NEGATIVE-PRESSURE THERAPY; ACHILLES-TENDON;
   EXTRACELLULAR-MATRIX; RECONSTRUCTION; TRANSFERS; COVERAGE; INTEGRA; FLAP
AB Open wounds of the distal third of the leg and foot with an exposed tendon present a challenge in wound management and in attaining stable, durable coverage. The mobility of the tendon often leads to chronic inflammation that impedes wound closure, while the desiccation of the exposed tendon leads to progressive tendon necrosis. For the authors' cases, the ability of extracellular matrix (ECM) products to modulate wound bed inflammation and facilitate constructive remodeling of a wound seemed a reasonable approach in treating these wounds, especially in patients who are often poor surgical candidates for more advanced reconstructive procedures. Methods. The authors reviewed 13 patients who had open wounds of the distal third of the leg and/or foot that had associated tendon involvement in the wound (Achilles, 6; tibialis anterior, 6; and peroneal, 1). Patients' wounds were treated to total closure. The clinical course and patient management is reviewed herein. Results. The authors found newer ECM products can provide a More optimal method of management of patients with exposed tendons, as compared to prolonged negative pressure wound therapy. Conclusion. Furthermore, the authors conclude the use of newer ECM products yields a more stable, less scarred, reconstructed wound that more closely resembles normal foot and: ankle appearance compared to other more complex reconstructive operative procedures.
C1 [Geiger, Scott E.; Deigni, Olivier A.; Kraemer, Bruce A.] St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
   [Watson, John Tracy] St Louis Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA.
C3 Saint Louis University; Saint Louis University
RP Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.; Kraemer, BA (通讯作者)，St Louis Univ, Sch Med, Div Plast & Reconstruct Surg, Plast Surg, 3635 Vista Ave,3rd Floor Desloge Towers, St Louis, MO 63110 USA.
EM kraemerb@slu.edu
FU ACell Inc
FX Dr. Kraemer participates in the Key Opinion Leaders Bureau for ACell
   Inc, Columbia, MD and has received monies for presenting his clinical
   experience using the porcine urinary bladder matrix-extracellular matrix
   products described in this paper. Dr. Geiger received travel and hotel
   expenses from ACell Inc to present a poster including these clinical
   cases at the Orthopaedic Trauma Association 2014 Annual Meeting in
   Tampa, FL.
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NR 25
TC 26
Z9 31
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2016
VL 28
IS 9
BP 306
EP 316
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DY4FQ
UT WOS:000385054800003
PM 27701126
DA 2026-07-24
ER

PT J
AU Armstrong, DG
   Isaac, AL
   Bevilacqua, NJ
   Wu, SC
AF Armstrong, David G.
   Isaac, Adam L.
   Bevilacqua, Nicholas J.
   Wu, Stephanie C.
TI Offloading Foot Wounds in People with Diabetes
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE diabetic foot ulcer; offloading; total contact casting; review
ID TOTAL CONTACT CASTS; RANDOMIZED CONTROLLED-TRIAL; PLANTAR ULCERATION;
   CLINICAL-TRIAL; HEALING RATES; ULCERS; PRESSURE; MANAGEMENT; WALKERS;
   DEVICES
AB Up to 25% of people with diabetes will develop a foot ulcer at some point during their lifetime, and 1 in 5 will require an amputation. In 2006, more than 65,700 lower-limb amputations were performed in the United States alone in people with diabetes, and the 5-year mortality rate following an amputation is worse than for most malignancies. Along with an interdisciplinary team approach to diabetic limb salvage, "toe and flow," a vertical and horizontal approach to wound healing, is changing the way these patients are cared for. The vertical strategy for wound healing refers to covering important structures and filling defects with negative pressure wound therapy, while the horizontal strategy utilizes skin grafting, bioengineered skin substitutes, and aggressive offloading. The gold standard for offloading foot wounds in people with diabetes is total contact casting, however, recent studies have shown that the modality is seldom used in the current clinical setting. Other offloading devices include removable cast walkers, half shoes, healing sandals, and, more recently, lightweight, rapidly custom-built braces. Offloading of the diabetic foot is often overlooked as a critical part of wound healing, but past experience guides the authors to the conclusion that it is often not what one puts on the wound, but rather what is taken off that primarily affects healing in many of these patients.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, Tucson, AZ 85721 USA.
   [Isaac, Adam L.] Mid Atlantic Permanente Med Grp, Rockville, MD USA.
   [Bevilacqua, Nicholas J.] North Jersey Orthopaed Specialists, Teaneck, NJ USA.
   [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, Chicago, IL USA.
C3 University of Arizona; Permanente Medical Groups; Chicago Medical
   School; Rosalind Franklin University of Medicine & Science
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Tucson, AZ 85721 USA.
EM armstrong@usa.net
RI Isaac, Adam/L-9111-2019
OI Isaac, Adam/0000-0001-5338-3445
CR American Diabetes Association, 1999, DIABETES CARE, V22, P135
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NR 43
TC 14
Z9 22
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JAN
PY 2014
VL 26
IS 1
BP 13
EP 20
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 297PH
UT WOS:000330266900003
DA 2026-07-24
ER

PT J
AU Masson, R
   Parvathala, N
   Ma, E
   Shih, T
   Atluri, S
   Sayed, CJ
   Hogeling, M
   Shi, VY
   Hsiao, JL
AF Masson, Rahul
   Parvathala, Neha
   Ma, Elaine
   Shih, Terri
   Atluri, Swetha
   Sayed, Christopher J.
   Hogeling, Marcia
   Shi, Vivian Y.
   Hsiao, Jennifer L.
TI Efficacy of procedural treatments for pediatric hidradenitis
   suppurativa: A systematic review
SO PEDIATRIC DERMATOLOGY
LA English
DT Review
DE hidradenitis suppurativa; inflammatory disorders; pediatric; procedural
   treatments; systematic review
ID PRESSURE WOUND THERAPY; PHOTODYNAMIC THERAPY; CHILDREN; MANAGEMENT;
   PNEUMOMEDIASTINUM; CRYOINSUFFLATION; EXCISION; INFANTS; LASER
AB Hidradenitis suppurativa (HS) is a painful, inflammatory skin disease that has historically been understudied in the pediatric population. Procedural interventions, such as surgical excisions, skin grafts, and lasers, are important for comprehensive HS disease management. However, there is a lack of data on procedural treatments for HS in pediatric patients. The purpose of this study was to conduct a systematic review of the literature on the efficacy and safety of procedural treatments for HS in pediatric patients. In April 2022, MEDLINE and EMBASE databases were searched for articles on the efficacy of procedural treatments for HS in patients <18 years of age. Two independent reviewers extracted data from relevant studies. From 1974 to 2021, 23 articles with 81 patients were identified. Patients' Hurley stages included stage I (9.1%, 1/11), II (36.4%, 4/11), and III (54.5%, 6/11). The most extensively studied procedural interventions include negative pressure wound therapy (n = 30), surgical excision with skin graft/flap (n = 19), and endoscopic electrode or laser treatment (n = 11). In all, promising response rates for procedural management strategies were observed in the literature but the findings were largely based on case reports/series. Randomized controlled trials (RCTs), especially those geared toward minimally invasive procedural treatments, are needed to help guide clinicians on the most efficacious treatment modalities for pediatric patients with HS.
C1 [Masson, Rahul; Parvathala, Neha; Ma, Elaine] Univ Southern Calif, Keck Sch Med USC, Los Angeles, CA USA.
   [Shih, Terri] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA.
   [Atluri, Swetha] Univ Arizona, Coll Med, Tucson, AZ USA.
   [Sayed, Christopher J.] Univ North Carolina Chapel Hill, Dept Dermatol, Chapel Hill, NC USA.
   [Hogeling, Marcia] Univ Calif Los Angeles, Div Dermatol, Los Angeles, CA USA.
   [Shi, Vivian Y.] Univ Arkansas Med Sci, Dept Dermatol, Little Rock, AR USA.
   [Hsiao, Jennifer L.] Univ Southern Calif, Dept Dermatol, Los Angeles, CA USA.
   [Hsiao, Jennifer L.] USC Dermatol, 1441 Eastlake Ave,Ezralow Tower,Suite 5301, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   University of California System; University of California Los Angeles;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of Southern California
RP Hsiao, JL (通讯作者)，USC Dermatol, 1441 Eastlake Ave,Ezralow Tower,Suite 5301, Los Angeles, CA 90033 USA.
EM j.hsiao.publications@gmail.com
RI ; Sayed, Christopher/AAC-3343-2020; Hsiao, Jennifer/ABB-4999-2020;
   /AAJ-4045-2021
OI Atluri, Swetha/0000-0002-1416-5119; Shi, Vivian/0000-0002-7510-9428;
   Sayed, Christopher/0000-0003-3201-4637; Hsiao,
   Jennifer/0000-0002-8843-3630; 
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NR 56
TC 10
Z9 10
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD JUL
PY 2023
VL 40
IS 4
BP 595
EP 605
DI 10.1111/pde.15331
EA APR 2023
PG 11
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA M5TG4
UT WOS:000974710800001
PM 37092729
OA hybrid
DA 2026-07-24
ER

PT J
AU Formby, P
   Flint, J
   Gordon, WT
   Fleming, M
   Andersen, RC
AF Formby, Peter
   Flint, James
   Gordon, Wade T.
   Fleming, Mark
   Andersen, Romney C.
TI Use of a Continuous External Tissue Expander in the Conversion of a Type
   IIIB Fracture to a Type IIIA Fracture
SO ORTHOPEDICS
LA English
DT Article
ID PRIMARY CLOSURE; WOUND CLOSURE; FASCIOTOMY; TIBIA
AB Various methods have been used for soft tissue coverage of Gustilo-Anderson type IIIB open fractures. These injuries are often contaminated and, by definition, are associated with extensive periosteal stripping and inadequate soft tissue coverage. These characteristics predispose the patient to infection, delayed union, nonunion, and the likelihood of multiple surgeries to achieve durable soft tissue coverage. Although free tissue transfer and rotational flap coverage are the mainstay of treatment for Gustilo-Anderson type IIIB fractures, these procedures typically require additional modalities, such as local wound care, negative-pressure wound therapy, and skin grafting, to expedite wound coverage. Numerous undesirable aspects of these tissue coverage techniques exist, including the requirement for repeated application, potential anesthesia complications, near-constant surveillance, patient compliance, graft failure, and cost. External tissue expanders offer the surgeon a device that can rapidly facilitate closure of full-thickness soft tissue defects. This technique offers the benefit of a 1-time application that is easy to apply and cost-effective and can significantly improve fracture coverage options with a cosmetically acceptable result. Although this technique has been previously described for fasciotomy and ulcer coverage, to the authors' knowledge, continuous external expansion has never been reported in open fracture wound management, specifically in converting type IIIB to type IIIA open fractures. The authors' early success with this method indicates that it may be a valuable tool in the management of Gustilo-Anderson type IIIB open fractures.
C1 [Formby, Peter; Flint, James; Gordon, Wade T.; Fleming, Mark; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Bethesda, MD 20889 USA.
   [Flint, James; Gordon, Wade T.; Fleming, Mark; Andersen, Romney C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
C3 Walter Reed National Military Medical Center; Uniformed Services
   University of the Health Sciences - USA
RP Formby, P (通讯作者)，Walter Reed Natl Mil Med Ctr, Dept Orthopaed, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM p.m.formby.mil@health.mil
RI Fleming, Mark/HJA-3208-2022
OI Fleming, Mark/0000-0002-4753-2632; Andersen, Romney/0009-0000-3507-7612
CR [Anonymous], J PLAST RECONSTR AES
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NR 15
TC 13
Z9 16
U1 1
U2 6
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD FEB
PY 2013
VL 36
IS 2
BP E249
EP E251
DI 10.3928/01477447-20130122-31
PG 3
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 093PW
UT WOS:000315204800019
PM 23383680
DA 2026-07-24
ER

PT J
AU Tschann, P
   Ammann, Y
   Brunner, W
AF Tschann, Peter
   Ammann, Yannic
   Brunner, Walter
TI Management of colorectal anastomotic leakage: from Hartmann's procedure
   to modern endoluminal therapies
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article; Early Access
DE Anastomotic leakage; Complication management; Minimal invasive
   management; Endoscopic negative pressure therapy; Hartmann's Procedure
ID PELVIC SEPSIS
AB PurposeAnastomotic leakage (AL) remains one of the most serious complications in colorectal surgery, with a substantial impact on morbidity, mortality, and long-term oncological outcomes. Although Hartmann's procedure has traditionally been considered the standard approach for managing anastomotic failure, its limitations-particularly the high rates of permanent stoma formation and impaired quality of life-have driven the development of less invasive treatment strategies.MethodsA comprehensive review of the literature was conducted to evaluate current concepts in the pathophysiology, diagnosis, and management of anastomotic leakage following colorectal surgery, with particular emphasis on minimally invasive and endoluminal treatment modalities.ResultsContemporary evidence indicates a shift toward individualized, minimally invasive management strategies tailored to patient condition and leakage severity. Vacuum-assisted and hybrid endoluminal techniques, including vacuum-assisted closure therapy and VAC stent systems, have emerged as promising alternatives to traditional surgical approaches, demonstrating favorable outcomes in selected patients and a potential reduction in long-term morbidity.ConclusionThis comprehensive review summarizes the current understanding of AL pathophysiology, diagnostic principles, and therapeutic strategies, with a special focus on the evolution of vacuum-assisted and hybrid endoluminal techniques such as the VAC stent. Optimal outcomes appear to depend on appropriate patient selection, early diagnosis, interdisciplinary collaboration between surgical and endoscopic teams, and the development of standardized treatment algorithms. Future efforts should focus on refining selection criteria, integrating multimodal expertise, and implementing perioperative optimization strategies.
C1 [Tschann, Peter; Ammann, Yannic; Brunner, Walter] Kantonsspital St Gallen, Dept Gen Visceral Endocrine & Transplant Surg, Hlth Ostschweiz, Rorschacherstr 95, CH-9007 St Gallen, Switzerland.
   [Tschann, Peter] LKH Feldkirch, Dept Gen Visceral & Thorac Surg, Carinagasse 47, A-6800 Feldkirch, Austria.
   [Tschann, Peter] Private Univ Principally Liechtenstein, Dorfstr 26, FL-9495 Triesen, Liechtenstein.
   [Tschann, Peter; Brunner, Walter] Paracelsus Med Univ Salzburg, Dept Surg, Strubergasse 21, A-5020 Salzburg, Austria.
C3 Kantonsspital St. Gallen; Paracelsus Private Medical University
RP Tschann, P (通讯作者)，Kantonsspital St Gallen, Dept Gen Visceral Endocrine & Transplant Surg, Hlth Ostschweiz, Rorschacherstr 95, CH-9007 St Gallen, Switzerland.
EM tschann.pe@gmail.com
RI Tschann, Peter/AAW-8212-2020
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD 2026 MAR 6
PY 2026
DI 10.1007/s10353-026-00936-y
EA MAR 2026
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EX1FZ
UT WOS:001711824600001
DA 2026-07-24
ER

PT J
AU Rajabaleyan, P
   Jensen, RO
   Moeller, S
   Qvist, N
   Ellebaek, MB
AF Rajabaleyan, Pooya
   Jensen, Rie Overgaard
   Moeller, Soeren
   Qvist, Niels
   Ellebaek, Mark Bremholm
TI Primary anastomosis and suturing combined with vacuum-assisted abdominal
   closure in patients with secondary peritonitis due to perforation of the
   small intestine: a retrospective study
SO BMC SURGERY
LA English
DT Article
DE Secondary peritonitis; Vacuum-assisted closure; Anastomotic leakage;
   Enteroatmospheric fistula; Open abdomen
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; NEGATIVE-PRESSURE; SEPSIS;
   MANAGEMENT; FISTULA
AB Background Intestinal resection and a proximal stoma is the preferred surgical approach in patients with severe secondary peritonitis due to perforation of the small intestine. However, proximal stomas may result in significant nutritional problems and long-term parenteral nutrition. This study aimed to assess whether primary anastomosis or suturing of small intestine perforation is feasible and safe using the open abdomen principle with vacuum-assisted abdominal closure (VAC).Methods Between January 2005 and June 2018, we performed a retrospective chart review of 20 patients (> 18 years) with diffuse faecal peritonitis caused by small intestinal perforation and treated with primary anastomosis/suturing and subsequent open abdomen with VAC.Results The median age was 65 years (range: 23-90 years). Twelve patients were female (60%). Simple suturing of the small intestinal perforation was performed in three cases and intestinal resection with primary anastomosis in 17 cases. Four patients (20%) died within 90-days postoperatively. Leakage occurred in five cases (25%), and three patients developed an enteroatmospheric fistula (15%). Thirteen of 16 patients (83%) who survived were discharged without a stoma. The rest had a permanent stoma.Conclusions Primary suturing or resection with anastomosis and open abdomen with VAC in small intestinal perforation with severe faecal peritonitis is associated with a high rate of leakage and enteroatmospheric fistula formation.
C1 [Rajabaleyan, Pooya; Jensen, Rie Overgaard; Qvist, Niels; Ellebaek, Mark Bremholm] Odense Univ Hosp, Univ Southern Denmark, Res Unit Surg, Odense, Denmark.
   [Moeller, Soeren] Univ Southern Denmark, Odense Univ Hosp, Dept Clin Res, OPEN,Open Patient data Explorat Network, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital
RP Rajabaleyan, P (通讯作者)，Odense Univ Hosp, Univ Southern Denmark, Res Unit Surg, Odense, Denmark.
EM Pooya.rajabaleyan@rsyd.dk
RI ; Möller, Sören/X-8738-2019
OI Ellebaek, Mark Bremholm/0000-0001-6550-7505; Rajabaleyan,
   Pooya/0000-0002-6882-9427; Möller, Sören/0000-0003-0858-4269
FU Not applicable.
FX Not applicable.
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NR 37
TC 4
Z9 6
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD SEP 15
PY 2023
VL 23
IS 1
AR 280
DI 10.1186/s12893-023-02179-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA R9OX7
UT WOS:001067583800002
PM 37715227
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wijesooriya, LI
   Waidyathilake, D
AF Wijesooriya, Lakmini Inoka
   Waidyathilake, Dilshan
TI Antimicrobial Properties of Nonantibiotic Agents for Effective Treatment
   of Localized Wound Infections: A Minireview
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE nonantibiotic measures; antibiotic resistance; wound infection;
   diagnosis
ID RESISTANT STAPHYLOCOCCUS-AUREUS; PSEUDOMONAS-AERUGINOSA PAO1; VIRULENCE
   FACTOR PRODUCTION; ZINC-OXIDE NANOPARTICLES; VACUUM-ASSISTED CLOSURE;
   TEA-TREE OIL; ANTIBACTERIAL ACTIVITY; SILVER NANOPARTICLES;
   HYPERBARIC-OXYGEN; BIOFILM FORMATION
AB Wounds present serious health problems in humans and animals. Importantly, if left untreated, wounds invariably lead to long-term morbidity. The inappropriate use and costs of antibiotics place significant challenges globally and affect the health budgets of many countries. Though some antibiotics are administered systemically, treatment of localized infections, in particular, chronic wound infections, does not need such therapy-this would minimize development of antibiotic resistance. Of these measures, nanoparticles of silver, ZnO, and gold seem to give promising results against common wound pathogens while having few limitations. Chemical components of essential oils, which are extracted from different plants, have been shown to act against common wound pathogens. Plant extracts have shown different mechanisms in biofilm elimination. Chlorhexidine and chlorine derivatives act as wound antiseptics. Attempts with biological agents such as maggots have also been shown to provide anti-infective as well as mechanical removal of wound debris. Honey, including those obtained from bees, has a wide coverage against wound pathogens. Glycerin and hypertonic saline are anti-infective through the concentration-dependent killing of pathogens. Hyperbaric oxygen acts against many wound pathogens, in particular anaerobes. This review is focused on nonantibiotic attempts for the cure of localized infections, in particular, chronic wounds with common wound pathogens.
C1 [Wijesooriya, Lakmini Inoka; Waidyathilake, Dilshan] Univ Kelaniya, Kelaniya, Sri Lanka.
C3 University Kelaniya
RP Wijesooriya, LI (通讯作者)，Univ Kelaniya, Fac Med, Dept Med Microbiol, POB 06,Thalagolla Rd, Ragama 11010, Western, Sri Lanka.
EM lakmini.w@kln.ac.lk
OI Wijesooriya, Lakmini Inoka/0000-0001-6449-2321
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   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   Xie YP, 2011, APPL ENVIRON MICROB, V77, P2325, DOI 10.1128/AEM.02149-10
   Zeng XP, 2011, ANTIMICROB AGENTS CH, V55, P3015, DOI 10.1128/AAC.00575-10
   Zhang Z, 2013, INT J MOL MED, V31, P1159, DOI 10.3892/ijmm.2013.1291
   Zhou JW, 2018, J AGR FOOD CHEM, V66, P1620, DOI 10.1021/acs.jafc.7b05035
NR 116
TC 13
Z9 14
U1 0
U2 38
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2022
VL 21
IS 3
BP 207
EP 218
AR 1534734620939748
DI 10.1177/1534734620939748
EA AUG 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3B8DC
UT WOS:000556295200001
PM 32746677
DA 2026-07-24
ER

PT J
AU Vaziri, M
   Jesmi, F
   Pishgahroudsari, M
AF Vaziri, Mohammad
   Jesmi, Fatemeh
   Pishgahroudsari, Mohadeseh
TI Omentoplasty in Deep Sternal Wound Infection
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS;
   CARDIAC-SURGERY; GREATER OMENTUM; MANAGEMENT; TRANSPOSITION; EXPERIENCE
AB Background: The aim of this study was to evaluate retrospectively the results of reconstructing infected post-sternotomy incisions with pedicled omentoplasty.
   Methods: Between March 2009 and December 2012, 15 females (37.5%) and 25 males (62.5%) with an average age of 63 y (range 51-72 y) who were suffering from deep sternal wound infection (DSWI) after coronary artery bypass grafting underwent reconstructive surgery. We evaluated their pre-operative characteristics and post-operative courses.
   Results: Thirty-four of the patients (85%) were found to have DSWI within 1 mo of their cardiac surgery. The mean operative time for the omental flap (OF) procedure was 90 +/- 16.8 min (range 70-135 min). There were three intra-operative complications (7.5%), and post-operative complications occurred in 10 patients (25%). No patient developed any sign of OF necrosis. The median lengths of the post-operative intensive care unit (ICU) and hospital stays were 4 d (range 1-6 d) and 7 d (range 5-14 d), respectively. At the time of discharge, all patients had normal cardiac and mental status.
   Conclusion: We obtained satisfactory outcomes when treating the patients with DSWI by a single-stage OF transposition. On the basis of our experience, we recommend this procedure as an option for patients with DSWI, especially those who are not in a severe low cardiac output state or malnourished.
C1 [Vaziri, Mohammad; Jesmi, Fatemeh; Pishgahroudsari, Mohadeseh] Iran Univ Med Sci, Minimally Invas Surg Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences
RP Vaziri, M (通讯作者)，Iran Univ Med Sci, Rasoul E Akram Hosp, Dept Thorac Surg, Minimally Invas Surg Res Ctr, Niayesh Ave,Sattar Khan St, Tehran, Iran.
EM dr_m_vaziri@yahoo.com
RI Jesmi, Fatemeh/AAI-5593-2021; Vaziri, Mohammad/F-5159-2017
OI Jesmi, Fatemeh/0000-0003-0120-1835; Vaziri, Mohammad/0000-0003-4573-6671
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   Chang RR, 2006, GRABB SMITHS PLASTIC, P665
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NR 22
TC 6
Z9 9
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB 1
PY 2015
VL 16
IS 1
BP 72
EP 76
DI 10.1089/sur.2013.255
PG 5
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA CD0GN
UT WOS:000350748800011
PM 25650746
DA 2026-07-24
ER

PT J
AU Theodorakopoulos, G
   Armstrong, DG
AF Theodorakopoulos, George
   Armstrong, David G.
TI Biofilm in Diabetic Foot Ulcers: A Systematic Narrative Review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
AB Biofilms are a key driver of chronicity and treatment failure in diabetic foot ulcers (DFUs), yet clinical evidence quantifying their impact and management remains fragmented. This systematic narrative review synthesised recent evidence (2015-2025) on the prevalence, diagnostics, and management of biofilm in DFUs. A Systematic Review of the Literature (SRL) was conducted following PRISMA 2020 guidelines across PubMed/MEDLINE, Scopus, Cochrane Library and ScienceDirect. Eligible studies included adults with DFUs reporting biofilm/bioburden metrics or interventions aimed at biofilm disruption. Risk of bias was assessed using RoB 2 for randomised trials and ROBINS-I for non-randomised studies. Data were narratively synthesised by evidence tier (Tier 1 = clinical; Tier 2 = preclinical/mechanistic). Of 600 records screened, 25 studies met inclusion criteria (Tier 1 n = 9; Tier 2 n = 5; reviews n = 11). Over half of bacterial isolates in DFUs were biofilm producers, with multidrug resistance exceeding 90% in several cohorts. Fungi were detected in 31% of ulcers by qPCR but only 9% by culture. Tier 1 clinical evidence supports standard care components-debridement, antiseptics, and negative-pressure wound therapy-for improved healing, though direct antibiofilm outcomes remain limited. Emerging strategies (enzymatic agents, peptides, cold plasma, smart dressings) show promise in vitro but lack clinical translation. Evidence for direct antibiofilm efficacy in DFUs remains scarce. Current data justify maintaining guideline-based care while prioritising trials that integrate validated biofilm endpoints, standardised microbiological methods, and antifungal components. Distinguishing established from experimental approaches is essential to advancing safe, evidence-based biofilm management in DFUs.
C1 [Theodorakopoulos, George] Technol Educ Inst Patras, Patras, Greece.
   [Theodorakopoulos, George] Queen Margaret Univ, Edinburgh, Scotland.
   [Theodorakopoulos, George] Univ West Attica, Aigaleo, Greece.
   [Theodorakopoulos, George] Univ Thessaly, Larisa, Greece.
   [Theodorakopoulos, George] Natl & Kapodistrian Univ Athens, Athens, Greece.
   [Armstrong, David G.] Southwestern Acad Limb Salvage Alliance SALSA, Los Angeles, CA 90033 USA.
   [Armstrong, David G.] Ctr Stream Healthcare Pl C2SHiP, Alexandria, VA USA.
   [Armstrong, David G.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
C3 Western Greece University of Applied Sciences (TEI of Western Greece);
   Queen Margaret University; University of West Attica; University of
   Thessaly; National & Kapodistrian University of Athens; University of
   Southern California
RP Theodorakopoulos, G (通讯作者)，Technol Educ Inst Patras, Patras, Greece.; Theodorakopoulos, G (通讯作者)，Queen Margaret Univ, Edinburgh, Scotland.; Theodorakopoulos, G (通讯作者)，Univ West Attica, Aigaleo, Greece.; Theodorakopoulos, G (通讯作者)，Univ Thessaly, Larisa, Greece.; Theodorakopoulos, G (通讯作者)，Natl & Kapodistrian Univ Athens, Athens, Greece.
EM george_theodorakopoulos@yahoo.gr
RI ; Theodorakopoulos, George/OZD-6104-2025
OI Theodorakopoulos, George/0009-0008-1196-539X; 
FU USC Southwestern Academic Limb Salvage Alliance (SALSA); USC Center to
   Stream Healthcare; Musculoskeletal Medicine at the National and
   Kapodistrian University of Athens
FX The authors thank the USC Southwestern Academic Limb Salvage Alliance
   (SALSA) and the USC Center to Stream Healthcare in Place (C2SHiP) for
   academic inspiration and guidance. G.T. also acknowledges his ongoing
   postgraduate training as an MSc Candidate in Rheumatology and
   Musculoskeletal Medicine at the National and Kapodistrian University of
   Athens, which has enriched his interdisciplinary understanding of
   diabetic foot management.
CR Allkja J, 2025, APMIS, V133, DOI 10.1111/apm.70025
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NR 27
TC 6
Z9 6
U1 5
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC 3
PY 2025
VL 22
IS 12
AR e70795
DI 10.1111/iwj.70795
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA M2723
UT WOS:001630404800001
PM 41339278
OA gold
DA 2026-07-24
ER

PT J
AU Hamaguchi, R
   Wearda, TL
   Volk, AS
   Kramer, KM
   Kimball, AB
   Chaffin, AE
   Orgill, DP
AF Hamaguchi, Ryoko
   Wearda, Taylor L.
   Volk, Angela S.
   Kramer, Kimberly M.
   Kimball, Alexa B.
   Chaffin, Abigail E.
   Orgill, Dennis P.
TI Surgical Management of Hidradenitis Suppurativa: A Two-Center
   Retrospective Study
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID GLUTEAL; RECONSTRUCTION; EXPERIENCE; OUTCOMES
AB Background: Hidradenitis suppurativa is a chronic inflammatory condition that presents a challenging reconstructive problem for plastic surgeons.
   Methods: The authors performed a retrospective chart review of hidradenitis suppurativa patients managed with surgical excision between 2005 and 2020 at Brigham and Women's Hospital and Tulane University Medical Center. Operative cases associated with the same hospitalization were organized into treatment episodes and assessed for patient demographics, operative techniques, and outcomes.
   Results: A total of 181 patients, 435 cases and 316 treatment episodes (Brigham and Women's Hospital, n = 269; Tulane University Medical Center, n = 47), were identified across two diverse institutions. Their respective series showed comparable patient demographics, and 94 percent of the combined episodes achieved wound closure and healing during the study period. Several techniques of closure were identified, including immediate closure and site-specific methods, such as an expedited staged closure using internal negative-pressure wound therapy as a temporary bridge, "recycled" skin grafting, and repurposing iodoform wicks as an adjunct wound healing therapy to immediate closure.
   Conclusions: This large multi-institutional retrospective chart review on the plastic surgical management of hidradenitis suppurativa demonstrates that surgery is an effective therapy for hidradenitis suppurativa and captures a diversity of site-specific techniques that may serve as a foundation for future prospective studies and evidence-based guidelines for the use of various techniques to optimize patients' surgical outcomes. (Plast. Reconstr. Surg. 150: 1115, 2022.)
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.
C1 Harvard Med Sch, Boston, MA 02115 USA.
   Tulane Univ, Div Plast & Reconstruct Surg, Sch Med, New Orleans, LA 70118 USA.
   [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   Beth Israel Deaconess Med Ctr, Dept Dermatol, Boston, MA 02215 USA.
C3 Harvard University; Harvard Medical School; Tulane University; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Beth Israel Deaconess Medical Center
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@bwh.harvard.edu
RI Orgill, Dennis/H-7596-2019
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   Unal C, 2011, MICROSURG, V31, P539, DOI 10.1002/micr.20918
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NR 20
TC 7
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2022
VL 150
IS 5
BP 1115
EP 1127
DI 10.1097/PRS.0000000000009658
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5O9AA
UT WOS:000872755400053
PM 36288254
DA 2026-07-24
ER

PT J
AU Griffin, L
   Casillas, LML
AF Griffin, Leah
   Casillas, Laura M. Leyva
TI A Patient-centered Remote Therapy Monitoring Program Focusing on
   Increased Adherence to Wound Therapy: A Large Cohort Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE remote therapy monitoring; Negative Pressure Wound Theraov; patient
   adherence
AB Objective. This retrospective study of 510 patients receiving negative pressure wound therapy (NPWT) in a home care setting examines the relationship between remote therapy monitoring (RTM) and patient adherence, as well as determines the impact of patient adherence on wound progression. Materials and Methods. Adherence to treatment was continuously monitored via RTM, and patients with therapy usage < 16 hours in 1 day received an adherence call. Repeated failures to reach a noncompliant patient led to an escalation call to the caregiver to discuss treatment. Wound volume and surface area were collected to determine the rate of wound size reduction. Results. A total of 3261 calls were made with an average of 6.4 calls per patient. Among the 510 patients, 98% received a welcome call, 87% received at least 1 call due to low adherence, and 30% received an escalation call. The day following an adherence call, 73.5% of patients increased therapy use. As adherence to NPWT increased (< 60% to 90%-100% therapy use), there was an increase in the daily reduction rate in wound volume (1.42% to 2.23%) and surface area (0.86% to 1.45%). Conclusions. The data suggest RTM can be used to influence patient behavior, and there may be a potential relationship between patient behavior and wound healing outcomes. Additional studies are needed to elucidate the relationship between RTM and wound outcomes.
C1 [Griffin, Leah; Casillas, Laura M. Leyva] Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
RP Griffin, L (通讯作者)，Acelity, 12930 W Interstate 10, San Antonio, TX 78249 USA.
EM Leah.Griffin@Acelity.com
FU KCI, an Acelity Company
FX The authors are employees of Acelity, San Antonio, TX. Financial support
   for this research was provided by KCI, an Acelity Company. Mikaela
   Sifuentes, PhD (Acelity), provided medical writing support. Data were
   presented at the 2018 Symposium on Advanced Wound Care Spring in
   Charlotte, NC.
NR 0
TC 8
Z9 9
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2018
VL 30
IS 8
BP E81
EP E82
PG 2
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7IH
UT WOS:000441910800003
PM 30212369
DA 2026-07-24
ER

PT J
AU Muñoz-Cruzado, VD
   Castro, FJC
   Eguía, AP
   Aguilar, LT
   González, JT
   Puyana, JC
   Ciuró, FP
   Padillo-Ruiz, J
AF Duran Munoz-Cruzado, Virginia
   Calero Castro, Francisco Jose
   Padillo Eguia, Andres
   Tallon Aguilar, Luis
   Tinoco Gonzalez, Jose
   Puyana, Juan Carlos
   Pareja Ciuro, Felipe
   Padillo-Ruiz, Javier
TI Using a bio-scanner and 3D printing to create an innovative custom made
   approach for the management of complex entero-atmospheric fistulas
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PRESSURE WOUND THERAPY; ENTEROATMOSPHERIC FISTULAS; PROLIFERATION;
   EXPERIENCE
AB Enteroatmospheric fistulae are challenging clinical conditions that require surgical expertise and that can result in chronic debilitating conditions placing the patient in a vicious cycle characterized by non healing wounds and malnutrition. They are a complex entity that presents great variability depending on the number, shape, and size of the fistulous orifices, their debit, and the dimensions of the wound. This means that, at present, there is no device that adapts to the anatomical characteristics of each patient and manages to control the spillage of intestinal effluvium from the wound. The aim of this study is to describe the manufacturing technique and to assess the preliminary results of a custom device designed through bioscanner imaging and manufactured using 3D printing for use with negative pressure wound therapy (NPWT) in the management of enteroatmospheric fistula. A proof of concept is given, and the design of the device is presented for the first time. After obtaining images of each fistula with a bioscanner, a personalised device was designed for each patient by 3D printing shape of a prism and a hollow base, taking into account the dimensions of the fistulous area in order to perform a floating ostomy to isolate the wound from the debit enteric. The polycaprolactone (PCL) device was placed including inside the fistulous surface and surrounding it with the NPWT system in order to accelerate wound healing.
C1 [Duran Munoz-Cruzado, Virginia; Calero Castro, Francisco Jose; Tallon Aguilar, Luis; Tinoco Gonzalez, Jose; Pareja Ciuro, Felipe; Padillo-Ruiz, Javier] Virgen Rocio Univ Hosp, Div Gen Surg, Manuel Siurot S-N, Seville 41013, Spain.
   [Padillo Eguia, Andres] Univ Seville, Seville, Spain.
   [Puyana, Juan Carlos] Univ Pittsburgh, Div Surg Crit Care Med & Clin Translat Sci, Pittsburgh, PA USA.
C3 Virgen del Rocio University Hospital; University of Sevilla;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Ciuró, FP (通讯作者)，Virgen Rocio Univ Hosp, Div Gen Surg, Manuel Siurot S-N, Seville 41013, Spain.
EM icirugiaurgenciasHUVR@gmail.com
RI ; Durán Muñoz-Cruzado, Virginia María/GYD-4982-2022; Tallon-Aguilar,
   Luis/JHV-1215-2023; Padillo-Ruiz, Javier/AAF-9792-2021; PAREJA CIURO,
   FELIPE/GZM-1224-2022
OI Puyana, Juan Carlos/0000-0003-4284-4693; Durán Muñoz-Cruzado, Virginia
   María/0000-0003-4499-0483; Tallon-Aguilar, Luis/0000-0002-7549-619X;
   Calero Castro, Francisco José/0000-0002-6039-3091; Padillo-Ruiz,
   Javier/0000-0002-1220-0822; PAREJA CIURO, FELIPE/0000-0001-9192-3465
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NR 28
TC 6
Z9 7
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 16
PY 2020
VL 10
IS 1
AR 19862
DI 10.1038/s41598-020-74213-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OZ9SW
UT WOS:000595259700002
PM 33199726
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Acosta, S
   Monsen, C
   Dencker, M
AF Acosta, Stefan
   Monsen, Christina
   Dencker, Magnus
TI Clinical outcome and microvascular blood flow in VAC®- and
   Sorbalgon®-treated peri-vascular infected wounds in the groin
   after vascular surgery - an early interim analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Groin infection; Laser Doppler blood flow; Negative pressure wound
   therapy; Vacuum-assisted wound closure; Vascular surgery
ID ASSISTED CLOSURE THERAPY; GRAFT INFECTIONS
AB Vacuum-assisted wound closure (VAC (R)) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we performed an early interim analysis of the clinical outcomes in these seriously ill patients at risk of amputation and death. Patients were randomised to either VAC (R) (n = 5) or Sorbalgon (R) (n = 5; best alternative treatment) therapy after surgical debridement. Non-invasive, laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There was no difference in LDPI values in VAC (R) versus Sorbalgon (R) treated patients (P = 0 center dot 46). One patient in the VAC (R) group suffered from two re-bleeding episodes, leading to vascular resection and transfemoral amputation and in the Sorbalgon (R) group two had a complete wound healing time of more than 4 months and one had a visible interposition bypass graft in the groin after 1 month of treatment. No patient died of the groin infection. Although not statistically proven, fewer wound treatment failures were recorded in the VAC (R) group, justifying this early interim analysis. LDPI studies were feasible.
C1 [Acosta, Stefan; Monsen, Christina] Malmo Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
   [Dencker, Magnus] Skane Univ Hosp, Dept Clin Physiol & Nucl Med, Malmo, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Acosta, S (通讯作者)，Malmo Univ Hosp, Vasc Ctr Malmo Lund, SE-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-8895-6001; Acosta, Stefan/0000-0002-3225-0798
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NR 13
TC 14
Z9 16
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 377
EP 382
DI 10.1111/j.1742-481X.2012.00993.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600006
PM 22672773
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Madueke, M
   Lau, F
AF Madueke, Michael
   Lau, Frank
TI Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds
   Following Excision of Hidradenitis Suppurativa Lesions: A Prospective
   Pilot Study
SO POLYMERS
LA English
DT Article
DE tissue regeneration; hidradenitis suppurativa; surgical wound; synthetic
   matrix; synthetic electrospun fiber matrix; skin grafting; infection;
   dermal regeneration; electrospinning
ID OUTCOMES
AB Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates the use of a synthetic electrospun fiber matrix (SEFM) as a post-resection regeneration template to accelerate re-granulation and improve subsequent skin graft incorporation. This prospective pilot study enrolled Hurley Stage II or III patients undergoing surgical resection of HS lesions. SEFM was applied to the resulting wounds in conjunction with negative pressure wound therapy (NPWT). Patients were monitored post-operatively for granulation tissue formation and underwent skin grafting once granulation was sufficient. Skin graft incorporation was assessed at follow-up visits. Complications, including graft loss (partial or complete) and infection, were assessed at each encounter. A total of 21 wounds in eight patients met the inclusion criteria and were enrolled. The average time to skin grafting was 14 +/- 3.2 days. After grafting, the average graft incorporation was 71 +/- 28%. No complications occurred during the study. These initial results indicate that by supporting granulation tissue formation, combined use of SEFM and NPWT may aid in successful engraftment of topographically challenging areas post-HS excision.
C1 [Madueke, Michael] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA.
   [Lau, Frank] Keliomics Inc, 4640 S Macadam Ave, Portland, OR 97239 USA.
   [Lau, Frank] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, Sect Plast & Reconstruct Surg, 1542 Tulane Ave, New Orleans, LA 70112 USA.
C3 Tulane University; Tulane University; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans
RP Lau, F (通讯作者)，Keliomics Inc, 4640 S Macadam Ave, Portland, OR 97239 USA.; Lau, F (通讯作者)，Louisiana State Univ, Hlth Sci Ctr, Dept Surg, Sect Plast & Reconstruct Surg, 1542 Tulane Ave, New Orleans, LA 70112 USA.
EM umadueke@tulane.edu; frankhlau@gmail.com
FU Acera Surgical Inc.; LSU Health Foundation New Orleans
FX This research was funded by Acera Surgical Inc., in the form of an
   unrestricted grant agreement with LSU Health Foundation New Orleans. The
   company was not involved in the study design, collection, analysis,
   interpretation of data, the writing of this article or the decision to
   submit it for publication.
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4360
J9 POLYMERS-BASEL
JI Polymers
PD SEP 23
PY 2025
VL 17
IS 19
AR 2563
DI 10.3390/polym17192563
PG 11
WC Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Polymer Science
GA 8OL7H
UT WOS:001593528000001
PM 41096209
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Veverková, L
   Krejsová, K
   Gerslová, A
   Vlcek, P
   Capov, I
   Reska, M
   Konecny, J
   Urbánek, L
AF Veverkova, L.
   Krejsova, K.
   Gerslova, A.
   Vlcek, P.
   Capov, I.
   Reska, M.
   Konecny, J.
   Urbanek, L.
TI Decubitus as a Cause of Death even in the 21st Century
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE decubitus; risk factors; risk assessment; incidence
ID VACUUM-ASSISTED CLOSURE; WOUNDS
AB Aim: The aim of the study was to analyze the incidence of decubitus in patients hospitalized and undergoing a surgery at the 1st Surgical Clinic (St. Anna's Hospital in Brno) in 2015. Methods: A retrospective analysis of data from the hospital data system and a specific electronic tool (I-hojeni.cz). The statistical software R was used to obtain results of Pearson's Chi-squared test with Yates' continuity correction and statistical significance level of 0.05. Results: The majority of the 3,937 hospitalized patients underwent a surgery (n = 3,431; 86.4%). A newly developed decubitus was detected in 31 patients. The mean age of patients was 82.61 years, the majority were women (18 : 13). Mean body mass index (BMI) was 25.37, mean duration of hospitalization reached 26.67 days. Mean decubitus grade within our group was 1.64. Five patients had more than one decubitus. Decubitus were most frequently located in the area of heel, followed by buttocks area and sacrum. Development of a pressure ulcer was independent of BMI (p > 0.05). There was an association between patient age and development of decubitus (p = 0.02493). Three patients died of decubitus. Conclusion: In spite of implementation of all available preventive measures, decubitus ulcers still occur in surgically treated patients in the 21st century and their treatment is associated with significant financial and time cost.
C1 Masaryk Univ, Fac Med, Surg Clin 1, Brno, Czech Republic.
   St Anne Univ Hosp Brno, Brno, Czech Republic.
C3 Masaryk University; St. Anne's University Hospital Brno (FNUSA)
RP Veverková, L (通讯作者)，Masaryk Univ, St Anne Univ Hosp Brno, Fac Med, Surg Clin 1, Pekarska 53, Brno 60200, Czech Republic.
EM lvever@med.muni.cz
RI Urbánek, Libor/KBC-9913-2024; Konečný, Jan/OSH-7630-2025
OI Urbánek, Libor/0009-0002-2424-1872; Konečný, Jan/0009-0005-5617-4389
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NR 16
TC 1
Z9 1
U1 0
U2 6
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2016
VL 79
SU 1
BP S37
EP S39
DI 10.14735/amcsnn2016S37
PG 3
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA EB5BJ
UT WOS:000387387800008
DA 2026-07-24
ER

PT J
AU Zhang, LX
   Liang, ZJ
   Zhao, BY
   Shi, XW
   Zhang, T
   Liu, H
   Yu, XH
AF Zhang, Li-Xia
   Liang, Zhao-Jun
   Zhao, Bao-Yin
   Shi, Xue-Wen
   Zhang, Tao
   Liu, Hua
   Yu, Xiao-Hui
TI Delayed diagnosis and management of necrotizing fasciitis of the left
   lower leg: A case report
SO MEDICINE
LA English
DT Article
DE case report; multiple organ failure; necrotizing fasciitis; skin
   necrosis; treatment
ID LABORATORY RISK INDICATOR; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; DETERMINANTS; SCORE
AB Introduction: Necrotizing fasciitis (NF) is a rare, severe soft tissue infection, characterized by rapid and extensive necrosis of the skin, subcutaneous tissue, and superficial and deep fascia. It is frequently misdiagnosed as other infectious diseases, leading to inappropriate treatment and potentially serious consequences. It may be complicated by septic shock and multiple organ failure with a fatal outcome. Patient concerns: A 73-year-old woman presented with continuous itching, skin lesions, pain, and swelling of the outer side of her left leg. The patient was diagnosed with septic shock and multiorgan failure caused by left leg NF. Diagnosis: Septic shock and multiorgan failure caused by left leg NF. Interventions: Two surgeries were performed on the patient's leg, which effectively treated her septic shock and multiple organ dysfunction. Outcomes: The patient was followed up three times after her discharge. She had a good recovery, was generally well with no significant sequelae, and returned to her regular life. Conclusion: NF is an acute severe illness with high mortality. It is easily misdiagnosed, leading to delayed or erroneous treatment and serious (or potentially fatal) outcomes. Rapid and accurate diagnosis of NF is essential for patient recovery. In difficult cases, multidisciplinary consultations may be helpful. The management of NF includes early and thorough surgical debridement, antibiotics, and symptomatic treatment.
C1 [Zhang, Li-Xia; Liang, Zhao-Jun; Zhao, Bao-Yin; Yu, Xiao-Hui] 940 Hosp Joint Logist Support Force Chinese Peopl, 333 Nanbinhe Rd, Lanzhou 730050, Gansu, Peoples R China.
   [Zhang, Li-Xia; Liang, Zhao-Jun] Ningxia Med Univ, Clin Med Coll, Yinchuan, Ningxia, Peoples R China.
   [Zhao, Bao-Yin] Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China.
   [Shi, Xue-Wen] Lanzhou Univ, Dept Orthoped, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China.
   [Zhang, Tao; Liu, Hua] 940 Hosp Joint Logist Support Force Chinese Peopl, Orthoped Ctr, Lanzhou, Gansu, Peoples R China.
C3 Ningxia Medical University; Gansu University of Chinese Medicine;
   Lanzhou University
RP Yu, XH (通讯作者)，940 Hosp Joint Logist Support Force Chinese Peopl, 333 Nanbinhe Rd, Lanzhou 730050, Gansu, Peoples R China.
EM yuxiaohui528@126.com
RI Zhao, Baoyin/E-5781-2017
FU Gansu Science and Technology Plan Project (Gansu Clinical Medical
   Research Center for Non-Infectious Liver Disease) [21JR7RA017]
FX Supported by Gansu Science and Technology Plan Project (Gansu Clinical
   Medical Research Center for Non-Infectious Liver Disease), No.
   21JR7RA017.
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   Zhang Z., 2020, INT J INFECT DIS, V14, P316
NR 30
TC 3
Z9 3
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 28
PY 2022
VL 101
IS 43
AR e31231
DI 10.1097/MD.0000000000031231
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5V5UQ
UT WOS:000877294300113
PM 36316936
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Njeze, GE
   Achebe, UJ
AF Njeze, G. E.
   Achebe, U. J.
TI Enterocutaneous fistula: A review of 82 cases
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
DE Enterocutaneous fistula; enteral nutritional support; operative or
   non-operative treatment
ID EXTERNAL FISTULAS; TRACT; MANAGEMENT; NUTRITION
AB Objective: Enterocutaneous fistula is an unpleasant and troublesome complication of abdominal operations. The objective was to review the outcome of treatment of patients treated for enterocutaneous fistula. Materials and Methods: This is a retrospective study of 82 teenage and adult patients, who suffered from enterocutaneous fistula, seen over an 11 year period, in the University of Nigeria Teaching Hospital, Enugu. Patients charts were reviewed for biodata, etiology of the fistula, volume of the fistula output, and result of treatment. Majority of the fistulas occurred after abdominal operations; many by general practitioners. After treatment for correction of fluid and electrolyte deficits, they were all tried on conservative therapy with enteral nutritional support as the main stay of management. Those, whose fistulas did not close, underwent surgical treatment. Total parenteral nutrition, octreotide, fibrin glue, and wound vacuum assisted closure (VAC) were not used for treating these patients. Results: Spontaneous healing of fistulas occurred in 26 patients (31.7%), whereas 42 patients out of 50 (84%) healed after definitive operation. Fourteen patients (17%) in this study, died. Conclusion: Proper management of fluid and electrolyte imbalances, enteral nutritional support, control of sepsis and correctly timed surgical therapy, resulted in this good healing rate and acceptable mortality, without the use of parenteral nutrition, biologic fibrin glue injection or VAC. Suggestions are offered about steps that may help in eradicating some of these enterocutaneous fistulas.
C1 [Njeze, G. E.; Achebe, U. J.] Univ Nigeria, Teaching Hosp, Dept Surg, Ituku Ozala, Enugu, Nigeria.
C3 University of Nigeria
RP Njeze, GE (通讯作者)，Univ Nigeria, Teaching Hosp, Dept Surg, Ituku Ozala, Enugu, Nigeria.
EM iheanaeboagu24@yahoo.com
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   West M.A., 2000, CURR OPIN CRIT CARE, V6, P143
NR 18
TC 11
Z9 16
U1 0
U2 6
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD APR-JUN
PY 2013
VL 16
IS 2
BP 174
EP 177
DI 10.4103/1119-3077.110140
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 248XY
UT WOS:000326740600009
PM 23563457
OA gold
DA 2026-07-24
ER

PT J
AU Kao, AM
   Arnold, MR
   Augenstein, VA
   Heniford, BT
AF Kao, Angela M.
   Arnold, Michael R.
   Augenstein, Vedra A.
   Heniford, B. Todd
TI Prevention and Treatment Strategies for Mesh Infection in Abdominal Wall
   Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID INCISIONAL HERNIA REPAIR; PRESSURE WOUND THERAPY; SYNTHETIC MESH;
   COMPLICATIONS; METAANALYSIS; RECURRENCE; SURGERY; PREDICTORS;
   EXPERIENCE; ENTEROTOMY
AB Background: Mesh infection remains the most feared complication after abdominal wall reconstruction, requiring prolonged hospitalizations and often, mesh removal. Understanding of current prevention and treatment strategies is necessary in the management of a common surgical problem.
   Methods: A comprehensive review of the current surgical literature was performed to determine risk factors of mesh infection after abdominal wall reconstruction and best practices in their prevention and surgical management.
   Results: Patient-related risk factors for mesh infections include smoking, obesity, diabetes mellitus. and COPD. Surgical risk factors such as prolonged operative time and prior enterotomy should also be considered. Prevention strategies emphasize reduction of modifiable risk factors, including obesity and diabetes among other comorbidities. Biologic or biosynthetic mesh is recommended in contaminated fields and use of delayed wound closure or vacuum-assisted closure therapy should be considered in high-risk patients. Conservative treatment with antibiotics, percutaneous or surgical drainage, and negative-pressure vacuum-based therapies have demonstrated limited success in mesh salvage. Mesh infection often requires mesh explantation followed by abdominal wall reconstruction. Staged repairs can be performed; however, definitive hernia repair with biologic mesh has shown promising results.
   Conclusions: Management of mesh infections is a complex, yet commonly faced problem. Strategies used in the prevention and surgical treatment of infected mesh should continue to be supported by high-quality evidence from prospective studies.
C1 [Kao, Angela M.; Arnold, Michael R.; Augenstein, Vedra A.; Heniford, B. Todd] Carolinas Med Ctr, Dept Surg, Div Gastrointestinal & Minimally Invas Surg, Charlotte, NC 28203 USA.
C3 Carolinas Medical Center
RP Heniford, BT (通讯作者)，Carolinas Med Ctr, 1025 Morehead Med Dr,Suite 300, Charlotte, NC 28204 USA.
EM todd.heniford@carolinashealthcare.org
FU Allergan; W. L. Gore; KCI; Stryker
FX Dr. Augenstein has received consultation fees from Allergan, W. L. Gore,
   and KCI. Dr. Heniford has received honoraria, speaker's fees, and
   research support from Allergan, W. L. Gore, and Stryker. These
   disclosures do not impact the topics reported herein. All other authors
   declare no disclosures relevant to this article or research.
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NR 56
TC 104
Z9 120
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2018
VL 142
IS 3
SU S
BP 149S
EP 155S
DI 10.1097/PRS.0000000000004871
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GR7GV
UT WOS:000442857900026
PM 30138283
DA 2026-07-24
ER

PT J
AU Brown, M
   Pourtaheri, N
   Katira, K
   Manjila, S
   Totonchi, AS
AF Brown, Matthew
   Pourtaheri, Navid
   Katira, Kristopher
   Manjila, Sunil
   Totonchi, Ali S.
TI Local Coverage for Acute Severely Herniated Brain Using Scalp and
   Forehead Flaps in a Pediatric Patient With Head Trauma
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Forehead flap; herniated brain; pediatric head trauma; rotational scalp
   flap; subdural hematoma
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; MANAGEMENT; WOUNDS;
   RECONSTRUCTION; CRANIOPLASTY; EXPERIENCE; DURAPLASTY; BONE; DURA
AB A 4-year-old-boy required emergent craniectomy and drainage of a large right-sided acute subdural hematoma after head trauma, during which massive sinus hemorrhage with brain swelling occurred. Acute intraoperative management entailed dural cover using synthetic dural membrane substitute and scalp coverage over the herniated brain using acellular dermal matrix. After intensive monitoring and control of raised intracranial pressure over the next few days, the exposed brain was then covered by scalp and forehead flaps with cadaveric skin grafting to the donor site. This temporary coverage continued until adequate resolution of the intracranial swelling and control of the hydrocephalus using a ventriculoperitoneal shunt. Ultimately, the flaps were derotated and the craniectomy site was reconstructed with autologous banked bone. The child had a significant functional recovery with some residual left-sided weakness. This case is the first report of local tissue flaps used for temporary coverage of malignant brain herniation in a pediatric head trauma patient and highlights their effective use. Through serial surgical procedures the brain was successfully covered without significant blood loss and the patient's local tissues returned to their original donor sites with good cosmetic outcome, without sacrifice of the patient's own skin or free flap options.
C1 [Brown, Matthew; Pourtaheri, Navid; Katira, Kristopher; Totonchi, Ali S.] Case Western Reserve Univ, Div Plast Surg, Metrohlth Med Ctr, 2500 Metrohlth Dr,Towers 9th Floor, Cleveland, OH 44109 USA.
   [Manjila, Sunil] Case Western Reserve Univ, Dept Neurosurg, Metrohlth Med Ctr, Cleveland, OH 44106 USA.
C3 MetroHealth System; University System of Ohio; Case Western Reserve
   University; MetroHealth System; University System of Ohio; Case Western
   Reserve University
EM astotonchi@metrohealth.org
OI Katira, Kris/0000-0002-6157-2710
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NR 18
TC 3
Z9 3
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD JAN
PY 2017
VL 28
IS 1
BP 231
EP 235
DI 10.1097/SCS.0000000000002782
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI2EJ
UT WOS:000392299200053
PM 27922966
DA 2026-07-24
ER

PT J
AU Spartalis, E
   Markakis, C
   Moris, D
   Lachanas, E
   Agathos, EA
   Karakatsani, A
   Karagkiouzis, G
   Athanasiou, A
   Dimitroulis, D
   Tomos, P
AF Spartalis, Eleftherios
   Markakis, Charalampos
   Moris, Demetrios
   Lachanas, Elias
   Agathos, E. Andreas
   Karakatsani, Anna
   Karagkiouzis, Grigorios
   Athanasiou, Antonios
   Dimitroulis, Dimitrios
   Tomos, Periklis
TI Results of the modified bi-pectoral muscle flap procedure for
   post-sternotomy deep wound infection
SO SURGERY TODAY
LA English
DT Article
DE Sternotomy; Bi-pectoral flap; Post-sternotomy mediastinitis
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; MEDIASTINITIS; MANAGEMENT;
   RECONSTRUCTION; THERAPY
AB Purpose Post-sternotomy deep sternal wound infection (DSWI) is a severe complication of cardiac surgery. The introduction of omental and muscle flaps has resulted in a significant decrease in morbidity and mortality. In this article, we present the findings for a series of 55 consecutive patients with DSWI treated using an alternative bi-pectoral musculofascial flap technique.
   Methods The patients were stratified into two groups (one-or two-stage intervention). Patients with septic wounds initially underwent debridement and wound treatment, while vacuum therapy was used in a subset of the subjects. All patients were treated with wound debridement and bi-pectoral advancement flap reconstruction.
   Results 30-day mortality was 5.4 %. Most patients (72 %) were treated in two stages, while vacuum therapy was used in 20 % of the patients. The mean number of hospitalization days was 8 and 12 for the one-and the two-stage groups, respectively. Reconstruction was successful in all but three patients, each of whom developed recurrent infection. No major morbidity was reported at a mean follow-up of 82 months with excellent functional and aesthetic outcomes.
   Conclusions Pectoralis-major muscle flaps remain relevant in the modern management of post-sternotomy mediastinitis. The addition of an omental flap should be considered in cases in which the lower sternum is involved. Prompt diagnosis and a meticulous surgical technique ensure favorable results for the majority of patients.
C1 [Spartalis, Eleftherios; Markakis, Charalampos; Moris, Demetrios; Lachanas, Elias; Agathos, E. Andreas; Karakatsani, Anna; Karagkiouzis, Grigorios; Athanasiou, Antonios; Dimitroulis, Dimitrios; Tomos, Periklis] Univ Athens, Athens Gen Hosp Laikon, Sch Med, Dept Propedeut Surg 2, Agiou Thoma 17, Athens 11527, Greece.
   [Moris, Demetrios] Anastasiou Gennadiou 56, Athens 11474, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital
RP Moris, D (通讯作者)，Univ Athens, Athens Gen Hosp Laikon, Sch Med, Dept Propedeut Surg 2, Agiou Thoma 17, Athens 11527, Greece.; Moris, D (通讯作者)，Anastasiou Gennadiou 56, Athens 11474, Greece.
EM dimmoris@yahoo.com
RI Karakatsani, Anna/J-1862-2019; Spartalis, Eleftherios/W-8936-2018
OI Moris, Dimitrios/0000-0002-5276-0699
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   van Wingerden JJ, 2011, INTERACT CARDIOV TH, V13, P179, DOI 10.1510/icvts.2011.270652
   Vos RJ, 2013, INT WOUND J, V10, P348, DOI 10.1111/j.1742-481X.2012.00989.x
   Vos RJ, 2012, INTERACT CARDIOV TH, V14, P17, DOI 10.1093/icvts/ivr049
   Zor MH, 2014, SURG TODAY, V44, P1476, DOI 10.1007/s00595-013-0737-8
NR 26
TC 12
Z9 14
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD APR
PY 2016
VL 46
IS 4
BP 460
EP 465
DI 10.1007/s00595-015-1192-5
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DI0BH
UT WOS:000373159300011
PM 26026811
DA 2026-07-24
ER

PT J
AU Potter, MJ
   Banwell, P
   Baldwin, C
   Clayton, E
   Irvine, L
   Linge, C
   Grobbelaar, AO
   Sanders, R
   Dye, JF
AF Potter, Matthew J.
   Banwell, Paul
   Baldwin, Christopher
   Clayton, Elizabeth
   Irvine, Laurie
   Linge, Claire
   Grobbelaar, Addrian O.
   Sanders, Roy
   Dye, Julian F.
TI In vitro optimisation of topical negative pressure regimens for
   angiogenesis into synthetic dermal replacements
SO BURNS
LA English
DT Article
DE topical negative pressure; angiogenesis; synthetic dermal replacements
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTIVE SURGERY; ARTIFICIAL SKIN; TISSUE
   DEFECTS; WOUND CONTROL; MATRIX; ALLOGRAFT; INTEGRA; FIBROBLASTS;
   EXPERIENCE
AB Background: The use of synthetic dermal replacements (SDRs) in the treatment of large wounds, which have associated morbidity and mortality, has attracted great interest. However, because of poor outcome, SDRs have limited use. The addition of topical negative pressure (TNP) has increased their success, but little research has focused on the underlying mechanisms. This paper studies the in vitro effects of TNP on commonly used SDRs to identify the most effective TNP regimen and optimum SDR for encouraging endothelial cell ingress.
   Methods: Endothelial cells were co-cultured in vitro on four SDRs with or without TNP. Negative pressure (125 mmHg) was applied intermittently, continuously, for 4 h per day, or not at all. Endothelial ingress was measured for each condition.
   Results: In the collagen controls, cell migration was minimal. Integra (TM) gave the greatest endothelial cell migration (p < 0.05, n = 3). TNP increased endothelial cell migration, intermittent application being the optimum regimen.
   Conclusions: Integra (TM) has an open sponge structure which may account for greater angiogenicity than Alloderm (TM), Permacol (TM) and Xenoder (TM). In vitro intermittent TNP stimulates the greatest angiogenic response. The majority of clinical studies investigating SDR success with TNP have used continuous regimens; this study suggests a change in clinical practice to intermittent application. (c) 2007 Elsevier Ltd and ISBI. All rights reserved.
C1 [Potter, Matthew J.; Baldwin, Christopher; Clayton, Elizabeth; Linge, Claire; Grobbelaar, Addrian O.; Sanders, Roy; Dye, Julian F.] Mt Vernon Hosp, RAFT Inst, Northwood HA6 2RN, Middx, England.
   [Banwell, Paul] Salisbury Dist Gen Hosp, Odstock Burns & Wound Healing Charitable Trust, Salisbury, Wilts, England.
   [Irvine, Laurie] Watford Hosp, NHS Trust, Dept Obstet & Gynaecol, Watford, England.
C3 Salisbury District Hospital; Watford General Hospital
RP Potter, MJ (通讯作者)，43 Queen St, Eynsham OX29 4HH, England.
EM Mattpotters@hotmail.com
RI Dye, Julian Francis/U-3396-2019; Potter, Matthew/JFK-2500-2023;
   Grobbelaar, Adriaan/IUQ-0370-2023
OI Dye, Julian Francis/0000-0001-7634-2822; Grobbelaar,
   Adriaan/0000-0003-2001-5173
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NR 45
TC 25
Z9 32
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2008
VL 34
IS 2
BP 164
EP 174
DI 10.1016/j.burns.2007.06.020
PG 11
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 270DZ
UT WOS:000253701600002
PM 18242874
DA 2026-07-24
ER

PT J
AU Daneshfar, C
   Suryavanshi, J
   Wall, HP
   Cox, C
   MacKay, B
AF Daneshfar, Cy
   Suryavanshi, Joash
   Wall, Hillary Powers
   Cox, Cameron
   MacKay, Brendan
TI Palmar Resurfacing of the Hand With Porcine Urinary Bladder
   Extracellular Matrix Following Traumatic Injury
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE urinary bladder matrix; extracellular matrix; hand injury; traumatic
   wound
ID SOFT-TISSUE COVERAGE; FREE FLAPS; DOMAINS; CELLS
AB Introduction. Complex wounds of the hand often result in soft tissue defects that are not amenable to primary closure, vacuum-assisted closure, or tissue expansion. Injuries presenting with large defects involving multiple levels of tissue must be addressed by using techniques at higher rungs on the reconstructive ladder, such as split-thickness grafting, pedicled flaps, or free flaps. When repairing palmar tissue, these techniques fall short due to their failure to approximate structure and function of specialized skin. More recently, dermal substitutes containing a decellularized extracellular matrix (ECM) have been used in reconstruction of soft tissue defects, acting as a structural scaffold for the regrowth of native cells. Extracellular matrix products have been shown to improve functional and sensory outcomes in areas requiring highly specialized skin. Urinary bladder matrix (UBM), a porcine ECM scaffold, is unique in that it contains an intact epithelial basement membrane that promotes more organized regrowth through layered structure. Case Report. This case presents a novel use of this product in resurfacing 80% of a palm after postoperative necrosis following a table saw injury to the right volar palm at the distal crease. The patient had intact sensation and near normal functional outcomes at most recent follow up. Conclusions. The UBM may be a valuable adjunct to achieve soft tissue coverage in large, complex hand wounds, particularly those involving the palmar surfaces.
C1 [Daneshfar, Cy; Suryavanshi, Joash; Wall, Hillary Powers; Cox, Cameron; MacKay, Brendan] Texas Tech Univ, Dept Orthopaed Surg, Ctr Hlth Sci, 3601 4th St,Mail Stop 9436, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center
RP MacKay, B (通讯作者)，Texas Tech Univ, Dept Orthopaed Surg, Ctr Hlth Sci, 3601 4th St,Mail Stop 9436, Lubbock, TX 79430 USA.
EM brendan.mackay@ttuhsc.edu
OI MacKay, Brendan/0000-0001-7538-2857
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NR 38
TC 3
Z9 4
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2021
VL 33
IS 7
BP E46
EP E52
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WC5GQ
UT WOS:000704285500002
PM 34597269
DA 2026-07-24
ER

PT J
AU Meeker, J
   Weinhold, P
   Dahners, L
AF Meeker, James
   Weinhold, Paul
   Dahners, Laurence
TI Negative Pressure Therapy on Primarily Closed Wounds Improves Wound
   Healing Parameters at 3 Days in a Porcine Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE wound healing; negative pressure therapy; closed wounds
ID VACUUM-ASSISTED CLOSURE; DRAINAGE
AB Objectives: We investigated the role of negative pressure therapy (NPT) in postoperative primary wound treatment and closure. To date, extensive evidence exists demonstrating the benefit of negative pressure dressings in the treatment of open wounds; our experiment tested the hypothesis that negative pressure dressings improve healing of closed (sutured) wounds.
   Methods: A porcine model was used to collect data on the characteristics of closed wounds after 3 days of treatment with NPTs as compared with control dressings.
   Results: In six pigs with a total of 56 wounds, load to failure (N/mm) in controls was 0.348 (standard deviation [SD] 0.109) versus NPT at 0.470 (SD, 0.194) with a P value of 0.001; energy to failure (mJ/mm) in controls was 0.85 (SD, 0.378) versus NPT at 1.128 (SD, 0.638) with a P value of 0.035. Blinded grading of clinical wound appearance and cross-sectional hematoma size were also improved at 72 hours.
   Conclusions: NPT dressings applied to surgically closed wounds enhance the healing characteristics of porcine wounds at 3 days.
   Clinical Relevance: We have observed that primarily closed surgical wounds may benefit from treatment with NPT. The benefit of using NPTs may be most pronounced in situations in which wounds are closed under tension, involve considerable soft tissue trauma, or may be at risk of subdermal hematoma formation.
C1 [Meeker, James; Weinhold, Paul; Dahners, Laurence] Univ N Carolina, Dept Orthopaed, Sch Med, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine
RP Meeker, J (通讯作者)，Univ N Carolina, Dept Orthopaed, Sch Med, CB 7055, Chapel Hill, NC 27599 USA.
EM jmeeker@unch.unc.edu
OI Weinhold, Paul/0000-0002-7307-3580
FU Orthopaedic Trauma Association
FX The study was funded entirely with a $10,000 Resident Research Grant
   from the Orthopaedic Trauma Association.
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NR 14
TC 38
Z9 45
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD DEC
PY 2011
VL 25
IS 12
BP 756
EP 761
DI 10.1097/BOT.0b013e318211363a
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 850OY
UT WOS:000297206200011
PM 22089760
DA 2026-07-24
ER

PT J
AU Pietramaggiori, G
   Liu, P
   Scherer, SS
   Kaipainen, A
   Prsa, MJ
   Mayer, H
   Newalder, J
   Alperovich, M
   Mentzer, SJ
   Konerding, MA
   Huang, S
   Ingber, DE
   Orgill, DP
AF Pietramaggiori, Giorgio
   Liu, Perry
   Scherer, Saja S.
   Kaipainen, Arja
   Prsa, Michael J.
   Mayer, Horacio
   Newalder, Jennifer
   Alperovich, Michael
   Mentzer, Steven J.
   Konerding, Moritz A.
   Huang, Sui
   Ingber, Donald E.
   Orgill, Dennis P.
TI Tensile forces stimulate vascular remodeling and epidermal cell
   proliferation in living skin
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL-CELLS; CHRONIC WOUNDS;
   SHEAR-STRESS; ANGIOGENESIS; MATRIX; GROWTH; SHAPE
AB Objectives: To quantify tissue remodeling induced by static and cyclical application of tensional forces in a living perfused tissue.
   Background: Cells are able to respond to mechanical cues from the environment and can switch between proliferation and quiescence. However, the effects of different regimens of tension on living, perfused skin have not been characterized.
   Methods: The ears of living rats were mechanically loaded by applying tensile forces (0.5 Newtons) either statically or cyclically and then analyzing tissue responses using in vivo microscopy, immunohistochemistry, and corrosion casting.
   Results: Quantitative immunohistochemistry showed that in the static group (4-day continuous tension) there was up to 4-fold increase in cellular proliferation in the epidermis after 4 days and a 2.8-fold increase in the vascularity in the dermis that peaked after 2 days. Comparable effects could be achieved in just 8 hours using a cyclic loading protocol. We also modeled the resultant stress produced in the ear using a linear finite element model and demonstrated a correlation between the level of applied stress and both epidermal cell proliferation and blood vessel density.
   Conclusions: Mechanical forces stimulate cell proliferation and vascular remodeling in living skin. As cell growth and vascular supply are critical to wound healing and tissue expansion, devices applying controlled mechanical loads to tissues may be a powerful therapy to treat tissue defects.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med,Tissue Engn & Wound Healing Lab, Dept Surg,Div Plast Surg, Boston, MA 02115 USA.
   Univ Padua, Dept Plast Surg, I-35100 Padua, Italy.
   Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Surg Childrens Hosp, Boston, MA USA.
   Wentworth Inst Technol, Boston, MA USA.
   Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg,Div Thorac Surg, Boston, MA 02115 USA.
   Univ Mainz Klinikum, Inst Anat, Mainz, Germany.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; University of Padua; Harvard
   University; Harvard Medical School; Harvard University; Harvard Medical
   School; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard Medical School; Johannes Gutenberg
   University of Mainz
RP Orgill, DP (通讯作者)，Harvard Univ, Brigham & Womens Hosp, Sch Med,Tissue Engn & Wound Healing Lab, Dept Surg,Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM doraill@partners.org
RI Mayer, Horacio F/AAE-4645-2020; Orgill, Dennis/H-7596-2019; Ingber,
   Donald/AAC-5894-2019; PIETRAMAGGIORI, Giorgio/HJA-1920-2022
OI Mayer, Horacio F/0000-0002-3586-8657; Orgill,
   Dennis/0000-0002-8279-7310; 
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   STEED DL, 2006, SURG S, V117, pS150
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NR 22
TC 121
Z9 147
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD NOV
PY 2007
VL 246
IS 5
BP 896
EP 902
DI 10.1097/SLA.0b013e3180caa47f
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 229AJ
UT WOS:000250773400029
PM 17968184
DA 2026-07-24
ER

PT J
AU Molina, JE
   Nelson, EC
   Smith, RRA
AF Molina, J. Ernesto
   Nelson, Elaine C.
   Smith, Robin R. A.
TI Treatment of postoperative sternal dehiscence with mediastinitis:
   Twenty-four-year use of a single method
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; POSTSTERNOTOMY
   MEDIASTINITIS; WOUND COMPLICATIONS; MANAGEMENT; STERNOTOMY; TOXICITY;
   CARE
AB Objective: Postoperative deep sternal wound infection with dehiscence carries a high mortality rate, a high morbidity rate, and a poor cure rate. We developed a standard protocol of care to treat this complication, achieving primary closure and cure of the infection.
   Methods: From January 1, 1981, through May 31, 2005 (24 years 5 months), we treated 114 patients with dehiscence and mediastinitis. The diagnosis was made from 4 to 56 days (mean, 14.5 days) after surgery. Mean age was 64.3 years (range, 38-84 years); 79 (69%) were obese, and 48 (42%) had diabetes. Ten had previous attempts (1-4) of repair with other methods. Treatment entailed (1) debridement without removal of bone, (2) bilateral dissection of skin and subcutaneous tissue as one layer, (3) implantation of a staggered double-tube irrigation-suction system posterior and another one anterior to the sternum, (4) lateral reinforcement of the sternum and reclosure with a double wire, and (5) a single-layer closure of the subcutaneous tissue and skin.
   Results: Of 114 patients, 109 (96%) had mediastinitis, positive for Staphylococcus species in 101 (92.6%). The cure rate was 98% (112/114); hospital stay was 14 days (range, 12-16 days), with no deaths.
   Conclusions: Use of this standard protocol is effective and highly recommended. It spares the sternum, cures the infection, and leaves the patient physically functional without the use of soft tissue flaps.
C1 Univ Minnesota, Sch Med, Dept Surg, Div Cardiothorac Surg, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Molina, JE (通讯作者)，Univ Minnesota, Sch Med, Dept Surg, Div Cardiothorac Surg, 420 Delaware St,SE-MMC 107, Minneapolis, MN 55455 USA.
EM molin001@umn.edu
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NR 24
TC 28
Z9 34
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD OCT
PY 2006
VL 132
IS 4
BP 782
EP 787
DI 10.1016/j.jtcvs.2006.06.008
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 090ME
UT WOS:000240954600007
PM 17000288
OA Bronze
DA 2026-07-24
ER

PT J
AU Wenzel, PA
   Rizk, MP
   Michael, A
   Yin, T
   Andrews, BT
AF Wenzel, Piper A.
   Rizk, Michael P.
   Michael, Alexander
   Yin, Terry
   Andrews, Brian T.
TI Assessment of Early and Late Management of Submental Gunshot Wounds
SO FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
LA English
DT Article
DE Craniofacial reconstruction; craniofacial trauma; facial gunshot wounds;
   penetrating trauma; microvascular reconstruction; free tissue transfer
ID INJURIES; RECONSTRUCTION
AB Background: Management of submental gunshot wounds is becoming more common and requires complex surgical decisions. Objective: Compare outcomes of early and definitive reconstructive techniques following submental gunshot wounds. Methods: Retrospective chart review evaluated subjects who sustained a self-inflicted submental gunshot. The incidence of complications requiring unplanned operations was compared for early management techniques of skin/soft tissue, bone, and mucosal lining and definitive reconstructive techniques using Fisher's or Pearson Chi-square exact test with p <= 0.05 considered statistically significant. Results: The total of 27 patients were included. Early techniques included skin = primary soft tissue closure (n = 19) versus wound vacuum-assisted closure (n = 8); mandible = open reduction internal fixation (ORIF) (n = 19) versus external fixation (n = 8); and oral mucosal lining = primary mucosal closure (n = 20) versus dermal substitute (n = 7). Definitive management included ORIF (n = 10, 37%), ORIF with bone grafting (n = 8, 30%), and microvascular free-flap (n = 9, 33%). The incidence of complications requiring unplanned operation when using dermal substitutes for mucosal lining management was statistically higher than primary closure (p < 0.001); otherwise the complication rates of surgical techniques were equivalent. Conclusion: Several surgical decisions and techniques can be utilized at the time of early and definitive management of submental gunshot wounds. Only the use of dermal substitutes for mucosal lining is associated with a significantly higher rate of unplanned operation.
C1 [Wenzel, Piper A.; Rizk, Michael P.; Michael, Alexander; Yin, Terry; Andrews, Brian T.] Univ Iowa Hosp & Clin, Dept Otolaryngol, 200 Hawkins Dr, Iowa, IA 52242 USA.
C3 University of Iowa
RP Andrews, BT (通讯作者)，Univ Iowa Hosp & Clin, Dept Otolaryngol, 200 Hawkins Dr, Iowa, IA 52242 USA.
EM brian-andrews@uiowa.edu
OI Wenzel, Piper/0009-0001-3040-0908
CR Alpert B, 2009, ORAL MAXIL SURG CLIN, V21, P185, DOI 10.1016/j.coms.2008.12.002
   Chrcanovic BR, 2013, ORAL MAXILLOFAC SURG, V17, P95, DOI 10.1007/s10006-012-0349-2
   Demetriades D, 1998, J TRAUMA, V45, P39, DOI 10.1097/00005373-199807000-00007
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   Fowler KA, 2015, PREV MED, V79, P5, DOI 10.1016/j.ypmed.2015.06.002
   Gonzalez-Castro J, 2016, LARYNGOSCOPE, V126, P340, DOI 10.1002/lary.25388
   Heffern E, 2021, J CRANIOFAC SURG, V32, P2487, DOI 10.1097/SCS.0000000000007884
   Khatib B, 2017, FACIAL PLAST SURG CL, V25, P563, DOI 10.1016/j.fsc.2017.06.007
   Li Z, 2011, J CRANIO MAXILL SURG, V39, P296, DOI 10.1016/j.jcms.2010.04.009
   McCann AC, 2019, LARYNGOSCOPE, V129, P1081, DOI 10.1002/lary.27406
   Nevil C, 2021, FACE-THOUSAND OAKS, V2, P329, DOI [10.1177/27325016211053351, 10.1177/27325016211053351]
   Newlands SD, 2003, OTOLARYNG HEAD NECK, V129, P239, DOI 10.1016/S0194-5998(03)00481-9
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   Peleg M, 2010, J CRANIOFAC SURG, V21, P1257, DOI 10.1097/SCS.0b013e3181e2065b
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   Wang WJ, 2015, INT J CLIN EXP MED, V8, P1427
   wisqars, WISQARS fatal and nonfatal injury reports
NR 17
TC 1
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2689-3614
EI 2689-3622
J9 FACIAL PLAST SURG AE
JI Facial Plast. Surg. Aesthet. Med.
PD NOV 1
PY 2024
VL 26
IS 6
BP 786
EP 792
DI 10.1089/fpsam.2023.0359
EA MAY 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N4O7K
UT WOS:001222676700001
PM 38747171
DA 2026-07-24
ER

PT J
AU Blair, JA
   Puneky, GA
   Dickerson, TE
   Faith, HD
   Davis, JM
AF Blair, James A.
   Puneky, George A.
   Dickerson, Thomas E.
   Faith, Hayden D.
   Davis, Jana M.
TI Posttraumatic Soft Tissue Coverage of the Lower Leg for the Orthopedic
   Surgeon
SO ORTHOPEDIC CLINICS OF NORTH AMERICA
LA English
DT Review
DE Rotational flap; Gastrocnemius flap; Soleus flap; Sural flap; Limb
   salvage
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; SOLEUS MUSCLE; SURAL
   FLAP; LOWER-LIMB; RECONSTRUCTION; FOOT; MANAGEMENT; EXTREMITY; DEFECTS
AB Lower extremity trauma care is common with many patients presenting with complex soft tissue injuries. Many orthopedic surgeons perceive such soft tissue injuries to be out of their scope of practice due to presumed complexity and need for microsurgical and vascular reconstructive techniques. In this review, common approaches to treating these injuries and the ease with which these skills may be acquired and executed are discussed. Neither microsurgery nor vascular surgery is required. Methods such as DPWC, NPWT, and piecrusting serve to decrease wound tension and increase rates of successful healing through primary closure. Superficial wound coverage with STSG can provide appropriate coverage in situations in which primary wound closure is unable be obtained. As wound complexity increases, local rotational soft tissue flaps may be necessary to cover exposed bone, tendon, or implants. A multitude of courses are available in the United States and abroad to provide education in wound coverage such as The Surgical Management and Reconstructive Training (SMART) Course, Advanced Techniques in the Management of Soft Tissue (AO North America), and the Soft Tissue Coverage Skills Course (Orthopaedic Trauma Association and Limb Lengthening and Reconstruction Society). The gastrocnemius, soleus, and reverse sural artery rotational flaps prove highly resourceful to the orthopedic surgeon and negate the need for microsurgery or potential delays when working with a multidisciplinary team.
C1 [Blair, James A.; Puneky, George A.; Davis, Jana M.] Augusta Univ, Dept Orthoped Surg, Med Coll Georgia, 1120 15th St,BA 3300, Augusta, GA 30912 USA.
   [Dickerson, Thomas E.; Faith, Hayden D.] Augusta Univ, Med Coll Georgia, 1120 15th St, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University
RP Blair, JA (通讯作者)，Augusta Univ, Dept Orthoped Surg, Med Coll Georgia, 1120 15th St,BA 3300, Augusta, GA 30912 USA.
EM jamblair@augusta.edu
RI Blair, James/MIP-0917-2025
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   Braza ME, 2022, STATPEALS
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   Singh Dishan, 2016, Foot Ankle Spec, V9, P367, DOI [10.1177/1938640015620635, 10.1177/1938640015620635]
   Song P, 2018, ANN PLAS SURG, V81, pS109, DOI 10.1097/SAP.0000000000001499
   Tan O, 2005, MICROSURG, V25, P36, DOI 10.1002/micr.20072
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   Zeiderman MR, 2021, BURNS TRAUMA, V9, DOI 10.1093/burnst/tkab024
NR 35
TC 0
Z9 4
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0030-5898
EI 1558-1373
J9 ORTHOP CLIN N AM
JI Orthop. Clin. North Am.
PD JUL
PY 2022
VL 53
IS 3
BP 297
EP 310
DI 10.1016/j.ocl.2022.03.002
PG 14
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5A2GK
UT WOS:000862710300006
PM 35725038
DA 2026-07-24
ER

PT J
AU Saydam, FA
   Basaran, K
   Ceran, F
   Mert, B
AF Saydam, Funda Akoz
   Basaran, Karaca
   Ceran, Fatih
   Mert, Bulent
TI Foot Ischemia After a Free Fibula Flap Harvest: Immediate Salvage With
   an Interpositional Sapheneous Vein Graft
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Foot ischemia; free fibula flap; salvage
ID MAGNETIC-RESONANCE ANGIOGRAPHY; DONOR-SITE MORBIDITY; MANDIBULAR
   RECONSTRUCTION; COMPARTMENT SYNDROME; LOWER LEG; TRANSPLANTATION;
   VESSELS; HEAD
AB The most dreaded major donor-site complication of free fibula flap is a foot ischemia, which is fortunately rare. Various authors have discussed the efficacy of the use of preoperative imaging methods including color Doppler, magnetic resonance angiography, and conventional angiography. A 25-year-old man presented with a 10-cm mandibular defect after a facial gunshot injury. Lower extremity color Doppler revealed triphasic peroneal, tibialis anterior, and posterior artery flows. A fibula osteocutaneous flap was harvested, and the mandible was reconstructed. However, the suture sites at the donor site began to demonstrate signs of necrosis, abscess formation, and widespread cellulitis beginning from postoperative day 9. Angiogram of the lower extremity on the 13th day demonstrated no flow in the right posterior tibial artery distal to the popliteal artery, whereas the anterior tibial artery had weak flow with collateral filling distally. An emergency bypass with a saphenous vein graft between the popliteal artery and the distal posterior tibial artery was performed. Repeated debridements, local wound care, and vacuum-assisted closure were applied. A skin graft was placed eventually. The extremity healed without severe functional disability. In conclusion, although the arterial anatomy is completely normal in preoperative evaluation, vascular complications may still ocur at the donor fibula free flap site. In addition, emergency cardiovascular bypass surgery, as we experienced, may be necessary for limb perfusion.
C1 [Saydam, Funda Akoz; Basaran, Karaca; Ceran, Fatih] Bagcilar Training & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey.
   [Mert, Bulent] Bagcilar Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkey.
C3 Istanbul Bagcilar Training & Research Hospital; Istanbul Bagcilar
   Training & Research Hospital
RP Basaran, K (通讯作者)，Bagcilar Training & Res Hosp, Dept Plast Surg, Oztopuz Cad Camli Konak, Ulus Besiktas Istanbul, Turkey.
EM basarankaraca@gmail.com
RI Ceran, Fatih/JPK-6708-2023; Mert, Bülent/HLW-5592-2023; Basaran,
   Karaca/AHD-9009-2022
OI Ceran, Fatih/0000-0003-3403-1457; 
CR Ahmad N, 2007, J RECONSTR MICROSURG, V23, P199, DOI 10.1055/s-2007-981500
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   Kelly AM, 2007, AM J ROENTGENOL, V188, P268, DOI 10.2214/AJR.04.1950
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   Ling XF, 2012, PLAST RECONSTR SURG, V129, P657, DOI 10.1097/PRS.0b013e3182402d9a
   Lorenz RR, 2001, HEAD NECK-J SCI SPEC, V23, P844, DOI 10.1002/hed.1123
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   Smith RB, 2003, ARCH OTOLARYNGOL, V129, P712, DOI 10.1001/archotol.129.7.712
   Villarreal PM, 2004, INT J ORAL MAX SURG, V33, P792, DOI 10.1016/j.ijom.2004.01.025
NR 14
TC 6
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD SEP
PY 2014
VL 25
IS 5
BP 1784
EP 1786
DI 10.1097/SCS.0000000000000906
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AP2VK
UT WOS:000341933600087
PM 25119400
DA 2026-07-24
ER

PT J
AU Dobson, MW
   Geisler, D
   Fazio, V
   Remzi, F
   Hull, T
   Vogel, J
AF Dobson, M. W.
   Geisler, D.
   Fazio, V.
   Remzi, F.
   Hull, T.
   Vogel, J.
TI Minimally invasive surgical wound infections: laparoscopic surgery
   decreases morbidity of surgical site infections and decreases the cost
   of wound care
SO COLORECTAL DISEASE
LA English
DT Article
DE Minimally invasive surgery; colorectal surgery; surgical site infections
ID NOSOCOMIAL INFECTIONS; HOSPITALIZATION; SURVEILLANCE
AB Aim
   The morbidity of surgical site infections (SSIs) were compared in patients who underwent open (OS) vs laparoscopic (LS) colorectal surgery.
   Method
   Data from 603 consecutive LS patients and 2246 consecutive OS patients were prospectively recorded. Morbidity of SSIs was assessed by the need for emergency department (ED) evaluation, subsequent hospital re-admission and re-operation. The cost of wound care was measured by the need for home healthcare, wound vacuum assisted closure (VAC) or independent patient wound care.
   Results
   SSIs were identified in 5.8% (n = 25) of LS patients and 4.8% (n = 65) of OS patients. ED evaluation for the infection was needed in 24% of the LS group and 42% of the OS group. Hospital re-admission was needed in one LS patient and in 52% OS patients. No LS patient needed re-operation compared with 12% of OS patients. HHC ($162/dressing change) was required in 63% of the OS group compared with 8% of LS group. A home wound VAC system ($107/day) was utilized in 12% of the OS patients but in none of the LS patients. Dressing changes were managed independently by the patient in 92% of the LS compared with 37% of the OS patients.
   Conclusion
   Laparoscopic colorectal surgery patients experience less morbidity when they develop SSIs incurring less cost compared with open colorectal surgery patients.
C1 [Dobson, M. W.; Geisler, D.; Fazio, V.; Remzi, F.; Hull, T.; Vogel, J.] Cleveland Clin Fdn, Dept Colon & Rectal Surg, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Dobson, MW (通讯作者)，2001 Vail Ave Suite 320, Charlotte, NC 28207 USA.
EM mdobsondo@hotmail.com
RI Remzi, Feza/AAE-6584-2022
CR [Anonymous], SURG INFECT
   Burke JP, 2003, NEW ENGL J MED, V348, P651, DOI 10.1056/NEJMhpr020557
   Casillas S, 2005, DIGEST SURG, V22, P135, DOI 10.1159/000087130
   *CLEV CLIN HOM HLT, EST COSTS HOM HEALTH
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   Zoutman D, 1998, INFECT CONT HOSP EP, V19, P254
NR 16
TC 29
Z9 36
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-8910
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2011
VL 13
IS 7
BP 811
EP 815
DI 10.1111/j.1463-1318.2010.02302.x
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 774QY
UT WOS:000291402400024
PM 20456462
OA Bronze
DA 2026-07-24
ER

PT J
AU Ottomann, C
   Hartmann, B
   Tyler, J
   Maier, H
   Thiele, R
   Schaden, W
   Stojadinovic, A
AF Ottomann, Christian
   Hartmann, Bernd
   Tyler, Josh
   Maier, Heike
   Thiele, Richard
   Schaden, Wolfgang
   Stojadinovic, Alexander
TI Prospective Randomized Trial of Accelerated Re-epithelization of Skin
   Graft Donor Sites Using Extracorporeal Shock Wave Therapy
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ISCHEMIC NECROSIS; WOUNDS; RECRUITMENT;
   INCREASE; ULCERS; FOOT
AB BACKGROUND: Extracorporeal shock wave therapy may enhance revascularization and repair of healing soft tissue.
   METHODS: Between January 2006, and September 2007, 28 patients with acute traumatic wounds and burns requiring skin grafting were randomly assigned in a 1:1 fashion to receive standard topical therapy (nonadherent silicone mesh [Mepitel, Molnlycke Health Care] and antiseptic gel [polyhexanide/octenidine]) to graft donor sites with (n = 13) or without (n = 15) defocused extracorporeal shock wave therapy (ESWT, 100 impulses/cm(2) at 0.1 mJ/mm(2)) applied once to the donor site, immediately after skin harvest. The randomization sequence was computer generated, and the patients were blinded to treatment allocation. The primary endpoint was time to complete donor site epithelialization and was determined by an independent blinded observer.
   RESULTS: Statistical tests indicated no unbalanced distribution of subject characteristics across the two study groups. Mean times to complete graft donor site epithelialization for patients who did and did not undergo ESWT were 13.9 +/- 2.0 days and 16.7 +/- 2.0 days, respectively (p = 0.0001).
   CONCLUSIONS: For centers that apply nonadherent gauze dressings and topical antiseptics to skin graft donor sites, application of a single defocused shock wave treatment immediately after skin graft harvest can significantly accelerate donor site epithelialization. (J Am Coll Surg 2010;211:361-367. (C) 2010 by the American College of Surgeons)
C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
   [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA.
   [Ottomann, Christian; Hartmann, Bernd] Unfallkrankenhaus Berlin, Zentrum Schwerbrandverletzte Plast Chirurg, Berlin, Germany.
   [Maier, Heike] Free Univ Berlin, Klinikum Rudolf Virchow, Robert Rossle Klin, Charite Berlin, D-13122 Berlin, Germany.
   [Thiele, Richard] Int Zentrum Stosswellentherapie, Berlin, Germany.
   [Tyler, Josh] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
   [Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria.
   [Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
C3 Walter Reed National Military Medical Center; United States Department
   of Defense; United States Army; United States Department of Defense;
   United States Army; Walter Reed National Military Medical Center; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; United States Department of Defense; United
   States Army; Brooke Army Medical Center; Uniformed Services University
   of the Health Sciences - USA
RP Stojadinovic, A (通讯作者)，Walter Reed Army Med Ctr, Dept Surg, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA.
EM alexander.stojadinovic@amedd.army.mil
OI Stojadinovic, Alexander/0000-0002-2829-8967
FU Combat Wound Initiative Program, Washington, DC; Internationales Zentrum
   fur Stosswellentherapie, Berlin, Germany
FX Supported, in part, by the Combat Wound Initiative Program, Washington,
   DC and the Internationales Zentrum fur Stosswellentherapie, Berlin,
   Germany.
CR Aicher A, 2006, CIRCULATION, V114, P2823, DOI 10.1161/CIRCULATIONAHA.106.628623
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Arno A, 2010, BURNS
   Davis TA, 2009, INT WOUND J, V6, P11, DOI 10.1111/j.1742-481X.2008.00540.x
   Ennis WJ, 2007, CLIN DERMATOL, V25, P63, DOI 10.1016/j.clindermatol.2006.09.008
   Ennis WJ, 2005, OSTOMY WOUND MANAG, V51, P24
   Huemer GM, 2005, WOUND REPAIR REGEN, V13, P262, DOI 10.1111/j.1067-1927.2005.130308.x
   Ingber DE, 2006, FASEB J, V20, P811, DOI 10.1096/fj.05-5424rev
   Kuo YR, 2007, J SURG RES, V143, P385, DOI 10.1016/j.jss.2006.12.552
   Kuo YR, 2009, WOUND REPAIR REGEN, V17, P80, DOI 10.1111/j.1524-475X.2008.00444.x
   Larking AM, 2010, CLIN REHABIL, V24, P222, DOI 10.1177/0269215509346083
   Moher D, 2001, BMC Med Res Methodol, V1, P2, DOI 10.1186/1471-2288-1-2
   Moretti B, 2009, BMC MUSCULOSKEL DIS, V10, DOI 10.1186/1471-2474-10-54
   Pietramaggiori G, 2007, ANN SURG, V246, P896, DOI 10.1097/SLA.0b013e3180caa47f
   Reichenberger MA, 2009, ANN PLAS SURG, V63, P682, DOI 10.1097/SAP.0b013e31819ae048
   Rennekampff HO, 2006, J BURN CARE RES, V27, P345, DOI 10.1097/01.BCR.0000216311.61266.00
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Schaden W, 2007, J SURG RES, V143, P1, DOI 10.1016/j.jss.2007.01.009
   Stojadinovic A, 2008, ANGIOGENESIS, V11, P369, DOI 10.1007/s10456-008-9120-6
NR 19
TC 67
Z9 70
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD SEP
PY 2010
VL 211
IS 3
BP 361
EP 367
DI 10.1016/j.jamcollsurg.2010.05.012
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 648QH
UT WOS:000281708500009
PM 20800193
DA 2026-07-24
ER

PT J
AU Hunt, NA
   Liu, GT
   Lavery, LA
AF Hunt, Nathan A.
   Liu, George T.
   Lavery, Lawrence A.
TI The Economics of Limb Salvage in Diabetes
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID INTERNATIONAL-WORKING-GROUP; RISK CLASSIFICATION-SYSTEM; VACUUM-ASSISTED
   CLOSURE; LOWER-EXTREMITY ULCERS; FOOT ULCERS; COST-EFFECTIVENESS;
   THREATENING ISCHEMIA; DISEASE MANAGEMENT; PREVENTION PROGRAM; PRIMARY
   AMPUTATION
AB Background: Limb salvage requires early prevention therapy, knowledgeable use of wound care technology, and active management of peripheral vascular disease. This field has changed considerably over the past decade, with new advanced wound healing products and minimally invasive surgery for peripheral vascular disease. Treatment can be very costly in terms of medical and human resources. Evaluation of the clinical and economic impact of medical care is becoming more important as the population with diabetes and the need to contain the cost of health care simultaneously increase. The aim of this study was to review the economic impact of prevention therapies, wound care, and peripheral vascular disease interventions to prevent major lower extremity amputations.
   Methods: The authors reviewed the economic impact of prevention therapy, wound care, and peripheral vascular disease interventions to prevent lower extremity amputations.
   Results: Length of stay in the hospital and intensive care drive the cost of treatment. Surgical intervention and complications for foot ulcers, amputations, and peripheral vascular disease are significant factors in the cost of limb salvage.
   Conclusions: Not surprisingly, prevention and evidenced-based treatments are the most cost-effective way of reducing the use of medical resources and improving and prolonging productive lifestyles. Future prospective studies need to be conducted to more accurately understand the financial impact of limb salvage. (Plast. Reconstr. Surg. 127 (Suppl.): 289S, 2011.)
C1 [Lavery, Lawrence A.] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
   Univ Texas SW Med Ctr Dallas, Dept Orthopaed Surg, Dallas, TX 75390 USA.
   Univ Texas SW Med Ctr Dallas, Ctr Rockies, Dallas, TX 75390 USA.
   Parkland Hosp, Ft Collins, CO USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center; University of Texas System; University of Texas
   Southwestern Medical Center
RP Lavery, LA (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM lklavery@yahoo.com
RI Liu, George/KBA-8591-2024
OI Lavery, Lawrence/0000-0002-7920-9952; Hunt, Nathan/0000-0002-1092-8246
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   Ashry H R, 1998, J Foot Ankle Surg, V37, P186
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   Tennvall GR, 2001, DIABETOLOGIA, V44, P2077
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
   Wieman TJ, 1998, DIABETES CARE, V21, P822, DOI 10.2337/diacare.21.5.822
NR 40
TC 32
Z9 36
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2011
VL 127
IS 1
SU S
BP 289S
EP 295S
DI 10.1097/PRS.0b013e3181fbe2a6
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 705IP
UT WOS:000286122400040
PM 21200304
DA 2026-07-24
ER

PT J
AU Wainstein, DE
   Tüngler, V
   Ravazzola, C
   Chara, O
AF Wainstein, Daniel E.
   Tuengler, Victoria
   Ravazzola, Constanza
   Chara, Osvaldo
TI Management of external small bowel fistulae: Challenges and
   controversies confronting the general surgeon
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Review
DE Small bowel; Enterocutaneous fistula; Sub-atmospheric pressure
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE ENTEROCUTANEOUS FISTULAS;
   ABDOMINAL-WALL DEFECTS; GASTROINTESTINAL FISTULAS; RECONSTRUCTIVE
   SURGERY; EXPERIENCE; REPAIR; CLASSIFICATION; RECURRENCE; OCTREOTIDE
AB Background: External small bowel fistulae (ESBF) are serious complications that represent a major challenge for general surgeons. They are still associated with significant morbidity and mortality. This article reviews the management of ESBF with emphasis on the treatment using sub-atmospheric pressure as well a timing, strategies and techniques of reconstructive surgery.
   Methods: Relevant articles from 1960 to 2010 were identified using various electronic databases to review randomized controlled trials, prospective observational studies, retrospective studies and case reports and highlight key references.
   Conclusions: External small bowel fistulae require multidisciplinary management and multimodal approaches with a primary essential focus on early recognition and diminishment of mortality factors such as sepsis and malnutrition. In most cases, the initial treatment is conservative, including clinical and nutritional recovery, output control and extensive local wound care. At this stage, the application of local negative pressure is highly effective. This procedure also allows for a spontaneous closure in many patients. Other cases require careful consideration of surgical reconstruction, knowing that success rates are variable and largely dependent on the patient's condition as well as on local aspects of the lesion. Best surgical results are obtained via intra-peritoneal access with extensive enterolysis, resection of the bowel segment from which the fistulae originate and direct abdominal wall closure. (C) 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Wainstein, Daniel E.] Hosp E Tornu, Buenos Aires, DF, Argentina.
   [Tuengler, Victoria] Charite Univ Med Berlin, Berlin, Germany.
   [Ravazzola, Constanza; Chara, Osvaldo] Univ Buenos Aires, Fac Med, Dept Fisiol & Biofis, Buenos Aires, DF, Argentina.
   [Chara, Osvaldo] CIC, UNLP, CONICET, Inst Fis Fluidos Sistemas Biol IFLYSIB, La Plata, Argentina.
   [Chara, Osvaldo] Tech Univ Dresden, Ctr Informat Serv & High Performance Comp, D-01062 Dresden, Germany.
C3 University of Buenos Aires; University of Buenos Aires Hospital; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Buenos Aires; National
   University of La Plata; Consejo Nacional de Investigaciones Cientificas
   y Tecnicas (CONICET); Technische Universitat Dresden
RP Wainstein, DE (通讯作者)，Hosp E Tornu, Buenos Aires, DF, Argentina.
EM dwainstein@telered.com.ar
RI Tüngler, Victoria/AAA-2396-2022; Chara, Osvaldo/T-2798-2019
OI Tüngler, Victoria/0000-0003-3486-2824; Chara,
   Osvaldo/0000-0002-0868-2507
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NR 58
TC 6
Z9 8
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 3
BP 198
EP 203
DI 10.1016/j.ijsu.2010.11.009
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 832BL
UT WOS:000295775300003
PM 21111073
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Mouës, CM
   van Toorenenbergen, AW
   Heule, F
   Hop, WC
   Hovius, SER
AF Moues, Chantal M.
   van Toorenenbergen, Albert W.
   Heule, Freerk
   Hop, Wim C.
   Hovius, Steven E. R.
TI The role of topical negative pressure in wound repair:: Expression of
   biochemical markers in wound fluid during wound healing
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; MATRIX-METALLOPROTEINASES;
   DIFFERENTIAL EXPRESSION; TISSUE INHIBITOR; THERAPY;
   MATRIX-METALLOPROTEINASE-9; ANGIOGENESIS; PROTEASES; ELASTASE
AB The clinical effects of topical negative pressure therapy (TNP) on wound healing are well described in numerous articles. While the mechanism(s) of action are not completely understood, it is postulated that reduction of local and interstitial tissue edema, increased perfusion of the (peri-) wound area, changed bacterial composition, and mechanical stimulation of the woundbed contribute to the clinical success. Our hypothesis is that with the removal of excessive fluid, proteolytic enzymes negatively influencing the healing process are removed. Our aim was to assess whether the concentrations of albumin, matrixmetalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase (TIMP-1) were different between wounds treated with TNP and conventional gauze therapy. We analyzed wound fluid samples of 33 wounds treated with either TNP therapy (n=15) or conventional therapy (n=18) on albumin, pro- and activated MMP-9, TIMP-1, and the ratio of total MMP-9/TIMP-1. Albumin levels were found to increase significantly in acute wounds compared with chronic wounds; however, no difference could be found on comparing TNP with conventional therapy. We did find significantly lower levels of pro-MMP-9 and lower total MMP-9/TIMP-1 ratio in TNP-treated wounds during the follow-up of 10 days. These data strongly suggest that TNP therapy influences the microenvironment of the wound.
C1 [Moues, Chantal M.; Hovius, Steven E. R.] Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, NL-3000 CA Rotterdam, Netherlands.
   [van Toorenenbergen, Albert W.] Erasmus Univ, Med Ctr, Dept Clin Chem, NL-3000 CA Rotterdam, Netherlands.
   [Heule, Freerk] Erasmus Univ, Med Ctr, Dept Dermatol, NL-3000 CA Rotterdam, Netherlands.
   [Hop, Wim C.] Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC
RP Mouës, CM (通讯作者)，Erasmus Univ, Med Ctr, Dept Plast Reconstruct & Hand Surg, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM cmoues@hotmail.com
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NR 35
TC 62
Z9 71
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2008
VL 16
IS 4
BP 488
EP 494
DI 10.1111/j.1524-475X.2008.00395.x
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 326RF
UT WOS:000257675900004
PM 18638266
DA 2026-07-24
ER

PT J
AU Harder, Y
   Krapf, J
   Rieck, B
   Schaefer, DJ
   Djedovic, G
   Kutschka, I
   Graf, K
   Kneser, U
   Horch, RE
   Lehnhardt, M
   Pierer, G
AF Harder, Yves
   Krapf, Johanna
   Rieck, Bernd
   Schaefer, Dirk J.
   Djedovic, Gabriel
   Kutschka, Ingo
   Graf, Karolin
   Kneser, Ulrich
   Horch, Raymund E.
   Lehnhardt, Marcus
   Pierer, Gerhard
TI Deep sternal wound infection after sternotomy Report of the consensus
   workshop of the German-Speaking Society for Microsurgery of Peripheral
   Nerves and Vessels (DAM)
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Article
DE Pedicled flaps; free flaps; infection; Sternum
ID FREE-FLAP RECONSTRUCTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   CARDIAC-SURGERY; MANAGEMENT; COMPLICATIONS; DEFECTS; PREDICTORS;
   EXPERIENCE; STABILITY
AB Zusammenfassung Der tiefe sternale Wundinfekt (TSWI) ist eine seltene Komplikation nach Sternotomie, die mit hoher Morbiditat und Mortalitat behaftet ist und Krankenhausaufenthalt sowie die Behandlungskosten signifikant ansteigen lasst. Eine mikrobiologische Besonderheit ist die Ausbildung von Biofilmen auf Implantatmaterial und/oder Knochensequestern. Die Diagnose wird anhand der klinischen Symptomatik der lokalen Entzundungsreaktion gestellt und durch systemische Infektionszeichen gestutzt. Eine fruhzeitige und gemeinsame Konsensfindung, welche die oft interdisziplinare Behandlungsstrategie festlegt, ist dabei essenziell. Die Behandlung besteht i.d.R.aus mehreren chirurgischen Wunddebridements mit zwischenzeitlicher Wundkonditionierung, bis ein ausreichend sauberer Wundstatus erreicht ist. Zur Infektsanierung und fur den Wundverschluss stehen je nach Gro ss e und Lokalisation des Gewebedefektes eine Vielzahl verschiedener gestielter und freier Lappenplastiken zur Auswahl.
   Abstract Deep sternal wound infection (TSWI) is a potentially life-threatening complication that may occur after median sternotomy, contributing to prolonged hospital stay and increased health care costs. Bacterial infection is often characterized by biofilm formation on implant material and/or dead bone. Diagnosis is made upon clinical signs and symptoms of local and systemic infection. Early multidisciplinary decision making is needed for optimal patient care. Repeated surgical wound debridements accompanied by wound conditioning are performed until clean circumstances are achieved. Thereafter, wound closure and defect reconstruction are obtained using a variety of pedicled and microvascular flaps.
C1 [Harder, Yves] Ente Osped Cantonale EOC, Osped Reg Lugano ORL, Klin Plast Rekonstrukt & Asthet Chirurg, Lugano, Switzerland.
   [Harder, Yves] Univ Svizzera Italiana, Fac Biomed Sci, Lugano, Switzerland.
   [Krapf, Johanna; Pierer, Gerhard] Med Univ Innsbruck, Univ Klin Plast Rekonstrukt & Asthet Chirurg, Innsbruck, Austria.
   [Rieck, Bernd] Kaiser Friedrich Str, Hildesheim, Germany.
   [Schaefer, Dirk J.] Univ Spital Basel, Klin Plast Rekonstrukt Asthet & Handchirurg, Basel, Switzerland.
   [Djedovic, Gabriel] Landekrankenhaus Feldkirch, Abt Plast Rekonstrukt & Asthet Chirurg, Feldkirch, Australia.
   [Kutschka, Ingo] Univ Med Gottingen, Klin Thorax Herz & Gefasschirurg, Gottingen, Germany.
   [Graf, Karolin] Paracelsus Kliniken Deutschland, Zent Inst Krankenhaushyg, Langenhagen, Germany.
   [Kneser, Ulrich] Heidelberg Univ, Klin Hand Plast & Rekonstrukt Chirurg, Berufsgenossenschaftl Unfallklin Ludwigshafen, Schwerbrandverletztenzentrum,Klin Plast & Handchi, Heidelberg, Germany.
   [Horch, Raymund E.] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Erlangen, Germany.
   [Lehnhardt, Marcus] BG Univ Klinikum Bergmannsheil Bochum, Klin Plast Chirurg & Handchirurg, Schwerbrandverletztenzentrum, Bochum, Germany.
C3 Universita della Svizzera Italiana; Medical University of Innsbruck;
   University of Basel; Ruprecht Karls University Heidelberg; University of
   Erlangen Nuremberg; Ruhr University Bochum
RP Harder, Y (通讯作者)，Ente Osped Cantonale EOC, Osped Reg Lugano ORL, Klin Plast Rekonstrukt & Asthet Chirurg, CH-6962 Viganello Lugano, Switzerland.
EM yves.harder@eoc.ch
RI ; Schaefer, Dirk/I-9806-2018; Horch, Raymund E/H-8128-2019
OI Kutschka, Ingo/0000-0002-7358-3513; Harder, Yves/0000-0002-2557-249X;
   Horch, Raymund E/0000-0002-6561-2353
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NR 46
TC 3
Z9 3
U1 0
U2 7
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD DEC
PY 2021
VL 53
IS 06
BP 519
EP 525
DI 10.1055/a-1425-5987
EA MAY 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XK7ZA
UT WOS:000647258000001
PM 33951736
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Al Zarouni, M
   Trelles, MA
   Leclère, FM
AF Al Zarouni, Marwan
   Trelles, Mario A.
   Leclere, Franck M.
TI Abdominal wall reconstruction with Two-step Technique (TST): a
   prospective study in 20 patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Abdominal wall defect; Compartment syndrome; Inner layer reconstruction;
   VAC
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; COMPONENT SEPARATION; DEFECTS;
   MANAGEMENT; ANATOMY; SYSTEM; HERNIA; WOUNDS; TRIAL
AB Abdominal wall defects continue to be a challenging problem for reconstructive surgeons. The aim of our study was to report a 3-year experience using a simple Two-step Technique (TST) to treat abdominal wall defects. Between January 2008 and December 2010, 20 patients with abdominal wall defects were treated by TST. Patients had a mean age of 375 +/- 149years (range: 22-85years); 5 were women and 15 were men. The size of the defects was prospectively analysed. Early and late complications were recorded. Hospital stay, post-procedure downtime and patient overall satisfaction were systematically assessed. A secondary defect resulting from self-manipulation and an infection were responsible for a complication rate of 10%. Both underwent successful surgical revision which led to full resolution. The average hospital stay was 112 +/- 49weeks for the series. Long-term complications were scar hyperpigmentation in 11 cases, scar hypertrophy in 5 cases and scar widening in 3 cases. Mean patient satisfaction was 83 +/- 05 [visual analogue scale (VAS) 0-10]. Average downtime post surgery was 41 +/- 12weeks. The mean follow-up was 246 +/- 67months. Reconstruction of abdominal wall defect with the TST is a reliable and reproducible technique. This technique provides excellent outcomes, and we anticipate that it will become widespread in the near future.
C1 [Al Zarouni, Marwan] Rashid Univ Hosp Dubai, Dept Plast & Reconstruct Surg, Dubai, U Arab Emirates.
   [Trelles, Mario A.] FDN ANTONI DE GIMBERNAT, Inst Med Vilafortuny, Cambrils, Spain.
   [Leclere, Franck M.] Univ Bern, Inselspital Bern, Dept Plast Surg & Handsurg, CH-3008 Bern, Switzerland.
C3 University of Bern; University Hospital of Bern
RP Leclère, FM (通讯作者)，Univ Bern, Inselspital Bern, Dept Hand & Plast Surg, Freiburgstr, CH-3008 Bern, Switzerland.
EM franckleclere@yahoo.fr
OI leclère, franck marie/0000-0002-6717-0368
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   Zingg U, 2009, WORLD J SURG, V33, P1334, DOI 10.1007/s00268-009-9965-x
NR 28
TC 6
Z9 6
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 173
EP 178
DI 10.1111/iwj.12075
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400010
PM 23786231
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Blok, CS
   Vink, L
   de Boer, EM
   van Montfrans, C
   van den Hoogenband, HM
   Mooij, MC
   Gauw, SA
   Vloemans, JAFPM
   Bruynzeel, I
   van Kraan, A
   Kuik, J
   Waaijman, T
   Scheper, RJ
   Gibbs, S
AF Blok, Chantal S.
   Vink, Liselot
   de Boer, Edith M.
   van Montfrans, Catherine
   van den Hoogenband, Henk M.
   Mooij, Michael C.
   Gauw, Stefanie A.
   Vloemans, Jos A. F. P. M.
   Bruynzeel, Ineke
   van Kraan, Aleid
   Kuik, Joop
   Waaijman, Taco
   Scheper, Rik J.
   Gibbs, Susan
TI Autologous skin substitute for hard-to-heal ulcers: Retrospective
   analysis on safety, applicability, and efficacy in an outpatient and
   hospitalized setting
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VENOUS LEG ULCERS; DIABETIC FOOT ULCERS; KERATINOCYTES; INSUFFICIENCY;
   FIBROBLASTS; APLIGRAF(R); MULTICENTER; THERAPY
AB Chronic ulcers ((arterio)venous, decubitus, or postoperative) have no tendency to heal within a period of at least 3 months despite optimal therapy according to internationally accepted guidelines. This retrospective study evaluates the safety and efficacy of an autologous, dermal-epidermal skin substitute (SS) for treating ulcers of various origins. Ulcers were treated within 7 Dutch centers over 5 years. Sixty-six ulcers (size: 0.75-150cm(2); duration: 0.25-32 years) with a follow-up time of 24 weeks after a single-skin substitute application were assessed. Wound-bed preparation consisted of vacuum-assisted-closure-therapy (5 days, hospitalized) or application of acellular dermis (5-7 days, outpatient). Time to heal, adverse events, and recurrence 1 year after complete healing were recorded. Complete ulcer healing occurred in 36 of 66 ulcers (55%) at 24 weeks. At that time point, a further 29% of ulcers showed decrease in ulcer size between 50 and 99%. No difference was observed between the hospitalized vs. outpatient treatment with complete healing. There were 32 of 36 healed ulcers that were available for follow-up 1 year after complete closure, of which 27 (84%) were still closed. Only two minor/moderate possibly related adverse events were recorded. This retrospective analysis shows that SS provides a safe and successful treatment for particularly chronic ulcers of various origins.
C1 [Blok, Chantal S.; Vink, Liselot; de Boer, Edith M.; van Montfrans, Catherine; van den Hoogenband, Henk M.; Waaijman, Taco; Gibbs, Susan] Vrije Univ Amsterdam Med Ctr, Dept Dermatol, Amsterdam, Netherlands.
   [Kuik, Joop] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Scheper, Rik J.] Vrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands.
   [Gibbs, Susan] Acad Ctr Dent Amsterdam ACTA, Amsterdam, Netherlands.
   [Mooij, Michael C.; Gauw, Stefanie A.] Ctr Oosterwal, Alkmaar, Netherlands.
   [Vloemans, Jos A. F. P. M.] Red Cross Hosp, Beverwijk, Netherlands.
   [Bruynzeel, Ineke] Groene Hart Hosp, Gouda, Netherlands.
   [van Kraan, Aleid] Waterland Hosp, Purmerend, Netherlands.
C3 Vrije Universiteit Amsterdam; Amsterdam University Medical Center; Vrije
   Universiteit Amsterdam; Amsterdam University Medical Center; Vrije
   Universiteit Amsterdam; Amsterdam University Medical Center; University
   of Amsterdam; Vrije Universiteit Amsterdam
RP Gibbs, S (通讯作者)，Vrije Univ Amsterdam Med Ctr, Dept Dermatol, De Boelelaan, NL-1081 HV Amsterdam, Netherlands.
EM s.gibbs@vumc.nl
OI Waaijman, Taco/0009-0002-8661-657X
FU VU University medical centre, LPC grant best practices; Biopartner First
   Stage Grant [807.05.217]; A-Skin Nederland BV (a spin-off tissue
   engineering company of VU University Medical Centre)
FX This study was in part financed by VU University medical centre, LPC
   grant best practices 2007, Biopartner First Stage Grant, project
   807.05.217 and A-Skin Nederland BV (a spin-off tissue engineering
   company of VU University Medical Centre).
CR Auger FA, 2009, SKIN PHARMACOL PHYS, V22, P94, DOI 10.1159/000178868
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   Kirsner RS, 2012, LANCET, V380, P977, DOI 10.1016/S0140-6736(12)60644-8
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   Zaulyanov L, 2007, CLIN INTERV AGING, V2, P93, DOI 10.2147/ciia.2007.2.1.93
NR 34
TC 15
Z9 19
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 667
EP 676
DI 10.1111/wrr.12082
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300004
PM 23926998
DA 2026-07-24
ER

PT J
AU Kumar, P
   Sharma, A
AF Kumar, Pramod
   Sharma, Ankur
TI The Limited Access Dressing for Damage Control in Trauma Patients
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; OPEN CELL FOAM;
   MANAGEMENT
AB The leeching effects of the Limited Access Dressing (LAD) effectively controls infection, reduces edema, promotes earlier physiotherapy, and helps to control secondary damage to trauma cases, which results in faster wound bed preparation reconstruction, and quicker rehabilitaion The following is a case series of 20 consecutive patients treated with LAD without specific controls. In eight cases bone was exposed in three cases tendon was exposed, in two cases both bone and tendon were exposed, and in one case an injured brachial artery was exposed Methods After saline wash, the LAD with intermittent negative pressure was applied (30 minutes negative pressure, 3 5-hour rest period) Wound debridement and physiotherapy were started on day 1 as necessary Second stage elective procedure was done after healthy granulation tissue had covered exposed tendon bone, and vessels. A split-thickness skin graft (SSG) was then applied to cover the wound Results Excellent graft take (> 99%) was seen in 18 of the 20 cases where skin grafting was done under LAD The time taken to prepare the wound for resurfacing (after skin grafting) was less than 6 weeks in the majority (16/18) of cases Post discharge physiotherapy to achieve maximum possible mobilization in upper extremity (10/20) cases was less than 6 weeks in most cases (6/10) The average cost of treatment was Rs 16071 00 (US $365) Conclusion LAD is an effective tool for damage control in trauma cases
C1 [Kumar, Pramod; Sharma, Ankur] Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Kumar, P (通讯作者)，Kasturba Med Coll & Hosp, Dept Plast Surg, Manipal 576104, Karnataka, India.
RI Kumar, Pramod/L-8280-2015
OI Kumar, Pramod/0000-0001-8831-1804
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NR 15
TC 5
Z9 7
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2010
VL 22
IS 7
BP 188
EP 192
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 629FJ
UT WOS:000280180100005
PM 25901497
DA 2026-07-24
ER

PT J
AU Pushpakumar, SB
   Wilhelmi, BJ
   Van-Aalst, VC
   Banis, JC
   Barker, JH
AF Pushpakumar, Sathnur B.
   Wilhelmi, Brandon J.
   van-Aalst, Vera C.
   Banis, Joseph C., Jr.
   Barker, John H.
TI Abdominal wall reconstruction in a trauma setting
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE abdominal wall trauma; reconstruction; trauma surgeon
ID VACUUM-ASSISTED CLOSURE; TENSOR FASCIAE LATAE; THIGH FLAP; MESH;
   DEFECTS; SEPARATION; WOUNDS; MANAGEMENT; ANATOMY
AB According to the World Health Organization "Global burden of disease study", future demographics of trauma are expected to show an increase in morbidity and mortality. In the past few decades, the field of trauma surgery has evolved to provide global and comprehensive care of the injured. While the modern day trauma surgeon is well trained to deal with multitrauma patients with injuries involving several systems, the ever-increasing nature and variety of multitrauma has left lacuna in certain areas. One such area is the management of abdominal wall injuries, which has been the domain of both plastic and reconstructive and general surgeons. The trauma surgeon is adept at treating the contents of the abdomen but not always the container. If not managed properly complications associated with abdominal wall injuries can lead to increased morbidity and mortality. In considering reconstruction of the abdominal wall in multitrauma patients proper evaluation, scrupulous planning, appropriate, and meticulous technique improve the chances for success with minimal complications. In the present article, we provide a brief description of the most commonly used procedures, and more importantly we outline the principles and guidelines applied to abdominal wall reconstruction in order to inform the trauma surgeon of different available treatment options. in doing so, we hope that this review will assist trauma surgeons in their overall care of patients that present with abdominal injuries.
C1 [Pushpakumar, Sathnur B.; Barker, John H.] Univ Louisville, Plast Surg Res Lab, Louisville, KY 40202 USA.
   [Wilhelmi, Brandon J.] Univ Louisville, Div Plast & Reconstruct Surg, Dept Surg, Louisville, KY 40292 USA.
   [van-Aalst, Vera C.; Banis, Joseph C., Jr.] Banis Plast Surg Associates, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Barker, JH (通讯作者)，Univ Louisville, Plast Surg Res Lab, 511 S Floyd St,320 MDR Bldg, Louisville, KY 40202 USA.
EM jhbark01@louisville.edu
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NR 54
TC 9
Z9 11
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2007
VL 33
IS 1
BP 3
EP 13
DI 10.1007/s00068-007-7023-7
PG 11
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 313HV
UT WOS:000256732600003
PM 26815969
DA 2026-07-24
ER

PT J
AU Galandiuk, S
   Jorden, J
   Mahid, S
   McCafferty, MH
   Tobin, G
AF Galandiuk, S
   Jorden, J
   Mahid, S
   McCafferty, MH
   Tobin, G
TI The use of tissue flaps as an adjunct to pelvic surgery
SO AMERICAN JOURNAL OF SURGERY
LA English
DT Article
DE flaps; radiation injury; verticle rectus abdominus muscle flap; gracilis
   flap
ID ABDOMINIS MUSCULOCUTANEOUS FLAP; VACUUM-ASSISTED CLOSURE;
   RECONSTRUCTION; WOUNDS; ANASTOMOSIS; FISTULAS; OMENTUM
AB Background: The clinical problems of advanced malignancy with invasion of cancers into adjacent organs or structures, fistulizing complications from radiation therapy, postoperative infections, and delayed postoperative healing continue to challenge pelvic surgeons, regardless of subspecialty. The use of autologous muscle and myocutaneous flaps has been applied to the management and prevention of these clinical problems and found to be most helpful.
   Methods: Records of patients undergoing abdominopelvic procedures in a single unit during. the 15-year period from 1990 to 2005 were reviewed, and patients undergoing autologous tissue flaps were reviewed with respect to indications, complications, and outcomes.
   Results: Thirty-four patients underwent 35 autologous muscle or myocutaneous flaps for the following indications: large anticipated defects in primary or reoperative cancer surgery (13 patients); malignant, traumatic, inflammatory, or radiation-induced fistulae (12 patients); excision of (an) adjacent organ(s) with need for reconstruction (7 patients); and chronic nonhealing pelvic wounds (2 patients). Wound complications occurred in 41% of patients; however, primary healing of flaps occurred in 88% of patients.
   Conclusions: The use of autologous tissue flaps in select patients can be a useful adjunct in pelvic surgery in dealing with a wide variety of problems, specifically in filling large defects, providing vascularized tissue for fistula closure, and avoiding delayed wound healing commonly seen after high-dose radiation. (c) 2005 Excerpta Medica Inc. All rights reserved.
C1 Univ Louisville, Sch Med, Dept Surg, Sect Colon & Rectal Surg, Louisville, KY 40292 USA.
   Univ Louisville Hosp, Digest Hlth Ctr, Louisville, KY 40292 USA.
   Univ Louisville, Sch Med, Div Plast & Reconstruct Surg, Louisville, KY 40292 USA.
C3 University of Louisville; University of Louisville; University of
   Louisville
RP Galandiuk, S (通讯作者)，Univ Louisville, Sch Med, Dept Surg, Sect Colon & Rectal Surg, Louisville, KY 40292 USA.
EM s0gala01@gwise.louisville.edu
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NR 16
TC 28
Z9 29
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9610
EI 1879-1883
J9 AM J SURG
JI Am. J. Surg.
PD AUG
PY 2005
VL 190
IS 2
BP 186
EP 190
DI 10.1016/j.amjsurg.2005.05.009
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 947IU
UT WOS:000230637600008
PM 16023428
DA 2026-07-24
ER

PT J
AU Jiang, X
   Xu, Y
   Li, MQ
   Jiao, GQ
   Rong, XS
   Bu, FY
AF Jiang, Xia
   Xu, Yong
   Li, Mingqiu
   Jiao, Guoqing
   Rong, Xiaosong
   Bu, Fanyu
TI Antibiotic-loaded bone cement fixation technique combined with bilateral
   pectoralis major muscle flaps tension-free management for sternal
   infection after midline sternotomy
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Antibiotic-loaded bone cement; Bilateral
   pectoralis major muscle flaps; Tension-free
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; WOUND-INFECTION;
   RISK-FACTORS; VANCOMYCIN; CLASSIFICATION; NEPHROTOXICITY; MEDIASTINITIS;
   PENETRATION; PREVENTION
AB Introduction Deep sternal wound infection (DSWI) after midline sternotomy of cardiac surgery is a challenging complication that affects the outcome of surgery. This study aims to assess the clinical effectiveness of the antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management in the treatment of DSWI.Methods We retrospectively analyzed 5 patients with DSWI who underwent antibiotic-loaded bone cement combined with bilateral pectoralis major muscle flaps for chest wall reconstruction after sternotomy for cardiac surgery in a tertiary hospital in China from January 2020 to December 2021. The clinical and follow-up data were retrospectively analyzed.Results All patients had no perioperative mortalities, no postoperative complications, 100% wound healing, and an average hospital stay length of 24 days. The follow-up periods were from 6 to 35 months (mean 19.6 months). None of the cases showed wound problems after initial reconstruction using antibiotic-loaded bone cement combined with bilateral pectoralis major muscle flaps.Conclusions We report our successful treatment of DSWI, using antibiotic-loaded bone cement fixation technique combined with bilateral pectoralis major muscle flaps tension-free management. The clinical and follow-up results are favorable.
C1 [Jiang, Xia; Xu, Yong; Li, Mingqiu; Jiao, Guoqing; Rong, Xiaosong] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Wuxi Peoples Hosp, Wuxi Med Ctr,Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiang Su Provin, Peoples R China.
   [Bu, Fanyu] Soochow Univ, Dept Chron Wound, Wuxi Peoples Hosp 9, 999 Liangqing Rd, Wuxi 214062, Jiang Su Provin, Peoples R China.
C3 Jiangnan University; Nanjing Medical University; Soochow University -
   China
RP Rong, XS (通讯作者)，Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Wuxi Peoples Hosp, Wuxi Med Ctr,Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiang Su Provin, Peoples R China.; Bu, FY (通讯作者)，Soochow Univ, Dept Chron Wound, Wuxi Peoples Hosp 9, 999 Liangqing Rd, Wuxi 214062, Jiang Su Provin, Peoples R China.
EM rxswx@163.com; bufanyu1020@163.com
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NR 45
TC 4
Z9 4
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD MAY 14
PY 2024
VL 19
IS 1
AR 289
DI 10.1186/s13019-024-02749-0
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA QR3X3
UT WOS:001222569000002
PM 38745239
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Melandri, D
   Marongiu, F
   Carboni, A
   Rubino, C
   Razzano, S
   Purpura, V
   Minghetti, P
   Bondioli, E
AF Melandri, Davide
   Marongiu, Francesco
   Carboni, Andrea
   Rubino, Corrado
   Razzano, Sergio
   Purpura, Valeria
   Minghetti, Paola
   Bondioli, Elena
TI A New Human-Derived Acellular Dermal Matrix for 1-Stage Coverage of
   Exposed Tendons in the Foot
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE human acellular dermal matrix; acellular dermal matrix; wound; exposed
   tendon; one-stage procedure
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; LOWER-EXTREMITY TRAUMA;
   SOFT-TISSUE DEFECTS; ROTATOR CUFF TEARS; ACHILLES-TENDON; RECONSTRUCTIVE
   SURGERY; REGENERATION TEMPLATE; HERNIA REPAIR; AUGMENTATION
AB The closure of wounds associated with soft tissue defects is surgically challenging, frequently requiring extensive plastic surgery and free flaps. The combination of ADM and STSG is an innovative method used to cover such wounds. The human-derived ADMs (H-ADMs) are the most described in the literature but according to European legislations, Companies H-ADMs outside the EC are not allowed to commercialize them in Europe, H-ADMs being "human products" and not "medical devices", so being ruled by European legislations on transplants. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of the first human cadaver-donor derived ADM from the Italian National Transplant Center and National Health Institute, we called with the Italian acronym M.O.D.A. (Matrice Omologa Dermica Acellulata). We present here the first use of a new H-ADM for treatment of distal lower extremity wounds with exposed tendons managed in one-stage pocedure with STSG. The excellent performance suggests that in cases where autologous tissue is unavailable or undesirable, the use of M.O.D.A. in one-stage procedure represents a promising alternative for covering wounds associated with tendons exposition.
C1 [Melandri, Davide; Carboni, Andrea; Purpura, Valeria; Minghetti, Paola; Bondioli, Elena] Osped Gen Provinciale M Bufalini, Cesena, Italy.
   [Marongiu, Francesco] Azienda USL Romagna, Ravenna, Italy.
   [Rubino, Corrado] Univ Sassari, Sassari, Italy.
   [Razzano, Sergio] Osped Niguarda Ca Granda, Milan, Italy.
C3 University of Sassari; Ospedale Niguarda Ca' Granda; IRCCS Ca Granda
   Ospedale Maggiore Policlinico
RP Marongiu, F (通讯作者)，Azienda USL Romagna, Ravenna, Italy.
EM marongiufra@gmail.com
RI PURPURA, VALERIA/K-3052-2018; melandri, davide/AAV-7324-2021
OI PURPURA, VALERIA/0000-0002-1272-313X; melandri,
   davide/0000-0002-3746-308X; Rubino, Corrado/0000-0002-2410-6083
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NR 66
TC 15
Z9 18
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2020
VL 19
IS 1
BP 78
EP 85
AR 1534734619884422
DI 10.1177/1534734619884422
EA NOV 2019
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LA8RW
UT WOS:000495325800001
PM 31679415
DA 2026-07-24
ER

PT J
AU Joseph, SA
   Brandoff, JF
   Menkowitz, M
   O'Shea, J
   Neuwirth, MG
AF Joseph, Samuel A., Jr.
   Brandoff, Jared F.
   Menkowitz, Marc
   O'Shea, Joan
   Neuwirth, Michael G.
TI Lumbar spine fusion: Types, principles, and outcomes
SO NEUROSURGERY QUARTERLY
LA English
DT Review
DE fusion; lumbar spine; principles; complication
ID DONOR SITE PAIN; INSTRUMENTED POSTEROLATERAL FUSION; PEDICLE SCREW
   INSTRUMENTATION; VACUUM-ASSISTED CLOSURE; BONE-GRAFT SUBSTITUTE;
   POSTERIOR ILIAC CREST; BACK SURGERY SYNDROME; INTERBODY FUSION;
   DEGENERATIVE SPONDYLOLISTHESIS; LONG-TERM
AB Lumbar spine fusion rates have increased significantly over the past couple of decades. Spinal fusion procedures are performed for fractures, degenerative conditions, and deformity. The outcomes of these procedures are affected by many factors-both patient and surgeon specific. Therefore, the proper selection of surgical procedures must be carefully individualized on the basis of both clinical and radiographic factors. There have been significant recent advances in the basic science, surgical technique, and instrumentation used to obtain a successful lumbar spinal fusion. These advances continue to be based on the same basic tenants of preparing a proper biologic fusion bed and minimizing motion at the fusion site. New growth factors to enhance the biology and more rigid instrumentation to prevent motion at the fusion site are goals that the surgeon along with the industry has continued to pursue. The recent introduction of minimally invasive surgery also drives the surgeon to attempt both to reduce postoperative pain, blood loss, and length of hospital stay. The results of these recent technologies, however, remain to be answered. This is a review of lumbar spinal fusion, focusing on the basic principles necessary for a successful outcome, the multitude of approaches and types available to the spinal surgeon, possible complications and also recent advances and emerging technology that may provide better fusion rates and hopefully patient satisfaction.
C1 [Joseph, Samuel A., Jr.; Brandoff, Jared F.; Menkowitz, Marc; Neuwirth, Michael G.] Beth Israel Deaconess Med Ctr, Spine Inst New York, New York, NY 10003 USA.
   [O'Shea, Joan] Spine Inst S Jersey, Marlton, NJ USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Joseph, SA (通讯作者)，Beth Israel Deaconess Med Ctr, Spine Inst New York, 10 Union Sq E,Suite 5P, New York, NY 10003 USA.
EM sjmdbones@yahoo.com
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NR 142
TC 1
Z9 4
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1050-6438
EI 1534-4916
J9 NEUROSURG QUART
JI Neurosurg. Q.
PD MAR
PY 2008
VL 18
IS 1
BP 34
EP 44
DI 10.1097/WNQ.0b013e31816427a4
PG 11
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 273MW
UT WOS:000253936000007
DA 2026-07-24
ER

PT J
AU Yoon, TH
   Lee, HS
   Lee, CH
   Jeon, YH
AF Yoon, Tae-Hong
   Lee, Han Sol
   Lee, Chul Ho
   Jeon, Yun-Ho
TI Successful treatment of gastropulmonary fistula in a patient with
   gastric diverticulum: A case report
SO MEDICINE
LA English
DT Article
DE gastric diverticulum; gastropulmonary fistula
ID GASTROBRONCHIAL FISTULA; MANAGEMENT
AB Rationale:Gastropulmonary fistula (GPF) is defined as a communication pathway between the stomach and the lung. GPF is a rare condition, and there is no consensus regarding its treatment. GPF has been reported in only a small number of cases.Patient concerns:A 61-year-old male patient visited the emergency room due to abdominal pain and concurrent hematemesis that started 2 days prior. The patient reported a history of frequent vomiting attributed to chronic alcoholism and gastric ulcer-related bleeding. Multiple gastric ulceration and gastric diverticulum were diagnosed at that time.Diagnoses:GPF was diagnosed by a noncontrast-enhanced chest computed tomography scan after swallowing an oral contrast agent.Interventions:GPF was treated with surgical intervention. A left lower lobectomy was performed through a posterolateral thoracotomy at the left 6th intercostal space. The 2.5 cm diaphragmatic opening was closed using a pledgeted 2-0 Prolene suture. In the abdomen, a partial gastrectomy was performed via an upper median laparotomy.Outcomes:Successful surgical management of a PGF. Postoperative pneumonia developed on postoperative day (POD) 3, prompting a change in antibiotics. On POD20, an abdominal wound infection occurred, for which a vacuum-assisted closure system was applied. The patient began oral intake on POD33 and was discharged on POD56 after the removal of the tracheostomy tube.Lessons:This case demonstrates that surgical intervention should be considered the primary treatment option when managing a patient diagnosed with GPF.
C1 [Yoon, Tae-Hong; Lee, Han Sol; Lee, Chul Ho; Jeon, Yun-Ho] Daegu Catholic Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 33 Duryugongwon Ro 17 Gil, Daegu, South Korea.
C3 Catholic University of Daegu
RP Jeon, YH (通讯作者)，Daegu Catholic Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 33 Duryugongwon Ro 17 Gil, Daegu, South Korea.
EM drdrumhong@naver.com; poohrooh@naver.com; poohrooh@naver.com;
   yunja0129@naver.com
OI chul ho, Lee/0000-0002-9139-0619; Jeon, Yun-Ho/0000-0002-5283-3261; LEE,
   HANSOL/0000-0003-1916-2926; Yoon, Tae-hong/0000-0002-4609-3498
CR Ben Nun A, 2018, WORLD J SURG, V42, P1792, DOI 10.1007/s00268-017-4358-z
   Guillaud A, 2015, OBES SURG, V25, P2352, DOI 10.1007/s11695-015-1702-y
   Janilionis Ricardas, 2016, Acta Med Litu, V23, P169, DOI [10.6001/actamedica.v23i3.3381, 10.6001/actamedica.v23i3.3381]
   Lee Seong Kwang, 2010, The Korean Journal of Thoracic and Cardiovascular Surgery, V43, P340
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   Mehran Amir, 2005, JSLS, V9, P213
   Rebibo L, 2014, SURG OBES RELAT DIS, V10, P460, DOI 10.1016/j.soard.2013.08.015
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   van de Vrande S, 2013, SURG OBES RELAT DIS, V9, P856, DOI 10.1016/j.soard.2013.01.003
NR 9
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR 18
PY 2025
VL 104
IS 16
AR e42152
DI 10.1097/MD.0000000000042152
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2GH5K
UT WOS:001481964200007
PM 40258765
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kashyap, S
   Podkovik, S
   Tashjian, V
AF Kashyap, Samir
   Podkovik, Stacey
   Tashjian, Vartan
TI Disseminated intravascular coagulation in spine surgery: illustrative
   case review and the paradigms of management
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Review
DE disseminated intravascular coagulation; factor VIIa; bleeding disorders;
   meningioma; wound VAC; vascular disorders
ID TRAUMA
AB Disseminated intravascular coagulation (DIC) is rarely encountered by spine surgeons outside of deformity or severe trauma cases. The authors report an extraordinarily unique case of refractory DIC after elective resection of multiple en plaque thoracic meningiomas in a patient with neurofibromatosis type 1. A 49-year-old man underwent T1-3 laminoplasty and expansile duraplasty for resection of multiple en plaque meningiomas for thoracic myelopathy. Intraoperatively, the patient was found to be in a state of DIC that did not resolve postoperatively despite massive transfusions of blood products. He required subsequent returns to the operating room due to recurrent epidural hematomas with resulting paraplegia. Ultimately, the wound was left open, and a wound vacuum-assisted closure (VAC) was placed to prevent further returns to the operating room. DIC persisted until the administration of recombinant factor VIIa. In this report, the authors review the mechanisms, subtypes, and approaches to treatment of DIC with a focus on the bleeding subtype. If this subtype is refractory to blood product administration (> 24 hours), recombinant factor VIIa is a safe and effective option. A wound VAC can be safely utilized with exposed dura if deemed necessary by the surgeon; however, the volume and characteristics of the output should be closely monitored. The use of unconventional surgical solutions may provide options to mitigate the morbidity associated with refractory DIC in spine surgery.
C1 [Kashyap, Samir; Podkovik, Stacey] Riverside Univ Hlth Syst, Dept Neurosurg, Riverside, CA USA.
   [Kashyap, Samir; Podkovik, Stacey; Tashjian, Vartan] Kaiser Permanente Fontana Med Ctr, Dept Neurosurg, Fontana, CA USA.
C3 Kaiser Permanente
RP Kashyap, S (通讯作者)，Riverside Univ Hlth Syst, Riverside, CA 92503 USA.
EM skashyap41@gmail.com
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NR 24
TC 0
Z9 0
U1 0
U2 1
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD JAN
PY 2020
VL 32
IS 1
BP 139
EP 143
DI 10.3171/2019.7.SPINE19756
PG 5
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA JZ3TG
UT WOS:000505023600019
PM 31604327
DA 2026-07-24
ER

PT J
AU Sinna, R
   Qassemyar, Q
   Boloorchi, A
   Benhaim, T
   Carton, S
   Perignon, D
   Robbe, M
AF Sinna, R.
   Qassemyar, Q.
   Boloorchi, A.
   Benhaim, T.
   Carton, S.
   Perignon, D.
   Robbe, M.
TI Role of the association artificial dermis and negative pressure therapy:
   About two cases
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Artificial dermis; Negative pressure therapy; Medicoeconomic benefits
ID SKIN SUBSTITUTES; MANAGEMENT; TEMPLATE; INTEGRA; TISSUE; BURNS
AB In our modern health system, the improvement of the medical care cannot come along with an increase of expenses. In this purpose, we tried to bring to light the medical and economic, direct and indirect, benefits which exist with the association of an artificial dermis, Integra(R), and negative pressure therapy as the vacuum assisted closure (VAC(R)) for wound which would have been treated by Integra(R) alone. While preserving the aesthetic and functional qualities obtained by the artificial dermis alone followed by a skin graft after 21 days of treatment, the association of the negative pressure allows to perform the skin graft after only 10 days of treatment. This gain of time is a financial economy for the medical centers which have to shorten the durations of stay to be profitable. The patient benefits of a shorter hospitalization and will manage to return to work earlier. The quality of the treatment is not only improved by the absentia of immobilization of the patient but also by the decrease of the complications and the infectious risks due to the use of artificial dermis. The results so obtained highlight that in spite of the initial expense caused by this association the advantages are such that the use of the artificial dermis alone will not have interest any more. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Sinna, R.; Qassemyar, Q.; Boloorchi, A.; Benhaim, T.; Carton, S.; Perignon, D.; Robbe, M.] CHU Nord Amiens, Hop Nord, Serv Chirurg Plast Reconstructrice & Esthet, F-80054 Amiens 1, France.
C3 Universite de Picardie Jules Verne (UPJV); CHU Amiens
RP Sinna, R (通讯作者)，CHU Nord Amiens, Hop Nord, Serv Chirurg Plast Reconstructrice & Esthet, Pl Victor Pauchet, F-80054 Amiens 1, France.
EM raphaelsinna@gmail.com
RI Qassemyar, Quentin/AAF-5105-2019
CR [Anonymous], ANN PLAST SURG
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NR 15
TC 10
Z9 10
U1 0
U2 4
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD DEC
PY 2009
VL 54
IS 6
BP 582
EP 587
DI 10.1016/j.anplas.2009.02.003
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 538CE
UT WOS:000273160900011
PM 19345466
DA 2026-07-24
ER

PT J
AU Clavert, P
   Puliero, B
   Eichler, D
   Ollivier, I
   Bonnomet, F
AF Clavert, Philippe
   Puliero, Benjamin
   Eichler, David
   Ollivier, Irene
   Bonnomet, Francois
TI The distal fibular perforating axial flap for lateral malleolus
   coverage: an anatomical description and surgical technique
SO SURGICAL AND RADIOLOGIC ANATOMY
LA English
DT Article
DE Fasciocutaneous flap; Ankle; Lateral malleolus; Perforating arteries
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE COVERAGE; ANKLE; FOOT
AB PurposeSkin closure disorders in ankle surgery are a recurrent problem not only in traumatology but also in elective surgery. The aim of the study was to describe the anatomical basis of the fasciocutaneous vascularization of the lateral malleolus region to develop a posterior cover flap for the region.MethodsWe dissected ten fresh frozen specimens after arterial injection of an Indian ink preparation and individualized the perforating arteries. Their positions and diameters were collated. Then, the surgical technique was clinically applied for two different cases by transferring the fasciocutaneous flap posterior to the lateral malleolus to cover a loss of skin substance.ResultsThere were in average 5 fibular perforators over the last 100 mm of the fibula. The average diameter of the first two perforating arteries was 0.6 & PLUSMN; 0.12 mm and 0.9 & PLUSMN; 0.25 mm, respectively, and the consistency of the latter makes it possible to produce a skin flap with anterior translation. This is an axial flap. Two patients were operated on using this technique. There was no necrosis of the posterior fibular flap and healing was achieved by the third post-operative week.ConclusionThis study showed the presence of fibular perforating arteries with a high reproducibility of their dissection. This anatomical description served as the basis for the description of a new distal fibular perforating flap.
C1 [Clavert, Philippe; Puliero, Benjamin; Ollivier, Irene] Inst Normal Anat, Med Sch, 4 rue Kirschleger, F-67085 Strasbourg, France.
   [Clavert, Philippe; Puliero, Benjamin; Eichler, David; Bonnomet, Francois] Univ Hosp Hautepierre, Dept Orthoped, Strasbourg, France.
C3 CHU Strasbourg
RP Clavert, P (通讯作者)，Inst Normal Anat, Med Sch, 4 rue Kirschleger, F-67085 Strasbourg, France.; Clavert, P (通讯作者)，Univ Hosp Hautepierre, Dept Orthoped, Strasbourg, France.
EM philippe.clavert@chru-strasbourg.fr
OI CLAVERT, Philippe/0000-0002-6977-2864
CR Angelis S, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.5104
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   Bhattacharyya T, 2008, PLAST RECONSTR SURG, V121, P1263, DOI 10.1097/01.prs.0000305536.09242.a6
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 0930-1038
EI 1279-8517
J9 SURG RADIOL ANAT
JI Surg. Radiol. Anat.
PD OCT
PY 2023
VL 45
IS 10
BP 1191
EP 1196
DI 10.1007/s00276-023-03204-w
EA AUG 2023
PG 6
WC Anatomy & Morphology; Radiology, Nuclear Medicine & Medical Imaging;
   Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Radiology, Nuclear Medicine & Medical Imaging;
   Surgery
GA S9YR7
UT WOS:001043659600001
PM 37550484
DA 2026-07-24
ER

PT J
AU Mohammed, AH
   Hamed, SA
   Abdelghany, AI
AF Mohammed, Ashraf H.
   Hamed, Somia Ali
   Abdelghany, Abdelrhman Ismail
TI Comparison between two different protocols of negative pressure therapy
   for healing of chronic ulcers
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Wound healing; Negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; SUCTION DRAINAGE; INSTILLATION;
   MANAGEMENT; TRIAL; FOAM
AB Background: Negative pressure therapy plays an important role in the healing process of different types of wounds. Aim of the study: this study aimed to compare between modified and traditional method of vacuum wound closure for chronic wounds.
   Subjects: Thirty participants with chronic ulcers completed the study, their ages ranged from 47 to 65 years, from Benha city, divided randomly into two groups, it was carried out from December 2017 to March 2019.
   Methods: The first group treated by the traditional method of vacuum assisted wound closure for 8 weeks; dressing was changed 3 times weekly, at 125 mmHg. The mode of 2 min off and 5 min on was used. The second group treated by the modified method by switching off the device at the fifth week and applying traditional dressing for one week then ended by three weeks of vacuum wound closure. Assessment was performed before and after the study. Student t-test was used for analysis.
   Result: Paired t-test showed a significant improvement in wound surface area as well as volume for pre and post treatment in each group (p < 0.05). On the other hand independent t-test revealed a non-significant difference between the two groups pre as well as post treatment (p > 0.05).
   Conclusion: There is no significant difference between the two programs on healing of chronic ulcers.
C1 [Mohammed, Ashraf H.] Cairo Univ, Cairo, Egypt.
   [Hamed, Somia Ali] October 6 Univ, Cairo, Egypt.
   [Mohammed, Ashraf H.; Abdelghany, Abdelrhman Ismail] Badr Univ, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); October 6 University (O6U); Badr University in Cairo
RP Mohammed, AH (通讯作者)，Badr Univ Cairo, Cairo Univ, Cairo, Egypt.
EM ashraf.hassan@buc.edu.eg
RI ; Hamed, Somaia/ABD-4373-2020
OI mohammed, ashraf/0000-0003-4223-1483; Hamed, Somaia/0000-0001-9794-7353
CR [Anonymous], E PLASTY
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NR 26
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD FEB
PY 2020
VL 29
IS 1
BP 37
EP 41
DI 10.1016/j.jtv.2019.10.003
PG 5
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA KV6RS
UT WOS:000520610200008
PM 31677995
DA 2026-07-24
ER

PT J
AU Bouza, E
   de Alarcon, A
   Farinas, MC
   Galvez, J
   Goenaga, MA
   Gutierrez-Diez, F
   Hortal, J
   Lasso, J
   Mestres, CA
   Miro, JM
   Navas, E
   Nieto, M
   Parra, A
   de la Sota, EP
   Rodriguez-Abella, H
   Rodriguez-Creixems, M
   Rodriguez-Roda, J
   Espin, GS
   Sousa, D
   de Sierra, CVG
   Munoz, P
   Kestler, M
AF Bouza, Emilio
   de Alarcon, Aristides
   Farinas, Maria Carmen
   Galvez, Juan
   Goenaga, Miguel Angel
   Gutierrez-Diez, Francisco
   Hortal, Javier
   Lasso, Jose
   Mestres, Carlos A.
   Miro, Jose M.
   Navas, Enrique
   Nieto, Mercedes
   Parra, Antonio
   Perez de la Sota, Enrique
   Rodriguez-Abella, Hugo
   Rodriguez-Creixems, Marta
   Rodriguez-Roda, Jorge
   Sanchez Espin, Gemma
   Sousa, Dolores
   Velasco Garcia de Sierra, Carlos
   Munoz, Patricia
   Kestler, Martha
TI Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in
   Adults Consensus Guidelines of the Spanish Society of Cardiovascular
   Infections (SEICAV), the Spanish Society of Thoracic and
   Cardiovascular Surgery (SECTCV) and the Biomedical Research
   Centre Network for Respiratory Diseases (CIBERES)
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE mediastinitis; sternal wound infections; post-surgical mediastinitis;
   cardiac surgery; infection; surgical wound infection
ID STERNAL WOUND-INFECTION; VACUUM-ASSISTED CLOSURE; SURGICAL-SITE
   INFECTIONS; RESISTANT STAPHYLOCOCCUS-AUREUS; POST-STERNOTOMY
   MEDIASTINITIS; NEGATIVE-PRESSURE THERAPY; BYPASS GRAFT-SURGERY;
   HIGH-RISK PATIENTS; CLINICAL-PRACTICE GUIDELINE; GENTAMICIN-COLLAGEN
   SPONGE
AB This is a consensus document of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES). These three entities have brought together a multidisciplinary group of experts that includes anaesthesiologists, cardiac and cardiothoracic surgeons, clinical microbiologists, infectious diseases and intensive care specialists, internal medicine doctors and radiologists. Despite the clinical and economic consequences of sternal wound infections, to date, there are no specific guidelines for the prevention, diagnosis and management of mediastinitis based on a multidisciplinary consensus. The purpose of the present document is to provide evidence-based guidance on the most effective diagnosis and management of patients who have experienced or are at risk of developing a post-surgical mediastinitis infection in order to optimise patient outcomes and the process of care. The intended users of the document are health care providers who help patients make decisions regarding their treatment, aiming to optimise the benefits and minimise any harm as well as the workload.
C1 [Bouza, Emilio; Rodriguez-Creixems, Marta; Munoz, Patricia; Kestler, Martha] Univ Complutense Madrid, Gregorio Maranon Univ Hosp, Gregorio Maranon Hlth Res Inst, Clin Microbiol & Infect Dis Dept,CIBER Resp Dis,C, Madrid 28007, Spain.
   [de Alarcon, Aristides] Virgen Rocio Univ Hosp, Seville 41013, Spain.
   [Farinas, Maria Carmen] Marques Valdecilla Univ Hosp, Santander 39008, Spain.
   [Galvez, Juan] Virgen Macarena Univ Hosp, Seville 41009, Spain.
   [Goenaga, Miguel Angel] Donosti Hosp, Donostia San Sebastian 20014, Spain.
   [Gutierrez-Diez, Francisco] Marques Valdecilla Univ Hosp, Cardiovasc Surg Dept, Santander 39008, Spain.
   [Hortal, Javier] Gregorio Maranon Univ Hosp, Anesthesia & Intens Care Dept, Madrid 28007, Spain.
   [Lasso, Jose] Gregorio Maranon Univ Hosp, Plast Surg Dept, Madrid 28007, Spain.
   [Mestres, Carlos A.] Univ Zurich Hosp, Dept Cardiac Surg, CH-8091 Zurich, Switzerland.
   [Miro, Jose M.] Univ Barcelona, Hosp Clin IDIBAPS, Infect Dis Serv, Barcelona 08036, Spain.
   [Navas, Enrique] Ramon Cajal Univ Hosp, Infect Dis Dept, Madrid 28034, Spain.
   [Nieto, Mercedes] San Carlos Clin Hosp, Dept Intens Care, Cardiovasc Unit, Madrid 28040, Spain.
   [Parra, Antonio] Marquez Valdecilla Univ Hosp, Dept Radiol, Santander 39008, Spain.
   [Perez de la Sota, Enrique] Hosp 12 Octubre, Cardiac Surg Dept, Madrid 28041, Spain.
   [Rodriguez-Abella, Hugo] Gregorio Maranon Univ Hosp, Cardiac Surg Dept, Madrid 28007, Spain.
   [Rodriguez-Roda, Jorge] Ramon Cajal Hosp, Cardiac Surg Dept, Madrid 28034, Spain.
   [Sanchez Espin, Gemma] Virgen Victoria Univ Hosp, Heart Clin Management Unit, Malaga 29006, Spain.
   [Sousa, Dolores] A Coruna Hosp Complex, Infect Dis Dept, La Coruna 15006, Spain.
   [Velasco Garcia de Sierra, Carlos] A Coruna Hosp Complex, Cardiac Surg Dept, La Coruna 15006, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERES; General
   University Gregorio Maranon Hospital; Complutense University of Madrid;
   Virgen del Rocio University Hospital; Hospital Universitario Marques de
   Valdecilla (HUMV); Hospital Universitario Virgen Macarena; Hospital
   Universitario Marques de Valdecilla (HUMV); General University Gregorio
   Maranon Hospital; General University Gregorio Maranon Hospital;
   University of Zurich; University Zurich Hospital; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital Universitario
   Ramon y Cajal; Hospital Universitario 12 de Octubre; General University
   Gregorio Maranon Hospital; Hospital Universitario Ramon y Cajal
RP Kestler, M (通讯作者)，Univ Complutense Madrid, Gregorio Maranon Univ Hosp, Gregorio Maranon Hlth Res Inst, Clin Microbiol & Infect Dis Dept,CIBER Resp Dis,C, Madrid 28007, Spain.
EM emilio.bouza@salud.madrid.org; caristo.alarcon.sspa@juntadeandalucia.es;
   mcfarinas@humv.es; jga@us.es; miguelangel.goenagasanchez@osakidetza.eus;
   josefrancisco.gutierrez@scsalud.es;
   franciscojavier.hortal@salud.madrid.org;
   josemaria.lasso@salud.madrid.org; carlos.mestres@usz.ch;
   josemaria@miromoreno.org; enavase@salud.madrid.org;
   mernietoc@salud.madrid.org; joseantonio.parra@scsalud.es;
   epsccv@arrakis.es; rhugorodriguez@salud.madrid.org;
   jorge.rodriguez-roda@salud.madrid.org;
   gemma.sanchez.sspa@juntadeandalucia.es; dsoureg@sergas.es;
   carlos.velasco.garcia.de.sierra@sergas.es;
   martha.kestler@salud.madrid.org
RI Munoz, Patricia/E-9431-2017; Sousa, Dolores/JNT-4351-2023; PEREZ DE LA
   SOTA, ENRIQUE/AAX-5488-2020; Bouza, Emilio/D-8661-2014; Miro,
   Jose/AAY-7958-2020; Sánchez-Espín, Gemma/E-7688-2018
OI Munoz, Patricia/0000-0001-5706-5583; PEREZ DE LA SOTA,
   ENRIQUE/0000-0002-3816-9739; Mestres, Carlos - A/0000-0001-8148-9044;
   Nieto-Cabrera, Mercedes/0000-0001-6555-5638; Kestler,
   Martha/0000-0003-3307-1545; 
FU IDIBAPS
FX J.M. Miro was a recipient of a personal 80:20 research grant from
   IDIBAPS during the period 2017-2021.
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NR 309
TC 22
Z9 31
U1 0
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2021
VL 10
IS 23
AR 5566
DI 10.3390/jcm10235566
PG 41
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XW2KK
UT WOS:000735454600001
PM 34884268
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pleger, SP
   Nink, N
   Elzien, M
   Kunold, A
   Koshty, A
   Böning, A
AF Pleger, Sebastian P.
   Nink, Nadine
   Elzien, Meshal
   Kunold, Alexander
   Koshty, Ahmed
   Boening, Andreas
TI Reduction of groin wound complications in vascular surgery patients
   using closed incision negative pressure therapy (ciNPT): a prospective,
   randomised, single-institution study
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE closed incision negative pressure therapy; surgical site infections;
   vascular surgery; wound healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISION; HIGH-RISK; ARTERIAL
   RECONSTRUCTION; MANAGEMENT-SYSTEM; SKIN-GRAFTS; INFECTION; PREVENTION;
   PREVENA(TM); DRESSINGS
AB Groin wound infections in patients undergoing vascular procedures often cause a lengthy process of wound healing. Several clinical studies and case reports show a reduction of surgical site infections (SSIs) in various wound types after using closed incision negative pressure therapy (ciNPT). The aim of this prospective, randomised, single-institution study was to investigate the effectiveness of ciNPT (PREVENA Therapy) compared to conventional therapy on groin incisions after vascular surgery. From 1 February to 30 October 2015, 100 patients with 129 groin incisions were analysed. Patients were randomised and treated with either ciNPT (n = 58 groins) or the control dressing (n = 71 groins). ciNPT was applied intraoperatively and removed on days 5-7 postoperatively. The control group received a conventional adhesive plaster. Wound evaluation based on the Szilagyi classification took place postoperatively on days 5-7 and 30. Compared to the control group, the ciNPT group showed a significant reduction in wound complications (P < 00005) after both wound evaluation periods and in revision surgeries (P = 0022) until 30 days postoperatively. Subgroup analysis revealed that ciNPT had a significant effect on almost all examined risk factors for wound healing. ciNPT significantly reduced the incidence of incision complications and revision procedures after vascular surgery.
C1 [Pleger, Sebastian P.; Nink, Nadine; Elzien, Meshal; Kunold, Alexander; Koshty, Ahmed] Jung Stilling Hosp, Dept Vasc Surg, Wichernstr 40, D-57074 Siegen, Germany.
   [Pleger, Sebastian P.; Boening, Andreas] Justus Liebig Univ, Univ Hosp, Dept Cardiovasc Surg, Giessen, Germany.
C3 Justus Liebig University Giessen
RP Pleger, SP (通讯作者)，Jung Stilling Hosp, Dept Vasc Surg, Wichernstr 40, D-57074 Siegen, Germany.
EM sebastian.pleger@diakonie-sw.de
RI Boening, Andreas/LMN-9531-2024
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NR 42
TC 84
Z9 90
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2018
VL 15
IS 1
BP 75
EP 83
DI 10.1111/iwj.12836
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FU4JG
UT WOS:000423818800011
PM 29068153
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Marjanovic, VG
   Budic, IZ
   Zecevic, MD
   Stevic, MM
   Simic, DM
AF Marjanovic, Vesna G.
   Budic, Ivana Z.
   Zecevic, Maja D.
   Stevic, Marija M.
   Simic, Dusica M.
TI Intra-abdominal hypertension/abdominal compartment syndrome of pediatric
   patients in critical care settings
SO OPEN MEDICINE
LA English
DT Review
DE intra-abdominal hypertension; abdominal compartment syndrome; children
ID NEAR-INFRARED SPECTROSCOPY; VACUUM-ASSISTED CLOSURE; ILL CHILDREN; OPEN
   ABDOMEN; INTERNATIONAL-CONFERENCE; PRESSURE; MANAGEMENT; SECONDARY;
   LAPAROTOMY; OUTCOMES
AB Background Intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) is one of the rarer clinical entities in the pediatric population, carrying a high degree of morbidity and mortality. The focus of this review is on assessing pathophysiological changes of organ systems in pediatric patients with risk factors for the occurrence of IAH/ACS based on the evaluation of diagnostic modalities and therapeutic strategies.Methodology A comprehensive literature search of indexed databases was performed, aiming to identify, review, and evaluate published articles on IAH/ACS. The search was focused on studies examining pathophysiology, risk factors, diagnostic approaches, and management strategies.Results The main risk factors encompass diminished abdominal wall compliance, increased intraluminal and abdominal contents, and capillary leak/fluid resuscitation. Diagnostic tools include clinical and imaging findings, intra-abdominal pressure (IAP) monitoring, and parameters of tissue perfusion. Therapeutic strategies involve non-surgical and surgical management of IAH/ACS in pediatric patients.Conclusion Timely and continuous evaluation of IAP and parameters of tissue perfusion is crucial for the early diagnosis of IAH/ACS and implementing non-surgical procedures, reducing the need for surgical procedures. Future research should focus on the usefulness of advanced non-invasive monitoring technologies and the identification of predictors of increased IAP in the early implementation of personalized therapeutic strategies.
C1 [Marjanovic, Vesna G.; Budic, Ivana Z.] Univ Nis, Univ Clin Ctr Nis, Med Fac, Clin Anesthesiol & Intens Therapy, Nish, Serbia.
   [Zecevic, Maja D.] Univ Nis, Univ Clin Ctr Nis, Med Fac, Clin Pediat Surg Pediat Orthoped & Traumatol, Nish, Serbia.
   [Stevic, Marija M.; Simic, Dusica M.] Univ Belgrade, Univ Childrens Hosp, Dept Anesthesiol & Intens Therapy, Med Fac, Belgrade, Serbia.
C3 University of Nis; University of Nis; University of Belgrade
RP Marjanovic, VG (通讯作者)，Univ Nis, Univ Clin Ctr Nis, Med Fac, Clin Anesthesiol & Intens Therapy, Nish, Serbia.
EM drvesnamarjanovic@gmail.com
FU Medical Faculty, University of Nis, Serbia [42/2020]
FX This work has been supported by an internal grant initiated in 2020 (No.
   42/2020) at the Medical Faculty, University of Nis, Serbia.
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NR 69
TC 0
Z9 1
U1 0
U2 4
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD JUL 17
PY 2025
VL 20
IS 1
AR 20251244
DI 10.1515/med-2025-1244
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4ZH1L
UT WOS:001530228400001
PM 40688036
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Frerichs, O
   Brüner, S
   Fansa, H
AF Frerichs, O
   Brüner, S
   Fansa, H
TI Value of VAC®-therapy in the treatment of sternal infections
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE sternal infection; VAC (R)-therapy; flap surgery
ID CHEST-WALL; FLAP; DEFECTS; REPAIR
AB Osteomyelitis of the sternum is a dreaded complication after sternotomy and is related to high mortality. Control of infection by radical debridement is the key to successful treatment. Instability of the thoracic cage can lead to a high complication rate. 16 Patients with an infected and unstable sternum underwent radical debridement with resection of the sternum and adjacent ribs. 6 Patients (group A) received an immediate defect coverage with a pedicled muscle flap. 10 Patients (group 13) were treated with a vacuum-assisted closure (V.A.C.(R))-therapy until stabilization of their general condition and underwent defect coverage in a second operation. Healing of the flaps was uneventful in all cases despite minor problems. 5 patients of group A had severe complications with pulmonal or cardiac failure and thoracic instability which lead to prolonged periods of mechanical ventilation. 2 patients of this group died due to multi organ failure. All patients of group B survived and there were no major complications. All of the patients were free of recurrence from their osteomyelitis during follow-up. V.A.C.(R)-therapy after radical resection of sternum osteomyelitis proved to be an effective measure to bridge time while optimizing the status of the patient and it's wound. With this approach we believe to have lowered the rate of major complications in this multimorbid patient group by reducing the burden of one large operation and by improving thoracic stability.
C1 Klinikum Bielefeld, Klin Plast Wiederherstellungs & Asthet Chirurg, D-33604 Bielefeld, Germany.
RP Frerichs, O (通讯作者)，Klinikum Bielefeld, Klin Plast Wiederherstellungs & Asthet Chirurg, Teutoburger Str 50, D-33604 Bielefeld, Germany.
EM onno.frerichs@sk-bielefeld.de
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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NR 9
TC 1
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S120
EP S123
DI 10.1055/s-2006-921459
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100028
PM 16575661
DA 2026-07-24
ER

PT J
AU Shi, YD
   Qi, FZ
   Zhang, Y
AF Shi, Yue-Dong
   Qi, Fa-Zhi
   Zhang, Yong
TI Treatment of sternal wound infections after open-heart surgery
SO ASIAN JOURNAL OF SURGERY
LA English
DT Article
DE infection; muscle flap; sterpotomy
ID TRANSVERSE PLATE FIXATION; RECONSTRUCTION; COMPLICATIONS; MANAGEMENT;
   RISK; FLAP
AB Objective: The aim of this study was to investigate the proper treatment of infected median sternotomy wounds.
   Methods: A retrospective study was conducted to investigate the proper treatment of infected median sternotomy wounds on patients with sternal wound infections from January 2007 to July 2009. The characteristics of the sternal infections and the treatment outcomes were analysed.
   Results: Ninety-seven patients with sternal wound infections were treated. A total of 32 patients acquired the infection within one month after open-heart surgery, 10 patients got the infection one to two months after the surgery, and 1 patient died two days after debridement. There were 54 patients who acquired the infection beyond two months post-surgery, while 1 patient died on the day before the operation. One patient received four cycles of wound debridement, 18 patients received two cycles and 78 patients only received one cycle. A total of 14 patients received a vacuum-assisted closure treatment. There were 73 patients who had surgery for repair of muscle flaps, 1 patient for breast tissue flap, 63 patients for pectoralis major muscle flap, and 9 patients with rectus abdominis muscle flap. There were 12 patients who received a transverse plate fixation of the sternum with titanium plating.
   Conclusion: A positive prognosis can be obtained by the algorithm treatment based on the onset and depth of the sternal infection. Copyright (c) 2013, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Shi, Yue-Dong; Qi, Fa-Zhi; Zhang, Yong] Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Qi, FZ (通讯作者)，Fudan Univ, Zhongshan Hosp, Dept Plast & Reconstruct Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM dsyzcn@163.com
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   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
NR 19
TC 15
Z9 19
U1 1
U2 3
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD JAN
PY 2014
VL 37
IS 1
BP 24
EP 29
DI 10.1016/j.asjsur.2013.07.006
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AC2SH
UT WOS:000332353800005
PM 23972506
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Mullins, RF
   Hassan, Z
   Homsombath, B
   Fagan, S
   Craft-Coffman, B
   Wilson, J
   Rumbaugh, JG
   Saunders, M
   Danilkovitch, A
AF Mullins, Robert F.
   Hassan, Zaheed
   Homsombath, Bounthavy
   Fagan, Shawn
   Craft-Coffman, Beretta
   Wilson, Joan
   Rumbaugh, John G.
   Saunders, Molly
   Danilkovitch, Alla
TI Prospective, Single-center, Open-label, Pilot Study Using Cryopreserved
   Umbilical Tissue Containing Viable Cells in the Treatment of Complex
   Acute and Chronic Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE viable; cryopreserved; umbilical tissue; complex; wound
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; THERAPY; MANAGEMENT;
   MEMBRANE
AB Introduction. Complex wounds with exposed bone, muscle, tendon, or hardware continue to be a therapeutic challenge for wound care providers. Wounds with exposed structures are more susceptible to infection, necrosis, and amputation. As such, rapid granulation to cover exposed deep tissue structures is essential for patient recovery. Objective. In this prospective, pilot study, the authors evaluate the clinical outcomes of a cryopreserved umbilical tissue graft containing viable cells (vCUT) in the treatment of complex wounds. Materials and Methods. Ten patients with 12 wounds each received 1 application of vCUT. Two patients did not complete the study and were removed from the per-protocol population. Data analyses were performed on the remaining 8 patients with 10 wounds. The average wound area was 16.5 cm(2) with an average duration of 10 months. Post-application, patients were followed for an additional 4 weeks for granulation, closure, and safety outcomes. Results. By the end of the study, 8 of 10 (80.0%) vCUT-treated wounds achieved 100% granulation, and 3 wounds (30.0%) went on to achieve complete closure. The median area reduction was 40.5% and the median volume reduction was 59.4%. Conclusions. The results of this study suggest vCUT in conjunction with standard of care can be a viable treatment option for acute and chronic lower extremity complex wounds.
C1 [Mullins, Robert F.; Hassan, Zaheed; Homsombath, Bounthavy; Fagan, Shawn; Craft-Coffman, Beretta] Joseph M Still Res Fdn, JMS Burn Ctr, Augusta, GA USA.
   [Wilson, Joan; Rumbaugh, John G.] Joseph M Still Res Fdn, Augusta, GA USA.
   [Saunders, Molly; Danilkovitch, Alla] Osiris Therapeut Inc, Columbia, MD 21046 USA.
C3 Osiris Therapeutics
RP Saunders, M (通讯作者)，Osiris Therapeut Inc, Clin Operat, Clin, 7015 Albert Einstein Dr, Columbia, MD 21046 USA.
EM molly.saunders@smith-nephew.com
RI Mullins, Robert/I-6717-2013
FU Osiris Therapeutics
FX Ms. Saunders is a current employee of Osiris Therapeutics. Dr.
   Danilkovitch was a former employee of Osiris Therapeutics. This study
   was funded by Osiris Therapeutics.
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NR 30
TC 0
Z9 0
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2020
VL 32
IS 8
BP 221
EP 227
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QA6LH
UT WOS:000613554600004
PM 32813668
DA 2026-07-24
ER

PT J
AU Zagory, JA
   Golden, J
   Holoyda, K
   Demeter, N
   Nguyen, NX
AF Zagory, Jessica A.
   Golden, Jamie
   Holoyda, Kathleen
   Demeter, Natalie
   Nguyen, Nam X.
TI Excision and Primary Closure May Be the Better Option in the Surgical
   Management of Pilonidal Disease in the Pediatric Population
SO AMERICAN SURGEON
LA English
DT Article; Proceedings Paper
CT Annual Scientific Meeting of the Southern-California-Chapter of the
   American-College-of-Surgeons
CY JAN 15-17, 2016
CL Santa Barbara, CA
SP Amer Coll Surg, So Calif Chapter
ID VACUUM-ASSISTED CLOSURE; LIMBERG FLAP TECHNIQUE; CLEFT LIFT PROCEDURE;
   SINUS-DISEASE; RHOMBOID EXCISION; WOUND MANAGEMENT; LASER EPILATION;
   EXPERIENCE; ADOLESCENTS; DRAINAGE
AB The optimal management of pilonidal disease in the pediatric population is still debated. We conducted a retrospective review of patients 21 years old and younger who underwent surgical management for pilonidal disease between 2009 and 2013 at a single pediatric institution. Sixty patients (41.7% male) were included in the analysis, with a mean age of 15.0 years (range, 13-20). Twelve (20%) had a prior drainage procedure for pilonidal abscess before the definitive operative treatment. After excision to the presacral fascia, 36 (60%) had primary closure, 17 (28.3%) were left to heal by secondary intention, and 7 (11.7%) had flap closure. Overall recurrence rate was 41.7 per cent with 33.3 per cent in the primary, 58.8 per cent in the secondary, and 42.9 per cent in the flap group, respectively. Ten (16.7%) patients developed postoperative complications, which were similar among surgical groups, gender, and body mass index. The average length of stay was 0.67 (median 0, range, 0-5) days. Primary closure had the shortest length of stay (analysis of variance P = 0.04), and flap closure had no reoperations (analysis of variance P < 0.01). Pilonidal disease remains surgically challenging. Our data suggest that excision and primary closure is a better option in the pediatric population.
C1 [Zagory, Jessica A.; Golden, Jamie; Holoyda, Kathleen; Demeter, Natalie; Nguyen, Nam X.] Childrens Hosp Los Angeles, Dept Surg, 4650 Sunset Blvd,Mailstop 100, Los Angeles, CA 90027 USA.
C3 Children's Hospital Los Angeles
RP Nguyen, NX (通讯作者)，Childrens Hosp Los Angeles, Dept Surg, 4650 Sunset Blvd,Mailstop 100, Los Angeles, CA 90027 USA.
EM nanguyen@chla.usc.edu
RI Holoyda, Kathleen/KZU-2073-2024
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NR 34
TC 26
Z9 32
U1 0
U2 2
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD OCT
PY 2016
VL 82
IS 10
BP 964
EP 967
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EB7RY
UT WOS:000387589100023
PM 27779984
DA 2026-07-24
ER

PT J
AU Segers, P
   de Jong, AP
   Kloek, JJ
   Spanjaard, L
   de Mol, BAJM
AF Segers, P
   de Jong, AP
   Kloek, JJ
   Spanjaard, L
   de Mol, BAJM
TI Risk control of surgical site infection after cardiothoracic surgery
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE thoracic surgery; wound infection; risk; surveillance; topical negative
   pressure
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE INFECTIONS; MORTALITY; THERAPY;
   MORBIDITY; IMPACT
AB The purpose of this prospective study was to investigate whether a risk control programme based on risk assessment, new treatment modalities and the presence of a surveillance programme reduces the incidence of surgical, site infections (SSI). Between January 2001 and December 2003, 167 patients were treated for a total of 183 SSIs. Data were collected on pre-operative risk factors, intra-operative data and postoperative recovery, including complications, infecting organisms, SSI treatment techniques and length of hospital stay. In this series, the total incidence of SSI was 5.6%. The mean age of affected patients was 65.1 years with a range of 20-87 years. Mean intensive care and hospital. stay for SSI was 3.6 days and 18.8 days, respectively. Total mortality was 4.8%. Many risk factors were encountered, some of which were associated with a high morbidity. The majority of SSIs were treated by topical. negative pressure therapy (N=81), which gave few side-effects and good clinical. results. After starting the surveillance programme, a steady decline in prevalence was observed from 8.9% to 3.9%. This series adds to the evidence that SSI after cardiothoracic surgery is a major but mainly preventable cause of morbidity and mortality. Risk factor assessment, application of novel treatment modalities and an adequate surveillance system all increased patient safety. (c) 2005 The Hospital. Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands.
   Tech Univ Eindhoven, Dept Biomed Engn, Eindhoven, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Eindhoven
   University of Technology; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Segers, P (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM p.segers@amc.uva.nl
RI ; Segers, Patrick/IWM-4183-2023
OI de Mol, Bastian/0000-0001-6888-9430; 
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   Smyth STM, 2000, J HOSP INFECT, V45, P173, DOI 10.1053/jhin.2000.0736
   Tepaske R, 2001, LANCET, V358, P696, DOI 10.1016/S0140-6736(01)05836-6
   VANDENBRNK A, 1998, DUTCH J MED, V142, P2602
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   1999, HEALTHC HAZARD MAT M, V12, P1
NR 24
TC 12
Z9 15
U1 0
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD APR
PY 2006
VL 62
IS 4
BP 437
EP 445
DI 10.1016/j.jhin.2005.09.028
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 029II
UT WOS:000236555400006
PM 16455163
DA 2026-07-24
ER

PT J
AU Herbold, T
   Chon, SH
   Grimminger, P
   Maus, MKH
   Schmidt, H
   Fuchs, H
   Brinkmann, S
   Bludau, M
   Gutschow, C
   Schröder, W
   Hölscher, AH
   Leers, JM
AF Herbold, Till
   Chon, Seung-Hun
   Grimminger, Peter
   Maus, Martin K. H.
   Schmidt, Henner
   Fuchs, Hans
   Brinkmann, Sebastian
   Bludau, Marc
   Gutschow, Christian
   Schroeder, Wolfgang
   Hoelscher, Arnulf H.
   Leers, Jessica M.
TI Endoscopic Treatment of Transesophageal Echocardiography-Induced
   Esophageal Perforation
SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
LA English
DT Article
DE esophageal perforation; endoscopic therapy; esophageal injury;
   esophageal stents; esophagus surgery
ID VACUUM-ASSISTED CLOSURE; CASE SERIES; MANAGEMENT; COMPLICATIONS; STENT;
   LEAKS; DIAGNOSIS; EFFICACY; THERAPY; OPTIONS
AB Background: Perforation of the esophagus is the most severe complication of transesophageal echocardiography (TEE) and can lead to mediastinitis, pleural empyema, or peritonitis. Currently, the majority of patients receive operative treatment with only 6% treated endoscopically. We report our experience with endoscopic and conservative approaches. Methods: We retrospectively reviewed all patients treated for esophageal perforation and included all patients with perforation caused by TEE. All patients with perforation of the esophagus by TEE probe underwent conservative or endoscopic treatment, drainage of pleural and mediastinal retentions, and adjusted to antibiotic therapy. Results: From January 2004 to December 2014 a total of 109 patients were treated for esophageal perforation in our department. In 6 patients (5.5%) the perforation was caused by TEE. Location was cervical and midthoracic in 2 and 4 cases, respectively. All patients underwent successful endoscopic treatment and no further surgical procedure, such as esophageal suture or resection was necessary. The mean time between TEE and therapy of the perforation was 7.3 days. In all patients closure of the leakage could be achieved within 30 days. Mortality rate was 0%. Conclusions: Esophageal perforations caused by TEE are typically small, in the cervical and mid esophagus, and minimally contaminated. These are good prognostic factors for successful endoscopic treatment with preservation of the esophagus. Operative treatment should only be considered in cases of failed endoscopic treatment.
C1 [Herbold, Till] Univ Aachen, Dept Gen Visceral & Tumor Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
   [Herbold, Till; Chon, Seung-Hun; Maus, Martin K. H.; Fuchs, Hans; Brinkmann, Sebastian; Bludau, Marc; Schroeder, Wolfgang; Hoelscher, Arnulf H.; Leers, Jessica M.] Univ Cologne, Dept Gen Visceral Surg & Surg Oncol, Cologne, Germany.
   [Grimminger, Peter] Johannes Gutenberg Univ Mainz, Dept Gen Visceral & Transplant Surg, Mainz, Germany.
   [Schmidt, Henner; Gutschow, Christian] Univ Hosp Zurich, Dept Visceral & Transplant Surg, Zurich, Switzerland.
C3 RWTH Aachen University; University of Cologne; Johannes Gutenberg
   University of Mainz; University of Zurich; University Zurich Hospital
RP Herbold, T (通讯作者)，Univ Aachen, Dept Gen Visceral & Tumor Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
EM therbold@ukaachen.de
RI ; Grimminger, Peter/AFM-2285-2022; Schröder, Wolfgang/A-8799-2008; Chon,
   Seung-Hun/PHE-1824-2026; /AAP-2598-2021
OI Brinkmann, Sebastian/0000-0002-2901-6204; Grimminger,
   Peter/0000-0002-1859-9213; Chon, Seung-Hun/0000-0002-8923-6428; 
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   Wu JT, 2007, J TRAUMA, V63, P1173, DOI 10.1097/TA.0b013e31805c0dd4
NR 40
TC 6
Z9 8
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-6429
EI 1557-9034
J9 J LAPAROENDOSC ADV S
JI J. Laparoendosc. Adv. Surg. Tech.
PD APR
PY 2018
VL 28
IS 4
BP 422
EP 428
DI 10.1089/lap.2017.0559
EA JAN 2018
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GC2DO
UT WOS:000419869800001
PM 29327976
DA 2026-07-24
ER

PT J
AU Marinis, A
   Gkiokas, G
   Anastasopoulos, G
   Fragulidis, G
   Theodosopoulos, T
   Kotsis, T
   Mastorakos, D
   Polymeneas, G
   Voros, D
AF Marinis, Athanasios
   Gkiokas, Georgios
   Anastasopoulos, Georgios
   Fragulidis, Georgios
   Theodosopoulos, Theodosios
   Kotsis, Thomas
   Mastorakos, Dimitrios
   Polymeneas, George
   Voros, Dionisios
TI Surgical Techniques for the Management of Enteroatmospheric Fistulae
SO SURGICAL INFECTIONS
LA English
DT Article; Proceedings Paper
CT 21st Annual Congress of the Surgical-Infection-Society-Europe
CY MAY 01-03, 2008
CL Antalya, TURKEY
SP Surg Infect Soc Europe
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM PACK TECHNIQUE; OPEN ABDOMEN;
   EXPERIENCE; TRAUMA
AB Background: An intestinal fistula in the "open abdomen" is called "enteroatmospheric" and is a great challenge for the surgeon because of the high mortality and morbidity rates associated with it. This report is a study of the surgical strategy for treating patients with enteroatmospheric fistulae.
   Methods: During a 3-year period (2005-2007), two males and one female patient with a mean age of 63 years were referred to our surgical department for management of enteroatmospheric fistulae that developed after operations carried out for severe peritonitis, which was a consequence of sigmoid diverticulum rupture in two cases and disruption of an entero-enteric Roux-en-Y anastomosis after total gastrectomy for cancer in one.
   Results: All patients were appropriately supported in a surgical intensive care unit, with administration of total parenteral nutrition and appropriate antibiotics to eliminate secondary infections. Several re-operations were necessary to treat the enteroatmospheric fistulae. Eventually, all patients were discharged after a lengthy hospital stay (45-145 days).
   Conclusions: The essential principles of our operative strategy are: (1) early intervention; (2) a lateral surgical approach via the circumference of the open abdomen to avoid further damage to the exposed viscera; (3) excision of the involved bowel loop with an end-to-end anastomosis; (4) temporary abdominal closure and coverage of the open abdomen with an absorbable mesh, promoting tissue granulation; (5) skin grafting attempts; and (6) selective use of vacuum-assisted closure.
C1 [Marinis, Athanasios; Gkiokas, Georgios; Anastasopoulos, Georgios; Fragulidis, Georgios; Theodosopoulos, Theodosios; Kotsis, Thomas; Mastorakos, Dimitrios; Polymeneas, George; Voros, Dionisios] Univ Athens, Aretaie Univ Hosp, Dept Surg 2, Athens Med Sch, Athens 11528, Greece.
C3 National & Kapodistrian University of Athens
RP Voros, D (通讯作者)，Univ Athens, Aretaie Univ Hosp, Dept Surg 2, Athens Med Sch, 76 Vassilisis Sofias Ave, Athens 11528, Greece.
EM sakisdoc@yahoo.com
RI Gkiokas, Georgios/AAE-6312-2020; Marinis, Athanasios/AAO-2319-2020
OI Fragulidis, Georgios/0000-0001-6011-8674; Marinis,
   Athanasios/0000-0001-6423-6651
CR Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
   Bosscha K, 2000, EUR J SURG, V166, P44
   Demetriades D, 2003, J TRAUMA, V55, P999, DOI 10.1097/01.TA.0000082493.55763.27
   Girard S, 2002, AM J SURG, V184, P166, DOI 10.1016/S0002-9610(02)00916-9
   Goverman J, 2006, J TRAUMA, V60, P428, DOI 10.1097/01.ta.0000203588.66012.c4
   Schecter WP, 2006, J AM COLL SURGEONS, V203, P390, DOI 10.1016/j.jamcollsurg.2006.06.001
   Smith LA, 1997, AM SURGEON, V63, P1102
   Subramaniam MH, 2002, J TRAUMA, V53, P386, DOI 10.1097/00005373-200208000-00037
NR 8
TC 18
Z9 19
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD FEB
PY 2009
VL 10
IS 1
BP 47
EP 52
DI 10.1089/sur.2008.044
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Infectious Diseases; Surgery
GA 612DM
UT WOS:000278877000006
PM 19245361
DA 2026-07-24
ER

PT J
AU Akinci, OF
   Coskun, A
   Ozgonul, A
   Terzi, A
AF Akinci, O. F.
   Coskun, A.
   Ozgonul, A.
   Terzi, A.
TI Surgical treatment of complicated pilonidal disease: limited separate
   elliptical excision with primary closure
SO COLORECTAL DISEASE
LA English
DT Article
DE pilonidal sinus; complicated pilonidal disease; surgical treatment;
   primary closure; limited excision
ID VACUUM-ASSISTED CLOSURE; SINUS-DISEASE; SURGERY; EXPERIENCE; OPERATION
AB Objective We aimed at treating complicated pilonidal sinus (PS) patients by a simple and effective surgical procedure.
   Method Between 2000 and 2004, 24 selected complicated PS patients were treated with 'limited separate elliptical excision and primary closure'. Patients with extensive or bilateral gluteal involvement, having more lateral, caudal or cephalic sinuses, multiple recurrences and unhealed chronic wounds after pilonidal surgery were included. Asymmetric excision and primary closure was performed to main diseased tissue in the midline. Additionally, small separate elliptical excisions with primary closure were performed in other involved tissues. The fistula tract or granulation tissue were excised subcutaneously if present. All patients were operated under local anaesthesia. The fascial attachments between the skin and coccyx were released at the deep point in the midline and at one side of wound. Suction drains and prophylactic antibiotics were used; subcutaneous tissues were closed with running polyglactin sutures and skin with polypropylene subcutaneously.
   Results The mean age of patients was 28.4 years (range 18-38). The mean follow-up time was 2.8 years. One recurrence, one seroma, one wound infection and one wound breakdown were recorded. Healing was always by first intention except in patients with wound infection and breakdown.
   Conclusion Most of the complicated PS patients can be operated with acceptable rates of recurrences and complications by using 'limited separate elliptical excisions with primary closure'.
C1 Harran Univ, Fac Med, Dept Gen Surg, Istanbul, Turkey.
C3 Harran University
RP Akinci, OF (通讯作者)，Umraniye Educ & Res Hosp, Gen Surg Clin, Istanbul, Turkey.
EM ofarukakinci@yahoo.com
CR Akinci ÖF, 1999, EUR J SURG, V165, P339
   Akinci OF, 2000, DIS COLON RECTUM, V43, P701, DOI 10.1007/BF02235591
   Aysan E, 2004, EUR SURG RES, V36, P256, DOI 10.1159/000078861
   Bascom J, 2002, ARCH SURG-CHICAGO, V137, P1146, DOI 10.1001/archsurg.137.10.1146
   Dalenback J, 2004, Colorectal Dis, V6, P488, DOI 10.1111/j.1463-1318.2004.00693.x
   Gupta PJ, 2005, ACTA CHIR BELG, V105, P183, DOI 10.1080/00015458.2005.11679695
   Gurer A, 2005, DIS COLON RECTUM, V48, P1797, DOI 10.1007/s10350-005-0108-7
   Hull TL, 2002, SURG CLIN N AM, V82, P1169, DOI 10.1016/S0039-6109(02)00062-2
   KARYDAKIS GE, 1992, AUST NZ J SURG, V62, P385, DOI 10.1111/j.1445-2197.1992.tb07208.x
   Lynch JB, 2004, DIS COLON RECTUM, V47, P929, DOI 10.1007/s10350-004-0522-2
   Matsushita S, 2002, J DERMATOL, V29, P757, DOI 10.1111/j.1346-8138.2002.tb00217.x
   McGuinness JG, 2003, DIS COLON RECTUM, V46, P274, DOI 10.1007/s10350-004-6535-z
   Petersen S, 2002, DIS COLON RECTUM, V45, P1458, DOI 10.1007/s10350-004-6451-2
   Quinodoz PD, 1999, EUR J SURG, V165, P1061
   Sungurtekin H, 2003, J CLIN ANESTH, V15, P201, DOI 10.1016/S0952-8180(03)00032-1
   Taylor SA, 2003, RADIOLOGY, V226, P662, DOI 10.1148/radiol.2263011758
   Testini M, 2001, Colorectal Dis, V3, P427
   Theodoropoulos GE, 2003, DIS COLON RECTUM, V46, P1286, DOI 10.1007/s10350-004-6729-4
NR 18
TC 12
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD OCT
PY 2006
VL 8
IS 8
BP 704
EP 709
DI 10.1111/j.1463-1318.2006.01022.x
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 082QM
UT WOS:000240401900013
PM 16970582
OA Bronze
DA 2026-07-24
ER

PT J
AU Rosenthal, EL
   Blackwell, KE
   McGrew, B
   Carroll, WR
   Peters, GE
AF Rosenthal, EL
   Blackwell, KE
   McGrew, B
   Carroll, WR
   Peters, GE
TI Use of negative pressure dressings in head and neck reconstruction
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE fistula; head and neck cancer; wound care; negative pressure dressings;
   wound complications; otolaryngology; microvascular reconstruction; head
   and neck reconstruction
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background. Head and neck microvascular surgery commonly requires management of complex wounds of the upper aerodigestive tract and donor sites. Negative pressure dressings have been reported to promote healing in compromised wounds.
   Methods. Between February 2001 and June 2004, data were collected in a retrospective manner on 23 patients who underwent treatment with negative pressure dressings at two tertiary care institutions.
   Results. Twenty-three patients underwent negative pressure wound treatment for donor site complications (n = 9) or head and neck wounds (n = 14) with a minimum of 5 months follow-up. Average duration of treatment was 6.5 days. Indications for use in wound complications included wound breakdown (n = 3), fistula with carotid exposure (n = 4), tendon exposure of donor site (n = 6). and others (n = 3). On average, granulation tissue was promoted in across 93% of the wound bed over the course of treatment. Two patients with anterior mandibular hardware exposure were managed successfully with negative pressure dressings. Large split-thickness skin grafts (average size, 135 cm(2)) at mobile sites were bolstered with negative pressure dressings in seven patients with an overall take rate of 74%.
   Conclusion, Although of limited use as a bolster for split-thickness skin grafts, negative pressure dressings are safe and effective in the management of complex head and neck wounds and in the treatment of donor site complications. (c) 2005 Wiley Periodicals, Inc.
C1 Univ Alabama Birmingham, Dept Surg, Div Otolaryngol, Birmingham, AL 35294 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Div Head & Neck Surg, Los Angeles, CA USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Rosenthal, EL (通讯作者)，Univ Alabama Birmingham, Dept Surg, Div Otolaryngol, BDB Suite 563,1530 3rd Ave S, Birmingham, AL 35294 USA.
EM Eben.rosenthal@ccc.uab.edu
RI Rosenthal, Eben/KLC-3513-2024
OI Rosenthal, Eben/0000-0003-0294-5203
CR Alvarez AA, 2001, GYNECOL ONCOL, V80, P413, DOI 10.1006/gyno.2000.6092
   Avery C, 2000, INT J ORAL MAX SURG, V29, P198, DOI 10.1016/S0901-5027(00)80092-2
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Chang KP, 2001, BURNS, V27, P839, DOI 10.1016/S0305-4179(01)00052-3
   Cro C, 2002, POSTGRAD MED J, V78, P364, DOI 10.1136/pmj.78.920.364
   Isago T, 2003, J DERMATOL, V30, P673, DOI 10.1111/j.1346-8138.2003.tb00456.x
   Mendez-Eastman S, 1998, Plast Surg Nurs, V18, P27
   Nienhuijs S W, 2003, J Wound Care, V12, P343
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Sibbald R Gary, 2003, Ostomy Wound Manage, V49, P52
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
NR 11
TC 29
Z9 34
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD NOV
PY 2005
VL 27
IS 11
BP 970
EP 975
DI 10.1002/hed.20265
PG 6
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 977TL
UT WOS:000232826000007
PM 16127668
DA 2026-07-24
ER

PT J
AU Cresti, S
   Ouaïssi, M
   Sielezneff, I
   Chaix, JB
   Pirro, N
   Berthet, B
   Consentino, B
   Sastre, B
AF Cresti, Silvia
   Ouaissi, Mehdi
   Sielezneff, Igor
   Chaix, Jean-Baptiste
   Pirro, Nicolas
   Berthet, Bruno
   Consentino, Bernard
   Sastre, Bernard
TI Advantage of vacuum assisted closure on healing of wound associated with
   omentoplasty after abdominoperineal excision: a case report
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
ID FLAP RECONSTRUCTION; RESECTION; TRIAL; ADENOCARCINOMA; COMPLICATIONS;
   DEFECTS; RECTUM
AB Background: Primary closure of the perineum with drainage after abdominoperineal excision of the rectum for carcinoma, is widely accepted. However hematoma, perineal abscess and reoperation are significantly more frequent after primary closure than after packing of the perineal cavity. Those complications are frequently related to the patients' clinical antecedent (i.e radiotherapy, diabetes, smoking).
   Case presentation: In the present report, vacuum assisted drainage was used after abdominoperineal excision for carcinoma in the very first step due to intraoperative gross septic contamination during tumor resection. The first case: A 57-years old man with a 30-years history of peri-anal Crohn's disease, the adenocarcinoma of the lowest part of the rectum and Crohn colitis with multiple area of severe dysplasia required panproctocolectomy with a perineal resection. The VAC system was used during 12 days (changed every 3 days). We observed complete healing 18 days after surgery. The second case: A 51-year-old man, with AIDS. An abdominoperineal resection was performed for recurrence epidermoid anal cancer. The patient was discharged at day 25 and complete healing was achieved 30 days later after surgery.
   Conclusion: The satisfactory results showed in the present report appear to be favored by association of omentoplasty and VAC system. Those findings led us to favor VAC system in the case of pelvic exenteration associated with high risk of infection.
C1 [Cresti, Silvia; Ouaissi, Mehdi; Sielezneff, Igor; Chaix, Jean-Baptiste; Pirro, Nicolas; Berthet, Bruno; Consentino, Bernard; Sastre, Bernard] Hop Enfants La Timone, Serv Chirurg Digest & Oncol, Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Ouaïssi, M (通讯作者)，Hop Enfants La Timone, Serv Chirurg Digest & Oncol, Marseille, France.
EM sylvia.cresti@mail.ap-hm.fr; mehdi.ouaissi@mail.ap-hm.fr;
   igor.sielezneff@mail.ap.hm.fr; jeanbaptiste.chaix@mail.ap-hm.fr;
   nicolas.pirro@mail.ap-hm.fr; brunot.berthet@mail.ap.fr;
   bernard.consentino@mail.ap-hm.fr; bernard.sastre@mail.ap.hm.fr
RI CHAIX, Jordane/MXM-3911-2025; /HPF-7453-2023
FU Assistance Publique des Hopitaux de Marseille; Faculte de Medecine de
   Marseille
FX This work was supported by Assistance Publique des Hopitaux de Marseille
   and Faculte de Medecine de Marseille.
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NR 15
TC 15
Z9 23
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD DEC 23
PY 2008
VL 6
AR 136
DI 10.1186/1477-7819-6-136
PG 5
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 395NU
UT WOS:000262531600001
PM 19102785
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Huisman, JF
   van Westreenen, HL
   van der Wouden, EJ
   Vasen, HFA
   de Graaf, EJR
   Doornebosch, PG
   Tang, TJ
   Schot, I
   Brohet, RM
   Cappel, WHDTN
   Vermaas, M
AF Huisman, J. F.
   van Westreenen, H. L.
   van der Wouden, E. J.
   Vasen, H. F. A.
   de Graaf, E. J. R.
   Doornebosch, P. G.
   Tang, T. J.
   Schot, I.
   Brohet, R. M.
   Cappel, W. H. de Vos Tot Nederveen
   Vermaas, M.
TI Effectiveness of endosponge therapy for the management of presacral
   abscesses following rectal surgery
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Article
DE Rectal neoplasms; Anastomotic leak; Endosponge; Patient reported outcome
   measures; LARS score
ID LOW ANTERIOR RESECTION; VACUUM-ASSISTED CLOSURE; ENDO-SPONGE TREATMENT;
   ANASTOMOTIC LEAKAGE; CANCER; SINUS; RISK
AB Background Anastomotic leak after rectal surgery is reported in 9% (range 3-28%) of patients. The aim of our study was to evaluate the effectiveness of endosponge therapy for anastomotic. Endpoints were the rate of restored continuity and the functional bowel outcome after anastomotic leakage. Methods This was a multicenter retrospective observational cohort study. All patients with symptomatic anastomotic leakage after rectal surgery who had endosponge therapy between January 2012 and August 2017 were included. Functional bowel outcome was measured using the low anterior resection syndrome (LARS) score system. Results Twenty patients were included. Eighteen patients had low anterior resection (90%) for rectal cancer. A diverting ileostomy was performed at primary surgical intervention in 14 patients (70%). Fourteen patients (70%) were treated with neoadjuvant (chemo-)radiotherapy. The median time between primary surgical intervention and first endosponge placement was 21 (5-537) days. The median number of endosponge changes was 9 (2-28). The success rate of the endosponge treatment was 88% and the restored gastrointestinal continuity rate was 73%. A chronic sinus occurred in three patients (15%). All patients developed LARS, of which 77% reported major LARS. Conclusions Endosponge therapy is an effective treatment for the closure of presacral cavities with high success rate and leading to restored gastrointestinal continuity in 73%. However, despite endosponge therapy many patients develop major LARS.
C1 [Huisman, J. F.; van der Wouden, E. J.; Cappel, W. H. de Vos Tot Nederveen] Isala, Dept Gastroenterol & Hepatol, Zwolle, Netherlands.
   [van Westreenen, H. L.] Isala, Dept Surg, Zwolle, Netherlands.
   [Vasen, H. F. A.] Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands.
   [de Graaf, E. J. R.; Doornebosch, P. G.; Vermaas, M.] IJsselland Hosp, Dept Surg, Capelle aan den IJssel, Netherlands.
   [Tang, T. J.; Schot, I.] IJsselland Hosp, Dept Gastroenterol & Hepatol, Capelle aan den IJssel, Netherlands.
   [Brohet, R. M.] Isala, Dept Epidemiol & Stat, Zwolle, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC)
RP Huisman, JF (通讯作者)，Isala, Dept Gastroenterol & Hepatol, Zwolle, Netherlands.
EM j.f.huisman@isala.nl
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NR 19
TC 17
Z9 18
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUN
PY 2019
VL 23
IS 6
BP 551
EP 557
DI 10.1007/s10151-019-02007-9
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA IN6DE
UT WOS:000478766000005
PM 31338710
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Waibel, BH
   Rotondo, MF
AF Waibel, Brett H.
   Rotondo, Michael F.
TI Damage control in trauma and abdominal sepsis
SO CRITICAL CARE MEDICINE
LA English
DT Article
DE damage control; resuscitation; abdominal wounds; sepsis; trauma
ID VACUUM-ASSISTED CLOSURE; RECOMBINANT-FACTOR-VIIA; RED-BLOOD-CELLS;
   INTENSIVE INSULIN THERAPY; ACELLULAR DERMAL MATRIX; MULTIPLE ORGAN
   FAILURE; FRESH-FROZEN PLASMA; OPEN ABDOMEN; COMPARTMENT SYNDROME; FLUID
   RESUSCITATION
AB Damage control surgery, initially formalized <20 yrs ago, was developed to overcome the poor outcomes in exsanguinating abdominal trauma with traditional surgical approaches. The core concepts for damage control of hemorrhage and contamination control with abbreviated laparotomy followed by resuscitation before definitive repair, although simple in nature, have led to an alteration in which emergent surgery is handled among a multitude of problems, including abdominal sepsis and battlefield surgery. With the aggressive resuscitation associated with damage control surgery, understanding of abdominal compartment syndrome has expanded. It is probably through avoiding this clinical entity that the greatest improvement in surgical outcomes for various emergent surgical problems has occurred in the past two decades. However, with its success, new problems have emerged, including increases in enterocutaneous fistulas and open abdomens. But as with any crisis, innovative strategies are being developed. New approaches to control of the open abdomen and reconstruction of the abdominal wall are being developed from negative pressure dressing therapies to acellular allograft meshes. With further understanding of new resuscitative strategies, the need for damage control surgery may decline, along with its concomitant complications, at the same time retaining the success that damage control surgery has brought to the critically ill trauma and general surgery patient in the past few years. (Crit Care Med 2010; 38[Suppl.]:S421-S430)
C1 [Waibel, Brett H.; Rotondo, Michael F.] E Carolina Univ, Dept Surg, Brody Sch Med, Div Trauma & Surg Crit Care, Greenville, NC 27858 USA.
C3 University of North Carolina; East Carolina University
RP Waibel, BH (通讯作者)，E Carolina Univ, Dept Surg, Brody Sch Med, Div Trauma & Surg Crit Care, Greenville, NC 27858 USA.
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NR 169
TC 60
Z9 71
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0090-3493
EI 1530-0293
J9 CRIT CARE MED
JI Crit. Care Med.
PD SEP
PY 2010
VL 38
IS 9
SU S
BP S421
EP S430
DI 10.1097/CCM.0b013e3181ec5cbe
PG 10
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 647FB
UT WOS:000281602100003
PM 20724875
DA 2026-07-24
ER

PT J
AU Singh, MK
   Rocca, JP
   Rochon, C
   Facciuto, ME
   Sheiner, PA
   Rodriguez-Davalos, MI
AF Singh, M. K.
   Rocca, J. P.
   Rochon, C.
   Facciuto, M. E.
   Sheiner, P. A.
   Rodriguez-Davalos, M. I.
TI Open Abdomen Management With Human Acellular Dermal Matrix in Liver
   Transplant Recipients
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID ABDOMINAL-WALL; CLOSURE; SAFE
AB Background. Abdominal wall closure after liver transplantation is not always feasible and may result in increased intra-abdominal pressure along with associated complications. Various temporary Closure techniques as well as open wound management have been used to address this complex problem. The aim of this series was to describe an approach to definitive wound closure of the open abdomen in liver transplant patients.
   Methods. We performed a retrospective review of all liver transplant patients at our institution from September 2005 to November 2007. The management of the open abdomen in 10 liver transplant patients was reviewed, and a novel approach described to manage these defects.
   Results. Ten patients with open wounds were closed during the study period using human acellular dermal matrix (HADM). There were 7 men and 3 women of median age 55 years. Average size of HADM was 235 cm(2). The median follow-up is,10 months with no incidence of evisceration or hernia. In 1 patient, the graft failed along the lateral side due to infection; it dislodged during vacuum-assisted closure dressing change in another patient at 5 months after closure. Fascial closure was not possible due to organ edema (n = 3), a large liver (n = 4) or wound infection with dehiscence (n = 3).
   Conclusions. RADM can be used for primary wound closure in both clean and contaminated wounds as an alternative to an open abdomen post-liver transplantation.
C1 [Singh, M. K.; Rocca, J. P.; Rochon, C.; Facciuto, M. E.; Sheiner, P. A.; Rodriguez-Davalos, M. I.] Westchester Med Ctr, Dept Hepatobiliary & Liver Transplant, Valhalla, NY USA.
C3 Westchester Medical Center
RP Singh, MK (通讯作者)，Transplant Ctr, BHC A Wing,95 Grasslands Rd, Valhalla, NY 10595 USA.
EM msingh78@gmail.com
RI ; /AAM-6817-2021; Rocca, Juan/AAU-3771-2020
OI Singh, Manoj/0000-0002-1909-1745; 
CR An G, 2004, J TRAUMA, V56, P1266, DOI 10.1097/01.TA.0000068241.66186.00
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NR 12
TC 22
Z9 30
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD DEC
PY 2008
VL 40
IS 10
BP 3541
EP 3544
DI 10.1016/j.transproceed.2008.06.105
PG 4
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA 389ZE
UT WOS:000262133300061
PM 19100433
DA 2026-07-24
ER

PT J
AU Toong, LY
   Ghauth, S
   Ong, YP
   Zulkiflee, A
AF Toong, Liew Yew
   Ghauth, Sakina
   Ong, Yazid Pol
   Zulkiflee, Abu Bakar
TI Drainage of Severe Descending Mediastinitis: 5-Year Experience in a
   Single Tertiary Institution
SO B-ENT
LA English
DT Article
DE Case series; deep neck space infection; descending mediastinitis;
   transcervical; vacuum-assisted dressing
ID VACUUM-ASSISTED CLOSURE; NECROTIZING MEDIASTINITIS; MANAGEMENT;
   DIAGNOSIS; THERAPY
AB Objective: Descending necrotizing mediastinitis is caused by the spread of the infection to the mediastinum from the deep and superficial cervical fascial planes. Surgical drainage of severe descending necrotizing mediastinitis was done through an invasive transthoracic and transcervical approach. In this study, we described a series of severe descending necrotizing mediastinitis treated with the only transcervical approach with or without vacuum-assisted dressing.
   Methods: A retrospective, single-institution study was performed to evaluate the outcome of patients with descending necrotizing mediastinitis managed from June 2015 until March 2020.
   Results: A total of 5 patients were identified. All subjects underwent transcervical drainage of descending necrotizing mediastinitis. Vacuumassisted dressing was applied to 3 patients.
   One subject belonged to type I, and there were 2 each for type Ila and I lb according to Endo et al's3 computed tomography classification. All patients survived with only transcervical drainage, without the invasive transthoracic approach. The mean duration from the time of admission to surgical drainage was 10.3 hours. The mean length of the vacuum-assisted dressing application was 11 days. All patients were discharged from the hospital, with complete resolution of disease.
   Conclusion: Less invasive transcervical drainage may be adequate in treating severe descending necrotizing mediastinitis, as long as early treatment is recognized and initiated. Incorporating vacuum-assisted dressing in the treatment course may open the door for a new algorithm.
C1 [Toong, Liew Yew; Ghauth, Sakina; Ong, Yazid Pol; Zulkiflee, Abu Bakar] Univ Malaya, Dept Otolaryngol, Med Ctr, Kuala Lumpur, Malaysia.
C3 Universiti Malaya
RP Toong, LY (通讯作者)，Univ Malaya, Dept Otolaryngol, Med Ctr, Kuala Lumpur, Malaysia.
EM lyewtoong@yahoo.com
RI AB, Zulkiflee/B-9142-2010; Ghauth, Sakina/JNF-0194-2023; Liew, Yew
   Toong/AAA-6977-2022
OI AB, Zulkiflee/0000-0002-1019-1408; Ghauth, Sakina/0000-0002-6179-7055;
   Liew, Yew Toong/0000-0002-7625-9006
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NR 26
TC 0
Z9 0
U1 1
U2 7
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, Turkiye
EI 2684-4907
J9 B-ENT
JI B-ENT
PD JAN
PY 2022
VL 18
IS 1
BP 21
EP 27
DI 10.5152/B-ENT.2022.21570
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 0Z3WL
UT WOS:000791011200004
OA gold
DA 2026-07-24
ER

PT J
AU Panko, S
   Vakulich, D
   Karpitski, A
   Zhurbenka, H
   Shestiuk, A
   Boufalik, R
   Ihnatsiuk, A
AF Panko, Siarhei
   Vakulich, Denis
   Karpitski, Aliaksandr
   Zhurbenka, Henadzi
   Shestiuk, Andrej
   Boufalik, Rostislav
   Ihnatsiuk, Aliaksandr
TI Intrathoracic negative pressure therapy and/or endobronchial valve for
   pleural empyema minimal invasive management: case series of thirteen
   patients and review of the literature
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Review
DE bronchopleural fistula; video-assisted thoracoscopic surgery; empyema;
   intrathoracic negative pressure therapy; endobronchial valve
ID VACUUM-ASSISTED CLOSURE
AB Introduction: Intrathoracic negative pressure therapy is an adjunct to standard methods of complex empyema management in debilitated patients. Nevertheless, the use of endoscopic one-way endobronchial valves to successfully close large bronchopleural fistulas in patients with advanced pleural empyema has been described in only a few case reports.
   Aim: To present our experience in managing complex pleural empyema using thoracostomy with intrathoracic negative pressure therapy and/or endobronchial valve implantation.
   Material and methods: We retrospectively analyzed data from 13 consecutive patients (11 men, mean age: 56 years, range: 38-80 years) who were treated for pleural empyema using thoracostomy with intrathoracic negative pressure therapy and/or endobronchial valve implantation between October 2015 and November 2017.
   Results: The control of empyema was satisfactory in 12 patients; however, 1 patient died from sepsis-related multi-organ failure despite complete cessation of air leak on day 9 after endobronchial valve implantation. The overall success rate for the final closure of the chest wall was 9/12 patients (75%): in 5 patients, the wall closed spontaneously, and in 4, the wall was closed using thoracomyoplasty.
   Conclusions: Thoracostomy with intrathoracic negative pressure therapy, endobronchial valve implantation with tube drainage, and a combination of the two could adequately manage patients with pleural empyema with or without a persistent air leakage fistula.
C1 [Panko, Siarhei] Jan Kochanowski Univ Humanities & Sci, Fac Hlth Sci, Al 9 Wiekow Kielc 19, Kielce, Poland.
   [Vakulich, Denis; Karpitski, Aliaksandr; Zhurbenka, Henadzi; Boufalik, Rostislav; Ihnatsiuk, Aliaksandr] Brest Reg Hosp, Dept Thorac Surg, Brest, BELARUS.
   [Shestiuk, Andrej] Brest State Univ, Dept Anat & Physiol, Brest, BELARUS.
C3 Jan Kochanowski University; A.S. Pushkin Brest State University
RP Panko, S (通讯作者)，Jan Kochanowski Univ Humanities & Sci, Fac Hlth Sci, Al 9 Wiekow Kielc 19, Kielce, Poland.
EM sppankam@gmail.com
RI ; Panko, Siarhei/AAD-1639-2020
OI Vakulich, DZIANIS/0000-0003-3451-2437; Panko,
   Siarhei/0000-0001-8665-2832
CR Ding M, 2017, RESP RES, V18, DOI 10.1186/s12931-017-0666-y
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NR 21
TC 3
Z9 4
U1 0
U2 2
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 4
BP 588
EP 595
DI 10.5114/wiitm.2020.93210
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QD6LA
UT WOS:000615625900009
PM 33294074
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Riss, S
   Stift, A
   Kienbacher, C
   Dauser, B
   Haunold, I
   Kriwanek, S
   Radlsboek, W
   Bergmann, M
AF Riss, Stefan
   Stift, Anton
   Kienbacher, Caroline
   Dauser, Bernhard
   Haunold, Ingrid
   Kriwanek, Stefan
   Radlsboek, Wolfgang
   Bergmann, Michael
TI Recurrent abscess after primary successful endo-sponge treatment of
   anastomotic leakage following rectal surgery
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Rectal surgery; Anastomotic leakage; Endo-sponge; Endo-vacuum treatment
ID VACUUM-ASSISTED CLOSURE; COLORECTAL-CANCER; CURATIVE RESECTION; ANTERIOR
   RESECTION; LOCAL RECURRENCE; SURVIVAL; IMPACT; COMPLICATIONS; THERAPY;
   ETVARD
AB AIM: To assess long-term efficacy of initially successful endo-sponge assisted therapy.
   METHODS: Between 2006 and 2009, consecutive patients who had undergone primary successful endosponge treatment of anastomotic leakage following rectal cancer surgery were enrolled in the study. Patients were recruited from 6 surgical departments in Vienna. Clinical and oncologic outcomes were assessed through routine endoscopic and radiologic follow-up examination.
   RESULTS: Twenty patients (7 female, 13 male) were included. The indications for endo-sponge treatment were anastomotic leakage (n = 17) and insufficiency of a rectal stump after Hartmann's procedure (n = 3). All patients were primarily operated for rectal cancer. The overall mortality rate was 25%. The median follow-up duration was 17 mo (range 1.5-29.8 mo). Five patients (25%) developed a recurrent abscess. Median time between last day of endo-sponge therapy and occurrence of recurrent abscess was 255 d (range 21-733 d). One of these patients was treated by computed tomography-guided drainage and in 3 patients Hartmann's procedure had to be performed. Two patients (10%) developed a local tumor recurrence and subsequently died.
   CONCLUSION: Despite successful primary outcome, patients who receive endo-sponge therapy should be closely monitored in the first 2 years, since recurrence might occur. (C) 2010 Baishideng. All rights reserved.
C1 [Riss, Stefan; Stift, Anton; Bergmann, Michael] Med Univ Vienna, Div Gen Surg, Dept Surg, A-1090 Vienna, Austria.
   [Kienbacher, Caroline] Floridsdorf Hosp, Dept Surg, A-1210 Vienna, Austria.
   [Dauser, Bernhard] Barmherzige Bruder Wien, Dept Surg, A-1020 Vienna, Austria.
   [Haunold, Ingrid] Barmherzige Schwestern Wien, Dept Surg, A-1060 Vienna, Austria.
   [Kriwanek, Stefan] Rudolfstiftung Hosp, Dept Surg, A-1030 Vienna, Austria.
   [Radlsboek, Wolfgang] Gottlicher Heiland Wien, Dept Surg, A-1170 Vienna, Austria.
C3 Medical University of Vienna; Konventhospital Der Barmherzigen Bruder;
   Rudolfstiftung Hospital
RP Riss, S (通讯作者)，Med Univ Vienna, Div Gen Surg, Dept Surg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM stefan.riss@meduniwien.ac.at
RI Bergmann, Michael/GZK-7700-2022
OI Bergmann, Michael/0000-0001-8529-1166; Stift, Anton/0000-0002-7243-8138
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NR 22
TC 36
Z9 37
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 28
PY 2010
VL 16
IS 36
BP 4570
EP 4574
DI 10.3748/wjg.v16.i36.4570
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 655PG
UT WOS:000282261300011
PM 20857528
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Desai, SC
   Sand, JP
   Sharon, JD
   Branham, G
   Nussenbaum, B
AF Desai, Shaun C.
   Sand, Jordan P.
   Sharon, Jeffrey D.
   Branham, Gregory
   Nussenbaum, Brian
TI Scalp Reconstruction An Algorithmic Approach and Systematic Review
SO JAMA FACIAL PLASTIC SURGERY
LA English
DT Review
ID TRAPEZIUS MYOCUTANEOUS FLAP; VACUUM-ASSISTED CLOSURE; FREE-TISSUE
   TRANSFER; ARTIFICIAL DERMIS; SURGICAL ANATOMY; COMPLEX SCALP; LARGE
   DEFECTS; SKIN-GRAFT; NECK; HEAD
AB IMPORTANCE Reconstruction of the scalp after acquired defects remains a common challenge for the reconstructive surgeon, especially in a patient with a history of radiation to the area
   OBJECTIVE To review the current literature and describe a novel algorithm to help guide the reconstructive surgeon in determining the optimal reconstruction from a cosmetic and functional standpoint. Pertinent surgical anatomy, considerations for patient and technique selection, reconstructive goals, as well as the reconstructive ladder, are also discussed.
   EVIDENCE REVIEW A PubMed and Medline search was performed of the entire English literature with respect to scalp reconstruction. Priority of review was given to those studies with higher-quality levels of evidence.
   FINDINGS Size, location, radiation history, and Potential for hairline distortion are important factors in determining the ideal reconstruction. The tighter and looser areas of the scalp play a major role in the potential for primary or local flap closure. Patients with medium to large defects and a history of radiation will likely benefit from free tissue transfer.
   CONCLUSIONS AND RELEVANCE Ideal reconstruction of scalp defects relies on a comprehensive understanding of scalp anatomy, a full consideration of the armamentarium of surgical techniques, and a detailed appraisal of patient factors and expectations. The simplest reconstruction should be used whenever possible to provide the most functional and aesthetic scalp reconstruction, with the least amount of complexity.
C1 [Desai, Shaun C.; Sand, Jordan P.; Sharon, Jeffrey D.; Branham, Gregory; Nussenbaum, Brian] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Nussenbaum, B (通讯作者)，Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA.
EM nussenbaumb@ent.wustl.edu
RI ; Branham, Gregory/ABB-6607-2021
OI Sharon, Jeffrey/0000-0003-4892-5064; 
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NR 77
TC 159
Z9 194
U1 0
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6076
EI 2168-6092
J9 JAMA FACIAL PLAST SU
JI JAMA Facial Plast. Surg.
PD JAN-FEB
PY 2015
VL 17
IS 1
BP 56
EP 66
DI 10.1001/jamafacial.2014.889
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE0JK
UT WOS:000351490100011
PM 25375669
DA 2026-07-24
ER

PT J
AU Fitzgerald, JEF
   Gupta, S
   Masterson, S
   Sigurdsson, HH
AF Fitzgerald, James E. F.
   Gupta, Shradha
   Masterson, Sarah
   Sigurdsson, Helgi H.
TI Laparostomy management using the ABThera™ open abdomen negative pressure
   therapy system in a grade IV open abdomen secondary to acute
   pancreatitis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Acute pancreatitis; Laparostomy; Negative pressure therapy; Open
   abdomen; Vacuum dressing
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; RANDOMIZED
   CONTROLLED-TRIAL; INTRAABDOMINAL HYPERTENSION; INTERNATIONAL-CONFERENCE;
   SUBATMOSPHERIC PRESSURE; DIFFUSE PERITONITIS; FASCIAL CLOSURE; WOUNDS;
   ETAPPENLAVAGE
AB Wound control in laparostomy for the treatment of intra-abdominal hypertension remains challenging and numerous techniques have been described. We report the first UK experience with a new commercially available device specifically designed to facilitate management of the open abdomen. A 44-year-old gentleman presented with a 3-day history of constant severe epigastric pain and associated vomiting. Amylase was markedly elevated and he was admitted for supportive management of pancreatitis, with subsequent transfer to intensive care due to severe systemic inflammatory syndrome. The patient decompensated, developing intra-abdominal hypertension with renal and respiratory failure. This was successfully managed by performing a laparostomy and using an ABThera Open Abdomen Negative Pressure Therapy System (KCI, San Antonio, TX). We describe its use to facilitate wound control, including enteroatmospheric fistula, allowing granulation and eventual restoration of gastrointestinal continuity 383-days after admission. We found the ABThera System proved to be a useful treatment adjunct, protecting intra-abdominal contents while removing large volumes of exudate and infected material from within the abdominal cavity. Complex cases such as this remain infrequent and this article provides a summary of our experience, including a review of indications for laparostomy and the underlying basic science in this difficult area.
C1 [Fitzgerald, James E. F.; Gupta, Shradha; Sigurdsson, Helgi H.] Chelsea & Westminster NHS Hosp Trust, Dept Gen Surg, London SW10 9NH, England.
   [Masterson, Sarah] Chelsea & Westminster NHS Hosp Trust, Tissue Viabil Serv, London SW10 9NH, England.
RP Fitzgerald, JEF (通讯作者)，Chelsea & Westminster NHS Hosp Trust, Dept Gen Surg, 369 Fulham Rd, London SW10 9NH, England.
EM edwardfitzgerald@doctors.org.uk
RI Fitzgerald, James/F-2565-2013
OI Fitzgerald, James/0000-0002-4453-5117
FU Kinetic Concepts Inc.
FX Figure 1 ABThera (TM) Open Abdomen Negative Pressure Therapy System,
   Courtesy of KCI Licensing, Inc. J. E. F. F. has received speaker fees
   for the presentation of this case since the manuscript was prepared from
   Kinetic Concepts Inc.
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NR 36
TC 16
Z9 23
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2013
VL 10
IS 2
BP 138
EP 144
DI 10.1111/j.1742-481X.2012.00953.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 112DB
UT WOS:000316571100005
PM 22487377
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Weidenhagen, R
   Grützner, KU
   Kopp, R
   Spelsberg, FW
   Jauch, KW
AF Weidenhagen, R
   Grützner, KU
   Kopp, R
   Spelsberg, FW
   Jauch, KW
TI Role of vacuum therapy in the management of the septic abdomen
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE peritonitis; vacuum therapy; open abdomen; vacuum assisted closure;
   anastomotic leakage
ID TEMPORARY ABDOMINAL CLOSURE; ASSISTED CLOSURE; ENTEROCUTANEOUS FISTULA;
   FASCIAL CLOSURE; VENTRAL HERNIA; PACK TECHNIQUE; SURGERY; EXPERIENCES;
   PERITONITIS; SEPSIS
AB Progress in intensive care medicine contributed substantially in lowering the mortality rate of patients suffering from diffuse secondary peritonitis. In the medical care of patients presenting a septic abdomen the persisting septic focus is one of the greatest problems. This is associated with other problems like temporary closure of the abdomen, complications due to re-laparotomies, healing of the abdominal wall after soft tissue infection, loss of abdominal wall musculature, or persisting enteral fistulas. The vacuum therapy is used with increasing frequency for the treatment of septic complications in different areas of the body. The excellent drainage characteristics of the vacuum therapy appear to be a therapeutic option for the control of surgically untreatable septic processes in the abdominal cavity. More and more experience is gathered with the successful treatment of enterocutaneous fistulas, small intestine and pancreatic fistulas as well as anastomotic leakage after rectal surgery. There exist hardly any evidence-based recommendations for the application of vacuum therapy for treatment of the septic abdomen. But the good results of temporary closure of open abdomen of trauma patients by the vacuum therapy arises hope that the results can be transferred to the treatment modalities of persisting peritonitis. Additionally, these patients could profit from the drainage characteristics of the vacuum therapy.
C1 Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, D-81377 Munich, Germany.
C3 University of Munich
RP Weidenhagen, R (通讯作者)，Univ Munich, Klinikum Grosshadern, Chirurg Klin & Poliklin, Marchioninistr 15, D-81377 Munich, Germany.
EM rolf.weidenhagen@med.uni-muenchen.de
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NR 43
TC 16
Z9 17
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S115
EP S119
DI 10.1055/s-2006-921512
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100027
PM 16575660
DA 2026-07-24
ER

PT J
AU Norman, G
   Goh, EL
   Dumville, JC
   Shi, CH
   Liu, ZM
   Chiverton, L
   Stankiewicz, M
   Reid, A
AF Norman, Gill
   Goh, En Lin
   Dumville, Jo C.
   Shi, Chunhu
   Liu, Zhenmi
   Chiverton, Laura
   Stankiewicz, Monica
   Reid, Adam
TI Negative pressure wound therapy for surgical wounds healing by primary
   closure
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SITE INFECTION;
   CESAREAN-SECTION; COST-EFFECTIVENESS; CLINICAL-EFFICACY; TISSUE
   EXPANSION; CARDIAC-SURGERY; CLOSED SUCTION; PRIMARY HIP
AB Background
   Indications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). Existing evidence for the effectiveness of NPWT on postoperative wounds healing by primary closure remains uncertain.
   Objectives
   To assess the effects of NPWT for preventing SSI in wounds healing through primary closure, and to assess the cost-effectiveness of NPWT in wounds healing through primary closure.
   Search methods
   In June 2019, we searched the Cochrane Wounds Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE (including In-Process & Other Non-Indexed Citations); Ovid Embase and EBSCO CINAHL Plus. We also searched clinical trials registries and references of included studies, systematic reviews and health technology reports. There were no restrictions on language, publication date or study setting.
   Selection criteria
   We included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another type of NPWT.
   Data collection and analysis
   At least two review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, assessment using the Cochrane 'Risk of bias' tool, and quality assessment according to Grading of Recommendations, Assessment, Development and Evaluations methodology.
   Main results
   In this third update, we added 15 new randomised controlled trials (RCTs) and three new economic studies, resulting in a total of 44 RCTs (7447 included participants) and five economic studies. Studies evaluated NPWT in the context of a wide range of surgeries including orthopaedic, obstetric, vascular and general procedures. Economic studies assessed NPWT in orthopaedic, obstetric and general surgical settings. All studies compared NPWT with standard dressings. Most studies had unclear or high risk of bias for at least one key domain.
   Primary outcomes
   Four studies (2107 participants) reported mortality. There is low-certainty evidence (downgraded twice for imprecision) showing no clear difference in the risk of death after surgery for people treated with NPWT (2.3%) compared with standard dressings (2.7%) (risk ratio (RR) 0.86; 95% confidence interval (CI) 0.50 to 1.47; I-2 = 0%). Thirty-nine studies reported SSI; 31 of these (6204 participants), were included in meta-analysis. There is moderate-certainty evidence (downgraded once for risk of bias) that NPWT probably results in fewer SSI (8.8% of participants) than treatment with standard dressings (13.0% of participants) after surgery; RR 0.66 (95% CI 0.55 to 0.80; I-2 = 23%). Eighteen studies reported dehiscence; 14 of these (3809 participants) were included in meta-analysis. There is low-certainty evidence (downgraded once for risk of bias and once for imprecision) showing no clear difference in the risk of dehiscence after surgery for NPWT (5.3% of participants) compared with standard dressings (6.2% of participants) (RR 0.88, 95% CI 0.69 to 1.13; I-2 = 0%).
   Secondary outcomes
   There is low-certainty evidence showing no clear difference between NPWT and standard treatment for the outcomes of reoperation and incidence of seroma. For reoperation, the RR was 1.04 (95% CI 0.78 to 1.41; I-2 = 13%; 12 trials; 3523 participants); for seroma, the RR was 0.72 (95% CI 0.50 to 1.05; I-2 = 0%; seven trials; 729 participants). The effect of NPWT on occurrence of haematoma or skin blisters is uncertain (very low-certainty evidence); for haematoma, the RR was 0.67 (95% CI 0.28 to 1.59; I-2 = 0%; nine trials; 1202 participants) and for blisters the RR was 2.64 (95% CI 0.65 to 10.68; I-2 = 69%; seven trials; 796 participants). The overall effect of NPWT on pain is uncertain (very low-certainty evidence from seven trials (2218 participants) which reported disparate measures of pain); but moderate-certainty evidence suggests there is probably little difference between the groups in pain after three or six months following surgery for lower limb fracture (one trial, 1549 participants). There is also moderate-certainty evidence for women undergoing caesarean sections (one trial, 876 participants) and people having surgery for lower limb fractures (one trial, 1549 participants) that there is probably little difference in quality of life scores at 30 days or 3 or 6 months, respectively.
   Cost-effectiveness
   Five economic studies, based wholly or partially on trials included in our review, assessed the cost-effectiveness of NPWT compared with standard care. They considered NPWT in four indications: caesarean sections in obese women; surgery for lower limb fracture; knee/hip arthroplasty and coronary artery bypass graft surgery. They calculated quality-adjusted life-years for treatment groups and produced estimates of the treatments' relative cost-effectiveness. The reporting quality was good but the grade of the evidence varied from moderate to very low. There is moderate-certainty evidence that NPWT in surgery for lower limb fracture was not cost-effective at any threshold of willingness-to-pay and that NPWT is probably cost-effective in obese women undergoing caesarean section. Other studies found low or very low-certainty evidence indicating that NPWT may be cost-effective for the indications assessed.
   Authors' conclusions
   People experiencing primary wound closure of their surgical wound and treated prophylactically with NPWT following surgery probably experience fewer SSI than people treated with standard dressings (moderate-certainty evidence). There is no clear difference in number of deaths or wound dehiscence between people treated with NPWT and standard dressings (low-certainty evidence). There are also no clear differences in secondary outcomes where all evidence was low or very low-certainty. In caesarean section in obese women and surgery for lower limb fracture, there is probably little difference in quality of life scores (moderate-certainty evidence). Most evidence on pain is very low-certainty, but there is probably no difference in pain between NPWT and standard dressings after surgery for lower limb fracture (moderate-certainty evidence). Assessments of cost-effectiveness of NPWT produced differing results in different indications. There is a large number of ongoing studies, the results of which may change the findings of this review. Decisions about use of NPWT should take into account surgical indication and setting and consider evidence for all outcomes.
C1 [Norman, Gill; Dumville, Jo C.; Shi, Chunhu] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Goh, En Lin] Oxford Trauma, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Liu, Zhenmi] Sichuan Univ, West China Sch Publ Hlth, Chengdu, Peoples R China.
   [Liu, Zhenmi] Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China.
   [Chiverton, Laura] Great Ormond St Hosp Sick Children, NIHR Clin Res Facil, London, England.
   [Stankiewicz, Monica] Community & Oral Hlth Directorate, Chermside Community Hlth Ctr, Brisbane, Qld, Australia.
   [Reid, Adam] Fac Biol Med & Hlth, Sch Biol Sci, Manchester, Lancs, England.
C3 University of Manchester; Sichuan University; Sichuan University;
   University of London; University College London; Great Ormond Street
   Hospital for Children NHS Foundation Trust; University of Manchester
RP Norman, G (通讯作者)，Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
EM gill.norman@manchester.ac.uk
RI Norman, Gill/O-7029-2014; Liu, Zhenmi/O-7046-2014; Dumville,
   Jo/O-7867-2014; Reid, Adam/G-4460-2014; Goh, En Lin/I-7020-2019
OI Dumville, Jo/0000-0002-6546-3685; Reid, Adam/0000-0003-1752-3302; Goh,
   En Lin/0000-0002-0331-1803; Shi, Chunhu/0000-0003-0151-0451
FU National Health and Medical Research Council (NHMRC); National Institute
   for Health Research [13/89/08] Funding Source: researchfish
FX The authors would like to thank peer referees Nuala Livingstone and Ian
   Chetter who provided feedback on this update, and also Dirk Ubbink, Gill
   Worthy,Fausto Biancari, Susanne CunliHe, Patricia Davies, Ian Schemilt,
   Liz McInnes and another referee who wished to remain anonymous, who
   provided feedback on previous versions of this review. They would also
   like to thank copy editors Jenny Bellorini, Elizabeth Royle and Lisa
   Winer for their contribution to previous versions of this review, and
   Anne Lethaby for copy editing this version of the review. We continue to
   be grateful to Joan Webster, Wendy Chaboyer and Karen SherriH who were
   authors on previous versions of this review. We are especially grateful
   to Paul ScuHham who was also an author on previous versions of this
   review and has assisted with the interpretation of the economic evidence
   and provided comments on the review draL in this version. We are also
   grateful to the following people for their assistance with this update:
   Louise Hussey for assistance with screening and classification of
   ongoing studies; Jennifer Brown for assistance in screening of German
   language studies; Emma Connaughton for assistance with the plain
   language summary. The National Health and Medical Research Council
   (NHMRC) provided funding for this review from its Centre of Research
   Excellence scheme, which funds one or more of the authors.
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NR 200
TC 136
Z9 159
U1 2
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2020
IS 6
AR CD009261
DI 10.1002/14651858.CD009261.pub6
PG 263
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ME7WM
UT WOS:000544865300021
PM 32542647
DA 2026-07-24
ER

PT J
AU Hua, HT
   Zhang, L
   Guo, ZR
   Zhong, WL
   Chen, JF
   Wang, SL
   Guo, JG
   Wang, XW
AF Hua, Haotian
   Zhang, Lei
   Guo, Zairan
   Zhong, Wenlong
   Chen, Jiangfei
   Wang, Shilin
   Guo, Jiangang
   Wang, Xinwei
TI Antibiotic artificial bone implantation and external fixation for the
   treatment of infection after intramedullary nail fixation: a
   retrospective study of 33 cases
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Antibiotic artificial bone; External fixation; Intramedullary nail;
   Infection
ID LOADED CALCIUM-SULFATE; CHRONIC OSTEOMYELITIS; TIBIA
AB Objective: To explore the clinical effect of antibiotic artificial bone implantation and external fixation in the treatment of infection after intramedullary nail fixation.
   Methods: We retrospectively reviewed the clinical data of patients with infection after intramedullary nail fixation treated from March 2010 to August 2020. There were 27 males and 6 female, aged from 12 to 67 years (average 42.27 years), 18 cases on the left side and 15 cases on the right side. Among them, 20 cases were open fractures with initial injury and 13 cases were closed fractures. All patients were treated with intramedullary nail removal, local debridement, antibiotic artificial bone implantation and external fixation. Because of bone defects, 19 patients underwent secondary autologous cancellous bone grafting after infection control. Postoperative wound healing, related inflammatory indicators, fixation time, and bone healing time were recorded and followed up.
   Results: The 33 patients were followed up with period of 10-98 months (average 62.7 months). One patients failed to control the infection effectively after treatment, so received antibiotics artificial bone implantation again. Two patients also received antibiotic artificial bone implants again due to the recurrence of the infection. After treatment, infection was controlled and the fracture healed well. One patient received vacuum sealing drainage (VSD) due to persistent postoperative exudation, and five patients were also cured successfully after continuous dressing. Two patients had sinus tract after surgery, and the wound was cured by continuous dressing change. Nineteen patients received autogenous iliac bone grafts for healing due to bone defects ranging from 3 to 6.5 cm (average 4.15 cm) after infection control. The external fixation time of 33 patients ranged from 4 to 16 months (average 7.79 months), the bone healing time ranged from 4 to 13 months (average 6.67 months), and the related inflammatory indexes returned to normal within 2-8 weeks (average 4.48 weeks).
   Conclusion: Antibiotic artificial bone implantation and external fixation is an effective method for the treatment of infection after intramedullary nail fixation.
C1 [Hua, Haotian; Zhang, Lei; Guo, Zairan; Zhong, Wenlong; Chen, Jiangfei; Guo, Jiangang; Wang, Xinwei] Henan Prov Orthoped Hosp, Luoyang Orthoped Traumatol Hosp Henan Prov, Res & Treatment Ctr Bone & Joint Infect, Luoyang, Peoples R China.
   [Hua, Haotian; Wang, Shilin] Henan Univ Tradit Chinese Med, Zhengzhou, Peoples R China.
C3 Henan University of Traditional Chinese Medicine
RP Wang, XW (通讯作者)，Henan Prov Orthoped Hosp, Luoyang Orthoped Traumatol Hosp Henan Prov, Res & Treatment Ctr Bone & Joint Infect, Luoyang, Peoples R China.
EM lywxw188@163.com
FU Henan science and technology project [172102310414]
FX This study was supported by the Henan science and technology project
   (No. 172102310414).
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NR 30
TC 3
Z9 4
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD MAR 5
PY 2022
VL 23
IS 1
AR 209
DI 10.1186/s12891-022-05161-8
PG 8
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA ZN4DV
UT WOS:000764987800004
PM 35247995
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zhao, ZW
   Ma, DJ
   Xu, Y
   Guo, C
   Li, SQ
   Wang, J
   Wang, M
   Qin, YZ
   Liu, HS
AF Zhao, Zhewei
   Ma, Dongjie
   Xu, Yuan
   Guo, Chao
   Li, Shanqing
   Wang, Jian
   Wang, Mu
   Qin, Yingzhi
   Liu, Hongsheng
TI Surgical therapy and outcome of descending necrotizing mediastinitis in
   Chinese: a single-center series
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE descending necrotizing mediastinitis; video-assisted thoracic surgery;
   transcervical drainage; transthoracic drainage; surgical treatment
ID MANAGEMENT; STATEMENT
AB BackgroundDescending Necrotizing Mediastinitis (DNM) is an acute and often fatal infection that affects the neck and mediastinum. DNM treatment consists of broad-spectrum antibiotics, early diagnosis, and surgical debridement with multidisciplinary cooperation. However, owing to the rarity and complexity of this disease, the mortality rate is high. This retrospective study analyzed a single-center experience of managing DNM in Chinese patients over the last 10 years.MethodsA single-center, retrospective, observational, and descriptive study was conducted on 31 patients with DNM at Peking Union Medical College Hospital from 2012 to 2022. Case report forms were used to collect data which were then analyzed with a focus on surgical management and outcomes.ResultsThis study examined the outcomes of 31 patients diagnosed with DNM at our hospital. The most common comorbidities on admission were hypertension (48%) and diabetes mellitus (42%). The degree of diffusion of DNM according to Endo's classification was classified as follows: type I in 7 patients (22.6%), type IIA in 5 (16.1%), and type IIB in 19 patients (61.3%). Among these patients, 13 (41.9%) were found to have a single microbial infection, while 16 (51.6%) were found to have polymicrobial infections. In all cases, neck drainage was performed via cervicotomy, with multiple drains (64.5%) and vacuum sealing drainage (VSD) (35.5%). Mediastinal drainage was performed via a cervical mediastinotomy (51.6%), video-assisted thoracic surgery (VATS) (41.9%), or thoracotomy (6.5%). The 30-day mortality rate was 25.8% and 24.0 days of the average length of hospital stay.ConclusionEarly accurate diagnosis and timely intervention have been shown to be correlated with a positive prognosis. Cervicothoracic CT (computed tomography) is essential for the diagnosis, staging, and evaluation of the optimal surgical treatment. Cervicotomy and video-assisted thoracoscopic surgery with percutaneous drainage is effective, even in advanced cases. Additionally, the application of VSD in cervical incision did not improve prognosis but may shorten the length of ICU (intensive care unit) and hospital stays.
C1 [Zhao, Zhewei; Ma, Dongjie; Xu, Yuan; Guo, Chao; Li, Shanqing; Qin, Yingzhi; Liu, Hongsheng] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Thorac Surg, Beijing, Peoples R China.
   [Wang, Jian] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept ENT, Beijing, Peoples R China.
   [Wang, Mu] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Qin, YZ; Liu, HS (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Thorac Surg, Beijing, Peoples R China.
EM qinyzh@pumch.cn; hongshengliu16@163.com
RI Guo, Chao/PTE-6398-2026
OI Wang, Mu/0000-0003-1777-2309
FU National Natural Science Foundation of China [82102745]; National High
   Level Hospital Clinical Research Funding [2022-PUMCH-A-187,
   2022-PUMCH-B-012]; CAMS Innovation Fund for Medical Sciences (CIFMS)
   [2022 I2M CT B 002]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the National Natural Science Foundation of China (No. 82102745), the
   National High Level Hospital Clinical Research Funding (Nos.
   2022-PUMCH-A-187 and 2022-PUMCH-B-012), and the CAMS Innovation Fund for
   Medical Sciences (CIFMS) (No. 2022 I2M C&T B 002).
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NR 32
TC 9
Z9 12
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JAN 11
PY 2024
VL 10
AR 1337852
DI 10.3389/fmed.2023.1337852
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FU1S5
UT WOS:001148283600001
PM 38274461
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jin, CH
   Tian, ZH
AF Jin, Changhui
   Tian, Zonghua
TI Psychological stress level surveys in patients with diabetic foot ulcers
   and the application effect of using loofah sponges during VSD treatment
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Diabetic foot ulcer; psychological stress; loofah fiber; VSD treatment;
   nursing interventions
ID PRESSURE WOUND THERAPY
AB Objective: To investigate the psychological stress levels in patients with diabetic foot ulcer (DFU) and evaluate the effects of using a luffa sponge in vacuum sealing drainage (VSD) treatment. Methods: This retrospective study analyzed the clinical data from 110 DFU patients treated with VSD at The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University) between September 2021 and October 2023. Patients were categorized into two groups based on psychological stress levels: an observation group (with psychological stress, n=42) and a control group (without psychological stress, n=68). Baseline data were analyzed to identify factors influencing psychological stress. The observation group was further divided into the conventional care group and the loofah fiber care group, each with 21 patients, to evaluate the effect of using a loofah sponge during VSD treatment. Results: Logistic regression analysis identified Wagner classification and diabetes-related distress levels as significant factors influencing psychological stress (P<0.05). Post-intervention, the loofah fiber care group showed significantly lower scores on HQ-9, GAD-7, and SRSS (all P<0.05). Additionally, the loofah fiber care group showed lower frequencies of ASD dressing changes, shorter wound healingtimes, shorter hospital stays, and lower VAS pain scores (all P<0.05). Quality of life scores were significantly higher in the loofah fiber care group across all dimensions (P<0.05), and DASS-21 scores were significantly lower post-intervention (P<0.05). The loofah fiber care group also demonstrated significantly better outcomes in Wagner classification and diabetes-related distress levels, with higher patient satisfaction (all P<0.05). Conclusion: This study highlights significant factors influencing psychological stress in patients with DFU and demonstrates that loofah fiber nursing interventions during VSD treatment improve psychological stress, wound healing, and quality of life. This method provides a promising approach to enhance patient outcomes and satisfaction.
C1 [Jin, Changhui] Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Operat Room, Zunyi 563000, Guizhou, Peoples R China.
   [Tian, Zonghua] Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Burn Plast Surg, 98 Fenghuang North Rd, Zunyi 563000, Guizhou, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University
RP Tian, ZH (通讯作者)，Zunyi Med Univ, Peoples Hosp Zunyi 1, Affiliated Hosp 3, Burn Plast Surg, 98 Fenghuang North Rd, Zunyi 563000, Guizhou, Peoples R China.
EM tzh18685283928@163.com
FU Natural Science Foundation of Zunyi Science and Technology Department
   [Zunyi Kehe HZ Zi (2019) 158Hao]
FX This work was supported by the Natural Science Foundation of Zunyi
   Science and Technology Department (Zunyi Kehe HZ Zi (2019) 158Hao) .
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NR 28
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 12
BP 8032
EP 8042
DI 10.62347/LCRY8746
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA R8S6G
UT WOS:001394079800005
PM 39822498
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Xu, ZB
   Dai, GG
   Sun, ZY
   Li, H
   Yan, J
   Li, HQ
   Guo, ZQ
AF Xu, Zhong-Bao
   Dai, Guo-Guang
   Sun, Zhong-Ye
   Li, Hao
   Yan, Jun
   Li, Hai-Qing
   Guo, Zhao-Qi
TI Application of antibiotic bone cement combined with lobulated perforator
   flap based on descending branch of the lateral circumflex femoral artery
   in treatment of infected traumatic tissue defects of foot
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Perforator flap; Anterolateral thigh flap; Bone cement; Enhanced
   recovery after surgery
ID ANTEROLATERAL THIGH FLAP; FASCIOCUTANEOUS FREE FLAPS; VACUUM SEALING
   DRAINAGE; SOFT-TISSUE; VASCULAR ANATOMY; RECONSTRUCTION; OSTEOMYELITIS;
   MANAGEMENT; SKIN; DIAGNOSIS
AB ObjectiveTo evaluate the clinical effectiveness of antibiotic bone cement combined with the lobulated perforator flap based on the descending branch of the lateral circumflex femoral artery (d-LCFA) in the treatment of infected traumatic tissue defects in the foot, in accordance with the Enhanced Recovery after Surgery (ERAS) concept.MethodsFrom December 2019 to November 2022, 10 patients with infected traumatic tissue defects of the foot were treated with antibiotic bone cement combined with the d-LCFA lobulated perforator flap. The cohort comprised 6 males and 4 females, aged 21 to 67 years. Initial infection control was achieved through debridement and coverage with antibiotic bone cement, requiring one debridement in nine cases and two debridements in one case. Following infection control, the tissue defects were reconstructed utilizing the d-LCFA lobulated perforator flap, with the donor site closed primarily. The flap area ranged from 12 cmx6 cm to 31 cmx7 cm. Postoperative follow-up included evaluation of flap survival, donor site healing, and ambulatory function of the foot.ResultsThe follow-up period ranged from 7 to 24 months, averaging 14 months. Infection control was achieved successfully in all cases. The flaps exhibited excellent survival rates and the donor site healed by first intention. Based on the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale, pain and function were evaluated as excellent in 3 cases, good in 5 cases, and moderate in 2 cases.ConclusionThe application of antibiotic bone cement combined with the d-LCFA lobulated perforator flap is an effective treatment for infected traumatic tissue defects of the foot with the advantages of simplicity, high repeatability, and precise curative effects. The application of the d-LCFA lobulated perforator flap in wound repair causes minimal damage to the donor site, shortens hospital stays, lowers medical expenses, and accelerates patient rehabilitation, aligning with the ERAS concept. Therefore, it is a practice worth promoting in clinical use.
C1 [Xu, Zhong-Bao; Dai, Guo-Guang; Sun, Zhong-Ye; Li, Hao; Yan, Jun; Li, Hai-Qing; Guo, Zhao-Qi] Liaocheng Peoples Hosp, Dept Orthopaed, 67 Dongchang St, Liaocheng 252000, Shandong, Peoples R China.
RP Dai, GG (通讯作者)，Liaocheng Peoples Hosp, Dept Orthopaed, 67 Dongchang St, Liaocheng 252000, Shandong, Peoples R China.
EM daiguoguang@126.com
RI li, haiqing/GYJ-4946-2022; Xu, ZhongBao/LDG-0483-2024; dai,
   guoguang/PGA-6389-2026
FU Natural Science Foundation of Shandong Province
FX Not applicable.
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NR 49
TC 2
Z9 4
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD AUG 27
PY 2024
VL 25
IS 1
AR 673
DI 10.1186/s12891-024-07810-6
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA E0M9T
UT WOS:001300045900005
PM 39192266
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shi, XF
   Lin, LX
   Sun, JY
AF Shi, Xiufang
   Lin, Lixin
   Sun, Jianying
TI The Value of Continuous Closed Negative Pressure Drainage Combined with
   Antibacterial Biofilm Dressing in Postoperative Wound Healing for Severe
   Pancreatitis
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
AB Objective To investigate the application value of continuous vacuum sealing drainage (VSD) combined with antibacterial biofilm hydraulic fiber dressing in wound healing after surgery for severe acute pancreatitis (SAP).
   Methods A total of 82 SAP patients who underwent minimally invasive surgery in our hospital from March 2021 to September 2022 were randomly divided into two groups using a random number table method. Each group consisted of 41 cases. Both groups received surgical treatment, with the control group receiving VSD treatment and the observation group receiving VSD treatment combined with antibacterial biofilm hydraulic fiber dressing. The postoperative recovery efficiency, preoperative and postoperative wound area reduction rate, pressure ulcer healing score (PUSH), serum biological indicators (white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT)), and the rate of wound-related adverse reactions were compared between the two groups.
   Results There was no statistical difference between the two groups in the time to resume eating (P >.05). However, the wound healing time and hospitalization days in the observation group were significantly shorter than those in the control group (P <.05). After 7 and 14 days of treatment, the wound area reduction rate in the observation group was significantly higher than in the control group, and the PUSH score was significantly lower than in the control group (P <.05). WBC, CRP, and PCT levels in the observation group were lower than in the control group (P <.05). The incidence of wound-related adverse reactions in the observation group (12.20%) was significantly lower than that in the control group (34.15%) (P <.05).
   Conclusions The application of VSD combined with antibacterial biofilm hydraulic fiber dressing in the postoperative wound healing of SAP has a significant effect. It improves wound healing efficiency, reduces pressure ulcer scores, decreases inflammation indicators, and lowers the incidence of adverse reactions. While further research is needed to determine its impact on infection and inflammation prevention, this treatment approach shows promise for clinical application.
C1 [Shi, Xiufang; Lin, Lixin; Sun, Jianying] Yantai Yuhuangding Hosp, Yantai, Peoples R China.
RP Sun, JY (通讯作者)，Yantai Yuhuangding Hosp, Yantai, Peoples R China.
EM jianying_sun10@163.com
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NR 15
TC 8
Z9 8
U1 0
U2 5
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JUL-AUG
PY 2023
VL 29
IS 5
BP 375
EP 379
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA M2TQ1
UT WOS:001028759700057
PM 37235500
DA 2026-07-24
ER

PT J
AU Lin, ZJ
   Chen, ZJ
   Hu, YC
   Weng, DY
   Huang, JF
   Lin, DN
   Lin, DY
AF Lin, Zhengjie
   Chen, Zhijing
   Hu, Yangcheng
   Weng, Danyi
   Huang, Jianfeng
   Lin, Dane
   Lin, Danyi
TI Integrated Management of Mycobacterium abscessus Infections Following
   Aesthetic Fat Grafting: A Promising Combination of Targeted Medication
   and Minimally Invasive Surgery
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article; Early Access
DE Autologous fat filling; Mycobacterium abscessus; Infected wound; Anti-TB
   drugs
ID DIAGNOSIS; SKIN
AB BackgroundInfections caused by nontuberculous mycobacteria (NTM), particularly Mycobacterium abscessus, represent rare but increasingly reported complications following cosmetic fat transplantation. However, standardized and effective treatment protocols remain underexplored. This study aimed to evaluate the efficacy of anti-tuberculosis (anti-TB) medication combined with local vacuum aspiration in treating multiple wound infections caused by Mycobacterium abscessus complex following autologous fat transplantation.MethodsBetween June 2017 and June 2019, 10 patients with M. abscessus complex infection after autologous fat grafting were enrolled, involving a total of 70 infected wounds (31 facial, 32 breast, and 7 thigh sites). Prior to minimal-incision open debridement, ultrasound localization was performed. Necrotic granulation tissue was thoroughly curetted, followed by vacuum sealing drainage (VSD) with continuous aspiration. Irrigation and drainage tubes were subsequently placed to promote granulation tissue formation. All patients received standardized anti-TB drug therapy.ResultsDuring a follow-up period ranging from 8 to 16 months (mean: 12 months), all 70 wounds in the 10 enrolled patients achieved satisfactory healing in terms of both deep tissue repair and superficial appearance. No recurrence of infection was observed throughout the follow-up period. Wound closure was accomplished without the need for additional surgical reconstruction in all cases. The combination of anti-TB chemotherapy and vacuum aspiration consistently promoted granulation tissue formation and controlled local inflammation, leading to functionally and cosmetically acceptable outcomes across all anatomical sites, including face, breast, and thigh regions.ConclusionThe combination of minimal-incision debridement, local vacuum aspiration, and anti-TB medication provides an effective and practical treatment for M. abscessus infections secondary to autologous fat grafting. This integrated approach is recommended for managing such challenging postoperative infections.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
C1 [Lin, Zhengjie; Lin, Danyi] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pathol, Guangzhou 510080, Peoples R China.
   [Lin, Zhengjie] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Endocrinol & Metab, Hengyang 421001, Peoples R China.
   [Chen, Zhijing] Shantou Univ, Affiliated Hosp 1, Dept Med Cosmet Ctr, Med Coll, Shantou 515041, Peoples R China.
   [Hu, Yangcheng] Shantou Cent Hosp, Dept Urol, Shantou 515031, Peoples R China.
   [Weng, Danyi] Shantou Chaonan Minsheng Hosp, Dept Nephrol, Shantou 515144, Peoples R China.
   [Huang, Jianfeng] Shantou Univ, Affiliated Hosp 1, Dept Pediat, Med Coll, Shantou 515041, Peoples R China.
   [Lin, Dane] Shantou Univ, Affiliated Hosp 1, Dept Neonatal Intens Care Unit, Dept Pediat,Med Coll, Shantou 515041, Peoples R China.
C3 Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital; University of South China;
   Shantou University; Shantou University; Shantou University
RP Lin, DY (通讯作者)，Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pathol, Guangzhou 510080, Peoples R China.; Huang, JF (通讯作者)，Shantou Univ, Affiliated Hosp 1, Dept Pediat, Med Coll, Shantou 515041, Peoples R China.; Lin, DN (通讯作者)，Shantou Univ, Affiliated Hosp 1, Dept Neonatal Intens Care Unit, Dept Pediat,Med Coll, Shantou 515041, Peoples R China.
EM 1076101404@qq.com; m13715870419@163.com; danyi_l@126.com
FU Guangdong Provincial Administration of Traditional Chinese Medicine
   Project [20251008]
FX This study was supported by Guangdong Provincial Administration of
   Traditional Chinese Medicine Project (No.20251008).
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD 2026 JUN 15
PY 2026
DI 10.1007/s00266-026-05961-6
EA JUN 2026
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JN1SP
UT WOS:001793294600001
PM 42298160
DA 2026-07-24
ER

PT J
AU Hardin, MO
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AF Hardin, Mark O.
   Mace, James E.
   Ritchie, John D.
   Chung, Kevin K.
   Markell, Katharine W.
   Renz, Evan M.
   Wolf, Steven E.
   Blackbourne, Lorne H.
   White, Christopher E.
TI An Experience in the Management of the Open Abdomen in Severely Injured
   Burn Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT 41st Annual Meeting of the American-Burn-Association
CY MAR 24-27, 2009
CL San Antonio, TX
SP Amer Burn Assoc
ID ABDOMINAL COMPARTMENT SYNDROME; OPERATION IRAQI FREEDOM; FASCIAL
   CLOSURE; TRAUMA PATIENTS
AB Few descriptions of temporary abdominal closure for planned relaparotomy have been reported in burned patients. The purpose of this study is to describe our experience and outcomes in the management of burned patients with an open abdomen. The authors performed a retrospective review of all admissions to our burn center from March 2003 to June 2008, identifying patients treated by laparotomy with temporary abdominal closure. The authors collected data on patient demographics, indication for laparotomy, methods of temporary and definitive abdominal closure, and outcomes. Of 2,104 patients admitted, 38 underwent a laparotomy with temporary abdominal closure. Their median TBSA was 55%, and the incidence of inhalation injury was 58%. Abdominal compartment syndrome was the most common indication for laparotomy (82%) followed by abdominal trauma (16%). The in-hospital mortality associated with an open abdomen was 68%. Temporary abdominal closure was performed most commonly using negative pressure wound therapy (90%). Fascial closure was performed in 21 patients but was associated with a 38% rate of failure requiring reexploration. Of 12 survivors, fascial closure was achieved in seven patients and five were managed with a planned ventral hernia. Burned patients who necessitate an open abdomen management strategy have a high morbidity and mortality. Fascial closure was associated with a high rate of failure but was successful in a select group of patients. Definitive abdominal closure with a planned ventral hernia was associated with no increased mortality and remains an option when "tension-free" fascial closure cannot be achieved. (J Burn Care Res 2012;33:491-496)
C1 [Hardin, Mark O.; Mace, James E.; Ritchie, John D.; Chung, Kevin K.; Markell, Katharine W.; Renz, Evan M.; Wolf, Steven E.; Blackbourne, Lorne H.; White, Christopher E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP White, CE (通讯作者)，USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
OI Wolf, Steven/0000-0003-2972-3440
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NR 21
TC 12
Z9 14
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2012
VL 33
IS 4
BP 491
EP 496
DI 10.1097/BCR.0b013e3182479b00
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 972KC
UT WOS:000306275000016
PM 22777397
DA 2026-07-24
ER

PT J
AU Vana, LPM
   Battlehner, CN
   Ferreira, MA
   Caldini, EG
   Gemperli, R
   Alonso, N
AF Molina Vana, Luiz Philipe
   Battlehner, Claudia Naves
   Ferreira, Marcelo Alves
   Caldini, Elia Garcia
   Gemperli, Rolf
   Alonso, Nivaldo
TI Comparative long-term study between two dermal regeneration templates
   for the reconstruction of burn scar contractures in humans: Clinical and
   histological results
SO BURNS
LA English
DT Article
DE Negative-pressure wound therapy; Dermal regeneration template;
   Artificial skin; Integra; Matriderm
ID NEGATIVE-PRESSURE THERAPY; INTEGRA ARTIFICIAL SKIN; INTERRATER
   RELIABILITY; WOUND THERAPY; THICKNESS; SUBSTITUTES; DEFECTS; SURGERY;
   PATIENT; DESIGN
AB The advent of dermal regeneration templates has fostered major advances in the treatment of acute bums and their sequelae, in the last three decades. Both data on morphological aspects of the newly-formed tissue, and clinical trials comparing different templates, are few. The goal of this study was to prospectively analyze the outcome of randomized patients treated with two of the existing templates, followed by thin skin autograft. They are both 2mm-thick bovine collagen templates (Matriderm (R) and Integra (R)), the latter includes a superficial silicone layer. Surgery was performed on patients with impaired mobility resulting from bum sequelae (n =12 per template) in a two-step procedure. Negative pressure therapy was applied after surgery; patients were monitored for 12 months. No infra or postoperative complications were observed. Data on scar skin quality (Vancouver scar scale), rate of mobility recovery, and graft contraction were recorded; as well as morphological analyses at light microscopical level. Improvement in mobility and skin quality were demonstrated along with graft contraction, in all patients. The double layer template showed the best performance in retraction rate, skin quality and mobility recovery. The subepidermal newly-formed connective tissue showed no histoarchitectural differences between the templates. The double layer template was not absorbed up to 12 months after placement. (C) 2019 Elsevier Ltd and ISBI. All rights reserved.
C1 [Molina Vana, Luiz Philipe; Gemperli, Rolf; Alonso, Nivaldo] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, Brazil.
   [Molina Vana, Luiz Philipe; Gemperli, Rolf; Alonso, Nivaldo] Div Cirurgia Plast & Queimaduras, Sao Paulo, Brazil.
   [Battlehner, Claudia Naves; Ferreira, Marcelo Alves; Caldini, Elia Garcia] Univ Sao Paulo, Fac Med FMUSP, Dept Patol, Sao Paulo, Brazil.
   [Battlehner, Claudia Naves; Ferreira, Marcelo Alves; Caldini, Elia Garcia] Lab Biol Celular, Dept Patol, LIM59, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Vana, LPM (通讯作者)，Rua Batataes 460 Cj11, BR-01423010 Sao Paulo, Brazil.
EM philipe@uol.com.br
RI ; Caldini, Elia Garcia/F-1105-2011; alonso, nivaldo/AAB-4570-2021;
   Ferreira, Marcelo/AAC-4009-2022; Gemperli, Rolf/C-9116-2012
OI Vana, Luiz Philipe/0000-0002-7305-8399; Caldini, Elia
   Garcia/0000-0001-5322-3812; alonso, nivaldo/0000-0003-1532-9610;
   Ferreira, Marcelo/0000-0003-4181-760X; 
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NR 59
TC 28
Z9 35
U1 2
U2 13
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2020
VL 46
IS 3
BP 596
EP 608
DI 10.1016/j.burns.2019.09.005
PG 13
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA LK2RF
UT WOS:000530707800012
PM 31645293
DA 2026-07-24
ER

PT J
AU Yoshida, S
   Koshima, I
   Hamada, Y
   Sasaki, A
   Fujioka, Y
   Nagamatsu, S
   Yokota, K
   Harima, M
   Yamashita, S
AF Yoshida, Shuhei
   Koshima, Isao
   Hamada, Yuichi
   Sasaki, Ayano
   Fujioka, Yumio
   Nagamatsu, Shogo
   Yokota, Kazunori
   Harima, Mitsunobu
   Yamashita, Shuji
TI Lymphovenous Anastomosis Aids Wound Healing in Lymphedema: Relationship
   Between Lymphedema and Delayed Wound Healing from a View of Immune
   Mechanisms
SO ADVANCES IN WOUND CARE
LA English
DT Editorial Material
DE lymphedema; wound healing; immunology; lymphovenous anastomosis; chronic
   inflammation; immunodeficiency
AB Delayed wound healing in lymphedema is assumed to be caused by two reasons, pathophysiological and immunological effects of lymphedema. The aim of this review is to establish how impaired lymphatics alter wound healing pathophysiologically and immunologically, and to propose treatment modalities that can promote wound healing in lymphedema. Lymphaticovenular anastomoses (lymphovenous anastomoses [LVAs]) were performed on patients who had recurrent cellulitis several times with lymphorrhea and developed severe ulcers that were refractory to skin grafts, flaps, and conservative therapy. The lymphorrhea and the ulcer had healed by 4 weeks. Moreover, the lymphedema improved without compression therapy. Lymphedema is characterized pathophysiologically by localized peripheral edema that compresses the microvasculature and lymphatic vasculature and impairs tissue remodeling. Another suspected mechanism is an imbalance in the differentiation of participating immune cells. Profound suppression of T helper (Th)1 cells is likely to increase the risk of infection, and excessive differentiation of Th2 cells, including M2 macrophage polarization, may promote fibrosis, which disrupts the carefully orchestrated wound healing process. Although negative-pressure wound therapy is useful for the treatment of delayed wound healing in lymphedema, LVAs may be necessary to treat the fundamental problem of lymphedema. LVAs are considered to create a bypass to the lymph nodes through which dendritic cells (DCs) can transmit antigen information to T cells. LVAs are considered to neutralize chronic inflammation by allowing more DCs to return into the circulation, thereby improving wound healing.
C1 [Yoshida, Shuhei; Koshima, Isao] Hiroshima Univ Hosp, Int Ctr Lymphedema, Hiroshima, Japan.
   [Hamada, Yuichi] Japanese Red Cross Fukuoka Hosp, Plast & Reconstruct Surg, Fukuoka, Fukuoka, Japan.
   [Sasaki, Ayano; Fujioka, Yumio; Nagamatsu, Shogo; Yokota, Kazunori] Hiroshima Univ, Plast & Reconstruct Surg, Hiroshima, Japan.
   [Harima, Mitsunobu; Yamashita, Shuji] Univ Tokyo, Plast & Reconstruct Surg, Tokyo, Japan.
C3 Hiroshima University; Hiroshima University; University of Tokyo
RP Yoshida, S (通讯作者)，Hiroshima Univ Hosp, Int Ctr Lymphedema, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM syuheiyoshida44@gmail.com
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NR 17
TC 33
Z9 37
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN
PY 2019
VL 8
IS 6
BP 263
EP 269
DI 10.1089/wound.2018.0871
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IL1VR
UT WOS:000477090900005
PM 31832276
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Rai, V
   Le, H
   Agrawal, DK
AF Rai, Vikrant
   Le, Hoangvi
   Agrawal, Devendra K.
TI Novel mediators regulating angiogenesis in diabetic foot ulcer healing
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE amputation; angiogenesis; anti-angiogenic mediators; diabetes; diabetic
   foot ulcer; nonhealing ulcer; proangiogenic mediators
ID ENDOTHELIAL GROWTH-FACTOR; FRIZZLED-RELATED PROTEIN; HIGH GLUCOSE; CELL
   MIGRATION; EXPRESSION; NEOVASCULARIZATION; INJURY; DIFFERENTIATION;
   ADRENOMEDULLIN; FIBRONECTIN
AB A non-healing diabetic foot ulcer (DFU) is a debilitating clinical problem amounting to socioeconomic and psychosocial burdens. DFUs increase morbidity due to prolonged treatment and mortality in the case of non-treatable ulcers resulting in gangrene and septicemia. The overall amputation rate of the lower extremity with DFU ranges from 3.34% to 42.83%. Wound debridement, antibiotics, applying growth factors, negative pressure wound therapy, hyperbaric oxygen therapy, topical oxygen, and skin grafts are common therapies for DFU. However, recurrence and nonhealing ulcers are still major issues. Chronicity of inflammation, hypoxic environment, poor angiogenesis, and decreased formation of the extracellular matrix (ECM) are common impediments leading to nonhealing patterns of DFUs. Angiogenesis is crucial for wound healing since proper vessel formation facilitates nutrients, oxygen, and immune cells to the ulcer tissue to help in clearing out debris and facilitate healing. However, poor angiogenesis due to decreased expression of angiogenic mediators and matrix formation results in nonhealing and ultimately amputation. Multiple proangiogenic mediators and vascular endothelial growth factor (VEGF) therapy exist to enhance angiogenesis, but the results are not satisfactory. Thus, there is a need to investigate novel pro-angiogenic mediators that can either alone or in combination enhance the angiogenesis and healing of DFUs. In this article, we critically reviewed the existing pro-angiogenic mediators followed by potentially novel factors that might play a regulatory role in promoting angiogenesis and wound healing in DFUs.
C1 [Rai, Vikrant; Le, Hoangvi; Agrawal, Devendra K.] Western Univ Hlth Sci, Dept Translat Res, Pomona, CA 91766 USA.
C3 Western University of Health Sciences
RP Agrawal, DK (通讯作者)，Western Univ Hlth Sci, Dept Translat Res, Pomona, CA 91766 USA.
EM DAgrawal@WesternU.edu
RI Agrawal, Devendra/GLR-3925-2022; Rai, Vikrant/J-3680-2019
OI Agrawal, Devendra/0000-0001-5445-0013; Rai, Vikrant/0000-0001-6286-2341
FU National Heart, Lung and Blood Institute, National Institutes of Health,
   USA [R01 HL144125, R01 HL147662]
FX This work was supported by research grants R01 HL144125 and R01 HL147662
   to DKA from the National Heart, Lung and Blood Institute, National
   Institutes of Health, USA.
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NR 110
TC 14
Z9 15
U1 4
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2023
VL 101
IS 10
BP 488
EP 501
DI 10.1139/cjpp-2023-0193
PG 14
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA U2VF4
UT WOS:001083423400001
PM 37459652
DA 2026-07-24
ER

PT J
AU Kadota, H
   Shimamoto, R
   Fukushima, S
   Inatomi, Y
   Ikemura, K
   Miyashita, K
   Kamizono, K
   Hanada, M
   Yoshida, S
AF Kadota, Hideki
   Shimamoto, Ryo
   Fukushima, Seita
   Inatomi, Yusuke
   Ikemura, Ko
   Miyashita, Kayo
   Kamizono, Kenichi
   Hanada, Masuo
   Yoshida, Sei
TI Lymphaticovenular anastomosis for lymph vessel injury in the pelvis and
   groin
SO MICROSURGERY
LA English
DT Article
AB Background Lymphatic diseases due to lymph vessel injuries in the pelvis and groin require immediate clinical attention when conventional treatments fail. We aimed to clarify the effectiveness of and indications for lymphaticovenular anastomosis (LVA) to treat these lymphatic diseases.
   Methods We retrospectively evaluated six patients who underwent LVA for lymphatic diseases due to lymph vessel injuries in the pelvis and groin. Specific pathologies included groin lymphorrhea (N = 3), chylous ascites (N = 2), and retroperitoneal lymphocele (N = 1). The maximum lymphatic fluid leakage volume was 150-2600 mL daily. Conventional treatments (compression, drainage, fasting, somatostatin administration, negative pressure wound therapy, or lymph vessel ligation) had failed to control leakage in all cases. We performed lower extremity LVAs after confirming the site of lymph vessel injury using lymphoscintigraphy. We preferentially placed LVAs in thigh sites that showed a linear pattern by indocyanine green lymphography. Postoperative lymphatic fluid leakage volume reduction was evaluated, and leakage cessation was recorded when the drainage volume approached 0 mL.
   Results LVA was performed at an average of 4.3 sites (range, 3-6 sites) in the thigh and 2.7 sites (range, 0-6 sites) in the lower leg. Lymphatic fluid leakage ceased in all cases after a mean of 6 days (range, 1-11 days) postoperatively. No recurrence of symptoms was observed during an average follow-up of 2.9 (range, 0.5-5.5) years.
   Conclusions LVA demonstrates excellent and rapid effects. We recommend lower extremity LVA for the treatment of lymphatic diseases due to lymph vessel injuries in the pelvis and groin.
C1 [Kadota, Hideki; Shimamoto, Ryo; Fukushima, Seita; Inatomi, Yusuke; Ikemura, Ko; Miyashita, Kayo; Kamizono, Kenichi; Hanada, Masuo; Yoshida, Sei] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Fukuoka, Japan.
C3 Kyushu University
RP Kadota, H (通讯作者)，Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM kadohide@qent.med.kyushu-u.ac.jp
RI Kadota, Hideki/AAU-7710-2020
OI Kadota, Hideki/0000-0001-7833-3524
CR Abai B, 2007, J VASC SURG, V45, P610, DOI 10.1016/j.jvs.2006.10.043
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NR 25
TC 15
Z9 16
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD JUL
PY 2021
VL 41
IS 5
BP 421
EP 429
DI 10.1002/micr.30741
EA APR 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TD8RQ
UT WOS:000636173000001
PM 33811397
DA 2026-07-24
ER

PT J
AU Bekeny, JC
   Huffman, SS
   Thomas, C
   Tumminello, M
   Kata, A
   Parikh, R
   Tom, LK
   Kleiber, GM
AF Bekeny, Jenna C.
   Huffman, Samuel S.
   Thomas, Chris
   Tumminello, Mariana
   Kata, Anna
   Parikh, Rajiv
   Tom, Laura K.
   Kleiber, Grant M.
TI Small Intestinal Perforation after 360-Degree Liposuction: A Case Report
SO AESTHETIC PLASTIC SURGERY
LA English
DT Article
DE Liposuction; Lipectomy; Intestinal perforation; Abdominal injuries;
   Complications
ID BOWEL PERFORATION; NECROTIZING FASCIITIS; ABDOMINAL LIPOSUCTION; SUCTION
   LIPOPLASTY; COMPLICATIONS; PERITONITIS; SURGERY; SAFETY
AB ObjectiveAs one of the most commonly performed cosmetic procedures, liposuction is relatively safe. Bowel injury following liposuction is a rare but devastating complication, which necessitates hospital admission and surgical intervention. The authors highlight a case report describing the presentation, diagnosis, and management of a patient with bowel injury following liposuction.CaseA 58-year-old woman presented with abdominal pain, erythema, and discharge three days after 360-degree abdominal liposuction with concomitant fat grafting to bilateral buttocks at an outpatient surgery center. Bowel perforation was suspected after CT-scan revealed extraluminal gas in the abdomen and communication that traversed the peritoneum. Exploratory laparotomy was performed which demonstrated at least one site of distinct perforation of the small bowel and an area omentum noted to be inflamed, thickened and with a purulent rind. The patient underwent 20-cm small bowel resection and partial omentectomy temporarily closed with negative pressure wound therapy. After subsequent abdominal wall debridements the patient received ventral hernia repair with bridging mesh and abdominal closure.ConclusionsWhile safe, elective cosmetic procedures are not without risk of serious and even fatal complications. Providers must be familiar with the presentation of bowel injury following abdominal liposuction to prevent delays in appropriate surgical and medical care.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
C1 [Bekeny, Jenna C.; Huffman, Samuel S.; Parikh, Rajiv; Tom, Laura K.; Kleiber, Grant M.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd, Washington, DC 20007 USA.
   [Huffman, Samuel S.; Thomas, Chris] Georgetown Univ, Sch Med, Washington, DC USA.
   [Tumminello, Mariana; Kata, Anna] MedStar Georgetown Univ Hosp, Dept Gen Surg, Washington, DC USA.
C3 Georgetown University; Georgetown University; Georgetown University
RP Kleiber, GM (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 3800 Reservoir Rd, Washington, DC 20007 USA.
EM grant.m.kleiber@medstar.net
RI Tom, Laura/OPN-7036-2025; Kleiber, Grant/IQV-6852-2023
OI Huffman, Samuel/0000-0002-1779-8384
CR Agha RA, 2018, INT J SURG, V60, P132, DOI 10.1016/j.ijsu.2018.10.028
   [Anonymous], 2020, Plastic surgery statistics report
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NR 26
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0364-216X
EI 1432-5241
J9 AESTHET PLAST SURG
JI Aesthet. Plast. Surg.
PD MAR
PY 2024
VL 48
IS 5
BP 946
EP 952
DI 10.1007/s00266-023-03567-w
EA AUG 2023
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MS1F8
UT WOS:001065125900004
PM 37653177
DA 2026-07-24
ER

PT J
AU Ferreira, MC
   de Carvalho, VF
   Kamamoto, F
   Tuma, P
   Paggiaro, AO
AF Ferreira, Marcus Castro
   de Carvalho, Viviane Fernandes
   Kamamoto, Fabio
   Tuma Junior, Paulo
   Paggiaro, Andre Oliveira
TI Negative pressure therapy (vacuum) for wound bed preparation among
   diabetic patients: case series
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Diabetic foot; Skin transplantation; Surgical flaps; Negative-pressure
   wound therapy; Wound healing
ID ASSISTED CLOSURE; RISK-FACTORS; FOOT ULCERS; PREVALENCE; MANAGEMENT;
   NEUROPATHY; LIMB
AB CONTEXT: Complications from diabetes mellitus affecting the lower limbs occur in 40 to 70% of such patients. Neuropathy is the main cause of ulceration and may be associated with vascular impairment. The wound evolves with necrosis and infection, and if not properly treated, amputation may be the end result. Surgical treatment is preferred in complex wounds without spontaneous healing. After debridement of the necrotic tissue, the wound bed needs to be prepared to receive a transplant of either a graft or a flap. Dressings can be used to prepare the wound bed, but this usually leads to longer duration of hospitalization. Negative pressure using a vacuum system has been proposed for speeding up the treatment. This paper had the objective of analyzing the effects of this therapy on wound bed preparation among diabetic patients.
   CASE SERIES: Eighty-four diabetic patients with wounds in their lower limbs were studied. A commercially available vacuum system was used for all patients after adequate debridement of necrotic tissues. For 65 patients, skin grafts completed the treatment and for the other 19, skin flaps were used. Wound bed preparation was achieved over an average time of 7.51 days for 65 patients and 10 days for 12 patients, and in only one case was not achieved.
   CONCLUSIONS: This experience suggests that negative pressure therapy may have an important role in wound bed preparation and as part of the treatment for wounds in the lower limbs of diabetic patients.
C1 [Ferreira, Marcus Castro; Paggiaro, Andre Oliveira] Univ Sao Paulo, Fac Med, Div Plast Surg, Sao Paulo, Brazil.
   [Kamamoto, Fabio] Univ Sao Paulo, Fac Med, Hosp Clin, Univ Hosp, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Ferreira, MC (通讯作者)，Rua Barata Ribeiro 483,Conj 161 & 162,Bela Vista, BR-01308000 Sao Paulo, Brazil.
EM mferrei@uol.com.br
RI Paggiaro, Andr�/F-1570-2016; Carvalho, Viviane/H-9511-2013
OI Carvalho, Viviane/0000-0002-0807-0586
CR Abbott CA, 2002, DIABETIC MED, V19, P377, DOI 10.1046/j.1464-5491.2002.00698.x
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NR 27
TC 12
Z9 17
U1 2
U2 16
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PD MAY 7
PY 2009
VL 127
IS 3
BP 166
EP 170
DI 10.1590/S1516-31802009000300010
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 505IH
UT WOS:000270685700010
PM 19820878
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Childress, B
   Stechmiller, JK
   Schultz, GS
AF Childress, Beverly
   Stechmiller, Joyce K.
   Schultz, Gregory S.
TI Arginine metabolites in wound fluids from pressure ulcers: A pilot study
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE arginine; nitric oxide; negative pressure; wound therapy; wound healing;
   pressure ulcer
ID NITRIC-OXIDE-SYNTHASE; EXPRESSION; REPAIR; CONTAMINATION; INHIBITION;
   CYTOKINES; PROTEASES; ISOFORMS; ARGINASE; COLLAGEN
AB Compelling evidence suggests that nitric oxide (NO center dot), a metabolite of arginine, plays an important role in wound healing. Arginine is a semi-essential amino acid that is metabolized by nitric oxide synthase and arginase. One model for wound-healing regulation suggests the importance of strict reciprocal control of these enzymes in wounds. The purpose of this pilot study was to investigate arginine metabolism in wound fluids from patients with Stage III or IV pressure ulcers receiving negative pressure wound therapy (NPWT). Wound fluids were collected from 8 patients, aged 31-79 years, before and after initiation of NPWT on Days 1, 3, and 7. Wound fluids were analyzed for nitrates/nitrites (NOx), arginine, citrulline, proline, and ornithine. There were no significant differences between NO,, arginine, citrulline, proline, and ornithine concentrations before and after initiation of NPWT among the various timepoints. However, we observed a downward trend of NO center dot levels from baseline to Day 7 of NPWT treatment. Furthermore, we detected a decrease in arginine levels over the study period, suggesting that the iNOS/citrulline pathway predominated during the first 72 hr of treatment, and the arginase/ornithine pathway dominated thereafter. Arginine and its metabolites are detectable in wound fluids from patients with Stage III or IV pressure ulcers on NPWT. Further studies on chronic wounds are warranted to correlate wound-healing outcomes with arginine metabolites at the cellular and molecular level over a longer period of time.
C1 [Childress, Beverly] VA Off Acad Affiliat, N Florida S Georgia Vet Hlth Syst, Gainesville, FL 32608 USA.
   [Stechmiller, Joyce K.] Univ Florida, Coll Nursing, Adult & Elderly Dept, Gainesville, FL 32611 USA.
   [Schultz, Gregory S.] Univ Florida, Coll Med, Dept Obstet & Gynecol, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Childress, B (通讯作者)，VA Off Acad Affiliat, N Florida S Georgia Vet Hlth Syst, 1601 SW Archer Rd,Vasc 112, Gainesville, FL 32608 USA.
EM Beverly.Childress@va.gov
FU Sigma Theta Tau International; Florida Nurses Foundation; Kinetic
   Concepts, Inc
FX This work was partially supported by grants from the Alpha Theta Tau
   chapter of Sigma Theta Tau International, the Florida Nurses Foundation,
   and Kinetic Concepts, Inc.
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NR 30
TC 9
Z9 12
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2008
VL 10
IS 2
BP 87
EP 92
DI 10.1177/1099800408322215
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 353VI
UT WOS:000259596200002
PM 18829591
DA 2026-07-24
ER

PT J
AU Kakulamarri, S
   Wahle, CF
   Smith, L
   Sabharwal, S
AF Kakulamarri, Shravya
   Wahle, Charlotte F.
   Smith, Lacey
   Sabharwal, Sanjeev
TI Frugal Innovations in Orthopaedics
SO CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
LA English
DT Review
DE Frugal innovation; Low-cost technologies; Global health; Surgical
   access; Orthopaedic surgery
ID PRESSURE WOUND THERAPY; GLOBAL BURDEN; DELIVERY; DISEASE; SYSTEM
AB Purpose of ReviewFrugal innovations prioritize low-cost interventions, while keeping in mind efficacy, accessibility and scalability. Despite a scientific culture that often celebrates major financial investment and cutting-edge technologies, frugal innovations can be just as important in both low-income countries where resources are scarce as they are high income countries where the health needs of aging populations may be outpacing economic growth. We sought to comprehensively review the current state of frugal innovations in orthopaedic surgery, as well as to identify next steps as the importance of these low-cost interventions continues to grow.Recent FindingsFrugal innovation is particularly relevant in orthopaedic care as musculoskeletal interventions such as prosthetics, orthotics and surgery demand significant materials, skilled labor, and frequent follow-up. There have been numerous innovations in the recent years, including the development of low-cost intramedullary nails, bioabsorbable implants, negative-pressure wound therapy systems made from aquarium pumps, repurposed Foley catheters and nasogastric tubes for use in surgeries, among many more.SummaryFrugal innovations in orthopaedic surgery are becoming more relevant and rapidly evolving in all health-care settings as a tool to deliver value-based care to the growing needs of the population. Though many of these projects are performed on a local scale, when considered collectively, they demonstrate powerful efforts to move the needle in enhancing access to high-quality orthopaedic surgical care and reduce the burden of global musculoskeletal disability. Frugal innovations offer immense promise in reducing costs and closing the gap of access to high-quality orthopaedic care worldwide
C1 [Kakulamarri, Shravya; Wahle, Charlotte F.; Smith, Lacey] Univ Calif San Francisco, Inst Global Orthopaed & Traumatol, San Francisco, CA USA.
   [Sabharwal, Sanjeev] Univ Calif San Francisco, Benioff Childrens Hosp, 747 52nd St, Oakland, CA 94609 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   UCSF Medical Center; UCSF Benioff Children's Hospital Oakland
RP Sabharwal, S (通讯作者)，Univ Calif San Francisco, Benioff Childrens Hosp, 747 52nd St, Oakland, CA 94609 USA.
EM Sanjeev.Sabharwal@ucsf.edu
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NR 69
TC 0
Z9 1
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1935-973X
EI 1935-9748
J9 CURR REV MUSCULOSKE
JI Curr. Rev. Musculoskelet. Med.
PD DEC
PY 2025
VL 18
IS 12
BP 568
EP 576
DI 10.1007/s12178-025-09985-4
EA JUN 2025
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 7LO8W
UT WOS:001513471200001
PM 40549111
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Pingpoh, C
   Kondov, S
   Schroefel, H
   Kreibich, M
   Puiu, P
   Kueri, S
   Berger, T
   Beyersdorf, F
   Siepe, M
   Czerny, M
AF Pingpoh, Clarence
   Kondov, Stoyan
   Schroefel, Holger
   Kreibich, Maximillian
   Puiu, Paul
   Kueri, Sami
   Berger, Tim
   Beyersdorf, Friedhelm
   Siepe, Matthias
   Czerny, Martin
TI Efficacy of Vascular Closure Devices in Closing Large-Bore Sheath
   Arterial Sites after Treatment with Extracorporeal Life Support System
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article
DE cardiac; endovascular; complications; incisions; wound infections
ID ACCESS
AB Background We retrospectively evaluated vascular complications and wound infections after surgical or percutaneous transfemoral removal of temporary extracorporeal life support systems (ECLSs).
   Methods A total of 83 patients were weaned from ECLS between August 2015 and September 2020. We analyzed for a composite endpoint of vascular complications and wound infections requiring negative-pressure wound therapy. Patients were divided into two groups: percutaneous group using the MANTA vascular occlusion system (VCD; Teleflex, Morrisville, North Carolina, United States) ( n =23) and surgical group ( n =60).
   Results The median age in the entire cohort was 67 years. Vascular complications were seen in 20% ( n =12) in the surgical group and in 13% ( n =3) in the percutaneous group ( p =0.72). A total of 32% ( n =19) in the surgical group and 9% ( n =2) in the percutaneous group ( p =0.031) had wound infections. A composite endpoint of vascular complications and wound infections showed significantly more complications in the surgical group (52%, n =31) as compared with the percutaneous group (22%, n =5) ( p =0.020). The median duration in the intensive care unit was 13 days for the surgical group and 12 days for the percutaneous group without any significant difference in both groups ( p =0.93).
   Conclusions Using the MANTA VCD for percutaneous removal of ECLS cannulas after weaning from ECLS is safe and reproducible. A composite endpoint of vascular complications and wound infections was significantly lower in the percutaneous removal group as compared with the surgical group.
C1 [Pingpoh, Clarence; Kondov, Stoyan; Schroefel, Holger; Kreibich, Maximillian; Puiu, Paul; Kueri, Sami; Berger, Tim; Beyersdorf, Friedhelm; Siepe, Matthias; Czerny, Martin] Univ Heart Ctr Freiburg, Dept Cardiovasc Surg, Suedring 15, D-79189 Bad Krozingen, Germany.
   [Pingpoh, Clarence; Kondov, Stoyan; Schroefel, Holger; Kreibich, Maximillian; Puiu, Paul; Kueri, Sami; Berger, Tim; Beyersdorf, Friedhelm; Siepe, Matthias; Czerny, Martin] Albert Ludwigs Univ Freiburg, Fac Med, Freiburg, Germany.
C3 Universitats Herzzentrum Freiburg; University of Freiburg
RP Pingpoh, C (通讯作者)，Univ Heart Ctr Freiburg, Dept Cardiovasc Surg, Suedring 15, D-79189 Bad Krozingen, Germany.
EM Clarence.Pingpoh@universitaets-herzzentrum.de
RI Kueri, Sami/AAE-8041-2021; Beyersdorf, Friedhelm/AAK-3718-2020; Siepe,
   Matthias/AAF-9846-2019; Kreibich, Maximilian/AAA-7396-2021; Kondov,
   Stoyan/PDX-9734-2025; Berger, Tim/JHU-4476-2023
OI Kueri, Sami/0000-0002-1019-1432; Beyersdorf,
   Friedhelm/0000-0003-2975-2751; Puiu, Paul-Cătălin/0000-0001-8112-5566; 
FU University Heart Center Freiburg-Bad Krozingen
FX This trial was supported by the University Heart Center Freiburg-Bad
   Krozingen.
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NR 11
TC 10
Z9 10
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD SEP
PY 2021
VL 69
IS 06
BP 537
EP 541
DI 10.1055/s-0041-1728708
EA AUG 2021
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA US6MS
UT WOS:000683517800003
PM 34376000
DA 2026-07-24
ER

PT J
AU Bertoglio, CL
   Morini, L
   Barone, G
   Girardi, V
   Bozzo, S
   Ferrari, G
AF Bertoglio, Camillo Leonardo
   Morini, Lorenzo
   Barone, Gisella
   Girardi, Valerio
   Bozzo, Samantha
   Ferrari, Giovanni
TI Synchronous Surgical Treatment of Morbid Obesity and Complex Ventral
   Hernia After Progressive Pneumoperitoneum and Botulinum Toxin A
   Injection
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Complex ventral hernia; Progressive pneumoperitoneum; Botulin toxin A
AB Introduction The worldwide increase in morbidly obese patients with complex hernia raises controversies in the choice of the appropriate treatment timing: synchronous bariatric and abdominal wall surgery versus delayed abdominal wall surgery. We report an innovative tailored surgical treatment carried out at our Institution. Patient and Methods The approach provided the injection, 6 weeks before surgery, of 500 IU of botulinum toxin A on either side of the large abdominal wall muscles. Four weeks before surgery, pneumoperitoneum was inducted and out-patient daily sessions of progressive insufflation with ambient air were then carried out. Surgery was scheduled 48 days after botulinum injection. Sleeve gastrectomy and simultaneous posterior component separation with transversus abdominis release were performed. Two prosthetic meshes were placed sublay. Postoperative superficial surgical site infection was successfully treated with negative pressure wound therapy. At a 1-year follow-up, no hernia recurrence was recorded while total body weight loss was 31%. Discussion A delay in ventral hernia repair could worsen the quality of life of morbidly obese patients. In such high-risk patients, the choice of the best surgical strategy remains controversial. There is great concern in performing bariatric surgery simultaneously to hernia repair, although there is lack of evidence on which is the ideal treatment modality. Conclusion Synchronous bariatric surgery and complex ventral hernia repair should be approached in high-volume centres where a consolidated experience of multidisciplinary teamwork is available. Combined botulinum toxin A and preoperative progressive pneumoperitoneum administration allow for a safe resolution of loss of domain.
C1 [Bertoglio, Camillo Leonardo; Morini, Lorenzo; Barone, Gisella; Girardi, Valerio; Bozzo, Samantha; Ferrari, Giovanni] ASST Grande Osped Metropolitano Niguarda, Niguarda Gen Hosp, Div Oncol & Minimally Invas Surg, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
RP Bertoglio, CL (通讯作者)，ASST Grande Osped Metropolitano Niguarda, Niguarda Gen Hosp, Div Oncol & Minimally Invas Surg, Piazza Osped Maggiore 3, I-20162 Milan, Italy.
EM camilloleonardo.bertoglio@ospdealeniguarda.it
RI ; Bertoglio, Camillo Leonardo/K-8111-2017; /AAK-1893-2020
OI Morini, Lorenzo/0000-0001-5191-0045; Girardi,
   Valerio/0000-0001-6436-8208; Barone, Gisella/0000-0001-8473-1107; bozzo,
   samantha/0000-0002-4351-4947; Bertoglio, Camillo
   Leonardo/0000-0002-5925-983X; 
CR García-Ureña MA, 2019, WORLD J SURG, V43, P149, DOI 10.1007/s00268-018-4765-9
   Birkmeyer JD, 2013, NEW ENGL J MED, V369, P1434, DOI 10.1056/NEJMsa1300625
   Bittner R, 2019, SURG ENDOSC, V33, P3069, DOI 10.1007/s00464-019-06907-7
   Bueno-Lledó J, 2020, FRONT SURG, V7, DOI 10.3389/fsurg.2020.00003
   Çakmak M, 2006, J PEDIATR SURG, V41, P821, DOI 10.1016/j.jpedsurg.2005.12.023
   Ibarra-Hurtado TR, 2009, WORLD J SURG, V33, P2553, DOI 10.1007/s00268-009-0203-3
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Lo Menzo E, 2018, SURG OBES RELAT DIS, V14, P1221, DOI 10.1016/j.soard.2018.07.005
   Olmi S, 2020, J LAPAROENDOSC ADV S, V30, P749, DOI 10.1089/lap.2019.0781
   Owei L, 2019, HERNIA, V23, P899, DOI 10.1007/s10029-019-01944-6
   Quraishi AHM, 2013, UPDATES SURG-ITALY, V65, P165, DOI 10.1007/s13304-012-0134-7
   Raj PP, 2019, SURG OBES RELAT DIS, V15, P1098, DOI 10.1016/j.soard.2019.04.027
   Shabanzadeh DM, 2012, ANN SURG, V256, P934, DOI 10.1097/SLA.0b013e318269a46b
   Slater NJ, 2014, HERNIA, V18, P7, DOI 10.1007/s10029-013-1168-6
   Varela JE, 2009, SURG OBES RELAT DIS, V5, P524, DOI 10.1016/j.soard.2009.04.003
NR 15
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD DEC
PY 2021
VL 83
IS 6
BP 1552
EP 1556
DI 10.1007/s12262-021-02764-8
EA FEB 2021
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XM9CU
UT WOS:000616165300002
DA 2026-07-24
ER

PT J
AU Acosta, S
   Monsen, C
AF Acosta, S.
   Monsen, C.
TI Outcome after VAC® Therapy for Infected Bypass Grafts in the Lower Limb
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE VAC; Negative pressure wound therapy; Bypass; Graft infection; Wound
   healing; Amputation; Mortality
ID VASCULAR GRAFT; GROIN; CLOSURE
AB Objective: To assess the outcome of vacuum-assisted wound closure (VAC (R)) therapy for infected bypass grafts.
   Methods: A retrospective 7-year review of patient records from 2004 to 2011 of all patients receiving VAC (R) therapy for infected bypass grafts.
   Results: Thirty-seven patients with 42 wounds and 45 infected bypass (28 synthetic) grafts received VAC (R) treatment. Two serious bleeding episodes from the suture lines occurred. The median VAC (R) therapy time was 20 days. The proportion of patent bypass grafts was 91% (41/45) at a median time of 3.5 months from the start of VAC (R) therapy. Five patients with seven bypasses had persistent infection or re-infection, and the total graft preservation rate was 76% (34/45). The median follow-up time was 15 months. The presence of two infected bypass grafts in one groin wound was associated with an increased major amputation rate (hazard ratio (HR) 7.4 [95% confidence interval (CI) 2.0-27.5]), and synthetic graft infection (HR 5.0 [95% CI 1.5-17.4]) and non-healed wound (HR 3.6 [95% CI 1.5-8.7]) were associated with mortality.
   Conclusion: VAC (R) therapy of infected bypass grafts was able to induce effective wound healing without compromising the early bypass function. Two infected synthetic bypasses in the wound were associated with the highest risk of adverse outcome. (C) 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Acosta, S.; Monsen, C.] Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
C3 Lund University; Skane University Hospital
RP Acosta, S (通讯作者)，Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023; Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798; Acosta, Stefan/0000-0002-8895-6001
CR Armstrong PA, 2007, J VASC SURG, V46, P71, DOI 10.1016/j.jvs.2007.02.058
   Barani J, 2005, J VASC SURG, V42, P75, DOI 10.1016/j.jvs.2005.03.025
   Berger P, J VASC SURG
   Comerota AJ, 1996, AM J SURG, V172, P105, DOI 10.1016/S0002-9610(96)00129-8
   Dee A, 2007, J Wound Care, V16, P42
   Fischer J, 2011, J VASC SURG
   Grubb A, 2005, CLIN CHEM, V51, P1420, DOI 10.1373/clinchem.2005.051557
   Herscu G, 2009, SURG CLIN N AM, V89, P391, DOI 10.1016/j.suc.2008.09.007
   Kragsterman B, 2011, J ENDOVASC THER, V18, P666, DOI 10.1583/11-3465.1
   Mayer D, 2011, ANN SURG, V254, P754, DOI 10.1097/SLA.0b013e3182365864
   Pinocy J, 2003, WOUND REPAIR REGEN, V11, P104, DOI 10.1046/j.1524-475X.2003.11205.x
   Reiffel A, 2011, ANN VASC SURG
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   SZILAGYI DE, 1972, ANN SURG, V176, P321, DOI 10.1097/00000658-197209000-00008
   Taylor SM, 1996, ANN VASC SURG, V10, P117, DOI 10.1007/BF02000754
   Wilson S E, 2001, Surg Infect (Larchmt), V2, P171, DOI 10.1089/109629601750469492
NR 16
TC 18
Z9 19
U1 0
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD SEP
PY 2012
VL 44
IS 3
BP 294
EP 299
DI 10.1016/j.ejvs.2012.06.005
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 013KE
UT WOS:000309303500015
PM 22818802
DA 2026-07-24
ER

PT J
AU Soto, AL
   Olszewski, TM
   Barr, J
AF Soto, Alexandria L.
   Olszewski, Todd M.
   Barr, Justin
TI Medicine's Glass Slipper: The PAVAEX Boot and 20th Century Negative
   Pressure Therapy
SO AMERICAN SURGEON
LA English
DT Article
DE peripheral arterial disease; negative pressure therapy; wound healing;
   vascular surgery; PAVAEX Boot; Louis Herrmann; history; history of
   medicine
ID EXTREMITIES
AB Before the 20th century, peripheral artery disease (PAD) manifested as extreme pain, chronic wounds, and, eventually, gangrene requiring amputation. Despite this, it was rarely diagnosed. However, at the turn of the century, Western medicine shifted focus from infectious to chronic illnesses, and with this change, physicians' engagement with PAD transformed. Aiming to mitigate long-term injury, physicians now worked to identify and treat vessel disease to restore meaningful blood circulation. This article explores the development and deployment of a new device resulting from this refocus, the PAssive VAscular EXerciser (PAVAEX) Boot, and its role as a creative response to a previously intractable clinical problem. The PAVAEX Boot, designed in 1933 by vascular surgeons Louis G. Herrmann and Mont R. Reid, was one of the few interventions for PAD at the time. Based on the observation that continuous negative pressure results in vasoconstriction, while short bursts transiently increase blood flow, the PAVAEX Boot utilized intermittent negative pressure to enhance peripheral vascular perfusion. Well-marketed and praised throughout the 1930s, it vanished from public writing and academic literature just 20 years later. However, negative pressure wound therapy resurged in the late 20th century, and though its inventors failed to recognize the precedent of the PAVAEX Boot, many of these devices and therapies are rooted in identical theories. We examine why the PAVAEX Boot faded from use and argue that the device remains a crucial advancement in negative pressure therapy.
C1 [Soto, Alexandria L.] Duke Univ, Sch Med, 40 Duke Med Circle,124 Davison Bldg, Durham, NC 27710 USA.
   [Soto, Alexandria L.] Harvard Univ, Dept Hist Sci, Cambridge, MA USA.
   [Olszewski, Todd M.] Providence Coll, Dept Hlth Sci, Providence, RI USA.
   [Barr, Justin] Univ Toronto, Dept Surg, Toronto, ON, Canada.
C3 Duke University; Harvard University; Providence College; University of
   Toronto
RP Soto, AL (通讯作者)，Duke Univ, Sch Med, 40 Duke Med Circle,124 Davison Bldg, Durham, NC 27710 USA.
EM Alexandria.soto@duke.edu
RI ; Soto, Alexandria/IVV-3550-2023; Olszewski, Todd/AAC-6514-2021
OI Barr, Justin/0000-0003-0143-0603; Soto, Alexandria/0000-0003-1742-5251;
   Olszewski, Todd/0009-0002-6886-3825
CR Allen AW, 1930, ANN SURG, V92, P931
   [Anonymous], 1965, ESC Q MED PROFESSION, V23, P44
   [Anonymous], 1936, PAVAEX PASSIVE VASCU, P1
   [Anonymous], 1935, DETROIT JEWISH CHRON, V37, P6
   Blume D., 1938, PERIPHERAL VASCULAR
   Circulator Boot-Product Overview, 2023, AM MED EQ
   de Takats G, 1937, J AMER MED ASSOC, V108, P1951, DOI 10.1001/jama.1937.02780230011004
   Herrmann LG, 1934, ANN SURG, V100, P750, DOI 10.1097/00000658-193410000-00016
   Herrmann LG, 1934, ARCH SURG-CHICAGO, V29, P697, DOI 10.1001/archsurg.1934.01180050002001
   Herrmann LG., 1969, NATL CYCLOPAEDIA AM, P706
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   Hoel H, 2021, J VASC SURG, V73, P1750, DOI 10.1016/j.jvs.2020.10.024
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   Reid R, 1935, ANN SURG, V102, P321, DOI 10.1097/00000658-193509000-00001
   Sundby OH, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12998
   Sundby OH, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12911
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NR 25
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2024
VL 90
IS 11
BP 3164
EP 3169
DI 10.1177/00031348241259041
EA JUN 2024
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J1B9N
UT WOS:001238161400001
PM 38830241
DA 2026-07-24
ER

PT J
AU Obeid, N
   Sharma, E
   Dunstan, M
   Nisar, P
   Trivedi, P
   Madani, R
   Scott, HJ
   Trickett, JP
   Bearn, PE
   Thomas, GP
AF Obeid, N.
   Sharma, E.
   Dunstan, M.
   Nisar, P.
   Trivedi, P.
   Madani, R.
   Scott, H. J.
   Trickett, J. P.
   Bearn, P. E.
   Thomas, G. P.
TI Negative pressure therapy for stoma closure sites-a nonrandomised case
   control study
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE PICO; Stoma closure
ID WOUND THERAPY; REVERSAL; INFECTIONS; TRIAL; RISK
AB Aim The PICO (Smith & Nephew, UK) dressing is a single use negative pressure wound therapy (NPWT) system that is designed to be used for up to 7 days for closed wounds. We aimed to assess its use for stoma closure wounds. Method We conducted a retrospective analysis of stoma reversal wounds from April 2018 to June 2019. The wound was partially closed with an absorbable subcutaneous suture in a purse-string fashion. A 15 cm x 15 cm PICO dressing was applied directly over this wound. A control group who had received partial purse string closure with packing over the same time period was identified. Patients were contacted and information collected using a questionnaire. The primary outcome measure was the number of visits for dressing changes in the community. Further information was collected about length of stay, time to resolution of pain and return to work. Results On average, the patients with PICO dressings attended the community nurses 1.9 times. The patients in the PICO group stated it took 1-2 weeks to return to full work/daily activities. The control group averaged attending the community nurse 11.9 times, and 33% had not returned to work/daily activities in 1-2 weeks. Conclusion Those who had a PICO dressing required fewer visits to the community nurse and the majority were able to return to work or resume usual activities within 1 to 2 weeks. This pilot study suggests that negative pressure dressings may be a useful aid for stoma closure site wounds.
C1 [Obeid, N.; Sharma, E.; Dunstan, M.; Nisar, P.; Trivedi, P.; Madani, R.; Scott, H. J.; Trickett, J. P.; Bearn, P. E.; Thomas, G. P.] Ashford & St Peters NHS Trust, Dept Colorectal Surg, Lyne, Surrey, England.
RP Obeid, N (通讯作者)，Ashford & St Peters NHS Trust, Dept Colorectal Surg, Lyne, Surrey, England.
EM noor.obeid@nhs.net
OI Dunstan, Matt/0000-0002-5383-9921
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Hajibandeh S, 2018, INT J COLORECTAL DIS, V33, P1319, DOI 10.1007/s00384-018-3139-y
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Malmsjo Malin, 2014, Eplasty, V14, pe15
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   Miller Christine, 2012, J Am Coll Clin Wound Spec, V4, P61, DOI 10.1016/j.jccw.2013.11.002
   O'Leary DP, 2017, ANN SURG, V265, P1082, DOI 10.1097/SLA.0000000000002098
   Poehnert D, 2017, WOUND REPAIR REGEN, V25, P994, DOI 10.1111/wrr.12606
   Rondelli F, 2018, INT J SURG, V52, P208, DOI 10.1016/j.ijsu.2018.02.027
   Sinha K, 2013, ADV ORTHOP, V2013, DOI 10.1155/2013/245940
   van der Valk MJM, 2017, ADV WOUND CARE, V6, P425, DOI 10.1089/wound.2017.0749
NR 19
TC 6
Z9 7
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JAN
PY 2021
VL 36
IS 1
BP 161
EP 167
DI 10.1007/s00384-020-03749-x
EA SEP 2020
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA PO1YK
UT WOS:000569306000001
PM 32929529
DA 2026-07-24
ER

PT J
AU Ding, HX
   Wang, WW
   Yuan, MY
   Tang, JJ
   Zhou, JH
   Pan, JS
AF Ding, Haixiang
   Wang, Wenwen
   Yuan, Mingyang
   Tang, Junjan
   Zhou, Jianhong
   Pan, Jingshi
TI Multidisciplinary management of severe open pelvic fracture with
   multiple organ injuries: A case report
SO MEDICINE
LA English
DT Article
DE case report; damage control surgery; multidisciplinary management; open
   pelvic fractures; staged surgical approach
AB Rationale:Open pelvic fractures represent severe traumatic injuries with mortality rates approaching 50%. Complex cases involving multiple organ injuries and massive hemorrhage pose significant challenges in clinical management. Despite advances in trauma care, comprehensive documentation of successful management strategies for severe open pelvic fractures with multiple complications remains limited.Patient concerns:A 36-year-old female presented with an open pelvic fracture following a motor vehicle collision, complicated by hemorrhagic shock (blood pressure 66/45 mm Hg), multiple organ injuries including bladder rupture and rectal damage, and an 18-cm open wound from the right groin to the anus with active bleeding.Diagnoses:Young and Burgess anterior-posterior compression III type pelvic fracture with vertical shear mechanism, bilateral internal iliac artery injuries, complete bladder and urethral rupture, and extensive perineal-rectal injuries.Interventions:The patient underwent multiple staged interventions including emergency arterial embolization and stenting, external pelvic fixation, bladder repair, sigmoid colostomy, serial wound debridements, negative pressure wound therapy, and final reconstruction with muscle flap transposition and skin grafting. Treatment required 148 days of hospitalization, including 22 days in intensive care unit.Outcomes:The patient achieved successful recovery with healed fractures and wounds, though requiring permanent colostomy and cystostomy. Rehabilitation enabled functional recovery and return to daily activities.Lessons:Successful management of complex open pelvic fractures requires prompt hemorrhage control through interventional procedures, implementation of damage control principles with staged surgical approaches, close multidisciplinary collaboration, and comprehensive wound care and infection management. This strategy can significantly improve survival outcomes in severe cases.
C1 [Ding, Haixiang; Yuan, Mingyang; Zhou, Jianhong; Pan, Jingshi] Jiangnan Univ, Dept Trauma Surg, Affiliated Hosp, 1000 Hefeng Rd, Wuxi 214000, Jiangsu, Peoples R China.
   [Wang, Wenwen] Wuxi Hlth Vocat Coll, Dept Pharm, Wuxi, Jiangsu, Peoples R China.
   [Tang, Junjan] Jiangnan Univ, Affiliated Hosp, Dept Vasc Surg, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Pan, JS (通讯作者)，Jiangnan Univ, Dept Trauma Surg, Affiliated Hosp, 1000 Hefeng Rd, Wuxi 214000, Jiangsu, Peoples R China.
EM haixiangding001@gmail.com; 513279244@qq.com; 1562629313@qq.com;
   3943483632@qq.com; 1562629314@qq.com; jingshipan001@163.com
RI ding, haixiang/KZU-4960-2024
CR Asensio Juan A, 2003, Proc (Bayl Univ Med Cent), V16, P294
   Benders KEM, 2020, FRONT SURG, V7, DOI 10.3389/fsurg.2020.601321
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   Faisal M., 2022, J Clin Med, V11, P1290
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   Kanakaris NK, 2022, EUR J TRAUMA EMERG S, V48, P3701, DOI 10.1007/s00068-021-01618-y
   Mi M, 2021, INJURY, V52, P2738, DOI 10.1016/j.injury.2020.02.096
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   Montmany S, 2015, CIR ESPAN, V93, P450, DOI 10.1016/j.ciresp.2015.01.011
   Obrand J, 2024, J VAS SURG CASES IN, V10, DOI 10.1016/j.jvscit.2023.101410
   Perumal Ramesh, 2021, J Clin Orthop Trauma, V12, P101, DOI 10.1016/j.jcot.2020.09.035
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NR 25
TC 1
Z9 2
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 1
PY 2025
VL 104
IS 31
AR e43551
DI 10.1097/MD.0000000000043551
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5RH9M
UT WOS:001542477100009
PM 40760631
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gotlin, MJ
   Catalano, W
   Levine, JP
   Egol, KA
AF Gotlin, Matthew J.
   Catalano, William
   Levine, Jamie P.
   Egol, Kenneth A.
TI Wound Closure Following Intervention for Closed Orthopedic Trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Review
DE Surgical site infection; Wound closure; Staples; Sutures; Wound healing
ID SURGICAL-SITE INFECTION; POVIDONE-IODINE SOLUTION; ANKLE FRACTURES;
   RISK-FACTORS; LOWER-LIMB; THERAPY; SURGERY; PREVENTION; MANAGEMENT; SKIN
AB The method of skin closure and post-operative wound management has always been important in orthopedic surgery and plays an even larger role now that surgical site infection (SSI) is a national healthcare metric for both surgeons and hospitals. Wound related issues remain some of the most feared complications following orthopedic trauma procedures and are associated with significant morbidity. In order to minimize the risk of surgical site complications, surgeons must be familiar with the physiology of wound healing as well as the patient and surgical factors affecting healing potential. The goal of all skin closure techniques is to promote rapid healing with acceptable cosmesis, all while minimizing risk of infection and dehiscence. Knowledge of the types of closure material, techniques of wound closure, surgical dressings, negative pressure wound therapy, and other local modalities is important to optimize wound healing. There is no consensus in the literature as to which closure method is superior but the available data can be used to make informed choices. Although often left to less experienced members of the surgical team, the process of wound closure and dressing the wound should not be an afterthought, and instead must be part of the surgical plan. Wounds that are in direct communication with bony fractures are particularly at risk due to local tissue trauma, resultant swelling, hematoma formation, and injured vasculature. (c) 2021 Elsevier Ltd. All rights reserved.
C1 [Gotlin, Matthew J.; Catalano, William; Egol, Kenneth A.] NYU Langone Hlth, NYU Langone Orthoped Hosp, Dept Orthoped Surg, 301 East 17th St, New York, NY 10003 USA.
   [Levine, Jamie P.] NYU Langone Hlth, Dept Plast Surg, 222 East 41st St, New York, NY 10017 USA.
C3 NYU Langone Medical Center; NYU Langone Medical Center
RP Gotlin, MJ (通讯作者)，NYU Langone Hlth, NYU Langone Orthoped Hosp, Dept Orthoped Surg, 301 East 17th St, New York, NY 10003 USA.
EM matt.gotlin@gmail.com
OI Levine, Jamie/0009-0009-6163-8490
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NR 77
TC 5
Z9 6
U1 0
U2 16
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2022
VL 53
IS 2
BP 313
EP 322
DI 10.1016/j.injury.2021.11.062
EA JAN 2022
PG 10
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA YR2AD
UT WOS:000749798400015
PM 34865820
DA 2026-07-24
ER

PT J
AU Serna, C
   Serna, JJ
   Caicedo, Y
   Padilla, N
   Gallego, LM
   Salcedo, A
   Rodríguez-Holguín, F
   González-Hadad, A
   García, A
   Herrera, MA
   Parra, MW
   Ordonez, CA
AF Serna, Carlos
   Julian Serna, Jose
   Caicedo, Yaset
   Padilla, Natalia
   Gallego, Linda M.
   Salcedo, Alexander
   Rodriguez-Holguin, Fernando
   Gonzalez-Hadad, Adolfo
   Garcia, Alberto
   Alain Herrera, Mario
   Parra, Michael W.
   Ordonez, Carlos A.
TI Damage control surgery for splenic trauma: "preserve an organ - preserve
   a life"
SO COLOMBIA MEDICA
LA English
DT Review
DE Spleen; injury severity score; splenectomy; laparotomy; focused
   assessment with sonography for trauma; advanced trauma life support
   care; damage control surgery; negative-pressure wound therapy; balloon
   occlusion; REBOA
ID NONOPERATIVE MANAGEMENT; ARTERY EMBOLIZATION; BLUNT; INJURY; FAILURE;
   STRATEGIES; ADULTS
AB The spleen is one of the most commonly injured solid organs of the abdominal cavity and an early diagnosis can reduce the associated mortality. Over the past couple of decades, management of splenic injuries has evolved to a prefered non-operative approach even in severely injured cases. However, the optimal surgical management of splenic trauma in severely injured patients remains controversial. This article aims to present an algorithm for the management of splenic trauma in severely injured patients, that includes basic principles of damage control surgery and is based on the experience obtained by the Trauma and Emergency Surgery Group (CTE) of Cali, Colombia. The choice between a conservative or a surgical approach depends on the hemodynamic status of the patient. In hemodynamically stable patients, a computed tomography angiogram should be performed to determine if non-operative management is feasible and if angioembolization is required. While hemodynamically unstable patients should be transferred immediately to the operating room for damage control surgery, which includes splenic packing and placement of a negative pressure dressing, followed by angiography with embolization of any ongoing arterial bleeding. It is our recommendation that both damage control principles and emerging endovascular technologies should be applied to achieve splenic salvage when possible. However, if surgical bleeding persists a splenectomy may be required as a definitive lifesaving maneuver.
C1 [Serna, Carlos; Julian Serna, Jose; Salcedo, Alexander; Gonzalez-Hadad, Adolfo; Garcia, Alberto; Alain Herrera, Mario; Ordonez, Carlos A.] Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Salcedo, Alexander; Gonzalez-Hadad, Adolfo; Alain Herrera, Mario] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Salcedo, Alexander; Rodriguez-Holguin, Fernando; Garcia, Alberto; Ordonez, Carlos A.] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Julian Serna, Jose; Gallego, Linda M.; Salcedo, Alexander; Garcia, Alberto; Ordonez, Carlos A.] Univ ICESI, Cali, Colombia.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo] Ctr Med Imbanaco, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
C3 Universidad del Valle; Universidad del Valle; Fundacion Valle del Lili;
   Universidad ICESI; Fundacion Valle del Lili
RP Ordonez, CA (通讯作者)，Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.; Ordonez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordonez, CA (通讯作者)，Univ ICESI, Cali, Colombia.
EM ordonezcarlosa@gmail.com
RI ; Herrera, Mario Alain/LRB-9290-2024
OI Gallego, Linda Melissa/0000-0001-9081-5016; Salcedo Cadavid,
   Alexander/0000-0001-8187-0638; Herrera, Mario Alain/0000-0002-4526-7636;
   Serna, José Julián/0000-0001-9829-8930; Padilla-Londoño,
   Natalia/0000-0003-3292-6919
CR Ordoñez CA, 2012, J TRAUMA ACUTE CARE, V73, P1074, DOI 10.1097/TA.0b013e31826fc780
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   Ordonez C, PANAM J TRAUMA CRIT, V20165, P110, DOI [DOI 10.5005/JP-JOURNALS-10030-1262, 10.5005/jp- journals-10030-1262]
   Ordoñez C, 2020, COLOMB MEDICA, V51
   Ordoñez C, 2012, WORLD J SURG, V36, P2761, DOI 10.1007/s00268-012-1745-3
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   Requarth JA, 2011, J TRAUMA, V71, P898, DOI 10.1097/TA.0b013e318227ea50
   Rosati C, 2015, AM J SURG, V209, P308, DOI 10.1016/j.amjsurg.2014.06.034
   Shapiro MJ, 1999, J TRAUMA, V47, P651, DOI 10.1097/00005373-199910000-00008
   Skattum J, 2012, BRIT J SURG, V99, P59, DOI 10.1002/bjs.7764
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   Smith J, 2008, J TRAUMA, V64, P656, DOI 10.1097/TA.0b013e3181650fb4
   Teuben M, 2019, EUR J TRAUMA EMERG S, V45, P979, DOI 10.1007/s00068-019-01117-1
NR 32
TC 4
Z9 6
U1 0
U2 8
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2021
VL 52
IS 2
AR e4084794
DI 10.25100/cm.v52i2.4794
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TK0ND
UT WOS:000673865600003
PM 34188324
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pharr, T
   Billingsley, J
   Docimo, S
AF Pharr, Trevor
   Billingsley, Jenna
   Docimo, Salvatore
TI Successful salvage of bioresorbable mesh (Poly-4-hydroxybutyrate)
   following complicated hernia repair: a case series and systematic review
SO HERNIA
LA English
DT Article
DE Bioresorbable mesh; Mesh salvage; Ventral hernia repair;
   Poly-4-hydroxybutyrate
AB PurposeBioresorbable mesh is becoming increasingly common in complex cases. However, the outcomes of mesh salvage following complicated hernia repair with bioresorbable mesh have not been well-characterized. We report a series of three cases involving the salvage of poly-4-hydroxybutyrate (P4HB) bioresorbable mesh following ventral hernia repair (VHR).MethodsWe conducted a systematic review of the literature to elicit current outcomes of hernia mesh salvage in VHR using bioresorbable mesh. We then included patients who presented with postoperative complications following VHR using P4HB mesh at Tampa General Hospital (TGH).ResultsNineteen cases of bioresorbable mesh salvage following VHR are reported in existing literature, with varying success rates. Three reported cases of mesh complication with P4HB at TGH were analyzed. The mean time to hospital presentation for postoperative complications was 37.3 days, with a median of 30 days. Complications included dehiscence (3/3 cases), infection (2/3 cases), necrosis (2/3 cases), and exposed mesh (2/3 cases). Postoperative procedures included incision and drainage (2/3 cases) and debridement (2/3 cases). Mesh salvage was successful in all cases. Complete mesh removal was not required in any case. Negative pressure wound therapy (NPWT) was utilized in all cases after wound dehiscence and complication. One patient experienced chronic diarrhea and incomplete wound closure after 12 months. There were no instances of hernia recurrence.ConclusionMesh complications are inevitable in a percentage of complex hernia repairs. Salvage of P4HB mesh in complicated VHR was successful in all reported cases at our institution.
C1 [Pharr, Trevor; Billingsley, Jenna; Docimo, Salvatore] Univ S Florida, USF Hlth Morsani Coll Med, 560 Channelside Dr, Tampa, FL 33602 USA.
   [Docimo, Salvatore] USF Hlth, Dept Gen Surg, Tampa, FL USA.
   [Docimo, Salvatore] Univ S Florida, Dept Gastrointestinal Surg, USF Hlth, Tampa, FL USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Pharr, T (通讯作者)，Univ S Florida, USF Hlth Morsani Coll Med, 560 Channelside Dr, Tampa, FL 33602 USA.
EM trevorpharr@gmail.com
OI Pharr, Trevor/0009-0001-9255-390X; Billingsley,
   Jenna/0009-0005-0431-7405
CR Ahmed A, 2024, HERNIA, V28, P575, DOI 10.1007/s10029-023-02951-4
   Al-Mansour MR, 2024, AM J SURG, V233, P100, DOI 10.1016/j.amjsurg.2024.02.028
   Christopher AN, 2021, PLAST RECONSTR SURG, V148, P1367, DOI 10.1097/PRS.0000000000008579
   Claessen JJM, 2021, HERNIA, V25, P1647, DOI 10.1007/s10029-021-02415-7
   Dickson D, 2024, COLORECTAL DIS, V26, P632, DOI 10.1111/codi.16913
   Holihan JL, 2017, SURG INFECT, V18, P647, DOI 10.1089/sur.2017.029
   Kao AM, 2018, PLAST RECONSTR SURG, V142, p149S, DOI 10.1097/PRS.0000000000004871
   Li JS, 2022, ANZ J SURG, V92, P2448, DOI 10.1111/ans.18040
   Martin DP, 2013, J SURG RES, V184, P766, DOI 10.1016/j.jss.2013.03.044
   Pauli E, 2020, INT J ABDOM WALL HER, V3, P4, DOI [10.4103/ijawhs.ijawhs_47_19, 10.4103/ijawhs.ijawhs_47_19, DOI 10.4103/IJAWHS.IJAWHS_47_19]
   Siddiqui A, 2023, J SURG RES, V291, P603, DOI 10.1016/j.jss.2023.07.003
   Smith J, 2020, Ventral Hernia
   Stremitzer S, 2010, WORLD J SURG, V34, P1702, DOI 10.1007/s00268-010-0543-z
   Warren JA, 2020, AM J SURG, V220, P751, DOI 10.1016/j.amjsurg.2020.01.028
NR 14
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD OCT 13
PY 2025
VL 29
IS 1
AR 293
DI 10.1007/s10029-025-03478-6
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8NJ2G
UT WOS:001592784000002
PM 41081958
DA 2026-07-24
ER

PT J
AU Khouqeer, A
   Uribe-Gomez, A
   Sharath, SS
   Kougias, P
   Barshes, NR
AF Khouqeer, Ahmed
   Uribe-Gomez, Alexander
   Sharath, Sherene S.
   Kougias, Panos
   Barshes, Neal R.
TI Wound Complications and Reoperations after Transtibial Amputation of the
   Leg
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID RISK-FACTORS; EXTREMITY; SURGERY; MULTICENTER; INFECTIONS; CLOSURE
AB Background: Transtibial amputations (TTAs) of the leg have been associated with high rates of wound complications. We assessed outcomes of TTAs to determine if bundled interventions implemented at our hospital had an impact on lowering wound complications, including surgical site infections.
   Methods: We assessed the impact of a surgical site infection prevention bundle (negative-pressure wound therapy, minimizing the use of staples, and a decontamination protocol for methicillin-resistant Staphylococcus aureus) on 90-day wound complications. The year of implementation of the prevention bundle was excluded, and the pre-eras and posteras were defined as the four-year period before and after implementation. The study sample consisted of a single-center cohort, with TTA cases identified using operating room scheduling software.
   Results: A total of 182 TTAs were performed: 110 in the pre-era and 72 in the postera. The wound complication rate decreased from 22 to 17% despite fewer two-stage operations, less imaging to identify peripheral artery disease, and an increased proportion of patients with end-stage renal disease. Wound complications and revision to a higher level of amputation were more associated with indication (especially no-option peripheral artery disease with ischemic rest pains) than with any particular aspect of surgical technique. The use of drains was associated with reoperations but not higher level revision.
   Conclusions: Higher rates of wound complications and revision to a higher level of amputations should be expected among patients with no-option peripheral artery disease with ischemic rest pains undergoing TTAs. Drains should be avoided.
C1 [Khouqeer, Ahmed; Sharath, Sherene S.; Kougias, Panos; Barshes, Neal R.] Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Uribe-Gomez, Alexander; Sharath, Sherene S.; Kougias, Panos; Barshes, Neal R.] Michael E DeBakey VA Med Ctr, Houston, TX USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital
RP Khouqeer, A (通讯作者)，Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Michael E Debakey Dept Surg, Div Vasc & Endovasc Surg, 2002 Holcombe Blvd,OCL 112, Houston, TX 77030 USA.
EM ahmedfk10@gmail.com
RI Sharath, Sherene/JYP-3673-2024
CR Albino FP, 2014, ARCH PLAST SURG-APS, V41, P562, DOI 10.5999/aps.2014.41.5.562
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   Nelson MT, 2012, SURGERY, V152, P685, DOI 10.1016/j.surg.2012.07.017
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NR 20
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD NOV
PY 2020
VL 69
BP 292
EP 297
DI 10.1016/j.avsg.2020.05.023
PG 6
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA TB6FL
UT WOS:000668041300036
PM 32474142
DA 2026-07-24
ER

PT J
AU Gatti, G
   Ledwon, M
   Gazdag, L
   Cuomo, F
   Pappalardo, A
   Fischlein, T
   Santarpino, G
AF Gatti, Giuseppe
   Ledwon, Miroslaw
   Gazdag, Laszlo
   Cuomo, Federica
   Pappalardo, Aniello
   Fischlein, Theodor
   Santarpino, Giuseppe
TI Management of closed sternal incision after bilateral internal thoracic
   artery grafting with a single-use negative pressure system
SO UPDATES IN SURGERY
LA English
DT Article
DE Arterial grafts; Coronary artery bypass grafting; Prevention; Quality of
   care improvement; Sternal wound infection
ID PREDICTIVE SCORING SYSTEM; WOUND THERAPY; CARDIAC-SURGERY; INFECTION;
   PERFUSION; RISK; VALIDATION; TRIAL
AB Single-use, closed incision management (CIM) systems offer a practical means of delivering negative pressure wound therapy to patients. This prospective study evaluates the Prevena Therapy system in a cohort of coronary patients at high risk of deep sternal wound infection (DSWI). Fifty-three consecutive patients undergoing bilateral internal thoracic artery (BITA) grafting were preoperatively elected for CIM with the Prevena Therapy system, which was applied immediately after surgery. The actual rate of DSWI in these patients was compared with the expected risk of DSWI according to two scoring systems specifically created to predict either DSWI after BITA grafting (Gatti score) or major infections after cardiac surgery (Fowler score). The actual rate of DSWI was lower than the expected risk of DSWI by the Gatti score (3.8 vs. 5.8%, p=0.047) but higher than by the Fowler score (2.3%, p=0.069). However, while the Gatti score showed very good calibration ((2)=4.8, p=0.69) and discriminatory power (area under the receiver-operating characteristic curve 0.838), the Fowler score showed discrete calibration ((2)=10.5, p=0.23) and low discriminatory power (area under the receiver-operating characteristic curve 0.608). Single-use CIM systems appear to be useful to reduce the risk of DSWI after BITA grafting. More studies have to be performed to make stronger this finding.
C1 [Gatti, Giuseppe; Pappalardo, Aniello] Univ Hosp Trieste, Cardiothorac & Vasc Dept, Trieste, Italy.
   [Ledwon, Miroslaw; Gazdag, Laszlo; Cuomo, Federica; Fischlein, Theodor; Santarpino, Giuseppe] Paracelsus Med Univ, Klinikum Nurnberg, Cardiovasc Ctr, Dept Cardiac Surg, Nurnberg, Germany.
   [Santarpino, Giuseppe] Citta Lecce Hosp, GVM Care & Res, Dept Cardiac Surg, Lecce, Italy.
   [Gatti, Giuseppe] Osped Cattinara, Div Cardiac Surg, Via P Valdoni 7, I-34148 Trieste, Italy.
C3 University of Trieste; University Trieste Hospital; Klinikum Nurnberg
RP Gatti, G (通讯作者)，Univ Hosp Trieste, Cardiothorac & Vasc Dept, Trieste, Italy.; Gatti, G (通讯作者)，Osped Cattinara, Div Cardiac Surg, Via P Valdoni 7, I-34148 Trieste, Italy.
EM gius.gatti@gmail.com
RI Gatti, Giuseppe/A-3849-2017; Santarpino, Giuseppe/H-8678-2013
OI Gatti, Giuseppe/0000-0002-9996-6133; Santarpino,
   Giuseppe/0000-0002-4913-9834
CR [Anonymous], 2012, EUR J CARDIOTHORACIC
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Atkins BZ, 2011, INT WOUND J, V8, P56, DOI 10.1111/j.1742-481X.2010.00743.x
   Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
   Berríos SI, 2017, JAMA SURG, V152, P784, DOI 10.1001/jamasurg.2017.0904
   Cheng K, 2015, ANN THORAC SURG, V100, P1942, DOI 10.1016/j.athoracsur.2015.06.087
   Colli A, 2011, J CARDIOTHORAC SURG, V6, DOI 10.1186/1749-8090-6-160
   Dorman MJ, 2012, CIRCULATION, V126, P2935, DOI 10.1161/CIRCULATIONAHA.112.117606
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   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
NR 22
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD DEC
PY 2018
VL 70
IS 4
BP 545
EP 552
DI 10.1007/s13304-018-0515-7
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HA5GZ
UT WOS:000450299500017
PM 29460174
DA 2026-07-24
ER

PT J
AU Ainslie-Garcia, MH
   Anderson, LA
   Bloch, BV
   Board, TN
   Chen, AF
   Craigie, S
   Danker, W 
   Gunja, N
   Harty, J
   Hernandez, VH
   Lebedeva, K
   Hameed, D
   Mont, MA
   Nunley, RM
   Parvizi, J
   Perka, C
   Piuzzi, NS
   Rolfson, O
   Rychlik, J
   Romanini, E
   Sanz-Ruiz, P
   Sierra, RJ
   Suleiman, L
   Tsiridis, E
   Vendittoli, PA
   Wangen, H
   Zagra, L
AF Ainslie-Garcia, Margaret H.
   Anderson, Lucas A.
   V. Bloch, Benjamin
   Board, Tim N.
   Chen, Antonia F.
   Craigie, Samantha
   Danker, Walter, III
   Gunja, Najmuddin
   Harty, James
   Hernandez, Victor H.
   Lebedeva, Kate
   Hameed, Daniel
   Mont, Michael A.
   Nunley, Ryan M.
   Parvizi, Javad
   Perka, Carsten
   Piuzzi, Nicolas S.
   Rolfson, Ola
   Rychlik, Joshua
   Romanini, Emilio
   Sanz-Ruiz, Pablo
   Sierra, Rafael J.
   Suleiman, Linda
   Tsiridis, Eleftherios
   Vendittoli, Pascal-Andre
   Wangen, Helge
   Zagra, Luigi
TI Identifying Critical Evidence Gaps in Wound Closure and Incision
   Management After Total Knee Arthroplasty: Delphi Panel Insights
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE wound management; total knee arthroplasty (TKA); evidence gaps; surgical
   wound closure; Delphi method; postoperative complications
ID PERIPROSTHETIC JOINT INFECTION; RISK CALCULATOR; TOTAL HIP; CONSENSUS;
   BURDEN
AB Background: Effective surgical wound management in total knee arthroplasty (TKA) is crucial for optimal healing and patient outcomes. Despite surgical advances, managing wounds to prevent complications remains challenging. This study aimed to identify and address evidence gaps in TKA wound management, including preoperative optimization, intraoperative options, and postoperative complication avoidance. Addressing these issues is vital for patient recovery and surgical success. a consensus on 26 statements about TKA wound management based on a comprehensive literature review. Additionally, the panel aimed to identify critical evidence gaps in wound management practices. Results: The panel achieved consensus on various wound management practices but highlighted significant evidence gaps. Consensus was reached on wound closure methods, including mesh-adhesive dressings, skin glue, staples, barbed sutures, and negative pressure wound therapy. However, further evidence is needed to address the cost-effectiveness of these methods and develop best practices for patient outcomes. Identifying these gaps highlights the need for more research to improve TKA wound care. Conclusions: Identifying major evidence gaps underscores the need for targeted research in TKA wound management. Addressing these gaps is crucial for developing effective, efficient, and patient-friendly wound care strategies. Future research should focus on comparative effectiveness studies and developing guidelines for emerging technologies. Bridging these gaps could improve patient outcomes, reduce complications, and enhance TKA surgery success. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Ainslie-Garcia, Margaret H.; Craigie, Samantha; Lebedeva, Kate; Rychlik, Joshua] EVERSANA, Dept Value & Evidence, Burlington, ON, Canada.
   [Anderson, Lucas A.] Univ Utah, Orthopaed Ctr, Salt Lake City, UT USA.
   [V. Bloch, Benjamin] Nottingham Univ Hosp NHS Trust, Nottingham Elect Orthopaed Serv, Hucknall Rd, Nottingham NG5 1PB, England.
   [Board, Tim N.] Wrightington Hosp, Ctr Hip Surg, Wigan, England.
   [Chen, Antonia F.] Harvard Med Sch, Brigham & WomenHospital, Dept Orthopaed Surg, Boston, MA USA.
   [Danker, Walter, III; Gunja, Najmuddin] J&J MedTech, Hlth Econ & Market Access, Raritan, NJ USA.
   [Harty, James] Cork Univ Hosp, Trauma & Orthopaed Dept, Cork, Ireland.
   [Hernandez, Victor H.] Univ Miami, Jackson Mem Hosp, Dept Orthopaed Surg & Rehabil, Miami, FL USA.
   [Hameed, Daniel; Mont, Michael A.] Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, LifeBridge Hlth, Baltimore, MD USA.
   [Nunley, Ryan M.] Washington Univ, Dept Orthopaed Surg, St. Louis, MO USA.
   [Parvizi, Javad] Thomas Jefferson Univ, Rothman Inst, Philadelphia, PA USA.
   [Perka, Carsten] Orthopad Univ Klin Charite, Ctr Muskuloskeletale Chirurg, Berlin, Germany.
   [Piuzzi, Nicolas S.] Cleveland Clin Fdn, Dept Orthoped Surg, Cleveland, OH USA.
   [Rolfson, Ola] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Orthopaed, Gothenburg, Sweden.
   [Romanini, Emilio] Polo Sanitario San Feliciano, Ctr Hip & Knee Arthroplasty, Rome, Italy.
   [Sanz-Ruiz, Pablo] Univ Complutense Madrid UCM, Fac Med, Dept Surg, Madrid, Spain.
   [Sierra, Rafael J.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Suleiman, Linda] Rush Univ, Dept Orthopaed Surg, Med Ctr, Chicago, IL USA.
   [Tsiridis, Eleftherios] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Surg, Montreal, PQ, Canada.
   [Vendittoli, Pascal-Andre] Aristotle Univ Thessaloniki, Gen Hosp Papageorgiou, Acad Orthoped Unit, Med Sch, Thessaloniki, Greece.
   [Wangen, Helge] Innlandet Hosp Trust, Dept Orthopaed Surg, Elverum, Norway.
   [Zagra, Luigi] IRCCS Ist Ortoped Galeazzi, Hip Dept, Milan, Italy.
C3 Utah System of Higher Education; University of Utah; Nottingham
   University Hospital NHS Trust; Harvard University; Harvard Medical
   School; University College Cork; University of Miami; Sinai Hospital of
   Baltimore; Washington University (WUSTL); Rothman Institute; Thomas
   Jefferson University; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Cleveland Clinic Foundation;
   University of Gothenburg; Complutense University of Madrid; Mayo Clinic;
   Rush University; Universite de Montreal; Aristotle University of
   Thessaloniki; Papageorgiou Hospital; Innlandet Hospital Trust; IRCCS
   Istituto Ortopedico Galeazzi
RP Mont, MA (通讯作者)，Sinai Hosp Baltimore, Rubin Inst Adv Orthoped, 2401 West Belvedere Ave, Baltimore, MD 21215 USA.
RI Zagra, Luigi/PFZ-1383-2026; Bloch, Benjamin/I-1041-2019; Perka,
   Carsten/ABG-6505-2021; Vendittoli, Pascal-Andre/J-9621-2013; Hernandez,
   Victor/AAG-4458-2020; /I-9296-2019; Danker III, Walter/AAP-5078-2020;
   Rolfson, Ola/AAT-2206-2020; sanz-ruiz, pablo/H-6539-2015
OI Danker III, Walter/0000-0002-9741-5821; sanz-ruiz,
   pablo/0000-0002-7588-1880
CR Ainslie-Garcia M, 2024, J ARTHROPLASTY, V39, P878, DOI 10.1016/j.arth.2023.12.032
   Beiderbeck D, 2021, METHODSX, V8, DOI 10.1016/j.mex.2021.101401
   Bozic KJ, 2013, CLIN ORTHOP RELAT R, V471, P574, DOI 10.1007/s11999-012-2605-z
   Bozic KJ, 2012, J BONE JOINT SURG AM, V94A, P794, DOI 10.2106/JBJS.K.00072
   Chen ZM, 2024, J KNEE SURG, V37, P238, DOI 10.1055/s-0043-1768248
   Chen ZM, 2022, J KNEE SURG, V35, P1524, DOI 10.1055/s-0042-1758674
   Chen Zhongming, 2022, SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, V41
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   Hasson F, 2000, J ADV NURS, V32, P1008, DOI 10.1046/j.1365-2648.2000.01567.x
   Henderson BA, 2023, CLIN OPHTHALMOL, V17, P2109, DOI 10.2147/OPTH.S412847
   Higuera-Rueda CA, 2021, J ARTHROPLASTY, V36, pS295, DOI 10.1016/j.arth.2021.02.076
   Kuhn K-D, 2017, Management of Periprosthetic Joint Infection: a global perspective on diagnosis, treatment options, prevention strategies and their economic impact
   Kurtz S, 2007, J BONE JOINT SURG AM, V89A, P780, DOI 10.2106/JBJS.F.00222
   Kurtz SM, 2012, J ARTHROPLASTY, V27, P61, DOI 10.1016/j.arth.2012.02.022
   Rothfusz CA, 2021, JBJS REV, V9, DOI 10.2106/JBJS.RVW.20.00301
   Ruiz-Tovar J, 2022, J AM COLL SURGEONS, V234, P1, DOI 10.1097/XCS.0000000000000022
   Siddiqi A, 2021, J BONE JOINT SURG AM, V103, P1335, DOI 10.2106/JBJS.20.01184
   Sodhi Nipun, 2022, SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY AND SURGICAL RESEARCH, V41
   Sundaram K, 2021, Musculoskelet Surg, V105, P275, DOI 10.1007/s12306-020-00654-y
   Sundaram K, 2020, EUR J ORTHOP SURG TR, V30, P447, DOI 10.1007/s00590-019-02591-4
   Tan TL, 2018, J BONE JOINT SURG AM, V100, P777, DOI 10.2106/JBJS.16.01435
   Tarazi JM, 2021, J KNEE SURG, V34, P1396, DOI 10.1055/s-0041-1735282
   Yoon BH, 2020, J ARTHROPLASTY, V35, P933, DOI 10.1016/j.arth.2019.11.029
   Zmistowski B, 2013, J BONE JOINT SURG AM, V95A, P1869, DOI 10.2106/JBJS.L.00679
NR 25
TC 2
Z9 3
U1 0
U2 7
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD JAN
PY 2025
VL 40
IS 1
DI 10.1016/j.arth.2024.06.057
EA NOV 2024
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA O5S8L
UT WOS:001371729300001
PM 38972434
DA 2026-07-24
ER

PT J
AU Shu, X
   Shu, SY
   Tang, SJ
   Yang, LJ
   Liu, D
   Li, K
   Dong, ZJ
   Ma, ZC
   Zhu, ZS
   Din, JL
AF Shu, Xuan
   Shu, Shenyou
   Tang, Shijie
   Yang, Lvjun
   Liu, Dan
   Li, Ke
   Dong, Zejun
   Ma, Zhongchao
   Zhu, Zhensen
   Din, Jialong
TI Efficiency of stem cell based therapy in the treatment of diabetic foot
   ulcer: a meta-analysis
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Diabetic foot ulcer; Stem cell-based therapy; Wound healing;
   Meta-analysis
ID TRANSPLANTATION; ISCHEMIA
AB Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. To assess the current evidence regarding the efficiency and potential advantages of stem cell-based therapy compared with conventional standard treatment and/or placebo in the treatment of diabetic foot ulcer. A comprehensive search in PubMed, EmBase, Cochrane Central and Web of Science databases was conducted during December 2016 and a systematic review and meta-analysis of all relevant studies were performed. A total of 7 studies that involved 224 diabetic foot patients, classified as Wagner grades 1-5, were analyzed. The pooled results confirmed the benefits of using the stem cell treatment. Partial and/or complete healing were significantly higher in the stem cell group compared with the control group (77.4% vs. 31.9%; RR: 2.22; 95% CI, 1.65-2.98). Subgroup analysis on ABI and TCP02 also confirmed the results. The present meta-analysis indicates that stem cell-based therapy can enhance the healing of diabetic foot ulcers and is associated with lesser pain, lower amputation rate and improved prognosis compared with normal treatment. Well-designed randomized controlled trials are required in the future in order to confirm and update these findings.
C1 [Shu, Xuan; Shu, Shenyou; Tang, Shijie; Liu, Dan; Li, Ke; Dong, Zejun; Zhu, Zhensen; Din, Jialong] Shantou Univ, Dept Burn & Plast Surg, Affiliated Hosp 2, Med Coll, 69 Dongxia North Rd, Shantou 515041, Peoples R China.
   [Yang, Lvjun] Shantou Univ, Translat Med Ctr, Affiliated Hosp 2, Med Coll, Shantou 515041, Peoples R China.
   [Ma, Zhongchao] Jining Med Coll, Dept Orthopaed, Jinxiang Hosp, Jining 272200, Shandong, Peoples R China.
C3 Shantou University; Shantou University; Jining Medical University
RP Shu, SY (通讯作者)，Shantou Univ, Dept Burn & Plast Surg, Affiliated Hosp 2, Med Coll, 69 Dongxia North Rd, Shantou 515041, Peoples R China.
EM syshu0328@163.com
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NR 37
TC 50
Z9 53
U1 0
U2 19
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA THE 6TH FLOOR, TAKAKURA BUILDING, 343-1, SHIJO-CHO, SHIJO
   SHINMACHI-SAGARU, SHIMOGYO-KU, KYOTO, 600-8441, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2018
VL 65
IS 4
BP 403
EP 413
DI 10.1507/endocrj.EJ17-0424
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HF6ZQ
UT WOS:000454387500003
PM 29353870
OA gold
DA 2026-07-24
ER

PT J
AU Jiang, XY
   Li, AX
   Hao, W
   Yang, C
   Wang, HY
   Deng, WQ
AF Jiang, Xiaoyan
   Li, Anxin
   Hao, Wei
   Yang, Cheng
   Wang, Hongyan
   Deng, Wuquan
TI Limb salvage and systemic management of gouty tophi: Case series
SO MEDICINE
LA English
DT Article
DE chronic refractory gout; diabetic foot ulcer; gouty tophi; limb salvage;
   negative pressure wound therapy; systemic therapy; wound healing
AB Introduction:Gout is a chronic disease characterized by deposition of monosodium urate crystals. Tophi develop in some individuals with untreated or uncontrolled gout, which leads to ulcerations, cosmetic problems, mechanical obstruction of joint movement, joint damage and musculoskeletal disability. Currently, the treatment of gouty tophi is controversial and challenging. Both surgical and internal medical treatments have limitations and require further exploration in clinical practice.Patient concerns:In Case 1, we treated a patient with severe infection of diabetic foot ulcers with concomitant multiple gouty tophi in the same limb. A systematic management strategy was formulated to close the wound and save the limb. The ulcers healed successfully after half a year. In Case 2, a giant gouty tophi located in the first metatarsophalangeal joint of the left foot was removed by surgical treatment and vancomycin-loaded bone cement implantation. In Case 3, we present a case of gouty tophi that was resolved by standardized systemic medical management.Diagnosis:Three patients were all diagnosed with gout accompanied by gouty deposition, although there were other different comorbidities.Interventions:In case 1, we used debridement to gradually remove gouty tophi. In case 2, the giant gouty tophi was removed by surgical operation. In case 3, the gouty tophi disappeared after standardized treatment with medicine, diet and lifestyle management.Outcomes:Three patients underwent different treatment therapies to remove gouty tophi based on their specific conditions.Lessons:We explored effective interventions for tophi in gout by surgical or other interventions in combination with pharmacotherapy.
C1 [Jiang, Xiaoyan; Li, Anxin; Hao, Wei; Yang, Cheng; Wang, Hongyan; Deng, Wuquan] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Metab, Chongqing 400014, Peoples R China.
C3 Chongqing University
RP Jiang, XY (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Endocrinol & Metab, Chongqing 400014, Peoples R China.
EM 545816129@qq.com; 345110926@qq.com; 28179007@qq.com; happyyangc@163.com;
   1048989208@qq.com; wuquandeng@gmail.com
OI Jiang, Xiaoyan/0000-0002-1968-6810
FU Chongqing Medical Scientific Research Project (Chongqing Health
   Commission) [2020FYYX241]; Chongqing Medical Scientific Research Project
   (Science and Technology Bureau) [2020FYYX241]
FX This study was supported by the Chongqing Medical Scientific Research
   Project (Joint Project of Chongqing Health Commission and Science and
   Technology Bureau) (Grant No.2020FYYX241) awarded to Xiaoyan Jiang.
CR Carcione J, 2021, CURR RHEUMATOL REP, V23, DOI 10.1007/s11926-020-00969-6
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NR 14
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 17
PY 2024
VL 103
IS 20
AR e38137
DI 10.1097/MD.0000000000038137
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RG7I6
UT WOS:001226575400068
PM 38758848
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Guetta, O
   Brotfain, E
   Shaked, G
   Sebbag, G
   Klein, M
   Czeiger, D
AF Guetta, Ohad
   Brotfain, Evgeni
   Shaked, Gad
   Sebbag, Gilbert
   Klein, Moti
   Czeiger, David
TI Intra-abdominal pressure may be elevated in patients with open abdomen
   after emergent laparotomy
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Abdominal compartment syndrome (ACS); Abdominal wound closure
   techniques; Intra-abdominal pressure (IAP); Intra-abdominal hypertension
   (IAH); Surgical decompression; Lactic acid
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE CONTROL; HYPERTENSION; CLOSURE
AB Purpose To estimate the change in intra-abdominal pressure (IAP) among critically ill patient who were left with open abdomen and temporary abdominal closure after laparotomy, during the first 48 h after admission. Methods A cohort study in a single ICU in a tertiary care hospital. All adult patients admitted to the ICU after emergent laparotomy for acute abdomen or trauma, who were left with temporary abdominal closure (TAC), were included. Patients were followed up to 48 h. IAP was routinely measured at 0, 6, 12, 24, and 48 h after admission to ICU. Results Thirty-nine patients were included, 34 were operated due to acute abdomen and 5 due to abdominal trauma. Seventeen patients were treated with skin closure, 13 with Bogota bag, and 9 with negative pressure wound therapy (NPWT). Eleven patients (28.2%) had IAP of 15 mmHg or above at time 0, (mean pressure 19.0 +/- 3.0 mmHg), and it dropped to 12 +/- 4 mmHg within 48 h (p < 0.01). Reduction in lactate level (2.4 +/- 1.0 to 1.2 +/- 0.2 mmol/L, p < 0.01) and increase in PaO2/FiO(2) ratio (163 +/- 34 to 231 +/- 83, p = 0.03) were observed as well after 48 h. Conclusions This is the first large report of IAP in open abdomen. Elevated IAP may be measured in open abdomen and may subsequently relieve after 48 h.
C1 [Guetta, Ohad; Sebbag, Gilbert; Czeiger, David] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Gen Surg B, Beer Sheva, Israel.
   [Brotfain, Evgeni] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Anesthesiol, Crit Care, Beer Sheva, Israel.
   [Shaked, Gad] Soroka Univ Med Ctr, Ben Gurion Univ Negev, Head Trauma Unit, Beer Sheva, Israel.
   [Klein, Moti] Ben Gurion Univ Negev, Soroka Med Ctr, Head Crit Care Dept, Gen Intens Care Unit, Beer Sheva, Israel.
C3 Ben-Gurion University of the Negev; Soroka Medical Center; Ben-Gurion
   University of the Negev; Soroka Medical Center; Ben-Gurion University of
   the Negev; Soroka Medical Center; Ben-Gurion University of the Negev;
   Soroka Medical Center
RP Guetta, O (通讯作者)，Soroka Univ Med Ctr, Ben Gurion Univ Negev, Dept Gen Surg B, Beer Sheva, Israel.
EM ohadguetta@gmail.com
RI klein, moti/AAR-6552-2021
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NR 20
TC 2
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD FEB
PY 2020
VL 405
IS 1
BP 91
EP 96
DI 10.1007/s00423-020-01854-7
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KN9IX
UT WOS:000515162200010
PM 31955259
DA 2026-07-24
ER

PT J
AU Halawi, MJ
   Morwood, MP
AF Halawi, Mohamad J.
   Morwood, Michael P.
TI Acute Management of Open Fractures: An Evidence-Based Review
SO ORTHOPEDICS
LA English
DT Article
ID TIBIAL SHAFT FRACTURES; LONG-BONE FRACTURES; PEDIATRIC POPULATION;
   ANTIBIOTIC-THERAPY; WOUND CLOSURE; INFECTION; DEBRIDEMENT; IRRIGATION;
   CLASSIFICATION; DELAY
AB Open fractures are complex injuries associated with high morbidity and mortality. Despite advances made in fracture care and infection prevention, open fractures remain a therapeutic challenge with varying levels of evidence to support some of the most commonly used practices. Additionally, a significant number of studies on this topic have focused on open tibial fractures. A systematic approach to evaluation and management should begin as soon as immediate life-threatening conditions have been stabilized. The Gustilo classification is arguably the most widely used method for characterizing open fractures. A first-generation cephalosporin should be administered as soon as possible. The optimal duration of antibiotics has not been well defined, but they should be continued for 24 hours. There is inconclusive evidence to support either extending the duration or broadening the antibiotic prophylaxis for type Gustilo type III wounds. Urgent surgical irrigation and debridement remains the mainstay of infection eradication, although questions persist regarding the optimal irrigation solution, volume, and delivery pressure. Wound sampling has a poor predictive value in determining subsequent infections. Early wound closure is recommended to minimize the risk of infection and cannot be substituted by negative-pressure wound therapy. Antibiotic-impregnated devices can be important adjuncts to systemic antibiotics in highly contaminated or comminuted injuries. Multiple fixation techniques are available, each having advantages and disadvantages. It is extremely important to maintain a high index of suspicion for compartment syndrome, especially in the setting of high-energy trauma.
C1 [Halawi, Mohamad J.; Morwood, Michael P.] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA.
C3 Duke University
RP Halawi, MJ (通讯作者)，Duke Univ, Med Ctr, Dept Orthopaed Surg, Box 3000, Durham, NC 27710 USA.
EM mohamad.halawi@dm.duke.edu
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NR 73
TC 81
Z9 108
U1 0
U2 21
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
EI 1938-2367
J9 ORTHOPEDICS
JI Orthopedics
PD NOV
PY 2015
VL 38
IS 11
BP E1025
EP E1033
DI 10.3928/01477447-20151020-12
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DA5JT
UT WOS:000367840100012
PM 26558667
DA 2026-07-24
ER

PT J
AU Robu, M
   Margarint, IM
   Draganita, A
   Guzu, M
   Iliescu, VA
AF Robu, Mircea
   Margarint, Irina Maria
   Draganita, Andrei
   Guzu, Miruna
   Iliescu, Vlad Anton
TI Antibiotic-Loaded PMMA Beads for Recurrent Sternocutaneous Fistula:
   Expanding the Surgical Armamentarium in Post-Sternotomy Osteomyelitis:
   Case Report and Literature Review
SO LIFE-BASEL
LA English
DT Review
DE sternocutaneous fistula; chronic sternal osteomyelitis; post-sternotomy
   infection; antibiotic-loaded PMMA beads; cardiac surgery complication
ID OPEN-HEART-SURGERY; 2-STAGE REVISION; CARDIAC-SURGERY; BONE-CEMENT;
   IN-VIVO; RISK-FACTORS; GENTAMICIN; INFECTIONS; MANAGEMENT; RELEASE
AB Background: Late sternocutaneous fistulas (SCFs), secondary to chronic sternal osteomyelitis, are uncommon sequelae of median sternotomy and present significant therapeutic challenges. They are frequently linked to low-virulence microorganisms forming biofilms on retained foreign materials. While antibiotic-impregnated polymethylmethacrylate (PMMA) beads are established in managing chronic osteomyelitis in other anatomical locations, reports describing their use for post-sternotomy SCFs are limited to two early postoperative cases. Case Presentation: We describe a 62-year-old man with a history of triple-vessel coronary artery disease who underwent coronary artery bypass grafting via median sternotomy. Two months postoperatively, he developed an SCF in the upper sternum, initially treated with wire removal, negative pressure wound therapy, and intravenous vancomycin. Recurrence occurred one month later without systemic signs of infection. Imaging revealed inflammatory changes at the level of the manubriosternal junction. Definitive surgery included extensive sternal and costosternal debridement, bilateral anterior arthrolysis of the second ribs, and pulse lavage with 10 L of Microdacyn. The remaining defect was filled with vancomycin- and gentamicin-loaded PMMA beads. The patient had an uneventful recovery with no recurrence at six months. Conclusions: This case suggests that local antibiotic delivery via PMMA beads can be a valuable adjunct in the surgical management of recurrent, late-presenting SCFs after cardiac surgery.
C1 [Robu, Mircea; Margarint, Irina Maria; Iliescu, Vlad Anton] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.
   [Draganita, Andrei] Giurgiu Emergency Hosp, Dept Orthoped, Giurgiu 080302, Romania.
   [Guzu, Miruna] Prof Dr CC Iliescu Emergency Inst Cardiovasc Dis, Dept Cardiac Surg, Bucharest 022328, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Margarint, IM (通讯作者)，Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.
EM mircea.robu@drd.umfcd.ro; irina-maria.margarint@drd.umfcd.ro;
   andrei.draganita@gmail.com; guzu.miruna@gmail.com; vlad.iliescu@umfcd.ro
RI Iliescu, Vlad/AAA-7692-2019; robu, mircea/IVU-7624-2023
OI robu, mircea/0000-0003-3599-129X
FU University of Medicine and Pharmacy Carol Davila through the
   institutional program Publish not Perish
FX The publication of this paper was supported by the University of
   Medicine and Pharmacy Carol Davila through the institutional program
   Publish not Perish.
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NR 55
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT 2
PY 2025
VL 15
IS 10
AR 1547
DI 10.3390/life15101547
PG 12
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 9CI3U
UT WOS:001602958000001
PM 41157220
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Thai, DQ
   Jung, YK
   Hahn, HM
   Lee, I
AF Thai, Duy Quang
   Jung, Yeon Kyo
   Hahn, Hyung Min
   Lee, Il Jae
TI Factors affecting the outcome of lower extremity osteomyelitis treated
   with microvascular free flaps: an analysis of 65 patients
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Osteomyelitis; Free flaps; Diabetic foot ulcer; Peripheral arterial
   occlusive disease
ID FREE FASCIOCUTANEOUS FLAPS; FREE-TISSUE TRANSFER; DIABETIC FOOT;
   RECONSTRUCTION; MUSCLE; DIAGNOSIS; EFFICACY; SALVAGE
AB Background Free flaps have been a useful modality in the management of lower extremity osteomyelitis particularly in limb salvage. This study aimed to determine the factors affecting the outcome of free flap reconstruction in the treatment of osteomyelitis. Methods This retrospective study assessed 65 osteomyelitis patients treated with free flap transfer from 2015 to 2020. The treatment outcomes were evaluated in terms of the flap survival rate, recurrence rate of osteomyelitis, and amputation rate. The correlation between outcomes and comorbidities, causes of osteomyelitis, and treatment modalities was analyzed. The following factors were considered: smoking, peripheral artery occlusive disease, renal disease, diabetic foot ulcer, flap types, using antibiotic beads, and negative pressure wound therapy. Result Among the 65 patients, 21 had a severe peripheral arterial occlusive disease. Osteomyelitis developed from diabetic foot ulcers in 28 patients. Total flap failure was noted in six patients, and osteomyelitis recurrence was noted in eight patients, for which two patients underwent amputation surgery during the follow-up period. Only end-stage renal disease had a significant correlation with the recurrence rate (odds ratio = 16.5, p = 0.011). There was no significant relationship between outcomes and the other factors. Conclusion This study showed that free flaps could be safely used for the treatment of osteomyelitis in patients with comorbidities and those who had osteomyelitis developing from diabetic foot ulcers. However, care should be taken in patients diagnosed with end-stage renal disease.
C1 [Thai, Duy Quang; Jung, Yeon Kyo; Hahn, Hyung Min; Lee, Il Jae] Ajou Univ, Dept Plast & Reconstruct Surg, Sch Med, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea.
   [Thai, Duy Quang] Hanoi Med Univ, Dept Plast & Reconstruct Surg, 1 Ton That Tung, Hanoi, Vietnam.
C3 Ajou University; Hanoi Medical University
RP Lee, I (通讯作者)，Ajou Univ, Dept Plast & Reconstruct Surg, Sch Med, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea.
EM i00325@live.co.kr
OI Thai, Duy Quang/0000-0002-7216-2514
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NR 26
TC 10
Z9 13
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD AUG 27
PY 2021
VL 16
IS 1
AR 535
DI 10.1186/s13018-021-02686-x
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA UI9OA
UT WOS:000690925500004
PM 34452615
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kaufman, R
   Nguyen, J
   Williams, B
   Patel, S
   Lopez, R
   Boc, SF
AF Kaufman, Richard
   Nguyen, Joshua
   Williams, Brett
   Patel, Sunny
   Lopez, Ramon
   Boc, Steven F.
TI Treatment of Traumatic Degloving Injury of the Foot Using a Biologic
   Dressing in a Pediatric Patient
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE degloving injury; trauma; foot; surgical; pediatric; dermal regeneration
   template; wound matrix; biological dressing; soft tissue damage
ID PRESSURE WOUND THERAPY; RECONSTRUCTION; MANAGEMENT; INTEGRA
AB Introduction. Degloving injuries of the foot involve the management of extensive soft tissue and osseous damage secondary to significant forced avulsion of soft tissue, which can present a major challenge for the surgeon. Surgical procedures on pediatric foot degloving involving split-thickness and/or full-thickness skin grafts and rotational flaps can result in negative consequences, such as donor site comorbidities and psychosocial implications when the pediatric patient returns to daily life. Case Report. The authors report the case of a 16-year-old girl with no past medical history who sustained an extensive degloving injury to her right foot involving severe subcutaneous and muscular soft tissue disruption and contamination. The initial treatment consisted of debridement, copious irrigation, primary wound closure at several sites, and application of an extracellular matrix (ECM) substitute graft. Shortly thereafter, secondary treatment consisted of application of primary musculoskeletal repair, negative pressure wound therapy (NPWT), and application of a dermal regeneration template. Over the 5-month course of treatment, an additional 3 trips to the operating room occurred, involving serial irrigation and debridement, NPWT application, and dermal/ECM substitute graft applications, leading to full epithelialization. Conclusions. To the best of the authors knowledge, this is the first reported case in which an instance of pediatric foot degloving is presented with serial debridement, NPWT, and biological dressings, resulting in no additional plastic surgical techniques needed to provide return to functional outcome.
C1 [Kaufman, Richard] Ankle & Foot Ctr Georgia, 865 Holcomb Bridge, Roswell, GA 30076 USA.
   [Kaufman, Richard] Piedmont Atlanta Hosp, Atlanta, GA USA.
   [Nguyen, Joshua] Rosalind Franklin Univ Med & Sci, Dr William M Scholl Coll Podiatr Med, N Chicago, IL USA.
   [Williams, Brett] Foot & Ankle Ctr Philadelphia, Philadelphia, PA USA.
   [Patel, Sunny] Achilles Foot & Ankle Ctr, Henrico, VA USA.
   [Lopez, Ramon; Boc, Steven F.] Hahnemann Univ Hosp DUCOM, Philadelphia, PA USA.
C3 Rosalind Franklin University of Medicine & Science
RP Kaufman, R (通讯作者)，Ankle & Foot Ctr Georgia, 865 Holcomb Bridge, Roswell, GA 30076 USA.
EM kaufmandpm@ankleandfootcenters.com
RI Kaufman, Richard/E-8890-2018; /AAJ-6188-2021
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NR 23
TC 4
Z9 5
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2019
VL 31
IS 11
BP E77
EP E81
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KU5IM
UT WOS:000519743900002
PM 31876514
DA 2026-07-24
ER

PT J
AU Chakraborty, R
   Borah, P
   Dutta, PP
   Sen, S
AF Chakraborty, Raja
   Borah, Pobitra
   Dutta, Partha Pratim
   Sen, Saikat
TI Evolving spectrum of diabetic wound: Mechanistic insights and
   therapeutic targets
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetic Wound; Diabetic Foot Ulcer; Epigenetic mechanisms; Therapeutic
   agents; Molecular Targets; Phytoconstituents
ID FIBROBLAST-GROWTH-FACTOR; MESENCHYMAL STROMAL CELLS; CHRONIC FOOT
   ULCERS; MATRIX-METALLOPROTEINASES; DOUBLE-BLIND; DECREASED EXPRESSION;
   DNA METHYLATION; LOWER-EXTREMITY; OXYGEN-THERAPY; MAST-CELLS
AB Diabetes mellitus is a chronic metabolic disorder resulting in an increased blood glucose level and prolonged hyperglycemia, causes long term health conse-quences. Chronic wound is frequently occurring in diabetes patients due to compromised wound healing capability. Management of wounds in diabetic patients remains a clinical challenge despite many advancements in the field of science and technology. Increasing evidence indicates that alteration of the biochemical milieu resulting from alteration in inflammatory cytokines and matrix metalloproteinase, decrease in fibroblast and keratinocyte functioning, neuropathy, altered leukocyte functioning, infection, etc., plays a significant role in impaired wound healing in diabetic people. Apart from the current pharmacotherapy, different other approaches like the use of conventional drugs, antidiabetic medication, antibiotics, debridement, offloading, platelet-rich plasma, growth factor, oxygen therapy, negative pressure wound therapy, low-level laser, extracorporeal shock wave bioengineered substitute can be considered in the management of diabetic wounds. Drugs/therapeutic strategy that induce angiogenesis and collagen synthesis, inhibition of MMPs, reduction of oxidative stress, controlling hyperglycemia, increase growth factors, regulate inflammatory cytokines, cause NO induction, induce fibroblast and keratinocyte proliferation, control microbial infections are considered important in controlling diabetic wound. Further, medicinal plants and/or phytoconstituents also offer a viable alternative in the treatment of diabetic wound. The focus of the present review is to highlight the molecular and cellular mechanisms, and discuss the drug targets and treatment strategies involved in the diabetic wound.
C1 [Chakraborty, Raja] Assam Don Bosco Univ, Inst Pharm, Kamrup 782402, Assam, India.
   [Borah, Pobitra] Graphic Era Hill Univ, Sch Pharm, Dehra Dun 248002, Uttaranchal, India.
   [Dutta, Partha Pratim; Sen, Saikat] Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
C3 Assam Don Bosco University
RP Sen, S (通讯作者)，Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
EM saikat.pharm@rediffmail.com
RI Dutta, Partha Pratim/KHE-5018-2024; Sen, Saikat/E-8091-2011;
   Chakraborty, Raja/E-1077-2012; /AAQ-7302-2021
OI Dutta, Partha Pratim/0000-0003-0907-3030; Sen,
   Saikat/0000-0002-5279-1532; Chakraborty, Raja/0000-0002-2097-9178; 
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NR 180
TC 53
Z9 57
U1 4
U2 67
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD SEP 15
PY 2022
VL 13
IS 9
BP 696
EP 716
DI 10.4239/wjd.v13.i9.696
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5F3PF
UT WOS:000866230300003
PM 36188143
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Gillespie, BM
   Webster, J
   Ellwood, D
   Stapleton, H
   Whitty, JA
   Thalib, L
   Cullum, N
   Mahomed, K
   Chaboyer, W
AF Gillespie, Brigid M.
   Webster, Joan
   Ellwood, David
   Stapleton, Helen
   Whitty, Jennifer A.
   Thalib, Lukman
   Cullum, Nicky
   Mahomed, Kassam
   Chaboyer, Wendy
TI ADding negative pRESSure to improve healING (the DRESSING trial): a RCT
   protocol
SO BMJ OPEN
LA English
DT Article
ID SURGICAL SITE INFECTION; WOUND THERAPY; PREVALENCE SURVEY; HEALTH;
   COMPLICATIONS; OBESITY; IMPACT
AB Introduction: Obese women are more likely to develop a surgical site infection (SSI) following caesarean section (CS) than non-obese women. Negative pressure wound therapy (NPWT) is increasingly being used to reduce SSI with limited evidence for its effectiveness.
   Objectives: To determine the clinical and cost-effectiveness of using NPWT in obese women having elective and semiurgent CS.
   Methods and analysis: A multisite, superiority parallel pragmatic randomised controlled trial with an economic evaluation. Women with a body mass index (BMI) of >= 30, booked for elective and semiurgent CS at 4 Australian acute care hospitals will be targeted. A total of 2090 women will be enrolled. A centralised randomisation service will be used with participants block randomised to either NPWT or standard surgical dressings in a 1:1 ratio, stratified by hospital. The primary outcome is SSI; secondary outcomes include type of SSI, length of stay, readmission, wound complications and health-related quality of life. Economic outcomes include direct healthcare costs and cost-effectiveness, which will be evaluated using incremental cost per quality-adjusted life year gained. Data will be collected at baseline, and participants followed up on the second postoperative day and weekly from the day of surgery for 4 weeks. Outcome assessors will be masked to allocation. The primary statistical analysis will be based on intention-to-treat.
   Ethics and dissemination: Ethics approval has been obtained from the ethics committees of the participating hospitals and universities. The findings of the trial will be disseminated through peer-reviewed journals, national and international conference presentations.
C1 [Gillespie, Brigid M.] Griffith Univ, NHMRC Ctr Res Excellence Nursing, Ctr Hlth Practice Innovat HPI, Menzies Hlth Inst Qld, Gold Coast, Qld, Australia.
   [Webster, Joan] Royal Brisbane & Womens Hosp, Res Ctr Clin Nursing, Nathan, Qld, Australia.
   [Webster, Joan] Griffith Univ, Nathan, Qld, Australia.
   [Ellwood, David] Griffith Univ, Sch Med, Dept Obstet & Gynaecol, Nathan, Qld 4111, Australia.
   [Ellwood, David] Gold Coast Univ Hosp, Maternal Fetal Med, Southport, Qld, Australia.
   [Stapleton, Helen] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Whitty, Jennifer A.] Univ Queensland, Dept Hlth Econ Pharmacoecon & Qual Use Med, Sch Pharm, Brisbane, Qld, Australia.
   [Thalib, Lukman] Qatar Univ, Dept Hlth Sci, Coll Arts & Sci, Doha, Qatar.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Mahomed, Kassam] West Moreton Hosp & Hlth Serv, Ipswich, Qld, Australia.
   [Chaboyer, Wendy] Griffith Univ, Menzies Hlth Inst Qld, NHMRC Ctr Res Excellence Nursing, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; Royal Brisbane
   & Women's Hospital; Griffith University; Griffith University; Gold Coast
   University Hospital; University of Queensland; Mater Research;
   University of Queensland; Qatar University; University of Manchester;
   Menzies Health Institute Queensland; Griffith University
RP Gillespie, BM (通讯作者)，Griffith Univ, NHMRC Ctr Res Excellence Nursing, Ctr Hlth Practice Innovat HPI, Menzies Hlth Inst Qld, Gold Coast, Qld, Australia.
EM b.gillespie@griffith.edu.au
RI Whitty, Jennifer/N-6434-2013; Chaboyer, Wendy/F-9588-2018; Cullum,
   Nicky/F-2438-2011; Ellwood, David/C-8208-2015; Thalib,
   Lukman/HAI-7553-2022; Gillespie, Brigid/E-7799-2012; Mahomed,
   Kassam/M-1335-2013
OI Chaboyer, Wendy/0000-0001-9528-7814; Cullum, Nicky/0000-0003-2631-123X;
   Ellwood, David/0000-0003-4512-6443; Thalib, Lukman/0000-0002-1211-6495;
   Gillespie, Brigid/0000-0003-3186-5691; 
FU Australian National Health & Medical Research Project Grant [APP1081026]
FX This trial is funded through an Australian National Health & Medical
   Research Project Grant (APP1081026).
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PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 2
AR e010287
DI 10.1136/bmjopen-2015-010287
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT5HX
UT WOS:000381514500113
PM 26832435
OA Green Accepted, Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Jiang, MY
   Wang, XJ
   Wu, YJ
   Xiao, YR
   Xiao, Q
   Xiong, J
   Shang, WW
AF Jiang, Mengyao
   Wang, Xuejun
   Wu, Yujie
   Xiao, Yaru
   Xiao, Qi
   Xiong, Jie
   Shang, Weiwei
TI Low-value clinical practices in pressure injury management: a scoping
   review
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Review
DE Pressure injury; Low-value care; Value-based care; Scoping review;
   Nursing
ID CARE; PREVENTION; STRATEGIES; COST
AB Background Low-value care (LVC) is increasingly recognized as a contributor to inefficiency in healthcare. Pressure injury (PI) is a key nursing-sensitive quality indicator and involve numerous interventions. However, to date, no studies have systematically identified which practices qualify as low-value. This scoping review aims to synthesize existing evidence on LVC in PI management to inform research priorities and clinical improvements. Method We conducted a comprehensive search of PubMed, Embase, Web of Science, CINAHL, CNKI, Wanfang, VIP, and CBM databases up to December 10, 2024, to identify eligible articles. Two reviewers independently screened the abstracts and full texts, with conflicts resolved through discussion until consensus was reached. Data were extracted using a piloted data-charting form. Results Of the 1884 publications screened, 25 met the inclusion criteria. The focus areas of the included articles included PI prevention (n = 13), PI treatment (n = 10), and both prevention and treatment (n = 2). The identified low-value care targets were diverse. They included unrestricted practices (n = 6), dressings and topical agents (n = 4), repositioning (n = 3), support surfaces (n = 3), education (n = 2), risk assessment tools (n = 1), nutritional intervention (n = 1), electrical stimulation (n = 1), negative pressure wound therapy (n = 1), phototherapy (n = 1), electromagnetic therapy (n = 1), and therapeutic ultrasound (n = 1). Conclusions This scoping review found that some progress has been made in identifying low-value practices in PI management. However, significant gaps remain. Future research should focus on generating high-quality evidence and incorporating patient preferences to address these gaps.
C1 [Jiang, Mengyao; Wang, Xuejun; Wu, Yujie; Xiao, Yaru; Xiao, Qi; Xiong, Jie; Shang, Weiwei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nursing, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Jiang, Mengyao; Xiao, Qi; Xiong, Jie; Shang, Weiwei] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Crit Care Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Wang, Xuejun] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Tradit Chinese Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
   [Wu, Yujie; Xiao, Yaru] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Emergency Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Shang, WW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nursing, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.; Shang, WW (通讯作者)，Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Crit Care Med, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China.
EM jiangmengyao0516@163.com; 2458132465@qq.com; 2254178085@qq.com;
   178706345@qq.com; 68186187@qq.com; 914808880@qq.com; 55329463@qq.com
FU Nursing Research Special Fund Project of Tongji Hospital
FX We would like to thank Kaiyan Hu for her assistance.
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NR 58
TC 0
Z9 0
U1 5
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD OCT 8
PY 2025
VL 25
IS 1
AR 1327
DI 10.1186/s12913-025-13519-6
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA 8KR6P
UT WOS:001590965500007
PM 41063148
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wu, MF
   Matar, DY
   Yu, Z
   Chen, ZY
   Knoedler, S
   Ng, B
   Darwish, OA
   Sohrabi, S
   Friedman, L
   Haug, V
   Murphy, GF
   Rinkevich, Y
   Orgill, DP
   Panayi, AC
AF Wu, Mengfan
   Matar, Dany Y.
   Yu, Zhen
   Chen, Ziyu
   Knoedler, Samuel
   Ng, Brian
   Darwish, Oliver A.
   Sohrabi, Sadaf
   Friedman, Leigh
   Haug, Valentin
   Murphy, George F.
   Rinkevich, Yuval
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Continuous NPWT Regulates Fibrosis in Murine Diabetic Wound Healing
SO PHARMACEUTICS
LA English
DT Article
DE wound healing; fibrosis; scarring; NPWT; mechanotransduction; YAP;
   tissue regeneration; caspase3
ID NEGATIVE-PRESSURE THERAPY; CELL-PROLIFERATION; HYPERTROPHIC SCARS;
   SURGICAL WOUNDS; SKIN; TRANSITION; MANAGEMENT; EXPRESSION; PROTEIN;
   APOPTOSIS
AB Scarring is associated with significant morbidity. The mechanical signaling factor yes-associated protein (YAP) has been linked to Engrailed-1 (En1)-lineage positive fibroblasts (EPFs), a pro-scarring fibroblast lineage, establishing a connection between mechanotransduction and fibrosis. In this study, we investigate the impact of micromechanical forces exerted through negative pressure wound therapy (NPWT) on the pathophysiology of fibrosis. Full-thickness excisional dorsal skin wounds were created on diabetic (db/db) mice which were treated with occlusive covering (control) or NPWT (continuous, -125 mmHg, 7 days; NPWT). Analysis was performed on tissue harvested 10 days after wounding. NPWT was associated with increased YAP (p = 0.04) but decreased En1 (p = 0.0001) and CD26 (p < 0.0001). The pro-fibrotic factors Vimentin (p = 0.04), alpha-SMA (p = 0.04) and HSP47 (p = 0.0008) were decreased with NPWT. Fibronectin was higher (p = 0.01) and collagen deposition lower in the NPWT group (p = 0.02). NPWT increased cellular proliferation (p = 0.002) and decreased apoptosis (p = 0.03). Western blotting demonstrated increased YAP (p = 0.02) and RhoA (p = 0.03) and decreased Caspase-3 (p = 0.03) with NPWT. NPWT uncouples YAP from EPF activation, through downregulation of Caspace-3, a pro-apoptotic factor linked to keloid formation. Mechanotransduction decreases multiple pro-fibrotic factors. Through this multifactorial process, NPWT significantly decreases fibrosis and offers promising potential as a mode to improve scar appearance.
C1 [Wu, Mengfan] Peking Univ Shenzhen Hosp, Dept Plast Surg, Shenzhen 518036, Peoples R China.
   [Wu, Mengfan; Matar, Dany Y.; Chen, Ziyu; Knoedler, Samuel; Ng, Brian; Darwish, Oliver A.; Friedman, Leigh; Haug, Valentin; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.
   [Matar, Dany Y.] Washington Univ, Sch Med, St Louis, MO 63110 USA.
   [Yu, Zhen] Jinan Univ, Shenzhen Eye Hosp, Dept Ophthalmol, Shenzhen Key Ophthalm Lab, Shenzhen 518040, Peoples R China.
   [Yu, Zhen] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Dept Ophthalmol, Angiogenesis Lab, Boston, MA 02114 USA.
   [Knoedler, Samuel] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Ng, Brian] St Louis Univ, Sch Med, St Louis, MO 63104 USA.
   [Darwish, Oliver A.] Calif Northstate Univ, Sch Med, Elk Grove, CA 95757 USA.
   [Sohrabi, Sadaf; Murphy, George F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Div Dermatopathol, Boston, MA 02115 USA.
   [Friedman, Leigh] Lehigh Univ, Dept Med, Bethlehem, PA 18015 USA.
   [Friedman, Leigh] Drexel Univ, Sch Med, Philadelphia, PA 19129 USA.
   [Haug, Valentin; Panayi, Adriana C.] Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, D-67071 Ludwigshafen, Germany.
   [Rinkevich, Yuval] Helmholtz Zentrum Munchen, Sch Med, Inst Regenerat Biol & Med, D-81377 Munich, Germany.
C3 Peking University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School;
   Washington University (WUSTL); Jinan University; Shenzhen Eye Hospital;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts Eye & Ear Infirmary; Technical University of
   Munich; Saint Louis University; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Lehigh University; Drexel University; Ruprecht Karls
   University Heidelberg; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health
RP Panayi, AC (通讯作者)，Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA.; Panayi, AC (通讯作者)，Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, D-67071 Ludwigshafen, Germany.
EM a.panayi@cantab.net
RI ; Haug, Valentin/ADF-7566-2022; Knoedler, Samuel Alfons/IZQ-4210-2023;
   Orgill, Dennis/H-7596-2019; Panayi, Adriana/HHT-0513-2022
OI Chen, Ziyu/0000-0001-5562-7554; Knoedler, Samuel
   Alfons/0000-0001-5798-8003; Matar, Dany/0000-0001-7108-0413; Friedman,
   Leigh/0000-0002-4047-7896; Wu, Mengfan/0000-0003-2646-3372; Panayi,
   Adriana/0000-0003-4053-9855; Yu, Zhen/0000-0003-3456-3584
FU Gillian Reny Stepping Strong Center for Trauma Innovation; 3M*KCI
   (Kinetic Concepts Inc.); UK-US Fulbright commission; NIH [5 T35
   HL11084]; Natural Science Foundation from Shenzhen Science and
   Technology Innovation Commission [20210319172905002]; Shenzhen Key
   Medical Discipline Construction Fund [SZXK026]; European Research
   Council [819933]; LEO Foundation [LF-OC-21-000835]; European Foundation
   for the Study of Diabetes (EFSD) Anniversary Fund Programme; European
   Research Council (ERC) [819933] Funding Source: European Research
   Council (ERC)
FX This work was funded by The Gillian Reny Stepping Strong Center for
   Trauma Innovation and 3M*KCI (Kinetic Concepts Inc.). S.S. was funded by
   the UK-US Fulbright commission with an All Disciplines Award. L.F. was
   funded by the NIH 5 T35 HL11084 fellowship award. M.W. was supported by
   the Natural Science Foundation from Shenzhen Science and Technology
   Innovation Commission(20210319172905002) and the Shenzhen Key Medical
   Discipline Construction Fund (No.SZXK026). Y.R. was supported by the
   European Research Council Consolidator Grant (ERC-CoG 819933), the LEO
   Foundation (LF-OC-21-000835) and the European Foundation for the Study
   of Diabetes (EFSD) Anniversary Fund Programme.
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NR 48
TC 15
Z9 17
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD OCT
PY 2022
VL 14
IS 10
AR 2125
DI 10.3390/pharmaceutics14102125
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5Q4OF
UT WOS:000873812500001
PM 36297560
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sawada, T
   Asai, J
   Nomiyama, T
   Masuda, K
   Takenaka, H
   Katoh, N
AF Sawada, Takahiro
   Asai, Jun
   Nomiyama, Tomoko
   Masuda, Koji
   Takenaka, Hideya
   Katoh, Norito
TI Trigeminal trophic syndrome: Report of a case and review of the
   published work
SO JOURNAL OF DERMATOLOGY
LA English
DT Review
DE craniotomy; review; therapeutics; trigeminal nerve injuries; trigeminal
   trophic syndrome
AB Trigeminal trophic syndrome is a rare complication of trigeminal nerve injury that causes facial ulceration, anesthesia and paresthesia in the same trigeminal dermatomes. We present a case of a 65-year-old woman with a history of meningioma resection 18 years prior who presented 16 years later with an intractable ulceration around her left nasolabial sulcus. Pain and light-touch sensations around the ulcer were decreased. She admitted to frequent manipulation due to a crawling sensation. A skin biopsy showed acanthotic changes and a decreased number of peripheral nerve fibers. Trigeminal trophic syndrome was diagnosed. Carbamazepine was not effective, and the ulcer persisted at 7 months after the initial presentation. We reviewed 36 English-language publications from 2003 to 2012, and analyzed 61 cases of trigeminal trophic syndrome, including this patient. The mean age was 53.3 +/- 19.7 years (range, 6-91). The right side of the face was more commonly affected (57%) than the left side. The ala nasi were involved in 48 cases (79%), followed by the cheek in 17 cases (28%). A corneal lesion was observed in 11 cases (18%), suggesting the importance of ophthalmologic consultations. The two major etiologies were trigeminal nerve ablation (18 cases; 30%) and cerebrovascular accidents (18 cases; 30%). The latent period ranged from days to 30 years. Gabapentin and carbamazepine were frequently administrated with variable efficacy. Application of thermoplastic dressings or negative pressure wound therapy demonstrated favorable outcomes. Surgery was an option with a high recurrence rate. Trigeminal trophic syndrome remains a clinical challenge.
C1 [Sawada, Takahiro; Asai, Jun; Nomiyama, Tomoko; Masuda, Koji; Takenaka, Hideya; Katoh, Norito] Kyoto Prefectural Univ Med, Dept Dermatol, Kyoto 6028566, Japan.
C3 Kyoto Prefectural University of Medicine
RP Sawada, T (通讯作者)，Kyoto Prefectural Univ Med, Dept Dermatol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM tasawa@koto.kpu-m.ac.jp
RI Asai, Jun/AAD-4796-2020
OI Asai, Jun/0000-0002-7610-0820
CR Fredeking AE, 2008, ARCH DERMATOL, V144, P984, DOI 10.1001/archderm.144.8.984
   Frühauf J, 2008, MAYO CLIN PROC, V83, P502, DOI 10.4065/83.4.502
   Garza I, 2008, CEPHALALGIA, V28, P980, DOI 10.1111/j.1468-2982.2008.01636.x
   Luksic I, 2008, J NEUROSURG, V108, P170, DOI 10.3171/JNS/2008/108/01/0170
   Mishra SN, 2011, INDIAN J DERMATOL VE, V77, DOI 10.4103/0378-6323.86501
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   Pedicelli C, 2009, INT J DERMATOL, V48, P443, DOI 10.1111/j.1365-4632.2009.03920.x
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   Rashid RM, 2007, J EUR ACAD DERMATOL, V21, P725, DOI 10.1111/j.1468-3083.2007.02250.x
   Sadeghi P, 2004, DERMATOL SURG, V30, P807, DOI 10.1111/j.1524-4725.2004.30220.x
   Setyadi HG, 2007, SOUTH MED J, V100, P43, DOI 10.1097/01.smj.0000253020.74133.7e
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   Wallengren J, 2002, J AM ACAD DERMATOL, V46, P215, DOI 10.1067/mjd.2002.118540
   Walling HW, 2009, J AM ACAD DERMATOL, V61, P160, DOI 10.1016/j.jaad.2008.11.909
   WEINTRAUB E, 1982, J AM ACAD DERMATOL, V6, P52, DOI 10.1016/S0190-9622(82)80200-4
NR 15
TC 41
Z9 45
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD JUN
PY 2014
VL 41
IS 6
BP 525
EP 528
DI 10.1111/1346-8138.12490
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AJ4ZK
UT WOS:000337689100009
PM 24807466
DA 2026-07-24
ER

PT J
AU Hickson, E
   Harris, J
   Brett, D
AF Hickson, Evelyn
   Harris, Jeanette
   Brett, David
TI A Journey to Zero: Reduction of Post-Operative Cesarean Surgical Site
   Infections over a Five-Year Period
SO SURGICAL INFECTIONS
LA English
DT Article
ID PRESSURE WOUND THERAPY; MANAGEMENT
AB Background: Surgical site infections (SSI) are a substantial concern for cesarean deliveries in which a surgical site complication is most unwelcome for a mother with a new infant. Steps taken pre- and post-operatively to reduce the number of complications may be of substantial benefit clinically, economically, and psychologically.
   Methods: A risk-based approach to incision management was developed and implemented for all cesarean deliveries at our institution. A number of incremental interventions for low-risk and high-risk patients including pre-operative skin preparations, standardized pre- and post-operative protocols, post-operative nanocrystalline silver anti-microbial barrier dressings, and incisional negative pressure wound therapy (NPWT) were implemented sequentially over a 5-y period. A systematic clinical chart review of 4,942 patients spanning all cesarean deliveries between 2007-2012 was performed to determine what effects the interventions had on the rate of SSI for cesarean deliveries.
   Results: The percentage of SSI was reduced from 2.13% (2007) to 0.10% (2012) (p<0.0001). There were no substantial changes in the patient population risk factors over this time. As a result of the changes in incision management practice, a total of 92 cesarean post-operative SSIs were avoided: A total cost saving of nearly $5,000,000.
   Conclusion: Applying a clinical algorithm for assessing the risk of surgical site complication and making recommendations on pre-operative and post-operative incision management can result in a substantial and sustainable reduction in cesarean SSI.
C1 [Hickson, Evelyn] MultiCare Hlth Syst, Puyallup, WA USA.
   [Harris, Jeanette] MultiCare Hlth Syst, Infect Prevent, Puyallup, WA USA.
   [Brett, David] Smith & Nephew Wound Management Div, St Petersburg, FL 33701 USA.
C3 Smith & Nephew
RP Brett, D (通讯作者)，Smith & Nephew Wound Management Div, St Petersburg, FL 33701 USA.
EM dave.brett@smith-nephew.com
OI Harris, Jeanette/0000-0002-9871-2764
FU Smith Nephew
FX E.H. has acted as a consultant for a fee and been paid or sponsored by
   the organization (Smith & Nephew) to speak to professional or lay
   groups. J.H. has been paid or sponsored by the organization (Smith &
   Nephew) to speak to professional or lay groups. D.B. is an employee and
   a shareholder of Smith & Nephew, Inc.
CR Basha SL, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.07.011
   Childress BB, 2007, ANN VASC SURG, V21, P598, DOI 10.1016/j.avsg.2007.03.024
   Connery SA, 2012, ADV SKIN WOUND CARE, V25, P414, DOI 10.1097/01.ASW.0000419407.37323.e8
   Dumville JC, 2013, COCHRANE DB SYST REV, V3, P1
   Edwards JR, 2009, AM J INFECT CONTROL, V37, P783, DOI 10.1016/j.ajic.2009.10.001
   Gomoll AH, 2006, J ORTHOP TRAUMA, V20, P705, DOI 10.1097/01.bot.0000211159.98239.d2
   Hudson DA, 2013, INT WOUND J, V1, P1
   Karlakki S, 2013, BONE JOINT RES, V2, P276, DOI 10.1302/2046-3758.212.2000190
   Krieger BR, 2011, DIS COLON RECTUM, V54, P1014, DOI 10.1097/DCR.0b013e31821c495d
   Mark KS, 2013, SURG INNOV, V21, P1
   Menacker F, 2010, NCHS DATA BRIEF, P1
   Olsen MA, 2010, INFECT CONT HOSP EP, V31, P276, DOI 10.1086/650755
   Sarsam SE, 2005, OBSTET GYNECOL SURV, V60, P462, DOI 10.1097/01.ogx.0000166603.43959.aa
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Wloch C, 2012, BJOG-INT J OBSTET GY, V119, P1324, DOI 10.1111/j.1471-0528.2012.03452.x
NR 15
TC 24
Z9 25
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR 1
PY 2015
VL 16
IS 2
BP 174
EP 177
DI 10.1089/sur.2014.145
PG 4
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA CF2EN
UT WOS:000352360400011
PM 25826622
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU González-Hadad, A
   Ordoñez, CA
   Parra, MW
   Caicedo, Y
   Padilla, N
   Millán, M
   García, A
   Vidal-Carpio, JM
   Pino, LF
   Herrera, MA
   Quintero, L
   Hernández, F
   Flórez, G
   Rodríguez-Holguín, F
   Salcedo, A
   Serna, JJ
   Franco, MJ
   Ferrada, R
   Navsaria, PH
AF Gonzalez-Hadad, Adolfo
   Ordonez, Carlos A.
   Parra, Michael W.
   Caicedo, Yaset
   Padilla, Natalia
   Millan, Mauricio
   Garcia, Alberto
   Vidal-Carpio, Jenny Marcela
   Pino, Luis Fernando
   Herrera, Mario Alain
   Quintero, Laureano
   Hernandez, Fabian
   Florez, Guillermo
   Rodriguez-Holguin, Fernando
   Salcedo, Alexander
   Serna, Jose Julian
   Franco, Maria Josefa
   Ferrada, Ricardo
   Navsaria, Pradeep H.
TI Damage control in penetrating cardiac trauma
SO COLOMBIA MEDICA
LA English
DT Review
DE Thoracic Ultrasound; Damage Control Surgery; Penetrating cardiac trauma;
   cardiac tamponade; thoracotomy; advanced trauma life support care;
   negative-pressure wound therapy; sternotomy; pericardiectomy; death,
   sudden; hemothora; chest tubes; pneumothorax; pericardial window
   techniques
ID ULTRASOUND; MANAGEMENT; INJURIES
AB Definitive management of hemodynamically stable patients with penetrating cardiac injuries remains controversial between those who propose aggressive invasive care versus those who opt for a less invasive or non-operative approach. This controversy even extends to cases of hemodynamically unstable patients in which damage control surgery is thought to be useful and effective. The aim of this article is to delineate our experience in the surgical management of penetrating cardiac injuries via the creation of a clear and practical algorithm that includes basic principles of damage control surgery. We recommend that all patients with precordial penetrating injuries undergo trans-thoracic ultrasound screening as an integral component of their initial evaluation. In those patients who arrive hemodynamically stable but have a positive ultrasound, a pericardial window with lavage and drainage should follow. We want to emphasize the importance of the pericardial lavage and drainage in the surgical management algorithm of these patients. Before this concept, all positive pericardial windows ended up in an open chest exploration. With the coming of the pericardial lavage and drainage procedure, the reported literature and our experience have shown that 25% of positive pericardial windows do not benefit and/or require further invasive procedures. However, in hemodynamically unstable patients, damage control surgery may still be required to control ongoing bleeding. For this purpose, we propose a surgical management algorithm that includes all of these essential clinical aspects in the care of these patients.
C1 [Gonzalez-Hadad, Adolfo; Ordonez, Carlos A.; Garcia, Alberto; Pino, Luis Fernando; Herrera, Mario Alain; Quintero, Laureano; Hernandez, Fabian; Florez, Guillermo; Salcedo, Alexander; Serna, Jose Julian] Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Pino, Luis Fernando; Herrera, Mario Alain; Hernandez, Fabian; Salcedo, Alexander; Serna, Jose Julian; Ferrada, Ricardo] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Quintero, Laureano; Ferrada, Ricardo] Ctr Med Imbanaco, Cali, Colombia.
   [Ordonez, Carlos A.; Garcia, Alberto; Rodriguez-Holguin, Fernando; Salcedo, Alexander; Serna, Jose Julian; Franco, Maria Josefa] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Millan, Mauricio; Garcia, Alberto; Salcedo, Alexander; Serna, Jose Julian] Univ Icesi, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Millan, Mauricio] Fdn Valle Lili, Div Transplant Surg, Dept Surg, Cali, Colombia.
   [Vidal-Carpio, Jenny Marcela] Hosp Gen Teofilo Davila, Serv Emergencias, Cuenca, Ecuador.
   [Vidal-Carpio, Jenny Marcela] Univ Cuenca, Dept Surg, Cuenca, Ecuador.
   [Navsaria, Pradeep H.] Univ Cape Town, Groote Schuur Hosp, Fac Hlth Sci, Trauma Ctr, Anzio Rd, Cape Town, South Africa.
C3 Universidad del Valle; Universidad del Valle; Fundacion Valle del Lili;
   Universidad ICESI; Fundacion Valle del Lili; Fundacion Valle del Lili;
   Universidad de Cuenca; University of Cape Town
RP Ordoñez, CA (通讯作者)，Univ Valle, Fac Salud, Escuela Med, Dept Surg,Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
EM ordonezcarlosa@gmail.com
RI Herrera, Mario Alain/LRB-9290-2024; Navsaria, Pradeep/AAS-1807-2020
OI Herrera, Mario Alain/0000-0002-4526-7636; Navsaria,
   Pradeep/0000-0002-5152-3317; Padilla-Londoño,
   Natalia/0000-0003-3292-6919; PINO OLIVEROS, LUIS
   FERNANDO/0000-0002-1179-2854
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   Garcia A., 2019, REV COLOMB CIRUGIA, V34, P16, DOI [10.30944/20117582.93., DOI 10.30944/20117582.93]
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NR 25
TC 8
Z9 13
U1 0
U2 4
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2021
VL 52
IS 2
AR e4034519
DI 10.25100/cm.v52i2.4519
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RZ9EA
UT WOS:000648900100003
PM 34188321
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Agosti, JK
   Chandler, LA
   Anderton, CM
   Clark, RM
AF Agosti, Jennifer K.
   Chandler, Lois A.
   Anderton, Caryn M.
   Clark, Rita M.
TI Serial Sharp Debridement and Formulated Collagen Gel to Treat Pressure
   Ulcers in Elderly Long-term Care Patients: A Case Study
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case study; pressure ulcer; long-term care; debridement; collagen
ID CONTROLLED-TRIAL; PILOT
AB Clinicians treating pressure ulcers in the elderly in long-term care often face psychosocial, financial, and patient quality-of-life challenges; as such, they seek to identify products that meet wound healing goals as expeditiously as possible. The purpose of this case series was to evaluate outcomes of serial sharp debridement and the application of a formulated collagen gel in patients with chronic, nonhealing pressure ulcers. Three patients (two women ages 82 and 74 years of age and one man 82 years old, all incontinent of bladder and bowel with numerous comorbidities) had wounds >18 months' duration on the buttocks or coccyx that failed to improve despite the use of a wide variety of treatments, including negative pressure wound therapy. All wounds were debrided at the start of treatment and weekly thereafter if necessary, followed by application of the collagen gel. The gel was covered with a sterile bordered gauze and, if needed, a semipermeable dressing. Dressings were left in place for up to 1 week. Two ulcers reepithelialized completely after 4 to 5 weeks of care, and the wound bed of the third ulcer was ready for grafting after 6 weeks of care. No adverse events occurred. Nursing staff appreciated the reduced dressing change frequency, although dressing maintenance remains challenging in patients with frequent incontinence episodes. Randomized clinical trials to evaluate the efficacy of this treatment approach compared to the use of traditional moisture-retentive dressings are needed.
C1 [Agosti, Jennifer K.; Clark, Rita M.] Nurse Sharks Inc, Weedville, PA USA.
   [Chandler, Lois A.] Cardium Therapeut, Biol Dev, San Diego, CA USA.
   [Anderton, Caryn M.] Cardium Therapeut, Strateg Dev, San Diego, CA USA.
RP Agosti, JK (通讯作者)，661 Byrnedale Rd, Weedville, PA 15868 USA.
EM nursesharks@gmail.com
CR Ashby RL, 2012, TRIALS, V13, DOI 10.1186/1745-6215-13-119
   Blume P, 2011, WOUND REPAIR REGEN, V19, P302, DOI 10.1111/j.1524-475X.2011.00669.x
   Brett D, 2008, WOUNDS, V20, P347
   Ersser SJ, 2005, INT J NURS STUD, V42, P823, DOI 10.1016/j.ijnurstu.2004.12.003
   Graumlich JF, 2003, J AM GERIATR SOC, V51, P147, DOI 10.1046/j.1532-5415.2003.51051.x
   Gu DL, 2004, MOL THER, V9, P699, DOI 10.1016/j.ymthe.2004.02.018
   Kim EJ, 2006, INT J NURS STUD, V43, P447, DOI 10.1016/j.ijnurstu.2006.01.001
   Leaper DJ, 2012, INT WOUND J, V9, P1, DOI 10.1111/j.1742-481X.2012.01097.x
   Lyder CH, 2003, JAMA-J AM MED ASSOC, V289, P223, DOI 10.1001/jama.289.2.223
   Nain SP, 2011, J SURG TECH CASE REP, V3, P17
   Niezgoda Jeffrey A, 2006, Adv Skin Wound Care, V19 Suppl 1, P3, DOI 10.1097/00129334-200601001-00001
   Piatkowski A, 2012, J WOUND CARE, V21, P505, DOI 10.12968/jowc.2012.21.10.505
   Rangaraj A., 2011, Wounds uk, V7, P54
   Riley S, 2009, USING NEGATIVE PRESS, P2009
   Salcido R., PRESSURE ULCERS WOUN
   VanGilder C, 2010, ADV SKIN WOUND CARE, V23, P254, DOI 10.1097/01.ASW.0000363550.82058.7f
NR 16
TC 2
Z9 2
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD NOV
PY 2013
VL 59
IS 11
BP 43
EP 49
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 294YH
UT WOS:000330083300008
PM 24201171
DA 2026-07-24
ER

PT J
AU Gonzaga, TA
   Endorf, FW
   Mohr, WJ
   Ahrenholz, DH
AF Gonzaga, Teresa A.
   Endorf, Frederick W.
   Mohr, William J.
   Ahrenholz, David H.
TI Novel Surgical Approach for Axillary Hidradenitis Suppurativa Using a
   Bilayer Dermal Regeneration Template: A Retrospective Case Study
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT Midwestern Burn Regional Conference
CY SEP 28-30, 2011
CL Riverside, IA
ID MANAGEMENT
AB Hidradenitis suppurativa (HS) is a chronic debilitating disease of apocrine gland-bearing skin characterized by recurrent abscesses with subsequent rupture, scarring, and draining sinus tracts, most frequently affecting the axillary, inguinal, and anogenital regions. Conservative and temporizing treatment methods have been used to treat mild to moderate disease, but wide local excision of affected tissue is necessary for advanced disease. This creates a large soft tissue defect for which there is no consensus for reconstruction. Recovery is hampered by disease recurrence, tissue necrosis, and reoperation. The authors have described in this case study an alternative surgical approach to treat severe HS. All surgical procedures were performed by dedicated burn surgeons at a regional burn center using a two-stage surgical approach. The first stage is a wide local excision of all affected axillary tissue with immediate placement of a bilayer dermal regeneration template to cover the defect. This is secured with a negative pressure wound therapy dressing. The second stage uses a thin split thickness skin graft to close the wound. Results of four patients are presented. There were no recurrences of HS. Two patients required reoperations to address granulation tissue overgrowth and small areas of autograft loss. One patient experienced skin substitute loss as a result of infection. Inadequate excision of HS is the leading cause of disease recurrence. Using a bilayer dermal regeneration template with subsequent skin graft, surgeons can be aggressive in their excision of HS, achieving satisfactory functional and cosmetic results and minimizing axillary recurrence. (J Burn Care Res 2013;34:51-57)
C1 [Gonzaga, Teresa A.; Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Reg Hosp, Burn Ctr, St Paul, MN 55101 USA.
   [Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Reg Hosp, Dept Trauma & Gen Surg, St Paul, MN 55101 USA.
   [Endorf, Frederick W.; Mohr, William J.; Ahrenholz, David H.] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Gonzaga, TA (通讯作者)，Reg Hosp, Burn Ctr, 640 Jackson St, St Paul, MN 55101 USA.
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   Gottlieb M, 2005, MANAGEMENT COMPLEX P
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NR 18
TC 25
Z9 27
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2013
VL 34
IS 1
BP 51
EP 57
DI 10.1097/BCR.0b013e31826a7be7
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 068IH
UT WOS:000313359400018
PM 23128139
DA 2026-07-24
ER

PT J
AU Jeong, LD
   Zhang, TD
   Bald, M
   Anderson, L
   Moody, JP Jr
   Curwick, LP
   Beck, AW
   Myers, RP
AF Jeong, Leanne D.
   Zhang, Ting D.
   Bald, Madeline
   Anderson, Luke
   Moody Jr, John Patrick
   Curwick, Lauren P.
   Beck, Adam W.
   Myers, Rene P.
TI Prophylactic Absorbable Antibiotic Beads in Groin Reconstruction
   Following Vascular Procedures
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID LOADED POLYMETHYLMETHACRYLATE BEADS; CALCIUM-SULFATE BEADS; INFECTION;
   COMPLICATIONS; PREVENTION; MANAGEMENT; SURGERY; PROFILE; WOUNDS; BONE
AB Background: Postsurgical complications following vascular procedures requiring a groin incision are common due to factors such as preexisting comorbidities and are complicated by the frequent use of synthetic grafts. While negative pressure wound therapy and muscle flap coverage are interventions that have been shown to improve vascular graft salvage rates in the groin, use of absorbable antibiotic beads (AABs) may offer another useful adjunct to reduce adverse outcomes. This study evaluated the outcomes in patients receiving AABs during groin reconstruction following vascular procedures at a large tertiary-care hospital. Methods: A retrospective review was performed of all patients undergoing vascular surgery in the groin followed by reconstruction by the Plastic and Reconstructive Surgery service from January 2018 to March 2024. Patients were grouped by whether prophylactic AABs were placed during groin reconstruction. Results: Among 63 cases, 20 received AABs. Bivariate analysis showed significantly lower reoperation rates in the AAB group (P = 0.046). Multivariable analysis revealed AAB was associated with a significantly lower odds of composite major complications (P = 0.015), 30-day readmissions (P = 0.012), and reoperation (P = 0.003) following groin reconstruction. AAB use was not a significant predictor for length of stay, composite minor complications, postoperative packed red blood cells transfusions, long-term wound care, or surgical site infection. Conclusion: Use of AABs during groin reconstruction was associated with improved outcomes, including significantly lower rates of reoperations, readmission, and major complications suggesting a potential benefit in managing complex groin wounds.
C1 [Jeong, Leanne D.; Zhang, Ting D.; Bald, Madeline; Anderson, Luke; Moody Jr, John Patrick; Curwick, Lauren P.; Myers, Rene P.] Univ Alabama Birmingham, Dept Surg, Div Plast Surg, Birmingham, AL USA.
   [Beck, Adam W.] Univ Alabama Birmingham, Dept Surg, Div Vasc Surg & Endovascular Therapy, Birmingham, AL USA.
   [Jeong, Leanne D.] 1808 7th Ave South,Boshell Diabet Buidling 505, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Jeong, LD (通讯作者)，1808 7th Ave South,Boshell Diabet Buidling 505, Birmingham, AL 35233 USA.
EM leannej@uab.edu
OI Anderson, Luke/0009-0009-8836-9163
CR Abosala Abdulbaset, 2020, J Bone Jt Infect, V5, P43, DOI [10.7150/jbji.41743, 10.7150/jbji.41743]
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD JUL
PY 2026
VL 128
BP 445
EP 452
DI 10.1016/j.avsg.2026.03.019
EA APR 2026
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA GU7VM
UT WOS:001745541700001
PM 41895593
DA 2026-07-24
ER

PT J
AU Abdelwahab, SI
   Taha, MME
   Elhilu, AH
   Almuwallad, A
   Albargi, H
   Harthi, N
   Alharbi, RJ
   Sayegh, AA
   Zaid, AN
AF Abdelwahab, Siddig Ibrahim
   Taha, Manal Mohamed Elhassan
   Elhilu, Abdelkhalig Hussein
   Almuwallad, Ateeq
   Albargi, Hussin
   Harthi, Naif
   Alharbi, Rayan J.
   Sayegh, Anas A.
   Zaid, Abdel Naser
TI Trends, hotspots, and thematic evolution in damage control surgery
   research: a global bibliometric assessment
SO UPDATES IN SURGERY
LA English
DT Article; Early Access
DE Aabdominal trauma; Bibliometrics; Damage control surgery; Research
   trends; Trauma surgery
AB Damage control surgery (DCS) is a cornerstone of modern trauma care, yet its global research landscape remains unmapped. Despite significant clinical advances, no bibliometric study has systematically examined the intellectual and conceptual structure of DCS scholarship. This study aims to provide the first data-driven global bibliometric analysis of DCS, outlining publication trends, influential contributors, conceptual hotspots, thematic evolution, and emerging research frontiers. Scopus-indexed original articles (1997-2025) were analyzed using Bibliometrix, VOSviewer, and Sankeymatic/RAWGraphs. Analyses included performance metrics, citation patterns, author and institutional productivity, co-authorship and international collaboration networks, keyword co-occurrence mapping, thematic evolution (Callon's centrality/density), trending-topic overlays, and bibliographic coupling. The final dataset comprised 329 articles across 155 sources. Annual publication growth increased steadily, with accelerated expansion after 2010. The United States led in output and citation impact, followed by South Africa, Italy, China, and the United Kingdom. Collaboration analysis revealed 63 contributing countries, with a 30-country largest connected component. Co-occurrence mapping identified core themes such as damage control surgery, open abdomen, abdominal trauma, and temporary abdominal closure. Thematic analysis showed DCS transitioning from foundational concepts toward specialized domains, including negative-pressure wound therapy, abdominal wall reconstruction, and ballistic trauma. Trending-topic analysis highlighted rising interest in surgical management frameworks, cohort studies, abdominal sepsis, and military-related injuries. DCS research demonstrates sustained global growth, expanding international collaboration, and increasing methodological sophistication. Findings highlight evolving thematic priorities and identify future opportunities in precision trauma care, adjunctive technologies, and multicenter outcomes research.
C1 [Abdelwahab, Siddig Ibrahim] Jazan Univ, Hlth Res Ctr, Jazan, Saudi Arabia.
   [Almuwallad, Ateeq; Albargi, Hussin; Harthi, Naif; Alharbi, Rayan J.] Jazan Univ, Fac Nursing & Hlth Sci, Dept Nursing, Emergency Med Serv Programme, Jazan, Saudi Arabia.
   [Taha, Manal Mohamed Elhassan; Elhilu, Abdelkhalig Hussein; Sayegh, Anas A.; Zaid, Abdel Naser] Jazan Univ, Dept Surg, Jazan, Saudi Arabia.
C3 Jazan University; Jazan University; Jazan University
RP Abdelwahab, SI (通讯作者)，Jazan Univ, Hlth Res Ctr, Jazan, Saudi Arabia.
EM sadiqa@jazanu.edu.sa; manalroa@yahoo.com
RI Elhilu, Abdelkhalig/JWO-9293-2024; TAHA, MANAL/C-5968-2011; Harthi,
   Naif/AHD-8190-2022; Albargi, Hussin/JVD-8645-2023; Sayegh,
   Anas/QIR-2247-2026; ABDELWAHAB, Siddig/E-8929-2010; Alharbi,
   Rayan/AAD-4295-2021
FU Research, Development, and Innovation Authority (RDIA) - Kingdom of
   Saudi Arabia [12899-jazzan-2023-JZU-R-2-1-HW]
FX This research article is derived from a research grant funded by the
   Research, Development, and Innovation Authority (RDIA) - Kingdom of
   Saudi Arabia - with grant number (12899-jazzan-2023-JZU-R-2-1-HW).
CR Aria M, 2017, J INFORMETR, V11, P959, DOI 10.1016/j.joi.2017.08.007
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   Weale R, 2019, TRAUMA SURG ACUTE CA, V4, DOI 10.1136/tsaco-2018-000235
   Weil L, 2025, COLON TRAUMA, V271, P272
   Wongwaisayawan S, 2023, INT J SURG CASE REP, V111, DOI 10.1016/j.ijscr.2023.108864
   Ye HR, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e18840
NR 45
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD 2026 MAR 23
PY 2026
DI 10.1007/s13304-026-02612-y
EA MAR 2026
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GJ2DY
UT WOS:001737682500001
PM 41961462
DA 2026-07-24
ER

PT J
AU Sanna, A
   Targa, S
   Mantovan, B
   De Luca, M
AF Sanna, Andrea
   Targa, Simone
   Mantovan, Barbara
   De Luca, Maurizio
TI The Enhanced-View Totally Extraperitoneal Repair for Ventral and
   Incisional Hernia: Midterm Results of an Evolving Technique
SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES
LA English
DT Article
DE hernia; eTEP; ventral and incisional hernia; minimally invasive
   technique
ID COMPLICATIONS; METAANALYSIS; MESH
AB Introduction: In the field of abdominal wall hernias, several innovative procedures have been developed, including the extended/enhanced-view totally extraperitoneal (eTEP) hernia repair technique. Initially introduced for laparoscopic hernia repair by J. Daes, it was subsequently applied to ventral hernia repair (VHR) and incisional hernia repair (IVHR) by I. Belyansky et al. This article presents the midterm experience and outcomes of our center's experience with the endoscopic technique based on the principles of eTEP during IVHR and VHR.Method: A review was conducted of a prospectively collected database of abdominal wall hernia. Patients who underwent eTEP VHR or IVHR between October 2018 and February 2021 were identified.Results: A total of 51 patients underwent an eTEP-RS or eTEP-TAR procedure, with a 24-month follow-up period. Of the 51 patients included in the study, 43 underwent eTEP-RS treatment, while 8 required an additional transversus abdominis release (3 unilaterally). One patient developed a large hematoma necessitating reoperation and drainage via the eTEP approach. Seven patients developed seromas, which were treated conservatively, while 2 patients experienced surgical site infections, which were managed with a single-use negative pressure wound therapy system. Two patients exhibited recurrence at sites above the epigastric edge of the mesh.Conclusion: Moreover, the advancement of minimally invasive surgical techniques for abdominal wall reconstruction has rendered the eTEP approach a viable option for both primary and incisional VHR, with promising midterm outcomes.
C1 [Sanna, Andrea; Targa, Simone; Mantovan, Barbara; De Luca, Maurizio] Aulss 5 Polesana, Dept Gen Surg, Viale Tre Martiri 89, I-45100 Rovigo, Italy.
C3 ULSS 5 Polesana
RP Sanna, A (通讯作者)，Aulss 5 Polesana, Dept Gen Surg, Viale Tre Martiri 89, I-45100 Rovigo, Italy.
EM and_sanna@yahoo.it
RI sanna, andrea/IWE-3206-2023
OI sanna, andrea/0000-0002-5615-6915
CR Al Chalabi H, 2015, INT J SURG, V20, P65, DOI 10.1016/j.ijsu.2015.05.050
   Belyansky I, 2018, SURG ENDOSC, V32, P1525, DOI 10.1007/s00464-017-5840-2
   Binnebösel M, 2010, HERNIA, V14, P71, DOI 10.1007/s10029-009-0580-4
   Bittner JG, 2018, The Art of hernia surgery, P115
   Carbonel A., 2016, HERNIA SURG CURRENT
   Daes J, 2021, J AM COLL SURGEONS, V233, pE1, DOI 10.1016/j.jamcollsurg.2021.05.007
   Daes J, 2012, SURG ENDOSC, V26, P1187, DOI 10.1007/s00464-011-1993-6
   Eriksen J R, 2007, Hernia, V11, P481, DOI 10.1007/s10029-007-0282-8
   Forbes SS, 2009, BRIT J SURG, V96, P851, DOI 10.1002/bjs.6668
   Jani K, 2019, J MINIM ACCESS SURG, V15, P362, DOI 10.4103/0972-9941.188630
   Jani K, 2019, J MINIM ACCESS SURG, V15, P287, DOI 10.4103/jmas.JMAS_20_19
   Jenkins ED, 2010, SURG ENDOSC, V24, P3002, DOI 10.1007/s00464-010-1076-0
   Kokotovic D, 2016, JAMA-J AM MED ASSOC, V316, P1575, DOI 10.1001/jama.2016.15217
   Kumar N, 2021, SURG ENDOSC, V35, P5072, DOI 10.1007/s00464-020-07990-x
   LEBLANC KA, 1993, SURG LAPAROSC ENDOSC, V3, P39
   Miserez M, 2002, SURG ENDOSC, V16, P1207, DOI 10.1007/s00464-001-9198-z
   Muysoms F, 2018, HERNIA, V22, P743, DOI 10.1007/s10029-018-1804-2
   Parker S, 2018, SPRINGER EBOOKS, P103, DOI [10.1007/978-3-319-72626-7_10, DOI 10.1007/978-3-319-72626-7_10, 10.1007/978-3-319-72626-710]
   Penchev D, 2019, SURG ENDOSC, V33, P3749, DOI 10.1007/s00464-019-06669-2
   Qandeel H, 2016, SURG ENDOSC, V30, P1480, DOI 10.1007/s00464-015-4356-x
   Quezada N, 2022, SURG ENDOSC, V36, P632, DOI 10.1007/s00464-021-08330-3
   Ramana B, 2021, HERNIA, V25, P545, DOI 10.1007/s10029-020-02216-4
   Sanna A, 2020, J LAPAROENDOSC ADV S, V30, P246, DOI 10.1089/lap.2019.0661
   Suwa K, 2016, SURG TODAY, V46, P764, DOI 10.1007/s00595-015-1219-y
   Tasdelen HA, 2023, SURG ENDOSC, V37, P3260, DOI 10.1007/s00464-023-09922-x
   Tasdelen HA, 2022, SURG ENDOSC, V36, P4614, DOI 10.1007/s00464-021-08995-w
   Zhang YY, 2014, WORLD J SURG, V38, P2233, DOI 10.1007/s00268-014-2578-z
NR 27
TC 0
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-6429
EI 1557-9034
J9 J LAPAROENDOSC ADV S
JI J. Laparoendosc. Adv. Surg. Tech.
PD JAN 1
PY 2025
VL 35
IS 1
BP 48
EP 54
DI 10.1089/lap.2023.0354
EA DEC 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA S5Y9I
UT WOS:001372196000001
PM 39648768
DA 2026-07-24
ER

PT J
AU Alt, V
   Rupp, M
   Kerschbaum, M
   Prantl, L
   Geis, S
AF Alt, Volker
   Rupp, Markus
   Kerschbaum, Maximilian
   Prantl, Lukas
   Geis, Sebastian
TI Treatment strategies for fracture-related infections with concurrent
   soft tissue damage
SO UNFALLCHIRURGIE
LA German
DT Review
DE Fracture-related infection; Surgical flaps; Ortho-plastic; Negative
   pressure wound therapy; Debridement
ID PRESSURE WOUND THERAPY; LOWER-EXTREMITY RECONSTRUCTION; ANTEROLATERAL
   THIGH; LOWER-LIMB; PERFORATOR FLAPS; DEFECTS; MANAGEMENT; COVERAGE;
   TRAUMA; SERIES
AB Fracture-related infections are the predominant complication following surgical fracture treatment. The distal lower leg, e.g., in pilon tibial fractures, is at a high risk of infection due to poor soft tissue coverage, particularly in cases of open fractures in this area. Fracture-related infections with significant soft tissue damage require special attention alongside treatment of the infection itself. In general, the principle is that healing of fracture-related infection is not possible without sufficient soft tissue coverage. Therefore, it is crucial to integrate both soft tissue damage and fracture-related infection into a comprehensive treatment plan from the beginning. An interdiscpilinary treatment approach between trauma and plastic surgery is often necessary and beneficial. In cases, where fracture fixation devices or bone is exposed, mid- or long-term use of vacuum-assisted wound therapy is not advisable due to a higher risk of reinfection. Hence, an interdisciplinary treatment strategy involving trauma and plastic surgery should prioritize early soft tissue closure, referred to as the "orthoplastic approach". If this cannot be done in the own hospital, early patient transfer is indicated to ensure optimal interdisciplinary therapy with early soft tissue closure and simultaneous trauma surgical treatment to control the infection and enable bone healing. Free fasciocutaneous or muscle flap techniques in combination with adequate trauma surgical and antibiotic therapy lead to good reliable results in these situations.
C1 [Alt, Volker; Rupp, Markus; Kerschbaum, Maximilian] Univ Klinikum Regensburg UKR, Klin & Poliklin Unfallchirurg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
   [Prantl, Lukas; Geis, Sebastian] Univ Klinikum Regensburg UKR, Abt Plast Hand & Wiederherstellungschirurg, Regensburg, Germany.
C3 University of Regensburg; University of Regensburg
RP Alt, V (通讯作者)，Univ Klinikum Regensburg UKR, Klin & Poliklin Unfallchirurg, Franz Josef Str Allee 11, D-93053 Regensburg, Germany.
EM volker.alt@ukr.de
RI Rupp, Markus/ABH-5784-2022; Prantl, Lukas/AAM-1848-2021
CR Bajantri B, 2012, INDIAN J PLAST SURG, V45, P283, DOI 10.4103/0970-0358.101299
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NR 40
TC 3
Z9 3
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD FEB
PY 2024
VL 127
IS 2
SI SI
BP 103
EP 109
DI 10.1007/s00113-023-01403-z
EA JAN 2024
PG 7
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA D4N0H
UT WOS:001229039600001
PM 38167783
DA 2026-07-24
ER

PT J
AU Braungart, S
   Powis, M
   Sutcliffe, JR
   Sugarman, ID
AF Braungart, Sarah
   Powis, Mark
   Sutcliffe, Jonathan R.
   Sugarman, Ian D.
TI Improving outcomes in pilonidal sinus disease
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the British-Association-of-Paediatric-Surgeons
CY JUL 22-24, 2015
CL Cardiff, WALES
SP British Assoc Paediat Surg
DE Pilonidal sinus; Operative technique
ID VACUUM-ASSISTED CLOSURE; LIMBERG FLAP; RHOMBOID EXCISION; WOUND
   MANAGEMENT; EARLY EXPERIENCE
AB Background: Optimal surgical treatment for pilonidal sinus disease remains controversial. Studies in children are uncommon with overall high postoperative recurrence and infection rates (20%). Our unit adopted a technique for excision of the pilonidal sinus with primary midline closure using a full-thickness flap. We present our results of this technique in the pediatric age group.
   Methods: Single-center retrospective review and telephone follow-up was performed, including all children undergoing pilonidal sinus excision from 2005 to 2014 using the same operative technique and preoperative/postoperative care.
   Results: 19 children were identified. Median age was 15 years, and 47% were male. All had previously infected sinuses, with 5 requiring abscess drainage. Median follow-up was 13 months (3.5-67 months). Histology confirmed pilonidal sinus in 18/19 cases (one developmental malformation excluded from subsequent analysis). Recurrence requiring further surgery occurred in 4/18 (22%) patients at a median of 9 months (range 8-36), wound dehiscence in 8/18 (44%), and wound infection in 5/18 (28%) cases. Laser hair removal of the natal cleft was performed in 7/18 (39%) patients with no further recurrence.
   Conclusion: This is the first report of this technique in children which showed a higher incidence of complications than a comparable adult study. Our study underlines the importance of accurate long-term outcomes when introducing new techniques to evaluate operation-associated morbidity. Our preliminary results of laser hair removal are promising but need to be evaluated with a prospective study. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Braungart, Sarah; Powis, Mark; Sutcliffe, Jonathan R.; Sugarman, Ian D.] Leeds Teaching Hosp NHS Trust, Dept Paediat Surg, Leeds, W Yorkshire, England.
C3 University of Leeds
RP Sugarman, ID (通讯作者)，Leeds Gen Infirm, Leeds Teaching Hosp NHS Trust, Dept Paediat Surg, Great George St, Leeds LS1 3EX, W Yorkshire, England.
EM ian.sugarman@nhs.net
CR Abbas MA, 2006, DIS COLON RECTUM, V49, P1242, DOI 10.1007/s10350-006-0617-z
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NR 27
TC 32
Z9 40
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD FEB
PY 2016
VL 51
IS 2
BP 282
EP 284
DI 10.1016/j.jpedsurg.2015.10.076
PG 3
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA DE7JA
UT WOS:000370810800020
PM 26690708
DA 2026-07-24
ER

PT J
AU Fu, G
   Wang, D
   Qin, BG
   Xiang, JP
   Qi, J
   Li, P
   Zhu, QT
   Liu, XL
   Zhu, JK
   Gu, LQ
AF Fu, Guo
   Wang, Dong
   Qin, Bengang
   Xiang, Jianping
   Qi, Jian
   Li, Ping
   Zhu, Qingtang
   Liu, Xiaolin
   Zhu, Jiakai
   Gu, Li-Qiang
TI Modified Classification and Repair of Perineal Soft Tissue Injuries
   Associated with Open Pelvic Fractures
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE open pelvic fractures; soft tissue injuries; classification
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; VAC(TM); WOUNDS
AB BackgroundThis study describes a modified classification and management protocol for perineal soft tissue injuries associated with pelvic fractures.
   MethodsA total of 11 patients with perineal soft tissue injuries associated with open pelvic fractures were studied retrospectively. The patients were classified into three types based on the area of defect: type A (urogenital zone), type B (anal zone), and type C (both urogenital and anal zones). Each type included the following subclasses: A1 (without urethra injuries), A2 (with urethra injuries), B1 (without anorectal injuries), B2 (with anorectal injuries), C1 (with types A1 and B1), C2 (with types A2 and B1), C3 (with types A1 and B2), and C4 (with types A2 and B2). The management protocol was planned according to the individual classifications. Protocol A1 (for type A1) involved skin graft or myocutaneous flap transplantation. Protocol A2 (for type A2) involved the same protocol combined with urine diversion. Protocol B1 (for type B1) involved skin graft or myocutaneous flap transplantation. Protocol B2 (for type B2) involved the same management combined with fecal diversion. Protocol C involved the correspondent protocol used for each subtype of type C.
   ResultsOut of the 11 patients, there were 5, 3, and 3 cases of types A, B, and C, respectively. One patient died due to sepsis, and the wounds of the remaining patients healed well. No anal incontinence had occurred.
   ConclusionsPerineal soft tissue injuries associated with pelvic fractures can be classified into three types, and the management protocol can be planned according to the classification.
C1 [Fu, Guo; Wang, Dong; Qin, Bengang; Xiang, Jianping; Qi, Jian; Li, Ping; Zhu, Qingtang; Liu, Xiaolin; Zhu, Jiakai; Gu, Li-Qiang] Sun Yat Sen Univ, Dept Microsurg & Trauma Surg, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Gu, LQ (通讯作者)，Sun Yat Sen Univ, Dept Microsurg & Trauma Surg, Affiliated Hosp 1, 58 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China.
EM guliqiang1963@aliyun.com
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NR 34
TC 9
Z9 11
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JAN
PY 2015
VL 31
IS 1
BP 12
EP 19
DI 10.1055/s-0034-1386616
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AY1TO
UT WOS:000347375100002
PM 25226084
DA 2026-07-24
ER

PT J
AU Stiegler, P
   Matzi, V
   Pierer, E
   Hauser, O
   Schaffellner, S
   Renner, H
   Greilberger, J
   Aigner, R
   Maier, A
   Lackner, C
   Iberer, F
   Smolle-Jüttner, FM
   Tscheliessnigg, K
   Stadlbauer, V
AF Stiegler, Philipp
   Matzi, Veronika
   Pierer, Eve
   Hauser, Oliver
   Schaffellner, Silvia
   Renner, Heiko
   Greilberger, Joachim
   Aigner, Reingard
   Maier, Alfred
   Lackner, Carolin
   Iberer, Florian
   Smolle-Juettner, Freyja-Maria
   Tscheliessnigg, Karlheinz
   Stadlbauer, Vanessa
TI Creation of a prevascularized site for cell transplantation in rats
SO XENOTRANSPLANTATION
LA English
DT Article
DE angiogenesis; HEK293; hyperbaric oxygenation; islet cells;
   microencapsulation; vacuum-assisted wound closure; xenotransplantation
ID ENDOTHELIAL GROWTH-FACTOR; HYPERBARIC-OXYGEN TREATMENT;
   VACUUM-ASSISTED-CLOSURE; INOPERABLE PANCREATIC-CARCINOMA;
   MICROENCAPSULATED ISLET GRAFTS; SODIUM CELLULOSE SULFATE; OXIDATIVE
   DNA-DAMAGE; BIOARTIFICIAL PANCREAS; ANTIOXIDANT STATUS; PORCINE ISLETS
AB Introduction:
   Transplanted cells, especially islet cells, are likely to become apoptotic due to local hypoxia leading to graft dysfunction. Isolated pancreatic islet cells depend on the diffusion of oxygen from the surrounding tissue; therefore, access to sufficient oxygen supply is beneficial, particularly when microcapsules are used for immunoisolation in xenotransplantation. The aim of this study was to create a prevascularized site for cell transplantation in rats and test its effectiveness with microencapsulated HEK293 cells.
   Methods:
   The combination of implantation of a foam dressing, vacuum-assisted wound closure (foam+VAC) and hyperbaric oxygenation (HBO) was used in 40 Sprague-Dawley rats. Blood flow and vascular endothelial growth factor (VEGF) levels were determined. Sodium cellulose sulphate (SCS)-microencapsulated HEK293 cells were xenotransplanted into the foam dressing in rats pre-treated with HBO, and angiogenesis and apoptosis were assessed.
   Results:
   Vessel ingrowth and VEGF levels increased depending on the duration of HBO treatment. The area containing the foam was perfused significantly better in the experimental groups when compared to controls. Only a small amount of apoptosis occurs in SCS-microencapsulated HEK293 cells after xenotransplantation.
   Conclusion:
   As ischemia-damaged cells are likely to undergo cell death or loose functionality due to hypoxia, therefore leading to graft dysfunction, the combination foam+VAC and HBO might be a promising method to create a prevascularized site to achieve better results in xenogeneic cell transplantation.
C1 [Stiegler, Philipp; Pierer, Eve; Schaffellner, Silvia; Iberer, Florian; Tscheliessnigg, Karlheinz] Med Univ Graz, Dept Surg, Div Transplantat Surg, A-8036 Graz, Austria.
   [Matzi, Veronika; Renner, Heiko; Maier, Alfred; Smolle-Juettner, Freyja-Maria] Med Univ Graz, Dept Surg, Div Thorac Surg & Hyperbar Med, A-8036 Graz, Austria.
   [Hauser, Oliver] Ziel Biopharma Ltd, Cork, Ireland.
   [Greilberger, Joachim] Med Univ Graz, Ctr Physiol Med, Inst Physiol Chem, A-8036 Graz, Austria.
   [Aigner, Reingard] Med Univ Graz, Dept Radiol, Div Nucl Med, A-8036 Graz, Austria.
   [Lackner, Carolin] Med Univ Graz, Inst Pathol, A-8036 Graz, Austria.
   [Stadlbauer, Vanessa] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, A-8036 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz; Medical University of Graz; Medical University of
   Graz; Medical University of Graz
RP Stiegler, P (通讯作者)，Med Univ Graz, Dept Surg, Div Transplantat Surg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM philipp.stiegler@meduni-graz.at
OI Stiegler, Philipp/0000-0002-0952-3030; Stadlbauer,
   Vanessa/0000-0001-5508-8271
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NR 79
TC 17
Z9 17
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0908-665X
J9 XENOTRANSPLANTATION
JI Xenotransplantation
PD SEP-OCT
PY 2010
VL 17
IS 5
BP 379
EP 390
DI 10.1111/j.1399-3089.2010.00606.x
PG 12
WC Medicine, Research & Experimental; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Transplantation
GA 667CL
UT WOS:000283170100006
PM 20955294
OA Bronze
DA 2026-07-24
ER

PT J
AU Olsen, LT
   Fuller, DA
   Milton, J
   Hunt, GJ
AF Olsen, L. Todd
   Fuller, David A.
   Milton, Joseph
   Hunt, G. Jason
TI Subatmospheric Pressure Therapy in the Healing of a Palmar Hand Wound
   With Exposed Median Nerve in a Diabetic Patient
SO ORTHOPEDICS
LA English
DT Article
AB The management of diabetic hand abscesses can be challenging. Wound management after decompression and debridement is complicated by the presence of infection, chronic wound edema, and inhibitory healing factors. An amputation rate of > 60% has been reported.
   This article reports a case of the treatment of a difficult diabetic hand wound with an exposed median nerve. A 56-year-old man presented with a 7-day history of swelling, pain, and erythema in his dominant hand. After serial irrigations and debridement, he had an open wound of the wrist and exposed median nerve. Standard wound vacuum assisted closure (V.A.C.; KCI, San Antonio, Texas) placement was used. After 4 weeks of treatment, the wound had complete granulation, and full epithelial coverage occurred at 10 weeks. Direct application of the wound V.A.C. on an exposed peripheral nerve had not been described.
   It is not clear if the final sensory and motor deficits in the operative hand represent preexisting disease or are the result of the patient's hand infection. Despite the sensory and motor deficits observed during follow-up, the patient was satisfied with his clinical outcome. Application of the V.A.C. system was vital in the elimination of infection and promotion of tissue healing for this historically difficult diabetic hand infection that may have otherwise resulted in a loss of the hand. The V.A.C. system may provide a useful treatment modality in similar difficult wounds with exposed peripheral nerves.
C1 [Olsen, L. Todd] Olsen Orthoped, Midwest City, OK USA.
   [Hunt, G. Jason] St Anthony Hosp, Oklahoma City, OK USA.
   [Fuller, David A.] Univ Med & Dent New Jersey, Cooper Univ Hosp, Newark, NJ 07103 USA.
   [Milton, Joseph] Cooper Univ Hosp, Camden, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Cooper University Hospital
RP Hunt, GJ (通讯作者)，5117 Robin Hill Ln, Oklahoma City, OK 73150 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0147-7447
J9 ORTHOPEDICS
JI Orthopedics
PD OCT
PY 2008
VL 31
IS 10
BP 1045
EP 1045
PG 1
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 359JW
UT WOS:000259984000025
PM 19225996
DA 2026-07-24
ER

PT J
AU Benedix, F
   Lippert, H
   Meyer, F
AF Benedix, F.
   Lippert, H.
   Meyer, F.
TI Post-surgical lymphocutaneous fistula, chylous ascites and chylothorax -
   Infrequent but serious complications: Etiology, diagnosis and
   therapeutic options review
SO ZENTRALBLATT FUR CHIRURGIE
LA English
DT Article
DE lymphorrhea; lymphocutaneous fistula; chylous ascites; chylothorax;
   postoperative complication
ID VACUUM-ASSISTED CLOSURE; OF-THE-LITERATURE; POSTOPERATIVE CHYLOTHORAX;
   LYMPHATIC FISTULAS; THORACIC-DUCT; ARTERIAL RECONSTRUCTION; PERCUTANEOUS
   CATHETERIZATION; DOXYCYCLINE TREATMENT; WOUND CONTROL; MANAGEMENT
AB Lymphorrhea is an uncommon but potentially life-threatening complication following surgical procedures which strongly influences the outcome of surgical patients. Persistent lymphocutaneous fistula is mainly associated with an increased risk of local infections and wound complications. Chylous ascites and chylothorax can result in malnutrition, metabolic deterioration and immunosuppression that increase postsurgical morbidity. Diagnosis can easily be made by the characteristic milky-beige appearance of chylous fluid. Laboratory investigation of the drainage fluid (chylomicrons, triglycerides) enables to confirm diagnosis. Initial therapy favors conservative measures including drainage, pressure dressings, total parenteral nutrition and diet modifications. But this takes sometimes several weeks to control the chylous leak and leads to prolonged hospital is ation. Surgical options are only recommended if conservative therapy fails. However, surgical re-interventions are associated with significant incidence of morbidity and mortality. In addition, surgery may occasionally fail to identify the leak. Some promising new techniques have recently been introduced (application of octreotide or etilefrine, low-dose radiotherapy, use of sclerosing agents, subatmospheric pressure dressings or percutaneous embolization of cisterna chyli), which - alone or in combination with well-established conservative measures - may have the potential to avoid surgical re-interventions. Prevention of lymphorrhea during primary operation is of major importance. The present study focusses on current diagnostic and therapeutic options in the treatment of lymphocutaneous fistula, chylous ascites and chylothorax as the most frequent entities of lymphorrhea.
C1 [Benedix, F.; Lippert, H.; Meyer, F.] Univ Klinikum, Chirurg Klin, D-39120 Magdeburg, Germany.
C3 University Hospital Magdeburg
RP Benedix, F (通讯作者)，Univ Klinikum, Chirurg Klin, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM frankbenedix@gmx.de
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NR 67
TC 15
Z9 19
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD DEC
PY 2007
VL 132
IS 6
BP 529
EP 538
DI 10.1055/s-2007-981364
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 249HW
UT WOS:000252219900009
PM 18098081
DA 2026-07-24
ER

PT J
AU Tang, D
   Liu, CM
   Chen, X
   Lv, X
   Yuan, LL
   Xue, DD
   Song, HP
AF Tang, Di
   Liu, Chunmei
   Chen, Xia
   Lv, Xian
   Yuan, Lili
   Xue, Dongdong
   Song, Huapei
TI The associations between diode laser (810 nm) therapy and chronic wound
   healing and pain relief: Light into the chronic wound patient's life
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE chronic wound; diode laser therapy; pain relief index; wound healing
   time
ID OPTICAL-PROPERTIES; SKIN; BURN; RED
AB Chronic wounds have become one of the major issues in medicine today, the treatments for which include dressing changes, negative pressure wound therapy, hyperbaric oxygen, light irradiation, surgery and so forth. Nevertheless, the application of diode lasers in chronic wounds has rarely been reported. This retrospective cohort study aimed to evaluate the therapeutic effect of diode laser (810 nm) irradiation on chronic wounds. Eighty-nine patients were enrolled in the study. The control group (41 patients) received traditional dressing change therapy, while the diode laser treatment group (48 patients) were patients received additional treatment with diode laser (810 nm) irradiation for 10 min at each dressing change. Wound healing time was compared between two groups, while the pain relief index was creatively introduced to evaluate the effect of relieving wound pain, which was calculated by the difference in pain scores between the first and last dressing changes divided by the number of treatment days. The wound healing time of the diode laser treatment group was 22.71 +/- 8.99 days, which was significantly shorter than that of the control group (37.44 +/- 23.42 days). The pain relief index of the diode laser treatment group was 0.081 +/- 0.055, which was significantly increased compared with that of the control group (0.057 +/- 0.033). Our findings suggest that diode laser irradiation has the potential to promote healing in chronic wounds and relieve wound pain.
C1 [Tang, Di; Liu, Chunmei; Chen, Xia; Lv, Xian; Yuan, Lili; Xue, Dongdong; Song, Huapei] Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China.
   [Tang, Di] Gen Hosp Cent Theater Command, Burn & Plast Surg Dept, Wuhan, Hubei, Peoples R China.
   [Xue, Dongdong] Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China.
C3 Army Medical University; Army Medical University
RP Xue, DD (通讯作者)，Army Med Univ, Southwest Hosp, Inst Burn Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400038, Peoples R China.
EM xuedongdong@tmmu.edu.cn; shpmajor@tmmu.edu.cn
OI Xue, Dongdong/0000-0003-2732-8316; Tang, Di/0000-0001-6052-578X
FU Chongqing Science and Technology Commission [cstc2018jscx-msybX0112];
   Natural Science Foundation of Hubei Province [2021CFB164]; Project of
   the State Key Laboratory of Trauma, Burn and Combined Injury, Third
   Military Medical University [SKLJYJF19]; Postdoctoral Fund of Central
   Theater General Hospital [BSH017]
FX Chongqing Science and Technology Commission, Grant/Award Number:
   cstc2018jscx-msybX0112; Natural Science Foundation of Hubei Province,
   Grant/Award Number: 2021CFB164; Project of the State Key Laboratory of
   Trauma, Burn and Combined Injury, Third Military Medical University,
   Grant/Award Number: SKLJYJF19; Postdoctoral Fund of Central Theater
   General Hospital, Grant/Award Number: BSH017
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NR 26
TC 5
Z9 6
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2023
VL 31
IS 2
BP 227
EP 232
DI 10.1111/wrr.13066
EA JAN 2023
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA I0TG6
UT WOS:000912201100001
PM 36541709
DA 2026-07-24
ER

PT J
AU Jeon, JH
   Kim, KW
   Jeon, HB
AF Jeon, Jae Hyung
   Kim, Kyung Wook
   Jeon, Hong Bae
TI Pedicled abdominal flap using deep inferior epigastric artery
   perforators for forearm reconstruction: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Forearm injury; Open fracture reduction; Perforator flap; Deep inferior
   epigastric artery perforators; Case report
ID GROIN
AB BACKGROUND Pedicled abdominal flaps are a widely used surgical technique for forearm reconstruction in patients with soft tissue defects. However, some drawbacks include restricted flap size, partial flap loss, and donor-site morbidity. To address these concerns, we present a case of a pedicled abdominal flap using the deep inferior epigastric artery perforators (DIEP) for forearm reconstruction in a patient with a large soft tissue defect. CASE SUMMARY A 46-year-old male patient was admitted to our hospital with forearm injury caused by a pressing machine. A 15 cm x 10 cm soft tissue defect with complete rupture of the ulnar side structures of the forearm was found. One week after orthopedic management of the neurovascular injury and fractures using the first stage of Masquelet technique, the patient was referred to the plastic and reconstructive surgery department for wound coverage. Surgical debridement and negative-pressure wound therapy revealed a 20 cm x 15 cm soft tissue defect. A pedicle abdominal flap with the DIEP was used to cover the defect. Three weeks later, the flap was detached from the abdomen, and the abdominal defect was directly closed. Subsequently, the second stage of Masquelet technique was performed at the fracture site at week 10. Finally, all donor and recipient sites healed without complications, such as flap dehiscence, infection, hematoma, or necrosis. Fracture site osteosynthesis was achieved without complications. CONCLUSION Pedicled abdominal flap using the DIEP provides a reliable option for forearm reconstruction in patients with large soft tissue defects.
C1 [Jeon, Jae Hyung] Dankook Univ Hosp, Dept Plast & Reconstruct Surg, Cheonan 31116, Chungnam, South Korea.
   [Kim, Kyung Wook] Dankook Univ, Coll Med, Dankook Univ Hosp, Dept Orthopaed Surg, Cheonan 31116, Chungnam, South Korea.
   [Jeon, Hong Bae] Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, 201 Manghyang Ro, Cheonan 31116, Chungnam, South Korea.
C3 Dankook University; Dankook University Hospital; Dankook University;
   Dankook University Hospital; Dankook University; Dankook University
   Hospital
RP Jeon, HB (通讯作者)，Dankook Univ, Dankook Univ Hosp, Coll Med, Dept Plast & Reconstruct Surg, 201 Manghyang Ro, Cheonan 31116, Chungnam, South Korea.
EM jeonhb110@dankook.ac.kr
RI Jeon, Hong-Bae/LFU-4551-2024
FU Bio&Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean government (MSIT) [RS-2023-00220408]
FX Supported by The Bio & Medical Technology Development Program of the
   National Research Foundation (NRF) funded by the Korean government
   (MSIT), No. RS-2023-00220408.
CR Adidharma Widya, 2022, J Hand Surg Glob Online, V4, P367, DOI [10.1016/j.jhsg.2022.07.005, 10.1016/j.jhsg.2022.07.005]
   Al-Qattan MM, 2016, J HAND SURG-AM, V41, P917, DOI 10.1016/j.jhsa.2016.06.006
   Anil R, 2017, J EVOL MED DENT SCI-, V6, P4711, DOI 10.14260/jemds/2017/1020
   Herter F, 2007, J PLAST RECONSTR AES, V60, P760, DOI 10.1016/j.bjps.2007.03.008
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NR 9
TC 0
Z9 1
U1 0
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD FEB 6
PY 2024
VL 12
IS 4
DI 10.12998/wjcc.v12.i4.828
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HG1J1
UT WOS:001158244600011
PM 38322698
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Roberts, DJ
   Murphy, C
   Strauss, SA
   Brandys, T
   Corrales-Medina, V
   Zhang, J
   Lalonde, KA
   Meulenkamp, B
   Jennings, A
   Forster, AJ
   McIsaac, DI
   Nagpal, SK
AF Roberts, Derek J.
   Murphy, Christine
   Strauss, Shira A.
   Brandys, Timothy
   Corrales-Medina, Vicente
   Zhang, Jing
   Lalonde, Karl-Andre
   Meulenkamp, Bradley
   Jennings, Alison
   Forster, Alan J.
   McIsaac, Daniel I.
   Nagpal, Sudhir K.
TI Structure, processes, and initial outcomes of The Ottawa Hospital
   Multi-Specialist Limb-Preservation Clinic and Programme: A
   unique-in-Canada quality improvement initiative
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE arterial ulcer; diabetic foot ulcer; limb-preservation clinic;
   postsurgical wound; venous ulcer; wounds and injuries
ID WOUND CARE CENTER; DIABETIC FOOT; MAJOR AMPUTATIONS; OF-LIFE; TEAM;
   MANAGEMENT; REVASCULARIZATION; EPIDEMIOLOGY; GUIDELINES; EXPERIENCE
AB In 2017, The Ottawa Hospital initiated a unique-in-Canada quality improvement initiative by opening a novel, multi-specialist limb-preservation clinic. We sought to describe the structure, processes, and initial outcomes of the clinic and evaluate whether it is achieving its mandate of providing high-quality wound clinical care, education, and research. We conducted a descriptive prospective cohort study alongside a nested study of 162 clinic patients requiring serial assessments. There have been 1623 visits, mostly (72.2%) from outpatients. During 17.8% of visits, patients were evaluated by >1 specialist. Therapies provided most often included negative-pressure wound therapy (32.7%), biological wound dressings (21.6%), and total contact casting (18.5%). Furthermore, 1.2% underwent toe/ray amputations or skin grafting in clinic and 22.8% were initiated on antimicrobials. Mixed-effects models suggested that mean wound volumes for those requiring serial assessments decreased by 1.6 (95% confidence interval = -0.86 to -2.27) cm(3) between visits. The clinic provided seven rotations to vascular surgery, infectious diseases, dermatology, and palliative care physicians; three nursing preceptorships; and two educational workshops. It also initiated provincial and national vascular health and wound care research initiatives. This study may be used to guide development of other limb-preservation clinics and programmes. Findings support that our programme is achieving its mandate.
C1 [Roberts, Derek J.; Murphy, Christine; Strauss, Shira A.; Brandys, Timothy; Nagpal, Sudhir K.] Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
   [Roberts, Derek J.; Jennings, Alison; Forster, Alan J.; McIsaac, Daniel I.] Ottawa Hosp Res Inst, Ottawa, ON, Canada.
   [Corrales-Medina, Vicente] Univ Ottawa, Dept Med, Div Infect Dis, Ottawa, ON, Canada.
   [Zhang, Jing] Univ Ottawa, Dept Surg, Div Plast & Reconstruct Surg, Ottawa, ON, Canada.
   [Lalonde, Karl-Andre; Meulenkamp, Bradley] Univ Ottawa, Dept Surg, Div Orthopaed Surg, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] IC ES, Toronto, ON, Canada.
   [Forster, Alan J.] Univ Ottawa, Dept Med, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] Ottawa Hosp, Ottawa, ON, Canada.
   [Forster, Alan J.; McIsaac, Daniel I.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Dept Anesthesiol, Ottawa, ON, Canada.
   [McIsaac, Daniel I.] Univ Ottawa, Dept Pain Med, Ottawa, ON, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; Ottawa Hospital Research Institute; University of Ottawa;
   University of Ottawa; University of Ottawa; University of Ottawa;
   University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; University of Ottawa; University of Ottawa
RP Roberts, DJ (通讯作者)，Univ Ottawa, Dept Surg, Div Vasc & Endovasc Surg, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.; Roberts, DJ (通讯作者)，Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa Hosp Civ Campus,Room A280,1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
EM derek.roberts01@gmail.com
RI Strauss, Shira/AAS-6859-2020; Roberts, Derek/L-6229-2019
OI Jennings, Alison/0000-0002-9452-3990; Corrales-Medina,
   Vicente/0000-0002-9691-491X
FU Department of Surgery, University of Ottawa (Ottawa, Ontario, Canada)
FX We thank Nadia Khan, MD, for assisting with taking photos of the clinic.
   This study was supported by funding from the Department of Surgery,
   University of Ottawa (Ottawa, Ontario, Canada).
CR Aksoy DY, 2004, EXP CLIN ENDOCR DIAB, V112, P526, DOI 10.1055/s-2004-821310
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   Bakker K, 2012, DIABETES-METAB RES, V28, P116, DOI 10.1002/dmrr.2254
   Benchimol EI, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001885
   Bosma J, 2013, ANN VASC SURG, V27, P1105, DOI 10.1016/j.avsg.2013.01.010
   Brennan MB, 2017, OPEN FORUM INFECT DI, V4, DOI 10.1093/ofid/ofx015
   Chi YW, 2015, VASC MED, V20, P168, DOI 10.1177/1358863X14568677
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   Khan T, 2018, DIABET FOOT ANKLE, V9, DOI 10.1080/2000625X.2018.1452513
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   Ontario CorHealth, 2021, VASCULAR VOLUMES OUT
   Peters CML, 2019, J VASC SURG, V70, P530, DOI 10.1016/j.jvs.2018.11.042
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   Steunenberg SL, 2016, ANN VASC SURG, V36, P310, DOI 10.1016/j.avsg.2016.05.087
   Sumpio BE, 2010, J VASC SURG, V51, P1504, DOI 10.1016/j.jvs.2010.04.010
   Thompson N, 2013, ADV SKIN WOUND CARE, V26, P360, DOI 10.1097/01.ASW.0000431329.50869.6f
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   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI [10.1016/j.jclinepi.2007.11.008, 10.1111/j.1468-1293.2008.00605.x, 10.1157/13073893]
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NR 36
TC 6
Z9 7
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2022
VL 19
IS 2
BP 326
EP 338
DI 10.1111/iwj.13633
EA JUN 2021
PG 13
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA YH4HX
UT WOS:000657516800001
PM 34085390
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Felder, JM
   Hechenbleikner, E
   Jordan, M
   Jeng, J
AF Felder, John M.
   Hechenbleikner, Elizabeth
   Jordan, Marion
   Jeng, James
TI Increasing the Options for Management of Large and Complex Chronic
   Wounds With a Scalable, Closed-System Dressing for Maggot Therapy
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID LARVAL THERAPY
AB As reconstructive specialists, burn surgeons are often involved in managing large wounds of various etiologies. Such wounds can pose a management challenge, especially if they are chronic or occur in the setting of critical illness or multiple medical comorbidities. Medical maggots are an effective, selective, and low-risk method for wound debridement. However, their use in large and geometrically complex wounds is limited by the lack of scalability in currently available dressings, which are appropriate for smaller wounds but become cumbersome and ineffective in larger ones. This report describes a novel dressing designed for application of maggot debridement therapy in large and complex wounds. The authors then discuss how use of this dressing may create new management strategies for such wounds by allowing maggots to mechanically debride big, infected wounds. They describe the construction of a maggot containment dressing based on modified components from a negative pressure wound therapy system and provide a case report highlighting its successful clinical use in a large contaminated chronic wound resulting from Fournier's gangrene. In the case described, the novel dressing provided scalability, containment of maggots, control of secretions, and ease of use. The dressing created an environment suitable for maggot survival and allowed effective debridement of a heavily contaminated groin wound. The novel dressing described is shown to function appropriately, allowing controlled use of maggots for effective debridement of large, irregular wounds. Facilitating the use of maggots in such wounds may broaden the algorithm for their management. (J Burn Care Res 2012;33:e169-e175)
C1 [Jordan, Marion; Jeng, James] Washington Hosp Ctr, Burn Ctr, Dept Surg, Washington, DC 20010 USA.
   [Felder, John M.] Georgetown Univ Hosp, Dept Plast Surg, Washington, DC 20007 USA.
   [Hechenbleikner, Elizabeth] Georgetown Univ Hosp, Dept Gen Surg, Washington, DC 20007 USA.
   [Jeng, James] Georgetown Univ, Sch Med, Dept Surg, Washington, DC USA.
C3 MedStar Washington Hospital Center; Georgetown University; Georgetown
   University; Georgetown University
RP Jeng, J (通讯作者)，Washington Hosp Ctr, Burn Ctr, Dept Surg, Washington, DC 20010 USA.
RI ; Felder, John/AHE-0063-2022
OI Jeng, James/0009-0009-9295-6782; Felder, John/0000-0003-4364-3623
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NR 25
TC 15
Z9 17
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2012
VL 33
IS 3
BP E169
EP E175
DI 10.1097/BCR.0b013e318233570d
PG 7
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 937PE
UT WOS:000303669600013
PM 21983646
DA 2026-07-24
ER

PT J
AU Akkus, G
   Sert, M
AF Akkus, Gamze
   Sert, Murat
TI Diabetic foot ulcers: A devastating complication of diabetes mellitus
   continues non-stop in spite of new medical treatment modalities
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetic foot ulcer; Peripheric artery disease; Macrovascular
   complications; Neuropathy; Wagner classification; Intralesionar growth
   factor treatment
ID HYPERBARIC-OXYGEN THERAPY; LOWER-EXTREMITY AMPUTATION; GROWTH-FACTOR;
   OXIDATIVE STRESS; IWGDF GUIDANCE; MANAGEMENT; NEUROPATHY;
   CLASSIFICATION; INFECTION; RISK
AB Diabetic foot ulcer is a devastating complication of diabetes mellitus and significant cause of mortality and morbidity all over the world and can be complex and costly. The development of foot ulcer in a diabetic patient has been estimated to be 19%-34% through their lifetime. The pathophysiology of diabetic foot ulcer consist of neuropathy, trauma and, in many patients, additional peripheral arterial disease. In particular, diabetic neuropathy leads to foot deformity, callus formation, and insensitivity to trauma or pressure. The standard algorithms in diabetic foot ulcer management include assessing the ulcer grade classification, surgical debridement, dressing to facilitate wound healing, off-loading, vascular assessment (status and presence of a chance for interventional vascular correction), and infection and glycemic control. Although especially surgical procedures are sometimes inevitable, they are poor predictive factors for the prognosis of diabetic foot ulcer. Different novel treatment modalities such as nonsurgical debridement agents, oxygen therapies, and negative pressure wound therapy, topical drugs, cellular bioproducts, human growth factors, energy-based therapies, and systematic therapies have been available for patients with diabetic foot ulcer. However, it is uncertain whether they are effective in terms of promoting wound healing related with a limited number of randomized controlled trials. This review aims at evaluating diabetic foot ulcer with regard to all aspects. We will also focus on conventional and novel adjunctive therapy in diabetic foot management.
C1 [Akkus, Gamze] Cukurova Univ, Dept Endocrinol, TR-33170 Adana, Turkey.
   [Sert, Murat] Cukurova Univ, Dept Internal Med, Med Fac, TR-33170 Adana, Turkey.
   [Akkus, Gamze] Cukurova Univ, Dept Endocrinol, Saricam St, TR-33170 Adana, Turkey.
C3 Cukurova University; Cukurova University; Cukurova University
RP Akkus, G (通讯作者)，Cukurova Univ, Dept Endocrinol, Saricam St, TR-33170 Adana, Turkey.
EM tugrulgamze@hotmail.com
RI /G-6103-2018; akkus, gamze/AAJ-7430-2020
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NR 93
TC 163
Z9 196
U1 14
U2 94
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD DEC 15
PY 2022
VL 13
IS 12
BP 1106
EP 1121
DI 10.4239/wjd.v13.i12.1106
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7K3LH
UT WOS:000905187000007
PM 36578865
OA Green Accepted, gold
HC Y
HP N
DA 2026-07-24
ER

PT J
AU Mehdorn, M
   Jansen-Winkeln, B
AF Mehdorn, Matthias
   Jansen-Winkeln, Boris
TI Modified Incisional Negative Pressure Wound Therapy Increases Seroma
   Evacuation: An Ex Vivo Model
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID SURGICAL SITE INFECTION; VENTRAL HERNIA REPAIR; MANAGEMENT;
   COMPLICATIONS; SURGERY; LAPAROTOMY
AB Background. Incisional negative wound pressure therapy (iNPWT) is a relatively novel dressing technique with the aim of reducing postoperative wound infections and dehiscence in high-risk wounds after all kinds of surgical procedures. There is a lack of theoretical knowledge about the way those dressing would ameliorate wound healing. One aspect is the reduction of superficial tension, but significant remaining seroma might still cause deep wound infections. The aim of this study was the evaluation of technical modifications of the standard iNPWT dressing to increase seroma evacuation. Methods. iNPWT dressings were applied on the porcine abdominal wall, and an incremental pressure ramp from 50 to 200 mmHg was performed. The resulting wound pressures were measured using (i) balloon manometry and (ii) esophageal manometry catheter. Seroma evacuation was analyzed with a seroma model. All measurements were performed with (i) standard iNPWT dressing, (ii) wound gauze diverted through the incision, and (iii) placement of suction drain tube into iNPWT. Results. Due to the modifications of the iNPWT dressing, the vacuum applied by the iNPWT dressing could be transferred into the wound and was not only restricted to superficial layers. More importantly, placement of wound gauzes or suction drain tubes led to complete extraction of wound seroma. The placement of the suction drain tube showed the best combination of increased intrawound pressure as well as seroma evacuation. Conclusion. Addition of a suction drain tube to the iNPWT dressing leads to an improved function of the iNPWT dressing in our ex vivo model.
C1 [Mehdorn, Matthias; Jansen-Winkeln, Boris] Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Mehdorn, M (通讯作者)，Univ Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, D-04103 Leipzig, Germany.
EM matthias.mehdorn@medizin.uni-leipzig.de
RI Jansen-Winkeln, Boris/KPA-5791-2024
OI Jansen-Winkeln, Boris/0000-0002-3996-9391
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NR 31
TC 5
Z9 5
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD OCT 21
PY 2021
VL 2021
AR 5846724
DI 10.1155/2021/5846724
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA XB7JS
UT WOS:000721502300002
PM 34722767
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Inukai, K
   Usui, A
   Yamada, M
   Amano, K
   Mukai, N
   Tsunetoshi, Y
   Nakata, Y
   Yokota, J
AF Inukai, Koichi
   Usui, Akihiro
   Yamada, Motohiko
   Amano, Koji
   Mukai, Nobutaka
   Tsunetoshi, Yusuke
   Nakata, Yasuki
   Yokota, Junichiro
TI Open abdominal management for perforative peritonitis with septic shock:
   a retrospective analysis on usefulness of a standardized treatment
   protocol
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Damage control surgery; Open abdominal management; Perforative
   peritonitis; Secondary peritonitis; Septic shock
ID SEVERE SEPSIS; OPEN ABDOMEN; INJURY; TRAUMA
AB Background Damage control surgery (DCS) with open abdominal management (OAM) has been increasingly expanded to include critically ill non-trauma patients. However, there is limited data regarding the usefulness of this protocol for the treatment of severe perforative peritonitis (PP), especially with septic shock (SS). Here, we retrospectively evaluated the usefulness of our OAM protocol for PP with SS. Methods We retrospectively reviewed patients with from June 2015 to September 2018. The proposed protocol was composed of the following steps: (1) rapid control of contamination; (2) temporary abdominal closure; (3) repeated washout of the abdominal cavity; and (4) delayed definitive surgery. For temporary abdominal closure, a negative pressure wound therapy device was used. The end points were the morbidity and 30-day mortality rates. Logistic backward regression was performed to identify factors associated with complications. Results The mortality rate was 4% (1/25) and the overall morbidity rate of surviving patients was 58.3% (14/24). The mean duration of the first DCS was 67.36 +/- 22.83 min. The median durations of ventilation and intensive care unit stay were 5 and 7 days, respectively. Although not significant, morbidity might be associated with age, diabetes mellitus, initial operative time, and OAM duration. Conclusions A standardized protocol for OAM may improve the outcomes of patients with SS due to PP. This damage control approach can be applied for the treatment of severe abdominal sepsis.
C1 [Inukai, Koichi; Usui, Akihiro; Yamada, Motohiko; Amano, Koji; Mukai, Nobutaka; Tsunetoshi, Yusuke; Nakata, Yasuki; Yokota, Junichiro] Sakai City Med Ctr, Dept Acute Care Surg, Nishi Ku, 1-1-1 Ebaraji Cho, Sakai, Osaka 5938304, Japan.
RP Inukai, K (通讯作者)，Sakai City Med Ctr, Dept Acute Care Surg, Nishi Ku, 1-1-1 Ebaraji Cho, Sakai, Osaka 5938304, Japan.
EM koichi.sums@gmail.com; a.usui0126@gmail.com; mt1001vv@kjc.biglobe.ne.jp;
   amanyoppy@yahoo.co.jp; surf-nob@wb4.so-net.ne.jp; ytsunetoshi@gmail.com;
   nakata-ya@sakai-hospital.jp; yokota-j@sakai-hospital.jp
RI Inukai, Koichi/KYQ-8809-2024
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NR 29
TC 4
Z9 7
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2021
VL 47
IS 1
SI SI
BP 93
EP 98
DI 10.1007/s00068-019-01132-2
PG 6
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA QA9JI
UT WOS:000613758600012
PM 30949740
DA 2026-07-24
ER

PT J
AU Glaser, DA
   Farnsworth, CL
   Varley, ES
   Nunn, TA
   Sayad-Shah, M
   Breisch, EA
   Yaszay, B
AF Glaser, Diana A.
   Farnsworth, Christine L.
   Varley, Eric S.
   Nunn, Thomas A.
   Sayad-Shah, Mehria
   Breisch, Eric A.
   Yaszay, Burt
TI Negative Pressure Therapy for Closed Spine Incisions: A Pilot Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS; WOUND
   INFECTIONS; MANAGEMENT; RESISTANCE; PIG
AB Negative pressure therapy (NPT), used on open wounds or postoperative infections, has not been evaluated on closed spinal incisions. This was analyzed after 3 days and 5 days of NPT application using biomechanics and histology in a porcine model. Methods. In, 8 mature miniature pigs, 2 end-to-end midline spine incisions were closed in a standard fashion. Negative pressure (Prevena (TM) Incision Management System, KCI, San Antonio, TX) was applied to one incision.(NPT group) while standard dry dressings were used on the other (control group). After 3 days or 5 days, all incisions underwent biomechanical (eg, failure load, failure energy, and stress), histological, and scar scale evaluation Analysis. ANOVAs compared the groups (3 day vs 5-day, NPT vs control, P < 0.05). Negative pressure therapy demonstrated a significantly improved scar scale height grade than the control (P = 0.026). Failure load (4.9 +/- 4.0 vs 16.5 +/- 14.6 N), energy. absorbed (8.0 +/- 9.0 vs 26.9 +/- 23.0 mJ), and ultimate stress (62 +/- 53 vs. 204 +/- 11.8 N/mm(2)) were lower in the control group. Histological analysis revealed no differences in incision scar width. Conclusion. Negative pressure therapy application on closed. incisions presented, a trend toward improved;early healing strength, and in significantly improved incision appearance. Clinically, NPT may improve incision. integrity minimizing the risk of dehiscence or subsequent infection. Patients at high risk of postoperative incision site complications may. benefit from primary application of NPT.
C1 [Glaser, Diana A.; Farnsworth, Christine L.; Nunn, Thomas A.; Breisch, Eric A.; Yaszay, Burt] Rady Childrens Hosp, Orthoped Biomech Res Ctr, San Diego, CA USA.
   [Varley, Eric S.; Sayad-Shah, Mehria] Univ Calif San Diego, Dept Orthopaed Surg, San Diego, CA 92103 USA.
C3 Rady Childrens Hospital San Diego; University of California System;
   University of California San Diego
RP Farnsworth, CL (通讯作者)，Childrens Specialists San Diego, Dept Orthoped Res, 3020 Childrens Way,MC 5054, San Diego, CA 92123 USA.
EM cfarnsworth@rchsd.org
RI Farnsworth, Christine/Q-5617-2018
OI Farnsworth, Christine/0000-0001-7615-3749
FU KCI Medical, San Antonio,TX; KCI Medical, Inc
FX This study was supported by a research grant from KCI Medical, San
   Antonio,TX.The authors would like to recognize and thank Tracey Bastrom,
   MA, for statistical analysis; JD Bomar for figure development; and KCI
   Medical, Inc for research support.
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NR 28
TC 33
Z9 36
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2012
VL 24
IS 11
BP 308
EP 316
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 048NK
UT WOS:000311919000002
PM 25876166
DA 2026-07-24
ER

PT J
AU Trueman, P
   Flack, S
   Loonstra, A
   Hauser, T
AF Trueman, Paul
   Flack, Sarah
   Loonstra, Ate
   Hauser, Tino
TI The feasibility of using VAC® Therapy in home care patients with
   surgical and traumatic wounds in the Netherlands
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Home care; Surgical; Trauma; VAC; Wounds
AB The aim of this study was to review the feasibility of using vacuum-assisted closure (V.A.C.(R)) Therapy for the management of surgical and traumatic wounds in the home care settings in the Netherlands. De-identified patient data were collected from a health insurance database in the Netherlands. All patients with complete records, including indication, age, duration of therapy and defined treatment goal between January and November 2006 were included. Data from 338 patients were analysed. On average, wounds had been present for 2 months before start of V. A. C. Therapy. Overall, 74% of patients reached the pre-defined therapy goal (77% for dehisced wounds, 68% for abdominal wounds, 73% for traumatic wounds and 91% for sternal wounds) with approximately 1 month of V. A. C. Therapy. There was a negative association between the wound duration prior to V.A.C. Therapy and the treatment success rate (r = -0.162, P = 0.003). Wounds with shorter duration (< 4 weeks) prior to initiation of V. A. C. Therapy achieved an 82% success rate compared with 33% for wounds present for > 6 months prior to V. A. C. Therapy. V. A. C. Therapy is a feasible and effective treatment for surgical and traumatic wounds in home care patients with over 70% of patients treated in this sample achieving pre-defined treatment goals. The success rate of V. A. C. Therapy is negatively associated with the duration of the wound before V. A. C. Therapy is commenced.
C1 [Trueman, Paul; Flack, Sarah] Univ York, York Hlth Econ Consortium, York YO10 5NH, N Yorkshire, England.
   [Loonstra, Ate; Hauser, Tino] KCI Europe Holding BV, Amstelveen, Netherlands.
C3 University of York - UK
RP Trueman, P (通讯作者)，Univ York, York Hlth Econ Consortium, Market Sq,Vanbrugh Way, York YO10 5NH, N Yorkshire, England.
EM pt507@york.ac.uk
FU KCI Medical
FX This research was supported by funding from KCI Medical. PT has received
   institutional funding from KCI Medical to support previous research. The
   remaining authors have no potential conflicts to declare.
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NR 29
TC 4
Z9 6
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 225
EP 231
DI 10.1111/j.1742-481X.2008.00472.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500011
PM 18494628
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Krasowski, G
   Jawien, A
   Tukiendorf, A
   Rybak, Z
   Junka, A
   Olejniczak-Nowakowska, M
   Bartoszewicz, M
   Smutnicka, D
AF Krasowski, Grzegorz
   Jawien, Arkadiusz
   Tukiendorf, Andrzej
   Rybak, Zbigniew
   Junka, Adam
   Olejniczak-Nowakowska, Malgorzata
   Bartoszewicz, Marzenna
   Smutnicka, Danuta
TI A comparison of an antibacterial sandwich dressing vs dressing
   containing silver
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS;
   CARE; SYSTEM; DEVICE; TRIAL
AB The purpose of this study was to compare the efficacy of dressings containing octenidine vs. dressings containing silver in the wound healing in the course of a chronic venous disease. There were two groups of 40 patients who met the inclusion criteria and who did not meet the exclusion criteria. The patients were randomly assigned into the groups (envelope method). The first, "O group" was treated with octenidine-based dressings. The second, "S group" was treated with silver dressings. The study lasted for 56 days. All patients in the research were treated with medical compression stockings with cotton understockings. Microbiological eradication was observed on the 28th day of the study among 33% of patients in the treatment group vs. 6% in control group. On the 56th day of the treatment, these percentages equalled 72% and 35%. The rate of healing was faster in the 0 group than in the S group. In the wounds < 10 cm(2) it was faster by 1.35 cm(2)/week and in wounds > 10 cm(2) it equalled 3.44 cm(2). The reduction of pain level was 37.5% higher in the O group, in contrast with the S group. One change of a dressing in the O group led to a 0.06 cm(2) greater wound size reduction and in the case of wounds > 10 cm(2) to 0.29 cm(2) reduction compared with the S group. The presented results indicate that the efficacy of dressings containing octenidine is higher compared to silver dressings.
C1 [Krasowski, Grzegorz] KCZ Surg Ward, Nutrikon, Krapkowice, Poland.
   [Jawien, Arkadiusz] Univ Hosp 1 Bydgoszcz, Dept Vasc Surg & Angiol Collegium Med Bydgoszc, Bydgoszcz, Poland.
   [Tukiendorf, Andrzej] Ctr Oncol, Inst Gliwice, Dept Epidemiol, Gliwice, Poland.
   [Junka, Adam] Wroclaw Med Univ, Dept Pharmaceut Microbiol & Parasitol, Wroclaw, Poland.
   [Olejniczak-Nowakowska, Malgorzata] Silesian Med Univ, Dept Publ Hlth, Bytom, Czech Republic.
   [Smutnicka, Danuta] Wroclaw Med Univ, Pharmaceut Microbiol & Parasitol, Wroclaw, Poland.
C3 Nicolaus Copernicus University; Wroclaw Medical University; Medical
   University of Silesia; Wroclaw Medical University
RP Krasowski, G (通讯作者)，Sp Zoo, Nutrikon, Ul Browicka 10, PL-46050 Walidrogi, Poland.
EM g.krasowski@wp.pl
RI Rybak, Zbigniew/AAV-9651-2021; Tukiendorf, Andrzej/AED-2415-2022;
   Jawien, Arkadiusz/L-1475-2014
OI Rybak, Zbigniew/0000-0002-1906-6435; Junka, Adam/0000-0002-7559-8903;
   Jawien, Arkadiusz/0000-0001-8380-9371; Tukiendorf,
   Anzej/0000-0001-5278-989X; BARTOSZEWICZ, MARZENNA/0000-0002-6542-2525
CR Agency for Healthcare Research and Quality, 2013, GRAD STRENGTH BOD EV
   [Anonymous], 2008, COCHRANE DATABASE SY
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NR 41
TC 17
Z9 19
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2015
VL 23
IS 4
BP 525
EP 530
DI 10.1111/wrr.12301
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA CQ7EG
UT WOS:000360765100176
PM 25899420
DA 2026-07-24
ER

PT J
AU Jansen, KT
   Hetzel, J
   Schulte, C
   Düzenli, N
   Fusco, S
   Zerabruck, E
   Schmider, E
   Malek, NP
   Königsrainer, A
   Stüker, D
   Werner, CR
   Wichmann, D
AF Jansen, Kai Tobias
   Hetzel, Juergen
   Schulte, Carola
   Duezenli, Nurgul
   Fusco, Stefano
   Zerabruck, Emanuel
   Schmider, Eva
   Malek, Nisar P.
   Koenigsrainer, Alfred
   Stueker, Dietmar
   Werner, Christoph R.
   Wichmann, Doerte
TI Differences in fluid removal of different open-pore elements for
   endoscopic negative pressure therapy in the upper gastrointestinal tract
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE; DRAINAGE
AB Endoscopic negative pressure therapy is an effective treatment strategy for various defects of the gastrointestinal tract. The functional principle is based on an open-pore element, which is placed around a perforated drainage tube and connected to a vacuum source. The resulting open-pore suction device can undergo endoluminal or intracavitary placement. Different open-pore suction devices are used for endoscopic negative pressure therapy of upper gastrointestinal tract defects. Comparative analyses for features and properties of these devices are still lacking. Eight different (six hand-made devices and two commercial devices) open-pore suction devices for endoscopic negative pressure therapy of the upper gastrointestinal tract were used, amount fluid removed was evaluated. The evaluation parameters included the time to reach the target pressure, the time required to remove 100 ml of water, and the material resistance of the device. All open-pore suction devices are able to aspirate the target volume of fluids. The time to reach the target volume varied considerably. Target negative pressure was not achieved with all open-pore suction devices during the aspiration of fluids; however, there was no negative effect on suction efficiency. Of the measurement data, material resistance could be calculated for six open-pore elements. We present a simple experimental, nonphysiologically setup for open-pore suction devices used for endoscopic negative pressure therapy. The expected quantity of fluids secreted into the treated organs should affect open-pore suction device for endoscopic negative pressure therapy.
C1 [Jansen, Kai Tobias; Schulte, Carola; Duezenli, Nurgul; Koenigsrainer, Alfred; Stueker, Dietmar; Wichmann, Doerte] Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Hetzel, Juergen] Univ Hosp Tubingen, Dept Internal Med Pulmonol & Oncol 8, Otfried Muller Str 10, D-72076 Tubingen, Germany.
   [Hetzel, Juergen] Cantonal Hosp Winterthur, Dept Internal Med, Devis Pulmonol, Brauer Str 15, CH-8400 Winterthur, Switzerland.
   [Fusco, Stefano; Malek, Nisar P.; Werner, Christoph R.] Univ Hosp Tubingen, Dept Internal Med Gastroenterol Hepatol Gastroint, Otfried Mueller Str 10, D-72076 Tubingen, Germany.
   [Hetzel, Juergen; Fusco, Stefano; Zerabruck, Emanuel; Schmider, Eva; Malek, Nisar P.; Koenigsrainer, Alfred; Stueker, Dietmar; Werner, Christoph R.; Wichmann, Doerte] Univ Hosp Tubingen, Interdisciplinary Endoscop Unit, Hoppe Seyler Str 6, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital; Eberhard Karls University of Tubingen; Eberhard
   Karls University Hospital; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital
RP Werner, CR (通讯作者)，Univ Hosp Tubingen, Dept Internal Med Gastroenterol Hepatol Gastroint, Otfried Mueller Str 10, D-72076 Tubingen, Germany.; Werner, CR (通讯作者)，Univ Hosp Tubingen, Interdisciplinary Endoscop Unit, Hoppe Seyler Str 6, D-72076 Tubingen, Germany.
EM christoph.werner@med.uni-tuebingen.de
RI ; Fusco, Stefano/JYQ-3117-2024
OI Hetzel, Juergen/0009-0008-7668-0723; Fusco, Stefano/0000-0001-6093-4567
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 20
TC 5
Z9 7
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 16
PY 2022
VL 12
IS 1
AR 13889
DI 10.1038/s41598-022-17700-3
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3V1BY
UT WOS:000841397200025
PM 35974057
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Calibre, C
   Bouhanna, A
   Salmin, JP
   Bodin, F
   Benaïssa-Beck, M
   Bruant-Rodier, C
AF Calibre, C.
   Bouhanna, A.
   Salmin, J. -P.
   Bodin, F.
   Benaissa-Beck, M.
   Bruant-Rodier, C.
TI Axillary hidradenitis suppurativa: A single-stage surgical treatment
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Axillary hidradenitis suppurativa; Negative-pressure dressings; Surgical
   treatment
ID NEGATIVE-PRESSURE DRESSINGS; VACUUM-ASSISTED CLOSURE; SECURING
   SKIN-GRAFTS; WOUND CONTROL; EXCISION; FLAP
AB Introduction. - Hidradenitis suppurativa is a chronic inflammatory disease, particularly incapacitating. Wide surgical excision of the whole affected skin is the only radical and successful treatment that can be offered. Coverage of the defect is then generally obtained with a split-thickness skin graft after a period of granulation. We expose a single-stage procedure which reduces the number of surgical times and the period of recovery.
   Patients and methods. - We have documented a series of five patients who underwent uni(three cases) or bilateral (two cases) axillary hidradenitis suppurativa, between December 2008 and December 2009. Surgical procedure included excision of the lesions and coverage with a split-thickness skin graft. The graft was meshed in a ratio of 1.5:1, and secured with a negative-pressure dressing. This dressing, which provided a continuous subatmospheric pressure of -75 mmHg, was removed after five days. Then, complete healing was obtained with conventional vaseline gauze dressings.
   Results. - After removal of the negative-pressure dressings, the graft take was 90% on average (80-100%). Complete healing was obtained within an average of 34 days (20-43 days), with a good quality of scar tissue, no retraction and no limitation of arm's abduction.
   Conclusion. - This technique, enabled by negative-pressure dressings, provides a quick and good quality healing, with only one surgical stage. It has many advantages: reduced morbidity, faster healing, higher level of patient's comfort, and lower costs. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Calibre, C.] CHRU Lille, Hop Roger Salengro, Ctr Brules, Serv Chirurg Plast & Reconstructrice, F-59037 Lille, France.
   [Bouhanna, A.; Salmin, J. -P.; Bodin, F.; Benaissa-Beck, M.; Bruant-Rodier, C.] Hop Civil, Serv Chirurg Maxillofaciale Plast & Reconstructri, F-67000 Strasbourg, France.
C3 Universite de Lille; CHU Lille; CHU Strasbourg
RP Calibre, C (通讯作者)，CHRU Lille, Hop Roger Salengro, Ctr Brules, Serv Chirurg Plast & Reconstructrice, F-59037 Lille, France.
EM clotildecalibre@yahoo.fr
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NR 29
TC 12
Z9 12
U1 0
U2 0
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD DEC
PY 2013
VL 58
IS 6
BP 670
EP 675
DI 10.1016/j.anplas.2011.05.004
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 259QW
UT WOS:000327542400008
PM 21757281
DA 2026-07-24
ER

PT J
AU Richter, F
   Ellrichmann, M
AF Richter, Florian
   Ellrichmann, Mark
TI Endoscopic Treatment of Anastomotic Leakage in the Upper
   Gastrointestinal Tract
SO VISCERAL MEDICINE
LA English
DT Review
DE Anastomotic leakage; Upper gastrointestinal tract; Endoscopy; Endoscopic
   vacuum therapy
ID VACUUM-ASSISTED CLOSURE; EXPANDABLE METAL STENTS; SCOPE CLIPPING DEVICE;
   MULTICENTER EXPERIENCE; ESOPHAGEAL RESECTION; MANAGEMENT; THERAPY;
   DRAINAGE; DEFECTS; COMPLICATIONS
AB Background: Anastomotic leakage (AL) in the upper gastrointestinal tract (uGIT) is a critical condition associated with high mortality and significant morbidity. Effective management requires prompt and specialized diagnostic and therapeutic interventions through an interdisciplinary approach. In current practice, surgical intervention is infrequent and typically reserved for cases of extensive damage. Close collaboration between radiology, endoscopy, and surgery is essential for optimal care. Endoscopic therapy is the primary modality for managing AI in the upper GIT. This review offers an overview of the most common endoscopic treatment strategies for AL in this region. Summary: Significant advancements have been made in the endoscopic management of AL in the uGIT in recent years. Endoscopic sutures and clips remain appropriate for smaller defects, but for larger leakages, endoscopic vacuum therapy (EVT) is gaining prominence over stent placement. Innovative approaches, such as vacuum stents and small diameter filmed drainage (FD), offer promising new therapeutic options for treating AL in the uGIT. Key Messages: (1) Endoscopy plays a pivotal role in the management of AL in the upper GIT. (2) A growing body of evidence supports EVT as superior to other modalities such as sutures, tissue sealants, or clips. Notably, EVT has a lower complication rate and higher healing success compared to stent therapy in AL treatment. (3) New endoscopic techniques, including the vacuum stent and FD, represent promising advancements in the treatment of AL.
C1 [Richter, Florian] Univ Med Ctr Schleswig Holstein UKSH, Dept Gen Visceral Thorac Transplantat & Paediat S, Campus Kiel, Kiel, Germany.
   [Ellrichmann, Mark] Univ Med Ctr Schleswig Holstein UKSH, Med Dept 1, Interdisciplinary Endoscopy, Campus Kiel, Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Ellrichmann, M (通讯作者)，Univ Med Ctr Schleswig Holstein UKSH, Med Dept 1, Interdisciplinary Endoscopy, Campus Kiel, Kiel, Germany.
EM mark.ellrichmann@uksh.de
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NR 72
TC 0
Z9 0
U1 1
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2297-4725
EI 2297-475X
J9 VISC MED
JI Visc. Med.
PD AUG
PY 2025
VL 41
IS 4
BP 182
EP 190
DI 10.1159/000545485
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 6IR4A
UT WOS:001554286100001
PM 40376231
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Nishimura, K
   Blume, P
   Ohgi, S
   Sumpio, BE
AF Nishimura, Kengo
   Blume, Peter
   Ohgi, Shigetsugu
   Sumpio, Bauer E.
TI Effect of different frequencies of tensile strain on human dermal
   fibroblast proliferation and survival
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; P38 MAP KINASE; ACTIVATED PROTEIN-KINASES;
   PRESSURE WOUND THERAPY; ENDOTHELIAL-CELLS; CYCLIC STRAIN;
   PHOSPHATIDYLINOSITOL 3-KINASE; TYROSINE PHOSPHORYLATION;
   SUBSTRATE-SPECIFICITY; HUMAN KERATINOCYTES
AB The aim of this study is to compare the effect of a high-frequency repetitive (HF) stretch or an intermittent (I) stretch on the cell proliferation and survival of human dermal fibroblasts and to determine the activation of any relevant signal pathways. Cultured human dermal fibroblasts were exposed to either HF or I stretch. Cell number was measured by counting, while DNA synthesis was assessed by 5-bromo-2'-deoxyuridine (BrdU) staining and apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining. To investigate the potential mechanisms of repetitive strain on the proliferation and survival of fibroblasts, the activation of relevant transduction pathways, such as p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK)1/2, AKT, and BAD, was assessed by Western blot. In addition, the effect of inhibition of these pathways on the fibroblast response was also studied. After either HF or I stretch for 7 days, fibroblast number was significantly decreased and there were less BrdU-positive cells. The numbers of apoptotic and/or necrotic fibroblasts were not affected. p38 MAPK and ERK1/2 were significantly activated after HF stretch, but AKT and BAD were significantly activated after I stretch. The inhibitors of p38 MAPK and MAPK/ERK kinase as well as dominant-negative AKT reduced cell number after both HF and I stretch but these pathways were not critical for the stretch-induced decrease in cell number.
C1 Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   Tottori Univ, Fac Med, Dept Surg, Yonago, Tottori 683, Japan.
C3 Yale University; Tottori University
RP Sumpio, BE (通讯作者)，Yale Univ, Sch Med, Dept Surg, 333 Cedar St,FMB 137, New Haven, CT 06520 USA.
EM bauer.sumpio@yale.edu
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NR 41
TC 42
Z9 47
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP-OCT
PY 2007
VL 15
IS 5
BP 646
EP 656
DI 10.1111/j.1524-475X.2007.00295.x
PG 11
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 215ZF
UT WOS:000249846800006
PM 17971010
DA 2026-07-24
ER

PT J
AU Garayua-Cruz, L
   Broida, SE
   Sullivan, MH
   Folpe, AL
   Welliver, MX
   Lee, KN
   Siontis, BL
   Robinson, SI
   Ho, TP
   Okuno, SH
   Rose, PS
   Bakri, K
   Moran, SL
   Houdek, MT
AF Garayua-Cruz, Leilani
   Broida, Samuel E.
   Sullivan, Mikaela H.
   Folpe, Andrew L.
   Welliver, Meng X.
   Lee, Katie N.
   Siontis, Brittany L.
   Robinson, Steven I.
   Ho, Thanh P.
   Okuno, Scott H.
   Rose, Peter S.
   Bakri, Karim
   Moran, Steven L.
   Houdek, Matthew T.
TI Staged Reconstruction Is Not Necessary Following Oncologic Resection of
   Superficial Myxofibrosarcoma
SO CANCERS
LA English
DT Article
DE myxofibrosarcoma; VAC therapy; recurrence; staged reconstruction
ID EXPERIENCE; EXTREMITY
AB Background: Myxofibrosarcomas are notoriously highly infiltrative soft-tissue sarcomas, making negative surgical margins difficult to obtain. Recently, vacuum-assisted closure (VAC) is used to delay wound closure until a negative margin has been achieved; however, this can delay care and increase costs. Our institution has historically performed single-stage resections with intraoperative frozen margin analysis and reconstruction in these patients. The purpose of this study is to report the outcomes of this technique. Methods: We reviewed 112 patients (62 males, mean age 70 +/- 14 years) with superficial myxofibrosarcoma. Eighty-eight patients received preoperative radiation. All patients underwent surgical resection with intraoperative frozen margin analysis, and the planned reconstruction was performed in a single anesthetic. Results: The 10-year local recurrence-free survival was 90%; positive intraoperative frozen section (HR 7.44, p = 0.004) and final permanent margins (HR 8.53, p = 0.007) were associated with local recurrence. Intraoperative margins were negative in 103 (92%) of patients, 1 of which was positive on final permanent section. There were nine cases of microscopically positive margins, of which seven underwent immediate re-excision to a negative margin. The accuracy of frozen margin assessment for myxofibrosarcoma was between 92.92 and 98.23%. All patients underwent reconstruction at the time of resection, with 19% needing an additional procedure, most commonly due to a wound complication (12%). Conclusions: Multidisciplinary single-stage excision with intraoperative frozen margin assessment and soft-tissue reconstruction yields low rates of local recurrence in patients with superficial myxofibrosarcoma.
C1 [Garayua-Cruz, Leilani] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA.
   [Broida, Samuel E.; Sullivan, Mikaela H.; Rose, Peter S.; Houdek, Matthew T.] Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
   [Folpe, Andrew L.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   [Welliver, Meng X.; Lee, Katie N.] Mayo Clin, Dept Radiat Oncol, Rochester, MN 55905 USA.
   [Siontis, Brittany L.; Robinson, Steven I.; Ho, Thanh P.; Okuno, Scott H.] Mayo Clin, Dept Med Oncol, Rochester, MN 55905 USA.
   [Bakri, Karim; Moran, Steven L.] Mayo Clin, Div Plast & Reconstruct Surg, Rochester, MN 55905 USA.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Houdek, MT (通讯作者)，Mayo Clin, Dept Orthoped Surg, Rochester, MN 55905 USA.
EM houdek.matthew@mayo.edu
RI Houdek, Matthew/AGK-3443-2022; Moran, Steven/MZS-1312-2025
OI Houdek, Matthew/0000-0003-0390-1018; Broida, Samuel/0000-0002-4192-4133;
   Welliver, Meng/0000-0002-8747-692X; 
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NR 26
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV 12
PY 2025
VL 17
IS 22
AR 3637
DI 10.3390/cancers17223637
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA F4762
UT WOS:001623579700001
PM 41301004
OA gold
DA 2026-07-24
ER

PT J
AU Gompelman, M
   van Asten, SAV
   Peters, EJG
AF Gompelman, Michelle
   van Asten, Suzanne A. V.
   Peters, Edgar J. G.
TI Update on the Role of Infection and Biofilms in Wound Healing:
   Pathophysiology and Treatment
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RESISTANT STAPHYLOCOCCUS-AUREUS; DIABETIC FOOT INFECTIONS;
   VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE; IN-VITRO; BACTERIA; THERAPY;
   SKIN; DEBRIDEMENT; IDENTIFICATION
AB Background: Chronic wounds, and among these infected diabetic foot ulcers, are a worldwide problem. The poor treatment outcomes result in high healthcare costs, amputations, a decreased quality of life, and an increased mortality. These outcomes are influenced by several factors, including biofilm formation. A biofilm consists of pathogenic bacteria that are encased in an exopolysaccharide layer and communicate through secretion of signaling molecules. Bacteria that live in a biofilm are refractory to host responses and treatment.
   Methods: We performed a nonsystematic review of the currently published to-date medical biofilm literature. The review summarizes the evidence of biofilm in chronic wounds, the role of biofilm in wound healing, detection of biofilm, and available antibiofilm treatments. Articles containing basic science and clinical research, as well as systematic reviews, are described and evaluated. The articles have variable levels of evidence. All articles have been peer reviewed and meet the standards of evidence-based medicine.
   Results: Both animal and human studies have identified biofilm in chronic wounds and have suggested that healing might be influenced by its presence. A promising development in biofilm detection is rapid molecular diagnostics combined with direct microscopy. This technique, rather than classic culture, might support individualized treatment in the near future. A wide range of treatments for chronic wounds also influence biofilm formation. Several agents that specifically target biofilm are currently being researched.
   Conclusions: Biofilm formation has a substantial role in chronic wounds. Several diagnostic and therapeutic methods against biofilm are currently being developed.
C1 [Peters, Edgar J. G.] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, Room ZH 4A35,POB 7057, NL-1007 MB Amsterdam, Netherlands.
   Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
C3 Vrije Universiteit Amsterdam; University of Texas System; University of
   Texas Southwestern Medical Center
RP Peters, EJG (通讯作者)，Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, Room ZH 4A35,POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM e.peters@vumc.nl
RI Van Asten, Suzanne/OYE-3899-2025; Peters, Edgar/B-7790-2014; Gompelman,
   Michelle/H-2503-2017
OI van Asten, Suzanne/0000-0002-2753-4577; Peters,
   Edgar/0000-0002-3410-1227; Gompelman, Michelle/0000-0002-8568-5437
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NR 97
TC 53
Z9 58
U1 1
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 61S
EP 70S
DI 10.1097/PRS.0000000000002679
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300009
PM 27556776
DA 2026-07-24
ER

PT J
AU Khurram, MF
   Ali, SS
   Yaseen, M
AF Khurram, Mohammed Fahud
   Ali, Sheikh Sarfraz
   Yaseen, Mohammad
TI Vacuum-Assisted Wound Closure Therapy in Pediatric Lower Limb Trauma
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE skin graft; wound management; wound care; dressings; NPWT; TNP;
   debridement
ID MANAGEMENT; FRACTURES
AB Although the importance of vacuum-assisted wound closure therapy has been well established as road to definitive treatment of trauma wound in the adult population, its use in pediatric patients is not well described in the literature. This study was conducted to evaluate the outcome of vacuum-assisted wound closure therapy in pediatric patients. Twenty-two patients were prospectively treated for soft tissue defect in lower limb using vacuum-assisted wound closure device, as these wounds were not amenable for primary closure. After wound evaluation, thorough wound debridement was done. Vacuum-assisted wound closure dressing was applied once hemostasis was achieved. Dressings were changed as per protocol. After the development of healthy granulation tissue, wound coverage was achieved with skin graft or flaps. Mean age of patients was 9.455 years, ranging from 4 to 14 years. Early, healthy granulation tissue had formed in all patients. The average number of vacuum-assisted closure (VAC) dressings required was 2.682. Average duration of VAC therapy was 8.045 days. The sizes of soft tissue defects reduced from an average 69.18 cm(2) to 50.73 cm(2) after VAC therapy with a mean decrease of 26.66%. There was no complication because of VAC therapy. Vacuum-assisted wound closure therapy accelerated the process of healthy granulation tissue formation, and thus shortened the healing time. VAC therapy lessens the morbidity and pain associated with large wounds in pediatric patients and brings cheer and smile in growing children.
C1 [Khurram, Mohammed Fahud; Ali, Sheikh Sarfraz; Yaseen, Mohammad] Aligarh Muslim Univ, Jawaharlal Nehru Med Coll & Hosp, Aligarh, Uttar Pradesh, India.
C3 Aligarh Muslim University
RP Ali, SS (通讯作者)，St 8, Aligarh 202001, Uttar Pradesh, India.
EM drsheikhsarfrazaliep@gmail.com
RI Sheikh Sarfraz, Ali/AAJ-5196-2021; khurram, mohammed/I-1773-2019
OI Sheikh Sarfraz, Ali/0000-0003-0093-5511; khurram,
   mohammed/0000-0002-3452-0325
CR [Anonymous], 2009, PRINC BEST PRACT VAC
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NR 19
TC 6
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2019
VL 18
IS 3
BP 317
EP 322
DI 10.1177/1534734619857403
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IX9BC
UT WOS:000485981100013
PM 31258007
DA 2026-07-24
ER

PT J
AU Gibrila, J
   Chaput, B
   Boissière, F
   Atlan, M
   Fluieraru, S
   Bekara, F
   Herlin, C
AF Gibrila, J.
   Chaput, B.
   Boissiere, F.
   Atlan, M.
   Fluieraru, S.
   Bekara, F.
   Herlin, C.
TI Radical treatment of hidradenitis suppurativa: Comparison of the use of
   the artificial dermis and pedicled perforator flaps
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Hidradenitis Suppurativa; Verneuil's disease; Artificial dermis; Flap;
   Quality of life
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; 2-STAGE SURGERY;
   MANAGEMENT; BACTERIOLOGY; SMOKING; PATIENT
AB Objectives. - The objective of this study was to compare the use of artificial dermal and perforator flap after radical surgery of severe axillary and perineal hidradenitis suppurativa disease.
   Patients and methods. - The data on postoperative outcomes, scar assessment (POSAS) and quality of life (DLQI, SF-36) were collected during consultation or by phone call. Forty-seven patients were included in our study between January 2015 and September 2017, including 27 patients in the artificial dermal group and 20 patients in the perforator flap group.
   Results. - The quality of life assessment by the SF-36 questionnaire showed a significant increase in quality of life in both groups (P < 0.05), higher in the perforating flap group (P < 0.001). The DLQI questionnaire showed a decrease in the impact of MV on quality of life in both groups, which was greater in the perforator flap group (P < 0.05). The scarring assessment by the POSAS patient and observer questionnaire showed a better overall opinion in the perforator flap group (P < 0.001). In the perforator flap group, the total hospital stay and healing time was shorter (P < 0.001) and the return to work was faster (P < 0.001).
   Conclusion. - The artificial dermis and the perforator flaps are very useful coverage solutions after radical surgery of hidradenitis suppurativa. The use of perforator flaps, however, seems more interesting while simplifying the post-operative course. (C) 2018 Published by Elsevier Masson SAS.
C1 [Gibrila, J.; Boissiere, F.; Fluieraru, S.; Bekara, F.; Herlin, C.] CHU Lapeyronie, Dept Chirurg Plast Reconstructrice Brules Plaies, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
   [Gibrila, J.; Bekara, F.; Herlin, C.] CHU Lapeyronie, Dept Chirurg Plast & Craniofaciale Pediat, F-34295 Montpellier, France.
   [Chaput, B.; Boissiere, F.] CHU Rangueil, Ctr Brules, Serv Chirurg Plast Reconstructrice & Esthet, F-32400 Toulouse, France.
   [Atlan, M.] Hop Tenon, AP HP, Serv Chirurg Plast Reconstructrice & Esthet, F-75020 Paris, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Universite de Toulouse (EPE); CHU de
   Toulouse; Communaute d'universites et etablissements de Toulouse
   (Comue); Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite;
   Hopital Universitaire Tenon - APHP
RP Herlin, C (通讯作者)，CHU Lapeyronie, Dept Chirurg Plast Reconstructrice Brules Plaies, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.; Herlin, C (通讯作者)，CHU Lapeyronie, Dept Chirurg Plast & Craniofaciale Pediat, F-34295 Montpellier, France.
EM drchristianherlin@gmail.com
OI CHAPUT, benoit/0000-0002-8567-3479
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   2011, DERMATOL SURG, V37, P835, DOI DOI 10.1111/J.1524-4725.2011.01961.X
NR 45
TC 5
Z9 7
U1 0
U2 1
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD JUN
PY 2019
VL 64
IS 3
BP 224
EP 236
DI 10.1016/j.anplas.2018.06.013
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HY3NM
UT WOS:000468033300002
PM 30509684
DA 2026-07-24
ER

PT J
AU Arezzo, A
   Verra, M
   Reddavid, R
   Cravero, F
   Bonino, MA
   Morino, M
AF Arezzo, Alberto
   Verra, Mauro
   Reddavid, Rossella
   Cravero, Francesca
   Bonino, Marco Augusto
   Morino, Mario
TI Efficacy of the over-the-scope clip (OTSC) for treatment of colorectal
   postsurgical leaks and fistulas
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Colorectal surgery; Postoperative complications; Anastomotic leak;
   Endoscopic clips; Over-the-scope clip
ID PERFORATIONS; CLOSURE; SURGERY
AB Colorectal postsurgical leaks and fistulas are severe complications that dramatically increase morbidity and mortality. The aim of this study was to evaluate the clinical impact of over-the-scope clip (OTSC) closure to seal the visceral wall in the management of acute and chronic colorectal postsurgical leaks and fistulas.
   We reviewed our prospective series of acute and chronic colorectal postsurgical leaks and fistulas observed between April 2008 and September 2011 and treated by OTSC. Indications were all cases with an orifice < 15 mm in maximum diameter with no extraluminal abscess and luminal stenosis.
   Endoscopic OTSC closure was performed in 14 consecutive patients (mean defect = 9.1 mm in diameter) by means of 10.5- or 12-mm clips, depending on the wall defect diameter. In eight cases, the indication was an acute leak and in six cases a chronic leak, mainly after anterior rectal resection; two cases were complicated by a rectovaginal fistula and in two other cases by a colocutaneous fistula. OTSC treatment was used to complete endoscopic vacuum-assisted closure of a large defect in three cases. The overall success rate was 86 % (12/14): 87 % (7/8) in acute and 83 % (5/6) in chronic cases. No OTSC-related complications occurred. Further surgery was required in one case.
   Endoscopic OTSC closure of colorectal postsurgical leaks and fistulas is a safe technique, with a high success rate in both acute and chronic cases, including rectovaginal and colocutaneous fistulas.
C1 [Arezzo, Alberto; Verra, Mauro; Reddavid, Rossella; Cravero, Francesca; Bonino, Marco Augusto; Morino, Mario] Univ Turin, I-10126 Turin, Italy.
C3 University of Turin
RP Arezzo, A (通讯作者)，Univ Turin, Corso Dogliotti 14, I-10126 Turin, Italy.
EM alberto.arezzo@mac.com
RI Morino, Mario/AAI-6437-2020; Reddavid, Rossella/ABD-9000-2020; Arezzo,
   Alberto/AAB-6552-2020
OI Morino, Mario/0000-0003-4540-1409; Reddavid,
   Rossella/0000-0003-0603-9953; Bonino, Marco Augusto/0000-0002-1462-5322;
   Arezzo, Alberto/0000-0002-2110-4082
CR Bonin Eduardo A, 2010, Curr Gastroenterol Rep, V12, P374, DOI 10.1007/s11894-010-0136-x
   Bruce J, 2001, BJS-BRIT J SURG, V88, P1157, DOI 10.1046/j.0007-1323.2001.01829.x
   Chambers WM, 2004, BEST PRACT RES CL GA, V18, P865, DOI 10.1016/j.bpg.2004.06.026
   Kirschniak A, 2011, SURG ENDOSC, V25, P2901, DOI 10.1007/s00464-011-1640-2
   Manta R, 2011, ENDOSCOPY, V43, P545, DOI 10.1055/s-0030-1256196
   Parodi A, 2010, GASTROINTEST ENDOSC, V72, P881, DOI 10.1016/j.gie.2010.04.006
   Raju GS, 2007, GASTROINTEST ENDOSC, V66, P774, DOI 10.1016/j.gie.2007.04.020
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   Voermans RP, 2011, ENDOSCOPY, V43, P217, DOI 10.1055/s-0030-1256072
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 12
TC 63
Z9 78
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2012
VL 26
IS 11
BP 3330
EP 3333
DI 10.1007/s00464-012-2340-2
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 021IX
UT WOS:000309879600045
PM 22580885
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cecere, F
   Kafka, R
   Maglione, M
   Öfner, D
   Wykypiel, H
AF Cecere, F.
   Kafka, R.
   Maglione, M.
   Oefner, D.
   Wykypiel, H.
TI "The abdominal catastrophe"
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article
DE Short bowel syndrome; Intestinal fistula; Parenteral nutrition;
   Intestinal transplant
ID SHORT-BOWEL SYNDROME; PARENTERAL-NUTRITION; MANAGEMENT; TRANSPLANTATION
AB An open abdomen with multiple small intestinal fistulas is a highly challenging situation for the entire treating team and, in some cases, ultimately requires small bowel transplantation.
   In May 2015, a 55-year-old female patient was transferred to our department for evaluation for small bowel transplantation. Following appendectomy in childhood, the patient had had a complicated course with consecutive loss of small bowel. In May 2014, an even more complicated perforated sigma diverticulitis followed. The consequence was a small bowel high-output stoma with concomitant short-bowel syndrome. In March 2015, an attempt to reconstruct the passage failed and ended in an open abdomen with eight small intestinal fistulae, a contracted ileostomy and a defunctioned descendostomy. We firstly mobilized the stoma and conditioned the wound with almost daily changing of a vacuum dressing system (VACA (R), KCI, International) by using a children's pacifier. At 6 months after the previous abdominal operation, extensive adhesiolysis and conglomerate resection plus a jejunoileostomy and new installation of the descendostomy was performed. Approximately 80 cm of small intestine, 50 cm of colon plus the ileocecal valve could be preserved. The abdominal wall was closed cutaneously only. After 168 days of hospitalization, the patient was discharged with oral alimentation and supplementary parenteral nutrition only by night.
   With considerable nursing and surgical effort, the need for intestinal transplantation with all its complications can be avoided in selected cases. A children's pacifier can help to make vacuum-assisted closure of the wound possible.
C1 [Cecere, F.; Kafka, R.; Maglione, M.; Oefner, D.; Wykypiel, H.] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Cecere, F (通讯作者)，Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Innsbruck, Austria.
EM federico.cecere@tirol-kliniken.at
RI Öfner, Dietmar/JJF-9514-2023; Maglione, Manuel/AAK-8599-2020
CR Abu-Elmagd KM, 2009, TRANSPLANTATION, V88, P926, DOI 10.1097/TP.0b013e3181b7509c
   [Anonymous], 2000, ACTA CHIRURG AUSTRIA
   [Anonymous], OPTN SRTR 2011 ANN D
   Di Saverio S, 2016, LANGENBECK ARCH SURG, V401, P1, DOI 10.1007/s00423-015-1370-3
   Di Saverio S, 2011, J TRAUMA, V71, P760, DOI 10.1097/TA.0b013e318216e340
   Dünser M, 2017, EUR SURG, V49, P41, DOI 10.1007/s10353-016-0455-8
   Florescu DF, 2001, PEDIATR INFECT DIS J, V31, P700
   Fronek J, 2016, EUR SURG, V48, pS130, DOI 10.1007/s10353-016-0403-7
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   Paliogiannis P, 2016, EUR SURG, V48, P18, DOI 10.1007/s10353-015-0356-2
   Perathoner A, 2015, EUR SURG, V47, P359, DOI 10.1007/s10353-015-0368-y
   Pironi L, 2011, GUT, V60, P17, DOI 10.1136/gut.2010.223255
   Weng CC, 2015, ASIA PAC J CLIN NUTR, V24, P184, DOI 10.6133/apjcn.2015.24.1.06
NR 18
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2017
VL 49
IS 6
BP 293
EP 297
DI 10.1007/s10353-017-0490-0
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FP6HJ
UT WOS:000417725600009
DA 2026-07-24
ER

PT J
AU Wrzesniak, Z
   Wilk, B
   Pulik, L
   Guzik, G
   Legosz, P
AF Wrzesniak, Zofia
   Wilk, Bartlomiej
   Pulik, Lukasz
   Guzik, Grzegorz
   Legosz, Pawel
TI Optimizing Outcomes in Total Femur Replacement: Complications,
   Management Strategies, and Lessons Learned
SO MEDICINA-LITHUANIA
LA English
DT Article
DE total femur replacement; arthroplasty; endoprosthesis
ID SALVAGE; ARTHROPLASTY; FAILURE
AB Background and Objectives: Total femoral replacement (TFR) was originally developed for limb salvage following the resection of malignant tumors. Over time, its indications have expanded, now serving as a reconstructive option for failed endoprosthetic replacements and severe trauma cases. Despite its advantages, TFR is a highly complex surgical procedure associated with significant complication rates. This study aims to analyze the management of complications and propose strategies to mitigate associated risks. Materials and Methods: This is a retrospective study conducted on patients from two independent hospitals who underwent TFR for different reasons. Results: Nineteen patients were included: eight underwent TFR for oncological indications, while 11 had the procedure as a revision following failed endoprosthetic arthroplasty or trauma. Postoperative complications were observed in 10 patients (53%), including hip dislocation (21%), mechanical implant failure (11%), infection (21%), wound healing complications (26%), and metal allergy symptoms (5%). Revision surgery was required in six patients (32%), but no cases necessitated amputation. Conclusions: TFR is associated with a high risk of complications, with infection and wound healing issues being the most prevalent. In our experience effective complication management strategies should include early intervention, considering TFR at an earlier stage in non-oncological patients to minimize multiple revision surgeries; allergy screening, assessing for potential metal hypersensitivity preoperatively; dislocation prevention, implementing dual mobility bearings to reduce instability; infection control, utilizing intraoperative local antibiotic therapy in revision cases; and wound management, applying vacuum-assisted closure (VAC) therapy postoperatively to enhance wound healing. Implementing these strategies may improve patient outcomes and reduce the burden of complications associated with TFR.
C1 [Wrzesniak, Zofia; Wilk, Bartlomiej] Med Univ Warsaw, Fac Med, Zwirki i Wigury 61, PL-02091 Warsaw, Poland.
   [Pulik, Lukasz; Legosz, Pawel] Med Univ Warsaw, Dept Orthopaed & Traumatol, Ul Lindleya 4, PL-02005 Warsaw, Poland.
   [Guzik, Grzegorz] Podkarpacki Reg Oncol Ctr, Oncol Orthopaed Dept, Ul Ks Jozefa Bielawskiego 18, PL-36200 Brzozow, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Wrzesniak, Z (通讯作者)，Med Univ Warsaw, Fac Med, Zwirki i Wigury 61, PL-02091 Warsaw, Poland.
EM zofia.wrzesniak@wp.pl; wilk.wilkbartlomiej@gmail.com;
   lukasz.pulik@wum.edu.pl; grzegorz.guzik@vp.pl; pawel.legosz@wum.edu.pl
RI Łęgosz, Paweł/ABB-5424-2020; Pulik, Łukasz/AAI-7943-2020
CR Adzhar AL, 2023, MALAYS ORTHOP J, V17, P21, DOI 10.5704/MOJ.2307.004
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   Guerra J, 2021, GERIATR ORTHOP SURG, V12, DOI 10.1177/21514593211019977
   Henderson ER, 2020, J BONE JOINT SURG AM, V102, P1511, DOI 10.2106/JBJS.19.01022
   Hoveidaei AH, 2024, ANN MED SURG, V86, P1641, DOI 10.1097/MS9.0000000000001085
   Idris N, 2023, BMC MUSCULOSKEL DIS, V24, DOI 10.1186/s12891-023-06643-z
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   Mori T, 2024, CLIN ORTHOP RELAT R, V482, P702, DOI 10.1097/CORR.0000000000002874
   Murray J, 2023, BONE JOINT J, V105B, P888, DOI 10.1302/0301-620X.105B8.BJJ-2022-1372.R1
   Putman S, 2019, ORTHOP TRAUMATOL-SUR, V105, P591, DOI 10.1016/j.otsr.2018.12.013
   Ramanathan D, 2015, WORLD J ORTHOP, V6, P919, DOI 10.5312/wjo.v6.i11.919
   Sevelda F, 2015, CLIN ORTHOP RELAT R, V473, P2079, DOI 10.1007/s11999-015-4282-1
   Toepfer A, 2016, BMC MUSCULOSKEL DIS, V17, DOI 10.1186/s12891-016-1355-6
NR 20
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR 24
PY 2026
VL 62
IS 5
AR 809
DI 10.3390/medicina62050809
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IM0XM
UT WOS:001774915900001
PM 42195062
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Treska, V
   Certik, B
   Molacek, J
AF Treska, V
   Certik, B.
   Molacek, J.
TI Management of aortic graft infections - the present strategy and future
   perspectives
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE aortic graft infections; incidence; etiology; management; treatment
   perspectives
ID IN-SITU REPLACEMENT; VACUUM-ASSISTED CLOSURE; VASCULAR GRAFT; ARTERIAL
   RECONSTRUCTION; ENDOVASCULAR REPAIR; AORTODUODENAL FISTULA; ENDOGRAFT
   INFECTION; SILVER; EXPERIENCE; PROSTHESIS
AB Aortic graft infections (AGI) are serious complications of open and endovascular types of surgery with an incidence rate of 0.6-3 %. AGI are associated with 30-60 % perioperative mortality and 40-60 % morbidity rate with limb amputation rates between 10 % and 40 %. The economic cost of AGI is substantial. At the time of aortic reconstruction, almost 90 % of patients have one or more predisposing factors for AGI. The diagnosis is based on clinical symptomatology, laboratory markers, microbial cultures, and imaging modalities. The general principle of surgical treatment lies in the removal of infected graft, debridement of infected periprosthetic tissues, and vascular reconstruction by in situ or extra-anatomic bypass with long-term antibiotic therapy. The conservative treatment is used only for selected patients with endograft infection. This review summarizes the current knowledge about the incidence, predisposing factors, etiology, diagnosis, treatment options, and prevention of aortic vascular graft and endograft infections. With the growing number of endovascular procedures we can expect more cases of infected aortic endografts in patients with severe comorbidities in the near future, where the recent radical surgical approach (graft excision, debridement, and new revascularization) cannot be used. Therefore the less invasive, sophisticated and individualized treatment strategies will have to be used in search of the best therapeutic approach to each specific patient (Fig. 4, Ref. 82). Text in PDF www.elis.sk.
C1 [Treska, V; Certik, B.; Molacek, J.] Charles Univ Hosp, Sch Med, Dept Surg, Husova 3, CZ-32000 Plzen, Czech Republic.
C3 Charles University Prague
RP Treska, V (通讯作者)，Charles Univ Hosp, Sch Med, Dept Surg, Husova 3, CZ-32000 Plzen, Czech Republic.
EM treska@fnplzen.cz
RI /R-8655-2017; Třeška, Vladislav/L-9324-2017; , Bohuslav/R-8655-2017;
   Molacek, Jiri/R-1994-2017
OI Třeška, Vladislav/0000-0001-8066-3792; , Bohuslav/0000-0002-3724-352X;
   Molacek, Jiri/0000-0002-7445-0149
FU Charles University in Prague [P 36]
FX The article was supported by the Research Project of Charles University
   in Prague, P 36.
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NR 79
TC 21
Z9 21
U1 0
U2 8
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2016
VL 117
IS 3
BP 125
EP 132
DI 10.4149/BLL_2016_024
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DG1TX
UT WOS:000371851500001
PM 26925740
OA gold
DA 2026-07-24
ER

PT J
AU Jordan, JE
   Mays, JJ
   Shelton, JE
   Bryant, AK
   Lane, MR
   Morykwas, MJ
   Argenta, LC
AF Jordan, James E.
   Mays, Jennifer J.
   Shelton, Julie E.
   Bryant, Allyson K.
   Lane, Magan R.
   Morykwas, Michael J.
   Argenta, Louis C.
TI Mechanical Tissue Resuscitation Protects Against Myocardial
   Ischemia-Reperfusion Injury
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; BLOOD-FLOW; EDEMA;
   THERAPY
AB Background and AimReperfusion injury is a complex inflammatory response involving numerous mechanisms and pathways. Mechanical tissue resuscitation is a newly described therapeutic strategy that reduces reperfusion injury. This study further investigates potential mechanisms for the protective effects of mechanical tissue resuscitation while utilizing a bio-absorbable matrix.
   MethodsAnesthetized swine were subjected to 80minutes of coronary ischemia and three hours of reperfusion. An absorbable matrix was used to cover the ischemic-reperfused myocardium and apply the mechanical tissue resuscitation (-50mmHg) throughout reperfusion. Infarct size, myocardial blood flow (microspheres), apoptosis, edema, and hemodynamics were analyzed.
   ResultsBoth control and treated groups displayed similar hemodynamics and physiologic parameters. Mechanical tissue resuscitation significantly reduced early infarct size (16.63.8% vs. 27.3 +/- 2.5% of area at risk, p<0.05). This reduction of infarct size was accompanied by reduced edema formation in both epicardial (27% reduction) and endocardial (58% reduction) samples. Histological examination of both epicardial and endocardial tissues also revealed a reduction in apoptosis (80% and 44% reductions) in MTR-treated hearts.
   ConclusionsTreatment with mechanical tissue resuscitation during reperfusion reduces both early cell death and the delayed, programmed cell death after ischemia-reperfusion. This cardioprotection is also associated with a significant reduction in interstitial water. Additional cardioprotection may be derived from mechanical tissue resuscitation-induced increased blood flow. Mechanical tissue resuscitation, particularly with a resorbable device, is a straightforward and efficacious mechanical strategy for decreasing cardiomyocyte death following myocardial infarction as an adjunctive therapy to surgical revascularization. doi: 10.1111/jocs.12247 (J Card Surg 2014;29:116-123)
C1 [Jordan, James E.; Lane, Magan R.] Wake Forest Sch Med, Dept Cardiothorac Surg, Winston Salem, NC USA.
   [Mays, Jennifer J.; Shelton, Julie E.; Bryant, Allyson K.; Morykwas, Michael J.; Argenta, Louis C.] Wake Forest Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University
RP Argenta, LC (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM largenta@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
FU Cheek Foundation Endowment of the Department of Plastic and
   Reconstructive Surgery, Wake Forest Baptist Health; RepaiRx Laboratories
   of the Department of Plastic & Reconstructive Surgery; Department of
   Cardiothoracic Surgery, Wake Forest Baptist Health
FX Grant sponsor: Cheek Foundation Endowment of the Department of Plastic
   and Reconstructive Surgery, Wake Forest Baptist Health;Grant sponsor:
   RepaiRx Laboratories of the Department of Plastic & Reconstructive
   Surgery; Grant sponsor: Department of Cardiothoracic Surgery, Wake
   Forest Baptist Health
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NR 25
TC 5
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD JAN
PY 2014
VL 29
IS 1
BP 116
EP 123
DI 10.1111/jocs.12247
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 284HO
UT WOS:000329307000018
PM 24279831
DA 2026-07-24
ER

PT J
AU Reimer, S
   Lock, JF
   Flemming, S
   Weich, A
   Widder, A
   Plassmeier, L
   Doering, A
   Hering, I
   Hankir, MK
   Meining, A
   Germer, CT
   Groneberg, K
   Seyfried, F
AF Reimer, Stanislaus
   Lock, Johan F.
   Flemming, Sven
   Weich, Alexander
   Widder, Anna
   Plassmeier, Lars
   Doering, Anna
   Hering, Ilona
   Hankir, Mohammed K.
   Meining, Alexander
   Germer, Christoph-Thomas
   Groneberg, Kaja
   Seyfried, Florian
TI Endoscopic Management of Large Leakages After Upper Gastrointestinal
   Surgery
SO FRONTIERS IN SURGERY
LA English
DT Article
DE anastomotic leakage; endoluminal; vacuum-assisted closure; negative
   pressure; endoscopic
ID ENDOLUMINAL VACUUM THERAPY; ESOPHAGECTOMY; DEFECTS; CLOSURE
AB Background: Endoscopic vacuum therapy (EVT) is an evidence-based option to treat anastomotic leakages of the upper gastrointestinal (GI) tract, but the technical challenges and clinical outcomes of patients with large defects remain poorly described. Methods: All patients with leakages of the upper GI tract that were treated with endoscopic negative pressure therapy at our institution from 2012-2021 were analyzed. Patients with large defects (> 30 mm) as an indicator of complex treatment were compared to patients with smaller defects (control group). Results: Ninety-two patients with postoperative anastomotic or staplerline leakages were identified, of whom 20 (21.7%) had large defects. Compared to the control group, these patients required prolonged therapy (42 vs. 14 days, p < 0.001) and hospital stay (63 vs. 26 days, p < 0.001) and developed significantly more septic complications (40 vs. 17.6%, p = 0.027.) which often necessitated additional endoscopic and/or surgical/interventional treatments (45 vs. 17.4%, p = 0.007.) Nevertheless, a resolution of leakages was achieved in 80% of patients with large defects, which was similar compared to the control group (p = 0.42). Multiple leakages, especially on the opposite side, along with other local unfavorable conditions, such as foreign material mass, limited access to the defect or extensive necrosis occurred significantly more often in cases with large defects (p < 0.001). Conclusions: Overall, our study confirms that EVT for leakages even from large defects of the upper GI tract is feasible in most cases but comes with significant technical challenges.
C1 [Reimer, Stanislaus; Weich, Alexander; Meining, Alexander; Groneberg, Kaja] Univ Hosp Wurzburg, Dept Gastroenterol, Wurzburg, Germany.
   [Lock, Johan F.; Flemming, Sven; Widder, Anna; Plassmeier, Lars; Doering, Anna; Hering, Ilona; Hankir, Mohammed K.; Germer, Christoph-Thomas; Seyfried, Florian] Univ Hosp Wurzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Seyfried, F (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, Wurzburg, Germany.
EM Seyfried_F@ukw.de
RI Lock, Johan/AAA-8114-2020; Weich, Alexander/ACW-1676-2022; Flemming,
   Sven/AAA-9950-2020; Hankir, Mohammed/IZD-4807-2023
OI Lock, Johan/0000-0002-9007-3937; Meining, Alexander/0009-0001-3773-138X
CR Åkesson O, 2022, SURG ENDOSC, V36, P1903, DOI 10.1007/s00464-021-08472-4
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   Müller PC, 2021, ANN SURG, V274, P751, DOI 10.1097/SLA.0000000000005125
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   Newton NJ, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12531
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NR 16
TC 6
Z9 8
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD MAY 9
PY 2022
VL 9
AR 885244
DI 10.3389/fsurg.2022.885244
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 1T8CS
UT WOS:000804954600001
PM 35615653
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, ZX
   Li, SR
   Wang, LL
   Zhang, S
   Jiang, Y
   Chen, JP
   Luo, DL
AF Wang, Zhenxiang
   Li, Shirong
   Wang, Lingli
   Zhang, Shu
   Jiang, Yan
   Chen, Jinping
   Luo, Donglin
TI 被撤回的出版物: Polyacrylamide hydrogel injection for breast augmentation:
   Another injectable failure (Retracted Article)
SO MEDICAL SCIENCE MONITOR
LA English
DT Article; Retracted Publication
DE polyacrylamide hydrogel; augmentation mammaplasty; chronic infection
ID SOFT-TISSUE AUGMENTATION; COMPLICATIONS; MAMMAPLASTY; GEL;
   RECONSTRUCTION; DIAGNOSIS; EFFICACY; REMOVAL; SAFETY
AB Background: Increasing complications of polyaoylamide hydrogel (PAAG) augmentation mammoplasty, such as chronic persistent infection, have recently caught the attention of both the medical field and the general public.
   Material/Methods: A total of 96 patients with severe chronic infection following PAAG augmentation mammoplasty were treated in the present study including 63 cases with infection confined to the breast and 33 with systemic infection. Endoscopy and surgery were performed to completely remove the materials and clear the infected tissues followed by drug-irrigation and vacuum-assisted closure for several days.
   Results: In patients with severe infection there were large amounts of PAAG, fibers and infiltration of numerous neutrophils and macrophages. The infection-inducing materials were extensively dispersed in the mammary and subcutaneous tissues, pectoral fascia and intermuscular space. In addition, there was scattered distribution of PAAG materials in the armpit, chest wall and abdominal wall, which were mixed with necrotic tissues and surrounded by lymphocytes, giant cells, macrophages and other inflammatory cells, forming chronic granulomatous and fibrous lesions. Infection was controlled following surgical intervention. No residual infectious foci or recurrent infections were noted among these patients. Although the severe infection did not result in mastectomy, patients had breast atrophy and various degrees of deformation.
   Conclusions: Chronic infection following PAAG augmentation mammaplasty usually causes systemic infection and other devastating adverse reactions. This study confirms PAAG augmentation mammaplasty is another failed attempt. More attention should be paid to the injection of large doses of liquid filler.
C1 [Wang, Lingli; Zhang, Shu; Jiang, Yan; Chen, Jinping; Luo, Donglin] Third Mil Med Univ, Daping Hosp, Dept Breast & Thyroid Surg, Inst Surg Res, Chongqing 400042, Peoples R China.
   [Wang, Zhenxiang; Li, Shirong] Third Mil Med Univ, Southwest Hosp, Dept Plast & Aesthet Surg, Chongqing 400042, Peoples R China.
C3 Army Medical University; Army Medical University
RP Luo, DL (通讯作者)，Third Mil Med Univ, Daping Hosp, Dept Breast & Thyroid Surg, Inst Surg Res, Chongqing 400042, Peoples R China.
EM louyisjam@hotmail.com
FU National Natural Science Foundation of China [81071563]
FX Part by a grant from the National Natural Science Foundation of China
   (no. 81071563)
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NR 40
TC 24
Z9 29
U1 0
U2 21
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN
PY 2012
VL 18
IS 6
BP CR399
EP CR408
DI 10.12659/MSM.882910
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 995WG
UT WOS:000308044600017
PM 22648256
OA hybrid
DA 2026-07-24
ER

PT J
AU Gohel, MS
   Taylor, M
   Earnshaw, JJ
   Heather, BP
   Poskitt, KR
   Whyman, MR
AF Gohel, MS
   Taylor, M
   Earnshaw, JJ
   Heather, BP
   Poskitt, KR
   Whyman, MR
TI Risk factors for delayed healing and recurrence of chronic venous leg
   ulcers - An analysis of 1324 legs
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Article
DE venous ulceration; healing; recurrence; risk factor; colour venous
   duplex
ID VACUUM-ASSISTED CLOSURE; SAPHENOUS LIGATION; ULCERATION; FIBROBLASTS;
   EXPERIENCE; COMPRESSION; SENESCENCE; SURGERY; WOUNDS
AB Objective. Despite similar disease patterns and treatment, there is great variation in clinical outcome between venous ulcer patients. The aim of this study was to identify independent risk factors for venous ulcer healing and recurrence.
   Methods. Consecutive patients assessed by a specialist nurse-led leg ulcer service between January 1998 and July 2003 with an ABPI > 0.85 were included in this study. Independent risk factors for healing and recurrence were identified from routinely assessed variables using a Cox regression proportional hazards model.
   Results. A total of 1324 legs in 1186 patients were studied. The 24-week healing rate was 76% and 1 year recurrence rate was 17% (Kaplan-Meier life table analysis). Patient age (p < 0.001, HR per year 0.989, 95% Cl 0.984-0.995) and ulcer chronicity (p = 0.019, HR per month 0.996, 95% CI 0.993-0.999) were independent risk factors for delayed ulcer healing. Ulcer healing time (p < 0.001, HR per week 1.016, 95% CI 1.007-1.026) and superficial venous reflux not treated with surgery (p = 0.015, HR 2.218, 95% CI 1.166-4.218) were independent risk factors for ulcer recurrence.
   Conclusions. Elderly patients with longstanding ulcers should be targeted for further research and may benefit from adjunctive treatments to improve clinical outcomes. Patients not treated with superficial venous surgery were at increased risk of leg ulcer recurrence.
C1 Gen Hosp, Dept Vasc Surg, Cheltenham GL53 7AN, Glos, England.
C3 Gloucestershire Hospitals NHS Foundation Trust; Cheltenham General
   Hospital
RP Whyman, MR (通讯作者)，Gen Hosp, Dept Vasc Surg, Sandford Rd, Cheltenham GL53 7AN, Glos, England.
EM mark.whyman@egnhst.org.uk
CR ABUOWN A, 1994, BRIT J SURG, V81, P609
   Adhikari A, 2000, PHLEBOLOGY, V15, P2, DOI 10.1007/s005230070031
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NR 26
TC 116
Z9 135
U1 0
U2 5
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD JAN
PY 2005
VL 29
IS 1
BP 74
EP 77
DI 10.1016/j.ejvs.2004.10.002
PG 4
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 882JY
UT WOS:000225936400012
PM 15570275
OA hybrid
DA 2026-07-24
ER

PT J
AU Sharp, G
   Steffens, D
   Koh, CE
AF Sharp, Gary
   Steffens, Daniel
   Koh, Cherry E.
TI Evidence of negative pressure therapy for anastomotic leak: a systematic
   review
SO ANZ JOURNAL OF SURGERY
LA English
DT Review
DE anastomotic leak; colorectal; endosponge; negative pressure therapy
ID VACUUM-ASSISTED CLOSURE; LONG-TERM EFFICACY; ANTERIOR RESECTION;
   EXPERIENCE; ETVARD
AB Background Anastomotic leak (AL) is a devastating complication. Several new treatment options are available, endoluminal negative pressure therapy is one. The aims of this systematic review are; to report success rates and stoma closure rates following endoluminal negative pressure therapy in colorectal AL patients.
   Methods A systematic review of MEDLINE, PubMed, Cochrane and Embase databases from inception to June 2018. Search limits were; English language, humans, sample >5 and >18 years. Search terms were Endospong* OR Endo-spong* OR Endo spong* OR Endoluminal negative pressure OR Endoluninal vac* OR Vacuum assisted OR negative pressure. Combined with colon OR rectum OR colorect* AND anastomotic leak OR leak*.
   Results Twenty articles met inclusion criteria. There were 334 patients. Reported success rates ranged from 60% to 100%. However, success definition varied considerably. The most widely used definition was endoscopic assessment of residual cavity size, but this also varied from 0.5 cm to 3 cm. Stoma closure rates were only reported in 11 studies and ranged from 31% to 100%. Complication rates were reported in 13 studies (65%). The most common was on-going sepsis.
   Conclusions Included studies suggest that 60-100% of ALs heal with endoluminal negative pressure therapy. However, results from this review need to be interpreted with caution because of the variable definition of success. A more objective assessment of success may be stoma closure but this is only reported in 60% of studies. Further studies are needed to assess the benefit of negative pressure therapy in anastomotic leaks.
C1 [Sharp, Gary; Steffens, Daniel; Koh, Cherry E.] Royal Prince Alfred Hosp, Surg Outcomes Res Ctr SOuRCe, Sydney, NSW, Australia.
   [Steffens, Daniel; Koh, Cherry E.] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
   [Koh, Cherry E.] Royal Prince Alfred Hosp, Dept Colorectal Surg, Sydney, NSW, Australia.
   [Koh, Cherry E.] Royal Prince Alfred Hosp, RPA Inst Acad Surg, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; University of Sydney; NSW Health; Royal Prince
   Alfred Hospital
RP Sharp, G (通讯作者)，Royal Prince Alfred Hosp, Surg Outcomes Res Ctr SOuRCe, Missenden Rd, Camperdown, NSW 2050, Australia.
EM garybeau1@yahoo.co.uk
OI Koh, Cherry/0000-0003-2547-0204; Steffens, Daniel/0000-0002-9715-860X
CR [Anonymous], 2009, BMJ-BRIT MED J, V21, P7, DOI [DOI 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, DOI 10.7326/0003-4819-151-4-200908180-00135]
   Arezzo A, 2015, DIGEST LIVER DIS, V47, P342, DOI 10.1016/j.dld.2014.12.003
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong G, 2018, COLORECTAL DIS, V20, pO226, DOI 10.1111/codi.14257
   Aronadio E., 2017, SURG TECHNOL INT, V30, P1
   Borstlap WAA, 2018, SURG ENDOSC, V32, P315, DOI 10.1007/s00464-017-5679-6
   Boström P, 2019, BJS OPEN, V3, P106, DOI 10.1002/bjs5.50106
   Branagan G, 2005, DIS COLON RECTUM, V48, P1021, DOI 10.1007/s10350-004-0869-4
   Gardenbroek TJ, 2015, COLORECTAL DIS, V17, P426, DOI 10.1111/codi.12867
   Giaccaglia V, 2014, J CRIT CARE, V29, P528, DOI 10.1016/j.jcrc.2014.03.036
   Glitsch A, 2008, ENDOSCOPY, V40, P192, DOI 10.1055/s-2007-995384
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   Keskin M, 2015, SURG LAPARO ENDO PER, V25, P505, DOI 10.1097/SLE.0000000000000216
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NR 33
TC 14
Z9 19
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD APR
PY 2021
VL 91
IS 4
BP 537
EP 545
DI 10.1111/ans.16581
EA JAN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RM0PS
UT WOS:000609931900001
PM 33480168
DA 2026-07-24
ER

PT J
AU Hardy, EJO
   Herrod, PJ
   Doleman, B
   Phillips, HG
   Ranat, R
   Lund, JN
AF Hardy, Edward John Oliver
   Herrod, Philip J.
   Doleman, Brett
   Phillips, Hannah G.
   Ranat, Reesha
   Lund, Jonathan N.
TI Surgical interventions for the treatment of sacrococcygeal pilonidal
   sinus disease in children: A systematic review and meta-analysis
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE Pilonidal sinus; Adolescent; Child; Systematic Review; Surgery
ID VACUUM-ASSISTED CLOSURE; CLEFT LIFT PROCEDURE; LIMBERG FLAP; RHOMBOID
   EXCISION; WOUND MANAGEMENT; EARLY EXPERIENCE; OUTCOMES; SURGERY
AB Background: Pilonidal sinus disease (PNS) is not uncommon in children. Controversy remains over the best treatment and there is limited evidence. This systematic review and meta-analysis aims to establish which techniques have the best outcomes in children.
   Methods: MEDLINE, EMBASE and CENTRAL databases were searched. Studies reporting treatment outcomes for PNS in children were included.
   Results: Open healing has pooled risk of recurrence of 26% (95%Cl 15-38%), risk of wound complication of 21% (9-36%) and wound healing ranged from 38-92 days. Midline primary closure has pooled risk of recurrence of 12% (8-18%), risk of wound complication of 30% (19-46%) and wound healing ranged from 8 to 32 days. Off-midline primary closure has pooled risk of recurrence of 6% (1-15%), risk of wound complication of 14% (6-25%) and wound healing was 27 days. VAC therapy has pooled risk of recurrence of 20% (0-65%) and wound healing ranged from 38 to 92 days. Minimally invasive techniques has pooled risk of recurrence of 7% (1-16%) and wound healing ranged from 21-30 days. Marsupialisation has pooled risk of recurrence of 6% (0-22%), and wound healing ranged from 6 to 41 days.
   Conclusion: Evidence for management of PNS in children is poor. Off-midline primary closure, minimally invasive techniques, and marsupialisation have the best outcomes. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Hardy, Edward John Oliver; Herrod, Philip J.; Lund, Jonathan N.] Royal Derby Hosp, Dept Gen Surg, Derby DE22 3NE, NE, England.
   [Hardy, Edward John Oliver; Herrod, Philip J.; Doleman, Brett; Phillips, Hannah G.; Ranat, Reesha; Lund, Jonathan N.] Univ Nottingham, Dept Surg, Div Med Sci & Grad Entry Med, Derby DE22 2DT, England.
C3 University of Nottingham; University of Nottingham
RP Hardy, EJO (通讯作者)，Royal Derby Hosp, Dept Surg, Derby DE22 3NE, England.
EM edward.hardy@nhs.net
RI ; Lund, Jonathan/K-6631-2019
OI Doleman, Brett/0000-0003-4707-4755; Herrod, Philip/0000-0002-6839-3897;
   Lund, Jonathan/0000-0001-5195-2181
CR Abu Galala KH, 1999, EUR J SURG, V165, P468
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   [Anonymous], PILONIDAL SINUS FIND
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   Umesh V, 2018, J PEDIATR SURG, V53, P295, DOI 10.1016/j.jpedsurg.2017.11.036
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NR 39
TC 35
Z9 41
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD NOV
PY 2019
VL 54
IS 11
BP 2222
EP 2233
DI 10.1016/j.jpedsurg.2019.02.058
PG 12
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA JQ3LQ
UT WOS:000498851100004
PM 30940347
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lee, SS
   Lin, SD
   Chen, HM
   Lin, TM
   Yang, CC
   Lai, CS
   Chen, YF
   Chiu, CC
AF Lee, SS
   Lin, SD
   Chen, HM
   Lin, TM
   Yang, CC
   Lai, CS
   Chen, YF
   Chiu, CC
TI Management of intractable sternal wound infections with topical negative
   pressure dressing
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Plastic-Surgical-Association-Taiwan
CY DEC 21, 2002
CL Taipei, TAIWAN
SP Plast Surg Assoc Taiwan
ID VACUUM-ASSISTED CLOSURE; HEART-SURGERY; MUSCLE FLAP; MEDIASTINITIS;
   OMENTUM
AB Background: Sternal osteomyelitis after cardiac surgery is a life-threatening complication. The potential spread of infection into the mediastinum, involving the prosthetic valve, grafts, and suture lines, makes this an extremely serious complication confronting both cardiac and plastic surgeons. Aim: Topical negative pressure (TNP) dressing has been proven to be effective for wound healing. We want to take advantages of this equipment to improve the results of intractable sternal wound infection. The results are discussed. Methods: From December 1996 to July 2002, 25 patients with sternal wound infections were treated at Kaohsiung Medical University Hospital. Nine patients suffering intractable sternal osteomyelitis were managed with debridement and TNP dressings. These patients received 1-3 debridements (an average of 2.2 debridements), and the average TNP dressing treatment period was 20.2 days (ranging from 3 to 43 days). After management, the infections were controlled and healthy vascularized wounds were achieved. Then, flap reconstruction could be performed for complete wound closure. Seven of the nine patients survived, and there was no recurrence of sternal osteomyelitis during follow-up period (ranging from 5 to 70 months). Conclusion: The advantages of applying TNP dressings in cases of intractable sternal wound infections include (1) protecting the underlying mediasternal structure from infection, (2) permitting delayed sternal closure to avoid cardiac compression induced compromised cardiopulmonary function, (3) possibility of repeated wound inspection and bedside debridement, (4) cost-effectiveness of wound care, and (5) providing an option to promote sternal wound secondary healing for patients in poor physical condition.
C1 Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Plast & Reconstruct Surg, Kaohsiung 807, Taiwan.
   Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Cardiovasc Surg, Dept Surg, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital
RP Lee, SS (通讯作者)，Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Plast & Reconstruct Surg, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan.
EM sushin@kmu.edu.tw
RI Chen, Huai-Min/D-4860-2009; Chen, Ying-Fu/D-1197-2009; /D-5171-2009;
   Lai, Chung Sheng/C-7448-2009; lin, sindaw/D-5504-2009; Lee,
   Su-Shin/D-4722-2009
OI Lai, Chung Sheng/0000-0002-1298-9325; lin, sindaw/0000-0002-2269-8484; 
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NR 28
TC 7
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD MAY-JUN
PY 2005
VL 20
IS 3
BP 218
EP 222
DI 10.1111/j.1540-8191.2005.200416.x
PG 5
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Surgery
GA 930GB
UT WOS:000229402700004
PM 15854081
DA 2026-07-24
ER

PT J
AU Bachmann, J
   Feith, M
   Schlag, C
   Abdelhafez, M
   Martignoni, ME
   Friess, H
AF Bachmann, Jeannine
   Feith, Marcus
   Schlag, Christoph
   Abdelhafez, Mohamed
   Martignoni, Marc E.
   Friess, Helmut
TI Anastomotic leakage following resection of the esophagus-introduction of
   an endoscopic grading system
SO WORLD JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE Anastomotic leakage; Endoscopic grading system; Endoluminal vacuum
   therapy
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE COMPLICATIONS; SURVIVAL;
   ESOPHAGECTOMY; CANCER
AB Background Malignant tumors of the esophagus are the sixth leading cause of cancer-related deaths worldwide. Postoperative leakage of the esophago-gastrostomy leads to mediastinal sepsis, which is still associated with a high morbidity and mortality rate. The aim of this study was to describe the endoscopic view of the different severity grades of an anastomotic leakage. Methods Patients Between June 2016 and September 2018, 144 patients were operated upon in the Department of Surgery, University of Munich, Germany. Among these patients, 34 (23.6%) presented with a leakage of the anastomosis. Endoscopy In this retrospective analysis, the focus is to describe different patterns of leakage of the anastomosis. Results We studied 34 patients in whom post-esophagectomy leakage of the anastomosis was detected and treated with an endoluminal vacuum sponge system. The leakage healed in 26 of 29 patients (success rate 89.7%). With the increasing severity of leakage, the treatment time and the in-hospital mortality correspondingly increased. Furthermore, the incidence of the development of a fistula to the tracheobronchial system increased with higher grades of leakage. Conclusions Exact descriptions of leakage are necessary to compare the cases and to prove post-treatment improvement. This is, to our knowledge, the first publication to present a leakage grading score in patients after esophagectomy including reconstruction with a gastric tube. This new grading system needs to be tested in further analyses, with a special focus on prospective analysis.
C1 [Bachmann, Jeannine; Feith, Marcus; Martignoni, Marc E.; Friess, Helmut] Tech Univ Munich, Dept Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Schlag, Christoph; Abdelhafez, Mohamed] Tech Univ Munich, Dept Internal Med, Klinikum Rechts Isar, Ismaningerstr 22, D-81675 Munich, Germany.
C3 Technical University of Munich; Technical University of Munich
RP Bachmann, J (通讯作者)，Tech Univ Munich, Dept Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
EM jeannine.bachmann@tum.de
RI Schlag, Christoph/KXR-8170-2024; Abdelhafez, Mohamed/Y-6676-2019;
   Friess, Helmut/ABO-1348-2022
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 13
TC 13
Z9 13
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7819
J9 WORLD J SURG ONCOL
JI World J. Surg. Oncol.
PD MAR 31
PY 2022
VL 20
IS 1
AR 104
DI 10.1186/s12957-022-02551-z
PG 6
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA 0D5KK
UT WOS:000776033800002
PM 35354483
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mayhew, PD
   Marks, SL
   Pollard, R
   Culp, WTN
   Kass, PH
AF Mayhew, Philipp D.
   Marks, Stanley L.
   Pollard, Rachel
   Culp, William T. N.
   Kass, Philip H.
TI Prospective evaluation of surgical management of sliding hiatal hernia
   and gastroesophageal reflux in dogs
SO VETERINARY SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE THERAPY; OPEN PERITONEAL DRAINAGE; VACUUM-ASSISTED
   CLOSURE; SEPTIC PERITONITIS; OPEN ABDOMEN; GENERALIZED PERITONITIS;
   ABDOMINAL DRAINAGE; WOUND THERAPY; CATS; MORTALITY
AB Objective: To evaluate response to surgical management of sliding hiatal hernia (SHH) and gastroesophageal reflux (GER) in dogs using standardized clinical scoring, videofluoroscopic swallow studies, and impedance planimetry.
   Study design: Prospective clinical trial.
   Animals: A total of 17 client-owned dogs.
   Methods: Dogs were included if they had clinical signs and videofluoroscopic evidence of SHH and/or GER. Owners were asked to complete a standardized canine dysphagia assessment tool (CDAT) preoperatively and postoperatively. Conscious videofluoroscopic swallowing studies and impedance planimetry (IP) were used to evaluate esophageal function and lower esophageal sphincter location and geometry preoperatively and in a subsection of dogs postoperatively.
   Results: Preoperatively, 13/17 dogs included in the study had a history of regurgitation, and 4/17 had radiographic evidence of aspiration pneumonia. Postprandial regurgitation improved in 8/10 dogs with preoperative regurgitation, and for which completed preoperative and postoperative CDAT questionnaires were available (P < . 01). The hiatal hernia severity score improved postoperatively (P = .046) in dogs with preoperative and postoperative videofluoroscopic swallowing studies (n = 12). However, hernia frequency score (P = .2) and IP parameters did not differ significantly between time points.
   Conclusion: Clinical signs of SHH generally improved with surgery but did not consistently resolve. Videofluoroscopic studies provide evidence that GER and SHH can persist postoperatively in some patients. Based on IP findings, clinical improvement may be attributed to a mechanism independent of lower esophageal sphincter attenuation.
C1 [Mayhew, Philipp D.; Pollard, Rachel; Culp, William T. N.] Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, One Shields Ave, Davis, CA 95616 USA.
   [Marks, Stanley L.] Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA.
   [Kass, Philip H.] Univ Calif Davis, Populat Hlth & Reprod, Sch Vet Med, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Mayhew, PD (通讯作者)，Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, One Shields Ave, Davis, CA 95616 USA.
EM philmayhew@gmail.com
RI Kass, Philip/AFO-1125-2022
OI Culp, William/0000-0001-6132-156X
FU Center for Companion Animal Health, School of Veterinary Medicine,
   University of California-Davis
FX Supported by the Center for Companion Animal Health, School of
   Veterinary Medicine, University of California-Davis.
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NR 46
TC 20
Z9 21
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD NOV
PY 2017
VL 46
IS 8
BP 1098
EP 1109
DI 10.1111/vsu.12684
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FL4EI
UT WOS:000414180100005
PM 29090865
DA 2026-07-24
ER

PT J
AU Köhler, D
   Pohlemann, T
AF Koehler, D.
   Pohlemann, T.
TI Operative treatment of the peripelvic Morel-Lavall,e lesion
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Morel-Lavallee lesion; Pelvic ring injuries; Operative therapy; Vacuum
   therapy; Wound healing
ID VACUUM-ASSISTED CLOSURE; DEGLOVING INJURIES; WOUND CONTROL
AB Evacuation of hematoma, hemostasis, reduction of dead space by vacuum systems for minimization of secondary complications, such as full skin necrosis, deep infections, and secondary wound closure.
   Morel-Lavall,e lesion (MLL), all larger epifascial hematomas.
   None.
   Central longitudinal incision, detection of the extent of the hematoma, transection of the full length of the lesion, hemostasis, debridement, application of vacuum systems, secondary wound closure, or splitskin coverage.
   Vacuum therapy must be continued until secretions are less than 30 ml/24 hours. Negative bacterial culture before wound closure is imperative. Daily change of wound dressings, frequent control of inflammation parameters. Weight bearing until consolidation of soft tissue.
   Operative treatment of the MLL with vacuum systems is a relatively new concept, and results on larger collectives have not been published yet. A total of 8 patients in our hospital underwent vacuum therapy after sustaining a MLL, 5 of them with concomitant instability of the pelvic ring. Emergency stabilization and initiation of vacuum therapy were performed on the day of admission. Three patients had initially positive bacterial colonialization. Duration of vacuum therapy was 8.5 days (range 4-14 days). Dressings were changed every 2.6 days (range 1-4 days). While 6 wounds could be closed secondarily, 2 needed split skin coverage. Complications were not observed. Vacuum therapy facilitates wound management and helps reduce bacterial colonialization. It has also been proved to have a beneficial effect on qualitative and quantitative granulation.
C1 [Koehler, D.; Pohlemann, T.] Univ Klinikum Saarlandes, Klin Unfall Hand & Wiederherstellungschirurg, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Köhler, D (通讯作者)，Univ Klinikum Saarlandes, Klin Unfall Hand & Wiederherstellungschirurg, Kirrbergerstr 1, D-66421 Homburg, Germany.
EM daniel.koehler@uks.eu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 1997, ANN PLAST SURG, V38, P577
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NR 12
TC 7
Z9 9
U1 0
U2 6
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD FEB
PY 2011
VL 23
IS 1
BP 15
EP 20
DI 10.1007/s00064-010-0003-9
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 726WS
UT WOS:000287758100003
PM 21327954
DA 2026-07-24
ER

PT J
AU Fleck, T
   Moidl, R
   Grimm, M
   Wolner, E
   Zuckermann, A
AF Fleck, T.
   Moidl, R.
   Grimm, M.
   Wolner, E.
   Zuckermann, A.
TI Vacuum assisted closure therapy for the treatment of sternal wound
   infections after heart transplantation: Preliminary results
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE VAC therapy; heart transplantation; immunosuppression; adequate
   inflammation response
ID DELAYED CLOSURE; COMPLICATIONS; MEDIASTINITIS; BRIDGE
AB Sternal wound infection after heart transplantation is a feared and potentially life threatening complication with reported incidences between 2.5% and 3.6%. However, optimal therapy of sternal wound infections in heart transplant recipients remains a matter of controversy, particularly the effect of immunosuppression in those patients is still unclear. We examined 5 heart transplanted patients (4 men and 1 woman with a median age of 46 +/- 21.4 years (ranging from 14 to 59 years) in terms of inflammation and treatment response during VAC therapy. Infection begin was median 18.2 days (+/- 10 days, ranging from 5 to 28 days) after transplantation. VAC therapy lasted on average 12.2 +/- 2 days, ranging from 10 to 19 days. A median of 3 changes (range from 3 to 5) were necessary until the definitive closure. We examined C-reactive protein, leucocyte count and fibrinogen 2 days pre VAC, during VAC treatment and 2 days after definitive closure. All five patients showed an increase of leucocytes at every VAC change. Furthermore, we saw an adequate reaction to the VAC in terms of granulation tissue growth and resolution of infection. Transplanted patients had an increase of leucocytes at every VAC change. Furthermore all patients showed an adequate response of VAC treatment in terms of granulation tissue in growth and infection decline. Therefore a reduction of immunosuppressive therapy is not necessary, which in turn would increase the risk of rejection.
C1 Med Univ Vienna, Dept Cardiothorac Surg, Vienna, Austria.
C3 Medical University of Vienna
RP Fleck, T (通讯作者)，Univ Vienna, Chirurg Klin, Abt Herz Thoraxchirurg, AKH Vienna, Leitstelle 20A,Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM t9204604@hotmail.com
OI Zuckermann, Andreas/0000-0002-8054-8150
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
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   Hersh RE, 2001, ANN PLAS SURG, V46, P250, DOI 10.1097/00000637-200103000-00008
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NR 12
TC 4
Z9 5
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2007
VL 132
IS 2
BP 138
EP 141
DI 10.1055/s-2007-960650
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 171UO
UT WOS:000246761100009
PM 17516320
DA 2026-07-24
ER

PT J
AU Gibbs, S
   van den Hoogenband, HM
   Kirtschig, G
   Richters, CD
   Spiekstra, SW
   Breetveld, M
   Scheper, RJ
   de Boer, EM
AF Gibbs, S.
   van den Hoogenband, H. M.
   Kirtschig, G.
   Richters, C. D.
   Spiekstra, S. W.
   Breetveld, M.
   Scheper, R. J.
   de Boer, E. M.
TI Autologous full-thickness skin substitute for healing chronic wounds
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
DE autologous; inert ulcer; skin substitute; wound healing
ID DIABETIC FOOT ULCERS; VENOUS LEG ULCERS; FIBROBLASTS; KERATINOCYTES;
   FUTURE; GROWTH
AB Chronic wounds represent a major problem to our society. Therefore, advanced wound-healing strategies for the treatment of these wounds are expanding into the field of tissue engineering.
   To develop a novel tissue-engineered, autologous, full-thickness skin substitute of entirely human origin and to determine its ability to heal chronic wounds.
   Skin substitutes (fully differentiated epidermis on fibroblast-populated human dermis) were constructed from 3-mm punch biopsies isolated from patients to be treated. Acellular allodermis was used as a dermal matrix. After a prior 5-day vacuum-assisted closure therapy to prepare the wound bed, skin substitutes were applied in a simple one-step surgical procedure to 19 long-standing recalcitrant leg ulcers (14 patients; ulcer duration 0.5-50 years).
   The success rate in culturing biopsies was 97%. The skin substitute visibly resembled an autograft. Eleven of the 19 ulcers (size 1-10 cm(2)) healed within 8 weeks after a single application of the skin substitute. The other eight larger (60-150 cm(2)) and/or complicated ulcers healed completely (n = 5) or continued to decrease substantially in size (n = 3) after the 8-week follow-up period. Wound healing occurred by direct take of the skin substitute (n = 12) and/or stimulation of granulation tissue/epithelialization (n = 7). Skin substitutes were very well tolerated and pain relief was immediate after application.
   Application of this novel skin substitute provides a promising new therapy for healing chronic wounds resistant to conventional therapies.
C1 Free Univ Amsterdam, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands.
   Free Univ Amsterdam, Dept Pathol, NL-1081 HV Amsterdam, Netherlands.
   Euro Skin Bank, Beverwijk, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Gibbs, S (通讯作者)，Free Univ Amsterdam, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands.
EM s.gibbs@vumc.nl
RI spiekstra, sw/J-8957-2012; Richters, Cornelia/KIA-2309-2024
OI spiekstra, sw/0000-0002-8178-5318; 
CR Bello Y M, 2001, Am J Clin Dermatol, V2, P305, DOI 10.2165/00128071-200102050-00005
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NR 28
TC 66
Z9 80
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD AUG
PY 2006
VL 155
IS 2
BP 267
EP 274
DI 10.1111/j.1365-2133.2006.07266.x
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 063FK
UT WOS:000239003000002
PM 16882162
DA 2026-07-24
ER

PT J
AU Tanyildiz, M
   Özden,Ö
   Senköylü, K
   Eren, I
   Çakar, A
   Özbek, L
   Çakkalkurt, A
   Bilge, I
AF Tanyildiz, Murat
   Ozden, Omer
   Senkoylu, Karya
   Eren, Ilker
   Cakar, Aysu
   Ozbek, Lasin
   Cakkalkurt, Aslican
   Bilge, Ilmay
TI Should we give priority to plasma exchange and hyperbaric oxygen
   treatment before deciding on amputation for severe crush injuries?
SO TURKISH JOURNAL OF PEDIATRICS
LA English
DT Article
DE amputation; crush injury; hyperbaric oxygen treatment; therapeutic
   plasma exchange; pediatric protocol
AB Background. The most common medical sequelae after earthquakes are crush injuries and syndromes that require urgent and well-organized care, which further complicates the approach in the face of overstretched resources. The 2023 Kahramanmara & scedil;earthquake, with a magnitude of 7.7, was one of the largest disasters in T & uuml;rkiye, affecting 11 cities with a population of about 13.5 million people and claiming more than 50,000 deaths. Approximately 4.6 million pediatric patients were affected, with over 500 children undergoing amputations. The overwhelming number of cases rendered further treatment efforts nearly unfeasible. Cases. Here we present three cases of severe crush injuries in which amputation was initially considered in both primary and our tertiary centers but was prevented by a protocol that included therapeutic plasma exchange (TPE) and intensive hyperbaric oxygen treatments (HBOT). Based on our review of the literature, this appears to be the first case series documenting the use of therapeutic plasma exchange (TPE) in the management of crush injury. Conclusion. In extremities at risk for amputation, TPE therapy is crucial to preventing disseminated intravascular coagulation, systemic inflammatory response syndrome, and the accompanying multiorgan failure. It has been shown that extremities at risk for amputation due to poor perfusion can be managed confidently during the safe recovery period of daily TPE therapy with frequent HBOT, anticoagulant and vasodilator treatments, frequent wound care to prevent the development of infection, prophylactic antibiotics, vacuum-assisted closure therapy, and debridement when necessary.
C1 [Tanyildiz, Murat; Ozden, Omer; Senkoylu, Karya; Cakar, Aysu; Ozbek, Lasin] Koc Univ, Fac Med, Dept Pediat Intens Care, Istanbul, Turkiye.
   [Eren, Ilker] Koc Univ, Fac Med, Dept Orthoped & Traumatol, Istanbul, Turkiye.
   [Cakkalkurt, Aslican] Koc Univ Hosp, Dept Undersea & Hyperbar Med, Istanbul, Turkiye.
   [Bilge, Ilmay] Koc Univ, Fac Med, Dept Pediat Nephrol, Istanbul, Turkiye.
C3 Koc University; Koc University; Koc University; Koc University
RP Tanyildiz, M (通讯作者)，Koc Univ, Fac Med, Dept Pediat Intens Care, Istanbul, Turkiye.
EM murattanyildiz@gmail.com
RI ; tanyıldız, murat/IZP-6801-2023; Cakar, Aysu/KLC-5301-2024; ÖZDEN,
   ÖMER/LGZ-9822-2024; Eren, Ilker/C-7075-2018
OI ÇAKKALKURT, ASLICAN/0000-0002-9520-6225; tanyıldız,
   murat/0000-0001-8804-032X; Bilge, Ilmay/0000-0002-4852-989X; Cakar,
   Aysu/0009-0004-0510-4295; Şenköylü, Karya/0009-0009-0243-5925; ÖZDEN,
   ÖMER/0000-0003-0297-5250; Özbek, Laşin/0000-0002-2828-555X; Eren,
   Ilker/0000-0003-2965-7690
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NR 13
TC 1
Z9 1
U1 0
U2 0
PU TURKISH J PEDIATRICS
PI ANKARA
PA P K 66 SAMANPAZARI, 06240 ANKARA, Turkiye
SN 0041-4301
J9 TURKISH J PEDIATR
JI Turk. J. Pediatr.
PD JAN-FEB
PY 2025
VL 67
IS 1
BP 90
EP 100
DI 10.24953/turkjpediatr.2025.4577
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA Z5K1Y
UT WOS:001439285200010
PM 40084732
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dubée, V
   Leflon-Guibout, V
   Lenoir, T
   Fantin, B
AF Dubee, V.
   Leflon-Guibout, V.
   Lenoir, T.
   Fantin, B.
TI Wound infections after instrumented spinal surgery
SO JOURNAL DES ANTI-INFECTIEUX
LA French
DT Article
DE Surgical wound infection; Spine; Prosthesis-related infections;
   Antibiotics
ID SURGICAL-SITE INFECTION; LUMBAR INTERBODY FUSION; ERYTHROCYTE
   SEDIMENTATION-RATE; CLOSED-SUCTION IRRIGATION; VACUUM-ASSISTED CLOSURE;
   SMALL-COLONY VARIANTS; C-REACTIVE PROTEIN; RISK-FACTORS;
   STAPHYLOCOCCUS-AUREUS; POSTOPERATIVE INFECTIONS
AB Background. - Although spinal fusion surgery has become a common procedure, there are few data about surgical site infections (SSI) following instrumented spinal surgery.
   Methods. - Systematic literature review.
   Results. - 551 affect 2 to 5% of patients undergoing instrumented spinal surgery. Diabetes, obesity, malnutrition and longer operations are risk factors for 551, whereas anterior approach and cervical operations are associated with a low risk. Prognosis and clinical expression of SSI depend on the infection's extension and on the delay between surgery and first symptoms. Superficial infections should be treated with debridement surgery and a short-course of antibiotic therapy. Deep early-onset infections, occurring within 30 days after initial surgery, are most often caused by Staphylococcus aureus or Enterobacteriaceae, and are frequently associated with bacteraemia. Such infections may be treated with prompt surgical debridement with implant retention, combined with a 3-month course of antibiotics. More than 80% of patients treated along these modalities are cured of their infection. Late-onset infections are generally caused by low virulent bacteria. While most authors agree on the need for implant removal for late-onset SSI, optimal length of antibiotic therapy remains controversial.
   Conclusion. - SSI following instrumented spinal surgery present specific therapeutic challenges. Optimal management of these infections should take into account the delay between implant placement and infection's onset. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Dubee, V.; Fantin, B.] Hop Beaujon, AP HP, Serv Med Interne, F-92110 Clichy, France.
   [Leflon-Guibout, V.] Hop Beaujon, AP HP, Microbiol Serv, F-92110 Clichy, France.
   [Lenoir, T.] Hop Beaujon, AP HP, Serv Chirurg Orthoped & Rachidienne, F-92110 Clichy, France.
   [Fantin, B.] Univ Paris Diderot, F-75205 Paris 13, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Beaujon - APHP; Universite Paris Cite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Beaujon - APHP;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Beaujon - APHP; Universite Paris Cite
RP Dubée, V (通讯作者)，Hop Beaujon, AP HP, Serv Med Interne, 100 Blvd Gen Leclerc, F-92110 Clichy, France.
EM vdubee@gmail.com
RI Dubée, Vincent/F-8768-2018
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NR 88
TC 1
Z9 1
U1 0
U2 7
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-6545
J9 J ANTI-INFECT
JI J. Anti-Infect.
PD JUN
PY 2012
VL 14
IS 2
BP 68
EP 77
DI 10.1016/j.antinf.2012.04.002
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 992AC
UT WOS:000307746000003
DA 2026-07-24
ER

PT J
AU Suissa, D
   Danino, A
   Nikolis, A
AF Suissa, Daniel
   Danino, Alain
   Nikolis, Andreas
TI Negative-Pressure Therapy versus Standard Wound Care: A Meta-Analysis of
   Randomized Trials
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; MANAGEMENT; ULCERS
AB Background: Several randomized controlled trials comparing negative-pressure therapy to standard wound care for chronic wounds have been published. Although these studies suggest a benefit for negative-pressure therapy, the majority of the review articles on the topic conclude that the studies are inconclusive. The authors conducted a quantitative meta-analysis of the effectiveness of negative-pressure therapy for the management of chronic wounds.
   Methods: The MEDLINE, EMBASE, and Cochrane databases were searched from 1993 to March of 2010 for randomized controlled trials comparing negative-pressure therapy to standard wound care for chronic wounds. Measures of wound size and time to healing, along with the corresponding p values, were extracted from the randomized controlled trials. Relative change ratios of wound size and ratios of median time to healing were combined using a random effects model for meta-analysis.
   Results: Ten trials of negative-pressure therapy versus standard wound care were found. In the negative-pressure therapy group, wound size had decreased significantly more than in the standard wound care group (relative change ratio, 0.77; 95 percent confidence interval, 0.63 to 0.96). Time to healing was significantly shorter in the negative-pressure therapy group in comparison with the standard wound care group (ratio of median time to healing, 0.74; 95 percent confidence interval, 0.70 to 0.78).
   Conclusions: This quantitative meta-analysis of randomized trials suggests that negative-pressure therapy appears to be an effective treatment for chronic wounds. An effect of publication bias cannot be ruled out. (Plast. Reconstr. Surg. 128: 498e, 2011.)
C1 [Suissa, Daniel; Danino, Alain; Nikolis, Andreas] Univ Montreal, Div Plast Surg, Hop Notre Dame, Montreal, PQ, Canada.
C3 Universite de Montreal
RP Suissa, D (通讯作者)，840 Car Stewart, Montreal, PQ H4M 2X2, Canada.
EM daniel.suissa@umontreal.ca
RI Nikolis, Andreas/AAZ-4008-2020; danino, alain/E-4103-2012
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NR 30
TC 80
Z9 95
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2011
VL 128
IS 5
BP 498E
EP 503E
DI 10.1097/PRS.0b013e31822b675c
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 842GQ
UT WOS:000296583600013
PM 22030509
DA 2026-07-24
ER

PT J
AU Merrill, WH
   Akhter, SA
   Wolf, RK
   Schneeberger, EW
   Flege, JB Jr
AF Merrill, WH
   Akhter, SA
   Wolf, RK
   Schneeberger, EW
   Flege, JB Jr
TI Simplified treatment of postoperative mediastinitis
SO ANNALS OF THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 50th Annual Meeting of the Southern-Thoracic-Surgical-Association
CY NOV 13-15, 2003
CL Bonita Springs, FL
SP SoThorac Surg Assoc, Medtronic
ID VACUUM-ASSISTED CLOSURE; PRESSURE SUCTION DRAINAGE; SURGICAL-SITE
   INFECTIONS; STERNAL WOUND INFECTIONS; MEDIAN STERNOTOMY; RATIONAL
   APPROACH; DEEP; DIFFICULTIES; MANAGEMENT; SURGERY
AB Background. Wound infection after median sternotomy for cardiac or thoracic surgery is a serious complication. A variety of treatment plans have been advocated, and there is lack of agreement regarding the best treatment method. We present our results in patients with mediastinitis who have been treated in a simple, consistent manner.
   Methods. We reviewed our experience with 40 consecutive patients with mediastinitis who were treated between January 1995 and May 2003 with a single-stage treatment consisting of sternal and soft tissue debridement and wound closure over mediastinal tubes with continuous irrigation and drainage. Tubes were placed posterior to the sternum in all patients and were irrigated continuously for at least 7 days with antibiotic or antibacterial solution. Systemic antibiotics were selected based on culture and sensitivity data and were administered for 2 to 6 weeks.
   Results. All patients with mediastinitis treated in this manner survived. Of the 40 patients, 38 achieved complete healing of the wound without further operative intervention or major complication. One patient had recurrent infection and required sternal resection and advancement of muscle flaps. One patient had a residual localized focus of chondritis and underwent limited resection of cartilage.
   Conclusions. In this series of patients with postoperative mediastinitis, a simplified approach consisting of wound debridement, reclosure over drains, and anterior mediastinal irrigation has been an effective treatment. The results we have achieved suggest that this technique may be a suitable option for treating this condition.
C1 Univ Cincinnati, Dept Surg & Heart, Cincinnati, OH USA.
   Univ Cincinnati, Vasc Ctr, Sect Cardiothorac Surg, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Merrill, WH (通讯作者)，231 Albert B Sabin Way,ML 0558, Cincinnati, OH 45267 USA.
EM walter.merrill@uc.edu
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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NR 20
TC 38
Z9 45
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD AUG
PY 2004
VL 78
IS 2
BP 608
EP 612
DI 10.1016/j.athoracsur.2004.02.089
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 842JE
UT WOS:000222999300038
PM 15276531
DA 2026-07-24
ER

PT J
AU Jung, HJ
   Song, JH
   Kekatpure, AL
   Adikrishna, A
   Hong, HP
   Lee, WJ
   Chun, JM
   Jeon, IH
AF Jung, H. J.
   Song, J. H.
   Kekatpure, A. L.
   Adikrishna, A.
   Hong, H. P.
   Lee, W. J.
   Chun, J. M.
   Jeon, I. H.
TI The use of continuous negative pressure after open debridement for
   septic arthritis of the shoulder
SO BONE & JOINT JOURNAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ARTHROSCOPIC MANAGEMENT; JOINT; ADULTS
AB Aims
   The treatment of septic arthritis of the shoulder is challenging. The infection frequently recurs and the clinical outcome can be very poor. We aimed to review the outcomes following the use of continuous negative pressure after open debridement with a large diameter drain in patients with septic arthritis of the shoulder.
   Patients and Methods
   A total of 68 consecutive patients with septic arthritis of the shoulder underwent arthrotomy, irrigation and debridement. A small diameter suction drain was placed in the glenohumeral joint and a large diameter drain was placed in the subacromial space with continuous negative pressure of 15 cm H2O. All patients received a standardised protocol of antibiotics for a mean of 5.1 weeks (two to 11.1).
   Results
   Negative pressure was maintained for a mean of 24 days (14 to 32). A total of 67 patients (98.5%) were cured without further treatment being required. At a mean follow-up of 14 months (three to 72), the mean forward flexion was 123 (80 to 140) and the mean external rotation was 28 (10 to 40) in those with a rotator cuff tear, and 125 (85 to 145) and 35 (15 to 45) in those without a rotator cuff tear.
   Conclusion
   \Continuous negative pressure, following open arthrotomy, irrigation and debridement, was effective in treating septic arthritis of the shoulder. The rate of recurrence was significantly lower than with conventional treatment involving arthroscopic or open debridement reported in the literature. Functional outcomes, even in patients with rotator cuff tears, were excellent.
C1 [Jung, H. J.; Song, J. H.; Kekatpure, A. L.; Adikrishna, A.; Hong, H. P.; Lee, W. J.; Chun, J. M.; Jeon, I. H.] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthoped Surg, 86 Asanbyeongwon Gil, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Jeon, IH (通讯作者)，Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthoped Surg, 86 Asanbyeongwon Gil, Seoul 138736, South Korea.
EM jeonchoi@gmail.com
RI Kekatpure, Aashay/EWQ-7546-2022
CR Abdel MP, 2013, J SHOULDER ELB SURG, V22, P418, DOI 10.1016/j.jse.2012.05.033
   Borgquist O, 2011, PLAST RECONSTR SURG, V127, P551, DOI 10.1097/PRS.0b013e3181fed52a
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NR 15
TC 6
Z9 11
U1 0
U2 4
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD MAY
PY 2016
VL 98B
IS 5
BP 660
EP 665
DI 10.1302/0301-620X.98B5.36720
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA DL6EL
UT WOS:000375732300015
PM 27143738
DA 2026-07-24
ER

PT J
AU Floros, P
   Sawhney, R
   Vrtik, M
   Hinton-Bayre, A
   Weimers, P
   Senewiratne, S
   Mundy, J
   Shah, P
AF Floros, Peter
   Sawhney, Raja
   Vrtik, Marosh
   Hinton-Bayre, Anton
   Weimers, Paul
   Senewiratne, Shireen
   Mundy, Julie
   Shah, Pallav
TI Risk Factors and Management Approach for Deep Sternal Wound Infection
   After Cardiac Surgery at a Tertiary Medical Centre
SO HEART LUNG AND CIRCULATION
LA English
DT Article
DE Mediastinal infection; Outcomes; Risk predictors
ID VACUUM-ASSISTED CLOSURE; BYPASS GRAFT-SURGERY; LONG-TERM SURVIVAL;
   POSTSTERNOTOMY MEDIASTINITIS; THERAPY; PATHOGENESIS; IMPACT
AB Background: Deep sternal wound infection (DSWI) is a rare but severe complication following cardiac surgery. Our study investigated the risk factors and treatment options for patients who developed DSWI at our institution between May 1988 and April 2008.
   Method: Data was collected prospectively in a database and information on demographics reviewed retrospectively on 5649 patients who underwent cardiac surgery during this period.
   Results: The incidence of DSWI was 34/5649 (0.6%). These patients were older (mean age 66.1 vs. 64.5), more likely to die (in hospital mortality 11.8% vs. non DSWI group 1.8%) and had longer hospital stays (DSWI group mean stay 25 days vs. non DSWI group 9 days). Using Fisher's exact test the risk predictors for DSWI determined at our institution included diabetes managed with oral medications (p = 0.021), previous cardiac surgery (p = 0.038), BMI >= 30 (p = 0.041), LVEF <= 30 (p = 0.010), IABP usage (p = 0.028) and homologous blood usage (p < 0.001). Most commonly bilateral pectoralis major muscle flap (BPMMF) was used for treatment of DSWI (11/30, 36.7%).
   Conclusion: Ultimately our data was comparable to published data in the literature on known risk predictors. (Heart, Lung and Circulation 2011;20:712-717) Crown Copyright (C) 2011 Published by Elsevier Inc. on behalf of Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. All rights reserved.
C1 [Floros, Peter; Vrtik, Marosh; Hinton-Bayre, Anton; Weimers, Paul; Mundy, Julie; Shah, Pallav] Princess Alexandra Hosp, Dept Cardiothorac Surg, Brisbane, Qld 4102, Australia.
   [Sawhney, Raja; Senewiratne, Shireen] Princess Alexandra Hosp, Dept Plast Surg, Brisbane, Qld 4102, Australia.
C3 Princess Alexandra Hospital; Princess Alexandra Hospital
RP Shah, P (通讯作者)，Princess Alexandra Hosp, Dept Cardiothorac Surg, Brisbane, Qld 4102, Australia.
EM peter_floros@hotmail.com; pallay_shah@health.qld.gov.au
RI /B-2919-2011; /F-6551-2013
CR ARIYARATNAM P, 2010, ICVTS            AUG, P18
   Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
   De Feo M, 2001, EUR J CARDIO-THORAC, V19, P811, DOI 10.1016/S1010-7940(01)00676-5
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NR 21
TC 48
Z9 60
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1443-9506
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD NOV
PY 2011
VL 20
IS 11
BP 712
EP 717
DI 10.1016/j.hlc.2011.08.001
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 841AS
UT WOS:000296485000007
PM 21906999
DA 2026-07-24
ER

PT J
AU Messager, M
   Warlaumont, M
   Renaud, F
   Marin, H
   Branche, J
   Piessen, G
   Mariette, C
AF Messager, M.
   Warlaumont, M.
   Renaud, F.
   Marin, H.
   Branche, J.
   Piessen, G.
   Mariette, C.
TI Recent improvements in the management of esophageal anastomotic leak
   after surgery for cancer
SO EJSO
LA English
DT Review
DE Surgery; Esophagus; Stomach; Anastomotic leak; Review
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; TERM
   CLINICAL-OUTCOMES; GASTRIC TUBE; HAND-SEWN; ESOPHAGOGASTRIC ANASTOMOSIS;
   TOTAL GASTRECTOMY; CERVICAL ANASTOMOSIS; COMPUTED-TOMOGRAPHY; CONTRAST
   SWALLOW
AB Anastomotic leakage following total gastrectomy or esophagectomy is a significant complication that considerably increases postoperative mortality. The location of the anastomosis together with the anatomy of the esophagus explains the severity of this complication. Surgical knowledge should include general and specific predictive factors of leakage to avoid any technical-related cause of leakage.
   Clinical presentations may vary from minimally symptomatic to life-threatening situations. Investigations should be undertaken as soon as the diagnosis is suspected because delay greatly worsens the prognosis. CT scans with oral contrast and low insufflation early endoscopy are the preferred diagnostic tools and can also aid in therapeutic procedures.
   Communication and multidisciplinary teamwork are the cornerstones of treatment. When the leak occurs early with acute and important sepsis, the recommendation is surgical treatment. On the contrary, if the leak is late, non-symptomatic or minimally symptomatic, conservative management with intensive surveillance could be proposed. When the situation is in between these two extremes, endoscopic treatment is often proposed.
   Based on a review of the literature and experience from high volume centers, in this educational review, we present the incidence, predictive factors, clinical presentations, diagnostic tools, management, and therapeutic algorithms for anastomotic leaks following elective esophagectomy and total gastrectomy for cancer. (C) 2016 Elsevier Ltd, BASO - the Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
C1 [Messager, M.; Warlaumont, M.; Marin, H.; Piessen, G.; Mariette, C.] Univ Lille, Claude Huriez Univ Hosp, Dept Digest & Oncol Surg, F-59000 Lille, France.
   [Messager, M.; Warlaumont, M.; Renaud, F.; Piessen, G.; Mariette, C.] Univ Lille, JPARC, Ctr Rech Jean Pierre AUBERT Neurosci & Canc, UMR S 1172, F-59000 Lille, France.
   [Messager, M.; Renaud, F.; Piessen, G.; Mariette, C.] INSERM, UMR S 1172, F-59000 Lille, France.
   [Mariette, C.] SIRIC ONCOLille, Lille, France.
   [Renaud, F.] Univ Lille, Univ Hosp, Ctr Biol & Pathol, Dept Pathol, F-59000 Lille, France.
   [Branche, J.] Univ Lille, Claude Huriez Univ Hosp, Dept Gastroenterol, F-59000 Lille, France.
C3 Universite de Lille; CHU Lille; Universite de Lille; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Lille;
   Universite de Lille; CHU Lille; Universite de Lille; CHU Lille
RP Mariette, C (通讯作者)，Univ Hosp Claude Huriez, Dept Digest Surg, Lille, France.
EM christophe.mariette@chru-lille.fr
RI RENAUD, Florence/V-5064-2019; piessen, guillaume/O-4241-2017
OI RENAUD, Florence/0000-0003-3614-1713; 
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NR 111
TC 137
Z9 162
U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0748-7983
EI 1532-2157
J9 EJSO-EUR J SURG ONC
JI EJSO
PD FEB
PY 2017
VL 43
IS 2
BP 258
EP 269
DI 10.1016/j.ejso.2016.06.394
PG 12
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA EK6YN
UT WOS:000394072300005
PM 27396305
DA 2026-07-24
ER

PT J
AU Dubert, M
   Pourbaix, A
   Alkhoder, S
   Mabileau, G
   Lescure, FX
   Ghodhbane, W
   Belorgey, S
   Rioux, C
   Armand-Lefèvre, L
   Wolff, M
   Raffoul, R
   Nataf, P
   Yazdanpanah, Y
   Lucet, JC
AF Dubert, Marie
   Pourbaix, Annabelle
   Alkhoder, Soleiman
   Mabileau, Guillaume
   Lescure, Francois-Xavier
   Ghodhbane, Walid
   Belorgey, Sabine
   Rioux, Christophe
   Armand-Lefevre, Laurence
   Wolff, Michel
   Raffoul, Richard
   Nataf, Patrick
   Yazdanpanah, Yazdan
   Lucet, Jean-Christophe
TI Sternal Wound Infection after Cardiac Surgery: Management and Outcome
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; REDON CATHETERS;
   RISK-FACTORS; DRAINS
AB Background
   Sternal Wound Infection (SWI) is a severe complication after cardiac surgery. Debridement associated with primary closure using Redon drains (RD) is an effective treatment, but data on RD management and antibiotic treatment are scarce.
   Methods
   We performed a single-center analysis of consecutive patients who were re-operated for SWI between 01/2009 and 12/2012. All patients underwent a closed drainage with RD (CDRD). Patients with endocarditis or those who died within the first 45 days were excluded from management analysis. RD fluid was cultured twice weekly. Variables recorded were clinical and biological data at SWI diagnosis, severity of SWI based on criteria for mediastinitis as defined by the Centers for Disease Control (CDC), antibiotic therapy, RD management and patient's outcome.
   Results
   160 patients developed SWI, 102 (64%) fulfilled CDC criteria (CDC+) and 58 (36%) did not (CDC-SWI). Initial antibiotic treatment and surgical management were similar in CDC+ and CDC-SWI. Patients with CDC+ SWI had a longer duration of antibiotic therapy and a mortality rate of 17% as compared to 3% in patients with CDC-SWI (p = 0.025). Rates of superinfection (10% and 9%) and need for second reoperation (12% and 17%) were similar. Failure (death or need for another reoperation) was associated with female gender, higher EuroScore for prediction of operative mortality, and stay in the ICU.
   Conclusion
   In patients with SWI, initial one-stage surgical debridement with CDRD is associated with favorable outcomes. CDC+ and CDC- SWI received essentially the same management, but CDC+ SWI has a more severe outcome.
C1 [Dubert, Marie; Pourbaix, Annabelle; Lescure, Francois-Xavier; Rioux, Christophe; Yazdanpanah, Yazdan] Bichat Claude Bernard Hosp, AP HP, Dept Infect Dis, Paris, France.
   [Alkhoder, Soleiman; Ghodhbane, Walid; Raffoul, Richard; Nataf, Patrick] Bichat Claude Bernard Hosp, AP HP, Dept Cardiac Surg, Paris, France.
   [Mabileau, Guillaume; Lescure, Francois-Xavier; Wolff, Michel; Yazdanpanah, Yazdan; Lucet, Jean-Christophe] Univ Paris 07, INSERM, IAME, UMR 1137, F-75018 Paris, France.
   [Mabileau, Guillaume; Lescure, Francois-Xavier; Wolff, Michel; Yazdanpanah, Yazdan; Lucet, Jean-Christophe] Univ Paris Diderot, Sorbonne Paris Cite, F-75018 Paris, France.
   [Belorgey, Sabine; Lucet, Jean-Christophe] Bichat Claude Bernard Hosp, AP HP, Infect Control Unit, Paris, France.
   [Armand-Lefevre, Laurence] Bichat Claude Bernard Hosp, AP HP, Bacteriol Lab, Paris, France.
   [Wolff, Michel] Bichat Claude Bernard Hosp, AP HP, Med Intens Care Unit, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Bichat-Claude Bernard - APHP; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Bichat-Claude Bernard - APHP; Universite Paris Cite; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Bichat-Claude Bernard - APHP; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Bichat-Claude Bernard - APHP; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Bichat-Claude Bernard -
   APHP
RP Lucet, JC (通讯作者)，Univ Paris 07, INSERM, IAME, UMR 1137, F-75018 Paris, France.
EM jean-christophe.lucet@bch.aphp.fr
RI ; ARMAND-LEFEVRE, Laurence/A-4751-2018; Lescure, Xavier/AAM-5261-2020
OI Mabileau, Guillaume/0000-0003-1691-7625; ARMAND-LEFEVRE,
   Laurence/0000-0002-2013-3252; Nataf, Patrick/0000-0002-8412-6182
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NR 23
TC 21
Z9 25
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 30
PY 2015
VL 10
IS 9
AR e0139122
DI 10.1371/journal.pone.0139122
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CS6GF
UT WOS:000362175700070
PM 26422144
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Corradino, B
   Di Lorenzo, S
   Hubova, M
   Cordova, A
AF Corradino, Bartolo
   Di Lorenzo, Sara
   Hubova, Martina
   Cordova, Adriana
TI Propeller flap for treatment of a poststernotomy sternal fistula: A case
   report
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Sternal fistula; Propeller flap; Sternal wound infection; Sternotomy;
   Propeller freestyle flap
ID EMORY 20-YEAR EXPERIENCE; MEDIAN STERNOTOMY; CARDIAC-SURGERY; MUSCLE
   FLAPS; MANAGEMENT; RECONSTRUCTION; OSTEOMYELITIS
AB The treatment of post-operative deep sternal wound infections is a real challenge for surgeons. Conservative treatment with debridement and vacuum-assisted closure (VAC) therapy is not always successful. In the most severe and chronic cases, a surgical debridement and reconstruction of the defect is mandatory.
   In this report, the authors present a case of a 61-year-old female patient with a chronic cutaneous fistula in the sternal region following a median sternotomy after coronary artery bypass. The patient had already undergone treatment with antibiotics, drainage of an abscess and local debridement, but the infection continued to relapse periodically. The authors decided to treat the fistula with debridement and reconstruction with a local freestyle propeller flap mobilised from the right parasternal region.
   Results: The fistula healed without any complications. There has been no relapse, and the aesthetic result is satisfactory. The scar at the donor site is acceptable with a minimum alteration to the mammary region.
   Conclusions: Sternal fistulas after medial sternotomy are difficult to treat. The treatment method of debridement followed, in certain cases, by VAC therapy is quite controversial. A surgical procedure is sometimes necessary to speed healing. Mobilisation of a freestyle propeller flap represents a less invasive surgical approach to the treatment of sternal fistulas in cases of conservative treatment failure. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Corradino, Bartolo; Di Lorenzo, Sara; Hubova, Martina; Cordova, Adriana] Univ Palermo, Dipartimento Discipline Chirurg Oncol & Stomatol, I-90127 Palermo, Italy.
C3 University of Palermo
RP Hubova, M (通讯作者)，Univ Palermo, Dipartimento Discipline Chirurg Oncol & Stomatol, Via Vespro 129, I-90127 Palermo, Italy.
EM hubova.m@gmail.com
OI Cordova, Aiana/0000-0002-5137-4294; CORRADINO,
   Bartolo/0000-0003-1830-0530; di lorenzo, sara/0000-0003-1688-1159; Di
   Lorenzo, Sara/0009-0007-0218-6258
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NR 9
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2014
VL 67
IS 11
BP E266
EP E269
DI 10.1016/j.bjps.2014.07.033
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AU3PY
UT WOS:000345527100002
PM 25213714
DA 2026-07-24
ER

PT J
AU Baker, RM
   Brasch, ME
   Manning, ML
   Henderson, JH
AF Baker, Richard M.
   Brasch, Megan E.
   Manning, M. Lisa
   Henderson, James H.
TI Automated, contour-based tracking and analysis of cell behaviour over
   long time scales in environments of varying complexity and cell density
SO JOURNAL OF THE ROYAL SOCIETY INTERFACE
LA English
DT Article
DE automated cell tracking; shape-memory polymers; mechanobiology; contour
   method; collective behaviour
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; EXTRACELLULAR-MATRIX;
   DURA-MATER; SHAPE; MIGRATION; STRAIN; TISSUE; MORPHOGENESIS; FEATURES
AB Understanding single andcollective cellmotility inmodel environments is foundational to many current research efforts in biology and bioengineering. To elucidate subtle differences in cell behaviour despite cell-to-cell variability, we introduce an algorithm for tracking large numbers of cells for long time periods and present a set of physics-basedmetrics that quantify differences in cell trajectories. Our algorithm, termed automated contour-based tracking for in vitro environments (ACTIVE), was designed for adherent cell populations subject to nuclear staining or transfection. ACTIVE is distinct from existing tracking software because it accommodates both variability in image intensity and multi-cell interactions, such as divisions and occlusions. When applied to low-contrast images from live-cell experiments, ACTIVE reduced error in analysing cell occlusion events by as much as 43% compared with a benchmark-tracking program while simultaneously tracking cell divisions and resulting daughter-daughter cell relationships. The large dataset generated by ACTIVE allowed us to develop metrics that capture subtle differences between cell trajectories on different substrates. We present cell motility data for thousands of cells studied at varying densities on shape-memory-polymer-based nanotopographies and identify several quantitative differences, including an unanticipated difference between two 'control' substrates. We expect that ACTIVE will be immediately useful to researchers who require accurate, long-time-scale motility data for many cells.
C1 [Baker, Richard M.; Brasch, Megan E.; Henderson, James H.] Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA.
   [Baker, Richard M.; Brasch, Megan E.; Manning, M. Lisa; Henderson, James H.] Syracuse Univ, Syracuse Biomat Inst, Syracuse, NY 13244 USA.
   [Manning, M. Lisa] Syracuse Univ, Dept Phys, Syracuse, NY 13244 USA.
C3 Syracuse University; Syracuse University; Syracuse University
RP Henderson, JH (通讯作者)，Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY 13244 USA.
EM jhhender@syr.edu
RI Henderson, James/K-6187-2012; Manning, M. Lisa/B-1746-2012
OI Henderson, James/0000-0003-3355-5953; Manning, M.
   Lisa/0000-0001-7682-2324
FU National Science Foundation under an IGERT Fellowship [DGE-1068780];
   DARPA under Young Faculty Award [D12AP00271];  [CMMI-1334611]; Direct
   For Mathematical & Physical Scien; Division Of Materials Research
   [1352184] Funding Source: National Science Foundation; Directorate For
   Engineering; Div Of Civil, Mechanical, & Manufact Inn [1334611] Funding
   Source: National Science Foundation
FX This material is based upon work supported by the National Science
   Foundation under an IGERT Fellowship (DGE-1068780) to M. E. B. and
   Forrest Smith and under an award (CMMI-1334611) to J.H.H. and M. L. M.,
   and by DARPA under a Young Faculty Award (D12AP00271) to J.H.H.
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NR 70
TC 25
Z9 39
U1 0
U2 41
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1742-5689
EI 1742-5662
J9 J R SOC INTERFACE
JI J. R. Soc. Interface
PD AUG 6
PY 2014
VL 11
IS 97
AR 20140386
DI 10.1098/rsif.2014.0386
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AK5AM
UT WOS:000338436200019
PM 24920119
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Ubbink, DT
   Westerbos, SJ
   Nelson, EA
   Vermeulen, H
AF Ubbink, D. T.
   Westerbos, S. J.
   Nelson, E. A.
   Vermeulen, H.
TI A systematic review of topical negative pressure therapy for acute and
   chronic wounds
SO BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; RANDOMIZED-TRIAL;
   MANAGEMENT; ULCERS
AB Topical negative pressure (TNP) therapy is becoming increasingly popular for all kinds of wounds. Its clinical and cost effectiveness is unclear.
   A search of randomized controlled trials (RCTs) on TNP in adult patients with all kinds of wounds in all settings was undertaken in Medline, Embase, Cinahl (to October 2007) and the Cochrane Library (to issue 4,2007). Information was also sought from manufacturer of the VAC (R) device. Selection of trials for analysis, quality assessment, data abstraction and data synthesis were conducted by two authors independently. The primary endpoint was any measure of wound healing. Secondary endpoints were infection, pain, quality of life, oedema, microcirculation, bacterial load, adverse events, duration of hospital stay and cost.
   The search identified 15 publications on 13 RCTs. These reported on patients with chronic wounds, diabetic wounds, pressure ulcers, skin grafts and acute wounds. In chronic and diabetic wounds, TNP did not allow earlier complete wound healing. It was, however, associated with a 1-10 day reduction in the time needed to prepare the wound for secondary closure surgery. In one trial on acute wounds, 17 (95 per cent confidence interval (c.i.) 0.02 to 0.32) per cent more wounds appeared to heal with TNP; the number needed to treat was six. This was, however, at the cost of an It (95 per cent c.i. 0.01 to 0.21) per cent higher complication rate; the number needed to harm was nine.
   There is little evidence to support the use of TNP in the treatment of wounds.
C1 [Ubbink, D. T.] Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, NL-1100 DE Amsterdam, Netherlands.
   [Ubbink, D. T.] Univ Amsterdam, Acad Med Ctr, Dept Surg, NL-1100 DE Amsterdam, Netherlands.
   [Westerbos, S. J.] Univ Amsterdam, Dept Clin Epidemiol Biostat & Bioinformat, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands.
   [Nelson, E. A.] Univ Leeds, Sch Healthcare, Leeds, W Yorkshire, England.
   [Vermeulen, H.] Univ Amsterdam, Amsterdam Sch Nursing, NL-1100 DE Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam; University of Leeds;
   University of Amsterdam
RP Ubbink, DT (通讯作者)，Univ Amsterdam, Acad Med Ctr, Dept Qual Assurance & Proc Innovat, Meibergdreef 9,Room J1B-215,POB 22700, NL-1100 DE Amsterdam, Netherlands.
EM D.Ubbink@amc.nl
RI Vermeulen, Hester/P-5739-2016; Ubbink, Dirk/AAF-1266-2021; Nelson,
   Andrea/K-2733-2012
OI Vermeulen, Hester/0000-0002-0743-2979; Ubbink, Dirk/0000-0001-9398-8879;
   Nelson, Andrea/0000-0001-6741-3078
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NR 30
TC 174
Z9 200
U1 0
U2 34
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JUN
PY 2008
VL 95
IS 6
BP 685
EP 692
DI 10.1002/bjs.6238
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 336VA
UT WOS:000258391500004
PM 18446777
OA Bronze
DA 2026-07-24
ER

PT J
AU Mills, C
   Bryson, P
AF Mills, Christian
   Bryson, Philip
TI The role of hyperbaric oxygen therapy in the treatment of sternal wound
   infection
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Review
DE surgical wound infection; hyperbaric oxygenation; coronary artery bypass
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY ULCERS; MEDIAN STERNOTOMY;
   RISK-FACTORS; POSTOPERATIVE MEDIASTINITIS; INSPIRED OXYGEN;
   CARDIAC-SURGERY; BLOOD-FLOW; ARTERY; DEEP
AB Sternal wound dehiscence and infection are major problems for patients and health care providers. A range of risk factors, including diabetes, obesity and internal thoracic artery harvest, has been implicated. Several pathophysiological mechanisms, which may account for the development of infection, have been proposed. There is a growing body of evidence which suggests that sternal ischaemia may play a significant role in the initiation of wound infection, and that this may be exacerbated by harvest of the internal thoracic artery. Current treatments for infection include wound debridement, irrigation and tissue flap reconstruction. In addition, several novel therapies such as negative pressure dressings have been shown to be safe and useful. Hyperbaric oxygen therapy - the administration of 100% oxygen at pressures greater than atmospheric pressure - is widely used in the treatment of various chronic wounds. The mechanism whereby hyperbaric oxygen exerts its effects is being elucidated and there is a growing body of clinical evidence that supports its use. It has been suggested that there may be a role for hyperbaric oxygen therapy in the treatment of sternal infection. The theoretical mechanisms would seem plausible, but at present there is only limited evidence to support its use. This review addresses the theory and evidence supporting the role of hyperbaric oxygen therapy in the treatment of sternal wound infection. (c) 2006 Elsevier B.V. All rights reserved.
C1 Hyperbar Med Ctr, Diving Dis Res Ctr, Plymouth, Devon, England.
RP Mills, C (通讯作者)，Hyperbar Med Ctr, Diving Dis Res Ctr, Res Way, Plymouth, Devon, England.
EM chris.mills@ddrc.org
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NR 64
TC 21
Z9 26
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUL
PY 2006
VL 30
IS 1
BP 153
EP 159
DI 10.1016/j.ejcts.2006.03.059
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 062GP
UT WOS:000238932900034
PM 16769519
OA Bronze
DA 2026-07-24
ER

PT J
AU Kanamori, J
   Okada, N
   Fujiwara, H
   Mayanagi, S
   Fujita, T
   Nagino, M
   Daiko, H
AF Kanamori, J.
   Okada, N.
   Fujiwara, H.
   Mayanagi, S.
   Fujita, T.
   Nagino, M.
   Daiko, H.
TI Leak grading and percutaneous transanastomotic drainage for the
   treatment of cervical anastomotic leakage after esophagectomy
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leakage; esophagectomy; treatment
ID VACUUM-ASSISTED CLOSURE; TUBE DRAINAGE; MANAGEMENT; COMPLICATIONS;
   CANCER; DATABASE; FISTULA; SURGERY; RISK
AB Anastomotic leakage, a major complication of esophagectomy, can be fatal. However, there is no consensus on treatment strategy for this critical complication. Percutaneous trans-anastomotic drainage (PTD) refers to intraluminal trans-fistula vacuum drainage for cervical anastomotic leakage. This study aims to evaluate the efficacy of this form of treatment according to leak grade. The severity of leakage in the 117 of 647 consecutive postesophagectomy patients with cervical anastomosis leaks was graded according to esophagogram findings as follows: Grade I, linear extravasation; Grade II, localized obvious cavity; and Grade III, large cavity extending into the mediastinum or thoracic cavity. Treatment tended to be allocated according to grading, PTD being performed in most patients with Grades II and III. Three cases with conduit necrosis requiring immediate surgical intervention were excluded. Leakage was detected by radiologic evaluation in 117 (18.2%) of the remaining 644 patients, over half being Grade II (51%). Patients with Grade II leaks who underwent PTD required significantly shorter treatment (PTD: 16.8 days/non-PTD: 22.3 days; P= 0.02). Moreover, patients who underwent PTD within 3 days of diagnosis (n= 29) required significantly shorter treatment than those who underwent it 4+ days after diagnosis (n= 14) (earlyPTD: 14.9 days/late-PTD: 20.6 days; P = 0.01). It is useful to assign treatment strategy according to leak grading. Additionally, PTD promotes early healing and is considered a valuable treatment option for cervical anastomotic leakage.
C1 [Kanamori, J.; Okada, N.; Fujiwara, H.; Mayanagi, S.; Fujita, T.; Daiko, H.] Natl Canc Ctr Hosp East, Dept Esophageal Surg, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan.
   [Kanamori, J.; Nagino, M.] Nagoya Univ, Grad Sch Med, Dept Surg, Div Surg Oncol,Showa Ku, Nagoya, Aichi, Japan.
C3 National Cancer Center - Japan; Nagoya University
RP Daiko, H (通讯作者)，Natl Canc Ctr Hosp East, Dept Esophageal Surg, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan.
EM hdaikou@east.ncc.go.jp
RI Nagino, Masato/I-7342-2014; 岡田, 尚也/K-9535-2019
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NR 20
TC 3
Z9 4
U1 0
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAY
PY 2017
VL 30
IS 5
DI 10.1093/dote/dow029
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FA5SW
UT WOS:000405505000019
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Saggini, R
   Figus, A
   Troccola, A
   Cocco, V
   Saggini, A
   Scuderi, N
AF Saggini, R.
   Figus, A.
   Troccola, A.
   Cocco, V.
   Saggini, A.
   Scuderi, N.
TI Extracorporeal shock wave therapy for management of chronic ulcers in
   the lower extremities
SO ULTRASOUND IN MEDICINE AND BIOLOGY
LA English
DT Article
DE extracorporeal shock waves therapy; shock waves; chronic ulcers; chronic
   wounds; difficult wounds; lower extremities ulcers
ID WOUND BED PREPARATION; REDUCE ISCHEMIC NECROSIS; VACUUM-ASSISTED
   CLOSURE; SKIN FLAP MODEL; GROWTH-FACTOR; GENE-THERAPY; ULTRASOUND;
   STIMULATION; PAIN; LITHOTRIPSY
AB Management of chronic ulcers in the lower extremities is still a challenge for patients and health providers. Recent studies showed extracorporeal shock waves (ESW) as effective in stimulating growth factors, inducing angiogenesis and healing of fractures and injuries. This study was planned to investigate the opportunity of introducing the ESW in the treatment of chronic wounds. Thirty consecutive patients with chronic posttraumatic, venous and diabetic ulcers, unresponsive to conservative or advanced dressing treatments, were counseled about the use of ESW as alternative treatment for their wounds. Thirty-two wounds were treated and 16 wounds healed completely within six sessions of ESW. In all of the nonhealed wounds, decrease of the amount of exudates, increased percentage of granulation tissue compared with fibrin/necrotic tissue and decrease of wounds' size were statistically significant after four to six sessions of ESW (p < 0.01). Significant decrease of pain was reported (p < 0.001). Comparison with a control group of 10 patients with chronic ulcer treated on the basis of regular dressings confirmed the statistical significant improvement in the healing process (p < 0.01). ESW therapy seems to be a safe, feasible and cost-effective treatment for chronic ulcers in the lower extremities. Further research and clinical trials are necessary to evaluate dose and time intervals of sessions to standardize a protocol of treatment in the management of chronic wounds.
C1 [Saggini, R.; Cocco, V.; Saggini, A.] Univ G dAnnunzio, Dept Phys Med & Rehabil, Chieti, Italy.
   [Figus, A.; Troccola, A.; Scuderi, N.] Univ Rome Sapienza, Dept Plast & Reconstruct Surg, Rome, Italy.
C3 G d'Annunzio University of Chieti-Pescara; Sapienza University Rome
RP Scuderi, N (通讯作者)，Univ Rome Sapienza, Dept Plast Surg, Vle Policlin, Rome, Italy.
EM nicolo.scuderi@uniromal.it
RI /J-2711-2018; Figus, Anea/AAC-2515-2022
OI Figus, Anea/0000-0001-7889-7856
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NR 60
TC 97
Z9 113
U1 1
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0301-5629
EI 1879-291X
J9 ULTRASOUND MED BIOL
JI Ultrasound Med. Biol.
PD AUG
PY 2008
VL 34
IS 8
BP 1261
EP 1271
DI 10.1016/j.ultrasmedbio.2008.01.010
PG 11
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 334SM
UT WOS:000258241500009
PM 18394777
DA 2026-07-24
ER

PT J
AU Cereatti, F
   Grassia, R
   Drago, A
   Conti, CB
   Donatelli, G
AF Cereatti, Fabrizio
   Grassia, Roberto
   Drago, Andrea
   Conti, Clara Benedetta
   Donatelli, Gianfranco
TI Endoscopic management of gastrointestinal leaks and fistulae: What
   option do we have?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Leak; Fistula; Endotherapy; Over-the-scope clip; Suturing system;
   Endo-vacuum therapy; Endoscopic internal drainage; Self-expandable metal
   stent
ID ESOPHAGEAL ANASTOMOTIC LEAKS; VACUUM-ASSISTED CLOSURE; EXPANDABLE METAL
   STENT; SLEEVE GASTRECTOMY; INTERNAL DRAINAGE; MULTICENTER EXPERIENCE;
   CLINICAL-OUTCOMES; GASTRIC BYPASS; PLASTIC STENTS; THERAPY
AB Gastrointestinal leaks and fistulae are serious, potentially life threatening conditions that may occur with a wide variety of clinical presentations. Leaks are mostly related to post-operative anastomotic defects and are responsible for an important share of surgical morbidity and mortality. Chronic leaks and long standing post-operative collections may evolve in a fistula between two epithelialized structures. Endoscopy has earned a pivotal role in the management of gastrointestinal defects both as first line and as rescue treatment. Endotherapy is a minimally invasive, effective approach with lower morbidity and mortality compared to revisional surgery. Clips and luminal stents are the pioneer of gastrointestinal (GI) defect endotherapy, whereas innovative endoscopic closure devices and techniques, such as endoscopic internal drainage, suturing system and vacuum therapy, has broadened the indications of endoscopy for the management of GI wall defect. Although several endoscopic options are currently used, a standardized evidence-based algorithm for management of GI defect is not available. Successful management of gastrointestinal leaks and fistulae requires a tailored and multidisciplinary approach based on clinical presentation, defect features (size, location and onset time), local expertise and the availability of devices. In this review, we analyze different endoscopic approaches, which we selected on the basis of the available literature and our own experience. Then, we evaluate the overall efficacy and procedural-specific strengths and weaknesses of each approach.
C1 [Cereatti, Fabrizio; Grassia, Roberto; Drago, Andrea; Conti, Clara Benedetta] Cremona Hosp, Digest Endoscopy & Gastroenterol Unit, Viale Concordia 1, I-26100 Cremona, Italy.
   [Donatelli, Gianfranco] Hosp Prive Peupliers, Dept Intervent Endoscopy, Ramsay Sante, F-75013 Paris, France.
RP Cereatti, F (通讯作者)，Cremona Hosp, Digest Endoscopy & Gastroenterol Unit, Viale Concordia 1, I-26100 Cremona, Italy.
EM cereatti.fabrizio@gmail.com
OI Donatelli, Gianfranco/0000-0003-0645-1710; Conti, Clara
   Benedetta/0000-0001-9774-2374
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NR 108
TC 57
Z9 80
U1 1
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD AUG 7
PY 2020
VL 26
IS 29
DI 10.3748/wjg.v26.i29.4198
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NE7OA
UT WOS:000562790400002
PM 32848329
OA Green Accepted, hybrid
DA 2026-07-24
ER

PT J
AU Serra, R
   Rizzuto, A
   Rossi, A
   Perri, P
   Barbetta, A
   Abdalla, K
   Caroleo, S
   Longo, C
   Amantea, B
   Sammarco, G
   de Franciscis, S
AF Serra, Raffaele
   Rizzuto, Antonia
   Rossi, Alessio
   Perri, Paolo
   Barbetta, Andrea
   Abdalla, Karim
   Caroleo, Santo
   Longo, Chiara
   Amantea, Bruno
   Sammarco, Giuseppe
   de Franciscis, Stefano
TI Skin grafting for the treatment of chronic leg ulcers - a systematic
   review in evidence-based medicine
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Arterial ulcer; Chronic leg ulcer; Diabetic ulcer; Skin graft; Venous
   ulcer
ID VACUUM-ASSISTED CLOSURE; RHEUMATOID-ARTHRITIS; ULCERATION; VASCULITIS;
   REMOVAL; SALVAGE; DEVICE
AB Skin grafting is one of the most common surgical procedures in the area of non-healing wounds by which skin or a skin substitute is placed over a wound to replace and regenerate the damaged skin. Chronic leg ulcers are an important problem and a major source of expense for Western countries and for which many different forms of treatment have been used. Skin grafting is a method of treatment that decreases the area of chronic leg ulcers or heals them completely, thus improving a patient's quality of life. Skin grafting is an old technique, rediscovered during the first and second world wars as the main treatment for wound closure. Nowadays, skin grafting has a pivotal role in the context of modern wound healing and tissue regeneration. The aim of this review was to track and to analyse the specific outcomes this technique achieved, especially in the last decade, in relation to venous, arterial, diabetic, rheumatoid and traumatic leg ulcers. Our main findings indicate that autologous split-thickness skin grafting still remains the gold standard in terms of safety and efficacy for chronic leg ulcers; skin grafting procedures have greater success rates in chronic venous leg ulcers compared to other types of chronic leg ulcers; skin tissue engineering, also supported by genetic manipulation, is quickly expanding and, in the near future, may provide even better outcomes in the area of treatments for long-lasting chronic wounds.
C1 [Serra, Raffaele; de Franciscis, Stefano] Magna Graecia Univ Catanzaro, Int Res & Educ Program Clin & Expt Biotechnol, Interuniv Ctr Phlebolymphol CIFL, Catanzaro, Italy.
   [Serra, Raffaele; Rizzuto, Antonia; Perri, Paolo; Barbetta, Andrea; Abdalla, Karim; Caroleo, Santo; Amantea, Bruno; Sammarco, Giuseppe; de Franciscis, Stefano] Univ Catanzaro, Dept Med & Surg Sci, Viale Europa, I-88100 Catanzaro, Italy.
   [Rossi, Alessio] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Campobasso, Italy.
   [Longo, Chiara] Hosp St Flour, Dept Phys Med & Rehabil, St Flour, France.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; University of Molise
RP Serra, R (通讯作者)，Univ Catanzaro, Dept Med & Surg Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM rserra@unicz.it
RI Sammarco, Giuseppe/ABG-8058-2020; Serra, Raffaele/AAA-6874-2022;
   Rizzuto, Antonia/GVT-4842-2022
OI Serra, Raffaele/0000-0003-4477-7412; Rizzuto,
   Antonia/0000-0003-4359-4702
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NR 64
TC 63
Z9 75
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 149
EP 157
DI 10.1111/iwj.12575
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100022
PM 26940940
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kafka-Ritsch, R
   Birkfellner, F
   Perathoner, A
   Raab, H
   Nehoda, H
   Pratschke, J
   Zitt, M
AF Kafka-Ritsch, Reinhold
   Birkfellner, Franz
   Perathoner, Alexander
   Raab, Helmut
   Nehoda, Hermann
   Pratschke, Johann
   Zitt, Matthias
TI Damage Control Surgery with Abdominal Vacuum and Delayed Bowel
   Reconstruction in Patients with Perforated Diverticulitis Hinchey III/IV
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Perforated; Diverticulitis; Hinchey; Abdominal; Vacuum; Anastomosis
ID LAPAROSCOPIC PERITONEAL-LAVAGE; HARTMANNS PROCEDURE; SIGMOID
   DIVERTICULITIS; PRIMARY ANASTOMOSIS; COMPLICATED DIVERTICULITIS;
   GENERALIZED PERITONITIS; ASSISTED CLOSURE; COLECTOMY; RESECTION;
   REVERSAL
AB With the use of abdominal vacuum therapy, we have developed a damage control concept for patients with perforated diverticulitis and generalized peritonitis. The primary aim of this concept was to enhance recovery and allow bowel reconstruction in a second-look operation.
   A total of 51 patients (28 female, 55 %) with a median (range) age of 69 (28-87) years, with perforated diverticulitis Hinchey III (n = 40, 78 %) or Hinchey IV (n = 11, 22 %) and a median (range) Mannheim peritonitis index of 26 (12-39), admitted between October 2006 and September 2011, were prospectively enrolled in the study. At initial operation, limited resection of the diseased segment, lavage, and application of abdominal vacuum-assisted closure dressing was performed. After patient resuscitation, a second look was performed in an elective setting.
   Hospital mortality rate was 9.8 %; 35 (76 %) of patients were discharged with reconstructed colon, and 93 % of patients live without a stoma at follow-up. Risk factors for mortality were American Society of Anesthesiologist score (p = 0.01), organ failure at initial presentation (p = 0.03), cardiac comorbidity (p = 0.05), and a Hartmann procedure at second look (p = 0.00).
   With this abdominal vacuum-based damage control concept, an acceptable hospital mortality rate and a high rate of bowel reconstruction at second look were achieved in patients with perforated diverticulitis and generalized peritonitis.
C1 [Kafka-Ritsch, Reinhold; Perathoner, Alexander; Pratschke, Johann; Zitt, Matthias] Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, A-6020 Innsbruck, Austria.
   [Birkfellner, Franz; Nehoda, Hermann] St Johann Tirol Hosp, A-6380 St Johann In Tirol, Austria.
   [Raab, Helmut] Innsbruck Med Univ, Dept Anaesthesiol, Ctr Operat Med, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Kafka-Ritsch, R (通讯作者)，Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Anichstr 35, A-6020 Innsbruck, Austria.
EM reinhold.kafka-ritsch@uki.at
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NR 27
TC 75
Z9 82
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD OCT
PY 2012
VL 16
IS 10
BP 1915
EP 1922
DI 10.1007/s11605-012-1977-4
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 008KF
UT WOS:000308955100014
PM 22843083
DA 2026-07-24
ER

PT J
AU Salazard, B
   Niddam, J
   Ghez, O
   Metras, D
   Magalon, G
AF Salazard, B.
   Niddam, J.
   Ghez, O.
   Metras, D.
   Magalon, G.
TI Vacuum-assisted clsoure in the treatment of poststernotomy mediastinitis
   in the paediatric patient
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT Congress of the French-Society-of-Plastic-Surgery
CY MAR, 2006
CL Brussels, BELGIUM
SP French Soc Plast Surg
DE mediastinitis; negative pressure therapy; sternal dehiscence treatment
ID MUSCLE FLAP; POSTOPERATIVE MEDIASTINITIS; CARDIAC-SURGERY; CLOSURE;
   INFECTION; CHILDREN; INFANT
AB Introduction: Delayed sternal closure after paediatric open heart procedure is often necessary. The risk of delayed sternal closure is infection: superficial wound or sternal and mediastinal infection. The incidence of sternal wound infection reported in the literature varies from 0.5 to 10%. The mortality for poststernotomy deep sternal infection continues to be high - from 14 to 47%. Established treatment includes surgical debridement, drainage and irrigation, antibiotics, frequent change of wound dressing and direct or secondary closure with omentum or pectoral muscle flap.
   Patients and methods: Between October 2003 and August 2005, three children, aged from 9 days to 2 years and who had developed severe mediastinitis after cardiac surgery were treated with the vacuum-assisted closure (VAC) system.
   Results: The duration of VAC treatment ranged from 12 to 21 days. The response to VAC was rapid with local purulence and C.-reactive protein (CRP) both decreasing within 72 h in all cases. After good granulation was obtained, two patients required a thin skin graft.
   Discussion: All three children had peritoneal dialysis which did not permit omental use. The use of pectoralis major is a difficult technique in neonates and the haemodynamic conditions were poor in our cases. The VAC technique is a good indication in post-cardiotomy mediastinitis in children: it plays a role in the reduction of infection and provides good heating. (c) 2007 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Salazard, B.; Niddam, J.; Magalon, G.] Timone Childrens Hosp, Dept Paediat Plast Surg, F-13385 Marseille 05, France.
   [Metras, D.] Timone Childrens Hosp, Dept Paediat Thorac & Cardiac Surg, F-13385 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Salazard, B (通讯作者)，Hop Conception, Serv Pr Magalon, 147 Blvd Baille, F-13385 Marseille 05, France.
EM bruno.salazard@wanadoo.fr
RI /AAF-1639-2019
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   Erez E, 2000, ANN THORAC SURG, V70, P1449, DOI 10.1016/S0003-4975(00)01869-5
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NR 11
TC 27
Z9 35
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PY 2008
VL 61
IS 3
BP 302
EP 305
DI 10.1016/j.bjps.2007.05.004
PG 4
WC Surgery
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 278FI
UT WOS:000254269600012
PM 17586108
DA 2026-07-24
ER

PT J
AU de Donato, G
   Setacci, F
   Galzerano, G
   Ruzzi, U
   Borrelli, MP
   Mazzitelli, G
   Setacci, C
AF de Donato, G.
   Setacci, F.
   Galzerano, G.
   Ruzzi, U.
   Borrelli, M. P.
   Mazzitelli, G.
   Setacci, C.
TI Prosthesis infection: prevention and treatment
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Heart bypass; Vascular grafting; Vascular surgery
ID AORTIC GRAFT INFECTION; VACUUM-ASSISTED CLOSURE; VASCULAR GRAFT;
   ENDOGRAFT INFECTION; ARTERIAL RECONSTRUCTION; CONSERVATIVE TREATMENT;
   AORTOENTERIC FISTULA; FEMOROFEMORAL BYPASS; SURGICAL-MANAGEMENT;
   MYCOTIC-ANEURYSMS
AB Implantation of a vascular prosthesis increases surgical site infection risk by producing a microenvironment conducive to bacterial attachment and biofilm formation, which sustains bacterial colonization and protects encased organisms from host defenses and antimicrobial therapy. Many maneuvers are used in an attempt to reduce infection in arterial reconstructions, but there are no clear guidelines on the most appropriate or effective. As well, there is no good evidence to guide management. A general principle is that indication for removal of the entire infected graft is mandatory when a suture line is involved in the infectious process, an infected anastomotic aneurism and a suture-line hemorrhage is evident, or when a graft-enteric fistula is diagnosed. Conservative, non-resectional management of graft infection is still a respectable solution for selected patients, as those with significant comorbidities, or those where the implanted aortic graft is in a location that precludes excision without causing a high likelihood of morbidity and/or mortality. Anyway, definitive management depends on the patient's condition and a tailored approach should be always offered. Surgical techniques favor in terms of mortality, patency and reinfection rate the in situ reconstruction. Currently, the choice of the technique used relies on center and operator's experience. This article summarizes the incidence of graft infection, analyze the predisponding factors to graft infection, and review current strategies for prevention and treatment of prosthesis and endograft infection.
C1 [de Donato, G.; Galzerano, G.; Ruzzi, U.; Borrelli, M. P.; Mazzitelli, G.; Setacci, C.] Univ Siena, Dept Med Surg & Neurosci, Vasc Surg Unit, I-53100 Siena, Italy.
   [Setacci, F.] Univ Roma La Sapienza, Dept Surg P Valdoni, I-00185 Rome, Italy.
C3 University of Siena; Sapienza University Rome
RP de Donato, G (通讯作者)，Univ Siena, Dept Med Surg & Neurosci, Vasc & Endovasc Surg Unit, Viale Bracci, I-53100 Siena, Italy.
EM dedonato@unisi.it
RI ; Setacci, Francesco/IQR-6320-2023; galzerano, giuseppe/AAC-7825-2022
OI Setacci, Carlo/0000-0002-7983-9209; Setacci,
   Francesco/0000-0002-8007-9462; 
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NR 114
TC 15
Z9 19
U1 0
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD DEC
PY 2014
VL 55
IS 6
BP 779
EP 792
PG 14
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AX3CL
UT WOS:000346818100006
PM 25017788
DA 2026-07-24
ER

PT J
AU Bellidenty, L
   Chastel, R
   Pluvy, I
   Pauchot, J
   Tropet, Y
AF Bellidenty, L.
   Chastel, R.
   Pluvy, I.
   Pauchot, J.
   Tropet, Y.
TI Emergency free flap in reconstruction of the lower limb. Thirty-five
   years of experience
SO ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
LA French
DT Article
DE Muscular free flaps; Lower limb trauma; Open leg fracture; Lower limb
   soft tissue defect
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES;
   LOWER-EXTREMITY; COVERAGE; MANAGEMENT; DEFECTS; LEG
AB Authors analyzed 89 cases (86 patients) of lower limb extensive soft tissue defects reconstruction during 1978 to 2013. The mean age is 37 years and 2 months old (range: 5-84 years old). A total of 71 males and 15 female were included. Free flaps were used in emergency in 23 cases for principally covering Gustilo 3B open lower limb fracture and in a later stage for 66 cases all referred from their center for coverage of exposed bone, with frequently osteomyelitis. About the selection of free flaps, in 47 cases we used a latissimus dorsi flaps, 12 cases of epiploon free transfer (in septic area), 10 cases of gracilis transfer and 10 serratus anterior flaps. There are one medial gastrocnemius flap, 2 composite soleus and fibular free flap, 2 antebrachial flap, one inguinal myoosteocutaneous flap, 1 transferred from the other lower limb and one inguinal cutaneous flap. There are 18 free flap losses: one in emergency and 17 after delayed reconstruction. Authors retrospectively analyzed the results (complications, osteomyelitis) according to the timing for lower extremity reconstruction. They found a low infection and flap failure rates (4%) when the coverage is made in the same operating time than initial fracture fixation, they increase to 60% for osteomyelitis and to 23% for flap failure when the reconstruction is delayed. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Bellidenty, L.; Chastel, R.; Pluvy, I.; Pauchot, J.; Tropet, Y.] Serv Chirurg Orthoped Traumatol Plast Esthet & Re, F-25000 Besancon, France.
RP Bellidenty, L (通讯作者)，Serv Chirurg Orthoped Traumatol Plast Esthet & Re, Blvd Fleming, F-25000 Besancon, France.
EM lydiane.bellidenty@laposte.net
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NR 31
TC 20
Z9 23
U1 0
U2 3
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0294-1260
EI 1768-319X
J9 ANN CHIR PLAST ESTH
JI Ann. Chir. Plast. Esthet.
PD FEB
PY 2014
VL 59
IS 1
BP 35
EP 41
DI 10.1016/j.anplas.2013.08.004
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 302BK
UT WOS:000330576100006
PM 24051126
DA 2026-07-24
ER

PT J
AU Zhen, ZJ
   Lai, ECH
   Lee, QH
   Chen, HW
   Lau, WY
   Wang, FJ
AF Zhen, Zuo Jun
   Lai, Eric C. H.
   Lee, Qing Han
   Chen, Huan Wei
   Lau, Wan Yee
   Wang, Feng Jie
TI Conventional wound management versus a closed suction irrigation method
   for infected laparotomy wound - A comparative study
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Wound infection; Dirty wound; Closed suction irrigation method; Surgical
   site infection; Dressing
ID VACUUM-ASSISTED CLOSURE; THERAPY
AB Objective: The aim of this study was to evaluate the efficacy of a closed suction irrigation method for the management of infected laparotomy wounds.
   Methods: This is a retrospective study on consecutive patients with infected laparotomy wounds managed in a single tertiary referral hospital from January 2004 to March 2009. The wounds were laid open, debrided and cleansed with hydrogen peroxide, povidone iodine and normal saline. The wounds were either conventionally treated with normal saline dressings followed by secondary suturing when healthy granulation tissues were formed (the Control group) or by the closed suction irrigation method after suturing the wound (the Study Group).
   Results: There were 70 patients in the Study Group and 60 patients in the Control Group. The hospital stay (mean +/- SD, 9.2 +/- 0.1 vs. 20.5 +/- 0.6 days, P < 0.001) and time to wound healing (mean +/- SD, 8.1 +/- 0.1 vs. 18.5 +/- 0.6 days, P < 0.001) were significantly better in the Study Group than in the Control Group. The re-infection rate was also significantly lower in the Study Group (7.1% vs. 21.7%, P < 0.05).
   Conclusions: Encouraging results were obtained with the use of the closed suction irrigation method for infected laparotomy wounds. The closed suction irrigation method decreased hospital stay and allowed early rehabilitation. The findings of our study need to be substantiated in large-scale randomized controlled trials. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Zhen, Zuo Jun; Lai, Eric C. H.; Lau, Wan Yee] Chinese Univ Hong Kong, Fac Med, Shatin, Hong Kong, Peoples R China.
   [Zhen, Zuo Jun; Lai, Eric C. H.; Lee, Qing Han; Chen, Huan Wei; Lau, Wan Yee; Wang, Feng Jie] First Peoples Hosp Foshan, Dept Hepatobiliary Surg, Foshan 528000, Guang Dong, Peoples R China.
C3 Chinese University of Hong Kong
RP Zhen, ZJ (通讯作者)，Chinese Univ Hong Kong, Fac Med, Shatin, Hong Kong, Peoples R China.
EM zzjun@fsyyy.com; josephlau@cuhk.edu.hk
RI Lee, Qing/LBI-6618-2024; LAI, Eric C.H/B-5162-2008
OI LAI, Eric C.H/0000-0001-6551-9231
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NR 7
TC 6
Z9 9
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 5
BP 378
EP 381
DI 10.1016/j.ijsu.2011.02.012
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 832BZ
UT WOS:000295776800005
PM 21371577
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjoe, Malin
   Ingemansson, Richard
TI Blood flow changes in normal and ischemic myocardium during topically
   applied negative pressure
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STERNAL WOUND-INFECTION; LONG-TERM SURVIVAL;
   PERISTERNAL THORACIC WALL; RISK-FACTORS; REVASCULARIZATION;
   MEDIASTINITIS; THERAPY; COMPLICATIONS; IMPACT
AB Background. Topical negative pressure (TNP) therapy has been adopted as a first-line treatment for wound healing. One of the mechanisms by which TNP improves healing is by stimulating blood flow to the wound edge. Among patients with ischemic heart disease, it is of great importance to improve the microvascular blood flow in the myocardium during episodes of ischemia to protect the myocardium from infarction. The present study was designed to elucidate the effect of TNP on microvascular blood flow in the myocardium.
   Methods. Six pigs underwent median sternotomy. The microvascular blood flow in the myocardium was recorded, before and after the application of TNP, by using laser Doppler velocimetry. Analyses were performed before left anterior descending artery ( LAD) occlusion ( normal myocardium), after 20 minutes of LAD occlusion ischemic myocardium), and after 20 minutes of reperfusion (reperfused myocardium).
   Results. TNP at -0 mm Hg increased microvascular blood flow in the normal myocardium from 14.7 +/- 3.9 perfusion units (PU) before to 25.8 +/- 6.1 PU after TNP application ( p < 0.05), in the ischemic myocardium from 7.2 +/- 1.5 PU before to 13.8 +/- 2.6 PU after TNP application ( p < 0.05), and in the reperfused myocardium from 10.8 +/- 2.0 PU before to 19.3 +/- 5.6 PU after TNP application ( p < 0.05).
   Conclusions. TNP increases the microvascular blood flow significantly in normal, ischemic, and reperfused myocardium and may provide a novel therapeutic tool in the treatment of ischemic myocardium.
C1 Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Ingemansson,
   Richard/0000-0001-7623-8953; Maljö, Malin/0000-0001-9849-9599
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NR 32
TC 27
Z9 39
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD AUG
PY 2007
VL 84
IS 2
BP 568
EP 573
DI 10.1016/j.athoracsur.2007.02.066
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 192HS
UT WOS:000248192400030
PM 17643636
DA 2026-07-24
ER

PT J
AU Donovan, TJ
   Sino, S
   Paraforos, A
   Leick, J
   Friedrich, I
AF Donovan, Terrence John
   Sino, Safwan
   Paraforos, Alexandros
   Leick, Juergen
   Friedrich, Ivar
TI Topical Vancomycin Reduces the Incidence of Deep Sternal Wound
   Complications After Sternotomy
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MEDIAN STERNOTOMY; CARDIAC-SURGERY;
   RISK-FACTORS; MANAGEMENT; MEDIASTINITIS; INFECTION; OSTEOBLASTS
AB BACKGROUND Deep sternal wound infection remains a significant hazard for cardiosurgical patients undergoing median sternotomy. Although the prophylactic use of topical vancomycin to reduce the incidence of deep sternal wound complications (DSWC) has been repeatedly examined, the method remains controversial.METHODS We report here on a continuous experience that encompassed a total of 1251 cardiosurgical patients who underwent various procedures via median sternotomy. Beginning in October 2015 and in response to a surge of DSWC (4.4%), 3 surgeons on our team began to apply 2.5 g vancomycin paste to the sternal edges just prior to closure, while the remaining 2 surgeons did not. An interim analysis comparing the 2 groups suggested that vancomycin was indeed effective, and from February 2016 on, all surgeons adopted the routine use of vancomycin in all patients.RESULTS Retrospective analysis of 496 surgical patients from January to September 2015 had revealed a baseline incidence of DSWC of 4.4%. In the divided-use period between October 2015 and February 2016, DSWC was seen in 8.6% (8 of 93) of the no-vancomycin group. In the vancomycin group, the incidence fell to 0.8% (1 of 129). In March 2016, all surgeons began using vancomycin and the overall rate of DSWC for all surgeons and all patients subsequently declined to 1.1%. No adverse effects were observed. CONCLUSIONS Topical vancomycin application is highly effective in the prevention of DSWC after median sternotomy.
C1 Krankenhaus Barmherzigen Bruder Trier, Dept Cardiothorac Surg, Herzzentrum Trier, Trier, Germany.
   Krankenhaus Barmherzigen Bruder, Dept Cardiol, Herzzentrum Trier, Trier, Germany.
RP Donovan, TJ (通讯作者)，Krankenhaus Barmherzigen BrUder Trier, Herzzentrum Trier, Nordallee 1, D-54293 Trier, Germany.
EM tj.donovan@bk-trier.de
RI Leick, Juergen/KRO-8300-2024
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NR 34
TC 21
Z9 23
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD AUG
PY 2022
VL 114
IS 2
BP 511
EP 518
DI 10.1016/j.athoracsur.2021.09.036
EA JUL 2022
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 5E1XO
UT WOS:000865422000026
PM 34695404
DA 2026-07-24
ER

PT J
AU Cooper, HJ
   Bas, MA
AF Cooper, H. John
   Bas, Marcel A.
TI Closed-Incision Negative-Pressure Therapy Versus Antimicrobial Dressings
   After Revision Hip and Knee Surgery: A Comparative Study
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE closed-incision negative-pressure therapy; surgical site infections;
   prevention; hip revision; knee revision; quality improvement
ID TOTAL JOINT ARTHROPLASTY; SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED
   CLOSURE; WOUND THERAPY; UNITED-STATES; HIGH-RISK; COST-EFFECTIVENESS;
   PREVENTION; MANAGEMENT; FRACTURES
AB Background: This study evaluates the efficacy of closed-incision negative-pressure therapy (ciNPT) in decreasing wound complications and surgical site infections (SSIs) after revision hip and knee surgery.
   Methods: A retrospective quality improvement analysis of 138 consecutive revision hip and knee operations performed by a single surgeon over a 34-month period was performed. ciNPT was used selectively in higher-risk patients with multiple risk factors for SSIs over the last 15 months of the study period. Rates of wound complications, SSIs, and reoperation were compared with patients treated with a sterile antimicrobial dressing.
   Results: Antimicrobial dressings were used in 108 patients, whereas ciNPT was used in 30 patients. Patients treated with ciNPT developed fewer overall wound complications (6.7% vs 26.9%, P = .024) and fewer total SSIs (3.3% vs 18.5%, P = .045) than patients treated with antimicrobial dressings. In addition, there were trends toward a lower rate of superficial wound dehiscence (6.7% vs 19.4%, P = .163), fewer deep periprosthetic joint infections (0.0% vs 9.3%, P = .118), and fewer reoperations (3.3% vs 13.0%, P = .191) among patients treated with ciNPT.
   Conclusion: Our findings suggest that ciNPT may decrease wound complications and SSIs in patients undergoing revision hip and knee surgery. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Cooper, H. John; Bas, Marcel A.] Lenox Hill Hosp, North Shore LIJ Hlth Syst, Dept Orthopaed Surg, Div Adult Reconstruct, New York, NY 10075 USA.
C3 Northwell Health
RP Cooper, HJ (通讯作者)，Lenox Hill Hosp, Dept Orthopaed Surg, 130 East 77th St,11th Floor, New York, NY 10075 USA.
RI Cooper, Herbert/H-3488-2019
OI Cooper, Herbert/0000-0002-9272-668X
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NR 46
TC 79
Z9 88
U1 0
U2 12
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD MAY
PY 2016
VL 31
IS 5
BP 1047
EP 1052
DI 10.1016/j.arth.2015.11.010
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA DL2KK
UT WOS:000375463400024
PM 26712346
DA 2026-07-24
ER

PT J
AU Citro, R
   Prota, C
   Greco, L
   Mirra, M
   Masullo, A
   Silverio, A
   Bossone, E
   Piscione, F
AF Citro, Rodolfo
   Prota, Costantina
   Greco, Luigi
   Mirra, Marco
   Masullo, Alfonso
   Silverio, Angelo
   Bossone, Eduardo
   Piscione, Federico
TI Kocuria kristinae endocarditis related to diabetic foot infection
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Article
ID CATHETER-RELATED BACTEREMIA; MICROCOCCUS; PATIENT
AB We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 degrees C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confirmed by 16S rRNA gene sequencing. Transthoracic echocardiographic examination showed the presence of a large vegetation (38x20 mm) on the posterior mitrel leaflet and moderate mitral regurgitation. Since there are no current guidelines for the treatment of K. kristinae endocarditis, empiric antibiotic therapy with intravenous sulbactam/ampicillin (1.5 g twice daily) and gentamicin (6 mg kg(-1) per day) was started. After 7 days of hospitalization, the patient's condition suddenly worsened because of the occurrence of haemorrhagic stroke. Despite inotropic support and rifampicin infusion, the haemodynamic status progressively deteriorated. After an initial improvement, he worsened again, becoming stuporous, hypotensive and dyspnoeic. In the following days, the patient developed compartment syndrome resulting in right foot ischaemia. Unfortunately, 25 days after hospitalization, the patient died of multiple organ failure from overwhelming sepsis. To the best of our knowledge, this is the first case of K. kristinae endocarditis on a native valve that is not related to a central venous catheter but associated with diabetic foot infection.
C1 [Citro, Rodolfo; Prota, Costantina; Mirra, Marco; Silverio, Angelo; Bossone, Eduardo; Piscione, Federico] Univ Hosp San Giovanni di Dio e Ruggi dAragona, Heart Dept, Salerno, Italy.
   [Greco, Luigi; Masullo, Alfonso] Univ Hosp San Giovanni di Dio e Ruggi dAragona, UOC Malattie Infett, Salerno, Italy.
RP Citro, R (通讯作者)，Univ Hosp San Giovanni di Dio e Ruggi dAragona, Heart Dept, Salerno, Italy.
EM rodolfocitro@gmail.it
RI Citro, Rodolfo/Q-5242-2016; Silverio, Angelo/AAS-2810-2020; Bossone,
   Eduardo/Z-1305-2019; Mirra, Marco/KFB-5400-2024
OI Citro, Rodolfo/0000-0002-7796-6298; Silverio,
   Angelo/0000-0001-9749-8092; Bossone, Eduardo/0000-0003-2769-9950; 
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   STACKEBRANDT E, 1995, INT J SYST BACTERIOL, V45, P682, DOI 10.1099/00207713-45-4-682
NR 9
TC 28
Z9 31
U1 0
U2 5
PU MICROBIOLOGY SOC
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER ST, LONDON WC1N 2JU, ERKS, ENGLAND
SN 0022-2615
EI 1473-5644
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PD JUN
PY 2013
VL 62
BP 932
EP 934
DI 10.1099/jmm.0.054536-0
PN 6
PG 3
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 174IP
UT WOS:000321149200019
PM 23518651
DA 2026-07-24
ER

PT J
AU Tannous, O
   Griffith, C
   O'Toole, RV
   Pellegrini, VD
AF Tannous, Oliver
   Griffith, Cullen
   O'Toole, Robert V.
   Pellegrini, Vincent D., Jr.
TI Heterotopic Ossification After Extremity Blast Amputation in a
   Sprague-Dawley Rat Animal Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE heterotopic ossification; extremity blast amputation; military trauma
ID VACUUM-ASSISTED CLOSURE; BONE; FOUNDATION; INJURIES
AB Objective: To create an animal survival model for heterotopic ossification (HO) in the residual limb of the rat after extremity blast amputation. The hypothesis was that extremity blast amputation spontaneously stimulates development of HO in the residual limb.
   Methods: Twelve Sprague-Dawley rats underwent localized exposure to a controlled, high-energy blast. Seven rats were designated for hind limb amputation and five for forelimb amputation. Our protocol produced extremity amputation through detonation of an explosive while protecting the animal proximal to the specified amputation level. Immediately after injury, the rat underwent wound management and primary surgical closure. Radiographs of the amputated limbs were obtained every 2 weeks. Heterotopic bone was radiographically classified as periosteal growth (Type A) or noncontiguous growth (Type B). A kappa statistic was calculated for interobserver strength of agreement on the presence of HO. Fisher exact test was conducted to assess the significance of the difference in hind limb and forelimb HO rates.
   Results: Nine of 12 animals survived the procedure. The three nonsurvivors were all hind limb amputees, and each died of various related causes. All four surviving hind limb amputees exhibited Type A HO, and three of four also exhibited Type B HO within the injured stump. One of five forelimb amputees exhibited Types A and B HO.
   Conclusions: We have developed a reproducible model for HO in the residual limbs of blast-amputated rats without addition of exogenous osteogenic stimulus. Hind limb amputation demonstrated a predilection for HO formation in comparison with forelimb amputation (P < 0.05).
C1 [Pellegrini, Vincent D., Jr.] Univ Maryland, Med Ctr, Sch Med, Dept Orthopaed, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Pellegrini, VD (通讯作者)，Univ Maryland, Med Ctr, Sch Med, Dept Orthopaed, 22 S Greene St,Suite S11B, Baltimore, MD 21201 USA.
EM vpellegrini@umoa.umm.edu
RI OToole, Robert/HKN-8717-2023
FU Orthopaedic Trauma Association
FX This research was funded, in part, by an AO North America grant from the
   Orthopaedic Trauma Association.
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NR 28
TC 30
Z9 34
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD AUG
PY 2011
VL 25
IS 8
BP 506
EP 510
DI 10.1097/BOT.0b013e31821f6265
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 794BQ
UT WOS:000292870300012
PM 21738069
DA 2026-07-24
ER

PT J
AU Friedrich, JB
   Petrov, RV
   Askay, SAW
   Clark, MP
   Foy, HA
   Isik, FF
   Dellinger, EP
   Klein, MB
   Engrav, LH
AF Friedrich, Jeffrey B.
   Petrov, Roman V.
   Askay, Shelley A. Wiechman
   Clark, Molly P.
   Foy, Hugh A.
   Isik, F. Frank
   Dellinger, E. Patchen
   Klein, Matthew B.
   Engrav, Loren H.
TI Resection of panniculus morbidus: A salvage procedure with a steep
   learning curve
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ABDOMINOPLASTY; ADJUVANT; SURGERY
AB Background: A subset of obese people develop a pannus hanging to the floor. This panniculus morbidus prevents weight loss, as the patient cannot exercise. It prevents hygiene, leading to a profound odor and ultimately results in intertrigo, cellulitis, and/or abdominal ulceration. The only two options are to live/die with it or resect it. Some of these people are otherwise ready for a weight loss program. For this group, resection of the panniculus morbidus may be indicated. The authors reviewed the literature and found the condition has not been addressed in this journal since 1994 and was not considered in the recent supplement on body contouring. In 1998, the authors began resecting panniculus morbidus for this small group. The authors found the learning curve to be profoundly steep, with many wound complications, a finding that is quite in conflict with the literature on the subject, and decided to present their experience.
   Methods: The authors conducted a retrospective chart review of 23 patients and collected data on demographics, ambulation, hygiene, technique, complications, and outcome.
   Results: The technique of closure evolved as the authors struggled with complications. The current method of closure is three suture layers over four suction drains with a small wound vacuum-assisted closure device at each end of the incision. All patients ultimately healed and found it easier to ambulate and perform hygiene.
   Conclusion: Resection of panniculus morbidus is a beneficial salvage procedure for some morbidly obese people, but the learning curve is steep and the current literature is misleading.
C1 [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Univ Washington, Harborview Med Ctr, Dept Surg, Div Plast Surg, Seattle, WA 98104 USA.
   [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
   [Friedrich, Jeffrey B.; Petrov, Roman V.; Askay, Shelley A. Wiechman; Clark, Molly P.; Foy, Hugh A.; Isik, F. Frank; Dellinger, E. Patchen; Klein, Matthew B.; Engrav, Loren H.] Harborview Med Ctr, Dept Hosp & Nutr, Seattle, WA USA.
C3 University of Washington; University of Washington Seattle; Harborview
   Medical Center; University of Washington; University of Washington
   Seattle; Harborview Medical Center
RP Engrav, LH (通讯作者)，Univ Washington, Harborview Med Ctr, Dept Surg, Div Plast Surg, Box 359796,325 9th Ave, Seattle, WA 98104 USA.
EM engrav@u.washington.edu
RI Petrov, Roman/GXV-4075-2022; Dellinger, E./AFZ-2144-2022
OI Friedrich, Jeffrey/0000-0002-5245-9708
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NR 25
TC 19
Z9 22
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2008
VL 121
IS 1
BP 108
EP 114
DI 10.1097/01.prs.0000293760.41152.29
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 249DZ
UT WOS:000252208700015
PM 18176212
DA 2026-07-24
ER

PT J
AU Plum, PS
   Herbold, T
   Berlth, F
   Christ, H
   Alakus, H
   Bludau, M
   Chang, DH
   Bruns, CJ
   Hölscher, AH
   Chon, SH
AF Plum, Patrick Sven
   Herbold, Till
   Berlth, Felix
   Christ, Hildegard
   Alakus, Hakan
   Bludau, Marc
   Chang, De-Hua
   Bruns, Christiane Josephine
   Hoelscher, Arnulf Heinrich
   Chon, Seung-Hun
TI Outcome of Self-Expanding Metal Stents in the Treatment of Anastomotic
   Leaks After Ivor Lewis Esophagectomy
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ROUTINE CONTRAST ESOPHAGRAM; VACUUM-ASSISTED CLOSURE; MANAGEMENT;
   ESOPHAGOGASTRECTOMY; COMPLICATIONS; EFFICACY; SURGERY; IMPACT
AB BackgroundEsophageal anastomotic leakages after Ivor Lewis esophagectomy are severe and life-threatening complications. We analyzed the outcome of using self-expanding metal stents (SEMS) in the treatment of postoperative leakage afteresophagogastrostomy.MethodsSeventy patients with esophageal anastomotic leakage after Ivor Lewis esophagectomy for esophageal cancer who had received SEMS treatment between January 2006 and December 2015 at our clinic were identified in this retrospective study. The patients were analyzed according to demographic characteristics, risk factors, leakage characteristics, stent characteristics, stent-related complications, sealing success rate and mortality.ResultsOver a 10-year period, 70 patients received SEMS as treatment for postoperative anastomotic leakage after esophagectomy. Technical success of esophageal stenting in anastomotic leakage was achieved in 50 out of 70 cases (71.4%). Sealing success rate was 70% (n=49) with a median treatment of 28days (range 7-87). In 20 patients (28.6%), stent-related complications, such as stenosis, dislocation, leakage persistence, perforation or esophagotracheal fistula occurred after the SEMS treatment. Sixty-one patients (87.1%) survived SEMS treatment of esophagogastric anastomotic leakage. Mean follow-up for all patients was 38months (IQR 10-76), and no significant difference was found in a comparison of the long-term survival rate between patients with successful and unsuccessful SEMS treatment.ConclusionsThe management of esophageal anastomotic leaks after Ivor Lewis esophagectomy with SEMS is effective, safe and technically feasible. Aggressive non-surgical management should be considered when developing a treatment plan for stenting.
C1 [Plum, Patrick Sven; Berlth, Felix; Alakus, Hakan; Bludau, Marc; Bruns, Christiane Josephine; Chon, Seung-Hun] Univ Hosp Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
   [Herbold, Till] Rhein Westfal TH Aachen, Dept Gen Visceral & Transplantat Surg, Aachen, Germany.
   [Christ, Hildegard] Univ Cologne, Inst Med Stat & Bioinformat, Cologne, Germany.
   [Chang, De-Hua] Univ Hosp Cologne, Inst Radiol, Cologne, Germany.
   [Hoelscher, Arnulf Heinrich] AGAPLESION Markus Krankenhaus, Ctr Esophageal & Gastr Surg, Frankfurt, Germany.
C3 University of Cologne; RWTH Aachen University; University of Cologne;
   University of Cologne
RP Chon, SH (通讯作者)，Univ Hosp Cologne, Dept Gen Visceral & Canc Surg, Kerpener Str 62, D-50937 Cologne, Germany.
EM Seung-Hun.Chon@uk-koeln.de
RI Plum, PD Dr. med. Patrick Sven/AAG-4064-2020; Chon,
   Seung-Hun/PHE-1824-2026; Chang, De-Hua/KBA-8962-2024
OI Plum, PD Dr. med. Patrick Sven/0000-0002-8165-4553; Chon,
   Seung-Hun/0000-0002-8923-6428; Christ, Hildegard/0000-0003-3235-2994; 
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NR 35
TC 42
Z9 53
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD MAR
PY 2019
VL 43
IS 3
BP 862
EP 869
DI 10.1007/s00268-018-4832-2
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HJ8NE
UT WOS:000457455400024
PM 30377723
OA Bronze
DA 2026-07-24
ER

PT J
AU Yang, JM
   Chen, SW
   Yang, JH
   Hsu, CC
   Wang, JS
AF Yang, Jen Ming
   Chen, Szi-Wen
   Yang, Jhe-Hao
   Hsu, Chih-Chin
   Wang, Jong-Shyan
TI A quantitative cell modeling and wound-healing analysis based on the
   Electric Cell-substrate Impedance Sensing (ECIS) method
SO COMPUTERS IN BIOLOGY AND MEDICINE
LA English
DT Article
DE Electric Cell-substrate Impedance Sensing (ECIS); Modeling; Negative
   pressure; Wound healing
ID VACUUM-ASSISTED CLOSURE; BARRIER FUNCTION; REAL-TIME; CYTOTOXICITY;
   ADHESION; RECEPTOR; THERAPY; GROWTH; GENE
AB In this paper, a quantitative modeling and wound-healing analysis of fibroblast and human keratinocyte cells is presented. Our study was conducted using a continuous cellular impedance monitoring technique, dubbed Electric Cell-substrate Impedance Sensing (ECIS). In fact, we have constructed a mathematical model for quantitatively analyzing the cultured cell growth using the time series data directly derived by ECIS in a previous work. In this study, the applicability of our model into the keratinocyte cell growth modeling analysis was assessed first. In addition, an electrical "wound-healing" assay was used as a means to evaluate the healing process of keratinocyte cells at a variety of pressures. Two innovative and new-defined indicators, dubbed cell power and cell electroactivity, respectively, were developed for quantitatively characterizing the biophysical behavior of cells. We then employed the wavelet transform method to perform a multi-scale analysis so the cell power and cell electroactivity across multiple observational time scales may be captured. Numerical results indicated that our model can well fit the data measured from the keratinocyte cell culture for cell growth modeling analysis. Also, the results produced by our quantitative analysis showed that the wound healing process was the fastest at the negative pressure of 125 mmHg, which consistently agreed with the qualitative analysis results reported in previous works. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Yang, Jen Ming] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan, Taiwan.
   [Chen, Szi-Wen; Yang, Jhe-Hao] Chang Gung Univ, Dept Elect Engn, Taoyuan, Taiwan.
   [Chen, Szi-Wen] Chang Gung Univ, HARC, Taoyuan, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Wang, Jong-Shyan] Chang Gung Univ, Dept Phys Therapy, Taoyuan, Taiwan.
   [Wang, Jong-Shyan] Chang Gung Univ, Grad Inst Rehabil Sci, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung University; Chang Gung University;
   Chang Gung Memorial Hospital; Chang Gung University; Chang Gung
   University; Chang Gung University
RP Yang, JM (通讯作者)，Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan, Taiwan.; Chen, SW (通讯作者)，Chang Gung Univ, Dept Elect Engn, Taoyuan, Taiwan.
EM jmyang@mail.cgu.edu.tw; chensw@mail.cgu.edu.tw
OI Chen, Szi-Wen/0000-0001-6171-0493; Wang, Jong-Shyan/0000-0002-3095-9357
FU Chang Gung Memorial Hospital [CMRPD1C0131, CMRPD1C0132]
FX We thank the Chang Gung Memorial Hospital for Grants (CMRPD1C0131,
   CMRPD1C0132) to support this study.
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NR 39
TC 16
Z9 20
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0010-4825
EI 1879-0534
J9 COMPUT BIOL MED
JI Comput. Biol. Med.
PD FEB 1
PY 2016
VL 69
BP 134
EP 143
DI 10.1016/j.compbiomed.2015.12.022
PG 10
WC Biology; Computer Science, Interdisciplinary Applications; Engineering,
   Biomedical; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Computer Science;
   Engineering; Mathematical & Computational Biology
GA DF2QH
UT WOS:000371188400014
PM 26773459
DA 2026-07-24
ER

PT J
AU Ramser, M
   Nennstiel, S
   Mueller, M
   Schlag, C
   Turina, M
AF Ramser, Michaela
   Nennstiel, Simon
   Mueller, Matteo
   Schlag, Christoph
   Turina, Matthias
TI Vacuum-assisted self-expanding stents in colorectal surgery: early
   experiences with a novel tool
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Anastomosis; Anastomotic leak; VAC; Stent; Prophylactic; Therapeutic;
   Colorectal cancer; Colon resection
ID LOW ANTERIOR RESECTION; ANASTOMOTIC LEAKAGE; MANAGEMENT; CANCER
AB BackgroundAnastomotic leakage (AL) remains a dreaded complication following colorectal resections. The routine use of diverting loop ileostomies (DLI), is associated with significant morbidity, triggering interest in alternative strategies. The VACStent Colon (VSC), a novel endoscopic treatment, combines vacuum-assisted closure with a self-expanding stent, providing luminal patency. Here we report our 1-year experience with the VSC.MethodsRetrospective analysis of patients treated with VSC at our department from 02/2024 to 03/2025 either therapeutically for AL or prophylactically in high-risk anastomoses. Outcomes, including continuous luminal patency by VSC, AL healing, complications, and need for DLI, were assessed with follow-up until endoscopic healing (EH) of AL.ResultsThirteen patients received a total of 47 VSC. Continuous luminal patency was achieved in 89.4%. Overall, 10 patients were treated with therapeutic intent (43 VSC). Nine patients achieved EH under VSC therapy (6 with DLI close, 2 awaiting DLI, one managed without DLI). One patient did not achieve EH. Three patients underwent prophylactic VSC therapy following high-risk anastomoses without a DLI. Notably, no AL occurred in this group. The most commonly observed complication was pain, particularly in distally placed VSC. Outpatient VSC therapy was successfully implemented in select cases.ConclusionVSC shows promising results as therapeutic tool for treating colorectal AL and as prophylactic measure in high-risk anastomoses. It offers the benefits of vacuum therapy combined with mechanical stenting providing luminal patency, potentially reducing the need for DLI.
C1 [Ramser, Michaela; Mueller, Matteo; Turina, Matthias] Univ Hosp Zurich, Dept Visceral and Transplant Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
   [Nennstiel, Simon; Schlag, Christoph] Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Turina, M (通讯作者)，Univ Hosp Zurich, Dept Visceral and Transplant Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM matthias.turina@usz.ch
RI Schlag, Christoph/KXR-8170-2024
FU University of Zurich
FX Open access funding provided by University of Zurich. The authors
   received no funding for this research.
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NR 23
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD NOV
PY 2025
VL 39
IS 11
BP 7356
EP 7365
DI 10.1007/s00464-025-12116-2
EA AUG 2025
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9TH6G
UT WOS:001563171600001
PM 40877630
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Vos, RJ
   Van Putte, BP
   Kloppenburg, GTL
AF Vos, R. J.
   Van Putte, B. P.
   Kloppenburg, G. T. L.
TI Prevention of deep sternal wound infection in cardiac surgery: a
   literature review
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Review
DE Infection; Mediastinum; Sternum; Wound healing
ID SURGICAL-SITE-INFECTIONS; CORONARY-ARTERY-BYPASS; OPEN-HEART-SURGERY;
   VACUUM-ASSISTED CLOSURE; STAPHYLOCOCCUS-AUREUS INFECTIONS;
   POST-STERNOTOMY MEDIASTINITIS; RANDOMIZED MULTICENTER TRIAL;
   GENTAMICIN-COLLAGEN SPONGE; BLIND CONTROLLED-TRIAL; HIGH-RISK PATIENTS
AB Background: Deep sternal wound infection (DSWI) is a dreaded complication of cardiac surgery with considerable consequences in terms of mortality, morbidity and treatment costs. In addition to standard surgical site infection prevention guidelines, multiple specific measures in the prevention of DSWI have been developed and evaluated in the past decades. This review focuses on these specific measures to prevent DSWI.
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   Results: From a total of 743 articles found, 48 randomized controlled trials were selected. Studies were divided into 12 categories, containing pre-, peri-and postoperative preventive measures. Specific measures shown to be effective were: antibiotic prophylaxis with a first-generation cephalosporin for at least 24 h, application of local gentamicin before chest closure, sternal closure with figure-of-eight steel wires, and postoperative chest support using a corset or vest.
   Conclusion: This study identified several measures that prevent DSWI after cardiac surgery that are not frequently applied in current practice. It is recommended that the guidelines on prevention of surgical site infection in cardiac surgery should be updated. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Vos, R. J.; Van Putte, B. P.; Kloppenburg, G. T. L.] St Antonius Hosp, Dept Cardiothorac Surg, Koekoekslaan 1,Mailbox 2500, NL-3430 EM Nieuwegein, Netherlands.
   [Vos, R. J.; Van Putte, B. P.] Acad Med Ctr, Dept Cardiothorac Surg, Amsterdam, Netherlands.
C3 St. Antonius Hospital Utrecht; University of Amsterdam; Academic Medical
   Center Amsterdam
RP Vos, RJ (通讯作者)，St Antonius Hosp, Dept Cardiothorac Surg, Koekoekslaan 1,Mailbox 2500, NL-3430 EM Nieuwegein, Netherlands.
EM roemervos@gmail.com
OI Vos, Roemer/0000-0002-2511-988X
CR [Anonymous], CLIN MICROBIOL INFEC
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NR 77
TC 56
Z9 74
U1 1
U2 11
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD DEC
PY 2018
VL 100
IS 4
BP 411
EP 420
DI 10.1016/j.jhin.2018.05.026
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA HA2TF
UT WOS:000450096100019
PM 29885873
DA 2026-07-24
ER

PT J
AU Villa, R
   Costa, S
   Focchi, S
   Corbellini, C
   Vigorelli, M
   Avesani, EC
AF Villa, Roberta
   Costa, Stefano
   Focchi, Sibilla
   Corbellini, Carlo
   Vigorelli, Massimo
   Avesani, Ettore Contessini
TI Successful open abdomen treatment for multiple ischemic duodenal
   perforated ulcers in dermatomyositis
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Dermatomyositis; Duodenal perforations; Retroperitoneal air; Intestinal
   ischemia; Acute abdomen; Emergency surgery; Open abdomen
ID JUVENILE DERMATOMYOSITIS; MANIFESTATION; MANAGEMENT; THERAPY
AB Introduction: Dermatomyositis is an autoimmune disease characterized by proximal myopathy, cutaneous Gottron papules and heliotrope rash; intestinal involvement associated to acute vasculitis is less common but could be a life-threatening condition.
   Methods: A 21-year-old woman, affected by dermatomyositis, presented to our attention with a three-day story of severe abdominal pain, no bowel movement and biliary vomit. She was diagnosed with acute abdomen. A CT scan with bowel contrast demonstrated the presence of a leakage from the retroperitoneal aspect of duodenum. The surgical and clinical management in the light of literature review is presented.
   Results: Our first approach consisted in primary repair of the duodenal perforation with omentopexy. Post-operative course was complicated by hemorrhage. A reintervention showed a new perforation associated with multiple ischemic intestinal areas. We performed a gastroenteric anastomosis with functional exclusion of the damaged duodenum and positioning of drainages to create a biliary fistula. A nutritional enteric tube and an open abdomen vacuum-assisted closure system to monitor the fistula creation and to prevent abdominal contamination and collections were positioned. To reduce the amount of biliary leakage, a percutaneous transhepatic biliary drainage was placed, with progressive fistula flow disappearance in four months.
   Conclusions: In patients with dermatomyositis, when clinical findings and symptoms suggest abdominal vasculitis, it is very important to be aware of the risk of bowel and particularly duodenal perforations. Open abdomen treatment favors control of contamination by gastrointestinal contents, offers temporary abdominal closure, helps ICU care and delays definitive surgery.
C1 [Villa, Roberta; Costa, Stefano; Focchi, Sibilla; Corbellini, Carlo; Vigorelli, Massimo; Avesani, Ettore Contessini] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Gen & Emergency Surg, Milan, Italy.
   [Villa, Roberta; Focchi, Sibilla; Corbellini, Carlo; Avesani, Ettore Contessini] Univ Milan, Fac Med, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan
RP Avesani, EC (通讯作者)，Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Gen & Emergency Surg, Milan, Italy.
EM ettore.contessini@unimi.it
OI Corbellini, Carlo/0000-0003-0814-0537
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NR 25
TC 5
Z9 5
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD AUG 30
PY 2014
VL 9
AR 48
DI 10.1186/1749-7922-9-48
PG 5
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA AO6HT
UT WOS:000341451800001
PM 26085838
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kleif, J
   Fabricius, R
   Bertelsen, CA
   Bruun, J
   Gögenur, I
AF Kleif, Jakob
   Fabricius, Rasmus
   Bertelsen, Claus Anders
   Bruun, Jens
   Gogenur, Ismail
TI Promising results after vacuum-assisted wound closure and mesh-mediated
   fascial traction
SO DANISH MEDICAL JOURNAL
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; OPEN ABDOMEN; TRAUMA
AB INTRODUCTION: Patients with an open abdomen (OA) present a major challenge to the surgeon. High mortality and associated complication rates have been reported depending on the specific method of temporary abdominal closure, the primary disorder and any co-morbidity. Vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) is a novel technique recently introduced for late fascial closure of the OA. In previous studies, the disease aetiologies were mainly vascular and visceral surgical disease and trauma. We report our results using VAWCM in a non-trauma patient population treated with an OA due to visceral surgical disease.
   MATERIAL AND METHODS: Medical records of all patients in our department treated with VAWCM during the period from 1 August 2009 to 31 May 2011 were reviewed. All sixteen patients were non-trauma patients. The initial treatment was vacuum-assisted closure (VAC) (Abdominal Dressing System KCI, San Antonio, Texas, USA). VAWCM treatment was initiated if complete fascial closure could not be obtained with VAC.
   RESULTS: Two patients died of multiple organ failure that was not associated with the VAWCM treatment. In one patient, treatment was terminated due to a very short life expectancy. We achieved a complete fascial closure rate in seven out of 16 patients. One patient had a pancreatic fistula at discharge that was not associated with the VAWCM treatment. No enteric fistulas occurred.
   CONCLUSION: It seems that VAWCM can improve the rate of complete fascial closure after treatment with OA without increasing the mortality or the occurrence of enteric fistula compared with other kinds of temporary abdominal closure.
C1 [Kleif, Jakob; Fabricius, Rasmus; Bertelsen, Claus Anders; Bruun, Jens; Gogenur, Ismail] Cent Hosp Hillerod, Kirurg Afdeling, DK-3400 Hillerod, Denmark.
RP Kleif, J (通讯作者)，Cent Hosp Hillerod, Kirurg Afdeling, DK-3400 Hillerod, Denmark.
EM kleifen@dadlnet.dk
RI ; Bertelsen, Claus Anders/AAZ-8209-2020
OI Gögenur, Ismail/0000-0002-3753-268X; Bertelsen, Claus
   Anders/0000-0001-6337-8447; Kleif, Jakob/0000-0002-9330-0410
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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NR 19
TC 14
Z9 15
U1 0
U2 1
PU DANISH MEDICAL ASSOC
PI COPENHAGEN
PA TRONDHJEMSGADE 9, DK-2100 COPENHAGEN, DENMARK
EI 2245-1919
J9 DAN MED J
JI Dan. Med. J.
PD SEP
PY 2012
VL 59
IS 9
AR A4495
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 021LM
UT WOS:000309886300003
PM 22951196
DA 2026-07-24
ER

PT J
AU Sonmez, E
   Safak, T
AF Sonmez, Erhan
   Safak, Tunc
TI Reconstruction of the Soft Tissue Defects of Foot and Ankle with
   Neural-Island Flaps: Mono-Institutional Case Series
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE Neural-island flap; neurocutaneous flap; neuroskin flap;
   neuroadipofascial pedicled fasciocutaneous flap
ID SURAL FLAP; FASCIOCUTANEOUS FLAP; SAPHENOUS-VEIN; ARTERIES; DRAINAGE;
   FOREARM; NERVES; LEG
AB The aim of this report is to show the results obtained from using the neural-island flap to cover the soft tissue defects of the foot and ankle. This is the first report of the neural-island flap series since the introduction of this flap to the literature in 2003. Between 2002 and 2009 "neural-island flap'' was used to treat 20 patients of various lesions on the foot and ankle. All of the patients had serious soft tissue defects that compromised tendons, bones, or joints. In 16 patients, the tissue defects were completely and successfully covered with an uncomplicated postoperative course. In 4 patients the flaps presented venous congestion and intermittent bleeding and leech application was performed for 2 to 3 days postoperatively. Two of these flaps healed completely without any flap loss. In one patient because the partial flap necrosis occurred in distal one-fourth of the flap, skin grafting was performed after 1 week of vacuum-assisted closure application. Total flap necrosis occurred in only one patient who was suffering from Buerger disease. The authors conclude that the neural-island flap is a highly versatile, easy, and reproducible flap that avoids the use of complicated and risky reconstruction options. It can be considered as an alternative reconstruction option particularly in problematic cases that are not suitable for local or free tissue transfers.
C1 [Sonmez, Erhan] Hacettepe Univ Hastanesi, Hacettepe Univ Hosp, Dept Plast Surg, Plast & Rekonstruktif Cerrahi Anabilim Dali, TR-06100 Ankara, Turkey.
C3 Hacettepe University
RP Sonmez, E (通讯作者)，Hacettepe Univ Hastanesi, Hacettepe Univ Hosp, Dept Plast Surg, Plast & Rekonstruktif Cerrahi Anabilim Dali, TR-06100 Ankara, Turkey.
EM erhans@hacettepe.edu.tr
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NR 28
TC 5
Z9 5
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD SEP
PY 2011
VL 27
IS 7
BP 403
EP 408
DI 10.1055/s-0031-1281514
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 808ZG
UT WOS:000294019900003
PM 21717389
DA 2026-07-24
ER

PT J
AU Becker, HP
   Willms, A
   Schwab, R
AF Becker, Horst Peter
   Willms, A.
   Schwab, R.
TI Small bowel fistulas and the open abdomen
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Review
DE fistula; small bowel; open abdomen; damage control; laparostomy;
   vacuum-assisted closure
ID ABDOMINAL-WALL DEFECTS; FASCIAL CLOSURE; VENTRAL HERNIA; ENTEROCUTANEOUS
   FISTULAS; TEMPORARY CLOSURE; WOUND CLOSURE; MANAGEMENT; RECONSTRUCTION;
   EXPERIENCE; SEPARATION
AB Over the last 15 years, the contemporary strategies to treat the open abdomen have reduced the lethal complications. Systematic intensive care and modern wound management in conjunction with a plastic barrier to protect the viscera and topical negative pressure on the soft tissues have reduced the development of small bowel fistulas. The literature selected for this review shows that the surgical handling of the exposed bowel, the choice of the material for temporary coverage and early progressive closure of the defect are crucial for the prevention of fistulas. At present, surgeons worldwide have adopted these principles leading to an increase of primary or delayed closure rates. When a small fistula occurs, biological dressings like human acellular dermal matrix and fibrin glue may help to seal the orifice and to treat the patient conservatively. In case of a large fistula, vacuum-assisted wound management is recommended as well. Through a separate hole in the vacuum sponge matching to the fistula, the enteric contents are sucked off while the wound bed heals and is prepared for split thickness skin graft. Surgical resection of established fistula unresponsive to conservative measures should only be performed on patients well-nourished and free of infection with a delay of at least six months. For patients with an open abdomen, surgical expertise and a well-structured management plan offer the best chances to overcome this potentially devastating condition - with or without fistula.
C1 [Becker, Horst Peter; Willms, A.; Schwab, R.] Cent Mil Hosp, Dept Gen Abdominal & Thorac Surg, D-56072 Koblenz, Germany.
RP Becker, HP (通讯作者)，Cent Mil Hosp, Dept Gen Abdominal & Thorac Surg, Ruebenacher Str 170, D-56072 Koblenz, Germany.
EM horstpeter.becker@t-online.de
RI Willms, Arnulf/AFN-0812-2022
OI Willms, Arnulf/0000-0001-9998-6735
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NR 44
TC 80
Z9 95
U1 1
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2007
VL 96
IS 4
BP 263
EP 271
DI 10.1177/145749690709600402
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 243VM
UT WOS:000251825400002
PM 18265852
DA 2026-07-24
ER

PT J
AU Bui, UT
   Finlayson, K
   Edwards, H
AF Bui, Ut T.
   Finlayson, Kathleen
   Edwards, Helen
TI The diagnosis of infection in chronic leg ulcers: A narrative review on
   clinical practice
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE diagnosis; identification; indicator; infection; leg ulcer
ID RANDOMIZED CONTROLLED-TRIAL; ATMOSPHERIC ARGON PLASMA; VACUUM-ASSISTED
   CLOSURE; CHRONIC WOUNDS; MICROBIOLOGICAL ANALYSIS; MANAGEMENT; SILVER;
   SKIN; GEL; DRESSINGS
AB This literature review aimed to provide a narrative review of evidence on validity of clinical and microbial indicators of infection and to gain insights into the diagnosis of infection in chronic leg ulcers (CLUs). A search was conducted in Cinahl, Medline, the Cochrane Library databases, Embase, Web of Science, ScienceDirect, Pubmed, PsycINFO, ProQuest dissertations, and Google Scholar from January 1990 to July 2017. The inclusion criteria were original studies, systematic reviews, and consensus documents focused on "infection" in CLUs, English language, clinical and community settings, and human. The reviewed studies were inconsistent in criteria for infection between investigated wound types and lack of specificity regarding wound types. There were few studies investigating the criteria for diagnosis of infection in leg ulcers. The identification of leg ulcer infection still remains problematic and relies on out-of-date and not uniform evidence. Literature in this area was mostly limited to level III and IV evidence based on The Australian National Health and Medical Research Council Levels of Evidence, or expert opinion. This literature review showed seven clinical signs and symptoms that could be diagnostic for infection in CLUs, including: new, increased, or altered ulcer pain; malodour; increased ulcer area; wound breakdown, delayed or non-healing; and erythema and increased local temperature, whilst the microbial indicators used to diagnose infected leg ulcers were varied and regarded as less important.
C1 [Bui, Ut T.; Finlayson, Kathleen; Edwards, Helen] Queensland Univ Technol, Fac Hlth, Inst Hlth & Biomed Innovat, Sch Nursing, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
C3 Queensland University of Technology (QUT)
RP Bui, UT (通讯作者)，Queensland Univ Technol, Fac Hlth, Inst Hlth & Biomed Innovat, Sch Nursing, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
EM ut.bui@hdr.qut.edu.au
RI Edwards, Helen/GPX-3511-2022; Finlayson, Kathleen/D-1108-2012; Bui, Ut
   T/J-7766-2019
OI Bui, Ut T/0000-0001-5692-0138
FU PhD scholarship Funding Source: Medline
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NR 96
TC 20
Z9 22
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2019
VL 16
IS 3
BP 601
EP 620
DI 10.1111/iwj.13069
PG 20
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IF2PL
UT WOS:000472920000003
PM 30697930
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Tamhankar, AP
   Ravi, K
   Everitt, NJ
AF Tamhankar, A. P.
   Ravi, K.
   Everitt, N. J.
TI VACCUM ASSISTED CLOSURE® THERAPY IN THE TREATMENT OF MESH INFECTION
   AFTER HERNIA REPAIR
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Article
DE HERNIA; SURGICAL MESH; INFECTION; VACUUM-ASSISTED CLOSURE
ID PROSPECTIVE RANDOMIZED-TRIAL; WOUND THERAPY; INCISIONAL HERNIORRHAPHY;
   GROIN; SURGERY
AB Background: Mesh related infection after prosthetic abdominal wall hernia repair is a difficult clinical problem, particularly in an era of evolving microbial resistance. Commonly advocated treatment for such infection involves complete mesh excision which usually leaves a complicated weak wound. We report the use of VAC therapy for mesh infections that allows mesh preservation leaving a sound wound. Methods: From June 2002 to January 2007, four patients with mesh related infection after abdominal wall hernia repair were treated with VAC therapy. Patients' notes were reviewed to gather clinical details. Results: Mesh infection was evident after a variable period (day three to eight years) following hernia repair. Of the four patients, one had infection with methicillin resistant Staphylococcus aureus (MRSA), while the bacteriological cultures from two confirmed Staphylococcus aureus in one and a mixture of Pseudomonas and enterococcus species in the other. One patient failed to show significant bacterial growth on pus swab culture, having had prior broad-spectrum antibiotic treatment for mesh infection. Three patients had complete mesh preservation and one had partial mesh excision. All patients were treated with VAC therapy, following the drainage of their operation sites, until the visible mesh was covered with granulation (one to seven weeks). No patient had a recurrent hernia after complete wound healing. Conclusion: VAC therapy allows salvage of infected exposed mesh by promoting granulation through the mesh. judicious use of VAC therapy may prevent the need of mesh excision and its wound related complications.
C1 [Tamhankar, A. P.] Chesterfield Royal Hosp, Dept Surg, NHS Fdn Trust, Calow S44 5BL, Chesterfield, England.
RP Tamhankar, AP (通讯作者)，Chesterfield Royal Hosp, Dept Surg, NHS Fdn Trust, Calow S44 5BL, Chesterfield, England.
EM aptamhankar@hotmail.com
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NR 23
TC 13
Z9 16
U1 0
U2 6
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD OCT
PY 2009
VL 7
IS 5
BP 316
EP 318
DI 10.1016/S1479-666X(09)80010-3
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 511IL
UT WOS:000271157600010
PM 19848066
DA 2026-07-24
ER

PT J
AU Payne, JL
   Ambrosio, AM
AF Payne, Joanna L.
   Ambrosio, Archel M.
TI Evaluation of an Antimicrobial Silver Foam Dressing for Use With VAC®
   Therapy: Morphological, Mechanical, and Antimicrobial Properties
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE VAC therapy; silver; antimicrobial activity; morphology; wound healing
ID VACUUM-ASSISTED CLOSURE; NANOCRYSTALLINE SILVER
AB The V.A.C.(R) Therapy System (KCI, San Antonio, TX) is an integrated wound management system that creates an environment that promotes wound healing. V.A.C. GranuFoam Silver (R) dressing (S-ROCF) is a reticulated, open-celled polyurethane foam having a pore size range of 400-600 mu m. The foam is coated with silver to impart antimicrobial properties throughout the dressing. The morphological and key mechanical properties including tensile strength, ultimate elongation, tear strength, and compression resistance of this dressing were compared to the original V.A.C.(R)) GranuFoam( dressing (ROCF), Which is also a reticulated, open-celled polyurethane foam, and were found to be comparable. Furthermore, the antimicrobial property of S-ROCF was evaluated in vitro for efficacy against pathogens commonly found in clinical settings, including Staphylococcus aureus and Pseudomonas aeruginosa. S-ROCF was found to be effective during antimicrobial testing with a 99.99% reduction in colony forming units, and remained effective after 72 h of simulated V.A.C. Therapy. The antimicrobial and mechanical characteristics of the foam were unaffected by aging as demonstrated through an accelerated aging process. The V.A.C. GranuFoam Silver (R) dressing is a specialized antimicrobial dressing for use with the V.A.C. Therapy System that exhibits morphological and mechanical properties comparable to the V.A.C. GranuFoam dressing and provides the added benefit of antimicrobial efficacy. (C) 2008 Wiley, Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 89B: 217-222, 2009
C1 [Payne, Joanna L.; Ambrosio, Archel M.] Kinetic Concepts Inc, Global R&D, San Antonio, TX USA.
RP Ambrosio, AM (通讯作者)，Kinetic Concepts Inc, Global R&D, San Antonio, TX USA.
EM archel.ambrosio@kci1.com
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NR 12
TC 33
Z9 34
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD APR
PY 2009
VL 89B
IS 1
BP 217
EP 222
DI 10.1002/jbm.b.31209
PG 6
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 422XE
UT WOS:000264460200026
PM 19274724
DA 2026-07-24
ER

PT J
AU Wozniak, G
   Noll, T
AF Wozniak, G
   Noll, T
TI Mechanisms influencing cellular physiology as a concept of treatment for
   wound healing disturbances
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE endothelial barrier; permeability; growth factors; gene transfer; factor
   XIII
ID ENDOTHELIAL GROWTH-FACTOR; MYOCARDIAL GENE-TRANSFER; VACUUM-ASSISTED
   CLOSURE; PLASMA FACTOR-XIII; CROSS-LINKING; MATRIX METALLOPROTEINASES;
   THERAPEUTIC ANGIOGENESIS; BARRIER FUNCTION; BURN INJURY; PLATELET
AB Aim: Recent knowledge about repair mechanisms in different types of tissue is the basic of actual therapeutic efforts. Center of several experimental and clinical approaches is the influencing of angiogenesis with an also distinct meaning concerning wound healing. Therefore, application of growth factors, gene transfer, and employment of genetically manipulated cells often aim at angiogenesis. Nevertheless, manipulation of angiogenesis also leads to secondary problems such as hyperpermeability followed by impairment of local wound milieu. Our study was done to identify mechansims to protect from disturbances of endothelial barrier function. Method: In a first experimental investigation on cultured endothelial cells, the influence of plasma-transglutaminase (Factor XIII) to endothelial barrier function was studied. In a second step, the influence of Factor XIII on wound healing properties was investigated in patients with a chronic venous ulceration. Results: Activated Factor XIII (FXIIIA*) led to a dose-dependent reduction of endothelial cell permeability of 30% compared to control with a maximum effect using 1 to 5 U/mL. Clinical investigation revealed a nearly complete reduction of wound secretion. Conclusion: Experimental studies revealed that activated Factor XIII stabalizes endothelial barrier under basic conditions as well as under conditions of induced hyperpermeability. Clinical study revealed that Factor XIII also distinctly reduces wound secretion. Therefore, plasma-transglutaminase may offer a new therapeutic option to treat the local or generalized leakage-syndrome.
C1 Klin Gefasschirurg, Knappschaftskrankenhaus, Assoziiertem Wundfachzentrum, D-46242 Bottrop, Germany.
   Univ Giessen, Inst Physiol, Giessen, Germany.
C3 Justus Liebig University Giessen
RP Wozniak, G (通讯作者)，Klin Gefasschirurg, Knappschaftskrankenhaus, Assoziiertem Wundfachzentrum, Osterfelderstr 157, D-46242 Bottrop, Germany.
EM gernold.wozniak@kk-bottrop.de
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NR 49
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD DEC
PY 2005
VL 130
IS 6
BP 526
EP 533
DI 10.1055/s-2005-918203
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 998FU
UT WOS:000234304800004
PM 16382399
DA 2026-07-24
ER

PT J
AU Liu, TY
   Jiang, LL
   Li, JS
   Sun, J
   Li, HM
   Gao, JY
   Li, SS
   Li, J
   Zhao, HD
AF Liu, Taiyuan
   Jiang, Lili
   Li, Jiasi
   Sun, Jie
   Li, Haomeng
   Gao, Jiyue
   Li, Sushan
   Li, Jun
   Zhao, Haidong
TI A huge malignant phyllodes tumor of the breast with osteoclast-like
   giant cells: a case report
SO GLAND SURGERY
LA English
DT Article
DE Malignant phyllodes tumor (PT); osteoclast-like giant cell (OLGC);
   breast; mastectomy; case report
ID UNDIFFERENTIATED CARCINOMA
AB The malignant phyllodes tumor (PT) of the breasts is a rare type of fibroepithelial neoplasm. Osteoclast-like giant cells (OLGCs) exist in many types of tumors. But malignant PTs with OLGCs were rarely reported. Here, we presented a case of a 49-year-old woman who had a 23 cm x21 cm x6 cm mass which was growing for 2 years in her left breast. The patient had moderate anemia due to the hemorrhage and exudation on the surface of the tumor. The imaging examinations such as PET-CT found no lymphatic involvement and distant metastasis. We performed mastectomy with a 2 cm surgical margin and free skin flap transplantation to restore the big wound. The vacuum assisted closure (VAC) system was used to promote wound healing. Histological examination of the surgical specimen showed atypical spindle-like stroma cells, marked nuclear pleomorphism, focal necrosis, and mitotic activity. Typical leaf-like architectures of PTs were observed in some regions. OLGCs were found in many sections of the tumor with a number of vascular proliferations. The final diagnosis was malignant PT with OLGCs. After a three-month follow-up, no local recurrence or metastasis was found. Autogenous skin grafts with VAC are available for large area skin defect after excising a huge breast tumor. The presence of OLGCs in malignant tumors may be related to necrosis and hemorrhage of the tumor. These findings also provide opportunities for understanding the mechanisms of tumor formation and development.
C1 [Liu, Taiyuan; Jiang, Lili; Li, Jiasi; Sun, Jie; Li, Haomeng; Gao, Jiyue; Li, Jun; Zhao, Haidong] Dalian Med Univ, Affiliated Hosp 2, Dept Breast Surg, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
   [Li, Sushan] Dalian Med Univ, Affiliated Hosp 2, Dept Dermatol, Dalian, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Li, J; Zhao, HD (通讯作者)，Dalian Med Univ, Affiliated Hosp 2, Dept Breast Surg, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
EM dyeylj@hotmail.com; z.hddl@hotmail.com
RI Li, Jiasi/ODM-2065-2025; Jiang, Lili/IVV-5296-2023; Li,
   Haomeng/MXK-1990-2025
CR Chang HY, 2020, J CLIN PATHOL, V73, P51, DOI 10.1136/jclinpath-2019-206208
   Co M, 2018, J CLIN PATHOL, V71, P493, DOI 10.1136/jclinpath-2017-204827
   Cocjin HGB, 2019, J BONE JOINT SURG AM, V101, P1990, DOI 10.2106/JBJS.19.00125
   Dilani L, 2019, WHO CLASSIFICATION T
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   Gullett NP, 2009, BREAST J, V15, P41, DOI 10.1111/j.1524-4741.2008.00669.x
   Hamdy O, 2019, CHIRURGIA-BUCHAREST, V114, P512, DOI 10.21614/chirurgia.114.4.514
   Lu YW, 2019, ANN SURG ONCOL, V26, P1263, DOI 10.1245/s10434-018-07134-5
   Makar GS, 2020, CASE REP ONCOL MED, V2020, DOI 10.1155/2020/1989452
   Ofri A, 2020, BREAST J, V26, P1831, DOI 10.1111/tbj.13890
   Ohashi R, 2018, ANN DIAGN PATHOL, V33, P1, DOI 10.1016/j.anndiagpath.2017.11.003
   Ohashi R, 2018, PATHOL RES PRACT, V214, P253, DOI 10.1016/j.prp.2017.11.002
   Park JS, 2015, ARCH PLAST SURG-APS, V42, P288, DOI 10.5999/aps.2015.42.3.288
   Sah SK, 2015, INT J CLIN EXP PATHO, V8, P11785
   Wei J, 2014, CHIN J CANCER, V33, P492, DOI 10.5732/cjc.014.10048
   Xu ZH, 2019, THORAC CANCER, V10, P2054, DOI 10.1111/1759-7714.13190
   Zagelbaum NK, 2016, WORLD J SURG ONCOL, V14, DOI 10.1186/s12957-016-0982-6
   Zeng SY, 2015, MOL CLIN ONCOL, V3, P663, DOI 10.3892/mco.2015.503
   Zhang L, 2018, QUANT IMAG MED SURG, V8, P457, DOI 10.21037/qims.2018.05.05
NR 19
TC 5
Z9 6
U1 1
U2 11
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2227-684X
EI 2227-8575
J9 GLAND SURG
JI Gland Surg.
PD APR
PY 2021
VL 10
IS 4
BP 1508
EP 1514
DI 10.21037/gs-20-845
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA RT7WG
UT WOS:000644667600023
PM 33968702
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tilt, A
   Falola, RA
   Kumar, A
   Campbell, TJ
   Marks, JM
   Attinger, CE
   Evans, KK
AF Tilt, Alexandra
   Falola, Reuben A.
   Kumar, Anagha
   Campbell, Tessa J.
   Marks, Jacob M.
   Attinger, Christopher E.
   Evans, Karen K.
TI Operative Management of Abdominal Wound Dehiscence: Outcomes and Factors
   Influencing Time to Healing in Patients Undergoing Surgical Debridement
   With Primary Closure
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE abdominal wound; primary closure; dehiscence; surgery; debridement;
   pelvic wound; abdominopelvic; management
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS
AB Introduction. Plastic surgeons are often consulted by other surgical teams for management of wound dehiscence following abdominopelvic surgery. Objective. The purpose of this study is to determine whether operative debridement and primary closure of abdominopelvic wounds are safe and expeditious for patients. Materials and Methods. A retrospective analysis was conducted on a database of patients who underwent operative debridement and closure at a single institution between January 2011 and December 2015 for dehisced abdominal or pelvic wounds acquired from prior obstetric, gynecologic, transplant, plastic, or general surgery procedures. Results. Of the 163 patient records identified, 43 patients met inclusion criteria. The median time from final debridement and primary surgical closure to complete wound healing was 27 days. Time to healing differed significantly by index procedure type (P = .004), with obstetric procedures requiring the shortest median time (12.0 days) and general surgery procedures requiring the longest (39.5 days). Wound healing took 3.6 times longer for patients with diabetes (P = .046) and 11.4 times longer for patients who experienced delayed superficial wound healing or redehiscence (P = .003). Nevertheless, with the exception of 4 patients who died of other causes, all wounds (39/39; 100%) achieved complete wound closure. Conclusions. Operative debridement and closure of abdominopelvic wound dehiscence through a multidisciplinary team approach with plastic surgery results in expeditious wound healing with minimal complications, and it may be safer and more cost effective than healing by secondary intention.
C1 [Tilt, Alexandra; Falola, Reuben A.; Kumar, Anagha; Campbell, Tessa J.; Marks, Jacob M.; Attinger, Christopher E.; Evans, Karen K.] Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
C3 Georgetown University
RP Evans, KK (通讯作者)，Georgetown Univ Hosp, Dept Plast Surg, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM karen.kevans@medstar.net
OI Evans, Karen/0000-0003-1056-2114
CR Ahmed AS, 2016, J WOUND CARE, V25, pS35, DOI 10.12968/jowc.2016.25.Sup7.S35
   Broadbent E, 2012, CURR OPIN PSYCHIATR, V25, P135, DOI 10.1097/YCO.0b013e32834e1424
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   DODSON MK, 1992, OBSTET GYNECOL, V80, P321
   Endara M, 2013, PLAST RECONSTR SURG, V132, P996, DOI 10.1097/PRS.0b013e31829fe119
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   Kenig J, 2014, BMC SURG, V14, DOI 10.1186/1471-2482-14-65
   Mirzabeigi MN, 2015, PLAST RECONSTR SURG, V135, P14, DOI 10.1097/PRS.0000000000000805
   Pavlidis TE, 2001, EUR J SURG, V167, P351
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   van Ramshorst GH, 2013, J GASTROINTEST SURG, V17, P1477, DOI 10.1007/s11605-013-2233-2
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NR 19
TC 5
Z9 6
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2018
VL 30
IS 11
BP 317
EP 323
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV1VC
UT WOS:000484065900004
PM 30289765
DA 2026-07-24
ER

PT J
AU Perathoner, A
   Klaus, A
   Mühlmann, G
   Oberwalder, M
   Margreiter, R
   Kafka-Ritsch, R
AF Perathoner, Alexander
   Klaus, Alexander
   Muehlmann, Gilbert
   Oberwalder, Michael
   Margreiter, Raimund
   Kafka-Ritsch, Reinhold
TI Damage control with abdominal vacuum therapy (VAC) to manage perforated
   diverticulitis with advanced generalized peritonitis-a proof of concept
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Diverticulitis; VAC; Peritonitis; Colostomy
ID SIGMOID DIVERTICULITIS; HARTMANNS PROCEDURE; EMERGENCY-SURGERY; PRIMARY
   RESECTION; OPEN ABDOMEN; ANASTOMOSIS; CLOSURE; DISEASE; STRATEGIES;
   DIAGNOSIS
AB Perforated diverticulitis with advanced generalized peritonitis is a life-threatening condition requiring emergency operation. To reduce the rate of colostomy formation, a new treatment algorithm with damage control operation, lavage, limited closure of perforation, abdominal vacuum-assisted closure (VAC; V.A.C.A (R)), and second look to restore intestinal continuity was developed.
   This algorithm allowed for three surgical procedures: primary anastomosis +/- VAC in stable patients (group I), but damage control with lavage, limited resection of the diseased colonic segment, VAC and second-look operation with delayed anastomosis in patients with advanced peritonitis or septic shock (group II), and Hartmann procedure was done for social reasons in stable patients (group III)
   All 27 consecutive patients (16 women; median age 68 years) requiring emergency laparotomy for perforated diverticulitis (Hinchey III/IV) between October 2006 and September 2008 were prospectively enrolled in the study. No major complications were observed in group I (n = 6). Nine patients in group II (n = 15) had intestinal continuity restored during a second-look operation, of whom one patient developed anastomotic leakage. The median length of stay at intensive care unit was 5 days. Considering an overall mortality rate of 26% (n = 7), the rate of anastomosis in surviving patients was 70%.
   Damage control with lavage, limited bowel resection, VAC, and scheduled second-look operation represents a feasible strategy in patients with perforated diverticulitis (Hinchey III and IV) to enhance sepsis control and improve rate of anastomosis.
C1 [Perathoner, Alexander; Klaus, Alexander; Muehlmann, Gilbert; Oberwalder, Michael; Margreiter, Raimund; Kafka-Ritsch, Reinhold] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Kafka-Ritsch, R (通讯作者)，Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Anichstr 35, A-6020 Innsbruck, Austria.
EM reinhold.kafka-ritsch@uki.at
CR Ansari MZ, 2000, AUST NZ J SURG, V70, P6, DOI 10.1046/j.1440-1622.2000.01733.x
   Barker DE, 2000, J TRAUMA, V48, P201, DOI 10.1097/00005373-200002000-00001
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   Chapman J, 2005, ANN SURG, V242, P576, DOI 10.1097/01.sla.0000184843.89836.35
   Chautems RC, 2002, DIS COLON RECTUM, V45, P962, DOI 10.1007/s10350-004-6336-4
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   Cipolla J, 2005, AM SURGEON, V71, P202
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   Salem L, 2005, DIS COLON RECTUM, V48, P988, DOI 10.1007/s10350-004-0871-x
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   Schwesinger WH, 2000, ARCH SURG-CHICAGO, V135, P558, DOI 10.1001/archsurg.135.5.558
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   Taylor CJ, 2006, ANZ J SURG, V76, P962, DOI 10.1111/j.1445-2197.2006.03908.x
   Teixeira PGR, 2008, AM SURGEON, V74, P891
   Vermeulen J, 2007, DIGEST SURG, V24, P361, DOI 10.1159/000107719
NR 30
TC 66
Z9 70
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0179-1958
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JUN
PY 2010
VL 25
IS 6
BP 767
EP 774
DI 10.1007/s00384-010-0887-8
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 590QM
UT WOS:000277242100013
PM 20148255
DA 2026-07-24
ER

PT J
AU Spicka, P
   Chudácek, J
   Rezac, T
   Vomácková, K
   Ambroz, R
   Molnár, J
   Klos, D
   Vrba, R
AF Spicka, Petr
   Chudacek, Josef
   Rezac, Tomas
   Vomackova, Katherine
   Ambroz, Radek
   Molnar, Jan
   Klos, Dusan
   Vrba, Radek
TI Prognostic significance of comorbidities in patients with diffuse
   peritonitis
SO EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
LA English
DT Article
DE Peritonitis; Type of effusion; Comorbidity; Narrow presure wound
   therapy; Vacuum assisted closure
ID MORTALITY
AB Background Diffuse peritonitis is a severe disease with high mortality and morbidity rates. Therapy is fundamentally surgical. It is important to identify patients with a significantly worse prognosis and patients who may benefit from more aggressive surgical and postsurgical care such as NPWT (Narrow Pressure Wound Therapy) prior to surgery. We tried to identify a determining factor for higher morbidity and mortality rates resulting in a worse prognosis among initial data and patient comorbidities in order to focus therapy towards more aggressive surgical management. Methods In a group of 274 patients with diffuse peritonitis, we evaluated the type of peritonitis according to effusion, origin, surgery type, and the age, gender, and present comorbidities of the patients, and compared it with the overall mortality, morbidity rate, and duration of hospitalization. Results Patients without comorbidities had a significantly lower burden in both morbidity and mortality. We recorded the highest difference in mortality in patients with two or more comorbidities, with pulmonary and cardiovascular diseases, with malignancy and hypertension. Morbidity was found to be significantly exacerbated by the presence of two or more severe diseases, cardiovascular disease, malignancy, and hypertension. Conclusion We identified age, effusion type, and the presence of comorbidities as key factors for the prognosis of our patients-the morbidity and mortality rates were substantially increased in patients with two or more comorbidities, as well as by the presence of cardiovascular disease, malignancy, and hypertension. A more aggressive approach should be considered to improve the prognosis in these patients.
C1 [Spicka, Petr; Rezac, Tomas; Vomackova, Katherine; Ambroz, Radek; Molnar, Jan; Klos, Dusan; Vrba, Radek] Palacky Univ, Fac Med & Dent, Dept Surg, Hnevotinska 976-3, Olomouc 77515, Czech Republic.
   [Chudacek, Josef] Olomouc Univ Hosp, Dept Surg, IP Pavlova 185-6, Olomouc 77900, Czech Republic.
C3 Palacky University Olomouc; University Hospital Olomouc
RP Vrba, R (通讯作者)，Palacky Univ, Fac Med & Dent, Dept Surg, Hnevotinska 976-3, Olomouc 77515, Czech Republic.
EM radek.vrba@fnol.cz
RI ; Spicka, Petr/AAE-2392-2022; Vrba, Radek/AAE-3079-2022; Řezáč,
   Tomáš/AAX-4241-2021
OI Ambrož, Radek/0000-0002-5572-3148; Spicka, Petr/0000-0003-3166-2624; 
CR Anaya Daniel A, 2003, Surg Infect (Larchmt), V4, P355, DOI 10.1089/109629603322761418
   Berreta Julio, 2010, Acta Gastroenterol Latinoam, V40, P105
   Bleszynski MS, 2016, AM J SURG, V211, P926, DOI 10.1016/j.amjsurg.2016.01.012
   Clarke A, 2011, EUR J ANAESTH, V28, P16, DOI 10.1097/EJA.0b013e32833f5389
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   DHoore W, 1996, J CLIN EPIDEMIOL, V49, P1429, DOI 10.1016/S0895-4356(96)00271-5
   Montravers P, 2021, J ANTIMICROB CHEMOTH, V76, P3303, DOI 10.1093/jac/dkab307
   Nag DS, 2019, WORLD J CLIN CASES, V7, P2227, DOI 10.12998/wjcc.v7.i16.2227
   Saunders DI, 2012, BRIT J ANAESTH, V109, P368, DOI 10.1093/bja/aes165
   Schwarz A, 2007, EUR J MED RES, V12, P200
   Spicka P, 2022, LIFE-BASEL, V12, DOI 10.3390/life12040487
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   Tartaglia D, 2021, UPDATES SURG, V73, P1975, DOI 10.1007/s13304-021-01012-8
   Tolonen M, 2016, LANGENBECK ARCH SURG, V401, P611, DOI 10.1007/s00423-016-1454-8
   van Esch S, 2012, CONTRIB NEPHROL, V178, P264, DOI 10.1159/000337889
   WINKELTAU G, 1992, CHIRURG, V63, P1035
NR 16
TC 2
Z9 4
U1 0
U2 3
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1682-8631
EI 1682-4016
J9 EUR SURG
JI Eur. Surg.
PD DEC
PY 2022
VL 54
IS 6
BP 309
EP 316
DI 10.1007/s10353-022-00780-w
EA OCT 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6N4OH
UT WOS:000870663700001
OA hybrid
DA 2026-07-24
ER

PT J
AU Pan, A
   Cauda, R
   Concia, E
   Esposito, S
   Sganga, G
   Stefani, S
   Nicastri, E
   Lauria, FN
   Carosi, G
   Moroni, M
   Ippolito, G
AF Pan, Angelo
   Cauda, Roberto
   Concia, Ercole
   Esposito, Silvano
   Sganga, Gabriele
   Stefani, Stefania
   Nicastri, Emanuele
   Lauria, Francesco N.
   Carosi, Giampiero
   Moroni, Mauro
   Ippolito, Giuseppe
CA GISIG Working Grp Complicated Skin
TI Consensus document on controversial issues in the treatment of
   complicated skin and skin-structure infections
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Staphylococcus aureus; MRSA; Complicated skin and skin-structure
   infections; Topical negative therapy; Antibiotic therapy
ID SOFT-TISSUE INFECTIONS; RESISTANT-STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED
   CLOSURE; GRAM-POSITIVE BACTERIA; ONCE-WEEKLY DALBAVANCIN; DOUBLE-BLIND
   TRIAL; STANDARD THERAPY; POSTSTERNOTOMY MEDIASTINITIS;
   VANCOMYCIN-AZTREONAM; DEFINITIVE CLOSURE
AB Background: Complicated skin and skin-structure infections (cSSSI), including surgical site infections (SSI), cellulitis, and abscesses, have been extensively studied, but controversial issues still exist.
   Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for the following controversial issues: (1) What is the efficacy of topical negative pressure wound treatment as compared to standard of care in the treatment of severe surgical site infections, i.e., deep infections, caused by Gram-positive microorganisms? (2) Which are the most effective antibiotic therapies in the treatment of cSSSI, including SSI, due to methicillin-resistant staphylococci? Results are presented and discussed.
   Methods: A systematic literature search using the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and www.clinicaltrials.gov databases of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method was used for grading quality of evidence. An analysis of the studies published between 1990 and 2008 is presented and discussed in detail. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
C1 [Pan, Angelo] Ist Ospitalieri Cremona, Div Malattie Infett & Trop, Cremona, Italy.
   [Cauda, Roberto] Univ Cattolica Sacro Cuore, Ist Malattie Infett, Rome, Italy.
   [Concia, Ercole] Univ Verona, Dipartimento Malattie Infett, I-37100 Verona, Italy.
   [Esposito, Silvano] Univ Naples 2, Dipartimento Malattie Infett, Naples, Italy.
   [Sganga, Gabriele] Univ Cattolica Sacro Cuore, Ist Clin Chirurg, Rome, Italy.
   [Stefani, Stefania] Univ Catania, Dipartimento Microbiol, I-95124 Catania, Italy.
   [Nicastri, Emanuele; Lauria, Francesco N.; Ippolito, Giuseppe] Ist Nazl Malattie Infett Lazzaro Spallanzani, Rome, Italy.
   [Carosi, Giampiero] Univ Brescia, Ist Malattie Infett & Trop, Brescia, Italy.
   [Moroni, Mauro] Univ Milan, Ist Malattie Infett & Trop, Milan, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Verona; Universita della Campania Vanvitelli; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; University of
   Catania; IRCCS Lazzaro Spallanzani; University of Brescia; University of
   Milan
RP Pan, A (通讯作者)，Ist Ospitalieri Cremona, Div Malattie Infett & Trop, Cremona, Italy.
EM angelo.pan1@tin.it
RI ; STEFANI, STEFANIA/K-8075-2016; Ippolito, Giuseppe/J-7207-2017;
   nicastri, emanuele/K-7780-2016
OI CAUDA, Roberto/0000-0002-1498-4229; STEFANI,
   STEFANIA/0000-0003-1594-7427; Ippolito, Giuseppe/0000-0002-1076-2979;
   nicastri, emanuele/0000-0002-5606-8712
FU Pfizer; GISIG; GlaxoSmithKline; Gilead; Bristol Myers Squibb; Boehringer
   Ingelheim; Abbott; Merck Sharp Dohme; Novartis farma; Wyeth Lederle;
   Janssen
FX The GISIG Consensus Conference was organized with support from an
   unrestricted educational grant from Pfizer.For the present research, all
   members of the faculty of GISIG received a fee from the organizing
   secretariat of the GISIG Project.Conflict of interest for R. Cauda:
   GlaxoSmithKline, Gilead, Bristol Myers Squibb, Boehringer Ingelheim,
   Pfizer, Abbott, Merck Sharp & Dohme, Wyeth. Funding received from
   GlaxoSmithKline, Gilead, Bristol Myers Squibb, Boehringer Ingelheim,
   Pfizer, Abbott, Merck Sharp & Dohme. S. Esposito has received fees for
   speaking at national and international meetings and for consulting on
   Advisory boards from Pfizer, Novartis farma and Wyeth Lederle. G. Sganga
   has received honoraria for speaking for Pfizer. G. Ippolito and F.N.
   Lauria have received expert opinion fees from Pfizer. E. Nicastri has
   received paid expert opinion from MSD and Pfizer. A. Pan has received
   paid expert opinion fees from Janssen.
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NR 55
TC 17
Z9 19
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
EI 1878-3511
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD OCT
PY 2010
VL 14
SU 4
BP S39
EP S53
DI 10.1016/j.ijid.2010.05.007
PG 15
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 675OJ
UT WOS:000283839700007
PM 20851013
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yu, CM
   Yu, CM
   Yao, WT
   Chen, YF
   Lee, AL
   Liu, YC
   Tu, CP
   Huang, WC
   Tung, KY
   Tsai, MF
AF Yu, Chieh-Ming
   Yu, Chia-Meng
   Yao, Wen-Teng
   Chen, Yu-Fan
   Lee, An-Li
   Liu, Ying-Chun
   Tu, Chih-Peng
   Huang, Wen-Chen
   Tung, Kwang-Yi
   Tsai, Ming-Feng
TI Efficacy and safety of pectoralis muscle flap combined rectus abdominis
   muscle sheath fasciocutaneous flap for reconstruction of sternal
   infection
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE pectoralis myocutaneous flap; rectus abdominis fasciocutaneous flap;
   sternal closure; sternal reconstruction; sternal wound infection
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; RISK-FACTOR-ANALYSIS;
   CARDIAC-SURGERY; POSTSTERNOTOMY MEDIASTINITIS; MANAGEMENT;
   COMPLICATIONS; TRANSPOSITION; PREDICTORS; WALL
AB Few studies have assessed the efficacy and safety of reconstruction of sternal infection using a pectoralis muscle flap combined with a rectus abdominis muscle (RAM) sheath fasciocutaneous flap. We report here our experience with this procedure to reconstruct the sternal defect in patients (n = 46) with a deep sternal wound infection (DSWI) after cardiac surgery. After wound reconstruction, the proportion of prolonged mechanical ventilation use and intensive care unit (ICU) stay were 17.4% (n = 8) and 21.7% (n = 10), respectively. The 30-day all-cause mortality was 15.2%; recurrence rate was 17.4%; postoperative complications were 15.2%; and median hospital stay was 31 (0-157) days. Multivariate logistic regression analysis revealed that hypertension (beta = 21.32, 95%CI 4.955-37.68, P = .014), drainage-tube use (beta = 0.944, 95%CI 0.273-1.614, P = .008), and prolonged intensive care unit stay (beta = 53.65, 95%CI 31.353-75.938, P < .001) were significantly correlated with hospital stay. In conclusion, a procedure including surgical debridement, sternal reconstruction with bilateral PM and RAM sheath flap, long-term antibiotics, and adequate drainage is a beneficial technique in the reconstruction of deep sternal wound infection after cardiac surgery. Duration of drainage tube use may be as an index for a hospital stay or wound healing.
C1 [Yu, Chieh-Ming; Yu, Chia-Meng; Yao, Wen-Teng; Chen, Yu-Fan; Lee, An-Li; Liu, Ying-Chun; Tu, Chih-Peng; Huang, Wen-Chen; Tung, Kwang-Yi; Tsai, Ming-Feng] Mackay Mem Hosp, Dept Surg, Div Plast Surg, 92,Sec 2,Zhongshan N Rd, Taipei 10449, Taiwan.
   [Yu, Chieh-Ming; Yu, Chia-Meng; Yao, Wen-Teng; Chen, Yu-Fan; Lee, An-Li; Liu, Ying-Chun; Tu, Chih-Peng; Huang, Wen-Chen; Tung, Kwang-Yi; Tsai, Ming-Feng] MacKay Med Coll, Dept Med, New Taipei, Taiwan.
   [Yu, Chia-Meng; Yao, Wen-Teng; Liu, Ying-Chun; Tung, Kwang-Yi] Mackay Mem Hosp, Burn Ctr, Taipei, Taiwan.
   [Tsai, Ming-Feng] Taipei Med Univ, Grad Inst Biomed Informat, Coll Med Sci & Technol, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Medical University; Mackay Memorial
   Hospital; Taipei Medical University
RP Tsai, MF (通讯作者)，Mackay Mem Hosp, Dept Surg, Div Plast Surg, 92,Sec 2,Zhongshan N Rd, Taipei 10449, Taiwan.
EM vacaflower@gmail.com
OI Tsai, Ming-Feng/0000-0002-6185-6270; YU, CHIA-MENG/0000-0002-6971-7371
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NR 52
TC 4
Z9 7
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD NOV
PY 2022
VL 19
IS 7
BP 1829
EP 1837
DI 10.1111/iwj.13788
EA MAR 2022
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 5R7OR
UT WOS:000768819400001
PM 35289489
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Davis, BN
   Xu, HP
   Gottlieb, LJ
   Vrouwe, SQ
AF Davis, Brittany N.
   Xu, Hope
   Gottlieb, Lawrence J.
   Vrouwe, Sebastian Q.
TI Acute Burn Care
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PARTIAL THICKNESS BURNS; PLASTIC-SURGERY;
   BLOOD-LOSS; COST-EFFECTIVENESS; INHALATION INJURY; SKIN-GRAFTS;
   COMPARTMENT SYNDROME; SILVER SULFADIAZINE; PROSPECTIVE-TRIAL
AB Learning Objectives:After studying this article and viewing the videos, the participant should be able to: 1. Describe the current epidemiology of burn injuries. 2. Understand burn pathophysiology and perform a wound assessment. 3. Summarize the initial emergency management of a burn patient. 4. Calculate the anticipated fluid resuscitation requirements for a burn injury, and diagnose the complications of overresuscitation. 5. Describe the diagnosis and management of inhalation injury. 6. List the goals of wound care for superficial and deep burns, and describe the closed dressing technique. 7. Perform excision of a burn wound. 8. Compare various wound closure techniques using autografts and skin substitutes.Summary:Plastic surgeons are essential members of the multidisciplinary burn team. Burn injuries remain common, and plastic surgeons have an opportunity to develop and innovate the field of acute burn care in light of workforce shortages. Burn pathophysiology is complex and dynamic, which informs the challenges encountered during the perioperative phase. Accurate burn wound assessment remains difficult, with implications for diagnosis and management. A systematic approach is required when stabilizing a major burn and/or inhalation injury with newly updated fluid resuscitation and triage guidelines. Wound care continues to evolve, with an emphasis on a closed dressing technique. For deeper burns, new surgical techniques are emerging for surgical d & eacute;bridement, along with improvements to traditional methods of tangential excision. Following excision, a number of established and novel techniques are available to close the wound with either autografts or skin substitutes.
C1 [Davis, Brittany N.; Xu, Hope; Gottlieb, Lawrence J.; Vrouwe, Sebastian Q.] Univ Chicago, Sect Plast & Reconstruct Surg, 5841 South Maryland Ave,Room J641,MC 603, Chicago, IL 60637 USA.
C3 University of Chicago
RP Vrouwe, SQ (通讯作者)，Univ Chicago, Sect Plast & Reconstruct Surg, 5841 South Maryland Ave,Room J641,MC 603, Chicago, IL 60637 USA.
EM svrouwe@uchicago.edu
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NR 141
TC 20
Z9 23
U1 6
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2024
VL 153
IS 4
BP 804e
EP 823e
DI 10.1097/PRS.0000000000011182
PG 20
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA C4J6L
UT WOS:001289041800052
PM 38546365
DA 2026-07-24
ER

PT J
AU Grote, S
   Polzer, H
   Prall, WC
   Gill, S
   Shafizadeh, S
   Banerjee, M
   Bouillon, B
   Bäthis, H
AF Grote, S.
   Polzer, H.
   Prall, W. C.
   Gill, S.
   Shafizadeh, S.
   Banerjee, M.
   Bouillon, B.
   Baethis, H.
TI Prevention of infection in the current treatment of open fractures. An
   evidence-based systematic analysis
SO ORTHOPADE
LA German
DT Article
DE Open fractures; Evidence-based medicine; Antibiotics; Debridement;
   Vacuum treatment
ID VACUUM-ASSISTED CLOSURE; WOUND CLOSURE; ANTIBIOTIC-THERAPY; MANAGEMENT;
   CLASSIFICATION; DELAY; TIBIA; BONE; TIME; CIPROFLOXACIN
AB Treatment of open fractures remains an interdisciplinary challenge. Even success and evidence of infection prevention especially of new treatment options is not clear.
   A systematic search in available electronic databases over the years 1974 until 2011 was conducted. Only clinical analyses with more than 5 adult patients in the German, English or French languages were included. All studies were rated according to Centre for Evidence-Based Medicine (CEBM) criteria.
   Over 855 articles were found due to the search and after applying the exclusion and inclusion criteria 49 studies were finally assessed to contribute to the evidence-based recommendations.
   Grade A recommendation: early application of antibiotics against gram-positive organisms for all open fracture types, additional coverage of gram-negative organisms for type III open fractures. Early surgical debridement should be performed.
   Grade B recommendation: type III open fractures should be treated with antibiotics for a minimum of 72 h but not longer than 24 h after wound closure. Vacuum treatment is justified and beneficial if wound closure is not achieved.
   Grade C recommendation: additional local antibiotic treatment in combination with systematic antibiotics may be of benefit. Definitive wound closure should be achieved within 1 week.
   This evidence-based analysis shows that there is good evidence for the treatment of open fractures with antibiotics and surgical debridement. Vacuum treatment can be recommended if wound closure is not possible.
C1 [Grote, S.; Polzer, H.; Prall, W. C.; Gill, S.] Univ Munich, Chirurg Klin & Poliklin, D-80336 Munich, Germany.
   [Shafizadeh, S.; Banerjee, M.; Bouillon, B.; Baethis, H.] Univ Witten Herdecke, Klinikum Koln Merheim, Klin Orthopad Unfallchirurg & Sporttraumatol, Cologne, Germany.
C3 University of Munich; Witten Herdecke University
RP Grote, S (通讯作者)，Univ Munich, Chirurg Klin & Poliklin, Campus Innenstadt,Nussbaumstr 20, D-80336 Munich, Germany.
EM Stefan.Grote@med.uni-muenchen.de
RI Grote, Stefan/LKM-0665-2024; Polzer, Hans/Q-3864-2019
OI Polzer, Hans/0000-0002-6713-4017
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NR 68
TC 16
Z9 19
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0085-4530
EI 1433-0431
J9 ORTHOPADE
JI Orthopade
PD JAN
PY 2012
VL 41
IS 1
BP 32
EP 42
DI 10.1007/s00132-011-1839-x
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 881WP
UT WOS:000299522400007
PM 22273705
DA 2026-07-24
ER

PT J
AU Tamir, E
   Daniels, TR
   Finestone, A
   Nof, M
AF Tamir, Eran
   Daniels, Timothy R.
   Finestone, Aharon
   Nof, Matityalm
TI Off-loading of hindfoot and midfoot neuropathic ulcers using a
   fiberglass cast with a metal stirrup
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE hindfoot; midfoot; neuropathic ulcers; offloading
ID DIABETIC FOOT ULCERS; TOTAL CONTACT CASTS; PRESSURE
AB Background: This study was designed to assess the effectiveness of a method of off-loading large neuropathic ulcers of the hindfoot and midfoot. The device used is composed of a fiberglass cast with a metal stirrup and a window around the ulcer. Methods: A retrospective study of 14 diabetic and nondiabetic patients was performed. All had chronic plantar hindfoot or midfoot neuropathic ulcers that failed to heal with conventional treatment methods. A fiberglass total contact cast with a metal stirrup was applied. A window was made over the ulcer to allow daily ulcer care. Results: The average duration of ulcer before application of the metal stirrup was 26 + 13.2 (range 7 to 52) months. The ulcer completely healed in 12 of the 14 patients treated. The mean time for healing was 10.8 weeks for midfoot ulcers and 12.3 weeks for heel ulcers. Complications developed in four patients: three developed superficial wounds and one developed a full-thickness wound. In three of these four patients, local wound care was initiated, and the stirrup cast was continued to complete healing of the primary ulcer. Conclusions: A fiberglass cast with a metal stirrup is an effective off-loading device for midfoot and hindfoot ulcers. It is not removable and does not depend on patient compliance. The window around the ulcer allows for daily wound care, drainage of the ulcer and the use of vacuum-assisted closure (VAC) treatment. The complication rate is comparable to that of total contact casting.
C1 Univ Toronto, St Michaels Hosp, Toronto, ON M5C1R6, Canada.
   Univ Toronto, Toronto, ON, Canada.
   Assaf Harofeh Med Ctr, IL-70300 Zerifin, Israel.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; Tel Aviv University; Shamir Medical Center (Assaf Harofeh)
RP Daniels, TR (通讯作者)，Univ Toronto, St Michaels Hosp, 800-55 Queen St E, Toronto, ON M5C1R6, Canada.
EM danielst@smh.toronto.on.ca
RI Finestone, Aharon/R-9001-2019
OI Finestone, Aharon/0000-0003-1956-5557
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   UROSKIE T, FOOT ANKLE CLIN, V6, P801
NR 15
TC 16
Z9 17
U1 0
U2 2
PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC
PI SEATTLE
PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA
SN 1071-1007
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD OCT
PY 2007
VL 28
IS 10
BP 1048
EP 1052
DI 10.3113/FAI.2007.1048
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 219GG
UT WOS:000250072100004
PM 17923053
DA 2026-07-24
ER

PT J
AU Kopp, J
   Strnad, V
   Bach, AD
   Sauer, R
   Horch, RE
AF Kopp, J
   Strnad, V
   Bach, AD
   Sauer, R
   Horch, RE
TI Vacuum application increases therapeutic safety and allows intensified
   local radiation treatment of malignant soft-tissue tumors
SO STRAHLENTHERAPIE UND ONKOLOGIE
LA English
DT Article
DE brachytherapy; vacuum-assisted closure; tissue preconditioning; flap
   surgery
ID INTRAOPERATIVE RADIOTHERAPY; ASSISTED CLOSURE; BREAST-CANCER; WOUND
   CONTROL; BRACHYTHERAPY; SARCOMAS; BOOST; EXPERIENCE; CARCINOMA; IORT
AB Purpose: In order to simplify and improve outcome of radiation therapy and final defect coverage in patients suffering from invasive soft-tissue tumors, brachytherapy and application of V.A.C.uum-assisted closure (V.A.C.(R)) were combined with delaying flap incision. Patients and
   Methods: Two patients were excised as radically as possible and brachytherapy tubes were implanted directly on the tumor bed. At the same time, flaps for Later defect coverage were preconditioned by circumcision. Brachytherapy and external-beam irradiation were performed directly on the vacuum sponge followed by subsequent defect coverage with the preconditioned flaps.
   Results: Excision significantly reduced tumor masses in both patients; in one case sensible and motor function of the involved extremity was clearly improved. V.A.C.(R) coverage allowed repeated brachytherapy and external-beam applications following exact placing of plastic tubes and FLABs on the tumor bed. Sequential irradiation had no effect on neighboring flap tissues, which healed without impairment following transposition.
   Conclusion: Combination of V.A.C.(R) and brachytherapy can effectively replace circumstantial and Laborious IORT (intraoperative radiotherapy) procedures. Exact placement of tubes on the tumor bed without subsequent tissue coverage is conserving preconditioned flap tissues, which are transposed for final defect coverage at the end of radiotherapy. However, by circumventing radiation exposure of these tissues, a possible later irradiation sequence can be performed without endangering defect-covering flaps.
C1 Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, D-91054 Erlangen, Germany.
   Univ Erlangen Nurnberg, Med Ctr, Dept Radiat Therapy, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Erlangen Nurnberg, Med Ctr, Dept Plast & Hand Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM Raymund.Horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
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NR 26
TC 19
Z9 19
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0179-7158
EI 1439-099X
J9 STRAHLENTHER ONKOL
JI Strahlenther. Onkol.
PD FEB
PY 2005
VL 181
IS 2
BP 124
EP 130
DI 10.1007/s00066-005-1291-0
PG 7
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 908GQ
UT WOS:000227775900008
PM 15702301
DA 2026-07-24
ER

PT J
AU Wang, JW
   Zhao, XJ
AF Wang, Jingwei
   Zhao, Xiaojie
TI Early changes in immune-inflammatory indices and healing outcomes in
   pressure injuries patients: A retrospective study
SO EUROPEAN JOURNAL OF INFLAMMATION
LA English
DT Article
DE pressure injuries; neutrophil-to-lymphocyte ratio; systemic
   immune-inflammation index; wound healing; surgical flaps; biomarkers
ID NEUTROPHIL-LYMPHOCYTE RATIO; PROGNOSIS
AB Background: Early prediction of wound healing after flap reconstruction for stage IV pressure injuries remains challenging. This study evaluated the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) as predictors of healing outcomes. Methods: This retrospective cohort study included 127 patients with stage IV pressure injuries who underwent negative-pressure wound therapy and flap reconstruction between January 2020 and December 2024. Blood samples were collected at baseline, 72 hours, day 7, and day 14 post-surgery. The primary outcome was complete wound healing. Receiver operating characteristic curve analysis was used to assess the predictive performance of inflammatory indices. Results: Complete healing was achieved in 72 patients (56.7%) over a median follow-up of 18 weeks. The delayed/non-healing group had higher baseline NLR (9.2 vs 6.0, P<0.001) and SII (2068.3 vs 1351.2, P<0.001). Day 7 NLR reduction was greater in the healing group (-22.9% vs -10.6%, P<0.001). Baseline SII had the highest predictive value among individual markers (area under the curve [AUC] 0.774). Day 7 NLR change achieved AUC 0.784. The combined model incorporating baseline NLR and day 7 NLR change yielded an AUC of 0.838, with 81.9% sensitivity and 70.9% specificity. Time-dependent analysis showed consistent performance across 30-day, 60-day, and 90-day time points (AUC 0.798-0.838). Conclusions: Baseline SII and NLR, combined with early dynamic changes, may serve as potential predictors of healing after flap reconstruction for stage IV pressure injuries. Early assessment of NLR trajectory may provide adjunctive prognostic information, though prospective validation is required.
C1 [Wang, Jingwei] Xuzhou Med Univ, Affiliated Hosp, Dept Burn & Plast Surg, Xuzhou, Jiangsu, Peoples R China.
   [Zhao, Xiaojie] Xuzhou Med Univ, Affiliated Hosp, Dept Lab Med, 99 West Huaihai Rd, Xuzhou, Jiangsu, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University
RP Zhao, XJ (通讯作者)，Xuzhou Med Univ, Affiliated Hosp, Dept Lab Med, 99 West Huaihai Rd, Xuzhou, Jiangsu, Peoples R China.
EM zhaoxiaojiewater@163.com
FX The authors received no financial support for the research, authorship,
   and/or publication of this article.
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1721-727X
EI 2058-7392
J9 EUR J INFLAMM
JI Eur. J. Inflamm.
PY 2026
VL 24
AR 1721727X261463670
DI 10.1177/1721727X261463670
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KE8QL
UT WOS:001805287000001
OA gold
DA 2026-07-24
ER

PT J
AU Junak, M
   Gibson, A
AF Junak, Mary
   Gibson, Angela
TI Burn Progression in Human Skin-A Review of Current Knowledge and
   Opportunities for Future Research
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Review
DE burn progression; wound conversion; burn depth; indeterminate depth burn
ID TRANSIENT ISCHEMIC ATTACK; MAGNETIC-RESONANCE; WOUND PROGRESSION;
   IMAGING TECHNOLOGIES; APOPTOTIC DEATH; DEPTH; SECONDARY; INJURY; TISSUE;
   MODEL
AB Treatment of a burn wound often depends on the vertical depth of injury, which is commonly determined by visual assessment. Burn progression is the concept that in the early postburn period, a partial thickness burn may progress to a deeper burn requiring surgery. Therefore, the initial appearance of the wound may not be indicative of the eventual extent of injury. Several preclinical studies attribute burn wound progression to events such as vasoconstriction, inflammation, programmed cell death, free radical damage, and microvascular occlusion. Due to the concern for translatability of animal models for burn wounds, human studies are essential to understand burn progression in patients. Unfortunately, only a few small human studies exploring mechanisms, including apoptosis, ischemia, and infection exist. Inherent to determining burn progression is burn depth determination and healing potential, an area of research that has many ongoing investigations without a clear standard method to replace visual evaluation. Treatments to prevent burn progression in humans, including the use of negative pressure wound therapy and application of cooling dressings, have been studied with small sample sizes. Here, we aim to summarize the current data on human burn progression. Additionally, we discuss novel methods that could be used in future research to define early burn wound progression. Future work in human tissue should focus on the assessment and timeline of progression, explore the reversibility and prevention of injury progression, and use animal models in parallel as complementary tools for hypothesis-driven research based on findings in humans.
C1 [Junak, Mary; Gibson, Angela] Univ Wisconsin, Dept Surg, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Gibson, A (通讯作者)，Univ Wisconsin, Dept Surg, Madison, WI 53706 USA.
EM gibson@surgery.wisc.edu
RI ; Gibson, Angela/ABB-4367-2021
OI , Mary Junak/0009-0006-3761-3814; 
FU NIGMS NIH HHS [R01 GM145723] Funding Source: Medline
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NR 61
TC 3
Z9 3
U1 3
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JUL-AUG
PY 2025
VL 46
IS 4
BP 758
EP 767
DI 10.1093/jbcr/iraf014
EA MAY 2025
PG 10
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 6YY7X
UT WOS:001489716500001
PM 39957288
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Popescu, V
   Cauni, V
   Petrutescu, MS
   Rustin, MM
   Bocai, R
   Turculet, CR
   Doran, H
   Patrascu, T
   Lazar, AM
   Cretoiu, D
   Varlas, VN
   Mastalier, B
AF Popescu, Valentin
   Cauni, Victor
   Petrutescu, Marius Septimiu
   Rustin, Maria Madalina
   Bocai, Raluca
   Turculet, Cristina Rachila
   Doran, Horia
   Patrascu, Traian
   Lazar, Angela Madalina
   Cretoiu, Dragos
   Varlas, Valentin Nicolae
   Mastalier, Bogdan
TI Chronic Wound Management: From Gauze to Homologous Cellular Matrix
SO BIOMEDICINES
LA English
DT Review
DE chronic wounds; regenerative medicine; complex wounds
ID DIABETIC FOOT ULCER; VENOUS LEG ULCERS; CLASSIFICATION-SYSTEM;
   COMPRESSION THERAPY; BED PREPARATION; STEM-CELLS; DRESSINGS; HEALTH;
   CARE; INFECTIONS
AB Background: Chronic wounds are a significant health problem with devastating consequences for patients' physical, social, and mental health, increasing healthcare systems' costs. Their prolonged healing times, economic burden, diminished quality of life, increased infection risk, and impact on patients' mobility and functionality make them a major concern for healthcare professionals. Purpose: This review offers a multi-perspective analysis of the medical literature focusing on chronic wound management. Methods used: We evaluated 48 articles from the last 21 years registered in the MEDLINE and Global Health databases. The articles included in our study had a minimum of 20 citations, patients > 18 years old, and focused on chronic, complex, and hard-to-heal wounds. Extracted data were summarized into a narrative synthesis using the same health-related quality of life instrument. Results: We evaluated the efficacy of existing wound care therapies from classical methods to modern concepts, and wound care products to regenerative medicine that uses a patient's pluripotent stem cells and growth factors. Regenerative medicine and stem cell therapies, biologic dressings and scaffolds, negative pressure wound therapy (NPWT), electrical stimulation, topical growth factors and cytokines, hyperbaric oxygen therapy (HBOT), advanced wound dressings, artificial intelligence (AI), and digital wound management are all part of the new arsenal of wound healing. Conclusion: Periodic medical evaluation and proper use of modern wound care therapies, including the use of plasma-derived products [such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] combined with proper systemic support (adequate protein levels, blood sugar, vitamins involved in tissue regeneration, etc.) are the key to a faster wound healing, and, with the help of AI, can reach the fastest healing rate possible.
C1 [Popescu, Valentin; Petrutescu, Marius Septimiu; Lazar, Angela Madalina; Mastalier, Bogdan] Colentina Clin Hosp, Gen Surg Clin, Bucharest 020125, Romania.
   [Popescu, Valentin; Rustin, Maria Madalina; Bocai, Raluca; Turculet, Cristina Rachila; Doran, Horia; Patrascu, Traian; Lazar, Angela Madalina; Mastalier, Bogdan] Carol Davila Univ Med & Pharm, Gen Surg Dept, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Cauni, Victor] Colentina Clin Hosp, Urol Clin, Bucharest 020125, Romania.
   [Doran, Horia; Patrascu, Traian] Dr I Cantacuzino Clin Hosp, Prof I Juvara Gen Surg Clin, Bucharest 011437, Romania.
   [Cretoiu, Dragos] Alessandrescu Rusescu Natl Inst Mother & Child Hlt, Fetal Med Excellence Res Ctr, Bucharest 020395, Romania.
   [Cretoiu, Dragos] Carol Davila Univ Med & Pharm, Dept Genet, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.
   [Varlas, Valentin Nicolae] Filantropia Clin Hosp, Dept Obstet & Gynaecol, Bucharest 011171, Romania.
   [Varlas, Valentin Nicolae] Carol Davila Univ Med & Pharm, Dept Obstet & Gynaecol, 37 Dionisie Lupu St, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Cretoiu, D (通讯作者)，Alessandrescu Rusescu Natl Inst Mother & Child Hlt, Fetal Med Excellence Res Ctr, Bucharest 020395, Romania.; Cretoiu, D (通讯作者)，Carol Davila Univ Med & Pharm, Dept Genet, 8 Eroii Sanitari Blvd, Bucharest 050474, Romania.; Varlas, VN (通讯作者)，Filantropia Clin Hosp, Dept Obstet & Gynaecol, Bucharest 011171, Romania.; Varlas, VN (通讯作者)，Carol Davila Univ Med & Pharm, Dept Obstet & Gynaecol, 37 Dionisie Lupu St, Bucharest 020021, Romania.
EM popescu.vali.umf@gmail.com; victorcauni@yahoo.com;
   mariuspetrutescu@yahoo.co.uk; mariamadalinarustin@gmail.com;
   raluca.bocai@gmail.com; cristina_turculet22@yahoo.com;
   doranh2003@yahoo.com; patrascutraian@gmail.com;
   angelalazar.2008@yahoo.com; dragos@cretoiu.ro; valentin.varlas@umfcd.ro;
   bogdanmastalier@yahoo.com
RI Cretoiu, agos/G-3741-2011; /Z-5965-2019; Varlas, Valentin
   Nicolae/ABI-5875-2020; Popescu, Valentin/J-2905-2016; Lazar, Angela
   Madalina/AAL-2021-2021; DORAN, HORIA/N-9456-2013; Cretoiu,
   Dragos/G-3741-2011
OI Cretoiu, agos/0000-0003-3214-030X; Mastalier,
   Bogdan/0000-0003-3179-7350; Varlas, Valentin
   Nicolae/0000-0002-8342-9819; Popescu, Valentin/0000-0002-1317-4937;
   Lazar, Angela Madalina/0000-0002-3258-2311; 
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NR 77
TC 41
Z9 44
U1 5
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD SEP
PY 2023
VL 11
IS 9
AR 2457
DI 10.3390/biomedicines11092457
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA T7OY6
UT WOS:001079851800001
PM 37760898
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ge, XJ
   Sun, YT
   Lin, J
   Zhou, F
   Yao, G
   Luo, BL
   Su, X
AF Ge, Xiaojing
   Sun, Yute
   Lin, Jing
   Zhou, Fang
   Yao, Gang
   Luo, Binlin
   Su, Xin
TI Diagnostic Key Points and Surgical Management of Necrotizing Fasciitis:
   A Retrospective Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE necrotizing fasciitis; soft tissue infection; suppuration; gangrene;
   negative-pressure wound therapy
ID ULTRASONOGRAPHY; CLOSURE
AB Necrotizing fasciitis (NF) is a fatal disease with a high mortality rate that can be easily misdiagnosed. The aim of this study was to improve the diagnostic rate of NF and overall survival. We conducted a single-center, retrospective, noncontrolled study involving 36 patients who were admitted to our department between December 2017 and October 2019, and summarized the diagnostic key points and timing of surgical treatment. All patients were diagnosed at our department and underwent multiple courses of treatment. The records included information regarding underlying diseases, bacterial culture results, laboratory risk indicator for necrotizing fasciitis (LRINEC) score, number of procedures, and type of antibiotics. All 36 cases of NF were cured and showed good patient condition on follow-up; the mean number of surgeries was three, and the mean duration of hospitalization was 37 days (range, 21-83 days). The LRINEC scores of 16 patients were >= 8 points. Seventeen patients with underlying diabetic disease had higher inflammatory index scores than those without diabetes. The LRINEC scores of patients with (n = 17) and without (n = 19) DM were 7.40 +/- 2.99 and 3.80 +/- 2.39, respectively (P < .01). Cases of NF that were treated with early incision and surgical abscess drainage required fewer surgeries and a shorter length of hospitalization. Thus, surgeons should be more aware of NF and aim to make an early and accurate diagnosis using various approaches. Complete surgical debridement plays an essential role in NF treatment, and diabetes mellitus is a significant adverse factor that exacerbates the severity of NF. Negative-pressure techniques are useful in cases involving nonanaerobic infections and cause minimal complications.
C1 [Ge, Xiaojing; Sun, Yute; Lin, Jing; Zhou, Fang; Yao, Gang; Luo, Binlin; Su, Xin] Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China.
C3 Nanjing Medical University
RP Luo, BL; Su, X (通讯作者)，Nanjing Med Univ, Affiliated Hosp 1, Dept Plast & Burn Surg, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM luobin8212192340@sina.com; suxin@jsph.org.cn
OI Su, Xin/0000-0002-2117-9009; Sun, YuTe/0000-0002-2914-445X
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NR 35
TC 5
Z9 6
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2024
VL 23
IS 1
SI SI
BP 153
EP 160
AR 15347346211045282
DI 10.1177/15347346211045282
EA OCT 2021
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LM1U5
UT WOS:000705988900001
PM 34612747
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Murphy, JA
   Myers, D
   Trueman, P
   Searle, R
AF Murphy, J. A.
   Myers, D.
   Trueman, P.
   Searle, R.
TI Cost-effectiveness of single-use negative-pressure therapy compared with
   standard care for prevention of reconstruction failure in prepectoral
   breast reconstruction
SO BJS OPEN
LA English
DT Article
ID IMMEDIATE; METAANALYSIS
AB Background: Single-use negative-pressure wound therapy (sNPWT) has been reported to reduce the incidence of reconstruction failure in prepectoral breast reconstruction compared with standard surgical dressings. The aim of this economic evaluation was to investigate the cost-effectiveness of sNPWT compared with standard care for the prevention of reconstruction failure in prepectoral breast reconstruction in the UK.
   Method: A decision tree model was used to estimate the expected cost and effectiveness per patient. Effectiveness was measured both by the number of reconstruction failures avoided and the gain in quality-adjusted life-years (QALYs). The baseline incidence of reconstruction failure (8.6 per cent) was taken from a recently published study of 2655 mastectomies in the UK. The effectiveness of sNPWT used results from a clinical study comparing sNPWT with standard dressings. Previously published utility weights were applied. The cost of reconstruction failure was estimated from detailed resource data from patients with reconstruction failure, applying National Health Service reference costs. One-way, probabilistic, scenario and threshold analyses were conducted.
   Results: The undiscounted cost per patient associated with reconstruction failure was estimated to be 23 pound 628 (22 pound 431 discounted). The use of sNPWT was associated with an expected cost saving of 1706 pound per patient, an expected increase in QALYs of 0.0187 and an expected 0.0834 reconstruction failures avoided. Cost-effectiveness acceptability analysis demonstrated that, at a threshold of 20 pound 000 per QALY, 99.94 per cent of the simulations showed sNPWT to be more cost-effective than standard care.
   Conclusion: Among patients undergoing immediate prepectoral breast reconstruction, the use of sNPWT is more cost-effective than standard dressings.
C1 [Murphy, J. A.] Manchester Univ NHS Fdn Trusts, Nightingale Breast Unit, Manchester, Lancs, England.
   [Trueman, P.; Searle, R.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
C3 Smith & Nephew
RP Murphy, JA (通讯作者)，Wythenshawe Hosp, Nightingale Breast Unit, Southmoor Rd, Manchester M23 9LT, Lancs, England.
EM john.murphy@mft.nhs.uk
CR [Anonymous], Breast cancer incidence
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NR 26
TC 4
Z9 6
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2474-9842
J9 BJS OPEN
JI BJS Open
PD MAR
PY 2021
VL 5
IS 2
AR zraa042
DI 10.1093/bjsopen/zraa042
EA APR 2021
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SA6WK
UT WOS:000649442200025
PM 33839751
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lech, GE
   Neves, BH
   Oliveira, GT
   da Silveira, CAB
   Kasmirski, JA
   Lima, DL
   Cavazzola, LT
AF Lech, Gabriele Eckerdt
   Neves, Brian Henriques
   Oliveira, Gilson Tenorio
   da Silveira, Carlos Andre Balthazar
   Kasmirski, Julia Adriana
   Lima, Diego L.
   Cavazzola, Leandro Totti
TI Vacuum-assisted wound closure and mesh-mediated fascial traction for
   temporary closure in open abdomen: A single-arm meta-analysis
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
DE enteroatmospheric fistula; incisional hernia; negative pressure wound
   therapy; open abdomen
ID QUALITY-OF-LIFE; THERAPY; MANAGEMENT
AB IntroductionOpen abdomen (OA) therapy is used in the management of patients who require surgery for severe abdominal conditions. This meta-analysis aims to evaluate the VAWCM technique regarding short and long-term outcomes.MethodsPubMed, Embase, and Cochrane Central were systematically searched for studies that analyzed VAWCM therapy in OA. Primary outcomes were the complete fascial closure rate and mean duration of OA treatment. Statistical analyses were performed using R statistical software.ResultsSeven studies comprising 535 patients were included. We found a complete fascial closure rate of 77.3 per 100 patients (80.1%; 95% CI 59.6-88.7; I2 = 76%), with an overall mortality of 30.3 per 100 (33.5%; 95% CI 9.3-19.4; I2 = 78%). The pooled mean duration of OA treatment was 14.6 days (95% CI 10.7-18.6; I2 = 93%), while the mean length of hospital stay was 43.3 days (95% CI 21.2-65.3; I2 = 96%). As additional outcomes, we found an enteroatmospheric fistula rate of 5.6 per 100 patients (5.4%; 95% CI 2.3-13.3; I2 = 45%) and incisional hernia rate of 34.7 per 100 (34.6%; 95% CI 28.9-41.1; I2 = 0%). The subgroup analysis of mesh materials (polypropylene or polyglactin) showed a higher complete fascial closure rate for the polyglactin (89.1% vs. 66.6%; p = 0.02).ConclusionOur findings showed that VAWCM is a viable option for OA treatment, successfully reaching complete fascial closure, with a low duration of the technique, even though it presented a high heterogeneity between the studies.
C1 [Lech, Gabriele Eckerdt] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil.
   [Neves, Brian Henriques] Grande Rio Univ, Rio De Janeiro, Brazil.
   [Oliveira, Gilson Tenorio; da Silveira, Carlos Andre Balthazar] Bahiana Sch Med & Publ Hlth, Salvador, BA, Brazil.
   [Kasmirski, Julia Adriana] Univ Sao Paulo, Sao Paulo, Brazil.
   [Lima, Diego L.] Montefiore Med Ctr, The Bronx, NY USA.
   [Cavazzola, Leandro Totti] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Universidade do
   Grande Rio; Universidade de Sao Paulo; Montefiore Medical Center;
   Universidade Federal do Rio Grande do Sul
RP Lima, DL (通讯作者)，Montefiore Med Ctr, Dept Surg, New York, NY 10467 USA.
EM dilaurentino@gmail.com
RI Cavazzola, Leandro/G-1305-2015; L Lima, Diego/AAL-4497-2020; Kasmirski,
   Julia/KFB-2125-2024; Silveira, Carlos/PXC-4574-2026
OI Eckerdt Lech, Gabriele/0000-0002-4017-2945; L Lima,
   Diego/0000-0001-7383-1284; Kasmirski, Julia/0000-0002-7435-048X; 
CR Acosta S, 2017, EUR J VASC ENDOVASC, V54, P697, DOI 10.1016/j.ejvs.2017.09.002
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NR 30
TC 4
Z9 8
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD OCT
PY 2024
VL 48
IS 10
BP 2391
EP 2399
DI 10.1002/wjs.12336
EA SEP 2024
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J9P1X
UT WOS:001306657400001
PM 39243381
DA 2026-07-24
ER

PT J
AU Sheckter, CC
   Pridgen, B
   Li, A
   Curtin, C
   Momeni, A
AF Sheckter, Clifford C.
   Pridgen, Brian
   Li, Alexander
   Curtin, Catherine
   Momeni, Arash
TI Regional Variation and Trends in the Timing of Lower Extremity
   Reconstruction: A 10-Year Review of the Nationwide Inpatient Sample
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Review
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; MICROSURGICAL
   RECONSTRUCTION; ADMINISTRATIVE DATA; MANAGEMENT; SURGERY; TRAUMA;
   COVERAGE
AB Background: The ideal timing of soft-tissue coverage for open lower extremity fractures remains controversial. Using U.S. national data, this study aims to characterize secular trends and regional variation in the timing of soft-tissue coverage.
   Methods: Using discharge data from the Nationwide Inpatient Sample (2002 to 2011), the authors identified 888 encounters admitted from the emergency department with isolated open lower extremity fractures treated with pedicled or free tissue transfer. Soft-tissue coverage timing was assessed by patient factors, hospital characteristics, and fracture patterns. Statistical significance and secular trends were analyzed with generalized linear models.
   Results: The mean day of soft-tissue reconstruction was at 6.64 days. Over the 10-year period, the day of reconstruction increased significantly (from 6.12 days in 2002 to 12.50 days in 2011; coefficient, 0.09; 95 percent CI, 0.05 to 0.12; p < 0.001). Demographic and facility factors did not significantly impact timing. Elixhauser comorbidity scores greater than 2 were associated with later coverage (10.13 days versus 6.29 days; p = 0.001) along with multisite fractures (8.35 days; p = 0.022) and external fixators (8.78 days; p < 0.001). The U.S. Census division showed significant variation in timing ranging from 0.94 days (East North Central) to 9.84 days (Pacific).
   Conclusions: A progressive delay in the timing of soft-tissue reconstruction was noted and may be attributed to negative-pressure wound therapy. The timing of soft-tissue coverage varied by region after adjusting for patient and hospital factors. Additional studies are needed to understand the impact of delayed soft-tissue coverage on patient outcomes and health services utilization.
C1 Stanford Univ, Sch Med, Div Plast & Reconstruct Surg, Palo Alto, CA 94304 USA.
   Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA.
C3 Stanford University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System
RP Momeni, A (通讯作者)，Stanford Univ, Med Ctr, Div Plast & Reconstruct Surg, 770 Welch Rd,Suite 400, Palo Alto, CA 94304 USA.
EM amomeni@stanford.edu
RI Momeni, Arash/AAV-8300-2020
OI Momeni, Arash/0000-0002-6452-751X
CR Agency for Healthcare Research and Quality, HCUP DAT HEALTC COST
   [Anonymous], HCUP METH SER
   [Anonymous], 2010, Diffusion of Innovations
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NR 31
TC 7
Z9 9
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD NOV
PY 2018
VL 142
IS 5
BP 1337
EP 1347
DI 10.1097/PRS.0000000000004885
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GY1XO
UT WOS:000448330200080
PM 30511989
DA 2026-07-24
ER

PT J
AU Castro, FJC
   Eguía, AP
   Muñoz-Cruzado, VD
   Aguilar, LT
   González, JT
   Laga, I
   de Juan, FD
   Ciuro, FP
   Ruiz, JP
AF Castro, Francisco Jose Calero
   Eguia, Andres Padillo
   Munoz-Cruzado, Virginia Duran
   Aguilar, Luis Tallon
   Gonzalez, Jose Tinoco
   Laga, Iman
   de Juan, Fernando de la Portilla
   Ciuro, Felipe Pareja
   Ruiz, Javier Padillo
TI Personalized additive manufacturing of devices for the management of
   enteroatmospheric fistulas
SO BIOENGINEERING & TRANSLATIONAL MEDICINE
LA English
DT Article
DE 3D printing; computer-aided design; digestive system fistula;
   personalized medicine; wound care; wound healing
ID PRESSURE WOUND THERAPY; OPEN ABDOMEN; BIOCOMPATIBILITY; SCAFFOLDS
AB Additive manufacturing techniques allow the customized design of medical devices according to the patient's requirements. Enteroatmospheric fistula is a pathology that benefits from this personalization due to its extensive clinical variability since the size and morphology of the wound differ extensively among patients. Standard prosthetics do not achieve proper isolation of the wound, leading to a higher risk of infections. Currently, no effective personalized technique to isolate it has been described. In this work, we present the workflow for the design and manufacture of customized devices adapted to the fistula characteristics as it evolves and changes during the treatment with Negative Pressure Wound Therapy (NPWT). For each case, a device was designed with dimensions and morphology depending on each patient's requirements using white light scanning, CAD design, and additive manufacturing. The design and manufacture of the devices were performed in 230.50 min (184.00-304.75). After the placement of the device, the wound was successfully isolated from the intestinal content for 48-72 h. The therapy was applied for 27.71 & PLUSMN; 13.74 days, and the device was redesigned to adapt to the wound when geometrical evolutionary changes occur during the therapy. It was observed a decrease in weekly cures from 23.63 & PLUSMN; 10.54 to 2.69 & PLUSMN; 0.65 (p = 0.001). The fistulose size was reduced longitudinal and transversally by 3.25 & PLUSMN; 2.56 cm and 6.06 & PLUSMN; 3.14 cm, respectively. The wound depth also decreased by 1.94 & PLUSMN; 1.08 cm. In conclusion, customization through additive manufacturing is feasible and offers promising results in the generation of personalized devices for the treatment of enteroatmospheric fistula.
C1 [Castro, Francisco Jose Calero; Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; Laga, Iman; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Hosp Univ Virgen Rocio, Oncol Surg Cell Therapy & Organ Transplantat Grp, Inst Biomed Sevilla IBiS,CSIC, Seville, Spain.
   [Castro, Francisco Jose Calero; Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; Laga, Iman; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Hosp Univ Virgen Rocio, IBiS, Dept Gen Surg,CSIC, Seville, Spain.
   [Munoz-Cruzado, Virginia Duran; Aguilar, Luis Tallon; Gonzalez, Jose Tinoco; de Juan, Fernando de la Portilla; Ciuro, Felipe Pareja; Ruiz, Javier Padillo] Univ Seville, Seville, Spain.
   [Munoz-Cruzado, Virginia Duran; Ciuro, Felipe Pareja] Virgen Rocio Univ Hosp, Div Gen Surg, Av Manuel Siurot S-N, Seville 41013, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University
   Hospital; University of Sevilla; Virgen del Rocio University Hospital
RP Muñoz-Cruzado, VD; Ciuro, FP (通讯作者)，Virgen Rocio Univ Hosp, Div Gen Surg, Av Manuel Siurot S-N, Seville 41013, Spain.
EM virginia.dm.87@gmail.com; felipe.pareja67@gmail.com
RI ; Tallon-Aguilar, Luis/JHV-1215-2023; PAREJA CIURO,
   FELIPE/GZM-1224-2022; de la Portilla, Fernando/ABD-5393-2020; Durán
   Muñoz-Cruzado, Virginia/GYD-4982-2022
OI Laga Boul-Atarass, Imán/0000-0002-4496-3162; Tallon-Aguilar,
   Luis/0000-0002-7549-619X; Calero Castro, Francisco
   José/0000-0002-6039-3091; PAREJA CIURO, FELIPE/0000-0001-9192-3465; 
FU We would like to thank the personnel involved in the difficult care of
   these patients.
FX We would like to thank the personnel involved in the difficult care of
   these patients.
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NR 31
TC 2
Z9 2
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2380-6761
J9 BIOENG TRANSL MED
JI Bioeng. Transl. Med.
PD NOV
PY 2023
VL 8
IS 6
DI 10.1002/btm2.10583
EA SEP 2023
PG 12
WC Biotechnology & Applied Microbiology; Engineering, Biomedical;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Pharmacology &
   Pharmacy
GA CG6K6
UT WOS:001070770100001
PM 38023715
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Anghel, EL
   DeFazio, MV
   Barker, JC
   Janis, JE
   Attinger, CE
AF Anghel, Ersilia L.
   DeFazio, Michael V.
   Barker, Jenny C.
   Janis, Jeffrey E.
   Attinger, Christopher E.
TI Current Concepts in Debridement: Science and Strategies
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; PSEUDOMONAS-AERUGINOSA BIOFILM; DIABETIC FOOT
   ULCERS; IN-VITRO; ANTIBIOTIC-RESISTANCE; SURGICAL DEBRIDEMENT; BACTERIAL
   BIOFILMS; SENESCENT CELLS; INFECTIONS; MANAGEMENT
AB Background: The establishment of a healthy wound bed through adequate debridement of infected, senescent, and/or devitalized tissue is central to the progression of normal wound healing. Although a variety of surgical and nonsurgical strategies have been proposed, none have proven completely effective in all settings. This review focuses on the principles and techniques of modern debridement practices employed in the management of complex wounds.
   Methods: A comprehensive review of the PubMed/Medline and Ovid databases was performed to identify basic science and clinical studies using key words most relevant to biofilm, debridement, and wound healing. English language articles that were peer reviewed and that met the standard of evidence-based medicine were included. Level of evidence for various debridement approaches was rated utilizing the American Society of Plastic Surgeons Rating Levels of Evidence and Grading Recommendations.
   Results: The value of both operative and nonoperative debridement techniques, their indications, and limitations are described. With an emphasis placed on surgical debridement, this review highlights technical adjuncts that can be used to optimize wound bed preparation, including preoperative topical staining of the wound, as well as the use of color-guided endpoints to prevent removal of excess healthy tissue. The indications for using temporizing measures for wound control such as negative pressure wound therapy with and without installation are also discussed.
   Conclusion: Optimal management requires a multimodal approach that centers around operative debridement and incorporates the use of adjunctive measures to facilitate the removal of infected tissue, biofilm, and/or senescent cells that impede the progression of normal wound healing.
C1 MedStar Georgetown Univ Hosp, Dept Plast Surg, Washington, DC USA.
   Ohio State Univ, Med Ctr, Dept Plast Surg, Columbus, OH 43210 USA.
C3 Georgetown University; University System of Ohio; Ohio State University
RP Janis, JE (通讯作者)，Ohio State Univ, Wexner Med Ctr, Univ Hosp, Dept Plast Surg, 915 Olentangy River Rd,Suite 2100,Room 2114, Columbus, OH 43212 USA.
EM Jeffrey.Janis@osumc.edu
RI Barker, Jenny/KYR-0129-2024; Janis, Jeffrey/W-6760-2019
OI Barker, Jenny/0000-0002-1517-5124; Janis, Jeffrey/0000-0001-6103-4798
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NR 79
TC 58
Z9 71
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 82S
EP 93S
DI 10.1097/PRS.0000000000002651
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300011
PM 27556779
DA 2026-07-24
ER

PT J
AU Dawson, VJ
   Echalier, EL
   Vu, B
   Liao, S
   Goddard, J
   Hink, E
AF Dawson, Valerie J.
   Echalier, E. Lacey
   Vu, Brian
   Liao, Sophie
   Goddard, Julie
   Hink, Eric
TI Severe Diesel Injection Injury to the Face, Neck and Orbit: Surgical
   Management and Critical Care Considerations
SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID PRESSURE WOUND THERAPY; GREASE-GUN INJURY
AB The purpose of this report is to discuss high-pressure injection injuries involving the face and orbit and discuss factors affecting prognosis and management as these injuries are rare and uniquely challenging to manage given the complex anatomy and extensive damage that may occur. In this case, we present severe injury to the left orbit, maxillofacial region, and neck of a 29-year-old male who suffered a high-pressure diesel injection injury requiring several surgical debridements, intensive care unit (ICU) level care, and ultimately sub-total exenteration. Initial management involved systemic antibiotics, steroids, and surgical debridement; however, our patient experienced subsequent rapid deterioration resulting in admission for more aggressive subspecialty intervention. Decision-making was guided by serial CT of the face and orbits, and C-reactive protein (CRP) levels in addition to the physical examination. His course was complicated by progressive extensive soft tissue necrosis requiring 8 surgical debridements and optic nerve tenting despite orbital decompression resulting in loss of the OS. Ultimately, definitive treatment required sub-total exenteration and negative wound pressure therapy over the orbit followed by eyelid reconstruction as an outpatient. We conclude that without prompt recognition and meticulous debridement, the resultant injury from high-pressure injection injuries can be devastating and lead to permanent vision loss, loss of an eye, loss of facial function, and airway compromise depending on the location of the injury. A multi-disciplinary team involving oculoplastics, otolaryngology, infectious disease, and ICU should be assembled based on the complexity of this injury and its sequela. CRP can be useful to monitor patient recovery and the need for further surgical intervention. When debridement results in complex wounds over the orbit and face, negative pressure wound therapy should be considered.
C1 [Dawson, Valerie J.; Vu, Brian; Liao, Sophie; Hink, Eric] Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO 80045 USA.
   [Echalier, E. Lacey] Med Eye Ctr Medford Oregon, Medford, OR USA.
   [Goddard, Julie] Univ Colorado, Dept Otolaryngol, Sch Med, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz;
   University of Colorado System; University of Colorado Anschutz
RP Dawson, VJ (通讯作者)，Univ Colorado, Dept Ophthalmol, Sch Med, Aurora, CO 80045 USA.
CR Bae Kyoung Hwa, 2018, Korean J Ophthalmol, V32, P158, DOI [10.3341/kjo.2017.0135, 10.3341/kjo.2017.0135]
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   Clark S., DIESEL FUEL INJECTIO
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NR 13
TC 2
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0740-9303
EI 1537-2677
J9 OPHTHAL PLAST RECONS
JI Ophthalmic Plast. Reconstr. Surg.
PD NOV-DEC
PY 2022
VL 38
IS 6
BP E173
EP E176
DI 10.1097/IOP.0000000000002230
PG 4
WC Ophthalmology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology; Surgery
GA 5X0FC
UT WOS:000878281900005
PM 35604381
DA 2026-07-24
ER

PT J
AU Akashi, Y
   Ogawa, K
   Sasaki, K
   Kim, J
   Enomoto, T
   Hisakura, K
   Ohara, Y
   Owada, Y
   Takahashi, K
   Shimomura, O
   Hashimoto, S
   Sekido, M
   Oda, T
AF Akashi, Yoshimasa
   Ogawa, Koichi
   Sasaki, Kaoru
   Kim, Jaejeong
   Enomoto, Tsuyoshi
   Hisakura, Katsuji
   Ohara, Yusuke
   Owada, Yohei
   Takahashi, Kazuhiro
   Shimomura, Osamu
   Hashimoto, Shinji
   Sekido, Mitsuru
   Oda, Tatsuya
TI Delayed primary fascia closure of Bjorck grade 4 open abdomen with
   enteroatmospheric fistulas after repeated surgery for adhesive small
   bowel obstruction: a case report
SO BMC SURGERY
LA English
DT Article
DE Open abdomen; Enteroatmospheric fistula; Bjorck classification; Small
   bowel obstruction; Case report
ID OPERATIVE MANAGEMENT
AB Background An open abdomen with frozen adherent bowels is classified as grade 4 in Bjorck's open abdomen classification, and skin grafting after wound granulation is a typical closure option. We achieved delayed primary fascia closure for a patient who developed open abdomen with enteroatmospheric fistulas due to severe adherent small bowel obstruction. We present here the details of his management. Case presentation A 52-year-old man suffered acute abdominal pain during a flight and received an emergency laparotomy due to adhesive small bowel obstruction. Repeated laparotomies were required, and later open abdomen and proximal site jejunostomy were selected. After negative pressure wound therapy, he was transferred to our institution. Two enteroatmospheric fistulas emerged on the exposed intestine, and we diagnosed the condition as a Bjorck grade 4 open abdomen. After 8 months of wound care and parenteral nutrition, we decided to attempt primary wound closure because the patient required permanent oral restriction and total parenteral nutrition due to short bowel syndrome. A circular incision along the circumference of the exposed bowel allowed us to take a safe approach into the abdominal cavity. We removed the intestinal adhesions completely and resected the bowels, including the fistulas and anastomosed parts. Finally, the abdominal wall defect was reconstructed using the component separation technique, and the patient was discharged without an ostomy. Conclusions Primary fascia closure for grade 4 open abdomen is hard, but leaving a long interval before radical surgery and applying pertinent wound management may help solve this adverse situation.
C1 [Akashi, Yoshimasa; Ogawa, Koichi; Kim, Jaejeong; Enomoto, Tsuyoshi; Hisakura, Katsuji; Ohara, Yusuke; Owada, Yohei; Takahashi, Kazuhiro; Shimomura, Osamu; Hashimoto, Shinji; Oda, Tatsuya] Univ Tsukuba, Fac Med, Dept Gastrointestinal & Hepatobiliary Pancreat Su, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
   [Sasaki, Kaoru; Sekido, Mitsuru] Univ Tsukuba, Fac Med, Dept Plast Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
C3 University of Tsukuba; University of Tsukuba
RP Akashi, Y (通讯作者)，Univ Tsukuba, Fac Med, Dept Gastrointestinal & Hepatobiliary Pancreat Su, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM yakashi@md.tsukuba.ac.jp
RI Akashi, Yoshimasa/PJB-9440-2026
OI Akashi, Yoshimasa/0000-0003-0589-3816
CR Björck M, 2009, WORLD J SURG, V33, P1154, DOI 10.1007/s00268-009-9996-3
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Egin S., 2018, TURK J TRAUMA EMERG, V25, P80
   Sriussadaporn S, 2006, ASIAN J SURG, V29, P1, DOI 10.1016/S1015-9584(09)60284-0
   Yetisir F, 2017, HERNIA, V21, P809, DOI 10.1007/s10029-017-1614-y
   Yetisir F, 2017, INDIAN J SURG, V79, P173, DOI 10.1007/s12262-017-1595-1
   Yetisir F, 2017, INDIAN J SURG, V79, P38, DOI 10.1007/s12262-015-1422-5
NR 8
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD AUG 26
PY 2021
VL 21
IS 1
AR 333
DI 10.1186/s12893-021-01329-6
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UI9GE
UT WOS:000690905100001
PM 34452624
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Granger, S
   Fallon, J
   Hopkins, J
   Pullyblank, A
AF Granger, S.
   Fallon, J.
   Hopkins, J.
   Pullyblank, A.
TI An open and closed case: timing of closure following laparostomy
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Article
DE Laparostomy; Open abdomen; Negative pressure wound therapy; Closure;
   Timing
ID PRIMARY FASCIAL CLOSURE; OPEN ABDOMEN; TRAUMA PATIENTS; MANAGEMENT;
   OUTCOMES; HERNIA
AB INTRODUCTION Laparostomy is important in the management of patients with intra-abdominal gastrointestinal catastrophe or trauma. It carries significant risk and is resource intensive, both in terms of nursing and surgically. The main goal is to achieve prompt myofascial closure (MFC) in order to minimise morbidity and mortality. Early MFC was initially defined as within 2-3 weeks but there is growing evidence that this should be measured in days.
   METHODS Retrospective analysis was undertaken of laparostomy cases between 2016 and 2018 at an acute trust and trauma centre serving a population of 500,000. Indication, duration of open abdomen (OA), number of relook procedures and consultant presence were examined to see whether they affected MFC rates, morbidity and mortality.
   RESULTS Overall, 76 laparostomies were performed during the 3-year study period. The most common indication was peritonitis (68.4%). As duration of OA and number of relook procedures increased, the chances of MFC fell significantly. After day 1, MFC rates fell by 20% with each subsequent 24 hours. Leaving the abdomen open primarily at index procedure compared with performing laparostomy following a postoperative complication was associated with significantly higher MFC rates (92.6% vs 68.2%, (p=0.006). The mortality rate was 15.8%.
   CONCLUSIONS If the OA is not closed within five days or by the third relook procedure, then achieving MFC is unlikely. Alternative methods should be employed to close the abdomen rather than continuing to take the patient back to theatre for relook laparotomies while increasing the risk of morbidity and mortality. A proactive strategy to forming primary laparostomy at the index procedure has high closure rates.
C1 [Granger, S.; Fallon, J.; Hopkins, J.; Pullyblank, A.] North Bristol NHS Trust, Bristol, Avon, England.
C3 North Bristol NHS Trust
RP Granger, S (通讯作者)，North Bristol NHS Trust, Bristol, Avon, England.
EM s.granger@nhs.net
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   National Emergency Laparotomy Audit, NAT EM LAP AUD
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   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
NR 29
TC 13
Z9 17
U1 0
U2 1
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD SEP
PY 2020
VL 102
IS 7
BP 519
EP 524
DI 10.1308/rcsann.2020.0105
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NH9OI
UT WOS:000564990100019
PM 32538103
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kapukaya, R
   Ciloglu, O
AF Kapukaya, Rana
   Ciloglu, Osman
TI Treatment of chronic wounds with polyurethane sponges impregnated with
   boric acid particles: A randomised controlled trial
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE boric acid particle; chronic wound; negative pressure wound therapy
ID SILVER; BORON
AB The objective of this study was to investigate the effectiveness of the sponge with boric acid particles combined with the negative pressure wound treatment (NPWT) system for chronic wounds with tissue defects. Our study was designed as a prospective randomised study. One hundred patients who were planned to have NPWT due to chronic wounds were included in this study from Orthopaedics and Traumatology and Plastic Surgery clinics. Patients were divided into two groups. In the first group, a new method, boric acid impregnated sponge, combined with the NPWT system, was used, and in the second group, sponge with silver nitrate was used. Besides the wide-broad spectrum antibacterial properties of silver nitrate, the antimicrobial, angiogenetic, and epithelial effects of boric acid were aimed to investigate by macroscopically and histopathologically. Thirty-six patients in the silver nitrate group and 44 patients in the boric acid group completed the study. A decrease in wound size and granulation was observed in both groups. Macroscopically, a decrease in wound size reduction, epithelialization and granulation were more prominent in the first group in which boric acid impregnated sponge was used than the second group in which silver sponge was used. Moreover, microscopically, the number of fibroblasts, collagen synthesis, and angiogenesis were significantly increased in Group 1. In this clinical study, the broad-spectrum antimicrobial properties of boric acid and its positive effect on the cells responsible for wound healing were found to be more pronounced compared to silver nitrate sponges. A combination of boric acid sponges with the NPWT system may be an alternative method for chronic wounds.
C1 [Kapukaya, Rana] Univ Hlth Sci, Dept Plast & Reconstruct Surg, Adana City Res & Training Hosp, Mithat Ozhan Bulvari Kula Mah 1 Yuregir, Adana, Turkey.
   [Ciloglu, Osman] Univ Hlth Sci, Dept Orthopaed & Traumatol, Adana City Res & Training Hosp, Adana, Turkey.
C3 University of Health Sciences Turkey; University of Health Sciences
   Turkey
RP Ciloglu, O (通讯作者)，Univ Hlth Sci, Dept Plast & Reconstruct Surg, Adana City Res & Training Hosp, Mithat Ozhan Bulvari Kula Mah 1 Yuregir, Adana, Turkey.
EM osmanciloglu@gmail.com
RI KAPUKAYA, RANA/HKE-5389-2023; ciloglu, osman/QKY-0989-2026
OI KAPUKAYA, RANA/0000-0001-9709-328X; Ciloglu, Osman/0000-0002-3660-3511; 
CR AE G, 2019, HARRAN U TP FAKULTES, V16, P148
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NR 22
TC 18
Z9 24
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2020
VL 17
IS 5
BP 1159
EP 1165
DI 10.1111/iwj.13463
EA JUL 2020
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA NP6YE
UT WOS:000548143200001
PM 32662209
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kilpadi, DV
   Olivie, M
AF Kilpadi, Deepak, V
   Olivie, Mariana
TI Evaluation of closed incision negative pressure therapy systems on the
   closure of incisional space model
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure therapy (ciNPT); foam-based ciNPT
   dressings; non-foam-based ciNPT dressings; simulated tissue model;
   negative pressure wound therapy (NPWT)
ID SURGICAL-SITE INFECTIONS; WOUND THERAPY; FINANCIAL IMPACT; MANAGEMENT;
   COMPLICATIONS
AB Objective: The objective of this study was to compare the ability of foam dressing-based and non-foam-based closed incision negative pressure therapy (ciNPT) systems to close isolated incisional deficits in a tissue model.
   Methods: Similarly sized foam-based and non-foam-based absorbent ciNPT dressings were applied to similar to 36cm long, similar to 3mm and similar to 6mm wide simulated incisions in gel sheets covered with drape (n=6 dressings/group/experimental condition spread over three respective therapy units). Changes in incision widths were measured directly or with overlying solid gel sheeting (to mimic tissue resistance), at five equally spaced locations before, immediately upon and one hour after initiating negative pressure using associated therapy units.
   Results: Foam-based ciNPT closed simulated incisions more often than non-foam-based ciNPT in all tested conditions (p<0.05). While foam-based ciNPT almost completely closed the similar to 3mm wide incisional spaces, unlike non-foam-based ciNPT, the biggest differences between the two groups were observed with the similar to 6mm incisional width, which allowed maximal inward-stretching of the appositional faces without complete closure. The additional gel layer blunted closure in both groups, but much more with non-foam-based ciNPT. There was minimal impact of negative pressure duration on these results.
   Conclusion: Foam-based ciNPT closed incisional widths in simulated tissue significantly more compared with non-foam-based ciNPT. Different ciNPT systems should not be considered necessarily equivalent in performance.
C1 [Kilpadi, Deepak, V; Olivie, Mariana] 3M KCI, San Antonio, TX 78249 USA.
RP Kilpadi, DV (通讯作者)，3M KCI, San Antonio, TX 78249 USA.
EM deepak.kilpadi@acelity.com
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NR 34
TC 2
Z9 2
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD DEC
PY 2019
VL 28
IS 12
BP 850
EP 860
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JU2TE
UT WOS:000501528100012
PM 31825775
DA 2026-07-24
ER

PT J
AU Molan, P
   Rhodes, T
AF Molan, Peter
   Rhodes, Tanya
TI Honey: A Biologic Wound Dressing
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE biology of wound healing; components of wound healing; honey; wound
   dressing
ID INDUCED GASTRIC-LESIONS; MANUKA HONEY; NATURAL HONEY; IN-VITRO;
   ANTIBACTERIAL ACTIVITY; TOPICAL APPLICATION; FOURNIERS GANGRENE;
   NITRIC-OXIDE; LEG ULCER; INFLAMMATION
AB Honey has been used: as a mound dressing for thousands of years, but Only in more recent times has a scientific explanation become available for its effectiveness. It is now:realized that honey is a biologic wound dressing with multiple bioactivities that work in concert to expedite the healing process. The physical properties of honey also expedite the healing process: its acidity increases the release of oxygen from hemoglobin thereby making the wound environment less favorable for the activity of destructive proteases, and the high osmolarity of honey draws fluid out of the wound, bed to create an outflow of lymph as occurs with negative pressure wound therapy. Honey has a broad-Spectrum antibacterial activity, but there is much variation in potency between different honeys. There are 2 types of antibacterial activity. In Most honeys the activity is due to hydrogen peroxide, but much of this is inactivated by the enzyme Catalase that is present in blood, serum, and wound tissues. In manuka honey, the activity is due to methylglyoxal which is not inactivated. The manuka honey Used in wound-care products can withstand dilution with substantial amounts of wound exudate and still maintain enough activity to inhibit the growth of bacteria. There is good evidence for honey also having bioactivities that Stimulate the immune response (thus promoting the growth of tissues for wound repair), suppress inflammation, and bring about rapid autolytic debridement. There is clinical evidence for these actions, and research is providing scientific explanations for them.
C1 [Molan, Peter] Univ Waikato, Hamilton, New Zealand.
   [Rhodes, Tanya] Rhodes & Assoc, Largo, FL USA.
C3 University of Waikato
RP Rhodes, T (通讯作者)，Rhodes & Assoc, Largo, FL USA.
EM trhodes6@tampabay.rr.com
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NR 98
TC 178
Z9 218
U1 2
U2 109
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2015
VL 27
IS 6
BP 141
EP 151
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CL8NL
UT WOS:000357231300003
PM 26061489
DA 2026-07-24
ER

PT J
AU McNulty, A
   Spranger, I
   Courage, J
   Green, J
   Wilkes, R
   Rycerz, A
AF McNulty, Amy
   Spranger, Ian
   Courage, James
   Green, Jeff
   Wilkes, Robert
   Rycerz, Anthony
TI The Consistent Delivery of Negative Pressure to Wounds Using
   Reticulated, Open Cell Foam and Regulated Pressure Feedback
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID FIBRIN MATRIX; THERAPY; TENSION; GROWTH; PROLIFERATION; GENESIS; TISSUES
AB Negative pressure wound therapy (NPWT) is used to manage wounds and promote wound healing. The most common form of NPWT utilizes reticulated, open cell foam (ROCF). Pressure is transferred to the wound by ROCF using T.R.A.C.(TM) Technology (regulated pressure feedback [RPF]) creating an environment that promotes healing. This study examines the effectiveness of ROCF versus gauze in inducing macrostrain and investigates the ability of NPWT/ROCF/RPF to consistently deliver negative pressure to the wound, compensating for constantly changing wound fluid characteristics. In an in-vitro model, ROCF induced significantly greater macrostrain than gauze demonstrating a 57% decrease in dressing surface area following negative pressure application. The decrease measured with gauze under suction (GUS) was insignificant. The NPWT/ROCF/RPF system consistently delivered negative pressure to the wound when compared to GUS or ROCF without RPF. Further, with the negative pressure source elevated 36 in (90 cm) above surrogate wounds, GUS demonstrated a 7- to 10-fold pressure drop when compared to NPWT/ROCF/RPF. Systems without RPF are limited because they cannot sense or measure pressure delivered at the wound. In situations where pressure drop occurs, neither the clinician nor patient would necessarily know that suboptimal pressure was being delivered to the wound. Therefore, a system with ROOF and RPF capability that effectively monitors and maintains the NPWT environment plays a crucial role in the optimal induction of macrostrain and microstrain. The ability of the NPWT/ROCF/RPF system to monitor and maintain controlled, consistent delivery of negative pressure would seem important to achieve desired clinical outcomes.
C1 [McNulty, Amy; Spranger, Ian; Courage, James; Green, Jeff; Wilkes, Robert; Rycerz, Anthony] Kinet Concepts Inc, San Antonio, TX USA.
RP McNulty, A (通讯作者)，Kinet Concepts Inc, 8023 Vantage Dr, San Antonio, TX USA.
EM amy.mcnulty@kci1.com
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NR 24
TC 14
Z9 16
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2010
VL 22
IS 5
BP 114
EP 120
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 603JL
UT WOS:000278204800002
PM 25902176
DA 2026-07-24
ER

PT J
AU Xiao, J
   He, ZK
   Bu, YT
   Lu, Y
   Liang, SB
AF Xiao, Jian
   He, Zekun
   Bu, Yitian
   Lu, Yan
   Liang, Shuibin
TI Exosome-Biomaterial Platforms for Diabetic Skin Infections:
   Microenvironment Remodeling, Responsive Delivery, and Clinical
   Translation
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Article
DE diabetic skin infection; diabetic foot ulcers; exosomes; biomaterials;
   microenvironment reprogramming; regenerative medicine
ID FOOT ULCERS; EPIDEMIOLOGY; MACROPHAGES; EXPRESSION; BURDEN
AB Diabetic skin infections, particularly diabetic foot ulcers (DFU), remain difficult to treat because infection, biofilm formation, persistent inflammation, oxidative stress, hypoxia, impaired angiogenesis, and extracellular matrix (ECM) disruption coexist within a hostile wound microenvironment. Conventional treatments, including antibiotics, surgical debridement, negative pressure wound therapy, and standard dressings, are indispensable but often fail to simultaneously suppress infection and restore regenerative healing. Exosomes have emerged as promising acellular mediators for diabetic wound repair because they can coordinate immune regulation, angiogenesis, matrix remodeling, and re-epithelialization. However, direct exosome administration is limited by rapid clearance, poor local retention, dilution by wound exudate, dose inconsistency, and manufacturing heterogeneity. Biomaterial platforms, including hydrogels, microneedle patches, membranes, cryogels, porous scaffolds, and responsive nanocomposite systems, provide a rational strategy to protect exosome bioactivity, prolong local retention, and enable sustained or stimulus-responsive release. More importantly, these materials can be engineered to actively regulate infection-associated pathological barriers, including biofilm persistence, excessive oxidative stress, hypoxia, and impaired tissue reconstruction. This review summarizes recent advances in exosome-biomaterial systems for diabetic skin infections, with emphasis on delivery design, microenvironment-responsive release, anti-infective and regenerative mechanisms, platform comparison, and clinical translation. We further discuss key translational challenges, including exosome source selection, dose standardization, potency assays, scalable manufacturing, storage stability, biosafety, regulatory classification, and clinical trial design. Current evidence suggests that exosome-biomaterial systems can improve wound closure, vascularization, collagen deposition, re-epithelialization, and infection control in preclinical models. Nevertheless, high-quality clinical evidence remains limited. Future studies should prioritize clinically relevant infected diabetic wound models, standardized quality-control frameworks, and simplified delivery systems compatible with routine wound care.
C1 [Xiao, Jian; Bu, Yitian; Lu, Yan] Jiaxing Univ, Peoples Hosp Jiashan 1, Jiashan Hosp, Jiaxing 314100, Peoples R China.
   [He, Zekun] Nanchang Mingzhou Rehabil Hosp, Dept Rehabil Treatment, Nanchang 330096, Peoples R China.
   [Liang, Shuibin] Zhejiang Chinese Med Univ, Jiaxing Hosp Tradit Chinese Med, Jiaxing 314000, Peoples R China.
C3 Jiaxing University; Zhejiang Chinese Medical University
RP Liang, SB (通讯作者)，Zhejiang Chinese Med Univ, Jiaxing Hosp Tradit Chinese Med, Jiaxing 314000, Peoples R China.
EM 18258372985@163.com
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NR 121
TC 0
Z9 0
U1 2
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-9114
EI 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2026
VL 21
AR 607504
DI 10.2147/IJN.S607504
PG 38
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA KM0MS
UT WOS:001810160400001
PM 42383230
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Addeo, P
   Noblet, V
   Naegel, B
   Bachellier, P
AF Addeo, Pietro
   Noblet, Vincent
   Naegel, Benoit
   Bachellier, Philippe
TI Large-for-Size Orthotopic Liver Transplantation: a Systematic Review of
   Definitions, Outcomes, and Solutions
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE Anthropometrics; Graft reduction; Large-for-size; Liver transplantation;
   Mismatch; Negative pressure wound therapy
ID BODY-WEIGHT RATIO; DECEASED DONOR; GRAFT WEIGHT; MODEL; PARAMETERS;
   RECIPIENTS; CLOSURE; IMPACT
AB Background We systematically reviewed the literature on definitions and outcomes of large-for-size (LFS) syndrome in orthotopic liver transplantation (LT). Methods This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Cochrane Library, PubMed, and Embase were searched (January 1990-January 2019) for studies reporting LFS in LT. Primary outcomes were definitions and mortality of LFS LT. Results Eleven studies reporting patients with LFS LT were identified. Four different formulas (graft-to-recipient weight ratio (GRWR), body surface area index (BSAi), donor standardized total liver volume (sTLV)-to-recipient sTLV ratio, and graft weight/right anteroposterior distance (RAP) ratio) with their critical thresholds were found. There were 81 patients (54% women) with a median weight and height of 62.5 kg (range, 40-105 kg) and 165 cm (range, 145-180 cm). The median graft weight was 1772 g (range, 1290-2400 g), and the median GWRW was 2.77% (range, 2.1-4.00%). Graft venous outflow obstruction was described in seven patients (8.6%). At the time of LT, fascial closure was not achieved in 24 patients (29.6%) and the graft size was reduced by a liver resection in three patients (3.7%). Thirteen deaths (16%) were reported in the first 90 postoperative days with two patients undergoing re-transplant. Conclusions LFS LT remains heterogeneously defined but characterized by high mortality rates despite the use of tailored surgical solutions (graft reduction and open abdomen). A composite definition is proposed in order to better describe LFS clinical syndrome.
C1 [Addeo, Pietro; Bachellier, Philippe] Univ Strasbourg, Hepatopancreatobiliary Surg & Liver Transplantat, Pole Pathol Digest Hepat & Transplantat, Hop Hautepierre,Hop Univ Strasbourg, 1 Ave Moliere, F-67098 Strasbourg, France.
   [Addeo, Pietro; Noblet, Vincent; Naegel, Benoit] Univ Strasbourg, ICube, CNRS UMR 7357, Illkirch Graffenstaden, France.
C3 CHU Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences
   (INSIS)
RP Addeo, P (通讯作者)，Univ Strasbourg, Hepatopancreatobiliary Surg & Liver Transplantat, Pole Pathol Digest Hepat & Transplantat, Hop Hautepierre,Hop Univ Strasbourg, 1 Ave Moliere, F-67098 Strasbourg, France.; Addeo, P (通讯作者)，Univ Strasbourg, ICube, CNRS UMR 7357, Illkirch Graffenstaden, France.
EM pietrofrancesco.addeo@chru-strasbourg.fr
RI ADDEO, Pietro/ADD-9196-2022; Noblet, Vincent/ABE-4264-2020
OI ADDEO, Pietro/0000-0003-0046-7973
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NR 24
TC 29
Z9 35
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD MAY
PY 2020
VL 24
IS 5
BP 1192
EP 1200
DI 10.1007/s11605-019-04505-5
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA LK9EE
UT WOS:000531159900028
PM 31919740
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Cheatham, ML
   Demetriades, D
   Fabian, TC
   Kaplan, MJ
   Miles, WS
   Schreiber, MA
   Holcomb, JB
   Bochicchio, G
   Sarani, B
   Rotondo, MF
AF Cheatham, Michael L.
   Demetriades, Demetrios
   Fabian, Timothy C.
   Kaplan, Mark J.
   Miles, William S.
   Schreiber, Martin A.
   Holcomb, John B.
   Bochicchio, Grant
   Sarani, Babak
   Rotondo, Michael F.
TI Prospective Study Examining Clinical Outcomes Associated with a Negative
   Pressure Wound Therapy System and Barker's Vacuum Packing Technique
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL HYPERTENSION;
   INTERNATIONAL-CONFERENCE; AMERICAN-ASSOCIATION; OPEN ABDOMEN; CLOSURE;
   MANAGEMENT; TRAUMA; COMPLICATION; SURGERY
AB The open abdomen has become a common procedure in the management of complex abdominal problems and has improved patient survival. The method of temporary abdominal closure (TAC) may play a role in patient outcome.
   A prospective, observational, open-label study was performed to evaluate two TAC techniques in surgical and trauma patients requiring open abdomen management: Barker's vacuum-packing technique (BVPT) and the ABThera(TM) open abdomen negative pressure therapy system (NPWT). Study endpoints were days to and rate of 30-day primary fascial closure (PFC) and 30-day all-cause mortality.
   Altogether, 280 patients were enrolled from 20 study sites. Among them, 168 patients underwent at least 48 hours of consistent TAC therapy (111 NPWT, 57 BVPT). The two study groups were well matched demographically. Median days to PFC were 9 days for NPWT versus 12 days for BVPT (p = 0.12). The 30-day PFC rate was 69 % for NPWT and 51 % for BVPT (p = 0.03). The 30-day all-cause mortality was 14 % for NPWT and 30 % for BVPT (p = 0.01). Multivariate logistic regression analysis identified that patients treated with NPWT were significantly more likely to survive than the BVPT patients [odds ratio 3.17 (95 % confidence interval 1.22-8.26); p = 0.02] after controlling for age, severity of illness, and cumulative fluid administration.
   Active NPWT is associated with significantly higher 30-day PFC rates and lower 30-day all-cause mortality among patients who require an open abdomen for at least 48 h during treatment for critical illness.
C1 [Cheatham, Michael L.] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL 32806 USA.
   [Demetriades, Demetrios] Los Angeles Cty Univ Southern Calif Med Ctr, Los Angeles, CA USA.
   [Fabian, Timothy C.] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA.
   [Kaplan, Mark J.] Albert Einstein Med Ctr, Philadelphia, PA 19141 USA.
   [Miles, William S.] Carolinas Med Ctr, Charlotte, NC 28203 USA.
   [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Portland, OR USA.
   [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
   [Bochicchio, Grant] Univ Maryland, Baltimore, MD 21201 USA.
   [Sarani, Babak] Univ Penn, Pittsburgh, PA USA.
   [Rotondo, Michael F.] E Carolina Univ, Greenville, NC USA.
C3 Orlando Health; Orlando Regional Medical Center; University of Tennessee
   System; University of Tennessee Health Science Center; Yeshiva
   University; Carolinas Medical Center; Oregon Health & Science
   University; University of Texas System; University of Texas Health
   Science Center Houston; University System of Maryland; University of
   Maryland Baltimore; University of Pennsylvania; University of North
   Carolina; East Carolina University
RP Cheatham, ML (通讯作者)，Orlando Reg Med Ctr Inc, Dept Surg Educ, 86 West Underwood St,Suite 201, Orlando, FL 32806 USA.
EM michael.cheatham@orlandohealth.com
RI ; Martin, Schreiber/F-2175-2013
OI holcomb, john/0000-0001-8312-9157; Sarani, Babak/0000-0001-6247-3004; 
CR Acosta S, 2011, BRIT J SURG, V98, P735, DOI 10.1002/bjs.7383
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   Cheatham ML, 2011, AM SURGEON, V77, pS78
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   MacLean AA, 2008, ACTA CHIR BELG, V108, P212, DOI 10.1080/00015458.2008.11680206
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   Vargo D, 2009, AM SURGEON, V75, pS1
   Vidal MG, 2008, CRIT CARE MED, V36, P1823, DOI 10.1097/CCM.0b013e31817c7a4d
NR 27
TC 131
Z9 159
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD SEP
PY 2013
VL 37
IS 9
BP 2018
EP 2030
DI 10.1007/s00268-013-2080-z
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 204MM
UT WOS:000323369400002
PM 23674252
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Tran, R
   Haffner, ZK
   Slamin, RP
   Akbari, CM
   Evans, KK
AF Tran, Ryu
   Haffner, Zoe K.
   Slamin, Robert P.
   Akbari, Cameron M.
   Evans, Karen K.
TI Arterialized Vein Bypass Graft Recipient Vessel in Free Tissue Transfer
   Covering Diabetic Foot Ulcers Complicated by Critical Limb Ischemia
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article; Proceedings Paper
CT 38th Annual Meeting of the Northeastern-Society-of-Plastic-Surgeons
   (NESPS)
CY SEP 30-OCT 02, 2022
CL Boston, MA
DE limb salvage; lower extremity; plastic surgery; reconstruction; vein
   bypass graft; free tissue transfer; critical limb ischemia; diabetes
   mellitus; infection; antibiotic spacer; negative pressure wound therapy;
   skin graft; osteomyelitis; nonhealing wound; debridement; saphenous vein
   graft
ID IN-SITU; AMPUTATION; SALVAGE; FLOW
AB Limb salvage options are limited in diabetic patients with critical limb ischemia. Soft tissue coverage remains technically demanding with limited recipient vessels for free tissue transfer. These factors make revascularization alone challenging. When open bypass revascularization is possible, venous bypass graft is optimal and functions as a recipient vessel for staged free tissue transfer.The authors present 2 cases using a combination approach of staged venous bypass graft revascularization followed by free tissue transfer with anastomosis to the venous bypass graft resulting in successful limb preservation.Free tissue transfer to a native vessel has limited application in severe peripheral vascular disease patients because early vascular compromise threatens flap survival. In both presented cases, venous bypass graft alone was insufficient to treat their nonhealing wounds, and preoperative angiogram revealed dismal options for free tissue transfer reconstruction. However, previous venous bypass graft provided an operable vessel for free tissue transfer anastomosis. The combination of venous bypass graft and free tissue transfer proved to be ideal for successful limb preservation by providing vascularized tissue to previously ischemic angiosomes, ensuring optimal wound healing capacity. Venous bypass graft is advantageous to native arterial grafts, and its combination with free tissue transfer likely increases graft patency and flap survival. We demonstrate that end-to-side anastomosis to a venous bypass graft is a viable option in these highly comorbid patients with favorable flap outcomes.
C1 [Tran, Ryu] Georgetown Univ, Sch Med, Washington, DC USA.
   [Haffner, Zoe K.; Slamin, Robert P.; Evans, Karen K.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, Washington, DC USA.
   [Akbari, Cameron M.] MedStar Georgetown Univ Hosp, Dept Vasc Surg, Washington, DC USA.
   [Tran, Ryu] 5332 Knole Ct Apt 242, Alexandria, VA 22311 USA.
C3 Georgetown University; Georgetown University; Georgetown University
RP Tran, R (通讯作者)，5332 Knole Ct Apt 242, Alexandria, VA 22311 USA.
EM rt729@georgetown.edu; zkh@georgetown.edu; robert.p.slamin@medstar.net;
   Cameron.akbari@medstar.net; prsgeorgetownresearch@gmail.com
CR Almasri J, 2019, EUR J VASC ENDOVASC, V58, pS110, DOI 10.1016/j.ejvs.2019.04.013
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NR 15
TC 1
Z9 1
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2023
VL 90
IS 6S
SU 5
BP S570
EP S573
DI 10.1097/SAP.0000000000003406
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA L3MZ9
UT WOS:001022348000024
PM 37399481
DA 2026-07-24
ER

PT J
AU Ring, A
   Beutel, H
   Bushart, SU
   Dellmann, NC
   Gousias, K
AF Ring, Andrej
   Beutel, Hendrik
   Bushart, Sebastian Ulrich
   Dellmann, Niklas-Chris
   Gousias, Konstantinos
TI Perforator-based keystone flap in the reconstruction of extensive tissue
   defects after lumbosacral spondylodesis
SO UNFALLCHIRURGIE
LA German
DT Article
DE Spinal surgery; Surgical site infection; NPWT; Reconstruction; Plastic
   surgery
ID SPINAL SURGERY; ISLAND FLAP; INFECTION; MANAGEMENT; OPTIONS
AB Background Prolonged surgical site infections after spinal fusion surgery may lead to exposure of the implant due to the formation of extensive tissue defects and endanger the clinical outcome. Objective This study aims to enlighten the role of the keystone perforator flap method in the reconstruction of lumbar soft tissue defects. Material and methods The retrospective study included 11 consecutive patients with a wound dehiscence of over 6 x 6 cm defect area persisting for 2 weeks after spinal fusion. The keystone perforator flap was applied for the reconstruction of tissue defects, whereas the arterial blood supply of the flaps was based on the intramuscular and intermuscular perforating branches of the dorsal branches of the lumbar arteries. Results The median age of our cohort was 58 years. The median body mass index (BMI) and Charlson comorbidity index (CCI) were 29.9 and 3.4, respectively. In eight cases a lumbosacral was carried out whereas in the remaining series a lumbar fusion was performed. In the course of the subsequent wound revision, on average 4 applications of negative pressure wound therapy (NPWT) were performed. The average defect size was 7.5 cm in width and 16.5 cm in length. The microbiological analysis of the tissue samples obtained intraoperatively after repeated NPWT revealed positive evidence of pathogenic bacteria in all cases. The average duration of inpatient treatment after flap surgery was 15 days, which was significantly shorter than the NPWT management of the open defect wounds (15.5 +/- 2.5 vs. 37 +/- 16.5, p < 0.05). Conclusion The keystone perforator flap offers a stable coverage for soft tissue defects and supports infection control after spinal fusion.
C1 [Ring, Andrej; Bushart, Sebastian Ulrich; Dellmann, Niklas-Chris] Katholische St Paulus Gesell, Klin Plast Chirurg, St Rochus Hosp, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
   [Beutel, Hendrik] Ruhr Univ, Bochum, Germany.
   [Gousias, Konstantinos] Katholische St Paulus Gesell, Klin Neurochirurg, St Marien Hosp, Lunen, Germany.
C3 Ruhr University Bochum; St. Marien Hospital
RP Ring, A (通讯作者)，Katholische St Paulus Gesell, Klin Plast Chirurg, St Rochus Hosp, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
EM andrej.ring@rub.de
RI Ring, Anej/AAK-1768-2021
OI Ring, Anej/0000-0002-2202-6370
CR Behan F, 2003, ANZ J SURG, V73, P112, DOI 10.1046/j.1445-2197.2003.02638.x
   Behan F, 2006, ANZ J SURG, V76, P407, DOI 10.1111/j.1445-2197.2006.03708.x
   Behr B, 2014, HANDCHIR MIKROCHIR P, V46, P90, DOI 10.1055/s-0034-1370994
   Beiner John M, 2003, Neurosurg Focus, V15, pE14
   Bissell MB, 2016, ANN PLAS SURG, V77, P469, DOI 10.1097/SAP.0000000000000646
   Chahoud J, 2014, FRONT MED-LAUSANNE, V1, DOI 10.3389/fmed.2014.00007
   Chen SH, 2018, CLIN SPINE SURG, V31, P225, DOI 10.1097/BSD.0000000000000633
   Di Martino A, 2019, EUR REV MED PHARMACO, V23, P173, DOI 10.26355/eurrev_201904_17487
   Fang XT, 2013, CHINESE MED J-PEKING, V126, P3817, DOI 10.3760/cma.j.issn.0366-6999.20131441
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   Kasliwal Manish K, 2013, Surg Neurol Int, V4, pS392, DOI 10.4103/2152-7806.120783
   Kiil BJ, 2009, PLAST RECONSTR SURG, V123, P1229, DOI 10.1097/PRS.0b013e31819f299e
   Kolbenschlag J, 2015, ZBL CHIR, V140, P179, DOI 10.1055/s-0035-1545782
   Lall RR, 2015, J CLIN NEUROSCI, V22, P238, DOI 10.1016/j.jocn.2014.07.010
   Maruo K, 2014, J ORTHOP SCI, V19, P398, DOI 10.1007/s00776-014-0545-z
   Mujtaba B, 2019, CLIN RADIOL, V74, P756, DOI 10.1016/j.crad.2019.05.032
   Parpaley Y, 2011, NEUROSURGERY, V68, pE277, DOI 10.1227/NEU.0b013e3181fead14
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   Smith JS, 2011, SPINE, V36, P556, DOI 10.1097/BRS.0b013e3181eadd41
NR 21
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2731-7021
EI 2731-703X
J9 UNFALLCHIRURGIE
JI Unfallchirurgie
PD DEC
PY 2022
VL 125
IS 12
SI SI
BP 975
EP 982
DI 10.1007/s00113-021-01128-x
EA JAN 2022
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 6O5XI
UT WOS:000737775000001
PM 34981136
DA 2026-07-24
ER

PT J
AU Rotering, H
   Al Shakaki, M
   Welp, H
   Dell'Aquila, AM
AF Rotering, Heinrich
   Al Shakaki, Mosab
   Welp, Henryk
   Dell'Aquila, Angelo M.
TI Preliminary Results of a New Treatment Strategy for Relapsed Left
   Ventricular Assist Device-Specific Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID COLD ATMOSPHERIC PLASMA; MANAGEMENT; DIAGNOSIS; CONSENSUS; TRIAL; PUMP
AB Background. Relapsed ventricular assist device-specific infections are associated with high morbidity, mortality, and hospital costs. A new combination of cold atmospheric plasma and special dressing technique with negative pressure wound therapy with an additional underlay of carbon cloth and hypochlorite rinsing solutions has been developed and reported in this study.
   Methods. Between January 2016 and January 2018, 9 patients with relapsed infected driveline or pump pocket infection were treated with this new combined strategy. The primary endpoint was complete wound healing without recurrence of infection, defined as the presence at the same site within the first year after treatment. The secondary endpoint was control of infection, defined as a marked reduction of the infected area.
   Results. After a median treatment time of 3 weeks, an immediate response was observed in all patients, and complete healing was achieved in 6 patients. Five patients met the primary endpoint, and infection did not recur after a median follow-up of 17.5 (range, 12.1 to 21.8) months. One patient underwent heart transplantation 6 months after successful wound treatment (complete wound healing). The remaining 3 patients were discharged with controlled infection. After a median follow-up of 5.7 months, 1 destination therapy patient died at home, and 2 patients underwent urgent heart transplantation because of recurrence of infection caused by Pseudomonas aeruginosa. Side effects were not observed.
   Conclusions. The new combination treatment offers a promising option for patients with ventricular assist device-relapsed infection. Despite this, further studies are warranted to confirm those encouraging preliminary results. (C) 2020 by The Society of Thoracic Surgeons
C1 [Rotering, Heinrich; Al Shakaki, Mosab; Welp, Henryk; Dell'Aquila, Angelo M.] Univ Hosp Munster, Dept Cardiac Surg, Munster, Germany.
C3 University of Munster
RP Dell'Aquila, AM (通讯作者)，Univ Hosp, Dept Thorac & Cardiovasc Surg, Albert Schweitzer Campus 1, D-48149 Munster, Germany.
EM am.dellaquila@gmail.com
RI Dell'Aqula, Angelo M/AAJ-6462-2021
OI Dell'Aqula, Angelo M/0000-0002-5748-4275
FU Hounslow, Middlesex, United Kingdom
FX The MicroPlaSter device was lent free of charge for treatment in the
   period from January 2016 to March 2017 by Adtec Healthcare, Hounslow,
   Middlesex, United Kingdom.
CR ActiMaris, GEN INF ACTIMARIS SE
   Akhter SA, 2015, ANN THORAC SURG, V100, P884, DOI 10.1016/j.athoracsur.2015.03.010
   Arndt S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120041
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   Dell'Aquila AM, 2016, ANN THORAC SURG, V101, P87, DOI 10.1016/j.athoracsur.2015.06.066
   Flynn PB, 2015, INT J ANTIMICROB AG, V46, P101, DOI 10.1016/j.ijantimicag.2015.02.026
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   Sharma V, 2012, ANN THORAC SURG, V94, P1381, DOI 10.1016/j.athoracsur.2012.05.074
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   Weiss M, 2017, J MED VIROL, V89, P952, DOI 10.1002/jmv.24701
NR 28
TC 5
Z9 6
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2020
VL 110
IS 4
BP 1302
EP 1307
DI 10.1016/j.athoracsur.2020.02.007
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA NW7VM
UT WOS:000575226700029
PM 32169499
DA 2026-07-24
ER

PT J
AU Borys, S
   Ludwig-Slomczynska, AH
   Seweryn, M
   Hohendorff, J
   Koblik, T
   Machlowska, J
   Kiec-Wilk, B
   Wolkow, P
   Malecki, MT
AF Borys, S.
   Ludwig-Slomczynska, A. H.
   Seweryn, M.
   Hohendorff, J.
   Koblik, T.
   Machlowska, J.
   Kiec-Wilk, B.
   Wolkow, P.
   Malecki, Maciej T.
TI Negative pressure wound therapy in the treatment of diabetic foot ulcers
   may be mediated through differential gene expression
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Diabetic foot syndrome; Wound healing; NPWT; Gene expression
ID BINDING
AB AimsNegative pressure wound therapy (NPWT) has been successfully used as a treatment for diabetic foot ulceration (DFU). Its mechanism of action on the molecular level, however, is not fully understood. We assessed the effect of NPWT on gene expression in patients with type 2 diabetes (T2DM) and DFU.MethodsWe included two cohorts of patientsindividuals treated with either NPWT or standard therapy. The assignment to NWPT was non-randomized and based on wound characteristics. Differential gene expression profiling was performed using Illumina gene expression arrays and R Bioconductor pipelines based on the limma' package.ResultsThe final cohort encompassed 21 patients treated with NPWT and 8 with standard therapy. The groups were similar in terms of age (69.0 versus 67.5years) and duration of T2DM (14.5 versus 14.4years). We identified four genes differentially expressed between the two study arms post-treatment, but not pre-treatment: GFRA2 (GDNF family receptor alpha-2), C1QBP (complement C1q binding protein), RAB35 (member of RAS oncogene family) and SYNJ1 (synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1). Interestingly, all four genes seemed to be functionally involved in wound healing by influencing re-epithelialization and angiogenesis. Subsequently, we utilized co-expression analysis in publicly available RNA-seq data to reveal the molecular functions of GFRA2 and C1QBP, which appeared to be through direct protein-protein interactions.ConclusionsWe found initial evidence that the NPWT effect on DFUs may be mediated through differential gene expression. A discovery of the specific molecular mechanisms of NPWT is potentially valuable for its clinical application and development of new therapies.
C1 [Borys, S.; Hohendorff, J.; Kiec-Wilk, B.; Malecki, Maciej T.] Jagiellonian Univ, Dept Metab Dis, Coll Med, 15 Kopernika St, PL-31501 Krakow, Poland.
   [Borys, S.; Hohendorff, J.; Koblik, T.; Kiec-Wilk, B.; Malecki, Maciej T.] Univ Hosp, Krakow, Poland.
   [Ludwig-Slomczynska, A. H.; Seweryn, M.; Machlowska, J.; Wolkow, P.] Jagiellonian Univ, Ctr Med Genom OMICRON, Coll Med, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Malecki, MT (通讯作者)，Jagiellonian Univ, Dept Metab Dis, Coll Med, 15 Kopernika St, PL-31501 Krakow, Poland.; Malecki, MT (通讯作者)，Univ Hosp, Krakow, Poland.
EM malecki_malecki@yahoo.com
RI ; Seweryn, Michal/OEO-9216-2025; Wolkow, Pawel/AAI-4222-2021;
   Hohendorff, Jerzy/U-1857-2018
OI Ludwig-Słomczyńska, Agnieszka H/0000-0002-0548-4767; Machlowska,
   Julita/0000-0001-9951-9248; Seweryn, Michal/0000-0002-9090-3435; Wolkow,
   Pawel/0000-0002-9322-5545; Hohendorff, Jerzy/0000-0003-1153-8669
FU National Science Centre in Poland [2013/11/B/NZ5/03298]; European Union
   (7th Framework Programme) [286038]
FX The study was funded by the National Science Centre in Poland through
   251 the Opus Grant "Assessment of molecular mechanisms of negative
   pressure wound therapy in the treatment of neuropathic ulceration in
   diabetic foot syndrome" to MTM (Nr 2013/11/B/NZ5/03298). The Omicron
   laboratory (where the microarray experiments were performed) was funded
   by the European Union (7th Framework Programme, Call number
   FP7-REGPOT-2011-1, Grant number 286038).
CR Allaire PD, 2013, J CELL SCI, V126, P722, DOI 10.1242/jcs.112375
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NR 20
TC 14
Z9 17
U1 0
U2 19
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JAN
PY 2019
VL 56
IS 1
BP 115
EP 120
DI 10.1007/s00592-018-1223-y
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ7OV
UT WOS:000457388100014
PM 30221321
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Bauerle, W
   Evans, J
   Lee, R
   Worobetz, N
   Reese, V
   Sanders, C
AF Bauerle, Wayne
   Evans, Joseph
   Lee, Ryan
   Worobetz, Nestor
   Reese, Vanessa
   Sanders, Christopher
TI Negative Pressure Therapy Postabdominal Body Contouring in Bariatric
   Surgery Patients
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE abdominoplasty; massive weight loss; abdominal body contouring; body
   contouring; negative pressure; negative pressure wound dressing;
   incisional dressing; PICO; Prevena; bariatric surgery
ID MASSIVE WEIGHT-LOSS; SURGICAL-SITE INFECTIONS; WOUND THERAPY;
   COMPLICATIONS; MANAGEMENT
AB Background: The primary aim of this study was to investigate the effects of Incisional Negative Pressure Wound Therapy (iNPWT) on surgical site complication rates for abdominal body contouring following bariatric surgery that resulted in massive weight loss. Methods: A large 15-hospital retrospective case-control study was conducted. Inclusion criteria consisted of nonsmokers who achieved massive weight loss, defined as > 100 lb or > 50% excess body weight, and had an abdominal body contouring surgery between January 2021 and June 2024. We conducted separate unadjusted analyses comparing the iNPWT cohort to the control cohort using separate chi-square or Fisher exact tests for categorical variables, and independent samples t tests or Mann-Whitney rank sums tests for normally distributed and skewed continuous variables, respectively. Statistical significance was set to P = 0.05. Results: Basic demographics were similar for a majority of the variables between the iNPWT cohort and the standard cohort. Minor wound complications following abdominal body contouring surgery did not significantly differ between the standard and iNPWT (40.54% vs 36.36%, P = 0.070) cohorts. However, among major wound complications, rates of wound dehiscence (22.97% vs 2.27%, P = 0.003) and infection (21.62% vs 6.82%, P = 0.040) were significantly lower in the iNPWT cohort. There was no significant difference in hematoma or seroma formation between the 2 groups. Conclusion: Given the high volume of patients undergoing abdominal body contouring surgery following bariatric surgery, iNPWT dressings can provide plastic surgeons with an adjunct to further reduce the incidence of wound dehiscence and wound infection.
C1 [Bauerle, Wayne; Evans, Joseph; Worobetz, Nestor] St Lukes Univ Hlth Network, Dept Surg, 801 Ostrum St, Bethlehem, PA 18015 USA.
   [Lee, Ryan] Temple St Lukes Sch Med, Bethlehem, PA USA.
   [Reese, Vanessa] St Lukes Univ Hlth Network, Dept Res & Innovat, Bethlehem, PA USA.
   [Sanders, Christopher] St Lukes Univ Hlth Network, Dept Plast & Reconstruct Surg, Bethlehem, PA USA.
RP Bauerle, W (通讯作者)，St Lukes Univ Hlth Network, Dept Surg, 801 Ostrum St, Bethlehem, PA 18015 USA.
EM wbauerle1@gmail.com; joseph.evans@sluhn.org; rlee1682@gmail.com;
   nestor.worobetz@sluhn.org; vanessa.reese@sluhn.org;
   christopher.sanders@sluhn.org
CR Abesamis GM, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002141
   Altieri MS, 2017, OBES SURG, V27, P2981, DOI 10.1007/s11695-017-2732-4
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2026
VL 96
SU 5
BP S353
EP S358
DI 10.1097/SAP.0000000000004617
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IA3GV
UT WOS:001766939500018
PM 41587358
DA 2026-07-24
ER

PT J
AU Leary, OP
   Setty, A
   Gong, JH
   Ali, R
   Fridley, JS
   Fisher, CG
   Sahgal, A
   Rhines, LD
   Reynolds, JJ
   Lazary, A
   Laufer, I
   Gasbarrini, A
   Dea, N
   Verlaan, JJ
   Bettegowda, C
   Boriani, S
   Mesfin, A
   Luzzati, A
   Shin, JH
   Cecchinato, R
   Hornicek, FJ
   Goodwin, ML
   Gokaslan, ZL
AF Leary, Owen P.
   Setty, Aayush
   Gong, Jung Ho
   Ali, Rohaid
   Fridley, Jared S.
   Fisher, Charles G.
   Sahgal, Arjun
   Rhines, Laurence D.
   Reynolds, Jeremy J.
   Lazary, Aron
   Laufer, Ilya
   Gasbarrini, Alessandro
   Dea, Nicolas
   Verlaan, Jorrit-Jan
   Bettegowda, Chetan
   Boriani, Stefano
   Mesfin, Addisu
   Luzzati, Alessandro
   Shin, John H.
   Cecchinato, Riccardo
   Hornicek, Francis J.
   Goodwin, Matthew L.
   Gokaslan, Ziya L.
TI Prevention and Management of Posterior Wound Complications Following
   Oncologic Spine Surgery: Narrative Review of Available Evidence and
   Proposed Clinical Decision-Making Algorithm
SO GLOBAL SPINE JOURNAL
LA English
DT Article
DE surgical site infection; wound dehiscence; spinal oncology; clinical
   algorithm; spine surgery
ID SURGICAL-SITE-INFECTION; VANCOMYCIN POWDER; RISK-FACTORS; EN-BLOC;
   ANTIBIOTIC-THERAPY; FUSION; MORTALITY; OUTCOMES; DISEASE; QUALITY
AB Study DesignNarrative Review.ObjectiveContextualized by a narrative review of recent literature, we propose a wound complication prevention and management algorithm for spinal oncology patients. We highlight available strategies and motivate future research to identify optimal and individualized wound management for this population.MethodsWe conducted a search of recent studies (2010-2022) using relevant keywords to identify primary literature in support of current strategies for wound complication prevention and management following spine tumor surgery. When primary literature specific to spine tumor cases was not available, data were extrapolated from studies of other spine surgery populations. Results were compiled into a proposed clinical algorithm to guide practice considering available evidence.ResultsBased on available literature, we recommend individualized stratification of patients according to identifiable risk factors for wound complication and propose several interventions which might be employed preventatively, including intrawound antibiotic administration, negative pressure wound therapy, and primary flap closure of the surgical wound. Of these, the available evidence, weighing possible risks vs benefits, most strongly favors primary flap closure of surgical wounds, particularly for patients with multiple risk factors. A secondary algorithm to guide management of wound complications is also proposed.ConclusionsWound complications such as SSI and dehiscence remain a significant source of morbidity following spine tumor surgery. Triaging patients on an individualized basis according to risk factors for complication may aid in selecting appropriate prophylactic strategies to prevent these complications. Future research in this area is still needed to strengthen recommendations.
C1 [Leary, Owen P.; Setty, Aayush; Gong, Jung Ho; Ali, Rohaid; Fridley, Jared S.; Gokaslan, Ziya L.] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Neurosurg, APC-6, Providence, RI 02903 USA.
   [Fisher, Charles G.; Dea, Nicolas] Univ British Columbia, Combined Neurosurg & Orthopaed Spine Program, Vancouver, BC, Canada.
   [Sahgal, Arjun] Univ Toronto, Sunnybrook Hosp, Dept Radiat Oncol, Toronto, ON, Canada.
   [Rhines, Laurence D.] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA.
   [Reynolds, Jeremy J.] Oxford Univ Hosp, Oxford Spinal Surg Unit, Oxford, England.
   [Lazary, Aron] Buda Hlth Ctr, Natl Ctr Spinal Disorders, Budapest, Hungary.
   [Laufer, Ilya] NYU, Grossman Sch Med, Dept Neurosurg, New York, NY USA.
   [Gasbarrini, Alessandro; Boriani, Stefano] Univ Bologna, Ist Ortoped Rizzoli, Bologna, Italy.
   [Verlaan, Jorrit-Jan] Univ Med Ctr Utrecht, Dept Orthoped, Utrecht, Netherlands.
   [Bettegowda, Chetan] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD USA.
   [Mesfin, Addisu] Georgetown Univ, Medstar Orthopaed Inst, Sch Med, Dept Orthopaed Surg, Washington, DC USA.
   [Luzzati, Alessandro; Cecchinato, Riccardo] Ambrogio Hosp, IRCCS Galeazzi, Milan, Italy.
   [Shin, John H.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA USA.
   [Hornicek, Francis J.] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL USA.
   [Goodwin, Matthew L.] Washington Univ, Sch Med St Louis, Dept Orthopaed Surg, St Louis, MO USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   University of British Columbia; University of Toronto; Sunnybrook
   Research Institute; Sunnybrook Health Science Center; University of
   Texas System; UTMD Anderson Cancer Center; New York University; IRCCS
   Istituto Ortopedico Rizzoli; University of Bologna; Utrecht University;
   Utrecht University Medical Center; Johns Hopkins University; Georgetown
   University; IRCCS Istituto Ortopedico Galeazzi; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard Medical School; University of Miami; Saint Louis University;
   Washington University (WUSTL)
RP Leary, OP (通讯作者)，Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Dept Neurosurg, APC-6, Providence, RI 02903 USA.
EM owen_leary@brown.edu
RI ; Lazary, Aron/LKL-6634-2024; Cecchinato, Riccardo/H-3283-2013
OI Gong, Jung Ho/0000-0003-0382-8279; Lazary, Aron/0000-0002-0157-719X;
   Leary, Owen/0000-0002-6282-828X; 
FU AO Spine
FX The authors would additionally like to thank Kendall Rivera-Lane BA for
   contributing the original illustration for this article; Samathalee
   Obiorah MD, Albert Woo MD, and Luke Soliman BS for contributing to an
   earlier version of the drafted text; and Kyle Mueller MD for insights
   related to the use of negative pressure wound therapy in spinal surgery.
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NR 121
TC 7
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2192-5682
EI 2192-5690
J9 GLOB SPINE J
JI Glob. Spine J.
PD JAN
PY 2025
VL 15
IS 1_SUPPL
SU 1_SUPPL
SI SI
BP 143S
EP 156S
DI 10.1177/21925682241237486
PG 14
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA S3B6R
UT WOS:001397023800011
PM 39801119
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lee, SH
   Kim, MB
   Jeon, YJ
AF Lee, Seung Hoo
   Kim, Min Bom
   Jeon, Yeong June
TI Role of bone single photon emission computed tomography/computed
   tomography in managing chronic fracture-related infections: Determining
   the depth of infection and avoiding unnecessary bone procedures
SO JOURNAL OF ORTHOPAEDIC SURGERY
LA English
DT Article
DE fracture-related infection; chronic osteomyelitis; post-traumatic
   osteomyelitis; bone SPECT/CT
ID OSTEOMYELITIS; DIAGNOSIS; SPECT/CT; MANAGEMENT
AB PurposeFracture-related infections (FRIs) encompass a broad range of infections associated with bone fractures; they remain a significant clinical challenge. Here, we aimed to investigate the viability of focusing on soft-tissue management in patients suspected of chronic FRI, who exhibit no significant bony uptake on bone single photon emission computed tomography (SPECT)/computed tomography (CT) scans.MethodsBetween January 2016 and January 2022, we managed 25 patients with chronic FRI or post-traumatic osteomyelitis using technetium 99m-methyl diphosphonate bone SPECT/CT to assess infection depth. Among them, 13 patients showing negligible bony uptake were included and categorized into two groups based on wound discharge reaching the bone/implant (Criteria 1, n = 6) or not (Criteria 2, n = 7).ResultsPatients in the Criteria 1 group were treated with antibiotics and soft tissue debridement without bony procedure. The average duration of antibiotic therapy was 6.7 weeks. Treatments were individualized, including implant changes, local flaps, skin grafts, and negative pressure wound therapy. No recurrence was reported in the mean follow-up of 21.3 months. Patients in the Criteria 2 group were treated with oral antibiotics (mean duration: 5.9 weeks) and daily wound dressings. No recurrence was reported in the mean follow-up of 26.0 months, and no surgical interventions were required.ConclusionThis study demonstrates the feasibility of focusing on soft-tissue management in patients with chronic FRI showing minimal bony uptake on bone SPECT/CT. Our treatment protocol avoided unnecessary surgical bone procedures, resulting in successful clinical outcomes with no recurrences.
C1 [Lee, Seung Hoo] Chungnam Natl Univ, Chungnam Natl Univ Sejong Hosp, Dept Orthopaed Surg, Coll Med, Sejong, South Korea.
   [Kim, Min Bom; Jeon, Yeong June] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Orthoped Surg, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea.
C3 Chungnam National University; Seoul National University (SNU); Seoul
   National University Hospital
RP Kim, MB (通讯作者)，Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Orthoped Surg, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea.
EM minbom@gmail.com
RI Kim, Min Bom/E-6964-2012; Lee, Seung Hoo/IQW-9408-2023
OI Kim, Min Bom/0000-0001-8335-9331; Lee, Seung Hoo/0000-0001-8260-4358
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NR 21
TC 1
Z9 1
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1022-5536
EI 2309-4990
J9 J ORTHOP SURG-HONG K
JI J. Orthop. Surg.
PD MAY
PY 2024
VL 32
IS 2
AR 10225536241264977
DI 10.1177/10225536241264977
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA UU4B1
UT WOS:001250549000001
PM 38897599
OA gold
DA 2026-07-24
ER

PT J
AU Buck, DW II
AF Buck, Donald W., II
TI Innovative Bioactive Glass Fiber Technology Accelerates Wound Healing
   and Minimizes Costs: A Case Series
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Editorial Material
DE advanced wound matrix; bioactive glass; chronic wound; cost analysis;
   ulcer; wound care
AB OBJECTIVE: To evaluate the efficacy and value of a novel borate-based bioactive glass fiber (BBGF) advanced wound matrix in the treatment of chronic wounds.
   METHODS: Four patients with chronic wounds that had failed multiple prior treatments were identified and treated with the BBGF technology. Patient demographics, wound characteristics, and prior treatment history were obtained. Costs associated with prior treatments were estimated and recorded using available cost data.
   RESULTS: The average wound duration prior to initiation of BBGF treatment was 391 days. All of the patients had a history of multiple failed interventions, including operative procedures, negative-pressure wound therapy, cellular and/or tissue-based products, dermal grafts, and synthetic wound matrices. Prior interventions resulted in an average estimated cost of $87,750 per patient. All of the patients achieved complete wound closure in an average of 55 days using BBGF treatment. Patients were treated with 3.3 applications of the BBGF product on average, with an average cost of $3,564. The use of the BBGF advanced wound matrix on initial presentation could have saved the healthcare system an average of $84,186 per patient and reduced wound duration by an average of 336 days.
   CONCLUSIONS: The BBGF advanced wound matrix resulted in the healing of chronic wounds that had failed multiple prior interventions. In this series of challenging cases, BBGF accelerated healing while minimizing costs and improving patient outcomes. By offering an effective therapy at a low cost, BBGF has the potential to add significant value for both the healthcare system and the patient.
C1 [Buck, Donald W., II] Buck Surg LLC, St Louis, MO 63110 USA.
RP Buck, DW II (通讯作者)，Buck Surg LLC, St Louis, MO 63110 USA.
CR Centers For Medicare & Medicaid Services, 2019, Medicare provider utilization and payment data: physician and other supplier
   Di Z, 2007, KEY ENG MATER, V330-332, P173, DOI 10.4028/www.scientific.net/KEM.330-332.173
   Han G, 2017, ADV THER, V34, P599, DOI 10.1007/s12325-017-0478-y
   Kim JJ, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001211
   Miguez-Pacheco V, 2015, ACTA BIOMATER, V13, P1, DOI 10.1016/j.actbio.2014.11.004
   Ottomeyer M, 2016, Advances in Microbiology, V06, P776, DOI [10.4236/aim.2016.610076, 10.4236/aim.2016.610076, DOI 10.4236/AIM.2016.610076, 10.4236/aim.2016.610075]
   Rahaman MN, 2011, ACTA BIOMATER, V7, P2355, DOI 10.1016/j.actbio.2011.03.016
NR 7
TC 10
Z9 13
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2020
VL 33
IS 8
DI 10.1097/01.ASW.0000672504.15532.21
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA MU2HT
UT WOS:000555495000002
PM 32697477
DA 2026-07-24
ER

PT J
AU Rupert, P
AF Rupert, P.
TI Human acellular dermal wound matrix for complex diabetic wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Wound healing; diabetic foot ulcers; acellular tissue matrix
ID REGENERATIVE TISSUE MATRIX; FOOT ULCERS; RECONSTRUCTION; MANAGEMENT;
   THERAPY; COSTS; CARE
AB Objective: Diabetic ulcers are the most common foot injuries leading to lower-extremity amputation and the most common cause of non-traumatic lower extremity amputations in the industrialised world. Approximately 85% of all diabetes-related lower-extremity amputations are preceded by foot ulcers. When foot ulcers develop despite preventive measures, early and appropriate treatment should be initiated to help reduce the burden of diabetes-related amputations. Recent advances now offer these patients a regenerative process of restoring the wound with human integument by replacing damaged or missing tissue with similar tissue rather than scar formation. The aim of this product evaluation was to test the efficacy of regenerative products on complex diabetic wounds.
   Method: Before wound intervention, the underlying comorbidities of type II diabetes mellitus and osteomyelitis were treated. In the operating room, the wounds received a sterile surgical scrub and were treated with either regenerative tissue matrix sutured over the open wounds or regenerative flowable soft tissue scaffold placed in a plantar tunnelled wound. Negative pressure wound therapy (NPWT) was applied for 10-14 days to create an environment that promotes wound healing, to secure the grafts, and to facilitate adhesion of the matrix to the wound bed.
   Results: All wounds, three in two patients, completely epithelialised without any complications at the end of the 17-week follow-up period.
   Conclusion: With the absence of complications and successful wound epithelialisation in a variety of diabetic wounds, regenerative tissue matrix products have taken the next step forward in wound healing. l Declaration of interest: PR is a consultant for KCI, an Acelity company.
C1 [Rupert, P.] Houston Methodist Hosp, Dept Surg, 6550 Fannin St SM 1661, Houston, TX 77030 USA.
C3 Houston Methodist
RP Rupert, P (通讯作者)，Houston Methodist Hosp, Dept Surg, 6550 Fannin St SM 1661, Houston, TX 77030 USA.
EM pkrupert@houstonmethodist.org
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   Zhong SP, 2010, WIRES NANOMED NANOBI, V2, P510, DOI 10.1002/wnan.100
NR 17
TC 14
Z9 17
U1 0
U2 11
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2016
VL 25
IS 4
SU S
BP S17
EP S21
DI 10.12968/jowc.2016.25.Sup4.S17
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DJ2OG
UT WOS:000374043700004
PM 27068343
DA 2026-07-24
ER

PT J
AU Hlinková, E
   Nemcová, J
   Simová, A
   Balková, M
AF Hlinkova, E.
   Nemcova, J.
   Simova, A.
   Balkova, M.
TI The factors of pressure ulcer's in critically ill patients
SO CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
LA English
DT Article
DE pressure ulcer; critically ill; factors of healing; mobility; nutrition
ID INTENSIVE-CARE-UNIT; RISK-ASSESSMENT; INJURY; NUTRITION; WOUNDS
AB Aim: The aim of the study was to identify and analyse the factors influencing the course of healing pressure ulcers in critically ill patients, then compare the variability of the healing in patients after stabilisation. Patients and methods: We chose a comparative multi-case study using qualitative and quantitative research methods as the research strategy. The study sample consisted of three critically ill patients with pressure ulcers. Results: In our study, all patients went to a critical condition after a therapeutic intervention on the heart (cases A, C - cardiac surgery; case B - radiological intervention). The pressure ulcers occurred during controlled and supportive ventilation, continuous intravenous sedation and analgesia. Hypoxia, hernodynamic instability, vasopressors with vasoconstrictive effects, obesity, malnutrition, immobility, inability to change position in controlled and supportive ventilation are factors which do not contribute to the pressure ulcers healing. In case A, healing occurred after verticalization of the patient, by improving the self-care, vitamin C with zinc and adding protein supplements (sipping). After 8 months pressure ulcer was definitely healed. In the case B (coma vigil), 80% of the area of pressure ulcers was healed after introduction to the percutaneous endoscopic gastrostomy (PEG) feeding. In case C, healing was complicated by quadriplegia and malnutrition which did riot improve even by administering vitamins orally, the patient was fed via nasogastric tube. Despite negative pressure wound therapy, healing did not occur. Conclusion: The impact of mobility and nutrition on pressure ulcers healing was significantly confirmed in our study. It has been shown that nasogastric feeding is inadequate compared to PEG (nutritionally defined enteral nutrition).
C1 [Hlinkova, E.; Nemcova, J.] Comenius Univ, Jessenius Fac Med, Dept Nursing, Martin, Slovakia.
   [Simova, A.; Balkova, M.] Univ Hosp Martin, Dept Surg, Martin, Slovakia.
   [Simova, A.; Balkova, M.] Univ Hosp Martin, Transplantat Ctr, Martin, Slovakia.
C3 Comenius University Bratislava
RP Hlinková, E (通讯作者)，Jessenius Fac Med, Dept Nursing, Mala Hora 5, Martin 03601, Slovakia.
EM hlinkova@jfmed.uniba.sk
RI Nemcová, Jana/AAE-5919-2022
OI Nemcová, Jana/0000-0003-4972-2621
FU KEGA [070UK-4/2017]
FX The study was supported by the grant KEGA No. 070UK-4/2017 "The quality
   of nursing care for selected groups of patients".
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NR 26
TC 2
Z9 2
U1 0
U2 18
PU CZECH MEDICAL SOC
PI PRAGUE 2
PA SOKOLSKA 31, PRAGUE 2 120 26, CZECH REPUBLIC
SN 1210-7859
EI 1802-4041
J9 CESK SLOV NEUROL N
JI Cesk. Slov. Neurol. Neurochir.
PY 2018
VL 81
SU 1
BP S13
EP S18
DI 10.14735/amcsnn2018S13
PG 6
WC Neurosciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Surgery
GA HD9FV
UT WOS:000452867800002
DA 2026-07-24
ER

PT J
AU Goudie, EB
   Gendics, C
   Lantis, JC
AF Goudie, Ewan B.
   Gendics, Cynthia
   Lantis, John C., II
TI Multimodal therapy as an algorithm to limb salvage in diabetic patients
   with large heel ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Clinics; Evidence; Infection; Wounds
ID QUALITY-OF-LIFE; PARTIAL CALCANECTOMY; FOOT; ULCERATIONS
AB In many series of diabetic foot ulcer care, heel ulcers greater than 4 cm across have been identified as an independent predictor of limb loss. Therefore, we set out to pursue the most aggressive limb salvage algorithm in patients with heel ulcers greater than 4 cm in diameter. Over 5 years, we identified 21 patients, 3984 years of age, all with diabetes mellitus, with heel ulcers greater than 4 cm in diameter and had magnetic resonance imaging or bone scan evidence of osteomyelitis. Seven of the 21 patients had end-stage renal disease defined as being haemodialysis dependent. All patients had ankle brachial indices <0./4 or monophasic pulse volume recordings. All patients underwent distal bypass surgery with vein. After adequate perfusion was obtained, all patients underwent partial calcanectomy and intra-operative negative pressure wound therapy (NPWT) placement. This was followed by treatment with recombinant platelet-derived growth factor (PDGF). One patient underwent amputation during the healing process secondary to ongoing sepsis. Twenty of 21 patients healed acutely (within 6 months). Three of 20 patients went on to subsequent below knee amputation within 12 months of healing primarily. At 2 years, 12 of 21 (57%) were ambulating independently, 1 of 21 was dead, 4 of 21 had undergone amputation, 4 (19%) had limbs that were intact but were not ambulating. A total limb salvage rate of 76% at 2 years mirrored the secondary patency rates, with 100% follow up. Heel ulcers require multimodality therapy if they are going to have any chance to heal. We believe the algorithm presented allows for the required revascularisation and a modulation of the heel ulcer microenvironment by augmenting the microcirculation through NPWT, and improving the proliferative capacity with PDGF.
C1 [Goudie, Ewan B.] Univ Edinburgh, Dept Orthopead, Edinburgh, Midlothian, Scotland.
   [Gendics, Cynthia; Lantis, John C., II] St Lukes Roosevelt Hosp, Div Vasc Surg, New York, NY USA.
C3 University of Edinburgh; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，St Lukes Roosevelt Hosp, 1090 Amsterdam Ave,Suite 7A, New York, NY 10024 USA.
EM jcl161@columbia.edu
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   [张力伟 Zhang Liwe], 2011, [混凝土, Concrete], P16
NR 27
TC 35
Z9 39
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 132
EP 138
DI 10.1111/j.1742-481X.2011.00869.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900006
PM 21951818
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Boyar, V
AF Boyar, Vita
TI Successful Management of Complex Pediatric and Neonatal Wounds With
   Methylene Blue and Gentian Violet Foam Dressings
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE pediatrics; neonatal wounds; methylene blue and gentian violet foam
   dressings; antimicrobial; debridement
AB Introduction. Topical antimicrobial treatment of wounds in pediatric, and especially neonatal, patients can be challenging due to increased systemic absorption, damaging inflammatory cytokines, and oxygen radicals released by bacterial death. A product combining all wound bed preparation principles is desired. Methylene blue and gentian violet (MB/GV) foam dressings can keep wound beds moist, decrease ongoing inflammation, provide antibacterial coverage, and promote healthy wound edges. Objective. This article examines the use of MB/GV antibacterial foams in pediatric patients. Cases included infants with giant omphalocele epidermal stripping, dehisced abdominal wounds, peristomal dermatitis, and peripheral intravenous extravasations and adolescents with stage 4 pressure injuries. The treatment goals were to optimize the wound bed through debridement, elimination of bioburden, providing moisture balance, and enhancement of granulation tissue growth. Materials and Methods. Eight patients (6 infants and 2 adolescents) received MB/GV foam dressings every 2 to 3 days along with standard of care (SOC) management. Results. Effective debridement, bioburden elimination, moisture balance, and edge enhancement were achieved in all wounds. All wound beds were well-prepared to receive other SOC products as needed. Three cases were considered for negative pressure wound therapy (NPWT), but NPWT was not used because of challenging clinical characteristics and wound locations. Instead, MB/GV polyvinyl alcohol foam provided capillary wicking action that enhanced wound closure without NPWT. No side effects were observed. Conclusions. Methylene blue and gentian violet foam dressings appear to be a safe clinical option for antibacterial coverage, moisture management, and debridement in neonatal and pediatric patients.
C1 [Boyar, Vita] Cohen Childrens Med Ctr, 269-01 76 Ave,New Hyde Pk, Great Neck, NY 11020 USA.
C3 Northwell Health; North Shore University Hospital; Steven & Alexandra
   Cohen Children's Medical Center of New York
RP Boyar, V (通讯作者)，Cohen Childrens Med Ctr, 269-01 76 Ave,New Hyde Pk, Great Neck, NY 11020 USA.
EM Vboyar@northwell.edu
RI Boyar, Vita/J-5657-2019
CR Applewhite Andrew Joseph, 2015, Surg Technol Int, V26, P65
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Bolto B, 2009, PROG POLYM SCI, V34, P969, DOI 10.1016/j.progpolymsci.2009.05.003
   Coutts PM, 2014, ADV SKIN WOUND CARE, V27, DOI 10.1097/01.ASW.0000443270.71030.71
   Edwards K, 2016, ADV WOUND CARE, V5, P11, DOI 10.1089/wound.2014.0593
   Furtado S., 2018, 2021 WOUND CON SUMM
   Hill R, 2017, WOUNDS CAN MAY 12 14
   Lullove EJ, 2017, WOUNDS, V29, P107
   Punjataewakupt A, 2019, EUR J CLIN MICROBIOL, V38, P39, DOI 10.1007/s10096-018-3393-5
   Shi L, 2010, ADV SKIN WOUND CARE, V23, P456, DOI 10.1097/01.ASW.0000383224.64524.ae
   Sibbald RG, 2014, ADV SKIN WOUND CARE, V27, DOI 10.1097/01.ASW.0000443269.63406.f9
   Steen EH, 2020, ADV SKIN WOUND CARE, V33, P294, DOI 10.1097/01.ASW.0000661804.09496.8c
   Woo KY, 2017, INT WOUND J, V14, P1029, DOI 10.1111/iwj.12753
NR 13
TC 3
Z9 3
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2021
VL 33
IS 10
BP 253
EP 259
DI 10.25270/wnds/2021.253259
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WT5DR
UT WOS:000715884700002
PM 34735362
DA 2026-07-24
ER

PT J
AU Roos, E
   Douissard, J
   Abbassi, Z
   Buchs, NC
   Tosoz, C
   Ris, F
   Meyer, J
AF Roos, Elfin
   Douissard, Jonathan
   Abbassi, Ziad
   Buchs, Nicolas C.
   Tosoz, Christian
   Ris, Frederic
   Meyer, Jeremy
TI Prophylactic negative-pressure wound therapy for prevention of surgical
   site infection in abdominal surgery: a nationwide cross-sectional survey
SO UPDATES IN SURGERY
LA English
DT Article
DE Negative therapy; Negative-pressure therapy; PREVENA; PICO
ID ABDOMINOPERINEAL RESECTION; INCISIONAL HERNIA; RECTAL-CANCER;
   RISK-FACTORS; PERINEAL; CLOSURE; IMPACT
AB Our objective was to determine current practice in Switzerland regarding the use of pNPWT in abdominal surgery. An online survey was carried out to evaluate the use of pNPWT among abdominal surgeons in Switzerland. One hundred and ten participants replied to the survey from 16.12.2019 to 15.01.2020. Eleven were excluded, leaving 99 responders for analysis. Seventy participants (70.7%) were using pNPWT, 3 (3%) have stopped using it and 26 (26.3%) have never used it. pNPWT was used on midline laparotomy by 63 responders (90%), closed stoma wounds by 21 (30%), closed perineal wounds by 20 (28.6%), Pfannenstiel incisions by 18 (23.7%), groin incisions by 16 (22.9%), subcostal incisions by 13 (18.6%), Mc Burney incisions by 3 (4.3%) and other incisions by 18 (25.7%). Forty-eight participants (68.6%) used pNPWT on less than 10% of patients, 14 (20%) on 10-25% of patients, six (8.6%) on 25-50% of patients and two (2.9%) on 75-100% of patients. Suggestions for improvement to pNPWT were: better sealing, recyclable system, better adaptation to the perineum, smaller device, reduced cost and possibility to check the surgical wound through the dressing. In conclusion, pNPWT is widely used among Swiss surgeons, mostly on midline incisions. However, most of them apply pNPWT on a small proportion of patients only. Suggestions for improvement were a better sealing for complex wounds, reduced cost and possibility to check the wound during the therapy.
C1 [Roos, Elfin] Karolinska Inst, Dept Global Publ Hlth, S-17177 Stockholm, Sweden.
   [Douissard, Jonathan; Abbassi, Ziad; Buchs, Nicolas C.; Tosoz, Christian; Ris, Frederic; Meyer, Jeremy] Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
   [Douissard, Jonathan; Abbassi, Ziad; Buchs, Nicolas C.; Tosoz, Christian; Ris, Frederic; Meyer, Jeremy] Univ Geneva, Med Sch, CH-1205 Geneva, Switzerland.
   [Roos, Elfin] Linkoping Univ, Cty Council Ostergotland, Linkoping, Sweden.
C3 Karolinska Institutet; University of Geneva; University of Geneva; City
   Council Ostergotland; Linkoping University
RP Meyer, J (通讯作者)，Univ Hosp Geneva, Div Digest Surg, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.; Meyer, J (通讯作者)，Univ Geneva, Med Sch, CH-1205 Geneva, Switzerland.
EM jeremy.meyer@hcuge.ch
RI Douissard, Jonathan/AEJ-4252-2022; Ris, Frederic/H-7030-2019; Meyer,
   Jeremy/AAP-3367-2020; Abbassi, Ziad/HZL-6239-2023
OI Douissard, Jonathan/0000-0002-3931-3157; Ris,
   Frederic/0000-0001-7421-6101; Meyer, Jeremy/0000-0003-3381-9146;
   Abbassi, Ziad/0000-0002-4130-5084
FU Universite de Geneve
FX Open Access funding provided by Universite de Geneve.
CR Allegranzi Benedetta, 2016, Lancet Infect Dis, V16, pe288, DOI 10.1016/S1473-3099(16)30402-9
   Artioukh DY, 2007, COLORECTAL DIS, V9, P362, DOI 10.1111/j.1463-1318.2006.01159.x
   Bullard KM, 2005, DIS COLON RECTUM, V48, P438, DOI 10.1007/s10350-004-0827-1
   Chadi SA, 2014, DIS COLON RECTUM, V57, P999, DOI 10.1097/DCR.0000000000000161
   Chung A, 2014, DIS COLON RECTUM, V57, pE306
   Fischer JP, 2016, ANN SURG, V263, P1010, DOI 10.1097/SLA.0000000000001394
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   Roos E, ANN SURG
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   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Wiatrek Rebecca L, 2008, Clin Colon Rectal Surg, V21, P76, DOI 10.1055/s-2008-1055325
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   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 21
TC 1
Z9 2
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD OCT
PY 2021
VL 73
IS 5
BP 1983
EP 1988
DI 10.1007/s13304-021-01017-3
EA APR 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WE4VW
UT WOS:000638808700001
PM 33837948
OA Green Published, Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lin, YN
   Chuang, CH
   Huang, SH
   Huang, SH
   Lin, TM
   Lin, IW
   Lin, SD
   Kuo, YR
AF Lin, Yun-Nan
   Chuang, Chieh-Han
   Huang, Shih-Hao
   Huang, Shu-Hung
   Lin, Tsai-Ming
   Lin, I-Wen
   Lin, Sin-Daw
   Kuo, Yur-Ren
TI Fat grafting for resurfacing an exposed implant in lower extremity A
   case report
SO MEDICINE
LA English
DT Article
DE fat; implant exposure; lower limb; trauma
ID FREE-TISSUE TRANSFER; STEM-CELLS; CLINICAL-APPLICATIONS; RECONSTRUCTION;
   AUGMENTATION; LIPOASPIRATE; LIPOTRANSFER; DISEASE
AB Rationale: Although numerous reconstruction protocols have been reported for lower leg trauma, those for distal leg trauma remain few. We present the case of a woman with an implant exposure wound, who was successfully treated through fat grafting, without major flap surgery.
   Patient concerns: An 83-year-old woman with an exposed implant in lower extremity received reconstruction surgery once and the surgery failed. She refused additional major surgery and negative pressure wound therapy.
   Diagnoses: The diagnosis of a tibia and fibula shaft open fracture (type IIIA) complicated with an exposed implant was made.
   Interventions: The procedure was performed by deploying purified and emulsified fat with a Micro-Autologous Fat Transplantation gun. The required lipoaspirate amount was grossly estimated using a standard formula: 0.5 cc of a lipoaspirate per square centimeter of wound. We prepared the lipoaspirate simply through centrifugation followed by physical emulsification. The endpoint of fat grafting was when lipoaspirate began to flow out of the wound. The initial dressing after the procedure included the topical usage of biomycin ointment with AQUACEL Foam (ConvaTec Inc., NC, USA) coverage, which was later changed to INTRASITE gel (Smith & Nephew, London, UK) with a gauze dressing for 4 weeks. After 4 weeks, dressing components were changed to Mepilex (Molnlycke Health Care, Gothenburg, Sweden) alone.
   Outcomes: The wound healed completely without requiring major flap surgery by 18 weeks after surgery.
   Lessons: Fat grafting is one kind of cell therapy and potentially has regenerative effects during wound healing. Fat grafting is critical in the healing processes of complicated wounds and might be considered a step in reconstruction surgery.
C1 [Lin, Yun-Nan; Huang, Shu-Hung; Lin, Sin-Daw; Kuo, Yur-Ren] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Lin, Yun-Nan; Chuang, Chieh-Han; Lin, Sin-Daw] Kaohsiung Municipal Siaogang Hosp, Dept Surg, 482 Shanming Rd, Kaohsiung 812, Taiwan.
   [Huang, Shih-Hao] Kaohsiung Municipal Siaogang Hosp, Dept Orthopaed Surg, Kaohsiung, Taiwan.
   [Lin, Tsai-Ming] Charming Inst Aesthet & Regenerat Surg, Kaohsiung, Taiwan.
   [Lin, I-Wen] Kaohsiung Med Univ Hosp, Dept Nursing, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital
RP Lin, YN (通讯作者)，Kaohsiung Municipal Siaogang Hosp, Dept Surg, 482 Shanming Rd, Kaohsiung 812, Taiwan.
EM yunnan1123@gmail.com
RI Huang, Shu-Hung/AAA-3445-2021; Lin, Sin-Daw/D-5504-2009
OI Huang, Shu-Hung/0000-0002-2903-1703; Kuo, Yur-Ren/0000-0002-9388-5009; 
CR Accurso A, 2017, AESTHET PLAST SURG, V41, P36, DOI 10.1007/s00266-016-0739-1
   [Anonymous], PLAST RECONSTR SURG
   Cervelli V, 2011, STEM CELL RES, V6, P103, DOI 10.1016/j.scr.2010.11.003
   Chang HL, 2015, ACCIDENT ANAL PREV, V79, P212, DOI 10.1016/j.aap.2015.03.023
   Engel H, 2011, PLAST RECONSTR SURG, V127, p228S, DOI 10.1097/PRS.0b013e3182008e12
   Gir P, 2012, PLAST RECONSTR SURG, V130, P249, DOI 10.1097/PRS.0b013e318254b4d3
   Gir P, 2012, PLAST RECONSTR SURG, V129, P1277, DOI 10.1097/PRS.0b013e31824ecae6
   Hallock GG, 2013, PLAST RECONSTR SURG, V132, P1733, DOI 10.1097/PRS.0b013e3182a80925
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   Kao WP, 2016, AESTHET SURG J, V36, P648, DOI 10.1093/asj/sjv253
   Kolle SFT, 2013, LANCET, V382, P1113, DOI 10.1016/S0140-6736(13)61410-5
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   Moran SL, 2002, PLAST RECONSTR SURG, V109, P999, DOI 10.1097/00006534-200203000-00031
   Pallua N, 2009, PLAST RECONSTR SURG, V123, P826, DOI 10.1097/PRS.0b013e318199ef31
   Piccolo NS, 2015, CLIN PLAST SURG, V42, P263, DOI 10.1016/j.cps.2014.12.009
   Rigotti G, 2007, PLAST RECONSTR SURG, V119, P1409, DOI 10.1097/01.prs.0000256047.47909.71
   Stasch T, 2015, PLAST RECONSTR SURG, V136, P1357, DOI 10.1097/PRS.0000000000001819
   Sultan SM, 2012, J PLAST RECONSTR AES, V65, P219, DOI 10.1016/j.bjps.2011.08.046
   Tonnard P, 2013, PLAST RECONSTR SURG, V132, P1017, DOI 10.1097/PRS.0b013e31829fe1b0
   Yoshimura K, 2008, AESTHET PLAST SURG, V32, P48, DOI 10.1007/s00266-007-9019-4
NR 21
TC 6
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2017
VL 96
IS 48
AR e8901
DI 10.1097/MD.0000000000008901
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FS2VD
UT WOS:000419636400057
PM 29310377
OA gold
DA 2026-07-24
ER

PT J
AU Schmidt, F
   Mennigen, R
   Vowinkel, T
   Neumann, PA
   Senninger, N
   Palmes, D
   Laukoetter, MG
AF Schmidt, Fabian
   Mennigen, Rudolf
   Vowinkel, Thorsten
   Neumann, Philipp A.
   Senninger, Norbert
   Palmes, Daniel
   Laukoetter, Mike G.
TI Endoscopic Vacuum Therapy (EVT)-a New Concept for Complication
   Management in Bariatric Surgery
SO OBESITY SURGERY
LA English
DT Article
DE Laparoscopic sleeve gastrectomy; Endoscopic vacuum therapy; EVT;
   Negative pressure wound therapy; Bariatric surgery; Obesity; Anastomotic
   leakage; Postoperative complications; Therapeutic endoscopy
ID Y GASTRIC BYPASS; UPPER GASTROINTESTINAL-TRACT; ANASTOMOTIC LEAKAGE;
   SLEEVE GASTRECTOMY; ESOPHAGEAL PERFORATIONS; ASSISTED CLOSURE; STENTS;
   INSUFFICIENCY; METAANALYSIS; MORTALITY
AB Background Bariatric surgery is the most efficient therapy for morbid obesity. Staple line and anastomotic leakage are the most feared postoperative complications after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy (LSG). Traditional treatment options like revisional surgery and endoscopic stent placement are associated with high morbidity and mortality as well as variable success rates. Endoscopic vacuum therapy (EVT) has shown to be a new successful and feasible treatment option for leaks of different etiology after major gastro-esophageal surgery.
   Method We report a case of the EVT principle being applied in a patient with three major leaks located apart from each other within the gastric staple line after LSG for morbid obesity (BMI 62.7). EVT was initiated on postoperative day 8.
   Results In total, 18 endoscopic interventions were performed in 72 days, the vacuum sponge being replaced endoscopically every 4 days. Hospital length of stay was 106 days. No relevant procedure related complications were observed during the course of therapy and during the follow up.
   Conclusion EVT of postoperative leaks in the upper GI tract has been shown to be feasible and safe. It combines defect closure and effective drainage and allows a periodic inspection of the wound cavity. In case of therapeutic failure, it does not jeopardize surgical repair or stent placement. Even though the techniques and materials used in EVT still vary considerably according to local expertise, EVT has the potential to succeed as a nonsurgical, feasible, safe, and effective treatment option for postoperative leaks in bariatric surgery.
C1 [Schmidt, Fabian; Mennigen, Rudolf; Vowinkel, Thorsten; Neumann, Philipp A.; Senninger, Norbert; Palmes, Daniel; Laukoetter, Mike G.] Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
C3 University of Munster
RP Laukoetter, MG (通讯作者)，Univ Hosp Muenster, Dept Gen & Visceral Surg, Albert Schweitzer Campus 1,Bldg W1, D-48149 Munster, Germany.
EM laukoetter@uni-muenster.de
RI Neumann, Philipp-Alexander/AAE-2940-2019
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NR 32
TC 29
Z9 32
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD SEP
PY 2017
VL 27
IS 9
BP 2499
EP 2505
DI 10.1007/s11695-017-2783-6
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FE1IJ
UT WOS:000407971600043
PM 28695459
DA 2026-07-24
ER

PT J
AU Mangiafico, RA
   Mangiafico, M
AF Mangiafico, Roberto A.
   Mangiafico, Marco
TI Medical Treatment of Critical Limb Ischemia: Current State and Future
   Directions
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Critical limb ischemia; peripheral arterial disease; medical treatment;
   atherosclerosis; limb salvage; cardiovascular risk reduction
ID PERIPHERAL ARTERIAL-DISEASE; ENDOTHELIAL PROGENITOR CELLS;
   HYPERBARIC-OXYGEN THERAPY; QUALITY-OF-LIFE; MOLECULAR-WEIGHT HEPARIN;
   INTERMITTENT PNEUMATIC COMPRESSION; ATHEROSCLEROTIC VASCULAR-DISEASE;
   LOWER-EXTREMITY ISCHEMIA; ANKLE BRACHIAL INDEX; CHRONIC FOOT ULCERS
AB Atherosclerotic critical limb ischemia (CLI) is manifested by ischemic rest pain, non-healing ulcers or gangrene. The incidence of CLI is estimated to be approximately 500-1000 new cases per year per million people and is expected to grow in developed countries as the population ages with an increasing prevalence of diabetes. Patients diagnosed with CLI are at very high risk of major amputation and cardiovascular morbidity and mortality and experience poor physical function and quality of life. The goals of treatment for CLI are relieving ischemic pain, healing ulcers, preventing limb loss, improving patient function and quality of life, and prolonging survival. Prompt surgical or endovascular revascularization is currently recommended for limb salvage in CLI. All patients with CLI should receive cardiovascular risk reduction therapies, focused on optimizing antiplatelet therapy and risk factor management, to reduce cardiovascular event rates. Adjunctive pharmacotherapy with antithrombotic drugs, statins, and beta-blockers is critical to decrease perioperative cardiovascular complications in patients undergoing surgical vascular reconstruction and enhance post-revascularization arterial and graft patency. In non-reconstructable patients with stable pain and tissue loss, evidence suggests that prostanoids, dedicated wound care programs, and several mechanical devices, such as spinal cord stimulation, intermittent pneumatic compression, and hyperbaric oxygen therapy, can alleviate ischemic symptoms and improve limb salvage. Current medical armamentarium used in treating ischemic wounds also includes ultrasound and negative pressure wound therapy. Therapeutic neovascularization, including gene-and cell-based approaches, is a novel promising tool in the management of CLI under ongoing investigation.
C1 [Mangiafico, Roberto A.; Mangiafico, Marco] Univ Catania, Dept Internal Med, I-95124 Catania, Italy.
C3 University of Catania
RP Mangiafico, RA (通讯作者)，Univ Catania, Dept Internal Med, Via Plebiscito 628, I-95124 Catania, Italy.
EM rmangiafico@alice.it
RI Mangiafico, Marco/KBQ-6031-2024
OI Mangiafico, Marco/0009-0005-1196-9073; Mangiafico,
   Marco/0009-0005-1196-9073
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NR 251
TC 24
Z9 30
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD NOV
PY 2011
VL 9
IS 6
BP 658
EP 676
PG 19
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 882KL
UT WOS:000299562400002
PM 21595626
DA 2026-07-24
ER

PT J
AU Ak, AA
   Agrawal, V
   Dwivedi, S
   Pandey, M
   Tripathy, GN
   Taleja, H
   Anand, S
   Chandran, D
AF Anto Ak, Ajin
   Agrawal, Vivek
   Dwivedi, Surjeet
   Pandey, Mohneesh
   Tripathy, G. N.
   Taleja, Hitesh
   Anand, S.
   Chandran, Dinoy
TI Analgesic Effect and Safety of Topical Sevoflurane During
   Dressing/Debridement of Chronic Painful Ulcer: Original Article
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Sevoflurane; Analgesia; Visual analogue score; Negative pressure wound
   therapy; Split skin grafting
ID CHRONIC VENOUS ULCERS
AB Painful ulcers have shown high economic and epidemiologic impacts. This is a novel study to assess the analgesic effectiveness and safety of topical sevoflurane during the debridement of a painful ulcer. This study is a prospective observational study that includes 100 patients above the age of 20 years, with chronically infected ulcers (more than 4 weeks) associated with pain (baseline visual analog scale (VAS) score > 8) of various etiologies requiring dressing/debridement. Debridement was done with IV analgesic drugs only or both IV analgesia and topical sevoflurane on alternative dressing as a crossover design. Group 1 (odd day) underwent IV analgesic alone-Injection Paracetamol 1 g IV, and Group 2 (even day) underwent IV analgesic + topical sevoflurane-Injection Paracetamol 1 g IV + sevoflurane topically applied. Dose of sevoflurane-1 mL/1 cm(2) of ulcer area. The gauze piece was soaked with sevoflurane and kept over the ulcer for 7-10 min before starting the dressing/debridement. The patient was kept blinded, and the VAS score was recorded every time. The mean age was 66 +/- 12 years, with female patients on the higher side. The etiology includes 38% arterial ulcers, 35% venous ulcers, and the rest traumatic ulcers. There was a significant reduction in the mean VAS scores during subsequent dressings. This novel study group had a dominant of elderly patients who were suffering from chronic ulcers. Sevoflurane was found to be beneficial in managing pain in these patients. Its use in the elderly population is particularly promising due to its potential to alleviate patients suffering from chronic ulcers. This study opens up new possibilities for utilizing sevoflurane in pain management beyond its traditional use in anesthesia.
C1 [Anto Ak, Ajin; Anand, S.] Command Hosp Air Force, Dept Surg, Bangalore, India.
   [Agrawal, Vivek] Command Hosp AF, Dept Vasc Surg, Bangalore, India.
   [Dwivedi, Surjeet; Chandran, Dinoy] AFMC, Dept Surg, Pune, Maharashtra, India.
   [Pandey, Mohneesh; Tripathy, G. N.; Taleja, Hitesh] 92 Base Hosp, Dept Surg, Srinagar, India.
C3 Armed Forces Medical College
RP Ak, AA (通讯作者)，Command Hosp Air Force, Dept Surg, Bangalore, India.
EM ajinanto@gmail.com; viveksadhnaom@gmail.com; surjeetdwivedi@gmail.com;
   mohneeshpandey22@gmail.com; girijanandantripathy@gmail.com;
   hitesh5287@gmail.com; anandvijay422@gmail.com; drdinoyr@gmail.com
OI AK, Ajin Anto/0000-0001-6271-4349
CR Fernández-Ginés FD, 2020, INT WOUND J, V17, P83, DOI 10.1111/iwj.13235
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NR 15
TC 0
Z9 0
U1 0
U2 5
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD FEB
PY 2026
VL 88
IS 1
BP 123
EP 128
DI 10.1007/s12262-025-04358-0
EA APR 2025
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DP4HL
UT WOS:001476832500001
DA 2026-07-24
ER

PT J
AU Dixon, JE
   Wellington, V
   Elnima, A
   Savers, A
   Ferreras, LAB
   Jalal, AR
   Eltaher, HM
AF Dixon, James E.
   Wellington, Vanessa
   Elnima, Alaa
   Savers, Amelie
   Ferreras, Lia A. Blokpoel
   Jalal, Aveen R.
   Eltaher, Hoda M.
TI Enhanced localized pressure-mediated non-viral gene delivery
SO DRUG DELIVERY AND TRANSLATIONAL RESEARCH
LA English
DT Article
DE GAG-binding <underline>e</underline>nhanced
   <underline>t</underline>ransduction (GET); Negative pressure wound
   therapy; Gene transfer; Transfection; Skin
ID CELL-PENETRATING PEPTIDES; PORE-SIZE; IN-VITRO; THERAPY; PROTEIN;
   TRANSDUCTION; FORMULATION; CHALLENGES; SCAFFOLDS; DNA
AB Topically applied therapies must not only be effective at the molecular level but also efficiently access the target site which can be on milli/centimetre-scales. This bottleneck is particularly inhibitory for peptide and nucleic acid macromolecule drug delivery strategies, especially when aiming to target wounded, infected, and poorly perfused tissues of significant volume and geometry. Methods to drive fluid-flow or to enhance physical distribution of such formulations after local administration in accessible tissues (skin, eye, intestine) would be transformative in realizing the potential of such therapeutics. We previously developed a technology termed Glycosaminoglycan (GAG)-binding enhanced transduction (GET) to efficiently deliver a variety of cargoes intracellularly, using GAG-binding peptides and cell penetrating peptides (CPPs) in the form of nanoparticles. Herein, we demonstrate that the most simplistic GET formulation is relatively poor in diffusing into tissue matrix (tested in collagen scaffolds). Changing nanoparticle physicochemical properties can enhance penetration, however the use of a pressure differential, generating fluid-flow significantly enhances effective gene delivery over milli/centimetre scales. We adapted clinically used pressure systems to administer both negative (Negative pressure (NP) wound therapy; NPWT) and positive pressures (PP; Insufflator). Pressure differences generated enhanced distribution, and we were able to show for the first-time localized gene transfer in vitro in cell scaffolds and enhanced transfection of ex vivo skin explants. The ability to simply control intra-tissue localization of gene delivery on milli/centimetre scales using pressure application will facilitate new drug delivery strategies for accessible tissues. Importantly site-specific enhancement of penetration and activity of novel nanotechnologies and gene therapeutics could be transformative for future regenerative medicine strategies.
C1 [Dixon, James E.; Wellington, Vanessa; Elnima, Alaa; Savers, Amelie; Ferreras, Lia A. Blokpoel; Jalal, Aveen R.; Eltaher, Hoda M.] Univ Nottingham, Biodiscovery Inst BDI, Sch Pharm, Regenerat Med & Cellular Therapies Div, Nottingham NG7 2RD, England.
   [Dixon, James E.] Univ Nottingham, NIHR Nottingham Biomed Res Ctr, Nottingham NG7 2RD, England.
C3 University of Nottingham; University of Nottingham
RP Dixon, JE (通讯作者)，Univ Nottingham, Biodiscovery Inst BDI, Sch Pharm, Regenerat Med & Cellular Therapies Div, Nottingham NG7 2RD, England.; Dixon, JE (通讯作者)，Univ Nottingham, NIHR Nottingham Biomed Res Ctr, Nottingham NG7 2RD, England.
EM james.dixon@nottingham.ac.uk
RI M. Eltaher, Hoda/AAO-6116-2020
OI M. Eltaher, Hoda/0000-0001-5602-2696; Dixon, James/0000-0003-1225-3825
FU Defence Science and Technology Laboratory
FX Not applicable
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NR 60
TC 0
Z9 0
U1 2
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2190-393X
EI 2190-3948
J9 DRUG DELIV TRANSL RE
JI Drug Deliv. Transl. Res.
PD OCT
PY 2025
VL 15
IS 10
BP 3679
EP 3694
DI 10.1007/s13346-025-01827-7
EA MAR 2025
PG 16
WC Instruments & Instrumentation; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Instruments & Instrumentation; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 7CV1L
UT WOS:001442993200001
PM 40072728
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Yellin, JI
   Gaebler, JA
   Zhou, FF
   Niecko, T
   Novins, O
   Ockert, A
   Krzynowek, D
   Garoufalis, MG
   Lee, ALZM
   Frykberg, RG
AF Yellin, Jessica Izhakoff
   Gaebler, Julia A.
   Zhou, Frank F.
   Niecko, Timothy
   Novins, Olivia
   Ockert, Amelia
   Krzynowek, Darcy
   Garoufalis, Matthew G.
   Lee, Aliza M.
   Frykberg, Robert G.
TI Reduced Hospitalizations and Amputations in Patients with Diabetic Foot
   Ulcers Treated with Cyclical Pressurized Topical Wound Oxygen Therapy:
   Real-World Outcomes
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE diabetic foot ulcers; topical oxygen therapy; amputations;
   hospitalizations
ID DOUBLE-BLIND; LOWER-LIMB; MULTICENTER; MANAGEMENT; VETERANS; PRIVATE;
   BURDEN
AB Background: This study sought to examine the real-world impact of multimodality cyclical-pressure topical wound oxygen therapy (TWO2) on hospitalizations and amputations in patients with diabetic foot ulcer (DFU) compared with patients without TWO2.Methods: We conducted a retrospective review of deidentified patient medical records at 2 U.S. Veterans Affairs hospitals between January 2012 and January 2020. DFU patients were assigned to TWO2 or NO TWO2 cohorts based on their treatment records. Patients received appropriate standard of care and may have received other advanced wound treatments, including skin substitutes, negative pressure wound therapy, and growth factors. Primary study outcomes were patients requiring hospitalization and/or amputation within 360 days of initial wound documentation.Findings: Among unmatched cohorts of 202 patients with DFU (91 TWO2, 111 NO TWO2), 6.6% and 12.1% of TWO2 patients had hospitalizations and amputations, respectively, compared with 54.1% and 41.4% of NO TWO2 patients within 360 days (p < 0.0001, p < 0.0001), representing 88% and 71% reductions. Among propensity score-matched cohorts of 140 DFU patients (70 TWO2, 70 NO TWO2), compared with NO TWO2, 82% fewer TWO2 patients were hospitalized (7.1% vs. 40.0%, p < 0.0001) and 73% fewer TWO2 patients had amputations (8.6% vs. 31.4%, p = 0.0007). Logistic regression among matched cohorts demonstrated nearly ninefold and fivefold higher risk of hospitalization and amputation, respectively, for NO TWO2 versus TWO2.Interpretation: This retrospective cohort study demonstrates that treating patients with DFU with TWO2 is associated with significant reductions in hospitalizations and amputations in the real-world setting.
C1 [Yellin, Jessica Izhakoff; Gaebler, Julia A.; Zhou, Frank F.; Novins, Olivia; Ockert, Amelia; Krzynowek, Darcy] Hlth Adv LLC, Newton, MA USA.
   [Niecko, Timothy] Niecko Hlth Econom LLC, Tierra Verde, FL USA.
   [Garoufalis, Matthew G.] Jesse Brown VA Med Ctr, Dept Podiatry, Chicago, IL USA.
   [Lee, Aliza M.] Salem Vet Affairs Med Ctr, Dept Podiatry, Salem, VA USA.
   [Frykberg, Robert G.] Midwestern Univ, Diabet Foot Consultants, Dept Podiatry, Glendale, AZ USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Jesse Brown VA Medical Center; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Salem Veterans Affairs Medical
   Center; Midwestern University; Midwestern University - Glendale
RP Frykberg, RG (通讯作者)，Midwestern Univ, Diabet Foot Consultants, Dept Podiatry, Glendale, AZ USA.; Frykberg, RG (通讯作者)，Diabet Foot Consultants, Dept Podiatry, 15411 N Tepic Lane, Fountain Hills, AZ 85268 USA.
EM rgfdpm@diabeticfoot.net
OI Frykberg, Robert/0000-0001-9095-303X; Zhou, Frank
   Feng/0000-0001-6953-7322
FU AOTI Ltd. (Galway, Ireland); AOTI
FX The authors would like to thank Despi Herodo-tou (Director of Clinical
   Development, AOTI) for her help with data collection. This study was
   sponsored by AOTI Ltd. (Galway, Ireland). Health Advances received
   consultative reimbursement from AOTI, and T.N. received consultative
   reimbursement from Health Advances for his independent performance of
   the statistical analysis. R.G.F. has received research funding from and
   is a consultant for AOTI. M.G.G. has received research funding and is a
   consultant for AOTI. A.M.L. has received research funding from AOTI
CR Aldana PC, 2020, AM J CLIN DERMATOL, V21, P255, DOI 10.1007/s40257-019-00495-x
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NR 30
TC 21
Z9 24
U1 3
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD DEC 1
PY 2022
VL 11
IS 12
BP 657
EP 665
DI 10.1089/wound.2021.0118
EA DEC 2021
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6P3HW
UT WOS:000727190100001
PM 34714167
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Kachala, SS
   D'Souza, DM
   Teixeira-Johnson, L
   Murthy, SC
   Raja, S
   Blackstone, EH
   Raymond, DP
AF Kachala, Stefan S.
   D'Souza, Desmond M.
   Teixeira-Johnson, Lucileia
   Murthy, Sudish C.
   Raja, Siva
   Blackstone, Eugene H.
   Raymond, Daniel P.
TI Surgical Management of Sternoclavicular Joint Infections
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID ARTHRITIS
AB Background. Infections of the sternoclavicular joint (SCJ) respond poorly to nonoperative management and typically require resection. We examined presenting characteristics and outcomes after surgical management of SCJ infections, reviewing a 20-year single-institution experience.
   Methods. From January 1992 to December 2012, 40 patients (age, 57 +/- 12 years; 70% male) underwent resection of an infected SCJ. Sternal infections after cardiac surgery were excluded. Clinical features, microbiology, recurrence, survival, and functional impairment were assessed. Infection was documented by the surgeon, and supported by tissue culture. Clinical presentation and treatment course were obtained by review of medical records. The functional assessment was determined by phone interviews using the validated QuickDASH outcome measure. Mortality data were gathered from the medical record.
   Results. Pain was the presenting symptom in 93% of patients. Staphylococcal species were isolated in 73% of tissue specimens. Fifteen patients (37%) underwent primary closure and 25 patients (63%) underwent closure by secondary intention with application of negative-pressure wound therapy. There were four recurrences (10%), one after primary closure and three in the secondary intention group. No deaths occurred within 30 days of operation, and 5-year survival was 67%. Functional assessment using the QuickDASH outcome measure revealed minimal loss in upper extremity function after the procedure (preoperative score, 10 +/- 3; postoperative score, 19 +/- 6.8; n = 11). There was no difference in functional outcome comparing primary closure versus secondary intention (19 +/- 4.4 versus 20 +/- 8.2; p = 0.64).
   Conclusions. Septic arthritis of the SCJ is routinely managed surgically at many centers. We report that primary closure with a muscle flap can achieve similar outcomes to secondary intention in selected patients. Furthermore, patients experienced minimal functional impairment at long-term follow-up. (C) 2016 by The Society of Thoracic Surgeons
C1 Cleveland Clin, Thorac & Cardiovasc Surg, Cleveland, OH 44195 USA.
   Cleveland Clin, Dept Infect Dis, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Raymond, DP (通讯作者)，Cleveland Clin, Mail Code J4-1,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM raymond3@ccf.org
OI Blackstone, Eugene/0000-0001-9839-3567; D'Souza, Desmond
   M/0000-0002-7342-3464
CR [Anonymous], 2011, The DASH and QuickDASH Outcome Measure Users Manual
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NR 12
TC 32
Z9 41
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD JUN
PY 2016
VL 101
IS 6
BP 2155
EP 2160
DI 10.1016/j.athoracsur.2016.01.054
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DM6ZW
UT WOS:000376502600024
PM 27083249
OA Bronze
DA 2026-07-24
ER

PT J
AU Abu-Khudir, R
   Doghish, AS
   Mansour, RM
   Sayed, GA
   Elshami, NH
   Moustafa, HAM
   Elkalla, WS
   Abdulkader, AO
   Mageed, SSA
   Mohammed, OA
   Hamad, RS
   Abulsoud, AI
   Zaki, MB
   Elrebehy, MA
   Abdelfatah, AM
   Salah, AN
AF Abu-Khudir, Rasha
   Doghish, Ahmed S.
   Mansour, Reda M.
   Sayed, Ghadir A.
   Elshami, Nourhan H.
   Moustafa, Hebatallah Ahmed Mohamed
   Elkalla, Wagiha S.
   Abdulkader, Ahmed O.
   Mageed, Sherif S. Abdel
   Mohammed, Osama A.
   Hamad, Rabab S.
   Abulsoud, Ahmed I.
   Zaki, Mohamed Bakr
   Elrebehy, Mahmoud A.
   Abdelfatah, Amr M.
   Salah, Akram N.
TI Infection control and wound care innovations in plastic surgery: a
   multidisciplinary approach
SO FOLIA MICROBIOLOGICA
LA English
DT Review
DE Plastic surgery; Wound healing; Postoperative complication; Wound
   infection; Postoperative infections
ID SURGICAL SITE INFECTIONS; ANTIBIOTIC-PROPHYLAXIS; NOSOCOMIAL INFECTIONS;
   MICROBIOLOGY; MANAGEMENT; OUTCOMES; SKIN; METAANALYSIS; ASSOCIATION;
   PREVENTION
AB An infection that develops after plastic or reconstructive surgery is one of the most common and difficult consequences to deal with. In addition to compromising functional recovery and cosmetic outcomes, these infections can greatly lengthen hospital stays, raise patient morbidity, and slow wound healing. Infection risk in plastic surgery is complex and multifaceted, necessitating an all-encompassing and preventative strategy. Strict aseptic surgical procedures, perioperative antibiotic prophylaxis based on procedure type and patient risk profile, and comprehensive preoperative skin preparation to decrease microbial load are important preventive strategies. Significantly less infection risk can be achieved with patient optimization prior to surgery by controlling comorbidities like diabetes, correcting dietary deficiencies, stopping smoking, and managing immunosuppressive conditions. New approaches to wound care have emerged that promise to speed up the healing process while simultaneously decreasing the incidence of infections. Some of these methods include using antimicrobial dressings that release silver or iodine over time, using negative pressure wound therapy to increase blood flow and drain excess fluid, and utilizing bioengineered scaffolds and matrices rich in growth factors to stimulate cell proliferation and angiogenesis. Preventing deep tissue involvement and surgical site infection requires early diagnosis of infection signals and rapid action. The purpose of this review is to highlight current evidence-based methods and advances in the field of plastic surgery that aim to reduce infections and enhance wound healing. It also emphasizes the significance of an integrated, multidisciplinary approach in order to improve both the functional and aesthetic outcomes of surgical procedures.
C1 [Abu-Khudir, Rasha] King Faisal Univ, Coll Sci, Dept Chem, POB 380, Al Hasa 31982, Hofuf, Saudi Arabia.
   [Doghish, Ahmed S.] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr 11231, Cairo, Egypt.
   [Doghish, Ahmed S.] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr 11829, Cairo, Egypt.
   [Mansour, Reda M.] Badr Univ Cairo, Sch Biotechnol, Mol Biol & Biotechnol Dept, Badr City 11829, Cairo, Egypt.
   [Mansour, Reda M.] Helwan Univ, Fac Sci, Zool & Entomol Dept, Helwan 11795, Egypt.
   [Sayed, Ghadir A.] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
   [Elshami, Nourhan H.] Ain Shams Univ, Fac Pharm, Dept Microbiol & Immunol, Org African Unity St, Abbasiya 11566, Cairo, Egypt.
   [Moustafa, Hebatallah Ahmed Mohamed] Badr Univ Cairo BUC, Fac Pharm, Dept Clin Pharm & Pharm Practice, Badr 11829, Cairo, Egypt.
   [Elkalla, Wagiha S.; Abdulkader, Ahmed O.; Salah, Akram N.] Badr Univ Cairo BUC, Fac Pharm, Microbiol & Immunol Dept, Badr 11829, Cairo, Egypt.
   [Mageed, Sherif S. Abdel] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Badr 11829, Cairo, Egypt.
   [Mohammed, Osama A.] Univ Bisha, Coll Med, Dept Pharmacol, Bisha 61922, Saudi Arabia.
   [Hamad, Rabab S.] King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa 31982, Saudi Arabia.
   [Abulsoud, Ahmed I.] Heliopolis Univ, Fac Pharm, Integrat Hlth Ctr, Cairo 11785, Egypt.
   [Abulsoud, Ahmed I.] Al Azhar Univ, Fac Pharm Boys, Nasr 11231, Cairo, Egypt.
   [Zaki, Mohamed Bakr] Univ Sadat City, Fac Pharm, Dept Biochem, Sadat 32897, Egypt.
   [Zaki, Mohamed Bakr] Menoufia Natl Univ, Fac Pharm, Dept Biochem, km Cairo Alexandria Agr Rd, Menoufia, Egypt.
   [Elrebehy, Mahmoud A.] Galala Univ, Fac Pharm, Dept Biochem, New Galala 43713, Suez, Egypt.
   [Abdelfatah, Amr M.] Badr Univ Cairo, Fac Pharm, Dept Pharmaceut Analyt Chem, Badr 11829, Cairo, Egypt.
C3 King Faisal University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Badr University in Cairo; Badr University in Cairo; Egyptian
   Knowledge Bank (EKB); Capital University - Egypt; Egyptian Russian
   University; Egyptian Knowledge Bank (EKB); Ain Shams University; Badr
   University in Cairo; Badr University in Cairo; Badr University in Cairo;
   University of Bisha; King Faisal University; Egyptian Knowledge Bank
   (EKB); Heliopolis University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Egyptian Knowledge Bank (EKB); University of Sadat City;
   Galala University; Badr University in Cairo
RP Abu-Khudir, R (通讯作者)，King Faisal Univ, Coll Sci, Dept Chem, POB 380, Al Hasa 31982, Hofuf, Saudi Arabia.; Doghish, AS (通讯作者)，Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr 11231, Cairo, Egypt.; Doghish, AS (通讯作者)，Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr 11829, Cairo, Egypt.
EM rabukhudir@kfu.edu.sa; ahmed_doghish@azhar.edu.eg
RI Hamad, Rabab/H-9104-2016; Moustafa, hebatallah/NXX-9279-2025; mansour,
   reda/ACW-5693-2022; Elrebehy, Mahmoud/LZF-1181-2025; Soliman Doghish,
   Ahmed/AAB-4004-2021; Abulsoud, Ahmed/Y-1116-2018; Abu-Khudir,
   Rasha/JHT-1566-2023; sabry, sherif/HPF-9803-2023; Bakr,
   Mohamed/HGA-5685-2022; Bastawesy, Ghadir/IWM-6990-2023; Mohammed, Osama
   A/IRZ-5046-2023
OI Moustafa, hebatallah/0000-0003-4530-406X; Soliman Doghish,
   Ahmed/0000-0002-0136-7096; Mohammed, Osama A/0000-0001-9712-9609;
   Elshami, Nourhan H/0009-0006-2401-4660
FU Deanship of Scientific Research, Vice Presidency for Graduate Studies
   and Scientific Research, King Faisal University, Saudi Arabia
   [KFU253706]
FX This work was supported by the Deanship of Scientific Research, Vice
   Presidency for Graduate Studies and Scientific Research, King Faisal
   University, Saudi Arabia [Grant No. KFU253706].
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NR 117
TC 1
Z9 1
U1 4
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0015-5632
EI 1874-9356
J9 FOLIA MICROBIOL
JI Folia Microbiol.
PD APR
PY 2026
VL 71
IS 2
BP 215
EP 234
DI 10.1007/s12223-025-01373-2
EA NOV 2025
PG 20
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA HX5IP
UT WOS:001616647100001
PM 41252064
DA 2026-07-24
ER

PT J
AU Holbert, MD
   Wood, F
   Holland, AJA
   Teague, W
   Kimble, RM
   Crellin, D
   Frear, CC
   Storey, K
   Phillips, N
   Singer, Y
   Dimanopoulos, TA
   Martin, L
   Cuttle, L
   Vagenas, D
   Mcphail, SM
   Calleja, P
   Duff, J
   De Young, A
   Griffin, BR
AF Holbert, Maleea D.
   Wood, Fiona
   Holland, Andrew J. A.
   Teague, Warwick
   Kimble, Roy M.
   Crellin, Dianne
   Frear, Cody C.
   Storey, Kristen
   Phillips, Natalie
   Singer, Yvonne
   Dimanopoulos, Tanesha A.
   Martin, Lisa
   Cuttle, Leila
   Vagenas, Dimitrios
   Mcphail, Steven M.
   Calleja, Pauline
   Duff, Jed
   De Young, Alexandra
   Griffin, Bronwyn R.
TI Implementation of negative pressure for acute pediatric burns (INPREP):
   A stepped-wedge cluster randomized controlled trial protocol
SO PLOS ONE
LA English
DT Article
ID WOUND THERAPY; SUBATMOSPHERIC PRESSURE; OPTIMAL DURATION; HEALING TIME;
   PROGRESSION; MANAGEMENT; DRESSINGS; CORTISOL; SCARS
AB Background Acute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy. The Implementation of Negative PRessurE for acute Pediatric burns (INPREP) trial will implement and evaluate the impact of adjunctive NPWT in parallel with co-designed implementation strategies and resources across four major pediatric hospitals.Methods We will conduct a multi-center, prospective, stepped-wedge cluster randomized controlled trial to implement adjunctive NPWT for acute pediatric burns. Participants will include pediatric burn patients presenting to one of four Australian tertiary pediatric hospitals for burn treatment. The intervention is adjunctive NPWT in parallel with co-designed and tailored implementation strategies and a suite of NPWT implementation resources, which form the INPREP toolkit. Using a hybrid type III design, this trial aims to evaluate the effectiveness of NPWT implementation in parallel with the INPREP toolkit using (i) implementation outcomes (e.g., adoption, appropriateness, acceptability, feasibility, and sustainability) and (ii) clinical outcomes (e.g., days to re-epithelialization, scar management requirements, skin grafting requirements). The primary outcome of this trial is treatment adoption-the proportion of eligible patients who receive NPWT.Discussion This manuscript outlines a protocol for a hybrid type III stepped-wedge cluster randomized controlled trial of adjunctive NPWT implementation in acute pediatric burn care. We anticipate that NPWT implementation in parallel with the INPREP toolkit will be generalizable to emergency departments and burn services across Australia, and evidence generated will inform pediatric burn care internationally.Trial registration Australian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022.
C1 [Holbert, Maleea D.; Storey, Kristen; Singer, Yvonne; Dimanopoulos, Tanesha A.; Griffin, Bronwyn R.] Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, South Brisbane, Qld, Australia.
   [Holbert, Maleea D.; Kimble, Roy M.; Frear, Cody C.; Storey, Kristen; Phillips, Natalie; Dimanopoulos, Tanesha A.; De Young, Alexandra; Griffin, Bronwyn R.] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
   [Wood, Fiona; Martin, Lisa] Perth Childrens Hosp, Nedlands, WA, Australia.
   [Wood, Fiona; Martin, Lisa] Univ Western Australia, Burn Injury Res Unit, Crawley, WA, Australia.
   [Holland, Andrew J. A.] Childrens Hosp Westmead, Burns Unit, Westmead, NSW, Australia.
   [Holland, Andrew J. A.] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Sydney, NSW, Australia.
   [Teague, Warwick] Murdoch Childrens Res Inst, Surg Res, Parkville, Vic, Australia.
   [Teague, Warwick; Crellin, Dianne] Royal Childrens Hosp Melbourne, Clin Psychol Serv, Parkville, Vic, Australia.
   [Teague, Warwick; Crellin, Dianne] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia.
   [Teague, Warwick] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Kimble, Roy M.; Frear, Cody C.] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Crellin, Dianne] Univ Melbourne, Dept Nursing, Parkville, Vic, Australia.
   [Phillips, Natalie] Univ Queensland, Child Hlth Res Ctr, South Brisbane, Qld, Australia.
   [Cuttle, Leila] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, Brisbane, Australia.
   [Vagenas, Dimitrios] Queensland Univ Technol, Fac Hlth, Sch Publ Hlth & Social Work, Brisbane, Australia.
   [Mcphail, Steven M.] Queensland Univ Technol, Australian Ctr Hlth Serv Innovat, Sch Publ Hlth & Social Work, Ctr Healthcare Transformat,Fac Hlth, Brisbane, Kelvin Grove, Australia.
   [Mcphail, Steven M.] Queensland Univ Technol, Ctr Healthcare Transformat, Sch Publ Hlth & Social Work, Brisbane, Kelvin Grove, Australia.
   [Calleja, Pauline] James Cook Univ, Coll Healthcare Sci, Cairns, Australia.
   [Duff, Jed] Queensland Univ Technol, Fac Hlth, Ctr Healthcare Transformat, Brisbane, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Perth Childrens Hospital; University of Western Australia; NSW
   Health; Sydney Childrens Hospitals Network; The Children's Hospital at
   Westmead; University of Sydney; University of Sydney; Murdoch Children's
   Research Institute; Royal Children's Hospital Melbourne; University of
   Melbourne; Monash University; University of Queensland; University of
   Melbourne; University of Queensland; Queensland University of Technology
   (QUT); Queensland University of Technology (QUT); Queensland University
   of Technology (QUT); Queensland University of Technology (QUT); James
   Cook University; Queensland University of Technology (QUT)
RP Holbert, MD (通讯作者)，Griffith Univ, Sch Nursing & Midwifery, Nathan Campus, South Brisbane, Qld, Australia.; Holbert, MD (通讯作者)，Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
EM m.holbert@griffith.edu.au
RI De Young, Alex/D-9093-2019; McPhail, Steven/JMR-2141-2023; Phillips,
   Natalie/LBI-7045-2024; Griffin, Bronwyn/AEB-6299-2022; Teague,
   Warwick/AAY-7260-2020; Calleja, Pauline/AAE-7981-2020; Holland,
   Andrew/N-5547-2017; Singer, Yvonne/LEN-2822-2024; Cuttle,
   Leila/C-5223-2008; Kimble, Roy/B-4160-2011; fiona, wood/F-4703-2013;
   Duff, Jed/AAV-9927-2020
OI Martin, Lisa Joanne/0000-0001-8947-834X; McPhail,
   Steven/0000-0002-1463-662X; Holbert, Maleea/0000-0002-9902-5122;
   Griffin, Bronwyn/0000-0002-6182-9125; Teague,
   Warwick/0000-0003-4747-6025; Calleja, Pauline/0000-0001-5674-1404;
   Holland, Andrew/0000-0003-3745-8704; Singer, Yvonne/0000-0001-6225-5891;
   fiona, wood/0000-0001-5427-6588; Duff, Jed/0000-0003-1427-0303
FU National Health and Medical Research Council Partnership Projects
   [2006970]; National Health and Medical Research Council (NHMRC)
   [2006970] Funding Source: National Health and Medical Research Council
   (NHMRC)
FX National Health and Medical Research Council Partnership Projects [PRC2
   Funding ID: 2006970] The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 69
TC 1
Z9 1
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 10
PY 2024
VL 19
IS 12
AR e0315278
DI 10.1371/journal.pone.0315278
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P1F0N
UT WOS:001375443900018
PM 39656723
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Mueller, KB
   D'Antuono, M
   Patel, N
   Pivazyan, G
   Aulisi, EF
   Evans, KK
   Nair, MN
AF Mueller, Kyle B.
   D'Antuono, Matthew
   Patel, Nirali
   Pivazyan, Gnel
   Aulisi, Edward F.
   Evans, Karen K.
   Nair, M. Nathan
TI Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound
   Dressing on the Development of Surgical Site Infection after Spinal
   Surgery: A Prospective Observational Study
SO NEUROSURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Southern-Neurosurgical-Society
CY FEB 28, 2020
CL Scottsdale, AZ
SP S0 Neurosurg Soc
DE Surgical site infection; Negative pressure therapy; Spine surgery; Wound
   healing
ID HIGH-RISK; PREVENTION; MANAGEMENT; NPWT; COMPLICATIONS; FRACTURES;
   NUTRITION; FUSION; IMPACT
AB BACKGROUND: Use of a closed-incisional negative pressure therapy (ci-NPT) dressing is an emerging strategy to reduce surgical site infections (SSIs) in spine surgery that lacks robust data.
   OBJECTIVE: To determine the impact of a ci-NPT, as compared with a standard dressing, on the development of SSIs after spine surgery.
   METHODS: This was a prospective observational study over a 2-yr period. Indications for surgery included degenerative disease, deformity, malignancy, and trauma. Exclusion criteria included anterior and lateral approaches to the spine, intraoperative durotomy, or use of minimally invasive techniques. SSIs up to 60 d following surgery were recorded.
   RESULTS: A total of 274 patients were included. SSI rate was significantly lower with ci-NPT dressing (n = 118) as compared with the standard dressing (n = 156) (3.4 vs 10.9%, P = .02). There was no statistical difference in infection rate for decompression alone procedures (4.2 vs 9.1%, P = .63), but there was a statistically significant reduction with the use of a negative-pressure dressing in cases that required instrumentation (3.2 vs 11.4%, P = .03). Patients at higher risk (instrumentation, deformity, and malignancy) had less SSIs with the use of ci-NPT, although this did not reach statistical significance. There were no complications in either group.
   CONCLUSION: SSI rates were significantly reduced with a ci-NPT dressing vs a standard dressing in patients who underwent spinal surgery. The higher cost of a ci-NPT dressing might be justified with instrumented cases, as well as with certain high-risk patient populations undergoing spine surgery, given the serious consequences of an infection.
C1 [Mueller, Kyle B.; Patel, Nirali; Pivazyan, Gnel; Nair, M. Nathan] Georgetown Univ, Dept Neurosurg, Med Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
   [D'Antuono, Matthew] Georgetown Univ, Sch Med, Washington, DC 20007 USA.
   [Aulisi, Edward F.] MedStar Washington Hosp Ctr, Dept Neurosurg, Washington, DC USA.
   [Evans, Karen K.] Georgetown Univ, Dept Plast Surg, Med Ctr, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University; MedStar Washington
   Hospital Center; Georgetown University
RP Mueller, KB (通讯作者)，Georgetown Univ, Dept Neurosurg, Med Ctr, 3800 Reservoir Rd NW, Washington, DC 20007 USA.
EM kyle.mueller85@gmail.com
RI Mueller, Kyle/HSI-4288-2023; Pivayzan, Gnel/JJF-1220-2023; D'Antuono,
   Matthew/AAD-5725-2020
OI D'Antuono, Matthew/0000-0002-1837-7004
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NR 51
TC 35
Z9 41
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-396X
EI 1524-4040
J9 NEUROSURGERY
JI Neurosurgery
PD MAY
PY 2021
VL 88
IS 5
BP E445
EP E451
DI 10.1093/neuros/nyab040
EA FEB 2021
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Surgery
GA RQ5EQ
UT WOS:000642441000019
PM 33611587
DA 2026-07-24
ER

PT J
AU Chow, SE
   Chen, CPC
   Hsu, CC
   Tsai, WC
   Wang, JS
   Hsu, NC
AF Chow, Shu-Er
   Chen, Carl Pai-Chu
   Hsu, Chih-Chin
   Tsai, Wen-Chung
   Wang, Jong-Shyan
   Hsu, Ning-Chun
TI Quantifying cell behaviors in negative-pressure induced monolayer cell
   movement
SO BIOMEDICAL JOURNAL
LA English
DT Article
DE Cell movement; Cytoskeleton; Intercellular junctions; Negative-pressure
   wound therapy; Wound healing
ID WOUND FIBRIN MATRIX; HYPERBARIC-OXYGEN; MIGRATION; PROLIFERATION;
   MECHANISMS; THERAPY; MODEL
AB Background: Negative-pressure of 125 mmHg (NP) has been shown to accelerate wound healing. Effects of NP on human keratinocyte behaviors during wound healing process were highlighted in this study.
   Methods: An NP incubator incorporating the electric cell-substrate impedance sensing (ECIS) technique has been built to quantify monolayer keratinocytes movement in serum-free media at the ambient pressure (AP) and NP for 12 h. Monolayer cell motions were continuously recorded by ECIS in the frequency range of 22.5-64 kHz. Membrane capacitance (C-m), cell-substratum resistance (alpha), and cell-cell junction resistance (R-b) were evaluated in cells at the different pressures.
   Results: A greater monolayer cell migration distance was found in cells at NP. Decreased cell-substratum adhesion reflected in the significantly low alpha (AP:NP = similar to 5 Omega(0.5):similar to 3 Omega(0.5), cm), decreased integrin expression, and increased cell-substratum distance were seen in cells at NP. A significantly increased C-m (AP:NP = similar to 4:similar to 8 mu F/cm(2)) in association with increased membrane ruffling and microtubule filaments were observed early in the monolayer cell movement at NP. A progressive drop in the R-b from 1.2 Omega.cm(2) to 0.8 Omega.cm(2) corresponding to the gradually decreased E-cadherin expressions were observed 6 h after wound closure after NP treatment.
   Conclusion: A quick membrane ruffling formation, an early cell-substratum separation, and an ensuing decrease in the cellular interaction occur in cells at NP. These specific monolayer cell behaviors at NP have been quantified and possibly accelerate wound healing.
C1 [Chow, Shu-Er] Chang Gung Univ, Ctr Gen Studies, Dept Nat Sci, Taoyuan, Taiwan.
   [Chen, Carl Pai-Chu] Chang Gung Mem Hosp Taipei, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Hsu, Chih-Chin; Hsu, Ning-Chun] Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, 222 Maijin Rd, Keelung, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Tsai, Wen-Chung] Chang Gung Mem Hosp Linkou, Dept Phys Med & Rehabil, Taoyuan, Taiwan.
   [Wang, Jong-Shyan] Chang Gung Univ, Coll Med, Inst Rehabil Sci, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University
RP Hsu, CC (通讯作者)，Chang Gung Mem Hosp Keelung, Dept Phys Med & Rehabil, 222 Maijin Rd, Keelung, Taiwan.
EM steele0618@gmail.com
OI Wang, Jong-Shyan/0000-0002-3095-9357
FU Chang Gung Medical Research Program [CMRPG2A0361, CMRPG2B0471,
   CMRPG2D0031, CMRPG2C0381]; National Science Council
   [NSC100-2314-B-182-053-MY3]
FX We thank the Chang Gung Medical Research Program grants (CMRPG2A0361,
   CMRPG2B0471, CMRPG2D0031, and CMRPG2C0381) and our National Science
   Council grant (NSC100-2314-B-182-053-MY3) for support of our academic
   research. We also appreciate the excellent confocal microscopic images
   provided by Mr. Hsiao-Tung Liu in Laser Scanning Confocal Microscopic
   Room, Chang Gung Memorial Hospital, Keelung. Chun-Min Lo in Department
   of Biomedical Engineering, National Yang-Ming University, Taipei, has
   help us process the electrical wound healing assay data.
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NR 28
TC 9
Z9 11
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD FEB
PY 2016
VL 39
IS 1
BP 50
EP 59
DI 10.1016/j.bj.2015.08.005
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA DS3VK
UT WOS:000380710600006
PM 27105598
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hauge, T
   Dretvik, T
   Johnson, E
   Mala, T
AF Hauge, Tobias
   Dretvik, Thomas
   Johnson, Egil
   Mala, Tom
TI Treatment of anastomotic leakage following Ivor Lewis esophagectomy-10
   year experience from a Nordic center
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leakage; bronchial fistula; esophagectomy; negative-pressure
   wound therapy; stent
ID RISK-FACTORS; COMPLICATIONS; CONSENSUS; IMPACT
AB Anastomotic leakage (AL) is a dreaded complication following esophageal resection. No clear consensus exist for the optimal handling of this severe complication. The aim of this study was to describe the treatment outcome following AL. We conducted a retrospective cross-sectional study including all patients with AL operated with Ivor Lewis esophagectomy from 2010 to 2021 at Oslo University Hospital, Norway. 74/526 (14%) patients had AL. Patient outcomes were analyzed and categorized according to main AL treatment strategy; stent (54%), endoscopic vacuum therapy and stent (EVT + stent) (19%), nasogastric tube and antibiotics (conservative) (16%), EVT (8%) and by other endoscopic means (other) (3%). One patient had surgical debridement of the chest cavity. In 66 patients (89%), the perforation healed after median 27 (range: 4-174) days. Airway fistulation was observed in 11 patients (15%). Leak severity (ECCG) was associated with development of airway fistula (P = 0.03). The median hospital and intensive care unit stays were 30 (range: 12-285) and 9 (range: 0-60) days. The 90-days mortality among patients with AL was 5% and at follow up, 13% of all deaths were related to AL. AL closure rates were comparable across the groups, but longer in the EVT + stent group (55 days vs. 29.5 days, P = 0.04). Thirty-two percent developed a symptomatic anastomotic stricture within 12 months. Conclusion: The majority of AL can be treated endoscopically with preservation of the conduit and the anastomosis. We observed a high number of AL-associated airway fistulas.
C1 [Hauge, Tobias; Dretvik, Thomas; Johnson, Egil; Mala, Tom] Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, Ulleval, Norway.
   [Johnson, Egil; Mala, Tom] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Hauge, Tobias] Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, POB 4956, N-0424 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Hauge, T (通讯作者)，Oslo Univ Hosp, Dept Pediat & Gastrointestinal Surg, POB 4956, N-0424 Oslo, Norway.
EM tobiha@ous-hf.no
RI Mala, Tom/J-5418-2019
OI Mala, Tom/0000-0003-3058-4775
CR Bartella I, 2023, LANGENBECK ARCH SURG, V408, DOI 10.1007/s00423-023-03001-4
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NR 25
TC 7
Z9 7
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAY 14
PY 2024
VL 37
IS 9
DI 10.1093/dote/doae040
EA MAY 2024
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA E0Q0O
UT WOS:001222279800001
PM 38745429
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Dua, A
   Ahmad, N
   Dove, CR
   Regulski, MJ
   Rose-Sauld, S
   Garoufalis, MG
AF Dua, Anahita
   Ahmad, Naseer
   Dove, Cyaandi R.
   Regulski, Matthew J.
   Rose-Sauld, Sara
   Garoufalis, Matthew G.
TI TWO2 Therapy Demonstrates Clinically Meaningful Long-Term
   Outcomes Compared to Other Advanced Wound Care Modalities: Real-World
   Evidence Supported by Mechanistic and RCT Clinical Data
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE chronic wounds; topical oxygen therapy; intermittent compression;
   multi-modality intermittent topical oxygen therapy (ITOT); inflammation
   resolution; wound healing; advanced wound care; cyclical pressurized
   topical wound oxygen (TWO2)
ID DIABETIC FOOT ULCERS; CONVENTIONAL COMPRESSION DRESSINGS; TOPICAL
   OXYGEN-THERAPY; VENOUS ULCERS; MANAGEMENT; BURDEN
AB Background/Objectives: Chronic diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) remain a major source of morbidity, healthcare utilization, and limb loss, despite adherence to established standards of care protocols and the widespread availability of advanced wound technologies. Many advanced modalities only target isolated aspects of wound healing and fail to address the complex, interdependent pathophysiology of chronic wounds, particularly tissue hypoxia, edema, impaired microcirculation, and persistent inflammation. Cyclical Pressurized Topical Wound Oxygen (TWO2) therapy is a home-based, multimodal intervention that combines humidified topical oxygen delivery with cyclical non-contact compression to address these core drivers simultaneously. Methods: This review synthesizes mechanistic rationale and evidence from randomized controlled trials, long-term venous ulcer studies, and real-world comparative effectiveness analyses. Emphasis is placed on the large cohort study by Yellin et al., which directly compared TWO2 with other advanced modalities including negative pressure wound therapy (NPWT), skin substitutes, and growth factor therapies. Results: Across these studies, TWO2 therapy is consistently associated with improved healing durability, reduced recurrence, and substantial reductions in hospitalization and amputation rates compared with both standard care and advanced wound therapies. Conclusions: The convergence of randomized and real-world evidence supports TWO2 therapy as a clinically meaningful and mechanism-driven adjunctive treatment option for patients with chronic, high-risk lower-extremity wounds.
C1 [Dua, Anahita] Harvard Med Sch, Massachusetts Gen Hosp, Div Vasc & Endovasc Surg, Boston, MA 02114 USA.
   [Ahmad, Naseer] Manchester Vasc Ctr, Dept Vasc Surg, Manchester M13 9WL, England.
   [Dove, Cyaandi R.] Oregon Hlth & Sci Univ, Dept Endocrinol Diabet & Clin Nutr, Portland, OR 97239 USA.
   [Dove, Cyaandi R.] Oregon Hlth & Sci Univ, Harold Schnitzer Diabet Hlth Ctr, Portland, OR 97239 USA.
   [Regulski, Matthew J.] Ocean Cty Foot & Ankle Surg Associates PC, Forked River, NJ 08753 USA.
   [Rose-Sauld, Sara] Massachusetts Gen Hosp, Dept Orthoped Surg, Div Podiatry, Boston, MA 02114 USA.
   [Garoufalis, Matthew G.] Western Univ Hlth Sci, Dept Podiatr Med & Surg, Pomona, CA 91766 USA.
   [Garoufalis, Matthew G.] Profess Foot Care Specialists, Chicago, IL 60632 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Oregon Health & Science
   University; Oregon Health & Science University; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Western University of Health Sciences
RP Garoufalis, MG (通讯作者)，Western Univ Hlth Sci, Dept Podiatr Med & Surg, Pomona, CA 91766 USA.; Garoufalis, MG (通讯作者)，Profess Foot Care Specialists, Chicago, IL 60632 USA.
EM mggaro@aol.com
FX This research received no external funding.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 19
PY 2026
VL 15
IS 12
AR 4780
DI 10.3390/jcm15124780
EA JUN 2026
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KC9RT
UT WOS:001804005800001
PM 42355948
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Travers, HI
   Kuznetsov, M
   Mazzocco, J
   Pagani, N
   Ide, T
   Hollenbeck, BL
   Smith, EL
AF Travers, Hannah I.
   Kuznetsov, Mikhail
   Mazzocco, John
   Pagani, Nicholas
   Ide, Tricia
   Hollenbeck, Brian L.
   Smith, Eric L.
TI Musculoskeletal Quality Collaborative Improves Value-Based Health Care
   Delivery Across Hospital System
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID PRESSURE WOUND THERAPY; KNEE ARTHROPLASTY; TOTAL HIP; INFECTION;
   OUTCOMES
AB Objectives: Rising health care costs necessitate value-based health care (VBHC) initiatives. Large hospital systems offer a platform for surgeon collaboration in developing standardized, interdisciplinary orthopedic care. This study evaluates the formation, implementation, and outcomes of the Musculoskeletal Quality Collaborative (MSKQC) across a hospital system. Methods: Established in 2019, the MSKQC comprises physician, quality, and nursing leaders from 14 hospitals. Using the Delphi method, surgeons identified VBHC interventions, leading to protocols for antibiotic-infused bone cement (AIBC), povidone-iodine irrigation, and negative pressure wound therapy (NPWT) dressings, implemented in May 2023. Usage was tracked across hospitals and reviewed quarterly from June 2023 to June 2024. Total hip arthroplasty and total knee arthroplasty (TKA) standardized infection ratios (SIRs) were calculated using National Healthcare Safety Network (NHSN) baselines. Surgeons performing more than 30 cases annually with more than 30% utilization of a target consumable were deemed high utilizers. Results: The systemwide savings opportunity exceeded $800,000 annually. AIBC use dropped from 19.6% to 5.5%. Two high-use hospitals showed gradual improvement, and 7 high-use surgeons were identified. NPWT usage remained stable at less than 5%. Sterile iodine irrigation decreased by 51.6% to less than 10%. TKA infections occurred in 18 of 6592 (0.27%) surgeries in 2023, compared with 14 of 5955 (0.24%) in 2022. The NHSN SIR was 0.906. Conclusions: The MSKQC successfully reduced high-cost consumable use while maintaining low infection rates. Regular protocol distribution and surgeon-specific feedback proved effective in advancing VBHC initiatives. This model offers a scalable approach for orthopedic VBHC implementation in the absence of national guidelines.
C1 [Travers, Hannah I.; Kuznetsov, Mikhail; Pagani, Nicholas; Ide, Tricia; Hollenbeck, Brian L.; Smith, Eric L.] New England Baptist Hosp, 125 Parker Hill Ave, Boston, MA 02120 USA.
   [Mazzocco, John] Tufts Med Ctr, Boston, MA USA.
C3 New England Baptist Hospital; Tufts Medical Center
RP Travers, HI (通讯作者)，New England Baptist Hosp, 125 Parker Hill Ave, Boston, MA 02120 USA.
EM htravers@nebh.org
CR Ailaney N, 2021, J ARTHROPLASTY, V36, P2402, DOI 10.1016/j.arth.2020.11.039
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD JUN
PY 2026
VL 32
IS 6
SI SI
BP SP269
EP SP275
PG 7
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA JY8AU
UT WOS:001801185300001
PM 42258248
DA 2026-07-24
ER

PT J
AU Vinokurov, I
   Khaydukov, E
   Lev, G
   Yusupov, S
   Senchukova, M
AF Vinokurov, Ivan
   Khaydukov, Evgeny
   Lev, Gela
   Yusupov, Said
   Senchukova, Marina
TI Successful photodynamic therapy for infectious complications of
   abdominoplasty using mesh implants: a case report
SO PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
LA English
DT Article
DE Abdominoplasty; Deep sternal wound infection; Surgical site infection;
   TRAM flap; Implant infection; Photodynamic therapy
ID STAPHYLOCOCCUS-AUREUS; HERNIA; MANAGEMENT; BULGE
AB IntroductionInfectious complications of abdominoplasty with mesh implants often require implant removal. Here, we demonstrate for the first time the unique capabilities of photodynamic therapy (PDT) for the treatment of a purulent complication of abdominoplasty with a mesh implant.Case presentationWe report a 44-year-old female patient who underwent reconstruction of a chest wall defect with a transverse rectus abdominis myocutaneous flap and abdominoplasty of the abdominal wall with a mesh implant after treatment for a recurrent deep sternal infection. The postoperative period was complicated by postoperative wound suppuration with implant protrusion. Wound drainage, negative pressure wound therapy and antibacterial therapy were ineffective. The patient was included in a clinical trial on the use of PDT for wound treatment. Five PDT sessions were performed. A riboflavin mononucleotide solution was used as a photosensitizer, which was irrigated on the wound, and after a 2-min pause, the PDT session began. A light source with a wavelength of 450 nm and a power of 0.1 W/cm2 was used for irradiation. The session was carried out until the energy reached 15 J/cm2. On the fifth day, the wound was completely cleaned and sutured with secondary sutures. It healed without any peculiarities. During the control examination after 10 months, no recurrence of the implant infection was observed.ConclusionThese results demonstrate the possibility of using the PDT method for the treatment of infected wounds with mesh implants, which is especially important in the context of increasing the antibiotic resistance of pathogenic strains of microorganisms.
C1 [Vinokurov, Ivan; Khaydukov, Evgeny; Lev, Gela; Yusupov, Said; Senchukova, Marina] Petrovsky Natl Res Ctr Surg, Sci & Clin Ctr 3, Moscow, Russia.
   [Khaydukov, Evgeny] D Mendeleev Univ Chem Technol Russia, Moscow, Russia.
C3 Petrovsky National Research Centre of Surgery; Mendeleev University of
   Chemical Technology of Russia
RP Senchukova, M (通讯作者)，Petrovsky Natl Res Ctr Surg, Sci & Clin Ctr 3, Moscow, Russia.
EM docvin.med@gmail.com; khaydukov@mail.ru; Dr.levgv@gmail.com;
   Patik_417525@mail.ru; masenchukova@yandex.com
RI Senchukova, Marina/W-6584-2018; Lev, Gela/JUU-5752-2023; Lev,
   Gela/JUU-5752-2023; Khaydukov, Evgeny/A-8039-2014
OI Senchukova, Marina/0000-0001-8371-740X; Saidmurod,
   Yusupov/0009-0000-5912-3249; Lev, Gela/0000-0002-4109-2605; Vinokurov,
   Ivan/0000-0003-0433-2523; 
CR Birolini C, 2015, HERNIA, V19, P239, DOI 10.1007/s10029-014-1225-9
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NR 41
TC 0
Z9 0
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1474-905X
EI 1474-9092
J9 PHOTOCH PHOTOBIO SCI
JI Photochem. Photobiol. Sci.
PD JUL
PY 2025
VL 24
IS 7
BP 1223
EP 1228
DI 10.1007/s43630-025-00757-0
EA JUL 2025
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Chemistry
GA 4WW6Z
UT WOS:001524549500001
PM 40627248
DA 2026-07-24
ER

PT J
AU Zhang, LZ
   Michihata, N
   Matsui, H
   Fushimi, K
   Yasunaga, H
   Tsuda, Y
   Tanaka, S
   Kobayashi, H
AF Zhang, Liuzhe
   Michihata, Nobuaki
   Matsui, Hiroki
   Fushimi, Kiyohide
   Yasunaga, Hideo
   Tsuda, Yusuke
   Tanaka, Sakae
   Kobayashi, Hiroshi
TI Preoperative arterial embolization and wound complications after
   resection of malignant bone tumor in the pelvis: a nationwide database
   study
SO JAPANESE JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
DE hemipelvectomy; pelvic sarcoma; deep infection; DPC database
ID INTERNAL ILIAC ARTERY; INFECTION; TRAUMA; RISK; STATISTICS; PREDICTORS;
   NECROSIS; FRACTURE; REGISTRY; SARCOMA
AB This nationwide database study suggested that preoperative arterial embolization could be a risk factor for wound complications following pelvic malignant tumor surgery.
   Background Massive intraoperative blood loss is common in pelvic malignant bone tumor surgery, and preoperative arterial embolization may be used in selected cases. Preoperative arterial embolization reportedly increases wound complications in pelvic fracture surgery, but little evidence is available regarding pelvic bone tumor surgery. Methods Using a Japanese nationwide database (Diagnosis Procedure Combination database), we searched for patients who underwent pelvic malignant bone tumor surgery between July 2010 and March 2018. The primary endpoint was wound complications, defined as any wound requiring re-operation, negative pressure wound therapy or both. Univariate analyses (the chi-squared test for categorical variables, the unpaired t-test for continuous variables) and multivariate logistic regression analyses were performed to examine the association between preoperative arterial embolization and wound complications. Results Among the 266 eligible patients, 43 (16%, 43/266) underwent embolization and 69 (26%, 69/266) developed wound complications. In the univariate analyses, preoperative arterial embolization (P < 0.001), duration of anesthesia (P < 0.001), the volume of blood transfusion (P < 0.001) and duration of indwelling drain tube (P < 0.001) were associated with wound complications. In the multivariate logistic regression analysis, preoperative arterial embolization was significantly associated with wound complications (odds ratio, 3.92; 95% confidence interval, 1.80-8.56; P = 0.001). Conclusions Preoperative arterial embolization may be associated with increased wound complications after pelvic malignant tumor surgery.
C1 [Zhang, Liuzhe; Tsuda, Yusuke; Tanaka, Sakae; Kobayashi, Hiroshi] Univ Tokyo, Dept Orthoped Surg, Tokyo, Japan.
   [Michihata, Nobuaki] Univ Tokyo, Grad Sch Med, Dept Hlth Serv Res, Tokyo, Japan.
   [Matsui, Hiroki; Yasunaga, Hideo] Univ Tokyo, Sch Publ Hlth, Dept Clin Epidemiol & Hlth Econ, Tokyo, Japan.
   [Fushimi, Kiyohide] Tokyo Med & Dent Univ, Grad Sch, Dept Hlth Policy & Informat, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo; Institute
   of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Kobayashi, H (通讯作者)，Univ Tokyo, Fac Med, Dept Orthopaed Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM hkobayashi-tky@umin.ac.jp
RI ; Tsuda, Yusuke/AAE-4741-2022; Matsui, Hirotoshi/LJK-3566-2024;
   Michihata, Nobuaki/AGH-8292-2022
OI Zhang, Liuzhe/0000-0003-0656-2365; 
FU Grants-in-Aid for Scientific Research [21K16648] Funding Source: KAKEN
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NR 30
TC 3
Z9 5
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0368-2811
EI 1465-3621
J9 JPN J CLIN ONCOL
JI Jpn. J. Clin. Oncol.
PD OCT 6
PY 2022
VL 52
IS 10
BP 1176
EP 1182
DI 10.1093/jjco/hyac100
EA JUL 2022
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5D3MB
UT WOS:000822985700001
PM 35818346
DA 2026-07-24
ER

PT J
AU Neas, ED
   Dunn, JA
   Silva, ED
   Chambers, AM
   Luckasen, GJ
   Jaskowiak, A
AF Neas, Edwin D.
   Dunn, Julie A.
   Silva, Evelyn Dimaano
   Chambers, A. Morgan
   Luckasen, Gary J.
   Jaskowiak, Adam
TI Peroxy Pyruvic Acid-Containing Topical Anti-Infective: A Potential
   Candidate for a Wound Instillation Solution
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE peroxy-pyruvic acid; PPA; wound instillation; topical anti-infective;
   chronic wound; microbial biofilm
ID STAPHYLOCOCCUS-SIMULANS; CLINICAL-SIGNIFICANCE; SERRATIA-MARCESCENS;
   BACILLUS-CEREUS; INFECTIONS; SUSCEPTIBILITY; PATHOGEN; CARE; MORGANELLA;
   COMMUNITY
AB Objective: Evaluate the therapeutic properties of a peroxy pyruvic acid (PPA)-containing topical anti-infective in a human ex-vivo model that replicates the natural conditions of a human chronic wound. Approach: Wound material was extracted from patients with nonhealing diabetic ulcers, venous stasis ulcers, and arterial wounds. Microbial species were identified, and wound colonization was quantified. Extracted samples were then exposed to a PPA-containing topical anti-infective as an instillation solution with negative pressure wound therapy NPWT at concentrations of 1,000, 1,500, or 2,500ppm for a period of 1, 5, or 10min to determine the effect of exposure on isolated pathogens, including effect on proteins. Results: A total of 32 samples were collected from patients. Samples presented with a range of bacteria and fungi representing 14 genera and 22 species, many of which are or are evolving to be resistant to many, if not most, current systemic antibiotics. Thirteen of twenty-three samples (57%) from chronic wounds had bacteria counts 10(5) and most were 6logs or more. Seven of 10 samples (70%) from acute wounds had bacteria counts 10(5) and most were much lower. Exposure to PPA-containing topical anti-infective at 1,000ppm killed all bacteria and fungi in all samples within 1min of exposure. Innovation: PPA-containing topical anti-infective is a potentially valuable clinical option for NPWT. Conclusion: PPA-containing topical anti-infective is a potential candidate for use as an NPWT instillation solution for the treatment of wound infections caused by susceptible pathogens.
C1 [Neas, Edwin D.; Silva, Evelyn Dimaano; Chambers, A. Morgan] CHD Biosci Inc, 2950 East Harmony Rd,Suite 252, Ft Collins, CO 80528 USA.
   [Dunn, Julie A.] UC Hlth, Medial Ctr Rockies, Loveland, CO USA.
   [Luckasen, Gary J.; Jaskowiak, Adam] UC Hlth Res, Med Ctr Rockies, Loveland, CO USA.
RP Neas, ED (通讯作者)，CHD Biosci Inc, 2950 East Harmony Rd,Suite 252, Ft Collins, CO 80528 USA.
EM ed.neas@chdbioscience.com
FU CHD Bioscience, Inc.; Acelity
FX The authors gratefully acknowledge Brian G. Bass for editorial
   assistance in the preparation of this article. Funding for the
   preparation of this article was provided by CHD Bioscience, Inc. The
   preclinical study was co-funded with Acelity.
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NR 51
TC 2
Z9 3
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD OCT
PY 2016
VL 5
IS 10
BP 432
EP 443
DI 10.1089/wound.2015.0682
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DZ9SP
UT WOS:000386219400002
PM 27785377
DA 2026-07-24
ER

PT J
AU Mihaljevic, AL
   Schirren, R
   Müller, TC
   Kehl, V
   Friess, H
   Kleeff, J
AF Mihaljevic, Andre L.
   Schirren, Rebekka
   Mueller, Tara C.
   Kehl, Victoria
   Friess, Helmut
   Kleeff, Joerg
TI Postoperative negative-pressure incision therapy following open
   colorectal surgery (Poniy): study protocol for a randomized controlled
   trial
SO TRIALS
LA English
DT Article
DE Abdominal dressing; Colorectal surgery; Negative-pressure wound therapy;
   Randomized trial; Surgical site infection; Wound edge protector; Wound
   infection
ID SURGICAL-SITE INFECTIONS; WOUND EDGE PROTECTION; MANAGEMENT-SYSTEM;
   HOSPITAL STAY; PROPHYLAXIS; MULTICENTER; PREVENTION; CEFOTETAN;
   CLASSIFICATION; COMPLICATIONS
AB Background: Postoperative surgical site infections cause substantial morbidity, prolonged hospitalization, costs and even mortality, and remain one of the most frequent surgical complications. In prospective trials with adequate follow-up, more than 20 % of patients undergoing elective colorectal surgery are affected and methods to reduce surgical site infections are urgently needed. Negative-pressure incision therapy is a novel intervention that holds promise to reduce postoperative wound infection rates, but has not yet been rigorously tested in a randomized controlled trial.
   Methods/Design: The aim is to investigate whether the postoperative application of a negative-pressure incision therapy device for 5-7 days reduces the rate of surgical site infections following open elective colorectal surgery by 50 %. This is a randomized, controlled, observer-blinded multicentre clinical trial with two parallel study groups. The primary outcome measure will be the rate of surgical site infections within 30 days postoperatively. Surgical site infections are defined according to criteria of the US Centers for Disease Control and Prevention. Statistical analysis of the primary endpoint measure will be based on the intention-to-treat population. The global level of significance is set at 5 % (two-sided) and the sample size (n = 170 per group) is determined to assure a power of 80 %.
   Discussion: The Poniy trial will explore whether the rate of surgical site infections can be reduced by the application of a negative-pressure incision therapy device in patients undergoing open elective colorectal surgery. Its pragmatic design guarantees high external validity and clinical relevance.
C1 [Mihaljevic, Andre L.; Schirren, Rebekka; Mueller, Tara C.; Friess, Helmut; Kleeff, Joerg] Tech Univ Munich, Klinikum Rechts Isar, Dept Surg, D-81675 Munich, Germany.
   [Mihaljevic, Andre L.; Schirren, Rebekka; Mueller, Tara C.; Friess, Helmut; Kleeff, Joerg] CHIR Net Munich, D-81675 Munich, Germany.
   [Kehl, Victoria] Tech Univ Munich, Klinikum Rechts Isar, Inst Med Stat & Epidemiol, D-81675 Munich, Germany.
   [Kleeff, Joerg] Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Gen Visceral & Pediat Surg, D-40225 Dusseldorf, Germany.
C3 Technical University of Munich; Technical University of Munich; Heinrich
   Heine University Dusseldorf; Heinrich Heine University Dusseldorf
   Hospital
RP Kleeff, J (通讯作者)，Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Prescot St, Liverpool L7 8XP, Merseyside, England.
EM kleeff@tum.de
RI Friess, Helmut/ABO-1348-2022; Mueller, Tara/AAE-6774-2022; Kleeff,
   Jorg/B-2124-2009
OI Mihaljevic, André/0000-0003-1902-657X; Kleeff, Jorg/0000-0003-3432-6669
FU KCI Inc. (San Antonio, TX, USA)
FX The NPIT devices in the intervention group (Prevena Incision Management
   System) are provided by KCI Inc., Wiesbaden, Germany. Furthermore,
   financial support to cover costs for data management, monitoring and
   trial coordination are provided by KCI Inc. (San Antonio, TX, USA).
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   World Medical Association, 2013, 64 WMA GEN ASS
NR 44
TC 18
Z9 21
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 19
PY 2015
VL 16
AR 471
DI 10.1186/s13063-015-0995-4
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CT7QU
UT WOS:000363010400002
PM 26482031
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Efe, S
   Ates, C
   Cengizhan, MS
   Hanci, P
   Inal, V
AF Efe, Serdar
   Ates, Coskun
   Cengizhan, Mehmet Serdar
   Hanci, Pervin
   Inal, Volkan
TI Alternating pressure air mattresses in the intensive care unit as a
   cost-effective strategy for preventing stage III-IV pressure injuries: a
   retrospective cohort study
SO CLINICS
LA English
DT Article
DE Pressure ulcer prevention; Alternating pressure air mattress;
   Cost-Effectiveness; ICU; NNT
ID RISK-FACTORS; ULCER DEVELOPMENT
AB Background: Pressure Injuries (PIs) are frequent, preventable complications in Intensive Care Units (ICUs), leading to morbidity, mortality, and increased healthcare costs. Alternating Pressure Air Mattresses (APAMs) have been proposed to reduce PI incidence, but real-world data remain scarce. Objectives: To assess the effectiveness and cost-efficiency of APAMs in preventing PIs among critically ill patients. Methods: This retrospective cohort study was conducted in a 10-bed tertiary ICU, comparing patients before and after APAM implementation. Multivariate logistic regression identified independent PI risk factors, and a costeffectiveness model was developed using Number Needed to Treat (NNT) and treatment costs. Results: APAM use reduced overall PI risk by 33% (RR = 0.67; 95% CI 0.45-0.98) and Stage III-IV ulcer risk by 84% (RR = 0.16; 95% CI 0.05-0.53). The NNT was 23, corresponding to net savings of USD 121,750 over five years for a 10-bed ICU, with cost recovery achieved within 4.3-months. Length of Stay (LOS) and prolonged mechanical ventilation independently increased PI risk by 19% and 13% per day, respectively. APAMs' benefit was attenuated in patients with extended LOS and ventilation. Sepsis and respiratory failure increased PI risk in univariate analysis but lost significance after adjustment, indicating mediation by LOS and ventilation. APAMs eliminated the need for negative pressure wound therapy in this cohort. Conclusions: APAMs significantly reduced severe PI incidence and treatment requirements in critically ill patients, demonstrating cost-effectiveness. Their protective effect was limited in patients with prolonged ICU stay or ventilation. Multicenter randomized trials are warranted, especially in diabetic and septic populations.
C1 [Efe, Serdar] Uludag Univ, Fac Med, Dept Intens Care Med, Bursa, Turkiye.
   [Ates, Coskun] Corlu City Hosp, Dept Endocrinol Clin, Tekirdag, Turkiye.
   [Cengizhan, Mehmet Serdar] Tarsus State Hosp, Dept Intens Care Med, Mersin, Turkiye.
   [Hanci, Pervin] Trakya Univ, Dept Pulmonol, Div Intens Care Med, Fac Med, Edirne, Turkiye.
   [Inal, Volkan] Trakya Univ, Fac Med, Dept Internal Med, Div Intens Care Med, Edirne, Turkiye.
C3 Uludag University; Trakya University; Trakya University
RP Efe, S (通讯作者)，Uludag Univ, Fac Med, Dept Intens Care Med, Bursa, Turkiye.
EM serdarefe@uludag.edu.tr
RI Hanci, Pervin/ABA-2695-2022; Efe, Serdar/JAN-4839-2023; inal,
   volkan/A-6069-2018
OI ATEŞ, COŞKUN/0000-0003-4565-9848
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NR 19
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PD JAN-DEC
PY 2026
VL 81
AR 100877
DI 10.1016/j.clinsp.2026.100877
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EY2IF
UT WOS:001712577200001
PM 41795415
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Berjaoui, N
   Santos, F
   Curti, F
   Chan, PS
   Lampridis, S
   Patel, A
   Bille, A
AF Berjaoui, Nabih
   Santos, Felix
   Curti, Fabiana
   Chan, Puiyee Sophia
   Lampridis, Savvas
   Patel, Akshay
   Bille, Andrea
TI Surgical management of complex mediastinitis: an 8-year single-centre
   experience reinforcing the role of open thoracotomy
SO INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE mediastinitis; surgery; thoracotomy; video-assisted thoracoscopic
   surgery; VATS
ID DESCENDING NECROTIZING MEDIASTINITIS; ESOPHAGECTOMY
AB OBJECTIVES Mediastinitis is an infection affecting the mediastinum, often caused by cardiovascular or thoracic surgery procedures. Management entails antibiotic therapy, surgical debridement, drainage of infected sites and immediate or delayed closure. Negative pressure wound therapy is useful in cases of delayed sternal closure. Several approaches for mediastinal drainage have been proposed, but there is no consensus on the thoracic intervention approach.METHODS A single-centre, retrospective analysis from the UK analysed data from 19 patients who underwent surgical management for mediastinitis between September 2015 and April 2023. Our primary aim was to describe the outcomes from our series where we predominantly employed an open surgical approach.RESULTS The mean age of our cohort was 49 +/- 17.12 years old; the mean performance status (PS ECOG) was 2 +/- 0.77. Two people were known smokers (10.53%), while five were non-smokers (26.31%). Fifteen patients underwent an open operation (78.85%), with rest undergoing a minimally invasive approach. The majority of procedures were undertaken from the right-hand side. The overall intensive care unit admission rate was 68.42% (n = 13) with an in-hospital complication rate of 5.26% (n = 1). This was a respiratory arrest secondary to mucous plugging. There were no in-hospital deaths, and median follow-up was 41 months (22-50). Overall survival at 3 years was 85%.CONCLUSIONS Open thoracotomy remains an important surgical strategy in the management of complex mediastinitis, but further validation is required through larger, prospective studies.
   Mediastinitis is a rare but life-threatening condition that may result from deep sternal wound infection (DSWI), oesophageal perforation or descending necrotizing mediastinitis (DNM) [1].
C1 [Berjaoui, Nabih; Curti, Fabiana; Chan, Puiyee Sophia; Patel, Akshay; Bille, Andrea] Guys & St ThomasNHS Fdn Trust, Dept Thorac Surg, London, England.
   [Santos, Felix] Kings Coll Med Sch, London, England.
   [Lampridis, Savvas] 424 Gen Mil Hosp, Dept Thorac Surg, Thessaloniki, Greece.
   [Patel, Akshay] Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, England.
C3 University of London; King's College London; University of Birmingham
RP Patel, A (通讯作者)，Guys & St ThomasNHS Fdn Trust, Dept Thorac Surg, London, England.; Patel, A (通讯作者)，Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham, England.
EM ajp.788@gmail.com
RI ; Lampridis, Savvas/H-3539-2019
OI Santos, Felix/0009-0006-1795-1525; Patel, Akshay/0000-0001-9170-8618;
   Lampridis, Savvas/0000-0003-2827-5826
CR Abu-Omar Y, 2017, EUR J CARDIO-THORAC, V51, P10, DOI 10.1093/ejcts/ezw326
   Anger J, 2015, REV BRAS CIR CARDIOV, V30, P114, DOI 10.5935/1678-9741.20140033
   Bhatia P, 2011, ANN THORAC SURG, V92, P209, DOI 10.1016/j.athoracsur.2011.03.131
   Biere SSAY, 2011, DIGEST SURG, V28, P29, DOI 10.1159/000322014
   Chen KC, 2008, J THORAC CARDIOV SUR, V136, P191, DOI 10.1016/j.jtcvs.2008.01.009
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   Perrault LP, 2018, ANN THORAC SURG, V105, P461, DOI 10.1016/j.athoracsur.2017.06.078
   Prado-Calleros HM, 2016, HEAD NECK-J SCI SPEC, V38, pE2275, DOI 10.1002/hed.24183
   Price TN, 2013, ANN THORAC SURG, V95, P1154, DOI 10.1016/j.athoracsur.2012.11.045
   Ridder GJ, 2010, ANN SURG, V251, P528, DOI 10.1097/SLA.0b013e3181c1b0d1
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NR 26
TC 1
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2753-670X
J9 INTERDISC CARDIOV TH
JI Interdiscip. Cardiovasc. Thorac. Surg.
PD JUL
PY 2025
VL 40
IS 7
AR ivaf154
DI 10.1093/icvts/ivaf154
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 4UC4Y
UT WOS:001526707400001
PM 40576454
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Marena, F
   Brambullo, T
   Montrasio, L
   Baldan, N
   Mancini, F
   Vindigni, V
   Bassetto, F
AF Marena, Francesco
   Brambullo, Tito
   Montrasio, Lorenzo
   Baldan, Nicola
   Mancini, Francesca
   Vindigni, Vincenzo
   Bassetto, Franco
TI The role of negative incisional pressure in the prevention of surgical
   site complications in patients with median incisional hernia
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Incisional hernia; Single-use negative pressure; Surgical site
   occurrences; Abdominal wall reconstruction
ID WOUND THERAPY; MESH REPAIR; OUTCOMES; IMPACT
AB BackgroundA single-center retrospective study was conducted to investigate whether the prophylactic application of a single-use negative pressure wound therapy (sNPWT) dressing on closed surgical incisions following incisional hernia (IH) repair of the abdominal wall with meshes reduces the risk of surgical site occurrence (SSO) and the necessity for surgical reoperation. MethodsA retrospective study was conducted on 55 patients with incisional hernias classified as W2 (> 4-10 cm) or W3 (> 10 cm) according to the European Hernia Society classification, treated between 2013 and 2023. All patients underwent open surgical repair with mesh and were assigned to either a conventional flat dressing group (n = 34) or an sNPWT group using PICO 7 (n = 21). Weekly follow-ups were performed, and outcomes were statistically analyzed to compare the incidence of SSOs and reoperations between the two groups. ResultsAt 30 days postoperatively, the control group showed a higher incidence of SSOs (32.35%, 11 cases) compared to the PICO 7 group (19.05%, 4 cases, P = 0.28). The need for surgical reintervention was also higher in the control group (17.65%, 6 cases) versus the PICO 7 group (10.53%, 2 cases, P = 0.41). Regardless of dressing type, elevated BMI (P = 0.02), advanced age, and diabetes were identified as key risk factors for SSOs. ConclusionssNPWT with PICO 7 may reduce SSOs and reoperations in open incisional hernia repair, particularly in high-risk patients with elevated BMI. Although statistical significance was not achieved, sNPWT appears to be a valuable adjunct in postoperative management. Further research is necessary to confirm its efficacy and determine the ideal patient population.
C1 [Marena, Francesco; Brambullo, Tito; Montrasio, Lorenzo; Mancini, Francesca; Vindigni, Vincenzo; Bassetto, Franco] Univ Padua, Dept Neurosci, Clin Plast Surg, Via Giustiniani 2, Padua, Veneto, Italy.
   [Baldan, Nicola] Univ Padua, Dept Surg Oncol & Gastroenterol, Surg Clin 1, Padua, Italy.
C3 University of Padua; University of Padua
RP Brambullo, T (通讯作者)，Univ Padua, Dept Neurosci, Clin Plast Surg, Via Giustiniani 2, Padua, Veneto, Italy.
EM tito.brambullo@unipd.it
RI Brambullo, Tito/AAZ-2332-2020; Vindigni, Vincenzo/K-5059-2016
OI Brambullo, Tito/0000-0002-1041-9660; Vindigni,
   Vincenzo/0000-0001-6638-9010; Marena, Francesco/0009-0003-2455-9589
FU Universita degli Studi di Padova
FX Open access funding provided by Universita degli Studi di Padova.
CR Ahonen-Siirtola M, 2015, SCAND J SURG, V104, P66, DOI 10.1177/1457496914534208
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD JUN 7
PY 2025
VL 30
IS 1
AR 464
DI 10.1186/s40001-025-02724-y
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 4LK3F
UT WOS:001520799700001
PM 40481597
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chew, DS
   Dayal, T
AF Chew, Derek S.
   Dayal, Taranvir
TI Economic Analysis of AbClo, a Novel Abdominal Fascia Closure Device, for
   Patients With an Open Abdomen Following Trauma or Acute Abdominal
   Surgery
SO SURGICAL INNOVATION
LA English
DT Article
DE acute care surgery; general surgery; the business of surgery; health
   economics; cost-benefit
ID MANAGEMENT; LAPAROTOMY; MORTALITY
AB Background Open Abdomen (OA) cases represent a significant surgical and resource challenge. AbClo is a novel non-invasive abdominal fascial closure device that engages lateral components of the abdominal wall muscles to support gradual approximation of the fascia and reduce the fascial gap. The study objective was to assess the economic implications of AbClo compared to negative pressure wound therapy (NPWT) alone on OA management.Methods We conducted a cost-minimization analysis using a decision tree comparing the use of the AbClo device to NPWT alone among patients with midline laparotomy for trauma or acute abdominal surgery who were ineligible for primary fascial closure. The time horizon was limited to the length of the inpatient hospital stay, and costs were considered from the perspective of the US Medicare payer. Clinical effectiveness data for AbClo was obtained from a randomized clinical trial. Cost data was obtained from the published literature. Probabilistic and deterministic sensitivity analyses were performed. The primary outcome was incremental cost.Results The mean cumulative costs per patient were $76 582 for those treated with NPWT alone and $70,582 for those in the group treated with the AbClo device. Compared to NPWT alone, AbClo was associated with lower incremental costs of -$6012 (95% CI -$19 449 to +$1996). The probability that AbClo was cost-savings compared to NPWT alone was 94%.Conclusions The use of AbClo is an economically attractive strategy for management of OA in in patients with midline laparotomy for trauma or acute abdominal surgery who were ineligible for primary fascial closure.
C1 [Chew, Derek S.] Univ Calgary, O Brien Inst Publ Hlth, Dept Med, Calgary, AB, Canada.
   [Chew, Derek S.] Univ Calgary, Libin Cardiovasc Inst, Dept Cardiac Sci, Calgary, AB, Canada.
   [Dayal, Taranvir] InventoRR MD Inc, Toronto, ON, Canada.
   [Chew, Derek S.] Cardiac Sci & Med GE55, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
C3 University of Calgary; University of Calgary; Libin Cardiovascular
   Institute Of Alberta
RP Chew, DS (通讯作者)，Cardiac Sci & Med GE55, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
EM dchew@ucalgary.ca
FU InventoRR MD Inc.
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Financial
   support of this study was provided by InventoRR MD Inc.
CR [Anonymous], Acute Inpatient Prospective Payment System
   Betancourt AS, 2020, ANN MED SURG, V56, P11, DOI 10.1016/j.amsu.2020.06.007
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   U.S. Department of Labor: Bureau of Labor Statistics, 2020, CONSUMER PRICE INDEX
NR 18
TC 1
Z9 1
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD JUN
PY 2024
VL 31
IS 3
BP 233
EP 239
DI 10.1177/15533506241236745
EA FEB 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OP4Q6
UT WOS:001173369600001
PM 38411561
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Horriat, NL
   McCandless, MG
   Humphries, LS
   Ghanamah, M
   Kogon, BE
   Hoppe, IC
AF Horriat, Narges L.
   McCandless, Martin G.
   Humphries, Laura S.
   Ghanamah, Mohammed
   Kogon, Brian E.
   Hoppe, Ian C.
TI Management of pediatric sternal wounds following congenital heart
   surgery: The role of the plastic surgeon in debridement and closure
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE chest wall reconstruction; congenital heart disease; mediastinitis;
   muscle flap; sternal wound infection
ID MAJOR MUSCLE FLAP; MEDIASTINITIS; INFECTION
AB Background Management of sternal wound infections (SWIs) in pediatric patients following congenital heart surgery can be extremely difficult. Patients with congenital cardiac conditions are at risk for complications such as sternal dehiscence, infection, and cardiopulmonary compromise. In this study, we report a single-institution experience with pediatric SWIs. Methods Fourteen pediatric patients requiring plastic surgery consultation for complex sternal wound closure were included. A retrospective chart review was performed with the following variables of interest: demographic data, congenital cardiac condition, respective surgical palliations, development of mediastinitis, causative organism, number of debridements, presence of sternal wires, and choice of flap coverage. Primary endpoints included achieved chest wall closure and overall survival. Results Of the 14 patients, 8 (57%) were diagnosed with culture-positive mediastinitis. The sternum remained wired at the time of final flap closure in eight (57%) patients. All patients were reconstructed with pectoralis major flaps, except one (7%) who also received an omental flap and two (14%) who received superior rectus abdominis flaps. One patient (7%) was treated definitively with negative pressure wound therapy, and one (7%) was too unstable for closure. Six patients developed complications, including one (7%) with persistent mediastinitis, two (14%) with hematoma formation, one (7%) with abscess, and one (7%) with skin necrosis requiring subsequent surgical debridement. There were three (21%) mortalities. Conclusions The management of SWI in congenital cardiac patients is challenging. The standard tenets for management of SWI in adults are loosely applicable, but additional considerations must be addressed in this unique subset population.
C1 [Horriat, Narges L.; McCandless, Martin G.; Humphries, Laura S.; Hoppe, Ian C.] Univ Mississippi, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Jackson, MS 39216 USA.
   [Ghanamah, Mohammed; Kogon, Brian E.] Univ Mississippi, Med Ctr, Dept Surg, Div Cardiothorac Surg, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi
RP Hoppe, IC (通讯作者)，Univ Mississippi, Med Ctr, Div Plast & Reconstruct Surg, 2500N,State St, Jackson, MS 39216 USA.
EM ihoppe@umc.edu
OI McCandless, Martin/0000-0002-9068-8683
CR Al-Sehly AA, 2005, ANN THORAC SURG, V80, P2314, DOI 10.1016/j.athoracsur.2005.05.035
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   Falagas ME, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064741
   Grossfeld P, 2019, J CARDIOVASC DEV DIS, V6, DOI 10.3390/jcdd6010010
   Gursel E, 2002, PLAST RECONSTR SURG, V110, P844, DOI 10.1097/01.PRS.0000019917.27798.BE
   Horacio GD, 2017, BRAZ J CARDIOVA SURG, V32, P378, DOI 10.21470/1678-9741-2017-0038
   Jha P, 2020, PEDIATR CARDIOL, V41, P1402, DOI 10.1007/s00246-020-02396-x
   Ohye RG, 2004, J THORAC CARDIOV SUR, V128, P480, DOI 10.1016/j.jtcvs.2004.04.023
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   Salazard B, 2008, J PLAST RECONSTR AES, V61, P302, DOI 10.1016/j.bjps.2007.05.004
   Shin HJ, 2011, ANN THORAC SURG, V92, P705, DOI 10.1016/j.athoracsur.2011.03.040
   Song DH, 2003, PLAST RECONSTR SURG, V111, P92, DOI 10.1097/01.PRS.0000037686.14278.6A
   Sung K, 2004, ANN THORAC SURG, V77, P1371, DOI 10.1016/j.athoracsur.2003.06.020
   Taub PJ, 2005, ANN PLAS SURG, V55, P535, DOI 10.1097/01.sap.0000183681.56595.0a
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   Yabrodi M, 2017, PEDIATR RES, V81, P142, DOI 10.1038/pr.2016.194
NR 17
TC 3
Z9 3
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2022
VL 37
IS 11
BP 3695
EP 3702
DI 10.1111/jocs.16841
EA AUG 2022
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 5D1OI
UT WOS:000842165900001
PM 35979680
DA 2026-07-24
ER

PT J
AU Jacob-Brassard, J
   Al-Omran, M
   Salata, K
   Hussain, MA
   Kayssi, A
   Roche-Nagle, G
   de Mestral, C
AF Jacob-Brassard, Jean
   Al-Omran, Mohammed
   Salata, Konrad
   Hussain, Mohamad A.
   Kayssi, Ahmed
   Roche-Nagle, Graham
   de Mestral, Charles
TI A survey of Canadian surgeons on the indications for home care nursing
   following vascular surgery
SO CANADIAN JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 19th Annual Congress of the SSVq
CY NOV 21, 2019
CL Quebec, CANADA
SP SSVq
ID HEALTH-CARE; REPAIR; EUROPE
AB Background Recent evidence suggests that home care nursing is variably prescribed after vascular surgery, and may reduce emergency department visits and hospital readmissions. We therefore sought to characterize the indications for home care nursing following vascular surgery from the surgeon's perspective. Methods An online survey was distributed to the 141 members of the Canadian Society for Vascular Surgery with questions related to home care nursing after carotid endarterectomy (CEA), endovascular aortic aneurysm repair (EVAR), open abdominal aortic aneurysm (AAA) repair and open or hybrid revascularization for peripheral arterial disease (PAD). We included all questionnaires in our analysis; the frequency denominator changes according to the number of respondents who completed each survey item. Results There were 46 survey respondents (33% of 141) from across the country. A total of 28 (62% of 45) worked in a teaching hospital. Home care nursing was routinely prescribed by 5%, 10%, 31% and 41% of respondents following CEA, EVAR, open AAA repair and open or hybrid revascularization for PAD, respectively. Across all procedure types, the same procedure-related criteria were most often deemed to warrant a prescription for home care nursing: surgical site infection, wound complications (e.g., open wound, lymphatic leak) and use of negative-pressure wound therapy. Across all procedure types, lack of social support, physical frailty and cognitive impairment were most frequently identified as patient-specific considerations for prescribing home care nursing. Few respondents reported restrictions or standards that informed their prescribing practice. Conclusion Most surgeon respondents agreed on the indications for home care nursing after vascular surgery. However, evidence-based standards to guide patient selection for home care nursing after vascular surgery are needed.
C1 [Jacob-Brassard, Jean; Al-Omran, Mohammed; Salata, Konrad; Hussain, Mohamad A.; Kayssi, Ahmed; Roche-Nagle, Graham] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [Al-Omran, Mohammed; Salata, Konrad; Hussain, Mohamad A.; de Mestral, Charles] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Kayssi, Ahmed] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada.
   [Roche-Nagle, Graham] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Saint Michaels Hospital
   Toronto; Li Ka Shing Knowledge Institute; University of Toronto;
   Sunnybrook Health Science Center; Sunnybrook Research Institute;
   University of Toronto; University Health Network Toronto; Peter Munk
   Cardiac Centre
RP de Mestral, C (通讯作者)，St Michaels Hosp, 30 Bond St,Off Bond 7-080, Toronto, ON M5B 1W8, Canada.
EM charles.deMestral@unityhealth.to
RI Hussain, Mohamad/M-7595-2019; Al-Omran, Mohammed/IXX-0542-2023
OI Hussain, Mohamad/0000-0003-2471-8167; 
FU Blair Foundation Vascular Surgery Innovation Fund
FX This work was supported by the Blair Foundation Vascular Surgery
   Innovation Fund, jointly established with the University of Toronto.
CR [Anonymous], 2018, ARR CAR YOU LEAV HOS
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   Iida O, 2017, CIRC-CARDIOVASC INTE, V10, DOI 10.1161/CIRCINTERVENTIONS.117.005531
   Kaye DR, 2018, UROLOGY, V112, P74, DOI 10.1016/j.urology.2017.11.004
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   MOORE WS, 1995, STROKE, V26, P188, DOI 10.1161/01.STR.26.1.188
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   Tarricone R., 2008, Home care in Europe
   Zwolak RM, 2008, J VASC SURG, V48, P511, DOI 10.1016/j.jvs.2008.04.056
NR 24
TC 3
Z9 3
U1 0
U2 2
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 5W8, CANADA
SN 0008-428X
EI 1488-2310
J9 CAN J SURG
JI Can. J. Surg.
PD APR
PY 2021
VL 64
IS 2
BP E149
EP E154
DI 10.1503/cjs.001220
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA TA5UM
UT WOS:000667314200006
PM 33666391
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Monteiro, LH
   Da Silva, SKSM
   Benarrós, MSC
   Lopes, CTD
   Domingues, SFS
AF Monteiro, Louysse Helene
   Souza Marques Da Silva, Sandy Kelly
   Camara Benarros, Marina Sette
   De Albuquerque Lopes, Cinthia Tavora
   Souza Domingues, Sheyla Farhayldes
TI Use of Cost-effective Vacuum-assisted Closure Technique for Shell
   Fracture Repair and Coelomic Cavity Rupture Healing in a Chelonia
   carbonaria
SO ACTA SCIENTIAE VETERINARIAE
LA Portuguese
DT Article
DE Chelonoidis carbonaria; run over; vacuum-assisted therapy; shell repair;
   dental resin
AB Background: The vacuum-assisted closure (VAC) therapy system has been used as a noninvasive wound management technique for shell damage in Chelonians. These animals are excellent candidates for VAC therapy because of their unique shell anatomy consists of dermal bones, which make bandage placement easier. Beyond that, they are suited for this technique behaviorally, because they are not inclined to remove the vacuum system intentionally. Considering the possibility of Testudines shell repair with the use of less invasive techniques, that result no additional dermal bone lesions, the objective of the present study is to describe the adaptation of a vacuum dressing protocol using low-cost and easily accessible materials for post-traumatic shell healing of a specimen of Chelonoidis carbonaria.
   Case: A specimen of tortoise (Chelonoidis carbonaria), a male, weighing 630 g, approximately 3-year-old, was received at the Veterinary Hospital - Wild Animals Sector in the Federal University of Para (UFPA) after of being run over by a vehicle. On physical examination, fractures of the dermal plaques and underlying bone structures were found, with rupture of the coelomic cavity. In addition, there was exposure and incarceration of an intestinal loop, with the presence of bleeding. According to the findings of the physical screening examination, the patient's prognosis was defined as good, as described in the literature that specifically focused on chelonian shell injuries. The animal was sent to the diagnostic imaging sector. Then, drug therapy was provided for pain control, vitamins were administered for nutritional support, and antibiotics and anti-inflammatory drugs were instituted. For the closure of the shell and coelomic cavity, a bandage was used with the VAC therapy system adapted as described for Chelonians in previous reports. After a complete osteosynthesis and closure of the coelomic cavity, repair of the integumentary component of the shell was possible. For this procedure, the animal did not need to be anesthetized. The patient was physically restrained by being placed in suspension on a support with a diameter smaller than the plastron. Complete asepsis of the shell was necessary. On top of the lesion, a polypropylene mesh and color less dental resin were applied. The animal continued to be evaluated after the repair to check for potential complications. This procedure ensured that the repaired plates remained stable. Furthermore, the animal did not seem to have any discomfort with the resin when moving, so the animal was discharged after 25 days of hospitalization.
   Discussion: Radiography was important to determine the condition of the animal and clinical prognosis, and thus, to perform the proper treatment. The VAC therapy system was successful in assisting the patient's recovery. It enabled the reduction of the healing time since shell injuries usually require four to eighteen months to heal. In this report, the healing process only required 17 days, demonstrating that the VAC therapy system is a beneficial treatment to treat traumatic injuries in Testudines. The restoration protocol of the integumentary component using dental resin is less invasive, and this type of material has been used previously by other authors. Drug treatment with aminoglycosides and sulphonamides administered prophylactically has proven to be effective and has been used successfully in reptiles. These drugs may be combined with maintenance fluid therapy to prevent adverse reactions from aminoglycosides, such as nephrotoxicity. It was concluded that the use of the VAC therapy system reduced the time of post-traumatic healing of the carapace and proved to be an innovative approach to treat traumatic injuries in Testudines in a less invasive way.
C1 [Monteiro, Louysse Helene; Souza Marques Da Silva, Sandy Kelly] Univ Fed Para UFPA, Posgrad Saude Anim Amazonia PPGSAAM, Inst Med Vet IMV, Castanhal, PA, Brazil.
   [De Albuquerque Lopes, Cinthia Tavora; Souza Domingues, Sheyla Farhayldes] Univ Fed Para UFPA, Hosp Vet Setor Anim Silvestres HVSAS, Castanhal, PA, Brazil.
   [Camara Benarros, Marina Sette] Univ Fed Tocantins UFT, Programa Posgrad Sanidade Anim & Saude Publ Trop, Araguaina, TO, Brazil.
C3 Universidade Federal do Para; Universidade Federal do Para; Universidade
   Federal do Tocantins (UFT)
RP Monteiro, LH (通讯作者)，UFPA, PPGSAAM, Campus Castanhal,Br 316,Km 61, Castanhal, PA, Brazil.
EM helenelouysse@gmail.com
RI Souza Marques da Silva, Sandy Kelly/OTI-4324-2025; Souza Domingues,
   Sheyla Farhayldes/C-4406-2013
OI Souza Marques da Silva, Sandy Kelly/0000-0002-1326-1125; Souza
   Domingues, Sheyla Farhayldes/0000-0002-6017-7647; Monteiro, Louysse
   Helene/0000-0002-7845-3662; Benarrós, Marina/0000-0003-0680-5478
CR Adkesson MJ, 2007, JAVMA-J AM VET MED A, V231, P1249, DOI 10.2460/javma.231.8.1249
   Carpenter J.W., 2013, EXOTIC ANIMAL FORMUL, V5th, P127
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   Douglas Mader R., 2006, REPTILE MED SURG, V2nd, P428
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   Lafortune Maud, 2005, Journal of Herpetological Medicine and Surgery, V15, P4
   Machin Karen L., 2001, Veterinary Clinics of North America Exotic Animal Practice, V4, P19
   Maud L.M., 2014, CURRENT THERAPY REPT, P197
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   Souza A.M., 2009, REV BRAS ZOOL, V17, P1041
NR 15
TC 0
Z9 0
U1 1
U2 5
PU UNIV FED RIO GRANDE DO SUL
PI PORTO ALEGRE RS
PA FAC VET, CAIXA POSTAL 15017, PORTO ALEGRE RS, 91501-570, BRAZIL
SN 1678-0345
EI 1679-9216
J9 ACTA SCI VET
JI Acta Sci. Vet.
PY 2021
VL 49
SU 1
AR 623
DI 10.22456/1679-9216.104476
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA TU0PV
UT WOS:000680744800034
OA gold
DA 2026-07-24
ER

PT J
AU Molska, M
   Wojciech, M
   Murawa, D
AF Molska, Maja
   Wojciech, Magdalena
   Murawa, Dawid
TI Comparison of Single-Use Negative-Pressure Wound Therapy (sNPWT) and
   Standard Dressings Applied to the Same Patient During Bilateral Tissue
   Expander-to-Implant Exchanges
SO CANCERS
LA English
DT Article
DE breast cancer; breast reconstruction; wound healing; sNPWT; scar
ID BREAST RECONSTRUCTION; MASTECTOMY RATES; INCISION; SURGERY
AB Background: Breast cancer is the most common cancer among women. The number of cases is increasing among young women, and consequently, breast reconstructions are performed more often. Postoperative complications, wound healing, and the quality of scars influence the final cosmetic outcomes. The aim of the study was to investigate the effect of using a negative-pressure therapy compared to a standard dressing on two postoperative wounds in the same woman, after bilateral tissue expander replacement surgery-when identical healing conditions occur. Methods: This study includes a single-center evaluation of the application of two different dressings during bilateral exchanges of tissue expanders with breast implants. The study included 22 patients with a history of breast cancer after bilateral mastectomy with two-stage reconstruction. During the second stage, a sNPWT was applied to one breast and a standard dressing to the other. Results: A statistically significant difference in skin elasticity in favor of sNPWT was visible after 7 days, while the greatest difference was visible in the evaluation after 6 months (mean of 0.806 vs. 0.607). A difference in temperature measurements was shown 7 days after the procedure. However, after 30 days, these measurements were similar. There was also a reduced incidence of postoperative complications as well as seroma accumulation in the breasts with negative pressure. Conclusions: The results indicate faster healing, better scar quality, and improved skin elasticity in breasts with sNPWT compared to the standard dressing. The number of postoperative complications were also reduced, which is especially important in high-risk patients.
C1 [Molska, Maja; Murawa, Dawid] Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.
   [Molska, Maja; Murawa, Dawid] Univ Zielona Gora, Coll Med, Dept Surg & Oncol, PL-65046 Zielona Gora, Poland.
   [Wojciech, Magdalena] Univ Zielona Gora, Inst Math, PL-65417 Zielona Gora, Poland.
C3 University of Zielona Gora; University of Zielona Gora
RP Molska, M (通讯作者)，Univ Hosp Zielona Gora, Clin Dept Gen & Oncol Surg, PL-65046 Zielona Gora, Poland.; Molska, M (通讯作者)，Univ Zielona Gora, Coll Med, Dept Surg & Oncol, PL-65046 Zielona Gora, Poland.
EM majaa.molska@gmail.com
RI ; Wojciech, Magda/ABB-5969-2021
OI , Maja Molska/0009-0005-4802-7979; Murawa, Dawid/0000-0003-3156-1882; 
CR Angarita AM, 2022, AM J OBST GYNEC MFM, V4, DOI 10.1016/j.ajogmf.2022.100617
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   Carrière ME, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002424
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   Wareham CM, 2023, PRS-GLOB OPEN, V11, DOI 10.1097/GOX.0000000000004936
NR 32
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JAN
PY 2025
VL 17
IS 1
AR 3
DI 10.3390/cancers17010003
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA R7S9M
UT WOS:001393412200001
PM 39796634
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Prabakaran, PP
   Totty, JP
   Carradice, D
   Chetter, IC
   Smith, GE
AF Prabakaran, Praveena Priyadharsini
   Totty, Joshua P.
   Carradice, Dan
   Chetter, Ian C.
   Smith, George E.
TI The local physiological effects of a single-use topical negative
   pressure device in healthy volunteers: the PICO-1 study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE angiogenesis; healing; negative pressure; negative pressue wound
   therapy; PICO; perfusion; tissue oxygenation; tNPWT; wound; wound care;
   wound dressing; wound healing
ID CLOSED INCISION MANAGEMENT; WOUND THERAPY; BLOOD-FLOW
AB Objective: This study aimed to investigate the effects of a single-use negative pressure wound therapy (sNPWT) device on tissue perfusion, oxygenation and pressure in the intact skin of healthy volunteers.
   Method: Healthy volunteers wore a PICO sNPWT device (Smith+Nephew, UK) on their right medial calf for one week. Perfusion, tissue oxygenation and tissue pressure were recorded in superficial and deep tissues over a period of seven days. At the baseline visit, measurements were recorded before and after dressing application without activation. Macrovascular flow and transduced needle pressure measures were recorded at 0 minutes, 30 minutes and 60 minutes after device activation. Superficial tissue perfusion and both oxygenation measures were recorded continuously over the hour following activation. All outcome measures were repeated at 24 hours and again after seven days, both with the dressing and following dressing removal.
   Results: The device was associated with a measurable increase in perfusion of the limb in 12 healthy volunteers. Superficial tissue oxygenation adjacent to the dressing was reduced during wear, while deeper tissue demonstrated an increase in oxygenation levels. Superficial skin perfusion was observed to differ between skin overlying muscle and that overlying bone. Pressure in tissue underneath the dressing pad was increased throughout dressing wear and returned to baseline levels on dressing removal.
   Conclusion: sNPWT produced measurable changes in local physiology in healthy volunteers with intact skin, despite the absence of a wound. Effects may differ according to anatomical site and the composition of underlying tissues. Other factors that promote healing were not explored in this study.
C1 [Prabakaran, Praveena Priyadharsini; Totty, Joshua P.; Carradice, Dan; Chetter, Ian C.; Smith, George E.] Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.
   [Totty, Joshua P.] Hull Univ Teaching Hosp, Dept Plast & Reconstruct Surg, Cottingham, England.
C3 University of Hull
RP Totty, JP (通讯作者)，Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, N Humberside, England.; Totty, JP (通讯作者)，Hull Univ Teaching Hosp, Dept Plast & Reconstruct Surg, Cottingham, England.
EM joshua.totty@hyms.ac.uk
RI ; Carradice, Daniel/AFN-0257-2022; Totty, Joshua P/AAP-6655-2020
OI Smith, George/0000-0002-8085-0886; chetter, ian/0000-0002-2566-6859;
   Carradice, Daniel/0000-0002-7733-3925; Totty, Joshua
   P/0000-0002-0063-1414
FU Smith+Nephew [IIS 684]
FX This study was funded by Smith+Nephew investigator-initiated grant IIS
   684. The funder had no input into study design, conduct, analysis,
   manuscript preparation or dissemination. The authors have no conflicts
   of interest to declare.
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2022
VL 31
IS 8
BP 624
EP 632
DI 10.12968/jowc.2022.31.8.624
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4D0UE
UT WOS:000846858500002
PM 36001706
DA 2026-07-24
ER

PT J
AU Pesch, S
   Hanschen, M
   Greve, F
   Zyskowski, M
   Seidl, F
   Kirchhoff, C
   Biberthaler, P
   Huber-Wagner, S
AF Pesch, Sebastian
   Hanschen, Marc
   Greve, Frederik
   Zyskowski, Michael
   Seidl, Fritz
   Kirchhoff, Chlodwig
   Biberthaler, Peter
   Huber-Wagner, Stefan
TI Treatment of fracture-related infection of the lower extremity with
   antibiotic-eluting ceramic bone substitutes: case series of 35 patients
   and literature review
SO INFECTION
LA English
DT Review
DE Fracture-related infection; Ceramic bone substitute; Antibiotic-eluting
   ceramic bone substitute; Bone infection; Cerament (TM) G
ID CHRONIC OSTEOMYELITIS; DEFECTS
AB Introduction The current treatment concepts of fracture-related infection (FRI) [Consensus Conference (Anti-Infection Task Force (AITF)) on the definition of acute or chronic osteomyelitis (cOM)] are associated with unsolved challenges and problems, underlining the need for ongoing medical research. Method Literature review of treatments for FRI and description of own cases. Results We could include eight papers with 394 patients reporting treatments and outcome in FRI. The infection was resolved in 92.9% (mean) of all treatments. The mean follow-up was 25 months with a persistent non-union in 7% of the patients. We diagnosed 35 (19f/16m; 56.4 +/- 18.6 years) patients with bone infections anatomically allocated to the proximal and distal femur (12x), the pelvis (2x), distal tibia (3x), tibial diaphysis (11x), the ankle joint (4x) and calcaneus (3x). These 35 patients were treated (1) with surgical debridement; (2) with antibiotic-eluting ceramic bone substitutes; (3) bone stabilization (including nail fixation, arthrodesis nails, plates, or external ring fixation), (4) optionally negative pressure wound therapy (NPWT) and (5) optionally soft tissue closure with local or free flaps. The mean follow-up time was 14.9 +/- 10.6 months (min/max: 2/40 month). The overall recurrence rate is low (8.5%, 3/35). Prolonged wound secretion was observed in six cases (17.1%, 6/35). The overall number of surgeries was a median of 2.5. Conclusion The results in the literature and in our case series are explicitly promising regarding the treatment of posttraumatic fracture-related infection.
C1 [Pesch, Sebastian; Hanschen, Marc; Greve, Frederik; Zyskowski, Michael; Seidl, Fritz; Kirchhoff, Chlodwig; Biberthaler, Peter; Huber-Wagner, Stefan] Tech Univ Munich, Sch Med, Dept Trauma Surg, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany.
C3 Technical University of Munich
RP Pesch, S (通讯作者)，Tech Univ Munich, Sch Med, Dept Trauma Surg, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany.
EM sebastian.pesch@mri.tum.de
RI Hanschen, Marc/KIL-5562-2024
OI Hanschen, Marc/0000-0002-2683-9870
FU Projekt DEAL
FX Open Access funding provided by Projekt DEAL.
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NR 26
TC 36
Z9 41
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
EI 1439-0973
J9 INFECTION
JI Infection
PD JUN
PY 2020
VL 48
IS 3
BP 333
EP 344
DI 10.1007/s15010-020-01418-3
EA APR 2020
PG 12
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA LS4PS
UT WOS:000524894200001
PM 32270441
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ordoñez, CA
   Parra, MW
   Millán, M
   Caicedo, Y
   Padilla, N
   Guzmán-Rodríguez, M
   Miñan-Arana, F
   García, A
   González-Hadad, A
   Pino, LF
   Rodríguez-Holguin, F
   Serna, JJ
   Salcedo, A
   Ferrada, R
   Ivatury, R
AF Ordonez, Carlos A.
   Parra, Michael W.
   Millan, Mauricio
   Caicedo, Yaset
   Padilla, Natalia
   Guzman-Rodriguez, Monica
   Minan-Arana, Fernando
   Garcia, Alberto
   Gonzalez-Hadad, Adolfo
   Fernando Pino, Luis
   Rodriguez-Holguin, Fernando
   Julian Serna, Jose
   Salcedo, Alexander
   Ferrada, Ricardo
   Ivatury, Rao
TI Pancreatic damage control: the pancreas is simple don't complicate it
SO COLOMBIA MEDICA
LA English
DT Article
DE Pancreatic Damage Control; Suture; Drainage; Pancreatic Fistula;
   Pancreatectomy; Peritoneal Cavity; Amylases; Ampulla of Vater; Enteral
   Nutrition; Splenectomy; Negative-Pressure Wound Therapy; Critical
   Illness; Cholecystostomy; Operating Rooms; Laparotomy; Lacerations
ID MANAGEMENT; TRAUMA; TOMOGRAPHY
AB Pancreatic trauma is a rare but potentially lethal injury because often it is associated with other abdominal organ or vascular injuries. Usually, it has a late clinical presentation which in turn complicates the management and overall prognosis. Due to the overall low prevalence of pancreatic injuries, there has been a significant lack of consensus among trauma surgeons worldwide on how to appropriately and efficiently diagnose and manage them. The accurate diagnosis of these injuries is difficult due to its anatomical location and the fact that signs of pancreatic damage are usually of delayed presentation. The current surgical trend has been moving towards organ preservation in order to avoid complications secondary to exocrine and endocrine function loss and/or potential implicit post-operative complications including leaks and fistulas. The aim of this paper is to propose a management algorithm of patients with pancreatic injuries via an expert consensus. Most pancreatic injuries can be managed with a combination of hemostatic maneuvers, pancreatic packing, parenchymal wound suturing and closed surgical drainage. Distal pancreatectomies with the inevitable loss of significant amounts of healthy pancreatic tissue must be avoided. General principles of damage control surgery must be applied when necessary followed by definitive surgical management when and only when appropriate physiological stabilization has been achieved. It is our experience that viable un-injured pancreatic tissue should be left alone when possible in all types of pancreatic injuries accompanied by adequate closed surgical drainage with the aim of preserving primary organ function and decreasing short and long term morbidity.
C1 [Ordonez, Carlos A.; Garcia, Alberto; Rodriguez-Holguin, Fernando; Julian Serna, Jose; Salcedo, Alexander] Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Garcia, Alberto; Gonzalez-Hadad, Adolfo; Fernando Pino, Luis; Julian Serna, Jose; Salcedo, Alexander; Ferrada, Ricardo] Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Ordonez, Carlos A.; Millan, Mauricio; Rodriguez-Holguin, Fernando; Julian Serna, Jose; Salcedo, Alexander] Univ Icesi, Cali, Colombia.
   [Parra, Michael W.] Broward Gen Level I Trauma Ctr, Dept Trauma Crit Care, Ft Lauderdale, FL USA.
   [Millan, Mauricio] Fdn Valle Lili, Dept Surg, Div Transplant Surg, Cali, Colombia.
   [Caicedo, Yaset; Padilla, Natalia] Fdn Valle Lili, Ctr Invest Clin CIC, Cali, Colombia.
   [Guzman-Rodriguez, Monica] Univ Chile, Fac Med, Inst Ciencias Biomed, Santiago, Chile.
   [Minan-Arana, Fernando] Univ Espiritu Santo, Dept Surg, Guayaquil, Ecuador.
   [Minan-Arana, Fernando] Hosp Dr Abel Gilbert Ponton, Dept Surg, Div Trauma & Acute Care Surg, Guayaquil, Ecuador.
   [Garcia, Alberto; Gonzalez-Hadad, Adolfo; Fernando Pino, Luis; Julian Serna, Jose; Salcedo, Alexander] Hosp Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.
   [Gonzalez-Hadad, Adolfo; Ferrada, Ricardo] Ctr Med Imbanaco, Cali, Colombia.
   [Ivatury, Rao] Virginia Commonwealth Univ, Richmond, VA USA.
C3 Fundacion Valle del Lili; Universidad del Valle; Universidad ICESI;
   Fundacion Valle del Lili; Fundacion Valle del Lili; Universidad de
   Chile; Universidad de Especialidades Espiritu Santo; Universidad del
   Valle; Virginia Commonwealth University
RP Ordoñez, CA (通讯作者)，Fdn Valle Lili, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Univ Valle, Dept Surg, Div Trauma & Acute Care Surg, Cali, Colombia.; Ordoñez, CA (通讯作者)，Univ Icesi, Cali, Colombia.
EM ordonezcarlosa@gmail.com
OI Padilla-Londoño, Natalia/0000-0003-3292-6919; PINO OLIVEROS, LUIS
   FERNANDO/0000-0002-1179-2854
CR Ahmed N, 2009, SOUTH MED J, V102, P1253, DOI 10.1097/SMJ.0b013e3181c0dfca
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NR 25
TC 11
Z9 12
U1 0
U2 1
PU CORPORACION EDITORA MEDICA VALLE
PI CALI
PA UNIV VALLE, BLDG 118 FACULTY HEALTH, CALLE 4B 36-00, CALI, 00000,
   COLOMBIA
SN 1657-9534
J9 COLOMB MEDICA
JI Colomb. Medica
PY 2020
VL 51
IS 4
AR e-4054361
DI 10.25100/cm.v51i4.4361
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ8US
UT WOS:000613024700004
PM 33795904
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cottom, JM
   Verdoni, TJ
AF Cottom, James M.
   Verdoni, Tyler J.
TI Evaluation of incisional negative pressure wound therapy with anterior
   approach total ankle arthroplasty
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Ankle replacement; Incision healing; Wound vac
ID SURGICAL INCISION; COMPLICATIONS; CLASSIFICATION; MANAGEMENT; SURGERY;
   HIP
AB Background: Total ankle replacement continues to find significantly increased utilization as the technology advances. While there are different systems on the market, most are implanted through an anterior incisional approach just lateral to the tibialis anterior tendon. This incision is prone to decreased wound healing, increased time to healing, and postoperative dehiscence and infection risk. When patient comorbid medical conditions are taken into consideration as well, the chance of complications increases significantly. To date, multiple articles have been published discussing how to decrease complication rate associated with this higher risk incision, such as different suturing patterns, utilization of a postoperative drain, and incisional wound vac application (iNPWT). Purpose: The purpose of this study is to present our results with iNPWT utilization for anterior approach total ankle arthroplasty. Methods: Thirty one (31) patient's consecutive total ankle replacement (TARs) were retrospectively reviewed. Eleven [11] patients underwent TAR with iNPWT (Group 1) application and 20 patients underwent TAR without iNPWT (Group 2) application. Results: In group 1, wound complications were 1/11 (9 %) and in group 2 wound complications were 4/20(20 %); with an overall 5/31 (16%) wound complication rate (p value 0.429). Conclusion: In our present study, we identified a reduction of wound healing complications by 11 % when comparing the two groups, although failed to reach statistical significance. While future studies are needed with more patient enrollment, iNPWT application is a quick and safe method to help reduce complications associated with the anterior approach for total ankle replacement. (c) 2025 by the American College of Foot and Ankle Surgeons. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Cottom, James M.; Verdoni, Tyler J.] Florida Orthoped Foot & Ankle Ctr, Modern Foot & Ankle, 5741 Bee Ridge Rd,Suite 490, Sarasota, FL 34233 USA.
RP Cottom, JM (通讯作者)，Florida Orthoped Foot & Ankle Ctr, Modern Foot & Ankle, 5741 Bee Ridge Rd,Suite 490, Sarasota, FL 34233 USA.
EM Jamescottom300@hotmail.com
CR [Anonymous], 2000, J ARTHROPLASTY, V36, P2402
   Bibbo C, 2013, J FOOT ANKLE SURG, V52, P136, DOI 10.1053/j.jfas.2012.10.010
   Brem MH, 2014, INT WOUND J, V11, P3, DOI 10.1111/iwj.12252
   Elliott Andrew D, 2017, Open Orthop J, V11, P678, DOI [10.2174/1874325001711010678, 10.2174/1874325001711010678]
   Gadd RJ, 2014, FOOT ANKLE INT, V35, P434, DOI 10.1177/1071100714524549
   Glazebrook MA, 2009, FOOT ANKLE INT, V30, P945, DOI 10.3113/FAI.2009.0945
   Gougoulias N, 2010, CLIN ORTHOP RELAT R, V468, P199, DOI 10.1007/s11999-009-0987-3
   Groenen H, 2023, ECLINICALMEDICINE, V62, DOI 10.1016/j.eclinm.2023.102105
   Hansen E, 2013, CLIN ORTHOP RELAT R, V471, P3230, DOI 10.1007/s11999-013-2937-3
   Helito CP, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03510-z
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   Ramez Sakkab, 2024, FOOT ANKLE SURG
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   Rushing Calvin J, 2023, FOOT ANKLE SURG, V3
   Scalise A, 2015, INT WOUND J, P1260
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR-APR
PY 2026
VL 65
IS 2
BP 60e1
EP 60e5
DI 10.1053/j.jfas.2025.11.010
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA FE1GR
UT WOS:001716575400001
PM 41242546
DA 2026-07-24
ER

PT J
AU Nuhi, A
AF Nuhi, Arslani
TI Case Study: Infected Disrupted Perineal Wound Treatment with Negative
   Pressure Wound Therapy (NPWT) and Wound Reconstruction Using Gracilis
   Muscle Flap Following the Abdominoperineal Excision (APE) in Patient
   with Rectum Injury Due to Motorcycle Accident
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Rectum injury; APE; NPWT; Gracilis muscle flap; Interdisciplinary
   approach
ID MANAGEMENT
AB Blunt trauma sustained in traffic accidents can cause significant rectum injury, either intra or extraperitoneal. Severe injuries have high mortality rates and many complications, including pelvic absesses, sepsis, rectal fistulas, stenosis, and rectal incontinence. Following the initial surgical procedure, many reconstructive methods can be used to treat perineal wounds, including gracilis myocutaneus flap, rectus abdominis flap, gluteal flap, perforator flap, posterior thigh flap, groin flap, and pudendal fasciocutaneous flap. NPWT is used to promote formation of granulation tissue, reduce and prepare tissue gap to be covered, improve perfusion through removal of excessive fluid, and reduce bacterial wound colonization. Some of the complications of this method are pain, skin irritation and maceration, tissue necrosis, bleeding, and infection. The success rate of NPWT depends on multiple factors, including patient characteristics, effectiveness of primary surgical procedure and need for further surgical interventions, size and depth of the wound, and proper NPWT application technique. NPWT has shown to reduce total treatment cost due to shorter patient hospital stay, reduction of complication rates, reduction of further surgical interventions, and lower frequency of dressing change compared with standard dressings. In this case study, I present a 53-year-old motorcyclist who was injured in a traffic accident and sustained fracture of the sacrum, rupture of the pubic symphysis, fracture of L5 vertebrae, and penetrant injury to the rectum. Multiple explorative laparotomies, colostomy, and supportive and drug treatment methods were carried out to obtain a successful outcome.
C1 [Nuhi, Arslani] Univ Med Ctr Maribor, Dept Abdominal & Gen Surg, Maribor, Slovenia.
C3 University of Maribor
RP Nuhi, A (通讯作者)，Univ Med Ctr Maribor, Dept Abdominal & Gen Surg, Maribor, Slovenia.
EM nuhi.arslani@gmail.com
CR Cruceru AM, 2016, CASE REP SURG, V2016, DOI 10.1155/2016/4830712
   Gonzalez R P, 2002, Scand J Surg, V91, P87
   Guy Heidi, 2012, Nurs Times, V108, P20
   Johnson EK, 2013, J GASTROINTEST SURG, V17, P1712, DOI 10.1007/s11605-013-2271-9
   Merlino JI, 2004, Semin Colon Rectal Surg, V15, P95, DOI DOI 10.1053/J.SCRS.2004.10.004
   Searle R, 2010, WOUNDS UK, V6, P106
   Sharma RK, 2012, INDIAN J PLAST SURG, V45, P352, DOI 10.4103/0970-0358.101318
   Weinberg JA, 2006, J TRAUMA, V60, P508, DOI 10.1097/01.ta.0000205808.46504.e9
NR 8
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD APR
PY 2021
VL 83
IS SUPPL 1
SU 1
SI SI
BP S222
EP S224
DI 10.1007/s12262-020-02099-w
EA NOV 2020
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB9DV
UT WOS:000591229400002
DA 2026-07-24
ER

PT J
AU Cicuttin, E
   Ansaloni, L
   Ceresoli, M
   Fugazzola, P
   Tomasoni, M
   Sartelli, M
   Catena, F
   Coccolini, F
   Montori, G
   Salvetti, F
   Zese, M
   Occhionorelli, S
   Galatioto, C
   Chiarugi, M
   Dondossola, D
   Novelli, G
   Nacoti, M
   Costa, S
   Zoro, T
   Trotta, F
   Rausei, S
   Bellanova, G
   Costa, G
   Porta, M
   Mariani, F
   Lora, F
   Fattori, L
   Jacopo, V
   Lorenzo, C
AF Cicuttin, Enrico
   Ansaloni, Luca
   Ceresoli, Marco
   Fugazzola, Paola
   Tomasoni, Matteo
   Sartelli, Massimo
   Catena, Fausto
   Coccolini, Federico
   Montori, Giulia
   Salvetti, Francesco
   Zese, Monica
   Occhionorelli, Savino
   Galatioto, Christian
   Chiarugi, Massimo
   Dondossola, Daniele
   Novelli, Giuseppe
   Nacoti, Mirco
   Costa, Stefano
   Zoro, Tamara
   Trotta, Francesco
   Rausei, Stefano
   Bellanova, Giovanni
   Costa, Gianluca
   Porta, Matteo
   Mariani, Federico
   Lora, Federico
   Fattori, Luca
   Jacopo, Vigano
   Lorenzo, Cobianchi
CA Italian IROA Study Grp
TI Trends in open abdomen management in Italy: a subgroup analysis from the
   IROA project
SO UPDATES IN SURGERY
LA English
DT Article
DE Open abdomen; Management; Laparostomy; Complication; Mortality;
   Morbidity; Peritonitis; Pancreatitis; Trauma; Vascular emergency;
   Register; Fistula; IROA
ID ABDOMINAL COMPARTMENT SYNDROME; CLOSURE
AB Use of open abdomen (OA) progressively acquired increasing importance with the diffusion of the damage control management of critical patients. The purpose of the present study is to identify the state of the art about the use of OA in Italy, focusing on techniques, critical issues and clinical outcomes. A prospective analysis of adult patients enrolled in the IROA, limited to the Italian participating centres was performed. 375 patients were enrolled. Mean age was 64 +/- 16 years old, 56% of the patients were male, mean BMI was 26.9 +/- 5.2. Main indications for using OA were secondary peritonitis (32.5%), post-operative peritonitis (22.9%) and trauma (11.7%). Main OA techniques used were commercial negative pressure wound therapy (49.6%) and Bogota bag (27.7%). Definitive closure of the abdomen was reached in 82.4% of patients after 6 +/- 7 days of OA. The primary fascia closure rate was 84.7%. Overall mortality was 29.1%. The complication rate was 50.8%, with an enteroatmospheric fistula incidence: 7.5%. A univariate analysis performed on complication type found the duration of OA treatment (p = 0.024) to be statistically significant. Univariate analysis on mortality risk identified as significant age, duration of OA (in days) and pancreatitis as indication; multivariate analysis confirmed age (p < 0.001) and pancreatitis (p = 0.002) as statistically significant. A large variety of behaviours towards the patient requiring OA exists. A strong acceptance of common, recognized and evidence-based guidelines is essential, to obtain more uniformity in patient management and coherence of collected data, thus leading to improvement in outcomes and reduction of costs.
C1 [Cicuttin, Enrico; Ansaloni, Luca; Fugazzola, Paola; Tomasoni, Matteo; Coccolini, Federico; Salvetti, Francesco] Bufalini Hosp, Gen Emergency & Trauma Surg Dept, Viale Giovanni Ghirotti 286, I-47521 Cesena, Italy.
   [Cicuttin, Enrico; Zoro, Tamara; Lorenzo, Cobianchi] Univ Pavia, Dipartimento Sci Clin Chirurg Diagnost & Pediat, Pavia, Italy.
   [Ceresoli, Marco; Fattori, Luca] Milano Bicocca Univ, Gen & Emergency Surg, Sch Med & Surg, Monza, Italy.
   [Sartelli, Massimo] Macerata Hosp, Gen & Emergency Surg, Macerata, Italy.
   [Catena, Fausto] Parma Univ Hosp, Emergency Surg Dept, Parma, Italy.
   [Montori, Giulia] San Giovanni Bianco Hosp, Gen Surg, Bergamo, Italy.
   [Zese, Monica; Occhionorelli, Savino] Ferrara Univ Hosp, Emergency Surg Dept, Ferrara, Italy.
   [Galatioto, Christian; Chiarugi, Massimo] Azienda Osped Univ Pisana, Pisa, Italy.
   [Dondossola, Daniele] Fdn IRCCS Ca Granda Osped Maggiore Policlin, HPB Surg, Milan, Italy.
   [Novelli, Giuseppe] Infermi Hosp, Gen Surg, Rimini, Italy.
   [Nacoti, Mirco] Papa Giovanni XXIII Hosp, Pediat Intens Care Unit, Bergamo, Italy.
   [Costa, Stefano] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Emergency & Gen Surg, Milan, Italy.
   [Trotta, Francesco] Osped Maggiore Lodi, Lodi, Italy.
   [Rausei, Stefano] Univ Insubria, Osped Circolo & Fdn Macchi, Varese, Italy.
   [Bellanova, Giovanni] SS Annunziata Hosp, Taranto, Italy.
   [Costa, Gianluca] Osped St Andrea Univ Hosp Sapienza, Rome, Italy.
   [Porta, Matteo] IRCCS Policlin San Donato, Gen Surg, Milan, Italy.
   [Mariani, Federico] Santa Maria Scotte Univ Hosp, Gen Surg, Siena, Italy.
   [Lora, Federico] Citta Salute & Sci, Gen Surg, Turin, Italy.
   [Jacopo, Vigano] Fdn IRCCS Policlin San Matteo, Chirurg Gen 1, Pavia, Italy.
C3 University of Pavia; University of Milano-Bicocca; University of Parma;
   University Hospital of Parma; University of Ferrara; Arcispedale
   Sant'Anna; University of Pisa; Azienda Ospedaliero Universitaria Pisana;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; Hospital of Rimini; ASST
   Papa Giovanni XXIII; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   Ospedale Maggiore di Lodi; University of Insubria; Ospedale Circolo &
   Fondazione Macchi; IRCCS Policlinico San Donato; University of Siena;
   University Hospital of Siena; A.O.U. Citta della Salute e della Scienza
   di Torino; IRCCS Fondazione San Matteo
RP Coccolini, F (通讯作者)，Bufalini Hosp, Gen Emergency & Trauma Surg Dept, Viale Giovanni Ghirotti 286, I-47521 Cesena, Italy.
EM federico.coccolini@gmail.com
RI Ceresoli, Marco/GMW-5356-2022; Novelli, Giuseppe/A-5195-2013; Cobianchi,
   Lorenzo/AAC-2282-2022; Cicuttin, Enrico/GXG-6365-2022; Occhionorelli,
   Savino/AAB-2552-2022; Tomasoni, Matteo/AAC-3732-2022; Rausei,
   Stefano/AAM-7898-2021; /AAD-7440-2020; Costa, Gianluca/ABD-7262-2020;
   Ansaloni, Luca/AAP-9134-2020; dondossola, daniele/A-7978-2016; Ansaloni,
   Luca/AAJ-6507-2020; Fugazzola, Paola/AAH-4680-2019; Chiarugi,
   Massimo/ABQ-7280-2022; Porta, Matteo/AAQ-4219-2021; Nacoti,
   Mirco/AFV-9624-2022; Montori, Giulia/ABF-9661-2020
OI Cicuttin, Enrico/0000-0003-4584-9940; Zese, Monica/0000-0002-4768-6746;
   Costa, Gianluca/0000-0001-5194-8908; Salvetti,
   Francesco/0000-0001-8472-5823; Ansaloni, Luca/0000-0001-6427-0307;
   dondossola, daniele/0000-0002-4374-3184; Ansaloni,
   Luca/0000-0001-6427-0307; Fugazzola, Paola/0000-0002-6227-9276;
   Chiarugi, Massimo/0000-0001-6905-2499; Porta,
   Matteo/0000-0002-5787-4433; Nacoti, Mirco/0000-0002-8737-9812; Montori,
   Giulia/0000-0002-7649-2174
CR Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Burlew CC, 2011, J TRAUMA, V70, P273, DOI 10.1097/TA.0b013e3182050eb7
   Coccolini F, 2019, INJURY, V50, P160, DOI 10.1016/j.injury.2018.09.040
   Coccolini F, 2018, WORLD J EMERG SURG, V13, DOI 10.1186/s13017-018-0167-4
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0146-1
   Coccolini F, 2017, WORLD J EMERG SURG, V12, DOI 10.1186/s13017-017-0123-8
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Kirkpatrick AW, 2013, INTENS CARE MED, V39, P1190, DOI 10.1007/s00134-013-2906-z
   Miller RS, 2005, J TRAUMA, V59, P1365, DOI 10.1097/01.ta.0000196004.49422.af
   Mintziras I, 2016, LANGENBECK ARCH SURG, V401, P619, DOI 10.1007/s00423-016-1443-y
   Regner JL, 2012, WORLD J SURG, V36, P497, DOI 10.1007/s00268-011-1203-7
   Sartelli M, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0032-7
   van Brunschot S, 2014, PANCREAS, V43, P665, DOI 10.1097/MPA.0000000000000108
   van Hensbroek PB, 2009, WORLD J SURG, V33, P199, DOI 10.1007/s00268-008-9867-3
NR 14
TC 6
Z9 7
U1 0
U2 0
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 2038-131X
EI 2038-3312
J9 UPDATES SURG
JI Updates Surg.
PD MAR
PY 2020
VL 72
IS 1
BP 171
EP 177
DI 10.1007/s13304-019-00687-4
EA OCT 2019
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KU7IL
UT WOS:000490890200002
PM 31621034
DA 2026-07-24
ER

PT J
AU Mirzabeigi, MN
   Wilson, AJ
   Fischer, JP
   Basta, M
   Kanchwala, S
   Kovach, SJ
   Serletti, JM
   Wu, LC
AF Mirzabeigi, Michael N.
   Wilson, Anthony J.
   Fischer, John P.
   Basta, Marten
   Kanchwala, Suhail
   Kovach, Stephen J.
   Serletti, Joseph M.
   Wu, Liza C.
TI Predicting and Managing Donor-Site Wound Complications in Abdominally
   Based Free Flap Breast Reconstruction: Improved Outcomes with Early
   Reoperative Closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT Aesthetic Meeting
CY APR 24-29, 2014
CL San Francisco, CA
ID FREE TISSUE TRANSFER; SPARING FREE TRAM; DIEP FLAP; FUNCTIONAL IMPACT;
   MYOCUTANEOUS FLAP; MORBIDLY OBESE; SIEA FLAPS; WALL; ABDOMINOPLASTY;
   EXPERIENCE
AB Background: The purpose of this study was to (1) determine risk factors predictive of delayed abdominal healing; (2) determine characteristics that perpetuate progression to chronic abdominal wounds and describe the resultant morbidity; and (3) identify outcomes and cost following two treatment strategies-conservative wound care and early reoperative primary closure.
   Methods: Patients were identified from a database of abdominally based free flaps performed from January of 2005 through July of 2012.
   Results: One thousand two hundred eighteen abdominal donor sites were reviewed, and 167 cases (13.7 percent) of delayed abdominal wound healing were identified. Obesity (p < 0.0001), smoking (p = 0.043), bilateral reconstruction (p = 0.006), preoperative chemotherapy (p = 0.006), and abdominal mesh (p = 0.028) were independently associated with delayed healing. Initiation of chemotherapy p < 0.0001), wet-to-dry wound care (p = 0.001), negative-pressure wound therapy (p = 0.002), and flap type (p = 0.047) were predictive of chronic wounds, and such wounds generated higher rates of hospital readmission (p = 0.009), mesh complications (p < 0.001), and hernia/bulge (p = 0.006). Patients who underwent delayed primary wound closure were more likely to have a well-healed abdomen within 1 month (90.9 percent versus 24.2 percent; p < 0.0001), resulting in lower cost, fewer hospital readmissions, lower rates of scar revision, and lower rates of mesh complications/hernia/bulge.
   Conclusions: Chronic abdominal wounds were associated with abdominal wall sequelae, including hernia. Early reoperative primary wound closure has been successfully and selectively implemented, resulting in improved patient outcomes.
C1 [Mirzabeigi, Michael N.; Wilson, Anthony J.; Fischer, John P.; Basta, Marten; Kanchwala, Suhail; Kovach, Stephen J.; Serletti, Joseph M.; Wu, Liza C.] Univ Penn Hlth Syst, Div Plast Surg, Philadelphia, PA USA.
C3 University of Pennsylvania
RP Wu, LC (通讯作者)，Div Plast Surg, 10 Penn Tower 3400 Spruce St, Philadelphia, PA 19104 USA.
EM liza.wu@uphs.upenn.edu
RI Basta, Marten/I-8953-2019
OI Basta, Marten/0000-0002-9937-5886
CR Bajaj AK, 2006, PLAST RECONSTR SURG, V117, P737, DOI 10.1097/01.prs.0000200062.97265.fb
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   Fischer JP, 2013, PLAST RECONSTR SURG, V132, P750, DOI 10.1097/PRS.0b013e31829fe33c
   Fischer JP, 2013, J AM COLL SURGEONS, V217, P656, DOI 10.1016/j.jamcollsurg.2013.03.031
   Fischer JP, 2013, PLAST RECONSTR SURG, V131, p681E, DOI 10.1097/PRS.0b013e31828e2159
   Futter CM, 2000, BRIT J PLAST SURG, V53, P578, DOI 10.1054/bjps.2000.3427
   Gill PS, 2004, PLAST RECONSTR SURG, V113, P1153, DOI 10.1097/01.PRS.0000110328.47206.50
   Jandali S, 2011, PLAST RECONSTR SURG, V127, P2206, DOI 10.1097/PRS.0b013e3182131c93
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   Munhoz AM, 2005, PLAST RECONSTR SURG, V116, P1881, DOI 10.1097/01.prs.0000191186.20698.0d
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   Salgarello M, 2012, AESTHET PLAST SURG, V36, P363, DOI 10.1007/s00266-011-9804-y
   Selber JC, 2008, PLAST RECONSTR SURG, V122, P348, DOI 10.1097/PRS.0b013e31817d60b0
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   Selber JC, 2009, PLAST RECONSTR SURG, V124, P1015, DOI 10.1097/PRS.0b013e3181b453fd
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   Suominen S, 1997, ANN PLAS SURG, V39, P229, DOI 10.1097/00000637-199709000-00002
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   Wu LC, 2008, PLAST RECONSTR SURG, V122, P702, DOI 10.1097/PRS.0b013e3181823c15
NR 36
TC 26
Z9 29
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2015
VL 135
IS 1
BP 14
EP 23
DI 10.1097/PRS.0000000000000805
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AX4OG
UT WOS:000346911000044
PM 25539292
DA 2026-07-24
ER

PT J
AU Riza, SM
   Porosnicu, AL
   Cepi, PA
   Parasca, SV
   Sinescu, RD
AF Riza, Stefania-Mihaela
   Porosnicu, Andrei-Ludovic
   Cepi, Patricia-Alina
   Parasca, Sorin Viorel
   Sinescu, Ruxandra-Diana
TI Integrating Regenerative Medicine in Chronic Wound Management: A
   Single-Center Experience
SO BIOMEDICINES
LA English
DT Article
DE chronic wounds; platelet-rich plasma (PRP); autologous fat grafting;
   regenerative medicine; adipose-derived stem cells (ADSCs); skin
   grafting; wound healing
ID PLATELET-RICH PLASMA; PATHOGENESIS; INFECTION; GUIDELINE; SCAFFOLDS
AB Background: Chronic wounds represent a persistent clinical challenge and impose a considerable burden on healthcare systems. These lesions often require multidisciplinary management due to underlying factors such as microbial colonization, impaired immunity, and vascular insufficiencies. Regenerative therapies, particularly autologous approaches, have emerged as promising strategies to enhance wound healing. Adipose tissue-derived stem cells (ADSCs) and platelet-rich plasma (PRP) may improve outcomes through paracrine effects and growth factor release. Methods: A prospective observational study was conducted on 31 patients with chronic wounds that were unresponsive to conservative treatment for over six weeks. Clinical and photographic evaluations were employed to monitor healing. All patients underwent surgical debridement, with adjunctive interventions-negative pressure wound therapy, grafting, or flaps-applied as needed. PRP infiltration and/or autologous adipose tissue transfer were administered based on wound characteristics. Wound area reduction was the primary outcome measure. Results: The cohort included 17 males and 14 females (mean age: 59 years). Etiologies included venous insufficiency (39%), diabetes mellitus (25%), arterial insufficiency (16%), and trauma (16%). Most lesions (84%) were located on the lower limbs. All patients received PRP therapy; five underwent combined PRP and fat grafting. Over the study period, 64% of the patients exhibited >80% wound area reduction, with complete healing in 48.3% and a mean healing time of 49 days. Conclusions: PRP therapy proved to be a safe, effective, and adaptable treatment, promoting substantial healing in chronic wounds. Autologous adipose tissue transfer did not confer additional benefit. PRP may warrant inclusion in national treatment protocols.
C1 [Riza, Stefania-Mihaela; Porosnicu, Andrei-Ludovic; Parasca, Sorin Viorel; Sinescu, Ruxandra-Diana] Univ Med & Pharm Carol Davila, Bucharest Clin Emergency Hosp, Dept 11, Discipline Plast & Reconstruct Surg, Bucharest 050474, Romania.
   [Riza, Stefania-Mihaela; Porosnicu, Andrei-Ludovic; Cepi, Patricia-Alina; Sinescu, Ruxandra-Diana] Elias Emergency Univ Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest 011461, Romania.
   [Parasca, Sorin Viorel] Emergency Clin Hosp Plast Reconstruct Surg & Burns, 218 Grivitei St, Bucharest 010713, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Porosnicu, AL (通讯作者)，Univ Med & Pharm Carol Davila, Bucharest Clin Emergency Hosp, Dept 11, Discipline Plast & Reconstruct Surg, Bucharest 050474, Romania.; Porosnicu, AL (通讯作者)，Elias Emergency Univ Hosp, Dept Plast Surg & Reconstruct Microsurg, Bucharest 011461, Romania.
EM stefania-mihaela.riza@drd.umfcd.ro; andrei.porosnicu@umfcd.ro;
   cepipatricia@gmail.com; sorin.parasca@umfcd.ro;
   ruxandra.sinescu@umfcd.ro
RI Parasca, Sorin Viorel/AAB-1739-2021; Sinescu, Ruxana
   Diana/ABD-2479-2020; Riza, Stefania/MDT-6082-2025; Porosnicu, Andrei
   Ludovic/PXW-4532-2026
OI Parasca, Sorin Viorel/0000-0003-3986-0385; Sinescu, Ruxana
   Diana/0000-0002-7591-0987; 
FU University of Medicine and Pharmacy Carol Davila
FX Publication of this paper was supported by the University of Medicine
   and Pharmacy Carol Davila through the institutional program "Publish not
   Perish".
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NR 65
TC 9
Z9 9
U1 3
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL 25
PY 2025
VL 13
IS 8
AR 1827
DI 10.3390/biomedicines13081827
PG 21
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 6QT3A
UT WOS:001559772800001
PM 40868082
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU De Marco, R
   Nasto, LA
   Strangio, A
   Piatelli, G
   Pavanello, M
AF De Marco, Raffaele
   Nasto, Luigi Aurelio
   Strangio, Antonio
   Piatelli, Gianluca
   Pavanello, Marco
TI Surgical limits, pitfalls, and potential solutions in kyphectomy in
   myelomeningocele: three cases and systematic review of the literature
SO CHILDS NERVOUS SYSTEM
LA English
DT Review
DE Kyphosis; Myelomeningocele; Kyphectomy; Spinal deformity; NPWT (negative
   pressure wound therapy)
ID SPINAL-CORD TRANSECTION; LONG-TERM; CONGENITAL KYPHOSIS; LUMBAR
   KYPHOSIS; NATURAL-HISTORY; LUQUE INSTRUMENTATION; KYPHOTIC DEFORMITY;
   TISSUE EXPANSION; CHILDREN; FIXATION
AB ObjectivesTo describe surgical treatment of 3 cases of severe and progressive thoracolumbar kyphosis in myelomeningocele and provide a systematic review of the available literature on the topic.MethodsMedical records and pre- and post-operative imaging of 3 patients with thoracolumbar kyphosis and myelomeningocele were reviewed. A database search was performed for all manuscripts published on kyphectomy and/or surgical treatment of kyphosis in myelomeningocele. Patients' information, preoperative kyphosis angle, type of surgery, levels of surgery degrees of correction after surgery and at follow-up, and complications were reviewed for the included studies.ResultsThree cases underwent posterior vertebral column resection (pVCR) of 2-4 segments at the apex of the kyphosis (kyphectomy). Long instrumentation was performed with all pedicle screws constructed from the thoracic spine to the pelvis using iliac screws. According to literature review, a total of 586 children were treated for vertebral kyphosis related to myelomeningocele. At least one vertebra was excised to gain some degree of correction of the deformity. Different types of instrumentation were used over time and none of them demonstrated to be superior over the other.ConclusionSurgical treatment of progressive kyphosis in myelomeningocele has evolved over the years incorporating all major advances in spinal instrumentation techniques. Certainly, the best results in terms of preservation of correction after surgery and less revision rates were obtained with long construct and screws. However, complication rate remains high with skin problems being the most common complication. The use of low-profile instrumentation remains critical for treatment of these patients.
C1 [De Marco, Raffaele; Strangio, Antonio] Univ Turin, Dept Neurosci R Levi Montalcini, Turin, Italy.
   [Nasto, Luigi Aurelio] Univ Luigi Vanvitelli, Azienda Osped, Naples, Italy.
   [Piatelli, Gianluca; Pavanello, Marco] IRCCS Ist G Gaslini, Dept Neurosurg, Via G Gaslini 5, I-16148 Genoa, Italy.
C3 University of Turin; Universita della Campania Vanvitelli; University of
   Genoa; IRCCS Istituto Giannina Gaslini
RP De Marco, R (通讯作者)，Univ Turin, Dept Neurosci R Levi Montalcini, Turin, Italy.
EM raffaele.demarco@unito.it
RI Marco, Pavanello/K-2859-2019; Nasto, Luigi/AAA-8197-2020; De Marco,
   Raffaele/MHR-8528-2025; Piatelli, Gianluca/ABG-1045-2020
OI De Marco, Raffaele/0000-0001-5187-4689; 
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NR 70
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD MAY
PY 2024
VL 40
IS 5
BP 1541
EP 1569
DI 10.1007/s00381-024-06341-8
EA MAR 2024
PG 29
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA OA5X9
UT WOS:001177346500001
PM 38459148
DA 2026-07-24
ER

PT J
AU Ching, AH
   Hong, QE
   Chew, KY
   Tan, BK
AF Ching, Ann-Hui
   Hong, Qi-En
   Chew, Khong-Yik
   Tan, Bien-Keem
TI Maximizing Micrograft Take in Extensive Back Burns
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
AB Extensive burns involving the back pose unique challenges. Offloading in the prone position is not possible with concomitant deep facial and neck burns. We describe our experience in maximizing graft take in a patient who had extensive back burns with concomitant anterior body burns. The two main goals in graft fixation for extensive back wounds are mechanical stabilization of micrografts to reduce shearing and prevention of water logging from exudates or bleeding to optimize contact with wound bed. Guided by the stages of wound healing, graft take, and burn care, we describe three stages of postoperative negative pressure wound therapy (NPWT) in a patient with 54% TBSA burns treated with micrografting. After complete excision of the deep dermal burns of the entire back, the wounds were covered with micrograft-allograft composites. In phase I, days 1 to 3, conventional topical negative pressure dressing with a thin sponge was applied and a leak-proof seal was achieved with gel sealant and high tack adhesive drapes. In phase II, days 4 to 5, foam dressings with topical negative pressure were applied, but with a less stringent seal, supported by wall suction. In phase III, the selective removal of allografts was initiated to facilitate expansion of micrografts. Negative pressure was continued for another 2 weeks at the most dependent site to prevent wound maceration from exudates. Micrograft take was optimized with the patient in the supine/semirecumbent position. The back wounds healed completely between 60 and 70 days without repeat micrografting. Since prone positioning was not possible in this patient, clearance of exudates and maintenance of micrograft contact with the wound bed using this technique proved successful.
C1 [Ching, Ann-Hui; Hong, Qi-En; Chew, Khong-Yik; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@gmail.com
OI Ching, Ann Hui/0000-0001-5074-7821
FU SingHealth Medical Student Talent Development Award
FX SingHealth Medical Student Talent Development Award (SMSTDA) 2021 2nd
   Cycle.
CR [Anonymous], SKIN
   Chong SJ, 2017, BURNS, V43, P983, DOI 10.1016/j.burns.2017.01.030
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
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   Yin YC, 2018, INT J SURG, V50, P43, DOI 10.1016/j.ijsu.2017.12.020
NR 9
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD NOV 2
PY 2022
VL 43
IS 6
BP 1449
EP 1452
DI 10.1093/jbcr/irac130
EA SEP 2022
PG 4
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 5W2SX
UT WOS:000853926800001
PM 36053550
DA 2026-07-24
ER

PT J
AU Fung, S
   Ashmawy, H
   Krieglstein, C
   Halama, T
   Schilawa, D
   Fuckert, O
   Hees, A
   Kröpil, F
   Rehders, A
   Lehwald-Tywuschik, NC
   Knoefel, WT
AF Fung, Stephen
   Ashmawy, Hany
   Krieglstein, Christian
   Halama, Thomas
   Schilawa, Dustin
   Fuckert, Oliver
   Hees, Anita
   Kroepil, Feride
   Rehders, Alexander
   Lehwald-Tywuschik, Nadja C.
   Knoefel, Wolfram Trudo
TI Vertical traction device prevents abdominal wall retraction and
   facilitates early primary fascial closure of septic and non-septic open
   abdomen
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Vertical traction; Open abdomen; Retraction prevention; Fasciotens
ID ASSISTED WOUND CLOSURE; COMPARTMENT SYNDROME; SECONDARY PERITONITIS;
   VACUUM; MANAGEMENT; THERAPY; TRAUMA
AB Purpose One of the major challenges in the management of patients with septic and non-septic open abdomen (OA) is to control abdominal wall retraction. The aim of this study was to evaluate the impact of a novel vertical traction device (VTD) on primary fascial closure (PFC) and prevention of fascial retraction. Methods Twenty patients treated with OA were included in this retrospective multicenter study. All patients were initially stabilized with laparostomy and the abdomen temporarily sealed either with a Bogota bag or a negative pressure wound therapy system (NPWT). Results The mean duration of OA and fascia-to-fascia distance (FTF) prior to the VTD application were 3 days and 15 cm, respectively. At relook laparotomy 48 h after VTD implementation, the mean FTF distance significantly decreased to 10 cm (p = 0.0081). In all cases, PFC was achieved after a mean period of 7 days. Twelve patients received the VTD in combination with a NPWT, whereas in eight patients, the device was combined with an alternative temporary abdominal closure system (TAC). Although not statistically significant, the FTF distance remarkably decreased in both groups at relook laparotomy 48 h following the device implementation. The mean periods of PFC for patients with septic and non-septic OA were comparable (7.5 vs. 7 days). During follow-up, two patients developed an incisional hernia. Conclusion Vertical traction device prevents fascial retraction and facilitates early PFC in OA. In combination with NPWT, rapid fascial closure of large abdominal defects can be achieved.
C1 [Fung, Stephen; Ashmawy, Hany; Kroepil, Feride; Rehders, Alexander; Lehwald-Tywuschik, Nadja C.; Knoefel, Wolfram Trudo] Heinrich Heine Univ, Dept Surg A, Moorenstr 5, D-40225 Moorenstrasse, Germany.
   [Fung, Stephen; Ashmawy, Hany; Kroepil, Feride; Rehders, Alexander; Lehwald-Tywuschik, Nadja C.; Knoefel, Wolfram Trudo] Univ Hosp Duesseldorf, Moorenstr 5, D-40225 Moorenstrasse, Germany.
   [Krieglstein, Christian] St Elisabeth Krankenhaus Koln, Dept Surg, Werthmannstr 1, D-50935 Cologne, Germany.
   [Halama, Thomas] St Vinzenz Hosp, Dept Surg, Merheimer Str 221-223, D-50733 Cologne, Germany.
   [Schilawa, Dustin] St Rochus Krankenhaus, Dept Surg, Gluckaufstr 10, D-44575 Castrop Rauxel, Germany.
   [Fuckert, Oliver] Lukas Krankenhaus, Dept Surg, Hindenburgstr 56, D-32257 Bunde, Germany.
   [Hees, Anita] St Marien Krankenhaus, Dept Surg, Kampenstr 51, D-57072 Siegen, Germany.
C3 Heinrich Heine University Dusseldorf; St. Marien Hospital
RP Fung, S (通讯作者)，Heinrich Heine Univ, Dept Surg A, Moorenstr 5, D-40225 Moorenstrasse, Germany.; Fung, S (通讯作者)，Univ Hosp Duesseldorf, Moorenstr 5, D-40225 Moorenstrasse, Germany.
EM stephen.fung@med.uni-duesseldorf.de; knoefel@hhu.de
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 33
TC 14
Z9 18
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD AUG
PY 2022
VL 407
IS 5
BP 2075
EP 2083
DI 10.1007/s00423-021-02424-1
EA FEB 2022
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3Y1TV
UT WOS:000754150600001
PM 35147749
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Zhang, N
   Yu, X
   Zhang, K
   Liu, TJ
AF Zhang, Nan
   Yu, Xin
   Zhang, Kai
   Liu, Tongjun
TI A retrospective case series of Fournier's gangrene: necrotizing
   fasciitis in perineum and perianal region
SO BMC SURGERY
LA English
DT Article
DE Fournier&#8217; s gangrene; Necrotizing fasciitis; Infection
ID LABORATORY RISK INDICATOR
AB Background To describe the clinical characteristics and management for Fournier's gangrene. Experience summary and literature references are provided for future treatment improvement. Methods We retrospectively reviewed the cases diagnosed with Fournier's gangrene in our department from June 2016 to June 2019. Clinical data, including manifestation, diagnosis, treatment and outcomes for Fournier's gangrene were presented. Results There were 12 patients enrolled in this paper, with the average age of 60 years old. It showed a male predominance with male-to-female ratio of 6:1. The average of laboratory risk indicator for necrotizing fasciitis (LRINEC) score was 10.1. Diabetes mellitus was the main predisposing disease. 11 patients received emergency debridement and 1 patient died of sepsis on the 2nd day after admission. The mortality rate was 8.3%. 6 cases developed complications, including sepsis, pneumonia, renal and heart failure. Negative pressure wound therapy (NPWT) was applied in 10 cases, while the rest 1 received normal daily dressing changes because of fecal contamination. Flaps were utilized in 2 patients to cover the defect, including one with advancement flap and one with pudendal-thigh flap, while others received secondary suture, secondary healing, skin graft or combined management. No relapse was observed during the follow-up visits. Conclusions Fournier's gangrene is a life-threatening infection that requires early diagnosis and surgery intervention. The predisposing disease, clinical manifestation and LRINEC score should be taken into comprehensive consideration, which is helpful for timely diagnosis. Moreover, further successful treatment depends on the aggressive debridement, broad-spectrum antibiotics therapy, wound management and closure choice.
C1 [Zhang, Nan; Zhang, Kai; Liu, Tongjun] Jilin Univ Second Hosp, Gen Surg, 218 ZiQiang St, Changchun 130000, Peoples R China.
   [Yu, Xin] Jilin Univ First Hosp, Dept Pediat, 71 Xinmin St, Changchun, Peoples R China.
RP Liu, TJ (通讯作者)，Jilin Univ Second Hosp, Gen Surg, 218 ZiQiang St, Changchun 130000, Peoples R China.
EM tongjunliu@sina.cn
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NR 21
TC 32
Z9 47
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD OCT 30
PY 2020
VL 20
IS 1
AR 259
DI 10.1186/s12893-020-00916-3
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OP3MR
UT WOS:000587986700001
PM 33126879
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gilligan, AM
   Waycaster, CR
   Bizier, R
   Chu, BC
   Carter, MJ
   Fife, CE
AF Gilligan, Adrienne M.
   Waycaster, Curtis R.
   Bizier, Richard
   Chu, Bong-Chul
   Carter, Marissa J.
   Fife, Caroline E.
TI Comparative Effectiveness of Clostridial Collagenase Ointment to
   Medicinal Honey for Treatment of Pressure Ulcers
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE pressure ulcer; debridement; granulation; epithelialization; clostridial
   collagenase ointment; medicinal honey
ID WOUND DEBRIDEMENT; COST-EFFECTIVENESS; PREVENTION
AB Objective: Compare enzymatic debridement using clostridial collagenase ointment (CCO) with autolytic debridement using medicinal honey in the hospital outpatient setting for treating pressure ulcers (PUs).
   Approach: Retrospective deidentified electronic health records from 2007-2013 were extracted from the U.S. Wound Registry. Propensity score matching followed by multivariable analyses was used to adjust for selection bias and assess treatment effects comparing CCO-treated versus honey-treated PUs. Key outcomes included 100% granulation and epithelialization at 1 year.
   Results: Five hundred seventeen CCO-treated PUs (446 patients) were matched to corresponding honey-treated PUs (341 patients). The majority of PUs were stage III (CCO 56%, honey 55%). CCO users had significantly fewer total visits (9.1 vs. 12.6; p<0.001), fewer total selective sharp debridements (2.7 vs. 4.4; p<0.001), and fewer PUs receiving negative pressure wound therapy (29% vs. 38%; p=0.002) compared with honey.
   Innovation: CCO-treated PUs were 38% more likely to achieve 100% granulation compared to honey-treated PUs at 1 year, p=0.018. Mean days to 100% granulation were significantly lower for CCO-treated PUs (255 vs. 282 days, p<0.001). CCO-treated PUs were 47% (p=0.024) more likely to epithelialize at 1 year compared to PUs treated with honey. Mean days to epithelialization were significantly lower for PUs treated with CCO at 1 year (288 vs. 308 days; p=0.011).
   Conclusion: All stages of PUs treated with CCO achieved faster rates of granulation and subsequent epithelialization compared to PUs treated with medicinal honey as measured by real-world data collected in the hospital outpatient department care setting.
C1 [Gilligan, Adrienne M.] Truven Hlth Analyt, Houston, TX USA.
   [Waycaster, Curtis R.] Smith & Nephew, Ft Worth, TX USA.
   [Bizier, Richard] Truven Hlth Analyt, Cambridge, MA USA.
   [Chu, Bong-Chul] Truven Hlth Analyt, Santa Barbara, CA USA.
   [Carter, Marissa J.] Strateg Solut Inc, Cody, WY USA.
   [Fife, Caroline E.] Intellicure Inc, The Woodlands, TX USA.
C3 Smith & Nephew
RP Gilligan, AM (通讯作者)，IBM Co, Truven Hlth Analyt, 2 Riverway 200, Houston, TX 77056 USA.
EM agilligan@us.ibm.com
FU Smith & Nephew, Fort Worth, TX
FX Editorial/ medical writing support for this article was provided by Jay
   Margolis, PharmD (Truven Health Analytics). This study was sponsored by
   Smith & Nephew, Fort Worth, TX.
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NR 44
TC 13
Z9 17
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD APR
PY 2017
VL 6
IS 4
BP 125
EP 134
DI 10.1089/wound.2016.0720
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ER4ZD
UT WOS:000398810100003
PM 28451469
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Loftus, TJ
   Jordan, JR
   Croft, CA
   Smith, RS
   Efron, PA
   Moore, FA
   Mohr, AM
   Brakenridge, SC
AF Loftus, Tyler J.
   Jordan, Janeen R.
   Croft, Chasen A.
   Smith, R. Stephen
   Efron, Philip A.
   Moore, Frederick A.
   Mohr, Alicia M.
   Brakenridge, Scott C.
TI Emergent laparotomy and temporary abdominal closure for the cirrhotic
   patient
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 36th Annual Meeting of the Surgical-Infection-Society (SIS)
CY MAY 17-21, 2016
CL Palm Beach, FL
SP Surg Infect Soc
DE Temporary abdominal closure; Damage control surgery; Laparotomy; Open
   abdomen; Cirrhosis; Ascites
ID OPEN ABDOMEN; HEMODYNAMIC CONSEQUENCES; DAMAGE-CONTROL; MANAGEMENT;
   COAGULOPATHY; TRAUMA; FAILURE; BICARBONATE; PREDICTORS; MORBIDITY
AB Background: Temporary abdominal closure (TAC) may be performed for cirrhotic patients undergoing emergent laparotomy. The effects of cirrhosis on physiologic parameters, resuscitation requirements, and outcomes following TAC are unknown. We hypothesized that cirrhotic TAC patients would have different resuscitation requirements and worse outcomes than noncirrhotic patients.
   Methods: We performed a 3-year retrospective cohort analysis of 231 patients managed with TAC following emergent laparotomy for sepsis, trauma, or abdominal compartment syndrome. All patients were initially managed with negative pressure wound therapy (NPWT) TAC with intention for planned relaparotomy and sequential abdominal closure attempts at 24- to 48-h intervals.
   Results: At presentation, cirrhotic patients had higher incidence of acidosis (33% versus 17%) and coagulopathy (87% versus 54%) than noncirrhotic patients. Forty-eight hours after presentation, cirrhotic patients had a persistently higher incidence of coagulopathy (77% versus 44%) despite receiving more fresh frozen plasma (10.8 units versus 4.4 units). Cirrhotic patients had higher NPWT output (4427 mL versus 2375 mL) and developed higher vasopressor infusion rates (57% versus 29%). Cirrhotic patients had fewer intensive care unit-free days (2.3 versus 7.6 days) and higher rates of multiple organ failure (64% versus 34%), in-hospital mortality (67% versus 21%), and long-term mortality (80% versus 34%) than noncirrhotic patients.
   Conclusions: Cirrhotic patients managed with TAC are susceptible to early acidosis, persistent coagulopathy, large NPWT fluid losses, prolonged vasopressor requirements, multiple organ failure, and early mortality. Future research should seek to determine whether TAC provides an advantage over primary fascial closure for cirrhotic patients undergoing emergency laparotomy. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Loftus, Tyler J.; Jordan, Janeen R.; Croft, Chasen A.; Smith, R. Stephen; Efron, Philip A.; Moore, Frederick A.; Mohr, Alicia M.; Brakenridge, Scott C.] Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Dept Surg, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Brakenridge, SC (通讯作者)，Univ Florida Hlth, Sepsis & Crit Illness Res Ctr, Dept Surg, 1600 SW Archer Rd,Room M-602, Gainesville, FL 32610 USA.
EM Scott.Brakenridge@surgery.ufl.edu
RI Mohr, Alicia/E-3016-2015; Loftus, Tyler/J-7761-2016; Brakenridge,
   Scott/AAD-6691-2019
OI Mohr, Alicia/0000-0003-1732-1313; Loftus, Tyler/0000-0001-5354-443X;
   Brakenridge, Scott/0000-0002-7327-3718; Smith,
   Robert/0000-0002-0455-6415
FU National Institute on Aging; National Institute of General Medical
   Sciences (NIGMS); postgraduate training grant in burns, trauma [T32
   GM-08721]; NIGMS;  [P30 AG028740];  [R01 GM105893-01A1];  [R01
   GM113945-01];  [P50 GM111152-01]; National Institute of General Medical
   Sciences [T32GM008721, R01GM105893] Funding Source: NIH RePORTER;
   National Institute on Aging [P30AG028740] Funding Source: NIH RePORTER
FX The authors acknowledge Cindy Scalamonti, CSTR for her assistance in
   maintaining, accessing, and assuring the quality of our institutional
   data registry. T.J.L. contributed to study design, data collection, data
   analysis, data interpretation, and manuscript composition. J.R.J.,
   C.A.C., R.S.S., and P.A.E. contributed to data interpretation and
   provided critical revisions. F.A.M., A.M.M., and S.C.B. contributed to
   study design, data interpretation, and provided critical revisions. The
   authors were supported in part by grants P30 AG028740 (S.C.B.) awarded
   by the National Institute on Aging and by R01 GM105893-01A1 (A.M.M.),
   R01 GM113945-01 (P.A.E.), and P50 GM111152-01 (S.C.B., F.A.M., A.M.M.,
   and P.A.E.) awarded by the National Institute of General Medical
   Sciences (NIGMS). T.J.L. was supported by a postgraduate training grant
   (T32 GM-08721) in burns, trauma, and perioperative injury by NIGMS.
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NR 43
TC 3
Z9 3
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2017
VL 210
BP 108
EP 114
DI 10.1016/j.jss.2016.11.013
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EU6DU
UT WOS:000401125000013
PM 28457316
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Islam, I
   Dey, P
   Thalluri, C
AF Islam, Injamul
   Dey, Piyali
   Thalluri, Chandrashekar
TI Therapeutic strategies to enhance proliferation in diabetic wound
   contraction: a comprehensive review from 1991-2025
SO ACTA DIABETOLOGICA
LA English
DT Review; Early Access
DE Diabetic wound; Wound contraction; Modern technology; Complimentary
   approach; Proliferation; Experimental model
ID HYPERBARIC-OXYGEN THERAPY; GROWTH-FACTOR; FOOT ULCERS; MYOFIBROBLAST;
   FORMULATIONS; MEMBRANES; DELIVERY; PHASE
AB The global rise in diabetes mellitus has been accompanied by a marked increase in associated complications, most notably impaired wound healing. Diabetic non-healing wounds arise from multifactorial pathophysiological mechanisms, including excessive and prolonged inflammation, immune dysregulation, impaired angiogenesis, defective fibroblast-to-myofibroblast transition and aberrant growth factor signaling. These abnormalities delay wound contraction and re-epithelialization, increasing susceptibility to infection, chronic ulceration and limb amputation. Traditional and complementary approaches such as herbal formulations, Ayurvedic practices, and natural bioactive compounds have demonstrated potential in mitigating oxidative stress, modulating inflammation and promoting neovascularization. In parallel, advanced technological interventions, including nanocomposite hydrogels, smart and responsive biomaterials, gene therapy and targeted growth factor delivery systems, are being developed to create a pro-regenerative wound microenvironment. Modern clinical strategies such as electromagnetic therapy, negative pressure wound therapy, electrospun nanofiber scaffolds and 3D/4D bioprinting further contribute to enhanced wound contraction and tissue regeneration. Additionally, bioengineered skin substitutes, stem cell-based therapies and innovative growth factor delivery platforms offer promising translational prospects. This review critically summarizes traditional, complementary, and innovative approaches reported up to 2025, with an emphasis on smart biomaterials, emerging therapies and relevant preclinical models, highlighting future directions for improving diabetic wound care and patient quality of life.Graphical abstractIllustration of impaired wound healing under diabetic conditions and the coordinated contribution of complementary and advanced therapeutic strategies to enhance wound contraction. Diabetes-associated oxidative stress, chronic inflammation and growth factor dysregulation delay tissue repair, whereas smart biomaterials, growth factor-based therapies, nanotherapeutics, bioprinting, exosome-loaded systems and adjunct physical therapies promote angiogenesis, extracellular matrix remodeling, re-epithelialization and accelerated wound closure.
C1 [Islam, Injamul; Dey, Piyali; Thalluri, Chandrashekar] Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
RP Dey, P (通讯作者)，Assam Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
EM piyali.drl@gmail.com
RI Shekar, Chandra/LKK-6483-2024
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NR 143
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD 2026 JUN 23
PY 2026
DI 10.1007/s00592-026-02728-y
EA JUN 2026
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JX0XL
UT WOS:001800026800001
PM 42334597
DA 2026-07-24
ER

PT J
AU Findeisen, A
   Arefian, H
   Doenst, T
   Hagel, S
   Pletz, MW
   Hartmann, M
   Maschmann, J
AF Findeisen, Axel
   Arefian, Habibollah
   Doenst, Torsten
   Hagel, Stefan
   Pletz, Mathias W.
   Hartmann, Michael
   Maschmann, Jens
TI Economic burden of surgical site infections in patients undergoing
   cardiac surgery
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the German-Society-for-Health Economics (DGGO)
CY MAR 05-06, 2018
CL Hamburg, GERMANY
SP German Soc Hlth Econ
DE Cost; Surgical site infection; Cardiac surgery; Length of stay
ID LENGTH-OF-STAY; CARE-ASSOCIATED INFECTIONS; COST
AB OBJECTIVES This study aimed to determine the additional costs and length of stay (LOS) due to surgical site infections (SSIs) after coronary artery bypass grafting (CABG) at Jena University Hospital.
   METHODS The data of 999 consecutive patients who underwent CABG from January 2013 to December 2014 were collected. We extracted the number, type and duration of antimicrobial therapy and V.A.C.((R)) therapy (negative pressure wound therapy) treatments and calculated the additional SSI-related costs based on the hospital's perspective. We also evaluated the prolongation of LOS using a multistate model and calculated the costs due to the additional LOS.
   RESULTS In total, 983 patients were included in our analysis, and 126 patients with SSIs following CABG were identified during the study period; 124 patients with SSIs (98.4%) were discharged alive. The mean cost of antimicrobial therapy to treat the SSIs was Euro818 [95% confidence interval (CI) 392-1245], and the mean cost of V.A.C. therapy was Euro1179 (95% CI 748-1610) per infected patient. The mean additional LOS due to SSIs (standard error) was estimated to be 9.3 +/- 2.6days. The cost per SSI-infected patient attributable to the additional LOS was Euro9444 (95% CI 4242-14645).
   CONCLUSIONS SSIs following CABG are associated with an additional LOS and a significant economic burden depending on the classification of SSI. A very important component of the additional cost is the prolongation of LOS. Therefore, it is essential to shorten the hospital stay due to SSIs as far as possible.
C1 [Findeisen, Axel] Friedrich Schiller Univ Jena, Fac Med, Jena, Germany.
   [Arefian, Habibollah; Hagel, Stefan; Hartmann, Michael] Jena Univ Hosp, CSCC, Jena, Germany.
   [Arefian, Habibollah; Hartmann, Michael] Jena Univ Hosp, Hosp Pharm, Jena, Germany.
   [Doenst, Torsten] Jena Univ Hosp, Dept Cardiothorac Surg, Klinikum 1, D-07747 Jena, Germany.
   [Hagel, Stefan; Pletz, Mathias W.] Jena Univ Hosp, Inst Infect Dis & Infect Control, Jena, Germany.
   [Maschmann, Jens] Jena Univ Hosp, Jena, Germany.
C3 Friedrich Schiller University of Jena; Friedrich Schiller University of
   Jena; Friedrich Schiller University of Jena; Friedrich Schiller
   University of Jena; Friedrich Schiller University of Jena; Friedrich
   Schiller University of Jena
RP Doenst, T (通讯作者)，Jena Univ Hosp, Dept Cardiothorac Surg, Klinikum 1, D-07747 Jena, Germany.
EM doenst@med.uni-jena.de
RI Hartmann, Michael/Y-2331-2019; Arefian, Habib/AAK-3701-2020; Pletz,
   Mathias/H-9782-2019; Hagel, Stefan/AAE-1174-2022
OI Hartmann, Michael/0000-0002-6777-4540; Arefian,
   Habib/0000-0002-8838-084X; Pletz, Mathias/0000-0001-8157-2753; Hagel,
   Stefan/0000-0003-2999-6131
FU German Ministry of Education and Research (BMBF) [01EO1502]; German
   Ministry for Education and Research [01 KI 1501]
FX The Center for Sepsis Control and Care was supported by the German
   Ministry of Education and Research (BMBF) [01EO1502]; and the German
   Ministry for Education and Research [01 KI 1501 to M.B. and S.H.].
CR Allignol A, 2011, J STAT SOFTW, V38, P1
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NR 25
TC 27
Z9 35
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAR
PY 2019
VL 55
IS 3
BP 494
EP 500
DI 10.1093/ejcts/ezy274
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA HQ9BJ
UT WOS:000462721200017
PM 30084908
OA Bronze
DA 2026-07-24
ER

PT J
AU Schniewind, B
   Schafmayer, C
   von Schönfels, W
   Heits, NG
   Kucharzik, T
   Klein, G
   Hampe, J
AF Schniewind, Bodo
   Schafmayer, Clemens
   von Schoenfels, Witigo
   Heits, Nils G.
   Kucharzik, Torsten
   Klein, Georg
   Hampe, Jochen
TI Treatment of Complicated Anal Fistula by an Endofistular
   Polyurethane-Sponge Vacuum Therapy: A Pilot Study
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Anal fistula; Crohn's disease; Cryptoglandular fistula; Endoluminal
   polyurethane sponge; Endoluminal vacuum therapy; Negative pressure wound
   therapy
ID IN-ANO; CROHNS; MANAGEMENT; SURGERY; LEAKAGE
AB BACKGROUND: Treatment of supra- and transsphincteric anal fistulas remains a clinical challenge because current treatment results are variable and potentially endanger sphincter function.
   OBJECTIVE: Based on positive results of endoluminal polyurethane-sponge vacuum therapy in the upper and lower GI tract, a new system for endofistular vacuum therapy was developed for anal fistulas to utilize vacuum therapy to remove the endofistular pseudoepithelium and to induce granulation in the fistula tract.
   DESIGN: This study is based on a prospective case series.
   PATIENTS: Seven patients with complicated anal fistulas (3 associated with Crohn's disease and 4 of cryptoglandular origin) longer than 4cm were treated. Initially, the fistula was curettaged and the first endofistular vacuum therapy sponge was positioned in the fistula tract. The inner fistula opening was closed by suture. A 125mm Hg constant vacuum was applied to the sponge, and the endofistular vacuum therapy sponge was changed a median of 3 (3-5) times after each 48 to 72 hours of constant vacuum therapy. After final removal, the fistulas were reevaluated every other week for 3 months.
   MAIN OUTCOME MEASURE: The main outcome measured was the closure of the fistula.
   RESULTS: All patients tolerated the therapy well and no adverse events were observed. Fistula tract closure was demonstrated within 4 weeks after the termination of vacuum therapy. One patient with cryptoglandular fistula developed a recurrence within the follow-up of 3 months.
   LIMITATIONS: This was an observational study that had no control arm.
   CONCLUSION: In this pilot case series, the results are encouraging. Because endoluminal vacuum therapy would be a new and sphincter-sparing therapy, this concept warrants further investigation in controlled trials.
C1 [Schniewind, Bodo; Klein, Georg] Staedt Krankenhaus, Community Hosp Lueneburg, Dept Gen Visceral & Thorac Surg, Luneburg, Germany.
   [Schafmayer, Clemens; von Schoenfels, Witigo; Heits, Nils G.] Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Visceral & Thorac Surg, Kiel Campus, Kiel, Germany.
   [Schafmayer, Clemens; Kucharzik, Torsten] Staedt Krankenhaus, Community Hosp Lueneburg, Dept Internal Med, Luneburg, Germany.
   [Hampe, Jochen] Tech Univ Dresden, TU Dresden, Univ Hosp Dresden, Med Dept 1, Dresden, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital
RP Schniewind, B (通讯作者)，Staedt Klinikum Lueneburg, Dept Gen Visceral & Thorac Surg, Boegelstr 1, D-21339 Luneburg, Germany.
EM Bodo.Schniewind@klinikum-lueneburg.de
RI /AAL-9780-2020; Hampe, Jochen/A-2555-2010
OI Hampe, Jochen/0000-0002-2421-6127
FU Medical faculty of the University Hospital Schleswig-Holstein/Germany
FX This research was supported by institutional funds from the Medical
   faculty of the University Hospital Schleswig-Holstein/Germany.
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NR 19
TC 2
Z9 4
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD DEC
PY 2018
VL 61
IS 12
BP 1435
EP 1441
DI 10.1097/DCR.0000000000001233
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HA7AC
UT WOS:000450432100018
PM 30399049
DA 2026-07-24
ER

PT J
AU Matiasek, J
   Djedovic, G
   Unger, L
   Beck, H
   Mattesich, M
   Pierer, G
   Koller, R
   Rieger, UM
AF Matiasek, J.
   Djedovic, G.
   Unger, L.
   Beck, H.
   Mattesich, M.
   Pierer, G.
   Koller, R.
   Rieger, U. M.
TI Outcomes for split-thickness skin transplantation in high-risk patients
   using octenidine
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE split-thickness skin graft; octenidine; tie-over dressing; cortisone
   therapy; diabetes mellitus; antiseptic wound management
ID RANDOMIZED CONTROLLED-TRIAL; DOUBLE-BLIND; DIHYDROCHLORIDE;
   COLONIZATION; DISINFECTION; WOUNDS
AB Skin transplantation is a commonly used surgical technique; however, the complication rate, including postoperative infection and delayed wound healing due to inefficient perfusion, is significantly higher in patients suffering from comorbidities. Hence, a subsequent repeat procedure is often necessary. In this report, two case studies are presented in which an octenidine-based antiseptic is used with a tie-over dressing (TOD) instead of povidone iodine (PVP-iodine), following a split-thickness skin graft. The two patients selected were deemed to be at high risk of impaired wound healing due to comorbidities. The first patient, a confirmed smoker with diabetes, presented with a nodular melanoma that was resected and covered with a split-thickness skin graft. After 5 days of negative pressure wound therapy as a TOD, in combination with PVP-iodine, the graft became necrotic. A second split-thickness skin graft was performed and an antiseptic regimen with octenidine in combination with the same TOD resulted in a completely healed transplant.
   The second patient, also a confirmed smoker with diabetes and receiving oral corticosteroid treatment, was diagnosed with a skin necrosis on her leg. Following the split-thickness skin graft, octenidine and TOD were applied. The patient's skin graft completely healed without any adverse events.
   These two case studies indicate that the combination of octenidine and TOD following split-thickness skin transplantation is safe, well-tolerated and appears to have positive benefits in the reconstruction of defects in patients with impaired wound healing.
C1 [Matiasek, J.; Unger, L.; Beck, H.; Koller, R.] Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
   [Matiasek, J.; Djedovic, G.; Mattesich, M.; Pierer, G.; Rieger, U. M.] Med Univ Innsbruck, Dept Plast Reconstruct & Aesthet Surg, A-6020 Innsbruck, Austria.
   [Djedovic, G.; Rieger, U. M.] St Markus Hosp, Dept Plast & Aesthet Surg, Reconstruct & Hand Surg, Frankfurt, Germany.
C3 Wilhelminenspital; Medical University of Innsbruck
RP Matiasek, J (通讯作者)，Wilhelminenspital Stadt Wien, Dept Plast Aesthet & Reconstruct Surg, Vienna, Austria.
EM johannes.matiasek@me.com
RI Unger, Lukas Walter/I-8768-2019
OI Unger, Lukas Walter/0000-0002-8423-2268
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NR 20
TC 9
Z9 11
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2015
VL 24
IS 6
SU S
BP S8
EP S12
DI 10.12968/jowc.2015.24.Sup6.S8
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CJ8PN
UT WOS:000355765800003
PM 26075514
DA 2026-07-24
ER

PT J
AU Lim, AKH
   De Silva, ML
   Wang, RSH
   Nicholson, AJ
   Rogers, BA
AF Lim, Andy K. H.
   De Silva, Maneesha L.
   Wang, Rene S. H.
   Nicholson, Angus J.
   Rogers, Benjamin A.
TI Observational study of the incidence and factors associated with patient
   readmission from home-based care under the Hospital in the Home
   programme
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE hospital-based home care; Hospital in the Home; hospital readmission;
   risk factors; complications; comorbidity
AB Background Hospital in the Home (HITH) provides home-based care by hospital staff, which reduces inpatient length of stay and promotes a better quality of life. The frequency and precipitants for readmission from HITH back to the acute inpatient service are currently poorly defined. Aims To determine the incidence of hospital readmissions and risk factors for readmissions in a HITH programme of a large hospital network. Methods We conducted a retrospective cohort study of adult patients admitted to a large HITH service within a hospital network in Victoria, Australia, from 1 July to 30 September 2017. We used logistic regression to determine if patient characteristics or specific clinical factors were associated with hospital readmission. Results In a cohort of 605 patients under HITH, 72 were readmitted (incidence 11.9%). The median duration under HITH prior to readmission was 7 days (interquartile range, 3-23 days). Most readmissions were due to treatment failure, an associated complication or new clinical problem. In the univariable analysis, older age, direct admission from the emergency department (ED), recent intensive care admission, high Charlson comorbidity index, advanced chronic kidney disease, negative pressure wound therapy and use of antihypertensives were factors associated with readmission. In the multivariable analysis, the variables independently associated with readmissions were the Charlson comorbidity index (odds ratio, OR 1.17, 95% CI: 1.08-1.25) and referrals from the ED (OR 0.18, 95% CI: 0.06-0.58). Conclusions Older age and greater comorbidity increased the odds of readmission, but patients from the ED were low risk compared to inpatient referrals.
C1 [Lim, Andy K. H.; De Silva, Maneesha L.; Wang, Rene S. H.; Nicholson, Angus J.; Rogers, Benjamin A.] Monash Hlth Gen Med, 246 Clayton Rd, Clayton, Vic 3168, Australia.
   [Lim, Andy K. H.; Rogers, Benjamin A.] Monash Univ, Sch Clin Sci, Dept Med, Melbourne, Vic, Australia.
C3 Monash University
RP Lim, AKH (通讯作者)，Monash Hlth Gen Med, 246 Clayton Rd, Clayton, Vic 3168, Australia.
EM andy.lim@monash.edu
RI Lim, Andy/O-5986-2016; Rogers, Benjamin/J-3309-2012
OI Lim, Andy/0000-0001-7816-4724; Rogers, Benjamin/0000-0002-5322-6375
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NR 13
TC 14
Z9 15
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD SEP
PY 2021
VL 51
IS 9
BP 1497
EP 1504
DI 10.1111/imj.15213
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA US0CG
UT WOS:000697104900019
PM 33474821
DA 2026-07-24
ER

PT J
AU Fearmonti, RM
AF Fearmonti, Regina M.
TI Efficacy of Epidermal Skin Grafts Over Complex, Chronic Wounds in
   Patients With Multiple Comorbidities
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE chronic wounds; skin grafting; epidermal skin grafts; wound healing
ID MINIMALLY INVASIVE TOOL; HARVESTING SYSTEM; MICROGRAFTS; VITILIGO
AB Background. Epidermal skin grafting presents an alternative to traditional autografts since only epidermal skin is harvested from the donor site. Split-thickness skin grafts are associated with difficulties at the donor site, including excessive pain, delayed healing, fluid loss, and unsatisfactory cosmetic results - all exacerbated in patients with comorbidities. A new automated epidermal harvesting tool (CelluTome Epidermal Harvesting System, KCI, an Acelity company, San Antonio, TX) involves concurrent application of heat and suction to normal skin to produce epidermal grafts. This article outlines the author's experience using this automated epidermal harvesting tool to harvest epidermal grafts and apply them on 23 chronic lower extremity wounds of patients with multiple comorbidities. Methods and Materials. Vacuum and heat were applied until epidermal microdomes were formed (30-45 minutes); an epidermal microdome array was collected onto a transfer dressing and applied over the wound. Results. The automated harvesting tool yielded viable epithelium with every use. In addition to the epidermal skin graft, 16 of 23 wounds (70%) received adjunctive wound treatment, including negative pressure wound therapy, hyperbaric oxygen therapy, and/or regenerative tissue matrix. The average reepithelialization rate was 88.1% during a mean follow-up period of 76.4 days; no use of an anesthetic/operating room was required for the procedure. All donor sites were completely healed within 2 weeks without complications or scarring. Conclusion. Epidermal skin grafting provided a simplified, office-based grafting option with no donor site morbidity, and assisted in closure or size reduction of chronic wounds in this series.
C1 [Fearmonti, Regina M.] Alon Aesthet Plast Surg, San Antonio, TX USA.
RP Fearmonti, RM (通讯作者)，Alon Aesthet Plast Surg, San Antonio, TX USA.
EM FearmontiPlasticSurgery@gmail.com
CR [Anonymous], PODIATRY MANAGE
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NR 19
TC 16
Z9 16
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2016
VL 28
IS 7
BP 226
EP 232
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DZ4ZJ
UT WOS:000385870700003
PM 27428717
DA 2026-07-24
ER

PT J
AU Srivastava, AK
   Kummer, KA
   Troop, BR
   Gildehaus, AJ
   Gunn, K
   Davis, G
AF Srivastava, Anil K.
   Kummer, Katherine A.
   Troop, Bryan R.
   Gildehaus, Alison J.
   Gunn, Kulsoom
   Davis, Gina
TI Bio-resorbable poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall
   reconstruction is effective in high-risk patients and contaminated
   abdomen
SO HERNIA
LA English
DT Article
DE Poly-4-hydroxybutyrate mesh; Abdominal wall reconstruction; High-risk
   comorbidities; Contaminated abdomen
ID VENTRAL HERNIA REPAIR; LONG-TERM; SYNTHETIC MESH; BIOLOGIC MESH;
   COMPLICATIONS; MULTICENTER; RECURRENCE; OUTCOMES; COHORT
AB PurposeAbdominal wall reconstruction in patients with high-risk comorbidities and contamination is controversial. There is no standardized mesh choice for such clinical circumstances. We reviewed our experience of poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall reconstruction in hostile abdomen after emergency and elective abdominal surgeries.MethodsWe performed a retrospective review of 48 patients with CDC class 3 or 4 contamination and high-risk comorbidities who underwent abdominal wall reconstruction with P4HB between June 2016-October 2019. Data collected included demographics, abdominal closure techniques, and long-term surgical site complications and hernia recurrence.ResultsPatients ranged from 33-88 years old; 70% were female. BMI ranged from 14-70 kg/m2 (mean 36, SD +/- 11.31). High-risk comorbidities were present in 75% of patients. Emergency abdominal closures were performed in 69% of patients. Underlay Phasix (TM) ST mesh was used in 71% of emergency and 53% of elective abdominal closures. Myofascial release was required in 21% of elective and 9% of emergency patients. Fascial negative pressure wound therapy was used in 45% of emergency and 20% of elective patients. Surgical site occurrences were seen in 42% of emergency and 53% of elective abdominal closures. At a mean follow-up of 41.8 months, hernias had recurred in 16% patients after emergency and 20% after elective procedures.ConclusionP4HB mesh is well tolerated and provides durable abdominal wall reconstruction with acceptable hernia recurrence after emergency and elective abdominal closure, making it a sensible option for abdominal closure in high-risk comorbidities and abdominal contamination.
C1 [Srivastava, Anil K.; Kummer, Katherine A.; Troop, Bryan R.; Gildehaus, Alison J.; Gunn, Kulsoom; Davis, Gina] Mercy Hosp, Dept Surg, Div Trauma & Acute Care Surg, 621 S New Ballas Rd, St Louis, MO 63141 USA.
C3 Saint Johns Mercy Medical Center
RP Srivastava, AK (通讯作者)，Mercy Hosp, Dept Surg, Div Trauma & Acute Care Surg, 621 S New Ballas Rd, St Louis, MO 63141 USA.
EM anil.srivastava@mercy.net
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NR 38
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD OCT 31
PY 2025
VL 30
IS 1
AR 2
DI 10.1007/s10029-025-03497-3
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9IB8F
UT WOS:001606876000003
PM 41171463
DA 2026-07-24
ER

PT J
AU Huang, CH
   Hsu, CC
   Chen, CPC
   Chow, SE
   Wang, JS
   Shyu, YC
   Lu, MJ
AF Huang, Ching-Hui
   Hsu, Chih-Chin
   Chen, Carl Pai-Chu
   Chow, Shu-Er
   Wang, Jong-Shyan
   Shyu, Yu-Chiau
   Lu, Mu-Jie
TI Negative pressure induces p120-catenin-dependent adherens junction
   disassembly in keratinocytes during wound healing
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Cell movement;
   E-cadherin
ID COLLECTIVE CELL-MIGRATION; E-CADHERIN; P120 CATENIN; BETA-CATENIN;
   TYROSINE PHOSPHORYLATION; TIGHT JUNCTIONS; FIBRIN MATRIX; THERAPY;
   MECHANISMS; PROLIFERATION
AB A negative-pressure of 125 mm Hg (NP) has been widely used to treat chronic wounds in modern medicine. Keratinocytes under NP treatment have shown accelerated cell movement and decreased E-cadherin expression. However, the molecular mechanism of E-cadherin regulation under NP remains incompletely understood. Therefore, we investigated the E-cadherin regulation in keratinocytes (HaCaT cells) under NP. HaCaT cells were treated at ambient pressure (AP) and NP for 12 h. Cell movement was measured by traditional and electric wound healing assays at the 2 different pressures. Mutants with overexpression of p120-catenin (p120(ctn)) were used to observe the effect of NP on p120(ctn) and E-cadherin expression during wound healing. Cell fractionation and immunoblotting data showed that NP increased Y228-phosphorylated p120(ctn) level and resulted in the translocation of p120(ctn) from the plasma membrane to cytoplasm. Immunofluorescence images revealed that NP decreased the co-localization of p120(ctn) and E-cadherin on the plasma membrane. Knockdown of p120(ctn) reduced E-cadherin expression and accelerated cell movement under AP. Overexpression of the Y228-phosphorylation-mimic p120(ctn) decreased E-cadherin membrane expression under both AP and NP. Phosphorylation-deficient mutants conferred restored adherens junctions (AJs) under NP. The Src inhibitor blocked the phosphorylation of p120(ctn) and impeded cell migration under NP. In conclusion, Src-dependent phosphorylation of p120(ctn) can respond rapidly to NP and contribute to E-cadherin downregulation. The NP-induced disassembly of the AJ further accelerates wound healing. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Huang, Ching-Hui; Wang, Jong-Shyan] Chang Gung Univ, Grad Inst Rehabil Sci, Hlth Aging Res Ctr, Taoyuan, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung, Taiwan.
   [Hsu, Chih-Chin] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Chen, Carl Pai-Chu] Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Chow, Shu-Er] Chang Gung Univ, Ctr Gen Studies, Taoyuan, Taiwan.
   [Shyu, Yu-Chiau; Lu, Mu-Jie] Chang Gung Mem Hosp, Community Med Res Ctr, Keelung, Taiwan.
   [Shyu, Yu-Chiau] Acad Sinica, Inst Mol Biol, Taipei, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Academia Sinica - Taiwan
RP Hsu, CC (通讯作者)，Chang Gung Mem Hosp, Dept Phys Med & Rehabil, Keelung, Taiwan.
EM steele0618@gmail.com
OI Lu, Mu-Jie/0000-0002-2174-1153; Wang, Jong-Shyan/0000-0002-3095-9357;
   Shyu, Yu-Chiau/0000-0003-1747-2226
FU Chang Gung Medical Research Program [CMRPG2E0141, CMRPG2D0031]; Ministry
   of Science and Technology in Taiwan [MOST 103-2314-B-182-003]
FX The study was funded by the Chang Gung Medical Research Program
   (CMRPG2E0141 and CMRPG2D0031) and the Ministry of Science and Technology
   in Taiwan (MOST 103-2314-B-182-003). We thank Mr. Hsiao-Tung Liu in the
   Laser Scanning Confocal Microscopy Room, Chang Gung Memorial Hospital,
   Keelung, for providing excellent fluorescent images. Dr. Chih-Yi Chien
   in Community Medicine Research Center, Chang Gung Memorial Hospital,
   Keelung, and Dr. Yu-Shien Lee in Department of Biotechnology, Ming Chuan
   University and Genomic Medicine Research Core Laboratory, Chang Gung
   Memorial Hospital, Linkou, Toyuan, contribute greatly to microarray data
   analysis.
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NR 32
TC 6
Z9 9
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 0006-3002
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD SEP
PY 2016
VL 1863
IS 9
BP 2212
EP 2220
DI 10.1016/j.bbamcr.2016.05.017
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DS2LI
UT WOS:000380600600007
PM 27220534
DA 2026-07-24
ER

PT J
AU Curchod, P
   Clerc, D
   Jurt, J
   Hubner, M
   Hahnloser, D
   Demartines, N
   Grass, F
AF Curchod, P.
   Clerc, D.
   Jurt, J.
   Hubner, M.
   Hahnloser, D.
   Demartines, N.
   Grass, F.
TI Closed-wound negative pressure therapy dressing after loop ostomy
   closure: a retrospective comparative study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PRIMARY SKIN CLOSURE; STOMA REVERSAL; INFECTIONS
AB Closed-wound negative pressure wound therapy (NPWT) dressings were recently introduced with the purpose to reduce incisional surgical site infections (iSSI) in high-risk wounds. The aim of this study was to compare iSSI rates in patients after ostomy closure with and without additional application of a closed-wound NPWT dressing. Single-center retrospective analysis of consecutive patients undergoing ileo- or colostomy closure over an 8-year period (January 2013-January 2021). Intradermal non-purse string technique with absorbable sutures were used in all patients. Since November 2018, all patients (study group) received a NPWT device for a maximum of 5 days postoperatively (PICO, SMITH AND NEPHEW). Primary outcome was iSSI rate within 30 days of surgery. SSI was defined in accordance with the Center of Disease Control (CDC) classification and included superficial and deep incisional SSI. Data was retrieved from the institutional enhanced recovery after surgery (ERAS) database, with standardized complication assessment by trained abstractors. In total, 85 patients (25%) in the study group were comparable with 252 (75%) patients in the control group regarding demographics (age, gender, body mass index, ASA score), ostomy type and anastomotic technique (all p > 0.05), but not wound contamination class (class III: 5% vs 0%, p < 0.001). Median time to NPWT removal was 4 (IQR 3-5) days. Incisional SSI were observed in 4 patients (4.7%) in the study group and in 27 patients (10.7%) in the control group (p = 0.097). These preliminary results suggest a potential benefit of systematic application of the NPWT device after loop ostomy closure. A randomized controlled study is needed.
C1 [Curchod, P.; Clerc, D.; Jurt, J.; Hubner, M.; Hahnloser, D.; Demartines, N.; Grass, F.] Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, 26 Rue Bugnon, CH-1010 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Hubner, M (通讯作者)，Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Visceral Surg, 26 Rue Bugnon, CH-1010 Lausanne, Switzerland.
EM hubner@chuv.ch
RI Clerc, Daniel/HMP-2088-2023; hübner, martin/J-6715-2017; Hahnloser,
   Dieter/J-6714-2017
OI Clerc, Daniel/0000-0002-9285-3312; hübner, martin/0000-0002-4521-8279; 
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NR 16
TC 7
Z9 7
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 12
PY 2022
VL 12
IS 1
AR 7790
DI 10.1038/s41598-022-11856-8
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1F4TU
UT WOS:000795163100062
PM 35550575
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Victor, P
   Sarada, D
   Ramkumar, KM
AF Victor, Paul
   Sarada, Dronamraju
   Ramkumar, Kunka Mohanram
TI Pharmacological activation of Nrf2 promotes wound healing
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Chronic wounds; Nrf2 activators; Wound healing; Redox signaling
ID OXIDATIVE STRESS; DIABETIC FOOT; ANTIOXIDANT RESPONSE; MANUKA HONEY; BEE
   VENOM; (-)-EPIGALLOCATECHIN GALLATE; INFLAMMATORY MEDIATORS;
   TRANSCRIPTION FACTOR; ENDOTHELIAL-CELLS; DIMETHYL FUMARATE
AB Wound repair and regeneration is a complex orchestrated process, comprising several phases interconnecting various cellular events and triggering multiple intracellular molecular pathways in damaged cells and tissues. In several metabolic disorders including diabetes mellitus, delay in wound healing due to elevated levels of cellular stress poses a key challenge. Several therapeutic wound dressing materials and strategies including hyperbaric oxygen therapy and negative pressure wound therapy have been developed to accelerate repair and restore cellular homeostasis at the wound site. Further, tremendous progress has been made in identification of transcriptional regulators involved in the process of wound healing. Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox sensitive transcription factor, is the key regulator of intracellular redox homeostasis which induces the expression of cytoprotective genes and increases the production of antioxidants that scavenge free radicals. Activators of Nrf2 have been reported to combat oxidative stress and enhance the process of wound healing in several pathophysiological conditions, including diabetes and its complications such as diabetic foot ulcer, and chronic kidney disease, and diabetic nephropathy. Several bioactive compounds have been reported to reduce cellular stress, and thus accelerate cell proliferation, neovascularization results in repairing damaged tissues by the activation of the transcription factor, Nrf2. This review is focused on the strategies for diabetic wound healing and the highlights the role of bioactive compounds that activate the Nrf2 signaling and revitalize the cellular and molecular mechanism in the chronic wound niche, regulate and restore redox homeostasis thereby promoting wound repair and regeneration.
C1 [Victor, Paul; Sarada, Dronamraju; Ramkumar, Kunka Mohanram] SRM Inst Sci & Technol, Sch Bioengn, Dept Biotechnol, Chennai 603203, Tamil Nadu, India.
   [Ramkumar, Kunka Mohanram] SRM Inst Sci & Technol, SRM Res Inst, Life Sci Div, Chennai 603203, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai; SRM Institute of Science
   & Technology Chennai
RP Ramkumar, KM (通讯作者)，SRM Inst Sci & Technol, SRM Res Inst, Life Sci Div, Chennai 603203, Tamil Nadu, India.
EM ramkumarbiotech@gmail.com
RI ; Kunka Mohanram, Ramkumar/ADS-7217-2022
OI Dronamraju, Sarada/0000-0002-8883-0337; Santiago Raj, Paul
   Victor/0000-0001-6376-5930; Kunka Mohanram, Ramkumar/0000-0001-5450-902X
FU Indian Council of Medical Research [2020-9621]; Government of India; SRM
   Institute of Science and Technology, Kattankulathur, Chennai, India
FX The authors gratefully acknowledge the Indian Council of Medical
   Research (grant no. 2020-9621), Government of India for financial
   assistance. This work was, in part, supported by the SRM Institute of
   Science and Technology, Kattankulathur, Chennai, India.
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NR 141
TC 73
Z9 78
U1 1
U2 56
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 5
PY 2020
VL 886
AR 173395
DI 10.1016/j.ejphar.2020.173395
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OE6JJ
UT WOS:000580634600004
PM 32710954
DA 2026-07-24
ER

PT J
AU Curran, T
   Alvarez, D
   Del Valle, JP
   Cataldo, TE
   Poylin, V
   Nagle, D
AF Curran, T.
   Alvarez, D.
   Del Valle, J. Pastrana
   Cataldo, T. E.
   Poylin, V.
   Nagle, D.
TI Prophylactic closed-incision negative-pressure wound therapy is
   associated with decreased surgical site infection in high-risk
   colorectal surgery laparotomy wounds
SO COLORECTAL DISEASE
LA English
DT Article
DE Closed incision negative pressure therapy; surgical site infection;
   quality improvement
ID COST-MINIMIZATION ANALYSIS; AMERICAN-COLLEGE; READMISSION; STATISTICS;
   PREVENTION; TRIAL
AB Aim Surgical site infection in colorectal surgery is associated with significant healthcare costs, which may be reduced by using a closed-incision negative-pressure therapy device. The aim of this study was to assess the impact of closed-incision negative-pressure therapy on the incidence of surgical site infection. Method In this retrospective cohort study we evaluated all patients who had undergone high-risk open colorectal surgery at a single tertiary care centre from 2012 to 2016. We compared the incidence of surgical site infection between those receiving standard postoperative wound care between 2012 and 2014 and those receiving closed-incision negative-pressure therapy via a customizable device (Prevena Incision Management System, KCI, an Acelity company, San Antonio, Texas, USA) between 2014 and 2016. A validated surgical site infection risk score was used to create a 1:1 matched cohort subset. Results Negative pressure therapy was used in 77 patients and compared with 238 controls. Negative pressure patients were more likely to have a stoma (92% vs 48%, P < 0.01) and to be smokers (33% vs 15%, P < 0.01). Surgical site infection was higher in control patients (15%, n = 35/238) compared with negative pressure patients (7%, n = 5/77) (P = 0.05). On regression analysis, negative pressure therapy was associated with decreased surgical site infection (OR 0.27; 95% CI 0.09-0.78). These differences persisted in the matched analysis. Conclusion Negative pressure therapy was associated with decreased surgical site infection. Negative pressure therapy offers significant potential for quality improvement.
C1 [Curran, T.; Alvarez, D.; Del Valle, J. Pastrana; Cataldo, T. E.; Poylin, V.; Nagle, D.] Beth Israel Deaconess Med Ctr, Dept Surg, Div Colon & Rectal Surg, 330 Brookline Ave, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Curran, T (通讯作者)，30 Courtenay Dr,Suite 249 MSC 295, Charleston, SC 29425 USA.
EM thomascurran27@gmail.com
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NR 36
TC 34
Z9 43
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2019
VL 21
IS 1
BP 110
EP 118
DI 10.1111/codi.14350
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HG1EP
UT WOS:000454693600016
PM 30047611
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Beckmann, JH
   Aselmann, H
   Egberts, JH
   Bernsmeier, A
   Laudes, M
   Becker, T
   Schafmayer, C
   Ahrens, M
AF Beckmann, J. H.
   Aselmann, H.
   Egberts, J. H.
   Bernsmeier, A.
   Laudes, M.
   Becker, T.
   Schafmayer, C.
   Ahrens, M.
TI Robot-assisted vs laparoscopic gastric bypass. First experiences with
   the DaVinci system in bariatric surgery
SO CHIRURG
LA German
DT Article
DE Robot assisted surgery; DaVinci; Roux-en-Y gastric bypass; Obesity
   surgery; Postoperative complications
ID PERIOPERATIVE OUTCOMES; METAANALYSIS; OBESITY; COMPLICATIONS; RESECTION
AB Conventional laparoscopy is the gold standard in bariatric surgery. Internationally, robot-assisted surgery is gaining in importance. Up to now there are only few reports from Germany on the use of the system in bariatric surgery. Since January 2017 we have been performing robot-assisted gastric bypass surgery. It remains unclear whether the use of the robotic system has advantages over the well-established laparoscopic technique. Within a period from January to early August 2017 a total of 53 gastric bypass operations were performed. Of these 16 proximal redo Roux-en-Y gastric bypass operations were performed with the DaVinci Si system versus 29 laparoscopic procedures. A retrospective analysis of the perioperative course was carried out. Body weight, body mass index (BMI), Edmonton obesity staging system (EOSS) and American Society of Anesthesiologists (ASA) classification did not show significant differences. There were also no significant differences in terms of estimated blood loss, intraoperative complications, duration of surgery, postoperative inflammatory parameters and weight loss. There was no mortality and no need for revisional surgery in either group. After laparoscopic surgery there was a delayed occurrence of a leak of the gastrojejunostomy followed by readmission and endoscopic negative pressure wound therapy. The results show that the proximal Roux-en-Y gastric bypass can be performed safely and efficiently using the DaVinci surgical system. Significant differences to the conventional laparoscopic procedure were not found. Larger randomized controlled trials are needed to define the role of the DaVinci system in bariatric surgery.
C1 [Beckmann, J. H.; Aselmann, H.; Egberts, J. H.; Bernsmeier, A.; Becker, T.; Schafmayer, C.; Ahrens, M.] Univ Klinikum Schleswig Holstein, Klin Allgemeine Viszeral Transplantat Thorax & Ki, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany.
   [Laudes, M.] Univ Klinikum Schleswig Holstein, Klin Innere Med 1, Campus Kiel, Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Beckmann, JH (通讯作者)，Univ Klinikum Schleswig Holstein, Klin Allgemeine Viszeral Transplantat Thorax & Ki, Campus Kiel,Arnold Heller Str 3, D-24105 Kiel, Germany.
EM jan.beckmann@uksh.de
RI Beckmann, Jan/AAG-3099-2021; Laudes, Matthias/C-8885-2011; Egberts,
   Jan-Hendrik/E-3211-2015
OI Beckmann, Jan/0000-0002-8069-6786; 
CR Ahmad A, 2016, SURG ENDOSC, V30, P3792, DOI 10.1007/s00464-015-4675-y
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NR 19
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0009-4722
EI 1433-0385
J9 CHIRURG
JI Chirurg
PD AUG
PY 2018
VL 89
IS 8
BP 612
EP 620
DI 10.1007/s00104-018-0629-y
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GP7QX
UT WOS:000441100600007
PM 29589076
DA 2026-07-24
ER

PT J
AU Gillespie, BM
   Rickard, CM
   Thalib, L
   Kang, E
   Finigan, T
   Homer, A
   Lonie, G
   Pitchford, D
   Chaboyer, W
AF Gillespie, Brigid M.
   Rickard, Claire M.
   Thalib, Lukman
   Kang, Evelyn
   Finigan, Tracey
   Homer, Allison
   Lonie, Gordon
   Pitchford, Don
   Chaboyer, Wendy
TI Use of Negative-Pressure Wound Dressings to Prevent Surgical Site
   Complications After Primary Hip Arthroplasty: A Pilot RCT
SO SURGICAL INNOVATION
LA English
DT Article
DE hip replacement; orthopedic; infection; vacuum dressing; feasibility;
   complications
ID THERAPY; INFECTION
AB Purpose. Negative-pressure wound therapy (NPWT) is increasingly used for primary surgical incisions despite the paucity of evidence. Study objectives were to assess the use of NPWT on surgical sites to prevent infections and other wound complications after elective primary hip arthroplasty and to consider feasibility of a larger trial. Methods. A nonmasked, randomized controlled pilot trial. Patients were recruited preoperatively from the preadmission clinic of an Australian hospital during 2013-2014. Computer-generated randomization was performed with allocation concealed until completion of surgery. The intervention group received NPWT (PICO) while the control group received the standard care hydrocolloid, reinforced with 2 absorbent dressings. Patients were followed for 6 weeks for postoperative complications (infection, length of stay, readmission) and skin complications (bruising, seroma, hematoma, dehiscence). Feasibility end points included numbers recruited, randomized, and followed up; fidelity; and costs. Results. Of 77 people approached, 76 were recruited, and 70 were randomized. Of 35 in the negative-pressure group, 2 received the standard dressing. Attrition at 6 weeks exceeded 10% in both groups. Dressing costs were lower in the control group ($3.01/d vs $38.40/d); SSI incidence was 2/35 in the NPWT and 3/35 in the control group (intention to treat: risk ratio [RR] = 0.67; 95% confidence interval [CI] = 0.12-3.7; P = .65). NPWT patients experienced more postoperative wound complications (RR = 1.6; 95% CI = 1.0-2.5; P = .04). Conclusion. A reduction of 3% in SSI incidence suggests that a definitive trial requires approximately 900 patients per group. Yet there is uncertainty around the benefit of NPWT after elective hip arthroplasty.
C1 [Gillespie, Brigid M.; Rickard, Claire M.; Kang, Evelyn; Chaboyer, Wendy] Griffith Univ, Gold Coast, Qld 4222, Australia.
   [Thalib, Lukman] Kuwait Univ, Safat, Kuwait.
   [Finigan, Tracey; Homer, Allison; Lonie, Gordon; Pitchford, Don] Gold Coast Univ Hosp, Southport, Qld, Australia.
C3 Griffith University; Kuwait University; Gold Coast University Hospital
RP Gillespie, BM (通讯作者)，Griffith Univ, NHMRC Res Ctr Clin Excellence Nursing Intervent N, Gold Coast, Qld 4222, Australia.
EM b.gillespie@griffith.edu.au
RI Gillespie, Brigid/E-7799-2012; Thalib, Lukman/HAI-7553-2022; Rickard,
   Claire/C-3440-2008; Chaboyer, Wendy/F-9588-2018
OI Gillespie, Brigid/0000-0003-3186-5691; Thalib,
   Lukman/0000-0002-1211-6495; Rickard, Claire/0000-0002-6341-7415;
   Chaboyer, Wendy/0000-0001-9528-7814; Kang, Evelyn/0000-0001-8253-1638
FU Queensland Government Department of Employment, Economic Development &
   Innovation Smart Futures Research Fellowship; Office for Medical &
   Health Research, Queensland Government; National Health & Medical
   Research Council Centre
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: BG
   gratefully acknowledges the financial support of The Queensland
   Government Department of Employment, Economic Development & Innovation
   Smart Futures Research Fellowship and the Office for Medical & Health
   Research, Queensland Government; BG, CR, EK and WC also acknowledge the
   support of National Health & Medical Research Council Centre for
   Research Excellence in Nursing Interventions for Hospitalised Patients
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NR 23
TC 62
Z9 66
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD OCT
PY 2015
VL 22
IS 5
BP 488
EP 495
DI 10.1177/1553350615573583
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CS0RE
UT WOS:000361769100007
PM 25733548
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ruiz-Tovar, J
   Boermeester, MA
   Bordeianou, L
   Chang, GJ
   Gorgun, E
   Justinger, C
   Lawson, EH
   Leaper, DJ
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   Wick, EC
   Hedrick, TL
AF Ruiz-Tovar, Jaime
   Boermeester, Marja A.
   Bordeianou, Liliana
   Chang, George J.
   Gorgun, Emre
   Justinger, Christoph
   Lawson, Elise H.
   Leaper, David J.
   Mahmoud, Najjia N.
   Mantyh, Christopher
   McGee, Michael F.
   Nfonsam, Valentine
   Rubio-Perez, Ines
   Wick, Elizabeth C.
   Hedrick, Traci L.
CA Colorectal Delphi Facilitating Grp
TI Delphi Consensus on Intraoperative Technical/Surgical Aspects to Prevent
   Surgical Site Infection after Colorectal Surgery
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article; Proceedings Paper
CT 107th Annual Clinical Congress and Scientific Forum of the
   American-College-of-Surgeons (ACS) / Owen H. Wangensteen Scientific
   Forum
CY OCT 23-28, 2021
CL ELECTR NETWORK
SP Amer Coll Surg
ID RANDOMIZED CONTROLLED-TRIAL; TRICLOSAN-COATED SUTURES; WOUND EDGE
   PROTECTOR; SKIN CLOSURE; ABDOMINAL-SURGERY; SUBCUTICULAR SUTURES;
   GASTROINTESTINAL SURGERY; CLINICAL-TRIAL; OPEN-LABEL; METAANALYSIS
AB BACKGROUND: Previous studies have focused on the development and evaluation of care bundles to reduce the risk of surgical site infection (SSI) throughout the perioperative period. A focused examination of the technical/surgical aspects of SSI reduction during CRS has not been conducted. This study aimed to develop an expert consensus on intraoperative technical/surgical aspects of SSI prevention by the surgical team during colorectal surgery (CRS).
   STUDY DESIGN: In a modified Delphi process, a panel of 15 colorectal surgeons developed a consensus on intraoperative technical/surgical aspects of SSI prevention undertaken by surgical personnel during CRS using information from a targeted literature review and expert opinion. Consensus was developed with up to three rounds per topic, with a prespecified threshold of >= 70% agreement.
   RESULTS: In 3 Delphi rounds, the 15 panelists achieved consensus on 16 evidence-based statements. The consensus panel supported the use of wound protectors/retractors, sterile incision closure tray, preclosure glove change, and antimicrobial sutures in reducing SSI along with wound irrigation with aqueous iodine and closed-incision negative pressure wound therapy in high-risk, contaminated wounds.
   CONCLUSIONS: Using a modified Delphi method, consensus has been achieved on a tailored set of recommendations on technical/surgical aspects that should be considered by surgical personnel during CRS to reduce the risk of SSI, particularly in areas where the evidence base is controversial or lacking. This document forms the basis for ongoing evidence for the topics discussed in this article or new topics based on newly emerging technologies in CRS. (C) 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons.
C1 [Ruiz-Tovar, Jaime] Univ Rey Juan Carlos, Dept Surg, Madrid, Spain.
   [Boermeester, Marja A.] Free Univ Amsterdam Hosp, Dept Surg, Amsterdam, Netherlands.
   [Bordeianou, Liliana] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
   [Chang, George J.] Univ Texas MD Anderson Canc Ctr, Dept Colon & Rectal Surg, Houston, TX 77030 USA.
   [Gorgun, Emre] Cleveland Clin, Digest Dis & Surg Inst, Dept Colorectal Surg, Cleveland, OH USA.
   [Justinger, Christoph] Klinikum Karlsruhe, Dept Gen & Visceral Surg, Karlsruhe, Germany.
   [Justinger, Christoph] Albert Ludwigs Univ Freiburg, Freiburg, Germany.
   [Lawson, Elise H.] Univ Wisconsin, Dept Surg, Div Colorectal, Madison, WI USA.
   [Leaper, David J.] Univ Newcastle, Surg, Newcastle Upon Tyne, Tyne & Wear, England.
   [Mahmoud, Najjia N.] Univ Penn, Div Colon & Rectal Surg, Philadelphia, PA 19104 USA.
   [Mantyh, Christopher] Duke Univ, Med Ctr, Dept Surg, Durham, NC USA.
   [McGee, Michael F.] Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL USA.
   [Nfonsam, Valentine] Univ Arizona, Dept Surg, Tucson, AZ USA.
   [Rubio-Perez, Ines] La Paz Univ Hosp, Dept Gen Surg, Colorectal Surg Unit, Madrid, Spain.
   [Wick, Elizabeth C.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
   [Hedrick, Traci L.] Univ Virginia Hlth Syst, Dept Surg, 1215 Lee St, Charlottesville, VA 22903 USA.
C3 Universidad Rey Juan Carlos; Vrije Universiteit Amsterdam; Amsterdam
   University Medical Center; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; University of Texas
   System; UTMD Anderson Cancer Center; Cleveland Clinic Foundation;
   Municipal Hospital Karlsruhe; University of Freiburg; University of
   Wisconsin System; University of Wisconsin Madison; Newcastle University
   - UK; University of Pennsylvania; Duke University; Northwestern
   University; Feinberg School of Medicine; University of Arizona; Hospital
   Universitario La Paz; University of California System; University of
   California San Francisco; University of Virginia; University of Virginia
   (UVA) Health System
RP Hedrick, TL (通讯作者)，Univ Virginia Hlth Syst, Dept Surg, 1215 Lee St, Charlottesville, VA 22903 USA.
EM th8q@hscmail.mcc.virginia.edu
RI mantyh, christopher/AAJ-9140-2021; Lawson, Elise/PYZ-3977-2026; Hedrick,
   Traci/AAG-9788-2019
OI Rubio-Perez, Ines/0000-0002-3960-6865; McGee,
   Michael/0000-0002-9498-4252
FU Johnson Johnson; Ethicon, Inc.
FX This study was supported by funding from Johnson & Johnson and Ethicon,
   Inc.
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NR 66
TC 28
Z9 31
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD JAN
PY 2022
VL 234
IS 1
BP 1
EP 11
DI 10.1097/XCS.0000000000000022
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA ZO7MS
UT WOS:000765911900001
PM 35213454
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Nguyen, T
   Rodriguez-Collazo, ER
AF Tea Nguyen
   Rodriguez-Collazo, Edgardo R.
TI Healing Heel Ulcers in High-Risk Patients: Distally Based Peroneus
   Brevis Muscle Flap Case Series
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE amputation prevention; calcaneus; limb salvage; orthoplastic; wound care
ID SOFT-TISSUE DEFECTS; LOWER LEG; FOOT; RECONSTRUCTION; COMPLICATIONS;
   ANKLE
AB The purpose of this study was to demonstrate use of a distally based peroneus brevis muscle flap in high-risk patients with diabetes and peripheral vascular disease for limb salvage of nonhealing heel ulcerations. Seventeen patients were referred for a below-knee amputation because of nonhealing heel ulcerations and peripheral vascular disease. As a last resort, 17 distally based peroneus brevis muscle flaps were elevated in 17 patients with full-thickness heel ulcerations measuring an average defect size of 14.11 cm2. All flaps were supplemented with concentrated bone marrow aspirate, negative pressure wound therapy, bilayer wound matrix, and static external fixation for an average time of 10.3 weeks. Split-thickness skin graft was delayed by an average of 17.5 days. All procedures were performed on patients diagnosed with diabetes, advanced peripheral arterial disease and a nonhealing heel ulcer present >1 year. All flaps survived at 1.5 years follow-up. The average time to healing was 10.3 weeks. No major amputations were performed to date. Partial tip necrosis occurred in 2 patients and healed uneventfully with local wound care. Distally based peroneus brevis muscle flaps in patients with diabetes and peripheral vascular disease offer a reliable alternative to limb salvage for full-thickness heel ulcerations measuring up to 7 x 6 cm. Combinatorial procedures are necessary to improve outcomes in high-risk patients whose alternative is a major amputation. Published by Elsevier Inc. on behalf of the American College of Foot and Ankle Surgeons.
C1 [Tea Nguyen] Watsonville Community Hosp, Dept Surg, Watsonville, CA USA.
   [Rodriguez-Collazo, Edgardo R.] Presence St Joseph Hosp, Dept Surg, Chicago, IL USA.
RP Nguyen, T (通讯作者)，9029 Soquel Ave,Suite D, Santa Cruz, CA 95062 USA.
EM teadpm@gmail.com
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NR 33
TC 12
Z9 13
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAR
PY 2019
VL 58
IS 2
BP 341
EP 346
DI 10.1053/j.jfas.2018.07.010
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA HN5JF
UT WOS:000460219700027
PM 30583837
DA 2026-07-24
ER

PT J
AU Shih, YJ
   Chang, SC
   Wang, CH
   Dai, NT
   Chen, SG
   Chen, TM
   Tzeng, YS
AF Shih, Yu-Jen
   Chang, Shun-Cheng
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chen, Shyi-Gen
   Chen, Tim-Mo
   Tzeng, Yuan-Sheng
TI A Simple Protocol for the Management of Deep Sternal Surgical Site
   Infection: A Retrospective Study of Twenty-Five Cases
SO SURGICAL INFECTIONS
LA English
DT Article
ID OPEN-HEART-SURGERY; MEDIASTINITIS; FLAP
AB Background: Deep sternal incisional surgical site infection is a serious and potentially life-threatening complication after open heart surgery. Although a rare post-operative complication, the rates of post-operative morbidity and mortality are greater in patients who develop a deep sternal incisional surgical site infection than in those who do not.
   Methods: We evaluated retrospectively the results of patients who developed a deep sternal incisional surgical site infection who were treated with either a pectoralis major flap or delayed primary closure after previous negative-pressure wound therapy (NWPT). From July 2007 to July 2012, 25 patients had a deep sternal incisional surgical site infection after open heart surgery in the Departments of Plastic Surgery and Cardiac Surgery of the Tri-Service General Hospital Medical Center. Sternal refixation was not performed in our patients.
   Results: In 15 patients, a unilateral or bilateral pectoralis major advancement flap with a myocutaneous or muscle flap was used. In seven patients, delayed primary closure was performed after NPWT. One patient received a rectus abdominis myocutaneous flap and another received a free anterior lateral thigh flap. One patient died after developing nosocomial pneumonia with severe sepsis after debridement.
   Conclusions: In our series, no patient required sternal re-fixation. Our findings suggest that delayed primary closure and use of a unilateral or bilateral pectoralis major flap following NPWT for a deep sternal incisional surgical site infection are simple and quick methods for managing such difficult surgical incisions even if the deep sternal surgical site infection is located in the lower one-third of the sternum.
C1 [Shih, Yu-Jen; Chang, Shun-Cheng; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Chen, Tim-Mo; Tzeng, Yuan-Sheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University
RP Tzeng, YS (通讯作者)，Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, 325 Cheng Kung Rd Sec 2, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI Tzeng, Yuan-sheng/AAD-8843-2020; Shih, Yu-Jen/JAC-4777-2023; Chen,
   Tim/KVV-8381-2024
CR [Anonymous], J MED SCI
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NR 20
TC 3
Z9 3
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC 1
PY 2014
VL 15
IS 6
BP 815
EP 820
DI 10.1089/sur.2013.245
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AW5TA
UT WOS:000346335500024
PM 25493910
DA 2026-07-24
ER

PT J
AU Astasio-Picado, A
   Jurado-Palomo, J
   Pozo-Aranda, B
   Cobos-Moreno, P
AF Astasio-Picado, Alvaro
   Jurado-Palomo, Jesus
   Pozo-Aranda, Belen
   Cobos-Moreno, Paula
TI Comparative Evidence on Negative Pressure Therapy and Hyperbaric Oxygen
   Therapy for Diabetic Foot Ulcers: A Systematic Review of Independent
   Effectiveness and Clinical Applicability
SO MEDICINA-LITHUANIA
LA English
DT Review
DE diabetic foot ulcer; negative pressure therapy; hyperbaric oxygen
   therapy; wound healing; amputation prevention
ID WOUND THERAPY; METAANALYSIS
AB Background and Objectives: To evaluate and synthesize evidence on the independent clinical effectiveness, safety, and applicability of Negative Pressure Wound Therapy (NPWT) and Hyperbaric Oxygen Therapy (HBOT) in diabetic foot ulcers (DFUs), and to determine whether current evidence allows for a direct comparison between both interventions: NPWT and HBOT are widely advanced therapies for DFUs. Although both show benefits, the relative superiority of one over the other remains unclear. Systematic review of the literature conducted in accordance with PRISMA guidelines. Materials and Methods: A comprehensive literature search was performed using two electronic databases. The review included randomized controlled trials, systematic reviews, meta-analyses, and non-randomized studies. Methodological quality and risk of bias were assessed using validated tools: RoB 2.0 for randomized trials, AMSTAR-2 for systematic reviews, and ROBINS-I for non-randomized studies. Results: A total of 22 studies were included. NPT was shown to be effective in accelerating wound healing, though results varied depending on the type of intervention and clinical context. HBOT demonstrated beneficial effects on angiogenesis and significantly reduced the rate of major amputations. Both therapies presented significant advantages in the management of diabetic foot ulcers. Conclusions: Negative pressure therapy and hyperbaric oxygen therapy are both effective treatments for diabetic foot ulcer healing. However, treatment selection should be individualized based on patient-specific clinical factors, ulcer severity, and available healthcare resources. Integrating these advanced therapies within a multidisciplinary care approach may optimize outcomes and reduce the risk of complications. Future research should include standardized, head-to-head RCTs.
C1 [Astasio-Picado, Alvaro; Jurado-Palomo, Jesus; Pozo-Aranda, Belen] Univ Castilla La Mancha, Fac Hlth Sci, Physiotherapy Nursing & Physiol Dept, Toledo 45600, Spain.
   [Astasio-Picado, Alvaro; Cobos-Moreno, Paula] Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Caceres 10600, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Extremadura
RP Astasio-Picado, A (通讯作者)，Univ Castilla La Mancha, Fac Hlth Sci, Physiotherapy Nursing & Physiol Dept, Toledo 45600, Spain.; Astasio-Picado, A (通讯作者)，Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Caceres 10600, Spain.
EM alvaro.astasio@uclm.es
RI Astasio-Picado, Alvaro/Y-3530-2019; cobos moreno, paula/HKF-0874-2023;
   Jurado-Palomo, Jesús/PJT-1779-2026
OI Astasio-Picado, Alvaro/0000-0001-9915-0567; 
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NR 50
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JAN 4
PY 2026
VL 62
IS 1
AR 109
DI 10.3390/medicina62010109
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO8EN
UT WOS:001670873500001
PM 41597395
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, L
   Gao, SF
   Jiang, YS
   Chen, P
   Gong, ZH
AF Wang, Lu
   Gao, Sheng-Feng
   Jiang, Ya-Su
   Chen, Peng
   Gong, Zhen-Hua
TI Study on the effect of negative pressure occlusion drainage combined
   with silver ion dressing on inflammatory factors (IL-6, TNF-α) and
   healing effect of diabetic foot ulcer
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetic foot; negative pressure closed drainage; silver ion dressings;
   inflammatory factors; ulcers
ID IMPACT
AB Background: Diabetic foot ulcers impair quality of life and prognosis in diabetes. IL-6 and TNF-alpha regulate wound healing through inflammation. Although negative pressure wound therapy and silver dressings aid chronic wound repair, their combined efficacy in DFUs remains understudied. Objective: This study aimed to assess how negative pressure occlusion drainage combined with silver ion dressing affects inflammatory cytokine levels (IL-6, TNF-alpha) and wound healing in patients with diabetic foot ulcer. Methods: This study included 78 DFU patients treated with NPWT plus silver dressings (February 2023-April 2025). Serum IL-6 and TNF-alpha levels were measured at baseline, day 14, and day 30 post-treatment. Results: The findings indicated that IL-6 and TNF-alpha levels were significantly reduced at 14- and 30-days post-treatment compared to pre-treatment levels (P < 0.001), and the findings indicated a notable reduction in the wound area, with a healing duration of 19.49 +/- 4.18 days and granulation tissue appearing in 6.83 +/- 1.85 days. After 30 days of treatment, the healing rate reached 93.59%. The incidence of adverse reactions was low, 6.41%, and most of them were mild skin itching, nausea and vomiting, and a small amount of diarrhea. Conclusion: Negative pressure occlusion drainage combined with silver ion dressing has potential advantages in reducing inflammatory response and promoting the healing of diabetic foot ulcers, which is worthy of clinical application. In the future, multicenter randomized controlled trials are needed to further verify its efficacy and safety.
C1 [Wang, Lu; Gao, Sheng-Feng; Jiang, Ya-Su; Chen, Peng; Gong, Zhen-Hua] Nantong First Peoples Hosp, Dept Burn & Plast Surg & Wound Repair, Nantong, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Gong, ZH (通讯作者)，Nantong First Peoples Hosp, Dept Burn & Plast Surg & Wound Repair, Nantong, Jiangsu, Peoples R China.
EM wangluu1208@163.com
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NR 28
TC 0
Z9 0
U1 5
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 28
PY 2025
VL 16
AR 1689232
DI 10.3389/fendo.2025.1689232
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T5237
UT WOS:001637680300001
PM 41393293
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Tian, BX
   Yang, X
   Liu, Y
   Wei, CL
   Liu, DJ
   Ren, X
   Lin, HL
AF Tian, Baoxiang
   Yang, Xiong
   Liu, Yang
   Wei, Chunlin
   Liu, Dujuan
   Ren, Xue
   Lin, Hailong
TI The application effect of autologous platelet-rich plasma combined with
   negative pressure sealing drainage technology in pressure ulcer wound
   repair
SO MEDICINE
LA English
DT Article
DE autologous platelet-rich plasma; negative pressure sealed drainage;
   pressure sores; wound repair
ID THERAPY; INJURY
AB This study aimed to evaluate the efficacy of combining autologous platelet-rich plasma (PRP) with negative pressure wound therapy (NPWT) for the repair of pressure ulcers. We included 90 patients with pressure ulcers from General Technology Gemstone Flower Healthcare Jilin City Hospital of Chemical Industry between January 2021 and December 2023. Patients were randomly assigned to either a control group or an observation group, with 45 patients in each. The control group received NPWT alone, while the observation group received a combination of PRP and NPWT. Outcomes were compared between the groups, including clinical efficacy, wound recovery time (infection control time, wound healing time, hospital stay), levels of inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, white blood cell count), pain scores (numerical rating scale), Pressure Ulcer Scale for Healing scores, and incidence of complications. The observation group demonstrated a total effective rate of 95.56% (43/45), significantly higher than the control group's 80.00% (35/45) (P < .05). Additionally, the observation group had significantly shorter infection control times, wound healing times, and hospital stays (P < .05). Two weeks post-surgery, the observation group had significantly lower levels of C-reactive protein, erythrocyte sedimentation rate, and white blood cell count, as well as reduced numerical rating scale and Pressure Ulcer Scale for Healing scores (P < .05). The incidence of complications was 6.67% (3/45) in the observation group compared to 33.33% (15/45) in the control group, with a significant difference (P < .05). Combining autologous PRP with NPWT significantly improves clinical outcomes, reduces inflammatory responses, decreases pain, accelerates wound healing, and lowers complication rates in patients with pressure ulcers.
C1 [Tian, Baoxiang; Yang, Xiong; Liu, Yang; Wei, Chunlin; Liu, Dujuan; Ren, Xue; Lin, Hailong] Gen Technol Gemstone Flower Healthcare Jilin City, Dept Burns & Plast Surg, Jilin 132000, Peoples R China.
RP Lin, HL (通讯作者)，Gen Technol Gemstone Flower Healthcare Jilin City, Dept Burns & Plast Surg, Jilin 132000, Peoples R China.
EM Tianbaoxiang68@163.com; yangxiong19740503@sina.com; 573484069@qq.com;
   71671932@qq.com; 573484069@qq.com; 770534927@qq.com; 13019164447@163.com
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NR 25
TC 6
Z9 7
U1 3
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 1
PY 2024
VL 103
IS 44
AR e39672
DI 10.1097/MD.0000000000039672
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L2Z3R
UT WOS:001349448700031
PM 39496059
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU de Araujo, TAA
   Locatelli, FR
   da Silva-López, RE
   do Carmo, FA
AF de Araujo, Thayane Aparecida Alves
   Locatelli, Fernanda Resende
   da Silva-Lopez, Raquel Elisa
   do Carmo, Flavia Almada
TI Formulations with Active Plant Molecules and Additional Therapies in
   Wound Healing
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Review
DE Wound healing; Wound therapy; Plant extracts; Plant active molecules;
   Wound dressing; Nanoformulations
ID TOPICAL FORMULATION; ESSENTIAL OILS; ALOE-VERA; EXTRACT; PAPAIN;
   PHYTOTHERAPY; BROMELAIN; POLYSACCHARIDES; ANTIBACTERIAL; PROLIFERATION
AB Chronic wounds are important public health issues, affecting 1.51 to 2.21 per 1000 population. These hard-to-heal wounds affect the workers, due to pain, possibility of infection, amputation, and death, impacting around 2-4% of the health budget of countries. Since ancient times, humans have used plants to treat wounds. Intensive investigation of medicinal plants, their extracts, active molecules and respective formulations begin in the first half of the twentieth century. This review aims to present the definition of wounds and their healing mechanisms; the plants and their molecules with potential to heal wounds; the main developed and patented herbal formulations; additional therapies and future trends in this field. The scientific literature on the subject was investigated in the following databases: Pubmed, Science Direct, Scopus, Lilacs, and Scielo. The Derwent Innovations plataform was used for patent research. The study covered the description of wounds and the wound-healing process, medicinal plants employed in wound healing and active molecules, such as flavonoids, terpenes, polysaccharides, and proteases, along with many types of distinct formulations used to treat wounds, especially gels, creams, ointments and film membranes, and additional therapies that included skin substitutes and grafts, negative pressure wound therapy, and hyperbaric oxygen therapy. Great advancement has been observed over the main developed and patented herbal formulations based in the Green Chemistry principles. Classical formulations containing active plant molecules are commonly used to treat wounds. However, more sophisticated nanosystems and additional therapies enable important advances in the wound-healing.
C1 [de Araujo, Thayane Aparecida Alves; Locatelli, Fernanda Resende; do Carmo, Flavia Almada] Univ Fed Rio De Janeiro, Fac Farm, Dept Farmacos & Medicamentos, Rio De Janeiro, RJ, Brazil.
   [de Araujo, Thayane Aparecida Alves; da Silva-Lopez, Raquel Elisa] Fundacao Oswaldo Cruz, Dept Prod Nat, Grp Bioquim Proteases & Inibidores Proteases Orige, Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro; Fundacao Oswaldo Cruz
RP do Carmo, FA (通讯作者)，Univ Fed Rio De Janeiro, Fac Farm, Dept Farmacos & Medicamentos, Rio De Janeiro, RJ, Brazil.
EM facarmo@pharma.ufrj.br
RI ; Carmo, Flavia/AAP-3384-2020
OI Aparecida Alves de Araujo, Thayane/0000-0003-1951-4039; Resende
   Locatelli, Fernanda/0000-0001-5006-4748; Carmo,
   Flavia/0000-0003-0474-9070
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES)
FX This work was supported by Fundacao Carlos Chagas Filho de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ); Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES).
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NR 223
TC 0
Z9 0
U1 1
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD FEB
PY 2025
VL 35
IS 1
BP 1
EP 22
DI 10.1007/s43450-024-00593-w
EA SEP 2024
PG 22
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA U7C6R
UT WOS:001311966000002
DA 2026-07-24
ER

PT J
AU Chung, JNC
   Ali, O
   Hawthornthwaite, E
   Watkinson, T
   Blyth, U
   McKigney, N
   Harji, DP
   Griffiths, B
AF Chung, Jordan Ng Cheong
   Ali, Omar
   Hawthornthwaite, Emma
   Watkinson, Thomas
   Blyth, Ursula
   McKigney, Niamh
   Harji, Deena P.
   Griffiths, Ben
TI Closed incision negative pressure wound therapy is associated with
   reduced surgical site infection after emergency laparotomy: A propensity
   matched-cohort analysis
SO SURGERY
LA English
DT Article
ID ABDOMINAL-SURGERY; COMPLICATIONS; PREVENTION; MORBIDITY
AB Background: Surgical site infection contributes to a significant proportion of postoperative morbidity in patients undergoing emergency laparotomy. Surgical site infections cause significant patient burden, increase duration of stay, and have economic implications. Closed incision negative pressure therapy has been shown to reduce surgical site infection rates in patients undergoing elective laparotomy; however, there is limited evidence for their use in the emergency setting. This study aims to compare rates of surgical site infection between patients receiving closed incision negative pressure therapy and standard surgical dressing after emergency laparotomy through a propensity matched analysis. Methods: A registry-based, prospective cohort study was undertaken using data from the National Emergency Laparotomy Audit database at our center. The primary outcome measure was surgical site infection as defined by the Centers for Disease Control criteria. Secondary outcomes included 30-day postoperative morbidity and grade, duration of stay, 30-day mortality, and readmission rates. A propensity-score matching was performed in a 1:1 ratio to mitigate for selection bias. Results: A total of 1,484 patients were identified from the National Emergency Laparotomy Audit data set, and propensity-score matching resulted in 2 equally matched cohorts with 237 patients in each arm. The rate of surgical site infection was significantly lower in the closed incision negative pressure therapy cohort (16.9% vs 33.8%, P < .001). There were no overall differences in 30-day morbidity, Clavien-Dindo grade, Comprehensive Complication Index severity, length of hospital stay, reoperation rates, and 30-day mortality between the 2 groups. Conclusions: Prophylactic closed incision negative pressure therapy in emergency laparotomy patients is associated with a reduction in surgical site infection rates. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Chung, Jordan Ng Cheong; Ali, Omar] Newcastle Univ, Med Sch, Newcastle Upon Tyne, Tyne & Wear, England.
   [Hawthornthwaite, Emma; Watkinson, Thomas; Blyth, Ursula; McKigney, Niamh; Harji, Deena P.] Hlth Educ North East, Waterfront 4 Goldcrest Way, Newcastle Upon Tyne NE15 8NY, Tyne & Wear, England.
   [Griffiths, Ben] Royal Victoria Infirm, Dept Colorectal Surg, Newcastle Upon Tyne, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Harji, DP (通讯作者)，Hlth Educ North East, Waterfront 4 Goldcrest Way, Newcastle Upon Tyne NE15 8NY, Tyne & Wear, England.
EM deena.harji@nhs.nt
RI ; Harji, Deena/AAZ-2428-2020
OI Blyth, Ursula/0000-0001-6846-8687; Ali, Omar/0000-0003-3741-0815;
   Griffiths, Ben/0000-0002-8745-1861; McKigney, Niamh
   Aine/0000-0003-1599-5701; 
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NR 28
TC 15
Z9 15
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD NOV
PY 2021
VL 170
IS 5
BP 1568
EP 1573
DI 10.1016/j.surg.2021.04.009
EA OCT 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WM3NW
UT WOS:000710996400042
PM 34052025
DA 2026-07-24
ER

PT J
AU Tavares, G
   Tustumi, F
   Tristao, LS
   Bernardo, WM
AF Tavares, Guilherme
   Tustumi, Francisco
   Tristao, Luca Schiliro
   Bernardo, Wanderley Marques
TI Endoscopic vacuum therapy for anastomotic leak in esophagectomy and
   total gastrectomy: a systematic review and meta-analysis
SO DISEASES OF THE ESOPHAGUS
LA English
DT Review
DE negative pressure wound therapy; anastomotic leak; esophagectomy;
   gastrectomy; meta-analysis
ID ASSISTED CLOSURE; WOUND THERAPY; RESECTION; CANCER; PERFORATIONS;
   OUTCOMES; DEFECTS; 3-FIELD
AB The curative treatment for esophageal and gastric cancer is primarily surgical resection. One of the main complications related to esophagogastric surgery is the anastomotic leak. This complication is associated with a prolonged length of stay, reduced quality of life, high treatment costs, and an increased mortality rate. The placement of endoluminal stents is the most frequent endoscopic therapy in these cases. However, since its introduction, endoscopic vacuum therapy has been shown to be a promising alternative in the management of this complication. This study primarily aims to evaluate the efficacy and safety of endoscopic vacuum therapy for the treatment of anastomotic leak in esophagectomy and total gastrectomy. A systematic review and meta-analysis was performed. Studies that evaluated the use of endoscopic vacuum therapy for anastomotic leak in esophagectomy and total gastrectomy were included. Twenty-three articles were included. A total of 559 patients were evaluated. Endoscopic vacuum therapy showed a fistulous orifice closure rate of 81.6% (rate: 0.816; 95% CI: 0.777-0.864) and, when compared to the stent, there is a 16% difference in favor of endoscopic vacuum therapy (risk difference [RD]: 0.16; 95% CI: 0.05-0.27). The risk for mortality in the endoscopic vacuum therapy was 10% lower than in endoluminal stent therapy (RD: -0.10; 95% CI: -0.18 to -0.02). Endoscopic vacuum therapy might have a higher rate of fistulous orifice closure and a lower rate of mortality, compared to intraluminal stenting.
C1 [Tavares, Guilherme; Tustumi, Francisco; Tristao, Luca Schiliro; Bernardo, Wanderley Marques] Ctr Univ Lusiada, Dept Evidence Based Med, Sao Paulo, Brazil.
   [Tustumi, Francisco; Bernardo, Wanderley Marques] Univ Sao Paulo, Dept Evidence Based Med, Sao Paulo, Brazil.
   [Tustumi, Francisco] Hosp Israelita Albert Einstein, Dept Surg, Sao Paulo, Brazil.
C3 Centro Universitario Lusiada; Universidade de Sao Paulo; Hospital
   Israelita Albert Einstein
RP Tavares, G (通讯作者)，St Carolino Rodrigues 17, BR-1055070 Santos, SP, Brazil.
EM tavaresguilherme18@gmail.com
RI Tustumi, Francisco/K-4992-2017; Tavares, Guilherme/AAV-4804-2020;
   Schiliró Tristão, Luca/W-8257-2019
OI Tustumi, Francisco/0000-0001-6695-0496; Orlandini,
   Marina/0000-0002-9157-6536; Tavares, Guilherme/0000-0001-6208-3743;
   Schiliró Tristão, Luca/0000-0002-7197-0915
FU Centro Universitario Lusiada (UNILUS)
FX This research was funded by Centro Universitario Lusiada (UNILUS).
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NR 56
TC 40
Z9 47
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAY
PY 2021
VL 34
IS 5
AR doaa132
DI 10.1093/dote/doaa132
EA JAN 2021
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SP1NZ
UT WOS:000659440200006
PM 33479749
DA 2026-07-24
ER

PT J
AU Tribble, DR
   Lewandowski, LR
   Potter, BK
   Petfield, JL
   Stinner, DJ
   Ganesan, A
   Krauss, M
   Murray, CK
AF Tribble, David R.
   Lewandowski, Louis R.
   Potter, Benjamin K.
   Petfield, Joseph L.
   Stinner, Daniel J.
   Ganesan, Anuradha
   Krauss, Margot
   Murray, Clinton K.
CA Trauma Infect Dis Outcomes Study
TI Osteomyelitis Risk Factors Related to Combat Trauma Open Tibia
   Fractures: A Case-Control Analysis
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE osteomyelitis; open fractures; tibia; trauma infection
ID FACTORS INFLUENCING INFECTION; PRESSURE WOUND THERAPY; OPERATIONS IRAQI;
   MANAGEMENT; CLASSIFICATION; COMPLICATIONS; PREVENTION; INJURIES;
   AMPUTATION; CASUALTIES
AB Objectives: We assessed osteomyelitis risk factors in US military personnel with combat-related open tibia fractures (2003-2009).
   Methods: Patients with open tibia fractures who met the diagnostic criteria of osteomyelitis were identified as cases using Military Health System data and verified through medical record review. Controls were patients with open tibia fractures who did not meet osteomyelitis criteria. The Gustilo-Andersen fracture classification scheme was modified to include transtibial amputations (TTAs) as the most severe level. Logistic regression multivariable odds ratios [ORs; 95% confidence intervals (CI)] were assessed.
   Results: A total of 130 tibia osteomyelitis cases and 85 controls were identified. Excluding patients with TTAs, osteomyelitis cases had significantly longer time to radiographic union compared with controls (median: 210 vs. 165 days). Blast injuries, antibiotic bead utilization, >= Gustilo-Andersen-IIIb fractures [highest risk with TTA (OR: 15.10; CI: 3.22-71.07)], and foreign body at the fracture site were significantly associated with developing osteomyelitis. In a separate model, the Orthopaedic Trauma Association Open Fracture Classification muscle variable was significant with increasing risk from muscle loss (OR: 5.62; CI: 2.21-14.25) to dead muscle (OR: 8.46; CI: 3.31-21.64). When TTAs were excluded, significant risk factors were similar and included sustaining an injury between 2003 and 2006.
   Conclusions: Patients with severe blast trauma resulting in significant muscle damage are at the highest risk for osteomyelitis. The period association coincides with a time frame when several trauma system practice changes were initiated (eg, increased negative pressure wound therapy, decreased high-pressure irrigation, and reduced crystalloid use).
C1 [Tribble, David R.; Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Lewandowski, Louis R.; Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA.
   [Petfield, Joseph L.; Stinner, Daniel J.; Murray, Clinton K.] San Antonio Mil Med Ctr, San Antonio, TX USA.
   [Ganesan, Anuradha] Walter Reed Natl Mil Med Ctr, Infect Dis, Bethesda, MD USA.
   [Ganesan, Anuradha] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
   [Krauss, Margot] Westat Corp, Rockville, MD USA.
C3 Uniformed Services University of the Health Sciences - USA; Walter Reed
   National Military Medical Center; Uniformed Services University of the
   Health Sciences - USA; Brooke Army Medical Center; Walter Reed National
   Military Medical Center; Henry M. Jackson Foundation for the Advancement
   of Military Medicine, Inc; Westat
RP Tribble, DR (通讯作者)，Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Infect Dis Clin Res Program, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM David.Tribble@usuhs.edu
RI Stinner, Daniel/KSM-9513-2024; Potter, Benjamin/U-1769-2019
OI Stinner, Daniel/0000-0002-8981-6262; Petfield,
   Joseph/0000-0002-4488-1247
FU NIAID NIH HHS [Y01 AI005072] Funding Source: Medline
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NR 47
TC 16
Z9 22
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2018
VL 32
IS 9
BP E344
EP E353
DI 10.1097/BOT.0000000000001225
PG 10
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA HB8QY
UT WOS:000451356800002
PM 29878946
DA 2026-07-24
ER

PT J
AU Seternes, A
   Rekstad, LC
   Mo, S
   Klepstad, P
   Halvorsen, DL
   Dahl, T
   Björck, M
   Wibe, A
AF Seternes, A.
   Rekstad, L. C.
   Mo, S.
   Klepstad, P.
   Halvorsen, D. L.
   Dahl, T.
   Bjorck, M.
   Wibe, A.
TI Open Abdomen Treated with Negative Pressure Wound Therapy: Indications,
   Management and Survival
SO WORLD JOURNAL OF SURGERY
LA English
DT Article; Proceedings Paper
CT 7th World Congress on the Abdominal Compartment Syndrome
CY MAY, 2015
CL Ghent, BELGIUM
ID ABDOMINAL COMPARTMENT SYNDROME; MEDIATED FASCIAL TRACTION;
   INTRAABDOMINAL HYPERTENSION; CLOSURE; VACUUM; CLASSIFICATION; TRAUMA;
   ETAPPENLAVAGE; DECOMPRESSION; LAPAROTOMY
AB Open abdomen treatment (OAT) is a significant burden for patients and is associated with considerable mortality. The primary aim of this study was to report survival and cause of mortality after OAT. Secondary aims were to evaluate length of stay (LOS) in intensive care unit (ICU) and in hospital, time to abdominal closure and major complications.
   Retrospective review of prospectively registered patients undergoing OAT between October 2006 and June 2014 at Trondheim University Hospital, Norway.
   The 118 patients with OAT had a median age of 63 (20-88) years. OAT indications were abdominal compartment syndrome (ACS) (n = 53), prophylactic (n = 29), abdominal contamination/second look laparotomy (n = 22), necrotizing fasciitis (n = 7), hemorrhage packing (n = 4) and full-thickness wound dehiscence (n = 3). Eight percent were trauma patients. Vacuum-assisted wound closure (VAWC) with mesh-mediated traction (VAWCM) was used in 92 (78 %) patients, the remaining 26 (22 %) had VAWC only. Per-protocol primary fascial closure rate was 84 %. Median time to abdominal closure was 12 days (1-143). LOS in the ICU was 15 (1-89), and in hospital 29 (1-246) days. Eighty-one (68 %) patients survived the hospital stay. Renal failure requiring renal replacement therapy (RRT) (OR 3.9, 95 % CI 1.37-11.11), ACS (OR 3.1, 95 % CI 1.19-8.29) and advanced age (OR 1.045, 95 % CI 1.004-1.088) were independent predictors of mortality in multivariate analysis. The nine patients with an entero-atmospheric fistula (EAF) survived.
   Two-thirds of the patients treated with OAT survived. Renal failure with RRT, ACS and advanced age were predictors of mortality, whereas EAF was not associated with increased mortality.
C1 [Seternes, A.; Dahl, T.] Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Rekstad, L. C.; Wibe, A.] Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Mo, S.; Klepstad, P.] Univ Trondheim Hosp, St Olavs Hosp, Dept Anesthesiol, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Mo, S.; Klepstad, P.] Univ Trondheim Hosp, St Olavs Hosp, Dept Intens Care Med, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Halvorsen, D. L.] Univ Trondheim Hosp, St Olavs Hosp, Dept Urol Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.
   [Bjorck, M.] Uppsala Univ, Vasc Surg Sect, Dept Surg Sci, S-75185 Uppsala, Sweden.
   [Seternes, A.; Wibe, A.] Norwegian Univ Sci & Technol NTNU, Dept Canc Res, Hogskoleringen 1, N-7491 Trondheim, Norway.
   [Seternes, A.; Wibe, A.] Norwegian Univ Sci & Technol NTNU, Dept Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.
   [Seternes, A.; Klepstad, P.; Dahl, T.] Norwegian Univ Sci & Technol NTNU, Dept Circulat, N-7006 Trondheim, Norway.
   [Seternes, A.; Klepstad, P.; Dahl, T.] Norwegian Univ Sci & Technol NTNU, Dept Med Imaging, N-7006 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); Norwegian University of Science & Technology (NTNU);
   Uppsala University; Norwegian University of Science & Technology (NTNU);
   Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU)
RP Seternes, A (通讯作者)，Univ Trondheim Hosp, St Olavs Hosp, Dept Vasc Surg, Prinsesse Kristinas Gate 3, N-7006 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Canc Res, Hogskoleringen 1, N-7491 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Mol Med, Hogskoleringen 1, N-7491 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Circulat, N-7006 Trondheim, Norway.; Seternes, A (通讯作者)，Norwegian Univ Sci & Technol NTNU, Dept Med Imaging, N-7006 Trondheim, Norway.
EM Arne.seternes@stolav.no; Lars.C.Rekstad@stolav.no; Skule.Mo@stolav.no;
   Pal.Klepstad@ntnu.no; Dag.Linthoe.Halvorsen@stolav.no;
   Torbjorn.Dahl@stolav.no; Martin.Bjorck@surgsci.uu.se; Arne.Wibe@ntnu.no
FU St. Olavs Hospital
FX Main investigator received unrestricted grants from St. Olavs Hospital.
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NR 49
TC 23
Z9 33
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JAN
PY 2017
VL 41
IS 1
BP 152
EP 161
DI 10.1007/s00268-016-3694-8
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA EI0EY
UT WOS:000392147000023
PM 27541031
DA 2026-07-24
ER

PT J
AU Trinh, SM
   Andre, K
   Özcan, AI
   Vitharana, DS
   Deville, PE
   Mason, JW
   Hunt, JP
   Marr, AB
   Greiffenstein, PP
   Stuke, LE
   Smith, AA
AF Trinh, Sophia M.
   Andre, Kaitlyn
   Ozcan, Ada I.
   Vitharana, Dhanushka S.
   Deville, Paige E.
   Mason, Joseph W.
   Hunt, John P.
   Marr, Alan B.
   Greiffenstein, Patrick P.
   Stuke, Lance E.
   Smith, Alison A.
TI Surgical management of stage 3 and 4 pressure injuries in trauma
   patients using ovine forestomach matrix grafts: a prospective case
   series
SO FRONTIERS IN SURGERY
LA English
DT Article
DE ovine forestomach matrix; pressure injury; surgical reconstruction;
   trauma; wound healing
ID WOUNDS
AB Introduction Stage 3 and 4 pressure injuries (PIs) pose significant challenges in trauma patients. Surgical management aims to support improvements in tissue vitality and often relies on debridement and negative pressure wound therapy. The use of ovine forestomach matrix (OFM)-based grafts to augment existing surgical approaches may improve tissue quality prior to reconstruction or closure by secondary intention.Methods This prospective observational study is part of a larger Institutional Review Board-approved study (Registry: ClinicalTrials.gov. Clinical trial number: NCT05243966). The study enrolled patients with Stage 3 and 4 PIs between July 2022 and July 2024 at a single level 1 trauma center. The study's primary endpoint was the incidence of postoperative complications and secondary endpoints included time to granulation tissue coverage and/or fill, percent area reduction, and number of OFM applications.Results Nine participants (eight men, one woman) with a total of 12 PIs (25% Stage 3 and 75% Stage 4) were enrolled in the study. The mean surface area was 46 +/- 24 cm2, and 10 of the 12 enrolled PIs included areas of tunneling and/or undermining. The median time to 50% granulation tissue was 2.0 (IQR: 1.5, 8.5) weeks and the median time to complete granulation tissue coverage was 6.5 (IQR: 2.0, 15.0) weeks. Tunneling or undermining was eradicated in 50% of PIs. The mean percent area reduction at the last recorded visit was 61% +/- 30%. There were no postoperative complications.Conclusion These results suggest that OFM-based grafts may serve as a valuable adjunct for the surgical management of late-stage PIs that are clinically challenging to heal.
C1 [Trinh, Sophia M.; Andre, Kaitlyn; Ozcan, Ada I.; Vitharana, Dhanushka S.; Deville, Paige E.; Mason, Joseph W.; Hunt, John P.; Marr, Alan B.; Greiffenstein, Patrick P.; Stuke, Lance E.; Smith, Alison A.] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, New Orleans, LA 70802 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Smith, AA (通讯作者)，Louisiana State Univ, Hlth Sci Ctr, Dept Surg, New Orleans, LA 70802 USA.
EM alison.annette.smith@gmail.com
FU Aroa Biosurgery Limited (Auckland, New Zealand)
FX The author(s) declared that financial support was received for this work
   and/or its publication. Funding for the prospective registry
   (NCT05243966) is provided by Aroa Biosurgery Limited (Auckland, New
   Zealand). The funder was not involved in the study design, collection,
   analysis, interpretation of data, the writing of this article, or the
   decision to submit it for publication.
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD APR 20
PY 2026
VL 13
AR 1704665
DI 10.3389/fsurg.2026.1704665
EA APR 2026
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI5RJ
UT WOS:001754893700001
PM 42087918
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Newman-Hung, NJ
   Shah, AA
   Kendal, JK
   Bernthal, NM
   Wessel, LE
AF Newman-Hung, Nicole J.
   Shah, Akash A.
   Kendal, Joseph K.
   Bernthal, Nicholas M.
   Wessel, Lauren E.
CA PARITY Investigators
TI Machine learning prediction of early reoperation following lower
   extremity tumor resection and endoprosthetic reconstruction: A PARITY
   trial secondary analysis
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Tumor resection; Endoprosthetic reconstruction; Reoperation; Machine
   learning; Prediction
ID PERIPROSTHETIC JOINT INFECTION; KNEE ARTHROPLASTY; RISK-FACTORS; HIP;
   SURGERY; MODELS
AB Background Oncologic resection and endoprosthetic reconstruction of malignant bone tumors carries a high risk of complication and secondary surgery. Given the significant morbidity associated with reoperation in systemically compromised patients, accurate risk stratification is critical to patient counseling and shared decision-making. The purpose of this study was to develop a machine learning (ML) model for prediction of reoperation within one year of lower extremity tumor resection and endoprosthetic reconstruction. Methods Using data from the PARITY trial, 54 features across 604 lower extremity endoprosthetic reconstructions were evaluated as predictors of all-cause reoperation within one year. Logistic regression (LR), Random Forest, gradient boosting, AdaBoost, and XGBoost were used for model building. Standard metrics of area under receiver operating characteristic curve (AUROC), area under the precision-recall curve (AUPRC), and Brier scores were used to evaluate model performance. Important features for the top-performing model were determined. Results Of 604 lower extremity endoprosthetic reconstructions performed in the study period, 155 patients (25.7%) underwent at least one reoperation. The Gradient Boosting model had the highest discrimination (AUROC = 0.817, AUPRC = 0.690) of the tested models and was well-calibrated. Surgical site infection (SSI), operative time, white race, negative pressure wound therapy (NPWT) use, and female sex were the five most important features for model performance. Conclusions We report a well-calibrated ML-driven algorithm with high discriminatory power for the prediction of all-cause early reoperation following lower extremity tumor resection and endoprosthetic reconstruction. Preventing SSI remains paramount to avoiding the morbidity of reoperation after complex oncologic limb salvage surgeries.
C1 [Newman-Hung, Nicole J.; Shah, Akash A.; Bernthal, Nicholas M.; Wessel, Lauren E.] Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA 90095 USA.
   [Kendal, Joseph K.] Univ Calgary, Dept Surg, Div Orthopaed Surg, Calgary, AB, Canada.
   [Newman-Hung, Nicole J.] 15th St,Suite 3140, Santa Monica, CA 90404 USA.
C3 University of California System; University of California Los Angeles;
   University of Calgary
RP Newman-Hung, NJ (通讯作者)，Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA 90095 USA.; Newman-Hung, NJ (通讯作者)，15th St,Suite 3140, Santa Monica, CA 90404 USA.
EM nhung@mednet.ucla.edu
RI Kendal, Joseph/JNE-3674-2023
FU NIAMS NIH HHS [T32 AR059033] Funding Source: Medline
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NR 55
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD AUG 4
PY 2025
VL 20
IS 1
AR 727
DI 10.1186/s13018-025-06139-7
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5TY6J
UT WOS:001544269200001
PM 40759961
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Song, XL
   Zhao, S
   Wang, FY
   Liu, Y
   Wang, L
   Xu, YL
   Lv, L
   Duan, WX
   Zhang, HJ
   Bai, RZ
   Sun, HJ
   Shao, XZ
AF Song, Xiaoliang
   Zhao, Shuo
   Wang, Fengyu
   Liu, Yuan
   Wang, Li
   Xu, Yali
   Lv, Li
   Duan, Wenxu
   Zhang, Hongjuan
   Bai, Runze
   Sun, Hejun
   Shao, Xinzhong
TI Application of Human Acellular Dermal Matrix with Skin Graft for Lacunar
   Soft-Tissue Defect of Lateral Heel after Calcaneal Fracture
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE calcaneal fracture; cellular and/or tissue-based product; heel; human
   acellular dermal matrix; lacunar soft tissue defects; split-thickness
   skin graft; surgery; wound healing
ID PRESSURE WOUND THERAPY; COMPLICATIONS
AB OBJECTIVE: To investigate the clinical effect of human acellular dermal matrix (HADM) combined with split-thickness skin graft in repairing lacunar soft tissue defects of the lateral heel after calcaneal fracture. METHODS: From June 2018 to October 2020, providers repaired 11 cases of lacunar soft tissue defects at the lateral part of the heel using HADM combined with split-thickness skin graft. After thorough debridement, the HADM was trimmed and filled into the lacunar defect area. Once the wound was covered, a split-thickness skin graft and negative-pressure wound therapy were applied. Providers evaluated the appearance, scar, ductility of the skin graft site, appearance of the donor site, healing time, and any reoperation at follow-up. RESULTS: Of the 11 cases, 8 patients achieved successful wound healing by primary intention. Three patients showed partial necrosis in the edge of the skin graft, but the wound healed after standard wound care. Evaluation at 6 and 12 months after surgery showed that all patients had wound healing and mild local scarring; there was no obvious pigmentation or scar formation in the donor skin area. The average healing time was 37.5 days (range, 24-43 days). CONCLUSIONS: The HADM combined with split-thickness skin graft is a simple and effective reconstruction method for lacunar soft tissue defect of the lateral heel after calcaneal fracture. In this small sample, the combination demonstrated few infections, minor scar formation, few donor site complications, and relatively short hospital stays.
C1 [Song, Xiaoliang] Second Peoples Hosp Changzhi City, Orthoped Trauma Dept, Taiyuan, Shanxi, Peoples R China.
   [Zhao, Shuo] Hebei Childrens Hosp, Orthoped Dept, Shijiazhuang, Heibei, Peoples R China.
   [Wang, Fengyu; Liu, Yuan] Hebei Med Univ, Dept Hand Surg, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yuan] Handan First Hosp, Dept Trauma & Orthoped, Handan, Peoples R China.
C3 Hebei Medical University
RP Song, XL (通讯作者)，Second Peoples Hosp Changzhi City, Orthoped Trauma Dept, Taiyuan, Shanxi, Peoples R China.
EM 591600366@qq.com; zzzozs@163.com; 15511615880@163.com; 85264233@qq.com;
   244514067@qq.com; 69508439@qq.com; budinglvli@163.com;
   duanwenxu86@163.com; zhj18533112606@qq.com; 451839993@qq.com;
   760721271@qq.com; a18533112809@163.com
RI Bai, Runze/IQS-7455-2023
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NR 28
TC 1
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JUN
PY 2024
VL 37
IS 6
BP 8
EP 8
DI 10.1097/ASW.0000000000000149
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA RN7M0
UT WOS:001228407000011
PM 38767429
OA hybrid
DA 2026-07-24
ER

PT J
AU Locatello, LG
   Licci, G
   Maggiore, G
   Gallo, O
AF Locatello, Luca Giovanni
   Licci, Giuseppe
   Maggiore, Giandomenico
   Gallo, Oreste
TI Non-Surgical Strategies for Assisting Closure of Pharyngocutaneous
   Fistula after Total Laryngectomy: A Systematic Review of the Literature
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE head and neck; fistula; complications; non-surgical treatment;
   otorhinolaryngology
ID BOTULINUM-TOXIN-A; PRESSURE WOUND THERAPY; HYPERBARIC-OXYGEN;
   TRANSDERMAL SCOPOLAMINE; SALIVARY FISTULA; CANCER-PATIENTS; NECK-CANCER;
   ORAL-CAVITY; FREE-FLAP; HEAD
AB Background: Pharyngocutaneous fistula (PCF) is a frequent complication after total laryngectomy, with an incidence of up to 65%. Many conservative or invasive approaches are available and the choice among them is usually made on a case-by-case basis. The aim of the present review is to critically summarize the available evidence of the effectiveness of the non-surgical management of PCF. Methods: A systematic review and a meta-analysis of the literature were conducted, according to the PRISMA guidelines. Studies investigating botulinum toxin therapy, scopolamine transdermal patch, hyperbaric oxygen therapy (HBOT), and negative pressure wound therapy (NPWT) were assessed. Complete fistula closure after the initiation of non-surgical treatment was the main outcome. Results: After the application of selection criteria, a total of seven articles and 27 patients were included in the present review. All the eligible studies were descriptive case series, while only one article used a standard group as a comparison. The mean age was 63.3 and 14 patients (51.9%) had previously received RT. The reported comorbidities were diabetes, ischemic heart disease, hypertension, dyslipidemia, COPD, and atrial fibrillation. With a mean healing time of 25.0 days, the overall success rate was 92.6%. Conclusions: Non-surgical treatment of PCF is only based on the experience of small series. Although success rates seem promising, the absence of properly designed comparative studies does not allow us, at present, to identify ideal candidates for these non-invasive management strategies for PCF.
C1 [Locatello, Luca Giovanni; Licci, Giuseppe; Maggiore, Giandomenico; Gallo, Oreste] Careggi Univ Hosp, Dept Otorhinolaryngol, Largo Brambilla 3, I-50134 Florence, Italy.
   [Gallo, Oreste] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence
RP Locatello, LG (通讯作者)，Careggi Univ Hosp, Dept Otorhinolaryngol, Largo Brambilla 3, I-50134 Florence, Italy.
EM locatello.lucagiovanni@gmail.com; giuseppe.licci@unifi.it;
   maggiore2@virgilio.it; oreste.gallo@unifi.it
RI Locatello, Luca Giovanni/AAW-1460-2020; Maggiore,
   Giandomenico/AAA-1846-2021
OI Locatello, Luca Giovanni/0000-0002-1879-5580; Gallo,
   Oreste/0000-0003-3426-7179; Maggiore, Giandomenico/0000-0002-2741-4460
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NR 64
TC 22
Z9 26
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2022
VL 11
IS 1
AR 100
DI 10.3390/jcm11010100
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YS5ZE
UT WOS:000750753800001
PM 35011841
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Aditya, C
   Bukke, SPN
   Anitha, K
   Meeraraje, P
   Goruntla, N
   Yadesa, TM
   Onohuean, H
AF Aditya, Chavan
   Bukke, Sarad Pawar Naik
   Anitha, Kuttiappan
   Meeraraje, Pandhare
   Goruntla, Narayana
   Yadesa, Tadele Mekuriya
   Onohuean, Hope
TI A comprehensive review on diabetic foot ulcer addressing vascular
   insufficiency, impaired immune response, and delayed wound healing
   mechanisms
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE diabetic foot ulcer; immunological responses; macrovascular
   contamination; microvascular; neuropathy
ID QUALITY-OF-LIFE; THERAPY
AB Diabetic foot ulcers (DFUs) continue to represent one of the most significant and costly complications related to diabetes mellitus, posing serious challenges to healthcare systems and resulting in considerable morbidity rates. This narrative review explores the complex pathophysiology of DFUs, focusing on the interplay between peripheral neuropathy, vascular insufficiency, and a weakened immune response, all of which contribute to delayed wound healing. Neuropathy leads to a loss of protective sensation, causing unnoticed repetitive injuries, while both microvascular and macrovascular complications reduce tissue perfusion and hinder angiogenesis. Additionally, immune dysfunction and exaggerated inflammatory responses raise the occurrence of infection and negatively affect the healing process. The clinical manifestation, progression, and key risk factors of DFUs were discussed in this review, emphasizing the importance of early detection, careful foot care, and routine screening in individuals who are at risk. Numerous therapeutic approaches are reviewed, including wound debridement, sophisticated wound dressings, offloading techniques, glycemic control, and adjuvant therapies such as growth factor administration, hyperbaric oxygen therapy, and negative pressure wound therapy. For optimal results, a multidisciplinary team combining of vascular surgeons, podiatrists, endocrinologists, and wound care specialists was included. The analysis also points out that promising advancements in bioengineered skin substitutes, intelligent dressings, and regenerative medicine hold promise for the treatment of DFU in the future. Self-monitoring, appropriate footwear, and patient education are all important components of prevention, which remains a fundamental strategy. In the clinical management of DFUs, this narrative review incorporates the most recent research and highlights the value of proactive, customized, and multidisciplinary approaches.
C1 [Aditya, Chavan; Anitha, Kuttiappan; Meeraraje, Pandhare] Deemed Univ, SVKMs Narsee Monjee Inst Management Studies, Sch Pharm & Technol Management, Dept Pharmacol, Shirpur, Maharashtra, India.
   [Bukke, Sarad Pawar Naik] Kampala Int Univ, Dept Pharmaceut & Pharmaceut Technol, Kampala, Uganda.
   [Goruntla, Narayana; Yadesa, Tadele Mekuriya] Kampala Int Univ, Dept Clin Pharm & Pharm Practice, Kampala, Uganda.
   [Onohuean, Hope] Kampala Int Univ, Dept Pharmacol & Toxicol, Biopharmaceut Unit, Kampala, Uganda.
   [Onohuean, Hope] Kampala Int Univ, Biomol Metagen Endocrine & Trop Dis Res Grp BMETDR, Ishaka Bushenyi, Uganda.
C3 SVKM's NMIMS (Deemed to be University)
RP Bukke, SPN (通讯作者)，Kampala Int Univ, Dept Pharmaceut & Pharmaceut Technol, Kampala, Uganda.; Onohuean, H (通讯作者)，Kampala Int Univ, Dept Pharmacol & Toxicol, Biopharmaceut Unit, Kampala, Uganda.; Onohuean, H (通讯作者)，Kampala Int Univ, Biomol Metagen Endocrine & Trop Dis Res Grp BMETDR, Ishaka Bushenyi, Uganda.
EM drsaradpawar@kiu.ac.ug; onohuean@gmail.com
RI Goruntla, Narayana/B-9946-2018; Onohuean, Hope/ACJ-5617-2022; Yadesa,
   Ph.D., Dr. Tadele/JBJ-7161-2023; Kuttiappan, Anitha/KAM-5797-2024;
   BUKKE, SARAD/KBQ-4357-2024
FU Deanship of Research and Graduate Studies at King Khalid University
   [RGP2/639/46]
FX The authors extend their appreciation to the Deanship of Research and
   Graduate Studies at King Khalid University for support through (Large
   Research Project) Number RGP2/639/46.
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NR 111
TC 10
Z9 12
U1 12
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 12
PY 2025
VL 16
AR 1622055
DI 10.3389/fphar.2025.1622055
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA F5290
UT WOS:001623632500001
PM 41311850
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Powell, AGMT
   Crozier, JEM
   Hodgson, H
   Galloway, DJ
AF Powell, Arfon G. M. T.
   Crozier, Joseph E. M.
   Hodgson, Heather
   Galloway, David J.
TI A case of septicaemic anthrax in an intravenous drug user
SO BMC INFECTIOUS DISEASES
LA English
DT Article
ID INHALATIONAL ANTHRAX; HEROIN; BIOTERRORISM; INFECTION; SURVIVAL;
   OUTBREAK; GLASGOW; COHORT
AB Background: In 2000, Ringertz et al described the first case of systemic anthrax caused by injecting heroin contaminated with anthrax. In 2008, there were 574 drug related deaths in Scotland, of which 336 were associated with heroin and or morphine. We report a rare case of septicaemic anthrax caused by injecting heroin contaminated with anthrax in Scotland.
   Case Presentation: A 32 year old intravenous drug user (IVDU), presented with a 12 hour history of increasing purulent discharge from a chronic sinus in his left groin. He had a tachycardia, pyrexia, leukocytosis and an elevated C-reactive protein (CRP). He was treated with Vancomycin, Clindamycin, Ciprofloxacin, Gentamicin and Metronidazole. Blood cultures grew Bacillus anthracis within 24 hours of presentation. He had a computed tomography (CT) scan and magnetic resonance imagining (MRI) of his abdomen, pelvis and thighs performed. These showed inflammatory change relating to the iliopsoas and an area of necrosis in the adductor magnus. He underwent an exploration of his left thigh. This revealed chronically indurated subcutaneous tissues with no evidence of a collection or necrotic muscle. Treatment with Vancomycin, Ciprofloxacin and Clindamycin continued for 14 days. Negative Pressure Wound Therapy (NPWT) device was applied utilising the Venturi T wound sealing kit. Following 4 weeks of treatment, the wound dimensions had reduced by 77%.
   Conclusions: Although systemic anthrax infection is rare, it should be considered when faced with severe cutaneous infection in IVDU patients. This case shows that patients with significant bacteraemia may present with no signs of haemodynamic compromise. Prompt recognition and treatment with high dose IV antimicrobial therapy increases the likelihood of survival. The use of simple wound therapy adjuncts such as NPWT can give excellent wound healing results.
C1 [Powell, Arfon G. M. T.; Crozier, Joseph E. M.; Galloway, David J.] Gartnavel Royal Hosp, Dept Surg Gastroenterol, Glasgow, Lanark, Scotland.
C3 Gartnavel Royal Hospital
RP Powell, AGMT (通讯作者)，Gartnavel Royal Hosp, Dept Surg Gastroenterol, Glasgow, Lanark, Scotland.
EM arfonpowell@doctors.org.uk
RI Powell, Arfon/H-6794-2019
OI Powell, Arfon/0000-0002-3740-8275
CR [Anonymous], DRUG REL DEATHS SCOT
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NR 24
TC 23
Z9 26
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JAN 20
PY 2011
VL 11
AR 21
DI 10.1186/1471-2334-11-21
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 717ZA
UT WOS:000287086600001
PM 21251266
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wen, YW
   Wang, CH
   Jia, HT
   Liu, T
   Yu, JZ
   Zhang, MY
AF Wen, Yuwei
   Wang, Chunhua
   Jia, Haiting
   Liu, Tao
   Yu, Jiazhi
   Zhang, Mengyuan
TI Comparison of diagnosis and treatment of MSSA and MRSA osteomyelitis in
   children: a case-control study of 64 patients
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Osteomyelitis; Methicillin-resistant Staphylococcus aureus; Drug
   resistance; Microbial; Child
ID ACUTE HEMATOGENOUS OSTEOMYELITIS; PEDIATRIC MUSCULOSKELETAL INFECTION;
   RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT
AB BackgroundWe aimed to compare the clinical characteristics of acute osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in children.MethodsWe retrospectively analyzed the data of 64 children treated between September 2017 and June 2021. Based on the bacterial culture results, they were divided into MRSA and MSSA infection groups. Both groups were treated with debridement and vacuum-assisted closure for negative pressure drainage. Parameters including clinical manifestations, number of operations, length of hospital stay, inflammatory indicators, and concurrent arthritis were compared between the two groups.ResultsIn the MRSA infection group, there was one case each of residual joint stiffness and pathological fracture. Conversely, the MSSA group had two cases of residual joint stiffness. The MRSA infection group was more prone to high fever (t = 3.61, P = 0.001), white blood cell count elevation (t = 2.41, P = 0.022), arthritis (X-2 = 7.48, P = 0.013), metastatic abscess (X-2 = 4.78, P = 0.042), and a shorter length of progression from onset to admission (t = - 2.04, P = 0.046); however, it required more surgeries (t = 2.68, P = 0.009) and longer hospital stay (t = 2.04, P = 0.045).ConclusionsPediatric acute osteomyelitis caused by MRSA is more prone to cause high fever and markedly elevated of white blood cell count, and is often accompanied with suppurative infection of adjacent joints and metastatic abscesses, thus requiring more surgeries and longer hospital stay.
C1 [Wen, Yuwei] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Orthopaed, 56 Nalishi Rd, Beijing 100045, Peoples R China.
   [Wang, Chunhua; Jia, Haiting; Liu, Tao; Yu, Jiazhi] Shandong Univ, Childrens Hosp, Jinan Childrens Hosp, Dept Orthopaed Trauma Surg, 23976 Jingshi Rd, Jinan 250022, Shandong, Peoples R China.
   [Zhang, Mengyuan] Dept Peking Union Med Coll, Class 2025, Beijing 100730, Peoples R China.
C3 Capital Medical University; Shandong University
RP Wang, CH (通讯作者)，Shandong Univ, Childrens Hosp, Jinan Childrens Hosp, Dept Orthopaed Trauma Surg, 23976 Jingshi Rd, Jinan 250022, Shandong, Peoples R China.
EM wchxewk@126.com
FU National Key R&D Program of China [2020YFC1107604] Funding Source:
   Medline
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NR 24
TC 8
Z9 11
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD MAR 13
PY 2023
VL 18
IS 1
AR 197
DI 10.1186/s13018-023-03670-3
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 9X5KZ
UT WOS:000949810000006
PM 36915118
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, SJ
   Duan, Q
   Xue, YJ
   She, LL
   Xia, Y
   Lin, JL
AF Wang, Sun-Jian
   Duan, Qing
   Xue, Yun-Jing
   She, Li-Lan
   Xia, Yu
   Lin, Ju-Li
TI Short-term outcomes of a new gastrointestinal decompression tube
   combined with conservative treatment in patients with esophagojejunal
   anastomotic leakage after total gastrectomy
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article
DE Gastric cancer; Esophagojejunal anastomotic leakage; Conservative
   treatment; New gastrointestinal decompression tube
ID VACUUM-ASSISTED CLOSURE; RESECTION; SURVIVAL; IMPACT; STENT
AB To compare the short-term outcomes of a new gastrointestinal decompression tube combined with conservative treatment in patients with esophagojejunal anastomotic leakage (EJAL) after total gastrectomy. We retrospectively analyzed the data of 81 patients with EJAL who had undergone total gastrectomy and Roux-en-Y reconstruction at Fujian Medical University Union Hospital between January 2014 and December 2021. The patients were divided into experimental (12 patients with new gastrointestinal decompression tube plus conservative treatment) and control (69 patients with conservative treatment) groups, according to the different treatment methods they received. Anatomic defect size linearly correlated with time to clinical success, hospital stay, and hospital cost in the control group. The two groups showed no significant differences in anastomotic defect size, time of defect after surgery, hospitalization cost, and time of antibiotic use. However, the time to clinical success was significantly shorter in the experimental group than in the control group (16.0 +/- 8.3 vs. 23.6 +/- 17.8, P = 0.04), as was the length of hospital stay (30.1 +/- 6.3 vs. 36.8 +/- 16.7, P = 0.017). Furthermore, when the defect size was >= 4 mm, the time to clinical success, hospital stay, and hospital cost in the experimental group were lower than those in the control group (P < 0.05). Placement of a new gastrointestinal decompression tube is a safe treatment. When the defect size is >= 4 mm, the time to clinical success, length of hospital stay, and hospital cost can be reduced.
C1 [Wang, Sun-Jian; Duan, Qing; Xue, Yun-Jing; She, Li-Lan; Xia, Yu] Fujian Med Univ Union Hosp, Dept Radiol, Fuzhou, Fujian, Peoples R China.
   [Lin, Ju-Li] Fujian Med Univ Union Hosp, Dept Gastr Surg, 29 Xin Quan Rd, Fuzhou 350001, Peoples R China.
C3 Fujian Medical University; Fujian Medical University
RP Lin, JL (通讯作者)，Fujian Med Univ Union Hosp, Dept Gastr Surg, 29 Xin Quan Rd, Fuzhou 350001, Peoples R China.
EM 632366024@qq.com
OI Lin, Juli/0000-0002-6518-9372
FU Fujian provincial health technology project [2019-1-26]; Fujian
   provincial social development science and technology guiding project
   [2022Y01010238]
FX Sponsored by Fujian provincial health technology project (2019-1-26);
   Sponsored by Fujian provincial social development science and technology
   guiding project, (2022Y01010238).
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NR 18
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD MAR
PY 2023
VL 37
IS 3
BP 1799
EP 1805
DI 10.1007/s00464-022-09694-w
EA OCT 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA F7PN7
UT WOS:000867539000007
PM 36229555
DA 2026-07-24
ER

PT J
AU Kaczmarek, DJ
   Heling, DJ
   Gonzalez-Carmona, MA
   Strassburg, CP
   Branchi, V
   Matthaei, H
   Kalff, J
   Manekeller, S
   Glowka, TR
   Weismüller, TJ
AF Kaczmarek, Dominik J.
   Heling, Dominik J.
   Gonzalez-Carmona, Maria A.
   Strassburg, Christian P.
   Branchi, Vittorio
   Matthaei, Hanno
   Kalff, Joerg
   Manekeller, Steffen
   Glowka, Tim R.
   Weismueller, Tobias J.
TI Management of post-operative pancreatic fistulas following
   Longmire-Traverso pylorus-preserving pancreatoduodenectomy by endoscopic
   vacuum-assisted closure therapy
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Endo-sponge; Endoscopic vacuum-assisted wound closure system;
   Anastomotic leakage; Pancreaticogastric anastomotic insufficiency;
   Pancreaticogastrostomy
ID FLUID COLLECTIONS; PANCREATICOJEJUNOSTOMY; PANCREATICOGASTROSTOMY;
   RECONSTRUCTION; DRAINAGE; ESOPHAGEAL; LEAKAGE; RISK;
   PANCREATOGASTROSTOMY; PANCREATOJEJUNOSTOMY
AB Background Pylorus-preserving pancreatoduodenectomy (PPPD) with pancreatogastrostomy is a standard surgical procedure for pancreatic head tumors, duodenal tumors and distal cholangiocarcinomas. Post-operative pancreatic fistulas (POPF) are a major complication causing relevant morbidity and mortality. Endoscopic vacuum therapy (EVT) has become a widely used method for the treatment of intestinal perforations and leakages. Here we report on a pilot single center series of 8 POPF cases specifically caused by dehiscences of the pancreatogastric anastomosis (PGD), successfully managed by EVT. Methods We included all patients with PGD after PPPD, who were treated with EVT between 07/2017 and 08/2020. For EVT a vacuum drainage film (EVT film) or open-pore polyurethane foam sponge (EVT sponge) was fixed to a 14Fr or 16Fr suction catheter and placed endoscopically within the PGD for intracavitary EVT with continuous suction between - 100 and - 150 mmHg. The EVT film/sponge was exchanged twice per week. EVT was discontinued when the PGD was sufficiently healed. Results PGD closure was achieved in 7 of 8 patients after a mean EVT time of 16 days (range 8-38) and 3 EVT film/sponge exchanges (range 1-9). One patient died on day 18 after PPPD from acute hemorrhagic shock, unlikely related to EVT, before effectiveness of EVT could be fully achieved. There were no adverse events directly attributable to EVT. Conclusions EVT could be an effective and safe addition to our therapeutic armamentarium in the management of POPF with PGD. Unless prospective comparative studies are available, EVT as minimally invasive therapeutic alternative should be considered individually by an interdisciplinary team involving endoscopists, surgeons and radiologists.
C1 [Kaczmarek, Dominik J.; Heling, Dominik J.; Gonzalez-Carmona, Maria A.; Strassburg, Christian P.; Weismueller, Tobias J.] Univ Bonn, Dept Internal Med 1, Bonn, Germany.
   [Branchi, Vittorio; Matthaei, Hanno; Kalff, Joerg; Manekeller, Steffen; Glowka, Tim R.] Univ Bonn, Dept Gen Visceral Thorac & Vasc Surg, Bonn, Germany.
   [Weismueller, Tobias J.] Vivantes Humboldt Hosp, Dept Internal Med Gastroenterol & Oncol, Nordgraben 2, D-13509 Berlin, Germany.
C3 University of Bonn; University of Bonn; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Weismüller, TJ (通讯作者)，Univ Bonn, Dept Internal Med 1, Bonn, Germany.; Weismüller, TJ (通讯作者)，Vivantes Humboldt Hosp, Dept Internal Med Gastroenterol & Oncol, Nordgraben 2, D-13509 Berlin, Germany.
EM Tobias.Weismueller@gmx.de
RI Weismüller, Tobias J/I-1879-2019; Glowka, Tim R/AAW-6804-2021; Kalff,
   Joerg/U-8580-2017
OI Weismüller, Tobias J/0000-0001-9736-1483; Glowka, Tim
   R/0000-0001-6996-9766; 
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 46
TC 11
Z9 11
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD NOV 12
PY 2021
VL 21
IS 1
AR 425
DI 10.1186/s12876-021-02000-3
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WW5VC
UT WOS:000717982900003
PM 34772366
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chen, WJ
   Guo, H
   Chen, G
   Wang, WB
   Zhang, TP
AF Chen, Wei-Jie
   Guo, Hao
   Chen, Ge
   Wang, Wei-Bin
   Zhang, Tai-Ping
TI Successful control of high-flow output enterocutaneous fistula wound
   with an innovative self-manufactured plug
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE case report; high-flow output enterocutaneous fistula; wound care;
   self-manufactured plug
AB Background: Meticulous wound care is necessary for relieving the suffering of enterocutaneous fistula (ECF) patients and improving the quality of life. Although many approaches to treat the fistula wound have been attempted, wound care before definitive surgery remains a challenge, especially for high-flow output ECF. Cases: In the present study, we report a case of a 77-year-old female with a diagnosis of jejunal fistula 14 days after the Miles surgery. The traditional vacuum assisted closure (VAC) device was initially applied to the patient's wound care. However, the residual enteric fluid out from the fistula irritated skin and brought great pain (Visual Analogue Score 8). Morphine (20-30 mg daily) was used. Besides, the VAC system was replaced nearly every day because skin exudation led to poor airtightness and the evacuation tube was often blocked. In the following month, the wound size didn't change significantly. To reduce bowel fluid irritation and promote wound healing, we established a selfmanufactured plug to occlude the fistula, collect enteric fluid, and protect the wound. The patient did not complain any severe discomfort. No pain killer was used any more (Visual Analogue Score 3). The catheter of the plug collected 500-800 ml enteric fluid per 24 hours without blockade. In addition, all the materials to make the plug are cheap and available in the wards. After approximately 2 weeks of regular wound dressing changes, the fistula wound formed scabs and healed well. Conclusions: We present a case of successful control of high-flow output enterocutaneous fistula wound using an innovative self-manufactured plug. We highly recommend this pain-relieving and cost-effective approach for fistula wound care.
C1 [Chen, Wei-Jie; Guo, Hao; Chen, Ge; Wang, Wei-Bin; Zhang, Tai-Ping] Chinese Acad Med Sci, Dept Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital
RP Zhang, TP (通讯作者)，Chinese Acad Med Sci, Dept Surg, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China.
EM zhangtppumch@163.com
CR Vallejo EC, 2015, DIAGN INTERV RADIOL, V21, P247, DOI 10.5152/dir.2014.14421
   Draus Jr JM, 2006, SURGERY, V140
   Hollington P, 2004, BRIT J SURG, V91, P1646, DOI 10.1002/bjs.4788
   Jr Draus JM, 2006, SURGERY, V140, P570
   Wainstein Daniel Edgardo, 2008, World J Surg, V32, P430
NR 5
TC 0
Z9 0
U1 0
U2 0
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 6
BP 9704
EP 9707
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EZ2JF
UT WOS:000404534900132
DA 2026-07-24
ER

PT J
AU Laje, P
   Hedrick, HL
   Flake, AW
   Adzick, NS
   Peranteau, WH
AF Laje, Pablo
   Hedrick, Holly L.
   Flake, Alan W.
   Adzick, N. Scott
   Peranteau, William H.
TI Delayed abdominal closure after congenital diaphragmatic hernia repair
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the British-Association-of-Paediatric-Surgeons
CY JUL 22-24, 2015
CL Cardiff, WALES
SP British Assoc Paediat Surg
DE Congenital diaphragmatic hernia; Extracorporeal membrane oxygenation;
   Delayed abdominal closure; Open abdomen
ID WALL CLOSURE
AB Purpose: We present our experience with CDH patients who required delayed abdominal closure following CDH repair.
   Methods: A retrospective review of all CDH repairs from 2004 to 2014 was performed.
   Results: 233 patients underwent CDH repair, of which 21 required delayed abdominal closure defined as the inability to close the abdominal fascia at the time of CDH repair. The incidence of delayed closure was higher in those undergoing CDH repair on ECMO vs. not on ECMO(40% [17/43] vs. 2% [4/190]; P < 0.001). The abdominal wound was temporarily covered by skin only (n = 2), skin + prosthetic mesh sutured to the fascia (n = 3), preformed silo (n = 9), or vacuum assisted closure (VAC (R)) device (n = 7). The mean time to fascial closure was 14.5+/-7 and 6+/-3 days for patients repaired on ECMO and not on ECMO, respectively. In patients repaired on ECMO, the "primary closure" and "delayed closure" groups were not different in prenatal predictors (liver up, lung-to-head ratio [LHR]), total days on ECMO, ECMO days prior to CDH repair, and survival. In patients repaired on ECMO, the "delayed closure" group had a significantly higher requirement for blood transfusions compared to the "primary closure" group (mean 87+/-35 vs. 62+/-27 ml of packed RBCs per ECMO day; P=0.01).
   Conclusion: Delayed abdominal closure was required in 40% of CDH repairs done on ECMO but was rarely required in CDH repairs performed off ECMO. Although associated with an increased need for blood transfusions, delayed closure following CDH repair on ECMO was not associated with increased mortality. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Laje, Pablo; Hedrick, Holly L.; Flake, Alan W.; Adzick, N. Scott; Peranteau, William H.] Childrens Hosp Philadelphia, Div Gen Thorac & Fetal Surg, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia
RP Peranteau, WH (通讯作者)，Childrens Hosp Philadelphia, 34th St & Civ Ctr Blvd,Wood Bldg,Off 5100, Philadelphia, PA 19104 USA.
EM peranteauw@email.chop.edu
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Bebbington M, 2014, ULTRASOUND OBST GYN, V43, P670, DOI 10.1002/uog.13271
   Desai AA, 2015, SEMIN PEDIATR SURG, V24, P17, DOI 10.1053/j.sempedsurg.2014.11.004
   Ejike J., 2011, AM SURG, V77, pS72
   Erik G, 2010, J PEDIATR SURG, V45, P1324
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   Gracias VH, 2002, ARCH SURG-CHICAGO, V137, P1298, DOI 10.1001/archsurg.137.11.1298
   Kyzer S, 2004, ARCH SURG-CHICAGO, V139, P296, DOI 10.1001/archsurg.139.3.296
   Maxwell D, 2013, J PEDIATR SURG, V48, P930, DOI 10.1016/j.jpedsurg.2013.02.008
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NR 13
TC 19
Z9 22
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD FEB
PY 2016
VL 51
IS 2
BP 240
EP 243
DI 10.1016/j.jpedsurg.2015.10.069
PG 4
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Surgery
GA DE7JA
UT WOS:000370810800010
PM 26653950
DA 2026-07-24
ER

PT J
AU Walter, G
   Kemmerer, M
   Hoffmann, R
AF Walter, G.
   Kemmerer, M.
   Hoffmann, R.
TI Treatment of Septic Olecranon and Patellar Bursitis by Excision and
   Vacuum-Assisted Closure Therapy
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE septic olecranon bursitis; septic patellar bursitis; total bursectomy
ID ANTIBIOTIC-THERAPY; PREPATELLAR; DIAGNOSIS
AB Background: Treatment of septic olecranon and patellar bursitis differs considerably and is currently under discussion. We therefore performed a retrospective study of our patients with septic bursitis in the past 5 years.
   Patients and Method: Between March 2007 and February 2012 we treated 79 patients with septic olecranon (n = 43) and patellar (n = 36) bursitis surgically: 61-males, 18 females, age 51 (range: 11-91) years. Four patients had not been treated before, 25 had suffered recurrences after 1-10 previous procedures, and 9 patients had not improved after conservative therapy. 34 patients presented with traumatic rupture or fistula of their bursae. In all cases we performed a radical bursectomy and vacuum-assisted therapy for 4 to 5 days. In addition, patients received systemic antibiotics. We phoned all patients and were successful in 57 cases (72%). We questioned these patients for range of movement, limitations at work, pain, sensibility disorder, satisfaction with the result and further surgical procedures. In all cases we took tissue specimens for cultures, in 48 preparations histological examination was performed.
   Results: Microbiological and histological results are discussed in detail. 40 patients were free of complaints, 15 complained of mild pain, 54 of 57 had unlimited range of motion. Minor discomforts at desk work were reported by 5 of 43 patients, 12 out of 36 patient reported discomfort when performing on their knees. There was no recurrence in the period of investigation.
   Conclusion: We recommend our treatment concept for septic olecranon and patellar bursitis because patient satisfaction is high and recurrences are reliably avoided. The soft tissue is spared, so that plastic covering procedures are seldom necessary.
C1 [Walter, G.; Kemmerer, M.] Berufsgenossenschaftliche Unfallklin, Friedberger Landstr 430, D-60389 Frankfurt, Germany.
RP Walter, G (通讯作者)，Berufsgenossenschaftliche Unfallklin, Friedberger Landstr 430, D-60389 Frankfurt, Germany.
EM gerhard.walter@bgu-frankfurt.de
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   Scharf H P, 2009, ORTHOPADIE UNFALLCHI
   Schonberger A, 2009, ARBEITSUNFALL BERUFS
   Weigel B., 2005, Praxisbuch Unfallchirurgie. S. 1162-1166
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NR 18
TC 2
Z9 3
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD AUG
PY 2013
VL 151
IS 4
BP 353
EP 357
DI 10.1055/s-0033-1350612
PG 5
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 203RS
UT WOS:000323311400005
PM 23963983
DA 2026-07-24
ER

PT J
AU Macisaac, MF
   Wright, JM
   Halsey, JN
   Fitzgerald, RE
   Snyder, CW
   Rottgers, SA
AF Macisaac, Molly F.
   Wright, Joshua M.
   Halsey, Jordan N.
   Fitzgerald, Ryan E.
   Snyder, Christopher W.
   Rottgers, S. Alex
TI Management of Pediatric Type III Tibial Shaft Fractures
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE type III tibial fracture; open tibial shaft fracture; pediatrics;
   soft-tissue reconstruction; Gustilo type III; orthopedics
ID SOFT-TISSUE; TRAUMA; FIXATION; CHILDREN; POPULATION; SERIES; BONE
AB Background: Pediatric open tibial fractures represent a challenging subset of injuries with limited literature to guide management. For children, the epidemiology, management, and outcomes of tibial-shaft fractures have not been fully described. Methods: A retrospective analysis of the Trauma Quality Improvement Program Data Bank from 2017-2020 was used to query demographics, injury patterns, and management strategies in pediatric open tibial fractures. Fractures were compared by age group (0-5, 6-12, 13-17 years) and type (I/II vs type III). A subgroup analysis was performed on patients with type III open fractures. Results: A total of 3480 open tibial fractures were identified, 3049 were type I/II, and 431 were type III. Motor vehicle accidents (48%) were the most common mechanism of injury (P < 0.001). Subanalysis of 128 type IIIb/c tibial fractures revealed local flap reconstruction (25%) skin graft (25%), and free tissue transfer were the most common management strategies and soft-tissue coverage was achieved after 162 hours (interquartile range = 109-231). Negative pressure wound therapy was utilized in 63% of cases but used in isolation in only 23% of cases. Immediate fixation with intramedullary nailing was more frequently used in the 13-17 age group while plate fixation was more commonly used in younger age groups. Conclusions: Soft-tissue management patterns following open tibial shaft fractures mirror those seen in adult cohorts. The median time to achieve soft-tissue coverage exceeds the traditional 72-hour target advocated by Godina. Age-based variation is seen in orthopedic management of these fractures based on growth maintenance concerns.
C1 [Macisaac, Molly F.; Wright, Joshua M.; Halsey, Jordan N.; Rottgers, S. Alex] Johns Hopkins All Childrens Hosp, Div Plast & Reconstruct Surg, St Petersburg, FL USA.
   [Fitzgerald, Ryan E.] Johns Hopkins All Childrens Hosp, Div Orthoped Surg, St Petersburg, FL USA.
   [Fitzgerald, Ryan E.] Childrens Orthopaed & Scoliosis Surg Associates LL, St Petersburg, Florida, Uruguay.
   [Snyder, Christopher W.] Johns Hopkins All Childrens Hosp, Dept Pediat Surg, St Petersburg, FL USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine
RP Rottgers, SA (通讯作者)，601 5th St South,Suite 306, St Petersburg, FL 33701 USA.
EM mmacisa1@jh.edu; dr.joshuamwright@gmail.com; jhalsey2@jhmi.edu;
   rfitzg11@jhmi.edu; csnyde21@jhmi.edu; srottge1@jhmi.edu
RI ; Halsey, Jordan/D-2545-2011
OI Wright, Joshua/0000-0003-2225-3247; MacIsaac, Molly/0000-0002-3632-4205;
   
CR Baldwin KD, 2009, J CHILD ORTHOP, V3, P199, DOI 10.1007/s11832-009-0169-6
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   Stenroos A, 2018, SCAND J SURG, V107, P269, DOI 10.1177/1457496917748227
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2024
VL 93
IS 4
BP 501
EP 509
DI 10.1097/SAP.0000000000004102
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H2B5Q
UT WOS:001321545200004
PM 39331748
DA 2026-07-24
ER

PT J
AU Singh, PK
   Sethi, MK
   Mishra, TS
   Kumar, P
   Ali, SM
   Sasmal, PK
   Mishra, SS
AF Singh, Pradeep Kumar
   Sethi, Mahesh Kumar
   Mishra, Tushar Subhadarshan
   Kumar, Pankaj
   Ali, S. Manwar
   Sasmal, Prakash Kumar
   Mishra, Swastik Sourav
TI Comparison of surgical site infection (SSI) between negative pressure
   wound therapy (NPWT) assisted delayed primary closure and conventional
   delayed primary closure in grossly contaminated emergency abdominal
   surgeries: a randomized controlled trial
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE SSI; NPWT; Delayed primary closure; Dirty wound
ID RISK-FACTORS
AB PurposeNPWT has been tried in many surgical fields, including colorectal, thoracic, vascular, and non-healing wounds, for the prevention of SSI. However, its efficacy in the prevention of SSI-grade IV closed abdominal wounds is yet to be explored.MethodsAll patients with grade IV abdominal wounds were included in the study. They were randomized into the conventional arm and the VAC arm after confirming the diagnosis intra-operatively. The sheath was closed, and the skin was laid open in the postoperative period. In the VAC arm, the NPWT dressing was applied on postoperative day (POD)-1 and removed on POD-5. In the conventional arm, only regular dressing was done postoperatively. The skin was closed with a delayed primary intention on POD-5 in both arms. The sutures were removed after 7 to 10 days of skin closure.ResultsThe rate of SSI (10% in the VAC arm vs. 37.5% in the conventional arm, p-value = 0.004) was significantly lower in the VAC arm, as were the rates of seroma formation (2.4% in the VAC arm vs. 20% in the conventional arm, p = 0.014) and wound dehiscence (7.3% vs. 30%, p = 0.011). The conventional arm had a significant delay in skin closure beyond POD5 due to an increased rate of SSI, which also led to a prolonged hospital stay (5 days in the VAC arm vs. 6.5 days in the conventional arm, p-value = 0.005).ConclusionThe VAC dressing can be used routinely in grade IV closed abdominal wounds to reduce the risk of SSI and wound dehiscence.
C1 [Singh, Pradeep Kumar; Sethi, Mahesh Kumar; Mishra, Tushar Subhadarshan; Kumar, Pankaj; Ali, S. Manwar; Sasmal, Prakash Kumar; Mishra, Swastik Sourav] AIIMS Bhubaneswar, Dept Gen Surg, Bhubaneswar, Odisha, India.
C3 All India Institute of Medical Sciences (AIIMS) Bhubaneswar
RP Sethi, MK (通讯作者)，AIIMS Bhubaneswar, Dept Gen Surg, Bhubaneswar, Odisha, India.
EM surg_pradeep@aiimsbhubaneswar.edu.in; maheshsethi949@gmail.com;
   surg_tushar@aiimsbhubaneswar.edu.in;
   surg_pankaj@aiimsbhubaneswar.edu.in;
   surg_manwar@aiimsbhubaneswar.edu.in;
   surg_prakash@aiimsbhubaneswar.edu.in; swmswastik@gmail.com
RI Singh, Pradeep/AGI-4972-2022; MISHRA, TUSHAR/KFS-1512-2024
CR Alkaaki A, 2019, CAN J SURG, V62, P111, DOI 10.1503/cjs.004818
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NR 37
TC 5
Z9 8
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD DEC 27
PY 2023
VL 409
IS 1
AR 19
DI 10.1007/s00423-023-03202-x
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DK1G2
UT WOS:001131833200001
PM 38150073
OA hybrid
DA 2026-07-24
ER

PT J
AU Joomun, MU
   Li, ZY
   Xue, DT
   Shao, HW
   Pan, ZJ
AF Joomun, Muhammad Umar
   Li, Zhiya
   Xue, Deting
   Shao, Huawei
   Pan, Zhijun
TI Idiopathic necrotizing fasciitis following fracture fixation A case
   report
SO MEDICINE
LA English
DT Article
DE diabetes mellitus; idiopathic; intertrochanteric fracture; necrotizing
   fasciitis; wound management
ID SOFT-TISSUE INFECTIONS; DIAGNOSIS; MORTALITY; SCORE
AB Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Patient concerns: A 56-year-old diabetic female presented with multiple fractures. After open reduction and internal fixation (ORIF) with iliac crest grafting of hip fracture, she developed incisional NF which later spread to the abdomen. Diagnosis: Post-ORIF of hip fracture complicated with idiopathic NF and abdominal spread. Interventions: She underwent emergency debridements with negative pressure wound therapy and broad-spectrum intravenous antibiotic therapy. After granulation, the wounds were closed with skin flaps and grafts with antibiotic beads. When the NF spread to the abdomen, additional debridements during abdominal explorations were performed. Outcomes: The patient was initially stable with promising healings of the wounds. Later, the patient suddenly developed a high fever and severe abdominal pain. Ultrasound revealed that NF emerged unexpectedly in the right lower abdomen. The causative agent of the NF remained undetected. Despite all the extensive treatments, the patient's condition deteriorated rapidly. She died of septic shock and multiple organ failure. Conclusion: The idiopathic NF may still potentially occur after a clean ORIF of the hip region. The implementation of intensive guideline-based treatments may show improvements, but the risk of unexpected NF spread to the abdomen should be anticipated, which may increase the mortality rates in diabetic or immunocompromised patients.
C1 [Joomun, Muhammad Umar; Xue, Deting; Pan, Zhijun] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
   [Li, Zhiya] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Emergency, Guangzhou, Guangdong, Peoples R China.
   [Shao, Huawei] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Burns, 88 Jiefang Rd, Hangzhou, Zhejiang, Peoples R China.
   [Shao, Huawei] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Wound Ctr, 88 Jiefang Rd, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Guangzhou University of Chinese Medicine; Zhejiang
   University; Zhejiang University
RP Pan, ZJ (通讯作者)，Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Orthopaed, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM zrpzj@zju.edu.cn
RI shao, huawei/LDF-8346-2024; Pan, Zhijun/AAD-6547-2022
OI JOOMUN, MUHAMMAD UMAR/0000-0002-3956-9531
CR Berkes M, 2010, J BONE JOINT SURG AM, V92A, P823, DOI 10.2106/JBJS.I.00470
   Bucca K, 2013, ANZ J SURG, V83, P365, DOI 10.1111/j.1445-2197.2012.06251.x
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NR 25
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2020
VL 99
IS 26
AR e20874
DI 10.1097/MD.0000000000020874
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM1AE
UT WOS:000549890000069
PM 32590794
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Deutscher, M
   Schillie, S
   Gould, C
   Baumbach, J
   Mueller, M
   Avery, C
   Van Beneden, CA
AF Deutscher, Meredith
   Schillie, Sarah
   Gould, Carolyn
   Baumbach, Joan
   Mueller, Mark
   Avery, Catherine
   Van Beneden, Chris A.
TI Investigation of a Group A Streptococcal Outbreak among Residents of a
   Long-Term Acute Care Hospital
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID CLUSTER; FAMILY
AB Background. In January 2008, a long-term acute care hospital (LTACH) in New Mexico reported a cluster of severe group A Streptococcus (GAS) infections.
   Methods. We defined a case as illness in a patient in the LTACH from 1 October 2007 through 3 February 2008 from whom GAS was isolated from a usually sterile site or with illness consistent with GAS infection and GAS isolated from a nonsterile site. To identify carriers, we swabbed the oropharynx and skin lesions of patients and staff. We observed facility procedures to assess possible transmission routes and adherence to infection control practices. We also conducted a case-control study to identify risk factors for infection with use of asymptomatic patients who were noncarriers as control subjects.
   Results. We identified 11 case patients and 11 carriers (8 patients and 3 staff). No carriers became case patients. Significant risk factors for infection in univariate analysis included sharing a room with an infected or colonized patient (6 [55%] of 11 case patients vs 3 [8%] of 39 control subjects), undergoing wound debridement (64% vs 13%), and receiving negative pressure wound therapy (73% vs 33%). Having an infected or colonized roommate remained associated with case patients in multivariable analysis (odds ratio, 15.3; 95% confidence interval, 2.5-110.9). Suboptimal infection control practices were widespread.
   Conclusions. This large outbreak of GAS infection was the first reported in an LTACH, a setting that contains a highly susceptible patient population. Widespread infection control lapses likely allowed continued transmission. Similar to the situation in other care settings, appropriate infection control and case cohorting may help prevent and control outbreaks of GAS infection in LTACHs.
C1 [Deutscher, Meredith; Van Beneden, Chris A.] Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Resp Dis Branch, Atlanta, GA USA.
   [Deutscher, Meredith; Schillie, Sarah] Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA.
   [Schillie, Sarah; Gould, Carolyn] Natl Ctr Emerging & Zoonot Infect Dis, Centers Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
   [Baumbach, Joan; Mueller, Mark; Avery, Catherine] New Mexico Dept Hlth, Albuquerque, NM USA.
C3 Centers for Disease Control & Prevention - USA; CDC National Center for
   Immunization & Respiratory Diseases (NCIRD); Centers for Disease Control
   & Prevention - USA; CDC Office of Workforce & Career Development (OWCD);
   Centers for Disease Control & Prevention - USA; New Mexico Department of
   Health
RP Van Beneden, CA (通讯作者)，Ctr Dis Control & Prevent, Resp Dis Branch, 1600 Clifton Rd,Mailstop C 23, Atlanta, GA 30333 USA.
EM cav7@cdc.gov
FU Respiratory Diseases Branch, Centers for Disease Control and Prevention,
   Atlanta, Georgia; New Mexico Department of Health
FX This work was supported by the Respiratory Diseases Branch, Centers for
   Disease Control and Prevention, Atlanta, Georgia and the New Mexico
   Department of Health.
CR [Anonymous], REPORT CTR HLTH DESI
   [Anonymous], 2003, MMWR MORB MORTAL WKL
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NR 18
TC 29
Z9 32
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD APR 15
PY 2011
VL 52
IS 8
BP 988
EP 994
DI 10.1093/cid/cir084
PG 7
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA 747DI
UT WOS:000289300100005
PM 21460311
OA Bronze
DA 2026-07-24
ER

PT J
AU Tedesco, S
   Di Grezia, M
   Altieri, G
   Cina, C
   Fico, V
   Misuriello, F
   Bracalente, G
   Piras, E
   Brisinda, G
AF Tedesco, Silvia
   Di Grezia, Marta
   Altieri, Gaia
   Cina, Caterina
   Fico, Valeria
   Misuriello, Filomena
   Bracalente, Giada
   Piras, Edoardo
   Brisinda, Giuseppe
TI Results of surgical treatment of necrotizing soft tissue infections. A
   15-years retrospective cohort study of a single center of emergency
   surgery
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Debridement; Humans; Necrosis; Soft Tissue Infections; Risk factors;
   Surgery
ID PRESSURE WOUND THERAPY; ACUTE PHYSIOLOGY; LIMB LOSS; SKIN; MANAGEMENT;
   MORTALITY; SCORE; CLASSIFICATION; PREDICTORS; GUIDELINES
AB Background Although rare, necrotizing soft tissue infections carries a high risk of mortality and morbidity. Extensive surgical debridement of necrotic tissues until healthy tissue is the cornerstone of management. Despite this, in-hospital mortality remains high for these patients. Methods We evaluated the experience of an Emergency Surgery center over a 15-year period. We evaluated factors related to in-hospital mortality. Secondary outcomes were assessment of morbidity, need for intensive care admission, risk of amputation, and outcomes related to the timing of surgery. Results One hundred and eight patients were included in this retrospective cohort study. All patients, except one (99.1%), underwent surgical debridement. Of these, 64 patients (59.3%) required multiple revisions (2.0 +/- 2.7). Negative pressure wound therapy was applied to 52 patients (48.1%), for a mean duration of 21.7 +/- 23.3 days. The mortality rate was 25.9% (28 patients). Ninety patients (83.3%) developed a complication during hospitalization, most of which were severe (20 patients grade III and 64 grade IV). Patients operated on within 10 h experienced a reduction in the rate of major complications (P = 0.02). Fourteen patients (13%) underwent limb amputation and 37 patients (34.3%) presented motor deficits at discharge. Conclusions Necrotizing soft tissue infections are a challenge for the emergency surgeon. An accurate diagnosis is not always possible and rapid intervention improves the results. Currently, there are no elements that allow a definitive diagnosis and a determining factor for a correct and accurate diagnostic framework is the competence of the surgeon.
C1 [Tedesco, Silvia; Di Grezia, Marta; Altieri, Gaia; Cina, Caterina; Fico, Valeria; Misuriello, Filomena; Bracalente, Giada; Piras, Edoardo; Brisinda, Giuseppe] IRCCS, Fdn Policlin Univ Gemelli, Emergency Surg & Trauma Ctr, I-00168 Rome, Italy.
   [Tedesco, Silvia] IRCCS, Fdn Policlin Univ Gemelli, Thorac Surg, I-00168 Rome, Italy.
   [Misuriello, Filomena; Bracalente, Giada; Piras, Edoardo; Brisinda, Giuseppe] Catholic Sch Med Agostino Gemelli, I-00168 Rome, Italy.
   [Brisinda, Giuseppe] IRCCS, Fdn Policlin Univ Gemelli, Dept Med & Surg Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Catholic University of the Sacred Heart
RP Brisinda, G (通讯作者)，IRCCS, Fdn Policlin Univ Gemelli, Emergency Surg & Trauma Ctr, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，Catholic Sch Med Agostino Gemelli, I-00168 Rome, Italy.; Brisinda, G (通讯作者)，IRCCS, Fdn Policlin Univ Gemelli, Dept Med & Surg Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM giuseppe.brisinda@policlinicogemelli.it
RI ; Brisinda, Giuseppe/G-6436-2010; Fico, Valeria/KUF-2684-2024
OI Piras, Edoardo/0009-0002-0967-1719; Bracalente,
   Giada/0009-0002-4596-2644; 
FU Universit Cattolica del Sacro Cuore
FX Open access funding provided by Universita Cattolica del Sacro Cuore
   within the CRUI-CARE Agreement.
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NR 64
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD MAR 31
PY 2026
VL 411
IS 1
AR 132
DI 10.1007/s00423-026-04038-x
EA MAR 2026
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HU0IM
UT WOS:001762674900001
PM 41915240
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Vijayan, D
   Hodgkinson, JD
   Li, E
   Pinkney, T
   Slade, D
AF Vijayan, Deepak
   Hodgkinson, Jonathan D.
   Li, Elizabeth
   Pinkney, Thomas
   Slade, Dominic
TI National Open Abdomen Audit (NOAA) - protocol for an observational audit
   of the use and management of the open abdomen in secondary care across
   Great Britain and Ireland
SO COLORECTAL DISEASE
LA English
DT Article
DE damage control laparotomy; fascial closure; intestinal failure;
   intestinal fistula; negative pressure wound therapy; open abdomen;
   peritonitis
AB Aim Use of open abdomen (OA) remains an important life-saving manoeuvre in the management of trauma and the abdominal catastrophe. The National Open Abdomen Audit (NOAA) is an audit project investigating the indications, management, and subsequent outcomes of OA treatment throughout the UK. The aim is to generate a snapshot of practice which will inform the management of future patients and potentially reduce the significant harm that can be associated with OA.Methods and analysis NOAA is a collaborative, prospective observational audit recruiting patients from across Great Britain and Ireland. The study will open from July 2023 with rolling recruitment across participating sites. All adult patients who leave theatre with an OA will be included and followed-up for 90 days. The primary objective is to prospectively audit the national variability in the management of the OA. Secondary outcomes include the treatment modality used for OA, indication, outcome of treatment and complications, including mortality and development of intestinal failure. All data will be recorded and managed using the secure REDCap electronic data capture and analysed using Stata (version 16.1). Results will be reported in accordance with the STROBE statement.Conclusion Results will be used to formulate a practical clinical guideline on when to implement an OA along with a stepwise management plan once initiated to reduce the associated morbidity and mortality. It is hoped that participation in this study will facilitate education of surgeons with a "trickle down" effect on all members of the surgical team and remove variability in the management.
C1 [Vijayan, Deepak; Li, Elizabeth] Univ Birmingham, BiCOPS, Birmingham Clin Trials, Publ Hlth Bldg, Birmingham, England.
   [Hodgkinson, Jonathan D.] Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Oxford, England.
   [Slade, Dominic] Salford Royal NHS Fdn Trust, Northern Care Alliance, Salford, England.
   [Slade, Dominic] Salford Royal NHS Fdn Trust, Stott Lane, Salford M6 8HD, England.
C3 University of Birmingham; University of Oxford; Oxford University
   Hospitals NHS Foundation Trust; Salford Royal NHS Foundation Trust;
   Salford Royal NHS Foundation Trust
RP Slade, D (通讯作者)，Salford Royal NHS Fdn Trust, Stott Lane, Salford M6 8HD, England.
EM dominic.slade@nca.nhs.uk
RI ; Slade, Dominic/AAE-8585-2022; Pinkney, Thomas/HGA-4022-2022; Li,
   Elizabeth/AFS-1376-2022
OI Li, Elizabeth/0000-0001-5961-2894; Slade, Dominic/0000-0002-6032-8580;
   Ahmed, Nauman/0000-0002-8976-3578; Pinkney, Thomas/0000-0001-7320-6673; 
FU Bowel Research UK; Birmingham Centre for Observational and Prospective
   Studies (BiCOPS); Salford Royal NHS Foundation Trust
FX This study has been funded by Bowel Research UK. The study will be
   coordinated via Birmingham Centre for Observational and Prospective
   Studies (BiCOPS) who will provide material and technological support.
   Participating centres will not bear any costs for being part of this
   audit. Similarly, no financial reimbursement will be made to units or
   investigators for their involvement. The sponsor for NOAA is the Salford
   Royal NHS Foundation Trust. Neither the funder nor the sponsor have had
   any input in the design of the study or data analysis
CR [Anonymous], National Emergency Laparotomy Audit (NELA) Project Team. Principle Standards Reported by the National Emergency Laparotomy Audit (NELA)
   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
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NR 9
TC 0
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2023
VL 25
IS 7
BP 1512
EP 1518
DI 10.1111/codi.16642
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA N0MD9
UT WOS:001034052300023
PM 37477409
DA 2026-07-24
ER

PT J
AU Marrano, E
   Bunino, F
   Del Zotto, G
   Ceolin, M
   Mei, S
   Brocchi, A
   Kurihara, H
AF Marrano, Enrico
   Bunino, Francesca
   Del Zotto, Giulio
   Ceolin, Martina
   Mei, Simona
   Brocchi, Andrea
   Kurihara, Hayato
TI Open abdomen: is a dedicated emergency surgery team needed? A single
   center retrospective study on 141 consecutive patients
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE acute care surgery; emergency general surgery; open abdomen; septic
   abdomen
ID MANAGEMENT
AB Background Open Abdomen (OA) is widely used when facing a catastrophic abdomen. Still, no indication is validated by a strong and high quality of evidence. The study reports the 5 year experience of a dedicated emergency general surgery (EGS) team. Methods Retrospective observational cohort study. Patients undergoing OA management from 2/01/2015 to 19/07/2020 for trauma, non-traumatic emergencies or rescue surgery. Results One hundred and forty-one patients. Age 66.9 +/- 15.1. Male 58.2%.9.3% OA for trauma, 64.5% for non-traumatic emergencies and 26.2% for rescue surgery. 40.4% performed by the EGS team 52.4% indication for surgery was a severe intra-abdominal infection. TAC device: commercial negative pressure wound therapy (NPWT) (83%), Sandwich VAC (12%), commercial NPWT with polypropylene mesh (5%) for pregressive fascial traction. Enteroatmospheric fistula (EAF) in 3 patients. OA duration 5.3 days (1-25). A 1.8 revision surgeries (0-12) required for definitive closure; ICU stay 9.9 days (0-78). 30-day mortality 23.5%. Overall and 1-year mortality were 47.5% and 43.3%. Overall survival 9.9 months. An increased one-year mortality rate was found in the >65 group (P = 0.01). Conclusions We reported a wide use of OA in septic abdomen (90% of cases). We had a low rate of EAF, short ICU stay and OA duration. These results are related to the fact that patients were treated by a dedicated EGS team, suggesting that OA management should be cared for as much as possible by trained and experienced surgeons. Prospective studies with more accurate patient selection are needed to prove our conclusions.
C1 [Marrano, Enrico; Bunino, Francesca; Del Zotto, Giulio; Ceolin, Martina; Mei, Simona; Brocchi, Andrea] IRCCS Humanitas Res Hosp, Dept Gen Surg, Emergency Surg & Trauma Sect, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
   [Kurihara, Hayato] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Emergency Surg Unit, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Marrano, E (通讯作者)，IRCCS Humanitas Res Hosp, Dept Gen Surg, Emergency Surg & Trauma Sect, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM dott.e.marrano@gmail.com
RI ; marrano, enrico/HTP-5057-2023; Brocchi, Andrea/PKG-9040-2026; Ceolin,
   Martina/HOF-2927-2023; Kurihara, Hayato/AAW-5550-2020
OI Brocchi, Anea/0000-0001-6707-8257; Bunino, Francesca
   Margherita/0000-0002-7600-9664; Del Zotto, Giulio/0000-0003-1346-8545;
   marrano, enrico/0000-0001-6818-0448; 
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NR 18
TC 3
Z9 6
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD SEP
PY 2022
VL 92
IS 9
BP 2213
EP 2217
DI 10.1111/ans.17949
EA JUL 2022
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 4M0GB
UT WOS:000832966800001
PM 35906883
DA 2026-07-24
ER

PT J
AU Witkowski, W
   Jawien, A
   Witkiewicz, W
   Zon, B
AF Witkowski, Wojciech
   Jawien, Arkadiusz
   Witkiewicz, Wojciech
   Zon, Bartlomiej
TI Initial multi-centre observations upon the effect of a new topical
   negative pressure device upon patient and clinician experience and the
   treatment of wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Topical negative pressure; TNP; Negative pressure wound therapy; NPWT;
   Wound management
AB Topical Negative Pressure (TNP) has become an accepted intervention in wound healing with a growing body of scientific literature supporting the effectiveness of TNP across a wide variety of wound aetiologies. The range of TNP devices has also increased with perhaps the primary distinction being between those TNP devices that employ gauze or foam as a wound dressing. This study reports preliminary multi-centre observations upon the use of a new gauze based TNP device in the treatment of wounds. Across 3 study centres twenty-nine subjects were recruited to the study with 8 presenting with leg ulcers, 8 with pressure ulcers, 12 with acute or surgical wounds and 1 with a non-healing burn injury. Wounds were then treated with the new TNP therapy for a maximum of 17 days (range 2-17 days). There appeared to be a trend for subjects with leg ulcers to be treated for longer (mean duration 12.9 days) compared to subjects with pressure ulcers (mean duration 6.5 days) or those with surgical wounds (mean duration 8.2 days). Given the relatively short duration of the TNP therapy no wound completely healed although 22/29 (75.9%) showed reductions in surface area per day of treatment with all but 1 pressure ulcer and 1 leg ulcer responding positively to treatment. While not an RCT, this and similar cohort studies may be central to the future selection of TNP devices given the increasing importance of the role of the user interface to reduce the likelihood of incorrect use and sub-optimal outcomes.
C1 [Witkowski, Wojciech; Zon, Bartlomiej] Mil Inst Hlth Serv, Plast Reconstruct Surg & Burn Management Dept, Warsaw, Poland.
   [Jawien, Arkadiusz] Reg Specialist Hosp, Bydgoszcz, Poland.
   [Witkiewicz, Wojciech] Reg Specialist Hosp, Wroclaw, Poland.
RP Witkowski, W (通讯作者)，Mil Inst Hlth Serv, Plast Reconstruct Surg & Burn Management Dept, Warsaw, Poland.
EM wojwit@wim.mil.pl
RI Jawien, Arkadiusz/L-1475-2014
OI Jawien, Arkadiusz/0000-0001-8380-9371
CR [Anonymous], BEDSORE BIOMECHANICS
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   CHARIKER M E, 1989, Contemporary Surgery, V34, P59
   CLARK M, 1996, P 6 EUR C ADV WOUND, P124
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Mendonca Derick A, 2006, Int Wound J, V3, P261, DOI 10.1111/j.1742-481X.2006.00266.x
   UBBINK DT, 2001, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD001898
   WITKOWSKI W, 2008, EWMA J S, V8, P47
NR 8
TC 11
Z9 23
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2009
VL 6
IS 2
BP 167
EP 174
DI 10.1111/j.1742-481X.2009.00586.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BT
UT WOS:000207845800011
PM 19432667
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Costa, ML
   Achten, J
   Parsons, NR
AF Costa, M. L.
   Achten, J.
   Parsons, N. R.
CA WOLLF collaborators
TI Five-year outcomes for patients sustaining severe fractures of the lower
   limb MID-TERM RESULTS FROM THE WOUND MANAGEMENT FOR OPEN LOWER LIMB
   FRACTURE (WOLLF) TRIAL
SO BONE & JOINT JOURNAL
LA English
DT Article
ID ADULTS; DISABILITY; INFECTION; THERAPY; EUROQOL
AB Aims
   The aim of this study was to report the outcomes of patients with severe open fractures of the lower limb in the five years after they took part in the Wound management for Open Lower Limb Fracture (WOLLF) trial.
   Methods
   The WOLLF trial compared standard dressings to negative pressure wound therapy (NPWT) applied at the end of the first surgical wound debridement, and patients were followed-up for 12 months. At 12 months, 170 of the original 460 participants agreed to take part in this medium-term follow-up study. Patients reported their Disability Rating Index (DRI) (0 to 100, where 100 is total disability) and health-related quality of life (HRQoL) using the EuroQol five-dimension three-level health questionnaire (EQ-5D-3L) annually by self-reported questionnaire. Further surgical interventions related to the open fracture were also recorded.
   Results
   There was no evidence of a difference in patient-reported disability, HROoL, or the need for further surgery between patients treated with NPWT versus standard dressings at five years. Considering the combined results for all participants, there was a small but statistically significant change in DRI scores over time (1.6 units per year; p = 0.005), but no evidence that EQ-5D-3L scores changed significantly during years two to five (p = 0.551).
   Conclusion
   This study shows that the high levels of disability and reduced HRQoL reported by patients 12 months after severe open fractures of the lower limb persist in the medium term, with little evidence of improvement between years two and five.
C1 [Costa, M. L.] Univ Oxford, Orthopaed Trauma Surg, Oxford, England.
   [Achten, J.] Univ Oxford, Oxford Trauma & Emergency Care, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England.
   [Parsons, N. R.] Univ Warwick, Warwick Med Sch, Clin Trials Unit, Coventry, W Midlands, England.
C3 University of Oxford; University of Oxford; University of Warwick
RP Costa, ML (通讯作者)，Univ Oxford, Orthopaed Trauma Surg, Oxford, England.
EM matthew.costa@ndorms.ox.ac.uk
RI ; Parsons, Nick/AAA-8713-2019; Achten, Juul/KUD-8515-2024
OI Costa, Matthew/0000-0003-3644-1388; Parsons, Nick/0000-0001-9975-888X;
   Achten, Juul/0000-0002-8857-5743
FU UK National Institute for Health Research (NIHR) Health Technology
   Assessment (HTA) programme [10/57/20]; NIHR HTA programme [HTA
   10/57/20]; NIHR Oxford Biomedical Research Centre; National Institutes
   of Health Research (NIHR) [HTA/10/57/20] Funding Source: National
   Institutes of Health Research (NIHR)
FX The authors disclose receipt of the following financial or material
   support for the research, authorship, and/or publication of this
   article: funding from the UK National Institute for Health Research
   (NIHR) Health Technology Assessment (HTA) programme (reference 10/57/20)
   . The original WOLLF trial was funded by the NIHR HTA programme (HTA
   10/57/20) and this five-year follow-up was supported by the NIHR Oxford
   Biomedical Research Centre. The funder has not been involved in the
   design and conduct of the study; collection, management, analysis, and
   interpretation of the data, the preparation, review, or approval of the
   manuscript, nor in the decision to submit the manuscript for
   publication. The views expressed are those of the authors and not
   necessarily those of the NHS, the NIHR or the Department of Health.
CR Bates D, 2015, J STAT SOFTW, V67, P1, DOI 10.18637/jss.v067.i01
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NR 16
TC 9
Z9 14
U1 0
U2 2
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD MAY
PY 2022
VL 104B
IS 5
BP 633
EP 639
DI 10.1302/0301-620X.104B5.BJJ-2021-1568.R2
PG 7
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 1H6ZV
UT WOS:000796690300009
PM 35491582
DA 2026-07-24
ER

PT J
AU Du, Y
   Han, S
   Zhou, Y
   Chen, HF
   Lu, YL
   Kong, ZY
   Li, WP
AF Du, Yao
   Han, Song
   Zhou, Yue
   Chen, Hai Feng
   Lu, Yao Liang
   Kong, Zhi Yuan
   Li, Wei Ping
TI Severe wound infection by MRCNS following bilateral inguinal
   herniorrhaphy
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE MRCNS; Wound infection; Hernia; Inguinal
ID SURGICAL SITE INFECTIONS; ANTIBIOTIC-PROPHYLAXIS; HERNIA; EPIDEMIOLOGY;
   PREVENTION; GUIDELINES
AB BackgroundWound infection after inguinal hernia surgery is not uncommon in the clinical setting. The common microbial aetiology of postoperative inguinal hernia wound infection is Gram-positive bacteria. Staphylococcus aureus is a common pathogen causing wound infection while Staphylococcus epidermidis and Pseudomonas are rare. Staphylococcus epidermidis as a cause of severe wound infection is rarely described in literature. We herein present a case of a 79-year-old man with a rare wound infection after bilateral inguinal herniorrhaphy caused by MRCNS (Methicillin Resistant Coagulase Negative Staphylococcus).Case presentationWe present a case of wound infection accompanied by fever with a temperature of 38.8 degrees C after bilateral inguinal herniorrhaphy in a 79-year-old man. Bilateral inguinal wounds were marked by redness and swelling, with skin necrosis. In addition, an abscess of approximately 1.5 cm x 1.5 cm was seen on the left wrist. A small amount of gas under the skin in the wound area was observed after pelvic computed tomography (CT) scans. No bacteria were cultured from the inguinal wound discharge, while blood culture detected MRCNS, and Acinetobacter lwoffi was cultured from the pus in the left wrist. We chose appropriate antibiotics based on the results of the bacterial culture and the drug susceptibility results. Vacuum assisted closure (VAC) therapy was used after debridement. The patient was discharged after the wounds improved. He was followed up for ten months and showed no signs of complications. We are sharing our experience along with literature review.ConclusionsWe are presenting a rare case of MRCNS wound infection following open inguinal hernia surgery. Although a rarity, clinicians performing inguinal hernia surgery must consider this entity in an infected wound and follow up the patient for complications of MRCNS.
C1 [Du, Yao; Han, Song; Zhou, Yue; Lu, Yao Liang; Kong, Zhi Yuan; Li, Wei Ping] Soochow Univ, Peoples Hosp Taicang City 1, Dept Gen Surg, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
   [Du, Yao] Nanchang Univ, Dept Gen Surg, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China.
   [Chen, Hai Feng] Soochow Univ, Peoples Hosp Taicang City 1, Dept Gastroenterol, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
C3 Soochow University - China; Nanchang University; Soochow University -
   China
RP Li, WP (通讯作者)，Soochow Univ, Peoples Hosp Taicang City 1, Dept Gen Surg, Taicang Affiliated Hosp, Taicang City 215400, Jiangsu, Peoples R China.
EM question12397@163.com
OI Li, Weiping/0000-0003-0729-4438
FU Suzhou Municipal Science and Technology Bureau [TC2021JCYL21] Funding
   Source: Medline
CR Breurec S, 2011, CLIN MICROBIOL INFEC, V17, P160, DOI 10.1111/j.1469-0691.2010.03219.x
   Cai LZ, 2018, SURG INFECT, V19, P11, DOI 10.1089/sur.2017.154
   Chen Leon L, 2020, Nursing, V50, P34, DOI 10.1097/01.NURSE.0000694752.85118.62
   Dohmen PM, 2008, J HOSP INFECT, V70, P15, DOI 10.1016/S0195-6701(08)60019-5
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   Mandell GL., 2010, PRINCIPLES PRACTICE, V7th
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   Ortega G, 2012, J SURG RES, V174, P33, DOI 10.1016/j.jss.2011.05.056
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NR 18
TC 1
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD FEB 7
PY 2023
VL 23
IS 1
AR 85
DI 10.1186/s12879-023-08039-9
PG 6
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 8T1XO
UT WOS:000929062200008
PM 36750769
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Turcotte, JJ
   Boord, A
   Antognoli, L
   Klune, JR
   Feather, CB
AF Turcotte, Justin J.
   Boord, Andrea
   Antognoli, Lauren
   Klune, J. Robert
   Feather, Cristina B.
TI Does Wound Management Technique Impact Surgical Site Infection in Open
   Emergency Colon Procedures?
SO AMERICAN SURGEON
LA English
DT Article
DE surgical site infection; wound closure; emergency colorectal surgery
ID COLORECTAL SURGERY; RISK-FACTORS; METAANALYSIS
AB Background Emergency open large bowel procedures have higher rates of intraoperative contamination and increased risk of surgical site infection (SSI) than elective colon surgeries. Several wound management strategies have been proposed, such as vacuum-assisted closure (VAC) therapy and delayed primary closure to improve results. The purpose of this study is to evaluate the relationship between wound management technique and SSI and other quality measures. Methods We performed a retrospective review of patients undergoing open emergency colon surgery from January 2017 to December 2018 by our acute care surgery service. The primary outcome measure was incidence of SSI. Secondary outcome measures included length of stay, reoperation, and 30-day readmission. Results A total of 118 patients were included in the study, with a mean age of 62.8 years and mean BMI of 28.8. Overall incidence of SSI was 19.5%. There was no significant difference in incidence of SSI, reoperation, or 30-day readmission when stratifying by wound management technique or procedure type after controlling for confounding variables. Notably, patients managed with VAC therapy had a statistically significant longer average length of stay and higher total postoperative antibiotic days (both P = .001) than other techniques. Discussion We conclude from our data that wound management technique does not seem to influence rate of SSI, but wound management may influence length of stay or antibiotic duration. These findings suggest that there may not be an advantage to alternative methods of wound management in this high-risk population. Further prospective evaluation should be performed to confirm these findings.
C1 [Turcotte, Justin J.; Boord, Andrea; Antognoli, Lauren; Klune, J. Robert; Feather, Cristina B.] Anne Arundel Med Ctr, Dept Surg, 2001 MED PKWY, Annapolis, MD 21401 USA.
RP Feather, CB (通讯作者)，Anne Arundel Med Ctr, Dept Surg, 2001 MED PKWY, Annapolis, MD 21401 USA.
EM cfeather@aahs.org
RI Feather, Cristina/AAA-3705-2022
OI Boord, Anea/0000-0002-8988-4054
CR Alkaaki A, 2019, CAN J SURG, V62, P111, DOI 10.1503/cjs.004818
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   Ejaz A, 2017, J SURG RES, V217, P153, DOI 10.1016/j.jss.2017.05.018
   Healthcare JCCfT, 2020, SURG SITE INFECT
   Hoang SC, 2019, AM J SURG, V217, P40, DOI 10.1016/j.amjsurg.2018.07.008
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   Watanabe M, 2014, SURG INFECT, V15, P256, DOI 10.1089/sur.2012.154
NR 13
TC 2
Z9 3
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JAN
PY 2022
VL 88
IS 1
BP 140
EP 145
DI 10.1177/0003134820982565
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XP2QO
UT WOS:000730715700020
PM 33382343
DA 2026-07-24
ER

PT J
AU Strangio, G
   Zullo, A
   Ferrara, EC
   Anderloni, A
   Carlino, A
   Jovani, M
   Ciscato, C
   Hassan, C
   Repici, A
AF Strangio, Giuseppe
   Zullo, Angelo
   Ferrara, Elisa Chiara
   Anderloni, Andrea
   Carlino, Alessandra
   Jovani, Manol
   Ciscato, Camilla
   Hassan, Cesare
   Repici, Alessandro
TI Endo-sponge therapy for management of anastomotic leakages after
   colorectal surgery: A case series and review of literature
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Article
DE Anastomotic leakage; Colon surgery; Endoscopic treatment; Endo-sponge
ID TOTAL MESORECTAL EXCISION; VACUUM-ASSISTED CLOSURE; RECTAL-CANCER;
   ANTERIOR RESECTION; RISK-FACTORS; DRAINAGE; LEAKS; EXPERIENCE; SINUSES;
   IMPACT
AB Background: Endo-sponge treatment is a novel approach to manage selected patients with anastomotic leakage following colorectal surgery. However, the available data are still scanty.
   Aims: To evaluate the efficacy and safety of the endo-sponge therapy in a large series, and to perform a review of the current evidence concerning such a treatment.
   Methods: Consecutive patients diagnosed with partial colonic anastomotic leakage managed with endo-sponge placement were enrolled. The endo-sponge system was changed every 48-72 h as outpatient, until to cavity closure. Literature review was performed for pooled-data analysis.
   Results: Twenty-five patients were enrolled, including 13 (52%) with diverting ileostomy. Following endo-sponge applications (median sessions: 9, range: 1-39; median treatment duration: 4 weeks, range: 1-32), a complete healing was achieved in 22 (88%) patients. Three (12%) patients developed a major complication (1 uretheric fistula, 1 ileal fistula, and 1 pararectal abscess), all successfully treated by surgery. Ileostomy closure was achieved in 11 (84.6%) patients. No mortality related to the procedure was observed. Overall, 174 patients treated with endo-sponge were reported in literature. By considering data of the larger 7 studies, a complete healing of presacral cavity was achieved in 131 (94.3%) out of 149 patients.
   Conclusions: Our relatively large series of patients confirmed the efficacy, tolerability, and an acceptably low complication rate of endo-sponge therapy for colorectal anastomosis leakage treatment. (C) 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Strangio, Giuseppe; Ferrara, Elisa Chiara; Anderloni, Andrea; Carlino, Alessandra; Jovani, Manol; Ciscato, Camilla; Repici, Alessandro] IRCCS Ist Clin Humanitas, Dept Gastroenterol, Milan, Italy.
   [Zullo, Angelo; Hassan, Cesare] Nuovo Regina Margherita Hosp, Gastronterol & Digest Endoscopy, Rome, Italy.
C3 Humanitas University; IRCCS Humanitas Research Hospital; Poliambulatorio
   Nuovo Regina Margherita
RP Zullo, A (通讯作者)，PTP Nuovo Regina Margherita, Gastroenterol Endoscopia Digest, Via E Morosini 30, I-00153 Rome, Italy.
EM angelozullo66@yahoo.it
RI hassan, cesare/H-2844-2012; Zullo, Angelo/AAV-7092-2020; Repici,
   Alessandro/HFH-8162-2022; Anderloni, Andrea/ABE-9139-2020
OI hassan, cesare/0000-0001-7167-1459; Zullo, Angelo/0000-0003-2329-8105;
   Repici, Alessandro/0000-0002-1621-6450; Anderloni,
   Andrea/0000-0002-1021-0031
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NR 33
TC 48
Z9 58
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD JUN
PY 2015
VL 47
IS 6
BP 465
EP 469
DI 10.1016/j.dld.2015.02.007
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CI6MY
UT WOS:000354875000007
PM 25769505
DA 2026-07-24
ER

PT J
AU Willy, C
   Voelker, HU
   Engelhardt, M
AF Willy, Christian
   Voelker, Hans-Ulrich
   Engelhardt, Michael
TI Literature on the subject of vacuum therapy: Review and update 2006
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE vacuum therapy; vacuum-assisted closure; peer-reviewed literature;
   evidence-based medicine
ID EVIDENCE-BASED MEDICINE; ASSISTED CLOSURE; WOUND CONTROL
AB Introduction: Today, vacuum therapy can be regarded as established in routine clinical use. Many hundreds of reports on the subject of vacuum therapy have appeared in medical literature. This review intends to give an overview of the peer-reviewed literature published to date and its quality considering criteria of evidence-based medicine (EbM).
   Methods: Literature search (MEDLINE, EMBASE, Cochrane, extensive manual search); up to May 31, 2006; evidence level: Classification of the Oxford Centre for Evidence-based Medicine.
   Results: Five hundred and fifty peer-reviewed citations were identified. Impressive jump in the annual publication rate is found from the year 2000 onwards; continuous broadening of the fields of indications; over 85% of all reports are case reports/series (only n = 27; EbM level < 4). To date, most of the publications are by authors from the United States, Germany, United Kingdom, Austria, the Netherlands, Switzerland, France, and Sweden. 7.5% of all peer-reviewed articles investigate scientific back grounds.
   Discussion: The clinical significance of this therapy is underlined by an obviously continuously marked extension of the range of indications in all surgical fields, and even in extreme ages of the patients. There is a considerable deficit of basic pathophysiological research and well-designed studies. This "deficiency," however, when judged against the quality of the general medical literature, does not point to the poor efficacy or low benefit of vacuum therapy but should rather be seen as a symptom of the clinical practitioner's problems in dealing with modern aspects of the theoretical background of EbM.
C1 [Willy, Christian; Engelhardt, Michael] German Mil Hosp Ulm, Dept Surg, D-89081 Ulm, Germany.
   [Voelker, Hans-Ulrich] Univ Wurzburg, Inst Pathol, Wurzburg, Germany.
C3 Ulm University; Military Hospital Ulm; University of Wurzburg
RP Willy, C (通讯作者)，German Mil Hosp Ulm, Dept Surg, Oberer Eselsberg 40, D-89081 Ulm, Germany.
EM PDDrmedChristianWilly@Bundeswehr.org
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NR 12
TC 11
Z9 14
U1 0
U2 1
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 1863-9933
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2007
VL 33
IS 1
BP 33
EP 39
DI 10.1007/s00068-007-6143-4
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 313HV
UT WOS:000256732600006
PM 26815972
DA 2026-07-24
ER

PT J
AU Castillo, IA
   Heiner, JA
   Meremikwu, RI
   Kellam, J
   Warner, SJ
AF Castillo, Isaac A.
   Heiner, Jacob A.
   Meremikwu, Ramzy I.
   Kellam, James
   Warner, Stephen J.
TI Where Are We in 2022? A Summary of 11,000 Open Tibia Fractures Over 4
   Decades
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE open tibia; infection; nonunion; delayed union; Gustilo-Anderson
   classification
ID SOFT-TISSUE MANAGEMENT; PRESSURE WOUND THERAPY; INVASIVE PLATE
   OSTEOSYNTHESIS; BONE MORPHOGENETIC PROTEIN-2; VACUUM-ASSISTED CLOSURE;
   EXTERNAL FIXATION; DISTAL TIBIA; SHAFT FRACTURES; DEEP INFECTION; FLAP
   COVERAGE
AB Objectives:To determine the infection and nonunion rates for open tibia fracture treatment over the past 4 decades since the introduction of the Gustilo-Anderson (GA) open fracture classification.Data Sources:PubMed, Scopus, CINAHL, and Cochrane databases were reviewed using the PRISMA checklist for articles between 1977 and September 2018.Study Selection:One hundred sixty-one articles meeting the following inclusion criteria: English language, published between 1977 and 2018, reported infection rates, reported nonunion rates, and fractures classified by the GA open fracture criteria were selected.Data Extraction:All articles were thoroughly evaluated to extract infection and nonunion data for open tibia fractures.Data Synthesis:Due to variability in the data reviewed, statistical evaluation could not be reliably done.Results:11,326 open tibia fractures were reported with 17% type I, 25.2% type II, 25.3% type IIIA, and 32.5% type IIIB/C. The average infection rate over 4 decades was 18.3%, with 24.3% superficial, 11.2% deep, and 14.7% pin tract. The infection rate by decade was 14% for 1977-1986, 16.2% for 1987-1996, 20.5% for 1997%-2006%, and 18.1% from 2007 to 2017. The overall nonunion rate was 14.1%. The nonunion rate was 13% for 1977-1986, 17% for 1987-1996, 12.8% for 1997%-2006%, and 12.3% for 2007-2017.Conclusions:This in-depth summary has demonstrated that the percentage rate for infections and nonunion has remained similar over the past 40 years.
C1 [Castillo, Isaac A.] Univ Texas Med Branch, Dept Orthopaed Surg & Rehabil, Galveston, TX 77555 USA.
   [Heiner, Jacob A.; Kellam, James; Warner, Stephen J.] Univ Texas Hlth Sci Ctr Houston, Dept Orthoped Surg, Houston, TX USA.
   [Meremikwu, Ramzy I.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Health
   Science Center Houston; University of Michigan System; University of
   Michigan
RP Castillo, IA (通讯作者)，Univ Texas Med Branch, Dept Orthopaed Surg & Rehabil, Galveston, TX 77555 USA.
EM iscastil@utmb.ed
OI Heiner, Jacob/0000-0002-6749-723X
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   Yokoyama K, 2007, J TRAUMA, V63, P108, DOI 10.1097/TA.0b013e318074eacc
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   Yusof NM, 2013, MALAYS J MED SCI, V20, P47
   Ziran BH, 2004, INT ORTHOP, V28, P235, DOI 10.1007/s00264-004-0567-9
NR 168
TC 14
Z9 18
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD AUG
PY 2023
VL 37
IS 8
BP E326
EP E334
DI 10.1097/BOT.0000000000002602
PG 9
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA M3ZZ4
UT WOS:001029620800005
PM 36952593
DA 2026-07-24
ER

PT J
AU Gardenbroek, TJ
   Musters, GD
   Buskens, CJ
   Ponsioen, CY
   D'Haens, GRAM
   Dijkgraaf, MGW
   Tanis, PJ
   Bemelman, WA
AF Gardenbroek, T. J.
   Musters, G. D.
   Buskens, C. J.
   Ponsioen, C. Y.
   D'Haens, G. R. A. M.
   Dijkgraaf, M. G. W.
   Tanis, P. J.
   Bemelman, W. A.
TI Early reconstruction of the leaking ileal pouch-anal anastomosis: a
   novel solution to an old problem
SO COLORECTAL DISEASE
LA English
DT Article
DE Ileal pouch-anal anastomosis; inflammatory bowel disease; anastomotic
   leakage; vacuum assisted therapy; Endo-sponge (R)
ID VACUUM-ASSISTED CLOSURE
AB AimThe study aimed to determine the effectiveness and direct medical costs of early surgical closure of the anastomotic defect after a short course of Endo-sponge (R) therapy of the presacral cavity, compared with conventional treatment in patients with anastomotic leakage after ileal pouch-anal anastomosis (IPAA).
   MethodPatients with anastomotic leakage after IPAA undergoing early surgical closure of the anastomotic defect after a short Endo-sponge (R) treatment were prospectively followed and compared with a consecutive cohort of patients with an anastomotic leak treated by creation of a loop ileostomy and occasional drainage of the presacral cavity.
   ResultsA total of 15 patients were treated with early surgical closure and 29 were treated conventionally. In the early surgical closure group, the Endo-sponge (R) treatment was continued for a median of 12days [interquartile range (IQR) 7-15days] with a median of 3 (IQR 2-4) Endo-sponge (R) changes. Secondary anastomotic healing was achieved in all patients (n=15) in the early surgical closure group compared with 52% (n=16) in the conventional treatment group (P=0.003). Closure of the anastomotic defect was achieved after a median of 48 (25-103)days in the early surgical closure group compared with 70 (IQR 49-175)days in the conventional treatment group (P=0.013). A functional pouch was seen in 93% and 86% of the patients in each group. There was no significant difference in direct medical cost.
   ConclusionEarly surgical closure after a short period of Endo-sponge (R) treatment is highly effective in treating anastomotic leakage after IPAA without increasing cost.
C1 [Gardenbroek, T. J.; Musters, G. D.; Buskens, C. J.; Tanis, P. J.; Bemelman, W. A.] Acad Med Ctr, Dept Surg, NL-1100 DD Amsterdam, Netherlands.
   [Gardenbroek, T. J.] Onze Lieve Vrouw Hosp, Dept Surg, Amsterdam, Netherlands.
   [Ponsioen, C. Y.; D'Haens, G. R. A. M.] Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1100 DD Amsterdam, Netherlands.
   [Dijkgraaf, M. G. W.] Acad Med Ctr, Clin Res Unit, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Onze Lieve
   Vrouwe Gasthuis Hospital; University of Amsterdam; Academic Medical
   Center Amsterdam; University of Amsterdam; Academic Medical Center
   Amsterdam
RP Bemelman, WA (通讯作者)，Acad Med Ctr, Dept Surg, POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM w.a.bemelman@amc.uva.nl
RI Bemelman, Wilhelmus/AAA-1635-2021; Dijkgraaf, Marcel/G-6663-2011; Tanis,
   Pieter/U-2827-2019
OI Tanis, Pieter/0000-0002-3146-3310
CR Breen EM, 1998, DIS COLON RECTUM, V41, P691, DOI 10.1007/BF02236254
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NR 15
TC 51
Z9 53
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAY
PY 2015
VL 17
IS 5
BP 426
EP 432
DI 10.1111/codi.12867
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA CG8NO
UT WOS:000353565100016
PM 25512241
OA Green Accepted, Bronze
DA 2026-07-24
ER

PT J
AU Lee, KT
   Pyon, JK
   Lim, SY
   Mun, GH
   Oh, KS
   Bang, SI
AF Lee, Kyeong-Tae
   Pyon, Jai-Kyong
   Lim, So-Young
   Mun, Goo-Hyun
   Oh, Kap Sung
   Bang, Sa-Ik
TI Negative-pressure wound dressings to secure split-thickness skin grafts
   in the perineum
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative-pressure dressing; Perineum; Split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; MANAGEMENT; THERAPY;
   DEVICE; TRIAL; BED
AB Several researches have shown that negative-pressure wound dressings can secure split-thickness skin grafts and improve graft survival. However, in anatomically difficult body regions such as the perineum it is questionable whether these dressings have similar beneficial effects. In this study, we evaluated the effects of negative-pressure wound dressings on split-thickness skin grafts in the perineum by comparing wound healing rate and complication rate with that of tie-over dressings. A retrospective chart review was performed for the patients who underwent a split-thickness skin graft to reconstruct perineal skin defects between January 2007 and December 2011. After grafting, the surgeon selected patients to receive either a negative-pressure dressing or a tie-over dressing. In both groups, the initial dressing was left unchanged for 5 days, then changed to conventional wet gauze dressing. Graft success was assessed 2 weeks after surgery by a single clinician. A total of 26 patients were included in this study. The mean age was 56.6 years and the mean wound size was 273.1 cm(2). Among them 14 received negative-pressure dressings and 12 received tie-over dressings. Negative-pressure dressing group had higher graft taken rate (P = 0.036) and took shorter time to complete healing (P = 0.01) than tie-over dressing group. The patients with negative-pressure dressings had a higher rate of graft success and shorter time to complete healing, which has statistical significance. Negative-pressure wound dressing can be a good option for effective management of skin grafts in the perineum.
C1 [Lee, Kyeong-Tae; Pyon, Jai-Kyong; Lim, So-Young; Mun, Goo-Hyun; Oh, Kap Sung; Bang, Sa-Ik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Bang, SI (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Plast Surg, Ilwon Dong 50, Seoul 135710, South Korea.
EM skymaker26@gmail.com
RI Lee, Kyeong-Tae/AAJ-2478-2021; Mun, Goo-Hyun/I-2540-2019
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NR 17
TC 18
Z9 25
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2014
VL 11
IS 2
BP 223
EP 227
DI 10.1111/j.1742-481X.2012.01078.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AD7EF
UT WOS:000333424100017
PM 22958590
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Riss, S
   Stift, A
   Meier, M
   Haiden, E
   Grünberger, T
   Bergmann, M
AF Riss, S.
   Stift, A.
   Meier, M.
   Haiden, E.
   Gruenberger, T.
   Bergmann, M.
TI Endo-sponge assisted treatment of anastomotic leakage following
   colorectal surgery
SO COLORECTAL DISEASE
LA English
DT Article
DE Rectal surgery; anastomotic leakage; endo-sponge; vacuum assisted
   closure
AB Aim Endo-sponge assisted treatment (endo-sponge) represents a novel approach to treat patients with anastomotic dehiscence following anterior resection for rectal cancer. Yet, limited data are available to predict success, compatibility with radiotherapy and/or chemotherapy as well as acceptance by the patients.
   Method Between September 2007 and June 2008, nine patients suffering from anastomotic leakage after anterior rectal resection (n = 6) or suffering from leakage of rectal stump following Hartmann's procedure (n = 3) were treated by endo-sponge. We recorded clinical outcome and patient's comfort using a 10-point visual analogue scale (VAS).
   Results Median time of endo-sponge treatment was 3 weeks (range: 2-8). There were no minor or major complications. In 6 (66.6%) patients, the anastomotic leakage healed successfully. Three patients showed no response and needed further surgical intervention. The lack of success was due to complexity of the leakages, which comprised either more than 270 degrees of the circumference or consisted of two distant fistulas. Formation of granulation tissue was unaffected by chemotherapy. For the question 'alteration in daily life activity', a median score of 5 (range: 1-9) was found. Measuring 'pain sensation' during endo-sponge treatment patients scored a median of 3 (range: 0-6).
   Conclusions Endo-sponge treatment can be recommended as an alternative approach to treat pelvic sepsis following anastomotic dehiscence or rectal stump insufficiency. Extended leakages should be treated by different approaches having little probability of successful healing, but can lead to discomfort for the patient. Radiochemotherapy does not cause a problem for application of the endo-sponge.
C1 [Bergmann, M.] Med Univ Vienna, Dept Surg, Div Gen Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna
RP Bergmann, M (通讯作者)，Med Univ Vienna, Dept Surg, Div Gen Surg, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM michael.bergmann@meduniwien.ac.at
RI Gruenberger, Thomas/ABA-1661-2020; Bergmann, Michael/GZK-7700-2022
OI Gruenberger, Thomas/0000-0002-2671-0540; Stift,
   Anton/0000-0002-7243-8138; Bergmann, Michael/0000-0001-8529-1166
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NR 18
TC 35
Z9 41
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JUL
PY 2010
VL 12
IS 7
BP E104
EP E108
DI 10.1111/j.1463-1318.2009.01885.x
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA V23PY
UT WOS:000208355900016
PM 19508536
DA 2026-07-24
ER

PT J
AU Stojadinovic, A
   Elster, EA
   Anam, K
   Tadaki, D
   Amare, M
   Zins, S
   Davis, TA
AF Stojadinovic, Alexander
   Elster, Eric A.
   Anam, Khairul
   Tadaki, Douglas
   Amare, Mihret
   Zins, Stephen
   Davis, Thomas A.
TI Angiogenic response to extracorporeal shock wave treatment in murine
   skin isografts
SO ANGIOGENESIS
LA English
DT Article
DE Angiogenesis; Extracorporeal shock wave therapy; Skin graft; Wound
   healing
ID ENDOTHELIAL PROGENITOR CELLS; VACUUM-ASSISTED CLOSURE;
   GROWTH-FACTOR-BETA; FLAP SURVIVAL; GENE-THERAPY; BONE-MARROW;
   ELECTRICAL-STIMULATION; ISCHEMIC NECROSIS; MODEL; ULTRASOUND
AB Skin grafts are commonly utilized and proven effective methods of open wound coverage. Revascularization through neoangiogenesis is a pivotal mechanism for skin graft integration and durability. Extracorporeal shock-wave treatment (ESWT) has been demonstrated to accelerate wound repair; however, its mechanism-of-action is unclear. We investigated the role of ESWT in early revascularization of full-thickness skin isografts in a murine model. Cohorts of mice were euthanized and skin grafts were harvested 6 h, 2, 4, and 7 days post grafting +/- A ESWT. Various aspects of graft neovascularization were measured including gross morphology, quantitative microscopy (vessel number, density), immunohistochemistry (CD31), cDNA SuperArrays for 84 angiogenesis-specific genes, and custom-designed 'Wound Repair' TaqMan(A (R)) Low Density Array (TLDA) cards to assess expression of 188 wound repair genes. We demonstrate that a single administration of ESWT immediately following skin grafting significantly enhances recipient graft revascularization (increased vessel number, size, and density). An augmented early pro-angiogenic and suppressed delayed pro-inflammatory response to ESWT was accompanied by significantly increased expression of both skin graft CD31 and angiogenesis pathway-specific genes, including ELR-CXC chemokines (CXCL1, CXCL2, CXCL5), CC chemokines (CCL2, CCL3, CCL4), cytokines (IL-1 beta, IL-6, G-CSF, VEGF-A), matrix metalloproteinases (MMP3, MMP9, MMP13), hypoxia-inducible factors (HIF-1 alpha), and vascular remodeling kinase (Mst1), as early as 6 h and up to 7 days post grafting and treatment. These findings suggest that early pro-angiogenic and anti-inflammatory effects of ESWT promote tissue revascularization and wound healing by augmenting angiogenesis and dampening inflammation.
C1 [Elster, Eric A.; Anam, Khairul; Tadaki, Douglas; Amare, Mihret; Zins, Stephen; Davis, Thomas A.] USN, Regenerat Med Dept, Med Res Ctr, Silver Spring, MD 20910 USA.
   [Elster, Eric A.] Natl Naval Med Ctr, Combat Wound Initiat Program, Dept Surg, Bethesda, MD USA.
   [Stojadinovic, Alexander; Davis, Thomas A.] Walter Reed Army Med Ctr, Dept Surg, Combat Wound Initiat Program, Washington, DC 20307 USA.
   [Stojadinovic, Alexander; Elster, Eric A.; Tadaki, Douglas] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
C3 United States Department of Defense; United States Navy; Walter Reed
   National Military Medical Center; United States Department of Defense;
   United States Army; Walter Reed National Military Medical Center;
   Uniformed Services University of the Health Sciences - USA
RP Davis, TA (通讯作者)，USN, Regenerat Med Dept, Med Res Ctr, Room 2A10,503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM thomas.davis1@med.navy.mil
RI ; Elster, Eric/G-2332-2010
OI Stojadinovic, Alexander/0000-0002-2829-8967; Elster,
   Eric/0000-0002-0981-2748
FU ONR [602236N.42237, W160.A0806]; Henry M. Jackson Foundation
FX This work was supported by ONR work unit 602236N.42237. W160.A0806 and
   by the Combat Wound Initiative Program, a Congressionally funded program
   of the Henry M. Jackson Foundation for the Advancement of Military
   Medicine.
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NR 54
TC 97
Z9 106
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0969-6970
EI 1573-7209
J9 ANGIOGENESIS
JI Angiogenesis
PD DEC
PY 2008
VL 11
IS 4
BP 369
EP 380
DI 10.1007/s10456-008-9120-6
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 392NP
UT WOS:000262309700006
PM 18998221
DA 2026-07-24
ER

PT J
AU Izadi, K
   Ganchi, P
AF Izadi, K
   Ganchi, P
TI Chronic wounds
SO CLINICS IN PLASTIC SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CHRONIC VENOUS
   INSUFFICIENCY; HYPERBARIC-OXYGEN THERAPY; PARTIAL-THICKNESS BURNS;
   BACTERIAL BIOFILMS; CIGARETTE-SMOKING; RANDOMIZED-TRIAL;
   POVIDONE-IODINE; PRESSURE ULCERS
AB The definition of a chronic wound is not clearly outlined in the literature. Chronic wounds develop when there is a disruption in the normal healing process. They fail to heal within a "normal" period of time when similar wounds would otherwise have healed. Wounds that have failed to progress through a normal sequence of repair in 4 to 8 weeks are generally presumed to be chronic. Chronic wounds can be a challenge to the patient, the health care professional, and the health care system. Venous leg ulcers, pressure sores, ischemic ulcers, and diabetic foot ulcers are examples of chronic wounds. There are over 4 million Americans afflicted with these types of wounds, with an annual treatment cost of 9 billion dollars. A large percentage of these wounds occur in the growing elderly population. This becomes a large burden to society because of the loss of productivity and escalating health care costs [1]. Many factors can impair wound healing. Some of the local or intrinsic factors that impair wound healing include foreign bodies, tissue maceration, ischemia, and infection [2]. Medical disorders that are known to negatively affect wound healing include malnutrition, diabetes, and renal disease [2]. The pathophysiology of chronic wounds is not fully understood, and this incomplete understanding of the process results in many treatment failures. The ideal healing environment can be easily disrupted. This article describes the many processes that may inhibit or retard wound healing and some of the ways that the clinician may alter those processes to optimize healing. To facilitate healing, clinicians must be current on the physiology of wound healing and have in their armamentarium all the accepted and proven technologies that are available.
C1 Univ Med & Dent New Jersey, Dept Surg, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Izadi, K (通讯作者)，Univ Med & Dent New Jersey, Dept Surg, Div Plast Surg, 90 Bergen St, Newark, NJ 07103 USA.
EM Kiny10032@aol.com
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NR 103
TC 88
Z9 109
U1 1
U2 42
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-1298
EI 1558-0504
J9 CLIN PLAST SURG
JI Clin. Plast. Surg.
PD APR
PY 2005
VL 32
IS 2
BP 209
EP +
DI 10.1016/j.cps.2004.11.011
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 922FT
UT WOS:000228822600008
PM 15814118
DA 2026-07-24
ER

PT J
AU Montoya, AM
   Roncancio, GE
   Franco, L
   López, L
   Vargas, AR
   Suárez, S
   Garcés, CG
   Guzmán, M
   Vanegas, JM
AF Montoya, A. M.
   Roncancio, G. E.
   Franco, L.
   Lopez, L.
   Vargas, A. R.
   Suarez, S.
   Garces, C. G.
   Guzman, M.
   Vanegas, J. M.
TI Preventive strategies in paediatric cardiovascular surgery: impact on
   surgical site infections and beyond
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Article
DE Healthcare-associated infection prevention; Cardiovascular surgery;
   Congenital heart diseases; Microbiology
ID VENTILATOR-ASSOCIATED PNEUMONIA; CARE HOSPITALS; TIME
AB Background: Surgical management of congenital heart disease (CHD) has increased worldwide, but healthcare-associated infections (HAIs) can threaten these efforts. Aim: To analyse the incidence of HAI, the impact of preventive interventions, and microbiological profiles in a paediatric cardiovascular surgery programme.<br /> Methods: Cohort study including children aged < 12 years with CHD who underwent cardiovascular surgery between 2010 and 2021 in Medell & imath;<acute accent>n, Colombia (a middle-income setting). Data were collected from medical and laboratory records and infection control programme databases. Impact of various preventive interventions was assessed using a Poisson model. P < 0.05 was considered statistically significant. Findings: A total of 2512 surgeries were analysed. Incidence of surgical site infection (SSI) was 5.9%, followed by central line-associated bloodstream infection (CLABSI; 4.7%), catheter-associated urinary tract infection (CAUTI; 2.2%), and ventilator-associated pneumonia (VAP; 1.4%). Most of the strategies focused on preventing SSI, resulting in a reduction from 9.5% in 2010 to 3.0% in 2021 (P P 1 / 4 0.030). Antibiotic prophylaxis based on patient weight and continuous infusion had an impact on reducing SSI (RR: 0.56; 95% CI: 0.32-0.99). Vacuum-assisted closure (VAC) in clean wounds reduced 100% of infections. No significant risk reduction was observed for other HAI with the implemented interventions. Conclusion: Preventive strategies effectively reduced SSI but no other infections, emphasizing the need for targeted approaches to address a broader spectrum of HAI successfully. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Montoya, A. M.; Franco, L.] Clin Cardio VID, Dept Microbiol, Medellin, Colombia.
   [Roncancio, G. E.] Clin Cardio VID, Div Infect Dis, Medellin, Colombia.
   [Lopez, L.; Vargas, A. R.; Vanegas, J. M.] Univ Pontificia Bolivariana, Sch Hlth Sci, St 1A,70-01, Medellin, Colombia.
   [Suarez, S.] Clin Cardio VID, Dept Epidemiol, Medellin, Colombia.
   [Garces, C. G.] Clin Cardio VID, Dept Cardiovasc Surg, Medellin, Colombia.
   [Vanegas, J. M.] Clin Cardio VID, Dept Paediat, Medellin, Colombia.
C3 Universidad Pontificia Bolivariana
RP Vanegas, JM (通讯作者)，Univ Pontificia Bolivariana, Sch Hlth Sci, St 1A,70-01, Medellin, Colombia.
EM johanna.vanegas@upb.edu.co
RI ; Roncancio, Gustavo/E-7793-2017
OI Vanegas, Johanna/0000-0003-0649-6660; López López,
   Lucelly/0000-0002-1534-520X; 
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NR 52
TC 2
Z9 2
U1 0
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD AUG
PY 2024
VL 150
BP 114
EP 124
DI 10.1016/j.jhin.2024.05.001
EA JUL 2024
PG 11
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA YG4F6
UT WOS:001267315100001
PM 38740302
OA Bronze
DA 2026-07-24
ER

PT J
AU VanDolah, HB
   Li, KR
   Kim, KG
   Berger, LE
   Tefera, EA
   Acuna, KA
   Attinger, CE
   Fan, KL
   Evans, KK
AF VanDolah, Hunter B.
   Li, Karen R.
   Kim, Kevin G.
   Berger, Lauren E.
   Tefera, Eshetu A.
   Acuna, Kelly A.
   Attinger, Christopher E.
   Fan, Kenneth L.
   Evans, Karen K.
TI Positive Bacterial Cultures on Spinal Wound Closure Do Not Predict
   Postoperative Outcomes
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE wound infection; surgical wound infection; postoperative care; soft
   tissue infections; surgical wound dehiscence; surgical flaps
ID RISK-FACTORS; MANAGEMENT; INFECTIONS; RECONSTRUCTION; SURGERY; FUSION;
   COST
AB BackgroundComplex surgical back wounds represent significant morbidity in patients who have undergone spinal procedures requiring closure or revision by plastic surgeons. This study aimed to assess the utility of bacterial wound culture data for predicting surgical outcomes of wound management.MethodsThis study is a single-institution retrospective review of consecutive patients who required plastic surgery intervention for wound infection following spinal procedures between the years 2010 and 2021 (n = 70). Statistical analysis was performed for demographics, comorbidities, perioperative laboratory studies, and treatment methods. The primary outcomes of interest were rate of postoperative complications after soft tissue reconstruction and reconstructive failure. The secondary outcome of interest was time to healing in number of days.ResultsThe overall complication rate after wound closure was 31.4%, with wound infection in 12.9%, seroma in 10%, dehiscence in 12.9%, and hematoma in 1.4%. Increasing number of debridements before wound closure increased the likelihood of a surgical complication of any kind (odds ratio [OR], 1.772; 95% confidence interval [CI], 1.045-3.002). Positive wound cultures before reconstruction were associated with development of seroma only (OR, 0.265; 95% CI, 0.078-0.893). Use of incisional vacuum-assisted closure devices significantly decreased the odds of postoperative wound dehiscence (OR, 0.179; 95% CI, 0.034-0.904) and increased odds of healing (hazard ratio, 3.638; 95% CI, 1.547-8.613).ConclusionsPositive wound cultures were not significantly associated with negative outcomes after complex closure or reconstruction of infected spinal surgical wounds. This finding emphasizes the importance of clinical judgment with a multidisciplinary approach to complex surgical back wounds over culture data for wound closure timing.
C1 [VanDolah, Hunter B.; Li, Karen R.; Acuna, Kelly A.] Georgetown Univ, Sch Med, Washington, DC USA.
   [Kim, Kevin G.; Berger, Lauren E.; Attinger, Christopher E.; Fan, Kenneth L.; Evans, Karen K.] MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
   [Tefera, Eshetu A.] MedStar Hlth Res Inst, Dept Biostat & Biomed Informat, Hyattsville, MD USA.
   [Evans, Karen K.] Ctr Wound Healing & Hyperbar Med, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University; MedStar Health Research
   Institute
RP Evans, KK (通讯作者)，MedStar Georgetown Univ Hosp, Dept Plast & Reconstruct Surg, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.; Evans, KK (通讯作者)，Ctr Wound Healing & Hyperbar Med, 1st Floor,Bles Bldg,3800 Reservoir Rd Northwest, Washington, DC 20007 USA.
EM hbv5@georgetown.edu; krl67@georgetown.edu; kevin.kim@nyulangone.org;
   lb557@rwjms.rutgers.edu; eshetu.tefera@medstar.net;
   ka798@georgetown.edu; christopher.attinger@medstar.net;
   kf293@georgetown.edu; Karen.K.Evans@gunet.georgetown.edu
OI VanDolah, Hunter/0000-0003-4302-5729
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
   Atkinson RA, 2017, J HOSP INFECT, V95, P148, DOI 10.1016/j.jhin.2016.11.016
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NR 28
TC 0
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2024
VL 92
IS 5
BP 569
EP 574
DI 10.1097/SAP.0000000000003883
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TG5Q8
UT WOS:001240130600001
PM 38685496
DA 2026-07-24
ER

PT J
AU Blume, P
   Wu, S
AF Blume, Peter
   Wu, Stephanie
TI Updating the Diabetic Foot Treatment Algorithm: Recommendations on
   Treatment Using Advanced Medicine and Therapies
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic foot ulcers; diabetes; chronic wounds; wound care; wound
   management
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; CLASSIFICATION-SYSTEM;
   ROBUST PREDICTOR; 4-WEEK PERIOD; ULCERS; MANAGEMENT; CARE; MULTICENTER;
   MATRIX
AB Objective. Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment. Materials and Methods. A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library. Diabetic foot ulcer treatment algorithms were reviewed and changes recommended based on current standards of care, new treatment modalities, and clinical experience. Results. A multidisciplinary approach is recommended to address potential underlying problems. A visual inspection, foot pulse palpation, skin temperature measurement, and shoe gear, gait, orthopedic, neurologic, and vascular exams are recommended. Appropriate offloading and continuing diabetes education are included as treatment for all DFUs. If calluses or increased foot pressure are present, preventative care is necessary to prevent further tissue breakdown. If infection is present, treatment should follow the Infectious Diseases Society of America diabetic foot infection guidelines. As the DFU severity increases, advanced wound dressings and advanced wound therapies should be employed. In acute/chronic and acute/urgent DFUs, debridement, amputation, and skin grafting may be required. Conclusions. Treatment for DFUs should start when a possible pre-ulcer is noticed. This prophylactic treatment may reduce development of more severe DFUs. Once a DFU has developed, care should be optimized for both the patient and the wound bed. While these treatment recommendations are focused solely on DFUs, they may be expanded for use in other foot/leg pressure ulcers.
C1 [Blume, Peter] Yale Univ, Sch Med, Anesthesia & Orthoped & Rehabil, 800 Howard Ave, New Haven, CT 06519 USA.
   [Wu, Stephanie] Rosalind Franklin Univ Med & Sci, Dr William M Sch Coll Podiat Med, CLEAR, N Chicago, IL USA.
C3 Yale University; Rosalind Franklin University of Medicine & Science
RP Blume, P (通讯作者)，Yale Univ, Sch Med, Anesthesia & Orthoped & Rehabil, 800 Howard Ave, New Haven, CT 06519 USA.
EM peterb@ctfootandanklesurgery.com
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NR 47
TC 0
Z9 0
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2017
VL 29
IS 10
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FV2BR
UT WOS:000424369500003
DA 2026-07-24
ER

PT J
AU Willy, C
   Rieger, H
   Stichling, M
AF Willy, Christian
   Rieger, Hayo
   Stichling, Marcus
TI Prevention of postoperative infections. Risk factors and the current WHO
   guidelines in musculoskeletal surgery
SO UNFALLCHIRURG
LA German
DT Article
DE Infection rates; postoperative; Open fractures; Antibiotic prophylaxis;
   Infection pathogens; Infection avoidance
ID SURGICAL-SITE INFECTION; VACUUM-ASSISTED CLOSURE; TOTAL KNEE
   ARTHROPLASTY; PRESSURE WOUND THERAPY; PERIPROSTHETIC JOINT INFECTION;
   SEVERE OPEN FRACTURES; STAPHYLOCOCCUS-AUREUS; TOTAL HIP;
   ANTIBIOTIC-PROPHYLAXIS; METHICILLIN-RESISTANT
AB Background. Despite the many scientific and technological advances postoperative infection continues to be a large problem for trauma and orthopedic surgeons. Based on a review of the current literature, this study provides a comprehensive overview of the risk factors (RF) and possible preventive measures to control surgical site infections.
   Methods. Medline search and analysis from 1968-2017 (as of 01 March 2017). Selection of trauma and orthopedic relevant RFs and comparison with WHO recommendations (global guidelines for the prevention of surgical site infection, Nov. 2016).
   Results. Identification of 858 relevant articles from the last 50 years (1968-2017). Pooled postoperative rate of infection is 0.3% (hand surgery) and 19% (3rd degree open fractures). For open fractures, there is no clear tendency towards lower infection rates during the past five decades. Identification of 115 RF from three areas (patient-dependent RF, organizational and procedural RF, trauma- and surgery-dependent RF). The five most important RFs are body mass index over 35 kg/m(2), increased duration of surgery, diabetes mellitus, increased blood glucose levels in the perioperative period also in the case of nondiabetic patients, and errors in the perioperative antibiotic prophylaxis. Discussion. Inconsistent definition of "infection", interaction of the RF and the different follow-up duration limit the meaningfulness of the study.
   Conclusion. In the future, considerable efforts must be made in order to achieve a noticeable reduction in the rate of infection, especially in the case of high-risk patients.
C1 [Willy, Christian; Rieger, Hayo; Stichling, Marcus] Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg, Orthopedie,Sept Rekonstrukt Chirurg, Forschungs & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
RP Willy, C (通讯作者)，Bundeswehrkrankenhaus Berlin, Klin Unfallchirurg, Orthopedie,Sept Rekonstrukt Chirurg, Forschungs & Behandlungszentrum Sept Defektwunden, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
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   Wang T, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006042
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   Westberg M, 2015, CLIN INFECT DIS, V60, P1752, DOI 10.1093/cid/civ162
   Willy C, 2017, INT WOUND J, V14, P385, DOI 10.1111/iwj.12612
   Wu CT, 2016, J ARTHROPLASTY, V31, P1568, DOI 10.1016/j.arth.2016.01.017
   Xu SG, 2015, INJURY, V46, P184, DOI 10.1016/j.injury.2014.07.026
   Zhang Zhiping, 2015, Zhonghua Wai Ke Za Zhi, V53, P345
   Zhou ZY, 2016, J FOOT ANKLE SURG, V55, P129, DOI 10.1053/j.jfas.2015.08.013
   Zumsteg JW, 2014, J HAND SURG-AM, V39, P956, DOI 10.1016/j.jhsa.2014.02.008
NR 88
TC 11
Z9 12
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0177-5537
EI 1433-044X
J9 UNFALLCHIRURG
JI Unfallchirurg
PD JUN
PY 2017
VL 120
IS 6
BP 472
EP 485
DI 10.1007/s00113-017-0362-x
PG 14
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA EW8TH
UT WOS:000402790500007
PM 28573554
DA 2026-07-24
ER

PT J
AU Evran, M
   Sert, M
   Tetiker, T
   Akkus, G
   Biçer, ÖS
AF Evran, Mehtap
   Sert, Murat
   Tetiker, Tamer
   Akkus, Gamze
   Bicer, Omer Sunkar
TI Spontaneous calcaneal fracture in patients with diabetic foot ulcer:
   Four cases report and review of literature
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Diabetes mellitus; Foot ulcer; Calcaneal fracture
ID BONE-MINERAL DENSITY; OPERATIVE TREATMENT; CHARCOT FOOT; OSTEOMYELITIS;
   NEUROARTHROPATHY
AB Spontaneous calcaneal fractures in diabetic patients without obvious trauma may occur, sometimes accompanying diabetic foot ulcers. In the current study we report four cases who were hospitalized for diabetic foot ulcer with concomitant calcaneal fractures. There were four diabetic patients (one type 1 and three type 2) who registered with diabetic foot ulcers with coexisting calcaneal fractures, all of which were classified as Type A according to Essex Lopresti Calcaneal Fracture Classification. Two of the patients with renal failure were in a routine dialysis program, as well as vascular compromise and osteomyelitis in all of the patients. The diabetic foot ulcer of the 61 years old osteoporotic female patient healed with local debridement, vacuum assisted closure and then epidermal growth factor while the calcaneal fracture was then followed by elastic bandage. In two patients could not prevent progression of diabetic foot ulcers and calcaneal fractures to consequent below-knee amputation. The only patient with type 1 diabetes mellitus improved with antibiotic therapy and split thickness skin grafting, while the calcaneal fracture did not heal. In the current study we aimed to emphasize the spontaneous calcaneal fractures as possible co-existing pathologies in patients with diabetic foot ulcers. After all the medical treatment, amputation below knee had to be performed in 2 patients. It should be noted that other accompanying conditions such as impaired peripheral circulation, osteomyelitis, chronic renal failure, and maybe osteoporosis is a challenge of the recovery of calcaneal fractures and accelerate the progress to amputation in diabetic patients.
C1 [Evran, Mehtap; Sert, Murat; Tetiker, Tamer; Akkus, Gamze] Univ Cukurova Adana, Cukurova Univ, Div Endocrinol, Dept Internal Med,Med Fac, TR-01330 Adana, Turkey.
   [Bicer, Omer Sunkar] Univ Cukurova Adana, Cukurova Univ, Med Fac, Dept Orthoped & Traumatol, TR-01330 Adana, Turkey.
C3 Cukurova University; Cukurova University
RP Evran, M (通讯作者)，Univ Cukurova Adana, Cukurova Univ, Med Fac, Endocrinol,Dept Internal Med,Div Endocrinol, TR-01330 Adana, Turkey.
EM mehtap.evran@hotmail.com
RI akkus, gamze/AAJ-7430-2020; Biçer, Ömer/HSF-3996-2023; Evran,
   Mehtap/G-4823-2018; /G-6103-2018
CR Andersen Lucille B, 2006, Foot Ankle Clin, V11, P825, DOI 10.1016/j.fcl.2006.06.010
   [Anonymous], 2014, CADTH Rapid Response Reports
   Chantelau E, 2007, ARCH ORTHOP TRAUM SU, V127, P171, DOI 10.1007/s00402-006-0271-x
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NR 26
TC 5
Z9 5
U1 0
U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JUL 16
PY 2016
VL 4
IS 7
BP 181
EP 186
DI 10.12998/wjcc.v4.i7.181
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FO9UC
UT WOS:000417241100005
PM 27458594
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Kisch, T
   Liodaki, ME
   Mauss, KL
   Kalousis, K
   Wenzel, ET
   Mailaender, P
   Stang, FH
AF Kisch, Tobias
   Liodaki, Maria E.
   Mauss, Karl L.
   Kalousis, Konstantinos
   Wenzel, Eike T.
   Mailaender, Peter
   Stang, Felix H.
TI Reduced Amputation Rate by Circular TNP Application on Split-Skin Grafts
   After Deep Dermal Foot Scalds in Insulin-Dependent Diabetic Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; LOWER-EXTREMITY; GLOBAL
   PREVALENCE; BURNS; MULTICENTER; STRESS; ULCERS
AB The incidence of insulin-dependent diabetes mellitus (IDDM) is expected to increase significantly. Due to peripheral neuropathy and angiopathy in IDDM patients, feet scalding results in deep burn injuries. Regularly amputations are needed with tremendous consequences. In relatively healthy patients, split-skin graft (SSG) take is better when topical negative pressure (TNP) is applied. We compared the outcome of circular TNP dressing with that of antiseptic dressing on freshly laid SSG after tangential excision in IDDM patients with deep dermal foot scalds. Seventy patients admitted to a burn center with isolated foot burns were identified (2008-2013). Ten of them suffered from IDDM and presented with a deep dermal foot scald. After tangential excision and split-skin grafting, five of them were treated with TNP. The others received an antiseptic dressing regime. Differences were analyzed using either Chi-square or Student's t-test. Group comparison regarding age, gender, body mass index, HbA1c on arrival, glucose in serum, IDDM disease duration, and TBSA revealed no significant differences. But percentage of graft take was at a significantly higher rate in the TNP group (90.2 +/- 4.017 vs 39 +/- 15.362) and fewer operations had to be performed compared to the control group (2.0 +/- 0.447 vs 4.6 +/- 0.927). Due to reduced occurrence of necrosis, the number of amputations required was significantly lower in the TNP group. TNP application on freshly laid SSG following tangential excision in IDDM patients after deep dermal foot scalds minimized amputation rates and therefore is of great benefit for such patients.
C1 [Kisch, Tobias; Liodaki, Maria E.; Mauss, Karl L.; Kalousis, Konstantinos; Wenzel, Eike T.; Mailaender, Peter; Stang, Felix H.] Univ Hosp Schleswig Holstein, Dept Plast Surg, Hand Surg, Burn Unit, D-23538 Lubeck, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital
RP Kisch, T (通讯作者)，Univ Hosp Schleswig Holstein, Dept Plast Surg, Hand Surg, Burn Unit, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.
RI Kalousis, Konstantinos/I-4398-2019; Kisch, Tobias/AAR-4695-2021
OI Kalousis, Konstantinos/0000-0002-3015-0806; Kisch,
   Tobias/0000-0002-0655-2119
CR Al-Qattan MM, 2000, BURNS, V26, P102, DOI 10.1016/S0305-4179(99)00097-2
   [Anonymous], 2010, BMJ
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Brunkhorst FM, 2008, NEW ENGL J MED, V358, P125, DOI 10.1056/NEJMoa070716
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NR 24
TC 9
Z9 10
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD SEP-OCT
PY 2015
VL 36
IS 5
BP E253
EP E258
DI 10.1097/BCR.0000000000000184
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA CT0PM
UT WOS:000362498600001
PM 25412058
DA 2026-07-24
ER

PT J
AU Swanson, EA
   Freeman, LJ
   Seleem, MN
   Snyder, PW
AF Swanson, Elizabeth A.
   Freeman, Lynetta J.
   Seleem, Mohamed N.
   Snyder, Paul W.
TI Biofilm-infected wounds in a dog
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID NEGATIVE-PRESSURE; BACTERIAL; DIVERSITY; DEBRIDEMENT; DIAGNOSTICS;
   THERAPY; CARE
AB Case Description-A 4-year-old spayed female Mastiff was evaluated for treatment of chronic nonhealing pressure wounds over both elbow regions resulting from attempts at hypertrophic callus excision.
   Clinical Findings-The wound bed granulation tissue was mottled red and yellow with hyperemic, rolled epithelial edges. The right wound communicated with a large fluid pocket along the thoracic wall. The dog had an inflammatory leukogram with a left shift.
   Treatment and Outcome-The wounds were debrided, and tissue specimens were collected for histologic evaluation, microbial culture, and bacterial identification by means of molecular diagnostic techniques. The left wound was closed immediately. Calcium alginate rope with silver was packed into the right wound. Vacuum-assisted closure was applied for 6 days. Debridement was repeated, and a thoracodorsal axial pattern flap was used to cover the wound. Systemic treatment with antimicrobials was initiated, and pressure over the elbow regions was relieved. Bacterial biofilms were identified histologically in tissue specimens from both wounds. Staphylococcus intermedius, Staphylococcus epidermidis, and Streptococcus canis were cultured and identified by 16S rRNA fragment sequencing. Pyrosequencing identified multiple bacterial species and no fungal organisms. Both wounds healed successfully.
   Clinical Relevance-Biofilms are implicated in infected orthopedic implants in veterinary patients; however, this is the first report of a bacterial biofilm in chronic wounds in a dog. In human wound care, extensive debridement is performed to disrupt the biofilm; a multimodal treatment approach is recommended to delay reformation and help clear the infection. In this case, biofilm reformation was prevented by systemic treatment with antimicrobials, by reducing local pressure on the wounds, and by wound closure.
C1 [Swanson, Elizabeth A.; Freeman, Lynetta J.] Purdue Univ, Coll Vet Med, Dept Vet Clin Sci, W Lafayette, IN 47907 USA.
   [Seleem, Mohamed N.; Snyder, Paul W.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA.
C3 Purdue University System; Purdue University; Purdue University System;
   Purdue University
RP Swanson, EA (通讯作者)，Mississippi State Univ, Coll Vet Med, Dept Clin Sci, Mississippi State, MS 39762 USA.
EM eswanson@cvm.msstate.edu
RI Seleem, Mohamed/H-2774-2018
OI Seleem, Mohamed/0000-0003-0939-0458; Freeman,
   Lynetta/0000-0002-4077-1497
CR [Anonymous], 2012, EPLASTY
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   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
   Costerton JW, 1999, SCIENCE, V284, P1318, DOI 10.1126/science.284.5418.1318
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   Davis Stephen C, 2006, Curr Diab Rep, V6, P439, DOI 10.1007/s11892-006-0076-x
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   Wolcott R, 2011, PLAST RECONSTR SURG, V127, p28S, DOI 10.1097/PRS.0b013e3181fca244
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   Wolcott RD, 2010, ADV WOUND CARE-SER, V1, P311, DOI 10.1089/awc.2009.0104
NR 31
TC 25
Z9 30
U1 0
U2 34
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD MAR 15
PY 2014
VL 244
IS 6
BP 699
EP 707
DI 10.2460/javma.244.6.699
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AC4LQ
UT WOS:000332493200009
PM 24568112
DA 2026-07-24
ER

PT J
AU Trellu, LT
   Herrmann, FR
   Tarteaut, MH
   Kaya, A
   Cheretakis, A
   Kaya, G
AF Trellu, L. Toutous
   Herrmann, F. R.
   Tarteaut, M. -H.
   Kaya, A.
   Cheretakis, A.
   Kaya, G.
TI Post-traumatic cutaneous hematomas in geriatrics hospital: A neglected
   disease?
SO EUROPEAN GERIATRIC MEDICINE
LA English
DT Article
DE Cutaneous hematomas; Elderly; Management
ID DERMATOPOROSIS; INJURIES; FALLS; RISK
AB Background: Falls in elderly are common and associated to heavy morbidities requiring hospitalizations. Bone and neurosurgical injuries are evaluated in emergency care but many cutaneous hematomas are misdiagnosed or neglected. We aimed to show the epidemiological importance of these skin hemorrhages and help for their management.
   Methods: A retrospective review from specialized consultations reports was performed in the department of geriatrics of the university hospital of Geneva. Measurements were incidence of severe skin hematomas, their epidemiological and clinical characteristics. Details on consecutive care lead to the proposition of a guided structured management.
   Results: A total of 112 (53 parts per thousand - 95% CI = 44.64) hematomas were seen between 2007 and 2010 during 2092 dermatological and surgical consultations at the department of geriatrics of the university hospital of Geneva. Mean age of the patients was 87.4 +/- 7.5 years and a majority of them were women (83.9%). Out of the 112 patients with hematomas 12.5% had diabetes, 39.3% were under antiaggregant therapy and 61.6% under anticoagulant therapy. There was a significant difference concerning sex, age, and anticoagulant therapy between patients presenting with severe hematomas and the geriatric population without hematomas during the observational period (P < 0.001). Among all hematomas, 26 were deep dissecting hematomas. Medicosurgical care included 43 evacuation and drainage, three skin grafts, one vacuum-assisted-closure (VAC) therapy and five transfusions.
   Conclusions: Hematomas often lead to serious morbidity and severe consequences such as anemia or extended wounds. Surgical interventions are required and consequently increase the length of hospital stay and costs. Prevention and management should be clarified. (c) 2012 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.
C1 [Trellu, L. Toutous; Kaya, A.; Kaya, G.] Univ Hosp Geneva, Dept Dermatol, CH-1211 Geneva 14, Switzerland.
   [Trellu, L. Toutous; Herrmann, F. R.; Tarteaut, M. -H.; Cheretakis, A.] Univ Hosp Geneva, Dept Rehabil & Geriatr, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva; University of Geneva
RP Trellu, LT (通讯作者)，Univ Hosp Geneva, Dept Dermatol, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM laurence.trellu@hcuge.ch
RI Herrmann, Francois/B-6710-2011
OI Herrmann, Francois/0000-0003-1312-1517
CR Baker S P, 1985, Clin Geriatr Med, V1, P501
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NR 23
TC 1
Z9 1
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1878-7649
EI 1878-7657
J9 EUR GERIATR MED
JI Eur. Geriatr. Med.
PD APR
PY 2012
VL 3
IS 2
BP 107
EP 111
DI 10.1016/j.eurger.2012.01.005
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 940NC
UT WOS:000303899300008
DA 2026-07-24
ER

PT J
AU Rinker, B
   Amspacher, JC
   Wilson, PC
   Vasconez, HC
AF Rinker, Brian
   Amspacher, Jonathan C.
   Wilson, Patrick C.
   Vasconez, Henry C.
TI Subatmospheric pressure dressing as a bridge to free tissue transfer in
   the treatment of open tibia fractures
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 50th Annual Meeting of the
   Southeastern-Society-of-Plastic-and-Reconstructive-Surgeons
CY JUN 09-13, 2007
CL Destin, FL
SP SE Soc Plastic & Reconstruct Surg
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; WOUND THERAPY;
   LOWER-EXTREMITY; MICROSURGICAL RECONSTRUCTION; TEMPORARY TREATMENT;
   MANAGEMENT; TRAUMA; STATE
AB Background: Free flap reconstruction performed shortly after injury is associated with reduced complications but is not always feasible. Subatmospheric pressure dressings have several beneficial effects on wounds. This study reviewed a large series of open tibia fractures to determine whether subatmospheric pressure dressings affected complication rates.
   Methods: One hundred five patients underwent free muscle flap reconstruction for open tibia fractures between 1991 and 2005. Patients were divided into three groups: acute (flap performed 1 to 7 days after injury), subacute (8 to 42 days after injury), and chronic (>42 days after injury). Five outcome measures were used: infectious complications, flap-related complications, surgical procedures, hospital stay, and time to bony union. The subacute group was divided into patients who underwent subatmospheric pressure dressing therapy and those who did not.
   Results: The complication rate in the subacute group (n = 55) was 47 percent, compared with 39 percent in the chronic group (n = 18) and 31 percent in the acute group (n = 32). Time to union was significantly shorter in the acute group than in the other groups. Subacute patients who underwent subatmospheric dressing therapy had lower overall complication (35 percent), infectious complication (6 percent), and flap-related complication rates (12 percent) than those who did not (53, 18, and 21 percent, respectively). Time to union was significantly shorter with the dressings.
   Conclusion: Subatmospheric pressure dressing therapy as a "bridge" to free flap reconstruction in patients with open tibia fractures was associated with reduced complication rates in the subacute group, suggesting that the dressings may effectively extend the acute period when early free tissue transfer is not possible.
C1 [Rinker, Brian; Amspacher, Jonathan C.; Wilson, Patrick C.; Vasconez, Henry C.] Univ Kentucky, Div Plast Surg, Kentucky Clin, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Rinker, B (通讯作者)，Univ Kentucky, Div Plast Surg, Kentucky Clin, K454, Lexington, KY 40536 USA.
EM brink2@uky.edu
RI Wilson, Patrick/HGC-3157-2022
CR Archdeacon MT, 2006, J ORTHOP TRAUMA, V20, P134, DOI 10.1097/01.bot.0000184147.82824.7c
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 37
TC 51
Z9 57
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAY
PY 2008
VL 121
IS 5
BP 1664
EP 1673
DI 10.1097/PRS.0b013e31816a8d9d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 294VU
UT WOS:000255435200019
PM 18453991
DA 2026-07-24
ER

PT J
AU Hong, YG
   Kim, SC
   Koh, KS
AF Hong, Yoon Gi
   Kim, Sung Chan
   Koh, Kyung S.
TI Flap Preconditioning with the Cyclic Mode (Triangular Waveform) of
   Pressure-Controlled Cupping in a Rat Model: An Alternative Mode to the
   Continuous System
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PATTERN SKIN FLAP; BREAST RECONSTRUCTION;
   CELL-PROLIFERATION; TISSUE-RESPONSE; WOUND THERAPY; SURVIVAL;
   PERFORATOR; BRAVA; AUGMENTATION
AB Background: Improving flap survival is essential for successful soft-tissue reconstruction. Although many methods to increase the survival of the distal flap portion have been attempted, there has been no widely adopted procedure. The authors evaluated the effect of flap preconditioning with two different modes (continuous and cyclic) of external volume expansion (pressure-controlled cupping) in a rat dorsal flap model.
   Methods: Thirty rats were randomly assigned to the control group and two experimental groups (n = 10 per group). The continuous group underwent 30 minutes of preconditioning with -25 mmHg pressure once daily for 5 days. The cyclic group received 0 to -25 mmHg pressure for 30 minutes with the cyclic mode once daily for 5 days. On the day after the final preconditioning, caudally based 2 x 8-cm dorsal random-pattern flaps were raised and replaced in the native position. On postoperative day 9, the surviving flap area was evaluated.
   Results: The cyclic group showed the highest flap survival rate (76.02 percent), followed by the continuous and control groups (64.96 percent and 51.53 percent, respectively). All intergroup differences were statistically significant. Tissue perfusion of the entire flap showed similar results (cyclic, 87.13 percent; continuous, 66.64 percent; control, 49.32 percent). Histologic analysis showed the most increased and organized collagen production with hypertrophy of the attached muscle and vascular density in the cyclic group, followed by the continuous and control groups.
   Conclusion: Flap preconditioning with the cyclic mode of external volume expansion is more effective than the continuous mode in an experimental rat model.
C1 BELIEF Aesthet Plast Hosp, Hangzhou, Zhejiang, Peoples R China.
   [Koh, Kyung S.] Univ Ulsan, Asan Med Center, Dept Plast & Reconstruct Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
C3 University of Ulsan
RP Koh, KS (通讯作者)，Univ Ulsan, Asan Med Center, Dept Plast & Reconstruct Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM kskoh@amc.seoul.kr
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NR 50
TC 11
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2019
VL 143
IS 1
BP 88E
EP 98E
DI 10.1097/PRS.0000000000005104
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HG6CA
UT WOS:000455067400009
PM 30325895
DA 2026-07-24
ER

PT J
AU Coakley, DN
   Shaikh, FM
   O'Sullivan, K
   Kavanagh, EG
   Grace, PA
   McGloughlin, TM
AF Coakley, Daniel N.
   Shaikh, Faisal M.
   O'Sullivan, Kathleen
   Kavanagh, Eamon G.
   Grace, Pierce A.
   McGloughlin, Tim M.
TI Design and evaluation of a novel subatmospheric pressure bioreactor for
   the preconditioning of tissue-engineered vascular constructs
SO INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
LA English
DT Article
DE Bioreactor; Tissue-engineering; Biomaterials; Vascular sugery
ID WOUND THERAPY; SHEAR-STRESS; MECHANICAL STRAIN; PROLIFERATION; CELLS
AB Purpose: The pre-conditioning of tissue-engineered vascular scaffolds with mechanical stimuli is being recognised as an essential step in producing a functional vascular construct. In this study we design and evaluate a novel bioreactor, which exerts a mechanical strain on developing vascular scaffolds via subatmospheric pressure.
   Methods: We design and construct a bioreactor, which exerts subatmospheric pressure via a vacuum assisted closure unit. Vascular scaffolds seeded with human umbilical endothelial cells were evaluated for structural integrity, microbial contamination, cellular viability, von Willebrand factor (VWF) production, cell proliferation and morphology under a range of subatmospheric pressures (75-200mmHg).
   Results: The bioreactor produced sustained subatmospheric pressures, which exerted a mechanical strain on the vascular scaffold. No microbial contamination was found during the study. The structural integrity of the vascular construct was maintained. There was no difference in cellular viability between control or subatmospheric pressure groups (p = 0.817). Cells continued to produce VWF under a range of subatmospheric pressures. Cells subjected to subatmospheric pressures of 125mmHg and 200mmHg exhibited higher levels of growth than cells in atmospheric pressure at 24 (p = 0.016) and 48 hour (p = 0.001). Negative pressure affected cellular morphology, which were more organised, elongated and expanded when exposed to subatmospheric pressure.
   Conclusions: We have constructed and validated a novel subatmospheric bioreactor. The bioreactor maintained a continuous subatmospheric pressure to the vascular scaffolds in a stable, sterile and constant environment. The bioreactor exerted a strain on the vascular sheets, which was shown to alter cellular morphology and enhance cellular proliferation.
C1 [Coakley, Daniel N.; Shaikh, Faisal M.; Kavanagh, Eamon G.; Grace, Pierce A.] Univ Hosp Limerick, Dept Vasc Surg, Limerick, Ireland.
   [O'Sullivan, Kathleen] Natl Univ Ireland Univ Coll Cork, Sch Math Sci, Stat Consultancy Unit, Cork, Ireland.
   [McGloughlin, Tim M.] Khalifa Univ Sci Technol & Res KUSTAR, Dept Biomed Engn, Abu Dhabi, U Arab Emirates.
C3 University of Limerick; University College Cork; Khalifa University of
   Science & Technology
RP Coakley, DN (通讯作者)，Univ Hosp Limerick, Dept Vasc Surg, Limerick, Ireland.
EM drdanielcoakley@gmail.com
RI ; McGloughlin, Tim/G-9526-2015; Shaikh, Faisal/LRC-9231-2024
OI Coakley, Daniel/0000-0003-1262-2782; McGloughlin,
   Tim/0000-0003-3519-8988; 
FU Royal College of Surgeons Ireland Research Grant [311257]
FX The work was funded by the Royal College of Surgeons Ireland Research
   Grant (Ref. 311257).
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 29
TC 2
Z9 2
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0391-3988
EI 1724-6040
J9 INT J ARTIF ORGANS
JI Int. J. Artif. Organs
PD FEB
PY 2016
VL 39
IS 2
BP 77
EP 83
DI 10.5301/ijao.5000475
PG 7
WC Engineering, Biomedical; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Transplantation
GA DL1HR
UT WOS:000375383700006
PM 26953899
DA 2026-07-24
ER

PT J
AU Moghadamyeghaneh, Z
   Hanna, MH
   Carmichael, JC
   Mills, S
   Pigazzi, A
   Nguyen, NT
   Stamos, MJ
AF Moghadamyeghaneh, Zhobin
   Hanna, Mark H.
   Carmichael, Joseph C.
   Mills, Steven
   Pigazzi, Alessio
   Nguyen, Ninh T.
   Stamos, Michael J.
TI Wound Disruption Following Colorectal Operations
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MIDLINE LAPAROTOMY; INCISIONAL HERNIAS;
   RISK-FACTORS; DEHISCENCE; HYPOALBUMINEMIA; CORTICOSTEROIDS; PREDICTOR;
   TRIAL
AB Postoperative wound disruption is associated with high morbidity and mortality. We sought to identify the risk factors and outcomes of wound disruption following colorectal resection.
   The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database was used to examine the clinical data of patients who underwent colorectal resection from 2005 to 2013. Multivariate regression analysis was performed to identify risk factors of wound disruption.
   We sampled a total of 164,297 patients who underwent colorectal resection. Of these, 2073 (1.3 %) had wound disruption. Patients with wound disruption had significantly higher mortality (5.1 vs. 1.9 %, AOR: 1.46, P = 0.01). The highest risk of wound disruption was seen in patients with wound infection (4.8 vs. 0.9 %, AOR: 4.11, P < 0.01). A number of factors are associated with wound disruption such as chronic steroid use (AOR: 1.71, P < 0.01), smoking (AOR: 1.60, P < 0.01), obesity (AOR: 1.57, P < 0.01), operation length more than 3 h (AOR: 1.56, P < 0.01), severe Chronic Obstructive Pulmonary Disease (COPD) (AOR: 1.36, P < 0.01), urgent/emergent admission (AOR: 1.31, P = 0.01), and serum Albumin Level < 3 g/dL (AOR: 1.27, P < 0.01). Laparoscopic surgery had significantly lower risk of wound disruption compared to open surgery (AOR: 0.61, P < 0.01).
   Wound disruption occurs in 1.3 % of colorectal resections, and it correlates with mortality of patients. Wound infection is the strongest predictor of wound disruption. Chronic steroid use, obesity, severe COPD, prolonged operation, non-elective admission, and serum albumin level are strongly associated with wound disruption. Utilization of the laparoscopic approach may decrease the risk of wound disruption when possible.
C1 [Moghadamyeghaneh, Zhobin; Hanna, Mark H.; Carmichael, Joseph C.; Mills, Steven; Pigazzi, Alessio; Nguyen, Ninh T.; Stamos, Michael J.] Univ Calif Davis, Sch Med, Dept Surg, Irvine, CA 95616 USA.
   [Stamos, Michael J.] John E Connolly Chair Surg, Orange, CA 92868 USA.
C3 University of California System; University of California Davis
RP Stamos, MJ (通讯作者)，Univ Calif Davis, Sch Med, Dept Surg, Irvine, CA 95616 USA.
EM mstamos@uci.edu
RI ; Stamos, Michael/I-2465-2019
OI Carmichael, Joseph/0000-0003-2738-7113; Stamos,
   Michael/0000-0003-2068-7391; Yeganeh, Zhobin/0000-0002-3802-4505
CR *AM COLL SURG, 2005, NAT SURG QUAL IMPR P
   American College of Surgeons National Surgical Quality Im-provement Program, 2012, US GUID 2011 PART US
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NR 38
TC 12
Z9 14
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD DEC
PY 2015
VL 39
IS 12
BP 2999
EP 3007
DI 10.1007/s00268-015-3208-0
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CV8KO
UT WOS:000364534100021
PM 26304611
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Saffle, JR
   Morris, SE
   Edelman, L
AF Saffle, Jeffrey R.
   Morris, Stephen E.
   Edelman, Linda
TI Fournier's gangrene: Management at a regional burn center
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article; Proceedings Paper
CT 39th Annual Meeting of the American-Burn-Association
CY MAR 22-25, 2007
CL San Diego, CA
SP Amer Burn Assoc
ID FASCIITIS REDUCES MORTALITY; HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED
   CLOSURE; NECROTIZING FASCIITIS; INFECTIONS; EXPERIENCE; CARE
AB Fournier's gangrene (FG) describes necrotizing infections of the perineum in both sexes. Controversies in treatment of FG include the roles of orchiectomy, urinary and/or fecal diversion, and hyperbaric oxygen (HBO). Because burn centers often treat these patients, we reviewed our experience with FG during a 14-year period. With Institutional Review Board approval, we reviewed our TRACS (TM)/ABA database for patients treated for FG during 1992 to 2005. Data was recorded on demographics, preexisting medical conditions, treatment, and outcomes. Thirty patients (20 men) were identified. Mean age was 54.3 +/- 14.1 years. Predisposing conditions included diabetes in 16 patients (53%), and morbid obesity and inummosuppression in 6 each. Twenty-two patients were transferred from outside hospitals, 12 after initial surgery. Sixteen patients presented with shock (blood pressure < 90/60 nun Hg). Patients underwent a mean of 4.1 surgical procedures. Ten infections penetrated the deep fascia of the perineum or abdominal wall. Suprapubic cystostomy was performed in three patients, colostomy in seven, orchiectomy in one. HBO was not used. Hospitalization averaged 25.3 +/- 15.6 days. Mean charges ($1000) were $131.5 +/- 108.3. Definitive wound closure was obtained before discharge with suture repair and/or skin grafting in 18 of 25 survivors (72%). Five patients died (17%). In logistic regression analysis, the presence of shock on admission and female gender (mortality 40%) were significantly associated with mortality. FG remains a devastating infection, which occurs primarily in compromised patients. In this series, aggressive burn center care produced outcomes equivalent to those published in other series with or without use of HBO. Colostomy and urinary diversion can be used very selectively in these patients; orchiectomy is rarely required.
C1 [Saffle, Jeffrey R.; Morris, Stephen E.; Edelman, Linda] Univ Utah, Hlth Sci Ctr, Dept Surg, Burn Trauma Ctr, Salt Lake City, UT 84132 USA.
C3 Utah System of Higher Education; University of Utah
RP Saffle, JR (通讯作者)，Univ Utah, Hlth Sci Ctr, Dept Surg, Burn Trauma Ctr, 3B-306,50 N Med Dr, Salt Lake City, UT 84132 USA.
RI Edelman, Linda/AAD-9193-2022
OI Edelman, Linda/0000-0002-8903-0083
CR Anaya DA, 2007, CLIN INFECT DIS, V44, P705, DOI 10.1086/511638
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NR 29
TC 15
Z9 17
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD JAN-FEB
PY 2008
VL 29
IS 1
BP 196
EP 203
DI 10.1097/BCR.0b013e318160daba
PG 8
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Dermatology; Surgery
GA 252OE
UT WOS:000252455000032
PM 18182922
DA 2026-07-24
ER

PT J
AU Palazzo, JF
   Santos, M
   Adler, B
   Besen, P
   Sambo, C
   Leite, GFD
   Gallafrio, ST
   Gualandro, DM
   Cuello, LPB
   Santos, MVB
   Strabelli, TMV
   Pomerantzeff, PMA
   Jatene, FB
   Siciliano, R
AF Palazzo, Jaqueline Fabiano
   Santos, Medeiros
   Adler, Bruno
   Besen, Pinheiro
   Sambo, Caio
   Leite, Gabriel Fialkovitz da Costa
   Gallafrio, Samuel Terra
   Gualandro, Danielle Menosi
   Cuello, Lani Paola Bonilla
   Santos, Marcus Vinicius Barbosa
   Strabelli, Tania Mara Varejao
   Pomerantzeff, Pablo Maria Alberto
   Jatene, Fabio Biscegli
   Siciliano, Rinaldo
TI Clinical and Microbiology Predictors for Therapeutic Failure in Sternal
   Surgical Site Infections-A Retrospective Cohort Study
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA Portuguese
DT Article
DE Surgical Wound Infection; Thoracic Surgery; Mediastinitis; Treatment
   Failure
ID VACUUM-ASSISTED CLOSURE; CARE-ASSOCIATED INFECTIONS; PRESSURE WOUND
   THERAPY; RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS;
   STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; CARDIAC-SURGERY;
   COMPLICATIONS; PREVENTION
AB Background: Although sternal surgical site infections (SSI) are an important complication after cardiac surgeries, predictors of treatment failure are poorly studied. Objectives: The aim of this study is to assess the clinical and microbiology predictors of a sternal SSI therapeutic failure.<br /> Methods: Patients who presented a sternal SSI were retrospectively analyzed. Data regarding demographic characteristics, clinical findings, initial laboratory and radiologic findings and treatment of index sternal SSI were evaluated. Primary outcome was treatment failure, comprising infection relapse (clinical sternal SSI after complete treatment) or infection persistence (outpatient antimicrobial treatment failure). The microbiology was assessed at the index infection and in the outcome. P-values < 0.05 were considered statistically significant. Results: Among 489 included patients, mean age was 58 years, 265 (55%) were female, 185 (38%) had diabetes mellitus. The overall prevalence of therapeutic failure was 14% (67), occurring in a median of 174 days (+/- 41) after index cardiac surgery. Most frequent etiologies were cocci Grampositive and Klebsiella pneumoniae. None of laboratory or thoracic tomographic findings presented during the index sternal SSI was related to outcome. After multivariate analysis, Staphylococcus aureus, carbapenem-resistant Gram-negative bacilli (GNB), fungi, diabetes mellitus and presence of mediastinitis/osteomyelitis were positive predictors of therapeutic failure. Conclusions: Emerging carbapenem-resistant GNB, fungi and S. aureus were etiologies associated with higher risk of therapeutic failure in sternal SSI. DM and deep sternal wound infections were also contributing factors. Its clinical implications and the exact role of multi-resistant microorganism itself are subject for more studies.
C1 [Palazzo, Jaqueline Fabiano; Santos, Medeiros; Adler, Bruno; Besen, Pinheiro; Sambo, Caio; Leite, Gabriel Fialkovitz da Costa; Gallafrio, Samuel Terra; Gualandro, Danielle Menosi; Cuello, Lani Paola Bonilla; Santos, Marcus Vinicius Barbosa; Strabelli, Tania Mara Varejao; Pomerantzeff, Pablo Maria Alberto; Jatene, Fabio Biscegli; Siciliano, Rinaldo] Univ Sao Paulo, Hosp Clin, Fac Med, Inst Coracao, Ave Dr Eneas Carvalho Aguiar 44, BR-05403000 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Sambo, C (通讯作者)，Univ Sao Paulo, Hosp Clin, Fac Med, Inst Coracao, Ave Dr Eneas Carvalho Aguiar 44, BR-05403000 Sao Paulo, SP, Brazil.
EM caiosambo1912@gmail.com
RI Strabelli, Tânia/B-1857-2015; /L-5525-2016; Jatene, Fabio/D-1679-2012
OI Strabelli, Tânia/0000-0003-1955-1008; 
CR Abboud CS, 2016, INT J ANTIMICROB AG, V47, P386, DOI 10.1016/j.ijantimicag.2016.02.015
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   Mora-Guzmán I, 2020, CIR ESPAN, V98, P342, DOI 10.1016/j.ciresp.2019.11.006
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   OTTINO G, 1987, ANN THORAC SURG, V44, P173, DOI 10.1016/S0003-4975(10)62035-8
   Perrault LP, 2018, ANN THORAC SURG, V105, P461, DOI 10.1016/j.athoracsur.2017.06.078
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Redzek A, 2015, J CARDIAC SURG, V30, P1, DOI 10.1111/jocs.12441
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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   Steingrimsson S, 2012, INTERACT CARDIOV TH, V15, P406, DOI 10.1093/icvts/ivs254
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NR 41
TC 1
Z9 2
U1 0
U2 1
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PY 2025
VL 122
IS 4
AR e20240464
DI 10.36660/abc.20240464
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2ZX4P
UT WOS:001495306700001
PM 40396864
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Rodrigues-Pinto, E
   Pereira, P
   Sousa-Pinto, B
   Shehab, H
   Pinho, R
   Larsen, MC
   Irani, S
   Kozarek, RA
   Capogreco, A
   Repici, A
   Shemmeri, E
   Louie, BE
   Rogalski, P
   Baniukiewicz, A
   Dabrowski, A
   de Sousa, JC
   Barrias, S
   Ichkhanian, Y
   Kumbhari, V
   Khashab, MA
   Bowers, N
   Schulman, AR
   Macedo, G
AF Rodrigues-Pinto, Eduardo
   Pereira, Pedro
   Sousa-Pinto, Bernardo
   Shehab, Hany
   Pinho, Rolando
   Larsen, Michael C.
   Irani, Shayan
   Kozarek, Richard A.
   Capogreco, Antonio
   Repici, Alessandro
   Shemmeri, Ealaf
   Louie, Brian E.
   Rogalski, Pawel
   Baniukiewicz, Andrzej
   Dabrowski, Andrzej
   de Sousa, Joao Correia
   Barrias, Silvia
   Ichkhanian, Yervant
   Kumbhari, Vivek
   Khashab, Mouen A.
   Bowers, Nicole
   Schulman, Allison R.
   Macedo, Guilherme
TI Retrospective multicenter study on endoscopic treatment of upper GI
   postsurgical leaks
SO GASTROINTESTINAL ENDOSCOPY
LA English
DT Article
ID EXPANDABLE METAL STENTS; VACUUM-ASSISTED CLOSURE; ANASTOMOTIC LEAKAGE;
   SLEEVE GASTRECTOMY; BARIATRIC SURGERY; MANAGEMENT; ESOPHAGECTOMY;
   FISTULAS; THERAPY
AB Background and Aims: Therapeutic endoscopy plays a critical role in the management of upper GI (UGI) postsurgical leaks. Data are scarce regarding clinical success and safety. Our aim was to evaluate the effectiveness of endoscopic therapy for UGI postsurgical leaks and associated adverse events (AEs) and to identify factors associated with successful endoscopic therapy and AE occurrence.
   Methods: This was a retrospective, multicenter, international study of all patients who underwent endoscopic therapy for UGI postsurgical leaks between 2014 and 2019.
   Results: Two hundred six patients were included. Index surgery most often performed was sleeve gastrectomy (39.3%), followed by gastrectomy (23.8%) and esophagectomy (22.8%). The median time between index surgery and commencement of endoscopic therapy was 16 days. Endoscopic closure was achieved in 80.1% of patients after a median follow-up of 52 days (interquartile range, 33-81.3). Seven hundred seventy-five therapeutic endoscopies were performed. Multimodal therapy was needed in 40.8% of patients. The cumulative success of leak resolution reached a plateau between the third and fourth techniques (approximately 70%-80%); this was achieved after 125 days of endoscopic therapy. Smaller leak initial diameters, hospitalization in a general ward, hemodynamic stability, absence of respiratory failure, previous gastrectomy, fewer numbers of therapeutic endoscopies performed, shorter length of stay, and shorter times to leak closure were associated with better outcomes. Overall, 102 endoscopic therapy-related AEs occurred in 81 patients (39.3%), with most managed conservatively or endoscopically. Leak-related mortality rate was 12.4%.
   Conclusions: Multimodal therapeutic endoscopy, despite being time-consuming and requiring multiple procedures, allows leak closure in a significant proportion of patients with a low rate of severe AEs.
C1 [Rodrigues-Pinto, Eduardo; Pereira, Pedro; Macedo, Guilherme] Ctr Hosp Sao Joao, Gastroenterol Dept, P-4200319 Porto, Portugal.
   [Sousa-Pinto, Bernardo] Univ Porto, Fac Med, Dept Community Med Informat & Hlth Decis Sci, MEDCIDS, Porto, Portugal.
   [Sousa-Pinto, Bernardo] Ctr Hlth Technol & Serv Res, CINTESIS, Porto, Portugal.
   [Shehab, Hany] Cairo Univ Hosp, Gastroenterol Dept, Cairo, Egypt.
   [Pinho, Rolando] Ctr Hosp Vila Nova de Gaia Espinho, Dept Gastroenterol, Vila Nova De Gaia, Portugal.
   [Larsen, Michael C.; Irani, Shayan; Kozarek, Richard A.] Virginia Mason Med Ctr, Dept Gastroenterol & Hepatol, Seattle, WA 98101 USA.
   [Capogreco, Antonio; Repici, Alessandro] Humanitas Univ, Humanitas Res Hosp, Digest Endoscopy Unit, Milan, Italy.
   [Shemmeri, Ealaf; Louie, Brian E.] Swedish Canc Inst, Div Thorac Surg, Seattle, WA USA.
   [Rogalski, Pawel; Baniukiewicz, Andrzej; Dabrowski, Andrzej] Med Univ Bialystok, Dept Gastroenterol & Internal Med, Bialystok, Poland.
   [de Sousa, Joao Correia; Barrias, Silvia] Ctr Hosp Porto, Dept Gastroenterol, Hosp Santo Antonio, Porto, Portugal.
   [Ichkhanian, Yervant; Kumbhari, Vivek; Khashab, Mouen A.] Johns Hopkins Med Inst, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA.
   [Bowers, Nicole; Schulman, Allison R.] Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI USA.
C3 Sao Joao Hospital; Universidade do Porto; Universidade do Porto;
   Egyptian Knowledge Bank (EKB); Cairo University; Cairo University
   Hospital; Virginia Mason Medical Center; Humanitas University; Swedish
   Health Services; Swedish Cancer Institute; Medical University of
   Bialystok; Johns Hopkins University; Johns Hopkins Medicine; University
   of Michigan System; University of Michigan
RP Rodrigues-Pinto, E (通讯作者)，Ctr Hosp Sao Joao, Gastroenterol Dept, P-4200319 Porto, Portugal.
EM edu.gil.pinto@gmail.com
RI Sousa-Pinto, Bernardo/O-2846-2014; Pereira, Pedro/AAD-6736-2022;
   khashab, mouen/F-6643-2017; Louie, Brian/AAJ-1840-2020; shehab,
   hany/HLW-0956-2023; Repici, Alessandro/HFH-8162-2022; Dąbrowski,
   Anzej/T-8656-2018; Macedo, Guilherme/L-8038-2013; Rogalski,
   Paweł/T-6173-2018; Kozarek, Richard/AAF-2695-2020; Capogreco,
   Antonio/LSK-6717-2024
OI Sousa-Pinto, Bernardo/0000-0002-1277-3401; Rodrigues-Pinto,
   Eduardo/0000-0002-2239-1650; shehab, hany/0000-0003-1816-871X; Repici,
   Alessandro/0000-0002-1621-6450; Dąbrowski, Anzej/0000-0002-5996-394X;
   Macedo, Guilherme/0000-0002-9387-9872; Rogalski,
   Paweł/0000-0002-1884-2500; Kozarek, Richard/0000-0002-9745-7538;
   Capogreco, Antonio/0000-0002-2212-2266
CR Anderloni A, 2019, DIGEST SURG, V36, P309, DOI 10.1159/000489817
   Baptista A, 2019, GASTROINTEST ENDOSC, V89, P671, DOI 10.1016/j.gie.2018.11.034
   Bège T, 2011, GASTROINTEST ENDOSC, V73, P238, DOI 10.1016/j.gie.2010.10.010
   Blencowe NS, 2012, ANN SURG, V255, P658, DOI 10.1097/SLA.0b013e3182480a6a
   Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
   Brangewitz M, 2013, ENDOSCOPY, V45, P433, DOI 10.1055/s-0032-1326435
   Christophorou D, 2015, ENDOSCOPY, V47, P988, DOI 10.1055/s-0034-1392262
   El Hajj II, 2014, GASTROINTEST ENDOSC, V79, P589, DOI 10.1016/j.gie.2013.08.039
   Farnik H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117483
   Gonzalez R, 2007, J AM COLL SURGEONS, V204, P47, DOI 10.1016/j.jamcollsurg.2006.09.023
   Kumar Nitin, 2013, Gastrointest Endosc Clin N Am, V23, P123, DOI 10.1016/j.giec.2012.10.002
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   Laukoetter MG, 2017, SURG ENDOSC, V31, P2687, DOI 10.1007/s00464-016-5265-3
   Lorenzo D, 2018, GASTROINTEST ENDOSC, V87, P429, DOI 10.1016/j.gie.2017.07.032
   Manta R, 2016, UNITED EUR GASTROENT, V4, P770, DOI 10.1177/2050640615626051
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   Rodrigues-Pinto E, 2016, REV ESP ENFERM DIG, V108, P133, DOI 10.17235/reed.2016.3987/2015
   Rutegård M, 2012, ANN SURG ONCOL, V19, P99, DOI 10.1245/s10434-011-1926-6
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NR 34
TC 18
Z9 22
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0016-5107
EI 1097-6779
J9 GASTROINTEST ENDOSC
JI Gastrointest. Endosc.
PD JUN
PY 2021
VL 93
IS 6
BP 1283
EP +
DI 10.1016/j.gie.2020.10.015
EA MAY 2021
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SF5ZR
UT WOS:000652833900012
PM 33075368
DA 2026-07-24
ER

PT J
AU Zosimas, D
   Lykoudis, PM
   Ivanov, B
   Hepworth, C
AF Zosimas, Dimitrios
   Lykoudis, Panagis M.
   Ivanov, Bogdan
   Hepworth, Clive
TI Laparostomy and temporary abdominal closure outcomes in emergency
   non-trauma surgery and parameters affecting early definite primary
   fascial closure
SO MINERVA CHIRURGICA
LA English
DT Article
DE Laparotomy; Mortality; Morbidity
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN;
   NEGATIVE-PRESSURE; GASTROINTESTINAL SURGERY; BOGOTA BAG; MANAGEMENT;
   EXPERIENCE; PERITONITIS
AB BACKGROUND: The open abdomen or lapamstomy is a great advance of surgery based on the concept of damage control surgery. Aim of the study is to review the laparostomy outcomes of non-trauma emergency surgery patients in a district general hospital and identify parameters affecting early definite primary fascia! closure.
   METHODS: The records of all non-trauma emergency surgical patients who underwent laparostomy in a three-year period in a single institute were studied retrospmtively. Outcomes included length of stay, morbidity, mortality, readmission rates, number of re-look operations, rate of definite primary fascia! closure and time to closure.
   RESULTS: Thirty-two patients were included. Morbidity was 84.4% and mortality rates were 21.9% (in-hospital), 18.8% (30-day) and 46.9% (overall). Median length of hospital stay was 22 days. Rate of primary fascial closure was 87.5% and median time to closure was two days. The number of retook operations was the only independent prognostic factor of definite early primary fascia! closure, with higher rates of closure in patients with 1-2 relooks.
   CONCLUSIONS: Although the open abdomen has been demonstrated to improve survival, the precise role in abdominal sepsis has not been elucidated. Current consensus does not support use of open abdomen routinely. however in selected situations it becomes unavoidable. Laparostomy is a valid option in non-trauma emergency surgery and can be managed safely in a district hospital. High closure rates can be achieved if one or two re-look operations are performed with an early attempt for closure.
C1 [Zosimas, Dimitrios; Ivanov, Bogdan; Hepworth, Clive] Barking Havering & Redbridge Univ Hosp NHS Trust, Queens Hosp, Dept Gen Surg, Rom Valley Way,RM7 0AG, Romford, Essex, England.
   [Lykoudis, Panagis M.] UCL, Div Surg & Intervent Sci, London, England.
C3 University of London; University College London
RP Zosimas, D (通讯作者)，Barking Havering & Redbridge Univ Hosp NHS Trust, Queens Hosp, Dept Gen Surg, Rom Valley Way,RM7 0AG, Romford, Essex, England.
EM dizos@yahoo.com
RI Lykoudis, Panagis/I-7590-2012
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   Atema JJ, 2015, WORLD J SURG, V39, P912, DOI 10.1007/s00268-014-2883-6
   Balentine C, 2009, AM J SURG, V198, P588, DOI 10.1016/j.amjsurg.2009.07.023
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
   Bertelsen CA, 2014, WORLD J SURG, V38, P774, DOI 10.1007/s00268-013-2360-7
   Cheatham ML, 2013, WORLD J SURG, V37, P2018, DOI 10.1007/s00268-013-2080-z
   Chen Y, 2014, GASTROENT RES PRACT, V2014, DOI 10.1155/2014/784056
   Coccolini F, 2015, WORLD J EMERG SURG, V10, DOI 10.1186/s13017-015-0026-5
   Cristaudo A, 2017, AM SURGEON, V83, P191
   De Siqueira J, 2014, ANN ROY COLL SURG, V96, P194, DOI 10.1308/003588414X13814021678556
   Demetriades D, 2014, SURG CLIN N AM, V94, P131, DOI 10.1016/j.suc.2013.10.010
   Fortelny RH, 2014, SURG ENDOSC, V28, P735, DOI 10.1007/s00464-013-3251-6
   Gönüllü D, 2009, ULUS TRAVMA ACIL CER, V15, P52
   Goussous N, 2014, INJURY, V45, P151, DOI 10.1016/j.injury.2013.01.039
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   Schachtrupp A, 2002, Hernia, V6, P155
   Schein M, 2002, LANGENBECK ARCH SURG, V387, P1, DOI 10.1007/s00423-002-0276-z
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   Siddiqui SS, 2012, PAK J MED SCI, V28, P450
   Teixeira PGR, 2008, AM SURGEON, V74, P891
   Thompson JM, 2011, WOUND PRACT RES, V19, P160
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NR 41
TC 1
Z9 1
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4733
EI 1827-1626
J9 MINERVA CHIR
JI Minerva Chir.
PD DEC
PY 2020
VL 75
IS 6
BP 419
EP 425
DI 10.23736/S0026-4733.20.08320-0
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PU3KI
UT WOS:000609203200006
PM 32456399
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Gesslein, B
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjoe, Malin
   Gesslein, Bodil
   Ingemansson, Richard
TI Evaluation of continuous and intermittent myocardial topical negative
   pressure
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE collateral blood flow; ischemia; myocardium; topical negative pressure
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; ENDOTHELIAL GROWTH-FACTOR;
   STERNAL WOUND-INFECTION; PERISTERNAL THORACIC WALL;
   CORONARY-ARTERY-DISEASE; BYPASS GRAFT-SURGERY; BLOOD-FLOW; RISK-FACTORS;
   POSTSTERNOTOMY MEDIASTINITIS
AB Objective Topical negative pressure, commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in subcutaneous tissue and skeletal muscle. In wound therapy, intermittent negative pressure is often preferred to continuous negative pressure as tissue exposed to intermittent therapy shows twice as much granulation tissue formation than that exposed to continuous pressure after 2 weeks of therapy. The present study was designed to elucidate the differences in microvascular blood flow in the left anterior descending artery area between continuous and intermittent myocardial topical negative pressure of -50 mmHg.
   Methods Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the left anterior descending artery area at depths of approximately 5-6 mm. Measurements of microvascular blood flow were performed in normal myocardium and ischemic myocardium during 20 min of countinuous and intermittent topical negative pressure at -50 mmHg.
   Results Both continuous and intermittent topical negative pressure of -50 mmHg significantly increased microvascular blood flow in the underlying myocardium: from 56.2 +/- 13.1 perfusion units (PU) before to 132.8 +/- 7.4 PU during countinuous topical negative pressure application (P < 0.05) and from 75.8 +/- 12.1 PU before to 153.6 +/- 4.7 PU during intermittent topical negative pressure application (P < 0.05).
   Conclusion No statistically significant difference was found between microvascular blood flow during 20 min of continuous and intermittent topical negative pressure at -50 mmHg in this porcine model.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   [Malmsjoe, Malin; Gesslein, Bodil] Univ Lund Hosp, Dept Med, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 37
TC 7
Z9 9
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD AUG
PY 2008
VL 9
IS 8
BP 813
EP 819
DI 10.2459/JCM.0b013e3282f85bda
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 331XS
UT WOS:000258046500010
PM 18607247
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Ingemansson, Richard
TI No hypoperfusion is produced in the epicardium during application of
   myocardial topical negative pressure in a porcine model
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; STERNAL
   WOUND-INFECTION; LONG-TERM SURVIVAL; ANGIOGENIC GENE-THERAPY;
   RISK-FACTORS; MEDIASTINITIS; EXPRESSION; COMPLICATIONS; IMPACT
AB Background: Topical negative pressure (TNP), commonly used in wound therapy, has been shown to increase blood flow and stimulate angiogenesis in skeletal muscle. We have previously shown that a myocardial TNP of -50 mmHg significantly increases microvascular blood flow in the myocardium. When TPN is used in wound therapy (on skeletal and subcutaneous tissue) a zone of relative hypoperfusion is seen close to the wound edge. Hypoperfusion induced by TNP is thought to depend on tissue density, distance from the negative pressure source, and the amount negative pressure applied. When applying TNP to the myocardium, a significant, long-standing zone of hypoperfusion could theoretically cause ischemia, and negative effects on the myocardium. The current study was designed to elucidate whether hypoperfusion was produced during myocardial TNP.
   Methods: Six pigs underwent median sternotomy. Laser Doppler probes were inserted horizontally into the heart muscle in the LAD area, at depths of approximately, 1-2 mm. The microvascular blood flow was measured before and after the application of a TNP. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischemic myocardium).
   Results: A TNP of -50 mmHg induced a significant increase in microvascular blood flow in normal myocardium (**p = 0.01), while -125 mmHg did not significantly alter the microvascular blood flow. In ischemic myocardium a TNP of -50 mmHg induced a significant increase in microvascular blood flow (*p = 0.04), while -125 mmHg did not significantly alter the microvascular blood flow.
   Conclusion: No hypoperfusion could be observed in the epicardium in neither normal nor ischemic myocardium during myocardial TNP.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se; malin.malmsjo@skane.se;
   richard.ingemansson@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
FU Anders Otto Sward's Foundation/Ulrika Eklund's Foundation; Anna Lisa and
   Sven Eric Lundgren's Foundation; Ake Wiberg Foundation; M. Bergvall
   Foundation; Swedish Medical Association; Royal Physiographic Society in
   Lund; Swedish Medical Research Council; Crafoord Foundation; Swedish
   Heart-Lung Foundation; Swedish Government; Swedish Hypertension Society
FX We would like to thank Johan Ingemansson (Statistical Solutions IP) for
   his expert contribution to the statistic analyses. This study was
   supported by Anders Otto Sward's Foundation/Ulrika Eklund's Foundation,
   Anna Lisa and Sven Eric Lundgren's Foundation for medical research, the
   Ake Wiberg Foundation, the M. Bergvall Foundation, the Swedish Medical
   Association, the Royal Physiographic Society in Lund, the Swedish
   Medical Research Council, the Crafoord Foundation, the Swedish
   Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research, and the Swedish Hypertension Society.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 34
TC 8
Z9 10
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PY 2007
VL 2
AR 53
DI 10.1186/1749-8090-2-53
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA V83HU
UT WOS:000205631000053
PM 18062803
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Alayed, H
   Hsu, AHS
   Wu, KT
   Wu, CT
   Lin, PC
   Kuo, FC
AF Alayed, Hisham
   Hsu, Allen Herng Shouh
   Wu, Kuan-Ting
   Wu, Cheng-Ta
   Lin, Po-Chun
   Kuo, Feng-Chih
TI The effect of post-operative continuous negative pressure therapy after
   debridement, antibiotics, and implant retention for acute periprosthetic
   joint infection
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Periprosthetic joint infection; DAIR; Continuous negative pressure
   therapy; Total knee arthroplasty; Total hip arthroplasty
ID VACUUM-ASSISTED CLOSURE; HIP-ARTHROPLASTY; TREATMENT OPTION;
   RISK-FACTORS; IRRIGATION; DAIR; EXCHANGE; OUTCOMES; SUCCESS; MANAGEMENT
AB BackgroundAcute periprosthetic joint infection (PJI) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute knee and hip PJI.MethodsIn this retrospective study from October 2018 to December 2022, 62 patients diagnosed with acute PJI were divided into two groups: 24 patients treated with DAIR and CNPT, and 38 patients treated with DAIR alone. The groups were comparable in terms of patient characteristics, organism profile, and clinical findings. The primary outcome was treatment failure based on the Delphi consensus criteria for 1-year follow up. The statistical analysis involved univariate and multivariate regression.ResultsAfter a year of follow-up, the CNPT group had a significantly lower treatment failure rate (25%) compared to the control group (55.3%, p = 0.019). After controlling the confounding factors, the use of CNPT remained as a significant factor with a lower OR (adjusted OR: 0.13; 95% CI 0.02-0.86, p = 0.034), indicating its potential effectiveness in improving DAIR outcomes.ConclusionThe study suggests that CNPT could substantially enhance the success rate of DAIR in treating acute PJI. This intervention may represent a significant advancement in post-operative care, potentially reducing the failure rate of DAIR treatment and improving patient outcomes.
C1 [Alayed, Hisham; Hsu, Allen Herng Shouh; Wu, Kuan-Ting; Wu, Cheng-Ta; Lin, Po-Chun; Kuo, Feng-Chih] Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, 123 Dapi Rd, Kaohsiung 833, Taiwan.
   [Alayed, Hisham] Al Basheer Hosp, Amman, Jordan.
   [Wu, Kuan-Ting; Wu, Cheng-Ta; Kuo, Feng-Chih] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Kuo, Feng-Chih] Cheng Shiu Univ, Ctr Gen Educ, Kaohsiung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Cheng Shiu
   University
RP Kuo, FC (通讯作者)，Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, 123 Dapi Rd, Kaohsiung 833, Taiwan.; Kuo, FC (通讯作者)，Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.; Kuo, FC (通讯作者)，Cheng Shiu Univ, Ctr Gen Educ, Kaohsiung, Taiwan.
EM drhesham87@gmail.com; alking0061@cgmh.org.tw; Ktwu77@gmail.com;
   oliverwu429@cgmh.org.tw; u301117@cgmh.org.tw; fongchikuo@cgmh.org.tw
RI 郭, 峯志/W-3327-2019
FU Kaohsiung Chang Gung Memorial Hospital, Taiwan [CORPG8M0011]
FX We acknowledge and thank the Biostatistics Center at Kaohsiung Chang
   Gung Memorial Hospital and Mr. Chun-Sheng Lin for their statistical
   work. We acknowledge Vanessa Hsieh for her assistance in creating the
   illustration for negative pressure wound therapy. This work was
   partially supported by Kaohsiung Chang Gung Memorial Hospital, Taiwan
   (Grant numbers: CORPG8M0011 to FC Kuo).
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NR 39
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD DEC
PY 2025
VL 20
IS 1
AR 1081
DI 10.1186/s13018-025-06355-1
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA AH1AN
UT WOS:001647979300001
PM 41437388
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nghia, PT
   Son, TT
   Thúy, TTH
   Trong, NH
   Nam, BP
AF Nghia, Phan Tuan
   Thiet Son, Tran
   Thuy, Ta Thi Hong
   Trong, Nguyen Huu
   Nam, Bang Phuong
TI Free Skin Anterolateral Thigh Flap and Vacuum-Assisted Closure Therapy
   for Reconstruction of Snakebite-Induced Complex Hand Defects
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE snakebite; skin necrosis; VAC therapy; ALT flap; hand reconstruction
ID MANAGEMENT
AB Introduction: Cobra (Naja species) envenomation in tropical regions like Vietnam frequently leads to severe hand tissue necrosis, creating complex defects that challenge conventional reconstruction. This study evaluates a staged approach combining vacuumassisted closure (VAC) therapy with free anterolateral thigh (ALT) flap for these challenging injuries. Methods: Eleven patients with extensive hand defects involving skin and/or tendon due to cobra envenomation were included. Following surgical debridement, VAC therapy was applied to prepare the wound bed. Subsequently, definitive reconstruction was performed using tailored ALT flaps, which included fasciocutaneous or thinned configurations depending on defect complexity. Postoperative evaluation included flap viability, range of motion (ROM), and complication assessment. Results: The mean duration of VAC therapy was 11.5 +/- 4.2 days. Eleven ALT flaps with an average dimension of 14.5x7.0 cm were harvested. Flap thinning was performed in eight cases (72.7%), achieving a mean final thickness of 4.6 +/- 1.3 mm. Eight flaps (72.7%) were used to cover defects spanning both digital and dorsal or palmar subunits. Over a mean follow-up of 15.3 months, patients with digital reconstruction achieved a functional ROM at the metacarpophalangeal joint, with 0 degrees of extension and up to 60 degrees of flexion. The main issue was flap bulkiness; no donor-site morbidity was observed. Conclusion: A staged approach combining VAC therapy for wound bed preparation and subsequent reconstruction with a free ALT flap is a safe and effective strategy for managing complex hand defects resulting from cobra bites. This method facilitates optimal wound conditions and provides versatile, well-vascularized tissue coverage, thereby promoting functional hand recovery.
C1 [Nghia, Phan Tuan; Thiet Son, Tran; Thuy, Ta Thi Hong; Nam, Bang Phuong] Hanoi Med Univ, Dept Plast & Reconstruct Surg, 1 Ton That Tung St, Hanoi, Vietnam.
   [Nghia, Phan Tuan; Thiet Son, Tran; Thuy, Ta Thi Hong; Trong, Nguyen Huu] Bach Mai Hosp, Dept Plast Reconstruct & Aesthet Surg, Hanoi, Vietnam.
   [Nghia, Phan Tuan; Thiet Son, Tran; Nam, Bang Phuong] VinUniversity, Vinmec Int Hosp, Dept Plast Reconstruct & Aesthet Surg, Hanoi, Vietnam.
C3 Hanoi Medical University; VinUniversity
RP Nghia, PT (通讯作者)，Hanoi Med Univ, Dept Plast & Reconstruct Surg, 1 Ton That Tung St, Hanoi, Vietnam.
EM phantuannghia@hmu.edu.vn
RI ; Phan Tuấn, Nghĩa/IXN-9615-2023; Thiet Son, Tran/KHV-3202-2024
OI Đặng, Phương Nam/0009-0009-8827-544X; Phan Tuấn,
   Nghĩa/0000-0002-8709-6169; Thiet Son, Tran/0000-0001-6739-1059
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NR 25
TC 0
Z9 0
U1 3
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2025
VL 21
BP 1847
EP 1853
DI 10.2147/TCRM.S560853
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA AL6OH
UT WOS:001651057100001
PM 41477434
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sandberg, JM
   Warner, HL
   Flynn, KJ
   Sexton, SM
   Pham, HT
   Kandler, BW
   Polgreen, PM
   Erickson, BA
AF Sandberg, Jason M.
   Warner, Hayden L.
   Flynn, Kevin J.
   Sexton, Shawn M.
   Pham, Hanh Td
   Kandler, Blaize W.
   Polgreen, Phillip M.
   Erickson, Bradley A.
TI Favorable Outcomes With Early Component Separation, Primary Closure of
   Necrotizing Soft Tissue Infections of the Genitalia (Fournier's
   Gangrene) Debridement Wound Defects
SO UROLOGY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; HYDROSURGICAL DEBRIDEMENT
AB OBJECTIVE To evaluate the efficacy of early necrotizing soft-tissue infections of the genitalia (NSTIG) component separation, primary wound closure (CSC). We hypothesized that early CSC would be safe, decrease the need for split-thickness skin grafting (STSG) and decrease wound convalescence time.
   MATERIALS/METHODS Management of consecutive NSTIG patients from a single institution were evaluated. Three cohorts emerged: 1) those managed/closed by a reconstructive urologist (URO) using CSC principles (wide genital tissue mobilization with primary closure, when possible, +/- STSG), 2) those managed/closed by the general surgery/burn service, and 3) those managed conservatively with secondary closure. Total NSTIG anatomic extent (AE) was determined by assessing involvement of the penis, scrotum, perineum and suprapubic region, and ranged from 1 (<50% involvement of one area) to 8 (>50% involvement in all 4 areas).
   RESULTS Of 84 FG patients meeting study criteria, 48 (57%) were closed primarily and 36 were left to heal by secondary intention. AE was greatest in patients managed by general surgery/burn service (4.5 +/- 1.5), followed by URO (2.7 +/- 1.8) and secondary intention cases (1.3 +/- 0.5). Secondary procedure rates were similar between closure/non-closure cohorts (6.3% v 11%; P = 0.67). STSG use was predicted by wound size (though not time to closure)-specifically with suprapubic and/or penile wounds of >50% involvement. Wound convalescence time decreased by 64% when wounds were closed versus left open, controlling for AE.
   CONCLUSION Early, same-admission primary closure of stable NSTIG wounds is safe and decreases wound convalescence time by over 60%. Published by Elsevier Inc.
C1 Univ Iowa, Carver Coll Med, Dept Urol, Iowa City, IA 52242 USA.
   Univ Iowa, Coll Publ Hlth, Dept Biostat, Iowa City, IA 52242 USA.
   Univ Iowa, Carver Coll Med, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USA.
C3 University of Iowa; University of Iowa; University of Iowa
RP Erickson, BA (通讯作者)，Univ Iowa, Carver Coll Med, Urol Surg, 200 Hawkins Dr,3233 RCP, Iowa City, IA 52242 USA.
EM brad-erickson@uiowa.edu
OI Erickson, Bradley/0000-0001-5237-3464; Polgreen,
   Philip/0000-0002-0630-5898; Pham, Hanh/0000-0002-7502-7369
CR Barham DW, 2019, UROLOGY, V128, pE3, DOI 10.1016/j.urology.2019.02.022
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NR 19
TC 10
Z9 10
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD AUG
PY 2022
VL 166
BP 250
EP 256
DI 10.1016/j.urology.2022.03.042
EA JUL 2022
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 5B3QK
UT WOS:000863487100050
PM 35584736
DA 2026-07-24
ER

PT J
AU Frueh, FS
   Sanchez-Macedo, N
   Calcagni, M
   Giovanoli, P
   Lindenblatt, N
AF Frueh, Florian S.
   Sanchez-Macedo, Nadia
   Calcagni, Maurizio
   Giovanoli, Pietro
   Lindenblatt, Nicole
TI The Crucial Role of Vascularization and Lymphangiogenesis in Skin
   Reconstruction
SO EUROPEAN SURGICAL RESEARCH
LA English
DT Review
DE Angiogenesis; Inosculation; Lymphatic system; Prevascularization; Skin
   graft; Skin substitute; Wound healing
ID VACUUM-ASSISTED CLOSURE; DERMAL REGENERATION; IN-VIVO; VEGF-C; GRAFT
   VASCULATURE; BLOOD-VESSELS; STEM-CELLS; GROWTH; ANGIOGENESIS; THERAPY
AB Background: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician's perspective. Summary: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis. The majority of a graft's microvasculature regresses and is replaced by ingrowing microvessels from the wound bed, finally resulting in a chimeric microvascular network. After inosculation within 48-72 h, the graft is re-oxygenated. In contrast to skin grafts, the vascularization of dermal substitutes is slow and dependent on the ingrowth of vessel-forming angiogenic cells. Preclinical angiogenic strategies with adipose tissue-derived isolates are appealing for the treatment of difficult wounds and may markedly accelerate skin reconstruction in the future. However, their translation from bench to bedside is still restricted by major regulatory restrictions. Finally, the lymphatic system contributes to edema reduction and the removal of local wound debris. Therapeutic lymphangiogenesis is an emerging field of research in skin reconstruction. Key Messages: For the successful engraftment of skin grafts and dermal substitutes, the rapid formation of a microvascular network is of pivotal importance. Hence, to understand the biological processes behind revascularization of skin substitutes and to implement this knowledge into clinical practice is a prerequisite when treating skin defects. Furthermore, a functional lymphatic drainage crucially contributes to the engraftment of skin substitutes. (C) 2018 S. Karger AG, Basel
C1 [Frueh, Florian S.; Sanchez-Macedo, Nadia; Calcagni, Maurizio; Giovanoli, Pietro; Lindenblatt, Nicole] Univ Zurich, Univ Hosp Zurich, Div Plast Surg & Hand Surg, Zurich, Switzerland.
   [Sanchez-Macedo, Nadia] Univ Zurich, Univ Hosp Zurich, Div Surg Res, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Frueh, FS (通讯作者)，Univ Hosp Zurich, Div Plast Surg & Hand Surg, Ramistr 100, CH-8091 Zurich, Switzerland.
EM florian.frueh@usz.ch
RI Frueh, Florian S/R-5012-2019; Lindenblatt, Nicole/O-6708-2016; Calcagni,
   Maurizio/C-9769-2012
OI Frueh, Florian S/0000-0003-0904-9591; Lindenblatt,
   Nicole/0000-0003-0293-1004; Sanchez-Macedo, Nadia/0000-0002-6629-5900;
   Calcagni, Maurizio/0000-0003-4372-0561
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NR 70
TC 45
Z9 48
U1 1
U2 26
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0014-312X
EI 1421-9921
J9 EUR SURG RES
JI Eur. Surg. Res.
PY 2018
VL 59
IS 3-4
BP 242
EP 254
DI 10.1159/000492413
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HA9UD
UT WOS:000450651700005
PM 30244256
DA 2026-07-24
ER

PT J
AU Shuto, K
   Kono, T
   Akutsu, Y
   Uesato, M
   Mori, M
   Matsuo, K
   Kosugi, C
   Hirano, A
   Tanaka, K
   Okazumi, S
   Koda, K
   Matsubara, H
AF Shuto, Kiyohiko
   Kono, Tsuguaki
   Akutsu, Yasunori
   Uesato, Masaya
   Mori, Mikito
   Matsuo, Kenichi
   Kosugi, Chihiro
   Hirano, Atsushi
   Tanaka, Kuniya
   Okazumi, Shinich
   Koda, Keiji
   Matsubara, Hisahiro
TI Naso-esophageal extraluminal drainage for postoperative anastomotic leak
   after thoracic esophagectomy for patients with esophageal cancer
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leak; drainage; esophageal neoplasms
ID VACUUM-ASSISTED CLOSURE; RETROSPECTIVE ANALYSIS; MANAGEMENT; CARCINOMA;
   MORBIDITY; MORTALITY; SURVIVAL; SURGERY
AB Postoperative anastomotic leaks and subsequent mediastinal abscess are serious complications. The purpose of this study was to assess the efficacy of naso-esophageal extraluminal drainage after thoracic esophagectomy with gastric conduit reconstruction using a posterior mediastinal route. About 50 of 365 patients (13.7%) with esophageal cancer and postoperative anastomotic leak after curative esophagectomy was investigated. Beginning in June 2009, naso-esophageal extraluminal drainage by inserting a naso-esophageal aspiration tube into the abscess cavity when percutaneous abscess drainage was introduced which was ineffective or technically impossible. Twenty-five patients underwent naso-esophageal extraluminal drainage concomitantly with enteral nutrition. Twenty-one (84%) patients had major leaks, one (4%) minor leak and three (12%) had endoscopically proven conduit necrosis. None of the naso-esophageal extraluminal drainage cases (100%) required reintervention or reoperation and all experienced complete cure (100%) during hospitalization. Endoscopic balloon dilatation was performed for four patients after discharge because of anastomotic stricture. Patients with leaks were divided into two groups: current group (n = 32), treated after June 2009, and preceding group (n = 18), treated prior to the introduction of naso-esophageal extraluminal drainage. Significantly more patients in the preceding group suffered respiratory failure (28% vs. 61%, p = 0.024), and higher reoperation rate (0% vs. 17%, p = 0.042) and hospital mortality (0% vs. 22%, p = 0.013). In the current group, 31 (97%) patients experienced complete cure during hospitalization. Naso-esophageal extraluminal drainage and concomitant enteral nutritional support are less invasive, and effective and powerful methods to treat even major leakage after esophagectomy. These methods may be an alternative management to improve mortality for patients with esophageal cancer.
C1 [Shuto, Kiyohiko; Uesato, Masaya; Mori, Mikito; Matsuo, Kenichi; Kosugi, Chihiro; Hirano, Atsushi; Tanaka, Kuniya; Koda, Keiji] Teikyo Univ, Chiba Med Ctr, Dept Surg, 3426-3 Anesaki, Ichihara, Chiba 2990111, Japan.
   [Shuto, Kiyohiko; Kono, Tsuguaki; Akutsu, Yasunori; Matsubara, Hisahiro] Chiba Univ, Grad Sch Med, Dept Frontier Surg, Chiba, Japan.
   [Okazumi, Shinich] Toho Univ, Sakura Med Ctr, Dept Surg, Sakura, Japan.
C3 Teikyo University; Chiba University; Toho University
RP Shuto, K (通讯作者)，Teikyo Univ, Chiba Med Ctr, Dept Surg, 3426-3 Anesaki, Ichihara, Chiba 2990111, Japan.
EM kshuto@med.teikyo-u.ac.jp
RI Okazumi, Shinichi/JXM-6209-2024
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NR 20
TC 15
Z9 21
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAR
PY 2017
VL 30
IS 3
DI 10.1111/dote.12492
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EY8TY
UT WOS:000404271900013
PM 27862613
DA 2026-07-24
ER

PT J
AU Suarez-Grau, JM
   Jurado, JFG
   Menchero, JG
   Luque, JAB
AF Manuel Suarez-Grau, Juan
   Guadalajara Jurado, Juan Francisco
   Gomez Menchero, Julio
   Bellido Luque, Juan Antonio
TI Delayed primary closure in open abdomen with stoma using dynamic closure
   system
SO SPRINGERPLUS
LA English
DT Article
DE Open abdomen; Surgery; ABRA; VAC; Abdominal wall; Closure;
   Compartimental syndrome
ID WOUND CLOSURE
AB Background: The situation of abdominal sepsis secondary to colonic perforation sometimes forces treat the patient with multiple interventions in the open abdomen (OA) context. Correct management of OA is important to restore the patient's clinical situation and to avoid further complications of the abdominal wall. Delayed primary closure of the abdomen using a dynamic and progressive traction is a relatively new technique for treating the OA.
   Case presentation: We report the case of a 50 year old woman with history of malnutrition and chronic obstructive pulmonary disease, affects for an OA after several surgical interventions. Two previous interventions (right colectomy, ileostomy and laparotomy with Bogota bag) for disseminated peritonitis and abdominal compartment syndrome were performed. Six days after the Bogota bag the of the dynamic closure system ABRA (R) system was placed to delayed primary closure of the abdomen with excellent result results of the contingency of the abdominal wall.
   Discussion: The most common technique in the current management of OA is the placement of vacuum-assisted closure or the use of a mesh. These systems generally require several operations to restore the integrity of the abdominal wall. However, the dynamic closure of the abdominal wall makes it possible to restore it into the same process.
   Conclusions: ABRA system allows delayed primary closure of the abdominal wall in an OA by sepsis secondary to colonic perforation. The stoma was not a problem with this technique. The final closure of the abdomen was at 16 days after the ABRA placement. The abdominal wall has not alterations in the follow up after 3 years.
C1 [Manuel Suarez-Grau, Juan; Guadalajara Jurado, Juan Francisco; Gomez Menchero, Julio; Bellido Luque, Juan Antonio] Gen Hosp Riotinto, Minas De Riotinto, Huelva, Spain.
RP Suarez-Grau, JM (通讯作者)，Gen Hosp Riotinto, Minas De Riotinto, Huelva, Spain.
EM graugrau@gmail.com
RI Suarez Grau, Juan Manuel/AAU-8685-2021; /G-4670-2015
OI Suarez Grau, Juan Manuel/0000-0002-2937-7683; 
CR [Anonymous], 2000, ACTA CHIRURG AUSTRIA
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NR 12
TC 1
Z9 2
U1 0
U2 5
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD SEP 17
PY 2015
VL 4
AR 519
DI 10.1186/s40064-015-1316-9
PG 4
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR4KJ
UT WOS:000361300600021
PM 26405639
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU O'Donohoe, PK
   Leon, R
   Orr, DJA
   de Blacam, C
AF O'Donohoe, Patrick K.
   Leon, Ryan
   Orr, David J. A.
   de Blacam, Catherine
TI Safety of Silver Dressings in Infants; a Systematic Scoping Review
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
DE silver-based dressing; silver; infant; wound; burn
ID PARTIAL THICKNESS BURNS; VACUUM-ASSISTED CLOSURE;
   APLASIA-CUTIS-CONGENITA; NANOCRYSTALLINE SILVER; GIANT OMPHALOCELE;
   NONOPERATIVE MANAGEMENT; NECROTIZING FASCIITIS; PEDIATRIC-PATIENTS;
   WOUND MANAGEMENT; CERIUM NITRATE
AB Silver-based dressings are used to reduce infection risk and optimize conditions for wound healing. They are widely used in the management of burns and other complex wounds. However, reports of elevated serum silver and concern over systemic toxicity have meant that their use in young children has been questioned. The aim of the current study was to map the literature relating to the use of silver-based dressings in children under 1 year of age. A systematic scoping review was conducted according to the methodology described by the Joanna Briggs Institute. Sources were identified from major medical databases as well as the gray literature. Inclusion criteria were the use of silver-based dressing in children under 1 year of age. Outcomes of interest were complications or adverse events attributed to silver-based dressings and elevated serum silver levels. A total of 599 sources were identified through the search strategy, with 110 included for review. Complications were described in 31 sources, with the most frequent being wound infection. No cases of argyria, kernicterus, or methemoglobinemia were reported. Six sources documented elevated serum silver levels in infants but none reported adverse events related to this. On the basis of current evidence, we suggest reserving silver dressings in infants under 1 for wounds that are at high risk of infection. Wound area and duration of treatment should be considered when assessing the risk of systemic absorption of silver. Standardized data collection and recording of complications and adverse events is recommended to better inform future clinical decision-making.
C1 [O'Donohoe, Patrick K.; Leon, Ryan; Orr, David J. A.; de Blacam, Catherine] Childrens Hlth Ireland Crumlin, Dept Plast Surg, Dublin, Ireland.
   [O'Donohoe, Patrick K.; Orr, David J. A.; de Blacam, Catherine] Royal Coll Surgeons Ireland, Dept Surg, Dublin, Ireland.
   [Orr, David J. A.; de Blacam, Catherine] Trinity Coll Dublin, Dept Paediat, Dublin, Ireland.
   [Orr, David J. A.] Trinity Coll Dublin, Dept Surg, Dublin, Ireland.
C3 Royal College of Surgeons in Ireland - RCSI; Trinity College Dublin;
   Trinity College Dublin
RP de Blacam, C (通讯作者)，Childrens Hlth Ireland Crumlin, Dept Plast Surg, Dublin, Ireland.; de Blacam, C (通讯作者)，Royal Coll Surgeons Ireland, Dept Surg, Dublin, Ireland.; de Blacam, C (通讯作者)，Trinity Coll Dublin, Dept Paediat, Dublin, Ireland.
EM catherinedeblacam@rcsi.ie
RI de Blacam, Catherine/F-6589-2015; Orr, David/T-1779-2019
OI de Blacam, Catherine/0000-0002-3197-4161; O'Donohoe,
   Patrick/0000-0002-7323-1454; Orr, David/0000-0002-1935-1412
FX The authors gratefully acknowledge the support of Breffni Smith,
   Clinical Librarian at the Royal College of Surgeons in Ireland for
   assistance in developing search strategies for the scoping review. This
   article was presented at the European Club for Paediatric Burns World
   Congress in Toronto Canada in September 2023.
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NR 139
TC 1
Z9 2
U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2025
VL 46
IS 2
BP 349
EP 360
DI 10.1093/jbcr/irae159
EA SEP 2024
PG 12
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 5LH4I
UT WOS:001316165400001
PM 39165069
DA 2026-07-24
ER

PT J
AU Landoni, G
   Lomivorotov, V
   Silvietti, S
   Neto, CN
   Pisano, A
   Alvaro, G
   Hajjar, LA
   Paternoster, G
   Riha, H
   Monaco, F
   Szekely, A
   Lembo, R
   Asian, NA
   Affronti, G
   Likhvantsev, V
   Amarelli, C
   Fominskiy, E
   Redaelli, MB
   Putzu, A
   Baiocchi, M
   Ma, J
   Bono, G
   Camarda, V
   Covello, RD
   Di Tomasso, N
   Labonia, M
   Leggieri, C
   Lobreglio, R
   Monti, G
   Mura, P
   Scandroglio, AM
   Pasero, D
   Turi, S
   Roasio, A
   Votta, CD
   Saporito, E
   Riefolo, C
   Sartini, C
   Brazzi, L
   Bellomo, R
   Zangrillo, A
AF Landoni, Giovanni
   Lomivorotov, Vladimir
   Silvietti, Simona
   Neto, Caetanor Nigro
   Pisano, Antonio
   Alvaro, Gabriele
   Hajjar, Ludmilla Abrahao
   Paternoster, Gianluca
   Riha, Hynek
   Monaco, Fabrizio
   Szekely, Andrea
   Lembo, Rosalba
   Asian, Nesrin A.
   Affronti, Giovanni
   Likhvantsev, Valery
   Amarelli, Cristiano
   Fominskiy, Evgeny
   Redaelli, Martina Baiardo
   Putzu, Alessandro
   Baiocchi, Massimo
   Ma, Jun
   Bono, Giuseppe
   Camarda, Valentina
   Covello, Remo Daniel
   Di Tomasso, Nora
   Labonia, Miriam
   Leggieri, Carlo
   Lobreglio, Rosetta
   Monti, Giacomo
   Mura, Paolo
   Scandroglio, Anna Mara
   Pasero, Daniela
   Turi, Stefano
   Roasio, Agostino
   Votta, Carmine D.
   Saporito, Emanuela
   Riefolo, Claudio
   Sartini, Chiara
   Brazzi, Luca
   Bellomo, Rinaldo
   Zangrillo, Alberto
TI Nonsurgical Strategies to Reduce Mortality in Patients Undergoing
   Cardiac Surgery: An Updated Consensus Process
SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
LA English
DT Article
DE cardiac surgery; perioperative; consensus; mortality; mortality
   reduction; review
ID INTRAAORTIC BALLOON PUMP; ACUTE KIDNEY INJURY; RANDOMIZED
   CONTROLLED-TRIAL; POSTOPERATIVE COMPLICATIONS; BYPASS SURGERY;
   INTENSIVE-CARE; LEVOSIMENDAN; METAANALYSIS; SURVIVAL; MULTICENTER
AB Objective: A careful choice of perioperative care strategies is pivotal to improve survival in cardiac surgery. However, there is no general agreement or particular attention to which nonsurgical interventions can reduce mortality in this setting. The authors sought to address this issue with a consensus-based approach.
   Design: A systematic review of the literature followed by a consensus-based voting process.
   Setting: A web-based international consensus conference.
   Participants: More than 400 physicians from 52 countries participated in this web-based consensus conference.
   Interventions: The authors identified all studies published in peer-reviewed journals that reported on interventions with a statistically significant effect on mortality in the setting of cardiac surgery through a systematic Medline/PubMed search and contacts with experts. These studies were discussed during a consensus meeting and those considered eligible for inclusion in this study were voted on by clinicians worldwide.
   Measurements and Main Results: Eleven interventions finally were selected: 10 were shown to reduce mortality (aspirin, glycemic control, high volume surgeons, prophylactic intra-aortic balloon pump, levosimendan, leuko-depleted red blood cells transfusion, noninvasive ventilation, tranexamic acid, vacuum-assisted closure, and volatile agents), whereas 1 (aprotinin) increased mortality. A significant difference in the percentages of agreement among different countries and a variable gap between agreement and clinical practice were found for most of the interventions.
   Conclusions: This updated consensus process identified 11 nonsurgical interventions with possible survival implications for patients undergoing cardiac surgery. This list of interventions may help cardiac anesthesiologists and intensivists worldwide in their daily clinical practice and can contribute to direct future research in the field. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Landoni, Giovanni; Silvietti, Simona; Monaco, Fabrizio; Lembo, Rosalba; Affronti, Giovanni; Redaelli, Martina Baiardo; Camarda, Valentina; Di Tomasso, Nora; Leggieri, Carlo; Monti, Giacomo; Scandroglio, Anna Mara; Turi, Stefano; Votta, Carmine D.; Riefolo, Claudio; Sartini, Chiara; Zangrillo, Alberto] IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Milan, Italy.
   [Landoni, Giovanni; Zangrillo, Alberto] Univ Vita Salute San Raffaele, Milan, Italy.
   [Lomivorotov, Vladimir; Fominskiy, Evgeny] Minist Hlth, Siberian Biomed Res Ctr, Dept Anaesthesiol & Intens Care, Novosibirsk, Russia.
   [Neto, Caetanor Nigro] Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
   [Pisano, Antonio] Monaldi Hosp, Azienda Osped Colli, Div Cardiac Anesthesia & Intens Care, Naples, Italy.
   [Alvaro, Gabriele; Labonia, Miriam] Policlin Univ Mater Domini, Dept Anesthesia & Intens Care, Catanzaro, Italy.
   [Hajjar, Ludmilla Abrahao] Univ Sao Paulo, InCor, Dept Cardiopneumol, Surg Intens Care, Sao Paulo, Brazil.
   [Paternoster, Gianluca] Osped San Carlo Borromeo Milano, Dept Cardiovasc Anaesthesia & Intens Care, Potenza, Italy.
   [Riha, Hynek] Inst Clin & Expt Med, Dept Anaesthesiol & Intens Care Med, Cardiothorac Anaesthesiol & Intens Care, Prague, Czech Republic.
   [Szekely, Andrea] Semmelweis Egyet, Dept Anesthesia & Intens Care, Budapest, Hungary.
   [Asian, Nesrin A.] Medipol Mega Univ Hosp, Dept Anesthesiol & Intens Care, Istanbul, Turkey.
   [Likhvantsev, Valery] Moscow Reg Clin & Res Inst, Dept Anesthesia & Intens Care, Moscow, Russia.
   [Amarelli, Cristiano] Monaldi Hosp, Dept Cardiovasc Surg & Transplants, Naples, Italy.
   [Putzu, Alessandro] Cardioctr Ticino, Dept Cardiovasc Anesthesia & Intens Care, Lugano, Switzerland.
   [Baiocchi, Massimo] S Orsola Malpighi Univ Hosp, Dept Anesthesia & Intens Care, Bologna, Italy.
   [Ma, Jun] Capital Med Univ, Beijing Anzhen Hosp, Ctr Anesthesiol, Beijing, Peoples R China.
   [Bono, Giuseppe; Saporito, Emanuela] Policlin Univ Mater Domini, Dept Anesthesia & Intens Care, Catanzaro, Italy.
   [Covello, Remo Daniel] ASST Valle Olona, Busto Arsizio Hosp, Anesthesia & Intens Care Unit, Varese, Italy.
   [Lobreglio, Rosetta; Pasero, Daniela; Brazzi, Luca] AOU Citta Salute & Sci, Dept Anesthesia & Intens Care, Turin, Italy.
   [Mura, Paolo] Policlin Duilio Casula AOU Cagliari, Dept Med Sci M Aresu, Dept Anesthesia, Cagliari, Italy.
   [Mura, Paolo] Policlin Duilio Casula AOU Cagliari, Dept Med Sci M Aresu, Intens Care Unit, Cagliari, Italy.
   [Roasio, Agostino] Osped Cardinal Massaia di Asti, Dept Anaesthesia & Intens Care, Asti, Italy.
   [Bellomo, Rinaldo] Univ Melbourne, Sch Med, Melbourne, Vic, Australia.
   [Brazzi, Luca] Univ Turin, Dept Surg Sci, Turin, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; Ministry of Health of the Russian
   Federation; Meshalkin National Medical Research Center; Instituto Dante
   Pazzanese de Cardiologia; Universidade de Sao Paulo; San Carlo Borromeo
   Hospital; Institute for Clinical & Experimental Medicine (IKEM);
   Semmelweis University; Istanbul Medipol University; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna; Capital Medical University;
   Ospedale di Busto Arsizio; A.O.U. Citta della Salute e della Scienza di
   Torino; University of Melbourne; University of Turin
RP Landoni, G (通讯作者)，IRCCS San Raffaele Sci Inst, Dept Anesthesia & Intens Care, Via Olgettina 60, I-20132 Milan, Italy.
EM landoni.giovanni@hsr.it
RI COVELLO, Remo Daniel/MIK-2019-2025; Monaco, Fabrizio/GZA-9167-2022;
   Sartini, Chiara/HGU-3723-2022; ZANGRILLO, Alberto/AAH-2037-2019;
   Likhvantsev, Valery/A-4893-2016; Amarelli, Cristiano/U-6804-2017;
   Székely, Andrea/AAD-9724-2020; Nigro Neto, Caetano/M-4649-2016; Brazzi,
   Luca/AAS-4978-2020; Baiocchi, Massimo/JLM-6794-2023; Di Tomasso,
   Nora/ABD-7006-2020; LANDONI, Giovanni/AAH-1881-2019; Abrahão Hajjar,
   Ludhmila/HKO-6270-2023; Saporito, Emanuela/AAH-5739-2021; Lomivorotov,
   Vladimir/L-7868-2014; turi, stefano/AAC-2115-2019; Monti,
   Giacomo/AAN-2213-2020; Riha, Hynek/AGT-5807-2022; Aslan, Nesrin
   Ahu/HJO-9019-2023; Fominskiy, Evgeny/D-9118-2014; Putzu,
   Alessandro/AAY-3754-2020; Pisano, Antonio/AAG-1028-2020; Bellomo,
   Rinaldo/F-2571-2011; pasero, daniela cristina/ABF-4731-2021; Roasio,
   Agostino/HLG-5137-2023
OI COVELLO, Remo Daniel/0000-0002-6696-5361; Monaco,
   Fabrizio/0000-0001-5186-1976; Sartini, Chiara/0000-0003-2053-8636;
   Camarda, Valentina/0000-0002-7082-7113; ZANGRILLO,
   Alberto/0000-0002-7687-7648; Likhvantsev, Valery/0000-0002-5442-6950;
   Amarelli, Cristiano/0000-0002-7949-7771; Nigro Neto,
   Caetano/0000-0001-8134-3440; Brazzi, Luca/0000-0001-7059-0622; Baiocchi,
   Massimo/0000-0001-7909-6399; Di Tomasso, Nora/0000-0001-5706-8928;
   LANDONI, Giovanni/0000-0002-8594-5980; Abrahão Hajjar,
   Ludhmila/0000-0001-5645-2055; Saporito, Emanuela/0000-0002-6200-2365;
   PATERNOSTER, GIANLUCA/0000-0002-4032-0821; Votta,
   Carmine/0000-0002-7408-9605; Lomivorotov, Vladimir/0000-0001-8591-6461;
   turi, stefano/0000-0001-7365-3510; LEGGIERI, Carlo/0000-0002-0910-889X;
   Monti, Giacomo/0000-0002-3885-9238; Riha, Hynek/0000-0002-9861-7361;
   Baiardo Redaelli, Martina/0000-0002-4232-1713; Fominskiy,
   Evgeny/0000-0002-3198-4458; Putzu, Alessandro/0000-0002-4943-450X;
   Pisano, Antonio/0000-0002-5118-444X; 
FU Orion Pharma; AbbVie; Pall; Tenax
FX M. Baiocchi, V. Lomivorotov, G. Monti, G. Paternoster, and H. Riha have
   received speaker fees from Orion Pharma, and G. Landoni has received
   speaker fees from AbbVie, Orion Pharma, Pall, and Tenax.
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NR 58
TC 35
Z9 40
U1 0
U2 19
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1053-0770
EI 1532-8422
J9 J CARDIOTHOR VASC AN
JI J. Cardiothorac. Vasc. Anesth.
PD FEB
PY 2018
VL 32
IS 1
BP 225
EP 235
DI 10.1053/j.jvca.2017.06.017
PG 11
WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System;
   Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System
GA FV6ZG
UT WOS:000424730300030
PM 29122431
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Garcia-Ruano, A
   Deleyto, E
   Garcia-Fernandez, S
AF Garcia-Ruano, Angela
   Deleyto, Esther
   Garcia-Fernandez, Sebastian
TI VAC-instillation therapy in abdominal mesh exposure: a novel indication
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Instillation; Mesh; Abdominal; Vacuum
ID PRESSURE WOUND THERAPY; ASSISTED CLOSURE; MANAGEMENT; DEHISCENCE;
   EFFICACY
AB Background: Defects of the abdominal wall pose a problem for general surgeons that negatively affects patient prognosis. In cases of abdominal wall wound dehiscence and exposed abdominal mesh, conservative treatment has not been proven effective to date. We aimed to study patient outcomes in cases of abdominal wall wound dehiscence with mesh exposure treated with vacuum-assisted closure system with intermittent instillation (VAC-instillation) as a temporary cover to achieve wound closure.
   Methods: A retrospective cohort study was performed to evaluate and compare the outcomes of 45 patients with postoperative abdominal wall wound dehiscence and exposed mesh: 34 were treated with conventional dressings and 11 with the VAC-instillation device. Clinical records were reviewed, and patient demographics, indication for abdominal surgery, and existing risk factors were noted. Patient outcome was evaluated in terms of number of reoperations, length of hospital stay, and total time of treatment.
   Results: Demographic features did not differ significantly between the two groups. Patients treated with conventional dressings required a significantly higher number of surgeries to achieve wound closure. We did not find statistical differences between the two groups regarding length of hospital stay, but the VAC-instillation group showed a significantly shorter total time of treatment. The incidence of complications was lower in the VAC-instillation group, though hernia recurrence rate was slightly higher in these patients.
   Conclusions: VAC-instillation is a valid option for the conservative treatment of critical patients with abdominal wall wound dehiscence and exposed infected mesh that allows recovery with fewer surgeries and complications and avoids the need of mesh removal. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Garcia-Ruano, Angela; Deleyto, Esther] Univ Hosp Gregorio Maranon, Dept Plast Aesthet & Reconstruct Surg, Madrid, Spain.
   [Garcia-Fernandez, Sebastian] Univ Hosp Virgen Macarena, Dept Gen Surg, Seville, Spain.
C3 General University Gregorio Maranon Hospital; University of Sevilla;
   Hospital Universitario Virgen Macarena; Virgen del Rocio University
   Hospital
RP Garcia-Ruano, A (通讯作者)，C Gustavo Bacarisas 2,6 B, Seville 41010, Spain.
EM dra.angelagr@gmail.com
OI Deleyto, Esther/0000-0002-8289-2748
CR Berrevoet F, 2013, HERNIA, V17, P67, DOI 10.1007/s10029-012-0969-3
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NR 29
TC 15
Z9 17
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2016
VL 206
IS 2
BP 292
EP 297
DI 10.1016/j.jss.2016.08.030
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EC2VY
UT WOS:000387983600005
PM 27884322
DA 2026-07-24
ER

PT J
AU Cantero, R
   Rubio-Perez, I
   Leon, M
   Alvarez, M
   Diaz, B
   Herrera, A
   Diaz-Dominguez, J
   Rodriguez-Montes, JA
AF Cantero, Ramon
   Rubio-Perez, Ines
   Leon, Miguel
   Alvarez, Mario
   Diaz, Beatriz
   Herrera, Ana
   Diaz-Dominguez, Joaquin
   Rodriguez-Montes, Jose Antonio
TI Negative-Pressure Therapy to Reduce the Risk of Wound Infection
   Following Diverting Loop Ileostomy Reversal: An Initial Study
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE surgical infections; negative-pressure therapy; Prevena; wound care;
   ileostomy closure wounds
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; INCISION
   MANAGEMENT-SYSTEM; PREVENTION; SURGERY; STOMA; EXPERIENCE
AB OBJECTIVE:
   To evaluate if the application of a negative-pressure therapy system (Prevena Incision Management System, Kinetics Concepts Inc, [KCI] an Acelity Company, San Antonio, Texas) on ileostomy-closure surgical wounds would reduce surgical site infections (SSIs) in comparison with conventional closure and dressing.
   DESIGN:
   Prospective interventional pilot study.
   SETTING:
   La Paz University Hospital, tertiary care academic hospital in Madrid, Spain.
   PATIENTS:
   The Prevena device was applied on the wounds of 17 consecutive patients undergoing ileostomy reversal. Control subjects were 43 patients undergoing the same procedure, in which conventional dressings were used for the wound.
   INTERVENTION:
   The device was applied on the wound immediately after surgery (under sterile conditions) and maintained for 5 to 7 days. Patients were evaluated daily, and on the seventh postoperative day, the device was removed and wounds carefully inspected. Another evaluation was performed a month after the surgical intervention in the outpatient clinic.
   MAIN OUTCOME MEASURE:
   The primary end point of the study was the detection of SSI (defined according to the Centers for Disease Control and Prevention definitions). Other intervention-related complications were also registered.
   MAIN RESULTS:
   There were no significant differences in demographic variables between groups. In the control group, 9 patients (21%) presented SSI, with statistical significance (P < .038) when compared with the intervention group (0%). There were no complications associated with the application of the Prevena device. Other complications (for example, ileus or obstruction) occurred in 30% of patients.
   CONCLUSIONS:
   The negative-pressure Prevena System was safe and easy to use and may prevent SSIs in dirty wounds, such as those from ileostomy closure.
C1 [Cantero, Ramon; Rubio-Perez, Ines; Leon, Miguel; Alvarez, Mario; Diaz, Beatriz; Herrera, Ana; Diaz-Dominguez, Joaquin; Rodriguez-Montes, Jose Antonio] La Paz Univ Hosp, Gen & Digest Surg Dept, Madrid, Spain.
C3 Hospital Universitario La Paz
RP Cantero, R (通讯作者)，La Paz Univ Hosp, Gen & Digest Surg Dept, Madrid, Spain.
RI Cantero, Ramon/JTV-4751-2023
OI Rubio-Perez, Ines/0000-0002-3960-6865
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NR 24
TC 30
Z9 35
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2016
VL 29
IS 3
BP 114
EP 118
DI 10.1097/01.ASW.0000480458.60005.34
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DE6EH
UT WOS:000370726000001
PM 26866867
OA hybrid
DA 2026-07-24
ER

PT J
AU Ou, QF
   Dou, XL
   Wu, PF
   Zhou, ZB
   Pan, D
   Tang, JY
AF Ou, Qifeng
   Dou, Xiaolin
   Wu, Panfeng
   Zhou, Zhengbing
   Pan, Ding
   Tang, Ju-yu
TI Regionalized coverage of the totally degloved foot by a combination of
   ?Boat sock? style free flap and skin graft
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Foot; Degloving injury; Flap; Skin graft; Regionalized coverage
ID ANTEROLATERAL THIGH FLAP; VACUUM-ASSISTED CLOSURE; RECONSTRUCTION;
   INJURIES; SOLE; EXPERIENCE; MANAGEMENT; DEFECTS
AB Introduction: To maximize the morpho-functional recovery on the totally degloved foot while not excessively introducing the technical complexity of microsurgery, we present a regionalized reconstruction, in which the highly functional subunit (weight-bearing area and ankle-around area) is covered by free skin flaps, and the less functional subunit (dorsum) by skin graft. Methods: From June 2011 to December 2017, 10 patients who had total degloving injury on foot underwent reconstruction based on regionalized coverage. As the shape of combined flaps resemble a boat sock in high-heeled shoe, we name it as "Boat Sock" flaps. Complication like vascular compromise, partial or total flap loss, Equinus deformity and delayed plantar ulceration were documented elaborately. Secondary surgeries were also recorded. Foot function was evaluated by Maryland foot score at the last follow up. Results: Twenty-one free skin flaps were used for "Boat sock" coverage on highly functional subunits. Flap dimension ranged from 19 x5cm 2 to 28 x8cm 2 (mean 151cm 2 ). Among these flaps, one experienced partial necrosis which was treated conservatively, one experienced burn due to lack of protective sensation. Complication like Equinus deformity or delayed plantar ulceration did not occur. Secondary surgery included debulking on two cases. Mean Maryland foot score was 90.4. Conclusion: This regionalized coverage by "Boat Sock" flaps and skin graft could serve as a standard procedure for reconstruction of the totally degloved foot, by offering the benefits of multi-plane coverage, a well-contoured ankle, an abrasion-tolerant planta, and eclectic surgical complexities. (c) 2022 Elsevier Ltd. All rights reserved.
C1 [Ou, Qifeng; Wu, Panfeng; Zhou, Zhengbing; Pan, Ding; Tang, Ju-yu] Cent South Univ, Xiangya Hosp, Dept Orthoped Hand & Microsurg, Changsha, Peoples R China.
   [Dou, Xiaolin] Cent South Univ, Xiangya Hosp, Dept Gen Surg, Changsha, Peoples R China.
C3 Central South University; Central South University
RP Tang, JY (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Orthoped Hand & Microsurg, Changsha, Peoples R China.
EM tangjuyu@csu.edu.cn
RI Tang, Juyu/ABA-5676-2020
FU National Natural Sci-ence Foundation of China [81871577]
FX This publication was funded in part by the National Natural Sci-ence
   Foundation of China (81871577 by Dr. Juyu Tang) , The study sponsor had
   no involvement in the study design, collection, analy-sis, and
   interpretation of data, writing of the manuscript, and de-cision to
   submit the manuscript for publication.
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NR 20
TC 1
Z9 1
U1 1
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUN
PY 2022
VL 53
IS 6
BP 2333
EP 2339
DI 10.1016/j.injury.2022.02.015
EA MAY 2022
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 1X2DW
UT WOS:000807271400043
PM 35190183
DA 2026-07-24
ER

PT J
AU Bartoletti, M
   Mikus, E
   Pascale, R
   Giannella, M
   Tedeschi, S
   Calvi, S
   Tenti, E
   Tumietto, F
   Viale, P
AF Bartoletti, Michele
   Mikus, Elisa
   Pascale, Renato
   Giannella, Maddalena
   Tedeschi, Sara
   Calvi, Simone
   Tenti, Elena
   Tumietto, Fabio
   Viale, Pierluigi
TI Clinical experience with dalbavancin for the treatment of deep sternal
   wound infection
SO JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
LA English
DT Article
DE Dalbavancin; Cardiac surgery; Deep sternal wound infection;
   Mediastinitis
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; RISK-FACTORS;
   THERAPY; EFFICACY; SKIN
AB Objectives: Deep sternal wound infection (DSWI) is a complication of major heart surgery with high morbidity as well as prolonged antimicrobial treatment and hospital length of stay (LoS). Dalbavancin is a new lipoglycopeptide antibiotic active against Gram-positive micro-organisms, including methicillin-resistant Staphylococcus aureus (MRSA), with a long half-life. This small case series assessed the feasibility of dalbavancin for the treatment of DSWI.
   Methods: This was retrospective, observational, cohort study of patients treated with dalbavancin for DSWI over a 2-year period (March 2016 to April 2018) in two cardiac surgery departments in Italy. All patients with DSWI underwent surgical accurate debridement. Dalbavancin was administered during the hospital stay or in an outpatient facility.
   Results: Among 15 patients enrolled in the study, MRSA was isolated in 7 (47%), methicillin-resistant Staphylococcus epidermidis in 6 (40%) and other coagulase-negative staphylococci in 2 (13%). Dalbavancin was administered by two infusions in 9 patients (60%), whereas 5 patients (33%) received a median of four doses. Fourteen patients received a first dose of 1000 mg followed by 500 mg, whereas one patient received two doses of 1500 mg each. All patients were defined as clinically cured. The median hospital LoS was 13 days (interquartile range, 8-18 days). At 6 months after discharge, 14 patients (93%) showed no relapse of DSWI, whereas 1 patient recurred with a diagnosis of DSWI caused by another pathogen (Candida sp.).
   Conclusion: Dalbavancin may be an alternative option for DSWI caused by Gram-positive bacteria when first-line treatments are contraindicated or as salvage treatment. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.
C1 [Bartoletti, Michele; Pascale, Renato; Giannella, Maddalena; Tedeschi, Sara; Tumietto, Fabio; Viale, Pierluigi] Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Infect Dis Unit, Via Massarenti 9, I-40138 Bologna, Italy.
   [Mikus, Elisa; Calvi, Simone] Maria Cecilia Hosp, GVM Care & Res, Cardiothorac & Vasc Dept, Cotignola, RA, Italy.
   [Tenti, Elena] Maria Cecilia Hosp, GVM Care & Res, Clin Trial Unit, Cotignola, RA, Italy.
   [Bartoletti, Michele] St Orsola Marcello Malpighi Hosp, Infect Dis Unit, Via Massarenti 11, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna; Maria Cecilia Hospital; Maria Cecilia Hospital; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna
RP Bartoletti, M (通讯作者)，Univ Bologna, St Orsola Malpighi Hosp, Dept Med & Surg Sci, Infect Dis Unit, Via Massarenti 9, I-40138 Bologna, Italy.; Bartoletti, M (通讯作者)，St Orsola Marcello Malpighi Hosp, Infect Dis Unit, Via Massarenti 11, I-40138 Bologna, Italy.
EM michele.bartoletti4@unibo.it
RI Tenti, Elena/P-7915-2018; Giannella, Maddalena/K-9090-2016; Tedeschi,
   Sara/AGG-0484-2022; Mikus, Elisa/ABO-4522-2022; Pascale,
   Renato/ABM-9366-2022; Bartoletti, Michele/K-4621-2018
OI Tenti, Elena/0000-0001-6974-0849; Giannella,
   Maddalena/0000-0001-8273-7601; Mikus, Elisa/0000-0003-2892-8700;
   Pascale, Renato/0000-0003-2687-4235; Bartoletti,
   Michele/0000-0002-1099-3283
CR Barnea Y, 2016, J ANTIMICROB CHEMOTH, V71, P460, DOI 10.1093/jac/dkv357
   Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
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   Bouza E, 2018, INT J ANTIMICROB AG, V51, P571, DOI 10.1016/j.ijantimicag.2017.11.008
   Brown PP, 2008, ANN THORAC SURG, V85, P1980, DOI 10.1016/j.athoracsur.2008.01.053
   Chen AY, 2007, INT J CLIN PRACT, V61, P853, DOI 10.1111/j.1742-1241.2007.01318.x
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NR 22
TC 13
Z9 14
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-7165
EI 2213-7173
J9 J GLOB ANTIMICROB RE
JI J. Glob. Antimicrob. Resist.
PD SEP
PY 2019
VL 18
BP 195
EP 198
DI 10.1016/j.jgar.2019.03.015
PG 4
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA IX4NA
UT WOS:000485661700041
PM 30926464
DA 2026-07-24
ER

PT J
AU Hsiao, HY
   Liu, JW
   Brey, EM
   Cheng, MH
AF Hsiao, Hui-Yi
   Liu, Jia-Wei
   Brey, Eric M.
   Cheng, Ming-Huei
TI The Effects of Negative Pressure by External Tissue Expansion Device on
   Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a
   Porcine Model
SO PLOS ONE
LA English
DT Article
ID AUTOLOGOUS FAT TRANSPLANTATION; VACUUM-ASSISTED CLOSURE; BREAST
   AUGMENTATION; MURINE MODEL; ANGIOGENESIS; INFLAMMATION; LIPOSUCTION;
   MECHANISMS
AB While pre-treating a fat transplant recipient site with negative pressure has shown promise for increasing the fat survival rate, the underlying mechanisms have not been investigated, partly due to challenges related to immobilization of vacuum domes on large animal subjects. The aim of this study was to examine the effect of negative pressure treatment by External Tissue Expansion Device (ETED) on fat grating recipient sites in a porcine model. The ETED was designed to provide negative pressure on the dorsum of swine. Pressure treatment (-70 mmHg) was applied for 1 or 3 hours every other day for 10 and 20 treatments. The treated areas (3.5 cm in diameter) were harvested and examined for histological changes, vessel density, cell proliferation (Ki67) and growth factor expression (FGF-1, VEGF and PDGB-bb). The application of the ETED increased epidermis thickness even after 1-hour treatments repeated 10 times. The results of Ki67 analysis suggested that the increasing thickness was due to cell proliferation in the epidermis. There was a more than two-fold increase in the vessel density, indicating that the ETED promotes vascularization. Unexpectedly, the treatment also increased the number of hair follicles. Negative pressure provided by the ETED increases the thickness of epidermis section of tissue, cell proliferation and vessel density. The porcine model provides a better representation of the effect of the ETED on skin tissue compared to small animal models and provides an environment for studying the mechanisms underlying the clinical benefits of negative pressure treatment.
C1 [Hsiao, Hui-Yi; Liu, Jia-Wei; Cheng, Ming-Huei] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
   [Hsiao, Hui-Yi; Liu, Jia-Wei; Cheng, Ming-Huei] Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan, Taiwan.
   [Brey, Eric M.] IIT, Dept Biomed Engn, Chicago, IL 60616 USA.
   [Brey, Eric M.] Edward Hines Vet Adm Med Ctr, Res Serv, Hines, IL USA.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Illinois
   Institute of Technology; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Edward Hines Jr. VA Hospital
RP Cheng, MH (通讯作者)，Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
EM minghueicheng@gmail.com
RI Cheng, Ming-Huei/AAD-8579-2019; HSIAO, HUI-YI/K-5428-2017
OI HSIAO, HUI-YI/0000-0003-3170-2112
FU Ministry of Science and Technology;  [NMRPG3C6193]
FX The study is supported by Ministry of Science and Technology
   (www.most.gov.tw). The financial support is founded with the grant
   number NMRPG3C6193. MHC was the PI on this funding support. The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 28
TC 13
Z9 15
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 29
PY 2016
VL 11
IS 4
AR e0154328
DI 10.1371/journal.pone.0154328
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DK8XM
UT WOS:000375212600027
PM 27128731
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Spanu, P
   Zanforlin, G
   Noto, A
   Pezzi, A
   Marzorati, S
   Reali-Forster, C
   Di Mauro, P
   Bassi, G
   Oldani, S
   Destrebecq, A
   Iapichino, G
AF Spanu, P.
   Zanforlin, G.
   Noto, A.
   Pezzi, A.
   Marzorati, S.
   Reali-Forster, C.
   Di Mauro, P.
   Bassi, G.
   Oldani, S.
   Destrebecq, A.
   Iapichino, G.
TI Intensive care of patients requiring open abdomen treatment: a
   case-series analysis
SO MINERVA ANESTESIOLOGICA
LA English
DT Article
DE Critical illness; Multiple organ failure; Conscious sedation; Enteral
   nutrition
ID CRITICALLY-ILL PATIENTS; ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED
   CLOSURE; INTRAABDOMINAL HYPERTENSION; SURGICAL-MANAGEMENT; VENTILATED
   PATIENT; DAMAGE CONTROL; GUIDELINES; SUPPORT; SEPSIS
AB Background. This retrospective overview examines the management of patients with temporary open abdomen (OA).
   Methods. The clinical characteristics and intensive care treatment of 34 consecutive patients with OA (1996-2012) were reviewed.
   Results. Average age was 61 years, SAPS II score 43, SOFA 8. Two patients had non-contaminated abdomen; 12 had intact gut (only 8 later during stay); 7 repaired gut (only later 4); 13 cutaneous stoma (later 14), and 2 entero-atmospheric fistula (later 8+1 entero-enteral). The median ICU stay was 48 [36-94] days. One quarter of the 2376 ICU-days were classified as severe sepsis/septic shock (antibiotics were given for two thirds of the stay); three quarters were with ventilation; in 95% of days sedatives were given (mainly enterally). Continuous cavity lavage was done in three quarters of days; in 3% of days patients were fasted whereas >20 kcal/kg was given for 74% of days; we fed the gut in 95% of fed-days, in half of them combined with parenteral nutrition. Complications are discussed; mortality was 32.4%, limited to the ICU stay.
   Conclusion. The intensive care of patients with OA is challenging but can achieve better outcomes than expected. Continuous abdominal lavage improves the evacuation of contaminated fluid or debris and, coupled with antiseptics and low antibiotic pressure, reinforces the control of infection. The gut can be used for nutrition (even without gastrointestinal continuity), and long-term light sedation (mainly enteral) with minimal impact on perfusion, ventilation and gut motility.
C1 [Spanu, P.; Zanforlin, G.; Noto, A.; Pezzi, A.; Marzorati, S.; Reali-Forster, C.; Di Mauro, P.; Bassi, G.; Oldani, S.; Iapichino, G.] Polo Univ San Paolo, Serv Anestesia & Rianimaz, Milan, Italy.
   [Bassi, G.] Osped Niguarda Ca Granda, Serv Anestesia & Rianimaz, Milan, Italy.
   [Destrebecq, A.] Univ Milan, Dipartimento Salute Pubbl Microbiol & Virol, I-20142 Milan, Italy.
   [Iapichino, G.] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, I-20142 Milan, Italy.
C3 Ospedale Niguarda Ca' Granda; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; University of Milan; University of Milan
RP Iapichino, G (通讯作者)，Univ Milan, Azienda Osped San Paolo Milano, UO Anestesia & Rianimaz, Via Di Rudini 8, I-20142 Milan, Italy.
EM g.iapichino@unimi.it
RI Destrebecq, Anne/L-7920-2016; Bassi, Gianluigi/AAG-5627-2021
OI Destrebecq, Anne/0000-0003-4250-7881; 
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NR 40
TC 6
Z9 7
U1 0
U2 9
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0375-9393
EI 1827-1596
J9 MINERVA ANESTESIOL
JI Minerva Anestesiol.
PD APR
PY 2013
VL 79
IS 4
BP 349
EP 359
PG 11
WC Anesthesiology; Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA 168BM
UT WOS:000320680700004
PM 23419332
DA 2026-07-24
ER

PT J
AU Argenta, LC
   Morykwas, MJ
   Mays, JJ
   Thompson, EA
   Hammon, JW
   Jordan, JE
AF Argenta, Louis C.
   Morykwas, Michael J.
   Mays, Jennifer J.
   Thompson, Edreca A.
   Hammon, John W.
   Jordan, James E.
TI Reduction of Myocardial Ischemia-Reperfusion Injury by Mechanical Tissue
   Resuscitation Using Sub-Atmospheric Pressure
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; VACUUM-ASSISTED CLOSURE; CLINICAL
   IMPLICATIONS; CONSEQUENCES; GENERATION
AB P>Background: Reperfusion-induced injury after myocardial infarction is associated with a well-defined sequence of early and late cardiomyocyte death. Most present attempts to ameliorate this sequence focus on a single facet of the complex process in an attempt to salvage cardiomyocytes. We examined, as proof of concept, the effects of mechanical tissue resuscitation (MTR) with controlled negative pressure on myocardial injury following acute myocardial infarction. Methods: Anesthetized swine were subjected to 75 minutes of left coronary artery occlusion and three hours of reperfusion. Animals were assigned to one of three groups: (A) untreated control; treatment of involved myocardium for 180 minutes of MTR with (B) -50 mmHg, or (C) -125 mmHg. Results: All three groups were subjected to equivalent ischemic stress. Treatment of the ischemic area with MTR for 180 minutes significantly (p < 0.001) reduced infarct size (area of necrosis/area at risk) in both treatment groups compared to control: 9.3 +/- 1.8% (-50 mmHg) and 11.9 +/- 1.2% (-125 mmHg) versus 26.4 +/- 2.1% (control). Total area of cell death was reduced by 65% with -50 mmHg treatment and 55% in the -125 mmHg group. Conclusions: Treatment of ischemic myocardium with MTR, for a controlled period of time during reperfusion, successfully reduced the extent of myocardial death after acute myocardial infarction. These data provide evidence that MTR using subatmospheric pressure may be a simple, efficacious, nonpharmacological, mechanical strategy for decreasing cardiomyocyte death following myocardial infarction, which can be delivered in the operating room. (J Card Surg 2010;25:247-252).
C1 [Mays, Jennifer J.; Hammon, John W.; Jordan, James E.] Wake Forest Univ Hlth Sci, Dept Cardiothorac Surg, Winston Salem, NC USA.
   [Argenta, Louis C.; Morykwas, Michael J.; Thompson, Edreca A.] Wake Forest Univ Hlth Sci, Dept Plast & Reconstruct Surg, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Argenta, LC (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM largenta@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
FU Cheek Foundation Endowment of the Department of Plastic and
   Reconstructive Surgery of Wake Forest University; RepaiRx Laboratories
   of the Department of Plastic and Reconstructive Surgery at Wake Forest
   University Medical Center
FX This project was funded in part by the Cheek Foundation Endowment of the
   Department of Plastic and Reconstructive Surgery of Wake Forest
   University and by the RepaiRx Laboratories of the Department of Plastic
   and Reconstructive Surgery at Wake Forest University Medical Center.
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NR 19
TC 6
Z9 7
U1 0
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0886-0440
J9 J CARDIAC SURG
JI J. Card. Surg.
PD MAR
PY 2010
VL 25
IS 2
BP 247
EP 252
DI 10.1111/j.1540-8191.2009.00972.x
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 563PM
UT WOS:000275145200036
PM 20492032
DA 2026-07-24
ER

PT J
AU Mamun, AA
   Shao, CX
   Geng, PW
   Wang, SH
   Xiao, J
AF Mamun, Abdullah Al
   Shao, Chuxiao
   Geng, Peiwu
   Wang, Shuanghu
   Xiao, Jian
TI Recent advances in molecular mechanisms of skin wound healing and its
   treatments
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE skin; skin wound healing; immune cell-wound healing; wound physical
   therapy; stem cell therapy
ID MESENCHYMAL STEM-CELLS; VACUUM-ASSISTED CLOSURE; ADAPTIVE
   IMMUNE-RESPONSES; ENDOTHELIAL GROWTH-FACTOR; FRAMEWORK NUCLEIC-ACIDS;
   DRUG-DELIVERY SYSTEMS; INNATE LYMPHOID-CELLS; BONE-MARROW; MAST-CELLS;
   B-CELLS
AB The skin, being a multifaceted organ, performs a pivotal function in the complicated wound-healing procedure, which encompasses the triggering of several cellular entities and signaling cascades. Aberrations in the typical healing process of wounds may result in atypical scar development and the establishment of a persistent condition, rendering patients more vulnerable to infections. Chronic burns and wounds have a detrimental effect on the overall quality of life of patients, resulting in higher levels of physical discomfort and socio-economic complexities. The occurrence and frequency of prolonged wounds are on the rise as a result of aging people, hence contributing to escalated expenditures within the healthcare system. The clinical evaluation and treatment of chronic wounds continue to pose challenges despite the advancement of different therapeutic approaches. This is mainly owing to the prolonged treatment duration and intricate processes involved in wound healing. Many conventional methods, such as the administration of growth factors, the use of wound dressings, and the application of skin grafts, are used to ease the process of wound healing across diverse wound types. Nevertheless, these therapeutic approaches may only be practical for some wounds, highlighting the need to advance alternative treatment modalities. Novel wound care technologies, such as nanotherapeutics, stem cell treatment, and 3D bioprinting, aim to improve therapeutic efficacy, prioritize skin regeneration, and minimize adverse effects. This review provides an updated overview of recent advancements in chronic wound healing and therapeutic management using innovative approaches.
C1 [Mamun, Abdullah Al; Shao, Chuxiao; Geng, Peiwu; Wang, Shuanghu; Xiao, Jian] Wenzhou Med Univ, Lishui Hosp, Lishui Peoples Hosp, Cent Lab, Lishui, Zhejiang, Peoples R China.
   [Xiao, Jian] Wenzhou Med Univ, Mol Pharmacol Res Ctr, Sch Pharmaceut Sci, Wenzhou, Peoples R China.
   [Xiao, Jian] Wenzhou Med Univ, Affiliated Hosp 1, Dept Wound Healing, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Wang, SH; Xiao, J (通讯作者)，Wenzhou Med Univ, Lishui Hosp, Lishui Peoples Hosp, Cent Lab, Lishui, Zhejiang, Peoples R China.; Xiao, J (通讯作者)，Wenzhou Med Univ, Mol Pharmacol Res Ctr, Sch Pharmaceut Sci, Wenzhou, Peoples R China.; Xiao, J (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 1, Dept Wound Healing, Wenzhou, Peoples R China.
EM wangshuanghu@lsu.edu.cn; xfxj2000@126.com
RI Mamun, Abdullah Al/AAY-5786-2020; Xiao, Jian/GYU-4351-2022; wang,
   shuanghu/AAO-6445-2021
OI Mamun, Abdullah Al/0000-0001-9936-3925; Xiao, Jian/0000-0001-7374-6506; 
FU Zhejiang Provincial Natural Science Foundation of China [LQ21H090001];
   National Natural Science Foundation of China [82172428, 81972150];
   Post-Doctoral Research Start-up Fund of Lishui People's Hospital,
   Zhejiang, China [2023bsh001]; Public Welfare Technology Research Funding
   Project of Zhejiang [LTGY24H100002, LTGY23H160034]; Key Research and
   Development Project of Lishui [2022ZDYF23]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This review was
   supported by the Zhejiang Provincial Natural Science Foundation of China
   (LQ21H090001), the National Natural Science Foundation of China (Grants
   82172428 and 81972150), the Post-Doctoral Research Start-up Fund of
   Lishui People's Hospital, Zhejiang, China (2023bsh001) and the Public
   Welfare Technology Research Funding Project of Zhejiang (LTGY24H100002
   and LTGY23H160034), and Key Research and Development Project of Lishui
   (2022ZDYF23).
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NR 320
TC 208
Z9 242
U1 57
U2 240
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAY 21
PY 2024
VL 15
AR 1395479
DI 10.3389/fimmu.2024.1395479
PG 29
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA SW7B8
UT WOS:001237539900001
PM 38835782
OA Green Submitted, gold
HC Y
HP Y
DA 2026-07-24
ER

PT J
AU Gupta, E
   Tennison, JM
   Shin, KY
   Fu, JB
   de Moraes, AR
   Naqvi, SMA
   Fellman, B
   Bruera, E
AF Gupta, Ekta
   Tennison, Jegy M.
   Shin, Ki Y.
   Fu, Jack B.
   Rozman de Moraes, Aline
   Naqvi, Syed Mujtaba Ali
   Fellman, Bryan
   Bruera, Eduardo
TI Frequency, Characteristics, and Risk Factors for Falls at an Inpatient
   Cancer Rehabilitation Unit
SO JCO ONCOLOGY PRACTICE
LA English
DT Article
ID FUNCTIONAL INDEPENDENCE MEASURE; CHARLSON COMORBIDITY INDEX;
   HOSPITALIZED-PATIENTS; OLDER-ADULTS; PREDICTORS; INJURIES; SYSTEM; RATES
AB PURPOSE Falls in the hospital can lead to adverse events, including injuries. Studies have shown that patients with cancer and those undergoing inpatient rehabilitation (IPR) are at higher risk for falls. Therefore, we measured the frequency, degree of harm, and characteristics of patients who fell in an inpatient cancer rehabilitation unit.METHODS A retrospective review was conducted on inpatient cancer rehabilitation patients admitted from January 2012 to February 2016. Fall frequency, degree of harm, fall circumstances, cancer type, patient's fall risk score on the basis of the MD Anderson Cancer Center Adult Inpatient Fall Risk Assessment Tool (MAIFRAT), length of stay, and risk factors were evaluated for patients.RESULTS There were 72 out of 1,571 unique individual falls (4.6%), with a falls incidence of 3.76 falls per 1,000 patient-days. Most fallers (86%) suffered no harm. Risk factors for falls included presence of patient-controlled analgesia pump (P = .03), pump such as insulin or wound vacuum-assisted closure (P < .01), nasogastric, gastric, or chest tube (P = .05), and higher MAIFRAT score (P < .01). The fallers were younger (62 v 66; P = .04), had a longer IPR stay (13 v 9; P = .03), and had a lower Charlson comorbidity index (6 v 8; P < .01).CONCLUSION The frequency and degree of harm for falls in the IPR unit were less than previous studies, which suggests that mobilization for these patients with cancer is safe. The presence of certain medical devices may contribute to fall risk, and more research is needed to better prevent falls in this higher-risk subgroup.
C1 [Gupta, Ekta; Tennison, Jegy M.; Shin, Ki Y.; Fu, Jack B.; Rozman de Moraes, Aline; Bruera, Eduardo] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, Houston, TX USA.
   [Naqvi, Syed Mujtaba Ali] Univ Kentucky, Coll Med, Lexington, KY USA.
   [Fellman, Bryan] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX USA.
   [Gupta, Ekta] Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Kentucky; University of Texas System; UTMD Anderson Cancer Center;
   University of Texas System; UTMD Anderson Cancer Center
RP Gupta, E (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Palliat Rehabil & Integrat Med, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM EGupta@mdanderson.org
RI ; Tennison, Jegy/HJA-8091-2022; Bruera, Eduardo/AAA-1550-2022
OI Fu, Jack/0000-0002-9397-0668; Rozman de Moraes,
   Aline/0000-0002-7047-4792; Tennison, Jegy/0000-0002-6026-2294; Bruera,
   Eduardo/0000-0002-8745-0412; Gupta Sharma, Ekta/0000-0003-1716-7803
FU The authors thank Beverly Nelson, PhD, RN, NEA-BC; Cathie Mbango, RN,
   MPH; and Janet L. Williams.; National Cancer Institute [P30CA016672]
   Funding Source: NIH RePORTER
FX The authors thank Beverly Nelson, PhD, RN, NEA-BC; Cathie Mbango, RN,
   MPH; and Janet L. Williams.
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NR 46
TC 4
Z9 4
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2688-1527
EI 2688-1535
J9 JCO ONCOL PRACT
JI JCO Oncol. Pract.
PD SEP
PY 2023
VL 19
IS 9
BP 741
EP +
DI 10.1200/OP.23.00188
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA Y2DH2
UT WOS:001103419700002
PM 37339393
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Marzouk, M
   Baillot, R
   Kalavrouziotis, D
   Amhis, N
   Nader, J
   Hould, FS
   Biertho, L
   Mohammadi, S
   Malas, T
AF Marzouk, Mohamed
   Baillot, Richard
   Kalavrouziotis, Dimitris
   Amhis, Nawal
   Nader, Joseph
   Hould, Frederic S.
   Biertho, Laurent
   Mohammadi, Siamak
   Malas, Tarek
TI Early to midterm survival of patients with deep sternal wound infection
   managed with laparoscopically harvested omentum
SO JOURNAL OF CARDIAC SURGERY
LA English
DT Article
DE cardiovascular pathology; cardiovascular research
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; COMPLICATIONS; THERAPY; IMPACT;
   FLAP
AB Objective: The optimal management of deep sternal wound infection (DWSI) remains controversial. Our objective was to evaluate outcomes of patients with DSWI managed with transposition of laparoscopically harvested omentum (LHO).
   Methods: Between 2000 and 2020, a total of 38,623 adult patients who underwent full median sternotomy for cardiac surgery were analyzed retrospectively at our institution. DSWI occurred in 455 (1.2%), of whom 364 (93.2%) were managed with pectoralis myocutaneous flap (PMF) and 33 (7.2%) with LHO. Univariate and multivariate analysis models were used to determine predictors of cumulative late mortality and adjusted survival curves were generated.
   Results: Among patients who received LHO, average age was 65.7 +/- 9.7 years and a larger proportion of patients were male. A majority of patients (88%) had coronary bypass surgery, with bilateral internal mammary arteries use in only 21.2%. Mean length of stay (LOS) was 58.90 days and early hospital mortality occurred in 4 patients (12.1%). Patients who received LHO compared to only PMF had larger body mass index and had more heart failure. Furthermore, the hospital LOS was also significantly prolonged in the LHO group (58.9 vs. 27.4 days, p = .002), with a slightly higher in-hospital mortality (12.1% vs. 3.3%, p = .03). Late survival for LHO patients at 5 and 10 years was 71.9% and 44.8%, respectively.
   Conclusion: Use of LHO is a safe and viable alternative to traditional myocutaneous flaps to manage complex DSWI. Early and late survival were favorable in this highrisk population.
C1 [Marzouk, Mohamed; Baillot, Richard; Kalavrouziotis, Dimitris; Amhis, Nawal; Nader, Joseph; Mohammadi, Siamak; Malas, Tarek] Laval Univ, Quebec Heart & Lung Inst, Dept Cardiovasc Surg, Quebec City, PQ, Canada.
   [Hould, Frederic S.; Biertho, Laurent] Laval Univ, Dept Gen Surg, Quebec City, PQ, Canada.
C3 Laval University; Quebec Heart & Lung Institute; Laval University
RP Malas, T (通讯作者)，2725 Chemin St Foy, Quebec City, PQ G1V 4G5, Canada.
EM tarek.malas@gmail.com
OI Amhis, Nawal/0009-0003-6857-4756
CR Baillot R, 2010, EUR J CARDIO-THORAC, V37, P880, DOI 10.1016/j.ejcts.2009.09.023
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NR 22
TC 4
Z9 5
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0886-0440
EI 1540-8191
J9 J CARDIAC SURG
JI J. Card. Surg.
PD NOV
PY 2021
VL 36
IS 11
BP 4083
EP 4089
DI 10.1111/jocs.15955
EA SEP 2021
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA UZ7DB
UT WOS:000693211000001
PM 34473370
DA 2026-07-24
ER

PT J
AU Popivanov, GI
   Mutafchiyski, VM
   Cirocchi, R
   Chipeva, SD
   Vasilev, VV
   Kjossev, KT
   Tabakov, MS
AF Popivanov, G. I.
   Mutafchiyski, V. M.
   Cirocchi, R.
   Chipeva, S. D.
   Vasilev, V. V.
   Kjossev, K. Ts.
   Tabakov, M. S.
TI Endoluminal negative pressure therapy in colorectal anastomotic leaks
SO COLORECTAL DISEASE
LA English
DT Review
DE colorectal surgery; complications; colorectal anastomotic leak;
   endoluminal negative pressure therapy; endosponge treatment
ID VACUUM-ASSISTED CLOSURE; ENDO-SPONGE TREATMENT; EXPERIENCE; RESECTION;
   REVERSAL; ETVARD
AB Aim The aim of the present work was to perform an up-to-date review of the literature on endoluminal negative pressure therapy for colorectal anastomotic leak.
   Method An electronic search in PubMed and Google Scholar and a manual search without language restrictions were performed on 25 January 2019. Only original series reporting endoluminal negative pressure therapy in colorectal anastomotic leaks were included. The primary outcome was the success rate (complete closure of the abscess cavity). The secondary outcomes were the rates of complications and stoma closure.
   Results Nineteen series with a total of 295 cases were analysed. The median distance of the anastomosis from the anal verge and the size of the abscess were 5.65 cm (4.9-10) and 6.0 cm (5-8.1) respectively. In 84.5% (78%-91%) the stoma was created at the first intervention. Neoadjuvant therapy was performed in 48.6% (3%-60%). Median 7 sponges (2-34) were used with median negative pressure 150 mmHg (125-700) for a median of 31 days (14-127). The success rate was 85.4% (80%-91%) with ileostomy closure in 72.6%. Complications were observed in 19% (13%-25%): abscesses 11.5% and anastomotic stenosis 4.4%. Laparotomy was required in 15% of the complications. The stoma was the only significant predictor for the success of the therapy (0.007, SE 0.004, P = 0.040).
   Conclusions The initial experience looks promising with an 85% success rate, which precludes risky re-resections with redo anastomosis or Hartmann's procedure. Despite the good initial results, definitive conclusions cannot be drawn because of the small sample size and the lack of high-quality comparative studies.
C1 [Popivanov, G. I.; Mutafchiyski, V. M.; Vasilev, V. V.; Kjossev, K. Ts.] Mil Med Acad, Dept Surg, Sofia, Bulgaria.
   [Cirocchi, R.] Univ Perugia, Dept Surg & Surg Sci, Perugia, Italy.
   [Chipeva, S. D.] Univ Natl & World Econ, Dept Stat & Econometr, Sofia, Bulgaria.
   [Tabakov, M. S.] MHAT Sv Ivan Rilski, Clin Abdominal Surg, Sofia, Bulgaria.
C3 Military Medical Academy Sofia; University of Perugia; University of
   National & World Economics - Bulgaria
RP Popivanov, GI (通讯作者)，Mil Med Acad, Sv Georgi Sofiiski Str 3, Sofia 1606, Bulgaria.
EM gerasimpopivanov@rocketmail.com
RI Popivanov, Georgi/IVH-4670-2023; Kjossev, Kirien/KQV-3036-2024;
   Cirocchi, Roberto/I-1197-2014
OI Popivanov, Georgi/0000-0001-9618-3187; 
CR [Anonymous], J HEPATO GASTRO 0625
   [Anonymous], 2013, GE Port J Gastroenterol
   [Anonymous], 2014, Surg Sci
   [Anonymous], NEGATIVE PRESSURE WO
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NR 41
TC 24
Z9 28
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD MAR
PY 2020
VL 22
IS 3
BP 243
EP 253
DI 10.1111/codi.14754
PG 11
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA KR9JZ
UT WOS:000517930700003
PM 31274227
DA 2026-07-24
ER

PT J
AU Jiménez-Fuertes, M
   García-Olmo, DC
   Puy, S
   Beisani, M
   Planells, F
   Boldó, A
   Ruiz-Tovar, J
   Durán, M
   García-Olmo, D
AF Jimenez-Fuertes, Montiel
   Garcia-Olmo, Dolores C.
   Puy, Sara
   Beisani, Marc
   Planells, Francisca
   Boldo, Alba
   Ruiz-Tovar, Jaime
   Duran, Manuel
   Garcia-Olmo, Damian
TI Effects of negative-pressure therapy with and without ropivacaine
   instillation in the early evolution of severe peritonitis in pigs
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Sepsis; Peritonitis; Temporary abdominal closure; Negative-pressure
   therapy; Instillation; Septic open abdomen
ID VACUUM-ASSISTED CLOSURE; INTRAABDOMINAL HYPERTENSION; INFLAMMATION;
   LIDOCAINE; CYTOKINES; SEPSIS; INJURY; FLUID; RATS
AB Purpose The abdomen is the second most common source of sepsis and secondary peritonitis, which likely lead to death. In the present study, we hypothesized that instillation of local anesthetics into the peritoneum might mitigate the systemic inflammatory response syndrome (SIRS) in the open abdomen when combined with negative-pressure therapy (NPT) to treat severe peritonitis. Methods We performed a study in 21 pigs applying a model of sepsis based on ischemia/reperfusion and fecal spread into the peritoneum. The pigs were randomized into three groups, and treated for 6 h as follows: Group A: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy; Group B: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy plus abdominal instillation with physiological saline solution (PSS); and Group C: temporary abdominal closure with ABTHERA (TM) Open Abdomen Negative-Pressure Therapy plus peritoneal instillation with a solution of ropivacaine in PPS. Results A comparison between the three groups revealed no statistically significant difference for any of the parameters registered (p > 0.05), i.e., intra-abdominal pressure, blood pressure, heart rate, O-2 saturation, diuresis, body temperature, and blood levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF alpha), and c-reactive protein (CRP). In addition, histological studies of the liver, ileum, kidney and lung showed no difference between groups. Conclusions The use of abdominal instillation (with or without ropivacaine) did not change the effect of 6 h of NPT after sepsis in animals with open abdomen. The absence of adverse effects suggests that longer treatments should be tested.
C1 [Jimenez-Fuertes, Montiel; Ruiz-Tovar, Jaime; Duran, Manuel] Rey Juan Carlos Univ Hosp, Fdn Jimenez Diaz IIS FJD, Madrid, Spain.
   [Jimenez-Fuertes, Montiel; Ruiz-Tovar, Jaime; Duran, Manuel] Inst Invest Sanitaria, Madrid, Spain.
   [Garcia-Olmo, Dolores C.; Puy, Sara; Beisani, Marc; Planells, Francisca; Boldo, Alba] IRBLleida, CREBA, Lleida, Spain.
   [Beisani, Marc] Hosp Mar, Dept Surg, Barcelona, Spain.
   [Garcia-Olmo, Damian] Univ Hosp, Fdn Jimenez Diaz, Dept Gen & Digest Surg, Madrid, Spain.
   [Garcia-Olmo, Damian] Inst Invest Sanitaria IIS FJD, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Hospital del Mar Research Institute; Hospital
   del Mar; Fundacion Jimenez Diaz; Fundacion Jimenez Diaz
RP Jiménez-Fuertes, M (通讯作者)，Rey Juan Carlos Univ Hosp, Fdn Jimenez Diaz IIS FJD, Madrid, Spain.; Jiménez-Fuertes, M (通讯作者)，Inst Invest Sanitaria, Madrid, Spain.
EM montiel.jf77@gmail.com
RI ; Duran-Poveda, Manuel/AAS-6519-2021; Garcia Olmo, Damian/L-5733-2014
OI Jimenez Fuertes, Montiel/0009-0002-3836-0944; Garcia Olmo,
   Damian/0000-0002-9369-2338; Beisani, Marc/0000-0002-3773-5209;
   Duran-Poveda, Manuel/0000-0002-4335-7208; Garcia Olmo,
   Damian/0000-0002-9369-2338
FU Acelity/KCI, San Antonio, TX, USA
FX This research received a specific grant from Acelity/KCI, San Antonio,
   TX, USA.
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NR 31
TC 1
Z9 1
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD APR
PY 2021
VL 47
IS 2
SI SI
BP 597
EP 606
DI 10.1007/s00068-019-01244-9
EA OCT 2019
PG 10
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA RH0SL
UT WOS:000494196300002
PM 31641785
DA 2026-07-24
ER

PT J
AU Heise, D
   Eickhoff, R
   Kroh, A
   Binnebösel, M
   Klinge, U
   Klink, CD
   Neumann, UP
   Lambertz, A
AF Heise, D.
   Eickhoff, R.
   Kroh, A.
   Binneboesel, M.
   Klinge, U.
   Klink, C. D.
   Neumann, U. P.
   Lambertz, A.
TI Elastic TPU Mesh as Abdominal Wall Inlay Significantly Reduces Defect
   Size in a Minipig Model
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article
DE elastic thermoplastic polyurethane (TPU) mesh; polyvinylidene fluoride
   (PVDF) mesh; inlay; open abdomen; minipig model; defect size
ID MEDIATED FASCIAL TRACTION; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN
   TREATMENT; NEGATIVE-PRESSURE; COMPARTMENT SYNDROME; WOUND CLOSURE;
   MANAGEMENT; POROSITY; THERAPY
AB Background: The open abdomen with mesh implantation, followed by early reoperation with fascial closure, is a modern surgical approach in difficult clinical situations such as severe abdominal sepsis. As early fascial closure is not possible in many cases, mesh-mediated fascial traction is helpful for conditioning of a minimized ventral hernia after open abdomen. The aim of this study was to evaluate the clinical utilization of an innovative elastic thermoplastic polyurethane mesh (TPU) as an abdominal wall inlay in a minipig model. Methods: Ten minipigs were divided in two groups, either receiving an elastic TPU mesh or a nonelastic polyvinylidene fluoride (PVDF) mesh in inlay position of the abdominal wall. After 8 weeks, mesh expansion and abdominal wall defect size were measured. Finally, pigs were euthanized and abdominal walls were explanted for histological and immunohistochemical assessment. Results: Eight weeks after abdominal wall replacement, transversal diameter of the fascial defect in the TPU group was significantly smaller than in the PVDF group (4.5 cm vs. 7.4 cm; p = 0.047). Immunhistochemical analysis showed increased Ki67 positive cells (p = 0.003) and a higher number of apoptotic cells (p = 0.047) after abdominal wall replacement with a TPU mesh. Collagen type I/III ratio was increased in the PVDF group (p = 0.011). Conclusion: Implantation of an elastic TPU mesh as abdominal wall inlay is a promising approach to reduce the size of the ventral hernia after open abdomen by mesh-mediated traction. However, this effect was associated with a slightly increased foreign body reaction in comparison to the nonelastic PVDF.
C1 [Heise, D.; Eickhoff, R.; Kroh, A.; Binneboesel, M.; Klinge, U.; Klink, C. D.; Neumann, U. P.; Lambertz, A.] RWTH Aachen Univ Hosp, Dept Gen Visceral & Transplantat Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
   [Neumann, U. P.] Maastricht Univ, Med Ctr, Dept Gen Surg, Maastricht, Netherlands.
C3 RWTH Aachen University; RWTH Aachen University Hospital; Maastricht
   University
RP Heise, D (通讯作者)，RWTH Aachen Univ Hosp, Dept Gen Visceral & Transplantat Surg, Pauwelsstr 30, D-52074 Aachen, Germany.
EM dheise@ukaachen.de
FU Federal Ministry of Education and Research (Berlin, Germany) [360665]
FX This study was supported by the Federal Ministry of Education and
   Research (Berlin, Germany), Grant no.: 360665. Mesh development was
   conducted in collaboration with FEG TextiltechnikmbH, Aachen, Germany.
CR Arjun GN, 2012, J BIOMED MATER RES A, V100A, P3042, DOI 10.1002/jbm.a.34255
   Björck M, 2011, AM SURGEON, V77, pS58
   Brandl A, 2014, HERNIA, V18, P105, DOI 10.1007/s10029-013-1064-0
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NR 32
TC 3
Z9 4
U1 1
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD AUG 18
PY 2019
VL 32
IS 6
BP 501
EP 506
DI 10.1080/08941939.2018.1436207
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LP9GY
UT WOS:000534625200003
PM 29469618
DA 2026-07-24
ER

PT J
AU Bejko, J
   Tarzia, V
   Carrozzini, M
   Gallo, M
   Bortolussi, G
   Comisso, M
   Testolin, L
   Guglielmi, C
   De Franceschi, M
   Bianco, R
   Gerosa, G
   Bottio, T
AF Bejko, Jonida
   Tarzia, Vincenzo
   Carrozzini, Massimiliano
   Gallo, Michele
   Bortolussi, Giacomo
   Comisso, Marina
   Testolin, Luca
   Guglielmi, Cosimo
   De Franceschi, Marco
   Bianco, Roberto
   Gerosa, Gino
   Bottio, Tomaso
TI Comparison of Efficacy and Cost of Iodine Impregnated Drape vs. Standard
   Drape in Cardiac Surgery: Study in 5100 Patients
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Article
DE Pre-operative and post-operative care; Wound closure; Healing;
   Dehiscence; Wound infection
ID OPEN-HEART-SURGERY; STERNAL WOUND-INFECTION; RISK-FACTORS;
   MEDIASTINITIS; RESISTANT; IMPACT; DEEP
AB We sought to examine the efficacy in preventing surgical site infection (SSI) in cardiac surgery, using two different incise drapes (not iodine-impregnated and iodine-impregnated). A cost analysis was also considered. Between January 2008 and March 2015, 5100 consecutive cardiac surgery patients, who underwent surgery in our Institute, were prospectively collected. A total of 3320 patients received a standard not iodine-impregnated steri-drape (group A), and 1780 patients received Ioban(R) 2 drape (group B). We investigated, by a propensity matched analysis, whether the use of standard incise drape or iodine-impregnated drape would impact upon SSI rate. Totally, 808 patients for each group were matched for the available risk factors. Overall incidence of SSI was significantly higher in group A (6.5 versus 1.9 %) (p=0.001). Superficial SSI incidence was significantly higher in group A (5.1 vs 1.6 %) (p=0.002). Deep SSI resulted higher in group A (1.4 %) than in group B (0.4 %), although not significantly (p=0.11). Consequently, the need for vacuum-assisted closure (VAC) therapy use resulted 4.3 % in group A versus 1.2% in group B (p=0.001). Overall costs for groups A and B were 12.494.912 (sic) and 11.721.417 (sic), respectively. The Ioban(R) 2 offered totally 773.495 (sic) cost savings compared to standard steri-drape. Ioban 2 drape assured a significantly lower incidence of SSI. Additionally, Ioban(R) 2 drape proved to be cost-effective in cardiac surgery.
C1 [Bejko, Jonida; Tarzia, Vincenzo; Carrozzini, Massimiliano; Gallo, Michele; Bortolussi, Giacomo; Comisso, Marina; Testolin, Luca; Guglielmi, Cosimo; De Franceschi, Marco; Bianco, Roberto; Gerosa, Gino; Bottio, Tomaso] Univ Padua, Dept Cardiac Thorac & Vasc Sci, I-35100 Padua, Italy.
C3 University of Padua
RP Bottio, T (通讯作者)，Univ Padua, Dept Cardiac Thorac & Vasc Sci, Via Giustiniani 2, I-35100 Padua, Italy.
EM tbottio@gmail.com
RI Bianco, Roberto/AAC-2343-2019; Carrozzini, Massimiliano/M-7138-2018;
   Bortolussi, Giacomo/AAM-3278-2020; Tarzia, Vincenzo/AAC-2097-2019;
   Gallo, Michele/H-8957-2019; BOTTIO, TOMASO/AAQ-9040-2020
OI Bianco, Roberto/0000-0002-6485-1205; Carrozzini,
   Massimiliano/0000-0001-5506-0201; Bortolussi,
   Giacomo/0000-0003-3640-1597; Tarzia, Vincenzo/0000-0003-2360-2031;
   Gallo, Michele/0000-0002-1392-4558; BOTTIO, TOMASO/0000-0001-7299-2983
CR [Anonymous], COCHRANE DATABASE SY
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NR 17
TC 38
Z9 40
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD OCT
PY 2015
VL 8
IS 7
BP 431
EP 437
DI 10.1007/s12265-015-9653-1
PG 7
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA CU7MR
UT WOS:000363724500005
PM 26374143
DA 2026-07-24
ER

PT J
AU Hallock, GG
AF Hallock, Geoffrey G.
TI Evidence-Based Medicine: Lower Extremity Acute Trauma
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID MUSCLE PERFORATOR FLAPS; ANTEROLATERAL THIGH FLAPS;
   VACUUM-ASSISTED-CLOSURE; SOFT-TISSUE DEFECTS; LOWER LEG; RECONSTRUCTIVE
   SURGERY; TIBIAL FRACTURES; AMPUTATION; FOOT; EXPERIENCE
AB to: 1. Understand the steps for evaluation of a patient with a lower extremity wound before initiating medical or surgical intervention. 2. Acknowledge that limb amputation and salvage can both be appropriate definitive treatment options. 3. Select proper nonsurgical or surgical techniques for wound management. 4. Appreciate the difference in the expected outcome according to the perspective of the physician versus the patient.
   Summary: Lower extremity acute trauma is a common occurrence. Ultimate functional outcomes are similar whether amputation or salvage by limb reconstruction is the treatment pathway chosen. The reconstructive surgeon must be knowledgeable enough to assist in making the correct decision for either option. Debridement is the cornerstone of management before embarking on definitive wound closure. Nonsurgical devices have provided a transition to optimize the wound, sometimes even replacing or lessening the need for vascularized tissues to permit this coverage. Nevertheless, flaps will always have a role varying according to the involved region of the lower extremity. Traditional muscle flaps can often today be supplemented by the use of perforator flaps. The latter have great versatility as pedicled flaps for all zones of the lower limb, in addition to being a dependable free flap alternative. Horrendous injuries can now be expected to be salvaged, with a reasonable aesthetic result possible and with minimal donor-site morbidity. Preferences by both physicians and patients tend to favor the course to limb salvage, but it must be appreciated by the care-giver that it is always the patient who has to live with the residua of an altered limb and lifestyle.
C1 [Hallock, Geoffrey G.] Lehigh Valley Hosp, Allentown, PA USA.
C3 Lehigh Valley Hospital
RP Hallock, GG (通讯作者)，1230 South Cedar Crest Blvd,Suite 306, Allentown, PA 18103 USA.
EM gghallock@hotmail.com
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   Ullmann Y, 2006, ANN PLAS SURG, V56, P401, DOI 10.1097/01.sap.0000201552.81612.68
   Wei FC, 2002, PLAST RECONSTR SURG, V109, P2227, DOI 10.1097/00006534-200206000-00008
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NR 52
TC 40
Z9 49
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2013
VL 132
IS 6
BP 1733
EP 1741
DI 10.1097/PRS.0b013e3182a80925
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300LQ
UT WOS:000330465800080
PM 24281598
DA 2026-07-24
ER

PT J
AU Deschka, H
   Erler, S
   El-Ayoubi, L
   Vogel, C
   Vöhringer, L
   Wimmer-Greinecker, G
AF Deschka, Heinz
   Erler, Stefan
   El-Ayoubi, Lemir
   Vogel, Cordula
   Voehringer, Luise
   Wimmer-Greinecker, Gerhard
TI Suction-irrigation drainage: an underestimated therapeutic option for
   surgical treatment of deep sternal wound infections†
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Suction-irrigation drainage; Wound closure
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE MEDIASTINITIS; POSTSTERNOTOMY
   MEDIASTINITIS; MANAGEMENT
AB Deep sternal wound infections are significant and severe complications following cardiac surgery and substantially influence perioperative morbidity and mortality. We present the experience of our department using two different surgical treatments over a three-year period.
   Between January 2009 and December 2011, a total of 3274 cardiac procedures with complete median sternotomy were performed in our department. In 94 patients (3%), a deep sternal wound infection occurred, including sternal instability with consecutive surgical treatment. The patients either received wound debridement with sternum refixation and suction-irrigation drainage (SID; n = 72) or sternum refixation only (RF; n = 22) if there was sternal instability with limited signs of infection. SID was routinely installed for 7 days: the irrigation solution contained neomycin. In all cases, swabs were taken and analysed. The different methods were evaluated in respect of their clinical outcomes.
   The success rate-defined as single, uncomplicated procedure-of the SID treatment was 74%, compared with 59% of the isolated sternum refixation. Complications included continuous infection, recurrence of sternal instability and wound necrosis. Eighty-eight percent of the swabs in the SID group were positive, compared with 32% in the sternal refixation only group. The dominating pathogenic germs were coagulase-negative staphylococci and staphylococcus aureus. Mortality was 10% for the SID group and 5% for the RF group.
   Contrary to accepted opinion, the suction-irrigation drainage is an appropriate therapy for deep sternal wound infections. Nevertheless, deep sternal wound infections after cardiac surgery remain severe complications and are related to increased morbidity and mortality.
C1 [Deschka, Heinz; Erler, Stefan; El-Ayoubi, Lemir; Vogel, Cordula; Voehringer, Luise; Wimmer-Greinecker, Gerhard] Heart & Vessel Ctr Bad Bevensen, Dept Cardiothorac Surg, D-29549 Bad Bevensen, Germany.
RP Deschka, H (通讯作者)，Heart & Vessel Ctr Bad Bevensen, Dept Cardiothorac Surg, Romstederstr 25, D-29549 Bad Bevensen, Germany.
EM deschkaheinz@hotmail.com
OI Vöhringer, Luise/0009-0001-4741-2980
CR Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
   Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Biefer HRC, 2012, EUR J CARDIO-THORAC, V42, P306, DOI 10.1093/ejcts/ezr326
   Borger MA, 1998, ANN THORAC SURG, V65, P1050, DOI 10.1016/S0003-4975(98)00063-0
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Merrill WH, 2004, ANN THORAC SURG, V78, P608, DOI 10.1016/j.athoracsur.2004.02.089
   Schimmer C, 2008, THORAC CARDIOV SURG, V56, P200, DOI 10.1055/s-2008-1038386
   Segers Patrique, 2005, Interact Cardiovasc Thorac Surg, V4, P555, DOI 10.1510/icvts.2005.112714
   Singh Kimberly, 2011, Semin Plast Surg, V25, P25, DOI 10.1055/s-0031-1275168
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
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   Vos RJ, 2012, EUR J CARDIO-THORAC, V42, pE53, DOI 10.1093/ejcts/ezs404
NR 13
TC 11
Z9 14
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2013
VL 17
IS 1
BP 85
EP 89
DI 10.1093/icvts/ivt078
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 170NI
UT WOS:000320858900022
PM 23529753
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Moiemen, NS
   Yarrow, J
   Kamel, D
   Kearns, D
   Mendonca, D
AF Moiemen, Naiem S.
   Yarrow, Jeremy
   Kamel, Dia
   Kearns, Daniel
   Mendonca, Derek
TI Topical negative pressure therapy: Does it accelerate neovascularisation
   within the dermal regeneration template, Integra? A prospective
   histological in vivo study
SO BURNS
LA English
DT Article
DE Integra; Topical negative pressure; Skin substitutes; Histology,
   Vascularisation; Dermal regeneration template
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; CHRONIC WOUNDS;
   SUBATMOSPHERIC PRESSURE; ANGIOGENESIS; DRESSINGS; MECHANISM; DEVICE;
   TRIAL
AB Background: The use of topical negative pressure (TNP) dressings with dermal regeneration template (DRT), Integra, has improved outcomes and simplified aftercare. Previous clinical studies have suggested accelerated vascularisation; with a reduction in the duration of the 1st stage after the application of Integra, from 2 to 4 weeks to as little as 4 days, but with no histological evidence. However, histological studies, without TNP, have shown that vascularisation occurs between the second and the fourth week. This study set out to examine histologically the rate of DRT neovascularisation when combined with TNP.
   Methods: Eight patients with nine reconstruction sites were enlisted. Unmeshed Integra and fibrin sealant to promote adherence were used. TNP was applied for the duration between the 1st and the 2nd stages. Patients underwent serial biopsies on days 7, 14, 21 and 28 post-application. The biopsies were stained with H&E and endothelial markers CD31 and CD34. Template vascularisation was assessed as a percentage of the template depth in which patent, canalised vascular channels could be demonstrated.
   Results: The median percentage of the template depth which demonstrated canalised channels was 0%, 20%, 61% and 80% for days, 7, 14, 21 and 28, respectively.
   Conclusion: The application of TNP dressings to dermal templates can reduce shearing forces, restrict seroma and haematoma formation, simplify wound care and improve patient tolerance. However, this study could not demonstrate that TNP accelerates neovascularisation as verified by the presence of histologically patent vascular channels. Crown Copyright (C) 2010 Published by Elsevier Ltd and ISBI. All rights reserved.
C1 [Moiemen, Naiem S.; Yarrow, Jeremy; Mendonca, Derek] Univ Hosp Birmingham NHS Fdn Trust, Midlands Burn Ctr, Birmingham, W Midlands, England.
   [Kamel, Dia; Kearns, Daniel] Univ Birmingham, Dept Histopathol, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham
RP Moiemen, NS (通讯作者)，Univ Hosp Birmingham NHS Fdn Trust, Queen Elizabeth Med Ctr, Birmingham, W Midlands, England.
EM nmoiemen@aol.com
OI Moiemen, Naiem/0000-0003-0836-5138; Mendonca, Derek
   Amith/0000-0002-7861-1966; Kearns, Daniel/0009-0005-3513-2112
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Baldwin C, 2009, ANN PLAS SURG, V62, P92, DOI 10.1097/SAP.0b013e31817762fd
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
   Fabian TS, 2000, AM SURGEON, V66, P1136
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   Jeschke MG, 2004, PLAST RECONSTR SURG, V113, P525, DOI 10.1097/01.PRS.0000100813.39746.5A
   McEwan W, 2004, BURNS, V30, P259, DOI 10.1016/j.burns.2003.11.011
   Moiemen NS, 2001, PLAST RECONSTR SURG, V108, P93, DOI 10.1097/00006534-200107000-00015
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   Potter MJ, 2008, BURNS, V34, P164, DOI 10.1016/j.burns.2007.06.020
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
   STERN R, 1990, Journal of Burn Care and Rehabilitation, V11, P7, DOI 10.1097/00004630-199001000-00003
   Ubbink DT, 2008, BRIT J SURG, V95, P685, DOI 10.1002/bjs.6238
NR 18
TC 43
Z9 48
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD SEP
PY 2010
VL 36
IS 6
BP 764
EP 768
DI 10.1016/j.burns.2010.04.011
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 642CW
UT WOS:000281182100004
PM 20494522
DA 2026-07-24
ER

PT J
AU Amin, AI
   Shaikh, IA
AF Amin, Amin Ibrahim
   Shaikh, Irshad A.
TI Topical negative pressure in managing severe peritonitis: A positive
   contribution?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Severe peritonitis; Open abdomen; Topical negative pressure; VAC (R)
   Abdominal Dressing System; VAC (R) GranuFoam (R)
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; TRIAL COMPARING
   POLYGLACTIN-910-MESH; VASCULAR SURGICAL-PATIENTS; RANDOMIZED-TRIAL;
   PLANNED REOPERATIONS; COMPARTMENT SYNDROME; WOUND CLOSURE; 258 TRAUMA;
   MANAGEMENT
AB AIM: To assess the use of topical negative pressure (TNP) in the management of severe peritonitis.
   METHODS: This is a four-year prospective analysis from January 2005 to December 2008 of 20 patients requiring TNP following laparotomy for severe peritonitis.
   RESULTS: There were 11 males with an average age of (59.3 +/- 3.95) years. Nine had a perforated viscus, five had anastomotic leaks, three had iatrogenic bowel injury, and a further three had severe pelvic inflammatory disease. TNP and the VAC (R) Abdominal Dressing System were initially used. These were changed every two to three days. Abdominal closure was achieved in 15/20 patients within 4.53 +/- 1.64 d. One patient required relaparotomy due to residual sepsis. Two patients with severe faecal peritonitis due to perforated diverticular disease received primary anastomosis at second look laparotomy, as sepsis and their general condition improved. In the remaining 5/20 cases, the abdomen was left open due to bowel oedema and or abdominal wall oedema. Dressing was switched to TNP and VAC (R) GranuFoam (R). Three of the five patients returned a few months later for abdominal wall reconstruction and restoration of intestinal continuity. Two patients developed intestinal fistulae. All 20 patients survived.
   CONCLUSION: The use of TNP is safe. Further studies are needed to assess its value in managing these difficult cases. (C) 2009 The WJG Press and Baishideng. All rights reserved.
C1 [Amin, Amin Ibrahim] Queen Margaret Hosp, Dept Surg, Dunfermline KY12 0SU, Fife, Scotland.
   [Shaikh, Irshad A.] Royal Infirm Edinburgh NHS Trust, Edinburgh EH16 4SA, Midlothian, Scotland.
C3 Royal Infirmary of Edinburgh; University of Edinburgh
RP Amin, AI (通讯作者)，Queen Margaret Hosp, Dept Surg, Dunfermline KY12 0SU, Fife, Scotland.
EM ibrahim.amin@faht.scot.nhs.uk
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NR 23
TC 44
Z9 49
U1 0
U2 1
PU W J G PRESS
PI BEIJING
PA APT 1066, YISHOU GARDEN, NO 58, NORTH LANGXINZHUANG RD, PO BOX 2345,
   BEIJING 100023, PEOPLES R CHINA
SN 1007-9327
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 21
PY 2009
VL 15
IS 27
BP 3394
EP 3397
DI 10.3748/wjg.15.3394
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 474EJ
UT WOS:000268265000008
PM 19610140
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Jidéus, L
   Liss, A
   Ståhle, E
AF Jideus, Lena
   Liss, Anders
   Stahle, Elisabeth
TI Patients with sternal wound infection after cardiac surgery do not
   improve their quality of life
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE Sternal wound infection; cardiac operation; quality of life; SF-36
ID VACUUM-ASSISTED CLOSURE; THORACIC ARTERY GRAFTS; RISK-FACTORS;
   BLOOD-FLOW; COMPLICATIONS; STERNOTOMY; MEDIASTINITIS; SURVIVAL
AB Objectives. Sternal wound infection after cardiac operations leave physical, cosmetic and mental scar i.e. low quality of life (QoL). To better understand and evaluate health related to QoL we used SF-36 and also analysed if there were any different outcome in SWI subgroups due to different surgical techniques. Design. Between January 1, 1998 and June 30, 2002 a total of 97 patients developed SWI at our department. The patients were followed up in terms of survival by computerised linkage to a continuously updated population register. On January 1, 2003, 84 patients could be identified as being alive and constituted the study group (SWI group) and compared with 42 patients prior to coronary artery bypass grafting (CABG) and evaluated one year postoperative (CABG group), and matched for time of the operation, age and sex. Results. The median follow-up time after cardiac surgery was 20 months (range 7-40). Late mortality was 13.4% (13/97 patients) with the median time of 5 months (range 0.5-26) postoperative. The response rate was 86.9% and SF-36 showed that SWI patients deviated significantly from the normative data for the general Swedish population. QoL for the SWI patients was comparable to QoL assessed prior to cardiac surgery i.e. the CABG group. The different surgical techniques used were comparable as they did not affect the outcome of QoL. Conclusions. Our results confirm that if the patients survive, SWI is a very serious complication concerning QoL. At follow up the SWI patients did not improve their QoL, with no difference in surgical technique used, although they had undergone open heart surgery.
C1 [Jideus, Lena] Univ Uppsala Hosp, Dept Thorac & Cardiovasc Surg, S-75185 Uppsala, Sweden.
   [Jideus, Lena; Stahle, Elisabeth] Univ Uppsala Hosp, Dept Surg Sci Thorac & Cardiovasc Surg, S-75185 Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University;
   Uppsala University Hospital
RP Jidéus, L (通讯作者)，Univ Uppsala Hosp, Dept Thorac & Cardiovasc Surg, S-75185 Uppsala, Sweden.
EM lena.jideus@akademiska.se
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NR 37
TC 24
Z9 29
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2009
VL 43
IS 3
BP 194
EP 200
AR PII 905968605
DI 10.1080/14017430802573098
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 447PM
UT WOS:000266203500010
PM 19031300
OA Bronze
DA 2026-07-24
ER

PT J
AU Ohye, RG
   Maniker, RB
   Graves, HL
   Devaney, EI
   Bove, EL
AF Ohye, RG
   Maniker, RB
   Graves, HL
   Devaney, EI
   Bove, EL
TI Primary closure for postoperative mediastinitis in children
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 83rd Annual Meeting of the American-Association-for-Thoracic-Surgery
CY MAY 04-07, 2003
CL BOSTON, MA
SP Amer Assoc Thorac Surg
ID STERNAL WOUND-INFECTION; MUSCLE FLAP; RISK-FACTORS; MANAGEMENT; SURGERY;
   RECONSTRUCTION; COMPLICATION; OPERATION
AB Objectives: Mediastinitis affects approximately 1% of children undergoing median sternotomy. Conventional therapy involves debridement followed by open wound care with delayed closure, days to weeks of closed suction or antimicrobial irrigation, and vacuum-assisted closure or muscle flap closure. We hypothesized that primary closure without prolonged suction or irrigation is an effective, less traumatic treatment for mediastinitis in children.
   Methods: From January 1986 to July 2002, 6705 procedures involving median sternotomy were performed at the C. S. Mott Children's Hospital, resulting in 57 cases of mediastinitis (0.85%). Cases were divided into 2 groups, with 42 cases treated with primary closure and 15 cases treated with delayed or muscle flap closure. The 42 cases of primary closure comprised the primary study group of this institutional review board-approved, retrospective analysis. Patient demographics, surgical variables, mediastinitis-related parameters, and outcomes were evaluated.
   Results: One patient had recurrent mediastinitis for an overall infection eradication rate of 97% (40/41). Three patients (7%) required re-exploration for suspected ongoing infection. Of these re-explorations, 1 patient had evidence of continued mediastinitis. The remaining 2 patients with sepsis of unclear cause had no clinical or culture evidence of recurrent infection. One of these patients ultimately died of sepsis without active mediastinitis for a hospital survival of 97% (41/42). No significant differences could be detected between the treatment successes and failures in this small cohort of patients.
   Conclusions: Simple primary closure is an effective means to treat selected cases of postoperative mediastinitis in children. The results compare favorably with other more lengthy or debilitating treatments.
C1 Univ Michigan, Div Pediat Cardiovasc Surg, Sch Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Ohye, RG (通讯作者)，F7830 Mott 0223,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM ohye@umich.edu
CR BACKER CL, 1994, ANN THORAC SURG, V57, P797, DOI 10.1016/0003-4975(94)90179-1
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NR 19
TC 25
Z9 32
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD SEP
PY 2004
VL 128
IS 3
BP 480
EP 486
DI 10.1016/j.jtcvs.2004.04.023
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 853UG
UT WOS:000223853800026
PM 15354112
OA Bronze
DA 2026-07-24
ER

PT J
AU Seong, BO
   Ahn, JY
   Yoo, J
   Ko, CS
   Min, SH
   Gong, CS
   Kim, BS
   Yoo, MW
   Yook, JH
   Choi, HJ
   Lee, IS
AF Seong, Ba Ool
   Ahn, Ji Yong
   Yoo, Juno
   Ko, Chang Seok
   Min, Sa-Hong
   Gong, Chung Sik
   Kim, Beom Su
   Yoo, Moon-Won
   Yook, Jeong Hwan
   Choi, Hee Jin
   Lee, In-Seob
TI Defect Size-Based Comparative Analysis of Treatment Modalities for
   Esophagojejunal Anastomotic Leakage Following Gastrectomy
SO JOURNAL OF GASTRIC CANCER
LA English
DT Article
DE Anastomotic leak; Gastrectomy; Treatment outcome; Conservative treatment
ID RISK-FACTORS; MANAGEMENT; RESECTION; ADENOCARCINOMA; SURVIVAL; JUNCTION;
   OUTCOMES; THERAPY; IMPACT
AB Purpose: Esophagojejunal anastomotic leakage (EJAL) represents a severe postoperative complication following total or proximal gastrectomy. Treatment strategies include conservative management, endoscopic interventions, and surgery; however, comparative data remain limited. This study aimed to compare clinical outcomes of different strategies to identify the optimal approach based on anastomotic defect size. Materials and Methods: This retrospective study reviewed 100 patients diagnosed with EJAL between January 2015 and October 2024. Patients were categorized into four groups: conservative management, endoscopic vacuum-assisted closure (E-VAC), other endoscopic treatments, and surgery. The primary outcomes were leakage duration and length of hospital stay after EJAL diagnosis, whereas the secondary outcome was time to C-reactive protein normalization. Subgroup analyses were performed according to defect size. Results: Among the 100 patients, 76 were male and 24 were female, with a mean age of 65.7 years. Conservative treatment was the most common modality (53%), followed by other endoscopic treatments (19%), E-VAC (14%), and surgery (14%). In patients with a defect size <1 cm, conservative treatment was associated with significantly shorter leakage duration (P=0.035) and earlier resumption of diet (P=0.029) compared with endoscopic treatment. Among those with defects >= 2 cm, E-VAC demonstrated the most favorable median outcomes across all variables; however, statistical significance was not achieved because of the small sample size. Conclusions: Conservative treatment appears to be the most effective treatment strategy for EJAL with anastomotic defects <1 cm. For larger defects (>= 2 cm), E-VAC may offer clinical benefit, although further studies are needed to confirm its efficacy. These findings highlight the importance of individualized treatment selection based on defect size.
C1 [Seong, Ba Ool; Yoo, Juno; Ko, Chang Seok; Min, Sa-Hong; Gong, Chung Sik; Kim, Beom Su; Yoo, Moon-Won; Yook, Jeong Hwan; Lee, In-Seob] Univ Ulsan, Asan Med Ctr, Div Gastrointestinal Surg, Dept Surg,Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Seong, Ba Ool; Ahn, Ji Yong] Dongnam Inst Radiol & Med Sci, Canc Ctr, Dept Surg, Div Gastrointestinal Surg, Busan, South Korea.
   [Ahn, Ji Yong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea.
   [Choi, Hee Jin] Asan Med Ctr, Dept Clin Epidemiol & Biostat, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Korea Institute of
   Radiological & Medical Sciences; University of Ulsan; Asan Medical
   Center; University of Ulsan; Asan Medical Center
RP Lee, IS (通讯作者)，Univ Ulsan, Asan Med Ctr, Div Gastrointestinal Surg, Dept Surg,Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM inseoblee77@gmail.com
RI Gong, chung sik/JCD-7106-2023; Ahn, Ji Yong/AGO-1695-2022
OI Ahn, Ji Yong/0000-0002-0030-3744
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [RS-2023-KH140182]
FX Funding This research was supported by a grant of the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI) , funded by the Ministry of Health & Welfare, Republic
   of Korea (grant number: RS-2023-KH140182)
CR Amin MB, 2017, AJCC CANC STAGING MA, V8th
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU KOREAN GASTRIC CANCER ASSOC
PI SEOUL
PA GWANGHWAMUN OPCIA BLDG 1616, 163 SINMUN-RO 1-GA, JONGNO-GU, SEOUL,
   110-999, SOUTH KOREA
SN 2093-582X
EI 2093-5641
J9 J GASTRIC CANCER
JI J. Gasric Cancer
PD APR
PY 2026
VL 26
IS 2
BP 295
EP 306
DI 10.5230/jgc.2026.26.e20
PG 12
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA GG1IW
UT WOS:001735590900012
PM 41942361
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Forrester, JD
   Faliks, B
   Cardarelli, C
   Choudhry, MS
   Patel, B
   Ricaurte, D
   Sarani, B
   Sfakianos, M
   Kartiko, S
   Huston, JM
AF Forrester, Joseph D.
   Faliks, Bradley
   Cardarelli, Cassandra
   Choudhry, Muhammad Saad
   Patel, Bhavik
   Ricaurte, Daniel
   Sarani, Babak
   Sfakianos, Maria
   Kartiko, Susan
   Huston, Jared M.
TI Chest Wall Injury Society Recommendations for Management of Surgical
   Site or Implant-Related Infections After Surgical Stabilization of
   Traumatic Rib or Sternal Fractures
SO SURGICAL INFECTIONS
LA English
DT Article
DE antibiotic agents; implant; infection; rib fractures; surgery; trauma
ID QUALITY-OF-LIFE; FLAIL CHEST; INTERNAL-FIXATION; HARDWARE; OUTCOMES;
   PAIN
AB Background: Surgical stabilization of rib fractures (SSRF) and surgical stabilization of sternal fractures (SSSF) involves open reduction and internal fixation of fractures with an implantable titanium plate to restore and maintain anatomic alignment. The presence of this foreign, non-absorbable material presents an opportunity for infection. Although surgical site infection (SSI) and implant infection rates after SSRF and SSSF are low, they present a challenging clinical entity.Methods: The Surgical Infection Society's Therapeutics and Guidelines Committee and Chest Wall Injury Society's Publication Committee convened to develop recommendations for management of SSIs or implant-related infections after SSRF or SSSF. PubMed, Embase, Web of Science and the Cochrane database were searched for pertinent studies. Using a process of iterative consensus, all committee members voted to accept or reject each recommendation.Results: For patients undergoing SSRF or SSSF who develop an SSI or an implant-related infection, there is insufficient evidence to suggest a single optimal management strategy. For patients with an SSI, systemic antibiotic therapy, local wound debridement, and vacuum-assisted closure have been used in isolation or combination. For patients with an implant-related infection, initial implant removal with or without systemic antibiotic therapy, systemic antibiotic therapy with local wound drainage, and systemic antibiotic therapy with local antibiotic therapy have been documented. For patients who do not undergo initial implant removal, 68% ultimately require implant removal to achieve source control.Conclusions: Insufficient evidence precludes the ability to recommend guidelines for the treatment of SSI or implant-related infection following SSRF or SSSF. Further studies should be performed to identify the optimal management strategy in this population.
C1 [Forrester, Joseph D.; Cardarelli, Cassandra] Stanford Univ, Dept Surg, Div Gen Surg, Stanford, CA USA.
   [Faliks, Bradley] HonorHlth Scottsdale Osborn Med Ctr, Dept Surg, Phoenix, AZ USA.
   [Choudhry, Muhammad Saad] Dow Univ Hlth Sci, Dept Surg, Karachi, Pakistan.
   [Patel, Bhavik] Gold Coast Univ Hosp, Div Trauma, Southport, Qld, Australia.
   [Ricaurte, Daniel] Hartford Hosp, Dept Acute Care Surg, Hartford, CT USA.
   [Sarani, Babak; Kartiko, Susan] George Washington Univ, Dept Surg, Ctr Trauma & Crit Care, Sch Med & Hlth Sci, Washington, DC USA.
   [Sfakianos, Maria; Huston, Jared M.] Zucker Sch Med Hofstra Northwell, Dept Surg, Div Trauma & Acute Care Surg, Hempstead, NY USA.
   [Sarani, Babak; Kartiko, Susan] Zucker Sch Med Hofstra Northwell, Dept Sci Educ, Div Trauma & Acute Care Surg, Hempstead, NY USA.
   [Forrester, Joseph D.] Stanford Univ, Dept Surg, Div Gen Surg, H3591,300 Pasteur Dr, Stanford, CA 94305 USA.
C3 Stanford University; Scottsdale Healthcare Osborn; Dow University of
   Health Sciences; Gold Coast University Hospital; Hartford Hospital;
   George Washington University; Northwell Health; Northwell Health;
   Stanford University; Stanford Medicine
RP Forrester, JD (通讯作者)，Stanford Univ, Dept Surg, Div Gen Surg, H3591,300 Pasteur Dr, Stanford, CA 94305 USA.
EM jdf1@stanford.edu
RI Faliks, Brad/NBW-8002-2025; Choudhry, Muhammad Saad/HZL-9283-2023
OI Forrester, Joseph/0000-0002-8558-6180
CR Agrafiotis AC, 2020, THORAC CARDIOV SURG, V68, P357, DOI 10.1055/s-0039-3401043
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NR 43
TC 3
Z9 4
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD JUN 1
PY 2023
VL 24
IS 5
BP 414
EP 424
DI 10.1089/sur.2023.086
EA MAY 2023
PG 11
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA I3SW8
UT WOS:000989557100001
PM 37204325
DA 2026-07-24
ER

PT J
AU Nieminen, VJ
   Jääskelainen, IH
   Eklund, AM
   Murto, ES
   Mattila, KJ
   Juvonen, TS
   Vento, AE
   Järvinen, AI
AF Nieminen, Ville J.
   Jaaskelainen, Iiro H.
   Eklund, Anne M.
   Murto, Emilia S.
   Mattila, Kimmo J.
   Juvonen, Tatu S.
   Vento, Antti E.
   Jarvinen, Asko I.
TI The Characteristics of Postoperative Mediastinitis During the Changing
   Phases of Cardiac Surgery
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID RISK-FACTORS; INFECTIONS
AB Background. Mediastinitis is a serious complication of open heart surgery associated with high mortality, considerable health care costs, and prolonged hospital stay. We examined characteristics and incidence of mediastinitis during 29 years when indications and patient material have been in a process of change.
   Methods. This was a retrospective population-based study comprising all mediastinitis patients more than 16 years of age after open heart surgery between 1990 and 2018 from a population of 1.7 million. Patient records of 50 mediastinitis patients from 2004 to 2014 were reviewed and compared with 120 patients from 1990 to 1999.
   Results. Annual mediastinitis rate varied 0% to 1.5% with a decreasing trend-from a level exceeding 1.2% to approximately 0.3%-over the study period. In 2004 to 2014 patients with mediastinitis were older, more often smokers, and more often had diabetes mellitus and renal insufficiency than in 1990 to 1999. No difference in length of hospital treatment, antibiotic prophylaxis or treatment, intensive care unit treatment, or mortality was observed between 1990 to 1999 and 2004 to 2014. Coronary artery bypass graft surgery became less common and valve replacement and hybrid operations more common among operations leading to mediastinitis. Staphylococcus aureus increased (from 25% to 56%, p = .005) whereas coagulase-negative staphylococci (46% to 23%, P < .001) and gramnegative bacteria (18% to 12%, P = .033) decreased as causative agents. Surgery for mediastinitis remained similar except introduction of vacuum-assisted closure treatment.
   Conclusions. The rate of mediastinitis decreased during these 29 years. No difference in 30-day mortality in mediastinitis was seen: 0.9% in 1990 to 1999 and 2% in 2004 to 2014. (C) 2021 by The Society of Thoracic Surgeons
C1 Univ Helsinki, Helsinki Univ Hosp, Dept Infect Dis, Inflammat Ctr, Helsinki, Finland.
   Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Helsinki University Central Hospital
RP Jääskelainen, IH (通讯作者)，Helsinki Univ Hosp, Dept Infect Dis, POB 348, Helsinki 00029, Finland.
EM iiro.jaaskelainen@hus.fi
OI Järvinen, Asko/0000-0002-1906-7665
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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NR 28
TC 8
Z9 11
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD OCT
PY 2021
VL 112
IS 4
BP 1250
EP 1256
DI 10.1016/j.athoracsur.2020.10.029
EA SEP 2021
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA WQ2CC
UT WOS:000713627000037
PM 33248999
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Tan, YB
   Li, H
   Pan, ZJ
   Zheng, Q
AF Tan, Yanbin
   Li, Hang
   Pan, Zhijun
   Zheng, Qiang
TI Modified algorithm for managing postoperative osteomyelitis following
   fracture fixation with Cierny-Mader type
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Osteomyelitis; Postoperation; Implant
ID PRESSURE WOUND THERAPY; VACUUM-ASSISTED CLOSURE
AB Background No standardized protocol has been suggested in the treatment of postoperative osteomyelitis following fracture fixation. Our team evaluates the clinical efficacy of the modified algorithm for managing postoperative osteomyelitis following fracture fixation with Cierny-Mader type. Methods Ninety-five wounds were reviewed from March 2009 to February 2016 in our hospital. Sixty-one wounds were treated by the modified algorithm as follows: stable hardware + bone not healed Cierny-Mader 1 type = remove hardware, temporary stabilize; stable hardware + bone not healed Cierny-Mader 2 type = retain hardware ; stable hardware + bone not healed Cierny-Mader for type 3 and type 4 = remove hardware, temporary stabilize/Ilizarov technique; unstable hardware + bone not healed = remove hardware, temporary stabilize/Ilizarov technique; and stable hardware + bone healed = remove hardware. Thirty-four wounds were treated by the conventional algorithm. Autodermoplasty, flap transfer, myocutaneous flap, and other methods including antibiotic irrigation and drug delivery system were used in wound repair. Results The patients treated with modified algorithm had a significantly reduced recurrence (P< 0.01) and increased results of negative bacterial cultures (P< 0.01); however, a decrease in the number of retained hardware cases was observed (P< 0.05). For those treated with tissue reconstruction, there was no significance (P> 0.05) compared with the conventional group. Conclusions The modified algorithm for the postoperative osteomyelitis following fracture fixation according to the stability of the hardware and Cierny-Mader type represents a good clinical efficacy in the management of postoperative osteomyelitis. This procedure is simple and shows promising results; more clinical evidence is needed to confirm the existing findings and optimize the treatment of postoperative osteomyelitis following fracture fixation.
C1 [Tan, Yanbin; Li, Hang; Pan, Zhijun; Zheng, Qiang] Zhejiang Univ, Dept Orthopaed Surg, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China.
C3 Zhejiang University
RP Tan, YB (通讯作者)，Zhejiang Univ, Dept Orthopaed Surg, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China.
EM drtany@zju.edu.cn
RI Pan, Zhijun/AAD-6547-2022; Tan, Yanbin/JUF-8248-2023
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   Meloni M, 2015, WORLD J ORTHOP, V6, P387, DOI 10.5312/wjo.v6.i4.387
   Miyamura Satoshi, 2016, Wounds, V28, pE22
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   Ziran BH, 2007, J TRAUMA, V62, pS59, DOI 10.1097/TA.0b013e318065abbd
NR 17
TC 0
Z9 2
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD JUN 9
PY 2020
VL 15
IS 1
AR 212
DI 10.1186/s13018-020-01693-8
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA LZ9HM
UT WOS:000541529800002
PM 32517765
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mahendran, B
   Rossi, B
   Coleman, M
   Smolarek, S
AF Mahendran, B.
   Rossi, B.
   Coleman, M.
   Smolarek, S.
TI The use of Endo-SPONGE(R) in rectal anastomotic leaks: a systematic
   review
SO TECHNIQUES IN COLOPROCTOLOGY
LA English
DT Review
DE Endo-SPONGE; Vacuum therapy; Rectal cancer; Anastomotic leak
ID VACUUM-ASSISTED CLOSURE; POUCH-ANAL ANASTOMOSIS; ENDO-SPONGE TREATMENT;
   THERAPY; DRAINAGE; MANAGEMENT; RESECTION; SURGERY; EXPERIENCE; ABSCESS
AB Background The aim of this study was to assess the efficacy of an endoluminal vacuum device (Endo-SPONGE(R)) in the treatment of rectal anastomotic leaks. Methods All studies looking at endoluminal vacuum therapy with Endo-SPONGE(R) in the treatment of rectal anastomotic leaks were included. A comprehensive search was conducted as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Primary outcome was defined as the rate of total anastomotic salvage, with secondary outcomes including rate of ileostomy closure, additional transrectal closures and functional outcomes Results Sixteen studies met the inclusion criteria. There was a significant publication bias (z = 3.53, p = 0.0004). Two hundred sixty-six patients were identified. The median treatment failure rate was 11.8% (range 0-44%), with random effects model of 0.17 (95% CI 0.11-0.22). There was improvement with early therapy start (OR 3.48) and negative correlation with neoadjuvant radiotherapy (OR 0.56). Fifty-one percent of all diverting stomas were closed at the end of treatment period and 12.8% of patients required an additional trans-rectal closure of the abscess cavity. Conclusions Endo-SPONGE(R) seems to be a useful method of rectal anastomotic leak treatment in selected group of patients; however, the quality of available data is poor and it is impossible to draw a final conclusion. There is unexpected high rate of permanent ileostomy. There is a need for further assessment of this therapy with well-designed randomised or cohort studies.
C1 [Mahendran, B.; Rossi, B.; Coleman, M.; Smolarek, S.] Univ Hosp Plymouth NHS Trust, Dept Colorectal Surg, Derriford Hosp, Derriford Rd, Plymouth PL6 8DH, Devon, England.
C3 Derriford Hospital
RP Mahendran, B (通讯作者)，Univ Hosp Plymouth NHS Trust, Dept Colorectal Surg, Derriford Hosp, Derriford Rd, Plymouth PL6 8DH, Devon, England.
EM Balaji.mahendran@nhs.net
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NR 29
TC 18
Z9 20
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1123-6337
EI 1128-045X
J9 TECH COLOPROCTOL
JI Tech. Coloproctology
PD JUL
PY 2020
VL 24
IS 7
BP 685
EP 694
DI 10.1007/s10151-020-02200-1
EA MAY 2020
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA LY6JI
UT WOS:000530772000001
PM 32377984
DA 2026-07-24
ER

PT J
AU Fujii, M
   Bessho, R
   Miyagi, Y
   Nitta, T
AF Fujii, Masahiro
   Bessho, Ryuzo
   Miyagi, Yasuo
   Nitta, Takashi
TI Negative-pressure sternal wound closure with interrupted subcuticular
   suturing and a subcutaneous drain tube reduces the incidence of
   poststernotomy wound infection after coronary artery bypass grafting
   surgery
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; Coronary artery bypass surgery;
   Negative-pressure sternal wound closure; Subcutaneous closed drain tube
ID VACUUM-ASSISTED CLOSURE; SURGICAL-SITE INFECTIONS; NOSOCOMIAL
   INFECTIONS; OBESE-PATIENTS; PREVENTION; MANAGEMENT; OUTCOMES; SYSTEM;
   DEEP
AB Purposes To retrospectively evaluate the effect of negative-pressure sternal wound closure (NPSWC) with a subcutaneous closed drain tube on the sternal surgical site infection (SSI) incidence. Methods After propensity score matching of 231 patients undergoing coronary artery bypass grafting (CABG), we compared 104 pairs in the NPSWC and historical control groups. In the molecular analysis, the interleukin-6 (IL-6), basic fibroblast growth factor (b-FGF), and transforming growth factor beta 1 (TGF-beta 1) levels in the wound fluid were measured using two different reservoir types at postoperative days 2 and 7. Results NPSWC significantly reduced the SSI incidence from 10.6 to 2.9%. No mediastinitis occurred in the NPSWC group. A multivariate logistic regression analysis identified female sex (p = 0.0040) and no NPSWC (p = 0.0084) as significant risk factors for sternal SSI development. The Negative-pressure value was 49.4 +/- 4.1 and 115.5 +/- 15.2 mmHg in the standard-type (SSR) and bulb-type suction reservoirs (BSR), respectively. Given that growth factors were affected by the difference in negative pressure, the IL-6, b-FGF, and TGF-beta 1 levels were significantly higher in the BSR than in the SSR. Conclusions NPSWC using a subcutaneous closed drain tube was effective in preventing sternal SSI after CABG and may accelerate wound healing even when both internal thoracic arteries are harvested. Clinical registration number University Hospital Medical Information Network Clinical Trials Registry, registration number: UMIN000037060.
C1 [Fujii, Masahiro; Bessho, Ryuzo] Chiba Hokusoh Hosp, Nippon Med Sch, Cardiavasc Surg, 1715 Kamagari, Chiba 2701694, Japan.
   [Miyagi, Yasuo; Nitta, Takashi] Nippon Med Sch, Cardiavasc Surg, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1130021, Japan.
C3 Nippon Medical School; Nippon Medical School
RP Fujii, M (通讯作者)，Chiba Hokusoh Hosp, Nippon Med Sch, Cardiavasc Surg, 1715 Kamagari, Chiba 2701694, Japan.
EM m-fujii@nms.ac.jp
FU Nippon Medical School Alumni Association Medical Research Grant
FX This work was supported by the Nippon Medical School Alumni Association
   Medical Research Grant.
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NR 31
TC 7
Z9 8
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD MAY
PY 2020
VL 50
IS 5
BP 475
EP 483
DI 10.1007/s00595-019-01912-8
EA NOV 2019
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LH1BJ
UT WOS:000495186700001
PM 31705266
DA 2026-07-24
ER

PT J
AU Riechelmann, F
   Kaiser, P
   Arora, R
AF Riechelmann, F.
   Kaiser, P.
   Arora, R.
TI Primary soft tissue management in open fracture
SO OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE
LA German
DT Article
DE Wound closure; Wound infection; Debridement; Irrigation; Lavage
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; SURGICAL DEBRIDEMENT;
   PRIMARY CLOSURE; DEEP INFECTION; OPEN INJURIES; LIMB SALVAGE; TRAUMA;
   METAANALYSIS; SCORE
AB ObjectiveDebridement of soft tissue and bone in an open fracture situation to minimize infection risk and achieve primary skin closure, or to provide conditions for early soft tissue coverage.IndicationsIndications are Gustilo-Anderson gradeI-IIIA-C open fractures.ContraindicationsContraindications are injuries requiring amputation, burns, and life-threatening injuries which make appropriate treatment temporarily impossible.Surgical techniqueRemoval of gross contamination and macroscopic contaminants; debridement of the wound; complete resection of contaminated and dirty tissue; sparse step-by-step resection of contaminated or non-vital wound and bone margins until vital, bleeding tissue begins; low-pressure irrigation with isotonic irrigation fluid; diagnostic biopsies for microbiological testing; reduction of dead space by interpositioning of muscle or cement spacers loaded with local antibiotics; primary wound closure if tension-free closure possible; otherwise, if resources and knowhow permit and satisfactory clean debridement was achieved, local flap; if flap impossible, debridement not satisfactory, secondary tissue necrosis likely, potential remaining contamination or contamination with fecal matter, then vacuum-assisted closure therapy.Postoperative managementWound inspection on the second postoperative day, generous indication for second-look surgery after 36-48h, wound inspection on the second postoperative day, wound inspection every other day, primary antibiotic prophylaxis with afirst- or second-generation cephalosporin (e.g., cefuroxime), and adaptation of antibiotic therapy according to susceptibility screening.ResultsInfection rates of 2-4.7% are reported for immediate primary wound closure in Gustilo-Anderson gradeI, II, and IIIA open fractures. For Gustilo-Anderson gradeIIIB, good wound healing, bony consolidation, and no need for secondary surgery was reported in 86.7% when primary wound closure was achieved.
C1 [Riechelmann, F.; Kaiser, P.; Arora, R.] Med Univ Innsbruck, Univ Klin Unfallchirurg, Anichstr 35, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Riechelmann, F (通讯作者)，Med Univ Innsbruck, Univ Klin Unfallchirurg, Anichstr 35, A-6020 Innsbruck, Austria.
EM felix.riechelmann@tirol-kliniken.at
OI Arora, Rohit/0000-0002-4843-7303
FU University of Innsbruck; Medical University of Innsbruck
FX Open access funding provided by University of Innsbruck and Medical
   University of Innsbruck.
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NR 48
TC 12
Z9 22
U1 0
U2 6
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0934-6694
EI 1439-0981
J9 OPER ORTHOP TRAUMATO
JI Oper. Orthopade Traumatol.
PD OCT
PY 2018
VL 30
IS 5
BP 294
EP 308
DI 10.1007/s00064-018-0562-8
PG 15
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GV0WC
UT WOS:000445784500002
PM 30182178
OA hybrid
DA 2026-07-24
ER

PT J
AU Naghavi, AO
   Fernandez, DC
   Mesko, N
   Juloori, A
   Martinez, A
   Scott, JG
   Shah, C
   Harrison, LB
AF Naghavi, A. O.
   Fernandez, D. C.
   Mesko, N.
   Juloori, A.
   Martinez, A.
   Scott, J. G.
   Shah, C.
   Harrison, L. B.
TI American Brachytherapy Society consensus statement for soft tissue
   sarcoma brachytherapy
SO BRACHYTHERAPY
LA English
DT Article
DE Soft tissue sarcoma; Brachytherapy; Retroperitoneal sarcoma; Radiation
ID HIGH-DOSE-RATE; EXTERNAL-BEAM RADIOTHERAPY; LIMB-SPARING SURGERY;
   INTRAOPERATIVE RADIATION-THERAPY; PROSPECTIVE RANDOMIZED-TRIAL;
   PERIOPERATIVE INTERSTITIAL BRACHYTHERAPY; VACUUM-ASSISTED CLOSURE; PHASE
   I/II TRIAL; RETROPERITONEAL SARCOMA; LOCAL-CONTROL
AB PURPOSE: Radiation therapy represents an essential treatment option in the management of soft tissue sarcomas (STS). Brachytherapy represents an important subset of radiation therapy techniques used for STS, with evolving indications and applications. Therefore, the purpose of this guideline was to update clinicians regarding the data surrounding brachytherapy (BT) and provide recommendations for the utilization of BT in patients with STS.
   METHODS AND MATERIALS: Members of the American Brachytherapy Society with expertise in STS, and STS BT in particular, created an updated guideline for the use of BT in STS based on a literature review and clinical experience.
   RESULTS: Guidelines are presented with respect to dose and fractionation and technical features to improve outcomes and potentially reduce the risk of toxicity. Brachytherapy as monotherapy can be considered in low-risk cases or in situations where re-irradiation is being considered. Brachytherapy boost can be considered in cases at higher risk of recurrence or where BT alone cannot adequately cover the target volume. To limit wound complications, the start of BT delivery should be delayed until final wound closure, or if after immediate reconstruction, started after postoperative Day 5.
   CONCLUSIONS: The current guidelines have been created to provide clinicians with a review of the data supporting BT in the management of STS as well as providing indications and technique guidelines to ensure optimal patient selection and clinical outcomes. (C) 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
C1 [Naghavi, A. O.; Fernandez, D. C.; Harrison, L. B.] H Lee Moffitt Canc Ctr & Res Inst, Radiat Oncol, Tampa, FL USA.
   [Mesko, N.] Cleveland Clin, Dept Orthoped, Cleveland, OH 44106 USA.
   [Juloori, A.; Scott, J. G.; Shah, C.] Cleveland Clin, Dept Radiat Oncol, Taussig Canc Inst, 9500 Euclid Ave,T28, Cleveland, OH 44195 USA.
   [Martinez, A.] Michigan Hlth Care Profess, Century Oncol 21, Farmington Hills, MI USA.
C3 H Lee Moffitt Cancer Center & Research Institute; Cleveland Clinic
   Foundation; Cleveland Clinic Foundation
RP Shah, C (通讯作者)，Cleveland Clin, Dept Radiat Oncol, Taussig Canc Inst, 9500 Euclid Ave,T28, Cleveland, OH 44195 USA.
EM shahc4@ccf.org
RI Naghavi, Arash/AHB-4226-2022; Mesko, Nathan/NGR-7162-2025; Fernandez,
   Daniel/ABE-2657-2021; Scott, Jacob/H-9634-2019
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NR 226
TC 57
Z9 62
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1538-4721
EI 1873-1449
J9 BRACHYTHERAPY
JI Brachytherapy
PD MAY-JUN
PY 2017
VL 16
IS 3
BP 466
EP 489
DI 10.1016/j.brachy.2017.02.004
PG 24
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA EW1EB
UT WOS:000402231600003
PM 28342738
DA 2026-07-24
ER

PT J
AU Heit, YI
   Lancerotto, L
   Mesteri, I
   Ackermann, M
   Navarrete, MF
   Nguyen, CT
   Mukundan, S
   Konerding, MA
   Del Vecchio, DA
   Orgill, DP
AF Heit, Yvonne I.
   Lancerotto, Luca
   Mesteri, Ildiko
   Ackermann, Maximilian
   Navarrete, Maria F.
   Nguyen, Collin T.
   Mukundan, Srinivasan, Jr.
   Konerding, Moritz A.
   Del Vecchio, Daniel A.
   Orgill, Dennis P.
TI External Volume Expansion Increases Subcutaneous Thickness, Cell
   Proliferation, and Vascular Remodeling in a Murine Model
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; AUTOLOGOUS FAT; BREAST RECONSTRUCTION;
   ADIPOSE-TISSUE; PRE-EXPANSION; AUGMENTATION; TRANSPLANTATION;
   LYMPHEDEMA; WOUNDS
AB Background: Fat grafting is a powerful tool for soft-tissue reconstruction; however, the science behind recipient bed preparation has not been thoroughly explored. External volume expansion using suction before fat grafting has been used clinically to improve reliability and consistency of graft survival. The authors developed a murine model to investigate the underlying mechanism of external volume expansion.
   Methods: The authors created an external volume expansion device using a soft-silicone dome connected to a vacuum source (25 mmHg) to treat the dorsum of mice, and the response was compared with treatment with an occlusive dressing. Treated areas were monitored with magnetic resonance imaging. Remodeling of microvasculature was studied with corrosion casting on day 7. Effects on tissue thickness, number of adipocytes, cell proliferation, and blood vessel density were analyzed at 28 days.
   Results: Macroscopic analysis showed tissue swelling at sites treated with the external volume expansion device by 21 days, without skin damage. On day 28, external volume expansion increased the thickness of the subcutaneous fat layer twofold, consistent with magnetic resonance imaging observations. The proliferation rate in the subcutaneous layer of expansion-treated areas increased twofold, with a net 2.2-fold increase in number of adipocytes in columns; remodeling of the vessels network occurred, with reorientation and increase of vessel diameters shown by corrosion casting and 1.9-fold augmentation of vessels density.
   Conclusions: External volume expansion applied to mouse integument induces highly proliferative and vascularized subcutaneous tissue. Recipient-site preparation using external volume expansion devices may be a promising tool to enhance cell and tissue engraftment. (Plast. Reconstr. Surg. 130: 541, 2012.)
C1 [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, 75 Francis St, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
   Univ Magdeburg, Dept Plast Aesthet & Hand Surg, Magdeburg, Germany.
   Univ Padua, Inst Plast Surg, Padua, Italy.
   Univ Vienna, Clin Inst Pathol, Vienna, Austria.
   Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Funct & Clin Anat, Mainz, Germany.
   Pontificia Univ Catolica Chile, Dept Surg, Santiago, Chile.
   Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cambridge, MA 02138 USA.
   Harvard Univ, Sch Med, Back Bay Plast Surg, Cambridge, MA 02138 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Otto von Guericke University; University of Padua;
   University of Vienna; Johannes Gutenberg University of Mainz; Pontificia
   Universidad Catolica de Chile; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Lancerotto, Luca/A-5745-2013; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR Andrikopoulou E, 2011, CURR MOL MED, V11, P218, DOI 10.2174/156652411795243414
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NR 24
TC 80
Z9 85
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2012
VL 130
IS 3
BP 541
EP 547
DI 10.1097/PRS.0b013e31825dc04d
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 001KB
UT WOS:000308458300040
PM 22929239
DA 2026-07-24
ER

PT J
AU Biefer, HRC
   Sündermann, SH
   Emmert, MY
   Rancic, Z
   Salzberg, SP
   Grünenfelder, J
   Falk, V
   Plass, AR
AF Biefer, Hector Rodriguez Cetina
   Suendermann, Simon H.
   Emmert, Maximilian Y.
   Rancic, Zoran
   Salzberg, Sacha P.
   Gruenenfelder, Juerg
   Falk, Volkmar
   Plass, Andre R.
TI Negative microbiological results are not mandatory in deep sternal wound
   infections before wound closure
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 25th Annual Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY OCT 01-05, 2011
CL Lisbon, PORTUGAL
SP European Assoc Cardio Thorac Surg (EACTS), European Cardiovascular Res Ctr (CERC)
DE Vacuum-assisted therapy; Deep sternal wound infection; Microbiological
   findings; Wound closure
ID VACUUM-ASSISTED CLOSURE; BYPASS GRAFT-SURGERY; RISK-FACTORS;
   POSTSTERNOTOMY MEDIASTINITIS; THERAPY; MANAGEMENT; COST
AB To define the outcome of treatment for deep sternal wound infections (DSWIs) using direct wound closure (DC) or vacuum-assisted therapy (VAT) based on negative vs. positive microbiological results.
   Between 1999 and 2008, 7746 patients underwent median sternotomy for cardiac surgery at our institution. Patients were screened for DSWI and out of the cohort 159 were identified (2%). These patients were treated, either using DC or VAT with delayed wound closure. Outcomes were retrospectively analysed to determine the effect of negative cultures at the time of closure.
   The indication for sternotomy was CABG 51%, isolated valve 18%, CABG/valve 18% and other related cardiovascular procedures 14%. Sixty-five percent of the wound infections was diagnosed during rehabilitation period. One hundred and five (66%) patients were treated with VAT vs. 54 (34%) patients with direct closure. Coagulase negative staphylococci were found in 48% of bacterial cultures. In 75% of the patients, the microbiological results were positive at time of wound closure (69.2% VAT vs. 87.0% direct closure, P = 0.014). Out of 159 patients, 5.0% were with positive microbiological results at the time of closure readmitted vs. 5.1% with negative microbiological results (P = 1.0). Patients with VAT stayed significantly longer in the hospital (mean 21 +/- 16 vs. 13 +/- 12, P = 0.002).
   Negative microbiological results are not mandatory before wound closure, as the rate of readmissions for recurrence of infection showed no difference between groups. Our results also suggest that shortening of VAT despite positive microbiological results may be feasible.
C1 [Biefer, Hector Rodriguez Cetina] Univ Zurich Hosp, Dept Cardiovasc Surg, Cardiovasc Surg Clin, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital
RP Biefer, HRC (通讯作者)，Univ Zurich Hosp, Dept Cardiovasc Surg, Cardiovasc Surg Clin, Ramistr 100, CH-8091 Zurich, Switzerland.
EM hector.rodriguez@usz.ch
RI Sündermann, PD/ABB-4333-2021
OI Falk, Volkmar/0000-0002-7911-8620; Roiguez Cetina Biefer,
   Hector/0000-0002-5855-8993
CR Al-Zaru IM, 2010, J CLIN NURS, V19, P1873, DOI 10.1111/j.1365-2702.2010.03193.x
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NR 25
TC 18
Z9 21
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD AUG
PY 2012
VL 42
IS 2
BP 306
EP 310
DI 10.1093/ejcts/ezr326
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 973NA
UT WOS:000306365600025
PM 22290924
OA Green Accepted, Bronze
DA 2026-07-24
ER

PT J
AU Lin, HW
   Richmon, JD
   Emerick, KS
   de Venecia, RK
   Zeitels, SM
   Faquin, WC
   Lin, DT
AF Lin, Harrison W.
   Richmon, Jeremy D.
   Emerick, Kevin S.
   de Venecia, Ronald K.
   Zeitels, Steven M.
   Faquin, William C.
   Lin, Derrick T.
TI Malignant transformation of a highly aggressive human papillomavirus
   type 11-associated recurrent respiratory papillomatosis
SO AMERICAN JOURNAL OF OTOLARYNGOLOGY
LA English
DT Article; Proceedings Paper
CT Combined Sections Meeting of the Southern/Middle Triological-Society
CY JAN 08-11, 2009
CL Bonita Springs, FL
SP Triol Soc
ID VACUUM-ASSISTED CLOSURE
AB Objective: The objective is to present an uncommon case of squamous cell carcinoma (SCC) arising from extensive recurrent respiratory papillomatosis (RRP) involving the upper and lower airway and temporal bone.
   Study Design: This is a case report and a review of the literature.
   Methods: We describe a case of a 24-year old woman with a history of human papillomavirus (HPV) type 11 since childhood originating in the larynx and trachea, then progressing to involve the distal pulmonary alveoli and right middle ear through the eustachian tube. Papillomatous growth was treated with multiple surgeries including laser cytoreduction of laryngotracheal papillomatosis and radical mastoidectomy, followed by a trial of chemotherapy. Despite this aggressive treatment regimen, papillomatous growth progressed with recurrence in the right eustachian tube, middle ear, and mastoid eventually extending to involve the calvaria and scalp.
   Results: The patient underwent a composite resection of involved tissues, including the scalp, auricle, and lateral temporal bone, with reconstruction using a latissimus dorsi free flap. Final pathologic analysis revealed an extensive infiltrative well-differentiated SCC arising from the papilloma. A review of the literature on aggressive respiratory papillomatosis suggests that malignant transformation of juvenile-onset RRP occurs exclusively in cases positive for HPV-11.
   Conclusions: We report an unusual case of SCC originating from extensive RRP involving the airway, temporal bone, and scalp and describe the medical and surgical management. Although the incidence of juvenile-onset RRP transformation to SCC is very low, the presence of HPV-11 as a risk factor for malignant transformation of RRP is becoming evident. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Lin, Harrison W.; Emerick, Kevin S.; de Venecia, Ronald K.; Lin, Derrick T.] Massachusetts Eye & Ear Infirm, Dept Otolaryngol Head & Neck Surg, Boston, MA 02114 USA.
   [Lin, Harrison W.; Emerick, Kevin S.; de Venecia, Ronald K.; Lin, Derrick T.] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02115 USA.
   [Richmon, Jeremy D.] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Baltimore, MD USA.
   [Zeitels, Steven M.] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Dept Surg, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02115 USA.
   [Faquin, William C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   Eye & Ear Infirmary; Harvard University; Harvard Medical School; Johns
   Hopkins University; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Lin, HW (通讯作者)，Massachusetts Eye & Ear Infirm, Dept Otolaryngol Head & Neck Surg, 243 Charles St, Boston, MA 02114 USA.
EM harrison_lin@meei.harvard.edu
RI Richmon, Jeremy/ABI-4295-2020
OI Richmon, Jeremy/0000-0002-6588-6549
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Cook JR, 2000, MODERN PATHOL, V13, P914, DOI 10.1038/modpathol.3880164
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   Rabah R, 2001, PEDIATR DEVEL PATHOL, V4, P68, DOI 10.1007/s100240010105
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   Vidrine DM, 2005, OTOLARYNG HEAD NECK, V133, P403, DOI 10.1016/j.otohns.2005.04.028
NR 8
TC 36
Z9 42
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0196-0709
J9 AM J OTOLARYNG
JI Am. J. Otolaryngol.
PD JUL-AUG
PY 2010
VL 31
IS 4
BP 291
EP 296
DI 10.1016/j.amjoto.2009.02.019
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA 624UR
UT WOS:000279847700017
PM 20015762
DA 2026-07-24
ER

PT J
AU Li, KY
   Liu, P
AF Li, Keya
   Liu, Peng
TI Clinical Efficacy of Combined Internal and External Fixation with
   Nanosilver Dressing and Vacuum Closure for Gustilo Type I/II Open Tibial
   Fractures
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID PRESSURE WOUND THERAPY; SILVER NANOPARTICLES; ASSISTED CLOSURE;
   INFECTION-RATE; ACTIVE SILVER; COMPLICATIONS; MANAGEMENT; OUTCOMES
AB Gustilo type I and II open tibial fractures (OTFs) are associated with significant soft tissue injury and a high risk of infection, often resulting in prolonged healing and postoperative complications when treated using conventional internal or external fixation. This study introduces a clinically validated approach that integrates nanosilver antibacterial dressing (NSAD) and vacuum-assisted closure (VAC) with closed reduction and intramedullary nail fixation (CRINF) to improve wound and fracture healing outcomes. A total of 300 patients with Gustilo type I/II OTFs were enrolled and randomly assigned into three groups (n = 100 per group): Group 1 received CRINF with conventional wound care, Group 2 received CRINF with VAC, and Group 3 received CRINF with NSAD and VAC. Clinical outcomes, including infection rate, wound and fracture healing time, hospital stay, medical cost, and postoperative pain, were compared among the groups using chi-square and ANOVA tests, with significance defined as p < 0.05. Group 3 exhibited the lowest complication rate and the most favorable recovery profile, with an average wound healing time of 41 days and a fracture healing time of 7.2 months, both significantly shorter than in the control groups (p < 0.05). The wound and fracture healing rates were 97% and 94%, respectively, while patients experienced shorter hospital stays (10-15 days), lowertotal medical costs (similar to 1500 yuan), and reduced pain levels. These findings demonstrate that combining NSAD and VAC with CRINF offers an effective and safe clinical protocol for managing Gustilo type I and II OTFs, substantially reducing postoperative complications and accelerating recovery.
C1 [Li, Keya; Liu, Peng] Hengshui Peoples Hosp, Dept Orthoped & Traumatol, Hengshui, Peoples R China.
RP Li, KY (通讯作者)，Hengshui Peoples Hosp, Dept Orthoped & Traumatol, Hengshui, Peoples R China.
EM liKeya1234@163.com
RI Li, Keya/PFJ-2068-2025
FU Key R&D Program of Hengshui City
FX This study is supported by the Key R&D Program of Hengshui City (Project
   Name: Clinical Study on the Efficacy of Negative Pressure Closed
   Drainage (VAC) Combined with Internal and External Fixation in the
   Treatment of Open Tibial Fractures) .
CR Al-Sadi O, 2020, Orthopädie und Unfallchirurgie up2date, V15, P43, DOI 10.1055/a-0662-8017
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 34
TC 0
Z9 0
U1 1
U2 2
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD NOV
PY 2025
IS 225
AR e69394
DI 10.3791/69394
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q8901
UT WOS:001635042300022
PM 41359595
DA 2026-07-24
ER

PT J
AU Lancerotto, L
   Chin, MS
   Freniere, B
   Lujan-Hernandez, JR
   Li, Q
   Vasquez, AV
   Bassetto, F
   Del Vecchio, DA
   Lalikos, JF
   Orgill, DP
AF Lancerotto, Luca
   Chin, Michael S.
   Freniere, Brian
   Lujan-Hernandez, Jorge R.
   Li, Qiong
   Vasquez, Alessandro Valderrama
   Bassetto, Franco
   Del Vecchio, Daniel A.
   Lalikos, Janice F.
   Orgill, Dennis P.
TI Mechanisms of Action of External Volume Expansion Devices
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PEDICLED FAT FLAP; AUTOLOGOUS FAT;
   ADIPOSE-TISSUE; CELL-PROLIFERATION; BREAST RECONSTRUCTION; MURINE MODEL;
   FOLLOW-UP; IN-VITRO; ADIPOGENESIS
AB Background: External volume expansion by suction has been proposed to improve the survival of fat grafting by preparing the recipient site. In previous experimental work, external volume expansion demonstrated the capacity to stimulate cell proliferation, vessel remodeling, and adipogenesis. This study investigated possible mechanisms underlying these observed changes.
   Methods: A miniaturized external volume expansion device was applied to the dorsum of mice for 2 hours. Hypoxia during stimulation was assessed with pimonidazole hydrochloride, and tissue perfusion was measured for up to 2 days using hyperspectral imaging. Treated tissues were evaluated by microscopy for edema, inflammation, and the effects on cell proliferation and vessel remodeling.
   Results: External volume expansion-treated tissues were grossly expanded with 2 hours of stimulation, developing a macroscopic swelling that regressed slowly over the course of hours following stimulus cessation. This gross swelling was reflective of histologic signs of intense edema, persistent for at least 1 hour after external volume expansion. Tissues were hypoxic during stimulation, and hyperspectral imaging demonstrated decreased tissue content of both oxygenated and deoxygenated hemoglobin in the first hour after external volume expansion release. The onset of inflammation was already apparent by the end of stimulation and remained elevated through 2 days after external volume expansion. At this time point, epidermal and dermal cell proliferation and vascular density were significantly increased.
   Conclusion: External volume expansion sets in motion various mechanisms, including mechanical stimulation, edema, ischemia, and inflammation, that over distinct time periods maintain an environment conducive to cell proliferation and angiogenesis, which can be elicited even by a single 2-hour external volume expansion cycle.
C1 Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
   Univ Padua, Inst Plast Reconstruct & Aesthet Surg, I-35100 Padua, Italy.
   Univ Massachusetts, Sch Med, Div Plast Surg, Amherst, MA 01003 USA.
   Back Bay Plast Surg, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; University of Padua; University of
   Massachusetts System; University of Massachusetts Amherst
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Orgill, Dennis/H-7596-2019; Lancerotto, Luca/A-5745-2013
OI Orgill, Dennis/0000-0002-8279-7310; 
FU Kinetic Concepts, Inc.
FX Dr. Orgill has been an expert witness, consultant, and grant recipient
   of funding provided by Kinetic Concepts, Inc., the manufacturer of the
   device used in this study. The other authors have no financial interest
   to declare in relation to the content of this article.
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NR 44
TC 76
Z9 82
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2013
VL 132
IS 3
BP 569
EP 578
DI 10.1097/PRS.0b013e31829ace30
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 293PD
UT WOS:000329984000044
PM 23676966
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Phan, TQV
   Depner, C
   Theodorou, P
   Lefering, R
   Perbix, W
   Spilker, G
   Weinand, C
AF Phan, Truong Q. V.
   Depner, Christian
   Theodorou, Panagiotis
   Lefering, Rolf
   Perbix, Walter
   Spilker, Gerald
   Weinand, Christian
TI Failure of Secondary Wound Closure After Sternal Wound Infection
   Following Failed Initial Operative Treatment Causes and Treatment
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE deep sternal wound infection; gram-negative bacteria; wound dehiscence;
   salvage flap closure
ID OPEN-HEART SURGERY; CARDIAC-SURGERY; MUSCLE FLAPS; RISK-FACTORS;
   POSTOPERATIVE MEDIASTINITIS; RECONSTRUCTION; TRANSPOSITION; SURVIVAL;
   COMPLICATIONS; EXPERIENCE
AB Background: Patients transferred to Plastic Surgery Departments for sternum osteomyelitis have a high morbidity of about 3%. Despite several known options for sternal wound coverage and salvage operations, wound dehiscence or wound necrosis can occur, increasing patient morbidity.
   Patients and Methods: One hundred thirty-five patients admitted between January 2007 and December 2010 were evaluated in a retrospective study for wound dehiscence after salvage-wound coverage at our institution. Various flaps were applied, such as pectoralis major myocutaneous pedicled flaps, pectoralis major muscle pedicled flaps, latissimus dorsi pedicled flaps, greater omental flaps, and vertical rectus abdominis muscle and transverse rectus abdominis muscle flaps. Inclusion criteria were sternal wound infection, bacterial wound infection, previous wound debridement outside our institution, vacuum-assisted closure device wound treatment at our institution, and secondary flap closure of the sternal defect at our institution. A multivariate regression analysis was performed.
   Results: One hundred thirty patients met the inclusion criteria. In all patients, bacterial wound colonization was shown. Forty patients showed wound dehiscence after closure at our institution. Reasons for wound dehiscence were attributed to wound size, >4 different species of bacteria colonizing the wound, gram-negative bacteria, Candida albicans, intensive care unit stay, and female gender. Interestingly, wound dehiscence was not significant correlated to obesity, smoking, atherosclerosis, renal insufficiency or type of closure influenced significantly, or necrosis.
   Conclusions: Female patients after CABG, with large sternal wounds infected with gram-negative bacteria and candida, have an 85% risk of wound dehiscence after flap coverage for sternal wound infection.
C1 Univ Hosp Cologne Merheim, Dept Plast Reconstruct & Aesthet Surg, Cologne, Germany.
   Univ Hosp Cologne Merheim, Inst Res Operat Med IFOM, Cologne, Germany.
   Univ Cologne, Dept Cardiothorac Surg, D-50931 Cologne, Germany.
   Univ Dusseldorf, Dept Cardiovasc Surg, D-40225 Dusseldorf, Germany.
C3 University of Cologne; University of Cologne; University of Cologne;
   Heinrich Heine University Dusseldorf
RP Weinand, C (通讯作者)，Univ Klin Standort Koln Merheim, Dept Plast Reconstruct & Aesthet Surg, Ostmerheimer Str 200, D-51109 Cologne, Germany.
EM phant@kliniken-koeln.de; weinandc@kliniken-koeln.de
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NR 35
TC 16
Z9 19
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2013
VL 70
IS 2
BP 216
EP 221
DI 10.1097/SAP.0b013e31823b67ec
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 076NW
UT WOS:000313964300020
PM 22274149
DA 2026-07-24
ER

PT J
AU Heit, YI
   Dastouri, P
   Helm, DL
   Pietramaggiori, G
   Younan, G
   Erba, P
   Münster, S
   Orgill, DP
   Scherer, SS
AF Heit, Yvonne I.
   Dastouri, Pouya
   Helm, Douglas L.
   Pietramaggiori, Giorgio
   Younan, George
   Erba, Paolo
   Muenster, Stefan
   Orgill, Dennis P.
   Scherer, Sandra S.
TI Foam Pore Size Is a Critical Interface Parameter of Suction-Based Wound
   Healing Devices
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR-MATRIX; CELL-PROLIFERATION; SKIN;
   ADHESION; MODEL
AB Background: Suction-based wound healing devices with open-pore foam interfaces are widely used to treat complex tissue defects. The impact of changes in physicochemical parameters of the wound interfaces has not been investigated.
   Methods: Full-thickness wounds in diabetic mice were treated with occlusive dressing or a suction device with a polyurethane foam interface varying in mean pore size diameter. Wound surface deformation on day 2 was measured on fixed tissues. Histologic cross-sections were analyzed for granulation tissue thickness (hematoxylin and eosin), myofibroblast density (alpha-smooth muscle actin), blood vessel density (platelet endothelial cell adhesion molecule-1), and cell proliferation (Ki67) on day 7.
   Results: Polyurethane foam-induced wound surface deformation increased with polyurethane foam pore diameter: 15 percent (small pore size), 60 percent (medium pore size), and 150 percent (large pore size). The extent of wound strain correlated with granulation tissue thickness that increased 1.7-fold in small pore size foam-treated wounds, 2.5-fold in medium pore size foam-treated wounds, and 4.9-fold in large pore size foam-treated wounds (p < 0.05) compared with wounds treated with an occlusive dressing. All polyurethane foams increased the number of myofibroblasts over occlusive dressing, with maximal presence in large pore size foam-treated wounds compared with all other groups (p < 0.05).
   Conclusions: The pore size of the interface material of suction devices has a significant impact on the wound healing response. Larger pores increased wound surface strain, tissue growth, and transformation of contractile cells. Modification of the pore size is a powerful approach for meeting biological needs of specific wounds. (Plast. Reconstr. Surg. 129: 589, 2012.)
C1 [Scherer, Sandra S.] Univ Lausanne Hosp, Dept Plast Surg, CH-1011 Lausanne, Switzerland.
   Harvard Univ, Brigham & Womens Hosp, Div Plast Surg, Sch Med, Cambridge, MA 02138 USA.
   Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University
RP Scherer, SS (通讯作者)，Univ Lausanne Hosp, Dept Plast Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM saja.scherer@googlemail.com
RI Münster, Stefan/D-6946-2011; Orgill, Dennis/H-7596-2019; PIETRAMAGGIORI,
   Giorgio/HJA-1920-2022
OI Münster, Stefan/0000-0002-8697-0344; Orgill, Dennis/0000-0002-8279-7310;
   Younan, George/0000-0001-8502-4850
FU Kinetic Concepts, Inc.
FX Dr. Orgill has been a consultant and an expert witness for Kinetic
   Concepts, Inc. (San Antonio, Texas), and a principal investigator on
   basic research studies on the vacuum-assisted closure device conducted
   through a grant to Brigham and Women's Hospital from Kinetic Concepts,
   Inc. The remaining authors have no financial disclosures to report.
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NR 17
TC 37
Z9 40
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD MAR
PY 2012
VL 129
IS 3
BP 589
EP 597
DI 10.1097/PRS.0b013e3182402c89
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 900ZV
UT WOS:000300932300064
PM 22090246
DA 2026-07-24
ER

PT J
AU Immer, FF
   Durrer, M
   Mühlemann, KS
   Erni, D
   Gahl, B
   Carrel, TP
AF Immer, FF
   Durrer, M
   Mühlemann, KS
   Erni, D
   Gahl, B
   Carrel, TP
TI Deep sternal wound infection after cardiac surgery: Modality of
   treatment and outcome
SO ANNALS OF THORACIC SURGERY
LA English
DT Article
ID POSTOPERATIVE MEDIASTINITIS; COMPLICATIONS
AB Background. Deep sternal wound infection is a serious and expensive complication after cardiac surgical procedures. We tried to identify risk factors for failure of vacuum-assisted sternal closure and compare the outcome and long-term quality of life (QoL) with the results obtained after sternal resection and muscle flap.
   Methods. Between January 1998 and December 2003, 5,690 patients under-went cardiac surgical procedures at our institution. Fifty-five patients who had deep sternal wound infection were identified between January 1998 and December 2003. In-hospital data were assessed and the outcome was analyzed. QoL, using the Short Form 36 Health Survey Questionnaire (SF-36), was assessed and an additional questionnaire focused on specific problems.
   Results. Overall mortality was 5.4%. Patients with successful vacuum-assisted sternal closure were younger and had fewer cumulative risk factors (chronic obstructive pulmonary disease, bilateral internal mammary artery, obesity, diabetes), than patients in whom secondary closure failed. Quality of life was better among patients with secondary vacuum-assisted closure than among patients with musculocutaneous flap. Independently of the modality of treatment, pain was not a serious problem reported by the patients during the follow-up.
   Conclusions. We conclude that preservation of the sternum should be the principal aim of surgical treatment in patients with deep sternal wound infection. Early diagnosis, aggressive surgical treatment by debridement, and the use of vacuum-assisted systems allows us to achieve a good long-term result with nearly normal QoL. Resection and musculocutaneous flap is a therapeutic option for high-risk patients, providing a safe, effective control of the infection, and it leads to acceptable results in terms of pain control and QoL.
C1 Univ Hosp Bern, Dept Cardiovasc Surg, Inselspital, CH-3010 Bern, Switzerland.
   Univ Hosp Bern, Dept Infect Dis, Inselspital, CH-3010 Bern, Switzerland.
   Univ Hosp Bern, Div Plast Surg, Inselspital, CH-3010 Bern, Switzerland.
C3 University of Bern; University Hospital of Bern; University of Bern;
   University Hospital of Bern; University of Bern; University Hospital of
   Bern
RP Immer, FF (通讯作者)，Univ Hosp Bern, Dept Cardiovasc Surg, Inselspital, CH-3010 Bern, Switzerland.
EM franzimmer@yahoo.de
RI Carrel, Thierry/AAI-5910-2021
OI Gahl, Brigitta/0000-0001-8123-0438
CR BLANCHARD A, 1995, EUR J CARDIO-THORAC, V9, P153, DOI 10.1016/S1010-7940(05)80064-8
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NR 21
TC 68
Z9 79
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-4975
EI 1552-6259
J9 ANN THORAC SURG
JI Ann. Thorac. Surg.
PD SEP
PY 2005
VL 80
IS 3
BP 957
EP 961
DI 10.1016/j.athoracsur.2005.03.035
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 961TC
UT WOS:000231683700030
PM 16122463
OA Bronze
DA 2026-07-24
ER

PT J
AU Moreno, CF
   Arenas, JR
   Riquelme, PR
AF Moreno, Catalina Frey
   Arenas, Joaquin Ramirez
   Riquelme, Pablo Ruiz
TI Update on the Initial Management of Open Fractures for General
   Practitioners and Specialists: A Scoping Review of the Literature
SO REVISTA MEDICA DE CHILE
LA Spanish
DT Review
DE Anti-Bacterial Agents; Emergency Service; Hospital; Fractures; Open;
   Traumatology
ID TRAUMA SOCIETY CLASSIFICATION; ANTIBIOTIC-PROPHYLAXIS; RISK-FACTORS;
   INFECTION
AB Open fractures represent a significant public health burden due to the high risk of infection, sequelae, and mortality. Initial management is crucial to prevent or reduce these complications. Aim: Describe the current options for initial management of open fractures in the emergency department by general practitioners and specialists. Methods: A scoping review of open fracture management was conducted between October and November 2024, using MESH terms in PubMed and SCIELO in English and Spanish. Articles from the last 5 years (2019-2024) were included that address the pillars of emergency department management: early antibiotic therapy, pain management, immobilization, and debridement. Results: Of 2,883 articles retrieved from PubMed and SCIELO, 30 studies were included. The mainstays of treatment remain as follows: early antibiotic therapy, pain management, immobilization, and debridement. Discussion: Antibiotic therapy should be early, ideally within 60 minutes. Surgical cleaning within 24 hours of the injury according to the fracture characteristics. Early wound closure and pain management associated with alignment and immobilization and/or fixation. Furthermore, the use of local antibiotic therapy or vacuum-assisted-closure (VAC) by the specialist should be considered. Conclusions: General practitioners should know the timing of antibiotic administration and debridement, should manage pain with medications and immobilization of the fracture, and prescribe tetanus prophylaxis as needed. The specialist should ensure surgical cleaning and wound closure, considering the use of local antibiotics such as VAC to improve the patient's prognosis. Up-to-date and protocol-based management of this condition is important for preventing morbidity and mortality.
C1 [Moreno, Catalina Frey] Univ Desarrollo, Escuela Med, Santiago, Chile.
   [Arenas, Joaquin Ramirez; Riquelme, Pablo Ruiz] Univ Finis Terrae, Escuela Med, Santiago, Chile.
   [Riquelme, Pablo Ruiz] Dept Traumatol Clin Las Condes, Unidad Cirugia Tobillo & Pie, Santiago, Chile.
   [Riquelme, Pablo Ruiz] Dept Traumatol Hosp Clin Florida, Unidad Cirugia Tobillo & Pie, Santiago, Chile.
C3 Universidad del Desarrollo; Universidad Finis Terrae; Clinica Las Condes
RP Riquelme, PR (通讯作者)，Dept Ortopedia & Traumatol, Unidad Cirugia Tobillo & Pie, Estoril 450, Las Condes, Chile.
EM pabloruizr@gmail.com
RI Ruiz Riquelme, Pablo/LLL-8737-2024
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NR 47
TC 0
Z9 0
U1 4
U2 4
PU SOC MEDICA SANTIAGO
PI SANTIAGO 9
PA BERNARDA MORIN 488 PROVIDENCIA, CASILLA 168 CORREO 55, SANTIAGO 9,
   00000, CHILE
SN 0034-9887
EI 0717-6163
J9 REV MED CHILE
JI Rev. Medica Chile
PD FEB
PY 2026
VL 154
IS 2
BP 246
EP 258
DI 10.4067/s0034-98872026000200246
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FC2HF
UT WOS:001715287900010
PM 42024695
OA gold
DA 2026-07-24
ER

PT J
AU Kratzer, SM
   Kümmerl, L
   Arkudas, A
   Horch, RE
AF Kratzer, Simon M.
   Kummerl, Luca
   Arkudas, Andreas
   Horch, Raymund E.
TI The Role of Topical Negative Pressure Therapy/Vacuum Therapy in
   Orthoplastic Surgery: NPWT, NPWTi-d and ciNPT
SO HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE
LA German
DT Review
DE Wundkonditionierung; Extremit & auml;tenrekonstruktion; Orthoplastische
   Chirurgie; wound conditioning; limb reconstruction; orthoplastic
   surgery; NPWT; ciNPT; NPWTid
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; CONSENSUS STATEMENT;
   PERIPHERAL-NERVES; TRAUMATIC WOUNDS; INSTILLATION; RECONSTRUCTION;
   MANAGEMENT; RECOMMENDATIONS; MICROSURGERY
AB Background Today, wounds of the extremities are often initially treated with localised negative pressure therapy (vacuum therapy) before bone and soft tissue reconstruction is performed. The aim is to preserve the limb and restore function and quality of life. The interdisciplinary collaboration in the treatment of neurovascular pathologies, reconstruction, and rehabilitation is known as orthoplastic reconstruction. Methods This paper outlines the milestones that have led to the development of the orthoplastic concept in limb reconstruction. In addition, the fundamental principles of modern treatment strategies, including wound bed conditioning with vacuum therapy, are discussed on the basis of relevant literature and illustrated with representative examples. Results A review of the literature shows that orthoplastic surgery developed at different times in different countries. It was only with the advent of modern techniques for skeletal stabilisation and soft tissue reconstruction that interdisciplinary concepts, including topical vacuum therapy, found their way into everyday clinical practice. Advantages of the orthoplastic approach include faster stabilisation, early soft tissue coverage, shorter hospitalisation times, reduced complication rates, and better long-term functional outcomes. Conclusion Today, localised negative pressure therapy is an indispensable tool in the orthoplastic approach. Close collaboration between plastic-reconstructive and trauma-orthopaedic surgery is essential for the timely management of reconstructive limb injuries. This approach has proven effective at specialised centres in determining the optimal time for reconstruction and improving outcomes. The earlier assumption that amputation is often more favourable has been refuted by successful orthoplastic reconstructions achieving long-term limb preservation. Today, the aim is to preserve the limb whenever possible.
C1 [Kratzer, Simon M.; Kummerl, Luca; Arkudas, Andreas; Horch, Raymund E.] Univ Klinikum Erlangen, Plast & Handchirurg Klin, Maximilianspl 2, D-91012 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Kratzer, SM (通讯作者)，Univ Klinikum Erlangen, Plast & Handchirurg Klin, Maximilianspl 2, D-91012 Erlangen, Germany.
EM simon.kratzer@uk-erlangen.de
RI Horch, Raymund/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021
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NR 70
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0722-1819
EI 1439-3980
J9 HANDCHIR MIKROCHIR P
JI Handchir. Mikrochir. Plast. Chir.
PD DEC
PY 2025
VL 57
IS 06
BP 455
EP 464
DI 10.1055/a-2706-0291
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA T4125
UT WOS:001637569100008
PM 41380693
DA 2026-07-24
ER

PT J
AU Pargätzi, GY
   Iannucci, C
   Meli, MLM
   Meili, T
   Rosati, T
   Vigani, A
AF Pargatzi, Gwenda Yui
   Iannucci, Claudia
   Meli, Marina Luisa Michela
   Meili, Theres
   Rosati, Tommaso
   Vigani, Alessio
TI Quantitative Assessment of TPE Antibody Removal and Clinical Response in
   a Dog With Severe Type III Hypersensitivity Reaction and AKI due to
   Human Albumin Administration
SO JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
LA English
DT Article
DE acute kidney injury; canine; human serum albumin; therapeutic plasma
   exchange; type III hypersensitivity reaction
ID THERAPEUTIC PLASMA-EXCHANGE; CRITICALLY-ILL; HEALTHY DOGS
AB Objective To describe the successful removal of antihuman albumin antibodies by therapeutic plasma exchange (TPE) in a dog with signs of delayed type III hypersensitivity reaction (tIIIHr), including acute kidney injury (AKI), secondary to administration of human serum albumin (HSA). Case Summary A 9-month-old dog was presented with an infected wound and treated with vacuum-assisted closure. A 28-h infusion of 20% HSA was administered to the dog postoperatively to treat persistent hypoalbuminemia during hospitalization. Seventeen days later, the dog returned for acute periorbital swelling. Clinical signs improved after standard treatment for a nonspecific allergic reaction. Five days later, the dog developed persistent vomiting, generalized subcutaneous edema, and ecchymoses on the ventral abdomen. Severe azotemia with proteinuria led to the diagnosis of acute glomerulonephritis. A delayed tIIIHr secondary to HSA administration was suspected. Two sessions of TPE were performed on consecutive days. Complete resolution of clinical signs, including azotemia, occurred after the second TPE session, and the dog was discharged 5 days later in good clinical condition. The urine protein:creatinine ratio normalized within 2 weeks of TPE. Antihuman albumin antibody concentrations were measured by indirect ELISA in the patient's plasma and in the plasma removed by TPE. New or Unique Information For the first time, antihuman albumin antibodies have been measured before and after treatment with TPE in a dog with clinical signs of delayed tIIIHr, demonstrating the effective removal of antibodies. Based on these findings, TPE could be considered for the treatment of severe tIIIHr after xenotransfusion.
C1 [Pargatzi, Gwenda Yui; Iannucci, Claudia; Rosati, Tommaso; Vigani, Alessio] Univ Zurich, Vetsuisse Fac, Dept Clin Vet Med, Div Small Anim Emergency & Crit Care, Zurich, Switzerland.
   [Meli, Marina Luisa Michela; Meili, Theres] Univ Zurich, Dept Clin Diagnost & Serv, Clin Lab, Zurich, Switzerland.
   [Meli, Marina Luisa Michela; Meili, Theres] Univ Zurich, Vetsuisse Fac, Ctr Clin Studies, Zurich, Switzerland.
C3 University of Zurich; University of Zurich; University of Zurich
RP Vigani, A (通讯作者)，Univ Zurich, Vetsuisse Fac, Dept Clin Vet Med, Div Small Anim Emergency & Crit Care, Zurich, Switzerland.
EM avigani@vetclinics.uzh.ch
OI Iannucci, Claudia/0000-0002-6976-7627
CR Almeida M, 2023, J AM ANIM HOSP ASSOC, V59, P45, DOI 10.5326/JAAHA-MS-7287
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   Zini E, 2004, AM J VET RES, V65, P964, DOI 10.2460/ajvr.2004.65.964
NR 24
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1479-3261
EI 1476-4431
J9 J VET EMERG CRIT CAR
JI J. Vet. Emerg. Crit. Care
PD SEP
PY 2025
VL 35
IS 5
BP 577
EP 583
DI 10.1111/vec.70051
EA OCT 2025
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA A1504
UT WOS:001594594700001
PM 41091457
DA 2026-07-24
ER

PT J
AU Poskevicius, A
   Meroni, M
   Fuchs, B
   Scaglioni, MF
AF Poskevicius, Audrius
   Meroni, Matteo
   Fuchs, Bruno
   Scaglioni, Mario F.
TI Combined perforator flaps and lymphatic procedures in reconstructions
   after sarcoma resection
SO MICROSURGERY
LA English
DT Article
ID SOFT-TISSUE SARCOMA; LOWER-LIMB LYMPHEDEMA; NODE TRANSFER; ANASTOMOSIS
   LVA; COMPLICATIONS PREVENTION; SUPERMICROSURGERY; MANAGEMENT; OUTCOMES;
   VESSELS; VEIN
AB BackgroundSoft tissue sarcomas are a subtle category of tumors that often require an extensive surgical resection for definitive treatment. This kind of intervention inevitably leads to large tissue damage and, when regions with rich lymphatic network are involved, postoperative complications such as lymphocele or lymphedema are quite common. In this report we present our experience with the combination of lymphatic procedures with perforator flaps for defects reconstruction and lymphatic complications preventions after sarcoma resection throughout the body.MethodsBetween 2019 and 2021, 15 patients underwent a surgical resection of soft tissue sarcoma, also including bone tissue in 2 cases, requiring soft tissue reconstruction. A perforator flap reconstruction surgery was performed in all cases. The median age was 59.8 years old (ranging 23-84), 8 patients were females and 7 were males. The lymphovenous anastomosis (LVA) surgery concept was applied to all cases, while other additional lymphatic procedures were chosen individually for every patient.ResultsAll patients were successfully treated without any perioperative complications. In 3 cases infected seroma was encountered in the acceptor site and then successfully treated by means of debridement and vacuum assisted closure (VAC) therapy. 2 patients experienced postoperative lymphedema in the acceptor site which was managed by secondary procedures. Good functional and aesthetic outcomes were achieved in all cases. The mean follow-up was 19.6 months (range 10-33 months).ConclusionsDifferent combinations of modern lymphatic procedures can be created to find the best solution and tailor the treatment to the patient's needs. Preventative measures regarding lymphatic complications can be highly effective and should be taken into consideration in every reconstructive approach following large soft tissue defects with impairment of the lymphatic network.
C1 [Poskevicius, Audrius; Meroni, Matteo; Scaglioni, Mario F.] Luzerner Kantonsspital, Dept Hand and Plast Surg, Luzern, Switzerland.
   [Poskevicius, Audrius; Scaglioni, Mario F.] Univ Lucerne, Dept Hlth Sci & Med, Luzern, Switzerland.
   [Fuchs, Bruno] Luzerner Kantonsspital, Dept Orthoped Surg, Luzern, Switzerland.
   [Scaglioni, Mario F.] Luzerner Kantonsspital, Dept Hand & Plast Surg, Spitalstr,Luzern 16, CH-6000 Luzern, Switzerland.
C3 Lucerne Cantonal Hospital; University of Lucerne; Lucerne Cantonal
   Hospital; Lucerne Cantonal Hospital
RP Scaglioni, MF (通讯作者)，Luzerner Kantonsspital, Dept Hand & Plast Surg, Spitalstr,Luzern 16, CH-6000 Luzern, Switzerland.
EM mario.scaglioni@gmail.com
RI Meroni, Matteo/HZH-2808-2023
OI Meroni, Matteo/0000-0003-4357-6985
CR Agarwal S, 2020, BREAST J, V26, P721, DOI 10.1111/tbj.13667
   Akita S, 2015, ANN PLAS SURG, V74, P573, DOI 10.1097/SAP.0000000000000513
   Cheng MH, 2018, PRS-GLOB OPEN, V6, DOI 10.1097/GOX.0000000000002056
   di Summa PG, 2020, J PLAST RECONSTR AES, V73, P995, DOI 10.1016/j.bjps.2020.01.014
   Fernebro J, 2006, BRIT J CANCER, V95, P986, DOI 10.1038/sj.bjc.6603401
   Friedmann Daniel, 2011, Sarcoma, V2011, P289673, DOI 10.1155/2011/289673
   Fujiki M, 2015, MICROSURG, V35, P536, DOI 10.1002/micr.22476
   Gentileschi S, 2017, MICROSURG, V37, P564, DOI 10.1002/micr.30142
   Gould DJ, 2018, J SURG ONCOL, V118, P736, DOI 10.1002/jso.25180
   Gronchi A, 2010, ANN SURG, V251, P506, DOI 10.1097/SLA.0b013e3181cf87fa
   Koshima I, 1996, PLAST RECONSTR SURG, V97, P397, DOI 10.1097/00006534-199602000-00018
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   Lipman K, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010092
   Mihara M, 2016, PLAST RECONSTR SURG, V138, P262, DOI 10.1097/PRS.0000000000002254
   Miyazaki T, 2021, J SURG ONCOL, V123, P698, DOI 10.1002/jso.26291
   Ozturk CN, 2016, J PLAST RECONSTR AES, V69, P1234, DOI 10.1016/j.bjps.2016.06.022
   Saaristo AM, 2012, ANN SURG, V255, P468, DOI 10.1097/SLA.0b013e3182426757
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   Scaglioni MF, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58010067
   Scaglioni MF, 2022, MICROSURG, V42, P170, DOI 10.1002/micr.30712
   Scaglioni MF, 2021, J SURG ONCOL, V123, P96, DOI 10.1002/jso.26228
   Scaglioni MF, 2020, MICROSURG, V40, P598, DOI 10.1002/micr.30558
   Scaglioni MF, 2018, MICROSURG, V38, P232, DOI 10.1002/micr.30268
   Scaglioni MF, 2018, MICROSURG, V38, P222, DOI 10.1002/micr.30079
   Scaglioni MF, 2017, MICROSURG, V37, P947, DOI 10.1002/micr.30246
   Wagner JM, 2022, MICROSURG, V42, P239, DOI 10.1002/micr.30850
   Wolfs JAGN, 2020, BREAST CANCER RES TR, V179, P131, DOI 10.1007/s10549-019-05450-2
   Wu P, 2020, PRS-GLOB OPEN, V8, DOI 10.1097/GOX.0000000000002912
   Xia TY, 2023, ANN SURG ONCOL, V30, P1823, DOI 10.1245/s10434-022-12791-8
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   Yang JCS, 2021, J CLIN MED, V10, DOI 10.3390/jcm10143121
NR 32
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD JAN
PY 2024
VL 44
IS 1
DI 10.1002/micr.31119
EA SEP 2023
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KG5S5
UT WOS:001070623900001
PM 37743714
OA Bronze
DA 2026-07-24
ER

PT J
AU Verstegen, MHP
   Bouwense, SAW
   van Workum, F
   ten Broek, R
   Siersema, PD
   Rovers, M
   Rosman, C
AF Verstegen, Moniek H. P.
   Bouwense, Stefan A. W.
   van Workum, Frans
   ten Broek, Richard
   Siersema, Peter D.
   Rovers, Maroeska
   Rosman, Camiel
TI Management of intrathoracic and cervical anastomotic leakage after
   esophagectomy for esophageal cancer: a systematic review
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Anastomotic; Leakage; Intrathoracic; Cervical; Esophagectomy; Treatment
ID STENT; COMPLICATIONS; PLACEMENT; DIAGNOSIS; DILATION; SURGERY; TUBE
AB BackgroundAnastomotic leakage (0-30%) after esophagectomy is a severe complication and is associated with considerable morbidity and mortality. The aim of this study was to determine which treatment for anastomotic leakage after esophagectomy have the best clinical outcome, based on the currently available literature.MethodsA systematic literature search was performed in Medline, Embase, and Web of Science until April 2017. All studies reporting on the specific treatment of cervical or intrathoracic anastomotic leakage following esophagectomy with gastric tube reconstruction for esophageal or cardia cancer were included. The primary outcome parameter was postoperative mortality. Methodological quality was assessed by the Newcastle-Ottawa Quality Assessment Scale.ResultsNineteen retrospective cohort studies including 273 patients were identified. Methodological quality of all studies was poor to moderate. Mortality rates of intrathoracic anastomotic leakages in the treatment groups were as follows: conservative (14%), endoscopic stent (8%), endoscopic drainage (8%), endoscopic vacuum-assisted closure system (0%), and surgery treatment group (50%). Mortality rates of cervical anastomotic leakages in the treatment groups were as follows: conservative (8%), endoscopic stent (29%), and endoscopic dilatation (0%).DiscussionDue to small cohorts, heterogeneity between studies, and lack of data regarding leakage characteristics, no evidence supporting a specific treatment for anastomotic leakage after esophagectomy was found. A severity score based on leakage characteristics instead of treatment given is essential for determining the optimal treatment of anastomotic leakage. In the absence of robust evidence-based treatment guidelines, we suggest customized treatment depending on sequelae of the leak and clinical condition of the patient. PrDepartment of Surgery, Radboudumc, P.O.B. 9101/618 NLactical advices are provided.Trial registrationRegistration number PROSPERO: CRD42016032374.
C1 [Verstegen, Moniek H. P.; Bouwense, Stefan A. W.; van Workum, Frans; ten Broek, Richard; Rosman, Camiel] Radboudumc, Dept Surg, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
   [Siersema, Peter D.] Radboudumc, Gastroenterol & Hepatol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
   [Rovers, Maroeska] Radboudumc, Operating Rooms & Hlth Evidence, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen
RP Verstegen, MHP (通讯作者)，Radboudumc, Dept Surg, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands.
EM moniek.verstegen@radboudumc.nl
RI ; rosman, camiel/F-9059-2016; Bouwense, Stefan/P-6468-2015; Broek,
   Richard/M-9038-2016; Rovers, Maroeska/F-2969-2014; Siersema,
   Peter/V-1636-2019; van Workum, Frans/F-9311-2016
OI Verstegen, Moniek/0000-0002-8371-509X; rosman,
   camiel/0000-0002-9152-3987; Bouwense, Stefan/0000-0002-7600-9429;
   Rovers, Maroeska/0000-0002-3095-170X; 
CR Al-Issa MA, 2014, SAUDI J GASTROENTERO, V20, P39, DOI 10.4103/1319-3767.126315
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   [Anonymous], 2019, TREATMENT ANASTOMOTI
   [Anonymous], 2015, PROSPERO
   Bhasin DK, 2000, ENDOSCOPY, V32, P469, DOI 10.1055/s-2000-12967
   Biere SSAY, 2011, DIGEST SURG, V28, P29, DOI 10.1159/000322014
   Blackmon SH, 2007, ANN THORAC SURG, V83, P1805, DOI 10.1016/j.athoracsur.2007.01.046
   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
   Dikken JL, 2012, EUR J CANCER, V48, P1624, DOI 10.1016/j.ejca.2012.01.009
   Dindo D, 2004, ANN SURG, V240, P205, DOI [10.17116/hirurgia2018090162, 10.1097/01.sla.0000133083.54934.ae]
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   Jiang F, 2011, J SURG RES, V171, P448, DOI 10.1016/j.jss.2010.07.005
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   Shuto K, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12492
   Tuebergen D, 2008, J GASTROINTEST SURG, V12, P1168, DOI 10.1007/s11605-008-0500-4
   van Heijl M, 2010, ANN SURG, V251, P1064, DOI 10.1097/SLA.0b013e3181deb4b7
   van Rossum PSN, 2017, DIS ESOPHAGUS, V30, DOI 10.1111/dote.12472
   Wells G., 2014, The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, DOI DOI 10.1007/S10654-010-9491-Z
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NR 36
TC 76
Z9 89
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD APR 4
PY 2019
VL 14
AR 17
DI 10.1186/s13017-019-0235-4
PG 12
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA HS1UB
UT WOS:000463646500001
PM 30988695
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Stremitzer, S
   Bachleitner-Hofmann, T
   Gradl, B
   Gruenbeck, M
   Bachleitner-Hofmann, B
   Mittlboeck, M
   Bergmann, M
AF Stremitzer, Stefan
   Bachleitner-Hofmann, Thomas
   Gradl, Bernhard
   Gruenbeck, Matthias
   Bachleitner-Hofmann, Barbara
   Mittlboeck, Martina
   Bergmann, Michael
TI Mesh Graft Infection Following Abdominal Hernia Repair: Risk Factor
   Evaluation and Strategies of Mesh Graft Preservation. A Retrospective
   Analysis of 476 Operations
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; PRESSURE WOUND
   THERAPY; PREDICTIVE FACTORS; POLYPROPYLENE
AB Background Mesh graft infection after prosthetic hernia repair is a challenging complication usually treated by mesh removal. The aim of this study was to identify risk factors associated with mesh infection and to assess the efficacy of conservative wound therapy in preserving an infected mesh.
   Methods We performed a retrospective analysis of 476 consecutive patients with incisional hernia who received mesh graft repair between February I, 2000 and February 28, 2005 at our institution using chart review and clinical investigation.
   Results Thirty-one of 476 (6.5%) patients developed a deep surgical site infection involving the implanted mesh graft. Upon multivariate analysis, operation time was the only significant risk factor associated with mesh infection (p = 0.0038). Seventeen (55%) of 31 infected mesh grafts were preserved by conservative means. There was a significant association between the type of mesh graft used and the probability of mesh preservation in case of infection: While conservative therapy led to preservation of 100% of infected polyglactin/polypropylene meshes, only 20% of infected polypropylene and 23% of infected PTFE/polypropylene meshes could be salvaged using conservative means (p<0.0001). In none of the patients with preserved mesh graft was hernia recurrence at the former site of infection observed.
   Conclusions Operation time is the only significant risk factor associated with mesh graft infection following incisional hernia repair. Conservative treatment should be applied in case of infection of absorbable mesh grafts such as polypropylene/polyglactin, while nonabsorbable meshes such as PTFE/polypropylene or pure polypropylene are much less amenable to conservative treatment, usually requiring early surgical removal.
C1 [Stremitzer, Stefan; Bachleitner-Hofmann, Thomas; Gradl, Bernhard; Gruenbeck, Matthias; Bergmann, Michael] Med Univ Vienna, Dept Surg, A-1090 Vienna, Austria.
   [Bachleitner-Hofmann, Barbara] Med Univ Vienna, Dept Anaesthesia Gen Intens Care & Pain Managemen, A-1090 Vienna, Austria.
   [Mittlboeck, Martina] Med Univ Vienna, Core Unit Med Stat & Informat, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna
RP Bachleitner-Hofmann, T (通讯作者)，Med Univ Vienna, Dept Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM thomas.bachleitner-hofmann@meduniwien.ac.at
RI Bachleitner-Hofmann, Thomas/I-4832-2015; Bergmann, Michael/GZK-7700-2022
OI Bachleitner-Hofmann, Thomas/0000-0002-4201-8247; Bergmann,
   Michael/0000-0001-8529-1166; Mittlboeck, Martina/0000-0003-1097-4047
CR [Anonymous], POS DOC MAN WOUND IN
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NR 27
TC 93
Z9 115
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD JUL
PY 2010
VL 34
IS 7
BP 1702
EP 1709
DI 10.1007/s00268-010-0543-z
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 615AP
UT WOS:000279103400044
PM 20372901
DA 2026-07-24
ER

PT J
AU Baser, NT
   Isik, V
   Bulutoglu, R
   Gökrem, S
   Aslan, G
AF Baser, Nesrin Tan
   Isik, Volkan
   Bulutoglu, Refika
   Goekrem, Serdar
   Aslan, Guercan
TI Subatmospheric pressure wound dressing in wound management:: Medical
   education
SO TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
LA Turkish
DT Article
DE wound healing; occlusive dressings; varicose ulcer; diabetic foot;
   surgical wound dehiscence
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; TOPICAL
   NEGATIVE-PRESSURE; DIABETIC FOOT WOUNDS; SECURING SKIN-GRAFTS; DEGLOVING
   INJURIES; DONOR-SITE; TISSUE DEFECTS; ABDOMINAL-WALL; STERNAL WOUNDS
AB Subatmospheric pressure dressing (SPWD) is a new wound dressing that has been used latterly. SPWD is the controlled application of subatmospheric pressure to a wound using an electrical pump to intermittently or continuously convey subatmospheric pressure through connecting tubing to a specialized wound dressing. Recent studies with this wound dressing, the use of which was initially recomended for chronic wounds, has shown that it can effectively be used for acute wounds, skin grafted areas and donor site care, degloving injuries and bums. SPWD is a topical treatment used to promote healing in acute and chronic wounds by applying subatmospheric pressure to the wound bed. Four board mechanisms of action are proposed: increase of local blood supply, mechanical deformation, removal of harmful enzymes from the wound bed, decrease intertisiel edema. The combination of these mechanisms makes the SPWD treatment an extremely versatile tool in the armamentarium of wound healing. SPWD is generally well tolerated and, with few complications. Numerous case studies and articles have documented this treatment effectiveness. But, recent experimental studies, evaluations and personal experience raise many questions about the currently treatment protocol of SPWD: Is intermittent subatmospheric pressure therapy equivalent to continuos subatmospheric pressure wound therapy, how is optimal pressure level for wound healing?
   In this article, the past and present of subatmospheric pressure wound care is revised by considering articles within the accessible literature. Furthermore, insufficient and inquisitional aspects of this method is also emphasized.
C1 [Baser, Nesrin Tan; Isik, Volkan; Bulutoglu, Refika; Goekrem, Serdar; Aslan, Guercan] Ankara Egitim Arastirma Hastanesi, Rekonstruktif Estetek Cerrahi Klin, Ankara, Turkey.
C3 Ankara Training & Research Hospital
RP Baser, NT (通讯作者)，Ankara Egitim Arastirma Hastanesi, Rekonstruktif Estetek Cerrahi Klin, 2 Plast, Ankara, Turkey.
EM drbaser@superonline.com
RI Tan Başer, Nesrin/AAR-8330-2021
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NR 94
TC 3
Z9 3
U1 0
U2 7
PU ORTADOGU AD PRES & PUBL CO
PI ANKARA
PA TURKOCAGI CAD NO 30, BALGAT, ANKARA, 06520, TURKEY
SN 1300-0292
EI 2146-9040
J9 TURK KLIN TIP BILIM
JI Turk. Klin. Tip Bilim. Derg.
PD DEC
PY 2007
VL 27
IS 6
BP 902
EP 915
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 282QT
UT WOS:000254583000014
DA 2026-07-24
ER

PT J
AU Kim, EK
   Hong, JP
AF Kim, Eun Key
   Hong, Joon Pio
TI Efficacy of negative pressure therapy to enhance take of 1-stage
   allodermis and a split-thickness graft
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE 1-stage allodermis and split-thickness skin graft; negative pressure
   therapy
ID VACUUM-ASSISTED CLOSURE; RADIAL FOREARM FLAP; DONOR-SITE; WOUND CONTROL;
   SKIN-GRAFTS; DRESSINGS; MORBIDITY
AB Negative pressure therapy has been used in various conditions to promote wound healing. It has also been used to secure a skin graft by improving microcirculation and providing tight adhesion between the graft and the recipient bed. The authors coupled the idea of negative pressure therapy for 1-stage allodermis and a split-thickness skin graft. This prospective study presents 47 cases of skin defects treated by I-stage allodermis and a split-thickness skin graft. The patients were divided into 2 groups either treated with simultaneous aid of negative pressure therapy for 5 days (group 1, n = 37) or a classic tieover dressing (group 2, n = 10). In group 1, 97.8% graft take was noted at day 5 and the mean time until complete healing was 5.8 days. In group 2, 84% graft take was noted at day 5 and mean time until complete healing was 8.9 days with an average number of 3.2 dressings. Statistically significant graft take (day 5) and time until complete healing was noted (P < 0.05). Good aesthetic and functional result mimicking a full-thickness skin graft was achieved in both groups. However, frequent dressings, longer time to heal, and more restriction to the graft site were needed for group 2. Split-thickness skin added to allodermis provided a sufficient amount of dermis to prevent contracture, and the negative pressure therapy ensured fast and complete take of the 2-layered composite graft. This option can be used to achieve healing mimicking a full-thickness skin graft without requiring large full-thickness donor sites.
C1 Univ Ulsan, Coll Med, Dept Plast & Reconstruct Surg, Asan Med Ctr, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Univ Ulsan, Coll Med, Dept Plast & Reconstruct Surg, Asan Med Ctr, 388-1 PungNap-2Dong, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Hong, Joon/AEV-0712-2022
CR [Anonymous], BR J PLAST SURG
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NR 29
TC 59
Z9 68
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-7043
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD MAY
PY 2007
VL 58
IS 5
BP 536
EP 540
DI 10.1097/01.sap.0000245121.32831.47
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 161RK
UT WOS:000246033000013
PM 17452839
DA 2026-07-24
ER

PT J
AU Leffler, M
   Kneser, U
   Bach, AD
   Kopp, J
   Horch, RE
AF Leffler, M
   Kneser, U
   Bach, AD
   Kopp, J
   Horch, RE
TI Vacuum-assisted closure (VAC®) of disastrous wound conditions in
   Madelung disease
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum therapy; wound healing disorder; Madelung disease; Launois
   Bensaude syndrome; benign lipomatosis
ID LAUNOIS-BENSAUDE-SYNDROME; LIPOMATOSIS
AB Introduction: A 54 year old patient presented with a Madelung disease. Symmetrically fatty deposits were present on both upper arms, at the abdomen and both thighs. Dermatitis was seen in the axillary fold at the skin bearing surfaces. Shoulder movement was impaired. Liposuction of both upper arms has already been performed, but no significant improvement was obtained. Methods and results: We performed a dermolipectomy of both upper arms. Postoperatively the patient suffered from a severe wound dehiscence with fulminant wound infection and septic clinical condition. Because of the large wound surface (1/3 of the upper arm circumference) anemia occurred and had to be treated with blood transfusions. Wound exsudation caused a general hypoproteinemia. Multiple surgical debridements were necessary in order to clean the wound from necrotic tissue and afterwards moist dressings were applied. Furthermore the patient received intravenous antibiotic treatment. After stabilisation of the general condition of the patient and the wound situation a poly-vinyle sponge and a vacuum-sealing were applied and continuous suction was performed (125 mm Hg). This resulted in a significant improvement of the wound situation in regards to wound cleaning, induction of granulation tissue, wound size diminishment, reduction of oedema and pain reduction. After four weeks of vacuum therapy defect coverage was possible and split thickness skin grafting was performed. The skin graft the vacuum dressing on the fifth day the skin graft has completely healed. Discussion: Vacuum therapy is suitable for disastrous wound conditions in order to achieve a defect size reduction, pain reduction and create a clean wound with granulation tissue for further surgical defect coverage using skin grafts or flaps.
C1 Univ Klinikum Erlangen Nurnberg, Chirurg Univ Klin, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen Nurnberg, Chirurg Univ Klin, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI Horch, Raymund E/H-8128-2019
OI Horch, Raymund E/0000-0002-6561-2353
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Webb Lawrence X, 2002, J Am Acad Orthop Surg, V10, P303
NR 14
TC 3
Z9 4
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S15
EP S18
DI 10.1055/s-2006-921473
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100005
PM 16575638
DA 2026-07-24
ER

PT J
AU Haas, EJ
   Hamzeh, BF
   Aryanpour, Z
   Yu, JW
   Mathes, DW
   Kaoutzanis, C
AF Haas, Evan J.
   Hamzeh, Bilal F.
   Aryanpour, Zain
   Yu, Jason W.
   Mathes, David W.
   Kaoutzanis, Christodoulos
TI Improving the Patient Experience in Breast Reconstruction: ERAS and
   Beyond
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE breast reconstruction; mammaplasty; perioperative care; enhanced
   recovery after surgery (ERAS); patient-reported outcome measures
   (PROMs); patient-centered care; patient satisfaction; clinical protocols
ID VACUUM-ASSISTED CLOSURE; NEGATIVE-PRESSURE THERAPY; ABDOMINIS PLANE
   BLOCKS; DIEP FLAP HARVEST; PERFORATOR FLAP; ENHANCED RECOVERY; REPORTED
   OUTCOMES; COST-EFFECTIVENESS; ARTERY PERFORATOR; NERVE COAPTATION
AB Background and Objectives: Breast reconstruction after mastectomy has been shown to significantly improve psychosocial wellbeing and quality of life. Enhanced Recovery After Surgery (ERAS) protocols, especially those tailored to breast reconstruction, have revolutionized recovery by reducing complications, pain, opioid use, and hospital stay while improving patient satisfaction. The purpose of this narrative review was to present existing practices and supporting evidence within current ERAS protocols, as well as propose a modern ERAS framework centered around enhancing the patient experience following breast reconstruction. Methods: A focused literature search was conducted to identify studies investigating emerging approaches to patient care and surgical techniques adopted as part of a broader ERAS workflow Results: Some recent innovations include digital ERAS tracking, robot-assisted techniques, neurotization, and closed incision negative pressure therapy (ciNPT). These innovations show promise in reducing morbidity following reconstruction and may greatly improve sensory and functional outcomes. These advancements also reflect a shift toward more holistic, patient-centered care, extending beyond immediate clinical needs to address long-term wellbeing through psychosocial support and patient-reported outcome measures. Incorporating tools that validate patient perspectives helps guide interventions to optimize satisfaction and recovery. Conclusions: Future research should aim to standardize ERAS protocols by incorporating evidence-based practices, reinforcing breast reconstruction as a patient-centered, evidence-driven process that is focused on comprehensive recovery and improved quality of life.
C1 [Haas, Evan J.; Hamzeh, Bilal F.] Univ Colorado, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Aryanpour, Zain; Yu, Jason W.; Mathes, David W.; Kaoutzanis, Christodoulos] Univ Colorado, Dept Surg, Div Plast & Reconstruct Surg, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz;
   University of Colorado System; University of Colorado Anschutz
RP Kaoutzanis, C (通讯作者)，Univ Colorado, Dept Surg, Div Plast & Reconstruct Surg, Anschutz Med Campus, Aurora, CO 80045 USA.
EM evan.haas@cuanschutz.edu; bilal.hamzeh@cuanschutz.edu;
   zain.aryanpour@cuanschutz.edu; jason.yu@cuanschutz.edu;
   david.mathes@cuanschutz.edu; ckaoutzanis@gmail.com
RI ; Hamzeh, Bilal/AAI-2415-2020
OI Kaoutzanis, Christodoulos/0000-0002-5631-8355; Hamzeh,
   Bilal/0000-0003-0615-2972; Aryanpour, Zain/0000-0002-5328-0726; Haas,
   Evan/0000-0001-7953-7983
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NR 122
TC 3
Z9 4
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG 7
PY 2025
VL 14
IS 15
AR 5595
DI 10.3390/jcm14155595
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6EK5A
UT WOS:001551383800001
PM 40807212
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Moellhoff, N
   Heidekrueger, PI
   Frank, K
   Pistek, S
   Alt, V
   Giunta, RE
   Ehrl, D
AF Moellhoff, Nicholas
   Heidekrueger, Paul I.
   Frank, Konstantin
   Pistek, Svenja
   Alt, Verena
   Giunta, Riccardo E.
   Ehrl, Denis
TI Comparing the Time-Dependent Evolution of Microcirculation in Gracilis
   vs. ALT Flaps Using Laser-Doppler Flowmetry and Tissue-Spectrometry
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE microvascular flow; O2C; anastomosis; free flap; microsurgery
ID FREE-MUSCLE FLAPS; VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; RECONSTRUCTION;
   DENERVATION; VELOCITY; SURVIVAL; HEAD; NECK
AB Postoperative free flap monitoring is considered a key component of care after microsurgical reconstruction. To achieve successful flap salvage after surgical revision, early recognition of vascular compromise is required. The aim of this study was to assess and compare the time-dependent evolution of microcirculation in gracilis muscle (GM) and anterolateral thigh (ALT) flaps. This study included continuous measurements of blood flow (flow), hemoglobin oxygenation (SO2) and the relative amount of hemoglobin (rHb) using laser-doppler flowmetry and tissue-spectrometry (O2C, LEA Medizintechnik, Giessen, Germany) over a time-period of 72 h. Microcirculation was assessed in a total of 66 viable free flaps (GM n = 40; ALT n = 26). A statistically significant positive correlation between time post-anastomosis and microvascular flow was found for both GM and ALT flaps with r(s) = 0.384 (p < 0.001) and r(s) = 0.178 (p = 0.015), respectively. No significant positive or negative correlations between time post-anastomosis and SO2 were found for both GM and ALT flaps with r(s) = 0.052 (p = 0.387) and r(s) = -0.018 (p = 0.805), respectively. Overall, a significant negative correlation between time post-anastomosis and rHb was found for GM flaps with r(s) = -0.140 (p = 0.019). For ALT flaps, no significant positive or negative correlation was found with r(s) = -0.011 (p = 0.887). Microcirculation differs in different flap entities, and surgeons should be aware of these differences in order to correctly evaluate and classify the values of flow, SO2 and rHb obtained when using the O2C device for postoperative monitoring.
C1 [Moellhoff, Nicholas; Frank, Konstantin; Pistek, Svenja; Alt, Verena; Giunta, Riccardo E.; Ehrl, Denis] Ludwig Maximilian Univ Munich, Univ Hosp, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.
   [Heidekrueger, Paul I.] Univ Regensburg, Ctr Plast Aesthet Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
C3 University of Munich; University of Regensburg
RP Ehrl, D (通讯作者)，Ludwig Maximilian Univ Munich, Univ Hosp, Div Hand Plast & Aesthet Surg, D-81377 Munich, Germany.
EM nicholas.moellhoff@med.uni-muenchen.de; paul@heidekrueger.net;
   konstantin.frank@med.uni-muenchen.de; svenja.pistek@campus.lmu.de;
   verena.alt@med.uni-muenchen.de; riccardo.giunta@med.uni-muenchen.de;
   denis.ehrl@med.uni-muenchen.de
RI Frank, Konstantin/AAI-2004-2020; Heidekrueger, Paul/AAC-8342-2022;
   Giunta, Riccardo/JVN-5790-2024
OI Ehrl, Denis/0000-0001-9394-8412; Heidekrueger, Paul/0000-0002-4656-3808;
   Giunta, Riccardo/0009-0007-7421-1213
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NR 34
TC 13
Z9 13
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2022
VL 11
IS 9
AR 2425
DI 10.3390/jcm11092425
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1F9NY
UT WOS:000795487600001
PM 35566551
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kao, HK
   Hsu, HH
   Chuang, WY
   Chang, KP
   Chen, B
   Guo, L
AF Kao, H. -K.
   Hsu, H. -H.
   Chuang, W. -Y.
   Chang, K. -P.
   Chen, B.
   Guo, L.
TI Experimental study of fat grafting under negative pressure for wounds
   with exposed bone
SO BRITISH JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; ANGIOGENESIS;
   PROLIFERATION; MECHANISMS; DEATH; ADIPOCYTES; ACTIVATION; THERAPY;
   MATRIX
AB BackgroundThe combination of fat grafting and negative pressure (VAC) therapy represents a synergistic interaction of all essential components for wound healing. The aim of this experimental study was to determine whether it could promote healing of wounds with exposed bone.
   MethodsFull-thickness wounds with denuded bone in Sprague-Dawley rats were treated with either polyurethane foam dressing, fat grafting alone, polyurethane foam dressing with VAC, or polyurethane foam dressing with VAC combined with a single, or two administrations of fat graft. Wound healing kinetics, tissue growth, cell proliferation (Ki-67) and angiogenesis (platelet endothelial cell adhesion molecule 1 and -smooth muscle actin) were investigated. Messenger RNA levels related to angiogenesis (vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF)), profibrosis (platelet-derived growth factor A and transforming growth factor ), adipocyte expression (fatty acid-binding protein (FABP) 4 and peroxisome proliferator activated receptor ), and extracellular matrix remodelling (collagen I) were measured in wound tissues.
   ResultsWounds treated by VAC combined with fat grafting were characterized by cell proliferation, neoangiogenesis and maturation of functional blood vessels; they showed accelerated granulation tissue growth over the denuded bone compared with VAC- or foam dressing-treated wounds. Fat grafting alone over denuded bone resulted in complete necrosis. Expression of angiogenesis markers (VEGF and b-FGF) and adipocyte expression factors (FABP-4) was upregulated in wounds treated with VAC combined with fat grafting.
   ConclusionFat grafting with VAC therapy may represent a simple but effective clinical solution for a number of complex tissue defects, and warrants testing in clinical models.
C1 [Kao, H. -K.] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan.
   [Hsu, H. -H.] Chang Gung Mem Hosp, Kidney Res Ctr, Dept Nephrol, Taoyuan, Taiwan.
   [Chuang, W. -Y.] Chang Gung Mem Hosp, Dept Pathol, Taoyuan, Taiwan.
   [Chang, K. -P.] Chang Gung Mem Hosp, Dept Otolaryngol & Head Neck Surg, Taoyuan, Taiwan.
   [Chang, K. -P.] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Chen, B.; Guo, L.] Lahey Hosp & Med Ctr, Dept Plast Surg, Burlington, MA 01805 USA.
   [Chen, B.] Kunming Med Univ, Burn Inst Yunnan Prov, Dept Reparat & Reconstruct Surg, Affiliated Hosp 2, Kunming, Peoples R China.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung University;
   Lahey Hospital & Medical Center; Kunming Medical University
RP Guo, L (通讯作者)，Lahey Hosp & Med Ctr, Dept Plast Surg, 41 Mall Rd,6W, Burlington, MA 01805 USA.
EM lifei.guo@lahey.org
RI /AAG-3449-2019; Chuang, Wen-Yu/I-8013-2019
OI Chen, Bin/0000-0002-7606-1382; Chuang, Wen-Yu/0000-0002-3729-073X; Guo,
   Lifei/0000-0003-2019-0086
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NR 23
TC 20
Z9 25
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD JUL
PY 2015
VL 102
IS 8
BP 998
EP 1005
DI 10.1002/bjs.9826
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CK8VD
UT WOS:000356516400018
PM 25974177
OA Bronze
DA 2026-07-24
ER

PT J
AU Krishnakumar, A
   Roth, A
   Srinivasan, P
   Rana, MM
   Gallina, NLF
   Sarnaik, D
   Mccain, RR
   Cox, AD
   Seleem, MN
   Bhunia, AK
   Rahimi, R
AF Krishnakumar, Akshay
   Roth, Alexander
   Srinivasan, Praveen
   Rana, Muhammad Masud
   Gallina, Nicholas L. F.
   Sarnaik, Devendra
   Mccain, Robyn R.
   Cox, Abigail D.
   Seleem, Mohamed N.
   Bhunia, Arun K.
   Rahimi, Rahim
TI Smart Wearable Ozone Therapy System for Managing Multidrug-Resistant
   Wound Infections
SO ADVANCED THERAPEUTICS
LA English
DT Article
DE antibiotic adjunct therapy; chronic wounds; ozone therapy; smart wound
   therapy
ID SILVER-RELEASING DRESSINGS; VACUUM-ASSISTED CLOSURE; BACTERIAL BURDEN;
   PERMEABILITY; MANAGEMENT; BIOBURDEN
AB Multidrug-resistant (MDR) bacterial infections represent a critical challenge in wound care, leading to treatment failure, prolonged healing, and increased morbidity and mortality worldwide. Among MDR pathogens, Pseudomonas aeruginosa is particularly problematic due to its adaptive resistance mechanisms, underscoring the urgent need for alternative, non-antibiotic therapeutic strategies. Ozone has demonstrated potent antimicrobial efficacy while promoting wound healing and exhibiting a low propensity for resistance development; however, conventional ozone delivery systems are bulky, poorly suited for ambulatory use, and pose risks of environmental leakage and unintended exposure. To address these limitations, we have developed a smart wearable ozone therapy system capable of precise, localized ozone delivery directly to the wound bed. The platform integrates on-demand ozone generation, real-time sensing, and controlled air circulation within a compact, reusable unit, coupled to a disposable wound interface patch via double-lumen tubing. Embedded sensors continuously regulate ozone concentrations within therapeutic windows while detecting leakage and triggering automatic shutdown to ensure patient and environmental safety. System characterization demonstrated that localized low-level ozone exposure (75 ppm), when combined with Vancomycin (400 & micro;g & centerdot;mL- 1), eradicated planktonic bacterial cultures to undetectable levels within 4 h while maintaining minimal cytotoxicity toward mammalian cells. For the first time, this fully integrated wearable platform was validated in a Pseudomonas aeruginosa-infected porcine wound model, achieving approximately 90% bacterial reduction after four consecutive daily 6 h treatments and accelerating wound closure by nearly threefold compared with silver dressings or topical antibiotic treatment alone. These results establish a safe, effective, and translationally viable wearable ozone therapy system for the management of MDR-infected wounds.
C1 [Krishnakumar, Akshay; Srinivasan, Praveen; Rana, Muhammad Masud; Rahimi, Rahim] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA.
   [Roth, Alexander] Purdue Univ, Sch Mech Engn, W Lafayette, IN USA.
   [Gallina, Nicholas L. F.; Bhunia, Arun K.] Purdue Univ, Dept Food Sci, Mol Food Microbiol Lab, W Lafayette, IN USA.
   [Gallina, Nicholas L. F.; Bhunia, Arun K.] Purdue Univ, Purdue Inst Inflammat Immunol & Infect Dis, W Lafayette, IN USA.
   [Sarnaik, Devendra; Rahimi, Rahim] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
   [Mccain, Robyn R.] Purdue Univ, Ctr Comparat Translat Res, W Lafayette, IN USA.
   [Cox, Abigail D.; Bhunia, Arun K.] Purdue Univ, Coll Vet Med, Dept Comparat Pathobiol, W Lafayette, IN USA.
   [Seleem, Mohamed N.] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA USA.
C3 Purdue University System; Purdue University; Purdue University System;
   Purdue University; Purdue University in Indianapolis; Purdue University
   System; Purdue University; Purdue University System; Purdue University;
   Purdue University System; Purdue University; Purdue University System;
   Purdue University; Purdue University System; Purdue University; Virginia
   Polytechnic Institute & State University
RP Rahimi, R (通讯作者)，Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA.; Rahimi, R (通讯作者)，Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
EM rrahimi@purdue.edu
RI Seleem, Mohamed/H-2774-2018; Krishnakumar, Akshay/AFK-0008-2022; Bhunia,
   Arun/K-7639-2012; Rana, Masud/AAQ-4529-2020
OI Rahimi, Rahim/0000-0001-5302-782X
FU Wabash Heartland Innovation Network (WHIN); National Institute of
   Diabetes and Digestive and Kidney Diseases [IR21DK128715-01A1]; National
   Institute of Food and Agriculture [13699514]
FX The authors would like to acknowledge the funding support from Wabash
   Heartland Innovation Network (WHIN), Scalable Manufacturing Aware and
   Responsive Thin Films (SMART), National Institute of Diabetes and
   Digestive and Kidney Diseases program at the National Institutes of
   Health (IR21DK128715-01A1), and Ralph W. and Grace M. Showalter Research
   Trust. The authors would also like to acknowledge the support staff and
   engineers of Bindley Bioscience Center, Birck Nanotechnology Center, and
   School of Electrical and Computer Engineering at Purdue University.
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
EI 2366-3987
J9 ADV THER-GERMANY
JI Adv. Therap.
PD MAR 10
PY 2026
VL 9
IS 3
AR e00541
DI 10.1002/adtp.202500541
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EV9GA
UT WOS:001711010000001
OA hybrid
DA 2026-07-24
ER

PT J
AU Mucha, AW
   Strandby, RB
   Nerup, NA
   Achiam, MP
AF Mucha, Andreas Weise
   Strandby, Rune Broni
   Nerup, Nikolaj Albeck
   Achiam, Michael Patrick
TI Treatment of intrathoracic anastomotic leakage following esophagectomy
   for gastroesophageal cancer: a systematic review
SO DISEASES OF THE ESOPHAGUS
LA English
DT Article
DE anastomotic leak; drainage; esophagectomy; gastrointestinal endoscopy;
   stent; systematic review
ID VACUUM-ASSISTED CLOSURE; TUBE DRAINAGE; METAL STENTS; MANAGEMENT;
   RESECTION; COMPLICATIONS; PREDICTORS; PLACEMENT; THERAPY
AB Anastomotic leakage (AL) is a significant complication following esophagectomy. AL affects 8%-17% of patients and is associated with increased morbidity, mortality, and hospital stay. To this date, no consensus exists on the most optimal treatment. This systematic review aimed to determine the most effective treatment approach. A systematic search of Medline, Web of Science, Cochrane, Scopus, and Embase databases was conducted. Only studies reporting on the treatment of intrathoracic anastomotic leakage after esophagectomy with gastric conduit reconstruction for cancer were included. Studies investigating other esophageal disorders or failing to report the location of the anastomosis were excluded. The methodological quality and risk of bias were assessed using the Newcastle-Ottawa Scale for cohort studies. Out of 12,966 identified studies, 38 were included for analysis after removing duplicates and screening titles, abstracts, and full texts. Of these, five were found to be of poor methodological quality and 33 were of moderate quality. The most researched treatment methods were Endoluminal vacuum therapy (EVT), naso-fistula tube drainage (NFTD), and stent treatment. The success and mortality rates for EVT were 82% and 10.7%, for NFTD, 94% and 5.2%, and, for stent treatment, 75.1% and 13.5%, respectively. AL can be effectively treated with EVT, stent treatment, and NFTD. The NFTD approach appeared to have a higher success rate and lower mortality than other treatment modalities. However, it requires a longer treatment duration. Due to limitations within the included studies, a definitive recommendation regarding the optimal treatment for AL cannot be made.
C1 [Mucha, Andreas Weise; Strandby, Rune Broni; Nerup, Nikolaj Albeck; Achiam, Michael Patrick] Copenhagen Univ Hosp, Dept Surg & Transplantat, Rigshosp, Inge Lehmanns Vej 7, DK-2100 Copenhagen, Denmark.
   [Achiam, Michael Patrick] Univ Copenhagen, Dept Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Mucha, AW (通讯作者)，Copenhagen Univ Hosp, Dept Surg & Transplantat, Rigshosp, Inge Lehmanns Vej 7, DK-2100 Copenhagen, Denmark.
EM andreas.weise.mucha.01@regionh.dk; rune.broni.strandby.01@regionh.dk;
   nikolaj.albeck.nerup@regionh.dk; Michael.Patrick.Achiam.01@regionh.dk
RI Achiam, Michael/ABA-1694-2020; Mucha, Andreas Weise/GZL-0021-2022
OI Mucha, Andreas Weise/0000-0002-9617-9521
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NR 62
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1120-8694
EI 1442-2050
J9 DIS ESOPHAGUS
JI Dis. Esophagus
PD MAR 6
PY 2025
VL 38
IS 2
AR doaf016
DI 10.1093/dote/doaf016
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA Z3P0U
UT WOS:001438058800001
PM 40048658
DA 2026-07-24
ER

PT J
AU Cao, L
   Zeng, R
   Sun, K
   Fan, HT
AF Cao, Le
   Zeng, Ran
   Sun, Kai
   Fan, Haitao
TI Ultrasound-guided percutaneous micro-drainage tube irrigation combined
   with high negative pressure tube drainage versus debridement with closed
   suction irrigation for treating deep surgical site infection after
   spinal surgery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE incision and debridement therapy; microtube drainage; spinal surgical
   site infection
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE INFECTIONS; WOUND-INFECTION;
   THERAPY; FUSION; MANAGEMENT; EFFICACY
AB It is difficult to avoid deep surgical site infection after spinal surgery. Debridement combined with closed suction irrigation (CSI) and other treatment methods lead to greater trauma and lower satisfaction. We developed a new method for the treatment of SSI, which has the advantages of less invasiveness and lower cost. The cohort of this retrospective study comprised 26 patients with SSI after undergoing spinal surgery in our hospital from August 2017 to March 2022. The patients were divided into CSI and microtube drainage group according to treatment methods. The durations of antibiotic use and hospital stay, hospitalization costs, and functional scores during follow-up were compared between the two groups. The only baseline characteristic that differed between the two groups was sex. Infection was controlled in both groups and there were no recurrences during follow-up. However, the length of hospital stay after the first operation and the total length of stay were significantly greater in the CSI group. Hospitalization costs and antibiotic costs were significantly higher in the CSI group. Additionally, the duration of intravenous antibiotic use was significantly longer in the CSI group. Both the CSI and microtube drainage groups had significantly improved of Short Form Health Survey (SF-36) scores 6 months postoperatively. However, 3 months postoperatively, SF-36 scores were significantly lower in the CSI group. Compared with debridement followed by CSI, percutaneous micro-drainage tube irrigation combined with high negative pressure tube drainage is a more efficient and economical means of treating SSI after spinal surgery.
C1 [Cao, Le; Sun, Kai; Fan, Haitao] Anhui Med Univ, Fuyang Hosp, Dept Orthopaed, Fuyang, Peoples R China.
   [Zeng, Ran] Anhui Med Univ, Fuyang Hosp, Dept Intens Care Unit, Fuyang, Peoples R China.
   [Fan, Haitao] Ningbo Univ, Affliated Hosp 1, Dept Orthopaed, Ningbo 315000, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Ningbo University
RP Fan, HT (通讯作者)，Ningbo Univ, Affliated Hosp 1, Dept Orthopaed, Ningbo 315000, Peoples R China.
EM fht1881@163.com
RI /AAP-7287-2021
OI Cao, Le/0000-0002-7466-1237
FU Natural Science Foundation of Anhui Provincial Colleges and Universities
   [KJ2021ZD0034]
FX Natural Science Foundation of Anhui Provincial Colleges and
   Universities, Grant/Award Number: KJ2021ZD0034
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NR 24
TC 2
Z9 2
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2024
VL 21
IS 2
DI 10.1111/iwj.14435
EA OCT 2023
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JB6R1
UT WOS:001095729900001
PM 37878524
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Frykberg, RG
   Banks, J
AF Frykberg, Robert G.
   Banks, Jaminelli
TI Challenges in the Treatment of Chronic Wounds
SO ADVANCES IN WOUND CARE
LA English
DT Review
ID DIABETIC FOOT ULCERS; MESENCHYMAL STEM-CELLS; HYPERBARIC-OXYGEN THERAPY;
   EPIDERMAL-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS;
   CONVENTIONAL COMPRESSION DRESSINGS; CRYOPRESERVED AMNIOTIC MEMBRANE;
   RANDOMIZED CONTROLLED-TRIAL; EVIDENCE-BASED MANAGEMENT
AB Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.
   Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.
   Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.
   Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.
C1 [Frykberg, Robert G.; Banks, Jaminelli] Phoenix VA Hlth Care Syst, Phoenix, AZ 85012 USA.
RP Frykberg, RG (通讯作者)，Phoenix VA Hlth Care Syst, 650 East Indian Sch Rd, Phoenix, AZ 85012 USA.
EM robert.frykberg@va.gov
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NR 300
TC 1988
Z9 2405
U1 34
U2 619
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD SEP 1
PY 2015
VL 4
IS 9
BP 560
EP 582
DI 10.1089/wound.2015.0635
PG 23
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CO9GC
UT WOS:000359481100005
PM 26339534
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Cioffi, KM
   Schmiedt, CW
   Cornell, KK
   Radlinsky, MG
AF Cioffi, Krista M.
   Schmiedt, Chad W.
   Cornell, Karen K.
   Radlinsky, MaryAnn G.
TI Retrospective evaluation of vacuum-assisted peritoneal drainage for the
   treatment of septic peritonitis in dogs and cats: 8 cases (2003-2010)
SO JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
LA English
DT Article
DE cat; dog; sepsis; septic abdomen; vacuum-assisted closure; VAPD
ID GENERALIZED PERITONITIS; ABDOMINAL DRAINAGE; WOUND CONTROL; CLOSURE;
   EXPERIENCE
AB Objective - To describe the use of vacuum-assisted peritoneal drainage (VAPD) in dogs and cats with septic peritonitis.
   Design - Retrospective descriptive study.
   Setting - University Veterinary Teaching Hospital.
   Animals - Six dogs and 2 cats with septic peritonitis.
   Interventions - Application of VAPD after abdominal exploration.
   Measurements - Pre- and post-operative physical and clinicopathologic data, surgical findings, treatment, VAPD fluid production, outcome, and survival are reported.
   Main results - Eight nonconsecutive cases of septic peritonitis, consisting of 6 dogs and 2 cats, were treated surgically and had VAPD applied post-operatively. The mean duration of clinical signs prior to surgical intervention was 4 +/- 3 days. VAPD therapy was applied for a mean of 2 +/- 1.1 days and collected a median of 27 mL/kg/d of abdominal effusate. The median time in hospital was 5 days and abdominal closure was completed in 5 of the 8 patients. All specimens collected at surgery cultured positive for bacteria, most commonly Enterococcus spp. The peritoneum of 4 animals was cultured at the time of abdominal closure; 1 was negative and 3 were positive for Escherichia coli, Enterococcus spp. or gram-positive cocci. Cultures before and after surgery differed in 2 patients. Hypoproteinemia was present in all patients postoperatively. Three patients were considered survivors, all of which were dogs. Five patients died or were euthanized due to cardiopulmonary arrest (n = 3), pyothorax (n = 1), and acute, severe, septic peritonitis (n = 1).
   Conclusions - VAPD is available for maintaining abdominal drainage for the treatment of septic peritonitis after surgical intervention; however, similar to open abdominal drainage and closed suction drainage, nosocomial infection and hypoproteinemia remain challenges in the treatment of septic peritonitis.
C1 [Cioffi, Krista M.; Schmiedt, Chad W.; Cornell, Karen K.; Radlinsky, MaryAnn G.] Univ Georgia, Dept Small Anim Surg, Vet Teaching Hosp, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP Radlinsky, MG (通讯作者)，Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA 30605 USA.
EM radlinsk@uga.edu
RI ; Schmiedt, Chad/AEV-2703-2022
OI Cornell, Karen/0000-0002-3586-0559; Schmiedt, Chad/0000-0003-1561-0736
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NR 26
TC 25
Z9 28
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1479-3261
EI 1476-4431
J9 J VET EMERG CRIT CAR
JI J. Vet. Emerg. Crit. Care
PD OCT
PY 2012
VL 22
IS 5
BP 601
EP 609
DI 10.1111/j.1476-4431.2012.00791.x
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 030CK
UT WOS:000310545300013
PM 22931241
DA 2026-07-24
ER

PT J
AU Cabodi, M
   Cross, VL
   Qu, Z
   Havenstrite, KL
   SchwartZ, S
   Stroock, AD
AF Cabodi, Mario
   Cross, Valerie L.
   Qu, Zheng
   Havenstrite, Karen L.
   SchwartZ, Suzanne
   Stroock, Abraham D.
TI An active wound dressing for controlled convective mass transfer with
   the wound bed
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE wound dressings; wound healing; drug delivery; poly(hydroxyethyl
   methacrylate); poly (dimethylsiloxane)
ID VACUUM-ASSISTED CLOSURE; GRANULATION-TISSUE FORMATION;
   NEGATIVE-PRESSURE; ARTIFICIAL SKIN; PERMEABILITY; COMPRESSION;
   CARTILAGE; PHASE
AB Conventional wound dressings-gauze, plastic films, foams, and gels-do not allow for spatial and temporal control of the soluble chemistry within the wound bed, and are thus limited to a passive role in wound healing. Here, we present an active wound dressing (AWD) designed to control convective mass transfer with the wound bed; this mass transfer provides a means to tailor and monitor the chemical state of a wound and, potentially, to aid the healing process. We form this AWD as a bilayer of porous poly(hydroxyethyl methacrylate) (pHEMA) and silicone; the pHEMA acts as the interface with the wound bed, and a layer of silicone provides a vapor barrier and a support for connecting to external reservoirs and pumps. We measure the convective permeability of the pHEMA sponge, and use this value to design a device with a spatially uniform now profile. We quantify the global coefficient of mass transfer of the AWD on a dissolvable synthetic surface, and compare it to existing theories of mass transfer in porous media. We also operate the AWD on model wound beds made of calcium alginate gel to demonstrate extraction and delivery of low molecular weight solutes and a model protein. Using this system, we demonstrate both uniform mass transfer over the entire wound bed and patterned mass transfer in three spatially distinct regions. Finally, we discuss opportunities and challenges for the clinical application of this design of an AWD. (c) 2006 Wiley Periodicals. Inc.
C1 Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14853 USA.
   Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA.
   Cornell Univ, Weill Med Coll, Dept Surg, New York, NY 10021 USA.
C3 Cornell University; Cornell University; Cornell University; Weill
   Cornell Medicine
RP Stroock, AD (通讯作者)，Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14853 USA.
EM ads10@cornell.edu
RI Stroock, Abraham/HTM-5976-2023
OI Stroock, Abraham/0000-0002-8145-9977
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NR 38
TC 20
Z9 24
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD JUL
PY 2007
VL 82B
IS 1
BP 210
EP 222
DI 10.1002/jbm.b.30723
PG 13
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 184AD
UT WOS:000247612600027
PM 17106898
DA 2026-07-24
ER

PT J
AU Sawada, G
   Kim, HM
   Ichikawa, Y
   Hayashi, R
   Takata, A
   Murakami, M
   Fukunaga, H
   Morita, S
AF Sawada, Genta
   Kim, Ho Min
   Ichikawa, Yoshitoshi
   Hayashi, Rie
   Takata, Akihiro
   Murakami, Masahiro
   Fukunaga, Hiroki
   Morita, Shunji
TI Clinical Impact of Two-Week Placement of a Subcutaneous Suction Drain in
   Preventing Incisional Surgical Site Infection in Open Gastrointestinal
   Surgery with Class 4 Dirty Wound: A Retrospective Study
SO SURGICAL INFECTIONS
LA English
DT Article
DE class 4 surgery; prevention; subcutaneous suction drain; surgical site
   infection
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; ABDOMINAL
   OPERATIONS; RISK-FACTORS; REDUCE
AB Background: Two recent randomized controlled trials demonstrated the beneficial effects of subcutaneous drainage in preventing incisional surgical site infection (SSI) in colorectal surgery. This study aimed to evaluate the efficacy of subcutaneous suction drains (SSDs) compared with primary skin closure (PC) in class 4 dirty wound surgery.Patients and Methods: Eighty-one patients undergoing open gastrointestinal surgery with class 4 dirty wounds were enrolled in this study, 30 of whom underwent SSD insertion, whereas the other 51 were treated with PC. Because several studies have reported that the median onset of the development of incisional SSI was eight to 13 days after surgery, we used a two-week placement of an SSD. Comparison of patients treated with SSD and PC and multivariable analysis were performed to test the ability of SSD in decreasing the SSI rate.Results: No differences were observed between the two groups in terms of gender, body mass index, American Society of Anesthesiology score, steroid use, presence of diabetes mellitus, peri-operative transfusion, and surgery type. Surgical site infection incidence was lower in the SSD group (6.6%; 2/30) than that in the PC group (23.5%; 12/51; p = 0.069). Multivariable analysis revealed that the presence of diabetes mellitus was an important independent risk factor for incisional SSI, and the placement of an SSD has substantial preventive effects on incisional SSI (p = 0.018 and p = 0.014, respectively).Conclusions: This study suggested the potential importance of a two-week placement of an SSD for preventing incisional SSI in class 4 dirty wound surgery.
C1 [Sawada, Genta; Kim, Ho Min; Ichikawa, Yoshitoshi; Takata, Akihiro; Murakami, Masahiro; Fukunaga, Hiroki; Morita, Shunji] Itami City Hosp, Dept Surg, Itami, Japan.
   [Hayashi, Rie] Osaka Univ, Grad Sch Med, Dept Gastroenterol Surg, Osaka, Japan.
   [Sawada, Genta] Itami City Hosp, Dept Surg, Koyaike 1-100, Itami 6648540, Japan.
C3 University of Osaka
RP Sawada, G (通讯作者)，Itami City Hosp, Dept Surg, Koyaike 1-100, Itami 6648540, Japan.
EM gsawada1369@gmail.com
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NR 26
TC 1
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT 1
PY 2022
VL 23
IS 8
BP 722
EP 728
DI 10.1089/sur.2022.175
EA SEP 2022
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA 5C0UL
UT WOS:000850798600001
PM 36070600
DA 2026-07-24
ER

PT J
AU Jimenez-Rodriguez, RM
   Araujo-Miguez, A
   Sobrino-Rodriguez, S
   Heller, F
   Díaz-Pavon, JM
   Bozada Garcia, JM
   De la Portilla, F
AF Maria Jimenez-Rodriguez, Rosa
   Araujo-Miguez, Angela
   Sobrino-Rodriguez, Salvador
   Heller, Frederick
   Diaz-Pavon, Jose M.
   Bozada Garcia, Juan M.
   De la Portilla, Fernando
TI A New Perspective on Vacuum-Assisted Closure for the Treatment of
   Anastomotic Leak Following Low Anterior Resection for Rectal Cancer, Is
   It Worthy?
SO SURGICAL INNOVATION
LA English
DT Article; Proceedings Paper
CT 16th Meeting of FAECP
CY MAY 14-16, 2014
CL SPAIN
SP FAECP
DE dehiscence; colorectal cancer; anterior resection; vacuum-assisted
   therapy
ID RISK-FACTORS; SURGERY; THERAPY; ETVARD
AB Background. Anastomotic dehiscence is a common complication of anterior resection. In this work, we evaluate the management of the pelvic cavity after low rectal resection using vacuum closure (VAC) with a gastroscope, and we establish factors that determine the success of closure and analyzed the rate of ileostomy closure after leakage was resolved. Patients and Methods. This is a descriptive case series analysis conducted at a tertiary hospital. Twenty-two patients with low colorectal anastomosis leakage or opening of the rectal stump after anterior resection for rectal cancer were included. They were treated with VAC therapy. Results. The total number of endoscopic sessions was 3.1 +/- 1.9 in the anterior resection with anastomosis group and 3.2 +/- 1.8 in the Hartmann group. In 11 patients the therapy was administered in an ambulatory setting. The mean time to healing was 22.3 +/- 14.7 days. Full resolution was achieved in 19 patients (followed-up 1 year). Ileostomy closure was carried out in 5 patients (38.46%) during follow-up. None of these patients showed leakage signs. Statistically significant differences were obtained depending on the onset of therapy, with better results in patients who underwent earlier vacuum-assisted therapy (before the sixth week after initial surgery), P = .041. Conclusions. VAC therapy is an alternative to surgery that can be safely administered in an ambulatory setting. Early administration in the 6 weeks following surgery is an independent predictive factor for successful closure; however, colonic transit was only recovered in a small percentage of patients.
C1 [Maria Jimenez-Rodriguez, Rosa; Araujo-Miguez, Angela; Sobrino-Rodriguez, Salvador; Diaz-Pavon, Jose M.; Bozada Garcia, Juan M.; De la Portilla, Fernando] Virgen del Rocio Univ Hosp, Seville, Spain.
   [Maria Jimenez-Rodriguez, Rosa; Diaz-Pavon, Jose M.; De la Portilla, Fernando] Univ Seville, CSIC, IBiS, Seville, Spain.
   [Heller, Frederick] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [De la Portilla, Fernando] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Memorial Sloan Kettering
   Cancer Center; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Instituto de Salud Carlos III
RP Jimenez-Rodriguez, RM (通讯作者)，Hosp Univ Virgen del Rocio, Dept Cirugia Gen & Digest, Unidad Coloproctol, Avda Manuel Siurot S-N, Seville 41013, Spain.
EM ros_j_r@hotmail.com
RI de la Portilla, Fernando/ABD-5393-2020; /P-3148-2019
OI de la Portilla, Fernando/0000-0003-0603-2911; 
FU Instituto de Salud Carlos III, Madrid, Spain
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: CIBEREHD
   was funded by the Instituto de Salud Carlos III, Madrid, Spain.
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NR 21
TC 17
Z9 22
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD AUG
PY 2018
VL 25
IS 4
BP 350
EP 356
DI 10.1177/1553350618771410
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA GO0KR
UT WOS:000439617900006
PM 29701133
DA 2026-07-24
ER

PT J
AU Kawajiri, H
   Aeba, R
   Takaki, H
   Yozu, R
   Iwata, S
AF Kawajiri, Hiroyuki
   Aeba, Ryo
   Takaki, Hidenobu
   Yozu, Ryohei
   Iwata, Satoshi
TI Negative pressure therapy for post-sternotomy wound infections in young
   children
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Wound infection; Sternotomy; Congenital heart disease
ID VACUUM-ASSISTED CLOSURE; PEDIATRIC CARDIAC-SURGERY; MUSCLE FLAP;
   POSTOPERATIVE MEDIASTINITIS; RISK-FACTORS; EXPERIENCE
AB OBJECTIVES: Post-sternotomy wound infection remains a significant morbidity in congenital and paediatric cardiac surgery. However, the techniques used for this complication in children are not optimal in terms of mortality, morbidity and the use of medical resources. Negative pressure therapy is an effective modality in the treatment in adults, but reports of its use in children are limited. This study evaluated the use of negative pressure therapy in young children for post-sternotomy wound infections.
   METHODS: From October 2004 to June 2012, 15 consecutive cases of post-sternotomy wound infections in patients a parts per thousand currency sign6 years of age were managed with negative pressure therapy, and these patients were followed up for a parts per thousand yen12 months after wound closure. The median Aristotle comprehensive complexity score was 9.9 +/- 4.0. The infection was identified at a median of 16 days after surgery, and the procedure was performed within 24 h of diagnosis. No additional surgical procedures were applied.
   RESULTS: No cases of hospital mortality or second surgery for infection control occurred. The median duration until wound closure was 25 days (range: 5-92 days). Further, no patient showed sternal instability at treatment termination. During the mean follow-up period of 45.8 +/- 31.3 months after wound closure, no admission occurred for infection recurrence. According to a multivariable analysis, the infection depth and patient weight significantly lengthened treatment duration (P = 0.008 and 0.046, respectively).
   CONCLUSIONS: Negative pressure therapy is an effective treatment modality for wound infections in paediatric cardiac surgery and results in low morbidity, mortality and medical resource use.
C1 [Kawajiri, Hiroyuki; Aeba, Ryo; Takaki, Hidenobu; Yozu, Ryohei] Keio Univ, Div Cardiovasc Surg, Tokyo 1608582, Japan.
   [Iwata, Satoshi] Keio Univ, Ctr Infect Dis & Infect Control, Tokyo 1608582, Japan.
C3 Keio University; Keio University
RP Aeba, R (通讯作者)，Keio Univ, Div Cardiovasc Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM aebajp@gmail.com
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NR 23
TC 6
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUL
PY 2014
VL 19
IS 1
BP 102
EP 106
DI 10.1093/icvts/ivu050
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AM2HB
UT WOS:000339669900026
PM 24648466
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Shada, AL
   Rosenberger, LH
   Mentrikoski, MJ
   Silva, MA
   Feldman, SH
   Kleiner, DE
AF Shada, Amber L.
   Rosenberger, Laura H.
   Mentrikoski, Mark J.
   Silva, Michael A.
   Feldman, Sanford H.
   Kleiner, Daniel E.
TI Endoluminal Negative-Pressure Therapy for Preventing Rectal Anastomotic
   Leaks: A Pilot Study in a Pig Model
SO SURGICAL INFECTIONS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COLORECTAL SURGERY; ANTERIOR RESECTION; STOMA
AB Background: Anastomotic leak after rectal resection carries substantial morbidity and mortality. A diverting ileostomy is beneficial for high-risk anastomoses, but its creation and reversal carry a surgical risk in addition to that of resection itself. We sought an alternative method for managing complications of rectal anastomosis.
   Methods: We developed an endoluminal negative-pressure technology with a diverting proximal sump, and hypothesized that it would close anastomotic disruptions in pigs. We performed rectal resections on pigs, with primary anastomoses and the creation of an anastomotic defect. In animals in the treatment group we inserted an endoluminal negative-pressure device and kept it at a low level of continuous suction for 5 d. No device was inserted in a control group of animals. After the 5-d period of treatment we evaluated the anastomoses in both the treatment and control groups of animals for leakage, using contrast enemas. Specimens of anastomosed rectum were evaluated histologically for mucosal integrity and for the location and density of inflammatory responses.
   Results: Fourteen pigs were assigned to either the treatment (n = 10) or control (n = 4) group. Of the pigs in the treatment group, 90% had complete closure of their rectal defect, as compared with 25% of the animals in the control group (chi(2) test, p = 0.04). The animals in the treatment group had only minimal mucosal and serosal inflammation, whereas those in the control group had extensive mucosal damage with associated serositis.
   Conclusions: Endoluminal negative-pressure therapy was well-tolerated and led to successful closure of 90% of the anastomic rectal defects in the treatment group of animals in the present study. Additional evaluation of this therapy is warranted.
C1 [Shada, Amber L.; Rosenberger, Laura H.] Univ Virginia Hlth Syst, Dept Surg, Charlottesville, VA USA.
   [Mentrikoski, Mark J.] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA.
   [Silva, Michael A.] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA USA.
   [Feldman, Sanford H.] Univ Virginia, Ctr Comparat Med, Charlottesville, VA 22908 USA.
   [Kleiner, Daniel E.] Washington Univ, Dept Surg, St Louis, MO USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; Washington University (WUSTL)
RP Shada, AL (通讯作者)，Univ Virginia, Dept Surg, POB 800300, Charlottesville, VA 22908 USA.
EM as4em@virginia.edu
RI ; Feldman, Sanford/AAH-7070-2021
OI Rosenberger, Laura/0000-0002-6829-6747; Feldman,
   Sanford/0000-0001-8041-8690
FU National Institutes of Health (NIH) [5-T32-AI-078875-02]; Hunter
   Surgical Corporation
FX Dr. Rosenberger is supported by National Institutes of Health (NIH)
   Grant 5-T32-AI-078875-02 from the National Institutes of Health. The
   remaining authors declare no grant funding. Additional support for this
   study was provided by a grant from Hunter Surgical Corporation. We thank
   Gina Wimer, Jeremy Gatesman, and the rest of the University of Virginia
   Center for Comparative Medicine staff for their help executing this
   project.
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NR 23
TC 11
Z9 13
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD APR
PY 2014
VL 15
IS 2
BP 123
EP 130
DI 10.1089/sur.2012.198
PG 8
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AI9TS
UT WOS:000337282100009
PM 24476015
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ghods, M
   Grabs, R
   Kersten, C
   Chatzopoulos, PP
   Geomelas, M
AF Ghods, Mojtaba
   Grabs, Robert
   Kersten, Christiane
   Chatzopoulos, Peter P.
   Geomelas, Menedimos
TI A Modified Free Muscle Transfer Technique to Effectively Treat Chronic
   and Persistent Calcaneal Osteomyelitis
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE calcaneal osteomyelitis; reconstructive microsurgery; free gracilis
   muscle flap
ID EFFECTIVE CHOICE; WOUND THERAPY; ISLAND FLAP; FOOT; COVERAGE; HEEL; LEG
AB Objective: Successful management of chronic calcaneal osteomyelitis presents a major challenge for the plastic and reconstructive surgeon, especially in cases involving soft-tissue defects. This article describes a modified free muscle transfer technique to effectively eradicate chronic and persistent calcaneal osteomyelitis.
   Methods: Between February 2009 and September 2009, 3 male patients with persistent calcaneal osteomyelitis were treated in our clinic. All 3 had purulent drainage for a minimum of 6 months and a maximum of 23 years. Multiple surgical debridements and vacuum-assisted closure had been used in the past, but the infection remained. We used a therapeutic protocol of repeated and radical surgical debridement with removal of nearly all cancellous bone and preservation of the cortical shell of the calcaneus. After the final debridement, the bone cavity was plugged by a free gracilis muscle flap from the contralateral side. A meshed split thickness skin graft was applied. Culture-specific antibiotics were administered for 2 weeks.
   Results: All flaps healed uneventfully except for a minor hematoma that was treated conservatively. All 3 patients were able to return to ambulatory status with regular foot apparel. At last follow-up evaluation, they had no clinical, laboratory, or radiologic signs of osteomyelitis.
   Conclusion: This modified free muscle transfer technique seems to be successful in managing chronic and persistent calcaneal osteomyelitis. Infected and healthy cancellous bone of the calcaneus is removed to eradicate all possible foci that maintain inflammation. The resulting bony defect after the aggressive surgical debridement is sufficiently filled with a well-vascularized muscle that ensures a good wound healing. We consider this method to be a promising treatment option, which needs to be supported by further cases.
C1 [Ghods, Mojtaba; Grabs, Robert; Kersten, Christiane; Chatzopoulos, Peter P.; Geomelas, Menedimos] Hosp Ernst von Bergmann, Dept Plast Reconstruct & Aesthet Surg Surg Hand, D-14467 Potsdam, Germany.
C3 Klinikum Ernst von Bergmann
RP Ghods, M (通讯作者)，Hosp Ernst von Bergmann, Dept Plast Reconstruct & Aesthet Surg Surg Hand, Charlottenstr 72, D-14467 Potsdam, Germany.
EM mgsurgeon@yahoo.de
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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   Cook Jeremy, 2007, J Foot Ankle Surg, V46, P248, DOI 10.1053/j.jfas.2007.03.016
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NR 37
TC 16
Z9 21
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2012
VL 68
IS 6
BP 599
EP 605
DI 10.1097/SAP.0b013e31821ee359
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 949RA
UT WOS:000304592300013
PM 21659847
DA 2026-07-24
ER

PT J
AU Bjarnason, T
   Montgomery, A
   Hlebowicz, J
   Lindstedt, S
   Petersson, U
AF Bjarnason, Thordur
   Montgomery, Agneta
   Hlebowicz, Joanna
   Lindstedt, Sandra
   Petersson, Ulf
TI Pressure at the Bowel Surface during Topical Negative Pressure Therapy
   of the Open Abdomen: An Experimental Study in a Porcine Model
SO WORLD JOURNAL OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; INTRAABDOMINAL HYPERTENSION; ENTEROCUTANEOUS FISTULAS;
   INTERNATIONAL-CONFERENCE; TEMPORARY CLOSURE; VENTRAL HERNIA; WOUND
   CONTROL; MANAGEMENT
AB Background Topical negative pressure (TNP) therapy is increasingly used in open abdomen management. It is not known to what extent this pressure propagates through the dressing to the bowel surface, potentially increasing the risk of bowel fistula formation. The present study in a porcine model was designed to evaluate pressure propagation.
   Methods A commercially available TNP therapy system (ABThera/VAC) was applied in six pigs after laparotomy. Pressure sensors were placed in predetermined positions in the dressing and in the abdominal cavity and the pressure was registered at TNP settings of -50, -75, -100, -125, and -150 mmHg. Next, after infusing 200 ml of saline into the abdomen through a catheter, the amount of fluid drained through the system during 10 min of TNP therapy was registered. Finally, pressure was measured above and below eight layers of paraffin gauzes during TNP therapy.
   Results Observed pressure within the outer two foams and the foam of the visceral protective layer correlated with preset TNP. The median pressure at the bowel surface was between -2 and -10 mmHg, regardless of preset TNP. Median fluid drainage was 95% of the infused fluid at -75 mmHg and 124% at -150 mmHg. Paraffin gauzes had a limited isolating effect, reducing the pressure by 13% in median.
   Conclusions Negative pressure reaching the bowel surface during TNP therapy with the ABThera system is limited for all TNP levels. Reduced therapy pressure does not lead to reduced pressure at the bowel surface. The system drains the abdominal cavity completely of fluid. Paraffin gauzes are of limited value as a means of pressure isolation.
C1 [Bjarnason, Thordur; Montgomery, Agneta; Petersson, Ulf] Lund Univ, Skane Univ Hosp, Dept Surg, S-20502 Malmo, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Skane Univ Hosp, S-20502 Malmo, Sweden.
   [Lindstedt, Sandra] Lund Univ, Dept Thorac Surg, Skane Univ Hosp, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University; Skane University Hospital
RP Bjarnason, T (通讯作者)，Lund Univ, Skane Univ Hosp, Dept Surg, S-20502 Malmo, Sweden.
EM thordur.bjarnason@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
FU Einar and Inga Nilsson Foundation for Surgical Research at the
   Department of Surgery in Malmo; Region of Skane Research grants; KCI
FX The study was supported by grants from the Einar and Inga Nilsson
   Foundation for Surgical Research at the Department of Surgery in Malmo
   and by the Region of Skane Research grants. U. P. received an
   unrestricted (unconditional) research grant from KCI in 2008. The grant
   was not used for this study.
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NR 26
TC 25
Z9 27
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2313
EI 1432-2323
J9 WORLD J SURG
JI World J.Surg.
PD APR
PY 2011
VL 35
IS 4
BP 917
EP 923
DI 10.1007/s00268-010-0937-y
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 745YW
UT WOS:000289208600034
PM 21222123
DA 2026-07-24
ER

PT J
AU Seyhan, H
   Kopp, J
   Polykandriotis, E
   Horch, RE
AF Seyhan, H
   Kopp, J
   Polykandriotis, E
   Horch, RE
TI Vacuum-assisted closure as temporary coverage in the "problem zone hand"
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article; Proceedings Paper
CT Three Nations Congress
CY 2003
CL Nurnberg, GERMANY
DE vacuum therapy; wound closure; reversed cross finger flap
AB Introduction: Vacuum therapy of hand defect problematic due to the interdigital folds and in particular due to the small surface. As a temporary cover in staged procedures, e.g. following excision of tumor-suspicious skin alterations at the hand, and/or at the fingers, the application of vacuum therapy results not only in a sterile, temporary cover of the wound, furthermore it promotes wound conditioning and reduction of the wound area as well as lymph and edema reduction. Patients and Methods: A 75 year old female patient presented herself with a skin alteration at the right dorsal ring finger and the tentative diagnosis of a Morbus Bowen like lesion was raised. Due to the unclear histological status, a staged procedure with excision of the tumour and temporary defect coverage by means of vacuum therapy until final histological evaluation was indicated. We accomplished the radical excision of the unclear skin tumour at the proximal phalanx under preservation of the synovial sheath of the tendon. Subsequently, the wound was temporarily closed with vacuum therapy. Histological examination revealed the complete removal of a solar keratosis. Finally, after 7 days of vacuum therapy as a sterile dressing, with obvious reduction of wound area and simultaneous decrease of edema, the defect was finally covered with a reversed cross finger flap from the adjacent middle finger. The donor site was covered with a full thickness skin graft harvested from the right forearm. The further course was without complication after flap dissection and complete healing. Discussion: Vacuum therapy represents a useful procedure for temporary wound coverage. Especially at hand defects, when nerves, tendons or bones following trauma or staged procedures are exposed, vacuum therapy can be successfully applied utilizing the special surgical "hand glove" technique.
C1 Univ Klinikum Erlangen Nurnberg, Abt Plast & Handchirurg, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Horch, RE (通讯作者)，Univ Klinikum Erlangen Nurnberg, Abt Plast & Handchirurg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM raymund.horch@chir.imed.uni-erlangen.de
RI ; Horch, Raymund E/H-8128-2019
OI Polykaniotis, Elias/0000-0002-8152-6420; Horch, Raymund
   E/0000-0002-6561-2353
CR Horch RE, 2004, ZBL CHIR, V129, pS2, DOI 10.1055/s-2004-822644
   Kneser U, 2005, PLAST RECONSTR SURG, V116, P1910, DOI 10.1097/01.prs.0000189204.71906.c2
   Kopp J, 2005, STRAHLENTHER ONKOL, V181, P124, DOI 10.1007/s00066-005-1291-0
   KOPP J, 2004, ZENTRALBL CHIR S1, V129, P82
NR 4
TC 6
Z9 6
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2006
VL 131
SU 1
BP S33
EP S35
DI 10.1055/s-2006-921436
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 034DB
UT WOS:000236904100009
PM 16575642
DA 2026-07-24
ER

PT J
AU Lan, ZY
   Guo, LP
   Fletcher, A
   Ang, N
   Whitfield-Cargile, C
   Bryan, L
   Welch, S
   Richardson, L
   Cosgriff-Hernandez, E
AF Lan, Ziyang
   Guo, Leopold
   Fletcher, Alan
   Ang, Nicolai
   Whitfield-Cargile, Canaan
   Bryan, Laura
   Welch, Shannara
   Richardson, Lauren
   Cosgriff-Hernandez, Elizabeth
TI Antimicrobial hydrogel foam dressing with controlled release of gallium
   maltolate for infection control in chronic wounds
SO BIOACTIVE MATERIALS
LA English
DT Article
DE Chronic wounds; Hydrogel foam; Antimicrobials wound dressing; Infection
   control; Microsphere
ID RESISTANT STAPHYLOCOCCUS-AUREUS; VACUUM-ASSISTED CLOSURE; MECA GENE;
   BIOFILMS; MANAGEMENT; SILVER; PHARMACOKINETICS; MICROSPHERES;
   ANTIBIOTICS; GENTAMICIN
AB Effective treatment of infection in chronic wounds is critical to improve patient outcomes and prevent severe complications, including systemic infections, increased morbidity, and amputations. Current treatments, including antibiotic administration and antimicrobial dressings, are challenged by the increasing prevalence of antibiotic resistance and patients' sensitivity to the delivered agents. Previous studies have demonstrated the potential of a new antimicrobial agent, Gallium maltolate (GaM); however, the high burst release from the GaMloaded hydrogel gauze required frequent dressing changes. To address this need, we developed a hydrogel foambased wound dressing with GaM-loaded microspheres for sustained infection control. First, the minimal inhibitory and bactericidal concentrations (MIC and MBC) of GaM against two Staphylococcus aureus strains isolated from chronic wounds were identified. No significant adverse effects of GaM on dermal fibroblasts were shown at the MIC, indicating an acceptable selectivity index. For the sustained release of GaM, electrospraying was employed to fabricate microspheres with different release kinetics. Systematic investigation of loading and microsphere size on release kinetics indicated that the larger microsphere size and lower GaM loading resulted in a sustained GaM release profile over the target 5 days. Evaluation of the GaM-loaded hydrogel dressing demonstrated cytocompatibility and antibacterial activities with a zone of inhibition test. An equine distal limb wound model was developed and utilized to demonstrate the efficacy of GaM-loaded hydrogel foam in vivo. This antimicrobial hydrogel foam dressing displayed the potential to combat methicillin-resistant S. aureus (MRSA) infection with controlled GaM release to improve chronic wound healing.
C1 [Lan, Ziyang; Guo, Leopold; Fletcher, Alan; Ang, Nicolai; Cosgriff-Hernandez, Elizabeth] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA.
   [Whitfield-Cargile, Canaan; Richardson, Lauren] Univ Georgia, Dept Large Anim Med, Athens, GA 30602 USA.
   [Bryan, Laura] Texas A&M Univ, Dept Pathobiol, College Stn, TX 77843 USA.
   [Welch, Shannara] Texas A&M Univ, Vet Teaching Hosp, Clin Microbiol Lab, College Stn, TX 77843 USA.
C3 University of Texas System; University of Texas Austin; University
   System of Georgia; University of Georgia; Texas A&M University System;
   Texas A&M University College Station; Texas A&M University System; Texas
   A&M University College Station
RP Cosgriff-Hernandez, E (通讯作者)，107 W Dean Keeton BME Bldg,Room3D, Austin, TX 78712 USA.
EM ziyangl@utexas.edu; leopold.guo@utexas.edu; alan.fletcher@utexas.edu;
   nicolai.ang@utexas.edu; wcana@uga.edu; lbryan@cvm.tamu.edu;
   swelch@exchange.tamu.edu; lr22859@uga.edu; cosgriff.hernandez@utexas.edu
RI ; Bryan, Laura K/ABD-5741-2020; Lan, Ziyang/JMC-2413-2023;
   Cosgriff-Hernandez, Elizabeth/E-6391-2016
OI Whitfield-Cargile, Canaan/0000-0002-9743-8783; Richardson,
   Lauren/0009-0006-4507-0952; Guo, Leopold/0009-0002-6632-2398; Bryan,
   Laura K/0000-0003-0746-9461; 
FU National Institutes of Health [R21 AR076107]
FX This work was supported by National Institutes of Health (Grant No. R21
   AR076107) .
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NR 84
TC 38
Z9 39
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U2 91
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
EI 2452-199X
J9 BIOACT MATER
JI Bioact. Mater.
PD DEC
PY 2024
VL 42
BP 433
EP 448
DI 10.1016/j.bioactmat.2024.08.044
PG 16
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA G7F2O
UT WOS:001318244900001
PM 39308545
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nachira, D
   Calabrese, G
   Senatore, A
   Pontecorvi, V
   Kuzmych, K
   Belletatti, C
   Boskoski, I
   Meacci, E
   Biondi, A
   Raveglia, F
   Bove, V
   Congedo, MT
   Vita, ML
   Santoro, G
   Ciavarella, LP
   Lococo, F
   Punzo, G
   Trivisonno, A
   Petrella, F
   Barbaro, F
   Spada, C
   D'Ugo, D
   Cioffi, U
   Margaritora, S
AF Nachira, Dania
   Calabrese, Giuseppe
   Senatore, Alessia
   Pontecorvi, Valerio
   Kuzmych, Khrystyna
   Belletatti, Claudia
   Boskoski, Ivo
   Meacci, Elisa
   Biondi, Alberto
   Raveglia, Federico
   Bove, Vincenzo
   Congedo, Maria Teresa
   Vita, Maria Letizia
   Santoro, Gloria
   Petracca Ciavarella, Leonardo
   Lococo, Filippo
   Punzo, Giovanni
   Trivisonno, Angelo
   Petrella, Francesco
   Barbaro, Federico
   Spada, Cristiano
   D'Ugo, Domenico
   Cioffi, Ugo
   Margaritora, Stefano
TI How to preserve the native or reconstructed esophagus after perforations
   or postoperative leaks: A multidisciplinary 15-year experience
SO WORLD JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Esophageal perforations; Postoperative leak; Endoscopic vacuum-assisted
   closure therapy; Metal stent; Endoscopic suture; Lateral esophagostomy;
   Autologous emulsified stromal vascular fraction
ID ENDOSCOPIC CLOSURE; ANASTOMOTIC LEAKS; CLIP APPLICATION; MANAGEMENT;
   EFFICACY; ESOPHAGECTOMY; FISTULAS; SURGERY; STENTS
AB BACKGROUND Esophageal perforation or postoperative leak after esophageal surgery remain a life-threatening condition. The optimal management strategy is still unclear. AIM To determine clinical outcomes and complications of our 15-year experience in the multidisciplinary management of esophageal perforations and anastomotic leaks. METHODS A retrospective single-center observational study was performed on 60 patients admitted at our department for esophageal perforations or treated for an anastomotic leak developed after esophageal surgery from January 2008 to December 2023. Clinical outcomes were analyzed, and complications were evaluated to investigate the efficacy and safety of our multidisciplinary management based on the preservation of the native or reconstructed esophagus, when feasible. RESULTS Among the whole series of 60 patients, an urgent surgery was required in 8 cases due to a septic state. Fifty-six patients were managed by endoscopic or hybrid treatments, obtaining the resolution of the esophageal leak/perforation without removal of the native or reconstructed esophagus. The mean time to resolution was 54.95 +/- 52.64 days, with a median of 35.5 days. No severe complications were recorded. Ten patients out of 56 (17.9%) developed pneumonia that was treated by specific antibiotic therapy, and in 6 cases (10.7%) an atrial fibrillation was recorded. Seven patients (12.5%) developed a stricture within 12 months, requiring one or two endoscopic pneumatic dilations to solve the problem. Mortality was 1.7%. CONCLUSION A proper multidisciplinary approach with the choice of the most appropriate treatment can be the key for success in managing esophageal leaks or perforations and preserving the esophagus.
C1 [Nachira, Dania; Calabrese, Giuseppe; Senatore, Alessia; Kuzmych, Khrystyna; Belletatti, Claudia; Meacci, Elisa; Congedo, Maria Teresa; Vita, Maria Letizia; Petracca Ciavarella, Leonardo; Lococo, Filippo; Margaritora, Stefano] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Gen Thorac Surg, Largo A Vito 8, I-00168 Rome, Italy.
   [Pontecorvi, Valerio; Boskoski, Ivo; Bove, Vincenzo; Barbaro, Federico; Spada, Cristiano] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Digest Endoscopy Unit, I-00168 Rome, Italy.
   [Biondi, Alberto] Fdn Policlin Univ Agostino Gemelli IRCCS, Gen Surg Unit, I-00168 Rome, Italy.
   [Raveglia, Federico; Petrella, Francesco] IRCCS San Gerardo Tintori, Dept Thorac Surg, I-20900 Monza, Lombardy, Italy.
   [Santoro, Gloria] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Surg, I-00168 Rome, Italy.
   [Punzo, Giovanni] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Anesthesiol & Intens Care Med, I-00168 Rome, Italy.
   [Trivisonno, Angelo] Assunz Maria Santissima Clin, Dept Plast Surg, I-00135 Rome, Italy.
   [D'Ugo, Domenico] Agostino Gemelli Univ Hosp, Catholic Univ Rome, Dept Surg, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Fondazione IRCCS San Gerardo dei Tintori; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Nachira, D (通讯作者)，Univ Cattolica Sacro Cuore IRCCS, Fdn Policlin Univ Agostino Gemelli, Dept Gen Thorac Surg, Largo A Vito 8, I- 00135 Rome, Italy.
EM dania.nachira@policlinicogemelli.it
RI Boskoski, Ivo/A-9629-2014; meacci, elisa/IQT-4087-2023; Nachira,
   Dania/AAO-4264-2020; Biondi, Alberto/K-4781-2018; Bove,
   Vincenzo/ABD-9730-2020; Kuzmych, Khrystyna/NNG-1141-2025; Barbaro,
   Federico/HNS-1515-2023; Pontecorvi, Valerio/AAB-8594-2022; Petrella,
   Francesco/AAP-6480-2020; Raveglia, Federico/J-9512-2019; D'Ugo,
   Domenico/AAB-7038-2019; Vita, Maria/F-5801-2019; congedo, maria
   teresa/K-8809-2016
OI Punzo, Giovanni/0000-0002-4640-5885; Bellettati,
   Claudia/0009-0000-2458-6657; Kuzmych, Khrystyna/0000-0001-6399-9171;
   Barbaro, Federico/0000-0002-7928-3757; Pontecorvi,
   Valerio/0000-0003-3972-1828; Petracca Ciavarella,
   Leonardo/0000-0002-9659-1014; 
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NR 57
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PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-9366
J9 WORLD J GASTRO SURG
JI World J. Gastrointest. Surg.
PD NOV 27
PY 2024
VL 16
IS 11
DI 10.4240/wjgs.v16.i11.3471
PG 14
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA Q1Q5T
UT WOS:001382518300011
PM 39649190
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Senne, M
   Werner, CR
   Schempf, U
   Thiel, K
   Königsrainer, A
   Wichmann, D
AF Senne, Moritz
   Werner, Christoph R.
   Schempf, Ulrike
   Thiel, Karolin
   Koenigsrainer, Alfred
   Wichmann, Doerte
TI Comparison of Two Endoscopic Therapeutic Interventions as Primary
   Treatment for Anastomotic Leakages after Total Gastrectomy
SO CANCERS
LA English
DT Article
DE esophagojejunal anastomotic leak; oncological gastrectomy; complication
   management; endoscopy
ID VACUUM-ASSISTED CLOSURE; INSUFFICIENCY; PERFORATIONS; MANAGEMENT;
   DEFECTS; LEAKS
AB Simple Summary An esophagojejunal anastomotic leak after oncological gastrectomy is a life-threatening complication. Endoscopic treatment offers the possibility of minimally invasive diagnosis and immediate effective therapy in one session. A retrospective, single-center analysis of two different endoscopic strategies as first-line treatment options was performed. Introduction: An esophagojejunal anastomotic leak following an oncological gastrectomy is a life-threatening complication, and its management is challenging. A stent application and endoscopic negative pressure therapy are possible therapeutic options. A clinical comparison of these strategies has been missing until now. Methods: A retrospective analysis of 14 consecutive patients endoscopically treated for an anastomotic leak after a gastrectomy between June 2014 and December 2019 was performed. Results: The mean time of the diagnosis of the leakage was 7.14 days after surgery. Five patients were selected for a covered stent, and nine patients received endoscopic negative pressure therapy. In the stent group, the mean number of endoscopies was 2.4, the mean duration of therapy was 26 days, and the mean time of hospitalization was 30 days. In patients treated with endoscopic negative pressure therapy, the mean number of endoscopies was 6.0, the mean days of therapy duration was 14.78, and the mean days of hospitalization was 38.11. Treatment was successful in all patients in the stent-based therapy group and in eight of nine patients in the negative pressure therapy group. Discussion: Good clinical results in preserving the anastomosis and providing sepsis control was achieved in all patients. Stent therapy resulted in anastomosis healing with a lower number of endoscopies, a shorter time of hospitalization, and rapid oral nutrition.
C1 [Senne, Moritz; Thiel, Karolin; Koenigsrainer, Alfred; Wichmann, Doerte] Univ Hosp Tubingen, Dept Gen Visceral & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Werner, Christoph R.; Schempf, Ulrike] Univ Hosp Tubingen, Dept Gastroenterol Gastrointestinal Oncol Hepatol, Otfried Muller Str 10, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital
RP Werner, CR (通讯作者)，Univ Hosp Tubingen, Dept Gastroenterol Gastrointestinal Oncol Hepatol, Otfried Muller Str 10, D-72076 Tubingen, Germany.
EM moritz.senne@med.uni-tuebingen.de;
   christoph.werner@med.uni-tuebingen.de;
   ulrike.schempf@med.uni-tuebingen.de; karolin.thiel@med.uni-tuebingen.de;
   alfred.koenigsrainer@med.uni-tuebingen.de;
   doerte.wichmann@med.uni-tuebingen.de
OI , Doerte/0000-0002-8832-5031
FU Open Access Publishing Fund of the University of Tubingen
FX This publication of the research was funded by the Open Access
   Publishing Fund of the University of Tubingen.
CR Bludau M, 2018, SURG ENDOSC, V32, P1906, DOI 10.1007/s00464-017-5883-4
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   Wichmann D, 2022, CANCERS, V14, DOI 10.3390/cancers14040980
   Yuan P, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6024-3
NR 33
TC 9
Z9 10
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN
PY 2022
VL 14
IS 12
AR 2982
DI 10.3390/cancers14122982
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 2M1EV
UT WOS:000817452800001
PM 35740645
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sandra-Petrescu, F
   Tzatzarakis, E
   Kähler, G
   Reissfelder, C
   Herrle, F
AF Sandra-Petrescu, Flavius
   Tzatzarakis, Emmanouil
   Kaehler, Georg
   Reissfelder, Christoph
   Herrle, Florian
TI Management of colorectal anastomotic leakage using endoscopic negative
   pressure therapy with or without protective ostomy: a retrospective
   study
SO INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
LA English
DT Article
DE Vacuum therapy; Colorectal anastomosis; Leak; Colorectal surgery; Lack
   of protective ostomy; Management algorithm
ID VACUUM-ASSISTED CLOSURE; LONG-TERM EFFICACY; RECTAL-CANCER; ANTERIOR
   RESECTION; SURGERY; STOMA
AB Purpose Management of colorectal anastomotic leakage (AL) is patient-oriented and requires an interdisciplinary approach. We analyzed the management of AL according to its severity and presence of ostomy and proposed a therapy algorithm. Methods We identified all patients who underwent colorectal surgery and developed an AL in our clinic between 2012 and 2017. The management of AL was retrospectively analyzed according to the severity grade: asymptomatic (A), requesting interventional or antibiotic therapy (B), undergoing re-operation (C). The groups were compared according to the leakage characteristics, presence of ostomy, and patient clinical conditions. Results We identified 784 consecutive patients meeting the inclusion criteria. Of these, 10.8% experienced an AL (A = 18%, B = 48%, and C = 34%). The rate of successful ostomy closure was 100% (A), 68% (B), and 62% (C), respectively. Within group B, 91% of the patients were treated solely by endoscopic negative pressure therapy (ENPT), whereas 37% of the patients within group C required ENPT in addition to surgery. Seven cases within group B (17%) required no protective ostomy (nOB) during ENPT which was itself shorter and required less cycles in comparison to group B with ostomy (OB) (p = 0.017 and 0.111, respectively). Moreover, the leakage distance to anal verge was higher in the OB subgroup (p < 0.001). Conclusion ENPT for the treatment of colorectal AL is efficient in combination with operative revision or protective ostomy. In selected patients, it is feasible also in the absence of a protective ostomy.
C1 [Sandra-Petrescu, Flavius; Tzatzarakis, Emmanouil; Reissfelder, Christoph; Herrle, Florian] Univ Klinikum Mannheim, Chirurg Klin, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
   [Kaehler, Georg] Univ Klinikum Mannheim, Chirurg Klin, Interdisziplinare Endoskopie, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg
RP Sandra-Petrescu, F (通讯作者)，Univ Klinikum Mannheim, Chirurg Klin, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany.
EM flavius.sandra-petrescu@umm.de; emmanouil.tzatzarakis@umm.de;
   georg.kaehler@umm.de; christoph.reissfelder@umm.de;
   florian.herrle@umm.de
RI Reissfelder, Christoph/HRA-4846-2023
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Arezzo A, 2015, DIGEST LIVER DIS, V47, P342, DOI 10.1016/j.dld.2014.12.003
   Chopra SS, 2009, SURGERY, V145, P182, DOI 10.1016/j.surg.2008.09.012
   Daams F, 2012, DIGEST SURG, V29, P516, DOI 10.1159/000346348
   Herrle F, 2016, DIS COLON RECTUM, V59, P281, DOI 10.1097/DCR.0000000000000545
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   Kouladouros K, 2021, SCAND J GASTROENTERO, V56, P193, DOI 10.1080/00365521.2020.1861645
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   Mees ST, 2008, DIS COLON RECTUM, V51, P404, DOI 10.1007/s10350-007-9141-z
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   Phitayakorn R, 2008, WORLD J SURG, V32, P1147, DOI 10.1007/s00268-008-9468-1
   Platell C, 2007, COLORECTAL DIS, V9, P71, DOI 10.1111/j.1463-1318.2006.01002.x
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   von Bernstorff W, 2009, INT J COLORECTAL DIS, V24, P819, DOI 10.1007/s00384-009-0673-7
   Weidenhagen R, 2008, SURG ENDOSC, V22, P1818, DOI 10.1007/s00464-007-9706-x
NR 24
TC 7
Z9 9
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-1958
EI 1432-1262
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD OCT
PY 2021
VL 36
IS 10
BP 2261
EP 2269
DI 10.1007/s00384-021-04011-8
EA AUG 2021
PG 9
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA UP6II
UT WOS:000690702200002
PM 34455472
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Rollo, G
   De Angelis, P
   Torroni, F
   Balassone, V
   Contini, ACI
   Faraci, S
   Romeo, EF
   Oglio, L
   Caldaro, T
AF Rollo, Giovanni
   De Angelis, Paola
   Torroni, Filippo
   Balassone, Valerio
   Contini, Anna Chiara Iolanda
   Faraci, Simona
   Romeo, Erminia Francesca
   Dall Oglio, Luigi
   Caldaro, Tamara
TI Replogle Modified Endoscopic Vacuum-Assisted Closure (EVAC) Therapy: A
   New Strategy to Treat Anastomotic Leakage and Esophageal Perforation
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE EVAC therapy; Anastomotic leakage; Esophageal perforation; Children;
   Pediatric; Endoscopy
ID MANAGEMENT; RESECTION; OPTIONS
AB Background: Anastomotic leakage (AL) and esophageal perforation are life -threatening complications following surgery or endoscopic dilations. "Replogle modified EVAC therapy" consists of placing a Replogle tube directly into the lumen or within an abscess cavity and remove by suction all intra-cavity fluids and secretion with a continuous low-pressure suction, promoting granulation tissue proliferation, thereby gradually decreasing the cavity size. The aim of our study was to evaluate the technical feasibility, safety, and efficacy of this technique in pediatric patients. Methods: A retrospective review charts of consecutive pediatric patients that were treated with "Replogle modified EVAC therapy" at our pediatric referral center between 2013 and 2022 was conducted. The clinical, endoscopic, radiological, and surgical information and data of patients were collected and revised as well as their follow-up and outcomes. Results: Ten patients (6/10 male; mean age: 7.8 y.o., range: 1.1-18 y.o.) were treated using the "Replogle modified EVAC therapy". Four out of ten patients developed esophageal perforations after endoscopic procedures. Six out of the ten enrolled patients had AL complications after surgical operations. All patients were successfully treated. There were no technical failures or complications with device placement. Mean treatment duration was 16 days (range 7-41 days). No additional treatment was needed for complete leak resolution. Conclusions: "Replogle modified EVAC therapy" represents a promising and mini -invasive method to treat esophageal perforations and post -surgical leak in the paediatric age group. In our experience, the use of this technique was safe, effective, and particularly well suited also in complex paediatric patients. Level of evidence: IV. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Rollo, Giovanni] Univ Roma Tor Vergata, Rome, Italy.
   [De Angelis, Paola; Torroni, Filippo; Faraci, Simona; Romeo, Erminia Francesca] Bambino Gesu Pediat Hosp, Gastroenterol & Nutr Unit, IRCCS, Rome, Italy.
   [Rollo, Giovanni; Balassone, Valerio; Contini, Anna Chiara Iolanda; Dall Oglio, Luigi; Caldaro, Tamara] Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS Rome, Rome, Italy.
   [Rollo, Giovanni] Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS, Rome, Italy.
C3 University of Rome Tor Vergata; IRCCS Bambino Gesu; IRCCS Bambino Gesu;
   IRCCS Bambino Gesu
RP Rollo, G (通讯作者)，Bambino Gesu Pediat Hosp, Digest Endoscopy & Surg Unit, IRCCS, Rome, Italy.
EM giovanni.rollo@opbg.net
RI Romeo, Erminia/AAA-7473-2020; torroni, filippo/AAA-6167-2020; Balassone,
   Valerio/AAW-6795-2021; caldaro, tamara/AAA-6015-2020; faraci,
   simona/AAA-7421-2020; Rollo, Giovanni/JKH-6429-2023
OI Balassone, Valerio/0000-0001-5398-4275; Rollo,
   Giovanni/0009-0004-7742-8838
FU Italian Ministry of Health with Current Research funds
FX This work was supported by the Italian Ministry of Health with "Current
   Research funds ". This study did not receive other types of grants from
   funding agencies in the public, commercial, or nonpro fit sectors. The
   authors have no financial relationships or con flicts of interest to
   disclose.
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NR 17
TC 4
Z9 4
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD MAR
PY 2024
VL 59
IS 3
BP 432
EP 436
DI 10.1016/j.jpedsurg.2023.09.043
EA FEB 2024
PG 5
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA IR6I8
UT WOS:001168092400001
PM 37949689
DA 2026-07-24
ER

PT J
AU Lenz, Y
   Gross, R
   Penna, V
   Bannasch, H
   Stark, GB
   Eisenhardt, SU
AF Lenz, Yvonne
   Gross, Ruth
   Penna, Vincenzo
   Bannasch, Holger
   Stark, G. Bjoern
   Eisenhardt, Steffen U.
TI Evaluation of the Implantable Doppler Probe for Free Flap Monitoring in
   Lower Limb Reconstruction
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE lower limb reconstruction; postoperative monitoring; implantable Doppler
   probe; free muscle flap; microsurgery
ID FREE-TISSUE TRANSFERS; EXTREMITY FREE-FLAPS; NEAR-INFRARED SPECTROSCOPY;
   MICROVASCULAR FREE FLAPS; VACUUM-ASSISTED CLOSURE; COOK-SWARTZ DOPPLER;
   FAILED FREE FLAPS; MICRODIALYSIS; EXPERIENCE; SALVAGE
AB Background Timely reexploration and reanastomoses can salvage failing free flaps. The use of the implantable Doppler probe provides direct evidence of vascular impairment of the microvascular anastomoses and allows for postoperative NPWT. The aim of this retrospective study was to compare the Doppler probe to conventional monitoring techniques for free flap monitoring in lower limb reconstruction and to identify risk factors for perfusion disturbance and reexploration.
   Methods All patients receiving free muscle flap reconstruction for lower limb soft tissue defects at our department from 2000 to 2013 were included, and all adverse events, timely detection of perfusion problems, and outcome of revision surgery were assessed by chart analysis.
   Results For lower limb reconstruction, 110 free muscle transfers were performed of which 41 muscle flaps were conventionally monitored and 69 flaps were monitored using the implantable Doppler probe. In 18 cases, the free muscle flaps needed revision because of perfusion disturbances. The salvage rate was 80% with monitoring by the implantable Doppler probe compared with 62.5% using conventional monitoring methods resulting in success rates of 95.7 and 92.7%, respectively.
   Conclusion The use of the implantable Cook-Swartz Doppler probe represents a safe monitoring method for lower limb reconstruction, which allows for the additional use of NPWT. Higher salvage and revision success rates can be attributed to an earlier detection of perfusion impairment. However, a larger patient cohort is necessary to verify superiority over conventional postoperative monitoring.
C1 [Lenz, Yvonne; Gross, Ruth; Penna, Vincenzo; Bannasch, Holger; Stark, G. Bjoern; Eisenhardt, Steffen U.] Univ Freiburg, Dept Plast & Hand Surg, Med Ctr, Hugstetter Str 55, D-79106 Freiburg, Germany.
C3 University of Freiburg
RP Lenz, Y (通讯作者)，Univ Freiburg, Dept Plast & Hand Surg, Med Ctr, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM yvonne.lenz@uniklinik-freiburg.de
RI Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Eisenhardt, Steffen Ulrich/0000-0003-4471-3160
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NR 40
TC 23
Z9 24
U1 0
U2 1
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD MAR
PY 2018
VL 34
IS 3
DI 10.1055/s-0037-1608628
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FX1NO
UT WOS:000425819200009
PM 29179224
DA 2026-07-24
ER

PT J
AU Volk, SW
   Bohling, MW
AF Volk, Susan W.
   Bohling, Mark W.
TI Comparative wound healing - Are the small animal veterinarian's clinical
   patients an improved translational model for human wound healing
   research?
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID CLEAN-CONTAMINATED WOUNDS; VACUUM-ASSISTED CLOSURE; EPIDEMIOLOGIC
   EVALUATION; INFECTION-RATES; DOGS; CATS; SKIN; BITE; CONTRACTION;
   MANAGEMENT
AB Despite intensive research efforts into understanding the pathophysiology of both chronic wounds and scar formation, and the development of wound care strategies to target both healing extremes, problematic wounds in human health care remain a formidable challenge. Although valuable fundamental information regarding the pathophysiology of problematic wounds can be gained from in vitro investigations and in vivo studies performed in laboratory animal models, the lack of concordance with human pathophysiology has been cited as a major impediment to translational research in human wound care. Therefore, the identification of superior clinical models for both chronic wounds and scarring disorders should be a high priority for scientists who work in the field of human wound healing research. To be successful, translational wound healing research should function as an intellectual ecosystem in which information flows from basic science researchers using in vitro and in vivo models to clinicians and back again from the clinical investigators to the basic scientists. Integral to the efficiency of this process is the incorporation of models which can accurately predict clinical success. The aim of this review is to describe the potential advantages and limitations of using clinical companion animals (primarily dogs and cats) as translational models for cutaneous wound healing research by describing comparative aspects of wound healing in these species, common acute and chronic cutaneous wounds in clinical canine and feline patients, and the infrastructure that currently exists in veterinary medicine which may facilitate translational studies and simultaneously benefit both veterinary and human wound care patients.
C1 [Volk, Susan W.] Univ Penn, Dept Clin Studies & Anim Biol, Sch Vet Med, Philadelphia, PA 19104 USA.
   [Bohling, Mark W.] Lincoln Mem Univ, Coll Vet & Comparat Med, Harrogate, TN USA.
C3 University of Pennsylvania; Lincoln Memorial University
RP Volk, SW (通讯作者)，Univ Penn, Dept Clin Studies & Anim Biol, Sch Vet Med, 312 Hill Pavil,380 S Univ Ave, Philadelphia, PA 19104 USA.
EM swvolk@vet.upenn.edu
FU NIAMS [K08AR053945]
FX No external funding was received for this perspective review. SWV would
   like to acknowledge support from NIAMS (K08AR053945). The authors wish
   to thank Laura K. S. Parnell for the original idea of this mini-review
   as well as critical review in its preparation. This work was presented
   at the 2012 annual meeting of the Wound Healing Society in Atlanta GA.
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NR 69
TC 72
Z9 84
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2013
VL 21
IS 3
BP 372
EP 381
DI 10.1111/wrr.12049
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 137NZ
UT WOS:000318444000005
PM 23627643
DA 2026-07-24
ER

PT J
AU Li, SF
   Zhao, JY
   Liu, JP
   Xiang, F
   Lu, DB
   Liu, BY
   Xu, J
   Zhang, HM
   Zhang, Q
   Li, XW
   Yu, RC
   Chen, MJ
   Wang, X
   Wang, Y
   Chen, B
AF Li, Shufa
   Zhao, Jianyong
   Liu, Jianping
   Xiang, Fei
   Lu, Debin
   Liu, Baoying
   Xu, Jing
   Zhang, Huimin
   Zhang, Qian
   Li, Xianwen
   Yu, Richeng
   Chen, Mingjun
   Wang, Xia
   Wang, Ye
   Chen, Bing
TI Prospective randomized controlled study of a Chinese herbal medicine
   compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: A
   preliminary report
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Tangzu Yuyang Ointment; Traditional Chinese medicine; Chinese herbal
   medicine; Complementary and alternative medicine; Diabetic foot ulcer
ID VACUUM-ASSISTED-CLOSURE; LOWER-EXTREMITY ULCERS; GUIDELINES; MANAGEMENT;
   AMPUTATION; THERAPY
AB Aim of the study: The purpose of this study was to evaluate the efficacy and safety of a topical Chinese herbal medicine (CHM) compound Tangzu Yuyang Ointment (TYO) for treatment of chronic diabetic foot ulcers.
   Materials and methods: This multi-center, prospective, randomized, controlled and add-on clinical trial was conducted at seven centers in the China mainland. Fifty-seven patients with chronic diabetic foot ulcers of Wagner's ulcer grade 1-3 were enrolled in this study. Patients who were randomly assigned to the control group (n = 28) received standard wound therapy (SWT), whereas those randomized to the treatment group (n = 28) received SWT plus topical TYO. Only 48 patients who finished 24 weeks of observations were entered for data analysis.
   Results: The TYO and SWT groups were comparable for baseline characteristics. Ulcer improvement was 79.2% in the TYO group and 41.7% in the SWT group (P = 0.017) at 12 weeks, and 91.7% vs. 62.5% (P = 0.036) at 24 weeks. The number of ulcers that were completely healed at 4, 12 and 24 weeks was similar in both groups, as were the numbers of adverse events. Healing time was 96 +/- 56 days (n = 19) in the TYO group and 75 +/- 53 days (n = 14) in the SWT group (P = 0.271).
   Conclusion: TYO plus SWT is more effective than SWT in the management of chronic diabetic foot ulcers and has few side-effects. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Li, Shufa; Lu, Debin; Liu, Baoying; Xu, Jing; Chen, Bing] Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China.
   [Li, Shufa; Xiang, Fei] Guiyang First Peoples Hosp, Dept Endocrinol, Guiyang, Peoples R China.
   [Zhao, Jianyong] Guiyang First Peoples Hosp, Dept Normal Surg, Guiyang, Peoples R China.
   [Liu, Jianping; Zhang, Huimin] Beijing Univ Chinese Med, Ctr Evidence Based Med, Beijing, Peoples R China.
   [Zhang, Qian] Guiyang Med Coll, Affiliated Hosp 2, Dept Endocrinol, Kaili, Peoples R China.
   [Li, Xianwen] Zunyi Med Coll, Affiliated Hosp, Dept Endocrinol, Zunyi, Peoples R China.
   [Yu, Richeng] Peoples Hosp Guizhou Prov, Dept Endocrinol, Guiyang, Peoples R China.
   [Chen, Mingjun] Fourth Peoples Hosp Guiyang City, Dept Endocrinol, Guiyang, Peoples R China.
   [Wang, Xia] Hosp Chinese Peoples Liberat Army, Dept Endocrinol, Guiyang, Peoples R China.
   [Wang, Ye] Chinese Acad Sci, Guiyang, Peoples R China.
   [Wang, Ye] Key Lab Chem Nat Prod, Guiyang, Guizhou Prov, Peoples R China.
C3 Army Medical University; Beijing University of Chinese Medicine; Guizhou
   Medical University; Zunyi Medical University; Chinese Academy of
   Sciences
RP Chen, B (通讯作者)，30 Gaotanyanzheng St, Chongqing 400038, Peoples R China.
EM shufali@163.com; zjy123abc@163.com; jianping_l@hotmail.com;
   5833125@163.com; ldb2005056@yahoo.com.cn; lhx96171@tom.com;
   jing_jing_629@163.com; 64286195@sohu.com; klzq418@sina.com;
   nfmnk2007@yahoo.com.cn; ryc0926@tom.com; 21847705@qq.com;
   shanshi040@sina.com; Wangye.cn@hotmail.com; binchen023@yahoo.com.cn
RI zhang, huimin/HMP-4757-2023
FU Third Military Medical University (Chongqing, China) [2009XLC07];
   Science and Technology Bureau of Guiyang City (Gui Zhou, China)
   [2006-35-1]
FX This study was supported by clinical research funds of Third Military
   Medical University (Chongqing, China, fund no. 2009XLC07) and Science
   and Technology Bureau of Guiyang City (Gui Zhou, China, fund no.
   2006-35-1). We thank all the clinical staff who performed clinical
   observation.
CR Ahn Andrew C, 2007, Acupunct Med, V25, P11
   [Anonymous], PHARM CLIN APPL HDB
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NR 30
TC 42
Z9 48
U1 1
U2 46
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 27
PY 2011
VL 133
IS 2
BP 543
EP 550
DI 10.1016/j.jep.2010.10.040
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 756IE
UT WOS:000290004100037
PM 21129474
DA 2026-07-24
ER

PT J
AU Utz, ER
   Elster, EA
   Tadaki, DK
   Gage, F
   Perdue, PW
   Forsberg, JA
   Stojadinovic, A
   Hawksworth, JS
   Brown, TS
AF Utz, Edward R.
   Elster, Eric A.
   Tadaki, Douglas K.
   Gage, Frederick
   Perdue, Philip W.
   Forsberg, Jonathan A.
   Stojadinovic, Alexander
   Hawksworth, Jason S.
   Brown, Trevor S.
TI Metalloproteinase Expression is Associated with Traumatic Wound Failure
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Luminex; MMP-2; MMP-3; MMP-7; effluent; multiplex; dehiscence; acute
   wound; VAC
ID OPERATION IRAQI FREEDOM; GINGIVAL CREVICULAR FLUID; MATRIX
   METALLOPROTEINASES; EXTREMITY WOUNDS; ENDURING FREEDOM; THERAPY; BLAST;
   MECHANISMS; INJURIES; BIOLOGY
AB Background. Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing.
   Methods. Thirty-eight wounds in 25 patients with traumatic extremity combat wounds were prospectively studied. Surgical debridement with vacuum-assisted closure (VAC) device application was repeated every 48 to 72h until surgical wound closure. Wound effluent and patient serum were collected at each wound debridement and analyzed for five matrix metalloproteinases using the Luminex multiplex system; Millipore Corp, Billerica, MA. The primary outcome was wound healing within 30 d of definitive wound closure. Impairment was defined as delayed wound closure (>21 d from injury) or wound dehiscence. MMP expression was compared between impaired and normal healing wounds.
   Results. Elevated levels of serum MMP-2 and MMP-7 and reduced levels of effluent MMP3 were seen in impaired wounds (n = 9) compared with wounds that healed (n = 29; P<0.001). Receiver operating characteristic (ROC) curve analysis yielded area-under-the-curve (AUC) of 0.744, 0.783, and 0.805, respectively.
   Conclusions. Impaired wound healing is characterized by pro-inflammatory MMP-2 and MMP-7. Serum and effluent concentrations of MMP-2, MMP-3, and MMP-7 can effectively predict the outcome of traumatic war wounds and can potentially provide decision-supportive, objective evidence for the timing of wound closure. Published by Elsevier Inc.
C1 [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Gage, Frederick; Forsberg, Jonathan A.; Hawksworth, Jason S.; Brown, Trevor S.] USN, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA.
   [Stojadinovic, Alexander; Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
   [Utz, Edward R.; Elster, Eric A.; Tadaki, Douglas K.; Forsberg, Jonathan A.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
   [Elster, Eric A.; Perdue, Philip W.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA.
   [Forsberg, Jonathan A.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed & Rehabil, Bethesda, MD USA.
C3 United States Department of Defense; United States Navy; Walter Reed
   National Military Medical Center; United States Department of Defense;
   United States Army; Uniformed Services University of the Health Sciences
   - USA; Walter Reed National Military Medical Center; Walter Reed
   National Military Medical Center
RP Brown, TS (通讯作者)，USN, Med Res Ctr, Regenerat Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Trevor.Brown@med.navy.mil
RI Tadaki, Douglas/B-1623-2008; Forsberg, Jonathan/K-2116-2012; Brown,
   Trevor/F-7392-2015; Elster, Eric/G-2332-2010
OI Forsberg, Jonathan/0000-0003-3835-0615; Stojadinovic,
   Alexander/0000-0002-2829-8967; Brown, Trevor/0000-0001-7042-785X;
   Elster, Eric/0000-0002-0981-2748
FU U.S. Navy Bureau of Medicine and Surgery [PE 0604771 N]; Alpha Omega
   Alpha Carolyn L. Kuckein Student Research Fellowship
FX The multidisciplinary care of these patients would not have been
   possible without the dedicated efforts of everyone at NNMC. Both
   civilian and military personnel have rendered skilled and compassionate
   care for these casualties. All of our efforts are dedicated to those who
   have been placed in harm's way for the good of our nation. This effort
   was supported (in part) by the U.S. Navy Bureau of Medicine and Surgery
   under the Medical Development Program (PE 0604771 N) and in part by an
   Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship.
CR Armstrong DG, 2002, J AM PODIAT MED ASSN, V92, P12, DOI 10.7547/87507315-92-1-12
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NR 27
TC 70
Z9 84
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD APR
PY 2010
VL 159
IS 2
BP 633
EP 639
DI 10.1016/j.jss.2009.08.021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 575MU
UT WOS:000276072000005
PM 20056248
DA 2026-07-24
ER

PT J
AU Berlth, F
   Wichmann, D
   Fusco, S
   Mihaljevic, A
AF Berlth, Felix
   Wichmann, Doerte
   Fusco, Stefano
   Mihaljevic, Andre
TI Anastomotic leakage following surgical resection in the upper
   gastrointestinal tract
SO CHIRURGIE
LA German
DT Review
DE Gastrectomy; Esophagectomy; Endoscopy; Vacuum therapy; Endoluminal metal
   stents; Gastrectomy; Esophagectomy; Endoscopy; Vacuum therapy;
   Endoluminal metal stents
ID VACUUM-ASSISTED CLOSURE; THERAPY; MANAGEMENT
AB Surgical resection is the consistent component of curative treatment strategies for primary malignant diseases of the stomach and the esophagus. The placement of anastomoses for the necessary reconstruction still accounts for substantial morbidity and in the case of a failure to rescue also for mortality, especially for esophagojejunostomy and esophagogastrostomy. The diagnostics of anastomotic leakage routinely involve computed tomography and endoscopy and timely performance appears to be essential. Endoscopy can simultaneously initiate the essential treatment step. A major reason for the improvement of postoperative outcomes after resection in the upper gastrointestinal tract in the last decades is the successful and mostly endoscopically performed management of anastomotic leakage, whereby different endoscopic treatment options are now available. Endoscopic vacuum therapy has become established as the standard, normally with an endoscopic vacuum sponge technique but is also now supplemented by a combination system of vacuum sponge and stent. Furthermore, a foil-coated multiple lumen nasogastric tube represents another available option, which can possibly especially be used as a prophylactic measure. The longest established endoscopic therapy option for anastomotic leaks, the endoluminal metal stent, has been replaced as the standard by the vacuum treatment but is still used in suitable situations. Additionally, there are endoscopic suture devices that are currently only used very occasionally. Surgical revision is always available as treatment escalation but is only recommended for very early occurrences and possibly technically related anastomotic leakage and in the case of failure of endoscopic treatment. This article describes and summarizes the diagnostics and treatment of anastomotic leakages after surgical procedures of the upper gastrointestinal tract.
C1 [Berlth, Felix; Mihaljevic, Andre] Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Allgemein Viszeral & Transplantationschirurgi, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
   [Wichmann, Doerte; Fusco, Stefano] Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Gastroenterol Hepatol & Infektiol & Geriatrie, Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; Eberhard Karls University of Tubingen; Eberhard Karls
   University Hospital
RP Berlth, F (通讯作者)，Eberhard Karls Univ Tubingen, Univ Klinikum Tubingen, Klin Allgemein Viszeral & Transplantationschirurgi, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.
EM felix.berlth@med.uni-tuebingen.de
RI Fusco, Stefano/JYQ-3117-2024
OI Fusco, Stefano/0000-0001-6093-4567
CR Baum P, 2019, DTSCH ARZTEBL INT, V116, P739, DOI 10.3238/arztebl.2019.0739
   Berlet M, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1032443
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   Bludau M, 2014, SURG ENDOSC, V28, P896, DOI 10.1007/s00464-013-3244-5
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2731-6971
EI 2731-698X
J9 CHIRURGIE
JI Chirurgie
PD NOV
PY 2024
VL 95
IS 11
BP 871
EP 877
DI 10.1007/s00104-024-02174-y
EA SEP 2024
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J8F3F
UT WOS:001319726600002
PM 39316181
DA 2026-07-24
ER

PT J
AU Lesko, RP
   Cheah, MA
   Sarmiento, S
   Cooney, CM
   Cooney, DS
AF Lesko, Robert P.
   Cheah, Michael A.
   Sarmiento, Samuel
   Cooney, Carisa M.
   Cooney, Damon S.
TI Postoperative Complications of Panniculectomy and Abdominoplasty A
   Retrospective Review
SO ANNALS OF PLASTIC SURGERY
LA English
DT Review
DE abdominoplasty; body contouring; complication rates; panniculectomy
ID VACUUM-ASSISTED CLOSURE; SURGERY; TRENDS
AB Background: Recent studies of panniculectomy outcomes have reported variable complication rates ranging from 8.65% to 56%. Meanwhile, reported abdominoplasty complication rates are considerably lower (similar to 4%). This discrepancy may be attributable to inaccurate inclusion of abdominoplasty patients in panniculectomy cohorts. We performed the current study to better characterize panniculectomy complication rates at a large tertiary care center.
   Methods: We performed a retrospective review of patients who underwent abdominoplasty or panniculectomy at the Johns Hopkins Hospitals between 2010 and 2017. Patients were identified by Common Procedural Terminology codes (15847/17999, 15830) confirmed via the operative note. We examined postoperative complication rates including surgical site infection, seroma formation, wound dehiscence, readmission/reoperation, and postoperative length of stay (LOS). We used parametric and nonparametric methods to determine differences between abdominoplasty and panniculectomy outcomes, as well as logistic regression analysis to evaluate factors associated with patient outcomes following panniculectomy.
   Results: Of the 306 patients included, 103 underwent abdominoplasty while 203 underwent panniculectomy. Initial complication rates following abdominoplasty and panniculectomy were 1.94% and 12.8%, respectively (P= 0.002). Thirty-day complication rates were 9.7% for abdominoplasty and 21.2% for panniculectomy (P= 0.012). The median LOS was 1 day (interquartile range, 0-1 day) for abdominoplasty and 2 days (interquartile range, 1-4 days) for panniculectomy (P= 0.002). No statistically significant differences in complication rates at 6 months and 1 year were observed.
   Conclusions: Panniculectomy offers many functional benefits including improved hygiene and enhanced mobility. However, this study demonstrates that panniculectomy patients may have significantly higher complication rates initially and 30 days postoperatively and longer LOS than individuals undergoing abdominoplasty.
C1 [Lesko, Robert P.; Cheah, Michael A.; Sarmiento, Samuel; Cooney, Carisa M.; Cooney, Damon S.] Johns Univ, Dept Plast & Reconstruct Surg, Sch Med, Baltimore, MD USA.
   [Cheah, Michael A.] Inova Fairfax Med Ctr, Dept Surg, Falls Church, VA USA.
C3 Inova Fairfax Hospital
RP Cooney, DS (通讯作者)，Johns Hopkins Univ, Dept Plast & Reconstruct Surg, Sch Med, 601 N Caroline St,JHOC 8161, Baltimore, MD 21287 USA.
EM dcooney2@jhmi.edu
RI Sarmiento, Samuel/AAE-8364-2022; Cooney, Damon/J-4762-2014
CR Acarturk TG, 2004, ANN PLAS SURG, V53, P360, DOI 10.1097/01.sap.0000135139.33683.2f
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   Zemlyak AY, 2012, J SURG RES, V177, P387, DOI 10.1016/j.jss.2012.06.029
   Zuelzer HB, 2010, ANN PLAS SURG, V64, P598, DOI 10.1097/SAP.0b013e3181cf9f9e
NR 22
TC 20
Z9 27
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD SEP
PY 2020
VL 85
IS 3
BP 285
EP 289
DI 10.1097/SAP.0000000000002220
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NF8LY
UT WOS:000563545500017
PM 32788565
DA 2026-07-24
ER

PT J
AU Wyckman, A
   Abdelrahman, I
   Steinvall, I
   Zdolsek, J
   Granfeldt, H
   Sjöberg, F
   Nettelblad, H
   Elmasry, M
AF Wyckman, Alexander
   Abdelrahman, Islam
   Steinvall, Ingrid
   Zdolsek, Johann
   Granfeldt, Hans
   Sjoberg, Folke
   Nettelblad, Hans
   Elmasry, Moustafa
TI Reconstruction of sternal defects after sternotomy with postoperative
   osteomyelitis, using a unilateral pectoralis major advancement muscle
   flap
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OPEN-HEART-SURGERY; VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY
   MEDIASTINITIS; WOUND-INFECTION; MANAGEMENT
AB Background: The pectoralis major flap, which is usually harvested bilaterally, is considered a workhorse flap in the reconstruction of sternal defects. After a median sternotomy for open heart surgery, 1%-3% of patients develop deep infection and dehiscence of the sternal wound, some of which will eventually require reconstructive surgery. Our aim was to describe the clinical feasibility and associated complications of the unilateral pectoralis major advancement flap in the reconstruction of sternal defects. Methods: A retrospective analysis of all adult patients who were operated on using a unilateral pectoralis major flap for reconstruction of the chest wall at the Linkoping University Hospital during 2008-18 was made using data retrieved from medical records. Results: Forty-three patients had reconstructions with unilateral pectoralis major flaps. Three flaps failed completely, and another 10 patients developed complications that required further operation. The factors that were independently associated with loss of the flaps and complications were: older age, male sex, the number of different antibiotics used, and a long duration of treatment with negative wound pressure. Fewer wound revisions before the reconstruction resulted in more complications. The factors that were independently associated with prolonged time to complete healing were emergency reoperation after the initial operation and complications after reconstruction. Conclusion: The unilateral pectoralis major advancement flap has proved to be a useful technique in the reconstruction of most sternal defects after sternal wound infection in older patients. There is, however, need for a follow-up study on a larger number of procedures to evaluate the long-term outcome compared with other methods of sternal reconstruction.
C1 [Wyckman, Alexander; Abdelrahman, Islam; Steinvall, Ingrid; Zdolsek, Johann; Sjoberg, Folke; Nettelblad, Hans; Elmasry, Moustafa] Linkoping Univ, Dept Hand Surg Plast Surg & Burns, Linkoping, Sweden.
   [Wyckman, Alexander; Abdelrahman, Islam; Steinvall, Ingrid; Zdolsek, Johann; Sjoberg, Folke; Nettelblad, Hans; Elmasry, Moustafa] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
   [Abdelrahman, Islam] Suez Canal Univ, Surg Dept, Plast Surg Unit, Ismailia, Egypt.
   [Granfeldt, Hans] Linkoping Univ, Dept Thorac & Vasc Surg Ostergotland, Linkoping, Sweden.
   [Granfeldt, Hans] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
C3 Linkoping University; Linkoping University; Egyptian Knowledge Bank
   (EKB); Suez Canal University; Linkoping University; Linkoping University
RP Wyckman, A (通讯作者)，Linkoping Univ, Dept Hand Surg Plast Surg & Burns, Linkoping, Sweden.; Wyckman, A (通讯作者)，Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
EM Alexander.Wyckman@regionostergotland.se
RI Abdelrahman, Islam/I-1341-2019; Steinvall, Ingrid/I-5954-2019
OI Abdelrahman, Islam/0000-0002-2500-728X; Steinvall,
   Ingrid/0000-0002-8027-9632
FU Linkoping University
FX Open access funding provided by Linkoping University.
CR Abu-Omar Y, 2017, EUR J CARDIO-THORAC, V51, P10, DOI 10.1093/ejcts/ezw326
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   Zahiri HR, 2013, ANN PLAS SURG, V70, P211, DOI 10.1097/SAP.0b013e3182367dc5
   Zeitani J, 2013, EUR J CARDIO-THORAC, V43, pE144, DOI 10.1093/ejcts/ezt080
NR 22
TC 10
Z9 16
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 20
PY 2020
VL 10
IS 1
AR 8380
DI 10.1038/s41598-020-65398-y
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LY3YG
UT WOS:000540464700002
PM 32433505
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Santoro, G
   Braidotti, P
   Gregori, F
   Santoro, A
   Domenicucci, M
AF Santoro, Giorgio
   Braidotti, Piero
   Gregori, Fabrizio
   Santoro, Antonio
   Domenicucci, Maurizio
TI Traumatic Sacral Fractures: Navigation Technique in Instrumented
   Stabilization
SO WORLD NEUROSURGERY
LA English
DT Article
DE Classification; Fracture; Navigation; Pelvic; Sacral; Spinal; Traumatic
ID ILIOSACRAL SCREW INSERTION; ILIAC SCREWS; FIXATION; CLASSIFICATION;
   PLACEMENT; AOSPINE; INJURY; COMPLICATIONS; DEFORMITY; ACCURACY
AB BACKGROUND: Sacral fractures are a challenge regarding treatment and classification. Surgical techniques using spinal navigation systems can improve treatment, especially if used in collaboration among different specialists.
   METHODS: Between 2015 and 2017, we treated 25 consecutive cases of sacral fracture. Twelve patients (48%) underwent mechanical ventilation due to hypovolemic shock for severe thoracoabdominal trauma; bleeding was blocked with pelvic packing in 9 cases (36%) and trans-catheter embolization in 2 cases (8%). External fixation was used in 7 cases (28%). In 20 cases (80%) spinal fractures were associated. All patients were operated on using spinal navigation by a team of neurosurgeons and ortho-pedic surgeons.
   RESULTS: The mean time from first observation to surgery was 18 days (range 8-31). Surgical treatment consisted of iliosacral fixation in 19 cases (76%) and spinopelvic fixation in 6 cases (24%). The mean number of screws for spinopelvic fixation was 9.67 (range 6-17) with a mean operation time of 323.67 minutes (range 247-471); in iliosacral osteosynthesis the mean screw number was 1.37 (range 1-3) and mean surgical time was 78.93 minutes (range 61-130). Postoperative computed tomography showed the correct screw placement. Wound infection occurred in 2 cases (8%), managed with vacuum-assisted closure therapy; in 1 case (4%) a sacral screw was removed for decubitus.
   CONCLUSIONS: Navigation systems in instrumented spinopelvic and sacropelvic reconstruction provide greater safety, reducing learning times and malpositioning. Multi-disciplinary management allows us to achieve optimal results, especially when the sacral fracture is combined with spinal and pelvic lesions. The use of navigation systems could represent an important advancement.
C1 [Santoro, Giorgio; Gregori, Fabrizio; Santoro, Antonio; Domenicucci, Maurizio] Sapienza Univ Rome, UOD Emergency Orthopaed Traumatol, Dept Human Neurosci Neurosurg, Rome, Italy.
   [Braidotti, Piero] Sapienza Univ Rome, UOD Emergency Orthopaed Traumatol, Dept Emergency & Acceptance, Anesthesia & Crit Care Areas, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Gregori, F (通讯作者)，Sapienza Univ Rome, UOD Emergency Orthopaed Traumatol, Dept Human Neurosci Neurosurg, Rome, Italy.
EM fabr.gregori@gmail.com
OI Santoro, Giorgio/0000-0001-9392-3338
CR Akesen B, 2008, SPINE, V33, P1423, DOI 10.1097/BRS.0b013e3181753c04
   Blum L, 2018, INT ORTHOP, V42, P2663, DOI 10.1007/s00264-018-3883-1
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   Zheng ZM, 2009, SPINE, V34, pE565, DOI 10.1097/BRS.0b013e3181ac8fc4
   Ziran BH, 2007, J TRAUMA, V62, P347, DOI 10.1097/01.ta.0000229789.18211.85
   Zwingmann J, 2010, J TRAUMA, V69, P1501, DOI 10.1097/TA.0b013e3181d862db
   Zwingmann J, 2013, INJURY, V44, P1765, DOI 10.1016/j.injury.2013.08.008
   Zwingmann J, 2009, CLIN ORTHOP RELAT R, V467, P1833, DOI 10.1007/s11999-008-0632-6
NR 33
TC 7
Z9 14
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD NOV
PY 2019
VL 131
BP 399
EP 407
DI 10.1016/j.wneu.2019.07.050
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA JG3GV
UT WOS:000491963300171
PM 31658582
DA 2026-07-24
ER

PT J
AU Spindler, N
   Etz, CD
   Misfeld, M
   Josten, C
   Mohr, FW
   Langer, S
AF Spindler, Nick
   Etz, Christian D.
   Misfeld, Martin
   Josten, Christoph
   Mohr, Friedrich-Wilhelm
   Langer, Stefan
TI Omentum flap as a salvage procedure in deep sternal wound infection
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE deep sternal wound infection; omentum flap; reconstruction of the
   thorax; mediastinitis; DSWI
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; GREATER OMENTUM;
   CONVENTIONAL TREATMENT; CARDIAC-SURGERY; MUSCLE FLAPS; RISK-FACTORS;
   CHEST-WALL; STERNOTOMY; MANAGEMENT
AB Introduction: Deep sternal wound infections (DSWIs) are rare but devastating complication after median sternotomy following cardiac surgery. Especially in the presence of artificial material or inadequate preliminary muscle flaps, the pedicled omentum flap is due to its immunological properties, the predetermined flap in salvage procedures.
   Methods: We treated 14 patients suffering a mediastinitis and open thorax using a pedicled omentoplasty as a salvage procedure because of persisting DSWIs. Omentoplasty was performed in combination with a split skin graft and the wound was closed by a vacuum-assisted therapy for 7 days. The patients' sex and comorbid risk factors supporting DSWIs as well as the postoperative complications were recorded.
   Results: Retrospective analysis of 14 patients (10 males and four females) after a follow-up time of 24 months was performed. The average age was 75 years (range: 67-83). Heart surgery took place electively in eight cases, in three cases urgently and three for emergency reasons. The preoperative Euro Score was 16 (range 3.51-42.58). We had no flap loss in any patients. The skin graft showed a full take in all patients. Two patients needed revision of an abdominal wound dehiscence after laparotomy and one patient developed hernia in the late outcome.
   Discussion: The greater omentum flap has, over many years, become an ideal partner in the coverage and treatment of DSWIs. Especially due to its immunologic capacity and amorphous structure, it has the ability to fill up cavities and cover infected artificial material so residual infections can be controlled.
C1 [Spindler, Nick; Josten, Christoph; Langer, Stefan] Univ Hosp Leipzig, Dept Orthoped Surg Traumatol & Plast Surg, Liebigstr 20, D-04103 Leipzig, Germany.
   [Etz, Christian D.; Misfeld, Martin; Mohr, Friedrich-Wilhelm] Univ Leipzig, Leipzig Heart Ctr, Dept Cardiac Surg, Leipzig, Germany.
C3 Leipzig University; Heart Center Leipzig GMBH; Leipzig University
RP Spindler, N (通讯作者)，Univ Hosp Leipzig, Dept Orthoped Surg Traumatol & Plast Surg, Liebigstr 20, D-04103 Leipzig, Germany.
EM nick.spindler@medizin.uni-leipzig.de
OI Misfeld, Martin/0000-0001-7940-0629
CR Bender HW, 1997, ANN SURG, V225, P776
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NR 29
TC 28
Z9 36
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2017
VL 13
BP 1077
EP 1083
DI 10.2147/TCRM.S134869
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA FE5RG
UT WOS:000408268000003
PM 28883736
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Morinaga, K
   Kiyokawa, K
   Rikimaru, H
   Aoyagi, S
   Tayama, K
   Akashi, H
AF Morinaga, Keigo
   Kiyokawa, Kensuke
   Rikimaru, Hideaki
   Aoyagi, Shigeaki
   Tayama, Keiichiro
   Akashi, Hidetoshi
TI Results of intra-wound continuous negative pressure irrigation treatment
   for mediastinitis
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Mediastinitis; wound healing; wound closure; exposed heart and aorta;
   artificial dermis
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; POSTSTERNOTOMY
   MEDIASTINITIS; CARDIAC-SURGERY; INFECTION; EXPERIENCE; DRAINAGE;
   COMPLICATIONS; MANAGEMENT; MORTALITY
AB Intra-wound continuous negative pressure irrigation treatment (IW-CONPIT) was administered to cases of mediastinitis as the therapy of choice, with satisfactory results being obtained in terms of improved survival rates and quick healing of wounds. Accordingly, these treatment results and efficacy were evaluated. After debridement, a sponge was trimmed to conform to the shape of the wound and then it was attached to the surface of the wound. Two tubes with several side holes were placed within the sponge. In cases in which the blood vessels and/or the heart are exposed, an artificial dermis was attached to cover the blood vessels and/or the heart in order to not come in direct contact with the sponge. Next, the top of the wound was covered with polyethylene film to create an air-tight wound seal. A bottle of saline solution was connected to one of the tubes and a continuous aspirator to the other, and continuous negative pressure irrigation of the wound was thus carried out. After performing this treatment for 2-3 weeks, and when wound granulation improved, either skin grafts or the transplantation of muscle flaps was performed as necessary to achieve wound healing. A combination of the continuous negative pressure method and the continuous irrigation method resulted in improved healing rates and lower mortality rates for mediastinitis. It also significantly reduced the number of dressings, as well as the degree of labour and medical materials required; therefore, a reduced hospital stay and shorter treatment period was thus achieved using this treatment method.
C1 [Morinaga, Keigo; Kiyokawa, Kensuke; Rikimaru, Hideaki] Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg & Maxillofacial Sur, Kurume, Fukuoka 8300011, Japan.
   [Aoyagi, Shigeaki; Tayama, Keiichiro; Akashi, Hidetoshi] Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Morinaga, K (通讯作者)，Kurume Univ, Sch Med, Dept Plast & Reconstruct Surg & Maxillofacial Sur, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM prsmf@med.kurume-u.ac.jp
RI Kiyokawa, Kensuke/Q-5559-2017
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
   Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Bapat V, 2008, J CARDIAC SURG, V23, P227, DOI 10.1111/j.1540-8191.2008.00595.x
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NR 20
TC 9
Z9 11
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD SEP
PY 2013
VL 47
IS 4
BP 297
EP 302
DI 10.3109/2000656X.2013.765885
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 206AY
UT WOS:000323489200013
PM 23710790
OA gold
DA 2026-07-24
ER

PT J
AU Gib, MC
   Alvarez, JS
   Wender, OCB
AF Gib, Marcelo Curcio
   Alvarez, Juglans Souto
   Belmonte Wender, Orlando Carlos
TI Mediastinitis: mortality rate comparing single-stage surgical approach
   and preconditioning of wound
SO REVISTA BRASILEIRA DE CIRURGIA CARDIOVASCULAR
LA English
DT Article
DE Mediastinitis; Mortality; Infection; Surgical wound infection
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; RISK-FACTORS; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; MUSCLE FLAPS; MANAGEMENT;
   INFECTION; COMPLICATIONS; EXPERIENCE
AB Objective: This study aims to compare hospital mortality rate of surgical debridement followed by primary wound closure versus surgical debridement with closure after preconditioning of the wound.
   Methods: A historical cohort of 43 patients with postoperative mediastinitis type III and IV between 2000 and 2008. The diagnosis of mediastinitis was based on physical examination and laboratory tests. Patients were divided into two groups: patients who received the protocol of preconditioning of the wound (Group 2) and those who did not (Group 1).
   Results: Of the 43 patients, 15 received the protocol and were assigned to Group 2, and 28 patients to Group 1. Myocardial revascularisation was the surgical intervention most affected by infection, accounting for 69.8% of patients in Group 1 and 64.3% in Group 2. Staphylococcus aureus was the predominant pathogen, accounting for 58.1% of all cases, 50% in Group 1 and 73.3% in Group 2. Hospital mortality rate was 42.9% in Group 1 and 20% in Group 2 (P=1.86), with relative risk of 2.14 and CI [0.714-6.043]. Among the 28 (65.1%) patients who underwent single-stage surgical approach, 12 (27.9%) underwent primary wound closure with irrigation, seven (16.3%) only primary closure, six (14%) omental flap, and three (7%) pectoralis muscle flap.
   Conclusion: Due to the lack of established guidelines, the choice of the surgical approach is based largely on low-level evidence references. Preconditioning of the wound appears to lead to a reduction in mortality in these patients, being a good surgical option.
C1 [Gib, Marcelo Curcio; Alvarez, Juglans Souto] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Cardiovasc Surg, Porto Alegre, RS, Brazil.
   [Belmonte Wender, Orlando Carlos] Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul
RP Gib, MC (通讯作者)，Travessa Pedra Redonda, 450 Casa 9, BR-91760630 Porto Alegre, RS, Brazil.
EM mcgib@terra.com.br
FU FAPERGS e CAPES
FX FAPERGS e CAPES
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Berg HF, 2000, ANN THORAC SURG, V70, P924, DOI 10.1016/S0003-4975(00)01524-1
   Bilgin YM, 2004, CIRCULATION, V109, P2755, DOI 10.1161/01.CIR.0000130162.11925.21
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   Eklund AM, 2006, ANN THORAC SURG, V82, P1784, DOI 10.1016/j.athoracsur.2006.05.097
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   Jones G, 1997, ANN SURG, V225, P766, DOI 10.1097/00000658-199706000-00014
   JURKIEWICZ MJ, 1980, ANN SURG, V191, P738, DOI 10.1097/00000658-198006000-00012
   LEE AB, 1976, SURGERY, V80, P433
   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
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   SERRY C, 1980, J THORAC CARDIOV SUR, V80, P861
   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
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   YOMTOVIAN R, 1993, TRANSFUSION, V33, P902, DOI 10.1046/j.1537-2995.1993.331194082380.x
NR 25
TC 8
Z9 10
U1 0
U2 4
PU SOC BRASIL CIRURGIA CARDIOVASC
PI SAO PAULO SP
PA RUA AFONSO CELSO, 1178, SAO PAULO SP, 04119-061, BRAZIL
SN 0102-7638
EI 1678-9741
J9 REV BRAS CIR CARDIOV
JI Rev. Bras. Cir. Cardiovasc.
PY 2013
VL 28
IS 2
BP 200
EP 207
DI 10.5935/1678-9741.20130029
PG 8
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 187JE
UT WOS:000322112900008
PM 23939316
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Gannon, CJ
   Zager, JS
   Chang, GJ
   Feig, BW
   Wood, CG
   Skibber, JM
   Rodriguez-Bigas, MA
AF Gannon, Christopher J.
   Zager, Jonathan S.
   Chang, George J.
   Feig, Barry W.
   Wood, Christopher G.
   Skibber, John M.
   Rodriguez-Bigas, Miguel A.
TI Pelvic exenteration affords safe and durable treatment for locally
   advanced rectal carcinoma
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article; Proceedings Paper
CT 59th Annual Cancer Symposium of the Society-of-Surgical-Oncology
CY MAR 23-26, 2006
CL San Diego, CA
SP Soc Surg Oncol
DE pelvic exenteration; rectal carcinoma; complication rate; pelvic
   recurrence
ID COMBINED-MODALITY THERAPY; VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE;
   COLORECTAL ADENOCARCINOMA; PERCUTANEOUS DRAINAGE; CURATIVE RESECTION;
   RADICAL RESECTION; CANCER; EXPERIENCE; MANAGEMENT
AB Background: Treatment of locally advanced rectal carcinoma (LARC) often involves exenterative surgery, which can be associated with high perioperative morbidity and mortality. To assist in patient selection for radical surgery, we sought to determine clinicopathologic factors influencing recurrence and disease-free survival (DFS) of LARC.
   Methods: Consecutive patients with LARC undergoing exenterative surgery were retrospectively identified in our institutional database. Factors evaluated included age, sex, primary versus recurrent tumors, neoadjuvant or adjuvant chemoradiotherapy, resection margin status, recurrence, time to recurrence, and survival. The primary outcome was DFS. Secondary outcomes were overall survival and perioperative morbidity.
   Results: A total of 72 patients were identified;, median age was 52 years, and median follow-up time was 30 months. The overall complication rate was 43%; rates were similar among the patients with primary (47%) or recurrent (37%) LARC. Primary or recurrent tumor status was the only factor significantly predictive of outcome after exenteration. Local recurrence rates were lower in the primary group (primary 22%, recurrent 52%, P = .05). A significant difference in 5-year DFS was found between primary and recurrent tumor (52% vs. 13%; P < .01). The median time to recurrence was longer in the patients with primary LARC (17 months vs. 8 months; P < .01).
   Conclusions: The complication rates for pelvic exenteration remain high, but the morbidity can typically be managed without a clinically important increase in hospitalization. In primary LARC, an aggressive surgical approach provides most patients 5-year DFS. Select patients with recurrent LARC will also benefit from pelvic exenteration.
C1 Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Unit 444, Houston, TX 77030 USA.
   Univ Texas, MD Anderson Canc Ctr, Dept Urol, Unit 1373, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center
RP Rodriguez-Bigas, MA (通讯作者)，Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Unit 444, 1515 Holcombe Blvd, Houston, TX 77030 USA.
EM mrodbig@mdanderson.org
CR Bedrosian I, 2004, J GASTROINTEST SURG, V8, P56, DOI 10.1016/j.gassur.2003.09.019
   Boyle KM, 2005, DIS COLON RECTUM, V48, P929, DOI 10.1007/s10350-004-0909-0
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   Yamada K, 2002, DIS COLON RECTUM, V45, P1078, DOI 10.1007/s10350-004-6363-1
NR 28
TC 75
Z9 82
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD JUN
PY 2007
VL 14
IS 6
BP 1870
EP 1877
DI 10.1245/s10434-007-9385-9
PG 8
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Oncology; Surgery
GA 181XS
UT WOS:000247470300013
PM 17406945
DA 2026-07-24
ER

PT J
AU Evans, D
   Land, L
AF Evans, D
   Land, L
TI Topical negative pressure for treating chronic wounds: a systematic
   review
SO BRITISH JOURNAL OF PLASTIC SURGERY
LA English
DT Review
DE topical negative pressure; chronic wound; healing; randomised controlled
   trial
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB Some wounds take a long time to heal, fail to heal or recur, causing significant pain and discomfort to the patient and cost to the National Health Service. This review assesses the effectiveness of topical negative pressure (TNP) in treating chronic wounds. The Cochrane Wounds Group Specialised Trials Register was searched for randomised controlled trials (RCTs) that evaluated the effectiveness of TNP on chronic-wound healing. Eligibility for inclusion, data extraction and details of trial quality were conducted by two reviewers independently. A narrative synthesis of results was undertaken as only two small trials, with different outcome measures, fulfilled the selection criteria. Trial 1 considered any type of chronic wound, trial 2 considered diabetic foot ulcers. Both trials compared TNP with saline-gauze dressings. Trial 1 reported a statistically significant difference in the percentage change in wound volume after 6 weeks, in favour of TNP. Trial 2 reported a difference in the number of days to healing and a difference in the percentage change in wound surface area after 2 weeks, in favour of TNP. These two small trials provide weak evidence to suggest that TNP may be superior to saline-gauze dressings in terms of wound healing. However, due to the small sample sizes and the methodological limitations of the studies, these findings must be interpreted with extreme caution. The effects of TNP on cost, quality of life, pain and comfort were not reported. It was not possible to determine the optimum TNP regimen. Further high-quality RCTs that address these issues are required. (C) 2001 The British Association of Plastic Surgeons.
C1 Univ Cent England, Hlth & Social Care Res Ctr, Birmingham B15 3TN, W Midlands, England.
C3 Birmingham City University
RP Evans, D (通讯作者)，Univ Cent England, Hlth & Social Care Res Ctr, Ravensbury House,Westbourne Rd, Birmingham B15 3TN, W Midlands, England.
OI Land, Lucy/0000-0001-8634-8056
CR [Anonymous], WOUND REPAIR REGENER
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   1999, TECHNOLOGY ASSESSMEN
NR 30
TC 72
Z9 81
U1 1
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0007-1226
J9 BRIT J PLAST SURG
JI Br. J. Plast. Surg.
PD APR
PY 2001
VL 54
IS 3
BP 238
EP 242
DI 10.1054/bjps.2001.3547
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 419KE
UT WOS:000167947200013
PM 11254418
OA Bronze
DA 2026-07-24
ER

PT J
AU Bürlukkara, S
   Baran, Ö
AF Burlukkara, Salih
   Baran, Ozer
TI The Relationship between Procalcitonin, Systemic Inflammatory Index, and
   C-Reactive Protein and Skin Reconstruction in Fournier's Gangrene
   Patients: A Retrospective Single-Center Study
SO UROLOGIA INTERNATIONALIS
LA English
DT Article
DE Procalcitonin; Systemic inflammatory index; Fournier gangrene;
   Reconstruction
ID VACUUM-ASSISTED CLOSURE; OUTCOME PREDICTION; HYPERBARIC-OXYGEN;
   LYMPHOCYTE RATIO; SCORING SYSTEMS; MORTALITY; MANAGEMENT; THERAPY
AB Introduction: The aim of the study was to examine the relationship between skin reconstruction and systemic inflammatory index (SII), procalcitonin in Fournier's gangrene. Methods: Forty-seven male patients who underwent debridement and were diagnosed with Fournier's gangrene were included in this retrospective study. The patient groups were divided into two groups. Group 1 included 26 patients who required primary skin closure, and Group 2 included 21 patients who required skin grafts and flaps. Data regarding initial symptoms, physical examination findings, vital signs, and laboratory tests were collected through archive scanning. Patients with available data for the Fournier's gangrene severity index (FGSI), Uludag's Fournier's gangrene severity index (UFGSI), procalcitonin, C-reactive protein (CRP), and SII calculations were included in the study. Results: A significant difference in vital signs was found between the groups. Fever, pulse and respiratory rate were significantly greater in Group 2 than in Group 1 (p = 0.747). There was no significant difference in body mass index (BMI) or duration of hospitalization (p = 0.983). The average procalcitonin level of the patients measured preoperatively was 1.01 in Group 1 and 2.30 in Group 2. In Group 1, the average CRP level was 111.90, the SII was 3,460.00; in Group 2, the CRP level was 165.00, the SII was 6,544.00, and this difference between the two groups was significant (p = 0.011-0.018). Conclusion: CRP, procalcitonin, and SII rates can be measured simply, easily applied, and can provide insight into predicting skin reconstruction. (c) 2025 S. Karger AG, Basel
C1 [Burlukkara, Salih; Baran, Ozer] Karabuk Training & Res Hosp, Dept Urol, TC Minist Hlth, Karabuk, Turkiye.
C3 Ministry of Health - Turkey
RP Bürlukkara, S (通讯作者)，Karabuk Training & Res Hosp, Dept Urol, TC Minist Hlth, Karabuk, Turkiye.
EM salihburlukkara@karabuk.edu.tr
RI BÜRLUKKARA, SALİH/KHU-2061-2024
OI BÜRLUKKARA, SALİH/0000-0002-2149-0163
CR Carvalho Joao P., 2007, Int. braz j urol., V33, P510
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NR 31
TC 0
Z9 0
U1 1
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PD AUG
PY 2025
VL 109
IS 4
BP 391
EP 398
DI 10.1159/000545013
EA MAR 2025
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 5ZK4Y
UT WOS:001547988400001
PM 40049154
DA 2026-07-24
ER

PT J
AU Sapino, G
   Lanz, L
   Roesti, A
   Guillier, D
   Deglise, S
   De Santis, G
   Raffoul, W
   di Summa, P
AF Sapino, Gianluca
   Lanz, Loise
   Roesti, Aurore
   Guillier, David
   Deglise, Sebastien
   De Santis, Giorgio
   Raffoul, Wassim
   di Summa, Pietro
TI One-Stage Coverage of Leg Region Defects with STSG Combined with VAC
   Dressing Improves Early Patient Mobilisation and Graft Take: A
   Comparative Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE wound healing; leg ulcer; skin graft; vac therapy
ID THICKNESS SKIN-GRAFT; ASSISTED CLOSURE DEVICE; PRESSURE WOUND THERAPY;
   MANAGEMENT; FOOT
AB Lower limb skin defects are very common and can result from a wide range of aetiologies. Split thickness skin graft (STSG) is a widely used method to address these problems. The role of postoperative dressing is primary as it permits one to apply a uniform pressure over the grafted area and promote adherence. Focusing on lower limb reconstruction, our clinical study compares the application of V.A.C. (Vacuum Assisted Closure) Therapy vs. conventional dressing in the immediate postoperative period following skin grafting. We included in the study all patients who received skin grafts on the leg region between January 2015 and December 2018, despite the aetiology of the defect. Only reconstructions with complete preoperative and postoperative follow-up data were included in the study. Patients were divided into two groups depending on if they received a traditional compressive dressing or a VAC dressing in the immediate postoperative period. We could retain 92 patients, 23 in the No VAC group and 69 in the VAC group. The patients included in the VAC group showed a statistically significant higher rate of graft take together with a lower immobilisation time (p < 0.05). Moreover, a lower rate of postoperative infection was recorded in the VAC group. This study represents the largest in the literature to report in detail surgical outcomes comparing the use of VAC therapy vs. conventional dressing after STSG in the postoperative management of lower limb reconstruction using skin grafts. VAC therapy was used to secure the grafts in the leg region, increasing the early graft take rate while at the same time improving patient mobilisation.
C1 [Sapino, Gianluca; Lanz, Loise; Raffoul, Wassim; di Summa, Pietro] Ctr Hosp Univ Vaudois CHUV, Dept Plast & Hand Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Roesti, Aurore; Deglise, Sebastien] Ctr Hosp Univ Vaudois CHUV, Dept Vasc Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Guillier, David] Univ Hosp, Dept Plast Reconstruct & Hand Surg, Dept Oral & Maxillofacial Surg, Blvd Lattre de Tassigny, F-21000 Dijon, France.
   [De Santis, Giorgio] Univ Hosp Modena, Dept Plast & Reconstruct Surg, Largo Pozzo 71, I-41100 Modena, Italy.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Universite Bourgogne Europe; CHU Dijon Bourgogne; Universita di Modena e
   Reggio Emilia; Universita di Modena e Reggio Emilia Hospital
RP di Summa, P (通讯作者)，Ctr Hosp Univ Vaudois CHUV, Dept Plast & Hand Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM gianluca.sapino@chuv.ch; loiselanz@unil.ch; aurore.roesti@chuv.ch;
   docteurguillierdavid@gmail.com; sebastien.deglise@chuv.ch;
   desantis.giorgio@unimore.it; wassim.raffoul@chuv.ch;
   pietro.disumma@gmail.com
RI ; De Santis, Giorgio/P-9027-2016
OI Deglise, Sebastien/0000-0001-8244-952X; raffoul,
   wassim/0000-0002-3524-0077
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
   Blume PA, 2010, INT WOUND J, V7, P480, DOI 10.1111/j.1742-481X.2010.00728.x
   Carson Stanley N, 2004, Ostomy Wound Manage, V50, P52
   Ellis Georgina, 2016, Nurs Stand, V30, P36, DOI [10.7748/ns.30.27.36.s44, 10.7748/ns.30.27.36.s44]
   Fuller DA, 2016, J ORTHOP TRAUMA, V30, pS34, DOI 10.1097/BOT.0000000000000605
   Guillier D, 2021, INJURY, V52, P3117, DOI 10.1016/j.injury.2021.04.003
   Janowska A, 2019, CLIN INTERV AGING, V14, P2137, DOI 10.2147/CIA.S231896
   Kanakaris NK, 2007, INJURY, V38, pS9, DOI 10.1016/j.injury.2007.10.029
   Khan AA, 2020, CLIN PODIATR MED SUR, V37, P821, DOI 10.1016/j.cpm.2020.07.007
   Körber A, 2008, DERMATOLOGY, V216, P250, DOI 10.1159/000112937
   Maruccia M, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/8395219
   Meloni M, 2015, WORLD J ORTHOP, V6, P387, DOI 10.5312/wjo.v6.i4.387
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Ogawa Rei, 2007, Journal of Nippon Medical School, V74, P386, DOI 10.1272/jnms.74.386
   Pappalardo Vincenzo, 2019, SURG TECHNOL INT, V34
   Putnis Sven, 2014, Open Orthop J, V8, P142, DOI 10.2174/1874325001408010142
   Reeder S, 2013, BRIT J DERMATOL, V168, P999, DOI 10.1111/bjd.12164
   Retrouvey H, 2018, J BURN CARE RES, V39, P902, DOI 10.1093/jbcr/iry003
   Ross RE, 2011, J WOUND CARE, V20, P490, DOI 10.12968/jowc.2011.20.10.490
   Sapino G, 2019, J PLAST RECONSTR AES, V72, P467, DOI 10.1016/j.bjps.2018.11.002
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer LA, 2002, ARCH SURG-CHICAGO, V137, P930, DOI 10.1001/archsurg.137.8.930
   Schneider C, 2021, MED CLIN N AM, V105, P663, DOI 10.1016/j.mcna.2021.04.006
   Sposato G, 2001, BRIT J PLAST SURG, V54, P235, DOI 10.1054/bjps.2000.3537
NR 24
TC 13
Z9 15
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2022
VL 11
IS 12
AR 3305
DI 10.3390/jcm11123305
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2M1SR
UT WOS:000817488800001
PM 35743375
OA Green Submitted, Green Published, gold
DA 2026-07-24
ER

PT J
AU Wübbeke, LF
   Conings, JZM
   Elshof, JW
   Scheltinga, MR
   Daemen, JWHC
   Jacobs, MJ
   Mees, BM
AF Wuebbeke, Lina F.
   Conings, Jurek Z. M.
   Elshof, Jan-Willem
   Scheltinga, Marc R.
   Daemen, Jan-Willem H. C.
   Jacobs, Michael J.
   Mees, Barend M.
TI Outcome of rectus femoris muscle flaps for groin coverage after vascular
   surgery
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Surgical wound infection; Vascular prosthesis infection; Groin wound
   reconstruction; Rectus femoris muscle flap; Sartorius muscle flap
ID VACUUM-ASSISTED CLOSURE; DONOR-SITE MORBIDITY; GRAFT INFECTION;
   MANAGEMENT; SARTORIUS; THERAPY; WOUNDS; BYPASS
AB Objective: The aim of this retrospective cohort study was to investigate the outcome of rectus femoris muscle flaps (RFFs) for deep groin wound complications in vascular surgery patients and to compare the outcome with a cohort of sartorius muscle flaps (SMFs) because the RFF is a promising alternative technique for groin coverage.
   Methods: All RFFs and SMFs performed by vascular surgeons in a regional collaboration in The Southern Netherlands were retrospectively reviewed. Primary outcomes were muscle flap survival, overall and secondary graft salvage, and limb salvage. Secondary outcomes were 30-day groin wound complications and mortality, donor site and vascular complications, 1-year amputation-free survival, overall patient survival, impaired knee extensor function, and length of hospital stay.
   Results: A total of 96 RFFs were performed in 88 patients (mean age, 68 years; 67% male) and compared with a cohort of 30 SMFs in 28 patients (mean age, 64 years; 77% male). At a mean follow-up of 29 months and 23 months, respectively, comparable flap survival (94% vs 90%), secondary graft salvage (80% vs 92%), and limb salvage (89% vs 90%) rates were found. The 30-day mortality rates were 12% and 17%, respectively, and the 1-year amputation-free survival was comparable between treatment groups (71% vs 68%).
   Conclusions: This study presents a large series of RFFs for deep groin wound complications after vascular surgery. We demonstrate that muscle flap coverage using the rectus femoris muscle by vascular surgeons is an effective way to manage complex groin wound infections in a challenging group of patients, achieving similarly good results as the SMF.
C1 [Wuebbeke, Lina F.; Conings, Jurek Z. M.; Daemen, Jan-Willem H. C.; Jacobs, Michael J.; Mees, Barend M.] Maastricht Univ, Med Ctr, Dept Vasc Surg, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
   [Elshof, Jan-Willem] VieCuri Hosp, Dept Surg, Venlo, Netherlands.
   [Scheltinga, Marc R.] Maxima Med Ctr, Dept Surg, Veldhoven, Netherlands.
   [Jacobs, Michael J.; Mees, Barend M.] European Vasc Ctr Aachen Maastricht, Aachen, Germany.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   VieCuri Medical Center; Maxima Medical Center; Maastricht University
RP Mees, BM (通讯作者)，Maastricht Univ, Med Ctr, Dept Vasc Surg, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
EM barend.mees@mumc.nl
OI Mees, Barend/0000-0001-6545-5813
CR Alkon JD, 2005, PLAST RECONSTR SURG, V115, P776, DOI 10.1097/01.PRS.0000152436.50604.04
   Chang JK, 2003, ANN VASC SURG, V17, P91, DOI 10.1007/s10016-001-0337-8
   Colwell AS, 2004, ANN PLAS SURG, V52, P49, DOI 10.1097/01.sap.0000099960.68038.53
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NR 27
TC 15
Z9 15
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
EI 1097-6809
J9 J VASC SURG
JI J. Vasc. Surg.
PD SEP
PY 2020
VL 72
IS 3
BP 1050
EP +
DI 10.1016/j.jvs.2019.11.031
PG 10
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA NU9OZ
UT WOS:000573966400036
PM 32122734
OA Green Published, Bronze
DA 2026-07-24
ER

PT J
AU Fiori, F
   Ferrara, F
   Gobatti, D
   Gentile, D
   Stella, M
AF Fiori, Federico
   Ferrara, Francesco
   Gobatti, Davide
   Gentile, Daniele
   Stella, Marco
TI Surgical treatment of diastasis recti: the importance of an overall view
   of the problem
SO HERNIA
LA English
DT Article
DE Diastasis recti; Surgery; Minimally invasive; Abdominal wall; Hernia
ID BODY-MASS INDEX; WOUND COMPLICATIONS; MUSCLE DIASTASIS; VENTRAL HERNIA;
   RISK-FACTORS; MESH REPAIR; ABDOMINOPLASTY; SURGERY; PREVALENCE;
   ABDOMINIS
AB Purpose Diastasis recti (DR) is characterized by an alteration of the linea alba with increased inter-recti distance (IRD). It is more frequent in females, and when symptomatic or associated with midline hernia it needs to be surgically repaired. This retrospective study aims to demonstrate how an overall approach to DR leads to good results in terms of functional and morphological outcomes and quality of life (QoL). Methods From January 2018 to December 2019, 94 patients were operated for DR > 50 mm, with or without midline hernias. Three different surgical approaches were used: complete laparoabdominoplasty, laparominiabdominoplasty and minimally invasive (endoscopic) technique. QoL was assessed with the EuraHS-QoL tool. Results All patients were female except two males. We performed 26 endoscopic treatments (27.7%), 39 laparoabdominoplasties (41.5%) and 29 laparominiabdominoplasties (umbilical float procedure) (30.9%). The total median operative time was 160 min. No intraoperative complications were registered. In three (4.2%) cases, major surgical complications occurred, all after open operations. In 13 open surgery cases, vacuum-assisted closure (VAC) therapy was used to repair the cutaneous ischemic defect. No recurrence was registered to date. Minimally invasive surgery showed fewer complications and lower hospital stay than the open approach. The QoL was significantly improved. Conclusion Our experience shows the importance of an overall view of the functional and cosmetic impairment created by DR. The surgeon should obtain an optimal repair of the function, by open or minimally invasive surgery, also considering the morphological aspects, which are very important for the patients in terms of QoL.
C1 [Fiori, Federico; Ferrara, Francesco; Gobatti, Davide; Gentile, Daniele; Stella, Marco] San Carlo Borromeo Hosp, Unit Gen Surg, Dept Surg, ASST Santi Paolo & Carlo, Via Pio II 3, I-20153 Milan, Italy.
C3 San Carlo Borromeo Hospital
RP Ferrara, F (通讯作者)，San Carlo Borromeo Hosp, Unit Gen Surg, Dept Surg, ASST Santi Paolo & Carlo, Via Pio II 3, I-20153 Milan, Italy.
EM frr.fra@gmail.com
RI ; Ferrara, Francesco/A-4559-2014; Ferrara, Francesco/A-4559-2014
OI Gobatti, Davide/0000-0002-1674-5168; Ferrara,
   Francesco/0000-0002-8208-1945; Ferrara, Francesco/0000-0001-9298-6783
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NR 57
TC 27
Z9 31
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD AUG
PY 2021
VL 25
IS 4
BP 871
EP 882
DI 10.1007/s10029-020-02252-0
EA JUN 2020
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UC6MV
UT WOS:000546167300001
PM 32564225
DA 2026-07-24
ER

PT J
AU van der Slegt, J
   Kluytmans, JAJW
   de Groot, HGW
   van der Laan, L
AF van der Slegt, Jasper
   Kluytmans, Jan A. J. W.
   de Groot, Hans G. W.
   van der Laan, Lijckle
TI Treatment of surgical site infections (SSI) IN patients with peripheral
   arterial disease: An observational study
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Surgical site infection; Vascular surgery; Treatment
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; PROSTHETIC GRAFT
   INFECTIONS; VASCULAR-SURGERY; WOUND INFECTIONS; GROIN; EXPERIENCE;
   MANAGEMENT; THERAPY; BYPASS
AB Introduction: The management of surgical site infections (SSI's) in vascular surgery has been challenging over the years. To assess the outcomes associated with the various strategies, we performed a review of all SSI's after elective vascular procedures in patients with moderate to severe peripheral arterial disease in a single centre hospital.
   Methods: All patients with a SSI after peripheral vascular surgery were retrieved from a database on Surgical site infections (SSI)-surveillance after vascular surgery between March 2009 and January 2012. At admission, all patients were approached by microbiological wound sampling and empirical start of antibiotics. Further wound management was based on personal experience and preference of the attending vascular surgeon. Endpoints were treatment success (complete wound healing while staying alive and without major amputation), survival and major amputation during one year follow up.
   Results: A total of 40 patients with a SSI were identified (60% superficial SSI and 40% deep SSI). In 92% of the patients with a superficial SSI's were successfully treated with adjusted antibiotics and incisional drainages. In the contrast, 25% of the patients with deep-SSI's were successfully treated. No particular treatment was more successful than the others.
   Conclusion: Adjusted antibiotic use and adequate wound drainage are sufficient strategies for superficial SSI management. The management of deep-SSI's is a challenging undertaking and future research on indications and timing of these wide arrays of treatment options is suggested. (C) 2015 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [van der Slegt, Jasper; de Groot, Hans G. W.; van der Laan, Lijckle] Amphia Hosp, Dept Surg, NL-4800 RK Breda, Netherlands.
   [Kluytmans, Jan A. J. W.] Amphia Hosp, Lab Microbiol & Infect Control, NL-4800 RK Breda, Netherlands.
   [Kluytmans, Jan A. J. W.] Vrije Univ Amsterdam, Med Ctr, Dept Med Microbiol & Infect Control, Amsterdam, Netherlands.
C3 Amphia Hospital; Amphia Hospital; Vrije Universiteit Amsterdam
RP van der Slegt, J (通讯作者)，Amphia Hosp, Dept Surg, POB 90158, NL-4800 RK Breda, Netherlands.
EM JvanderSlegt@amphia.nl
OI van der laan, lijckle/0000-0001-5631-594X
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NR 22
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD FEB
PY 2015
VL 14
BP 85
EP 89
DI 10.1016/j.ijsu.2015.01.011
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB6SK
UT WOS:000349756700016
PM 25612852
DA 2026-07-24
ER

PT J
AU Khanlari, B
   Elzi, L
   Estermann, L
   Weisser, M
   Brett, W
   Grapow, M
   Battegay, M
   Widmer, AF
   Flückiger, U
AF Khanlari, Bettina
   Elzi, Luigia
   Estermann, Laura
   Weisser, Maja
   Brett, Wolfgang
   Grapow, Martin
   Battegay, Manuel
   Widmer, Andreas F.
   Flueckiger, Ursula
TI A rifampicin-containing antibiotic treatment improves outcome of
   staphylococcal deep sternal wound infections
SO JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
LA English
DT Article
DE surgical site infections; sternotomy; cardiac surgery; management;
   rifampicin
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; CARDIAC-SURGERY;
   RISK-FACTORS; POSTSTERNOTOMY MEDIASTINITIS; COMPLICATIONS; ENDOCARDITIS;
   THERAPY; MICROBIOLOGY; STERNOTOMY
AB Deep sternal wound infection (DSWI) is a severe complication after cardiac surgery, mostly caused by staphylococci. Little is known about the optimal antibiotic management.
   A 10 year retrospective analysis of 100 patients with staphylococcal DSWI after cardiac surgery in a tertiary hospital. Treatment failure was defined as sternal wound dehiscence or fistula at the end of the prescribed antibiotic therapy, 12 months later, or DSWI-related death.
   Most patients were male (83%) and the median age was 72 years [interquartile range (IQR) 63-76]. Coronary artery bypass was the most frequent preceding procedure (93%). The median time to diagnosis of DSWI was 13 days (IQR 10-18) after surgery. Clinical presentation consisted of wound discharge in 77% of patients. Coagulase-negative staphylococci were isolated in 54 and Staphylococcus aureus in 46 patients. All patients received antibiotics and 95% underwent surgical debridement. The median duration of antibiotic treatment was 47 days (IQR 41-78). During follow-up, 21 out of 100 patients experienced treatment failure. Of these, 8/21 patients (38%) died from DSWI after a median of 12 days (IQR 8-30). In the multivariate analysis, a rifampicin-containing antibiotic regimen was the only factor associated with lower risk of treatment failure (hazard ratio 0.26, 95% confidence interval 0.10-0.64, P = 0.004). Prolonged treatment (12 weeks instead of 6 weeks) did not alter outcome (P = 0.716) in patients without prosthetic valve endocarditis.
   Treatment of rifampicin-susceptible staphylococcal DSWI with a rifampicin-containing antibiotic regimen may improve the outcome. After surgical debridement an antibiotic treatment of 6 weeks may be adequate for staphylococcal DSWI.
C1 [Khanlari, Bettina; Elzi, Luigia; Estermann, Laura; Weisser, Maja; Battegay, Manuel; Widmer, Andreas F.; Flueckiger, Ursula] Univ Basel Hosp, Div Infect Dis & Hosp Epidemiol, CH-4031 Basel, Switzerland.
   [Brett, Wolfgang; Grapow, Martin] Univ Basel Hosp, Dept Cardiovasc Surg, CH-4031 Basel, Switzerland.
C3 University of Basel; University of Basel
RP Flückiger, U (通讯作者)，Univ Basel Hosp, Div Infect Dis & Hosp Epidemiol, CH-4031 Basel, Switzerland.
EM uflueckiger@uhbs.ch
OI Elzi, Luigia/0009-0002-7676-8756; Weisser, Maja/0000-0002-0134-1929;
   Grapow, Martin/0000-0001-6316-0691
FU Department of Internal Medicine, University Hospital Basel; Stiftung
   Forschung Infektionskrankheiten, Basel
FX This study has been supported by unrestricted grants of the Department
   of Internal Medicine, University Hospital Basel (L. E.) and the Stiftung
   Forschung Infektionskrankheiten, Basel (B. K. and U. F.).
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NR 42
TC 30
Z9 33
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-7453
EI 1460-2091
J9 J ANTIMICROB CHEMOTH
JI J. Antimicrob. Chemother.
PD AUG
PY 2010
VL 65
IS 8
BP 1799
EP 1806
DI 10.1093/jac/dkq182
PG 8
WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy
GA 627DD
UT WOS:000280018400039
PM 20542908
OA Bronze
DA 2026-07-24
ER

PT J
AU Armenio, A
   Cutrignelli, DA
   Nardulli, ML
   Maggio, G
   Memeo, G
   De Santis, V
   Giudice, G
   Ressa, CM
AF Armenio, Andrea
   Cutrignelli, Daniela Anna
   Nardulli, Maria Luisa
   Maggio, Giulio
   Memeo, Giuseppe
   De Santis, Valerio
   Giudice, Giuseppe
   Ressa, Cosmo Maurizio
TI Bio-Engineering tissue and VAC therapy: A new method for the treatment
   of extensive necrotizing infection in the diabetic foot
SO ANNALI ITALIANI DI CHIRURGIA
LA English
DT Article
DE Bio-Engineered Tissue; Diabetic foot; Fibroblast graft; VAC therapy
ID RANDOMIZED CONTROLLED-TRIAL; ASSISTED CLOSURE; CLINICAL-TRIAL; ULCERS;
   MULTICENTER; DERMAGRAFT; MANAGEMENT; EFFICACY; WOUNDS; STATE
AB AIM: The aim of the study is to compare the standard care for progressive necrotizing infection in diabetic foot with a treatment protocol based on the association between autologous fibroblast grafts and vacuum-assisted closure therapy (VAC).
   MATERIAL OF STUDY: A retrospective matched Case-Control study was carried out on 20 patients with diabetic foot infection, 10 treated with the standard care and 10 with our new protocol. Inclusion criteria were: acute diabetic foot necrosis (Wagner III and TO, ulcer size (30 to 80 cm2), tendon and bone exposure. Success in the treatment was evaluated as: percentage of healing at the 20th week, time of healing, deambulation, recurrence and major amputation rate.
   RESULTS: A 90% healing rate was observed after 20 weeks in the study group, compared to a 28.6% in the control group. The recurrence rate in the treated areas was 20% in the study group and 100% in the control group. None of the patients in either group required major amputations.
   DISCUSSION: We achieved very promising results by associating autologous fibroblasts grafts and V.A.C. therapy, in comparison with standard care. V.A.C. therapy seems to improve the growth rate of the fibroblasts, probably by sealing the wound and providing a moist environment following the fibroblast graft. The improved neoangiogenesis of the neo-dermis could explain the reduced recurrence rate of the study group.
   CONCLUSIONS: Despite the low number of patients involved and the retrospective nature of the analysis, this study showed a reliable, safe and cost-effective method of treating extensive infection in the diabetic foot.
C1 [Armenio, Andrea; Cutrignelli, Daniela Anna; Nardulli, Maria Luisa; De Santis, Valerio; Ressa, Cosmo Maurizio] Natl Canc Inst Giovanni Paolo II, Dept Plast & Reconstruct Surg, Viale Orazio Flacco 65, I-70124 Bari, Italy.
   [Maggio, Giulio; Memeo, Giuseppe; Giudice, Giuseppe] Univ Hosp Policlin, Dept Plast & Reconstruct Surg, Bari, Italy.
C3 IRCCS Istituto Tumori Bari Giovanni Paolo II; Universita degli Studi di
   Bari Aldo Moro
RP Cutrignelli, DA (通讯作者)，Natl Canc Inst Giovanni Paolo II, Dept Plast & Reconstruct Surg, Viale Orazio Flacco 65, I-70124 Bari, Italy.
EM daniela.cutrignelli@gmail.com
RI armenio, anea/AAI-3261-2020; /AAJ-8291-2020; Cutrignelli,
   Daniela/AAJ-8214-2020; ressa, cosmo/AAI-2285-2020
OI armenio, anea/0000-0002-7224-5176; Memeo, Giuseppe/0009-0008-6183-6684; 
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NR 25
TC 6
Z9 6
U1 0
U2 9
PU EDIZIONI LUIGI POZZI
PI ROME
PA VIA PANAMA 68, 00198 ROME, ITALY
SN 0003-469X
EI 2239-253X
J9 ANN ITAL CHIR
JI Ann. Ital. Chir.
PD MAY-JUN
PY 2017
VL 88
IS 3
BP 268
EP 274
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FG6EH
UT WOS:000410463400017
PM 28098565
DA 2026-07-24
ER

PT J
AU Rubayi, S
   Chandrasekhar, BS
AF Rubayi, Salah
   Chandrasekhar, Bala S.
TI Trunk, Abdomen, and Pressure Sore Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID ABDOMINAL-WALL DEFECTS; VACUUM-ASSISTED CLOSURE; GLUTEUS MAXIMUS MUSCLE;
   PERFORATOR-BASED FLAP; MYOCUTANEOUS FLAP; MUSCULOCUTANEOUS FLAP;
   PLASTIC-SURGERY; OMENTAL FLAP; ISLAND FLAP; THIGH FLAP
AB Chest wall reconstruction is indicated following tumor resection, radiation wound breakdown, or intrathoracic sepsis. Principles of wound closure and chest wall stabilization, where indicated, are discussed. Principles of abdominal wall reconstruction continue to evolve with the introduction of newer bioprosthetics and the application of functional concepts for wound closure. The authors illustrate these principles using commonly encountered clinical scenarios and guidelines to achieve predictable results. Pressure ulcers continue to be devastating complications to patients' health and a functional hazard when they occur in the bedridden, in patients with spinal cord injuries, and in patients with neuromuscular disease. Management of pressure ulcers is also very expensive. The authors describe standard options to treat defects of the chest, abdomen, and back and pressure ulcers in all anatomical areas. A comprehensive understanding of principles and techniques will allow practitioners to approach difficult issues of torso reconstruction and pressure sores with a rational confidence and an expectation of generally satisfactory outcomes. With pressure ulcers, prevention remains the primary goal. Patient education and compliance coupled with a multidisciplinary team approach can reduce their occurrence significantly. Surgical management includes appropriate patient selection, adequate debridement, soft-tissue coverage, and use of flaps that will not limit future reconstructions if needed. Postoperatively, a strict protocol should be adapted to ensure the success of the flap procedure. Several myocutaneous flaps commonly used for the surgical management of pressure are discussed. Commonly used flaps in chest and abdominal wall reconstruction are discussed and these should be useful for the practicing plastic surgeon. (Plast. Reconstr. Surg. 128: 201e, 2011.)
C1 [Rubayi, Salah] Rancho Los Amigos Natl Rehabil Ctr, Dept Surg, Downey, CA 90242 USA.
   Univ So Calif, Keck Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA 90033 USA.
C3 University of Southern California
RP Rubayi, S (通讯作者)，Rancho Los Amigos Natl Rehabil Ctr, Dept Surg, 7601 E Imperial Highway, Downey, CA 90242 USA.
EM srubayi@dhs.lacounty.gov
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NR 77
TC 18
Z9 19
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2011
VL 128
IS 3
BP 201E
EP 215E
DI 10.1097/PRS.0b013e31822214c1
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 812JB
UT WOS:000294288100013
PM 21865994
DA 2026-07-24
ER

PT J
AU Avery, CME
AF Avery, C. M. E.
TI Review of the radial free flap: is it still evolving, or is it facing
   extinction? Part one: soft-tissue radial flap
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Review
DE Radial flap; Morbidity; Donor site; Fasciocutaneous; Septocutaneous;
   Skin graft; Negative pressure wound dressing
ID ANTEROLATERAL THIGH FLAP; FOREARM FREE-FLAP; DONOR-SITE MORBIDITY;
   FULL-THICKNESS SKIN; VACUUM-ASSISTED CLOSURE; MAJOR MYOCUTANEOUS FLAP;
   ARM FREE-FLAP; NECK RECONSTRUCTION; SUPRAFASCIAL DISSECTION;
   MAXILLOFACIAL RECONSTRUCTION
AB The versatile fasciocutaneous radial flap is robust and reliable, straightforward to harvest, and often produces a satisfactory reconstruction with relatively little long-term morbidity at the donor site. Many surgeons prefer to use a limited number of trusted flaps, and these qualities will ensure that in the intermediate future most surgical trainees will continue to be shown the fasciocutaneous radial flap as both the basic training flap and the established option for reconstruction. Evidence from observational clinical studies and one randomised clinical trial indicates that there is increasing support for the use of the evolutionary technique of suprafascial dissection to minimise morbidity at the donor site. The suprafascial donor site may be repaired with either a meshed or unmeshed partial-thickness skin graft, or a fenestrated full-thickness skin graft, with good rates of successful healing. The application of a negative pressure dressing to the wound seems to facilitate the healing of all types of skin graft. The subfascial donor site, however, remains more prone to complications. It may be helpful to position the donor site of the flap more proximally, but this has not been proven. These refinements probably produce the best outcomes that can currently be achieved. given the inherent Haws of the radial donor site. (C) 2009 The British Association of Oral and Maxillolacial Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Univ Hosp Leicester, Leicester LE1 5WW, Leics, England.
C3 University Hospitals of Leicester NHS Trust; University of Leicester
RP Avery, CME (通讯作者)，Univ Hosp Leicester, Leicester LE1 5WW, Leics, England.
EM chrisavery@doctors.org.uk
RI /AAI-1364-2019
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NR 122
TC 47
Z9 53
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
EI 1532-1940
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD JUN
PY 2010
VL 48
IS 4
BP 245
EP 252
DI 10.1016/j.bjoms.2009.09.004
PG 8
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 615HV
UT WOS:000279126300001
PM 19837491
DA 2026-07-24
ER

PT J
AU Ennker, IC
   Pietrowski, D
   Vöhringer, L
   Kojcici, B
   Albert, A
   Vogt, PM
   Ennker, J
AF Ennker, I. C.
   Pietrowski, D.
   Voehringer, L.
   Kojcici, B.
   Albert, A.
   Vogt, P. M.
   Ennker, J.
TI Surgical debridement, vacuum therapy and pectoralis plasty in
   poststernotomy mediastinitis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum therapy; M. pectoralis muscle flaps; Mediastinitis; Sternotomy;
   Infection
ID STERNAL WOUND-INFECTION; ASSISTED CLOSURE; MEDIAN STERNOTOMY;
   RADIAL-ARTERY; LONG-TERM; DEEP; COMPLICATIONS
AB In cardiac surgery poststernotomy mediastinitis continues to be a serious cause of morbidity and mortality. We report our experience with vacuum-assisted closure (VAC) therapy followed by reconstruction with M. pectoralis muscle flaps as treatment for deep sternal wound infections. Our group performed a retrospective analysis of 3630 consecutive cardiac surgical patients using median sternotomy from 11/2004 to 11/2007. After removing sternal wires, necrotic debris and potentially infective material, restabilisation of the sternum was performed and VAC therapy was employed. Wound closure and subsequent reconstruction were performed using a bilateral pectoralis muscle plasty. Of the analysed patients 16 female and 29 male patients suffered from deep sternal wound infections and were treated with VAC. The most common risk factors were diabetes mellitus odds ratio (OR 3.5), chronic obstructive pulmonary disease (COPD) (OR 2.9), use of bilateral mammarian artery (OR 2.0) and obesity (1.8). The median age of patients with deep sternal infections was similar to control patients. Staphylococcus epidermis was the most common pathogen (37.8%) followed by Enterococcus faecilis (22.2%) and Staphylococcus aureus (17.8). In 22.2% no pathogen could be detected. The 30 day mortality was 0%, the in-hospital mortality was 15.6%. The results of our studies demonstrate that vacuum therapy in conjunction with early and aggressive debridement is an effective strategy for treating poststernotomy mediastinitis. We consider pectoralis major muscle flap reconstruction as a safe technique and regard it as the primary choice for wound closure in poststernotomy mediastinitis. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Ennker, I. C.; Vogt, P. M.] Hannover Med Sch, Klin Plast Hand & Wiederherstellungschirurg, D-30625 Hannover, Germany.
   [Ennker, I. C.; Pietrowski, D.; Voehringer, L.; Kojcici, B.; Albert, A.; Ennker, J.] Herzzentrum Lahr Baden, D-77933 Lahr, Germany.
C3 Hannover Medical School
RP Ennker, IC (通讯作者)，Hannover Med Sch, Klin Plast Hand & Wiederherstellungschirurg, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM ennker.ina@mh-hannover.de
RI ; Vogt, Peter/AAL-1332-2020
OI Vöhringer, Luise/0009-0001-4741-2980; 
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NR 15
TC 35
Z9 39
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2009
VL 62
IS 11
BP 1479
EP 1483
DI 10.1016/j.bjps.2008.05.017
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536XW
UT WOS:000273078200022
PM 18996074
DA 2026-07-24
ER

PT J
AU Desbois, E
   Zagzoog, M
   Cameliere, L
   Berger, L
   Vautier, H
AF Desbois, Eva
   Zagzoog, Mohammad
   Cameliere, Lucie
   Berger, Ludovic
   Vautier, Hugues
TI Abandoning Routine Drainage in Common Femoral Artery Exposure: A
   Prospective Study of Wound Outcomes and the Impact ofObesity
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID SURGICAL SITE INFECTION; OCCLUSIVE DISEASE; ENDARTERECTOMY;
   COMPLICATIONS
AB Background: To prospectively evaluate the safety and clinical outcomes of a no-drain approach for common femoral artery (CFA) exposure, challenging the routine use of closed suction drainage. Methods: This single-center, prospective, observational study (December 2023-June 2025) enrolled consecutive patients undergoing CFA exposure using a strict no-drain protocol. The primary end point was 30-day major adverse events (mortality, rehospitalization, or surgical reintervention). Secondary end points included primary patency, graded wound complications at 14 and 30 days, and multivariate predictors of wound morbidity. Results: We analyzed 151 patients (median age 67; 78.1% male; 21.2% obese), with 67.5% undergoing hybrid procedures. The 30-day major adverse event rate was 8% (n= 12), and 3month primary patency was 97.4%. Early wound morbidity at 14 days included major dehiscence (16.5%) and superficial infection (10.6%), managed conservatively or with vacuum-assisted closure. Despite this early morbidity, major surgical reoperation for wound complications remained low at 2.6%. Multivariate analysis identified body mass index as the sole independent predictor of wound complications (adjusted odds ratio 1.14; 95% confidence interval 1.06-1.23; P< 0.001). Complication rates were similar between isolated CFA endarterectomy and hybrid procedures (21.4% vs 24.5%; P= 0.32). Conclusion: A no-drain approach for CFA exposure is feasible and yields a low rate of surgical reoperation, a profile that extends even to complex hybrid procedures. Although early local wound morbidity is notable and requires proactive management, it is primarily driven by patient phenotype, specifically obesity.
C1 [Desbois, Eva; Cameliere, Lucie; Berger, Ludovic; Vautier, Hugues] Caen Univ Hosp, Dept Vasc & Endovascular Surg, Caen, France.
   [Zagzoog, Mohammad] Grp Hosp Paris St Joseph Marie Lannelongue, Dept Vasc & Endovascular Surg, 133 Av Resistance, F-92350 Le Plessis Robinson, France.
   [Zagzoog, Mohammad] Sorbonne Univ, Fac Med, F-75005 Paris, France.
C3 CHU de Caen NORMANDIE; Universite de Caen Normandie; Universite Paris
   Cite; Sorbonne Universite
RP Zagzoog, M (通讯作者)，Grp Hosp Paris St Joseph Marie Lannelongue, Dept Vasc & Endovascular Surg, 133 Av Resistance, F-92350 Le Plessis Robinson, France.; Zagzoog, M (通讯作者)，Sorbonne Univ, Fac Med, F-75005 Paris, France.
EM Mohammadmzagzoog@gmail.com
RI Zagzoog, Mohammad/PNF-8280-2026
OI Zagzoog, Mohammad/0000-0002-4275-2839
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD AUG
PY 2026
VL 129
BP 422
EP 429
DI 10.1016/j.avsg.2026.04.023
EA MAY 2026
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA IC7YM
UT WOS:001768616800001
PM 42019721
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Egin, S
   Kamali, S
   Hot, S
   Gökcek, B
   Yesiltas, M
   Duman, MG
   Alemdar, A
AF Egin, Seracettin
   Kamali, Sedat
   Hot, Semih
   Gokcek, Berk
   Yesiltas, Metin
   Duman, Mehmet Guray
   Alemdar, Ali
TI The importance of the scoring system in Fournier's gangrene
SO ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA &
   EMERGENCY SURGERY
LA English
DT Article
DE Fournier's gangrene; Fournier's gangrene severity index; Uludag
   Fournier's gangrene severity index
ID SEVERITY INDEX; VALIDATION; MORTALITY
AB BACKGROUND: The objective of the study was to investigate risk factors affecting mortality rates in patients with Fournier's gangrene (FG) and develop methods to increase the survival rate.
   METHODS: We collected data of 73 patients treated for FG between February 2012 and June 2021 at Istanbul Professor Doctor Cemil Tascioglu City Hospital General Surgery Clinic. The data of living patients (Group 1, n=56) and deceased patients (Group 2, n=17) were analyzed separately. Demographic data of patients were sex, age, infection rate, Uludag FG severity index (UFGSI) scores and FG severity index (FGSI) scores, urea serum levels, the source of infection, the presence of diabetes, obesity, the presence of diversion stoma, duration of vacuum-assisted closure treatment in days, hospitalization time in days, intensive care period in days, and isolated bacterial species.
   RESULTS: The mortality rate was 23%. A significant difference in age and dissemination score of the infection was found between the two groups. According to UFGSI and FGSI scores, the scores of the two groups of patients were significantly higher. The UFGSI had 100% sensitivity and 68% sensitivity. FGSI had 82% sensitivity and 58% specificity. The cutoff values for UFGSI and FGSI were 8 and 6, respectively.
   CONCLUSION: Age and dissemination scores of diseases were important factors that cause mortality in patients with FG. However, an accurate scoring system is important in predicting patients to be treated in the intensive care unit (ICU). Patients with a UFGSI score above 8 face a higher risk of death and should be treated in the ICU.
C1 [Egin, Seracettin; Kamali, Sedat; Hot, Semih; Gokcek, Berk; Yesiltas, Metin; Duman, Mehmet Guray; Alemdar, Ali] Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Gen Surg, Istanbul, Turkiye.
C3 University of Health Sciences Turkey
RP Egin, S (通讯作者)，Saglik Bilimleri Univ, Prof Dr Cemil Tascioglu Sehir Hastanesi, Genel Cerrahi Klinigi, Istanbul, Turkiye.
EM seracettin_egin@hotmail.com
RI Eğin, Seracettin/GQZ-0908-2022; Gökçek, Berk/X-9343-2018; duman, mehmet
   guray/HSE-5183-2023; Alemdar, Ali/HKV-6078-2023; Yeşiltaş,
   Metin/R-3639-2018
OI Yeşiltaş, Metin/0000-0002-2080-1572
CR Bronder C S, 2004, Colorectal Dis, V6, P518, DOI 10.1111/j.1463-1318.2004.00663.x
   Corcoran AT, 2008, J UROLOGY, V180, P944, DOI 10.1016/j.juro.2008.05.021
   Czymek R, 2010, LANGENBECK ARCH SURG, V395, P173, DOI 10.1007/s00423-008-0461-9
   Djafari AA, 2021, ARCH ACAD EMERG MED, V9, DOI 10.22037/aaem.v9i1.1123
   El-Qushayri AE, 2020, INT J INFECT DIS, V92, P218, DOI 10.1016/j.ijid.2019.12.030
   Marín AG, 2015, CIR ESPAN, V93, P12, DOI 10.1016/j.ciresp.2014.03.017
   Hahn HM, 2018, ANN SURG TREAT RES, V95, P324, DOI 10.4174/astr.2018.95.6.324
   Lin TY, 2014, INT J UROL, V21, P696, DOI 10.1111/iju.12426
   Ozturk E, 2011, COLORECTAL DIS, V13, P1044, DOI 10.1111/j.1463-1318.2010.02353.x
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Roghmann F, 2012, BJU INT, V110, P1359, DOI 10.1111/j.1464-410X.2012.11082.x
   Sarkut P, 2016, ULUS TRAVMA ACIL CER, V22, P541, DOI 10.5505/tjtes.2016.27095
   Sroczynski M, 2013, ADV CLIN EXP MED, V22, P131
   Thwaini A, 2006, POSTGRAD MED J, V82, P516, DOI 10.1136/pgmj.2005.042069
   Wróblewska M, 2014, POL J MICROBIOL, V63, P267
   Yavagal Sujata, 2011, Semin Plast Surg, V25, P121, DOI 10.1055/s-0031-1281481
   Yilmazlar T, 2010, TECH COLOPROCTOL, V14, P217, DOI 10.1007/s10151-010-0592-1
   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 18
TC 5
Z9 7
U1 0
U2 0
PU TURKISH ASSOC TRAUMA EMERGENCY SURGERY
PI ISTANBUL
PA KOPRULU MEHMET PASA SOC, DENIZ ABDAL MAH, DADASOGLU AP, 25-1 SEHREMINI,
   ISTANBUL, 00000, TURKEY
SN 1306-696X
EI 1307-7945
J9 ULUS TRAVMA ACIL CER
JI Ulus. Travma Acil Cerrahi Derg.
PD JAN
PY 2023
VL 29
IS 1
BP 109
EP 115
DI 10.14744/tjtes.2022.42738
PG 7
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 7M1AJ
UT WOS:000906387700016
PM 36588504
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Egin, S
   Kamali, S
   Hot, S
   Gökçek, B
   Yesiltas, M
AF Egin, Seracettin
   Kamali, Sedat
   Hot, Semih
   Gokcek, Berk
   Yesiltas, Metin
TI Comparison of Mortality in Fournier's Gangrene with the Two Scoring
   Systems
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Fournier's gangrene; Fournier's gangrene severity index; Uludag
   Fournier's gangrene severity index
ID SEVERITY INDEX; VALIDATION
AB Objective: To determine the factors associated with mortality in Fournier's gangrene (FG) toward informing the development of effective treatment strategies.
   Study Design: A descriptive study.
   Place and Duration of Study: Department of Surgery, University of Health Sciences, Okmeydani Education and Research Hospital, Istanbul, Turkey, from February 2012 to September 2017.
   Methodology: Informations of 30 patients treated for FG were examined retrospectively. The deceased patients (Group 1, n = 8) were analysed separately from the living ones (Group 2, n = 22). Informations in this analysis contained gender, age score, dissemination score, Uludag Fournier's Gangrene Severity Index (UFGSI) and Fournier's Gangrene Severity Index (FGSI) scores, serum levels of urea, infection source, the presence of diabetes, obesity, and other comorbidities, the presence of stoma for diversion, duration of the vacuum-assisted closure treatment, hospitalisation time, intensive care period, and species of bacteria isolated.
   Results: The overall mortality rate was detected as 26%. A significant difference between the two groups concerning age score of UFGSI parameters was found. The dissemination score of the infection, which is one of the UFGSI parameters, was significantly higher in Group 1 than in Group 2. According to UFGSI and FGSI scores, the scores of group 1 patients were significantly higher. To determine the incidence of mortality, the UFGSI and FGSI had 87.5% sensitivity and had 96% and 91% specificity, respectively. The cut-off values for UFGSI and FGSI were 10 and seven, respectively.
   Conclusion: Based on the findings described in this study, age and dissemination scores from the UFGSI can be used to predict patient outcome. Patients with a UFGSI score greater than 10 have a higher mortality rate.
C1 [Egin, Seracettin; Kamali, Sedat; Hot, Semih; Gokcek, Berk; Yesiltas, Metin] Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Istanbul Okmeydani Training &
   Research Hospital
RP Egin, S (通讯作者)，Univ Hlth Sci, Okmeydani Educ & Res Hosp, Dept Surg, Istanbul, Turkey.
EM seracettin_egin@hotmail.com
RI Kamalı, Sedat/GRS-4734-2022; Eğin, Seracettin/GQZ-0908-2022;
   /ADG-3811-2022; Yeşiltaş, Metin/Q-8190-2019; Gökçek, Berk/X-9343-2018
OI Yeşiltaş, Metin/0000-0002-2080-1572; Gökçek, Berk/0000-0001-9989-4152
CR Corcoran AT, 2008, J UROLOGY, V180, P944, DOI 10.1016/j.juro.2008.05.021
   Czymek R, 2010, LANGENBECK ARCH SURG, V395, P173, DOI 10.1007/s00423-008-0461-9
   Andreu MG, 2015, CIR ESPAN, V93, P127, DOI 10.1016/j.ciresp.2013.05.009
   Hahn HM, 2018, ANN SURG TREAT RES, V95, P324, DOI 10.4174/astr.2018.95.6.324
   Lin TY, 2014, INT J UROL, V21, P696, DOI 10.1111/iju.12426
   Morpurgo E, 2002, SURG CLIN N AM, V82, P1213, DOI 10.1016/S0039-6109(02)00058-0
   Ozturk E, 2011, COLORECTAL DIS, V13, P1044, DOI 10.1111/j.1463-1318.2010.02353.x
   Ozturk E, 2009, AM J SURG, V197, P660, DOI 10.1016/j.amjsurg.2008.04.018
   Roghmann F, 2012, BJU INT, V110, P1359, DOI 10.1111/j.1464-410X.2012.11082.x
   Sroczynski M, 2013, ADV CLIN EXP MED, V22, P131
   Taviloglu K, 2005, AM SURGEON, V71, P315
   Thwaini A, 2006, POSTGRAD MED J, V82, P516, DOI 10.1136/pgmj.2005.042069
   Ulug M, 2009, INT J INFECT DIS, V13, pE424, DOI 10.1016/j.ijid.2009.01.021
   Wróblewska M, 2014, POL J MICROBIOL, V63, P267
   Yilmazlar T, 2010, TECH COLOPROCTOL, V14, P217, DOI 10.1007/s10151-010-0592-1
   Yilmazlar T, 2014, ULUS TRAVMA ACIL CER, V20, P333, DOI 10.5505/tjtes.2014.06870
NR 16
TC 10
Z9 12
U1 0
U2 2
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
EI 1681-7168
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD JAN
PY 2020
VL 30
IS 1
BP 67
EP 72
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KC9QU
UT WOS:000507507200016
PM 31931936
OA gold
DA 2026-07-24
ER

PT J
AU Becker, CA
   Kammerlander, C
   Greiner, A
   Sommer, F
   Linhart, C
   Böcker, W
   Rubenbauer, B
   Weidert, S
AF Becker, Christopher A.
   Kammerlander, Christian
   Greiner, Axel
   Sommer, Fabian
   Linhart, Christoph
   Boecker, Wolfgang
   Rubenbauer, Bianka
   Weidert, Simon
TI Diagnostic and Treatment Strategies in Morel-Lavallee Lesions in the
   Spinal Column and Pelvis
SO ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
LA German
DT Article
DE pelvic fracture; spine fracture; soft tissue injury; closed degloving
   injury; Morel-Lavallee
ID SOFT-TISSUE INJURIES; CLOSED DEGLOVING INJURIES; OF-THE-LITERATURE;
   ACETABULAR FRACTURES; INTERNAL-FIXATION; WOUND CLOSURE; MANAGEMENT;
   TRAUMA
AB Background The Morel-Lavallee lesion is one of the concomitant soft tissue lesions of pelvic fractures. Its role in spine fractures and its treatment in combination with osteosynthesis of pelvic or spine fractures have not yet been determined. The aim of this study was to analyse the best diagnostic and treatment options of both spine and pelvic fractures combined with Morel-Lavallee lesions (MLL).
   Methods An analysis of the literature was performed via PubMed and Medline. This revealed a total of 197 studies and case reports. After analysing the literature, 19 studies/case reports met our inclusion criteria.
   Results There are several diagnostic options for MLL, including ultrasound, computed tomography or MRI. In spinal and pelvic lesions, ultrasound is capable of detecting MLL. Some authors tend to perform open debridement of the MLL, whereas others recommend percutanous treatment. Open debridement and vacuum-assisted closure are recommended in late diagnosed MLL, where primary suture of the soft tissue is impossible. Fracture fixation should be performed simultaneously to treatment of the MLL. Broad-spectrum cephalosporins combined with an aminoglycoside or piperacilline/tazobactam should be initiated.
   Conclusion Radical debridement and drainage are recommended, especially when MLL is diagnosed late. Repeated ultrasound examinations should be performed of the surrounding soft tissue of the fracture. When MU is diagnosed within 2 days, percutanous fracture and MU. treatment should be performed. After more than 2 days, both fracture and MLL should be treated with open debridement, open fracture fixation and primary suture if possible.
C1 [Becker, Christopher A.; Kammerlander, Christian; Greiner, Axel; Sommer, Fabian; Linhart, Christoph; Boecker, Wolfgang; Rubenbauer, Bianka; Weidert, Simon] Klinikum Ludwig Maximilians Univ Munchen, Klin Allgemeine Unfall Hand & Plast Chirurg, Munich, Germany.
RP Becker, CA (通讯作者)，Klin Allgemeine Unfall & Wiederherstellungschirur, Marchioninistr 15, D-81377 Munich, Germany.
EM christopher.becker@med.uni-muenchen.de
RI Kammerlander, Christian/Z-2246-2019
OI Linhart, Christoph/0000-0001-7349-7458
CR Bianchi S, 2007, MED RADIOL DIAGN IMA, P1, DOI 10.1007/978-3-540-28163-4
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NR 30
TC 3
Z9 5
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1864-6697
EI 1864-6743
J9 Z ORTHOP UNFALLCHIR
JI Z. Orthop. Unfallchir.
PD OCT
PY 2018
VL 156
IS 5
BP 541
EP 546
DI 10.1055/a-0596-8018
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA GW2NJ
UT WOS:000446720200016
PM 29649850
DA 2026-07-24
ER

PT J
AU Blume, P
   Wu, S
AF Blume, Peter
   Wu, Stephanie
TI Updating the Diabetic Foot Treatment Algorithm: Recommendations on
   Treatment Using Advanced Medicine and Therapies
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic foot ulcers; diabetes; chronic wounds; wound care; wound
   management
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; CLASSIFICATION-SYSTEM;
   ROBUST PREDICTOR; GROWTH-FACTORS; 4-WEEK PERIOD; ULCERS; MANAGEMENT;
   CARE; MULTICENTER
AB Objective. Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment. Materials and Methods. A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library. Diabetic foot ulcer treatment algorithms were reviewed and changes were recommended based on current standards of care, new treatment modalities, and clinical experience. Results. A multidisciplinary approach is recommended to address potential underlying problems. A visual inspection, foot pulse palpation, skin temperature measurement, and shoe gear, gait, orthopedic, neurologic, and vascular exams are recommended. Appropriate offloading and continuing diabetes education are included as treatment for all DFUs. If calluses or increased foot pressure are present, preventative care is necessary to prevent further tissue breakdown. If infection is present, treatment should follow the Infectious Diseases Society of America diabetic foot infection guidelines. As the DFU severity increases, advanced wound dressings and therapies should be employed. In acute/chronic and acute/urgent DFUs, debridement, amputation, and skin grafting may be required. Conclusions. Treatment for DFUs should start when a possible pre-ulcer is noticed. This prophylactic treatment may reduce development of more severe DFUs. Once a DFU has developed, care should be optimized for both the patient and the wound bed. While these treatment recommendations are focused solely on DFUs, they may be expanded for use in other foot/leg pressure ulcers.
C1 [Blume, Peter] Yale Univ, Sch Med, Anesthesia & Orthoped & Rehabil, New Haven, CT USA.
   [Wu, Stephanie] Rosalind Franklin Univ Med & Sci, CLEAR, Dr William M Sch Coll Podiat Med, N Chicago, IL USA.
C3 Yale University; Rosalind Franklin University of Medicine & Science
RP Blume, P (通讯作者)，Yale Sch Med, Anesthesia & Orthoped & Rehabil, 500 Blake St, New Haven, CT 06515 USA.
EM peterb@ctfootandanklesurgery.com
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NR 47
TC 38
Z9 52
U1 1
U2 15
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2018
VL 30
IS 2
BP 29
EP 35
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GB3XM
UT WOS:000428993700003
PM 29091034
DA 2026-07-24
ER

PT J
AU Dondossola, D
   Cavenago, M
   Piconi, S
   Antonelli, B
   Melada, E
   Lonati, C
   Gatti, S
   Rossi, G
AF Dondossola, D.
   Cavenago, M.
   Piconi, S.
   Antonelli, B.
   Melada, E.
   Lonati, C.
   Gatti, S.
   Rossi, G.
TI Negative Pressure Wound Treatment of Infections Caused By Extensively
   Drug-Resistant Gram-Negative Bacteria After Liver Transplantation: Two
   Case Reports
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article; Proceedings Paper
CT 38th National Congress of the Italian-Transplantation-Society
CY SEP 24-26, 2014
CL Siena, ITALY
SP Italian Transplantat Soc
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; FUNGAL-INFECTIONS;
   INSTILLATION; THERAPY; SUSCEPTIBILITY; COMPLICATIONS; RECIPIENTS; PERIOD
AB Although survival after liver transplantation (LT) has progressively improved over the last years, an increased prevalence of clinically relevant infections in LT patients is well documented. In particular, the spread of infections sustained by extensively drug-resistant bacteria (XDR) produced an increase in the incidence of wound infections. Implementation of treatments for these life-threatening events is mandatory. This study describes 2 LT patients in whom XDR wound infection was effectively treated using negative pressure wound treatment (NPWT) combined with targeted local and systemic antibiotic therapy. Over the last 3 years, 2 of 8 patients with XDR infection admitted to our unit developed wound infection caused by XDR Klebsiella pneumoniae (KP-XDR). Positive results of the abdominal fluid culture and of the wound swab for KP-XDR were followed by sepsis. In both cases wound debridement was required and deep fascial layer dehiscence was detected. Combination antibiotic therapy was administered for sepsis treatment and, after failure of conventional NPWT, a NPWT with local instillation (NPWTi; V.A.C.-Ulta/ Vera Flo-Instillation Therapy-KCI USA, Inc., San Antonio, TX, USA) of colistinrifampicin was applied. After NPWTi application a reduction in bacterial load and exudate was observed with reduction in inflammatory markers. A complete healing of wound was achieved and both patients are currently alive. Instillation and NPWT are widely discussed in the literature. Results of the present study indicate beneficial effects of NPWT combined with targeted local and systemic antibiotic therapy; in both cases a life-threatening complication was cured. We consider local instillation of selected antibiotics applied to NPWTi a valuable tool for deep wound infection sustained by XDR bacteria.
C1 [Dondossola, D.; Cavenago, M.; Antonelli, B.; Melada, E.; Lonati, C.; Gatti, S.; Rossi, G.] IRCCS Ca Granda Osped Maggiore Policlin Milano, Hepatobiliarypancreat Surg Unit, Milan, Italy.
   [Piconi, S.] Azienda Osped Luigi Sacco, Infect Dis Unit, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   Luigi Sacco Hospital
RP Dondossola, D (通讯作者)，IRCCS Ca Granda Osped Maggiore Policlin Milano, Hepatobiliarypancreat Surg Unit, Via F Sforza, Milan, Italy.
EM dondossola.daniele@gmail.com
RI Gatti, Stefano/M-1780-2015; Cavenago, Marco/N-4743-2018; lonati,
   caterina/ABI-1503-2020; Rossi, Giorgio/M-3445-2015; dondossola,
   daniele/A-7978-2016
OI Gatti, Stefano/0000-0003-2209-4338; lonati,
   caterina/0000-0001-7855-7851; Rossi, Giorgio/0000-0002-5588-1306;
   dondossola, daniele/0000-0002-4374-3184; Antonelli,
   Barbara/0000-0001-8435-1294
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 8
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD SEP
PY 2015
VL 47
IS 7
BP 2145
EP 2149
DI 10.1016/j.transproceed.2014.11.078
PG 5
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Surgery; Transplantation
GA CR8ZW
UT WOS:000361644000015
PM 26361664
DA 2026-07-24
ER

PT J
AU Filsouti, F
   Rahmanian, PB
   Castillo, JG
   Pinney, S
   Broumand, SR
   Adams, DH
AF Filsouti, Farzan
   Rahmanian, Parwis B.
   Castillo, Javier G.
   Pinney, Sean
   Broumand, Stafford R.
   Adams, David H.
TI Incidence, treatment strategies and outcome of deep sternal wound
   infection after orthotopic heart transplantation
SO JOURNAL OF HEART AND LUNG TRANSPLANTATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BYPASS GRAFT-SURGERY; RISK-FACTORS;
   MEDIASTINITIS; EXPERIENCE
AB Background: Deep sternal wound infection (DSWI) after orthotopic heart transplantation (OHT) has not been well studied and its outcome remains largely unknown. Herein we report the incidence, clinical presentation, treatment strategies and early and late outcome after this complication.
   Methods: We retrospectively analyzed 149 consecutive patients (mean age 53 +/- 16 years, 113 [76%] males) who underwent OHT between January 1998 and December 2005. Mean body mass index (BMI) was 27 +/- 6 kg/m(2) and 30 (20%) patients were diabetics. Sixty (40%) patients had prior cardiac surgery, 11 (7%) underwent previous ventricular assist device (VAD) implantation, and 10 (7%.) were in a critical hemodynamic state requiring inotropic support.
   Results: DSWI occurred in 13 (8.7%) patients as compared with 1.7% of patients in our general cardiac surgery population (p < 0.001). Predictors of DSWI in univariate analyses were BMI > 30 kg/m(2) (p = 0.02), previous heart surgery (p = 0.03), previous VAD (p = 0.006) and inotropic support (p = 0.04). Hospital mortality after DSWI was significantly increased as compared with patients without this complication (31% vs 8%, p 0.03). One- and 5-year survival after DSWI was 100 -12% and 80 +/- 18% as compared with 92 +/- 3% and 82 +/- 4% in patients without DSWI (p = 0.8).
   Conclusions DSWI after OHT is a common complication and carries high mortality and morbidity rates. We were able to identify specific risk factors for this condition, such as prior VAD insertion and pre-operative inotropic support. Long-term survival after DSWI remains similar to that of transplant patients without this complication. J Heart Lung Transplant 2007;26:1084-90. Copyright (c) 2007 by the International Society for Heart and Lung Transplantation.
C1 Mt Sinai Sch Med, Dept Cardiothorac Surg, New York, NY 10029 USA.
   Mt Sinai Sch Med, Inst Cardiovasc, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Filsouti, F (通讯作者)，Mt Sinai Sch Med, Dept Cardiothorac Surg, 1190 Fifth Ave, New York, NY 10029 USA.
EM farzan.filsoufi@mountsinai.org
RI Pinney, Sean/AFP-4645-2022; Rahmanian, Parwis Baradaran/E-5862-2010;
   Gonzalez-Castillo, Javier/B-6903-2012
OI Pinney, Sean/0000-0002-0268-7817; Rahmanian, Parwis
   Baradaran/0000-0002-3978-9251; 
CR Abboud CS, 2004, ANN THORAC SURG, V77, P676, DOI 10.1016/S0003-4975(03)01523-6
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NR 16
TC 32
Z9 35
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1053-2498
J9 J HEART LUNG TRANSPL
JI J. Heart Lung Transplant.
PD NOV
PY 2007
VL 26
IS 11
BP 1084
EP 1090
DI 10.1016/j.healun.2007.07.036
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery;
   Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery;
   Transplantation
GA 237VJ
UT WOS:000251404200002
PM 18022072
DA 2026-07-24
ER

PT J
AU Saricaoglu, MC
   Kandemir, M
   Saricaoglu, EM
   Karacuha, AF
   Kadiroglu, E
   Abdullahi, MF
   Inan, MB
   Azap, A
   Akar, AR
AF Saricaoglu, Mehmet Cahit
   Kandemir, Melisa
   Saricaoglu, Elif M.
   Karacuha, Ali Fuat
   Kadiroglu, Ezel
   Abdullahi, Mustafa Farah
   Inan, Mustafa Bahadir
   Azap, Alpay
   Akar, Ahmet Ruchan
TI Driveline Relocation and Vacuum-Assisted Closure for Ventricular Assist
   Device Driveline Infections
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE left ventricular assist devices; driveline infections; microorganisms;
   driveline dressing
ID OUTCOMES
AB Background: Durable mechanical circulatory support (DMCS) infections remain a serious challenge. Ventricular assist device (VAD)-specific driveline infections (DLIs) are the most common type; however, no consensus exists on their surgical management. We aimed to define the incidence, risk factors, and microbiology of DLIs and discuss the surgical treatment modalities. Methods: We retrospectively reviewed 90 patients who underwent a left or biventricular ventricular assist device (LVAD or BiVAD) implantation with either a HeartMate 2 (Abbott), HeartWare HVAD (Medtronic), or HeartMate 3 (Abbott) in a single center between 1 March 2011 and 30 May 2023. Results: DLIs were detected in 20 (21.5%) patients during the follow-up. The mean duration of VAD support was 561.1 +/- 833.2 days (1-4124 days), while it was 1277.9 +/- 621.6 days in the DLI group. An extended duration of VAD support was associated with higher incidence rates of late-onset DLIs (p < 0.05). A younger age and lower plasma albumin levels were independent predictive factors for the risk of a DLI, with a hazard ratio of 9.77 (95%CI: 1.3-74.5) and 10.55 (95%CI: 1.40-79.35), respectively. The removal of the biofilm with velour and DL relocation through the rectus muscle combined with vacuum-assisted strategies (VAC) were performed in nine patients. One patient developed a recurrent infection, and another patient with a deep DLI subsequently received a heart transplant. No patient underwent a device exchange for an intractable DLI. Conclusions: Our results suggest that DLIs are common infectious complications after VAD implantation, which endanger patient autonomy, and impair their quality of life and overall survival. A DL relocation through the rectus muscles and VAC strategies have a role in controlling DLIs.
C1 [Saricaoglu, Mehmet Cahit; Kandemir, Melisa; Karacuha, Ali Fuat; Kadiroglu, Ezel; Abdullahi, Mustafa Farah; Inan, Mustafa Bahadir; Akar, Ahmet Ruchan] Ankara Univ, Cebeci Hosp, Heart Ctr, Dept Cardiovasc Surg,Sch Med, TR-06340 Ankara, Turkiye.
   [Saricaoglu, Elif M.; Azap, Alpay] Ankara Univ, Ibni Sina Hosp, Sch Med, Dept Infect Dis & Clin Microbiol, TR-06340 Ankara, Turkiye.
C3 Ankara University; Ankara University
RP Akar, AR (通讯作者)，Ankara Univ, Cebeci Hosp, Heart Ctr, Dept Cardiovasc Surg,Sch Med, TR-06340 Ankara, Turkiye.
EM saricaoglu@ankara.edu.tr; melisakandemir1999@gmail.com;
   esaricaoglu@ankara.edu.tr; alifuatkaracuha@gmail.com;
   elifezelkadiroglu@gmail.com; mustaf.59@hotmail.com;
   mbinan@ankara.edu.tr; alpayazap@gmail.com; akar@ankara.edu.tr
RI Sarıcaoğlu, Mehmet Cahit/AEM-6681-2022; KARACUHA,
   Ali'Fuat/LGY-4166-2024; Akar, Ahmet Rüçhan/C-9905-2009; Saricaoglu,
   Elif/JNS-2605-2023; Azap, Alpay/KMA-1874-2024
OI Kandemir, Melisa/0000-0003-2536-3820; Azap, Alpay/0000-0001-5035-055X;
   KARAÇUHA, ALİ FUAT/0009-0000-4280-6289
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NR 36
TC 0
Z9 0
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD JUN 3
PY 2025
VL 12
IS 6
AR 211
DI 10.3390/jcdd12060211
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 4LP8I
UT WOS:001520943200001
PM 40558646
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Chong, JH
   Zhang, Y
   Harky, A
   Field, M
AF Chong, Jun Heng
   Zhang, Yi
   Harky, Amer
   Field, Mark
TI Management and Outcomes of Proximal Aortic Graft Infection: A Systematic
   Review
SO HEART LUNG AND CIRCULATION
LA English
DT Review
DE Aorta; Graft infection; Prosthesis; Wound management
ID PROSTHETIC GRAFT; THORACIC AORTA; OMENTAL FLAP; CASE SERIES;
   REPLACEMENT; CLOSURE; ENDOCARDITIS
AB Objective Proximal aortic graft infection (PAGI) is a rare but often fatal postoperative complication. Its management often relied on surgical preferences and resource availability of each centre, until the recent unifying guidelines published by the European Society for Vascular Surgery (ESVS). This paper aimed to amalgamate the published experience in managing PAGI and their outcomes.
   Methods PubMed, Scopus and Cochrane Library databases were searched systematically. All primary studies besides single-patient case reports were included. Data extracted included study and patient characteristics, type of index surgery, type of microorganisms involved, definitive treatment modality, and any outcome measures reported.
   Results Of the 20 studies included, 157 of the 290 PAGI patients underwent complete graft explantation and replacement, 106 underwent graft-preservation interventions (debridement and/or irrigation), and 25 had antibiotics alone. Adjunctive interventions included graft coverage, vacuum-assisted closure, use of infection-resistant graft materials, and lifelong suppressive therapy. In-hospital mortality was 20.8% (n=60), with postoperative sepsis and multiorgan failure (n=24) being the most common cause. Recurrent infection occurred in 10 post-discharge patients. Post-discharge mortality rate was 11.4% (n=33), with cardiac complications and stroke being the most common cause in surgically-treated and medically-treated patients, respectively.
   Conclusions Given the risk of mortality, the management approach of PAGI highly depends on the fitness of the patient. We believe that early referral to specialised aortic centres is essential to plan for optimal management strategies and improve patient outcomes. Further studies are also required to parse out the most effective adjunctive interventions to maximise patient outcomes.
C1 [Chong, Jun Heng] Kings Coll London, GKT Sch Med Educ, London, England.
   [Zhang, Yi] Barts & London Queen Marys Sch Med & Dent, London, England.
   [Harky, Amer; Field, Mark] Liverpool Heart & Chest, Dept Cardiothorac Surg, Liverpool, Merseyside, England.
C3 University of London; King's College London; University of London; Queen
   Mary University London; Liverpool Heart & Chest Hospital
RP Harky, A (通讯作者)，Liverpool Heart & Chest Hosp, Dept Cardiothorac Surg, Liverpool L14 3PE, Merseyside, England.
EM aaharky@gmail.com
RI Chong, James/E-2924-2018; Harky, Amer/AAO-2125-2020
OI Harky, Amer/0000-0001-5507-5841; Chong, Jun Heng/0009-0007-1482-9759
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NR 31
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1443-9506
EI 1444-2892
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD JAN
PY 2022
VL 31
IS 1
BP 49
EP 58
DI 10.1016/j.hlc.2021.07.026
EA DEC 2021
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XS7UO
UT WOS:000733109100013
PM 34602347
DA 2026-07-24
ER

EF