﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Marston, WA
   Armstrong, DG
   Reyzelman, AM
   Kirsner, RS
AF Marston, William A.
   Armstrong, David G.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI A Multicenter Randomized Controlled Trial Comparing Treatment of Venous
   Leg Ulcers Using Mechanically Versus Electrically Powered Negative
   Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; SURROGATE END-POINTS; CARE;
   INSUFFICIENCY; MANAGEMENT; ULCERATION; SYSTEM; IMPACT
AB Objective: This study compares two different negative pressure wound therapy (NPWT) modalities in the treatment of venous leg ulcers (VLUs), the ultraportable mechanically powered (MP) Smart Negative Pressure (SNaP (R)) Wound Care System to the electrically powered (EP) Vacuum-Assisted Closure (V.A.C.(R)) System.
   Approach: Patients with VLUs from 13 centers participated in this prospective randomized controlled trial. Each subject was randomly assigned to treatment with either MP NPWT or EP NPWT and evaluated for 16 weeks or complete wound closure.
   Results: Forty patients (n = 19 MP NPWT and n = 21 EP NPWT) completed the study. Primary endpoint analysis of wound size reduction found wounds in the MP NPWT group had significantly greater wound size reduction than those in the EP NPWT group at 4, 8, 12, and 16 weeks (p-value = 0.0039, 0.0086, 0.0002, and 0.0005, respectively). Kaplan-Meier analyses showed greater acceleration in complete wound closure in the MP NPWT group. At 30 days, 50% wound closure was achieved in 52.6% (10/19) of patients treated with MP NPWT and 23.8% (5/21) of patients treated with EP NPWT. At 90 days, complete wound closure was achieved in 57.9% (11/19) of patients treated with MP NPWT and 38.15% (8/21) of patients treated with EP NPWT.
   Innovation: These data support the use of MP-NPWT for the treatment of VLUs.
   Conclusions: In this group of venous ulcers, wounds treated with MP NPWT demonstrated greater improvement and a higher likelihood of complete wound closure than those treated with EP NPWT.
C1 [Marston, William A.] Univ N Carolina, Dept Surg, Div Vasc Surg, Sch Med, Chapel Hill, NC 27599 USA.
   [Armstrong, David G.] Univ Arizona, Coll Med, SALSA, Tucson, AZ USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Calif Sch Podiatr Med, Dept Med, Oakland, CA USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of Arizona;
   Samuel Merritt University; University of Miami
RP Marston, WA (通讯作者)，Univ N Carolina, Dept Surg, Div Vasc Surg, Sch Med, Chapel Hill, NC 27599 USA.
EM sky@med.unc.edu
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NR 41
TC 14
Z9 18
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD FEB
PY 2015
VL 4
IS 2
BP 75
EP 82
DI 10.1089/wound.2014.0575
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8XP
UT WOS:000357257800001
PM 25713749
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Blume, PA
   Walters, J
   Payne, W
   Ayala, J
   Lantis, J
AF Blume, Peter A.
   Walters, Jodi
   Payne, Wyatt
   Ayala, Jose
   Lantis, John
TI Comparison of negative pressure wound therapy using vacuum-assisted
   closure with advanced moist wound therapy in the treatment of diabetic
   foot ulcers: A multicenter randomized controlled trial
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Podiatric-Medicine
CY AUG 16-19, 2007
CL Philadelphia, PA
SP Amer Podiatr Med
AB OBJECTIVE - The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy (AMWT) to treat foot ulcers in diabetic patients.
   RESEARCH DESIGN AND METHODS- This multicenter randomized controlled trial enrolled 342 patients with a mean age of 58 years; 79% were male, Complete ulcer closure was defined as skin closure (100% reepithelization) without drainage or dressing requirements. Patients were randomly assigned to either NPWT (vacuum-assisted closure) or AMWT (predominately hydrogels and alginates) and received standard off-loading therapy as needed. The trial evaluated treatment until day 112 or ulcer closure by any means. Patients whose wounds achieved ulcer closure were followed at 3 and 9 months. Each study visit included closure assessment by wound examination and tracings.
   RESULTS - A greater proportion of foot ulcers achieved complete ulcer closure with NPWT (73 of 169, 43.2%) than with AMWT (48 of 166, 28.9%) within the 112-day active treatment phase (P = 0.007). The Kaplan-Meier median estimate for 100% ulcer closure was 96 days (95% CI 75.0-114.0) for NPWT and not determinable for AMWT (P = 0.001). NPWT patients experienced significantly (P = 0.035) fewer secondary amputations. The proportion of home care therapy days to total therapy days for NPWT was 9,471 of 10,579 (89.5%) and 12,210 of 12,810 (95.3%) for AMWT. In assessing safety, no significant difference between the groups was observed in treatment-related complications such as infection, cellulitis, and osteomyelitis at 6 months.
   CONCLUSIONS - NPWT appears to be as safe as and more efficacious than AMWT for the treatment of diabetic foot ulcers.
C1 [Blume, Peter A.] N Amer Ctr Limb Preservat, New Haven, CT 06515 USA.
   [Walters, Jodi] So Arizona Vet Affairs Med Ctr, Tucson, AZ USA.
   [Payne, Wyatt] Bay Pines VA Healthcare Syst, Inst Tissue Regenerat Repair & Rehabil, Bay Pines, FL USA.
   Univ S Florida, Div Plast Surg, Tampa, FL USA.
   [Ayala, Jose] Valley Baptist Hosp, Brownsville, TX USA.
   [Lantis, John] St Lukes Roosevelt Hosp, New York, NY 10025 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Southern Arizona Veterans Affairs Health Care System; State University
   System of Florida; University of South Florida; Mount Sinai Morningside;
   Mount Sinai West
RP Blume, PA (通讯作者)，N Amer Ctr Limb Preservat, 506 Blake St, New Haven, CT 06515 USA.
EM peter.b@snet.net
CR [Anonymous], GUID MAN WOUNDS PAT
   [Anonymous], 2005, NAT DIAB FACT SHEET
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NR 20
TC 451
Z9 542
U1 3
U2 70
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2008
VL 31
IS 4
BP 631
EP 636
DI 10.2337/dc07-2196
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 282UE
UT WOS:000254591900001
PM 18162494
OA Bronze
DA 2026-07-24
ER

PT J
AU Nguyen, TQ
   Franczyk, M
   Lee, JC
   Greives, MR
   O'Connor, A
   Gottlieb, LJ
AF Nguyen, Trang Q.
   Franczyk, Mieczyslawa
   Lee, Justine C.
   Greives, Matthew R.
   O'Connor, Annemarie
   Gottlieb, Lawrence J.
TI Prospective Randomized Controlled Trial Comparing Two Methods of
   Securing Skin Grafts Using Negative Pressure Wound Therapy:
   Vacuum-Assisted Closure and Gauze Suction
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DEVICE; BOLSTER
AB Negative pressure wound therapy (NPWT) has revolutionized the management of complicated wounds and has contributed an additional modality for securing split thickness skin grafts (STSG). The standard for NPWT is the vacuum-assisted closure (VAC) device. The authors' institution has accumulated experience using standard gauze sealed with an occlusive dressing and wall suction (GSUC) as their primary mode for NPWT. The authors report a randomized controlled trial comparing the efficacy of the GSUC vs the VAC in securing STSG. A prospective, randomized, controlled trial was conducted in 157 wounds in 104 patients requiring STSG from August 2009 to July 2012. All wounds were randomized to VAC or GSUC treatment and assessed for skin graft adherence/take. At postoperative day 4 or 5, NPWT was discontinued, and the size of the graft and any nonadherent areas were measured and recorded. Concomitant comorbidities, wound location, etiology, study failures, and reoperative rates were also reviewed. In all, 77 and 80 wounds were randomized to the GSUC and VAC study arms. Patient demographics were similar between both groups in terms of age, sex, comorbidities, etiology, and wound location. In all, 64 of 80 wounds in the GSUC group and 60 of 77 wounds in the VAC group had full take of the skin graft by postoperative day 4 or 5 (P = .80). The mean percent take in the GSUC group was 96.12% vs 96.21% in the VAC arm (P = .98). The use of NPWT in securing STSG is a useful method to promote adherence and healing. This study demonstrates that a low-cost, readily accessible system utilizing gauze dressings and wall suction (GSUC) results in comparable skin graft take in comparison to the VAC device.
C1 [Nguyen, Trang Q.; Greives, Matthew R.; O'Connor, Annemarie; Gottlieb, Lawrence J.] Univ Chicago Med, Sect Plast & Reconstruct Surg, Dept Surg, Chicago, IL USA.
   [Franczyk, Mieczyslawa] Univ Chicago Med, Dept Therapy Serv, Chicago, IL USA.
   [Lee, Justine C.] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA 90095 USA.
C3 University of Chicago; University of Chicago; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA
RP Gottlieb, LJ (通讯作者)，Univ Chicago, Dept Surg, 5841 South Maryland Ave,MC 6035, Chicago, IL 60637 USA.
OI Lee, Justine C/0000-0002-8943-0837; Greives, Matthew/0000-0003-4602-5054
FU Barbara White Gift Fund
FX This study was supported by the Dean and Barbara White Gift Fund.
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NR 16
TC 24
Z9 30
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2015
VL 36
IS 2
BP 324
EP 328
DI 10.1097/BCR.0000000000000089
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA CC5JO
UT WOS:000350395100029
PM 25162948
DA 2026-07-24
ER

PT J
AU Zhu, J
   Yu, AX
   Qi, BW
   Li, ZH
   Hu, X
AF Zhu, Jin
   Yu, Aixi
   Qi, Baiwen
   Li, Zonghuan
   Hu, Xiang
TI Effects of Negative Pressure Wound Therapy on Mesenchymal Stem Cells
   Proliferation and Osteogenic Differentiation in a Fibrin Matrix
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; HYDROSTATIC-PRESSURE;
   MECHANICAL STRAIN; BONE REGENERATION; STRETCH PROMOTES; VIABILITY;
   PATHWAYS
AB Vacuum-assisted closure (VAC) negative pressure wound therapy (NPWT) has been proven to be an effective therapeutic method for the treatment of recalcitrant wounds. However, its role in bone healing remains to be unclear. Here, we investigated the effects of NPWT on rat periosteum-derived mesenchymal stem cells (P-MSCs) proliferation and osteoblastic differentiation in a 3D fibrin matrix. P-MSCs underwent primary culture for three passages before being used to construct cell clots. The fibrin clots were incubated with NPWT under continuous suction at -125 mmHg in a subatmospheric perfusion bioreactor. Clots exposed to atmospheric pressure served as the static control. Compared to the control group, cell proliferation significantly increased in NPWT group after incubation for 3 days. There was no statistical difference in apoptosis rate between two groups. The ALP activity and mineralization of P-MSCs all increased under continuous suction. The expressions of collagen type 1 and transcription factor Cbfa-1 were higher at the 1-, 3-, and 7-day timepoints and the expressions of osteocalcin and integrin beta 5 were higher at the 3-, and 7-day timepoints in the NPWT group. These results indicate that a short time treatment with NPWT, applied with continuous suction at 2125 mmHg, can enhance cellular proliferation of P-MSCs and induce the differentiation toward an osteogenic phenotype. The mechanotransduction molecule integrin beta 5 was found to be highly expressed after NPWT treatment, which indicates that NPWT may play a positive role in fracture healing through enhance bone formation and decrease bone resorption.
C1 [Zhu, Jin; Yu, Aixi; Qi, Baiwen; Li, Zonghuan; Hu, Xiang] Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430072, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Microorthoped, Wuhan 430072, Peoples R China.
EM yuaixi666@hotmail.com
FU National Natural Science Foundation of China [81171713]; Hubei
   Provience's Outstanding Medical Academic Leader Program
FX This study was supported by the National Natural Science Foundation of
   China (no. 81171713) and the Hubei Provience's Outstanding Medical
   Academic Leader Program. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 37
TC 19
Z9 22
U1 1
U2 34
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 12
PY 2014
VL 9
IS 9
AR e107339
DI 10.1371/journal.pone.0107339
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AP0SM
UT WOS:000341774300059
PM 25216182
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dastouri, P
   Helm, DL
   Scherer, SS
   Pietramaggiori, G
   Younan, G
   Orgill, DP
AF Dastouri, Pouya
   Helm, Douglas L.
   Scherer, Saja S.
   Pietramaggiori, Giorgio
   Younan, George
   Orgill, Dennis P.
TI Waveform Modulation of Negative-Pressure Wound Therapy in the Murine
   Model
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 95th Annual Clinical Congress of the American-College-of-Surgeons/64th
   Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical
   Problems
CY OCT 11-15, 2009
CL Chicago, IL
SP Amer Coll Surg
ID VACUUM-ASSISTED CLOSURE; CELL; ANGIOGENESIS; FORCES; SKIN; VEGF; STRETCH
AB Background: Negative-pressure wound therapy applied with a porous foam interface has been shown to accelerate granulation-tissue formation when a cyclic application mode of suction is applied, but the optimal waveform has not been determined. The authors hypothesized that changes in the suction waveform applied to wounds would modulate the biological response of granulation tissue formation.
   Methods: A vacuum-assisted closure device (Kinetic Concepts, Inc., San Antonio, Texas) was applied to full-thickness wounds in 48 male diabetic mice (C57BL/KsJ-Lepr db), which were treated with six different waveforms: square waveforms of 125 mmHg of suction for 2 minutes, alternating with 50 mmHg of suction for 2 minutes, 5 minutes, or 10 minutes; triangular waveform with a 7-minute period oscillating between 50 and 125 mmHg; and static suction at 125 mmHg or static suction at 0 mmHg (occlusive dressing). Wounds were quantitatively evaluated for granulation tissue thickness as well as the number of proliferating cells and the number of blood vessels of the newly formed granulation tissue.
   Results: At 7 days, the continuous and triangular waveforms induced the thickest granulation tissue, with high rates of cellular proliferation and blood vessel counts compared with square wave and occlusive dressing control wounds. Decreasing square waveform frequency significantly increased granulation tissue thickness, cellular proliferation, and blood vessel counts.
   Conclusions: Waveform modulation has a significant effect on granulation tissue formation, angiogenesis, and cellular proliferation in excisional wounds in diabetic mice. The rapid change in pressure seen in our square wave model may be detrimental to granulation tissue formation. (Plast. Reconstr. Surg. 127: 1460, 2011.)
C1 [Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Hop Cantonal Univ Geneva, Div Plast Surg, Geneva, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; University of Geneva
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI ; Orgill, Dennis/H-7596-2019; PIETRAMAGGIORI, Giorgio/HJA-1920-2022
OI Younan, George/0000-0001-8502-4850; Orgill, Dennis/0000-0002-8279-7310; 
CR Azuma N, 2000, J VASC SURG, V32, P789, DOI 10.1067/mva.2000.107989
   Baker AB, 2000, MICROVASC RES, V60, P177, DOI 10.1006/mvre.2000.2252
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NR 19
TC 30
Z9 34
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0032-1052
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2011
VL 127
IS 4
BP 1460
EP 1466
DI 10.1097/PRS.0b013e31820a63cb
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 741CH
UT WOS:000288840200008
PM 21460654
DA 2026-07-24
ER

PT J
AU Lonie, S
   Hallam, J
   Yii, M
   Davis, P
   Newcomb, A
   Nixon, I
   Rosalion, A
   Ricketts, S
AF Lonie, Sarah
   Hallam, Jane
   Yii, Michael
   Davis, Philip
   Newcomb, Andrew
   Nixon, Ian
   Rosalion, Alexander
   Ricketts, Sophie
TI Changes in the management of deep sternal wound infections: a 12-year
   review
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE negative-pressure wound therapy; sternotomy; surgical wound infection;
   vacuum-assisted closure; wound closure technique
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   MUSCLE FLAPS; THERAPY; MODALITY; BRIDGE
AB BackgroundDeep sternal wound infection (DSWI) is a rare but life-threatening complication following cardiac surgery associated with increased morbidity and mortality. Management of these patients has evolved over the years and can include sternal rewiring, mediastinal irrigation, negative-pressure wound therapy (NPWT) dressing or repair with flaps. We reviewed changes in our management of DSWI and outcomes.
   MethodsUsing the Australian and New Zealand Society of Cardiac and Thoracic Surgeons database, 5472 underwent cardiac surgery at St Vincent's Hospital, Melbourne, and 42 were identified as developing DSWI requiring re-operation between June 2002 and September 2014. Data were collected pertaining to risk factors for DSWI, management strategies and outcomes. Patients were compared from a period prior to NPWT dressing use (June 2002-February 2006, n = 14) and since the NPWT has been used regularly in the management of DSWI (from March 2006, n = 28). Patients were also compared based on the requirement for flap closure of their sternal wound.
   ResultsBecause of the widespread use of NPWT dressings, there is a trend towards fewer sternal infections requiring flap closure (25 versus 42.8%) and less post-operative complications after definitive closure (7.1 versus 28.6%). Before and after widespread NPWT use, patients require similar number of re-operations before closure and have no significant differences in time to definitive closure or length of hospital stay.
   ConclusionThe use of NPWT dressings as a bridge to definitive closure may reduce the need for more burdensome flap reconstruction, does not delay definitive reconstruction or prolong hospital stay and may reduce post-reconstruction complications requiring re-operation.
C1 [Lonie, Sarah; Ricketts, Sophie] St Vincents Hosp, Dept Plast & Reconstruct Surg, Melbourne, Vic, Australia.
   [Lonie, Sarah; Hallam, Jane; Yii, Michael; Davis, Philip; Newcomb, Andrew; Nixon, Ian; Rosalion, Alexander] St Vincents Hosp, Dept Cardiothorac Surg, Melbourne, Vic, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St
   Vincents Hospital Sydney; NSW Health; St Vincents Hospital Sydney; St
   Vincent's Health; St Vincent's Hospital Melbourne
RP Lonie, S (通讯作者)，St Vincents Hosp, 41 Victoria Parade, Fitzroy, Vic 3065, Australia.
EM sjlonie88@gmail.com
RI Davis, Philip/A-9312-2011; Newcomb, Andrew/ABD-9220-2021; Lonie,
   Sarah/JXN-0672-2024
OI Newcomb, Andrew/0000-0002-0465-3602; Lonie, Sarah/0000-0001-8109-6507
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NR 25
TC 15
Z9 20
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD NOV
PY 2015
VL 85
IS 11
BP 878
EP 881
DI 10.1111/ans.13279
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CU9NY
UT WOS:000363872500020
PM 26331481
DA 2026-07-24
ER

PT J
AU Jang, HB
   Jung, EK
   Yoon, TM
   Lee, DH
   Lim, SC
   Lee, JK
AF Jang, Hye-Bin
   Jung, Eun Kyung
   Yoon, Tae Mi
   Lee, Dong Hoon
   Lim, Sang Chul
   Lee, Joon Kyoo
TI Efficiency of Endoluminal Vacuum-Assisted Closure Therapy for
   Pharyngocutaneous Fistula
SO JOURNAL OF CRANIOFACIAL SURGERY
LA English
DT Article
DE Cutaneous fistula; head and neck neoplasms; laryngoscopy;
   negative-pressure wound therapy; pharyngectomy
ID PRESSURE WOUND THERAPY; ORGAN PRESERVATION THERAPY; NEGATIVE-PRESSURE;
   TOTAL LARYNGECTOMY; ANASTOMOTIC LEAKAGE; HEAD; RADIATION; RESECTION
AB The aim of this study was to evaluate the efficacy of endoluminal vacuum-assisted closure (EndoVAC) therapy for patients with pharyngocutaneous fistula by placing a sponge in the intraluminal pharyngeal space using a transoral approach. The authors retrospectively enrolled 12 patients with pharyngocutaneous fistula, who were treated with EndoVAC therapy from 2023 to 2024. Of the 12 patients, 10 patients had pharyngocutaneous fistula after surgery for head and neck malignancy, 1 patient had a leak in the pharyngoesophageal junction caused by bougienage, and 1 patient had a pharyngocutaneous fistula associated with antiphospholipid syndrome. The average time for fistula detection after surgery was 7.27 +/- 1.68 days. Among the 12 patients, 5 patients were treated with EndoVAC alone, and 7 patients were treated with both EndoVAC and external negative pressure wound therapy (NPWT). The average number, duration, and an average change interval of EndoVAC procedures among all 12 patients was 2.91 +/- 0.41, 20.08 +/- 3.60 days, 6.87 +/- 0.39 days, respectively. All 12 cases of pharyngocutaneous fistula were successfully closed without additional reconstructive flap surgery. The mean time to fistula healing was 36.25 +/- 5.89 days. When the 10 patients who developed postoperative pharyngocutaneous fistula were divided into 2 groups based on whether preventive EndoVAC was performed or not, the time for improvement of the 5 patients who underwent preventive EndoVAC was 26.2 +/- 3.81 days. Whereas for 5 patients who did not, it was 43 +/- 10.33 days. EndoVAC is considered a straightforward and effective treatment for pharyngocutaneous fistula.
C1 [Lee, Joon Kyoo] Chonnam Natl Univ, Dept Otolaryngol Head & Neck Surg, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
   [Lee, Joon Kyoo] Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
C3 Chonnam National University
RP Lee, JK (通讯作者)，Chonnam Natl Univ, Dept Otolaryngol Head & Neck Surg, Med Sch, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.; Lee, JK (通讯作者)，Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea.
EM hyebin117@hanmail.net; room804@naver.com; yoontm@jnu.ac.kr;
   leen3l@jnu.ac.kr; limsc@jnu.ac.kr; joonkyoo@jnu.ac.kr
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NR 31
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1049-2275
EI 1536-3732
J9 J CRANIOFAC SURG
JI J. Craniofac. Surg.
PD MAY
PY 2026
VL 37
IS 5
BP 1213
EP 1216
DI 10.1097/SCS.0000000000011873
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI4FS
UT WOS:001754794600020
PM 40892052
DA 2026-07-24
ER

PT J
AU Serena, TE
   Buan, JS
AF Serena, Thomas E.
   Buan, John S.
TI The Use of a Novel Canister-free Negative-Pressure Device in Chronic
   Wounds A Retrospective Analysis
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; chronic wound healing; retrospective
   study
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE
AB OBJECTIVE:
   Negative-pressure wound therapy (NPWT) is a mainstay in the treatment of acute and chronic wounds. Following the success of the Vacuum-Assisted Closure system (Kinetic Concepts Inc [KCI], an Acelity Company, San Antonio, Texas), many similar systems were developed with minor variations. However, these systems are best suited to wounds with soft-tissue defects. Moreover, the need for a canister to collect wound exudate adds to the size and weight of the device. A canister-free (CF) NPWT device was cleared by the FDA for the treatment of chronic wounds (Kalypto Medical, Mendota Heights, Minnesota). A retrospective study was designed to evaluate the effectiveness of the CF-NPWT device in promoting wound healing.
   METHODS:
   The authors examined the records of 51 patients treated with the CF-NPWT device over a 21-month period. Study participants were treated in an outpatient setting, had at least 30 days of prior treatment, and carried insurance coverage through Medicare or Medicaid. The comparison of time to heal between groups was conducted using the log-rank, Breslow, and Tarone-Ware tests in conjunction with a Kaplan-Meier analysis.
   RESULTS:
   In the study population, 65% of the wounds achieved complete closure. For unhealed wounds, the mean wound area reduction was 31.9%, and the mean wound depth reduction was 57.5%. The mean time to heal was 56.9 days (95% confidence interval, 46.4-67.4 days).
   CONCLUSIONS:
   The results show that the CF-NPWT system meets or exceeds healing rates previously reported in the literature for canister-based systems. This CF device offers a more portable NPWT option, particularly effective in the treatment of shallow wounds.
C1 [Serena, Thomas E.] SerenaGroup, Cambridge, MA USA.
   [Buan, John S.] Bioadaptive LLC, St Paul, MN USA.
RP Serena, TE (通讯作者)，SerenaGroup, Cambridge, MA USA.
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
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   Wanner MB, 2003, SCAND J PLAST RECONS, V37, P28
   Yang Charlie C, 2006, J Surg Orthop Adv, V15, P19
NR 5
TC 1
Z9 1
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2016
VL 29
IS 4
BP 165
EP 168
DI 10.1097/01.ASW.0000481188.31032.52
PG 4
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DH5RH
UT WOS:000372849000001
PM 26978800
DA 2026-07-24
ER

PT J
AU Singh, D
   Chopra, K
   Sabino, J
   Brown, E
AF Singh, Devinder
   Chopra, Karan
   Sabino, Jennifer
   Brown, Emile
TI Practical Things You Should Know about Wound Healing and Vacuum-Assisted
   Closure Management
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID NEGATIVE-PRESSURE THERAPY; HYPERBARIC-OXYGEN THERAPY; CLOSED INCISION
   MANAGEMENT; INDOCYANINE GREEN; FLUORESCENCE ANGIOGRAPHY; OBESE-PATIENTS;
   DOUBLE-BLIND; INSTILLATION; COMPLICATIONS; INFECTIONS
AB Learning Objectives: After reading this article, the participant should be able to: 1. Understand the basics of negative-pressure wound therapy and practical uses of various vacuum-assisted closure dressings. 2. Understand the mechanisms of action of negative-pressure therapies and other important adjuncts, such as perfusion imaging. 3. Discuss the evidence for hyperbaric oxygen therapy in wound care.
   Summary: Wound healing requires creating an environment that supports the healing process while decreasing inflammation and infection. Negative-pressure wound therapy has changed the way physicians manage acute and chronic wounds for more than 20 years. It contracts wound edges, removes exudate, including inflammatory and infectious material, and promotes angiogenesis and granulation tissue formation. These effects have been consistently demonstrated in multiple animal and human randomized controlled trials. Recent innovations that include instillation therapy and closed incision have further increased our arsenal against difficult-to-treat wounds and incisions at high risk of complications. Instillation of topical wound solutions allows physicians to cleanse the wound without return to the operating room, resulting in fewer debridements, shorter hospital stays, and faster time to wound closure. Other concepts have yielded negative-pressure therapy on top of closed surgical incisions, which holds incision edges together, reduces edema, promotes angiogenesis, and creates a barrier to protect incisions during the critical healing period, thereby reducing surgical-site complications, especially infection. Other practical adjuncts to the modern-day treatment of acute and chronic wounds include indocyanine green angiography, which allows real-time assessment of perfusion, and hyperbaric oxygen treatment, which has been suggested to augment healing in acute, chronic, specifically diabetic foot ulcers and radiation-related wounds.
C1 [Singh, Devinder] Anne Arundel Med Ctr, Div Plast Surg, 2000 Med Pkwy,Belcher Pavil,Suite 200, Annapolis, MD 21401 USA.
   Johns Hopkins Univ Hosp, Dept Plast Surg, Baltimore, MD 21287 USA.
   Madigan Army Med Ctr, Joint Base Lewis Mcchord, WA USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Madigan Army Medical
   Center
RP Singh, D (通讯作者)，Anne Arundel Med Ctr, Div Plast Surg, 2000 Med Pkwy,Belcher Pavil,Suite 200, Annapolis, MD 21401 USA.
EM dsingh.MD@gmail.com
RI Singh, Devinder/AAN-4716-2021
CR [Anonymous], PODIATRY MANAGE
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NR 83
TC 32
Z9 40
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2020
VL 145
IS 4
BP 839E
EP 854E
DI 10.1097/PRS.0000000000006652
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LK1KX
UT WOS:000530618900020
PM 32221237
DA 2026-07-24
ER

PT J
AU Deleyto, E
   García-Ruano, A
   González-López, JR
AF Deleyto, E.
   Garcia-Ruano, A.
   Gonzalez-Lopez, J. R.
TI Negative pressure wound therapy with instillation, a cost-effective
   treatment for abdominal mesh exposure
SO HERNIA
LA English
DT Article
DE Abdominal wall; Diagnosis-related groups; Efficiency; Surgical mesh;
   Vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; SALINE INSTILLATION; DEHISCENCE; MANAGEMENT;
   REPAIR; HERNIA; ULCERS; TRIAL
AB Negative pressure wound therapy with instillation (NPWTi) has been proved to be a safe and effective treatment option for abdominal wall wound dehiscence with mesh exposure. Our aim in this study is to examine whether it is also cost-effective.
   We performed a retrospective cohort study with 45 patients treated for postoperative abdominal wall wound dehiscence and exposed mesh: 34 were treated with conventional wound therapy (CWT) and 11 with NPWTi. We carried out a cost analysis for each treatment group using the Diagnosis-related group (DRG) system and a second evaluation using the calculated costs "per hospital stay". The differences between NPWTi and CWT were calculated with both evaluation systems. Comparative analysis was performed using the Mann-Whitney U test.
   Mean costs using the DRG estimation were 29,613.71a,notsign for the CWT group and 15,093.37a,notsign for the NPWTi group, and according to the calculated expenses "per hospital stay", 17,322.88a,notsign for the CWT group and 15,284.22a,notsign for the NPWTi group. NPWTi showed a reduction in the total expense of treatment, related to a reduction in episodes of hospitalization and number of surgeries required to achieve wound closure. However, differences were not statistically significant in our sample.
   NPWTi proves to be an efficient treatment option for abdominal wall wound dehiscence with mesh exposure, compared to CWT. More trials aimed to optimize treatment protocols will lead to an additional increase in NPWTi efficiency. In addition, to generalize our results, further studies with larger samples would be necessary.
C1 [Deleyto, E.; Garcia-Ruano, A.] Univ Hosp Gregorio Maranon, Dept Plast Surg, C Dr Esquerdo 46, Madrid 28007, Spain.
   [Gonzalez-Lopez, J. R.] Univ Seville, Fac Nursing Physiotherapy & Podiatry, C Avenzoar 6, E-41009 Seville, Spain.
   [Garcia-Ruano, A.] C Gustavo Bacarisas 2,6 B, Seville 41010, Spain.
C3 General University Gregorio Maranon Hospital; University of Sevilla
RP García-Ruano, A (通讯作者)，Univ Hosp Gregorio Maranon, Dept Plast Surg, C Dr Esquerdo 46, Madrid 28007, Spain.
EM dra.angelagr@gmail.com
RI ; González-López, José Rafael/A-2269-2011
OI Deleyto, Esther/0000-0002-8289-2748; González-López, José
   Rafael/0000-0002-8962-3540
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NR 30
TC 7
Z9 11
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1265-4906
EI 1248-9204
J9 HERNIA
JI Hernia
PD APR
PY 2018
VL 22
IS 2
BP 311
EP 318
DI 10.1007/s10029-017-1691-y
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GA3SB
UT WOS:000428248700012
PM 29086171
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhang, XX
   Wan, L
   Yang, RJ
   Jin, PP
   Xia, WD
   Ye, YY
   Liu, ZJ
   Xian, J
   Li, X
   Cheng, XB
   Lin, C
AF Zhang, Xingxing
   Wan, Li
   Yang, Ruijin
   Jin, Pengpeng
   Xia, Weidong
   Ye, Yuanyuan
   Liu, Zhengjun
   Xian, Jian
   Li, Xu
   Cheng, Xingbo
   Lin, Cai
TI Expression of connective tissue growth factor and periostin of wound
   tissue in patients with diabetes who had vacuum sealing drainage
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Diabetic ulcer; connective tissue growth factor; periostin; vacuum
   sealing drainage
ID ASSISTED CLOSURE; CCN2 EXPRESSION
AB This study aimed to examine clinical effect of vacuum sealing drainage in treating the wound tissue of patients with diabetes; and investigate the expression of periostin and connective tissue growth factor in wound tissue. We selected 40 patients with diabetes and chronic ulcers, and assigned randomly into two groups: the vacuum sealing drainage group and routine dressing group (controls). Tissues were cut at day 1 before treatment and day 7 after treatment. Immunohistochemistry was used to observe periostin and connective tissue growth factor expression. Cure time and cure rate between the two groups was observed. Connective tissue growth factor and periostin were rarely expressed in wound tissue before treatment, but were increased after treatment. The mean count of periostin-positive cells was 25.2 +/- 3.50 in the vacuum sealing drainage group and 12.9 +/- 1.8 in the control group (P < 0.05). The mean count of connective tissue growth factor-positive cells was 19.7 +/- 2.54 in the vacuum sealing drainage group and 6.8 +/- 1.58 in the control group (P < 0.05). The mean duration of hospitalization of the vacuum sealing drainage group was 33.4 +/- 7.91 days, and 17 (85%) patients were cured. The mean duration of hospitalization of the routine treatment group was 50.45 +/- 6.77 days, and 13 (65%) patients were cured (both P < 0.05). This study shows that vacuum sealing drainage can shorten the healing time of diabetic chronic wounds and was addition to the mechanism of the vacuum sealing drainage treatment of diabetic wound.
C1 [Zhang, Xingxing; Cheng, Xingbo] Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, Suzhou 215006, Peoples R China.
   [Wan, Li] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou 325000, Zhejiang, Peoples R China.
   [Xia, Weidong; Ye, Yuanyuan; Liu, Zhengjun; Lin, Cai] Wenzhou Med Univ, Affiliated Hosp 1, Dept Burn & Wound Healing Ctr, Wenzhou 325000, Zhejiang, Peoples R China.
   [Jin, Pengpeng] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
   [Xian, Jian] Wenzhou Med Univ, Key Lab Biotechnol & Pharmaceut Engn, Sch Pharm, Wenzhou 325000, Zhejiang, Peoples R China.
   [Li, Xu] Wenzhou Med Univ, Dept Physiol, Renji Coll, Wenzhou 325000, Zhejiang, Peoples R China.
   [Yang, Ruijin] Sun Yat Sen Univ, Tung Wah Hosp, Dept Burns & Plast Surg, Dongguan 523000, Guangdong, Peoples R China.
   [Zhang, Xingxing] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Soochow University - China; Wenzhou Medical University; Wenzhou Medical
   University; Fudan University; Wenzhou Medical University; Wenzhou
   Medical University; Sun Yat Sen University; Wenzhou Medical University
RP Cheng, XB (通讯作者)，Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, Suzhou 215006, Peoples R China.; Lin, C (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 1, Dept Burn & Wound Healing Ctr, Wenzhou 325000, Zhejiang, Peoples R China.
EM Xingbo1107@sohu.com; lincai_0577@163.com
RI Xian, Jianzhong/HCI-4011-2022
FU Action Planning for Major disease prevention science and technology of
   Development Center for Medical Science and Technology National Health
   and Family Planning Commission of the People's Republic of China
   [ZX-01-C2015041]; Science and Technology Program of Wenzhou [Y20150273,
   Y20130166, Y20140-187]; Education Department of Zhejiang Province
   [Y201431185]
FX This work was supported by The Action Planning for Major disease
   prevention science and technology of Development Center for Medical
   Science and Technology National Health and Family Planning Commission of
   the People's Republic of China (ZX-01-C2015041, Science and Technology
   Program of Wenzhou (Grant No. Y20150273, Y20130166, and Y20140-187), and
   Education Department of Zhejiang Province (No. Y201431185).
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NR 24
TC 6
Z9 6
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 8
BP 12942
EP 12950
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FZ6PT
UT WOS:000427722200001
DA 2026-07-24
ER

PT J
AU Trevino, CM
   Verhaalen, A
   Bruce, ML
   Webb, T
AF Trevino, Colleen M.
   Verhaalen, Amy
   Bruce, Marie L.
   Webb, Travis
TI Conversion of an Enterocutaneous Fistula Associated With an Open
   Abdominal Wound Into a Drain-Controlled Enterocutaneous Fistula
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE enterocutaneous fistula; cutaneous fistula; fistula isolation
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Open abdominal wounds with enterocutaneous fistulae present health care providers and patients with complex wound management issues. Frequently, large wounds with exposed bowel are present and require the utilization of multiple wound care modalities to provide a method of control and isolation of fistula effluent to allow for maximum wound healing. This case study presents a unique approach to management of low-output enterocutaneous fistula with an open abdominal wound. Through the use of negative pressure wound therapy, a standard surgical drain, and optimized nutrition, fistula drainage was redirected and the abdominal wound healed, leaving a drain-controlled enterocutaneous fistula.
C1 [Trevino, Colleen M.; Verhaalen, Amy; Bruce, Marie L.; Webb, Travis] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Trevino, CM (通讯作者)，Med Coll Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM ctrevino@mcw.edu
OI Trevino, Colleen/0000-0002-7813-3642
CR European Wound Management Association, 2007, POS DOC TOP NEG PRES
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Ichioka S, 2008, WOUND REPAIR REGEN, V16, P460, DOI 10.1111/j.1524-475X.2008.00390.x
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Schecter WP, 2006, J AM COLL SURGEONS, V203, P390, DOI 10.1016/j.jamcollsurg.2006.06.001
   Schecter WP, 2009, J AM COLL SURGEONS, V209, P484, DOI 10.1016/j.jamcollsurg.2009.05.025
   Verhaalen AL, 2006, GEN SURG NEWS, V33
NR 7
TC 1
Z9 2
U1 1
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2014
VL 26
IS 2
BP 43
EP 46
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AB6VL
UT WOS:000331927500003
PM 25860225
DA 2026-07-24
ER

PT J
AU Osada, H
   Nakajima, H
   Morishima, M
   Su, T
AF Osada, Hiroaki
   Nakajima, Hiroyuki
   Morishima, Manabu
   Su, Takamitsu
TI Candidal mediastinitis successfully treated using vacuum-assisted
   closure following open-heart surgery
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Antibiotics; Mediastinal infection; Postoperative care; Candidal
   infection; Surgical site infection
ID STERNAL WOUND-INFECTION; POST-STERNOTOMY MEDIASTINITIS; LONG-TERM
   SURVIVAL; THERAPY
AB Deep sternal wound infections (DSWIs) are an uncommon but serious complication after open-heart surgery. The reported incidence of DSWIs due to Candida albicans is 0.4%, but these infections have an extremely high mortality of 56%. We herein report a rare case of a 79-year old woman who suffered from Candidal DSWI after repeated open-heart surgeries. We treated her with negative pressure wound therapy (NPWT). This is the rare case report that provides evidence that NPWT is a safe and suitable technique for the management of Candidal DSWIs.
C1 [Osada, Hiroaki] Mitsubishi Kyoto Hosp, Dept Cardiovasc Surg, Nishikyo Ku, Kyoto 6158087, Japan.
RP Osada, H (通讯作者)，Mitsubishi Kyoto Hosp, Dept Cardiovasc Surg, Nishikyo Ku, 1 Katsuragoshomachi, Kyoto 6158087, Japan.
EM osahiro@kuhp.kyoto-u.ac.jp
RI /HPF-4944-2023
CR Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Clancy CJ, 1997, CLIN INFECT DIS, V25, P608, DOI 10.1086/513770
   Gustafsson RI, 2003, ANN THORAC SURG, V76, P2048, DOI 10.1016/S0003-4975(03)01337-7
   Malani PN, 2002, CLIN INFECT DIS, V35, P1316, DOI 10.1086/344192
   Modrau IS, 2009, ANN THORAC SURG, V88, P1905, DOI 10.1016/j.athoracsur.2009.08.012
   Petzina R, 2010, EUR J CARDIO-THORAC, V38, P110, DOI 10.1016/j.ejcts.2010.01.028
   Risnes I, 2010, ANN THORAC SURG, V89, P1502, DOI 10.1016/j.athoracsur.2010.02.038
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Tocco MP, 2009, EUR J CARDIO-THORAC, V35, P833, DOI 10.1016/j.ejcts.2008.12.036
NR 9
TC 7
Z9 9
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD JUN
PY 2012
VL 14
IS 6
BP 872
EP 874
DI 10.1093/icvts/ivs084
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 025GK
UT WOS:000310175300052
PM 22422875
OA Bronze
DA 2026-07-24
ER

PT J
AU Datiashvili, RO
   Knox, KR
AF Datiashvili, RO
   Knox, KR
TI Negative pressure dressings: An alternative to free tissue transfers?
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; SUBATMOSPHERIC PRESSURE; FREE
   FLAPS; THERAPY; EXPERIENCE; WOUNDS; FATE
AB Free tissue transfer is a well established tool for the reconstruction of large, complicated wounds of the extremities. However, when free flap reconstruction is contraindicated or in cases where it has failed, the management of this type of wound presents a formidable task. Although negative pressure wound therapy (NPWT) plays an increasing role in the treatment of complex open wounds, there are only a few reports of successful management of wounds with areas of exposed tendon or bone. The authors present their experience with the use of NPWT in, the treatment of open wounds of the extremities with relatively large areas of exposed bone.
C1 Univ Med & Dent New Jersey, Div Plast Surg, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Datiashvili, RO (通讯作者)，Univ Med & Dent New Jersey, Div Plast Surg, 90 Bergen St,Suite 7200, Newark, NJ 07103 USA.
EM datiasro@umdnj.edu
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NR 16
TC 7
Z9 12
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2005
VL 17
IS 8
BP 206
EP 212
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 960HJ
UT WOS:000231580900005
DA 2026-07-24
ER

PT J
AU Hamaguchi, R
   Shekar, PS
   Johnson, JA
   Orgill, DP
AF Hamaguchi, Ryoko
   Shekar, Prem S.
   Johnson, Jennifer A.
   Orgill, Dennis P.
TI Current Management of Sternal Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEQUENTIAL LUNG TRANSPLANTATION;
   POST-STERNOTOMY MEDIASTINITIS; GENTAMICIN-COLLAGEN SPONGE; INTERNAL
   MAMMARY ARTERY; TIGHT GLYCEMIC CONTROL; BYPASS GRAFT-SURGERY;
   OPEN-HEART-SURGERY; HIGH-RISK PATIENTS; NEGATIVE-PRESSURE
AB Learning Objectives: After studying this article, the participant should be able to: 1. Describe the pathogenesis, classification, and risk factors of sternal wound infection. 2. Discuss options for sternal stabilization for the prevention of sternal wound infection, including wiring and plating techniques. 3. Discuss primary surgical reconstructive options for deep sternal wound infection and the use of adjunctive methods, such as negative-pressure wound therapy.
   Summary: Poststernotomy sternal wound infection remains a life-threatening complication of open cardiac surgery. Successful treatment relies on timely diagnosis and initiation of multidisciplinary, multimodal therapy.
C1 [Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Div Cardiac Surg, Boston, MA 02115 USA.
   Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@bwh.harvard.edu
RI Orgill, Dennis/H-7596-2019
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NR 77
TC 12
Z9 15
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2021
VL 148
IS 6
BP 1012E
EP 1025E
DI 10.1097/PRS.0000000000008510
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XF1FU
UT WOS:000723823800014
PM 34847131
DA 2026-07-24
ER

PT J
AU Martindell, D
AF Martindell, Denise
TI The Safe Use of Negative-Pressure Wound Therapy
SO AMERICAN JOURNAL OF NURSING
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DEVICES
AB The Pennsylvania Patient Safety Reporting System is a confidential, statewide Internet reporting system to which all Pennsylvania hospitals, outpatient-surgery facilities, and birthing centers, as well as some abortion facilities, must file information on medical errors. Safety Monitor is a column from Pennsylvania's Patient Safety Authority, the authority that informs nurses on issues that can affect patient safety and presents strategies they can easily integrate into practice. For more information on the authority, visit www.patientsafetyauthority.org. For the original article discussed in this column or for other articles on patient safety, click on "Patient Safety Advisories" and then "Advisory Library" in the left-hand navigation menu.
C1 ECRI Inst, Plymouth Meeting, PA USA.
RP Martindell, D (通讯作者)，ECRI Inst, Plymouth Meeting, PA USA.
EM dmartindell@ecri.org
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NR 18
TC 6
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0002-936X
EI 1538-7488
J9 AM J NURS
JI Am. J. Nurs.
PD JUN
PY 2012
VL 112
IS 6
BP 59
EP 63
DI 10.1097/01.NAJ.0000415134.85429.9d
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 948TQ
UT WOS:000304525900025
PM 22627354
DA 2026-07-24
ER

PT J
AU Gudbjartsson, T
   Jeppsson, A
   Sjögren, J
   Steingrimsson, S
   Geirsson, A
   Friberg, O
   Dunning, J
AF Gudbjartsson, Tomas
   Jeppsson, Anders
   Sjogren, Johan
   Steingrimsson, Steinn
   Geirsson, Arnar
   Friberg, Orjan
   Dunning, Joel
TI Sternal wound infections following open heart surgery - a review
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Review
DE Cardiac surgery; prognosis; risk factors; surgical site infections;
   treatment
ID VACUUM-ASSISTED CLOSURE; TRICLOSAN-COATED SUTURES; SURGICAL SITE
   INFECTION; POST-STERNOTOMY MEDIASTINITIS; DIFFERENT NEGATIVE PRESSURES;
   RANDOMIZED CONTROLLED-TRIAL; GENTAMICIN-COLLAGEN SPONGE;
   CARDIAC-SURGERY; MEDIAN STERNOTOMY; POSTSTERNOTOMY MEDIASTINITIS
AB Surgical site infections (SSIs) are common complications after open heart surgery. Fortunately, most are superficial and respond to minor wound debridement and antibiotics. However, 1-3% of patients develop deep sternal wound infections that can be fatal. Late infections with sternocutaneous fistulas, are encountered less often, but represent a complex surgical problem. This evidence-based review covers etiology, risk factors, prevention and treatment of sternal SSIs following open heart surgery with special focus on advances in treatment, especially negative-pressure wound therapy.
C1 [Gudbjartsson, Tomas; Steingrimsson, Steinn; Geirsson, Arnar] Univ Iceland, Landspitali Univ Hosp, Dept Cardiothorac Surg, Fac Med, Reykjavik, Iceland.
   [Jeppsson, Anders] Sahlgrens Univ Hosp, Dept Cardiothorac Surg, Gothenburg, Sweden.
   [Sjogren, Johan] Skane Univ Hosp, Dept Cardiothorac Surg, Lund, Sweden.
   [Friberg, Orjan] Orebro Univ Hosp, Dept Cardiothorac Surg, Orebro, Sweden.
   [Dunning, Joel] James Cook Univ Hosp, Dept Cardiothorac Surg, Middlesbrough, Cleveland, England.
C3 University of Iceland; Landspitali National University Hospital;
   Sahlgrenska University Hospital; Lund University; Skane University
   Hospital; Orebro University; James Cook University Hospital
RP Gudbjartsson, T (通讯作者)，Univ Iceland, Landspitali Univ Hosp, Dept Cardiothorac Surg, Fac Med, Reykjavik, Iceland.; Gudbjartsson, T (通讯作者)，CONTACT Tomas Gudbjartsson, Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Sjögren, Johan/AAZ-6448-2021; Friberg, Örjan/AAQ-8685-2020;
   Steingrimsson, Steinn/AAF-5475-2021; Geirsson, Arnar/S-4735-2019
OI Friberg, Örjan/0000-0003-2708-1376; Steingrimsson,
   Steinn/0000-0001-8320-5607; 
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NR 68
TC 41
Z9 46
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2016
VL 50
IS 5-6
BP 341
EP 348
DI 10.1080/14017431.2016.1180427
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EF1SS
UT WOS:000390105700015
PM 27102109
DA 2026-07-24
ER

PT J
AU Woo, KY
   Sibbald, RG
AF Woo, Kevin Y.
   Sibbald, R. Gary
TI Vacuum-assisted closure home care training: a process to link education
   to improved patient outcomes
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
ID PRESSURE WOUND THERAPY; DIABETIC FOOT ULCERS; MULTICENTER; DEBRIDEMENT;
   INHIBITOR; BEHAVIOR; TRIAL
AB Negative pressure wound therapy (NPWT) applies subatmospheric pressure across the wound bed inducing cellular and molecular changes that are beneficial to wound healing. This healing modality may facilitate tissue debridement, infection/inflammation control, and moisture balance; the key components of the wound bed preparation paradigm. To ensure that scientific evidence is diffused into daily clinical practice, we are proposing a knowledge transfer model that articulates an educational plan for the various levels of professional development. The discussion highlights the challenges and potential solutions to integrate NPWT into a seamless continuum of care including a community-based patient care model.
C1 [Woo, Kevin Y.; Sibbald, R. Gary] Womens Coll Hosp, Wound Healing Clin, Toronto, ON M5S 1B2, Canada.
   [Sibbald, R. Gary] Univ Toronto, Dept Publ Hlth Sci & Med, Toronto, ON, Canada.
C3 University of Toronto; Womens College Hospital; University of Toronto
RP Woo, KY (通讯作者)，Womens Coll Hosp, Wound Healing Clin, 76 Grenville St, Toronto, ON M5S 1B2, Canada.
EM kevin.woo@wchospital.ca
OI Sibbald, R Gary/0000-0002-6060-7272
FU Canadian Association of Wound Care; Coloplast; Smith and Nephew; 3M;
   KCI; Molnlycke; Covidien; Johnson Johnson
FX Kevin Woo was and is a Consultant/Advisor for Coloplast, Molnlycke, KCI,
   the Registered Nurses Association of Ontario and Merck. He is a member
   of the Speaker's Bureau for Johnson & Johnson, Coloplast and Molnlycke.
   Has and is receiving grant/research funding from the Canadian
   Association of Wound Care. R. Gary Sibbald is a Consultant/Advisor, a
   member of the Speaker's bureau and has and is receiving grant/research
   funding from Coloplast, Smith and Nephew, 3M, KCI, Molnlycke, Covidien
   and Johnson & Johnson.
CR Akbari A, 2007, J REHABIL RES DEV, V44, P631, DOI 10.1682/JRRD.2007.01.0002
   Andros G, 2006, OSTOMY WOUND MANAG, P1
   [Anonymous], CHRONIC WOUND CARE C
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NR 41
TC 55
Z9 57
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2008
VL 5
SU 2
BP 1
EP 9
DI 10.1111/j.1742-481X.2008.00474.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AX
UT WOS:000207843600002
PM 17894663
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Sagi, HC
   Patzakis, MJ
AF Sagi, H. Claude
   Patzakis, Michael J.
TI Evolution in the Acute Management of Open Fracture Treatment? Part 2
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE open fracture; irrigation and debridement; irrigation solutions; timing
   to wound coverage; negative pressure wound therapy; antibiotic beads
ID PRESSURE PULSATILE LAVAGE; OPEN TIBIAL FRACTURES; TOPICAL ANTIMICROBIAL
   AGENTS; LOCAL ANTIBIOTIC DELIVERY; VACUUM-ASSISTED CLOSURE; PRIMARY
   WOUND CLOSURE; DEEP-INFECTION; CANCELLOUS BONE; OPERATIVE DEBRIDEMENT;
   SURGICAL DEBRIDEMENT
AB Introduction: In the first installment of this two-part series, we explored the history of open fracture treatment focusing primarily on bacteriology and antibiotic selection/stewardship. In this follow-up segment, we will analyze and summarize the other aspects of open fracture care such as time to debridement, pulsatile lavage, and open wound management (including time to closure)-finishing with summative statements and recommendations based on the current most up-to-date literature.
C1 [Sagi, H. Claude] Univ Cincinnati, Med Ctr, Dept Orthopaed Surg & Sports Med, Cincinnati, OH 45267 USA.
   [Patzakis, Michael J.] Univ Southern Calif, Keck Med Ctr, Dept Orthopaed Surg, Los Angeles, CA 90007 USA.
C3 University System of Ohio; University of Cincinnati; University of
   Southern California
RP Sagi, HC (通讯作者)，Univ Cincinnati, Div Trauma, Dept Orthopaed Surg & Sports Med, Coll Med, 231 Albert Sabin Way,POB 670212, Cincinnati, OH 45267 USA.
EM sagihc@ucmail.uc.edu; orthopod@hsc.usc.edu
OI Sagi, Henry Claude/0000-0002-0365-6043
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NR 80
TC 5
Z9 10
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2021
VL 35
IS 9
BP 457
EP 464
DI 10.1097/BOT.0000000000002095
PG 8
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA WN5DN
UT WOS:000711788200011
PM 34415870
DA 2026-07-24
ER

PT J
AU Dumville, JC
   Hinchliffe, RJ
   Cullum, N
   Game, F
   Stubbs, N
   Sweeting, M
   Peinemann, F
AF Dumville, Jo C.
   Hinchliffe, Robert J.
   Cullum, Nicky
   Game, Fran
   Stubbs, Nikki
   Sweeting, Michael
   Peinemann, Frank
TI Negative pressure wound therapy for treating foot wounds in people with
   diabetes mellitus
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID VACUUM-ASSISTED-CLOSURE; QUALITY-OF-LIFE; LOWER-EXTREMITY ULCERS;
   CLASSIFICATION-SYSTEM; MANAGEMENT; AMPUTATION; MULTICENTER; DEBRIDEMENT;
   PREVENTION; GUIDELINES
AB Background
   Foot wounds in people with diabetes mellitus (DM) are a common and serious global health issue. Negative pressure wound therapy can be used to treat these wounds and a clear and current overview of current evidence is required to facilitate decision-making regarding its use.
   Objectives
   To assess the effects of negative pressure wound therapy compared with standard care or other adjuvant therapies in the healing of foot wounds in people with DM.
   Search methods
   In July 2013, we searched the following databases to identify reports of relevant randomised controlled trials (RCTs): Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL); The Database of Abstracts of Reviews of Effects (DARE); The NHS Economic Evaluation Database; OvidMEDLINE; OvidMEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL.
   Selection criteria
   Published or unpublished RCTs that evaluate the effects of any brand of negative pressure wound therapy in the treatment of foot wounds in people with diabetes, irrespective of publication date or language of publication. Particular effort was made to identify unpublished studies.
   Data collection and analysis
   Two review authors independently performed study selection, risk of bias assessment and data extraction.
   Main results
   We included five studies in this review randomising 605 participants. Two studies (total of 502 participants) compared negative pressure wound therapy with standard moist wound dressings. The first of these was conducted in people with DM and post-amputation wounds and reported that significantly more people healed in the negative pressure wound therapy group compared with the moist dressing group: (risk ratio 1.44; 95% CI 1.03 to 2.01). The second study, conducted in people with debrided foot ulcers, also reported a statistically significant increase in the proportion of ulcers healed in the negative pressure wound therapy group compared with the moist dressing group: (risk ratio 1.49; 95% CI 1.11 to 2.01). However, these studies were noted to be at risk of performance bias, so caution is required in their interpretation. Findings from the remaining three studies provided limited data, as they were small, with limited reporting, as well as being at unclear risk of bias.
   Authors' conclusions
   There is some evidence to suggest that negative pressure wound therapy is more effective in healing post-operative foot wounds and ulcers of the foot in people with DM compared with moist wound dressings. However, these findings are uncertain due to the possible risk of bias in the original studies. The limitations in current RCT evidence suggests that further trials are required to reduce uncertainty around decision making regarding the use of NPWT to treat foot wounds in people with DM.
C1 [Dumville, Jo C.] Univ Manchester, Dept Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Hinchliffe, Robert J.] St Georges Healthcare NHS Trust, St Georges Vasc Inst, London, England.
   [Cullum, Nicky] Univ Manchester, Sch Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
   [Game, Fran] Derby Hosp NHS Fdn Trust, Dept Endocrinol & Diabet, Derby, England.
   [Stubbs, Nikki] Leeds Community Hlth Care NHS Trust, St Marys Hosp, Leeds, W Yorkshire, England.
   [Sweeting, Michael] MRC, Biostat Unit, Inst Publ Hlth, Cambridge CB2 2BW, England.
   [Peinemann, Frank] Univ Cologne, Childrens Hosp, D-50931 Cologne, Germany.
C3 University of Manchester; City St Georges, University of London;
   University of Manchester; University of Cambridge; MRC Biostatistics
   Unit; University of Cologne
RP Dumville, JC (通讯作者)，Univ Manchester, Dept Nursing Midwifery & Social Work, Manchester M13 9PL, Lancs, England.
EM jo.dumville@manchester.ac.uk
RI /H-2800-2019; Cullum, Nicky/F-2438-2011; Sweeting, Michael/U-3917-2019;
   Dumville, Jo/O-7867-2014
OI Cullum, Nicky/0000-0003-2631-123X; Game, Frances/0000-0002-5294-4789;
   Sweeting, Michael/0000-0003-0980-8965; Dumville, Jo/0000-0002-6546-3685
FU Department of Health Sciences, University of York, UK; NIHR/Department
   of Health (England), (Cochrane Wounds Group), UK; NIHR Programme Grants
   for Applied Research, UK; National Institute for Health Research
   [RP-PG-0407-10428, NF-SI-0512-10028] Funding Source: researchfish
FX Internal sources Department of Health Sciences, University of York, UK.
   External sources NIHR/Department of Health (England), (Cochrane Wounds
   Group), UK. NIHR Programme Grants for Applied Research, UK.
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NR 88
TC 84
Z9 95
U1 1
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 10
AR CD010318
DI 10.1002/14651858.CD010318.pub2
PG 50
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 244FT
UT WOS:000326373200041
PM 24132761
DA 2026-07-24
ER

PT J
AU Li, ZQ
   Wu, WJ
   Liu, SJ
   Hao, YS
AF Li, Zhiqiang
   Wu, Wenjie
   Liu, Shujiang
   Hao, Yusheng
TI Effect of vacuum sealing drainage in dermatoplasty of large area of
   cutaneous defects
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Vacuum sealing drainage; Dermatoplasty; Cutaneous defects
ID PRESSURE WOUND THERAPY; SKIN; EXPERIENCE; DEEP
AB Objectives: To investigate the clinical effect of vacuum sealing drainage in dermatoplasty of large area of cutaneous defects in comparison to conventional treatment.
   Methods: 80 patients with large area of cutaneous defects were enrolled in this study, and they had received superficial thickness dermatoplasty. Then these patients were randomly divided into two groups based on follow-up treatments: vacuum sealing drainage (defined as group A, 40 cases) and conventional treatment (defined as group B, 40 cases). After operation, all the patients received similar hospital stay, antibiotics administration, swelling elimination and wound closure in these two groups.
   Results: No significant difference was observed in terms of the baseline characteristics between the two groups, including areas of cutaneous defects. Compared with conventional treatment group, the healing time of dermatoplasty was reduced significantly in vacuum sealing drainage group. Meanwhile, the rate of survival of dermatoplasty was better, and the rate of wound infection was lower in vacuum sealing drainage group than conventional treatment group.
   Conclusion: Vacuum sealing drainage is effective in treatment with large area of cutaneous defects combined with dermatoplasty, which had better clinical outcomes than conventional therapy. (C) 2017 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.
C1 [Li, Zhiqiang; Wu, Wenjie; Liu, Shujiang; Hao, Yusheng] Peoples Hosp Cangzhou, Dept Orthoped, Cangzhou 061000, Peoples R China.
RP Hao, YS (通讯作者)，Peoples Hosp Cangzhou, Dept Orthoped, Cangzhou 061000, Peoples R China.
EM haoyushenhb@163.com
FU cience and technology research and development plan of Cangzhou
   [131302084]
FX This research was supported by Science and technology research and
   development plan of Cangzhou (Grant No. 131302084).
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NR 24
TC 23
Z9 32
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JUN
PY 2017
VL 42
BP 143
EP 146
DI 10.1016/j.ijsu.2017.04.059
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FA5AX
UT WOS:000405456100023
PM 28478317
DA 2026-07-24
ER

PT J
AU Malmsjö, M
   Lindstedt, S
   Ingemansson, R
AF Malmsjo, Malin
   Lindstedt, Sandra
   Ingemansson, Richard
TI Effects of foam or gauze on sternum wound contraction, distension and
   heart and lung damage during negative-pressure wound therapy of porcine
   sternotomy wounds
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Animal model; Wound contraction; Experimental surgery; Heart rupture;
   Negative-pressure wound therapy; Sternotomy wound
ID VACUUM-ASSISTED CLOSURE; VENTRICULAR RUPTURE; TRANSDUCTION
AB The study was performed to compare the effects of negative-pressure wound therapy (NPWT) using gauze and foam on wound edge movement and the macroscopic appearance of the heart and lungs after NPWT. Sternotomy wounds were created in 6x70 kg pigs. Negative pressures of -40, -70, -120 and -160 mmHg were applied and the following were evaluated: wound contraction, distension and the macroscopic appearance of the heart and lungs after NPWT. Wound contraction was greater when using foam than gauze (3.5+/-0.3 cm and 1.3+/-0.2 cm, respectively, P<0.01). The application of traction to the lateral edges of the sternotomy resulted in greater wound distention with foam than with gauze (5.3+/-0.3 cm and 3.6+/-0.2 cm, respectively, P<0.001). After using foam, the surface of the heart was red and mottled, and lung emphysema and sometimes, lung rupture were observed. After using gauze, the organ surface had no markings. The study shows that foam allows greater wound contraction and distension than gauze. This movement of the wound edges may cause damage to the underlying organs. There is less damage to the heart and lungs when using gauze than foam. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
FU Ake-Wieberg Foundation; Magn Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Crafoord Foundation;
   Swedish Heart-Lung Foundation; Swedish Hypertension Society; Smith &
   Nephew Wound Management
FX This study was funded by the Ake-Wieberg Foundation, the Magn Bergvall
   Foundation, the Swedish Medical Association, the Royal Physiographic
   Society in Lund, the Crafoord Foundation, the Swedish Heart-Lung
   Foundation, the Swedish Hypertension Society and Smith & Nephew Wound
   Management.
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NR 15
TC 10
Z9 13
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAR
PY 2011
VL 12
IS 3
BP 349
EP 354
DI 10.1510/icvts.2010.249078
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022VM
UT WOS:000309991900003
PM 21186283
OA Bronze
DA 2026-07-24
ER

PT J
AU Aljomah, AS
   Hammami, MM
AF Aljomah, Ahmed S.
   Hammami, Muhammad M.
TI Circumferential Negative Intermittent Pressure to the Midarm Does Not
   Impair Digital O2 Saturation A Randomized Controlled Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE NPWT; negative pressure wound therapy; wound healing; wound management;
   pressure; negative pressure dressings; topical negative pressure
   therapy; vacuum-assisted closure; negative pressure wound therapy;
   negative pressure; VAC; vacuum-assisted closure; wounds
ID WOUND THERAPY
AB Background Circumferential negative pressure wound therapy is commonly used to manage wounds and enhance the healing process. A theoretical concern was recently raised that circumferential negative pressure wound therapy may have a negative effect on perfusion distally. Methods In a randomized study, we applied circumferential negative pressure (125 mm Hg) to the midarm of 13 healthy volunteers through InfoV.A.C. Therapy Unit device. The pressure was applied intermittently (5 minutes on and 2 minutes off) for 9 hours. The same device without negative pressure was applied to the contralateral midarm as control. Bilateral index finger O-2 saturation (Spo(2)) was measured every 30 minutes using digital pulse oximetry. Results Mean (SD) age of the volunteers was 32.2 (9.5) years, and 61.5% were male. Mean (SD) area under the curve from time 0 to 9 hours of Spo(2) was 890.56 (6.69) and 889.71 (6.23) %xh in the intervention and control arms, respectively (P = 0.35). O-2 saturation was >= 94% at all observation times in both arms, and no adverse events were identified. Conclusions Circumferential negative intermittent pressure of 125 mm Hg applied to the midarm of healthy volunteers for 9 hours does not adversely affect digital Spo(2).
C1 [Aljomah, Ahmed S.; Hammami, Muhammad M.] King Faisal Specialist Hosp & Res Ctr, Clin Studies & Empir Ethics Dept, POB 3354,MBC03, Riyadh 11211, Saudi Arabia.
   [Hammami, Muhammad M.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center; Alfaisal University
RP Hammami, MM (通讯作者)，King Faisal Specialist Hosp & Res Ctr, Clin Studies & Empir Ethics Dept, POB 3354,MBC03, Riyadh 11211, Saudi Arabia.
EM Muhammad@kfshrc.edu.sa
RI Hammami, Muhammad/B-2405-2019
OI Hammami, Muhammad/0000-0002-0086-5819
FU Department of Clinical Studies and Empirical Ethics, King Faisal
   Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
FX None of the authors have a financial interest in any of the products or
   devices mentioned in this article. This study was completely funded by
   the Department of Clinical Studies and Empirical Ethics, King Faisal
   Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. InfoV.A.
   C. Therapy Unit device (KCI USA, Inc, San Antonio, Texas) was used for
   negative pressure, and Vital Signs Monitor (CASMED 740 vital signs
   monitor; CAS Medical Systems, Branford, Connecticut) used for measuring
   of O<INF>2</INF> saturation.
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Othman Diaa, 2012, Plast Surg Int, V2012, P374398, DOI 10.1155/2012/374398
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NR 7
TC 5
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD FEB
PY 2020
VL 84
IS 2
BP E7
EP E9
DI 10.1097/SAP.0000000000001966
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KE2IQ
UT WOS:000508382300002
PM 31490239
DA 2026-07-24
ER

PT J
AU Nolff, MC
   Albert, R
   Reese, S
   Meyer-Lindenberg, A
AF Nolff, Mirja C.
   Albert, Rebecca
   Reese, Sven
   Meyer-Lindenberg, Andrea
TI Comparison of Negative Pressure Wound Therapy and Silver-Coated Foam
   Dressings in Open Wound Treatment in Dogs: A Prospective Controlled
   Clinical Trial
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE negative pressure wound therapy; polyurethane foam; wound bioburden;
   open wound management; wound; wound planimetry; dog
ID VACUUM-ASSISTED CLOSURE; BLOOD-FLOW; MANAGEMENT; CAT; RECONSTRUCTION;
   PROLIFERATION; GRANULATION; BANDAGES; SKIN; WALL
AB Objectives To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.
   Study Type Prospective randomized clinical study
   Materials and Methods Dogs (n = 26) undergoing open-wound treatment were randomly assigned to one of two groups: Group A (n = 13) NPWT; Group B (n = 13) silver-coated foam dressing. Pairs of patients were matched based on wound conformation, localization, and underlying cause and compared in terms of duration of previous treatment, development of wound size (wound planimetry), time to closure, bacterial bio-burden and complications. Wound dressing changes were performed every 3 days during the first 9 days of therapy for both groups. Statistical analysis was performed.
   Results Pre-treatment signalment and bacterial status were comparable between groups. Total time to closure was significantly (p = 0.018) shorter in Group A (14.2 days) compared with Group B (28.6 days), and wound planimetry on days 3, 6 and 9 showed significant greater reduction in total wound area for Group A at all-time points (p < 0.05). Furthermore, wounds in Group A showed less progression of local infection than did wounds in Group B (p = 0.01).
   Conclusion NPWT-treated wounds showed faster closure, improved macro-deformation and less local signs of infection.
C1 [Nolff, Mirja C.; Albert, Rebecca; Meyer-Lindenberg, Andrea] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Dept Clin Vet Med, Munich, Bayern, Germany.
   [Reese, Sven] Ludwig Maximilians Univ Munchen, Dept Basic Vet Sci, Munich, Bayern, Germany.
C3 University of Munich; University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Bayern, Germany.
EM m.nolff@lmu.de
RI Nolff, Mirja/W-6756-2019; Reese, Sven/F-1826-2016; Meyer-Lindenberg,
   Andreas/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; Reese, Sven/0000-0002-4605-9791; 
FU Gesellschaft zur Forderung Kynologischer Forschung e.V.
FX The study was partly funded by the 'Gesellschaft zur Forderung
   Kynologischer Forschung e.V'.
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NR 50
TC 14
Z9 19
U1 1
U2 20
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PD JUL
PY 2018
VL 31
IS 4
BP 229
EP 238
DI 10.1055/s-0038-1639579
PG 10
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA GO5BC
UT WOS:000440031700002
PM 29890536
DA 2026-07-24
ER

PT J
AU Shweiki, E
   Gallagher, KE
AF Shweiki, Ehyal
   Gallagher, Kathy E.
TI Assessing a Safe Interval for Subsequent Negative Pressure Wound Therapy
   Change After Initial Placement in Acute, Contaminated Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; contamination; dressing changes
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; MANAGEMENT; INFECTIONS;
   DRESSINGS; DEFINITIONS; EXPERIENCE; SEPSIS; SYSTEM; TRIAL
AB Background. Negative pressure wound therapy (NPWT) is empirically expanding across the globe. Yet published data with NPWT in acute, contaminated wounds is limited, and several concerns arise regarding contemporary acute wound care NPWT practice. Specifically, there are no evidence-based time intervals Specifying when NPWT should be changed after initial placement in such Cases; therefore, NPWT was studied in acute, contaminated wounds. Methods. The authors retrospectively reviewed 86 consecutive patients, and a total of 97 contaminated wounds. All wounds were class IV, based on Centers for Disease Control and Prevention (CDC) criteria. All patients were managed with NPWT. Patient and wound-specific variables were analyzed. Outcome endpoints included durability of wound closure and death: Results. Mean time of subsequent NPWT after initial placement was 2.9 days, median time 3 days, mode 2 days, and standard deviation (SD) 1.24 days. Durability of wound closure was 73/79 (92%). Deaths were noted in 6/86 (7%) of patients. No deaths appeared related to NPWT. Conclusions. Based on the findings in this study, analyzing NPWT in the largest known patient cohort of this type, a time interval of 1.7 days to 4.1 days (mean time 2.9 days, SD 1.24), between initial and subsequent placement of NPWT in acute, contaminated wounds is safe and effective.
C1 [Shweiki, Ehyal] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA.
   [Gallagher, Kathy E.] Christiana Care Hlth Syst, Newark, DE 19713 USA.
C3 Thomas Jefferson University; Christiana Care Health System
RP Gallagher, KE (通讯作者)，Christiana Care Hlth Syst, Surg Crit Care, MAP 2,Suite 3301,4735 Ogletown Stanton Rd, Newark, DE 19713 USA.
EM kagallagher@christianacare.org
CR [Anonymous], MOR SEC WORLD OUR SH
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NR 40
TC 3
Z9 3
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2013
VL 25
IS 9
BP 263
EP 271
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 225MB
UT WOS:000324965900006
PM 25867242
DA 2026-07-24
ER

PT J
AU Dunn, R
   Hurd, T
   Chadwick, P
   Cote, J
   Cockwill, J
   Mole, T
   Smith, J
AF Dunn, Raymond
   Hurd, Theresa
   Chadwick, P.
   Cote, Julien
   Cockwill, John
   Mole, Trevor
   Smith, Jennifer
TI Factors associated with positive outcomes in 131 patients treated with
   gauze-based negative pressure wound therapy
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy; Gauze-based NPWT; Wound dimensions;
   Goals of NPWT
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; BRIDGE
AB Negative Pressure Wound Therapy (NPWT) is commonly used in many surgical specialties to improve wound management and healing outcomes. This study reports the ability of gauze-based NPWT to address several treatment goals commonly defined at the onset of therapy. A prospective, multi-center, non-comparative clinical investigation was carried out using gauze-based NPWT in chronic and acute wounds. 131 patients including traumatic, post-surgical and chronic wounds were assessed. Weekly percentage reductions in wound area, depth and volume were 8.3%, 15.8% and 20.5% respectively (p < 0.001). A reduction in exudate level was observed from baseline to treatment discontinuation (p < 0.001). An increase (p = 0.007) in red granulation tissue and a decrease (p < 0.001) in non-viable tissue was observed. Baseline wound characteristics associated with slower rates of progress included chronic wound aetiologies, longer wound duration prior to NPWT and presence of diabetes as a comorbidity. Important indicators of wounds which had improved sufficiently and no longer required NPWT included reduction in volume and exudate levels. Gauze-based NPWT can be used to address many of the treatment goals commonly defined at the onset of therapy including reduction in wound volume, management of exudate and infection status, and improvement in wound bed quality. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Mole, Trevor; Smith, Jennifer] Smith & Nephew Wound Management, Kingston Upon Hull HU32BN, N Humberside, England.
   [Cockwill, John] Smith & Nephew Wound Management Inc, St Petersburg, FL USA.
   [Cote, Julien] CHUQ, Quebec City, PQ, Canada.
   [Chadwick, P.] Salford Primary Care Trust, Salford, Lancs, England.
   [Hurd, Theresa] Nursing Practice Solut, Toronto, ON, Canada.
   [Dunn, Raymond] UMass Mem Healthcare, Dept Surg, Div Plast Surg, Worcester, MA USA.
C3 Smith & Nephew; Smith & Nephew; Laval University; Laval University
   Hospital; University of Massachusetts System; University of
   Massachusetts Worcester
RP Smith, J (通讯作者)，Smith & Nephew Wound Management, 101 Hessle Rd, Kingston Upon Hull HU32BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
FU Smith Nephew
FX Funding for this clinical trial was provided by Smith & Nephew.
   Employees of the study sponsors contributed to study design(T. Mole, J.
   Cockwill), carried out data assessment (T. Mole, J. Smith), statistical
   analysis (T. Mole) and interpretation (J. Smith) and provided medical
   writing services (J. Smith). Authors J. Cote, P. Chadwick, and T. Hurd
   all contributed to data collection and patient evaluation. All authors
   contributed to and approved the manuscript.
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NR 16
TC 7
Z9 9
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PY 2011
VL 9
IS 3
BP 258
EP 262
DI 10.1016/j.ijsu.2010.12.005
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 832BL
UT WOS:000295775300016
PM 21187174
DA 2026-07-24
ER

PT J
AU Boone, D
   Braitman, E
   Gentics, C
   Afthinos, J
   Latif, J
   Sordillo, E
   Todd, G
   Lantis, JC
AF Boone, Deva
   Braitman, Elissa
   Gentics, Cynthia
   Afthinos, John
   Latif, Jawad
   Sordillo, Emilia
   Todd, George
   Lantis, John C., II
TI Bacterial Burden and Wound Outcomes as Influenced by Negative Pressure
   Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL
AB Negative pressure wound therapy (NPWT) has consistently shown significant clinical benefits in wound healing, but the mechanisms are not fully elucidated. While a reduction in bacterial burden is one possible contributor, studies have shown mixed results in this regard. The present study used a porcine infected wound model to test the effect of NPWT on bacterial burden. Methods. Infected wounds (Pseudomonas aeruginosa, coagulase negative Staphylococcus, and Bacteroides fragilis) in a porcine model were treated with V.A.C.(R) therapy with the standard GranuFoam (TM) dressing, V.A.C. therapy with the GranuFoam Silver (R) dressing, or moist gauze for a period of 7 days with three dressing changes. Quantitative and semiquantitative bacterial cultures, histological samples, and digital photographs were taken at dressing changes. Results. The wounds continued to show gross and microscopic improvement when treated with standard NPWT and NPWT with silver compared to moist wound care controls. However, the bacterial burden in all wounds continued to increase and broadened to include local skin flora, which had been absent immediately after wounding. These increases in bacteria were not affected by the use of silver dressings. Conclusion. Negative pressure wound therapy with either standard NPWT foam or silver NPWT foam produced significant improvements in local wound appearance. This occurred despite a persistently high level of bacterial infection; thus, the improvement in healing of these infected wounds cannot be explained by a change in the bacterial burden.
C1 [Boone, Deva; Braitman, Elissa; Gentics, Cynthia; Afthinos, John; Latif, Jawad; Sordillo, Emilia; Todd, George; Lantis, John C., II] Columbia Univ, St Lukes Roosevelt Hosp, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Columbia Univ, St Lukes Roosevelt Hosp, 1111 Amsterdam Ave,MU 208, New York, NY 10025 USA.
EM JLantis@chpnet.org
RI Sordillo, Emilia Mia/AAF-3012-2021
OI Sordillo, Emilia Mia/0000-0001-7787-3051
FU Nitric Bio, Inc (Bristol, Pa)
FX The facility performing this work was in part supported by an
   unrestricted grant from Nitric Bio, Inc (Bristol, Pa). The V.A.C.
   devices used for the study were provided by KCI (San Antonio, Tex).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 11
TC 18
Z9 23
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2010
VL 22
IS 2
BP 32
EP 37
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 559NT
UT WOS:000274833000004
PM 25901723
DA 2026-07-24
ER

PT J
AU Prichayudh, S
   Thammacharoen, E
   Sriussadaporn, S
   Pak-art, R
   Sriussadaporn, S
   Kritayakirana, K
   Samorn, P
   Narueponjirakul, N
AF Prichayudh, Supparerk
   Thammacharoen, Eakkaluck
   Sriussadaporn, Suvit
   Pak-art, Rattaplee
   Sriussadaporn, Sukanya
   Kritayakirana, Kritaya
   Samorn, Pasurachate
   Narueponjirakul, Natawat
TI Wall vacuum-assisted closure technique for a complex enteroatmospheric
   fistula: report of a case
SO ASIAN BIOMEDICINE
LA English
DT Article
DE Enteroatmospheric fistula; negative pressure wound therapy;
   vacuum-assisted closure; wall VAC
ID OPEN ABDOMEN; MANAGEMENT; THERAPY
AB Background: An enteroatmospheric fistula (EAF) is a devastating complication of abdominal surgery. EAF wound care is uniformly problematic and burdensome because the fistula effluent is difficult to contain, causing several abdominal skin problems.
   Objectives: To report the case of a complex EAF in a patient in whom conventional wound care techniques failed to contain the fistula.
   Methods: We reviewed the patient's medical records and the novel wound care technique used to contain the fistula.
   Results: We report the use of a modified vacuum-assisted closure (VAC) technique, the "Wall VAC", for the wound care of a patient with a complex EAF having large and multiple fistula openings following multiple abdominal operations. The Wall VAC technique consists of (1) leveling the skin surrounding the EAF wound, (2) creating the Wall VAC using a rectangular-shaped VAC sponge with 2 suction systems, and (3) sealing the system with a plastic bag and incise drape. By using this technique, the fistula effluent was effectively contained and the abdominal skin was well protected. The system changed every 3 to 4 days.
   Conclusions: Our modified VAC technique, the "Wall VAC", is simple and effective in containing a large volume (3,000 to 4,000 mL) of fistula effluent and protecting the abdominal skin in a patient with a complex EAF. We recommend this particular technique as an alternative method for managing a complex EAF.
C1 [Prichayudh, Supparerk; Thammacharoen, Eakkaluck; Sriussadaporn, Suvit; Pak-art, Rattaplee; Sriussadaporn, Sukanya; Kritayakirana, Kritaya; Samorn, Pasurachate; Narueponjirakul, Natawat] Chulalongkorn Univ, Dept Surg, Fac Med, Bangkok 10330, Thailand.
C3 Chulalongkorn University
RP Prichayudh, S (通讯作者)，Chulalongkorn Univ, Dept Surg, Fac Med, Bangkok 10330, Thailand.
EM supparerk.p@chula.ac.th
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NR 9
TC 1
Z9 1
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD JUN
PY 2017
VL 11
IS 3
BP 261
EP 265
DI 10.5372/1905-7415.1103.557
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FW4MR
UT WOS:000425288200008
DA 2026-07-24
ER

PT J
AU Zwanenburg, PR
   Tol, BT
   de Vries, FEE
   Boermeester, MA
AF Zwanenburg, Pieter R.
   Tol, Berend T.
   de Vries, Fleur E. E.
   Boermeester, Marja A.
TI Incisional Negative Pressure Wound Therapy for Surgical Site Infection
   Prophylaxis in the Post-Antibiotic Era
SO SURGICAL INFECTIONS
LA English
DT Review
DE incision management; microbial resistance; negative pressure wound
   therapy; prophylaxis; prevention
ID VACUUM-ASSISTED CLOSURE; IMPROVEMENT PROJECT MEASURES; HIGH-RISK
   PATIENTS; MAJOR MUSCLE FLAP; COLORECTAL SURGERY; VASCULAR-SURGERY;
   MANAGEMENT-SYSTEM; INSPIRED OXYGEN; GENERAL-SURGERY; OBESE-PATIENTS
AB Background: With the prospect of antibiotic failure in the post-antibiotic era, strategies that prevent surgical site infection (SSI) are increasingly important. Current literature suggests that incisional Negative Pressure Wound Therapy (iNWPT) is a promising intervention. Methods: Based on published literature regarding iNPWT, its mechanisms of action, and clinical results, a narrative summary was built, including both the experimental as well as the clinical literature. Results: The experimental literature indicates that iNPWT provides a barrier against external contamination before re-epithelialization, increases blood flow and lymphatic clearance, and reduces edema. Meta-analyses of randomized studies indicate that iNWPT is effective in reducing SSI. We did not identify studies that assessed bacterial clearance during iNPWT in contaminated surgical sites, nor did we identify clinical studies that specified they omitted concomitant antibiotic prophylaxis. Conclusions: Moderate quality evidence indicates that iNWPT reduces SSI, although data without the concomitant use of antibiotic prophylaxis are lacking. The iNPWT is likely effective as a result of its barrier function and optimization of the surgical site micro-environment. For now, iNPWT is recommended for incorporation in SSI prevention bundles. The iNPWT as a substitute for antibiotic prophylaxis is not recommended currently. Further reduction of SSI by iNPWT will lessen the need for therapeutic use of antibiotic agents.
C1 [Zwanenburg, Pieter R.; Tol, Berend T.; de Vries, Fleur E. E.; Boermeester, Marja A.] Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam
RP Boermeester, MA (通讯作者)，Univ Amsterdam, Amsterdam Gastroenterol & Metab, Amsterdam Infect & Immun, Dept Surg,Amsterdam UMC, Meibergdreef 9, NL-1100 DD Amsterdam, Netherlands.
EM m.a.boermeester@amc.nl
OI Boermeester, Marja/0000-0003-3890-8105
FU Acelity/KCI, San Antonio, TX; JJ/Ethicon; Acelity/KCI;
   Allergan/LifeCell; Ipsen; Baxter; Mylan; Bard
FX This work was supported by an institutional grant from Acelity/KCI, San
   Antonio, TX.M.A. Boermeester reports institutional grants from
   J&J/Ethicon, Acelity/KCI, Allergan/LifeCell, Ipsen, Baxter, Mylan, Bard,
   and is an advisory board member of J&J/Ethicon, Acelity/KCI, Bard, and
   Allergan/LifeCell, for research and expertise. P.R. Zwanenburg is a
   speaker for GD Medical Pharma BV and Hospithera NV (Negative Pressure
   Wound Therapy distribution companies). For B.T. Tol and F.E.E. de Vries,
   no competing financial interests exist.
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   Yu YC, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000005925
   Zaidi A, 2017, COLORECTAL DIS, V19, P283, DOI 10.1111/codi.13458
   Zhou ZY, 2016, J FOOT ANKLE SURG, V55, P129, DOI 10.1053/j.jfas.2015.08.013
NR 141
TC 9
Z9 9
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD NOV
PY 2018
VL 19
IS 8
SI SI
BP 821
EP 830
DI 10.1089/sur.2018.212
EA SEP 2018
PG 10
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA HD8RY
UT WOS:000446012300001
PM 30272529
DA 2026-07-24
ER

PT J
AU Jha, RK
   Xia, CY
   Li, ZH
   Wang, WY
   Deng, K
AF Jha, Ramesh Kumar
   Xia, Chengyan
   Li, Zonghuan
   Wang, Weiyang
   Deng, Kai
TI Combined negative pressure wound therapy with open bone graft for
   infected wounds with bone defects: An experimental study
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Bone and soft-tissue defect; bone graft; infected wound; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; FRACTURES; MECHANISM
AB Background: Bone and soft-tissue defects in infected wound have been an intractable problem to many surgical consultations. Infected wounds with bone defects are physical and financial burden to society. Nowadays, infected wounds with compound defect of bone and soft tissues are common in orthopedics department. Currently, no simple and efficient treatment has been found to solve this problem. This study investigates the effects of combining negative pressure wound therapy (NPWT) with open bone graft on this focus.
   Materials and Methods: Twenty four rabbits with bone and soft tissue defects accompanied infected wounds were randomized into experimental (combined NPWT with open bone graft) and contrast group (only open bone graft). Treatment efficacy was assessed by the wound condition; wound healing time, bacterial bioburden, and bony callus were evaluated by X-ray. Furthermore, samples of granulation tissue from wounds on the 3rd, 7th, and 14th days of healing were evaluated for blood vessels and expression of vascular endothelial growth factor.
   Results: Wounds in the experimental group tended to have shorter healing time, healthier wound conditions, lower bacterial bioburden, better bony callus, and more blood supply than those in the controlled group.
   Conclusions: In conclusion, NPWT combined open bone graft can act as a feasible and valuable method to treat combined infected bone and soft-tissue defects.
C1 [Jha, Ramesh Kumar; Xia, Chengyan; Li, Zonghuan; Wang, Weiyang; Deng, Kai] Wuhan Univ, Dept Orthopaed, Zhongnan Hosp, Wuhan, Hubei Province, Peoples R China.
C3 Wuhan University
RP Deng, K (通讯作者)，169 East Lake Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM dk_1005@hotmail.com
FU Province Science Funds of Hubei, China [2012FFB04311]
FX This work was financed by Province Science Funds of Hubei, China
   (Project code: 2012FFB04311).
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NR 19
TC 0
Z9 1
U1 0
U2 10
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD MAY-JUN
PY 2017
VL 51
IS 3
BP 318
EP 323
DI 10.4103/ortho.IJOrtho_220_16
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EU4JM
UT WOS:000400995600011
PM 28566785
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Soares, MO
   Bojke, L
   Dumville, J
   Iglesias, C
   Cullum, N
   Claxton, K
AF Soares, Marta O.
   Bojke, Laura
   Dumville, Jo
   Iglesias, Cynthia
   Cullum, Nicky
   Claxton, Karl
TI Methods to elicit experts' beliefs over uncertain quantities:
   application to a cost effectiveness transition model of negative
   pressure wound therapy for severe pressure ulceration
SO STATISTICS IN MEDICINE
LA English
DT Article
DE cost-effectiveness; expert; elicitation; decision analytic models;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; BAYESIAN-ANALYSIS; CARE; PATIENT; TRIAL;
   DISTRIBUTIONS; PROBABILITIES; OPINION; DESIGN
AB We can use decision models to estimate cost effectiveness, quantify uncertainty regarding the adoption decision and provide estimates of the value of further research. In many cases, the existence of only limited data with which to populate a decision model can mean that a cost-effectiveness analysis either does not proceed or may misrepresent the degree of uncertainty associated with model inputs. An example is the case of negative pressure wound therapy (NPWT) used to treat severe pressure ulceration, for which the evidence base is limited and sparse. There is, however, substantial practical experience of using this treatment and its comparators. We can capture this knowledge quantitatively to inform a cost-effectiveness model by eliciting beliefs from experts.
   This paper describes the design and conduct of an elicitation exercise to generate estimates of multiple uncertain model inputs and validate analytical assumptions for a decision model on the use of NPWT. In designing the exercise, the primary focus was the use of elicitation to inform decision models (multistate models), where representations of uncertain beliefs need to be probabilistically coherent. This paper demonstrates that it is feasible to collect formally elicited evidence to inform decision models. Copyright (C) 2011 John Wiley & Sons, Ltd.
C1 [Soares, Marta O.; Bojke, Laura; Claxton, Karl] Univ York, Ctr Hlth Econ, York YO10 5DD, N Yorkshire, England.
   [Dumville, Jo; Iglesias, Cynthia; Cullum, Nicky] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England.
C3 University of York - UK; University of York - UK
RP Soares, MO (通讯作者)，Univ York, Ctr Hlth Econ, Alcuin A Block, York YO10 5DD, N Yorkshire, England.
EM marta.soares@york.ac.uk
RI Soares, Marta Ferreira Oliveira/HJH-3434-2023; Dumville, Jo/O-7867-2014;
   Cullum, Nicky/F-2438-2011
OI Soares, Marta Ferreira Oliveira/0000-0003-1579-8513; Dumville,
   Jo/0000-0002-6546-3685; Cullum, Nicky/0000-0003-2631-123X
FU Medical Research Council [G0501814, MC_U145079308, G0501892] Funding
   Source: Medline; MRC [MC_U145079308, G0501814, G0501892] Funding Source:
   UKRI; Medical Research Council [G0501814, G0501892, MC_U145079308]
   Funding Source: researchfish
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NR 60
TC 43
Z9 48
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-6715
EI 1097-0258
J9 STAT MED
JI Stat. Med.
PD AUG 30
PY 2011
VL 30
IS 19
BP 2363
EP 2380
DI 10.1002/sim.4288
PG 18
WC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Medicine, Research &
   Experimental; Statistics & Probability
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Mathematical & Computational Biology; Public, Environmental &
   Occupational Health; Medical Informatics; Research & Experimental
   Medicine; Mathematics
GA 805ON
UT WOS:000293738600003
PM 21748773
DA 2026-07-24
ER

PT J
AU Li, ZH
   Wang, QH
   Mi, WX
   Han, M
   Gao, F
   Niu, GY
   Ma, YD
AF Li, Zhihong
   Wang, Qihong
   Mi, Wenxin
   Han, Mei
   Gao, Fei
   Niu, Guangyan
   Ma, Yindong
TI 被撤回的出版物: Effects of negative-pressure wound therapy combined with
   microplasma on treating wounds of ulcer and the expression of heat shock
   protein 90 (Retracted article. See vol. 30, 2025)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article; Retracted Publication
DE negative-pressure wound therapy; microplasma; ulceration; blood
   perfusion; angiogenesis; heat shock protein 90
ID VACUUM-ASSISTED CLOSURE; BED PREPARATION
AB The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n= 20 cases), the NPWT group (n= 22 cases) and the combination group (NPWT combined with microplasma) (n= 22 cases), and compared the effects. It was found that in the 7 and 14 day combination group, maturity of granulation tissues and growth degree of epithelium were significantly higher than those in other two groups, and the areas of ulcer reduced significantly, the healing rate increased significantly (P< 0.05). In the 7 and 14 day combination group, blood perfusion of wounds and density of new vessels were significantly higher than the other two groups (P< 0.05). In the 7 and 14 day combination group, the expression of HSP90 was significantly higher than the other two groups (P< 0.05). In conclusion, NPWT combined with microplasma can improve the healing of woulds of ulcers, and it is related to the upregulated expression of HSP90.
C1 [Li, Zhihong; Wang, Qihong; Mi, Wenxin; Han, Mei; Gao, Fei; Niu, Guangyan; Ma, Yindong] Shandong Univ, Jinan Cent Hosp, Dept Bums Surg, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University
RP Ma, YD (通讯作者)，Shandong Univ, Jinan Cent Hosp, Dept Bums Surg, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China.
EM yindong_ma1@163.com
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NR 20
TC 10
Z9 12
U1 1
U2 12
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAY
PY 2017
VL 13
IS 5
BP 2211
EP 2216
DI 10.3892/etm.2017.4266
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EU5NG
UT WOS:000401078200081
PM 28565829
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, ZF
   Zhao, DW
   Wang, BJ
AF Liu, Zhaofa
   Zhao, Dewei
   Wang, Benjie
TI Improved vacuum sealing drainage in the treatment of gas gangrene: a
   case report
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Gas gangrene; vacuum sealing drainage; treatment
AB In this case, improved vacuum sealing drainage was used for gas gangrene treatment, which is different from traditional therapies of gas gangrene and this is the first report of using improved vacuum sealing drainage to treat gas gangrene. The patient was a 12-year-old Asian Male who was presented to the Emergency Department with a one-day history of left femoral progressing swelling, paining and fevering. Four days ago, rusty iron bars were plugged into the muscle of the left femoral when he played. Then he was taken to the local clinic and injected with tetanus antitoxin. A diagnosis of gas gangrene was made and modified vacuum sealing drainage device was used after thorough debridement. After two weeks' treatment, left femoral was kept and gas gangrene was cured successfully.
C1 [Liu, Zhaofa; Zhao, Dewei; Wang, Benjie] Dalian Univ, Dept Orthopaed, Zhongshan Hosp, 6 Jiefang St, Dalian 116001, Liaoning, Peoples R China.
C3 Dalian University
RP Zhao, DW (通讯作者)，Dalian Univ, Dept Orthopaed, Zhongshan Hosp, 6 Jiefang St, Dalian 116001, Liaoning, Peoples R China.
EM zhaodewdl@sina.com
RI Zhao, Dewei/G-8369-2016
CR Abaid LN, 2013, INFECTION, V41, P885, DOI 10.1007/s15010-013-0426-y
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NR 11
TC 2
Z9 3
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 10
BP 19626
EP 19628
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DA3BB
UT WOS:000367669800332
PM 26770624
DA 2026-07-24
ER

PT J
AU Gigliotti, MJ
   Patel, N
   McLaughlin, C
   Rothermel, A
   Henry, C
   Rizk, E
AF Gigliotti, Michael J.
   Patel, Neel
   McLaughlin, Caroline
   Rothermel, Alexis
   Henry, Cathy
   Rizk, Elias
TI Osteoradionecrosis and microvascular free flap failure managed with
   negative pressure wound therapy: A case report
SO BRITISH JOURNAL OF NEUROSURGERY
LA English
DT Article
DE Osteoradionecrosis; negative pressure wound therapy; microvascular free
   flap; cranial
ID VACUUM-ASSISTED CLOSURE; TEMPORAL BONE; MANDIBULAR OSTEORADIONECROSIS;
   RECONSTRUCTION; RADIATION; OUTCOMES; SCALP; SKULL; HEAD
AB A 56-year-old female with a history of meningioma status post subtotal resection (Simpson grade IV) and extensive radiation therapy presented with osteoradionecrosis (O.R.N.) managed previously with a microvascular free flap (MVFF). The evaluation revealed worsening O.R.N. and a scalp defect of 15 x 10 cm. The patient underwent MVFF reconstruction utilizing a free latissimus muscle flap covered by meshed split-thickness skin graft (STSG). Her surgery was complicated by delayed free flap failure and Serratia marcescens growth, which occurred sometime after discharge from the hospital. This was managed with removal of the free muscle flap and skin graft, serial debridement's, antibiotics, and replacements of a synthetic dural matrix and negative pressure wound therapy (NPWT). Once a clean wound bed was again obtained, the patient underwent fasciocutaneous anterolateral thigh (A.L.T.) MVFF reconstruction, which was complicated by left hypoglossal nerve injury, dehiscence of the flap inset, and dehiscence of the neck access incision requiring revision surgery. On the last follow-up 2 weeks after her surgery, the patient had 100% flap viability and a 2 x 1.5 cm on the left parietal aspect of the flap healing be secondary intent. We demonstrate that NPWT is successful in managing open calvarial wounds due to O.R.N.
C1 [Gigliotti, Michael J.; Patel, Neel; Rizk, Elias] Penn State Hlth Milton S Hershey Med Ctr, Dept Neurosurg, 500 Univ Dr, Hershey, PA 17033 USA.
   [McLaughlin, Caroline; Rothermel, Alexis; Henry, Cathy] Penn State Hlth Milton S Hershey Med Ctr, Dept Plast Surg, 500 Univ Dr, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Gigliotti, MJ (通讯作者)，Penn State Hlth Milton S Hershey Med Ctr, Dept Neurosurg, 500 Univ Dr, Hershey, PA 17033 USA.
EM mgigliotti19505@gmail.com
RI ; Rizk, Elias/NEU-1860-2025
OI Gigliotti, Michael/0000-0001-8183-5832; 
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
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NR 22
TC 7
Z9 9
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0268-8697
EI 1360-046X
J9 BRIT J NEUROSURG
JI Br. J. Neurosurg.
PD NOV 2
PY 2023
VL 37
IS 6
BP 1938
EP 1943
DI 10.1080/02688697.2021.1940845
EA JUN 2021
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA HC0R6
UT WOS:000664179800001
PM 34148435
DA 2026-07-24
ER

PT J
AU Seo, SG
   Yeo, JH
   Kim, JIH
   Kim, JB
   Cho, TJ
   Lee, DY
AF Seo, Sang Gyo
   Yeo, Ji Hyun
   Kim, J. I. Hye
   Kim, Ji-Beom
   Cho, Tae-Joon
   Lee, Dong Yeon
TI Negative-pressure wound therapy induces endothelial progenitor cell
   mobilization in diabetic patients with foot infection or skin defects
SO EXPERIMENTAL AND MOLECULAR MEDICINE
LA English
DT Article
DE diabetic foot; endothelial progenitor cell; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; VASCULOGENESIS; NUMBER
AB Non healing chronic wounds are difficult to treat in patients with diabetes and can result in severe medical problems for these patients and for society. Negative-pressure wound therapy (NPWT) has been adopted to treat intractable chronic wounds and has been reported to be effective. However, the mechanisms underlying the effects of this treatment have not been elucidated. To assess the vasculogenic effect of NPWT, we evaluated the systemic mobilization of endothelial progenitor cells (EPCs) during NPWT. Twenty-two of 29 consecutive patients who presented at the clinic of Seoul National Universty Hospital between December 2009 and November 2010 who underwent NPWT for diabetic foot infections or skin ulcers were included in this study. Peripheral blood samples were taken before NPWT (pre-NPWT) and 7-14 days after the initiation of NPWT (during-NPWT). Fluorescence-activated cell sorting (FACS) analysis showed that the number of cells in EPC-enriched fractions increased after NPWT, and the numbers of EPC colony forming units (CFUs) significantly increased during NPWT. We believe that NPWT is useful for treating patients with diabetic foot infections and skin ulcers, especially when these conditions are accompanied by peripheral arterial insufficiency. The systemic mobilization of EPCs during NPWT may be a mechanism for healing intractable wounds in diabetic patients with foot infections or skin defects via the formation of increased granulation tissue with numerous small blood vessels.
C1 [Seo, Sang Gyo; Yeo, Ji Hyun; Kim, J. I. Hye; Kim, Ji-Beom; Cho, Tae-Joon; Lee, Dong Yeon] Seoul Natl Univ, Coll Med, Dept Orthoped Surg, Seoul, South Korea.
C3 Seoul National University (SNU)
RP Lee, DY (通讯作者)，Seoul Natl Univ Hosp, Dept Orthoped Surg, 101 Daehak Ro, Seoul 110744, South Korea.
EM leedy@snu.ac.kr
RI ; Cho, Tae-Joon/I-9355-2012
OI Seo, Sang Gyo/0000-0003-0145-4066; Cho, Tae-Joon/0000-0001-8514-377X
FU Seoul National University Hospital Research Fund [SNUH-03-2012-0430];
   National Research Foundation of Korea (NRF); Ministry of Education,
   Science and Technology [2010-0021475]
FX This work was supported by the Seoul National University Hospital
   Research Fund (SNUH-03-2012-0430) and by the Basic Science Research
   Program through the National Research Foundation of Korea (NRF), which
   was funded by the Ministry of Education, Science and Technology
   (2010-0021475).
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NR 27
TC 35
Z9 49
U1 0
U2 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1226-3613
EI 2092-6413
J9 EXP MOL MED
JI Exp. Mol. Med.
PD NOV
PY 2013
VL 45
AR e62
DI 10.1038/emm.2013.129
PG 5
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA 267UO
UT WOS:000328123900012
PM 24232261
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Waheed, MT
   Malik, I
   Ituarte, PHG
   Han, ER
   Lwin, T
   Paz, IB
   Woo, Y
   Melstrom, L
   Raoof, M
AF Waheed, Muhammad Talha
   Malik, Ibrahim
   Ituarte, Philip H. G.
   Han, Ernest
   Lwin, Thinzar
   Paz, Isaac B.
   Woo, Yanghee
   Melstrom, Laleh
   Raoof, Mustafa
TI Association of negative pressure wound therapy and surgical site
   infections in patients undergoing cytoreductive surgery: An entropy
   balanced analysis
SO JOURNAL OF SURGICAL ONCOLOGY
LA English
DT Article
DE cytoreductive surgery; negative-pressure wound therapy; NPWT; surgical
   site infection; vacuum assisted closure
ID AMERICAN-COLLEGE; PREDICTION MODEL; RISK-FACTORS; IMPACT; GUIDELINES;
   COHORT; DRAIN; COST
AB Background and Objectives: Surgical site infections (SSIs) after cytoreductive surgery (CRS) +/- hyperthermic intraperitoneal chemotherapy (HIPEC) are a major cause of potentially avoidable morbidity. We explored the association of negative pressure wound therapy (NPWT) with SSI in patients undergoing CRS/HIPEC. Methods: Retrospective analysis of consecutive patients undergoing CRS/HIPEC for non-gynecologic cancers. Exposure was the receipt of NPWT versus traditional skin closure. Primary outcome was SSI within 90 days of surgery. We performed multivariable logistic regression (before and after entropy balancing) to evaluate the association of exposure with outcomes. Results: A total of 251 patients were included, of which 43 (17%) received NPWT and 26 (10.4%) developed SSIs. Baseline demographics and clinicopathologic characteristics were similar between the two groups with some exceptions: Patients who received NPWT had a higher Peritoneal Carcinomatosis Index (median 19 vs. 11, p = 0.002) and operative time (10 vs. 8.2 h, p = 0.003) but were less likely to undergo HIPEC (84% vs. 95%, p < 0.05). After entropy balancing, on multivariable logistic regression, NPWT was not associated with 90-day SSI (odds ratio = 0.90; 95% confidence interval = 0.21-3.80; p = 0.89). Conclusion: NPWT was not associated with a reduction in SSIs. These findings prompt a reevaluation of the routine use of NPWT in CRS/HIPEC.
C1 [Waheed, Muhammad Talha; Ituarte, Philip H. G.; Han, Ernest; Paz, Isaac B.; Woo, Yanghee; Melstrom, Laleh; Raoof, Mustafa] City Hope Natl Med Ctr, Dept Surg, Duarte, CA USA.
   [Malik, Ibrahim; Lwin, Thinzar] Wayne State Univ, Sch Med, Detroit, MI USA.
C3 City of Hope; Wayne State University
RP Raoof, M (通讯作者)，City Hope Natl Med Ctr, Dept Surg, Div Surg Oncol, 1500 E Duarte Rd, Duarte, CA 91010 USA.
EM mraoof@coh.org
RI Ituarte, Philip/ABG-5332-2021
OI Waheed, Muhammad Talha/0000-0002-0679-4396; Melstrom,
   Laleh/0000-0001-6279-7981
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4790
EI 1096-9098
J9 J SURG ONCOL
JI J. Surg. Oncol.
PD OCT
PY 2024
VL 130
IS 5
BP 1139
EP 1150
DI 10.1002/jso.27828
EA AUG 2024
PG 12
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA P9Y7X
UT WOS:001293196500001
PM 39155656
OA Bronze
DA 2026-07-24
ER

PT J
AU Willy, C
   Engelhardt, M
   Stichling, M
   Grauhan, O
AF Willy, Christian
   Engelhardt, Michael
   Stichling, Marcus
   Grauhan, Onnen
TI The impact of surgical site occurrences and the role of closed incision
   negative pressure therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed incision negative pressure wound therapy; Negative pressure wound
   therapy; Surgical incision management; Surgical site infection
ID STERNAL WOUND-INFECTION; INTERNAL THORACIC ARTERY; LONG-TERM SURVIVAL;
   VACUUM-ASSISTED CLOSURE; RISK-FACTORS; DIABETIC-PATIENTS;
   CARDIAC-SURGERY; STERNOTOMY INFECTION; OBESE-PATIENTS; PREVENTION
AB Surgical site occurrences are observed in up to 60% of inpatient surgical procedures in industrialised countries. The most relevant postoperative complication is surgical site infection (SSI) because of its impact on patient outcomes and enormous treatment costs. Literature reviews (SSI', deep sternal wound infections' (DSWI), closed incision negative pressure wound therapy' (ciNPT) were performed by electronically searching MEDLINE (PubMed) and subsequently using a snowball' method of continued searches of the references in the identified publications. Search criteria included publications in all languages, various study types and publication in a peer-reviewed journal. The SSI literature search identified 1325, the DSWI search 590 and the ciNPT search 103 publications that fulfilled the search criteria. Patient-related SSI risk factors (diabetes mellitus, obesity, smoking, hypertension, female gender) and operation-related SSI risk factors (re-exploration, emergency operations, prolonged ventilation, prolonged operation duration) exist. We found that patient- and operation-related SSI risk factors were often different for each speciality and/or operative procedure. Based on the evidence, we found that high-risk incisions (sternotomy and incisions in extremities after high-energy open trauma) are principally recommended for ciNPT use. In lower'-risk incisions, the addition of patient-related or operation-related risk factors justifies the application of ciNPT.
C1 [Willy, Christian] Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Res & Treatment Ctr Complex Combat Injuries, Berlin, Germany.
   [Engelhardt, Michael] Bundeswehr Hosp Ulm, Dept Vasc & Endovasc Surg, Ctr Vasc Med, Ulm, Germany.
   [Stichling, Marcus] Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Res & Treatment Ctr Complex Combat Injuries, Sect Vasc & Thorac Surg, Berlin, Germany.
   [Grauhan, Onnen] German Heart Ctr Berlin, Cardiac Surg, Berlin, Germany.
C3 Ulm University; Military Hospital Ulm; German Heart Center Berlin
RP Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Surg, Colonel, Scharnhorststr 13, D-10115 Berlin, Germany.; Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Dept Traumatol Orthoped Surg Sept & Reconstruct S, Dept, Scharnhorststr 13, D-10115 Berlin, Germany.; Willy, C (通讯作者)，Bundeswehr Hosp Berlin, Res & Treatment Ctr Complex Combat Injuries, Wound Ctr, Bundeswehr Hosp Berlin ICW, Scharnhorststr 13, D-10115 Berlin, Germany.
EM christianwilly@bundeswehr.org
FU ACELITY
FX Dr. Willy served as a consultant to KCI, an ACELITY Company, and
   presented as a faculty member at an ACELITY symposium parallel to the
   2016 World Union of Wound Healing Societies (WUWHS) conference. Dr.
   Grauhan is a consultant to KCI, an ACELITY Company. This article is part
   of a ACELITY-funded supplement based on the 2016 WUWHS ACELITY symposium
   presentations. ACELITY provided editorial assistance.
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NR 67
TC 14
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP
PY 2016
VL 13
SU 3
SI SI
BP 35
EP 46
DI 10.1111/iwj.12659
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DW4HL
UT WOS:000383603700006
PM 27547962
OA Green Accepted
DA 2026-07-24
ER

PT J
AU Langer, V
   Bhandari, PS
   Rajagopalan, S
   Mukherjee, MK
AF Langer, Vijay
   Bhandari, Prem S.
   Rajagopalan, Satyamoorthy
   Mukherjee, Mrinal K.
TI Negative pressure wound therapy as an adjunct in healing of chronic
   wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wounds; Negative pressure wound therapy; Vacuum sealing
   technique; Wound bed preparation; Wounds and injuries
ID VACUUM-ASSISTED CLOSURE; GLYCATION END-PRODUCTS; EXPERIENCE; DEVICE;
   TRIAL
AB Negative pressure wound therapy (NPWT) has emerged as a cutting-edge technology and provides an alternative solution to the problem of wounds. This study was undertaken to assess the efficacy of this technique in the treatment of chronic wounds. A prospective clinical study was used to evaluate our experience in use of NPWT in the healing of pressure ulcers and chronic wounds over 2 years. The primary end point of the study group was the time taken for appearance of healthy granulation tissue and full reepithelialisation without drainage. All patients with sepsis were excluded from the study. The statistical analysis of the data was carried out. Of the 60 patients studied, 41 had associated comorbidities including diabetes mellitus. The commonest site of occurrence was the lower limb. Coverage in the form of a flap was required at presentation in 6333% of patients. However, after initiation of NPWT, none of them required the procedure and they healed spontaneously either by secondary intention or by skin grafting. The time taken for appearance of healthy granulation tissue was 1436 +/- 424 days. Complete healing of wounds occurred by 331 +/- 1022 days. There was a statistically significant difference in the volume of the wounds before and after the intervention (P = 0000). Complications resulting from NPWT were minimal. This technique is an excellent adjunct to surgical debridement.
C1 [Langer, Vijay; Bhandari, Prem S.; Mukherjee, Mrinal K.] Army Hosp Res & Referral, Dept Plast & Reconstruct Surg, New Delhi 110010, India.
   [Rajagopalan, Satyamoorthy] Armed Forces Med Coll, Dept Surg, Pune, Maharashtra, India.
C3 Armed Forces Medical College
RP Langer, V (通讯作者)，Army Hosp Res & Referral, Dept Plast & Reconstruct Surg, New Delhi 110010, India.
EM vlangz@gmail.com
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NR 30
TC 28
Z9 34
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2015
VL 12
IS 4
BP 436
EP 442
DI 10.1111/iwj.12132
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CM2OI
UT WOS:000357520400011
PM 23855645
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Navsaria, P
   Nicol, A
   Hudson, D
   Cockwill, J
   Smith, J
AF Navsaria, Pradeep
   Nicol, Andrew
   Hudson, Donald
   Cockwill, John
   Smith, Jennifer
TI Negative pressure wound therapy management of the "open abdomen"
   following trauma: a prospective study and systematic review
SO WORLD JOURNAL OF EMERGENCY SURGERY
LA English
DT Review
DE Negative Pressure Wound Therapy (NPWT); Grade 1 and 2 open abdomen;
   Abdominal trauma; Fascial closure
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; FASCIAL
   CLOSURE; INTRAABDOMINAL HYPERTENSION; RETROSPECTIVE EVALUATION
AB Introduction: The use of Negative Pressure Wound Therapy (NPWT) for temporary abdominal closure of open abdomen (OA) wounds is widely accepted. Published outcomes vary according to the specific nature and the aetiology that resulted in an OA. The aim of this study was to evaluate the effectiveness of a new NPWT system specifically used OA resulting from abdominal trauma.
   Methods: A prospective study on trauma patients requiring temporary abdominal closure (TAC) with grade 1 or 2 OA was carried out. All patients were treated with NPWT (RENASYS AB Smith & Nephew) to achieve TAC. The primary outcome measure was time taken to achieve fascial closure and secondary outcomes were complications and mortality.
   Results: A total of 20 patients were included. Thirteen patients (65%) achieved fascial closure following a median treatment period of 3 days. Four patients (20%) died of causes unrelated to NPWT. Complications included fistula formation in one patient (5%) with spontaneous resolution during NPWT), bowel necrosis in a single patient (5%) and three cases of infection (15%). No fistulae were present at the end of NPWT.
   Conclusion: This new NPWT kit is safe and effective and results in a high rate of fascial closure and low complication rates in the severely injured trauma patient.
C1 [Navsaria, Pradeep; Nicol, Andrew; Hudson, Donald] Univ Cape Town, Dept Surg, Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
   [Cockwill, John] Smith & Nephew, St Petersburg, FL USA.
   [Smith, Jennifer] Smith & Nephew, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 University of Cape Town; Smith & Nephew; Smith & Nephew
RP Smith, J (通讯作者)，Smith & Nephew, 101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
RI Navsaria, Pradeep/AAS-1807-2020
OI Navsaria, Pradeep/0000-0002-5152-3317
FU Smith Nephew (SN)
FX This study was funded by Smith & Nephew (S&N). Authors JS and JC are
   employees of S&N. DH was part of an International Expert Panel on
   Negative Pressure Wound Therapy funded by an unrestricted educational
   grant provided by Smith & Nephew.
CR [Anonymous], OPEN ABDOMEN TREATME
   [Anonymous], EUR J TRAUMA
   [Anonymous], COLORECTAL DIS OFFIC
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NR 26
TC 42
Z9 50
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-7922
J9 WORLD J EMERG SURG
JI World J. Emerg. Surg.
PD JAN 10
PY 2013
VL 8
AR 4
DI 10.1186/1749-7922-8-4
PG 8
WC Emergency Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine; Surgery
GA 119DM
UT WOS:000317077600001
PM 23305306
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kuper, TM
   Murphy, PB
   Kaur, B
   Ott, MC
AF Kuper, Tanya M.
   Murphy, Patrick B.
   Kaur, Bandeep
   Ott, Michael C.
TI Prophylactic Negative Pressure Wound Therapy for Closed Laparotomy
   Incisions A Meta-analysis of Randomized Controlled Trials
SO ANNALS OF SURGERY
LA English
DT Article
DE general surgery; negative pressure wound therapy; surgical site
   infections
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   PREVENTION; SURGERY; AGREEMENT
AB Objective: The aim of this study was to determine whether negative pressure wound therapy (NPWT) applied to primarily closed incisions decreases surgical site infections (SSIs) following open abdominal surgery. Background: SSIs are a common cause of morbidity following open abdominal surgery. Prophylactic NPWT has shown promise for SSI reduction. However, the results of randomized controlled trials (RCTs) conducted among patients undergoing laparotomy have been inconsistent. Methods: We performed a meta-analysis of English language RCTs comparing the use of prophylactic NPWT to standard dressings on primarily closed laparotomy incisions following open abdominal surgery. Medline, EMBASE, Cochrane Library, and CINAHL databases were searched from inception to December 31(st), 2018, for relevant studies. A random-effects model was used for statistical analysis. Results: Five RCTs totaling 792 patients were included in our meta-analysis after application of our exclusion and inclusion criteria. There was no significant difference in the risk of SSIs identified among those patients who had NPWT compared to standard dressings; relative risk (RR) 0.56 (95% confidence interval 0.30-1.03, P = 0.064). There was significant statistical heterogeneity across studies (I-2 = 67.4%; P = 0.015). Conclusion: The adoption of NPWT for routine SSI prophylaxis following laparotomy is currently not supported and should be used primarily in the context of a clinical trial.
C1 [Kuper, Tanya M.; Murphy, Patrick B.; Ott, Michael C.] Western Univ, Schulich Sch Med & Dent, Div Gen Surg, Dept Surg, London, ON, Canada.
   [Kaur, Bandeep] Western Univ, Schulich Sch Med & Dent, London, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario)
RP Kuper, TM (通讯作者)，Western Univ, Schulich Sch Med & Dent, Div Gen Surg, Dept Surg, London, ON, Canada.
EM kuper.tanya@gmail.com
RI ; Murphy, Patrick/T-5337-2019
OI Ott, Michael/0000-0002-0816-7089; 
CR Atkins BZ, 2009, SURG INNOV, V16, P140, DOI 10.1177/1553350609334821
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NR 32
TC 48
Z9 51
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2020
VL 271
IS 1
BP 67
EP 74
DI 10.1097/SLA.0000000000003435
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LC0JF
UT WOS:000525016300016
PM 31860549
DA 2026-07-24
ER

PT J
AU Lim, S
   Lee, DY
   Kim, B
   Yoon, JS
   Han, YS
   Eo, S
AF Lim, SooA
   Lee, Dong Yun
   Kim, BumSik
   Yoon, Jung Soo
   Han, Yea Sik
   Eo, SuRak
TI Devastating complication of negative pressure wound therapy after deep
   inferior epigastric perforator free flap surgery: A case report
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Article
DE Negative Pressure Wound Therapy; Complications; Breast reconstruction;
   Deep inferior epigastric artery perforator; Free flap; Burn injury; Case
   report
ID VACUUM-ASSISTED CLOSURE; BURN; MANAGEMENT; SAFETY
AB BACKGROUND
   Thermal injuries on free transferred or replanted tissues resulting from loss of sensibility are an infrequent occurrence. They require immediate and appropriate management before they progress to an irreversible condition. Although negative pressure wound therapy (NPWT) can prevent wound progression by increasing microcirculation, the inappropriate application of NPWT on complication-threatened transferred and replanted tissues can induce an adverse effect. CASE SUMMARY
   A 48-year-old woman who underwent immediate breast reconstruction with a deep inferior epigastric artery perforator free flap. While applying a heating pad directly to the flap site, she sustained a deep second to third-degree contact burn over 30% of the transferred flap on postoperative 7 d. As the necrotic changes had progressed, we applied an NPWT dressing over the burned area after en-bloc debridement of the transferred tissues on postoperative 21 d. After 4 d of NPWT application, the exposed fatty tissues of the flap changed to dry and brown-colored necrotic tissues. Upon further debridement, we noted that the wound gradually reached total necrosis with a collapsed vascular pedicle of deep inferior epigastric artery. CONCLUSION
   Although NPWT has been shown to be successful for treating various wound types, the significant risk of NPWT application in short-lasting reconstructed flap wounds after thermal injury should be reminded.
C1 [Lim, SooA; Lee, Dong Yun; Kim, BumSik; Yoon, Jung Soo; Han, Yea Sik; Eo, SuRak] DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Dongguk Ro 77, Goyang 10326, South Korea.
C3 Dongguk University
RP Eo, S (通讯作者)，DongGuk Univ, Med Ctr, Dept Plast & Reconstruct Surg, Dongguk Ro 77, Goyang 10326, South Korea.
EM sreodoc@gmail.com
RI ; Lee, Dong Yun/QPA-1583-2026; Eo, SuRak/JXM-4124-2024
OI Lee, Dong Yun/0000-0002-5323-6469; Yoon, Jung Soo/0000-0003-2462-5702
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NR 23
TC 1
Z9 2
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD JAN 6
PY 2023
VL 11
IS 1
BP 143
EP 149
DI 10.12998/wjcc.v11.i1.143
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8R7LD
UT WOS:000928071200015
PM 36687191
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wang, YJ
   Yao, XF
   Lin, YS
   Wang, JY
   Chang, CC
AF Wang, Yen-Jen
   Yao, Xiao-Feng
   Lin, Yang-Sheng
   Wang, Jen-Yu
   Chang, Chang-Cheng
TI Oncologic feasibility for negative pressure wound therapy application in
   surgical wounds: A meta-analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE malignant neoplasms; melanoma; negative-pressure wound therapy;
   recurrence; sarcoma
ID VACUUM-ASSISTED CLOSURE; ACRAL LENTIGINOUS MELANOMA; INGUINAL
   LYMPHADENECTOMY; SITE INFECTION; PENILE CANCER; OPEN ABDOMEN;
   COMPLICATIONS; HYPOXIA; VULVECTOMY; MANAGEMENT
AB Negative pressure wound therapy (NPWT) decreases postoperative complications of various surgeries. However, the use of NPWT for oncological surgical wounds remains controversial. To evaluate the association of NPWT with oncologic recurrence in surgical wounds without residual malignancy, we analysed studies that compared NPWT with conventional non-pressure dressings for cancer surgical wounds without residual tumour by August 12, 2020. We compared tumour recurrence rates and postoperative complications between the two procedures. The six studies included 118 patients who received NPWT, and 149 patients who received conventional non-pressure wound care. The overall quality of the included studies was high based on the Newcastle-Ottawa scale score of 7.5. Tumour recurrence after NPWT was not significantly different compared with conventional non-negative pressure wound care (9.3% versus 11.4%, P = 0.40). There was no significant heterogeneity between the studies (I-2 = 3%). Although NTWT was associated with a lower complication rate compared with the control group, the result was non-significant (P = 0.15). Application of NPWT in oncologic resection wounds without residual malignancy revealed no difference in local recurrence and may reduce the risk of postoperative complications compared with conventional non-negative pressure dressings. NPWT can be considered an alternative method for reconstruction in challenging cases.
C1 [Wang, Yen-Jen; Yao, Xiao-Feng; Wang, Jen-Yu] MacKay Mem Hosp, Dept Dermatol, Taipei, Taiwan.
   [Wang, Yen-Jen] Mackay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Med Coll, Dept Med, New Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Lin, Yang-Sheng] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, Dept Cosmeceut, Taichung, Taiwan.
   [Chang, Chang-Cheng] Natl Yang Ming Chiao Tung Univ, Inst Imaging & Biomed Photon, Tainan, Taiwan.
   [Chang, Chang-Cheng] China Med Univ Hosp, Aesthet Med Ctr, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
   [Chang, Chang-Cheng] China Med Univ, China Med Univ Hosp, Coll Med, Med, Taichung, Taiwan.
C3 Mackay Memorial Hospital; Mackay Junior College of Medicine, Nursing &
   Management; Mackay Medical University; Mackay Memorial Hospital; Mackay
   Memorial Hospital; Taipei Medical University; China Medical University
   Taiwan; National Yang Ming Chiao Tung University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Hospital - Taiwan
RP Chang, CC (通讯作者)，China Med Univ Hosp, Aesthet Med Ctr, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM changcc1975@gmail.com
OI Wang, Yen-Jen/0000-0002-0425-9154
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NR 53
TC 14
Z9 17
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2022
VL 19
IS 3
BP 573
EP 582
DI 10.1111/iwj.13654
EA JUN 2021
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ZH2HY
UT WOS:000667602500001
PM 34184411
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ibrahim, ZM
   Waked, IS
   Ibrahim, O
AF Ibrahim, Zizi M.
   Waked, Instar S.
   Ibrahim, Olfat
TI Negative pressure wound therapy versus microcurrent electrical
   stimulation in wound healing in burns
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE burn injury; microcurrent electrical stimulation; negative pressure
   wound therapy; wound healing
ID VACUUM-ASSISTED CLOSURE; LASER IRRADIATION; INJURY; COST; LOAD
AB Objective: To compare the efficacy of negative pressure wound therapy (NPWT) with that of microcurrent electrical stimulation (MES) on wound surface area, length of stay (LoS) and colony count of wounds in patients with burns.
   Method: Patients with thermal dermal burn injuries covering 25-40% of total body surface area were enrolled in this clinical trial. Participants were randomly allocated into three, equal-sized groups: patients receiving NPWT, patients receiving MES and a control group which received standard wound care. All groups received the same traditional physical therapy programme in addition to the same nursing and medical care. In all groups, wound surface area, colony count and LoS were measured 72 hours after thermal burn injury (pre), after 10 days and again at 21 days from the beginning of the study.
   Results: A total of 45 patients took part in the study. There were statistically significant decreases in wound surface area observed in all groups (p<0.05) while MES showed the highest mean percentage of reduction in wound surface. MES and NPWT both showed the lowest values for bacterial growth but NPWT was superior in colony count reduction. For LoS, both MES and NPWT showed the lowest mean value.
   Conclusion: From the findings of this study, MES was more effective in decreasing wound surface area in burn wounds while NPWT was more effective in reducing bacterial growth.
C1 [Ibrahim, Zizi M.; Waked, Instar S.] Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Surg, Giza, Egypt.
   [Ibrahim, Zizi M.] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Rehabil Sci Dept, Riyadh, Saudi Arabia.
   [Ibrahim, Olfat] Cairo Univ, Fac Phys Therapy, Dept Basic Sci Phys Therapy, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Princess Nourah bint
   Abdulrahman University; Egyptian Knowledge Bank (EKB); Cairo University
RP Ibrahim, ZM (通讯作者)，Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Surg, Giza, Egypt.; Ibrahim, ZM (通讯作者)，Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Rehabil Sci Dept, Riyadh, Saudi Arabia.
EM zizikahla@yahoo.com
RI Ibrahim Ali, Olfat/M-7832-2019; /AAF-1738-2021; IBRAHIM,
   ZIZI/AAA-8191-2020
OI Ibrahim Ali, Olfat/0000-0003-4279-3662; 
CR Ahmed AF, 2012, J ADV RES, V3, P109, DOI 10.1016/j.jare.2011.05.004
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NR 36
TC 26
Z9 32
U1 0
U2 32
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2019
VL 28
IS 4
BP 214
EP 219
DI 10.12968/jowc.2019.28.4.214
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HS0UA
UT WOS:000463574700005
PM 30975055
DA 2026-07-24
ER

PT J
AU Biter, LU
   Beck, GMN
   Mannaerts, GHH
   Stok, MM
   van der Ham, AC
   Grotenhuis, BA
AF Biter, L. Ulas
   Beck, Guyon M. N.
   Mannaerts, Guido H. H.
   Stok, Myrte M.
   van der Ham, Arie C.
   Grotenhuis, Brechtje A.
TI The Use of Negative-Pressure Wound Therapy in Pilonidal Sinus Disease: A
   Randomized Controlled Trial Comparing Negative-Pressure Wound Therapy
   Versus Standard Open Wound Care After Surgical Excision
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE Pilonidal sinus disease; Vacuum therapy; Negative pressure wound
   therapy; Wound care; Wound size reduction; Surgical excision
ID VACUUM-ASSISTED CLOSURE; METAANALYSIS; SURGERY
AB BACKGROUND: Pilonidal sinus disease is associated with significant morbidity after surgical treatment with regard to wound healing. Recent case studies suggested that negative-pressure wound therapy as primary treatment following surgical excision may shorten the duration of wound healing.
   OBJECTIVE: The purpose of this randomized controlled trial was to evaluate the role of vacuum therapy in pilonidal sinus disease: negative-pressure wound therapy versus standard open wound care after surgical excision.
   METHODS: Patients were randomly assigned to either negative-pressure wound therapy for 2 weeks or standard open wound healing. The primary end point of the study was the time to complete wound healing. Secondary end points were visual analog scale score, wound size ratio at day 14 (ie, wound healing rate), time to resume daily activities, and recurrence within 6 months after wound closure.
   RESULTS: Forty-nine patients were included in the study: 24 patients were treated with vacuum therapy, and 25 patients underwent standard open wound care. Complete wound healing was achieved at a median of 84 days in the vacuum therapy group versus 93 days in control patients (p = 0.44). The wound size ratio was significantly lower in the vacuum therapy group (0.30 versus 0.57, p = 0.02), ie, higher wound healing rate in the first 2 weeks. There was no difference in visual analog scale scores and disease recurrence between both groups. The time to resume full daily activities after surgery was 27 days in the patients undergoing vacuum therapy and 29 days in the control patients (p = 0.92).
   LIMITATIONS: This study is limited by the small number of patients, the lack of blinding to patients and doctors, and the absence of patient quality-of-life evaluation.
   CONCLUSION: It is feasible to apply vacuum therapy in the treatment of pilonidal sinus disease, and it has a positive effect on wound size reduction in the first 2 weeks. However, there is no difference in time to complete wound healing and time to resume daily life activities.
C1 [Biter, L. Ulas; Beck, Guyon M. N.; Mannaerts, Guido H. H.; Stok, Myrte M.; van der Ham, Arie C.; Grotenhuis, Brechtje A.] St Franciscus Gasthuis, Dept Surg, NL-3004 BA Rotterdam, Netherlands.
C3 Franciscus Gasthuis
RP Biter, LU (通讯作者)，St Franciscus Gasthuis, Dept Surg, POB 10900, NL-3004 BA Rotterdam, Netherlands.
EM u.biter@sfg.nl
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NR 18
TC 57
Z9 69
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD DEC
PY 2014
VL 57
IS 12
BP 1406
EP 1411
DI 10.1097/DCR.0000000000000240
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA AT8BF
UT WOS:000345158100015
PM 25380007
DA 2026-07-24
ER

PT J
AU Okur, Ö
   Tabak, Z
   Can, M
   Boztas, AE
   Payza, AD
   Genisol, I
   Sencan, A
AF Okur, Ozkan
   Tabak, Zehra
   Can, Mehmet
   Boztas, Asya Eylem
   Payza, Ayse Demet
   Genisol, Incinur
   Sencan, Arzu
TI Negative pressure wound therapy in children: outcomes across a
   heterogeneous wound cohort
SO PEDIATRIC SURGERY INTERNATIONAL
LA English
DT Article
DE Negative-pressure wound therapy; Child; Wound healing; Surgical wound
   dehiscence; Burns
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; GAUZE; EXPERIENCE; INFANTS; TISSUE;
   FOAM
AB Purpose: Pediatric negative pressure wound therapy (NPWT) is widely used, but etiology- and age-informed real-world benchmarks are limited. We compared treatment burden and closure trajectories across pediatric wound categories. Methods: Retrospective single-center cohort of children (< 18 years) treated with NPWT for open wounds (2020-2025). Wounds were categorized as surgical (G1), acute (G2), chronic (G3), and burns (G4). NPWT was performed in accordance with an age-adapted institutional protocol in continuous mode; dressing changes were usually performed every 72 h. Results: 106 patients (median age 144 months, IQR 60-180) were included: G1 42, G2 22, G3 31, G4 11. Age distribution differed by group (p < 0.001), and instillation use varied (p = 0.014). Duration was longest in G3 (median 13 [8,-24] days) and shortest in G4 (median 6 [5,-9] days), while G1 and G2 were similar. Median cycle counts were similar across groups. Re-debridement was least frequent in G1. Definitive outcomes differed by etiology: primary closure predominated in G1, secondary healing in G3, and spontaneous closure in G4; grafting occurred mainly in burns, and flap reconstruction was rare. Conclusions: NPWT was feasible across heterogeneous pediatric wounds when used with a standardized, age-adapted approach. Etiology-specific differences in burden and outcomes inform expectations and support prospective multicenter evaluation.
C1 [Okur, Ozkan] Dr Behcet Uz Childrens Hosp, Pediat Surg, Ismet Kaptan Sokak, TR-35100 Konak, Izmir, Turkiye.
   [Tabak, Zehra; Can, Mehmet; Boztas, Asya Eylem; Payza, Ayse Demet; Genisol, Incinur] Univ Hlth Sci, Dr Behcet Uz Childrens Hosp, Pediat Surg, Izmir, Turkiye.
   [Sencan, Arzu] Univ Hlth Sci, Dr Behcet Uz Childrens Hosp, Izmir Fac Med, Pediat Surg, Izmir, Turkiye.
C3 Izmir Dr Behcet Uz Children's Disease & Surgery Training & Research
   Hospital; Izmir Dr Behcet Uz Children's Disease & Surgery Training &
   Research Hospital; University of Health Sciences Turkey; University of
   Health Sciences Turkey; Izmir Dr Behcet Uz Children's Disease & Surgery
   Training & Research Hospital
RP Okur, Ö (通讯作者)，Dr Behcet Uz Childrens Hosp, Pediat Surg, Ismet Kaptan Sokak, TR-35100 Konak, Izmir, Turkiye.
EM ozkanokurs@gmail.com; zehratabak8@gmail.com; mcan72@live.com;
   asyaeylem@gmail.com; demetpayza@gmail.com;
   imathncimathnurgenimathsol@msn.com; arzusencan71@yahoo.com.tr
RI sencan, arzu/HJJ-0979-2023; Okur, Özkan/AAV-7881-2021; CAN,
   MEHMET/AAV-7853-2021; genişol, incinur/HLG-2299-2023; BOZTAŞ, ASYA
   EYLEM/KIC-6267-2024
OI CAN, MEHMET/0000-0002-4263-0911; genişol, incinur/0000-0003-3843-5942;
   BOZTAŞ, ASYA EYLEM/0000-0002-5663-9394
CR Baharestani M, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00607.x
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0179-0358
EI 1437-9813
J9 PEDIATR SURG INT
JI Pediatr. Surg. Int.
PD MAR 6
PY 2026
VL 42
IS 1
AR 141
DI 10.1007/s00383-026-06370-1
PG 9
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA EX1WQ
UT WOS:001711868000003
PM 41790251
DA 2026-07-24
ER

PT J
AU Ravindhran, B
   Schafer, N
   Howitt, A
   Carradice, D
   Smith, G
   Chetter, I
AF Ravindhran, Bharadhwaj
   Schafer, Nicole
   Howitt, Annabel
   Carradice, Daniel
   Smith, George
   Chetter, Ian
TI Molecular mechanisms of action of negative pressure wound therapy: a
   systematic review
SO EXPERT REVIEWS IN MOLECULAR MEDICINE
LA English
DT Review
DE biomarkers; molecular mechanisms; negative-pressure wound therapy; wound
   care; wound healing
ID VACUUM-ASSISTED CLOSURE; EXPRESSION; STRESS; FIBRONECTIN; ANGIOGENESIS;
   RESPONSES; SWINE; FLUID
AB Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current evidence regarding the molecular mechanisms of action of NPWT. Medline, Embase, EBSCO databases and clinical trial registries were searched from inception to January 2023. Clinical studies, animal models or in-vitro studies that quantitatively or semi-quantitatively evaluated the influence of NPWT on growth factors, cytokine or gene-expression in the circulation or wound-bed were included. Risk of Bias assessment was performed using the RoBANS tool for non-randomized studies, the COCHRANE's Risk of Bias 2(ROB-2) tool for randomized clinical studies, OHAT tool for in-vitro studies or the SYRCLE tool for animal model studies. A descriptive summary was collated and the aggregated data is presented as a narrative synthesis. This review included 19 clinical studies, 11 animal studies and 3 in-vitro studies. The effects of NPWT on 43 biomarkers and 17 gene expressions were studied across included studies. NPWT stimulates modulation of numerous local and circulating cytokines and growth factor expressions to promote an anti-inflammatory profile. This is most likely achieved by downregulation of TNF alpha, upregulation of VEGF, TGF-beta and fibronectin.
C1 [Ravindhran, Bharadhwaj; Schafer, Nicole; Howitt, Annabel; Carradice, Daniel; Smith, George; Chetter, Ian] Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, England.
   [Ravindhran, Bharadhwaj] Univ York, Dept Hlth Sci, York, England.
C3 University of Hull; University of York - UK
RP Ravindhran, B (通讯作者)，Hull Royal Infirm, Acad Vasc Surg Unit, Kingston Upon Hull, England.; Ravindhran, B (通讯作者)，Univ York, Dept Hlth Sci, York, England.
EM bharadhwaj.ravindhran@nhs.net
RI ; Carradice, Daniel/AFN-0257-2022; Ravindhran, Bharadhwaj/IQU-6793-2023
OI Schafer, Nicole/0009-0000-9940-1039; Smith, George/0000-0002-8085-0886;
   chetter, ian/0000-0002-2566-6859; Carradice, Daniel/0000-0002-7733-3925;
   Ravindhran, Bharadhwaj/0000-0003-0778-2191
FU The authors would like to thank the Academic vascular Surgical Unit at
   Hull Royal Infirmary for their support with this article.
FX The authors would like to thank the Academic vascular Surgical Unit at
   Hull Royal Infirmary for their support with this article.
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NR 71
TC 16
Z9 18
U1 2
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1462-3994
J9 EXPERT REV MOL MED
JI Expert Rev. Mol. Med.
PD OCT 19
PY 2023
VL 25
AR e29
DI 10.1017/erm.2023.24
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA U8TD3
UT WOS:001087461800001
PM 37853784
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Anagnostakos, K
   Mosser, P
AF Anagnostakos, K.
   Mosser, P.
TI Negative pressure wound therapy in the management of postoperative
   infections after musculoskeletal tumour surgery
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; infections; musculoskeletal tumour
   surgery
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE SARCOMA; COMPLICATIONS;
   RADIOTHERAPY; EXTREMITY; STATE
AB Objective: The aim of the present retrospective study was to report on the effectiveness of the negative pressure wound therapy (NPWT) in the treatment of infected wounds after musculoskeletal tumour surgery.
   Method: A total of 12 patients (10 male, 2 female, mean age 44.9 years with 9 early and 3 late infections) were included in the study. Patient parameters measured include age, gender, tumour diagnosis and localisation, pathogen organism, foam used, pressure height and modus, number of NPWT dressings changes, total duration of NPWT, need for secondary wound closure, length of hospitalisation, complications, and follow-up.
   Results: The NPWT dressings were changed on average 6.7 (SD +/- 6.9) times after a mean duration of 5.6 (SD +/- 2.4) days. The total duration of NPWT was 37.7 (SD +/- 32.9)days. The mean hospital stay was 77.5 (SD +/- 58.8) days. In 7 out of 12 cases, a split-thickness skin graft transplantation was performed. In these cases, no seroma or hematoma formation beneath the skin graft could be observed. At a mean follow-up 39.2 (range: 9-73) months, no reinfection or infection persistence was apparent.
   Conclusion: NPWT can be of valuable assistance in the treatment of infected wounds following musculoskeletal tumour surgery. The patients should be informed about the long treatment period.
C1 [Anagnostakos, K.; Mosser, P.] Univ Hosp Saarland, Dept Orthopaed Surg, Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Hosp Saarland, Dept Orthopaed Surg, Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
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NR 29
TC 5
Z9 5
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2014
VL 23
IS 4
BP 191
EP 197
DI 10.12968/jowc.2014.23.4.191
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AE3AV
UT WOS:000333848600006
PM 24762382
DA 2026-07-24
ER

PT J
AU Stannard, JP
   Robinson, JT
   Anderson, ER
   McGwin, G
   Volgas, DA
   Alonso, JE
AF Stannard, James P.
   Robinson, James T.
   Anderson, E. Ratcliffe
   McGwin, Gerald, Jr.
   Volgas, David A.
   Alonso, Jorge E.
TI Negative pressure wound therapy to treat hematomas and surgical
   incisions following high-energy trauma
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article
DE negative pressure wound therapy; hematoma; surgical incisions;
   high-energy trauma
ID VACUUM-ASSISTED CLOSURE; TIBIAL PLATEAU FRACTURES; WIRE EXTERNAL
   FIXATION; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; DEGLOVING
   INJURIES; SKIN-GRAFTS; MANAGEMENT; DRESSINGS; SYSTEM
AB Purpose: To evaluate the use of negative pressure wound therapy (NPWT) to augment healing of surgical incisions and hematomas after high-energy trauma.
   Materials: This study is a prospective randomized evaluation of NPWT in trauma patients, randomizing patients with draining hematomas to either a pressure dressing (group A) or a VAC (group B). Additionally, patients with calcaneus, pilon, and high-energy tibial plateau fractures were randomized to either a standard postoperative dressing or a VAC over the sutures.
   Results: There were 44 patients randomized into the hematoma study. Group A drained a mean of 3.1 days, compared with only 1.6 days for group B. This difference was significant (p = 0.03). The infection rate for group A was 16%, compared with 8% in group B. An additional 44 patients have been randomized into the fracture study. Again, a significant difference (p = 0.02) was present when comparing drainage in group A (4.8 days) and group B (1.8 days). No significant difference was present at current enrollment for infection or wound breakdown.
   Discussion: NPWT has been used on many complex traumatic wounds. Potential mechanisms of action include angiogenesis, increased blood flow, and decreased interstitial fluid. This ongoing randomized study has demonstrated decreased drainage and improved wound healing following both hematomas and severe fractures.
C1 Univ Alabama Birmingham, Div Orthopaed Surg, Dept Surg, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Stannard, JP (通讯作者)，Univ Alabama Birmingham, Div Orthopaed Surg, Dept Surg, 509 Med Educ Bldg,619 S 19th St, Birmingham, AL 35294 USA.
EM James.Stannard@ortho.uab.edu
OI Stannard, James P/0000-0001-8467-6494
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NR 44
TC 236
Z9 282
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5282
EI 1529-8809
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD JUN
PY 2006
VL 60
IS 6
BP 1301
EP 1306
DI 10.1097/01.ta.0000195996.73186.2e
PG 6
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 053TR
UT WOS:000238328700032
PM 16766975
DA 2026-07-24
ER

PT J
AU Ahearn, C
AF Ahearn, Cindy
TI Intermittent Negative Pressure Wound Therapy and Lower Negative
   Pressures - Exploring the Disparity between Science and Current
   Practice: A Review of the Literature
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE review; intermittent negative pressure wound therapy; low pressure;
   regional blood flow; granulation tissue
ID VACUUM-ASSISTED CLOSURE; CELL-GROWTH; BLOOD-FLOW; DEVICES
AB Negative pressure wound therapy (NPWT) is used to treat a wide and growing range of problematic acute and chronic wounds. Continuous therapy delivered at -125 mm Hg has been routinely recommended, despite consistent research findings suggesting potential advantages to the use of lower pressures and intermittent therapy. To enhance understanding and document the disparity between the body of NPWT science and current practice with respect to negative pressure levels and modes of therapy, a search of the English-language literature from June 1989 through May 2009 was conducted. Thirty-six publications found to contain directly relevant information (in vitro, in vivo, and clinical data) were examined. While lower negative pressures and intermittent therapy were associated in earlier studies with improved microvascular blood flow in porcine wound models and with reduced pain in patients, early system shortcomings discourage adoption of intermittent therapy. Subsequent preclinical studies confirmed the beneficial effects of intermittent therapy compared to continuous therapy on blood flow and granulation tissue formation and lower pressures (-75 mm Hg or -100 mm Hg) compared to higher pressure (-125 mm Hg) on soft tissue blood flow. Considering the available preclinical evidence, reported patient pain, and common use of high-pressure continuous NPWT in clinical practice, high-quality randomized controlled clinical trials must be conducted to help clinicians optimize care.
C1 Prospera, Clin Serv, Ft Worth, TX 76107 USA.
RP Ahearn, C (通讯作者)，Prospera, Clin Serv, 2831 Bledsoe St, Ft Worth, TX 76107 USA.
EM cahearn@prospera-npwt.com
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NR 36
TC 23
Z9 24
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2009
VL 55
IS 6
BP 22
EP +
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 463BZ
UT WOS:000267404700006
PM 19564670
DA 2026-07-24
ER

PT J
AU Vassallo, IM
   Formosa, C
AF Vassallo, Ian Mario
   Formosa, Cynthia
TI Comparing Calcium Alginate Dressings to Vacuum-assisted Closure: A
   Clinical Trial
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE diabetic ulcers; calcium alignate; negative pressure; lower extremity
   wounds; wound healing
ID PRESSURE WOUND THERAPY; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   DISEASE; NEGATIVE-PRESSURE; HIGH-RISK; ULCERS; MULTICENTER; MANAGEMENT;
   ULCERATION; GAUZE
AB Introduction. Several treatment modalities and protocols for arterial wound ulcers are available; however, little consensus exists on which treatment modality provides the best results. The present study sought to compare and evaluate the clinical efficacy of vacuum-assisted closure wound therapy to calcium alginate dressings in the treatment of neuroischemic diabetic foot ulceration. Material and Methods. A single-center quasi-experimental matched subject clinical trial was conducted on 30 subjects living with type 2 diabetes and presenting with a newly diagnosed neuroischemic foot ulceration. Subjects were divided into 2 groups. Group A (n = 15) underwent negative pressure wound therapy and Group B (n = 15) underwent treatment using calcium alginate dressings. Ulcer area and depth were measured during the trial. Results. Both negative pressure therapy and calcium alginate dressings were effective in reducing the surface area and depth of ulcers (P = 0.0001). However, negative pressure was 3.2 times more effective in reducing surface area and 3.78 times more effective in reducing depth of ulcers when compared to calcium alginate (P = 0.0001). Conclusion. Vacuum-assisted closure should be considered as the treatment of choice for neuroischemic ulceration owing to its advantages in reducing surface area and depth when compared to calcium alginate dressings. Improved care could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications.
C1 [Vassallo, Ian Mario] Dept Hlth, Valletta, Malta.
   [Formosa, Cynthia] Univ Malta, Fac Hlth Sci, Msida, Malta.
C3 University of Malta
RP Formosa, C (通讯作者)，Univ Malta, Fac Hlth Sci, Msida, Malta.
EM Cynthia.formosa@um.edu.mt
RI ; Formosa, Cynthia/AAC-3182-2020
OI , Abda Ali/0009-0003-8852-5222; Formosa, Cynthia/0000-0002-4251-1621
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   Ubbink DT, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001898.pub2
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NR 45
TC 14
Z9 17
U1 0
U2 14
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2015
VL 27
IS 7
BP 180
EP 190
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CO0CZ
UT WOS:000358819000005
PM 26192736
DA 2026-07-24
ER

PT J
AU Sergeenko, MO
   Korostelev, YM
   Shikhaleva, GN
   Savin, MD
   Filatov, YE
   Ryabykh, OS
AF Sergeenko (Pavlova), M. Olga
   Korostelev, Yu. Michail
   Shikhaleva, G. Natalia
   Savin, M. Dmitry
   Filatov, Yu. Egor
   Ryabykh, O. Sergey
TI Negative pressure wound therapy in cases of spinal surgery and exposed
   dura: a case-based review
SO CHILDS NERVOUS SYSTEM
LA English
DT Review
DE Spinal dysraphism; Myelomeningocele; Negative pressure wound therapy;
   Vacuum-assisted closure
ID CEREBELLAR HEMORRHAGE; MYELOMENINGOCELE; CHILDREN; KYPHECTOMY; KYPHOSIS;
   COMPLICATION; IMPROVEMENT; REPAIR; ULCERS
AB Purpose Study of negative pressure wound therapy (NPWT) safety for patients with intraoperative exposure of the dura. Methods We analyzed the literature on the NPWT usage after spinal surgery in patients with exposure of the dura. We also described our experience of NPWT in 3 pediatric patients with spinal dysraphism. Due to the peculiarities of the anatomy (spina bifida), all of these patients had dural sac exposure during spinal surgery. Results The reasons for NPWT in all three cases were different. In the first patient with segmental spinal dysgenesis, surgery was complicated by extensive postoperative wound necrosis and the formation of soft tissue deficiency. The second patient with post-myelomeningocele kyphosis had a deficiency of soft tissues during spinal surgery due to a large bedsore at the apex of the deformity. And in the third patient also with post-myelomeningocele kyphosis, NPWT was applied with surgical site infection. In all three cases, NPWT was used when the dura was exposed, without complications and with satisfactory results. The observation period for the patients was 3 years, 2.5 years, and 2 years, respectively. Conclusions The usage of NPWT in cases of wound complications in the spinal surgery may be a useful option, which allows saving implants. NPWT is not contraindicated in cases of intraoperative dural exposure if there are no signs of cerebrospinal fluid (CSF) leak.
C1 [Sergeenko (Pavlova), M. Olga; Savin, M. Dmitry; Filatov, Yu. Egor; Ryabykh, O. Sergey] Ilizarov Ctr, Div Spinal Surg, 6 M Ulyanova St, Kurgan 640014, Russia.
   [Korostelev, Yu. Michail; Shikhaleva, G. Natalia] Ilizarov Ctr, Div Plast Surg & Reconstruct, Kurgan, Russia.
C3 Ilizarov National Scientific Center for Restorative Traumatology &
   Orthopaedics; Ilizarov National Scientific Center for Restorative
   Traumatology & Orthopaedics
RP Sergeenko, MO (通讯作者)，Ilizarov Ctr, Div Spinal Surg, 6 M Ulyanova St, Kurgan 640014, Russia.
EM pavlova.neuro@mail.ru; savindm81@mail.ru; filatov@ro.ru
RI Ryabykh, Sergey/I-4554-2018; /N-9689-2018; /O-3108-2018
OI Ryabykh, Sergey/0000-0002-8293-0521; 
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NR 32
TC 3
Z9 5
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0256-7040
EI 1433-0350
J9 CHILD NERV SYST
JI Childs Nerv. Syst.
PD OCT
PY 2021
VL 37
IS 10
BP 2975
EP 2981
DI 10.1007/s00381-021-05302-9
EA JUL 2021
PG 7
WC Clinical Neurology; Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics; Surgery
GA WG1YZ
UT WOS:000679008300001
PM 34312707
DA 2026-07-24
ER

PT J
AU Costello, JP
   Amling, JK
   Emerson, DA
   Peer, SM
   Afflu, DK
   Zurakowski, D
   Jonas, RA
   Nath, DS
AF Costello, J. P.
   Amling, J. K.
   Emerson, D. A.
   Peer, S. M.
   Afflu, D. K.
   Zurakowski, D.
   Jonas, R. A.
   Nath, D. S.
TI Negative pressure wound therapy for sternal wound infections following
   congenital heart surgery
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; sternal wound infection; congenital
   heart surgery; mediastinitis
ID VACUUM-ASSISTED CLOSURE; POSTOPERATIVE MEDIASTINITIS; CARDIAC-SURGERY;
   MANAGEMENT
AB Objective: This study examines the efficacy of a comprehensive, multidisciplinary wound management team and negative pressure wound therapy (NPWT) for the treatment of sternal wound infections in congenital heart surgery patients.
   Method: A single-institution retrospective review of all congenital heart surgery patients with postoperative sternal wound infections who were treated with NPWT was performed. Patients were evaluated based on (a) whether NPWT occurred before or after the establishment of a multidisciplinary wound management team, and (b) whether NPWT was initiated early (within 2 days) or late (greater than 2 days) after diagnosis of a sternal wound infection.
   Results: The median duration of NPWT was 12 days (range 2-50 days). NPWT was successfully initiated in patients as young as 15 days of age. There was a trend toward shorter duration of both NPWT and antibiotic use following (a) the implementation of the multidisciplinary wound management team, and (b) in patients with early use of NPWT; however, these results did not achieve statistical significance.
   Conclusion: NPWT can be successfully utilised in congenital heart surgery patients, including young neonates, for the treatment of sternal wound infections. The trends observed in the reduction of wound therapy duration and antibiotic duration with early implementation of negative pressure therapy and multidisciplinary wound management require further investigation to verify their clinical efficacy in patient care.
C1 [Costello, J. P.; Emerson, D. A.; Peer, S. M.; Afflu, D. K.; Jonas, R. A.; Nath, D. S.] Childrens Natl Hlth Syst, Div Cardiovasc Surg, Washington, DC USA.
   [Costello, J. P.] Childrens Natl Hlth Syst, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC USA.
   [Amling, J. K.] Childrens Natl Hlth Syst, Wound & Surg Airway Program, Washington, DC USA.
   [Zurakowski, D.] Harvard Univ, Sch Med, Dept Anaesthesia, Boston Childrens Hosp, Boston, MA 02115 USA.
   [Zurakowski, D.] Harvard Univ, Sch Med, Dept Surg, Boston Childrens Hosp, Boston, MA 02115 USA.
C3 Children's National Health System; Children's National Health System;
   Children's National Health System; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Costello, JP (通讯作者)，Childrens Natl Hlth Syst, Div Cardiovasc Surg, Washington, DC USA.
EM dnath@childrensnational.org
RI ; Peer, Syed/ABD-8308-2020
OI Emerson, Dominic/0000-0001-5728-0152; Afflu, Derek/0000-0002-8146-029X;
   Peer, Syed/0000-0003-0859-2496
CR Al-Sehly AA, 2005, ANN THORAC SURG, V80, P2314, DOI 10.1016/j.athoracsur.2005.05.035
   Berg LT, 2013, SCAND J SURG, V102, P3, DOI 10.1177/145749691310200102
   Bütter A, 2006, J PEDIATR SURG, V41, P940, DOI 10.1016/j.jpedsurg.2006.01.061
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NR 15
TC 14
Z9 17
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2014
VL 23
IS 1
BP 31
EP 36
DI 10.12968/jowc.2014.23.1.31
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 286GX
UT WOS:000329456100005
PM 24406541
DA 2026-07-24
ER

PT J
AU Mari, W
   Younes, S
   Naqvi, J
   Abu Issa, A
   Oroszi, TL
   Cool, DR
   Travers, JB
   Simman, R
AF Mari, Walid
   Younes, Sara
   Naqvi, Jaree
   Abu Issa, Abdelfattah
   Oroszi, Terry L.
   Cool, David R.
   Travers, Jeffrey B.
   Simman, Richard
TI Use of a Natural Porcine Extracellular Matrix With Negative Pressure
   Wound Therapy Hastens the Healing Rate in Stage 4 Pressure Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE chronic wound; Oasis Ultra; extracellular matrix; dressing; biological
   wound matrices; pressure ulcer; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Introduction. Chronic wounds are physically debilitating and painful and are responsible for the addition of more than $25 billion annually in health care costs in the United States. Extracellular matrix (ECM) replacements have been demonstrated to aid in wound healing by providing an optimal environment to facilitate the healing process. Objective. This study examines the healing rates of stage 4 pressure ulcers using combination of a commercially available porcine-based wound matrix dressing alongside negative pressure wound therapy (NPWT) versus using NPWT alone. Materials and Methods. Patients were randomized to receive either the matrix plus NPWT (study) or NPWT alone (control) for stage 4 sacral pressure ulcer treatment. Wounds were photographed and measured weekly. The experimental group had their ECM dressings changed every other week and their NPWT changed twice weekly. Results. A total of 16 patients, 8 study and 8 control, completed this study. After the 12-week study period, the average control patient healing rate was 45.79% as compared with the 89.98% healing rate in the study group (P<.01). The difference in healing rate between control and study patients was optimal by 12 weeks. Conclusions. These studies suggest that ECM dressings may be a promising adjunctive treatment option for stage 4 pressure ulcers.
C1 [Mari, Walid; Younes, Sara; Naqvi, Jaree; Abu Issa, Abdelfattah; Oroszi, Terry L.; Cool, David R.; Travers, Jeffrey B.; Simman, Richard] Wright State Univ, Dept Pharmacol & Toxicol, Boonshoft Sch Med, Dayton, OH 45435 USA.
C3 University System of Ohio; Wright State University Dayton
RP Simman, R (通讯作者)，ProMedica Toledo Hosp, Jobst Vasc Inst, 2109 Hughes Dr,Suite 400, Toledo, OH 43606 USA.
EM richard.simmanmd@promedica.org
RI Travers, Jeffrey/KLE-3517-2024
OI Travers, Jeffrey/0000-0001-7232-1039
CR AbouIssa A, 2015, WOUNDS, V27, P313
   [Anonymous], 2016, NPUAP Pressure Injury Stages
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   Hodde JP, 2015, J WOUND CARE, V14, P23
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   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Turner NJ, 2015, ADV WOUND CARE, V4, P490, DOI 10.1089/wound.2014.0604
NR 15
TC 17
Z9 21
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2019
VL 31
IS 5
BP 117
EP 122
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IV4YS
UT WOS:000484279000006
PM 30990777
DA 2026-07-24
ER

PT J
AU Aydogdu, O
   Tuncel, U
   Gümüs, M
   Kurt, A
   Oztürk, N
   Aksakal, IA
   Güzel, N
   Çelik, UR
   Erkorkmaz, U
AF Aydogdu, Oguzhan
   Tuncel, Umut
   Gumus, Murat
   Kurt, Alper
   Ozturk, Nuray
   Aksakal, Ibrahim Alper
   Guzel, Nizamettin
   Celik, Ugur Recep
   Erkorkmaz, Unal
TI Zinc-coated Foam With Negative Pressure Wound Therapy in the Treatment
   of Challenging Wounds: A New Alternative Interface Material
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE zinc; interface material; wounds; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ISCHEMIA-REPERFUSION; CLINICAL-EVALUATION; SKIN
   WOUNDS; IN-VIVO; OXIDE; INJURY; DEVICE; TISSUE; RATS
AB Objective. The aim of the study was to present the authors' clinical observations on zinc-coated foam with negative pressure wound therapy (NPWT). MaterialS and Methods. Ninety-four consecutive patients treated with zinc-coated foam with VAC therapy were retrospectively reviewed. Nonhealing wounds of at least 6 months duration with high to moderate exudate that required open wound management to secondary intervention were included in this study. The evaluation criteria consisted of the measurement of wound surface area, length Of overall treatment time, and a clinical observation of granulation tissue formation in the wound bed. Results. In all wounds, there was a significant decrease of the wound surface area, and wound exudate was obtained at the end Of the treatment. There was a statistically significant difference between pretreatment and posttreatment measurements (P < 0.05). In all wounds, granulation tissue formation was clinically observed by day 6. Of the 94 wounds, 72 were surgically closed and 22 healed secondarily. The follow-up period averaged 12 months, and it was uneventful with no sign of complications from the use of the material. Conclusion. The results of the retrospective study demonstrate zinc-coatedfoam with NPWT can be safely used as an effective and alternative interface material in the treatment of challenging wounds.
C1 [Aydogdu, Oguzhan; Tuncel, Umut; Gumus, Murat; Ozturk, Nuray; Aksakal, Ibrahim Alper; Guzel, Nizamettin] Samsun Educ & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, TR-55100 Samsun, Turkey.
   [Kurt, Alper] Samsun State Hosp, Dept Plast Reconstruct & Aesthet Surg, Samsun, Turkey.
   [Celik, Ugur Recep] Tokat State Hosp, Dept Plast Reconstruct & Aesthet Surg, Tokat, Turkey.
   [Erkorkmaz, Unal] Sakarya Univ, Fac Med, Dept Biostat, Sakarya, Turkey.
C3 Samsun Training & Research Hospital; Samsun Gazi State Hospital; Tokat
   State Hospital; Sakarya University
RP Tuncel, U (通讯作者)，Samsun Educ & Res Hosp, Dept Plast Reconstruct & Aesthet Surg, TR-55100 Samsun, Turkey.
EM drumuttuncel@gmail.com
RI Erkorkmaz, Ünal/AAA-4241-2022; Aksakal, İbrahim Alper/F-5211-2015;
   /AAA-9449-2020; TUNCEL, Umut/P-3185-2015
OI Erkorkmaz, Ünal/0000-0002-8497-4704; 
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NR 46
TC 0
Z9 0
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2016
VL 28
IS 11
BP 395
EP 403
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA ED7DL
UT WOS:000389015800005
PM 27589360
DA 2026-07-24
ER

PT J
AU Scalise, A
   Tartaglione, C
   Bolletta, E
   Calamita, R
   Nicoletti, G
   Pierangeli, M
   Grassetti, L
   Di Benedetto, G
AF Scalise, Alessandro
   Tartaglione, Caterina
   Bolletta, Elisa
   Calamita, Roberto
   Nicoletti, Giovanni
   Pierangeli, Marina
   Grassetti, Luca
   Di Benedetto, Giovanni
TI The enhanced healing of a high-risk, clean, sutured surgical incision by
   prophylactic negative pressure wound therapy as delivered by Prevena™
   Customizable™ : cosmetic and therapeutic results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Surgical incision; Surgical wound
   infection; Wound healing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW; SITE
   INFECTIONS; MANAGEMENT; HEALTH; DEHISCENCE
AB According to the literature, incisional closure complications may range from postoperative surgical site infections, representing 17-22% of health care-associated infections, surgical wound dehiscence and formation of haematomas or seromas, and can lead to delayed or impaired incision healing. These kinds of situations are more common when wounds are closed under tension or in specific patient morbidities. Obesity, in particular, is associated with an impaired blood flow to tissues, predisposing the patient to increased risk of wound complications by various mechanisms. Incisional complications can become relevant economic burdens for health care systems because of an increase in the average length of hospital stay and readmissions, and additional medical and surgical procedures. Thus, a preventive therapy may have a critical role in the management of healing. Negative pressure wound therapy (NPWT) technology as delivered by Prevena Customizable (Kinetic Concepts Inc., San Antonio, TX) has recently been the focus of a new investigation, as a prophylactic measure to prevent complications via immediate postoperative application in high-risk, clean, closed surgical incisions. The authors present a 62-year-old class II obese female, who underwent bilateral inguinal dermolipectomy. Prophylactic NPWT as delivered by Prevena was performed successfully over surgical incisions. Cosmetic and therapeutic results are shown.
C1 [Scalise, Alessandro; Tartaglione, Caterina; Bolletta, Elisa; Calamita, Roberto; Pierangeli, Marina; Grassetti, Luca; Di Benedetto, Giovanni] Univ Politecn Marche, Dept Plast & Reconstruct Surg, I-60126 Ancona, Italy.
   [Nicoletti, Giovanni] Univ Pavia, Dept Plast & Reconstruct Surg, I-27100 Pavia, Italy.
   [Nicoletti, Giovanni] Univ Pavia, Dept Diagnost Paediat Clin & Surg Sci, I-27100 Pavia, Italy.
C3 Marche Polytechnic University; University of Pavia; University of Pavia
RP Scalise, A (通讯作者)，Univ Politecn Marche, Dept Plast & Reconstruct Surg, Via Conca 71, I-60126 Ancona, Italy.
EM a.scalise@univpm.it
RI ; Nicoletti, Giovanni/Q-4356-2019
OI Grassetti, Luca/0000-0002-8856-7997; Nicoletti,
   Giovanni/0000-0002-1507-4067; Scalise, Alessandro/0000-0002-9198-4943
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NR 49
TC 23
Z9 27
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 218
EP 223
DI 10.1111/iwj.12370
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400017
PM 25234139
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Rabel, T
   Bonnot, PE
   Hadeedi, O
   Kepenekian, V
   Bernard, L
   Friggeri, A
   Glehen, O
   Passot, G
AF Rabel, Thomas
   Bonnot, Pierre-Emmanuel
   Hadeedi, Omar
   Kepenekian, Vahan
   Bernard, Lorraine
   Friggeri, Arnaud
   Glehen, Olivier
   Passot, Guillaume
TI Negative-Pressure Wound Therapy for Open Abdomen in Surgical
   Reintervention after Curative Surgery of Peritoneal Malignancy Increases
   the Risk of Recurrence
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE abdomen; cancer; cytoreduction; emergency surgery; laparostomy;
   malignancy; negative-pressure wound therapy; peritoneal carcinomatosis;
   recurrence; surgery
ID VACUUM-ASSISTED CLOSURE
AB OBJECTIVE: Negative-pressure wound therapy for open abdomen (NPWTOA) helps reduce the risk of abdominal compartment syndrome. However, the risk of recurrence of cancer is unclear when NPWTOA is applied after oncologic resection. The aim of this study was to evaluate the effects of NPWTOA used for major complications on patients treated with cytoreductive surgery for peritoneal malignancy (PM). METHODS: All patients who underwent an NPWTOA after potentially curative surgery of PM in a single institution were included. These patients were pair matched 1:3 on the Peritoneal Cancer Index, completeness of cytoreduction using a scoring index, and PM origin with patients who underwent surgical reintervention without NPWTOA after curative surgery of PM. Survival among the two groups was compared using the Kaplan-Meier method. RESULTS: Between 2011 and 2017, among 719 curative surgeries for PM, 13 patients underwent an NPWTOA after surgical reintervention. Researchers paired 9 of these patients to 27 others without NPWTOA after surgical reintervention. Median overall survival was 4.8 and 35 months (P = .391), and median disease-free survival was 4.0 and 13.9 months (P = .022) for the NPWTOA and non-NPWTOA groups, respectively. CONCLUSIONS: The use of the NPWTOA during surgical reintervention after curative surgery for PM may increase the risk of early recurrence.
C1 [Rabel, Thomas; Bonnot, Pierre-Emmanuel; Hadeedi, Omar; Kepenekian, Vahan; Bernard, Lorraine] Hosp Civils Lyon, Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
   [Friggeri, Arnaud] Hosp Civils Lyon, Dept Biostat, Lyon, France.
   [Glehen, Olivier; Passot, Guillaume] Hop Lyon Sud, Dept Anesthesiol & Intens Care, Lyon, France.
   [Glehen, Olivier; Passot, Guillaume] Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
C3 CHU Lyon; CHU Lyon; CHU Lyon; CHU Lyon
RP Rabel, T (通讯作者)，Hosp Civils Lyon, Hosp Lyon Sud, Dept Visceral & Oncol Surg, Lyon, France.
RI Passot, Guillaume/K-6271-2012; Friggeri, Arnaud/AAE-7644-2020;
   Kepenekian, Vahan/AFF-8361-2022
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NR 25
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV
PY 2023
VL 36
IS 11
BP 6
EP 6
DI 10.1097/ASW.0000000000000018
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GD2G8
UT WOS:001150656300006
PM 37861668
DA 2026-07-24
ER

PT J
AU Daar, DA
   Wirth, GA
   Evans, GRD
   Carmean, M
   Gordon, IL
AF Daar, David A.
   Wirth, Garrett A.
   Evans, Gregory R. D.
   Carmean, Melissa
   Gordon, Ian L.
TI The Bagautdinov dressing method: negative pressure wound therapy in a
   patient with an allergy to acrylate adhesive
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Adhesive allergy; Bagautdinov dressing; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; CONTACT-DERMATITIS; MULTICENTER; ULCERS
AB Current embodiments of negative pressure wound therapy (NPWT) create a hermetically sealed chamber at the surface of the body using polyurethane foam connected to a vacuum pump, which is then covered by a flexible adhesive drape. Commercially available NPWT systems routinely use flexible polyethylene films that have a sticky side, coated with the same acrylate adhesives used in other medical devices such as ECG leads and grounding pads. Severe reactions to the acrylate adhesives in these other devices, although uncommon, have been reported. We describe the case of a 63-year-old woman with an intractable leg ulcer resulting from external-beam radiotherapy (XRT). Treatment with a standard commercial NPWT system induced severe inflammation of the skin in direct contact with drape adhesive. We successfully administered prolonged, outpatient NPWT to the patient using an alternative method (first described by Bagautdinov in 1986), using plain polyethylene film and petrolatum. The necessary hermetic seal is achieved by smearing the skin with petrolatum before applying the polyethylene film and activating the vacuum pump. The Bagautdinov method is a practical solution to the problem of adapting NPWT to patients with contact sensitivity or skin tears related to the adhesive compounds in the flexible drapes. Its use of a circumferential elastic wrap to maintain constant pressure on the seal probably limits the Bagautdinov technique to the extremities.
C1 [Daar, David A.; Wirth, Garrett A.; Evans, Gregory R. D.] Univ Calif Irvine, Aesthet & Plast Surg Inst, Irvine, CA USA.
   [Wirth, Garrett A.; Carmean, Melissa] Univ Calif Irvine, Burn & Wound Clin, Rehabilitat Serv, Irvine, CA USA.
   [Wirth, Garrett A.; Gordon, Ian L.] Long Beach Vet Affairs Hlth Care Syst, Dept Surg, Long Beach, CA 90822 USA.
   [Wirth, Garrett A.; Gordon, Ian L.] Univ Calif Irvine, Dept Surg, Irvine, CA 92717 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Long Beach Healthcare System; University of California System;
   University of California Irvine
RP Gordon, IL (通讯作者)，Long Beach Vet Affairs Hlth Care Syst, Dept Surg, Long Beach, CA 90822 USA.
EM ian.gordon@va.gov
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NR 29
TC 7
Z9 7
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2017
VL 14
IS 1
BP 198
EP 202
DI 10.1111/iwj.12589
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EJ0RX
UT WOS:000392919100029
PM 27212250
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Liu, J
   Morykwas, MJ
   Argenta, LC
   Wagner, WD
AF Liu, Jie
   Morykwas, Michael J.
   Argenta, Louis C.
   Wagner, William D.
TI Development of a biodegradable foam for use in negative pressure wound
   therapy
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE negative pressure wound therapy; poly(epsilon-caprolactone); foam; foam
   dressing; biodegradable polymer
ID VACUUM-ASSISTED CLOSURE; IN-VITRO; DEGRADATION; SCAFFOLDS
AB Treatment of wounds using negative pressure wound therapy (NPWT) uses a nondegradable polyvinyl alcohol (PVA) foam in the application of negative pressures typically for 1-3 days. The purpose of this study was to construct and test biodegradable poly(e-caprolactone) (PCL) foam as a substitute for the PVA foam. Such a foam would be left within the wound until healing was achieved and form a biodegradable matrix into which tissue would grow. The use of such foam would obviate the need for any serial foam changes and a final foam removal, thus making patient care much easier and more economical. PCL foams were prepared by salt leaching and phase separation. Morphological and mechanical properties of the foams were characterized and compared to PVA foam. PCL and PVA foams were tested on the uncut surface of a pig liver maintained in a hydration chamber continuously replenished with saline under the conditions of negative pressure of 50 mm Hg for 72 h. The results demonstrated that PCL foam made from phase separation had the similar properties and function as the PVA foam. The results demonstrate that PCL foam is an appropriate substitute for currently used nondegradable PVA foam in NPWT applications. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 98B: 316-322, 2011.
C1 [Liu, Jie; Morykwas, Michael J.; Argenta, Louis C.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Wound Repair Nanomed Res Program, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Wound Repair Nanomed Res Program, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM wwagner@wfubmc.edu
OI Morykwas, Michael/0009-0001-5547-5172
CR Aparna S., 2005, BIOMATERIALS, V26, P5500
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NR 24
TC 12
Z9 13
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2011
VL 98B
IS 2
BP 316
EP 322
DI 10.1002/jbm.b.31854
PG 7
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 789NN
UT WOS:000292522300015
PM 21648059
DA 2026-07-24
ER

PT J
AU Suludere, MA
   Malone, M
   Siah, MC
   Tarricone, A
   Coye, TL
   Najafi, B
   Lavery, LA
AF Suludere, Mehmet A.
   Malone, Matthew
   Siah, Michael C.
   Tarricone, Arthur
   Coye, Tyler L.
   Najafi, Bijan
   Lavery, Lawrence A.
TI The Infected Diabetic Foot: Does Negative Pressure Wound Therapy with
   Irrigation Reduce Bioburden and Improve Wound Healing?
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article; Early Access
DE negative pressure wound therapy; irrigation; polyhexamethylene
   biguanide; diabetic foot infection; diabetic foot wound
ID VACUUM-ASSISTED CLOSURE; BACTERIAL LOAD; INSTILLATION; AMPUTATION;
   OUTCOMES; BIOFILM; IMPACT; SALINE
AB The aim of this study was to compare the microbial loads of patients with diabetic foot infections treated with negative pressure wound therapy (NPWT) with and without irrigation with polyhexamethylene biguanide (NPWTi-P). This is a post hoc analysis of combined data of two randomized clinical trials. We evaluated people with diabetes treated with moderate and severe diabetic foot infections that required surgery. Tissue specimens were obtained after the initial surgery and following a second planned return to the operating room after 48-72 h of NPWT or NPWTi-P, prior to the second surgery. We used quantitative polymerase chain reaction (qPCR) to determine the total microbial loads (Log10 16S copies per gram of tissue). There was no difference in mean quantitative bacterial cultures among patients that received NPWT and NPWTi-P (before first surgery Log10: NPWT = 6.4 +/- 1.8, NPWTi-P = 7.5 +/- 1.7 vs before second surgery Log10: NPWT = 6.7 +/- 1.8, NPWTi-P = 7.6 +/- 1.9 p = .12). There was no difference in wound healing (59.5% vs 50.0%, p = .51) or time to heal (127 +/- 109.3 vs 143 +/- 95.9), p = .71). There were fewer re-infections in people that received traditional NPWT (28.6% vs 56.3%, p = .05).Level of Clinical Evidence: Level 1.
C1 [Suludere, Mehmet A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd F4 124, Dallas, TX 75390 USA.
   [Malone, Matthew] Western Sydney Univ, Sch Med, Infect Dis & Microbiol, Sydney, Australia.
   [Siah, Michael C.] Univ Texas Southwestern Med Ctr, Dept Surg, Dallas, TX USA.
   [Siah, Michael C.] Univ Texas Dallas, Dept Bioengn, Richardson, TX USA.
   [Tarricone, Arthur] Univ Texas Hlth Sci Ctr, Dept Orthopaed Surg, San Antonio, TX USA.
   [Coye, Tyler L.; Najafi, Bijan] Baylor Coll Med, Dept Surg, Houston, TX USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; Western Sydney University; University of Texas System;
   University of Texas Southwestern Medical Center; University of Texas
   System; University of Texas Dallas; University of Texas System;
   University of Texas at San Antonio; Baylor College of Medicine
RP Suludere, MA (通讯作者)，Univ Texas Southwestern Med Ctr, Dept Plast Surg, 5323 Harry Hines Blvd F4 124, Dallas, TX 75390 USA.
EM msuludere@gmail.com
RI Tarricone, Arthur/AAN-9955-2021; Najafi, Bijan/AAK-5650-2020
OI Najafi, Bijan/0000-0002-0320-8101; Lavery, Lawrence/0000-0002-7920-9952;
   Suludere, Mehmet Akif/0000-0002-2285-0909
FU American Diabetes Association; Cardinal Health
FX The authors disclosed receipt of the following fi nancial support for
   the research, authorship, and/or publication of this article: This is a
   sub analysis of combined data from two randomized clinical trials. The
   randomized clinical trials were separately funded by American Diabetes
   Association (NCT02308800) and Cardinal Health (NCT02519621). L.A.L is
   the recipient of both grants.
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   Ribet D, 2015, MICROBES INFECT, V17, P173, DOI 10.1016/j.micinf.2015.01.004
   Rippon M, 2023, J WOUND CARE, V32, P359, DOI 10.12968/jowc.2023.32.6.359
   Skrepnek GH, 2017, DIABETES CARE, V40, P936, DOI 10.2337/dc16-2189
   Truong DH, 2022, OPEN FORUM INFECT DI, V9, DOI 10.1093/ofid/ofac407
   Wang GQ, 2023, INT WOUND J, V20, P1739, DOI 10.1111/iwj.13989
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
NR 29
TC 1
Z9 1
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD 2024 NOV 13
PY 2024
DI 10.1177/15347346241292125
EA NOV 2024
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA L8S9U
UT WOS:001353377700001
PM 39533885
OA hybrid
DA 2026-07-24
ER

PT J
AU Su, SQ
   Xiong, DS
   Zeng, ZJ
   Ding, XM
   Kuang, JN
   Lin, YC
   Wu, YW
AF Su, Shunqing
   Xiong, Disheng
   Zeng, Zhijian
   Ding, Xiumei
   Kuang, Jinan
   Lin, Yuechun
   Wu, Yongwei
TI Repair of pressure ulcers in the elderly using autologous microskin
   implantation and negative pressure wound therapy: A retrospective study
SO TECHNOLOGY AND HEALTH CARE
LA English
DT Article
DE Elderly patients; pressure ulcers; skin grafts; vacuum sealing drainage;
   wound repair
ID MANAGEMENT; IMPACT
AB BACKGROUND: Pressure ulcers remain a worldwide problem.
   OBJECTIVE: To introduce an intermittent and feasible wound treatment method for the treatment of pressure ulcers in elderly patients.
   METHODS: This surgical procedure was performed on eight elderly patients suffering from pressure ulcers. Microskin measuring 0.1 x 0.1 centimeters was cut from a small amount of thin skin and then grafted onto the wound surface in conjunction with closed negative pressure therapy.
   RESULTS: Seven patients had their wounds closed after a single surgery, while one patient required two surgeries to close the wound.
   CONCLUSION: Autologous microskin implantation for the treatment of pressure ulcers in the elderly is an effective method to close the wound, which can prevent the elderly from living with wounds in their later years and is a viable treatment option.
C1 [Su, Shunqing; Xiong, Disheng; Ding, Xiumei; Kuang, Jinan; Lin, Yuechun; Wu, Yongwei] Dalang Hosp, Dept Wound Repair, Dongguan, Peoples R China.
   [Zeng, Zhijian] Dalang Hosp, Anorectal Dept, 85 Jinlangzhong Rd, Dongguan 523780, Guangdong, Peoples R China.
RP Zeng, ZJ (通讯作者)，Dalang Hosp, Anorectal Dept, 85 Jinlangzhong Rd, Dongguan 523780, Guangdong, Peoples R China.
EM zhijianzengche@126.com
CR Arai K, 2020, WOUND REPAIR REGEN, V28, P409, DOI 10.1111/wrr.12791
   Chen XL, 2011, BURNS, V37, P973, DOI 10.1016/j.burns.2011.03.022
   Cornish Lynn, 2022, Nurs Older People, DOI [10.7748/nop.2022.e1405, 10.7748/nop.2022.e1405]
   da Silveira JB, 2022, ADV SKIN WOUND CARE, V35, P566, DOI 10.1097/01.ASW.0000855748.02063.99
   Dakhil N, 2019, TECHNOL HEALTH CARE, V27, P669, DOI 10.3233/THC-191637
   Sardo PMG, 2018, J TISSUE VIABILITY, V27, P95, DOI 10.1016/j.jtv.2018.01.002
   Irmak F, 2019, MED B SISLI ETFAL HO, V53, P37, DOI 10.14744/SEMB.2018.70973
   Karahan A, 2018, OSTOMY WOUND MANAG, V64, P32, DOI 10.25270/owm.2018.2.3239
   Kim SS, 2023, TECHNOL HEALTH CARE, V31, P943, DOI 10.3233/THC-220376
   Li YZ, 2015, J Trauma Surg, V17, P9
   Mervis JS, 2019, J AM ACAD DERMATOL, V81, P881, DOI 10.1016/j.jaad.2018.12.069
   Norman G, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012032.pub3
   Rapetti R, 2023, J WOUND CARE, V32, P29, DOI 10.12968/jowc.2023.32.1.29
   Rathi S, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59020410
   Shao WY, 2020, China Rural Health, V12, P20
   Su SQ, 2021, CLIN COSMET INV DERM, V14, P747, DOI 10.2147/CCID.S316694
   Yang KL, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023640
   Zhang MM, 2024, TECHNOL HEALTH CARE, V32, P143, DOI 10.3233/THC-220604
   Zhang M, 2023, INT WOUND J, V20, P1911, DOI 10.1111/iwj.14051
   Zhao HL, 2018, Chin Prac Med, V13, P37
NR 20
TC 1
Z9 1
U1 1
U2 6
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0928-7329
EI 1878-7401
J9 TECHNOL HEALTH CARE
JI Technol. Health Care
PY 2024
VL 32
IS 3
BP 1667
EP 1673
DI 10.3233/THC-230707
PG 7
WC Health Care Sciences & Services; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Engineering
GA RN5A3
UT WOS:001228342100034
PM 37694328
DA 2026-07-24
ER

PT J
AU Hermann, J
   Banasiewicz, T
   Kolodziejczak, B
AF Hermann, Jacek
   Banasiewicz, Tomasz
   Kolodziejczak, Barbara
TI Role of Vacuum-Assisted Closure in the Management of Crohn Anal Fistulas
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE anal fistula; Crohn disease; negative-pressure wound therapy; noncutting
   setons; vacuum-assisted closure; wound healing
ID THERAPY; DISEASE; INFLIXIMAB
AB BACKGROUND: Patients with Crohn disease-related anal fistulas are treated with debridement of fistulous tracts and the placement of noncutting setons (NCSs). However, to reduce the high recurrence rate, there is still a need to develop more effective treatment methods. OBJECTIVE: To compare NCS with vacuum-assisted closure (VAC) treatment. METHODS: Medical records of 47 patients with Crohn anal fistulas were retrospectively evaluated. They were divided into two groups (I, VAC; II, NCS), consisting of 24 and 23 patients, respectively. The fistulas in the former group were applied with VAC, whereas NCSs were placed in the latter group. Fistula healing was evaluated with the Fistula Drainage Assessment classification, Perianal Disease Activity Index, and the van Assche MRI-Based Score. RESULTS: There was a significant difference (P = .006) between the groups; closure of all fistulas at 6 months after treatment was achieved in 18 patients (75%) from group 1, compared with 8 patients (35%) from group 2. Partial response occurred in five patients (21%) from group 1 and in five patients (22%) from group 2. Closure of fistulous tracts was visualized via MRI in nine patients (37.50%) from group 1, more than twice as many patients as from group 2. CONCLUSIONS: Because preliminary results of the study showed a high rate of closure after application of VAC to Crohn anal fistulas, this method might be considered a novel sphincter-saving procedure.
C1 [Hermann, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastroenterol Oncol, Poznan, Poland.
   [Kolodziejczak, Barbara] Poznan Univ Med Sci, Dept Comp Sci & Stat, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Hermann, J (通讯作者)，Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastroenterol Oncol, Poznan, Poland.
RI Kołodziejczak, Barbara/L-6136-2018
OI Kołodziejczak, Barbara/0000-0002-4182-4386
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Banasiewicz T, 2015, TECH COLOPROCTOL, V19, P173, DOI 10.1007/s10151-014-1247-4
   Banasiewicz T, 2015, NEGATIVE PRESSURE WO
   Chidi VN, 2015, EXPERT REV GASTROENT, V9, P797, DOI 10.1586/17474124.2015.1031110
   Gionchetti P, 2017, J CROHNS COLITIS, V11, P135, DOI 10.1093/ecco-jcc/jjw169
   IRVINE EJ, 1995, J CLIN GASTROENTEROL, V20, P27
   MARKS CG, 1981, BRIT J SURG, V68, P525, DOI 10.1002/bjs.1800680802
   Michelassi F, 2000, SURGERY, V128, P597, DOI 10.1067/msy.2000.108779
   Ng SC, 2009, AM J GASTROENTEROL, V104, P2973, DOI 10.1038/ajg.2009.509
   PARKS AG, 1976, BRIT J SURG, V63, P1, DOI 10.1002/bjs.1800630102
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NR 14
TC 4
Z9 5
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2019
VL 32
IS 1
BP 35
EP 40
DI 10.1097/01.ASW.0000547411.16017.58
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA HF7GU
UT WOS:000454408400006
PM 30540570
DA 2026-07-24
ER

PT J
AU Geng, YN
   Ding, N
   Zou, JF
   Zhou, HY
   Zhu, L
AF Geng, Yingnan
   Ding, Neng
   Zou, Jiefeng
   Zhou, Haiyang
   Zhu, Lie
TI Management of a complicated colon-exposed sacrococcygeal wound after
   pelvic exenteration: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE chronic wound; hard-to-heal wound; pelvic exenteration; reconstructive
   surgery; sacrococcygeal area; wound; wound care; wound closure
   techniques; wound dressing; wound healing; wound management
ID VACUUM-ASSISTED CLOSURE; FLAP; RECONSTRUCTION; RESECTION; REPAIR
AB Sacrococcygeal wound management can be challenging, especially when complicated by chronic infection, radiation and exposure of the underlying structures. Vascularised soft-tissue reconstruction is the only option when conservative wound care fails. Previous reports have mainly focused on the treatment of pressure ulcers. This report describes the case of a 54-year-old female patient with a colon-exposed, large sacrococcygeal wound after pelvic exenteration for recurrent rectal cancer. The wound was closed without dead space using two approaches: innovative vacuum sealing drainage (VSD); and gluteus maximus myocutaneous flap repair. Timely debridement, accurate assessment of intervention, appropriate design of composite tissue flap, and conscientious wound care contributed to complete wound healing within two months.
C1 [Geng, Yingnan; Ding, Neng; Zou, Jiefeng; Zhu, Lie] Naval Med Univ, Affiliated Hosp 2, Dept Burns & Plast Surg, Shanghai, Peoples R China.
   [Zhou, Haiyang] Naval Med Univ, Affiliated Hosp 2, Dept Colorectal Surg, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Zhu, L (通讯作者)，Naval Med Univ, Affiliated Hosp 2, Dept Burns & Plast Surg, Shanghai, Peoples R China.; Zhou, HY (通讯作者)，Naval Med Univ, Affiliated Hosp 2, Dept Colorectal Surg, Shanghai, Peoples R China.
EM haiyang1985_1@aliyun.com; zhulie19811@smmu.edu.cn
OI Zhu, Lie/0000-0002-4947-9767
FU Naval Medical University [2022QN073]; University of Shanghai for Science
   and Technology Joint Projects [2020-RZ04]; Innovative Clinical Research
   Program of Shanghai Changzheng Hospital [2020YLCYJ-Y16]
FX This work was supported by the Naval Medical University and the
   University of Shanghai for Science and Technology Joint Projects
   (2020-RZ04) , the Innovative Clinical Research Program of Shanghai
   Changzheng Hospital (2020YLCYJ-Y16) , and the academic project of Naval
   Medical University (2022QN073). The authors have no conflicts of
   interest to declare.
CR Ajimsha MS, 2015, J BODYW MOV THER, V19, P102, DOI 10.1016/j.jbmt.2014.06.001
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NR 15
TC 1
Z9 1
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUL
PY 2024
VL 33
IS 7
BP 515
EP 518
DI 10.12968/jowc.2022.0116
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ZO6G2
UT WOS:001276272300009
PM 38967340
DA 2026-07-24
ER

PT J
AU Adeyemi, A
   Waycaster, C
AF Adeyemi, Ayoade
   Waycaster, Curtis
TI Cost-minimization Analysis of Negative Pressure Wound Therapy in
   Long-term Care Facilities
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE Negative Pressure Wound Therapy; single-use; traditional; cost
   minimization
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; DIABETIC FOOT
   ULCERS; MULTICENTER
AB Objective. This study aims to conduct a cost-minimization analysis comparing wound treatment costs between single-use negative pressure wound therapy (sNPWT) and traditional negative pressure wound therapy (tNPWT).
   Materials and Methods. Assuming comparable outcomes, cost data obtained from the ECRI Institute were compared between the 2 NPWT options using data extracted from an electronic wound management program between August 2010 and March 2016. Results. Use of sNPWT versus tNPWT resulted in daily and total treatment duration cost savings of $55 and $1586, respectively. Conclusions. Long-term care facilities can potentially accrue significant cost savings by using sNPWT instead of tNPWT on a majority of eligible wounds.
   As of 2014, $28.1 billion was a conservative estimate of health care costs for the 8.2 million Medicare beneficiaries with >= 1 type of wound or wound-related infection in the United States. 1 Evidence supporting superior clinical outcomes of negative pressure wound therapy (NPWT) versus standard of care include promotion of granulation tissue formation, reduced time to wound closure, and increased proportion of wounds that achieve closure for diabetic foot ulcers, venous leg ulcers, and full-thickness wounds. 2-5Although NPWT can lower costs by reducing treatment duration and health care resource use, 6,7 the cost of prolonged wound care can be significant.
   Traditional NPWT (tNPWT) systems use large, reusable electrical pumps to deliver negative pressure while single-use NPWT (sNPWT; PICO; Smith & Nephew, Fort Worth, TX) are portable systems designed for single-use and assumed to have comparable clinical outcomes as tNWPT, with the potential to reduce wound care costs compared with tNPWT. 8-11 To examine this possibility, the authors identified the proportion of wounds on tNPWT amenable to sNPWT based on certain wound characteristics and estimated through a cost-minimization analysis whether the use of sNPWT compared with tNPWT systems could result in cost savings for long-term health care facilities (LCFs).
C1 [Adeyemi, Ayoade; Waycaster, Curtis] Smith & Nephew Inc, 150 Minuteman Rd, Andover, MA 01810 USA.
C3 Smith & Nephew
RP Adeyemi, A (通讯作者)，Smith & Nephew Inc, 150 Minuteman Rd, Andover, MA 01810 USA.
EM Ayoade.Adeyemi@smith-nephew.com
FU Smith Nephew, Inc.
FX This study was funded by Smith & Nephew, Inc. Both authors are paid
   employees of Smith & Nephew. Joann Hettasch, PhD (Fishawack
   Communications, Inc, Conshohocken, PA), provided medical writing
   support.
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   Gabriel A, 2013, INT WOUND J, V10, P418, DOI 10.1111/j.1742-481X.2012.00999.x
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NR 15
TC 5
Z9 5
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2018
VL 30
IS 2
BP E13
EP +
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GB3XM
UT WOS:000428993700002
PM 29481332
DA 2026-07-24
ER

PT J
AU Driver, VR
   Eckert, KA
   Carter, MJ
   French, MA
AF Driver, Vickie R.
   Eckert, Kristen A.
   Carter, Marissa J.
   French, Michael A.
TI Cost-effectiveness of negative pressure wound therapy in patients with
   many comorbidities and severe wounds of various etiology
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ELECTRIC-STIMULATION THERAPY; DIABETIC FOOT
   ULCERS; CARE; UTILITY
AB This study analyzed a cross-section of patients with severe chronic wounds and multiple comorbidities at an outpatient wound clinic, with regard to the cost-effectiveness and cost-benefit of negative pressure wound therapy (intervention) vs. no negative pressure wound therapy (control) at 1 and 2 years. Medicare reimbursement charges for wound care were used to calculate costs. Amputation charges were assessed using diagnosis-related groups. Cost-benefit analysis was based on ulcer-free months and cost-effectiveness on quality-adjusted life-years. Undiscounted costs, benefits, quality-adjusted life-years, undiscounted and discounted incremental net health benefits, and incremental cost-effectiveness ratios were calculated for unmatched and matched cohorts. There were 150 subjects in the intervention group and 154 controls before matching and 103 subjects in each of the matched cohorts. Time to heal for the intervention cohort was significantly shorter compared to the controls (270 vs. 635 days, p=1.0 x 10(-7), matched cohorts). The intervention cohort had higher benefits and quality-adjusted life-year gains compared to the control cohort at years 1 and 2; by year 2, the gains were 68-73% higher. In the unmatched cohorts, the incremental net health benefit was $9,933 per ulcer-free month at year 2 for the intervention; the incremental cost-effectiveness ratio was -825,271 per quality-adjusted life-year gained (undiscounted costs and benefits). For the matched cohorts, the incremental net health benefits was only $1,371 per ulcer-free month for the intervention, but the incremental cost-effectiveness ratio was $366,683 per quality-adjusted life-year gained for year 2 (discounted costs and benefits). In a patient population with severe chronic wounds and serious comorbidities, negative pressure wound therapy resulted in faster healing wounds and was more cost-effective with greater cost-benefits than not using negative pressure wound therapy. Regarding overall cost-effectiveness, the intervention was still expensive, but that is the reality amidst limited treatment options for such serious cases of chronic wounds.
C1 [Driver, Vickie R.] Brown Univ, Sch Med, Providence, RI 02912 USA.
   [Driver, Vickie R.] Rhode Isl Hosp, HBO & Wound Healing Ctr, Providence, RI USA.
   [Driver, Vickie R.] Novartis Inst Biomed Res, New Indicat Discovery Unit, Cambridge, MA USA.
   [Eckert, Kristen A.; Carter, Marissa J.] Strateg Solut Inc, Cody, WY USA.
   [French, Michael A.] VA Providence Med Ctr, Providence, RI USA.
C3 Brown University; Lifespan Health Rhode Island; Rhode Island Hospital;
   Novartis; Novartis USA
RP Driver, VR (通讯作者)，830 Chalkstone Ave, Providence, RI 02908 USA.
EM drvdriver@aol.com
FU KCI, An Acelity Company, San Antonio, TX
FX KCI, An Acelity Company, San Antonio, TX.
CR [Anonymous], 2014, CURR PROC TERM CPT S
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NR 26
TC 18
Z9 21
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV-DEC
PY 2016
VL 24
IS 6
BP 1041
EP 1058
DI 10.1111/wrr.12483
PG 18
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA EI9JV
UT WOS:000392825000135
PM 27669667
DA 2026-07-24
ER

PT J
AU Xu, MZ
   Wang, YC
   Ma, XY
   Liu, YJ
   Xue, CY
   Dai, HY
AF Xu, Mingze
   Wang, Yuchong
   Ma, Xinyi
   Liu, Yanjun
   Xue, Chunyu
   Dai, Haiying
TI 被撤回的出版物: Simplified and modified Limberg flap plus vacuum-assisted
   closure for treatment of sacrococcygeal pilonidal sinus disease
   (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE complications; Limberg flap; negative pressure wound therapy; pilonidal
   sinus; vacuum-assisted closure
ID TRANSPOSITION FLAP
AB Background: Pilonidal sinus disease (PSD), a chronic inflammatory disease, affects the sacrococcygeal soft tissue, especially in young adults. The ideal treatment for PSD remains divergence. This study evaluated the application of a simplified modified Limberg flap combined with vacuum-assisted closure for treating PSD.
   Methods: This prospective study was conducted from 1 June 2017 to 31 March 2022 in Changhai Hospital, Naval Military Medical University, Shanghai, China. The study included 88 male patients (91.7%) and 8 female patients (8.3%). The 96 patients ranged in age from 15 to 34 years (mean +/- SD, 23 +/- 4.4). Under general anaesthesia, all patients underwent simplified modified Limberg flap reconstruction with vacuum-assisted closure. The patient's weight, surgical time, extubation time, hospital stay, time to return to normal life or work, wound infection, wound dehiscence and recurrence rate were recorded. The visual analogue scale (VAS) score and the Vancouver scar score were used to score patients' pain and scars in the surgical area.
   Results: The volume of resected diseased tissue was 13.5-120 (mean +/- SD, 34.993 +/- 24.406) cm2. The average surgical time during the treatment period was 97.68 +/- 18.72 min, and the average extubation time was (6.36 +/- 1.55) days, the mean hospital stay was 19.4 days; no patients were lost to follow-up. None of the patients experienced post-operative recurrence, wound infection, seroma or hematoma. Six patients (6.3%) experienced wound dehiscence at the flap tip around the natal cleft. The mean time to the resumption of daily activities was 26.3 days. The average VAS pain score was (6.00 +/- 1.53) points, and the average Vancouver scar score was (5.96 +/- 1.51) points, 12 patients (12.5%) were dissatisfied with their aesthetic results, and the average beauty satisfaction score is (6.64 +/- 1.28) points.
   Conclusions: Simplified modified Limberg flap reconstruction with vacuum-assisted closure surgery is an effective and innovative method for the treatment of PSD, with a low recurrence rate and rapid recovery.
C1 [Xu, Mingze; Wang, Yuchong; Ma, Xinyi; Liu, Yanjun; Xue, Chunyu; Dai, Haiying] Naval Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Dai, Haiying] Naval Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Dai, HY (通讯作者)，Naval Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM hiayd68@163.com
FU National Natural Science Foundation of China [81871578]
FX National Natural Science Foundation of China, Grant/Award Number:
   81871578
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NR 33
TC 3
Z9 5
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN
PY 2024
VL 21
IS 1
DI 10.1111/iwj.14353
EA SEP 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IT6N1
UT WOS:001065100200001
PM 37691134
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wilkes, R
   Zhao, Y
   Kieswetter, K
   Haridas, B
AF Wilkes, R.
   Zhao, Y.
   Kieswetter, K.
   Haridas, B.
TI Effects of Dressing Type on 3D Tissue Microdeformations During Negative
   Pressure Wound Therapy: A Computational Study
SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
LA English
DT Article
DE biology computing; biomechanics; cellular biophysics; computerised
   tomography; deformation; finite element analysis; patient treatment;
   polymer foams; skin; wounds
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; ENDOTHELIAL-CELLS;
   RANDOMIZED-TRIAL; GROWTH-CONTROL; BLOOD-FLOW; ANGIOGENESIS; MATRIX;
   PROLIFERATION; TENSION
AB Vacuum-assisted closure (R) (VAC (R)) therapy, also referred to as vacuum-assisted closure (R) negative pressure wound therapy (VAC (R) NPWT), delivered to various dermal wounds is believed to influence the formation of granulation tissue via the mechanism of microdeformational signals. In recent years, numerous experimental investigations have been initiated to study the cause-effect relationships between the mechanical signals and the transduction pathways that result in improved granulation response. To accurately quantify the tissue microdeformations during therapy, a new three-dimensional finite element model has been developed and is described in this paper. This model is used to study the effect of dressing type and subatmospheric pressure level on the variations in the microdeformational strain fields in a model dermal wound bed. Three-dimensional geometric models representing typical control volumes of NPWT dressings were generated using micro-CT scanning of VAC (R) GranuFoam (R), a reticulated open-cell polyurethane foam (ROCF), and a gauze dressing (constructed from USP Class VII gauze). Using a nonlinear hyperfoam constitutive model for the wound bed, simulated tissue microdeformations were generated using the foam and gauze dressing models at equivalent negative pressures. The model results showed that foam produces significantly greater strain than gauze in the tissue model at all pressures and in all metrics (p < 0.0001 for all but epsilon(vol) at -50 mm Hg and -100 mm Hg where p < 0.05). Specifically, it was demonstrated in this current work that the ROCF dressing produces higher levels of tissue microdeformation than gauze at all levels of subatmospheric pressure. This observation is consistent across all of the strain invariants assessed, i.e., epsilon(vol), epsilon(dist), the minimum and maximum principal strains, and the maximum shear strain. The distribution of the microdeformations and strain appears as a repeating mosaic beneath the foam dressing, whereas the gauze dressings appear to produce an irregular distribution of strains in the wound surface. Strain predictions from the developed computational model results agree well with those predicted from prior two-dimensional experimental and computational studies of foam-based NPWT (Saxena, V., , 2004, "Vacuum-assisted closure: Microdeformations of Wounds and Cell Proliferation," Plast. Reconstr. Surg., 114(5), pp. 1086-1096). In conjunction with experimental in vitro and in vivo studies, the developed model can now be extended into more detailed investigations into the mechanobiological underpinnings of VAC (R) NPWT and can help to further develop and optimize this treatment modality for the treatment of challenging patient wounds.
C1 [Wilkes, R.; Zhao, Y.; Kieswetter, K.] Kinet Concepts Inc, San Antonio, TX 78249 USA.
   [Haridas, B.] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45221 USA.
   [Haridas, B.] Device & Implant Innovat LLC, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Wilkes, R (通讯作者)，Kinet Concepts Inc, San Antonio, TX 78249 USA.
EM rob.wilkes@kci1.com
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NR 48
TC 45
Z9 59
U1 0
U2 16
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0148-0731
EI 1528-8951
J9 J BIOMECH ENG-T ASME
JI J. Biomech. Eng.-Trans. ASME
PD MAR
PY 2009
VL 131
IS 3
AR 031012
DI 10.1115/1.2947358
PG 12
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA 432MG
UT WOS:000265137800012
PM 19154071
DA 2026-07-24
ER

PT J
AU Osterhoff, G
   Zwolak, P
   Krüger, C
   Wilzeck, V
   Simmen, HP
   Jukema, GN
AF Osterhoff, Georg
   Zwolak, Pawel
   Krueger, Carmen
   Wilzeck, Verena
   Simmen, Hans-Peter
   Jukema, Gerrolt N.
TI Risk factors for prolonged treatment and hospital readmission in 280
   cases of negative-pressure wound therapy
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; Vacuum-assisted closure; Open
   fractures; Risk factors; Wound healing
ID VACUUM-ASSISTED CLOSURE; MECHANISMS
AB Background: There is evidence of certain beneficial effects and increasing understanding of the mechanisms of action of negative-pressure wound therapy (NPWT). However, it is known that prolonged duration of NPWT is associated with increased bacterial growth and efforts should be made to decrease the duration of NPWT. It was the aim of this study to evaluate potential risk factors for the duration, from first application of NPWT to secondary wound closure and to identify factors that increase the rate of hospital readmission.
   Methods: In a retrospective cohort study, 261 patients (46 +/- 19 years, 70 female) who underwent 280 treatments with NPWT were analysed. Patient-specific and demographic characteristics and the presence of several risk factors were documented. The duration of treatment from first application of NPWT to secondary wound closure, the number of interventions, the duration of hospital stay and the incidence of readmissions due to complications of the wound treated by NPWT were recorded and a risk factor analysis was performed.
   Results: The median number of NPWT procedures was 2.0 +/- 2.0, the duration of NPWT was 6.0 +/- 14.7 days and the length of hospital stay was 16.0 +/- 27.9 days. Presence of an open fracture (p = .002) and increased age (p = .004) were identified as independent risk factors for a prolonged duration of NPWT. Patients who smoked (p = .001) or patients with alcohol/drug abuse (p = .015) were more likely to return to hospital (smoking: 18 out of 58 cases; alcohol/drug abuse: 7 out of 19 cases). No such association was seen for diabetes (p = .702), peripheral vascular disease (PVD) (p = .052), immunosuppressive medication (p = .187), immunodeficiency (p = .404), trauma (p = .358), infection (p = .298) and open fracture (p = .061).
   Conclusions: Patient age and presence of an open fracture are independent predictors of a prolonged duration from first application of NPWT to secondary wound closure. These results should be taken into account for the calculation of average costs and anticipated hospital stay associated with this therapy. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Osterhoff, Georg; Zwolak, Pawel; Krueger, Carmen; Wilzeck, Verena; Simmen, Hans-Peter; Jukema, Gerrolt N.] Univ Zurich, Div Trauma Surg, CH-8091 Zurich, Switzerland.
C3 University of Zurich
RP Osterhoff, G (通讯作者)，Univ Zurich Hosp, Div Trauma Surg, Dept Surg, Raemistr 100, CH-8091 Zurich, Switzerland.
EM georg.osterhoff@usz.ch
RI ; Osterhoff, Georg/IXW-9149-2023
OI Simmen, Hans-Peter/0000-0002-5201-4549; Osterhoff,
   Georg/0000-0001-5051-0998
CR [Anonymous], GER MED SCI
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NR 20
TC 18
Z9 18
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2014
VL 67
IS 5
BP 629
EP 633
DI 10.1016/j.bjps.2014.01.010
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AE2OE
UT WOS:000333811800016
PM 24507965
DA 2026-07-24
ER

PT J
AU Shadid, O
   Novo, J
   Saini, R
   Seth, I
   Terrill, PJ
   Rozen, WM
AF Shadid, Omar
   Novo, Jennifer
   Saini, Raj
   Seth, Ishith
   Terrill, Patricia J.
   Rozen, Warren M.
TI Incidence of surgical site infections at skin graft recipient sites with
   negative pressure wound therapy: A meta-analysis
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy (NPWT); Surgical site infections (SSIs);
   Graft infections; Wound healing; Postoperative infections;
   Vacuum-assisted closure (VAC)
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL DRESSING METHODS; SOFT-TISSUE
   RECONSTRUCTION; FLAP DONOR SITE; FULL-THICKNESS; MANAGEMENT; EFFICACY;
   COST; DRAINAGE; BOLSTER
AB Background Skin graft failure remains a common and challenging source of postoperative morbidity, often driven by surgical site infections. Negative pressure wound therapy (NPWT), a technique that applies controlled suction to the wound surface, has been proposed to improve graft outcomes. This systematic review assessed the efficacy of NPWT in reducing SSIs following grafting procedures. Methods A comprehensive search of the PubMed, MEDLINE, Embase, Cochrane Library, and Web of Science was performed in March 2025. Twenty-eight studies involving 2366 patients were included. The primary outcome was SSI incidence. Subgroup analyses examined NPWT type (traditional vs single-use), wound etiology and graft location. Results NPWT significantly reduced SSI rates compared to conventional dressings (5.9% vs 14.3%). Meta-analysis using a random-effects model showed a 59% reduction in the odds of infection (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.25-0.67; p < 0.001; I-2 = 41.6%). Traditional NPWT was effective (OR = 0.38; 95% CI, 0.23-0.63), while single-use NPWT was not (OR = 1.32; 95% CI, 0.19-9.27). NPWT showed significant benefit in burn wounds (OR = 0.09; 95% CI, 0.01-0.82; based on one study) and non-significant trend toward benefit in trauma wounds (OR = 0.31; 95% CI, 0.10-1.01). Lower-limb grafts demonstrated a numerical reduction in infection rates (OR = 0.55), though this was not significant. Mean graft take was approximately 7% higher in the NPWT group; however, these findings are only descriptive and were not subjected to meta-analysis. Conclusions NPWT significantly lowers SSI risk in skin grafts, particularly with traditional systems. Subgroup trends in trauma and lower-limb wounds are promising but not statistically significant and should be considered as hypothesis-generating. Single-use NPWT requires further evaluation. These findings support NPWT's broader integration into high-risk graft protocols, with device selection tailored to wound complexity and care setting.
C1 [Shadid, Omar] Univ Melbourne, Fac Med & Surg, Melbourne, Vic 3051, Australia.
   [Novo, Jennifer] Notre Dame Univ, Fac Med & Surg, Sydney, NSW 2008, Australia.
   [Saini, Raj] Simon Fraser Univ, Fac Med & Surg, Burnaby, BC V5A 1S6, Canada.
   [Seth, Ishith; Terrill, Patricia J.; Rozen, Warren M.] Monash Univ, Alfred Ctr, Peninsula Clin Sch, 99 Commercial Rd, Melbourne, Vic 3004, Australia.
   [Seth, Ishith; Terrill, Patricia J.; Rozen, Warren M.] Peninsula Hlth, Dept Plast & Reconstruct Surg, Melbourne, Vic 3199, Australia.
C3 University of Melbourne; The University of Notre Dame Australia; Simon
   Fraser University; Monash University; Peninsula Health
RP Shadid, O (通讯作者)，Univ Melbourne, Fac Med & Surg, Melbourne, Vic 3051, Australia.
EM omarshadid4@gmail.com
RI Terrill, Patricia/ABD-5014-2021; Seth, Ishith/IXX-0725-2023; Rozen,
   Warren/AAE-6296-2022
OI Terrill, Patricia/0000-0002-4971-2776; Seth, Ishith/0000-0001-5444-8925;
   Shadid, Omar/0009-0005-3471-8656; Saini, Saravraj/0009-0008-2480-7825; ,
   Jennifer/0009-0005-3919-904X; Kustos, Milan/0009-0009-1612-5274
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NR 73
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2025
VL 110
BP 306
EP 321
DI 10.1016/j.bjps.2025.08.038
EA OCT 2025
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9EP9F
UT WOS:001604518600005
PM 40967918
DA 2026-07-24
ER

PT J
AU Baharestani, M
   Amjad, I
   Bookout, K
   Fleck, T
   Gabriel, A
   Kaufman, D
   McCord, SS
   Moores, DC
   Olutoye, OO
   Salazar, JD
   Song, DH
   Teich, S
   Gupta, S
AF Baharestani, Mona
   Amjad, Ibrahim
   Bookout, Kim
   Fleck, Tatjana
   Gabriel, Allen
   Kaufman, David
   McCord, Shannon Stone
   Moores, Donald C.
   Olutoye, Oluyinka O.
   Salazar, Jorge D.
   Song, David H.
   Teich, Steven
   Gupta, Subhas
TI VAC® Therapy in the management of paediatric wounds: clinical review and
   experience
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; NPWT; VAC Therapy; Vacuum-assisted
   closure; Paediatric wound care; Abdominal compartment syndrome;
   astroschisis
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; SECURING
   SKIN-GRAFTS; OPEN CELL FOAM; SPINAL-FUSION; SUBATMOSPHERIC PRESSURE;
   ENTEROCUTANEOUS FISTULA; POSTOPERATIVE INFECTIONS; TEMPORARY TREATMENT;
   PILONIDAL DISEASE
AB Usage of negative pressure wound therapy (NPWT) in the management of acute and chronic wounds has grown exponentially in the past decade. Hundreds of studies have been published regarding outcomes and methods of therapy used for adult wounds. This treatment is increasingly being used to manage difficult-to-treat paediatric wounds arising from congenital defects, trauma, infection, tumour, burns, pressure ulceration and postsurgical complications in children, although relatively few studies have been aimed at this population. Given the anatomical and physiological differences between adults and children, a multidisciplinary expert advisory panel was convened to determine appropriate use of NPWT with reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum Assisted Closure (R) (V.A.C.(R) Therapy, KCI Licensing, Inc., San Antonio, TX) for the treatment of paediatric wounds.
   The primary objectives of the expert advisory panel were to exchange state-of-practice information on paediatric wound care, review the published data regarding the use of NPWT/ROCF in paediatric wounds, evaluate the strength of the existing data and establish guidelines on best practices with NPWT/ROCF for the paediatric population. The proposed paediatrics-specific clinical practice guidelines are meant to provide practitioners an evidence base from which decisions could be made regarding the safe and efficacious selection of pressure settings, foam type, dressing change frequency and use of interposing contact layer selections. The guidelines reflect the state of knowledge on effective and appropriate wound care at the time of publication. They are the result of consensus reached by expert advisory panel members based on their individual clinical and published experiences related to the use of NPWT/ROCF in treating paediatric wounds. Best practices are described herein for novice and advanced users of NPWT/ROCF. Recommendations by the expert panel may not be appropriate for use in all circumstances. Decisions to adopt any particular recommendation must be made by the collaborating medical team, including the surgeon and wound care specialist based on available resources, individual patient circumstances and experience with the V.A.C.(R) Therapy System.
C1 [Baharestani, Mona] E Tennessee State Univ, Ctr Nursing Res, Johnson City, TN 37614 USA.
   [Bookout, Kim] Childrens Med Ctr, Dallas, TX 75235 USA.
   [Fleck, Tatjana] Med Univ Vienna, Dept Cardiothorac Surg, Vienna, Austria.
   [Gabriel, Allen; Gupta, Subhas] Loma Linda Univ, Sch Med, Dept Plast Surg, Loma Linda, CA USA.
   [Kaufman, David] Univ Virginia, Sch Med, Dept Pediat, Charlottesville, VA 22908 USA.
   [Kaufman, David] Univ Virginia, Sch Med, Div Neonatol, Charlottesville, VA 22908 USA.
   [McCord, Shannon Stone] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Moores, Donald C.] Loma Linda Univ, Childrens Hosp, Div Pediat Surg, Loma Linda, CA 92350 USA.
   [Olutoye, Oluyinka O.] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA.
   [Salazar, Jorge D.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
   [Song, David H.] Univ Chicago Hosp, Pritzker Sch Med, Sect Plast Surg, Chicago, IL 60637 USA.
   [Teich, Steven] Childrens Hosp Columbus, Dept Surg, Columbus, OH USA.
C3 East Tennessee State University; Medical University of Vienna; Loma
   Linda University; University of Virginia; University of Virginia; Baylor
   College of Medicine; Baylor College Medical Hospital; Children's
   Hospital Los Angeles; Loma Linda University; Baylor College of Medicine;
   University of Texas System; University of Texas at San Antonio;
   University of Illinois System; University of Chicago; University of
   Chicago Medical Center; University System of Ohio; Ohio State
   University; Nationwide Childrens Hospital
RP Baharestani, M (通讯作者)，E Tennessee State Univ, Ctr Nursing Res, Roy Nicks Hall,Off 1-112, Johnson City, TN 37614 USA.
EM baharest@etsu.edu
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922
FU AACN VAC; KCI; Hutchinson Technologies, Inc; Kinetic Concepts, Inc.
FX S.M. is the primary investigator on a AACN VAC research grant.
   Additional funding has been provided by KCI. O.O. has received grant
   funding from the following companies for the named research projects:
   Hutchinson Technologies, Inc: "Assessing gut oxygenation in premature
   infants using near infrared spectroscopy" and Kinetic Concepts, Inc.
   "Negative Pressure Wound Therapy".
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NR 153
TC 59
Z9 87
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2009
VL 6
SU 1
BP 1
EP 26
DI 10.1111/j.1742-481X.2009.00607.x
PG 26
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16CB
UT WOS:000207846600001
PM 19614789
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Davis, K
   Bills, J
   Barker, J
   Kim, P
   Lavery, L
AF Davis, Kathryn
   Bills, Jessica
   Barker, Jenny
   Kim, Paul
   Lavery, Lawrence
TI Simultaneous irrigation and negative pressure wound therapy enhances
   wound healing and reduces wound bioburden in a porcine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; POLYHEXANIDE;
   INSTILLATION
AB Infected foot wounds are one of the most common reasons for hospitalization and amputation among persons with diabetes. The objective of the study was to investigate a new wound therapy system that employs negative pressure wound therapy (NPWT) with simultaneous irrigation therapy. For this study, we used a porcine model with full-thickness excisional wounds, inoculated with Pseudomonas aeruginosa. Wounds were treated for 21 days of therapy with either NPWT, NPWT with simultaneous irrigation therapy using normal saline or polyhexanide biguanide (PHMB) at low or high flow rates, or control. Data show that NPWT with either irrigation condition improved wound healing rates over control-treated wounds, yet did not differ from NPWT alone. NPWT improved bioburden over control-treated wounds. NPWT with simultaneous irrigation further reduced bioburden over control and NPWT-treated wounds; however, flow rate did not affect these outcomes. Together, these data show that NPWT with simultaneous irrigation therapy with either normal saline or PHMB has a positive effect on bioburden in a porcine model, which may translate clinically to improved wound healing outcomes.
C1 [Davis, Kathryn; Bills, Jessica; Barker, Jenny; Kim, Paul; Lavery, Lawrence] Univ Texas SW Med Ctr Dallas, Dept Plast Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center
RP Davis, K (通讯作者)，Univ Texas SW Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd,F4-310A, Dallas, TX 75390 USA.
EM kathryn.davis@utsouthwestern.edu
RI Barker, Jenny/KYR-0129-2024
OI Barker, Jenny/0000-0002-1517-5124; Lavery, Lawrence/0000-0002-7920-9952;
   , Paul/0000-0002-6186-6890
FU Innovative Therapies, Inc.
FX Source of Funding: This research was funded through an educational grant
   from Innovative Therapies, Inc.
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NR 35
TC 37
Z9 40
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD NOV
PY 2013
VL 21
IS 6
BP 869
EP 875
DI 10.1111/wrr.12104
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 243OU
UT WOS:000326327100158
PM 24134060
OA Bronze
DA 2026-07-24
ER

PT J
AU Peinemann, F
   Sauerland, S
AF Peinemann, Frank
   Sauerland, Stefan
TI Negative-Pressure Wound Therapy Systematic Review of Randomized
   Controlled Trials
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; MANAGEMENT; ULCERS
AB Background: In negative-pressure wound therapy (NPWT), a wound is covered with an airtight dressing, and negative pressure is applied. This is thought to promote healing. We evaluated NPWT with an updated, systematic review of the literature.
   Methods: We systematically searched the PubMed and Cochrane Library databases for randomized, controlled trials (RCTs) of NPWT for the treatment of acute or chronic wounds. The primary outcome was complete wound closure.
   Results: We found reports of 9 RCTs in addition to the 12 covered by earlier IQWiG reviews of this topic. Five of the 9 new trials involved NPWT systems that are not on the market. The frequency of complete wound closure is stated in only 5 of the 9 new reports; a statistically significant effect in favor of NPWT was found in only two trials. The results of 8 of the 9 new trials are hard to interpret, both because of apparent bias and because diverse types of wounds were treated.
   Conclusion: Although there may be a positive effect of NPWT, we did not find clear evidence that wounds heal any better or worse with NPWT than with conventional treatment. Good RCTs are still needed to evaluate NPWT.
C1 [Peinemann, Frank; Sauerland, Stefan] IQWIG, D-51105 Cologne, Germany.
RP Peinemann, F (通讯作者)，IQWIG, Dillenburger Str 27, D-51105 Cologne, Germany.
EM frank.peinemann@iqwig.de
RI ; /H-2800-2019
OI Sauerland, Stefan/0000-0003-1048-796X; 
FU Institute for Quality and Efficiency in Health Care (Institut fur
   Qualitat und Wirtschaftlichkeit im Gesundheitswesen, IQWiG)
FX This article was sponsored by the Institute for Quality and Efficiency
   in Health Care (Institut fur Qualitat und Wirtschaftlichkeit im
   Gesundheitswesen, IQWiG).
CR [Anonymous], N0403 IQWIG
   [Anonymous], SER COMPL ASS NEG PR
   [Anonymous], DRAFT GUID IND CHRON
   [Anonymous], N0602 IQWIG
   [Anonymous], STUD VAK BEL CHRON W
   [Anonymous], VERG STUD VAK RAP
   [Anonymous], NEG PRESS WOUND THER
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NR 35
TC 94
Z9 110
U1 0
U2 15
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD JUN 3
PY 2011
VL 108
IS 22
BP 381
EP U15
DI 10.3238/arztebl.2011.0381
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 787OR
UT WOS:000292387100001
PM 21712971
DA 2026-07-24
ER

PT J
AU Pachowsky, M
   Gusinde, J
   Klein, A
   Lehrl, S
   Schulz-Drost, S
   Schlechtweg, P
   Pauser, J
   Gelse, K
   Brem, MH
AF Pachowsky, Milena
   Gusinde, Johannes
   Klein, Andrea
   Lehrl, Siegfried
   Schulz-Drost, Stefan
   Schlechtweg, Philipp
   Pauser, Johannes
   Gelse, Kolja
   Brem, Matthias H.
TI Negative pressure wound therapy to prevent seromas and treat surgical
   incisions after total hip arthroplasty
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; OPEN FRACTURES; TRAUMA; MANAGEMENT; DEFECT;
   BONE
AB The purpose of this study was to evaluate the use of negative pressure wound therapy (NPWT) to improve wound healing after total hip arthroplasty (THA) and its influence on the development of postoperative seromas in the wound area.
   The study is a prospective randomised evaluation of NPWT in patients with large surgical wounds after THA, randomising patients to either a standard dressing (group A) or a NPWT (group B) over the wound area. The wound area was examined with ultrasound to measure the postoperative seromas in both groups on the fifth and tenth postoperative days.
   There were 19 patients randomised in this study. Ten days after surgery, group A (ten patients, 70.5 +/- 11.01 years of age) developed seromas with an average size of 5.08 ml and group B (nine patients, 66.22 +/- 17.83 years of age) 1.97 ml. The difference was significant (p = 0.021).
   NPWT has been used on many different types of traumatic and non traumatic wounds. This prospective, randomised study has demonstrated decreased development of postoperative seromas in the wound and improved wound healing.
C1 [Pachowsky, Milena; Gusinde, Johannes; Klein, Andrea; Schulz-Drost, Stefan; Gelse, Kolja; Brem, Matthias H.] Univ Erlangen Nurnberg, Dept Surg, Div Trauma Surg & Orthopaed Surg, D-91054 Erlangen, Germany.
   [Lehrl, Siegfried] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany.
   [Schlechtweg, Philipp] Univ Erlangen Nurnberg, Dept Radiol, D-91054 Erlangen, Germany.
   [Pauser, Johannes] Univ Erlangen Nurnberg, Dept Orthopaed Rhumatol, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Brem, MH (通讯作者)，Univ Erlangen Nurnberg, Dept Surg, Div Trauma Surg & Orthopaed Surg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM brem@bwh.harvard.edu
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NR 20
TC 162
Z9 193
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2695
J9 INT ORTHOP
JI Int. Orthop.
PD APR
PY 2012
VL 36
IS 4
BP 719
EP 722
DI 10.1007/s00264-011-1321-8
PG 4
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 917JP
UT WOS:000302171000005
PM 21761149
OA Bronze
DA 2026-07-24
ER

PT J
AU Zhang, LP
   Weng, TT
   Wu, P
   Li, Q
   Han, CM
   Wang, XG
AF Zhang, Liping
   Weng, Tingting
   Wu, Pan
   Li, Qiong
   Han, Chunmao
   Wang, Xingang
TI The Combined Use of Negative-Pressure Wound Therapy and Dermal
   Substitutes for Tissue Repair and Regeneration
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; CLINICAL EFFECTIVENESS; ENHANCED
   ANGIOGENESIS; IN-VIVO; SKIN; RECONSTRUCTION; SCAFFOLDS; DEFECTS; BURNS
AB In clinical practice, skin defects occur frequently due to various kinds of acute and chronic diseases. The standard treatment for these wounds is autografting, which usually results in complications such as scar formation and new wounds at donor sites. The advent of dermal substitutes has provided a novel method for wound repair, and rapid angiogenesis of the dermal substitutes is crucial for the graft to take. At present, many strategies have been developed to improve the process of vascularisation, some of which have shown promising potentials, but they could be very far from clinical applications. Most recently, negative-pressure wound therapy (NPWT) has been used extensively in clinical practice for wound care and management. It has been reported that NPWT reduces the time required for vascular ingrowth into the dermal substitute and improves graft take, indicating great potentials for wound repair. This article presents a comprehensive overview of the combined use of NPWT and dermal substitutes for tissue repair and regeneration. Relative concerns and prospects are also discussed.
C1 [Zhang, Liping; Weng, Tingting; Wu, Pan; Li, Qiong; Han, Chunmao; Wang, Xingang] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou 310009, Peoples R China.
   [Weng, Tingting] Zhejiang Univ, Coll Med, Hangzhou 310000, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Wang, XG (通讯作者)，Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Burns & Wound Care Ctr, Hangzhou 310009, Peoples R China.
EM lpzhang_246@163.com; 1347543482@qq.com; wupan_lhl@zju.edu.cn;
   liq2007.best@163.com; zrssk@zju.edu.cn; wangxingang8157@zju.edu.cn
FU National Natural Science Foundation of China [817720691, 8140159];
   National Key Research and Development Program of China [2016YFC1100803];
   Zhejiang Provincial Medical and Health Discipline Platform Project
   [2018RC035]
FX This work was financially supported by the National Natural Science
   Foundation of China (817720691 and 8140159), the National Key Research
   and Development Program of China (2016YFC1100803), and Zhejiang
   Provincial Medical and Health Discipline Platform Project (2018RC035).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 62
TC 27
Z9 28
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD DEC 4
PY 2020
VL 2020
AR 8824737
DI 10.1155/2020/8824737
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA PG7CJ
UT WOS:000599889000003
PM 33344649
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Cunningham, T
   Marks, M
AF Cunningham, Teresa
   Marks, Malcolm
TI Vacuum-Assisted Closure Device and Skin Substitutes for Complex Mohs
   Defects
SO DERMATOLOGIC SURGERY
LA English
DT Article
ID ARTIFICIAL SKIN; PRESSURE; MANAGEMENT; DRESSINGS; THERAPY; INTEGRA;
   GRAFTS; TRIAL
AB BACKGROUND Soft tissue defects created by excision of dermatologic malignancies may present a significant challenge to the reconstructive surgeon, particularly when tendon, bone, cartilage, or other vital structures are exposed. Although there are several reliable options for regional or free tissue transfer, many patients with skin cancers are poor surgical candidates. Recent literature has described the use of an acellular dermal regeneration template (ADRT) (Integra LifeSciences Corp, Plainsboro, NJ) with split-thickness skin grafting (STSG) as an alternative to the previously mentioned surgical options.
   OBJECTIVE To use ADRT with negative-pressure wound therapy (NPWT) and STSG to reconstruct complex Mohs defects of the scalp and feet.
   MATERIALS AND METHODS Two patients underwent wide local excision of squamous cell carcinomas of the skin. ADRT and a NPWT device were applied. The patients were then skin grafted 7 to 10 days later.
   RESULTS Both patients had take of their skin grafts and completely healed their wounds without local recurrence. Results were both functionally and aesthetically satisfactory.
   CONCLUSION The use of ADRT with vacuum-assisted closure followed by split-thickness skin grafting is an acceptable alternative to regional or free tissue transfer for reconstruction of complex Mohs defects.
C1 [Cunningham, Teresa; Marks, Malcolm] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Cunningham, T (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM tcunning@wakehealth.edu
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NR 17
TC 22
Z9 23
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-0512
EI 1524-4725
J9 DERMATOL SURG
JI Dermatol. Surg.
PD SEP
PY 2014
VL 40
IS 9
SU S
BP S120
EP S126
DI 10.1097/DSS.0000000000000113
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD4MP
UT WOS:000351057400013
PM 25158872
DA 2026-07-24
ER

PT J
AU Zeybek, B
   Li, SM
   Silberschmidt, VV
   Liu, Y
AF Zeybek, Begum
   Li, Simin
   Silberschmidt, Vadim V.
   Liu, Yang
TI Wound contraction under negative pressure therapy measured with digital
   image correlation and finite-element analysis in tissue phantoms and
   wound models
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Computational biomechanics; Negative pressure wound therapy; Wound
   phantoms; Soft tissue biomechanics; Deep tissue injuries
ID VACUUM-ASSISTED CLOSURE; MECHANICAL-BEHAVIOR; LOWER-LIMB; VALIDATION;
   MANAGEMENT; ADULTS; TOOL
AB The purpose of this study is to demonstrate the capabilities of finite-element (FE) models to predict contraction of wounds managed with negative pressure wound therapy (NPWT). The features of wounds and surrounding tissues were analysed to gain insights into the mechanical effects of NPWT on them. 3D digital image correlation (DIC) measurement of soft tissue phantoms was used to investigate the effect of wound thickness, size, and shape, which were further compared with results of FE simulations. It was noticed that with an increased NP level the difference between DIC and FE in wound contraction became more pronounced, particularly for the thick wounds. In addition, the locations of the wounds were evaluated to predict their contraction characteristics, based on surrounding tissue structures, in 3D using the developed FE models. It was demonstrated that features and location of wounds influenced their deformations differently for the same pressure levels. Overall, this study, involving a combined experimental and computational approach, allowed the important insights into mechanical effects of NPWT.
C1 [Zeybek, Begum; Li, Simin; Silberschmidt, Vadim V.; Liu, Yang] Loughborough Univ, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.
   [Liu, Yang] Loughborough Univ, Ctr Biol Engn, Loughborough, Leics, England.
   [Zeybek, Begum] Teesside Univ, Sch Hlth & Life Sci, Middlesbrough, Cleveland, England.
C3 Loughborough University; Loughborough University; University of Teesside
RP Liu, Y (通讯作者)，Loughborough Univ, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.; Liu, Y (通讯作者)，Loughborough Univ, Ctr Biol Engn, Loughborough, Leics, England.
EM Y.Liu@lboro.ac.uk
RI Liu, Yang/A-4046-2011; Li, Simin/A-8040-2015; Silberschmidt, Vadim
   V/G-7113-2011
OI Silberschmidt, Vadim V/0000-0003-3338-3311; Zeybek Saglam,
   Begum/0000-0001-6789-043X
FU Loughborough University, Wolfson School of Mechanical, Electrical and
   Manufacturing Engineering
FX This research was partially supported by Loughborough University,
   Wolfson School of Mechanical, Electrical and Manufacturing Engineering.
   We thank Thomas White, Assistant Professor, University of Nevada, Reno,
   USA for assistance with the DIC technique and providing his MATLAB
   source code, and Nelson Charles-Nwufoh (Loughborough University) for his
   assistance with the assessment of DIC measurement errors and improvement
   of the imaging system for the experiments.
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NR 57
TC 2
Z9 4
U1 0
U2 21
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD DEC
PY 2021
VL 98
BP 104
EP 114
DI 10.1016/j.medengphy.2021.11.003
EA NOV 2021
PG 11
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA YJ0VY
UT WOS:000744258300002
PM 34848029
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Maruccia, M
   Onesti, MG
   Sorvillo, V
   Albano, A
   Dessy, LA
   Carlesimo, B
   Tarallo, M
   Marcasciano, M
   Giudice, G
   Cigna, E
   Ribuffo, D
AF Maruccia, Michele
   Onesti, Maria G.
   Sorvillo, Valentina
   Albano, Antonio
   Dessy, Luca A.
   Carlesimo, Bruno
   Tarallo, Mauro
   Marcasciano, Marco
   Giudice, Giuseppe
   Cigna, Emanuele
   Ribuffo, Diego
TI An Alternative Treatment Strategy for Complicated Chronic Wounds:
   Negative Pressure Therapy over Mesh Skin Graft
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; COMBINATION; INTEGRA
AB Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. The aim of the study is to evaluate the improvement in wound healing given by the merger of these two different approaches. We treated 23 patients for large wounds of multiple factors. Of these, 15 were treated with the application of V. A. C. "Therapy (KCI Medical S. r. l., Milan, Italy), in combination with skin grafts after a prior unsuccessful treatment of 4 weeks with mesh skin grafts and dressings. Another 8 were treated with only mesh skin graft. Pain reduction and wound area reduction were found statistically significant (P< 0.0009,P< 0.0001). Infection was resolved in almost all patients. According to our study, the use of the negative pressure wound therapy over mesh skin grafts is significantly effective especially in wounds resistant to conventional therapies, thereby improving the rate of skin graft take.
C1 [Maruccia, Michele; Onesti, Maria G.; Sorvillo, Valentina; Albano, Antonio; Dessy, Luca A.; Carlesimo, Bruno; Tarallo, Mauro; Marcasciano, Marco; Cigna, Emanuele; Ribuffo, Diego] Sapienza Univ Rome, Valdoni Surg Dept, Plast & Reconstruct Surg Unit, Viale Policlin 155, I-00161 Rome, Italy.
   [Maruccia, Michele; Giudice, Giuseppe] Univ Bari Aldo Moro, Emergency & Organ Transplantat Dept, Plast & Reconstruct Surg & Burns Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Sapienza University Rome; Universita degli Studi di Bari Aldo Moro
RP Marcasciano, M (通讯作者)，Sapienza Univ Rome, Valdoni Surg Dept, Plast & Reconstruct Surg Unit, Viale Policlin 155, I-00161 Rome, Italy.
EM dott.marcomarcasciano@gmail.com
RI RIBUFFO, Diego/HLG-3305-2023; Marcasciano, Marco/HZJ-0259-2023; Tarallo,
   Mauro/AHD-1873-2022; Maruccia, Michele/ABE-9839-2020
OI RIBUFFO, Diego/0000-0002-1844-7850; 
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NR 17
TC 21
Z9 27
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 8395219
DI 10.1155/2017/8395219
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EN8BY
UT WOS:000396227100001
PM 28299333
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Or, M
   Van Goethem, B
   Kitshoff, A
   Koenraadt, A
   Schwarzkopf, I
   Bosmans, T
   de Rooster, H
AF Or, Matan
   Van Goethem, Bart
   Kitshoff, Adriaan
   Koenraadt, Annika
   Schwarzkopf, Ilona
   Bosmans, Tim
   de Rooster, Hilde
TI Negative pressure wound therapy using polyvinyl alcohol foam to bolster
   full-thickness mesh skin grafts in dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB ObjectiveTo report the use of negative pressure wound therapy (NPWT) with polyvinyl alcohol (PVA) foam to bolster full-thickness mesh skin grafts in dogs.
   Study DesignRetrospective case series.
   AnimalsClient-owned dogs (n=8).
   Material and MethodsFull-thickness mesh skin graft was directly covered with PVA foam. NPWT was maintained for 5 days (in 1 or 2 cycles). Grafts were evaluated on days 2, 5, 10, 15, and 30 for graft appearance and graft take, granulation tissue formation, and complications.
   ResultsFirm attachment of the graft to the recipient bed was accomplished in 7 dogs with granulation tissue quickly filling the mesh holes, and graft take considered excellent. One dog had bandage complications after cessation of the NPWT, causing partial graft loss. The PVA foam did not adhere to the graft or damage the surrounding skin.
   ConclusionThe application of NPWT with a PVA foam after full-thickness mesh skin grafting in dogs provides an effective method for securing skin grafts, with good graft acceptance. PVA foam can be used as a primary dressing for skin grafts, obviating the need for other interposing materials to protect the graft and the surrounding skin.
C1 [Or, Matan; Van Goethem, Bart; Kitshoff, Adriaan; Koenraadt, Annika; Schwarzkopf, Ilona; Bosmans, Tim; de Rooster, Hilde] Univ Ghent, Small Anim Dept, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
   [Schwarzkopf, Ilona] DAC Malpertuus, Heusden, Belgium.
C3 Ghent University
RP Or, M (通讯作者)，Univ Ghent, Small Anim Dept, Fac Vet Med, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM matanor5@gmail.com
RI de Rooster, Hilde/AAX-9497-2020; Kitshoff, Adriaan/AFS-4979-2022; Van
   Goethem, Bart/AAM-7175-2020
OI de Rooster, Hilde/0000-0001-8087-256X; Kitshoff,
   Adriaan/0000-0001-9657-740X; 
CR [Anonymous], V A C THER CLIN GUID
   [Anonymous], V A C THER VET US US
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NR 20
TC 14
Z9 16
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD APR
PY 2017
VL 46
IS 3
BP 389
EP 395
DI 10.1111/vsu.12613
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA ER3BA
UT WOS:000398668100009
PM 28151546
DA 2026-07-24
ER

PT J
AU Streubel, PN
   Stinner, DJ
   Obremskey, WT
AF Streubel, Philipp N.
   Stinner, Daniel J.
   Obremskey, William T.
TI Use of Negative-pressure Wound Therapy in Orthopaedic Trauma
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SEALING-TECHNIQUE; OPEN
   FRACTURES; TRIAL; CONTAMINATION; INFECTIONS; EXPERIENCE; MANAGEMENT;
   DRESSINGS
AB Negative-pressure wound therapy (NPWT) has become an important adjunct to the management of traumatic wounds and surgical incisions related to musculoskeletal trauma. On the battlefield, this adjunct therapy allows early wound management and safe aeromedical evacuation. NPWT mechanisms of action include stabilization of the wound environment, reduction of wound edema, improvement of tissue perfusion, and stimulation of cells at the wound surface. NPWT stimulates granulation tissue and angiogenesis and may improve the likelihood of primary closure and reduce the need for free tissue transfer. In addition, NPWT reduces the bacterial bioburden of wounds contaminated with gram-negative bacilli. However, an increased risk of colonization of gram-positive cocci (eg, Staphylococcus aureus) exists. Although NPWT facilitates wound management, further research is required to determine conclusively whether this modality is superior to other management options. Ongoing research will continue to define the indications for and benefits of NPWT as well as establish the role of combination therapy, in which NPWT is used with instillation of antibiotic solutions, placement of antibiotic-laden cement beads, or silver-impregnated sponges.
C1 [Streubel, Philipp N.; Obremskey, William T.] Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA.
   [Stinner, Daniel J.] Brooke Army Med Ctr, San Antonio, TX USA.
C3 Vanderbilt University; United States Department of Defense; United
   States Army; Brooke Army Medical Center
RP Streubel, PN (通讯作者)，Vanderbilt Univ, Ctr Med, Div Orthopaed Trauma, Nashville, TN 37232 USA.
RI Stinner, Daniel/KSM-9513-2024; Obremskey, William/HRA-4704-2023
OI Stinner, Daniel/0000-0002-8981-6262; Obremskey,
   William/0000-0002-8942-1842; Streubel, Philipp/0000-0002-4585-1779
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NR 41
TC 74
Z9 90
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD SEP
PY 2012
VL 20
IS 9
BP 564
EP 574
DI 10.5435/JAAOS-20-09-564
PG 11
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 000JK
UT WOS:000308382400003
PM 22941799
DA 2026-07-24
ER

PT J
AU Elkhatib, R
   Giunta, G
   Hanssens, V
   Kapila, A
   De Baerdemaeker, R
   Zeltzer, A
   Hamdi, M
AF Elkhatib, Rania
   Giunta, Gabriele
   Hanssens, Valerie
   Kapila, Ayush
   De Baerdemaeker, Randy
   Zeltzer, Assaf
   Hamdi, Moustapha
TI Case Report of Two Patients With COVID-19 and Sacral Pressure Injuries
   Associated with Pyoderma Gangrenosum
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Editorial Material
DE COVID-19; negative-pressure wound therapy; pyoderma gangrenosum;
   pressure injuries; vacuum-assisted closure
ID VACUUM-ASSISTED CLOSURE; ULCERS
AB During the COVID-19 pandemic, an increasing number of patients have been admitted to the ICU with severe respiratory complications requiring prolonged supine positioning. Recently, many case reports have been published regarding dermatologic manifestations associated with COVID-19. However, there is little information about the clinical features of these manifestations. Pyoderma gangrenosum (PG) is an ulcerative noninfectious inflammatory disease of the skin. In at least 50% of the cases, the etiology is unknown. Nevertheless, PG is associated with many systemic diseases. In this article, the authors report two critically ill patients with COVID-19 who developed sacral ulcers during their recovery in the ICU. These ulcers had an atypical course and were exacerbated by surgical debridements. Accordingly, providers suspected PG, which was confirmed by the clinical evolution of the ulcers and biopsies taken from the wounds. To the best of the authors' knowledge, no previous articles have reported sacral pressure injuries associated with PG in patients with COVID-19. Providers should suspect PG in patients with COVID-19 who develop nonhealing pressure injuries.
C1 [Elkhatib, Rania; Giunta, Gabriele; Hanssens, Valerie; Kapila, Ayush; De Baerdemaeker, Randy; Zeltzer, Assaf; Hamdi, Moustapha] Univ Hosp Brussels, Dept Plast & Reconstruct Surg, Brussels, Belgium.
C3 University Hospital Brussels
RP Elkhatib, R (通讯作者)，Univ Hosp Brussels, Dept Plast & Reconstruct Surg, Brussels, Belgium.
RI ; Kapila, Ayush/AAU-4940-2020
OI Hanssens, Valerie/0009-0001-5113-7336; GIUNTA,
   GABRIELE/0000-0002-2547-2851; Kapila, Ayush/0000-0003-3523-7924
CR [Anonymous], 2022, tics of coronavirus disease 2019: Technologies and application
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NR 29
TC 3
Z9 3
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2021
VL 34
IS 8
BP 438
EP 443
DI 10.1097/01.ASW.0000744356.54317.c2
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA TM2DL
UT WOS:000675361900012
PM 33871408
DA 2026-07-24
ER

PT J
AU Saab, IR
   Sarhane, KA
   Ezzeddine, HM
   Abu-Sittah, GS
   Ibrahim, AE
AF Saab, I. R.
   Sarhane, K. A.
   Ezzeddine, H. M.
   Abu-Sittah, G. S.
   Ibrahim, A. E.
TI Treatment of a paediatric patient with a distal lower extremity
   traumatic wound using a dermal regeneration template and NPWT
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE degloving injury; dermal regeneration template; integra; lower extremity
   reconstruction; negative pressure wound therapy; vacuum-assisted closure
ID RECONSTRUCTIVE SURGERY; ARTIFICIAL DERMIS; INTEGRA; MANAGEMENT; SKIN;
   SUBSTITUTE; EXPERIENCE; MATRIX
AB Degloving injuries are common in trauma and represent a spectrum of complex wounds, the management of which may be highly challenging especially in the paediatric population. In severe injuries leading to wounds reaching tendon and bone, vascularity is compromised precluding traditional wound management, and sometimes necessitating amputation. This report highlights the use of a dermal regeneration template combined with vacuum-assisted closure (VAC) in the treatment of complex traumatic degloving wounds. Here, we present a case of a five-year-old boy who sustained a high-energy shear injury to his lower extremity that resulted in an extensive degloving wound involving the distal third of his leg and the dorsum of his foot.After debridement, the patient underwent VAC combined with a dermal skin substitute placement, followed by split-thickness skin grafting. The extremity healed with no complications and without the need for amputation or flap reconstruction, achieving satisfactory recovery of range of motion and favourable cosmetic results.
C1 [Saab, I. R.; Sarhane, K. A.; Ezzeddine, H. M.; Abu-Sittah, G. S.; Ibrahim, A. E.] Amer Univ Beirut, Dept Surg, Div Plast & Reconstruct Surg, Beirut, Lebanon.
C3 American University of Beirut
RP Saab, IR (通讯作者)，Amer Univ Beirut, Dept Surg, Div Plast & Reconstruct Surg, Beirut, Lebanon.
EM karim.sarhane@yahoo.com
RI Abu-Sittah, Ghassan/AAE-3169-2020; SERHAN, Karim/CAG-5222-2022
OI SERHAN, Karim/0000-0003-4458-4047
CR Corporation I. L., 2010, INTEGRA DERM REG TEM
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NR 30
TC 8
Z9 11
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2014
VL 23
IS 10
BP S5
EP S8
DI 10.12968/jowc.2014.23.Sup10.S5
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AQ6XZ
UT WOS:000342958500006
PM 25289652
DA 2026-07-24
ER

PT J
AU Wu, SC
   Marston, W
   Armstrong, DG
AF Wu, Stephanie C.
   Marston, William
   Armstrong, David G.
TI Wound Care The Role of Advanced Wound-healing Technologies
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID DIABETIC FOOT ULCERS; HYPERBARIC-OXYGEN THERAPY;
   RANDOMIZED-CONTROLLED-TRIAL; HUMAN SKIN EQUIVALENT; VACUUM-ASSISTED
   CLOSURE; LOWER-EXTREMITY ULCERS; MARROW-DERIVED CELLS;
   COST-EFFECTIVENESS; MULTICENTER; CULTURE
AB Wound repair and regeneration is a highly complex combination of matrix destruction and reorganization. Although major hurdles remain, advances during the past generation have improved the clinician's armamentarium in the medical and surgical management of this problem. The purpose of this article is to review the current literature regarding the pragmatic use of three of the most commonly used advanced therapies: bioengineered tissue, negative-pressure wound therapy, and hyperbaric oxygen therapy, with a focus on the near-term future of wound healing, including stem cell therapy. (J Am Podiatr Med Assoc 100(5): 385-394, 2010)
C1 [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, N Chicago, IL 60064 USA.
   [Marston, William] Univ N Carolina, Sch Med, Div Vasc Surg, Wound Healing Limb Preservat Ctr, Chapel Hill, NC USA.
   [Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, Tucson, AZ USA.
C3 Rosalind Franklin University of Medicine & Science; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; University of Arizona
RP Wu, SC (通讯作者)，Rosalind Franklin Univ Med & Sci, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
EM stephanie.wu@rosalindfranklin.edu
CR Abidia A, 2003, EUR J VASC ENDOVASC, V25, P513, DOI 10.1053/ejvs.2002.1911
   Allenet B, 2000, DIABETES METAB, V26, P125
   [Anonymous], COCHRANE DATABASE SY
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong David G, 2004, Int J Low Extrem Wounds, V3, P184, DOI 10.1177/1534734604271963
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Badiavas EV, 2003, ARCH DERMATOL, V139, P510, DOI 10.1001/archderm.139.4.510
   Badiavas EV, 2007, WOUND REPAIR REGEN, V15, P856, DOI 10.1111/j.1524-475X.2007.00305.x
   Bauer SM, 2006, J VASC SURG, V43, P134, DOI 10.1016/j.jvs.2005.08.038
   Bello Y M, 2001, Am J Clin Dermatol, V2, P305, DOI 10.2165/00128071-200102050-00005
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Brem H, 2001, DERMATOL SURG, V27, P915, DOI 10.1046/j.1524-4725.2001.01092.x
   Brem H, 2000, ARCH SURG-CHICAGO, V135, P627, DOI 10.1001/archsurg.135.6.627
   Browne A C, 2001, Ostomy Wound Manage, V47, P44
   Cavanagh PR, 2005, LANCET, V366, P1725, DOI 10.1016/S0140-6736(05)67699-4
   Chuck AW, 2008, INT J TECHNOL ASSESS, V24, P178, DOI 10.1017/S0266462308080252
   De Sumit K, 2002, J AM PODIAT MED ASSN, V92, P19, DOI 10.7547/87507315-92-1-19
   Deng J, 2006, STEM CELLS, V24, P1054, DOI 10.1634/stemcells.2005-0370
   Dolynchuk K, 1999, Ostomy Wound Manage, V45, P34
   Donohue KG, 2005, J DERMATOL, V32, P626, DOI 10.1111/j.1346-8138.2005.tb00811.x
   Edmonds M, 2009, INT J LOW EXTR WOUND, V8, P11, DOI 10.1177/1534734609331597
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fagrell B, 1999, VASC MED, V4, P125, DOI 10.1177/1358836X9900400301
   Falanga V, 2000, WOUND REPAIR REGEN, V8, P347
   Falanga V, 2007, TISSUE ENG, V13, P1299, DOI 10.1089/ten.2006.0278
   Fathke C, 2004, STEM CELLS, V22, P812, DOI 10.1634/stemcells.22-5-812
   Fife CE, 2002, WOUND REPAIR REGEN, V10, P198, DOI 10.1046/j.1524-475X.2002.10402.x
   Gentzkow GD, 1996, DIABETES CARE, V19, P350, DOI 10.2337/diacare.19.4.350
   Goldman RJ, 2009, PM&R, V1, P471, DOI 10.1016/j.pmrj.2009.03.012
   Grolman RE, 2001, AM SURGEON, V67, P1072
   Hanft Jason R, 2002, J Foot Ankle Surg, V41, P291
   Kalani M, 2002, J DIABETES COMPLICAT, V16, P153, DOI 10.1016/S1056-8727(01)00182-9
   Kuffler DP, 2010, J WOUND CARE, V19, P77, DOI 10.12968/jowc.2010.19.2.46970
   Langer A, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-115
   Lee KH, 2000, YONSEI MED J, V41, P774, DOI 10.3349/ymj.2000.41.6.774
   Löndahl M, 2010, DIABETES CARE, V33, P998, DOI 10.2337/dc09-1754
   Mansbridge J, 1998, TISSUE ENG, V4, P403, DOI 10.1089/ten.1998.4.403
   Mansbridge J, 1998, Expert Opin Investig Drugs, V7, P803, DOI 10.1517/13543784.7.5.803
   Marston WA, 2006, OSTOMY WOUND MANAG, V52, P26
   Marston WA, 2004, EXPERT REV MED DEVIC, V1, P21, DOI 10.1586/17434440.1.1.21
   Marston WA, 2003, DIABETES CARE, V26, P1701, DOI 10.2337/diacare.26.6.1701
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   McFarlin K, 2006, WOUND REPAIR REGEN, V14, P471, DOI 10.1111/j.1743-6109.2006.00153.x
   Mustoe TA, 2006, PLAST RECONSTR SURG, V117, p35S, DOI 10.1097/01.prs.0000225431.63010.1b
   Newton D J, 2002, J Foot Ankle Surg, V41, P233
   Paquette D, 2002, CLIN GERIATR MED, V18, P77, DOI 10.1016/S0749-0690(03)00035-1
   Redekop WK, 2003, PHARMACOECONOMICS, V21, P1171, DOI 10.2165/00019053-200321160-00003
   STEED DL, 1995, J VASC SURG, V21, P71, DOI 10.1016/S0741-5214(95)70245-8
   Steinberg John S, 2010, J Am Podiatr Med Assoc, V100, P73
   Trent JF, 1998, INT J CLIN PRACT, V52, P408
   Veves A, 2002, ARCH SURG-CHICAGO, V137, P822, DOI 10.1001/archsurg.137.7.822
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
   Zaulyanov L, 2007, CLIN INTERV AGING, V2, P93, DOI 10.2147/ciia.2007.2.1.93
   1998, DRUG NEWS PERSPECT, V11, P43
   2000, ADV SKIN WOUND CAR S, V13, P4
NR 56
TC 36
Z9 46
U1 0
U2 13
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2010
VL 100
IS 5
BP 385
EP 394
DI 10.7547/1000385
PG 10
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 655LF
UT WOS:000282250800009
PM 20847352
DA 2026-07-24
ER

PT J
AU Wu, SC
   Marston, W
   Armstrong, DG
AF Wu, Stephanie C.
   Marston, William
   Armstrong, David G.
TI Wound care: The role of advanced wound healing technologies
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID DIABETIC FOOT ULCERS; HYPERBARIC-OXYGEN THERAPY;
   RANDOMIZED-CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY
   ULCERS; HUMAN SKIN EQUIVALENT; MARROW-DERIVED CELLS; COST-EFFECTIVENESS;
   MULTICENTER; CULTURE
AB Wound repair and regeneration is a highly complex combination of matrix destruction and reorganization. While major hurdles remain, advances over the past generation have improved the clinician's armamentarium in the medical and surgical management of this problem. The purpose of this manuscript is to review the current literature regarding the pragmatic use of three of the most commonly employed advanced therapies; namely, bioengineered tissue, negative pressure wound therapy, and hyperbaric oxygen therapy with a focus on the near-term future of wound healing, including stem cell therapy. (J Vase Surg 2010;52:59S-66S.)
C1 [Armstrong, David G.] Univ Arizona, Coll Med, Dept Surg, SALSA, Tucson, AZ 85724 USA.
   [Wu, Stephanie C.] Rosalind Franklin Univ Med & Sci, N Chicago, IL USA.
   [Marston, William] Univ N Carolina, Sch Med, Dept Surg, Vasc Surg Sect, Chapel Hill, NC USA.
C3 University of Arizona; Rosalind Franklin University of Medicine &
   Science; University of North Carolina; University of North Carolina
   Chapel Hill; University of North Carolina School of Medicine
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, Dept Surg, SALSA, Tucson, AZ 85724 USA.
EM armstrong@usa.net
CR Abidia A, 2003, EUR J VASC ENDOVASC, V25, P513, DOI 10.1053/ejvs.2002.1911
   Allenet B, 2000, DIABETES METAB, V26, P125
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Armstrong David G, 2004, Int J Low Extrem Wounds, V3, P184, DOI 10.1177/1534734604271963
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Badiavas EV, 2003, ARCH DERMATOL, V139, P510, DOI 10.1001/archderm.139.4.510
   Badiavas EV, 2007, WOUND REPAIR REGEN, V15, P856, DOI 10.1111/j.1524-475X.2007.00305.x
   Bauer SM, 2006, J VASC SURG, V43, P134, DOI 10.1016/j.jvs.2005.08.038
   Bello Y M, 2001, Am J Clin Dermatol, V2, P305, DOI 10.2165/00128071-200102050-00005
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Brem H, 2001, DERMATOL SURG, V27, P915, DOI 10.1046/j.1524-4725.2001.01092.x
   Brem H, 2000, ARCH SURG-CHICAGO, V135, P627, DOI 10.1001/archsurg.135.6.627
   Browne A C, 2001, Ostomy Wound Manage, V47, P44
   Cavanagh PR, 2005, LANCET, V366, P1725, DOI 10.1016/S0140-6736(05)67699-4
   Chuck AW, 2008, INT J TECHNOL ASSESS, V24, P178, DOI 10.1017/S0266462308080252
   De Sumit K, 2002, J AM PODIAT MED ASSN, V92, P19, DOI 10.7547/87507315-92-1-19
   Deng J, 2006, STEM CELLS, V24, P1054, DOI 10.1634/stemcells.2005-0370
   Dolynchuk K, 1999, Ostomy Wound Manage, V45, P34
   Donohue KG, 2005, J DERMATOL, V32, P626, DOI 10.1111/j.1346-8138.2005.tb00811.x
   Edmonds M, 2009, INT J LOW EXTR WOUND, V8, P11, DOI 10.1177/1534734609331597
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fagrell B, 1999, VASC MED, V4, P125, DOI 10.1177/1358836X9900400301
   Falanga V, 2000, WOUND REPAIR REGEN, V8, P347
   Falanga V, 2007, TISSUE ENG, V13, P1299, DOI 10.1089/ten.2006.0278
   Fathke C, 2004, STEM CELLS, V22, P812, DOI 10.1634/stemcells.22-5-812
   Fife CE, 2002, WOUND REPAIR REGEN, V10, P198, DOI 10.1046/j.1524-475X.2002.10402.x
   Gentzkow GD, 1996, DIABETES CARE, V19, P350, DOI 10.2337/diacare.19.4.350
   Goldman RJ, 2009, PM&R, V1, P471, DOI 10.1016/j.pmrj.2009.03.012
   Grolman RE, 2001, AM SURGEON, V67, P1072
   Hanft Jason R, 2002, J Foot Ankle Surg, V41, P291
   Kalani M, 2002, J DIABETES COMPLICAT, V16, P153, DOI 10.1016/S1056-8727(01)00182-9
   Kranke P, 2004, Cochrane Database Syst Rev, pCD004123
   Kuffler DP, 2010, J WOUND CARE, V19, P77, DOI 10.12968/jowc.2010.19.2.46970
   Langer A, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-115
   Lee KH, 2000, YONSEI MED J, V41, P774, DOI 10.3349/ymj.2000.41.6.774
   Löndahl M, 2010, DIABETES CARE, V33, P998, DOI 10.2337/dc09-1754
   Mansbridge J, 1998, TISSUE ENG, V4, P403, DOI 10.1089/ten.1998.4.403
   Mansbridge J, 1998, Expert Opin Investig Drugs, V7, P803, DOI 10.1517/13543784.7.5.803
   Marston WA, 2006, OSTOMY WOUND MANAG, V52, P26
   Marston WA, 2004, EXPERT REV MED DEVIC, V1, P21, DOI 10.1586/17434440.1.1.21
   Marston WA, 2003, DIABETES CARE, V26, P1701, DOI 10.2337/diacare.26.6.1701
   MCCALLON S.K., 2000, Ostomy Wound Manage, V46, P28
   McFarlin K, 2006, WOUND REPAIR REGEN, V14, P471, DOI 10.1111/j.1743-6109.2006.00153.x
   Mustoe TA, 2006, PLAST RECONSTR SURG, V117, p35S, DOI 10.1097/01.prs.0000225431.63010.1b
   Newton D J, 2002, J Foot Ankle Surg, V41, P233
   Paquette D, 2002, CLIN GERIATR MED, V18, P77, DOI 10.1016/S0749-0690(03)00035-1
   Redekop WK, 2003, PHARMACOECONOMICS, V21, P1171, DOI 10.2165/00019053-200321160-00003
   STEED DL, 1995, J VASC SURG, V21, P71, DOI 10.1016/S0741-5214(95)70245-8
   Steinberg John S, 2010, J Am Podiatr Med Assoc, V100, P73
   Trent JF, 1998, INT J CLIN PRACT, V52, P408
   Veves A, 2002, ARCH SURG-CHICAGO, V137, P822, DOI 10.1001/archsurg.137.7.822
   Veves A, 2001, DIABETES CARE, V24, P290, DOI 10.2337/diacare.24.2.290
   Zaulyanov L, 2007, CLIN INTERV AGING, V2, P93, DOI 10.2147/ciia.2007.2.1.93
   1998, DRUG NEWS PERSPECT, V11, P43
   2000, ADV SKIN WOUND CAR S, V13, P4
NR 56
TC 48
Z9 62
U1 0
U2 20
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD SEP
PY 2010
VL 52
SU S
BP 59S
EP 66S
DI 10.1016/j.jvs.2010.06.009
PG 8
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 646VC
UT WOS:000281570200009
PM 20804934
DA 2026-07-24
ER

PT J
AU Chariker, ME
   Handsaker, J
   McCarthy, C
AF Chariker, Mark E.
   Handsaker, Joanne
   McCarthy, Catherine
TI Removing the Complexities Associated with Traditional Negative Pressure
   Wound Therapy (tNPWT) Bridging Applications
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE bridging technique; hard port; negative pressure wound therapy; soft
   port
ID VACUUM-ASSISTED CLOSURE
AB Background. Negative pressure wound therapy (NPWT) is an effective intervention for challenging wounds across multiple indications. Its application sometimes requires a technique known as 'bridging" to prevent ulcerations caused by delivery port and tubing when positioning the device, which requires extra time and resources. The bridging technique may be adopted when it is considered essential to move the NPWT delivery port away from the wound bed or when treating wounds in close proximity to each other. Materials and Methods. A survey was undertaken by 200 health care professionals (HCPs) in the United States who are experienced in utilizing traditional negative pressure wound therapy (tNPWT) and bridging. Primary objectives were to explore HCP opinion on 2 types of tNPWT delivery ports (soft and hard) between 2 leading manufacturers. Questions focused on the need for bridging, alleviation of complexity in application, and reducing concerns relating to medical device-related pressure injury when applied to awkward anatomical areas. Results. HCPs (75%; n=150) largely agreed that the bridging technique makes application of tNPWT slightly more challenging. Reasons included additional time taken to apply (74%; n=148), increased dressing resource (67%; n=13 4), and additional staff required (50%; n=100). Over half (53%; n=106) agreed that the soft port can eliminate the need for bridging. The majority of wound specialists were significantly less likely to favor a hard port (58%; n=116). Two further potential benefits of using a tNPWT soft port include the associated risk of pain/pressure when applying a hard port over a smaller wound size (29%; n=58) and certain anatomical areas which pose a risk of pressure injury or kinked/twisted tubing (31%; n=62). Conclusion. tNPWT soft ports remain effective regardless of kinks or twists and can eliminate bridging in anatomical areas where patients may weight-bear on tubing or delivery ports, saving time and decreasing risks of periwound trauma.
C1 [Chariker, Mark E.] Norton Childrens Hosp, Dept Craniofacial & Pediat Plast Surg, Louisville, KY USA.
   [Handsaker, Joanne; McCarthy, Catherine] Smith & Nephew, Global Clin Strategy Adv Wound Management, Watford, England.
RP McCarthy, C (通讯作者)，Smith & Nephew, Watford WD18 8YE, England.
EM catherine.mccarthy@smith-nephew.com
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Borys S, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13067
   Brophy S, 2021, J TISSUE VIABILITY, V30, P489, DOI 10.1016/j.jtv.2021.03.002
   Brownhill VR, 2021, ADV WOUND CARE, V10, P345, DOI 10.1089/wound.2020.1218
   Caputo GG, 2019, J ORTHOP TRAUMA, V33, pE24, DOI 10.1097/BOT.0000000000001281
   Choi WW, 2011, PEDIATR SURG INT, V27, P907, DOI 10.1007/s00383-011-2868-6
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   Jackson D, 2019, INT J NURS STUD, V92, P109, DOI 10.1016/j.ijnurstu.2019.02.006
   Keenan C, 2025, ADV WOUND CARE, V14, P33, DOI 10.1089/wound.2023.0157
   Kirsner R, 2019, WOUND REPAIR REGEN, V27, P519, DOI 10.1111/wrr.12727
   Liebman RM, 2023, SEMIN PLAST SURG, V37, P9, DOI 10.1055/s-0042-1759562
   Nather A, 2010, ANN ACAD MED SINGAP, V39, P353
   Normandin S, 2021, SEMIN PLAST SURG, V35, P164, DOI 10.1055/s-0041-1731792
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   Smith+Nephew, 2020, Pressure Redistribution Testing of RENASYS Softport against SensaT.R.A.C. Data on file
   The Joint Commission Division of Healthcare Improvement, 2018, QUICK SAFETY, V43, P1
NR 25
TC 0
Z9 0
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2025
VL 37
IS 3
BP 107
EP 113
DI 10.25270/wnds/24074
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 1YJ9N
UT WOS:001476594100002
PM 40215360
DA 2026-07-24
ER

PT J
AU Garten, A
   Nherera, LM
   Lindsay, R
AF Garten, Alison
   Nherera, Leo M.
   Lindsay, Rodney
TI Comparison of Single Use and Traditional Negative Pressure Wound Therapy
   Devices in Lower Extremity Ulcers: A US Real-World Evidence Analysis of
   NetHealth Data
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE diabetic foot ulcer; lower extremity ulcer; single-use negative pressure
   wound therapy; traditional negative pressure wound therapy; venous leg
   ulcer
ID DIABETIC FOOT ULCERS; VACUUM-ASSISTED CLOSURE; VENOUS LEG ULCERS; COST;
   BURDEN; CLASSIFICATION; MANAGEMENT; MEDICARE; SOCIETY; UPDATE
AB Annually, 49 million people worldwide are impacted by lower extremity ulcers (LEUs). Diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are the most common LEUs. Negative pressure wound therapy (NPWT) has emerged as an effective intervention for complex wounds, offering numerous favourable wound healing outcomes. The objective of this study was to evaluate the effectiveness of single-use NPWT (sNPWT) versus traditional NPWT (tNPWT) for wound closure in LEUs. Real-world data was obtained from the US-based Net Health outpatient database between January 2014 and October 2020 and included patients with LEUs (DFU or VLU) who had been treated with sNPWT or tNPWT. The rate of wound closure and time to wound closure were selected as endpoints. The wound closure rate was significantly higher for all LEUs (p = 0.039), VLUs alone (p = 0.003) and there was no difference for DFU (p = 0.90) that were treated with sNPWT versus tNPWT. The median time to wound closure was significantly shorter for sNPWT (114 days) compared to tNPWT (140 days, p < 0.01). Using sNPWT was associated with significantly higher wound closure rates and shorter time to wound closure. The results provide supportive evidence for using sNPWT for LEUs, demonstrating the opportunity to directly decrease the clinical burden of LEUs on patients. Subgroup analysis revealed a significant difference in wound closure rates for VLU, while no significant difference was observed for DFU. The overall LEU findings may be attributed to differences in the mechanisms of action between the two devices.
C1 [Garten, Alison] Charlotte Limb Preservat & Diabetic Foot Ctr, Charlotte, NC 28210 USA.
   [Nherera, Leo M.] Smith Nephew Inc, Ft Worth, TX USA.
   [Lindsay, Rodney] Carrollton Reg Med Ctr, Carrollton, TX USA.
C3 Smith & Nephew
RP Garten, A (通讯作者)，Charlotte Limb Preservat & Diabetic Foot Ctr, Charlotte, NC 28210 USA.
EM drgartenaawp@gmail.com
FU Smith and Nephew Inc.
FX This study was funded by Smith and Nephew Inc.
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2007, Int Wound J, V4, P79, DOI 10.1111/j.1742-481X.2006.00270.x
   Armstrong DG, 2020, J FOOT ANKLE RES, V13, DOI 10.1186/s13047-020-00383-2
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD SEP 4
PY 2025
VL 22
IS 9
AR e70756
DI 10.1111/iwj.70756
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA E9421
UT WOS:001623043700001
PM 40908001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hsu, KF
   Kao, LT
   Chu, PY
   Chen, CY
   Chou, YY
   Huang, DW
   Liu, TH
   Tsai, SL
   Wu, CW
   Hou, CC
   Wang, CH
   Dai, NT
   Chen, SG
   Tzeng, YS
AF Hsu, Kuo-Feng
   Kao, Li-Ting
   Chu, Pei-Yi
   Chen, Chun-Yu
   Chou, Yu-Yu
   Huang, Dun-Wei
   Liu, Ting-Hsuan
   Tsai, Sheng-Lin
   Wu, Chien-Wei
   Hou, Chih-Chun
   Wang, Chih-Hsin
   Dai, Niann-Tzyy
   Chen, Shyi-Gen
   Tzeng, Yuan-Sheng
TI Simple and Efficient Pressure Ulcer Reconstruction via Primary Closure
   Combined with Closed-Incision Negative Pressure Wound Therapy
   (CiNPWT)-Experience of a Single Surgeon
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE pressure ulcer; surgical reconstruction; dressing materials; wound
   control; negative pressure wound therapy; vacuum-assisted closure;
   closed-incision negative pressure wound therapy; closed-incision
   negative pressure therapy
ID ARTERY PERFORATOR FLAP; GENERAL-ANESTHESIA; OPEN ABDOMEN; MANAGEMENT;
   METAANALYSIS; PERFUSION; DEFECTS; SUTURES; SORES; CARE
AB Background: In this study, we aimed to analyze the clinical efficacy of closed-incision negative pressure wound therapy (CiNPWT) when combined with primary closure (PC) in a patient with pressure ulcers, based on one single surgeon's experience at our medical center. Methods: We retrospectively reviewed the data of patients with stage III or IV pressure ulcers who underwent reconstruction surgery. Patient characteristics, including age, sex, cause and location of defect, comorbidities, lesion size, wound reconstruction methods, operation time, debridement times, application of CiNPWT to reconstructed wounds, duration of hospital stay, and wound complications were analyzed. Results: Operation time (38.16 +/- 14.02 vs. 84.73 +/- 48.55 min) and duration of hospitalization (36.78 +/- 26.92 vs. 56.70 +/- 58.43 days) were shorter in the PC + CiNPWT group than in the traditional group. The frequency of debridement (2.13 +/- 0.98 vs. 2.76 +/- 2.20 times) was also lower in the PC + CiNPWT group than in the traditional group. The average reconstructed wound size did not significantly differ between the groups (63.47 +/- 42.70 vs. 62.85 +/- 49.94 cm(2)), and there were no significant differences in wound healing (81.25% vs. 75.38%), minor complications (18.75% vs. 21.54%), major complications (0% vs. 3.85%), or mortality (6.25% vs. 10.00%) between the groups. Conclusions: Our findings indicate that PC combined with CiNPWT represents an alternative reconstruction option for patients with pressure ulcers, especially in those for whom prolonged anesthesia is unsuitable.
C1 [Hsu, Kuo-Feng; Chen, Chun-Yu; Chou, Yu-Yu; Huang, Dun-Wei; Liu, Ting-Hsuan; Tsai, Sheng-Lin; Wu, Chien-Wei; Hou, Chih-Chun; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114202, Taiwan.
   [Hsu, Kuo-Feng; Chu, Pei-Yi; Chen, Chun-Yu; Chou, Yu-Yu; Huang, Dun-Wei; Liu, Ting-Hsuan; Tsai, Sheng-Lin; Wu, Chien-Wei; Hou, Chih-Chun; Wang, Chih-Hsin; Dai, Niann-Tzyy; Chen, Shyi-Gen; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114202, Taiwan.
   [Kao, Li-Ting] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pharm Practice, Taipei 114202, Taiwan.
   [Kao, Li-Ting] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114202, Taiwan.
C3 National Defense Medical University; Tri-Service General Hospital;
   Tri-Service General Hospital; National Defense Medical University;
   National Defense Medical University; Tri-Service General Hospital;
   National Defense Medical University
RP Tzeng, YS (通讯作者)，Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Taipei 114202, Taiwan.; Tzeng, YS (通讯作者)，Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114202, Taiwan.
EM captain0416@gmail.com; kaoliting@gmail.com; chu.peiyi.88@gmail.com;
   illusioncjy@gmail.com; justyu1112@gmail.com; gdream12731@gmail.com;
   liutingxuan@gmail.com; woodytsai2012@gmail.com;
   alex199180220@hotmail.com; i0937361709@hotmail.com;
   super-derrick@yahoo.com.tw; niantzyydai@gmail.com; shyigen@gmail.com;
   m6246kimo@yahoo.com.tw
RI ; Tzeng, Yuan-sheng/AAD-8843-2020; Kao, Li-Ting/W-9287-2018
OI Hou, Chih-Chun/0000-0002-7179-0551; Chu, Pei-yi/0000-0002-6905-7895;
   Tsai, Sheng-Lin/0000-0002-1591-1865; Wu, Chien-Wei/0000-0001-8798-2403;
   Liu, Ting-Hsuan/0000-0002-1482-978X; Tzeng,
   Yuan-sheng/0000-0002-8440-2351; Huang, Dun-Wei/0000-0002-5320-2517; Hsu,
   Kuo-Feng/0000-0002-6883-1295; Kao, Li-Ting/0000-0003-0692-7408
FU Tri-Service General Hospital [TSGH-E-110217 and TSGH-D-111124] Funding
   Source: Medline
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NR 54
TC 10
Z9 11
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2022
VL 12
IS 2
AR 182
DI 10.3390/jpm12020182
PG 16
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA ZU2XX
UT WOS:000769708700001
PM 35207670
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Faurschou, IK
   Sorensen, MJ
   Pedersen, AG
   Rasmussen, SL
   Erichsen, R
   Haas, S
AF Faurschou, Ida Kaad
   Sorensen, Marlene Julia
   Pedersen, Allan Gorm
   Rasmussen, Simon Ladefoged
   Erichsen, Rune
   Haas, Susanne
TI Closed-incision negative-pressure wound therapy after Bascom's cleft
   lift surgery for pilonidal sinus disease: A randomized study comparing
   healing
SO COLORECTAL DISEASE
LA English
DT Article
DE Bascom cleft lift; ciNPT; cleft lift surgery; negative-pressure wound
   therapy; non-healing wound; pilonidal disease; pilonidal sinus;
   pilonidal sinus disease; pilonidal surgery; recurrent pilonidal disease;
   surgical flaps; vacuum-assisted closure
AB AimDespite favourable outcomes in recurrence after off-midline closure techniques in pilonidal surgery, between 18% and 40% of patients suffer from prolonged postoperative wound healing. The aim of this work was to investigate if closed-incision negative-pressure wound therapy (NPWT) promotes wound healing after Bascom's cleft lift (BCL) surgery for complicated pilonidal sinus disease compared with conventional drainage and dressing.MethodPatients were randomized to either NPWT for 4-7 days or loop-vessel drain for 24 h and a dry dressing postoperatively. Healing was evaluated by a wound care nurse blinded for randomization at 2 and 12 weeks postoperatively (primary endpoint). Healing was defined as one or no closing defects of <= 5 mm and with no undermining.ResultsAlthough we had wanted to recruit 200 patients, the study was terminated at 118 patients (NPWT group, n = 60; control group, n = 58) after interim analysis. Patients were comparable by age, sex, body mass index, previous smoking status and indication for BCL surgery. At 2 weeks 12% of patients were healed in both the NPWT and control groups [risk difference = 0.00(95% CI -0.12 to 0.11), p = 1.00]. After 12 weeks, 68% of patients were healed in the NPWT group and 72% in the control group [risk difference = -0.03 (95% CI 0.19 to 0.13), p = 0.82]. There was no significant difference in pain experienced postsurgery. In a symptom-based questionnaire, the control group reported self-esteem to be less affected (p = 0.015).ConclusionClosed-incision negative-pressure wound therapy did not significantly improve healing after BCL surgery for complicated pilonidal sinus disease.
C1 [Faurschou, Ida Kaad; Erichsen, Rune; Haas, Susanne] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Faurschou, Ida Kaad; Sorensen, Marlene Julia; Rasmussen, Simon Ladefoged; Erichsen, Rune; Haas, Susanne] Randers Reg Hosp, Pilonidal Dis Ctr, Dept Surg, Skovlyvej 17,Indgang F F1, DK-8930 Randers, Denmark.
   [Pedersen, Allan Gorm] Horsens Reg Hosp, Dept Surg, Horsens, Denmark.
   [Erichsen, Rune] Aarhus Univ, Dept Clin Epidemiol, Aarhus, Denmark.
   [Erichsen, Rune] Aarhus Univ Hosp, Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University; Aarhus
   University
RP Faurschou, IK (通讯作者)，Randers Reg Hosp, Pilonidal Dis Ctr, Dept Surg, Skovlyvej 17,Indgang F F1, DK-8930 Randers, Denmark.
EM idafau@rm.dk
OI Erichsen, Rune/0000-0001-9398-9185; Rasmussen, Simon
   Ladefoged/0000-0002-2560-4877; Faurschou, Ida Kaad/0000-0001-9760-5345
FU Pilonidal Disease Center at Randers Regional Hospital, Denmark
FX This study was initiated by the Pilonidal Disease Center at Randers
   Regional Hospital, Denmark. The authors of the study did not receive
   payment; however, the Prevena (TM) NPWT systems were sponsored by the
   producer of the products, Acility.
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NR 23
TC 3
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2025
VL 27
IS 1
AR e17198
DI 10.1111/codi.17198
EA OCT 2024
PG 8
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA S2E0Z
UT WOS:001326639900001
PM 39370557
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Boland, PA
   Kelly, ME
   Donlon, NE
   Bolger, JC
   Mehigan, BJ
   McCormick, PH
   Larkin, JO
AF Boland, Patrick Anthony
   Kelly, Michael E.
   Donlon, Noel E.
   Bolger, Jarlath C.
   Mehigan, Brian J.
   McCormick, Paul H.
   Larkin, John O.
TI Prophylactic negative pressure wound therapy for closed laparotomy
   wounds: a systematic review and meta-analysis of randomised controlled
   trials
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE Laparotomy; Negative pressure wound therapy; Surgical site infection;
   Wound care
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   PREVENTION; MANAGEMENT; GUIDELINE
AB Surgical site infections are a common source of post-operative morbidity and contribute significantly to healthcare costs. Patients undergoing emergency laparotomy and/or bowel surgery are particularly at risk. Prophylactic negative pressure wound therapy (NPWT) has been shown to reduce wound infection. However, to date, there has been a lack of consensus around its use for closed laparotomy wounds. We conducted a systematic review of randomised controlled trials comparing the use of prophylactic negative pressure wound therapy with standard dressings for closed laparotomy incisions. The primary outcome was incidence of incisional surgical site infection (SSI) at 30 days post-operatively. Secondary outcomes included superficial and deep SSI, skin dehiscence, fascial dehiscence and length of stay. A total of 2182 publications were identified, of which, following review of titles, abstracts and full texts, five studies met the criteria for inclusion. Across these studies, 467 patients were randomised to NPWT and 464 to standard dressings. Overall SSI rate was 18.6% (n = 87/467) versus 23.9% (n = 111/464) in the NPWT and standard dressing groups, respectively (Odds ratio 0.71, 95% CI 0.52-0.99,p = 0.04*). Deep SSI incidence was the same in both groups (2.6%). Both skin dehiscence and fascial dehiscence were slightly higher in the standard dressing group ((4.2%,n = 11/263 versus 3.1% (n = 8/261) and (0.9% (n = 3/324) versus 0.6% (n = 2/323)), respectively. This study observed that NPWT reduces the overall SSI for closed laparotomy wounds. It supports data recommending the use of prophylactic NPWT dressings, especially in high-risk patients in both emergency and elective circumstances.
C1 [Boland, Patrick Anthony; Kelly, Michael E.; Donlon, Noel E.; Bolger, Jarlath C.; Mehigan, Brian J.; McCormick, Paul H.; Larkin, John O.] St James Hosp, Dept Colorectal Surg, Dublin 8, Ireland.
C3 Trinity College Dublin
RP Boland, PA (通讯作者)，St James Hosp, Dept Colorectal Surg, Dublin 8, Ireland.
EM patrick.boland.1@ucdconnect.ie
RI Kelly, Michael E/AAF-1917-2021; Bolger, Jarlath/ABE-7206-2021
OI Kelly, Michael E/0000-0002-0757-6411; Boland,
   Patrick/0000-0002-5844-7695
CR [Anonymous], 2019, EXCELLENCE NIFHA PIC
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NR 48
TC 39
Z9 43
U1 0
U2 6
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
EI 1863-4362
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD FEB
PY 2021
VL 190
IS 1
BP 261
EP 267
DI 10.1007/s11845-020-02283-7
EA JUN 2020
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QA4RL
UT WOS:000543293200002
PM 32588378
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Hansson, J
   Hlebowicz, J
AF Lindstedt, Sandra
   Hansson, Johan
   Hlebowicz, Joanna
TI Comparative study of the microvascular blood flow in the intestinal wall
   during conventional negative pressure wound therapy and negative
   pressure wound therapy using paraffin gauze over the intestines in
   laparostomy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Intestinal wall; Laparostomy; Microvascular blood flow; Negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME
AB Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other kinds of wound management. We have recently shown that NPWT decreases the blood flow in the intestinal wall, and that the blood flow could be restored by inserting a protective disc over the intestines. The aim of the present study was to investigate whether layers of Jelonet (TM) (Smith & Nephew) dressing (paraffin tulle gras dressing made from open weave gauze) over the intestines could protect the intestines from hypoperfusion. Midline incisions were made in ten pigs and were subjected to treatment with NPWT with and without four layers of Jelonet over the intestines. The microvascular blood flow was measured in the intestinal wall before and after the application of topical negative pressures of -50, -70 and -120 mmHg, using laser Doppler velocimetry. Baseline blood flow was defined as 100% in all settings. The blood flow was significantly reduced, to 61 +/- 7% (P < 0.001), after the application of -50 mmHg using conventional NPWT, and to 62 +/- 7% (P < 0.001) after the application of -50 mmHg with Jelonet dressings between the dressing and the intestines. The blood flow was significantly reduced, to 38 +/- 5% (P < 0.001), after the application of -70 mmHg, and to 42 +/- 6% (P < 0.001) after the application of -70 mmHg with Jelonet dressings. The blood flow was significantly reduced, to 34 +/- 9% (P < 0.001), after the application of -120 mmHg, and to 38 +/- 6% (P < 0.001) after the application of -120 mmHg with Jelonet dressings. The use of four layers of Jelonet over the intestines during NPWT did not prevent a decrease in microvascular blood flow in the intestinal wall.
C1 [Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Hlebowicz, Joanna] Skane Univ Hosp, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Dept Surg Sci, Fac Med, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Uppsala
   University; Lund University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
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NR 22
TC 12
Z9 13
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2012
VL 9
IS 2
BP 150
EP 155
DI 10.1111/j.1742-481X.2011.00871.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 904WZ
UT WOS:000301230900008
PM 21985421
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Faisal, M
   Berend, PD
   Seemann, R
   Janik, S
   Grasl, S
   Ritzengruber, A
   Mendel, H
   Jamshed, A
   Hussain, R
   Erovic, BM
AF Faisal, Muhammad
   Berend, Peter D.
   Seemann, Rudolf
   Janik, Stefan
   Grasl, Stefan
   Ritzengruber, Andrea
   Mendel, Herbert
   Jamshed, Arif
   Hussain, Raza
   Erovic, Boban M.
TI Impact of Previous Irradiation on Wound Healing after Negative Pressure
   Wound Therapy in Head and Neck Cancer Patients-A Systematic Review
SO CANCERS
LA English
DT Review
DE negative pressure wound therapy; head and neck cancers; radiation
   therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Simple Summary
   The study has focused on the use of Negative Pressure Wound Therapy (NPWT) specifically in head and neck cancer patients. The sole purpose of using NPWT is to expedite the process of healing as most of the head and neck cancer patients are bound to get post-operative radiotherapy and any delay would further lengthen the treatment and affect the outcome. Previous irradiation and Diabetes Mellitus have detrimental impact on wound healing after NPWT.
   (1) Background: Negative pressure wound therapy (NPWT) has been effectively used for wound management in comparison to traditional dressings. The purpose of this study was to provide an evidence-based review of NPWT in head and neck cancer patients, as well as the impact of previous irradiation and other risk factors on wound healing. (2) Material and Methods: We conducted a comprehensive search in PubMed, Medline, Embase, Web of Science, and Cochrane Library databases for relevant literature. (3) Results: 15 studies fulfilled the inclusion criteria. The most common etiologies requiring NPWT were defects post tumor resection and flap reconstruction and oro/pharyngo-cutaneous fistulas. The neck was found to be the most common site of involvement (47.3%). The overall wound healing response rate was 87.5%. The median negative pressure recorded was 125 mm of Hg, with a median dressing change time of three days. Previous irradiation (p = 0.01; OR = 4.07) and diabetes mellitus (DM) (p = 0.001; OR = 5.62) were found to be significantly associated with delayed wound healing after NPWT. (4) Conclusion: NPWT treats complex wounds in head and neck cancer patients and should represent a significant armamentarium in head and neck cancers. Previous irradiation and DM have detrimental effects on wound healing after NPWT.
C1 [Faisal, Muhammad; Seemann, Rudolf; Erovic, Boban M.] Evangel Hosp, Inst Head & Neck Dis, A-1180 Vienna, Austria.
   [Faisal, Muhammad; Jamshed, Arif; Hussain, Raza] Shaukat Khanum Mem Canc Hosp, Dept Head & Neck Surg, Lahore 54000, Pakistan.
   [Berend, Peter D.; Janik, Stefan; Grasl, Stefan] Med Univ Vienna, Dept Otolaryngol Head & Neck Surg, A-1090 Vienna, Austria.
   [Ritzengruber, Andrea] Evangelical Hosp, Wound Management, A-1180 Vienna, Austria.
   [Mendel, Herbert] Evangelical Hosp, Dept Gen Surg, A-1180 Vienna, Austria.
C3 Evangelisches Krankenhaus Vienna; Shaukat Khanum Memorial Cancer
   Hospital & Research Centre; Medical University of Vienna
RP Erovic, BM (通讯作者)，Evangel Hosp, Inst Head & Neck Dis, A-1180 Vienna, Austria.
EM maxfas@live.com; pdberend@gmail.com; rudolf.seemann@gmail.com;
   stefan.janik@meduniwien.ac.at; stefan.grasl@meduniwien.ac.at;
   a.ritzengruber@gmail.com; herbert.mendel@gmx.at; jamshedarif@gmail.com;
   razah@skm.org.pk; b.erovic@ekhwien.at
RI Erovic, Boban/S-7824-2018; Faisal, Muhammad/AAM-6214-2020
OI Erovic, Boban/0000-0001-5706-1056; Faisal, Muhammad/0000-0001-6564-0410;
   Janik, Stefan/0000-0002-1161-4871
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   National Heart Lung and Blood Institute, National Institute of Health Quality Assessment Tool
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NR 43
TC 12
Z9 14
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAY
PY 2021
VL 13
IS 10
AR 2482
DI 10.3390/cancers13102482
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SI2SZ
UT WOS:000654677600001
PM 34069610
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sun, XF
   Wu, SH
   Xie, T
   Zhang, JP
AF Sun, Xiaofang
   Wu, Shaohan
   Xie, Ting
   Zhang, Jianping
TI Combing a novel device and negative pressure wound therapy for managing
   the wound around a colostomy in the open abdomen: A case report
SO MEDICINE
LA English
DT Article
DE a novel device; colostomy; negative pressure wound therapy; open
   abdomen; ostomy
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL CLOSURE; MANAGEMENT; METAANALYSIS;
   PERITONITIS; MORTALITY; FISTULA
AB Rationale:An open abdomen complicated with small-bowel fistulae becomes a complex wound for local infection, systemic sepsis and persistent soiling irritation by intestinal content. While controlling the fistulae drainage, protecting surrounding skin, healing the wound maybe a challenge.Patient concerns:In this paper we described a 68-year-old female was admitted to emergency surgery in general surgery department with severe abdomen pain. Resection part of the injured small bowel, drainage of the intra-abdominal abscess, and fashioning of a colostomy were performed.Diagnoses:She failed to improve and ultimately there was tenderness and lot of pus under the skin around the fistulae. The wound started as a 3-cm(2) lesion and progressed to a 6x13 (78cm(2)) around the stoma.Interventions:In our case we present a novel device for managing colostomy wound combination with negative pressure wound therapy.Outcomes:This tube allows for an effective drainage of small-bowel secretion and a safe build-up of granulation tissue. Also it could be a barrier between the bowel suction point and foam.Lessons:Management of open abdomen wound involves initial dressing changes, antibiotic use and cutaneous closure. When compared with traditional dressing changes, the NPWT offers several advantages including increased granulation tissue formation, reduction in bacterial colonization, decreased of bowel edema and wound size, and enhanced neovascularization.
C1 [Sun, Xiaofang; Zhang, Jianping] Jiaxing Univ, Hosp 2, Dept Dermatol, 1518 Huancheng North Rd, Jiaxing 314000, Zhejiang, Peoples R China.
   [Wu, Shaohan] Jiaxing Univ, Hosp 2, Dept Gen Surg, Jiaxing, Zhejiang, Peoples R China.
   [Xie, Ting] Shanghai Jiao Tong Univ, Sch Med, Wound Healing Dept, Shanghai Peoples Hosp 9, Shanghai, Peoples R China.
C3 Jiaxing University; Jiaxing University; Shanghai Jiao Tong University
RP Zhang, JP (通讯作者)，Jiaxing Univ, Hosp 2, Dept Dermatol, 1518 Huancheng North Rd, Jiaxing 314000, Zhejiang, Peoples R China.
EM doctorjpzhang@163.com
FU National Natural Science Foundation of China [81671917]; Science and
   Technology Program of Jiaxing [2017AY33037]
FX This study was supported by grants from the National Natural Science
   Foundation of China (81671917), the Science and Technology Program of
   Jiaxing (2017AY33037).
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   Cristaudo A, 2017, AM SURGEON, V83, P191
   Di Saverio S, 2016, LANGENBECK ARCH SURG, V401, P1, DOI 10.1007/s00423-015-1370-3
   Durmishi Y, 2007, J CHIR-PARIS, V144, P209, DOI 10.1016/S0021-7697(07)89516-0
   Fischer JE, 2008, AM J SURG, V196, P1, DOI 10.1016/j.amjsurg.2008.01.001
   Heller L, 2006, AM J SURG, V191, P165, DOI 10.1016/j.amjsurg.2005.09.003
   Losanoff JE, 2003, AM J SURG, V185, P394, DOI 10.1016/S0002-9610(02)01428-9
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   Salman AE, 2014, HERNIA, V18, P99, DOI 10.1007/s10029-012-1008-0
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   Trevelyan S L, 2009, J Wound Care, V18, P24
NR 15
TC 7
Z9 10
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2017
VL 96
IS 52
AR e9370
DI 10.1097/MD.0000000000009370
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW5VC
UT WOS:000425386300021
PM 29384913
DA 2026-07-24
ER

PT J
AU Joethy, J
   Sebastin, SJ
   Chong, AKS
   Peng, YP
   Puhaindran, ME
AF Joethy, Janna
   Sebastin, Sandeep J.
   Chong, Alphonsus Khin Sze
   Peng, Yeong Pin
   Puhaindran, Mark E.
TI Effect of negative-pressure wound therapy on open fractures of the lower
   limb
SO SINGAPORE MEDICAL JOURNAL
LA English
DT Article
DE free flap; negative-pressure wound therapy; occlusive dressing; open
   tibial fractures; vacuum-aided closure
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY; DEEP INFECTION; TIME-DELAY;
   FREE FLAPS; MANAGEMENT; RECONSTRUCTION; TRAUMA
AB INTRODUCTION Early debridement and coverage has long been regarded as the standard of care for open fractures of the lower limb, as infection is a serious complication. However, the best time for wound closure remains controversial. Negative-pressure wound therapy (NPWT) is thought to result in reduced flap infection and failure. To determine the effect of NPWT, we reviewed patients with open fractures of the lower limb and compared the rates of infection and flap failure in two time-based cohorts.
   METHODS Two cohorts of patients (periods 2003-2004 and 2008-2009) with Gustilo type IIIB open tibial fractures were recruited and their outcomes were compared. In the 2003-2004 cohort, wounds were dressed with occlusive dressing. In the 2008-2009 cohort, all patients underwent NPWT. Data was retrospectively analysed with regard to infection, failure, age, type of flap, comorbidities and defect size. The incidences of infection and flap failure were further analysed for any statistical difference between the different treatment protocols.
   RESULTS In the 2003-2004 cohort, 33% of patients developed infection and 11% had flap failure. However, in the 2008-2009 cohort, 10% of patients developed infection and 6% had flap failure. The difference in the incidence of infection was statistically significant between the two cohorts (p = 0.029).
   CONCLUSION Patients in the 2008-2009 cohort had better outcomes, and we are of the opinion that performing NPWT may have contributed to this result.
C1 [Joethy, Janna] Natl Univ Hlth Syst, Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 119228, Singapore.
   [Sebastin, Sandeep J.; Chong, Alphonsus Khin Sze; Peng, Yeong Pin; Puhaindran, Mark E.] Natl Univ Hlth Syst, Dept Hand & Reconstruct Microsurg, Singapore 119228, Singapore.
C3 National University of Singapore; Singapore General Hospital; National
   University of Singapore
RP Puhaindran, ME (通讯作者)，Natl Univ Hlth Syst, Dept Hand & Reconstruct Microsurg, 1E Kent Ridge Rd,NUHS Tower Block,Level 11, Singapore 119228, Singapore.
EM Mark_E_Puhaindran@nuhs.edu.sg
RI ; /E-7820-2010; Chong, Alphonsus/AGT-2992-2022
OI Chong, Alphonsus/0000-0001-6224-5482; 
CR Ashford RU, 2004, INJURY, V35, P411, DOI 10.1016/S0020-1383(03)00236-5
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nanchahal J., 2009, Standards for the Management of Open Fractures of the Lower Limb
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Peterson AS., 2010, The Journal of Lancaster General Hospital, V5, P134
   Pollak Andrew N, 2006, J Am Acad Orthop Surg, V14, pS48
   Pollak AN, 2010, J BONE JOINT SURG AM, V92A, P7, DOI 10.2106/JBJS.H.00984
   Spencer J, 2004, ANN ROY COLL SURG, V86, P108, DOI 10.1308/003588404322827491
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   YAREMCHUK MJ, 1987, PLAST RECONSTR SURG, V80, P1
NR 19
TC 16
Z9 20
U1 0
U2 5
PU SINGAPORE MEDICAL ASSOC
PI SINGAPORE
PA 2985 JALAN BUKIT MERAH, #02-2C, SMF BUILDING, SINGAPORE, SINGAPORE
SN 0037-5675
J9 SINGAP MED J
JI Singap. Med. J.
PD NOV
PY 2013
VL 54
IS 11
BP 620
EP 623
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 270LY
UT WOS:000328321100012
PM 24276097
DA 2026-07-24
ER

PT J
AU Li, JQ
   Topaz, M
   Tan, H
   Li, YJ
   Li, WZ
   Xun, WX
   Yuan, YQ
   Chen, SZ
   Li, XY
AF Li, Jinqing
   Topaz, Morris
   Tan, Hong
   Li, Yuejun
   Li, Wangzhou
   Xun, Wenxing
   Yuan, Yanqin
   Chen, Shaozong
   Li, Xueyong
TI Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated
   Negative Pressure Wound Therapy
SO ANNALS OF SURGERY
LA English
DT Article
DE blast injury; infection; regulated negative pressure wound therapy;
   wound healing
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; MULTICENTER
AB Objective: This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected blast injuries in swine.
   Background: Approximately 30% to 80% of blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries.
   Methods: Infected soft tissue blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the blast injury, the bacterial load, bacterial species, and several inflammatory markers were detected.
   Results: Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue blast injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group.
   Conclusions: RNPT clearly shows beneficial effects in treating the infected soft tissue blast injury in comparison with the gauze dressing therapy in swine.
C1 [Li, Jinqing; Li, Yuejun; Li, Wangzhou; Xun, Wenxing; Yuan, Yanqin; Chen, Shaozong; Li, Xueyong] Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burn Surg, Xian 710038, Peoples R China.
   [Topaz, Morris] Hillel Yaffe Med Ctr, Plast Surg Unit, Hadera, Israel.
   [Tan, Hong] Univ Colorado, Cell & Dev Biol Dept, Aurora, CO USA.
C3 Air Force Medical University; University of Colorado System; University
   of Colorado Anschutz
RP Li, XY (通讯作者)，Fourth Mil Med Univ, Tangdu Hosp, Dept Plast & Burns, Xian 710038, Peoples R China.
EM yuy-ong@fmmu.edu.cn
RI Li, Jinqing/A-2334-2013
OI Li, Jinqing/0000-0003-4635-2661; Tan, Hong/0000-0002-8660-8222
FU National Natural Science grants [81071570, 30872679]
FX Supported by National Natural Science grants (81071570 and 30872679).
   The authors declare that they have nothing to disclose.
CR [Anonymous], 105 GEN M AM SOC MIC
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NR 32
TC 27
Z9 31
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2013
VL 257
IS 2
BP 335
EP 344
DI 10.1097/SLA.0b013e318269d1ca
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 068IX
UT WOS:000313361300024
PM 23108116
DA 2026-07-24
ER

PT J
AU Sjögren, J
   Gustafsson, R
   Nilsson, J
   Lindstedt, S
   Nozohoor, S
   Ingemansson, R
AF Sjogren, Johan
   Gustafsson, Ronny
   Nilsson, Johan
   Lindstedt, Sandra
   Nozohoor, Shahab
   Ingemansson, Richard
TI Negative-pressure wound therapy following cardiac surgery: bleeding
   complications and 30-day mortality in 176 patients with deep sternal
   wound infection
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Wound infection; Sternum; Negative-pressure wound therapy; Outcome
ID RIGHT-VENTRICULAR RUPTURE; VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; CONVENTIONAL TREATMENT
AB Negative-pressure wound therapy (NPWT) has been used for the treatment of deep sternal wound infection (DSWI) with promising results. However, questions have been raised regarding the potential risk of right ventricle (RV) rupture during treatment. In the present study, we evaluate our clinical experience of NPWT focusing on RV rupture and major bleeding complications and its potentially negative impact on 30-day mortality during an 11-year period. Serious bleeding complications during NPWT were reviewed for 176 patients treated for DSWI between January 1999 and April 2010. The 30-day mortality following DSWI was 1.1% (2/176). Four patients (2.3%) suffered bleeding from the RV rupture during NPWT of the sternal wound (two spontaneous and two debridement related). Furthermore, two patients had debridement-related bleedings from the venous bypass grafts during wound dressing change. The very low 30-day mortality (1.1%) following DSWI supports the use of NPWT. Overall, even if major bleeding complications may occur, the risk of RV rupture seems to be outweighed by the benefit of superior infection control. However, surgical experience is recommended when debriding sternal wounds and we recommend the use of a wound dressing, such as paraffin gauze, in order to protect the RV from direct contact with the polyurethane foam. (C) 2011 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
C1 [Sjogren, Johan; Gustafsson, Ronny; Nilsson, Johan; Lindstedt, Sandra; Nozohoor, Shahab; Ingemansson, Richard] Lund Univ, Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital
RP Sjögren, J (通讯作者)，Lund Univ, Univ Lund Hosp, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM johan.sjogren@med.lu.se
RI Nilsson, Johan/A-4742-2011; Lindstedt, Sandra/AEM-2892-2022; Sjögren,
   Johan/AAZ-6448-2021
OI Nilsson, Johan/0000-0001-6860-6090; Lindstedt,
   Sandra/0000-0003-4484-6473; Ingemansson, Richard/0000-0001-7623-8953; 
CR Abu-Omar Y, 2003, ANN THORAC SURG, V76, P974, DOI 10.1016/S0003-4975(03)00180-2
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   Ennker IC, 2009, J CARDIOTHORAC SURG, V4, DOI 10.1186/1749-8090-4-5
   Erwin F, 2010, INTERACT CARDIOV TH, V10, P472
   Gårdlund B, 2002, EUR J CARDIO-THORAC, V21, P825, DOI 10.1016/S1010-7940(02)00084-2
   Khoynezhad A, 2004, J CARDIAC SURG, V19, P74, DOI 10.1111/j.0886-0440.2004.04015.x
   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Niclauss L, 2010, INTERACT CARDIOV TH, V10, P470, DOI 10.1510/icvts.2009.223891
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   Sartipy U, 2006, ANN THORAC SURG, V82, P1110, DOI 10.1016/j.athoracsur.2006.01.060
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Yellin A, 2003, J THORAC CARDIOV SUR, V125, P554, DOI 10.1067/mtc.2003.31
NR 15
TC 45
Z9 51
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD FEB
PY 2011
VL 12
IS 2
BP 117
EP 120
DI 10.1510/icvts.2010.252668
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 022BR
UT WOS:000309930500006
PM 21106567
OA Bronze
DA 2026-07-24
ER

PT J
AU Wang, Z
   Bai, M
   Zeng, A
   Liu, ZF
   Zhao, R
   Wang, XJ
AF Wang, Zhi
   Bai, Ming
   Zeng, Ang
   Liu, Zhifei
   Zhao, Ru
   Wang, Xiaojun
TI The Role of Negative Pressure Wound Therapy in Managing Chinese Patients
   With Wound derived Acute Severe Illness
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE emergency service; hospital; negative pressure wound therapy; salvage
   therapy; shock; septic; wound healing; acute
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; INJURY
AB Introduction. Resulting mostly from major injury or infection, severe acute wounds are often accompanied by septic shock or multiple organ failure and associated with high disability and mortality rates. In managing Chinese patients with wound-derived acute severe illnesses, salvage treatment in the emergency department has traditionally prioritized life support and protection of vital organs before wound repair. Objective. This retrospective review evaluated the outcomes of patients with wound-derived acute severe illness who were treated with a new salvage protocol that combined proactive wound care with simultaneous life-support measures. Materials and Methods. Records from 2011 to 2013 at Peking Union Medical College Hospital (PUMCH) in Beijing, China, were reviewed to identify patients with wound-derived acute severe illness treated with the new protocol. The plastic surgery department, emergency department, and intensive care unit developed the protocol, which included proactive wound treatment with negative pressure wound therapy (NPWT), interdepartmental cooperation, and comprehensive patient treatment. Results. Fifty-six patients were managed with the new protocol. At presentation, all patients were in septic shock and 29 of 56 (51.8%) required mechanical ventilation. Of the treated patients, 21 (37.5%) fully recovered and 29 (51.8%) improved sufficiently enough for transfer to a general ward. Six patients (10.7%) died of causes unrelated to NPWT. Conclusions. At PUMCH, the new collaborative salvage protocol with proactive use of NPWT with simultaneous life-support methods resulted in greater therapeutic effects than traditional salvage treatment could offer.
C1 [Wang, Zhi; Bai, Ming; Zeng, Ang; Liu, Zhifei; Zhao, Ru; Wang, Xiaojun] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital
RP Wang, XJ (通讯作者)，Peking Union Med Coll Hosp East, 1 Shuaifuyuan Wangfujing, Beijing 100730, Peoples R China.
EM pumchwxj@163.com
RI 龙, 笑/GPW-6382-2022; /AAT-4908-2020; wang, xiaojun/NFT-0476-2025
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Morykwas MJ, 2002, J TRAUMA, V53, P537, DOI 10.1097/00005373-200209000-00023
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Singer M, 2016, JAMA-J AM MED ASSOC, V315, P801, DOI 10.1001/jama.2016.0287
   Torbrand C, 2010, J CARDIOTHORAC SURG, V5, DOI 10.1186/1749-8090-5-75
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NR 14
TC 1
Z9 2
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2018
VL 30
IS 8
BP 235
EP 241
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GQ7IH
UT WOS:000441910800008
PM 30212366
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Ingemansson, R
   Malmsjo, M
AF Lindstedt, Sandra
   Ingemansson, Richard
   Malmsjo, Malin
TI Haemodynamic effects of negative pressure wound therapy when using a
   rigid barrier to prevent heart rupture
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Animal model; Experimental surgery; Haemodynamics; Negative pressure
   wound therapy; Sternotomy wound
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   INFECTION; EXPERIENCE; ALGORITHM
AB Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up and damaged by the sharp sternum bone edges. The aim of this study was to investigate the haemodynamic effects of placing a rigid barrier over the heart to protect it from rupture during NPWT. Eight pigs underwent median sternotomy followed by NPWT at -70 and -120 mmHg, using foam, with or without a rigid plastic disc between the heart and the sternal edges. The heart frequency, cardiac output, mean systemic arterial pressure, mean pulmonary artery pressure, central venous pressure and left atrial pressure were recorded. Cardiac output was not affected by NPWT, regardless of whether a rigid barrier was used. Heart frequency decreased during NPWT without a disc, and showed a tendency towards a decrease when using a rigid disc. The blood pressure decreased during NPWT without a disc, and showed only a tendency towards a decrease when a disc was inserted between the heart and the sternum. In conclusion, the results of this haemodynamic study show that a rigid disc can safely be placed over the heart during NPWT, to prevent heart rupture. The haemodynamic effects of NPWT in sternotomy wounds are slightly reduced by the presence of the rigid disc.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
   [Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, SE-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473;
   Ingemansson, Richard/0000-0001-7623-8953
CR Conquest AM, 2003, J SURG RES, V115, P209, DOI 10.1016/S0022-4804(03)00331-7
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   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjogren Johan, 2004, Interact Cardiovasc Thorac Surg, V3, P666, DOI 10.1016/j.icvts.2004.08.003
   Steigelman MB, 2009, ANN THORAC SURG, V88, P1277, DOI 10.1016/j.athoracsur.2009.06.027
NR 22
TC 5
Z9 5
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 385
EP 392
DI 10.1111/j.1742-481X.2011.00803.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600009
PM 21585658
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Gabriel, A
   Thimmappa, B
   Rubano, C
   Storm-Dickerson, T
AF Gabriel, Allen
   Thimmappa, Brinda
   Rubano, Christopher
   Storm-Dickerson, Toni
TI Evaluation of an ultra-lightweight, single-patient-use negative pressure
   wound therapy system over dermal regeneration template and skin grafts
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Dermal regeneration template; Skin graft; Ultra-lightweight negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CONTROLLED-TRIAL;
   RECONSTRUCTION; INTEGRA; DEVICE; FOOT
AB As the use of negative pressure wound therapy (NPWT) over skin grafts has increased, traditional methods of NPWT system reimbursement and application are increasingly being challenged. A simplified method of accessing and operating NPWT in the outpatient setting is needed, particularly in cases where immediate outpatient use of NPWT is optimal. We evaluated use of a new ultra-lightweight, off-the-shelf, disposable, single-patient-use NPWT system (SP-NPWT; V.A.C.Via Therapy, KCI USA, Inc., San Antonio, TX) over dermal regeneration template (DRT) and/or skin grafts. SP-NPWT was initiated over a DRT and/or skin graft in 33 patients with 41 graft procedures. Endpoints were recorded and compared to a historical control group of 25 patients with 28 grafts bolstered with traditional rental NPWT (V.A.C.(R) Therapy, KCI USA, Inc.). Average length of inpatient hospital stay was 0 center dot 0 days for the SP-NPWT group and 6 center dot 0 days for the control group (P < 0 center dot 0001). The average duration of SP-NPWT post-DRT or skin graft was 5 center dot 6 days for the SP-NPWT group and 7 center dot 0 days for the control (P < 0 center dot 0001). Preliminary data suggest that, compared to traditional NPWT, off-the-shelf SP-NPWT may provide a quicker, seamless transition to home, resulting in decreased hospital stay and potential cost savings.
C1 [Gabriel, Allen; Thimmappa, Brinda; Rubano, Christopher; Storm-Dickerson, Toni] Southwest Washington Med Ctr, Dept Surg, Vancouver, WA 98664 USA.
RP Gabriel, A (通讯作者)，Southwest Washington Med Ctr, Dept Surg, 505 NE 87th Ave Bldg A Suite 250, Vancouver, WA 98664 USA.
EM gabrielallen@yahoo.com
RI Gabriel, Allen/AFK-3548-2022
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NR 16
TC 8
Z9 8
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2013
VL 10
IS 4
BP 418
EP 424
DI 10.1111/j.1742-481X.2012.00999.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 187YM
UT WOS:000322157600012
PM 22682307
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Vallejo-Carmona, L
AF Vallejo-Carmona, Leticia
TI Structure-guided negative pressure wound therapy (NPWT) : personalised
   tissue biomodulation with an NPWT system in adults and older adults
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Negative pressure wound therapy; near-infrared spectroscopy; wound
   healing; perfusion; tissue oxygenation; biomodulation
ID VACUUM-ASSISTED CLOSURE; SILVER; RECOMMENDATIONS; MULTICENTER
AB Background: Negative pressure wound therapy(NPWT) has revolutionised the management of complex wounds via mechanisms such as microdeformation, angiogenesis and exudate control. However, its clinical effect has historically only been evaluated by qualitative and visual parameters. This study integrates near-infrared spectroscopy (NIRS) as a biofeedback tool to quantify physiological response to NPWT in real time. Objective: This study aimed to quantitatively demonstrate the physiological and structural changes induced by an NPWT system in patients with complex wounds, measured using NIRS. Methods: A prospective real-world observational study was conducted with a cohort of 23 patients with 33 wounds. Structural and physiological parameters were documented before and after NPWT treatment. Random-intercept mixed-effect statistical models and pre-post comparison tests were used to assess clinical and physiological significance. Results: The data showed a progressive reduction in wound area and volume, accompanied by an increase in tissue oxygen saturation and a sustained decrease in deoxygenated haemoglobin. These findings, objectively quantified through NIRS as a real-time biofeedback tool, highlight the improvement in oxygenation and wound-bed perfusion and support the hypothesis of tissue biomodulation induced by NPWT. Conclusion: The integration of NIRS redefines the clinical role of NPWT, allowing therapy to be customised based on specific physiological data. This combination represents a new frontier in precision wound medicine. The results of this study provide a foundation for a new generation of clinical decisions in advanced wound management.
C1 [Vallejo-Carmona, Leticia] Puerto Rico Wound Healing Soc, Wound Care Plus Educ & Res Ctr, Orlando, FL 32801 USA.
   [Vallejo-Carmona, Leticia] Wound & Ulcer Ctr Florida, Wound & Ulcer Care Clin San Juan, Orlando, FL 32801 USA.
   [Vallejo-Carmona, Leticia] Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00928 USA.
C3 Universidad Ana G. Mendez
RP Vallejo-Carmona, L (通讯作者)，Puerto Rico Wound Healing Soc, Wound Care Plus Educ & Res Ctr, Orlando, FL 32801 USA.; Vallejo-Carmona, L (通讯作者)，Wound & Ulcer Ctr Florida, Wound & Ulcer Care Clin San Juan, Orlando, FL 32801 USA.; Vallejo-Carmona, L (通讯作者)，Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00928 USA.
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2025
VL 34
IS 11
SU B
PG 24
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9WK2C
UT WOS:001616629000001
DA 2026-07-24
ER

PT J
AU Rentea, RM
   Somers, KK
   Cassidy, L
   Enters, J
   Arca, MJ
AF Rentea, Rebecca M.
   Somers, Kimberly K.
   Cassidy, Laura
   Enters, Jessica
   Arca, Marjorie J.
TI Negative pressure wound therapy in infants and children: a
   single-institution experience
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Wound healing; Neonatal; Infants; Abdominal wounds; Negative pressure
   wound therapy; Surgery
ID VACUUM-ASSISTED CLOSURE; PEDIATRIC-PATIENTS; MANAGEMENT; GASTROSCHISIS;
   MEDIASTINITIS; FRACTURES; INFECTION; INJURIES; SURGERY; SKIN
AB Background: Information regarding the use of negative pressure wound therapy (NPWT) in the pediatric population is limited. Because of adverse outcomes in adult patients, the Food and Drug Administration issued a warning in 2011 about the use of NPWT in infants and children.
   Methods: We performed an institutional review board-approved, single-institution, retrospective review of pediatric patients who had undergone NPWT from 2007-2011. We collected the types of wounds for which NPWT was initiated, the NPWT outcomes, and the complications encountered.
   Results: The data from 290 consecutive patients were reviewed. Their average age was 9.3 y (range 12 d to 18 y), and their average weight was 46.5 kg (range 1.1-177). Of the wounds, 66% were classified as acute, 10% as chronic, and 24% as traumatic. The two most common indications were surgical wound dehiscence (n = 47) and skin grafting (n = 41). NPWT was used in 15 wounds containing surgical hardware, with 2 devices requiring eventual removal. NPWT was used for a median of 9 d per patient (two dressing changes). Complications occurred in 5 patients (1.7%). Documentation problems were noted in 44 patients. After NPWT, about one-third of the patients (n = 95 patients) were able to undergo delayed primary closure.
   Conclusions: NPWT is an effective adjunct in wound healing and closure in the pediatric population, with no mortality ascribed to NPWT. Also, the complication rates were low. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Rentea, Rebecca M.] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA.
   [Somers, Kimberly K.; Cassidy, Laura; Enters, Jessica; Arca, Marjorie J.] Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Surg, Div Pediat Surg, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin; Children's
   Hospital of Wisconsin
RP Arca, MJ (通讯作者)，Med Coll Wisconsin, Childrens Hosp Wisconsin, Dept Surg, Div Pediat Surg, 999 North 92nd Ave,Suite 320, Milwaukee, WI 53226 USA.
EM marca@chw.org
OI Rentea, Rebecca/0000-0002-8689-5989
CR American Academy of Pediatrics, US DRUGS NOT DESCR P
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NR 27
TC 29
Z9 34
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
J9 J SURG RES
JI J. Surg. Res.
PD SEP
PY 2013
VL 184
IS 1
BP 658
EP 664
DI 10.1016/j.jss.2013.05.056
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 207NX
UT WOS:000323609400106
PM 23768766
DA 2026-07-24
ER

PT J
AU Karl, T
   Storck, M
AF Karl, T.
   Storck, M.
TI Negative pressure wound therapy. Importance within a differentiated
   treatment concept for femorodistal and inguinal vascular prosthesis
   infections
SO GEFASSCHIRURGIE
LA German
DT Article
DE Wound healing disorders in the perivascular region; Vascular surgery;
   Graft-preserving procedures; Alloplastic graft material; Negative
   pressure wound therapy (NPWT)
ID VACUUM-ASSISTED CLOSURE; GRAFT INFECTION; AUTOGENOUS RECONSTRUCTION;
   SURGICAL-MANAGEMENT; GROIN INFECTIONS; RIFAMPICIN; REPLACEMENT;
   RESISTANCE; BYPASS
AB Wound healing disorders in the perivascular region are a dangerous complication in vascular surgery. Despite many measures established in the past to prevent such infections, deep wound infections occur in up to 6% of cases. Especially if alloplastic material is used, not only the result of the arterial reconstruction but limb salvage and survival of the patient are critical due to life-threatening septic arrosion bleeding.
   Until a few years ago it was mandatory to completely explant alloplastic graft material in the case of deep infection involving the graft material, however, after the introduction of negative pressure wound therapy (NPWT) there are a growing number of reports available in the literature on successful graft-preserving procedures in cases of periprosthetic infections.
   It was the aim of this analysis of 29 own cases as well as of the literature to define a new classification of inguinal and femorodistal perivascular wound and/or graft infections, under the aspect of the availability of NPWT.
   The decision for graft preservation procedures should be based on the extent (depth) and localization of the infection, the type of bacterial infection and already existing complications. Complex stages, such as arrosion bleeding, anastomotic pseudoaneurysm and septic embolization require complete graft explantation, in less complicated cases graft-preserving procedures using NPWT can be justified.
C1 [Karl, T.] Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, D-60316 Frankfurt, Germany.
   [Storck, M.] Stadt Klinikum Karlsruhe, Klin Gefass & Thoraxchirurg, Karlsruhe, Germany.
C3 Municipal Hospital Karlsruhe
RP Karl, T (通讯作者)，Klin Rotes Kreuz, Abt Gefass & Endovasc Chirurg, Konigswarterstr 16, D-60316 Frankfurt, Germany.
EM dr.t.karl@web.de
RI /L-6893-2017
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NR 52
TC 6
Z9 7
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0948-7034
EI 1434-3932
J9 GEFASSCHIRURGIE
JI Gefasschirurgie
PD FEB
PY 2012
VL 17
IS 1
BP 37
EP 44
DI 10.1007/s00772-011-0952-9
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 893AS
UT WOS:000300328000007
DA 2026-07-24
ER

PT J
AU Lin, PY
   Liou, TL
   Lin, KC
   Hsieh, MH
   Chien, CY
   Hsieh, CH
AF Lin, Pao-Yuan
   Liou, Tz-Luen
   Lin, Ko-Chien
   Hsieh, Mu-Han
   Chien, Chih-Yen
   Hsieh, Ching-Hua
TI Immediate Negative Pressure Wound Therapy After Free Flap Transfer for
   Head and Neck Cancer Surgery
SO LARYNGOSCOPE
LA English
DT Article
DE Free flap; head and neck reconstruction; negative pressure wound
   therapy; standard care; wound infection; complication
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; RECONSTRUCTION; MULTICENTER;
   DISSECTION
AB Objective Methods This study aimed to assess the outcomes of administering negative-pressure wound therapy (NPWT) in patients immediately following free flap reconstruction after head and neck cancer surgery and radical neck lymph node dissection. The outcomes were compared with those of patients who received conventional wound care (CWC). A retrospective analysis was performed for 58 patients with head and neck cancer who underwent free flap reconstruction after tumor ablation and radical neck dissection between February 1, 2016, and October 31, 2016. All reconstructions were performed by the same plastic surgeon. Charts were reviewed for patient demographics, comorbidities, cancer type, operation time, flap type, postoperative drainage volume, complication rates, length of hospital stay, and wound outcomes. Results Conclusion No significant difference was observed between patients receiving NPWT and CWC regarding operation time and drainage volume from the vacuum ball. After the application of NPWT, no patients experienced flap failure or developed a wound infection. Significantly fewer patients receiving NPWT developed complications (9.7% vs. 37.0%; P = 0.025) and developed infections (0.0% vs. 14.8%; P = 0.041) compared with those receiving CWC. On the basis of fewer associated complications and infections, this study supports the immediate use of NPWT after free flap reconstruction in patients who have undergone head and neck cancer ablation and radical neck lymph node dissection. Level of Evidence 4. Laryngoscope, 2478-2482, 2018
C1 [Lin, Pao-Yuan; Liou, Tz-Luen; Lin, Ko-Chien; Hsieh, Mu-Han; Hsieh, Ching-Hua] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Chien, Chih-Yen] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   Coll Med, Kaohsiung, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Hsieh, CH (通讯作者)，Kaohsiung Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.; Hsieh, CH (通讯作者)，Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
EM m93chinghua@gmail.com
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NR 31
TC 17
Z9 17
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD NOV
PY 2018
VL 128
IS 11
BP 2478
EP 2482
DI 10.1002/lary.27169
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Otorhinolaryngology
GA HC2IG
UT WOS:000451624900015
PM 30247762
DA 2026-07-24
ER

PT J
AU Uchino, M
   Hirose, K
   Bando, T
   Chohno, T
   Takesue, Y
   Ikeuchi, H
AF Uchino, Motoi
   Hirose, Kei
   Bando, Toshihiro
   Chohno, Teruhiro
   Takesue, Yoshio
   Ikeuchi, Hiroki
TI Randomized Controlled Trial of Prophylactic Negative-Pressure Wound
   Therapy at Ostomy Closure for the Prevention of Delayed Wound Healing
   and Surgical Site Infection in Patients with Ulcerative Colitis
SO DIGESTIVE SURGERY
LA English
DT Article
DE Ostomy closure; Purse-string suture; Negative pressure wound therapy;
   Ulcerative colitis
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL CLOSURE; OPEN ABDOMEN; DISEASE;
   DEVICE
AB Background/Aims: Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear for digestive surgery. We performed a prospective randomized controlled study to evaluate the efficacy and safety of this procedure during ileostomy closure. Methods: We conducted a prospective, randomized study between November 2014 and September 2015. Patients with ulcerative colitis scheduled to undergo ileostomy closure with purse-string suture (PSS) were randomly divided into groups with or without NPWT. The primary endpoint was complete wound healing. The secondary endpoints were incidences of wound complications. Results: A total of 31 patients with PSS alone and 28 patients with PSS + NPWT were enrolled. Wound infection was observed in 1 patient in the PSS-alone condition and 3 patients in the PSS + NPWT condition (p = 0.76). The mean duration of complete wound healing was 37.6 +/- 11.7 days in the PSS-alone condition and 33.5 +/- 10.0 days in the PSS + NPWT condition (p = 0.18). Conclusion: Although no adverse effects were observed in this series, the efficacy of PSS + NPWT was not confirmed. Further clarification of the indication of prophylactic NPWT and its efficacy must be obtained, and the efficacy and safety of NPWT in different dirty/infected surgeries should be evaluated. (C) 2016 S. Karger AG, Basel.
C1 [Uchino, Motoi; Hirose, Kei; Bando, Toshihiro; Chohno, Teruhiro; Ikeuchi, Hiroki] Hyogo Coll Med, Dept Inflammatory Bowel Dis, Nishinomiya, Hyogo, Japan.
   [Takesue, Yoshio] Hyogo Coll Med, Dept Infect Control & Prevent, Nishinomiya, Hyogo, Japan.
C3 Hyogo Medical University; Hyogo Medical University
RP Uchino, M (通讯作者)，Hyogo Coll Med, Dept Surg, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
EM uchino2s@hyo-med.ac.jp
OI Takesue, Yoshio/0000-0002-8635-6416
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NR 16
TC 42
Z9 48
U1 2
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-4886
EI 1421-9883
J9 DIGEST SURG
JI Dig. Surg.
PY 2016
VL 33
IS 6
BP 449
EP 454
DI 10.1159/000446550
PG 6
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA DR8GR
UT WOS:000380136900001
PM 27246708
DA 2026-07-24
ER

PT J
AU Anesäter, E
   Roupé, M
   Robertsson, P
   Borgquist, O
   Torbrand, C
   Ingemansson, R
   Lindstedt, S
   Malmsjö, M
AF Anesater, Erik
   Roupe, Markus
   Robertsson, Peter
   Borgquist, Ola
   Torbrand, Christian
   Ingemansson, Richard
   Lindstedt, Sandra
   Malmsjo, Malin
TI The influence on wound contraction and fluid evacuation of a rigid disc
   inserted to protect exposed organs during negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Fluid removal; Negative pressure wound therapy; Protective disc; Wound
   contraction; Wound healing
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS;
   METALLOPROTEINASES; EXPERIENCE; MARKERS; ULCERS
AB The use of a rigid disc as a barrier between the wound bed and the wound filler during negative pressure wound therapy (NPWT) has been suggested to prevent damage to exposed organs. However, it is important to determine that the effects of NPWT, such as wound contraction and fluid removal, are maintained during treatment despite the use of a barrier. This study was performed to examine the effect of NPWT on wound contraction and fluid evacuation in the presence of a rigid disc. Peripheral wounds were created on the backs of eight pigs. The wounds were filled with foam, and rigid discs of different designs were inserted between the wound bed and the foam. Wound contraction and fluid evacuation were measured after application of continuous NPWT at -80 mmHg. Wound contraction was similar in the presence and the absence of a rigid disc (84 +/- 4% and 83 +/- 3%, respectively, compared with baseline). Furthermore, the rigid disc did not affect wound fluid removal compared with ordinary NPWT (e.g. after 120 seconds, 71 +/- 4 ml was removed in the presence and 73 +/- 3 ml was removed in the absence of a disc). This study shows that a rigid barrier may be placed under the wound filler to protect exposed structures during NPWT without affecting wound contraction and fluid removal, which are two crucial features of NPWT.
C1 [Anesater, Erik; Roupe, Markus; Robertsson, Peter; Borgquist, Ola; Torbrand, Christian; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Torbrand, Christian; Ingemansson, Richard; Lindstedt, Sandra; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Torbrand, Christian; Ingemansson, Richard; Lindstedt, Sandra] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Torbrand, Christian/HIZ-8092-2022; Roupé, Markus/K-6502-2014; Borgquist,
   Ola/AAO-6451-2020; Lindstedt, Sandra/AEM-2892-2022
OI Torbrand, Christian/0000-0001-6442-7554; Ingemansson,
   Richard/0000-0001-7623-8953; Roupé, Markus/0000-0001-5472-8134; Maljö,
   Malin/0000-0001-9849-9599; Lindstedt, Sandra/0000-0003-4484-6473
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NR 36
TC 9
Z9 10
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 393
EP 399
DI 10.1111/j.1742-481X.2011.00805.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600010
PM 21585660
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Moog, P
   Jensch, M
   Betzl, J
   Bauer, AT
   Cerny, MK
   Schmauss, D
   Kükrek, H
   Erne, H
   Machens, HG
   Megerle, K
AF Moog, Philipp
   Jensch, Maryna
   Betzl, Julia
   Bauer, Anna-Theresa
   Cerny, Michael K.
   Schmauss, Daniel
   Kuekrek, Haydar
   Erne, Holger
   Machens, Hans-Guenther
   Megerle, Kai
TI Bacterial bioburden of wounds: influence of debridement and
   negative-pressure wound therapy (NPWT)
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bacterial bioburden; bacterial levels; dressing; infection; microbiology
   of wounds; negative-pressure wound therapy; NPWT; ulcer; VAC; VAC
   therapy; VAC therapy bioburden; wound; wound treatment
ID VACUUM-ASSISTED CLOSURE; MICROBIOLOGY; INFECTION; ULCERS
AB Objective: To clarify the role of microbiological swabs in surgical decision-making, we investigated the effect of negative-pressure wound therapy (NPWT) and serial surgical debridement on bacterial bioburden in hard-to-heal wounds and ultimately correlated them with the success of surgical closure.
   Method: All patients were treated with surgical debridement, jet lavage and NPWT before their wounds were finally closed. The treatment effect was assessed by correlating microbiological swabs obtained immediately after intervention with those obtained after removal of the dressings during the following surgical procedures. The result of the last microbiological swab taken before definitive surgical closure was correlated with the requirement for revision surgery.
   Results: We included the results of 704 microbiological swabs from 97 patients in 110 wound localisations in this monocentric, retrospective study. NPWT did not improve bacterial bioburden in 77% of cases and the duration of NPWT did not affect the result. Furthermore, no significant effect of NPWT could be found for either anaerobic (p=0.96) or aerobic bacteria (p=0.43). In contrast, surgical debridement increased bacterial load in approximately 60% of cases. If sterile wound swabs could be obtained at all, it was during the first four surgical debridements in 60% of patients; after that only 10% became sterile.
   Conclusions: Sterile microbiological wound swabs before surgical closure were associated with lower rates of revision surgery, while low or medium bacterial loads did not increase revision rates.
C1 [Moog, Philipp; Jensch, Maryna; Betzl, Julia; Bauer, Anna-Theresa; Cerny, Michael K.; Kuekrek, Haydar; Erne, Holger; Machens, Hans-Guenther; Megerle, Kai] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
   [Schmauss, Daniel] Osped Reg Lugano, Dept Plast Reconstruct & Aesthet Surg, Lugano, Switzerland.
C3 Technical University of Munich
RP Moog, P (通讯作者)，Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, D-81675 Munich, Germany.
EM philipp.moog1@mri.tum.de
RI Kuekrek, Haydar/NVM-7556-2025; /ABF-2085-2020
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NR 28
TC 9
Z9 12
U1 0
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG
PY 2021
VL 30
IS 8
BP 604
EP 611
DI 10.12968/jowc.2021.30.8.604
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UA5VV
UT WOS:000685230500004
PM 34382852
DA 2026-07-24
ER

PT J
AU Vallejo-Carmona, L
AF Vallejo-Carmona, Leticia
TI Structure-guided negative pressure wound therapy (NPWT): personalised
   tissue biomodulation with an NPWT system in adults and older adults
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE Negative pressure wound therapy; near-infrared spectroscopy; wound
   healing; perfusion; tissue oxygenation; biomodulation
ID VACUUM-ASSISTED CLOSURE; SILVER; RECOMMENDATIONS; MULTICENTER
AB Background: Negative pressure wound therapy(NPWT) has revolutionised the management of complex wounds via mechanisms such as microdeformation, angiogenesis and exudate control. However, its clinical effect has historically only been evaluated by qualitative and visual parameters. This study integrates near-infrared spectroscopy (NIRS) as a biofeedback tool to quantify physiological response to NPWT in real time. Objective: This study aimed to quantitatively demonstrate the physiological and structural changes induced by an NPWT system in patients with complex wounds, measured using NIRS. Methods: A prospective real-world observational study was conducted with a cohort of 23 patients with 33 wounds. Structural and physiological parameters were documented before and after NPWT treatment. Random-intercept mixed-effect statistical models and pre-post comparison tests were used to assess clinical and physiological significance. Results: The data showed a progressive reduction in wound area and volume, accompanied by an increase in tissue oxygen saturation and a sustained decrease in deoxygenated haemoglobin. These findings, objectively quantified through NIRS as a real-time biofeedback tool, highlight the improvement in oxygenation and wound-bed perfusion and support the hypothesis of tissue biomodulation induced by NPWT. Conclusion: The integration of NIRS redefines the clinical role of NPWT, allowing therapy to be customised based on specific physiological data. This combination represents a new frontier in precision wound medicine. The results of this study provide a foundation for a new generation of clinical decisions in advanced wound management.
C1 [Vallejo-Carmona, Leticia] Wound Care Plus Educ & Res Ctr, Puerto Rico Wound Healing Soc, San Juan, PR 00910 USA.
   [Vallejo-Carmona, Leticia] Wound & Ulcer Care Clin San Juan, Wound & Ulcer Ctr Florida, San Juan, PR 00918 USA.
   [Vallejo-Carmona, Leticia] Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00926 USA.
C3 Universidad Ana G. Mendez
RP Vallejo-Carmona, L (通讯作者)，Wound Care Plus Educ & Res Ctr, Puerto Rico Wound Healing Soc, San Juan, PR 00910 USA.; Vallejo-Carmona, L (通讯作者)，Wound & Ulcer Care Clin San Juan, Wound & Ulcer Ctr Florida, San Juan, PR 00918 USA.; Vallejo-Carmona, L (通讯作者)，Ana G Mendez Univ, Dept Hlth Sci, San Juan, PR 00926 USA.
FU Smith+Nephew
FX Smith+Nephew provided funding to enable Dr Vallejo to collect real-world
   data on the standard of care use of the utilised NPWT system (RENASYS
   lozenge EDGE, Smith+Nephew, Hull, UK) and provided support with
   statistical analysis of the results. Smith+Nephew had no role in patient
   management or clinical decision making, and all interpretations and
   conclusions are those of the author.
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2025
VL 34
SU 11E
PG 24
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 9VH4V
UT WOS:001615875400001
DA 2026-07-24
ER

PT J
AU Baek, S
   Park, JH
AF Baek, Seungchul
   Park, Jun Ho
TI Negative Pressure Wound Therapy (NPWT) after Hybrid Reconstruction of
   Occipital Pressure Sore Using Local Flap and Skin Graft
SO MEDICINA-LITHUANIA
LA English
DT Article
DE pressure sores; occipital scalp; negative pressure wound therapy; local
   flap; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE; ACELLULAR DERMAL MATRIX; SCALP; ULCERS
AB Background and objectives: Pressure sores are a common medical burden among patients, particularly those who are bedridden or frail. Surgical management of occipital pressure sores poses unique challenges due to limited elasticity and the spherical shape of the scalp. This study aims to evaluate the efficacy and safety of a novel reconstruction method utilizing a local transpositional flap and split-thickness skin graft with negative pressure wound therapy (NPWT) for occipital pressure sore treatment. Material and methods: A retrospective analysis was performed on patients with occipital pressure sores who underwent hybrid reconstructions using a local flap and split-thickness skin graft in conjunction with NPWT. Surgical outcomes, including flap survival rate, graft take percentage, and complications, were assessed. A comparative analysis was performed between the NPWT group and the conventional dressing group. Results: The NPWT group (n = 24) demonstrated a significantly higher mean graft take percentage at postoperative day 14 compared with the conventional dressing group (n = 22) (98.2% vs. 81.2%, p < 0.05). No significant difference in flap survival rate was observed between the two groups. Conclusions: As the aging population continues to grow, occipital pressure sores have gained significant attention as a crucial medical condition. The innovative surgical method incorporating NPWT offers an efficient and safe treatment option for patients with occipital pressure sores, potentially establishing itself as the future gold standard for managing this condition.
C1 [Baek, Seungchul; Park, Jun Ho] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, Seoul 07061, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital
RP Park, JH (通讯作者)，Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, Seoul 07061, South Korea.
EM jsean1@naver.com
RI Park, Jun Ho/HPH-3570-2023
OI Park, Jun Ho/0000-0003-0235-1261; BAEK, SEUNGCHUL/0000-0001-6979-0934
FU Seoul National University Hospital Research Fund [0420214050]
FX This research was supported by a clinical research grant-in-aid from
   Seoul National University Hospital Research Fund (No. 0420214050).
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NR 39
TC 6
Z9 8
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUL
PY 2023
VL 59
IS 7
AR 1342
DI 10.3390/medicina59071342
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N4JD0
UT WOS:001036684400001
PM 37512153
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Sakai, G
   Suzuki, T
   Hishikawa, T
   Shirai, Y
   Kurozumi, T
   Shindo, M
AF Sakai, G.
   Suzuki, T.
   Hishikawa, T.
   Shirai, Y.
   Kurozumi, T.
   Shindo, M.
TI Primary reattachment of avulsed skin flaps with negative pressure wound
   therapy in degloving injuries of the lower extremity
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative-pressure wound therapy; Degloving injury; Skin graft; Lower
   extremity
ID VACUUM-ASSISTED CLOSURE; TECHNICAL REFINEMENT; OPEN FRACTURES;
   MANAGEMENT; GRAFTS; TRIAL; FOOT
AB Large avulsed skin flaps of the lower extremity caused by degloving injuries eventually develop skin necrosis in most cases. The current treatment option involves excision of the degloved skin and reapplication as a full-or split-thickness skin graft. We considered that reattachment of avulsed skin flaps without excision would be theoretically beneficial, since some circulation may remain around the connected pedicle and thus facilitate graft take. Furthermore, securing the skin to the original anatomic position is much easier using retained landmarks. We treated a total of 12 patients (13 cases) with degloving injuries of the lower extremity. In all cases, the avulsed skin flap was defatted and sewn back to the original position, then negative-pressure wound therapy was applied over those grafts as a bolster for approximately 7 days. Most of the avulsed skin flap took excellently, particularly close to the connected pedicle. Nine cases did not need any additional surgical procedures. Four cases required secondary skin graft for a small area of open wound due to partial necrosis of the defatted skin, as well as the raw surface left by the primary skin defect in the initial operation. Primary reattachment of the avulsed skin flaps without excision is convenient and efficient to cover the open wound over the exposed fascia and periosteum in degloving injuries. This would potentially offer a better alternative to definitive wound closure. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Sakai, G.; Suzuki, T.; Hishikawa, T.; Shirai, Y.; Kurozumi, T.; Shindo, M.] Teikyo Univ, Sch Med, Dept Trauma, Tokyo, Japan.
   [Sakai, G.; Suzuki, T.; Hishikawa, T.; Shirai, Y.; Kurozumi, T.; Shindo, M.] Teikyo Univ, Sch Med, Reconstruct Ctr, Tokyo, Japan.
   [Sakai, G.] Nagoya City Univ, Grad Sch Med Sci, Dept Orthoped Surg, Nagoya, Aichi, Japan.
C3 Teikyo University; Teikyo University; Nagoya City University
RP Suzuki, T (通讯作者)，Teikyo Univ, Sch Med, Dept Trauma, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738606, Japan.; Suzuki, T (通讯作者)，Teikyo Univ, Sch Med, Reconstruct Ctr, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738606, Japan.
EM takashisuzuki911@yahoo.co.jp
RI KUROZUMI, TAKETO/AAL-3485-2020
OI KUROZUMI, TAKETO/0000-0003-0270-7993
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NR 27
TC 22
Z9 27
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JAN
PY 2017
VL 48
IS 1
BP 137
EP 141
DI 10.1016/j.injury.2016.10.026
PG 5
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA EF7YF
UT WOS:000390544600024
PM 27788928
DA 2026-07-24
ER

PT J
AU Dettmers, R
   Brekelmans, W
   Leijnen, M
   van der Burg, BB
   Ritchie, E
AF Dettmers, Robert
   Brekelmans, Wouter
   Leijnen, Michiel
   van der Burg, Boudewijn Borger
   Ritchie, Ewan
TI Negative Pressure Wound Therapy With Instillation and Dwell Time Used to
   Treat Infected Orthopedic Implants: A 4-patient Case Series
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case study; wound infection; osteosynthesis; fracture; negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; FRACTURES; IMPACT
AB Infection following orthopedic implants for bone fixation or joint replacement is always serious and may require removal of the osteosynthetic material. Negative pressure wound therapy with instillation and dwell time (NPWTi-d) is an emerging therapy for the treatment of complex wounds, including infected wounds with osteosynthetic material. The purpose of this case study was to evaluate the outcomes of 4 patients (1 man, 3 women; age range 49 to 71 years) with a postoperative wound infection (POWI) following fracture repair and internal fixation. All patients were at high risk for surgical complications, including infections. Standard infection treatments (antibiotics) had been unsuccessful. Based on the available literature, a NPWTi-d protocol was developed. Following surgical debridement, wounds were instilled with polyhexanide biguanide with a set dwell time of 15 minutes, followed by continuous NPWTi-d of -125 mm Hg for 4 hours. The system was changed every 3 to 4 days until sufficient granulation tissue was evident and negative pressure without instillation could be used. Systemic antibiotics were continued in all patients. Granulation tissue was found to be sufficient in 12 to 35 days in the 4 cases, no recurrence of infection was noted, and the osteosynthesis material remained in place. No adverse events were observed. Research is needed to compare the safety and effectiveness of this adjunct treatment in the management of challenging wounds to other patient and wound management approaches.
C1 [Dettmers, Robert] Alrijne Hosp Leiderdorp, Trauma Surg, Leiderdorp, Netherlands.
   [Dettmers, Robert] Alrijne Hosp Leiderdorp, Wound Care, Leiderdorp, Netherlands.
   [Brekelmans, Wouter; Leijnen, Michiel; van der Burg, Boudewijn Borger; Ritchie, Ewan] Alrijne Hosp Leiderdorp, Leiderdorp, Netherlands.
RP Dettmers, R (通讯作者)，Alrijne Hosp Leiderdorp, Dept Gen Surg, Simon Smitweg 1, NL-2353 GA Leiderdorp, Netherlands.
EM R.C.dettmers@lumc.nl
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NR 20
TC 12
Z9 15
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD SEP
PY 2016
VL 62
IS 9
BP 30
EP 40
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EL3FJ
UT WOS:000394504700003
PM 27668478
DA 2026-07-24
ER

PT J
AU Lo Torto, F
   Ruggiero, M
   Parisi, P
   Borab, Z
   Sergi, M
   Carlesimo, B
AF Lo Torto, Federico
   Ruggiero, Marco
   Parisi, Paola
   Borab, Zachary
   Sergi, Manuel
   Carlesimo, Bruno
TI The effectiveness of negative pressure therapy on infected wounds:
   preliminary results
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wound; Daptomicin; Negative pressure wound therapy; Vacuum
   Assisted Closure therapy
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; STERNAL
   OSTEOMYELITIS; DAPTOMYCIN; IMPACT
AB Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment. Wound infection is considered a relative contraindication. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability to increase the antibiotic concentration in the damaged and infected tissues. Patients who presented with ulcers infected with daptomycin-sensitive bacteria were eligible to be enrolled in this prospective study. They were given antibiotic therapy with daptomycin with a specific protocol. A biopsy of the lesion was carried out to detect tissue concentration of the drug at time 0. Afterwards, the patients were subjected to VAC therapy. At the end of VAC therapy, a second lesion biopsy was performed and analysed to detect tissue concentration of the drug at time 1. A control group was enrolled in which patients followed the same protocol, but they were treated with traditional dressings. Fisher's exact test was used to compare the two groups. The results highlighted a significant increase in the concentration of antibiotics in the study group tissue; the improvement was sensibly lower in the control group. Statistical differences were not found between the two groups. The preliminary analysis of the data showed an important increase of antibiotic concentration in the tissue after VAC therapy. Despite the encouraging data, it is necessary to broaden the sample of patients and perform the same study with other antibiotics.
C1 [Lo Torto, Federico; Parisi, Paola; Carlesimo, Bruno] Sapienza Univ Rome, UO Plast Reconstruct Surg, P Valdoni Dept Surg, Rome, Italy.
   [Ruggiero, Marco] Policlin Luigi Di Liegro, Rome, Italy.
   [Borab, Zachary] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
   [Sergi, Manuel] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, Teramo, Italy.
C3 Sapienza University Rome; Drexel University; University of Teramo
RP Lo Torto, F (通讯作者)，Sapienza Univ Rome, UO Plast Reconstruct Surg, P Valdoni Dept Surg, Policlin Umberto 1, Viale Policlin 155, I-00161 Rome, Italy.
EM federicolotorto@gmail.com
RI Sergi, Manuel/ABC-4334-2020; Torto, Federico/AAY-1852-2021; PARISI,
   PAOLA/ACJ-8116-2022
OI PARISI, PAOLA/0000-0003-2639-2957; Borab, Zachary/0000-0002-6832-9916
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NR 27
TC 24
Z9 25
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2017
VL 14
IS 6
BP 909
EP 914
DI 10.1111/iwj.12725
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FO0HN
UT WOS:000416424400003
PM 28198150
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Xia, CY
   Yu, AX
   Qi, BW
   Zhou, M
   Li, ZH
   Wang, WY
AF Xia, Cheng-Yan
   Yu, Ai-Xi
   Qi, Baiwen
   Zhou, Min
   Li, Zong-Huan
   Wang, Wei-Yang
TI Analysis of blood flow and local expression of angiogenesis-associated
   growth factors in infected wounds treated with negative pressure wound
   therapy
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE negative pressure wound therapy; angiogenesis-associated growth factors;
   protein biochip array; blood flow; infected wound
ID VACUUM-ASSISTED CLOSURE; IN-VIVO; DIABETIC MICE; TISSUE; CELLS; SKIN;
   EGF; ANGIOPOIETIN-2; LEPTIN; TRIAL
AB Angiogenesis is involved in the wound healing process. Increased angiogenesis and blood flow constitute a major mechanism of negative pressure wound therapy (NPWT), which has been shown to facilitate the healing of infected wounds. However, the effect on the expression of angiogensis-related growth factor remains unknown. The goal of the current study was to investigate the angiogenic factor levels prior to and following NPWT in infected wounds. A total of 20 patients with infected wounds treated with NPWT were included in the study. Patients acted as their own control; the postoperative measurements of patients were considered as the experimental group, while preoperative measurements were considered as the controlled group. Blood flow was recorded prior to and during NPWT. A total of 10 angiogensis-related growth factors were detected using a protein biochip array to analyze the change in protein levels prior to NPWT, and on the third day during NPWT. All wounds were successfully reconstructed by skin grafting or using local flaps following NPWT. NPWT resulted in significantly increased blood flow in the wound. There was a significant increase in vascular endothelial growth factor (VEGF), EGF, platelet-derived growth factor and angiotesin-2 following NPWT, while basic fibroblast growth factor decreased significantly. NPWT affects the local expression of angiogenesis-associated growth factors, which represents another mechanism to explain how NPWT accelerates wound healing.
C1 [Xia, Cheng-Yan; Yu, Ai-Xi; Qi, Baiwen; Zhou, Min; Li, Zong-Huan; Wang, Wei-Yang] Wuhan Univ, Dept Microorthopaed, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Dept Microorthopaed, Zhongnan Hosp, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Science Funds of China [81171713]; Doctoral candidate
   Independent research of Wuhan University [2012303020203]
FX This study was funded by grants from the National Science Funds of China
   (project code, 81171713), and by the Doctoral candidate Independent
   research of Wuhan University (grant no. 2012303020203).
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NR 42
TC 50
Z9 62
U1 0
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2014
VL 9
IS 5
BP 1749
EP 1754
DI 10.3892/mmr.2014.1997
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AJ3HR
UT WOS:000337557600034
PM 24584462
OA Bronze
DA 2026-07-24
ER

PT J
AU Arti, H
   Khorami, M
   Ebrahimi-Nejad, V
AF Arti, Hamidreza
   Khorami, Mohsen
   Ebrahimi-Nejad, Vahid
TI Comparison of negative pressure wound therapy (NPWT) & conventional
   wound dressings in the open fracture wounds
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Wound healing; Negative Pressure Wound Therapy; Conventional Wound
   Dressings; Infection
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION; PREVENTION; INFECTION; COVERAGE
AB Objective: Successful closure is a primary step of treatment in open fracture wounds. Delayed healing or complications can lead to increased treatment duration, costs and disability rates. The aim of this study was to compare Negative Pressure Wound Therapy (NPWT) and conventional wound dressings in patients with open fracture wounds.
   Methods: In a prospective randomized clinical trial study, 90 patients with open fractures that were referred for treatment were enrolled between February 2013 to March 2015. Patients were divided into two groups. Group I underwent NPWT and group II underwent conventional wound dressing. Then patients were followed up for one month. Within the one month, the number of dressing change varied based on the extent of the wound. Duration of wound healing, presence of infection and the number of hospitalization days in these patients were recorded and compared at the end of the study between the two groups. Questionnaires and check lists were used to collect data. Analysis was done with SPSS 20, paired sample T-test, and chi-square tests. P<0.05 was considered significant.
   Results: There was a significant difference between the rate of wound healing in the group one or NPWT group and group II (conventional wound dressings) P<0.05. There was no significant difference between two groups in incidence of infection (P=0.6).
   Conclusion: Using NPWT expedites the healing process of extremity wounds. It is more economical and can be considered as a substitute for the treatment of extremity wounds.
C1 [Arti, Hamidreza; Khorami, Mohsen; Ebrahimi-Nejad, Vahid] Ahvaz Jundishapur Univ Med Sci, Dept Orthoped Surg, Ahvaz, Iran.
   [Arti, Hamidreza; Khorami, Mohsen; Ebrahimi-Nejad, Vahid] Ahvaz Jundishapur Univ Med Sci, Trauma Res Ctr, Sch Med, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Arti, H (通讯作者)，Ahvaz Jundishapur Univ Med Sci, Dept Orthoped Surg, Ahvaz, Iran.; Arti, H (通讯作者)，Ahvaz Jundishapur Univ Med Sci, Trauma Res Ctr, Sch Med, Ahvaz, Iran.
EM hamidrezaarti@gmail.com
RI /B-9570-2009
FU Ahwaz Jundishapur University of Medical Sciences
FX We thank Vice Chancellor for research of Ahwaz Jundishapur University of
   Medical Sciences for supporting this research. This paper is derived
   from a specialty thesis of Dr. Vahid Ebrahimi-Nejad resident of
   Orthopaedic Surgery in Ahvaz Jundishapur University of Medical Sciences.
   The authors also thank to Golestan clinical research development unit.
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NR 26
TC 35
Z9 38
U1 1
U2 11
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2016
VL 32
IS 1
BP 65
EP 69
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC6GN
UT WOS:000369318000015
PM 27022347
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ohno, R
   Yoshimatsu, G
   Itatani, Y
   Okamura, R
   Yoshida, Y
   Maekawa, H
   Hoshino, N
   Hida, K
   Obama, K
   Hasegawa, S
AF Ohno, Ryo
   Yoshimatsu, Gumpei
   Itatani, Yoshiro
   Okamura, Ryosuke
   Yoshida, Yu
   Maekawa, Hisatsugu
   Hoshino, Nobuaki
   Hida, Koya
   Obama, Kazutaka
   Hasegawa, Suguru
TI Prophylactic negative pressure wound therapy with Prevena™ to prevent
   perineal surgical site infection
SO SURGERY TODAY
LA English
DT Article
DE Surgical site infection; Prophylactic negative-pressure wound therapy;
   Perineal wounds; Abdominoperineal resection; Total pelvic exenteration
ID VACUUM-ASSISTED CLOSURE; ABDOMINOPERINEAL RESECTION; RECTAL-CANCER;
   RECONSTRUCTION; COMPLICATIONS; MANAGEMENT; EXCISION; UTILITY
AB PurposeSurgical site infection (SSI) of perineal wounds after abdominoperineal resection (APR) or total pelvic exenteration (TPE) for pelvic malignancies is a common postoperative complication. Although several attempts have been made to prevent this complication, SSI of perineal wounds remain common. The efficacy of prophylactic negative-pressure wound therapy (NPWT) in abdominal surgery has been reported; however, few studies have focused on perineal wounds, where the incidence of SSI is particularly high. This study investigated the prophylactic effect of NPWT on closed perineal wounds after APR/TPE to prevent SSI.MethodsThis study enrolled 127 consecutive patients with malignant tumors who underwent elective APR/TPE between January 2013 and December 2022. We used the Prevena (TM) incision management system (IMS) on the perineal wound in 10 patients for prophylactic NPWT (pNPWT group), whereas 117 patients underwent conventional primary closure (cPC group). We compared the incidence of perineal wound SSI between the groups and explored the risk factors associated with SSI.ResultsPatients' backgrounds were essentially the same between the groups. There were no SSI cases in the pNPWT group, whereas 29 patients (25%) in the cPC group had SSI (P = 0.067). Exploratory analyses revealed that a body mass index >= 25, disinfection method, and neoadjuvant chemotherapy were significantly correlated with SSI in perineal wounds.ConclusionProphylactic NPWT for closed perineal wounds after APR/TPE in patients with malignancies can be effective in preventing SSI.
C1 [Ohno, Ryo; Itatani, Yoshiro; Okamura, Ryosuke; Yoshida, Yu; Maekawa, Hisatsugu; Hoshino, Nobuaki; Hida, Koya; Obama, Kazutaka] Kyoto Univ, Grad Sch Med, Dept Surg, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan.
   [Ohno, Ryo; Yoshimatsu, Gumpei; Hasegawa, Suguru] Fukuoka Univ, Fac Med, Dept Gastroenterol Surg, 7-45-1 Nanakuma,Jonan Ku, Fukuoka 8140180, Japan.
C3 Kyoto University; Fukuoka University
RP Itatani, Y (通讯作者)，Kyoto Univ, Grad Sch Med, Dept Surg, 54 Shogoin Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan.
EM itatani@kuhp.kyoto-u.ac.jp
RI ; Yoshimatsu, Gumpei/LYO-8890-2024; OBAMA, KAZUTAKA/AAW-8263-2021; Hida,
   Koya/AFU-1462-2022; Maekawa, Hisatsugu/MSW-9355-2025; Itatani,
   Yoshiro/GXA-0613-2022
OI Itatani, Yoshiro/0000-0001-7356-7065; 
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NR 25
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD DEC
PY 2025
VL 55
IS 12
BP 1945
EP 1952
DI 10.1007/s00595-025-03102-1
EA JUL 2025
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9OS9U
UT WOS:001530556900001
PM 40676202
DA 2026-07-24
ER

PT J
AU Pellino, G
   Sciaudone, G
   Candilio, G
   Campitiello, F
   Selvaggi, F
   Canonico, S
AF Pellino, Gianluca
   Sciaudone, Guido
   Candilio, Giuseppe
   Campitiello, Ferdinando
   Selvaggi, Francesco
   Canonico, Silvestro
TI Effects of a New Pocket Device for Negative Pressure Wound Therapy on
   Surgical Wounds of Patients Affected With Crohn's Disease: A Pilot Trial
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure wound therapy; instrumentation; methods; patient
   satisfaction; wound healing; surgical site infections; Crohn's disease
ID INFLAMMATORY-BOWEL-DISEASE; VACUUM-ASSISTED CLOSURE; SITE INFECTION;
   INTESTINAL WALL; OPEN ABDOMEN; PREVENTION; SURGERY; PROPHYLAXIS;
   INCISIONS; LAPAROSTOMY
AB Introduction. Surgical site infections (SSIs) affect costs of care and prolong length of stay. Crohn's disease (CD) represents an independent risk factor for SSI. The risk can be further increased by concomitant administration of immunosuppressive drugs and poor performance status at the time of surgery. Patients suffering from CD often need more than one surgical intervention during life, sometimes requiring fashioning of a stoma. The aim of this pilot study was to compare a portable device for negative pressure wound therapy (PICO, Smith & Nephew, London, UK) to conventional gauze dressings in patients undergoing surgery for stricturing CD. Methods. Between January 2010 and November 2011, this controlled trial enrolled 30 patients, who were assigned to treatment with either PICO (n = 13) or conventional dressings (n = 17). Each patient completed a 3-month follow-up. Results. Patients receiving PICO experienced significantly less postoperative wound complications (P = .001) and SSI (P = .017) compared with those who received conventional dressings. This resulted in shorter hospital stay (P = .0007). No significant differences in cosmetic results were found. Conclusion. These data suggest that PICO allows faster and safe discharge by reducing the incidence of SSI and wound-related complications in selected patients undergoing surgical intervention for stricturing CD. This could be particularly useful in patients receiving steroids.
C1 [Pellino, Gianluca; Sciaudone, Guido; Candilio, Giuseppe; Campitiello, Ferdinando; Selvaggi, Francesco; Canonico, Silvestro] Univ Naples 2, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Selvaggi, F (通讯作者)，Univ Naples 2, Dept Surg, Piazza Miraglia 5, I-80138 Naples, Italy.
EM fselvaggi@hotmail.com
RI ; Selvaggi, Francesco/HSH-7500-2023; Pellino, Gianluca/B-8458-2015
OI SCIAUDONE, Guido/0000-0003-4221-8502; Selvaggi,
   Francesco/0000-0002-3219-3797; Pellino, Gianluca/0000-0002-8322-6421
FU Smith & Nephew, London, United Kingdom
FX The Chief of the Unit where the study was carried out received a funding
   from Smith & Nephew, London, United Kingdom, to buy the devices employed
   in the present study. Results were not submitted or shown to Smith &
   Nephew.
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NR 37
TC 53
Z9 54
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2014
VL 21
IS 2
BP 204
EP 212
DI 10.1177/1553350613496906
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AF2WR
UT WOS:000334573700022
PM 23883481
DA 2026-07-24
ER

PT J
AU Ma, ZJ
   Li, ZH
   Shou, KQ
   Jian, C
   Li, PC
   Niu, YH
   Qi, BW
   Yu, AX
AF Ma, Zhanjun
   Li, Zonghuan
   Shou, Kangquan
   Jian, Chao
   Li, Pengcheng
   Niu, Yahui
   Qi, Baiwen
   Yu, Aixi
TI Negative pressure wound therapy: Regulating blood flow perfusion and
   microvessel maturation through microvascular pericytes
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE blood flow perfusion; collagen type IV; negative pressure wound therapy;
   pericytes; vessel maturation
ID VACUUM-ASSISTED CLOSURE; TUMOR ANGIOGENESIS; VESSEL MATURATION;
   RECRUITMENT; ANGIOPOIETINS; HETEROGENEITY
AB Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms. We also aimed to investigate the association between pericytes and collagen type IV. For this purpose, we created a rat model of diabetic wounds and microvascular blood flow perfusion was detected using a laser Doppler blood perfusion imager. The expression levels of angiogenin-1, tyrosine phosphorylation of tyrosine kinase receptor-2 (Tie-2), alpha-smooth muscle actin (alpha-SMA) and collagen type IV were detected and analyzed through immunohistochemistry, immunofluorescence, RT-qPCR and western blot analysis. The results revealed that NPWT promoted the overexpression of angiogenin-1, Tie-2, alpha-SMA and collagen type IV, and significantly increased blood flow perfusion coupled with microvessel maturation in the NPWT group at the later stages (7-10 days) of wound healing. Our results suggested that NPWT can preferentially enhance vessel maturation and increase the number of pericytes, thus regulating blood flow perfusion. On the other hand, pericytes and collagen type IV had a mutual interaction, promoting microvessel maturation.
C1 [Ma, Zhanjun; Li, Zonghuan; Shou, Kangquan; Jian, Chao; Li, Pengcheng; Niu, Yahui; Qi, Baiwen; Yu, Aixi] Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Qi, BW; Yu, AX (通讯作者)，Wuhan Univ, Dept Orthoped, Zhongnan Hosp, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM wb002162@whu.edu.cn; yuaixi@whu.edu.cn
RI Li, Pengcheng/ABF-5376-2021; /E-6566-2018
FU National Natural Science Foundation of China [81572163]; Hubei National
   Natural Science Fund [2014CFB751]
FX This study was supported by the National Natural Science Foundation of
   China (no. 81572163) and by the Hubei National Natural Science Fund
   projects (no. 2014CFB751). We would like to acknowledge the Wuhan VSD
   Medical Science and Technology, Co., Ltd. (Wuhan, China) for supplying
   the vacuum material. We would also like to thank the Medical Science
   Experimentation Center of Wuhan University providing the experiment
   equipment. This study has been satisfactorily edited for proper English
   by an agent of the English Editing Service of Experimental Biology and
   Medicine.
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NR 45
TC 54
Z9 73
U1 0
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2017
VL 40
IS 5
BP 1415
EP 1425
DI 10.3892/ijmm.2017.3131
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FK3PS
UT WOS:000413398800012
PM 28901392
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Wang, ZT
   Cao, JL
   Yuan, P
   Wang, LM
   He, ZH
   Lv, W
   Hu, J
AF Wang, Zhi-Tian
   Cao, Jin-Lin
   Yuan, Ping
   Wang, Lu-Ming
   He, Zhe-Hao
   Lv, Wang
   Hu, Jian
TI A novel facilitated negative-pressure wound therapy for thoracic
   incision infection after esophagectomy
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Negative-pressure wound therapy (NPWT); novel facilitated device;
   thoracic incision infection; esophagectomy
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; MANAGEMENT
AB Background: Negative-pressure wound therapy (NPWT) is the therapeutic management of traumatic soft-tissue wounds and infections. The efficacy of NPWT in the treatment of thoracic incision infection is unclear. We assess the effectiveness and safety of a novel facilitated NPWT for thoracic incision infection after esophagectomy.
   Methods: Between Jan. 2013 and Mar. 2016, 380 patients underwent open esophagectomy in our department. Forty-five patients with thoracic incision infection were retrospectively reviewed. Of these patients, 25 were treated with NPWT and 20 patients were treated with open wound dressing. The patients' clinical demographic data, postoperative outcomes and wound treatment cost are reviewed.
   Results: The thoracic incision infection rate was 11.8%. All of the incision infections were cured in the hospital or on an outpatient basis. No allergic reactions or other side effects occurred with NPWT. Although the patients who were treated with NPWT did not have a significantly shorter postoperative hospital stay than those treated with open wound dressing (P=0.092), the use of NPWT therapy for thoracic incision infection led to a shorter wound healing times (13 vs. 20 days; P=0.004) and a lower wound treatment cost (P=0.020).
   Conclusions: Thoracic incision infection is a common complication of esophagectomy. NPWT is a safe and effective therapeutic management for thoracic incision infection that is associated with shortened wound healing times and reduced wound treatment costs than traditional open wound treatment.
C1 [Wang, Zhi-Tian; Cao, Jin-Lin; Yuan, Ping; Wang, Lu-Ming; He, Zhe-Hao; Lv, Wang; Hu, Jian] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Thorac Surg, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Hu, J (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Thorac Surg, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM hujian_med2@163.com
CR Alexander JW, 2011, ANN SURG, V253, P1082, DOI 10.1097/SLA.0b013e31821175f8
   [Anonymous], ANN SURG
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NR 22
TC 1
Z9 4
U1 0
U2 3
PU PIONEER BIOSCIENCE PUBL CO
PI HONG KONG
PA 9A GOLD SHINE TOWER, 346-348 QUEEN'S RD CENTRAL, SHEUNG WAN, HONG KONG,
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD APR
PY 2017
VL 9
IS 4
SI SI
BP 1113
EP 1118
DI 10.21037/jtd.2017.03.160
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA EW4NS
UT WOS:000402478800056
PM 28523167
OA gold
DA 2026-07-24
ER

PT J
AU Wu, J
   Qin, Y
   Li, ZR
   Li, JT
   Li, LT
   Tao, S
   Liu, DH
AF Wu, Jie
   Qin, Yong
   Li, Zhirui
   Li, Jiantao
   Li, Litao
   Tao, Sheng
   Liu, Daohong
TI Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA
   network construction in negative pressure wound therapy
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy (NPWT); next-generation sequencing;
   transcriptome; noncoding RNAs
ID VACUUM-ASSISTED CLOSURE; DOWN-REGULATION; INFLAMMATION; MICRORNAS;
   TARGET; CD45
AB Background: This study aims to explore the molecular mechanism of negative pressure wound therapy (NPWT) at the transcriptome level through whole transcriptome sequencing and biometric analysis.
   Methods: A rat skin defect model was constructed and randomly divided into a NPWT group and a gauze group. The tissue in the center of the wound was used for whole transcriptome sequencing, and differentially expressed messenger RNAs (DEmRNAs), long noncoding RNAs (DElncRNAs), and microRNAs (DEmiRNAs) were identified between the two groups. Quantitative real time-polymerase chain reaction (qRT-PCR) analysis was used to verify the sequencing results. Functional enrichment analysis, pathway analysis, and protein-protein interaction (PPI) network analysis of DEmRNAs were conducted. Through bioinformatics analysis, a lncRNA-associated competing endogenous RNA (ceRNA) network was identified and constructed.
   Results: We detected 896 DEmRNAs, 1,471 DElncRNAs, and 20 DEmiRNAs between the two groups. qRT-PCR verified the sequencing results. Functional analysis showed that DEmRNAs were mainly enriched in immune system processes and the Notch signaling pathway. Protein tyrosine phosphatase receptor type C (PTPRC) and signal transducer and activator of transcription 1 (STAT1) were the central hub nodes in the PPI analysis. The ceRNA network contained 11 mRNAs, 15 lncRNAs, and 4 miRNAs.
   Conclusions: We identified several DEmRNAs, DElncRNAs, and DEmiRNAs between the NPWT treatment group and the control group. These findings may provide new insights into the pathophysiological mechanism of NPWT and wound healing.
C1 [Wu, Jie; Li, Litao; Tao, Sheng; Liu, Daohong] Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
   [Qin, Yong] Harbin Med Univ, Dept Orthoped, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China.
   [Li, Zhirui] Peoples Liberat Army Gen Hosp, Dept Orthoped, Hainan Hosp, Sanya, Peoples R China.
   [Li, Zhirui; Li, Jiantao; Li, Litao; Tao, Sheng; Liu, Daohong] Peoples Liberat Army Gen Hosp, Senior Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.
   [Li, Jiantao; Liu, Daohong] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Harbin Medical
   University; Chinese People's Liberation Army General Hospital; Chinese
   People's Liberation Army General Hospital
RP Tao, S; Liu, DH (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
EM taoshphy@126.com; domb@vip.sina.com
RI ; Li, Zhirui/OJT-0490-2025
OI Wu, Jie/0000-0002-6572-9762; 
FU Major Project of Military Logistics Research [AWS17J004-02-13]
FX This study was supported by the Major Project of Military Logistics
   Research (No. AWS17J004-02-13).
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NR 45
TC 4
Z9 5
U1 0
U2 10
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD SEP
PY 2021
VL 9
IS 17
AR 1383
DI 10.21037/atm-21-3626
EA AUG 2021
PG 14
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA ZN8RK
UT WOS:000693235600001
PM 34733935
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Li, TT
   Zhang, LH
   Han, L
   Wang, GQ
   Yin, P
   Li, ZR
   Zhang, LC
   Guo, Q
   Liu, DH
   Tang, PF
AF Li, Tongtong
   Zhang, Lihai
   Han, Li
   Wang, Guoqi
   Yin, Peng
   Li, Zhirui
   Zhang, Licheng
   Guo, Qi
   Liu, Daohong
   Tang, Peifu
TI Early application of negative pressure wound therapy to acute wounds
   contaminated with Staphylococcus aureus: An effective approach to
   preventing biofilm formation
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE acute wound; bacterial contamination; negative pressure wound therapy;
   early application; biofilm prevention
ID PSEUDOMONAS-AERUGINOSA BIOFILM; VACUUM-ASSISTED CLOSURE; IN-VITRO;
   BACTERIAL BIOFILMS; INFLAMMATORY RESPONSES; INFECTED WOUNDS;
   IMMUNE-SYSTEM; MECHANISMS; EPIDERMIDIS; MODEL
AB Negative pressure wound therapy (NPWT) has been demonstrated to be effective at preventing biofilm-associated infections; however, its role in biofilm prevention is unknown. The present study evaluated the effect of NPWT on biofilm prevention when rapidly initiated following wound contamination. Full-thickness dermal wounds (8 mm) were created in rabbit ears and inoculated with green fluorescent protein-labeled Staphylococcus aureus (S. aureus). At 6 h following inoculation, continuous NPWT at -125 mmHg was initiated, with the wounds on the contralateral ear left untreated in order to serve as self-controls. S. aureus rapidly formed mature biofilms in the wound beds post-inoculation, with a persistent bacterial burden of similar to 10(5)-10(7) colony-forming units (CFUs)/wound and impaired wound healing. Compared with the untreated group, NPWT resulted in a significant reduction in biofilm matrix, which was verified by scanning electron microscopy and epifluorescence. A reduction in bacterial counts followed (P<0.05) with similar to 10(3) CFUs/wound on postoperative day 13 and improvement in all healing parameters (P<0.05) relative to control wounds. The results of the present investigation suggest that NPWT is an effective strategy to impeding the formation of S. aureus wound biofilms when initiated rapidly following bacterial contamination. The early application of NPWT, aimed at biofilm prevention, may improve wound care.
C1 [Li, Tongtong; Yin, Peng; Guo, Qi] Nankai Univ, Coll Med, Dept Clin Med, Tianjin 300071, Peoples R China.
   [Li, Tongtong; Zhang, Lihai; Wang, Guoqi; Yin, Peng; Li, Zhirui; Zhang, Licheng; Guo, Qi; Tang, Peifu] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Han, Li] Chinese PLA Inst Dis Control & Prevent, Ctr Hosp Infect Control, Beijing 100071, Peoples R China.
   [Liu, Daohong] 309 Hosp PLA, Dept Orthoped, Beijing 100091, Peoples R China.
C3 Nankai University; Chinese People's Liberation Army General Hospital
RP Tang, PF (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM tangpeifu301@sina.cn
RI GUO, QI/HSE-6359-2023; Li, Zhirui/OJT-0490-2025
OI Tang, Peifu/0000-0003-4279-1704
FU National Natural Science Foundation of China [81472112]
FX The present study was supported by a grant from the National Natural
   Science Foundation of China (grant no. 81472112).
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NR 51
TC 24
Z9 33
U1 0
U2 27
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2016
VL 11
IS 3
BP 769
EP 776
DI 10.3892/etm.2016.3008
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DC9PV
UT WOS:000369554400011
PM 26997991
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Aljehani, Y
   Alrashaid, F
   El-bawab, H
   Alkhaldi, N
   Alsadery, H
   Alayyaf, N
   Alsaikhan, J
   Alshamekh, S
AF Aljehani, Yasser
   Alrashaid, Farouk
   El-bawab, Hatem
   Alkhaldi, Naif
   Alsadery, Hmood
   Alayyaf, Norah
   Alsaikhan, Jana
   Alshamekh, Sumiyah
TI The Utility of Negative Pressure Wound Therapy in the Management of
   Complex Deep Cardiothoracic Surgical Site Infections
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE cardiothoracic; complex deep surgical site infection; empyema;
   mediastinitis; negative pressure wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; SURGERY; EMPYEMA
AB Background. Complex deep surgical site infection in the cardiothoracic surgery patient that reaches the sternum and even the mediastinum, causing osteomyelitis and mediastinitis, is associated with high rates of morbidity and mortality. Negative pressure wound therapy (NPWT) can aid in achieving favorable outcomes in patients with complex surgical site infections by promoting wound healing and shortening the hospital stay. NPWT is widely recognized for its advantages and has recently been used in both cardiothoracic and non-cardiothoracic settings. Objective. To evaluate the efficacy of NPWT in the management of complex deep surgical site infection after cardiothoracic surgery. Materials and Methods. A retrospective chart review of all complex cardiothoracic cases admitted to the cardiac and thoracic surgery divisions for surgical intervention to treat postoperative surgical wound infections. Results. A total of 18 patients were included, with a male -to -female ratio of 5:4. The mean (SD) age was 48.7 (16.5) years. The cases reviewed were complex, and the duration of the NPWT application ranged from 4 days to 120 days, with an average hospital stay of 62.8 days. Seventyeight percent of patients required antibiotics (or had positive wound cultures); in 55.6% of these patients, polymicrobial infection was detected. No major complications were related to NPWT. Conclusion. The study findings show that using NPWT in complex deep sternal and thoracic infections can enhance wound healing, shorten the hospital stay, and decrease morbidity and mortality secondary to wound infection in cardiothoracic patients.
C1 [Aljehani, Yasser; Alrashaid, Farouk; El-bawab, Hatem; Alkhaldi, Naif; Alsadery, Hmood; Alayyaf, Norah; Alsaikhan, Jana; Alshamekh, Sumiyah] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Gen Surg, Dammam, Saudi Arabia.
   [Aljehani, Yasser] Imam Abdulrahman Bin Faisal Univ, King Fahd Hosp Univ, Gen Surg, Al Khobar 00000, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University; Imam Abdulrahman Bin Faisal
   University
RP Aljehani, Y (通讯作者)，Imam Abdulrahman Bin Faisal Univ, King Fahd Hosp Univ, Gen Surg, Al Khobar 00000, Dammam, Saudi Arabia.
EM yjehani@iau.edu.sa
RI Elbawab, Hatem/U-5996-2019
OI Elbawab, Hatem/0000-0003-0515-8221
CR Aljehani Y, 2016, CASE REP SURG, V2016, DOI 10.1155/2016/6805736
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   Aru GM, 2010, ANN THORAC SURG, V90, P266, DOI 10.1016/j.athoracsur.2010.04.092
   Chen Y, 2016, ONCOL LETT, V12, P757, DOI 10.3892/ol.2016.4654
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   Rocco G, 2014, ANN THORAC SURG, V98, P291, DOI 10.1016/j.athoracsur.2014.04.022
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
   Sherman G, 2020, PEDIATR CRIT CARE ME, V21, P150, DOI 10.1097/PCC.0000000000002131
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   Varker KA, 2006, ANN THORAC SURG, V81, P723, DOI 10.1016/j.athoracsur.2004.10.040
   Wu CC, 2015, ADV SKIN WOUND CARE, V28, P21, DOI 10.1097/01.ASW.0000459038.81701.fb
NR 23
TC 0
Z9 0
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2024
VL 36
IS 5
BP 170
EP 176
DI 10.25270/wnds/23133
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA UJ1Y5
UT WOS:001247610900006
PM 38861213
DA 2026-07-24
ER

PT J
AU Danno, K
   Matsuda, C
   Miyazaki, S
   Komori, T
   Nakanishi, M
   Motoori, M
   Kashiwazaki, M
   Fujitani, K
AF Danno, Katsuki
   Matsuda, Chu
   Miyazaki, Susumu
   Komori, Takamichi
   Nakanishi, Megumi
   Motoori, Masaaki
   Kashiwazaki, Masaki
   Fujitani, Kazumasa
TI Efficacy of Negative-Pressure Wound Therapy for Preventing Surgical Site
   Infections after Surgery for Peritonitis Attributable to
   Lower-Gastrointestinal Perforation: A Single-Institution Experience
SO SURGICAL INFECTIONS
LA English
DT Article
DE delayed primary closure; lower-gastrointestinal perforation; negative
   pressure wound therapy; prevention; surgical site infection
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; DELAYED PRIMARY
   CLOSURE; COLORECTAL SURGERY; INCISIONAL HERNIA; ABDOMINAL WOUNDS;
   APPENDICITIS; LAPAROTOMY; MANAGEMENT
AB Background and Purpose: For patients at high risk, such as those with lower-gastrointestinal perforations, it is important to establish a preventive method that reduces the incidence of surgical site infections (SSIs) significantly. We applied negative-pressure wound therapy (NPWT) as part of a delayed primary closure approach to prevent SSIs. This study evaluated the value of this technique.
   Methods: We included prospectively 28 patients undergoing abdominal surgery for peritonitis caused by a lower-gastrointestinal perforation between May 2014 and November 2015. Historical controls comprised retrospective data on 19 patients who had undergone primary suturing for managing peritonitis incisions for a lower-gastrointestinal perforation from January to December 2013.
   Results: We found a significant association between the SSI incidence and the type of incision management (10.7% with NPWT and delayed closure vs. 63.2% with primary suturing; p < 0.001). There was no significant difference between the groups in the length of the hospital stay (22 days for NPWT and delayed closure vs. 27 days for primary suturing; p = 0.45). No severe adverse events were observed related to NPWT.
   Conclusion: The use of NPWT and delayed primary closure was an effective measure for preventing SSI in patients undergoing abdominal surgery for peritonitis caused by lower-gastrointestinal perforation.
C1 [Danno, Katsuki; Miyazaki, Susumu; Komori, Takamichi; Motoori, Masaaki; Kashiwazaki, Masaki; Fujitani, Kazumasa] Osaka Gen Med Ctr, Dept Surg Gastroenterol, Osaka, Japan.
   [Nakanishi, Megumi] Osaka Gen Med Ctr, Dept Nursing, Osaka, Japan.
   [Matsuda, Chu] Osaka Univ, Grad Sch Med, Dept Surg Gastroenterol, Suita, Osaka, Japan.
C3 University of Osaka
RP Danno, K (通讯作者)，Minoh City Hosp, Dept Surg, 5-7-1 Kayano, Osaka 5620014, Japan.
EM danno_ka@yahoo.co.jp
CR [Anonymous], 2016, Global Guidelines for the Prevention of Surgical Site Infection
   [Anonymous], 2013, VAC THER SYST SAF IN
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NR 23
TC 14
Z9 19
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD OCT
PY 2018
VL 19
IS 7
BP 711
EP 716
DI 10.1089/sur.2018.134
PG 6
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA GW5YH
UT WOS:000447018600012
PM 30183559
DA 2026-07-24
ER

PT J
AU Skrinjar, E
   Duschek, N
   Bayer, GS
   Assadian, O
   Koulas, S
   Hirsch, K
   Basic, J
   Assadian, A
AF Skrinjar, Edda
   Duschek, Nikolaus
   Bayer, Gottfried S.
   Assadian, Ojan
   Koulas, Spyridon
   Hirsch, Kornelia
   Basic, Jelena
   Assadian, Afshin
TI Randomized controlled trial comparing the combination of a polymeric
   membrane dressing plus negative pressure wound therapy against negative
   pressure wound therapy alone: The WICVAC study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PAIN; INFECTIONS; MANAGEMENT; BLIND; FOAM
AB Negative pressure wound therapy (NPWT) is the treatment of choice for chronic wounds; yet, it is associated with considerable workload. Prompted by its nonadhesive and wound-healing properties, this study investigated the effect of an additional polymeric membrane interface dressing (PMD; PolyMem WIC) in NPWT. From October 2011 to April 2013, 60 consecutive patients with chronic leg wounds or surgical site infections after revascularization of lower extremities were randomly allocated to either treatment with conventional NPWT (control arm) or NPWT with an additional PMD (intervention arm). The primary outcome was wound healing achieved within 30 days, the secondary endpoints included: number of days between dressing changes, wound-related pain, cost efficiency, and occurrence of adverse events ( Identifier: NCT02399722). Forty-seven patients completed follow-up. No difference in wound healing was observed (p>0.05) between both study arms. The additional PMD allowed significantly longer wearing times (days) between dressing changes (intervention: 8.8 +/- 0.5, control: 4.8 +/- 0.2; p<0.001). Pain was slightly higher in patients randomized to NPWT alone (VAS score: 4.8 +/- 2.9) compared to NPWT+PMD (VAS score: 3.0 +/- 2.9, p=0.063). No wound infections were observed. Costs were reduced by 34% per patient in the intervention arm. These results suggest that the combination of NPWT and an additional interface PMD is a safe and economic method for the treatment of chronic wounds, which requires significantly fewer dressing changes for a comparable wound healing.
C1 [Skrinjar, Edda; Bayer, Gottfried S.; Koulas, Spyridon; Hirsch, Kornelia; Basic, Jelena; Assadian, Afshin] Wilhelminenhospital, Dept Vasc & Endovasc Surg, Pavillon 30B Montleartstr 37, A-1160 Vienna, Austria.
   [Duschek, Nikolaus] CHU Vaudois, Dept Dermatol & Venerol, Lausanne, Vaud, Switzerland.
   [Assadian, Ojan] Univ Huddersfield, Inst Skin Integr & Infect Prevent, Sch Human & Hlth Sci, Huddersfield, W Yorkshire, England.
C3 Wilhelminenspital; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Huddersfield
RP Skrinjar, E (通讯作者)，Wilhelminenhospital, Dept Vasc & Endovasc Surg, Pavillon 30B Montleartstr 37, A-1160 Vienna, Austria.
EM edda.skrinjar@gmx.at
RI Assadian, Ojan/H-9753-2019; Duschek, Nikolaus/KHX-7082-2024
OI Assadian, Ojan/0000-0003-0129-8761; Assadian, Ojan/0000-0003-0129-8761; 
FU Ferris Mfg. Corporation
FX Dr. Skrinjar received a travel grant from Ferris Mfg. Corporation for
   presenting preliminary findings of this evaluation at the EWMA
   Conference 2010.
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NR 27
TC 4
Z9 4
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP-OCT
PY 2016
VL 24
IS 5
BP 928
EP 935
DI 10.1111/wrr.12457
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DY9WD
UT WOS:000385485100019
PM 27313054
DA 2026-07-24
ER

PT J
AU Chen, M
   Yang, HJ
   Wang, F
   Wang, HS
AF Chen, Mei
   Yang, Haijing
   Wang, Fei
   Wang, Hongsheng
TI Vacuum sealing drainage: A novel treatment method for primary cutaneous
   Mycobacterium intracellulare infection
SO INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
LA English
DT Article
DE Cutaneous; Mycobacterium intracellulare; primary; vacuum sealing
   drainage
ID AVIUM-INTRACELLULARE
AB The incidence of primary cutaneous Mycobacterium intracellulare infection is very low. We report a case of primary cutaneous M. intracellulare infection which presented as painful erythematous swelling of the right upper limb without systemic involvement. A novel technique of vacuum sealing drainage was successfully implemented after antimycobacterial treatment proved ineffective at the end of 3 months. Our technique also revealed some additional practical advantages.
C1 [Chen, Mei; Yang, Haijing; Wang, Fei] Southeast Univ, Zhongda Hosp, Sch Med, Dept Dermatol, Nanjing, Jiangsu, Peoples R China.
   [Wang, Hongsheng] Chinese Acad Med Sci, Inst Dermatol, Dept Jiangsu Key Lab Mol Biol Skin Dis & STIs, Nanjing, Jiangsu, Peoples R China.
   [Wang, Hongsheng] Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.
C3 Southeast University - China; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Institute of Dermatology - CAMS; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College
RP Wang, F (通讯作者)，Southeast Univ, Zhongda Hosp, Dept Dermatol, Dingjiaqiao Rd 87, Nanjing 210009, Jiangsu, Peoples R China.
EM ffwangfei@163.com
FU Mycobacteria Laboratory, the Institute of Dermatology, Chinese Academy
   of Medical Sciences and Peking Union Medical College
FX This work was supported by Mycobacteria Laboratory, the Institute of
   Dermatology, Chinese Academy of Medical Sciences and Peking Union
   Medical College.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 15
TC 2
Z9 4
U1 0
U2 18
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0378-6323
EI 0973-3922
J9 INDIAN J DERMATOL VE
JI Indian J. Dermatol. Venereol. Leprol.
PD NOV
PY 2019
VL 85
IS 6
BP 605
EP 608
DI 10.4103/ijdvl.IJDVL_873_17
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA JV0VI
UT WOS:000502085500005
PM 29974888
OA gold
DA 2026-07-24
ER

PT J
AU Klein, R
   Desvigne, MN
   Greenstein, E
   Napolitano, RJ Jr
   Milne, C
   Speyrer, MS
   Weir, D
AF Klein, Robert
   Desvigne, Michael N.
   Greenstein, Emily
   Napolitano Jr, Ralph J.
   Milne, Catherine
   Speyrer, Marcus S.
   Weir, Dot
TI Use of Silver Collagen Oxidized Regenerated Cellulose Dressings in
   Conjunction With Negative Pressure Wound Therapy: Expert Panel Consensus
   Recommendations
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE reticulated open cell foam dressing; silver collagen dressings; wound
   healing; Delphi technique; negative pressure wound therapy; oxidized
   regenerated cellulose dressings
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; DIABETIC FOOT
   ULCERS; CARE; STANDARD; METAANALYSIS; MANAGEMENT; IMPACT
AB Background. A new indication for use of silver collagen oxidized regenerated cellulose (ORC) dressing in conjunction with negative pressure wound therapy (NPWT) and reticulated open cell foam (ROCF) dressings has recently become available. Objective. An in-person meeting with 7 health care providers (HCPs) was held to identify clinical care settings and appropriate use of silver collagen ORC dressings in conjunction with NPWT and ROCF dressings. Methods. Consensus statements were developed using a modified Delphi technique. An additional 25 HCPs completed an anonymous survey on the consensus statements. Consensus was defined as >= 80% agreement among survey respondents. Results. Use of silver collagen ORC dressings with NPWT and ROCF dressings was recommended in inpatient and outpatient health care settings. Use in traumatic wounds, surgical wounds, diabetic ulcers, venous leg ulcers, and pressure injuries/ulcers was supported. Use was not recommended in the presence of exposed unprotected organs or exposed unprotected vessels, when the potential for inadequate wound hemostasis exists, acutely ischemic wounds, third-degree burns, or surgically closed incisions, or with patient hypersensitivity to product components. Conclusions. Limited evidence exists on use of NPWT in conjunction with silver collagen ORC dressings. A panel developed 12 consensus statements detailing the recommended and contraindicated uses of NPWT in conjunction with silver collagen ORC dressings.
C1 [Klein, Robert] Univ South Carolina, Sch Med, Greenville, SC 29607 USA.
   [Klein, Robert] Prisma Hlth, Greenville, SC 29605 USA.
   [Desvigne, Michael N.] Abrazo Arrowhead Hosp & Wound Clin, Glendale, AZ USA.
   [Greenstein, Emily] Essentia Hlth Fargo, Fargo, ND USA.
   [Napolitano Jr, Ralph J.] OrthoNeuro, Columbus, OH USA.
   [Napolitano Jr, Ralph J.] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH USA.
   [Milne, Catherine] Connecticut Clin Nursing Assoc LLC, Bristol, CT USA.
   [Speyrer, Marcus S.] Wound Treatment Ctr, Opelousas, LA USA.
   [Weir, Dot] Saratoga Hosp Ctr Wound Healing & Hyperbar Med, Saratoga Springs, NY USA.
C3 Prisma Health; University System of Ohio; Ohio University
RP Klein, R (通讯作者)，Univ South Carolina, Sch Med Greenville, Surg, 200C Patewood Dr,Suite 300, Greenville, SC 29615 USA.
EM robklein63@gmail.com
FX Acknowledgments: The authors thank Christopher Barrett, DPM; Saeed
   Chowdhry, MD; H. John Cooper, MD; Anthony Dardano, DO, FACS; Marcus
   Duda, MD; Amanda Estapa, NP; Elizabeth Faust, CRNP, CWOCN, CWS; Regina
   Fearmonti, MD; Luis Fernandez, MD, FACS, FASAS, FCCP, FCCM, FICS; Allen
   Gabriel, MD, FACS; Janis Harrison, RN, BSN, CWOCN; Daphne Hodges, RN,
   BSN; Luther H. Holton, MD; Ravi Karia, MD; Martha Kelso, RN, HBOT; Paul
   Kim, DPM, MS; Mary Anne Obst, RN, BSN, CCRN, CWON; Todd Shaffett, DNP,
   FNP, CWS, FACCWS, DAPWCA; Olivia Snodgrass, PA; Kerry Thibodeaux, MD,
   FACS; Casey Thomas, DO, FACOS, FACS; Colin Traynor, DPM, CWSP; Terry
   Treadwell, MD; Julie West, PA; and Phil Wrotslavsky, DPM, for their
   participation in the consensus statement survey. The authors also thank
   Ricardo Martinez, Julissa Ramos, and Julie M. Robertson (Solventum) for
   assistance with manuscript preparation and editing.
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NR 50
TC 1
Z9 1
U1 2
U2 9
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2024
VL 36
IS 8
BP 263
EP 273
DI 10.25270/wnds/24026
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G0G5R
UT WOS:001313503500004
PM 39241767
DA 2026-07-24
ER

PT J
AU Kim, TH
   Park, JH
AF Kim, Tae Hyung
   Park, Jun Ho
TI A novel negative pressure wound therapy (NPWT) monitoring system for
   postoperative flap management
SO MEDICINE
LA English
DT Article
DE free flap; negative pressure wound therapy; pedicled flap
ID VACUUM-ASSISTED CLOSURE; VENOUS CONGESTION; RECONSTRUCTION; SURVIVAL;
   OUTCOMES; SALVAGE; TISSUE
AB Various types of flaps are widely utilized as reconstructive options for patients with soft tissue defects. However, the postoperative monitoring of the flap requires a large amount of time and effort. The aim of this study was to evaluate the efficacy and safety of this novel monitoring procedure using negative pressure wound therapy (NPWT) immediately after the flap operations. A retrospective analysis was performed on patients who underwent free flaps and perforator flaps from March 2019 to December 2020. The flaps were managed by either novel NPWT method or conventional dressing. Among NPWT group, computed tomography angiography was performed in randomly selected 5 flaps on the third postoperative day for evaluation of pedicle compression. Statistical analysis was performed between the 2 groups. A total of 54 flaps were included in this study. Twenty seven flaps were managed using novel NPWT method and 27 flaps were managed using conventional dressing. There was no statistically significant difference in flap survival rates between the 2 groups (P = .91). The patency of flap pedicles in the NPWT group was confirmed by comparing the computed tomography angiography findings. The estimated total flap monitoring time and cost for 5 days was significantly decreased by the application of the novel NPWT monitoring system. Through the application of the novel postoperative monitoring system using NPWT, there is efficient evaluation of the flap. Furthermore, safe flap monitoring is possible with the reduced risk of infection by the avoidance of multiple manual dressing performed in the conventional method.
C1 [Kim, Tae Hyung; Park, Jun Ho] Soonchunhyang Univ, Dept Plast & Reconstruct Surg, Gumi Hosp, 1 Gongdan Ro 179, Gumi, Gyeonsangbuk Do, South Korea.
C3 Soonchunhyang University
RP Park, JH (通讯作者)，Seoul Natl Univ, Coll Med, Dept Plast & Reconstruct Surg, SMG SNU Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
EM jsean1@naver.com
OI Park, Jun Ho/0000-0003-0235-1261
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NR 30
TC 5
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV 5
PY 2021
VL 100
IS 44
AR e27671
DI 10.1097/MD.0000000000027671
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XL2QA
UT WOS:000727992700001
PM 34871244
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Shuler, MS
   Mowers, CC
   Dhodapkar, MM
   Greenberg, M
   Ngendahimana, D
   Freedman, BA
AF Shuler, Michael S.
   Mowers, Colton C.
   Dhodapkar, Meera M.
   Greenberg, Mitchell
   Ngendahimana, David
   Freedman, Brett A.
TI Contact Pressure Under Traditional Foam and Novel Thermoplastic
   Elastomer Negative Pressure Wound Therapy Interfaces
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE contact pressure; deep wound; foam dressing; negative pressure wound
   therapy; porcine explant; pressure mapping; pressure transduction;
   thermoplastic elastomer; wound filler; wound perfusion
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; LASER-DOPPLER;
   CONTRACTION; GAUZE; TRANSDUCTION
AB Negative pressure wound therapy relies on suction, commonly set to -125 mmHg, to evacuate wound fluid, but dysvascular and pressure injuries often respond unpredictably. Newton's third law indicates that negative pressure applies an equal and opposite contact pressure on the wound surface, and this study quantified this contact pressure across dressing types, wound configurations and suction levels. Using a porcine explant model, central and peripheral contact pressure measurements were obtained beneath black reticulated open cell foam, white foam and a novel thermoplastic elastomer dressing across plexiglass, intact skin, shallow and deep wounds under -50, -75 and -125 mmHg. Contact pressure increased proportionally with negative pressure, and multivariable modelling demonstrated that dressing type, wound type and suction level significantly influenced pressure, with negative pressure explaining most of the variance (0.77 and 0.68). Thermoplastic elastomer at -50 mmHg in deep wounds produced the lowest contact pressure, whereas black reticulated open cell foam and white foam at -125 mmHg generated elevated contact pressures of approximately +125 to +195 mmHg. These findings show that black reticulated open cell foam at conventional -125 mmHg can create hypoperfusion conditions, whereas thermoplastic elastomer consistently produces the lowest pressures and may enhance perfusion at lower suction levels, offering a physiologic explanation for improved clinical outcomes in dysvascular and pressure injuries treated with reduced negative pressure.
C1 [Shuler, Michael S.] Athens Orthoped Clin, Athens, GA 30606 USA.
   [Mowers, Colton C.] Rush Univ, Med Ctr, Chicago, IL USA.
   [Dhodapkar, Meera M.; Freedman, Brett A.] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [Greenberg, Mitchell] Geneva Fdn, Tacoma, WA USA.
   [Ngendahimana, David] Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland Hts, OH USA.
C3 Rush University; Mayo Clinic; University Hospitals of Cleveland; Rainbow
   Babies & Children's Hospital; University System of Ohio; Case Western
   Reserve University; Case Western Reserve University Hospital
RP Shuler, MS (通讯作者)，Athens Orthoped Clin, Athens, GA 30606 USA.
EM mshuler@ccthera.com
CR Allen D, 2023, WOUND REPAIR REGEN, V31, P349, DOI 10.1111/wrr.13084
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2026
VL 34
IS 2
AR e70157
DI 10.1111/wrr.70157
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA HK4EY
UT WOS:001756152700016
PM 41992494
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Jung, JA
   Yoo, KH
   Han, SK
   Lee, YN
   Jeong, SH
   Dhong, ES
   Kim, WK
AF Jung, Jae-A.
   Yoo, Ki-Hyun
   Han, Seung-Kyu
   Lee, Ye-Na
   Jeong, Seong-Ho
   Dhong, Eun-Sang
   Kim, Woo-Kyung
TI Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in
   Diabetic Feet
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; tissue oxygenation; diabetic foot
ID MICROVASCULAR BLOOD-FLOW; VACUUM-ASSISTED CLOSURE; AMPUTATION;
   PERFUSION; ARTERIAL
AB OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet.
   PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPO2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients.
   DESIGN: A TcPO2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of -125 mm Hg was applied until TcPO2 reached a steady state. The TcPO2 values for diabetic feet were measured before, during, and after NPWT.
   MAIN RESULTS: The TcPO2 levels decreased significantly after applying NPWT in all patients. Mean TcPO2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P < .01), respectively.
   CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic foot.
C1 [Jung, Jae-A.; Yoo, Ki-Hyun; Han, Seung-Kyu; Lee, Ye-Na; Jeong, Seong-Ho; Dhong, Eun-Sang; Kim, Woo-Kyung] Korea Univ, Guro Hosp, Dept Plast Surg, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Guro Hosp, Dept Plast Surg, Seoul, South Korea.
OI Dhong, Eun Sang/0000-0002-7521-0518
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NR 25
TC 21
Z9 22
U1 1
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD AUG
PY 2016
VL 29
IS 8
BP 364
EP 370
DI 10.1097/01.ASW.0000483038.18331.a4
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA DS2RL
UT WOS:000380631100006
PM 27429242
DA 2026-07-24
ER

PT J
AU Xu, NL
   Mi, W
AF Xu, Ning-Lu
   Mi, Wei
TI 被撤回的出版物: Effects of negative pressure wound therapy on wound infection
   and healing in patients with open fracture wounds: A meta-analysis
   (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE meta-analysis; negative pressure wound therapy; open fracture; wound
   healing; wound infection
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; LIMB
AB A meta-analysis was conducted to comprehensively evaluate the impact of negative pressure wound therapy (NPWT) on wound infection and healing in patients with open fracture wounds. Computer searches were performed in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the application of NPWT in open fracture wounds, with the search period covering the databases inception to September 2023. Two researchers independently screened the literature, extracted data and conducted quality assessments. Stata 17.0 software was employed for data analysis. Overall, 17 RCTs involving 1814 patients with open fracture wounds were included. The analysis revealed that compared with other treatment methods, NPWT significantly shortened the wound healing time (standardized mean difference [SMD] = -2.86, 95% confidence intervals [CI]: -3.51 to -2.20, p < 0.001) and fracture healing time (SMD = -3.14, 95% CI: -4.49 to -1.79, p < 0.001) in patients with open fracture wounds. It also significantly reduced the incidence of wound infection (odds ratio [OR] = 0.36, 95% CI: 0.23-0.56, p < 0.001) and complications (OR = 0.29, 95% CI: 0.20-0.40, p < 0.001). This study indicates that in the treatment of open fracture wounds, NPWT, compared with conventional treatment methods, can accelerate the healing of wounds and fractures, effectively control infections and reduce the occurrence of complications, demonstrating high safety.
C1 [Xu, Ning-Lu] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Traumatol, Wuhan, Peoples R China.
   [Mi, Wei] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Intervent Radiol, Wuhan, Peoples R China.
   [Mi, Wei] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Intervent Radiol, Wuhan 430064, Hubei, Peoples R China.
C3 Wuhan University of Science & Technology; Wuhan University of Science &
   Technology; Wuhan University of Science & Technology
RP Mi, W (通讯作者)，Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Intervent Radiol, Wuhan 430064, Hubei, Peoples R China.
EM wuhmiwei877835@163.com
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NR 47
TC 1
Z9 1
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2024
VL 21
IS 2
AR e14757
DI 10.1111/iwj.14757
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA HH4Z2
UT WOS:001158602000001
PM 42052983
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Stinner, DJ
   Hsu, JR
   Wenke, JC
AF Stinner, Daniel J.
   Hsu, Joseph R.
   Wenke, Joseph C.
TI Negative Pressure Wound Therapy Reduces the Effectiveness of Traditional
   Local Antibiotic Depot in a Large Complex Musculoskeletal Wound Animal
   Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE Negative pressure wound therapy; local antibiotics; bead pouch;
   orthopaedic infection
ID VACUUM-ASSISTED CLOSURE; BEADS; FRACTURES; RELEASE
AB Objectives: Negative pressure wound therapy (NPWT) has been used to help manage open wounds. Surgeons also often use local antibiotic depot as adjunctive therapy in an effort to reduce infection rates. These 2 techniques have been reported to be used in conjunction, but there are little data to support this practice. We sought to compare the contamination levels of wounds treated with the commonly used antibiotic bead pouch technique to wounds that received both antibiotic beads and NWPT.
   Methods: The effectiveness of a bead pouch was compared with antibiotic beads with NPWT. The anterior compartment and proximal tibia of goats were injured and inoculated with Staphylococcus aureus. Six hours later, the wounds were debrided and the animals were assigned to a group; the bacteria level was quantified immediately before and after initial debridement and 2 days after treatment.
   Results: The wounds in the antibiotic bead pouch group had 6-fold less bacteria than the augmented NPWT group, 11 + 2% versus 67 + 11% of baseline values, respectively (P = 0.01). As expected, high levels of the antibiotic were consistently recovered from the augmented NPWT effluent samples at all time points.
   Conclusions: NPWT reduces the effectiveness of local antibiotic depot. These results can provide surgeons with the information to personalize the adjunctive therapies to individual patients, with the degree of difficulty in managing the wound and concern for infection being the 2 variables dictating treatment.
C1 [Stinner, Daniel J.; Wenke, Joseph C.] USA, Dept Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
C3 United States Department of Defense; United States Army; Brooke Army
   Medical Center
RP Stinner, DJ (通讯作者)，USA, Dept Regenerat Med, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM daniel.stinner@gmail.com
RI Stinner, Daniel/KSM-9513-2024
OI Stinner, Daniel/0000-0002-8981-6262; Hsu, Joseph/0000-0001-9341-2554
FU intramural federal funding
FX This project was supported by intramural federal funding.
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NR 30
TC 35
Z9 40
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 512
EP 518
DI 10.1097/BOT.0b013e318251291b
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200016
PM 22495524
DA 2026-07-24
ER

PT J
AU Ooi, G
   Burton, P
   Packiyanathan, A
   Loh, D
   Chen, R
   Shaw, K
   Brown, W
   Nottle, P
AF Ooi, Geraldine
   Burton, Paul
   Packiyanathan, Andrew
   Loh, Damien
   Chen, Richard
   Shaw, Kalai
   Brown, Wendy
   Nottle, Peter
TI Indications and efficacy of endoscopic vacuum-assisted closure therapy
   for upper gastrointestinal perforations
SO ANZ JOURNAL OF SURGERY
LA English
DT Article
DE anastomotic leak; gastroscopy; negative-pressure wound therapy;
   oesophageal perforation; oesophagectomy
ID ANASTOMOTIC LEAKAGE; TREATMENT OPTIONS; MANAGEMENT; RESECTION
AB BackgroundEndoscopic vacuum-assisted closure (EndoVAC) therapy is a recent innovation described for use in upper gastrointestinal perforations and leaks, with reported success of 80-90%. It provides sepsis control and collapses the cavity preventing stasis, encouraging healing of the defect. Whilst promising, initial reports of this new technique have not established clear indications, feasibility and optimal technique.
   MethodsWe analysed all patients who underwent EndoVAC therapy between 2014 and 2016. The technique involved a standard gastroscope, nasogastric tube and vacuum-assisted closure dressing kit, with endoscopic placement of the polyurethane sponge. Data were collected on indication, technique, sepsis control, outcomes and drainage volumes.
   ResultsTen patients were treated. Average age was 56.712.3years. There were three mortalities. EndoVAC placement was feasible in nine patients and successful healing was observed in six patients. Failure was more likely in the cases of large (>8cm), chronic or complex cavities. A three-phase response was seen in successful cases, with initial reduction in external drainage (average: 143-17mL/day within 1week), followed by a progressive reduction in inflammatory markers (2weeks) and finally a healing phase with reduction in cavity size (3weeks).
   Conclusion EndoVAC therapy is a potentially useful adjunct to conventional treatments of a subset of upper gastrointestinal leaks and perforations when there is a contained cavity <8cm. It appears less effective in an uncontained perforation or chronically established tract. It has clear advantages of being easily applied with readily available equipment and disposables.
C1 [Ooi, Geraldine; Burton, Paul; Packiyanathan, Andrew; Loh, Damien; Chen, Richard; Shaw, Kalai; Brown, Wendy; Nottle, Peter] Alfred Hosp, Upper Gastrointestinal Surg Unit, Melbourne, Vic, Australia.
   [Ooi, Geraldine; Burton, Paul; Brown, Wendy] Monash Univ, Ctr Obes Res & Educ, Level 6,99 Commercial Rd, Melbourne, Vic 3181, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University
RP Ooi, G (通讯作者)，Monash Univ, Ctr Obes Res & Educ, Level 6,99 Commercial Rd, Melbourne, Vic 3181, Australia.
EM geraldine.ooi@monash.edu
RI Brown, Wendy/H-7130-2014
OI Brown, Wendy/0000-0002-0137-2688
FU Allergan, Inc.; National Health and Medical Research Council; Royal
   Australasian College of Surgeons
FX The Centre for Obesity Research and Education has received funding for
   research purposes from Allergan, Inc., the manufacturer of the LAP-BAND.
   Dr Ooi reports scholarships from the National Health and Medical
   Research Council and the Royal Australasian College of Surgeons. The
   remaining authors have no conflicts of interest.
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NR 18
TC 36
Z9 44
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-1433
EI 1445-2197
J9 ANZ J SURG
JI ANZ J. Surg.
PD APR
PY 2018
VL 88
IS 4
BP E257
EP E263
DI 10.1111/ans.13837
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GB3XS
UT WOS:000428994400007
PM 27860126
DA 2026-07-24
ER

PT J
AU Ehya, REM
   Zhao, Y
   Zheng, X
   Yi, WR
   Bounda, GA
   Li, ZH
   Xiao, WD
   Yu, AX
AF Ehya, Regis Ernest Mendame
   Zhao, Yong
   Zheng, Xun
   Yi, Wanrong
   Bounda, Guy-Armel
   Li, Zonghuan
   Xiao, Weidong
   Yu, Aixi
TI Comparative effectiveness study between negative pressure wound therapy
   and conventional wound dressing on perforator flap at the Chinese
   tertiary referral teaching hospital
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Traumatic wounds reconstructive closure; Perforator flap; Negative
   pressure wound therapy; Vacuum assisted closure therapy; Conventional
   wound dressing care
ID SKIN-GRAFTS; TRIAL; MANAGEMENT; MECHANISM; DEVICE; BURNS; LEG
AB Background: Perforator flap techniques with conventional wound dressing have being extensively used in the management of soft-tissue defects. However; the flap's survival rate is not always guaranteed and the wound healing time always long. The aim of this study was to investigate the clinical effectiveness use of a freshly transplanted perforator flap in conjunction with Vacuum-assisted closure (VAC) for better clinical outcomes.
   Methods: A prospective, randomized, effectiveness study comparing the clinical outcomes of VAC versus traditional wrap and bandages for the treatment of open wounds that required hospital admission and operative debridement using perforator flaps, was carried out from March 1, 2014 to March 31, 2016 at Wuhan University Zhongnan Hospital. Fifty-one eligible patients were randomized into two groups; study group (perforator flaps covered by VAC) and control group (perforator flaps covered by traditional wrap and bandages). The measured clinical endpoints included the time of the first post-operative dressing change, pain visual analogical scale, perforator flap infection rate, 95% perforator flap healing time and percentage of survived perforator flap.
   Results: There was no statistically significant difference in the demographic profiles in the two cohorts. There were statistically significant differences in the clinical endpoints in the two groups (p < 0.001; p < 0.05, Table 2).
   Conclusions: In summary, VAC combining with perforator flap technique, can diminish accumulated exudation of the transferring flap, protect against postoperative infection, prolong the interval between perforator flap relocation and first postoperative dressing change, decrease pain during removal of dressing, increase perforator flap survival rate, and shorten wound healing time, with a good aesthetic outcome, a good mobility and a satisfactory therapeutic result. (c) 2017 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.
C1 [Ehya, Regis Ernest Mendame; Zhao, Yong; Zheng, Xun; Yi, Wanrong; Li, Zonghuan; Xiao, Weidong; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.
   [Bounda, Guy-Armel] China Pharmaceut Univ, Dept Clin Pharm, Sch Basic Med & Clin Pharm, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.
   [Bounda, Guy-Armel] Sinomedica Co Ltd, 677 Nathan Rd, Kowloon, Hong Kong, Peoples R China.
C3 Wuhan University; China Pharmaceutical University
RP Ehya, REM (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China.; Yu, AX (通讯作者)，169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM mendameregis@yahoo.fr; yuaixi@whu.edu.cn
RI ; BOUNDA, Guy-Armel/D-3203-2014; Zheng, Xun/JEP-2802-2023
OI Mendame ehya, Regis ernest/0000-0003-3275-6649; BOUNDA,
   Guy-Armel/0000-0002-9237-0484; 
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NR 35
TC 6
Z9 6
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2017
VL 26
IS 4
BP 282
EP 288
DI 10.1016/j.jtv.2017.07.002
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA FP5NC
UT WOS:000417665200009
PM 28734659
DA 2026-07-24
ER

PT J
AU Andros, G
   Armstrong, DG
   Attinger, CE
   Boulton, AJM
   Frykberg, RG
   Joseph, WS
   Lavery, LA
   Morbach, S
   Niezgoda, JA
   Toursarkissian, B
AF Andros, George
   Armstrong, David G.
   Attinger, Christopher E.
   Boulton, Andrew J. M.
   Frykberg, Robert G.
   Joseph, Warren S.
   Lavery, Lawrence A.
   Morbach, Stephan
   Niezgoda, Jeffrey A.
   Toursarkissian, Boulos
TI Consensus statement on negative pressure wound therapy (VAC® therapy)
   for the management of diabetic foot wounds
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   MAJOR AMPUTATION; TISSUE EXPANSION; RANDOMIZED-TRIAL; RISK-FACTORS;
   ULCERATION; CARE; OUTCOMES
AB In 2004, a multidisciplinary expert panel convened at the Tucson Expert Consensus Conference (TECC) to determine appropriate use of negative pressure wound therapy as delivered by a Vacuum Assisted Closure(R) device (V.A.C.(R) Therapy, KCI, San Antonio, Tex) in the treatment of diabetic foot wounds. These guidelines were updated by a second multidisciplinary expert panel at a consensus conference on the use of V.A.C.(R) Therapy, held in February 2006, in Miami, Florida. This updated version of the guidelines summarizes current clinical evidence, provides practical guidance, offers best practices to clinicians treating diabetic foot wounds, and helps direct future research.
   The Miami consensus panel discussed the following 12 key questions regarding V.A.C.(R) Therapy: 1) How long should V.A.C.(R) Therapy be used in the treatment of a diabetic foot wound? 2) Should V.A.C.(R) Therapy be applied without debriding the wound? 3) How should the patient using V.A.C.(R) Therapy be evaluated on an outpatient basis? 4) When should V.A.C.(R) Therapy be applied following revascularization? 5) When should V.A.C.(R) Therapy be applied after incision, drainage, and debridement of infection? 6) Should V.A.C.(R) Therapy be applied over an active soft tissue infection? 7) How should V.A.C.(R) Therapy be used in patients with osteomyelitis? 8) How should noncompliance to V.A.C.(R) Therapy be defined? 9) How should V.A.C.(R) Therapy be used in combination with other modalities? 10) Should small, superficial wounds be considered for V.A.C.(R) Therapy? 11) How should success in the use of V.A.C.(R) Therapy be defined? 12) How can one combine effective offloading and V.A.C.(R) Therapy?
RI ; Niezgoda, Jeffrey/KZU-8352-2024
OI Morbach, Stephan/0000-0001-5498-1519; Lavery,
   Lawrence/0000-0002-7920-9952; 
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NR 145
TC 53
Z9 67
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2006
SU S
BP 1
EP 32
PG 32
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 061ER
UT WOS:000238854500001
DA 2026-07-24
ER

PT J
AU Andros, G
   Armstrong, DG
   Attinger, CE
   Boulton, AJM
   Frykberg, RG
   Joseph, WS
   Lavery, LA
   Morbach, S
   Niezgoda, JA
   Toursarkissian, B
AF Andros, George
   Armstrong, David G.
   Attinger, Christopher E.
   Boulton, Andrew J. M.
   Frykberg, Robert G.
   Joseph, Warren S.
   Lavery, Lawrence A.
   Morbach, Stephan
   Niezgoda, Jeffrey A.
   Toursarkissian, Boulos
TI Consensus statement on negative pressure wound therapy (VAC® Therapy)
   for the management of diabetic foot wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   RISK-FACTORS; MAJOR AMPUTATION; TISSUE EXPANSION; RANDOMIZED-TRIAL;
   ULCERATION; CARE; DRESSINGS
AB In 2004, a multidisciplinary expert panel convened at the Tucson Expert Consensus Conference (TECC) to determine appropriate use of negative pressure wound therapy as delivered by a Vacuum Assisted Closure(R) de-ice (VA.C.(R) Therapy, KCI, San Antonio, Tex) in the treatment of diabetic foot wounds. These guidelines were updated by a second multidisciplinary expert panel at a consensus conference on the use of V.A.C.(R) Therapy, held in February 2006, in Miami, Florida. This updated version of the guidelines summarizes current clinical evidence. provides practical guidance, offers best practices to clinicians treating diabetic foot wounds, and helps direct future research.
   The Miami consensus panel discussed the following 12 key questions regarding VA.C.(R) Therapy: 1) How tong should VA.C.(R) Therapy be used in the treatment of a diabetic foot wound? 2) Should VA.C.(R) Therapy be applied debriding the wound? 3) How should the patient using VA.C.(R) Therapy be evaluated on an Outpatient basis? 4) When should V.A.C.(R) Therapy be applied after incision VA.C.(R) Therapy be applied following revascularization? 5) When should V.A.C.(R) Therapy be applied after incision, drainage, and debridement of infection? 6) Should V.A.C.(R) Therapy be applied over an active soft tissue infection?)7) How should VA.C.(R) Therapy be used in patients with osteomyelitis? 8) How should noncompliance to VA.C.(R) Therapy be defined? 9) How should VA.C.(R) Therapy be used in combination With other modalities?, 10) Should small, superficial wounds be considered for VA.C.(R) Therapy? 11) How should success in the rise of V.A.C.(R) Therapy be defined? 12) How can one combine effective offloading and VA.C.(R) Therapy?
RI Niezgoda, Jeffrey/KZU-8352-2024
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   Alvarez JE, 2003, COLUMBIA J TRANS LAW, V42, P1
   ANDROS G, 1984, ARCH SURG-CHICAGO, V119, P1260
   [Anonymous], 1999, DIABETES CARE, V22, P1354, DOI DOI 10.2337/DIACARE.22.8.1354
   [Anonymous], 2005, Global Guideline for Type 2 Diabetes
   [Anonymous], INT DIABETES MONITOR
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   [Anonymous], 1985, DIABETES AM DIABETES
   [Anonymous], FOOT DIABETES
   [Anonymous], 2005, NAT DIAB FACT SHEET
   [Anonymous], LEV EV GRAD REC
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   Apelqvist J, 2000, DIABETES-METAB RES, V16, pS75, DOI 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR139>3.3.CO;2-#
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   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Armstrong DG, 2005, DIABETES CARE, V28, P551, DOI 10.2337/diacare.28.3.551
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   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
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NR 145
TC 6
Z9 8
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2006
SU S
BP 1
EP 32
PG 32
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 062QM
UT WOS:000238959600001
DA 2026-07-24
ER

PT J
AU Gheuens, L
   Roggeman, Q
   Cortebeeck, K
   Leyman, P
   Bernaerts, A
   De Foer, B
   Van Leemput, J
   van Dinther, J
AF Gheuens, Lisa
   Roggeman, Quinten
   Cortebeeck, Koen
   Leyman, Paul
   Bernaerts, Anja
   De Foer, Bert
   Van Leemput, Jan
   van Dinther, Joost
TI Pediatric necrotizing soft tissue infection after elective surgery: A
   case report and literature review
SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
LA English
DT Review
DE Necrotizing soft tissue infections; Pediatric; Head and neck surgery;
   Surgical debridement
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; NEGATIVE-PRESSURE;
   FASCIITIS; MANAGEMENT; DIAGNOSIS; CHILDREN; HEAD
AB Introduction: Necrotizing soft tissue infections (NSTIs) are rare but often lethal. Early diagnosis and aggressive surgical debridement are essential to achieve the best possible outcome.
   Case presentation: A 12-year old boy was diagnosed with a necrotizing soft tissue infection following elective revision surgery for functional impairment resulting from scar tissue of the neck. Fever and inflammation of the surgical wound manifested 24-36 hours postoperatively. Antibiotic therapy with amoxicillin-clavulanic acid was initiated, but the patient was unresponsive. Ultrasonography, a wound culture and surgical exploration confirmed the diagnosis. The culture was positive for a Streptococcus pyogenes infection and antibiotic treatment was switched to penicillin and clindamycin. Following the diagnosis, surgical debridement was performed subcutaneously, and only necrotic tissue was removed to preserve as much skin tissue as possible. After eradication of the infection, vacuum-assisted closure of the wound was used to close the subcutaneous space. The patient was discharged after 40 days.
   Conclusion: In this patient, we treated a necrotizing soft tissue infection with antibiotics, skin sparing surgeries and negative pressure wound therapy (NPWT). We used ultrasonography as imaging technique to help with the diagnosis. The extensiveness of surgical debridement was rather limited. We focused on opening all affected fascial layers. The surgical debridement was subcutaneous, and only necrotic tissue was removed. Because of the location in the neck, we tried to avoid an aggressive skin debridement to preserve as much skin tissue as possible. Negative pressure wound therapy is not frequently used in this context but it contributed to an enhanced wound healing. Ultrasonography for diagnosing NSTIs is useful, but the clinical findings and an explorative surgery will remain most important.
C1 [Gheuens, Lisa; Roggeman, Quinten; van Dinther, Joost] GZA Hosp, Dept ENT HNS, European Inst ORL HNS, Campus Sint Augustinus, Antwerp, Belgium.
   [Cortebeeck, Koen] GZA Hosp, Wound Care Unit, Campus Sint Augustinus, Antwerp, Belgium.
   [Leyman, Paul] GZA Hosp, Div Neonatal & Pediat Surg, Dept Gen & Digest Surg, Campus Sint Augustinus, Antwerp, Belgium.
   [Bernaerts, Anja; De Foer, Bert] GZA Hosp, Dept Radiol, Campus Sint Augustinus, Antwerp, Belgium.
   [Van Leemput, Jan] GZA Hosp, Intens Care Unit, Campus Sint Augustinus, Antwerp, Belgium.
RP Gheuens, L (通讯作者)，GZA Hosp, Dept ENT HNS, European Inst ORL HNS, Campus Sint Augustinus, Antwerp, Belgium.
EM Lisa.gheuens@uzgent.be
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NR 37
TC 4
Z9 5
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-5876
EI 1872-8464
J9 INT J PEDIATR OTORHI
JI Int. J. Pediatr. Otorhinolaryngol.
PD NOV
PY 2020
VL 138
AR 110195
DI 10.1016/j.ijporl.2020.110195
PG 6
WC Otorhinolaryngology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Pediatrics
GA OF4ID
UT WOS:000581172700008
PM 32705989
DA 2026-07-24
ER

PT J
AU Wilkes, R
   Zhao, Y
   Cunningham, K
   Kieswetter, K
   Haridas, B
AF Wilkes, R.
   Zhao, Y.
   Cunningham, K.
   Kieswetter, K.
   Haridas, B.
TI 3D strain measurement in soft tissue: Demonstration of a novel inverse
   finite element model algorithm on MicroCT images of a tissue phantom
   exposed to negative pressure wound therapy
SO JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; ENDOTHELIAL-CELLS;
   RANDOMIZED-TRIAL; GROWTH-CONTROL; BLOOD-FLOW; ANGIOGENESIS;
   DEFORMATIONS; TENSION; ULCERS
AB This study describes a novel system for acquiring the 3D strain field in soft tissue at sub-millimeter spatial resolution during negative pressure wound therapy (NPWT). Recent research in advanced wound treatment modalities theorizes that microdeformations induced by the application of sub-atmospheric (negative) pressure through V.A.C.(R) GranuFoam (R) Dressing, a reticulated open-cell polyurethane foam (ROCF), is instrumental in regulating the mechanobiology of granulation tissue formation [Saxena, V., Hwang, CW., Huang, S., Eichbaum, Q., Ingber, D., Orgill, D.P., 2004. Vacuum-assisted closure: Microdeformations of wounds and cell proliferation. Plast. Reconstr. Surg. 114, 1086-1096]. While the clinical response is unequivocal, measurement of deformations at the wound-dressing interface has not been possible due to the inaccessibility of the wound tissue beneath the sealed dressing. Here we describe the development of a bench-test wound model for microcomputed tomography (microCT) imaging of deformation induced by NPWT and an algorithm set for quantifying the 3D strain field at sub-millimeter resolution. Microdeformations induced in the tissue phantom revealed average tensile strains of 18%-23% at sub-atmospheric pressures of -50 to -200 mmHg (-6.7 to -26.7 kPa). The compressive strains (22%-24%) and shear strains (20%-23%) correlate with 2D FEM studies of microdeformational wound therapy in the reference cited above. We anticipate that strain signals quantified using this system can then be used in future research aimed at correlating the effects of mechanical loading on the phenotypic expression of dermal fibroblasts in acute and chronic ulcer models. Furthermore, the method developed here can be applied to continuum deformation analysis in other contexts, such as 3D cell culture via confocal microscopy, full scale CT and MRI imaging, and in machine vision. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Wilkes, R.] Kinet Concepts Inc, Global Res, Adv Mat Grp, San Antonio, TX 78249 USA.
   [Cunningham, K.; Haridas, B.] Device & Implant Innovat LLC, Mason, OH 45040 USA.
   [Haridas, B.] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45221 USA.
C3 University System of Ohio; University of Cincinnati
RP Wilkes, R (通讯作者)，Kinet Concepts Inc, Global Res, Adv Mat Grp, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM rob.wilkes@kcil.com
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NR 41
TC 26
Z9 30
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1751-6161
EI 1878-0180
J9 J MECH BEHAV BIOMED
JI J. Mech. Behav. Biomed. Mater.
PD JUL
PY 2009
VL 2
IS 3
BP 272
EP 287
DI 10.1016/j.jmbbm.2008.10.006
PG 16
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 430SO
UT WOS:000265009000007
PM 19627832
DA 2026-07-24
ER

PT J
AU Zhang, JS
   Ma, YQ
   Liang, XP
   Shi, B
AF Zhang, Jishen
   Ma, Yongqi
   Liang, Xiangping
   Shi, Bing
TI Applications of vacuum sealing drainage in treating seawater-immersed
   sulfur mustard injury
SO TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
LA English
DT Article
DE Seawater immersion; chemical weapon; sulfur mustard; intractable wound
ID NEGATIVE-PRESSURE THERAPY; MODEL; WOUNDS; VEGF
AB Vacuum sealing drainage has excellent therapeutic effects on the complex injuries. There is no relevant report on seawater-immersed sulfur mustard injury. The treatment effects were examined with miniature pigs. Injuries were performed on their back followed by vacuum sealing drainage at various pressures for nine days. Injured tissues were sampled up to 30 d after treatment and healing rates, levels of interleukin-6, tumor necrosis factor , and vascular endothelial growth factor were recorded. Vacuum sealing drainage enhances the healing of sulfur mustard wounds significantly, reduces the interleukin-6 and tumor necrosis factor levels in the wound, and increases the vascular endothelial growth factor expression. Pressure reduction by 180mmHg is the most suitable condition for vacuum treatment.
C1 [Zhang, Jishen; Shi, Bing] PLA, Dept Plast Surg, Hosp 309, Beijing, Peoples R China.
   [Ma, Yongqi; Liang, Xiangping] Dalian Xinhua Plast Hosp, Dept Plast Surg, Dalian, Liaoning Provin, Peoples R China.
RP Shi, B (通讯作者)，PLA, Dept Plast Surg, Hosp 309, Beijing, Peoples R China.
EM yy_309@sohu.com
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NR 20
TC 4
Z9 4
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0277-2248
EI 1029-0486
J9 TOXICOL ENVIRON CHEM
JI Toxicol Environ. Chem.
PY 2017
VL 99
IS 5-6
BP 975
EP 986
DI 10.1080/02772248.2017.1338702
PG 12
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA FA6YT
UT WOS:000405591700021
DA 2026-07-24
ER

PT J
AU Angulo, AR
   Caballero-Alvarado, J
   Sarmiento-Falen, J
   Zavaleta-Corvera, C
AF Angulo, Alexandra Rodriguez
   Caballero-Alvarado, Jose
   Sarmiento-Falen, Joaquin
   Zavaleta-Corvera, Carlos
TI Comparative Assessment of Negative Pressure Wound Therapy Versus
   Standard Treatment in Diabetic Foot Ulcers A Systematic Review and
   Meta-Analysis
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Conventional therapy; Diabetic foot ulcer; Effectiveness; Mellitus
   diabetes; Meta-analysis; Negative pressure wound therapy
ID VACUUM SEALING DRAINAGE
AB PURPOSE: The purpose of this systematic and metanalysis was to compare wound healing-related outcomes of negative pressure wound therapy (NPWT) to conventional therapy outcomes (time to granulation tissue formulation, ulcer depth, adverse effects amputation, pain, infection, and bleeding, along with hospital length of stay) for treatment of diabetic foot ulcers (DFU) in adults. METHODS: Systematic review and meta-analysis of pooled data. SEARCH STRATEGY:The electronic databases PubMed, Scopus, Web of Science, and Embase were searched. An artificial intelligence powered (Rayyan), proprietary software was used to retrieve, remove duplicates, and cite studies identified in our search. Two researchers and a conflict referee screened the studies in 2 phases; a title/abstract review, followed by reading all articles in full before identifying 12 studies included in this systematic review and metanalysis. RESULTS: Twelve studies were included in our metanalysis; 8 were clinical trials and 4 were observational studies. The pooled sample in the 8 clinical trials comprised 760 participants; 373 were managed with NPWT and 387 were managed with conventional therapy. No significant difference was observed for ulcer depth (P = .16). However, significant differences were found in mean difference in time to granulation tissue formation (P = .03), rate of amputation, pain (P = .01), infection rates (P = .005), and hospital length of stay (P < .001). The pooled sample evaluated in the 4 observational studies was 222; 100 were managed with NPWT and 122 with CT. Significant differences were found in time to granulation tissue formation (P < .001), amputation rates (P = .04), infection rate (P = .04), and hospital length of stay (P < .001). CONCLUSIONS: NPWT improves time to granulation tissue formation, reduces hospital stay, and the risk of secondary amputations, infections, and pain. Based on these findings we recommend incorporating NPWT as a standard component of DFU management.
C1 [Angulo, Alexandra Rodriguez; Caballero-Alvarado, Jose; Sarmiento-Falen, Joaquin; Zavaleta-Corvera, Carlos] Antenor Orrego Private Univ, Sch Med, Amer Sur Av 3145, Trujillo 13007, Peru.
C3 Universidad Privada Antenor Orrego
RP Zavaleta-Corvera, C (通讯作者)，Antenor Orrego Private Univ, Sch Med, Amer Sur Av 3145, Trujillo 13007, Peru.
EM aleroan96@gmail.com; jcaballeroalvarado@icloud.com;
   joaquinsarmiento1998@gmail.com; czavaletac3@upao.edu.pe
RI ; Zavaleta Corvera, Carlos/HPD-7962-2023
OI Caballero-Alvarado, Jose Antonio/0000-0001-8297-6901; Sarmiento,
   Joaquin/0009-0003-1309-2573; Zavaleta Corvera,
   Carlos/0000-0001-5918-8261
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NR 29
TC 3
Z9 3
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD MAY-JUN
PY 2025
VL 52
IS 3
BP 227
EP 238
DI 10.1097/WON.0000000000001164
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 2RP8G
UT WOS:001489651800002
PM 40377467
DA 2026-07-24
ER

PT J
AU Wu, YJ
   Chen, L
   Wu, SK
   Yu, LY
   Chen, MM
   Wang, JN
   Chen, JJ
   Pang, QJ
AF Wu, Yaojun
   Chen, Liang
   Wu, Shaokun
   Yu, Liying
   Chen, Mimi
   Wang, Jingnan
   Chen, Jiejie
   Pang, Qingjiang
TI Application of a simple skin stretching system and negative pressure
   wound therapy in repair of complex diabetic foot wounds
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Simple skin stretching system; Negative pressure wound therapy; Diabetic
   foot wounds
ID VACUUM SEALING DRAINAGE; CLOSURE; ULCERS; MANAGEMENT; SECURE; PLASMA
AB The management of complex diabetic foot wounds with large skin defects poses a challenge for surgeons. We presented a simple skin stretching system and negative pressure wound therapy for the repair of complex diabetic foot wounds to examine the effectiveness and safety.A total of 16 patients with diabetic foot ulcers were retrospectively reviewed between January 2015 and October 2020. All patients underwent the treatment by 3 stages. In stage 2, these difficult-to-close wounds of diabetes foot were residual. This method was applied to the wounds with a median defect size of 20.42 cm(2) (range, 4.71-66.76 cm(2)).The median time for closure of complex diabetic foot wounds was 14 days ranging from 8 to 19 days. With respect to the absolute rates of reduction, it was observed with a median of 1.86 cm(2)/day, ranging from 0.29 cm(2)/day to 8.35 cm(2)/day. In accordance with the localization of the defect, the patients were divided into 3 groups: side of the foot (37.5%), dorsum of the foot (50.0%), and others (12.5%). There was no statistical difference between side of the foot and dorsum of the foot in terms of the median defect size with P = 0.069 (Kruskal-Wallis test). Otherwise, there were statistically significant differences regarding the median time and the median absolute rates (P < 0.05; Kruskal-Wallis test). No severe complications were encountered in this study.In summary, our results show that application of the simple skin stretching system and NPWT is an effective and safe approach to complex diabetic foot wounds. Nevertheless, more attention should be paid to the appropriate patient selection and intraoperative judgment to ensure wound closure and avoid undue complications.
C1 [Wu, Yaojun; Chen, Liang; Wu, Shaokun; Yu, Liying; Chen, Mimi; Wang, Jingnan; Chen, Jiejie; Pang, Qingjiang] Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo Hosp 2, Dept Orthoped, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Chen, L (通讯作者)，Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo Hosp 2, Dept Orthoped, 41 Northwest St, Ningbo 315010, Zhejiang, Peoples R China.
EM alanchenl@aliyun.com
RI Wu, Shaokun/NXC-0398-2025
FU Natural Science Foundation of Ningbo City [2016A610146]; Medical and
   Health Science and Technology Program Foundation of Zhejiang Province
   [2020KY843, 2015KYB342]; Hwa Mei Foundation [2019HMKY10]
FX This study was supported by a grant from the Natural Science Foundation
   of Ningbo City (2016A610146), the Medical and Health Science and
   Technology Program Foundation of Zhejiang Province (2020KY843,
   2015KYB342), and Hwa Mei Foundation (2019HMKY10).
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NR 34
TC 4
Z9 7
U1 2
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD APR 14
PY 2021
VL 16
IS 1
AR 258
DI 10.1186/s13018-021-02405-6
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA RN6ZJ
UT WOS:000640500700003
PM 33853638
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ye, RT
   Ni, L
   Cheng, QY
AF Ye, Rentong
   Ni, Liang
   Cheng, Qianyu
TI Evaluation of the Efficacy of Vacuum Sealing Drainage in Combination
   With Silver-Containing Dressings for the Improvement of Chronic
   Refractory Wounds
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE Vacuum Sealing Drainage; Silver-Containing Dressing; Chronic Refractory
   Wound; Treatment Efficacy; Inflammatory State
ID PLATELET-RICH FIBRIN; THERAPY
AB Purpose: The aim of this study was to explore the clinical efficacy of vacuum sealing drainage in combination with silver-containing dressings for the treatment of chronic refractory wounds. Methods: In this retrospective study, 80 patients with chronic refractory wounds who were treated in the hospital were retrospectively selected as the study objects. Based on the treatment modalities, the patients were divided into the study group (SG; n=40, receiving vacuum sealing drainage combined with silver-containing dressings) and the control group (CG; n = 40, receiving vacuum sealing drainage alone). Results: The total effective rate of the SG was 92.5%, significantly higher than the 75% in the CG. After treatment, the SG exhibited lower positive rates in bacterial culture, as well as decreased levels of C-reactive protein and erythrocyte sedimentation rate compared to the CG. Starting from the sixth day of treatment, the SG reported statistically significant lower pain intensity scores than the CG. Additionally, the SG exhibited significantly lower dimension scores in terms of scar thickness, color, tenderness, and vascular distribution compared to the CG. Conclusion: The combined application of vacuum sealing drainage and silver-containing dressings demonstrated a positive treatment efficacy for patients with chronic refractory wounds.
C1 [Ye, Rentong; Ni, Liang; Cheng, Qianyu] Lanxi Peoples Hosp, Dept Plast Burn & Wound Repair, 1359 Xishan Rd, Jinhua 321100, Zhejiang, Peoples R China.
RP Cheng, QY (通讯作者)，Lanxi Peoples Hosp, Dept Plast Burn & Wound Repair, 1359 Xishan Rd, Jinhua 321100, Zhejiang, Peoples R China.
EM Chengqianyu2023@163.com
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   Xue X, 2022, FRONT BIOENG BIOTECH, V10, DOI 10.3389/fbioe.2022.979834
   Yan CQ, 2022, DRUG DELIV, V29, P214, DOI 10.1080/10717544.2021.2023699
   Yang JY, 2020, INT J NANOMED, V15, P5911, DOI 10.2147/IJN.S249129
   Zeng S D, 2023, Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, V39, P75, DOI 10.3760/cma.j.cn501225-20220216-00030
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NR 26
TC 2
Z9 2
U1 1
U2 8
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2024
VL 70
IS 3
AR 23067
DI 10.25270/wmp.23067
PG 11
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J1O0T
UT WOS:001334822500005
PM 39361340
DA 2026-07-24
ER

PT J
AU Lin, DZ
   Kao, YC
   Chen, CH
   Wang, HJ
   Chiu, WK
AF Lin, Dai-Zhu
   Kao, Yu-Chien
   Chen, Chiehfeng
   Wang, Hsian-Jenn
   Chiu, Wen-Kuan
TI Negative pressure wound therapy for burn patients: A meta-analysis and
   systematic review
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; DERMAL SUBSTITUTION;
   RECONSTRUCTIVE SURGERY; MANAGEMENT; EFFICACY
AB Negative pressure wound therapy (NPWT), which has been applied in various medical specialties to accelerate wound healing, has been the object of a few investigations. We explored the effectiveness of NPWT and the possibility of its inclusion in burn management guidelines. Randomised controlled trials comparing NPWT with non-NPWT treatments for burn wounds were extracted from PubMed. For the risk of bias analysis, all included studies were evaluated according to the Cochrane risk of bias tool and the approaches outlined in the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) Handbook. Outcomes such as graft take rate in the first week, infection rate, and overall complication rate were analysed. Six studies that included a total of 701 patients met our inclusion criteria. Qualitative analysis revealed that the NPWT group had a significantly better overall graft rate in the first week (P = 0.001) and a significantly lower infection rate (P = 0.04). No significant difference in the overall complication rate was found. Our results indicate that NPWT is a safe method for stimulating healing and lowering the infection rate of burn wounds. NPWT can be part of general burn management, and its incorporation into burn treatment guidelines is recommended.
C1 [Lin, Dai-Zhu; Kao, Yu-Chien] Taipei Med Univ, Coll Med, Taipei, Taiwan.
   [Chen, Chiehfeng; Wang, Hsian-Jenn; Chiu, Wen-Kuan] Taipei Med Univ, Taipei Municipal Wanfang Hosp, Div Plast Surg, Dept Surg, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Dept Publ Hlth, Taipei, Taiwan.
   [Chen, Chiehfeng] Taipei Med Univ, Cochrane Taiwan, Taipei, Taiwan.
   [Chiu, Wen-Kuan] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Municipal
   WanFang Hospital; Taipei Medical University; Taipei Medical University;
   Taipei Medical University
RP Chen, CH; Chiu, WK (通讯作者)，Taipei Med Univ, Div Plast Surg, Dept Surg, Wan Fang Hosp,Sch Med,Coll Med, 111 Xinglong Rd,Sec 3, Taipei 11696, Taiwan.
EM clifchen@tmu.edu.tw; doc20463@gmail.com
OI Chen, Chiehfeng/0000-0002-1595-6553
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NR 60
TC 25
Z9 27
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2021
VL 18
IS 1
BP 112
EP 123
DI 10.1111/iwj.13500
EA NOV 2020
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QE1EZ
UT WOS:000592097500001
PM 33236845
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Fagerdahl, AM
   Boström, L
   Ulfvarson, J
   Ottosson, C
AF Fagerdahl, Ann-Mari
   Bostrom, Lennart
   Ulfvarson, Johanna
   Ottosson, Carin
TI Risk Factors for Unsuccessful Treatment and Complications With Negative
   Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE
AB The aim of this retrospective study was to identify risk factors related to unsuccessful treatment and complications with negative pressure wound therapy (NPWT). Methods. A consecutive series of patients treated with NPWT for wounds of various etiologies (n = 87) from 2005-2007 at a general hospital in a large city (Stockholm, Sweden) were assessed for risk for unsuccessful treatment and complications associated with NPWT. Results. Twenty-nine percent of the patients treated with NPWT had unsuccessful treatment results. The strongest risk factors associated with unsuccessful treatment were pressure ulcers (OR 4.6) or a positive culture for Staphylococci (OR 3.4). The complication rate was 21%, of which 14 patients had to terminate treatment. A positive culture for either Staphylococci or Pseudomonas was strongly associated (P = 0.001) with risk of complications during NPWT treatment. Patients with insufficient peripheral circulation in the extremities had a risk of both unsuccessful treatment and complications. Conclusion. The findings of the present study stress the importance of evaluating bacterial cultures and adequate antibiotic therapy when infection is suspected. The status of the patient's peripheral macrocirculation in the lower extremities seems to have a significant impact on the risk of unsuccessful treatment or complications. There, fore, is it of great importance to evaluate peripheral circulation status before initializing NPWT.
C1 [Fagerdahl, Ann-Mari; Bostrom, Lennart; Ottosson, Carin] Karolinska Inst, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.
   [Ulfvarson, Johanna] Karolinska Inst, Dept Neurobiol Care Sci & Soc, S-11883 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet
RP Fagerdahl, AM (通讯作者)，Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.
EM ann-mari.fagerdahl@sodersjukhuset.se
OI Fagerdahl, Ami/0000-0002-9170-581X
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NR 28
TC 15
Z9 17
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUN
PY 2012
VL 24
IS 6
BP 168
EP 177
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 971HT
UT WOS:000306195500006
PM 25874465
DA 2026-07-24
ER

PT J
AU Kakagia, DD
   Georgiadis, G
   Drosos, G
AF Kakagia, Despoina D.
   Georgiadis, George
   Drosos, George
TI Dermal Matrices: Game Changers in Leg and Foot Soft Tissue
   Reconstruction? A Case Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE dermal matrix; degloving; leg reconstruction; foot reconstruction;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB The present article aims to present the use of dermal matrices in severe degloving, avulsion, and necrotizing injuries of the leg and foot in 3 patients. Conventional reconstruction would require the use of free flaps, since exposure of vessels, nerves, joints, and tendons rendered the mere resurfacing with skin grafts insufficient, and extensive cutaneous detachment precluded the use of local fasciocutaneous flaps. All injuries underwent thorough and repeated surgical debridements and wash outs, followed by negative pressure wound therapy (NPWT). Once negative tissue cultures were obtained, the extremities were resurfaced with dermal matrix and immediately covered by split thickness skin grafts. NPWT on the grafted area for a week effectively secured the grafts on the recipient area. Complete healing was achieved in all grafted areas within 7 to 12 days. The function of joints and tendons as well as the quality of resurfacing at the weight bearing areas were tested and found satisfactory within a follow-up period of 5 to 15 months. The use of combined NPWT and dermal matrices in carefully selected patients provides a reliable and durable reconstructive option for leg and foot injuries with satisfactory functional outcomes.
C1 [Kakagia, Despoina D.; Georgiadis, George; Drosos, George] Democritus Univ Hosp, Alexandroupolis, Greece.
C3 Democritus University of Thrace; Democritus University Thrace Hospital
RP Kakagia, DD (通讯作者)，Democritus Univ Hosp, Dept Surg, Alexandroupolis 68100, Greece.
EM despoinakakagia@yahoo.com
RI Kakagia, Despoina/AAP-1202-2021
OI Kakagia, Despoina/0000-0003-2107-6170
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NR 22
TC 3
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2023
VL 22
IS 1
BP 56
EP 62
AR 1534734621990311
DI 10.1177/1534734621990311
EA JUN 2021
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8O4OX
UT WOS:000657903300001
PM 34060922
DA 2026-07-24
ER

PT J
AU Anglim, B
   O'Connor, H
   Daly, S
AF Anglim, B.
   O'Connor, H.
   Daly, S.
TI Prevena™, negative pressure wound therapy applied to closed Pfannenstiel
   incisions at time of caesarean section in patients deemed at high risk
   for wound infection
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE High-risk pregnancy; obesity in pregnancy; Prevena (TM) negative
   pressure wound therapy; wound infection
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT-SYSTEM; PREVENTION; EXPERIENCE;
   DELIVERY; SURGERY
AB The aim of our retrospective study is to report on our experience using the Prevena (TM) wound system in obese patients undergoing caesarean section delivery. A total of 26 cases were identified from July 2012 to October 2013. The median BMI of these women was 45.3 kg/m(2). Elective caesarean sections were performed in 20 women (77%). There were four cases (15%) of superficial dehiscence. Factors associated with wound breakdown were wound infection (p = 0.03), increasing BMI (p = 0.001) and emergency LSCS (p = 0.04). In a logistic regression model the presence of infection was the only factor which remained associated with wound breakdown. Wound disruption is a major cause of morbidity following caesarean section in morbidly obese patients. The wound complication rate in our experience was low with the Prevena (TM) dressing with no cases of sheath dehiscence, and no patient required a second operation. The presence of infection is the most important factor in wound breakdown and should be the focus for management protocols.
C1 [Anglim, B.; O'Connor, H.; Daly, S.] Coombe Women & Infants Univ Hosp, Dept Obstet & Gynaecol, Dublin 8, Ireland.
RP Anglim, B (通讯作者)，Coombe Women & Infants Univ Hosp, Dept Obstet & Gynaecol, Dublin 8, Ireland.
EM breffini.anglim@gmail.com
RI ; O'Connor, Hannah/JBJ-1868-2023
OI Daly, Sean/0009-0001-8450-8113; 
CR Alanis MC, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.06.049
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   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
NR 21
TC 17
Z9 20
U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0144-3615
EI 1364-6893
J9 J OBSTET GYNAECOL
JI J. Obstet. Gynaecol.
PD APR
PY 2015
VL 35
IS 3
BP 255
EP 258
DI 10.3109/01443615.2014.958442
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CH3IP
UT WOS:000353924500008
PM 25383909
DA 2026-07-24
ER

PT J
AU Borejsza-Wysocki, M
   Szmyt, K
   Bobkiewicz, A
   Malinger, S
   Swirkowicz, J
   Hermann, J
   Drews, M
   Banasiewicz, T
AF Borejsza-Wysocki, Maciej
   Szmyt, Krzysztof
   Bobkiewicz, Adam
   Malinger, Stanislaw
   Swirkowicz, Jozef
   Hermann, Jacek
   Drews, Michal
   Banasiewicz, Tomasz
TI Endoscopic vacuum-assisted closure system (E-VAC): case report and
   review of the literature
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Review
DE endoscopic vacuum-assisted wound closure system; Endo-Sponge;
   vacuum-assisted wound closure therapy; eosophageal leakage; rectal
   anastomotic leakage; pancreatico-gastric anastomotic insufficiency
ID ENDO-SPONGE TREATMENT; ANASTOMOTIC LEAKAGE; RISK-FACTORS; ESOPHAGEAL
   LEAKAGE; RECTAL RESECTION; THERAPY; DRAINAGE; SURGERY; PERFORATIONS;
   INSUFFICIENCY
AB Negative pressure wound therapy (NPWT) has become a standard in the treatment of chronic and difficult healing wounds. Negative pressure wound therapy is applied to the wound via a special vacuum-sealed sponge. Nowadays, the endoscopic vacuum-assisted wound closure system (E-VAC) has been proven to be an important alternative in patients with upper and lower intestinal leakage not responding to standard endoscopic and/or surgical treatment procedures. Endoscopic vacuum-assisted wound closure system provides perfect wound drainage and closure of various kinds of defect and promotes tissue granulation. Our experience has shown that E-VAC may significantly improve the morbidity and mortality rate. Moreover, E-VAC may be useful in a multidisciplinary approach from upper gastrointestinal to rectal surgery complications. On the other hand, major limitations of the E-VAC system are the necessity of repeated endoscopic interventions and constant presence of well-trained staff Further, large-cohort studies need to be performed to establish the applicability and effectiveness of E-VAC before routine widespread use can be recommended.
C1 [Borejsza-Wysocki, Maciej; Szmyt, Krzysztof; Bobkiewicz, Adam; Malinger, Stanislaw; Swirkowicz, Jozef; Hermann, Jacek; Drews, Michal; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastrointestinal Onco, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Szmyt, K (通讯作者)，Poznan Univ Med Sci, Dept Gen & Endocrine Surg & Gastrointestinal Onco, 49 Przybyszewskiego St, PL-60355 Poznan, Poland.
EM krzysztof.szmyt@gmail.com
OI Bobkiewicz, Adam/0000-0002-4657-5788
CR Ahrens M, 2010, ENDOSCOPY, V42, P693, DOI 10.1055/s-0030-1255688
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   Gubler C, 2013, DIS ESOPHAGUS, V26, P598, DOI 10.1111/dote.12005
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   Rosenberger LH, 2014, CTS-CLIN TRANSL SCI, V7, P121, DOI 10.1111/cts.12140
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NR 51
TC 15
Z9 24
U1 0
U2 6
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2015
VL 10
IS 2
BP 299
EP 310
DI 10.5114/wiitm.2015.52080
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CM8RB
UT WOS:000357968200023
PM 26240633
DA 2026-07-24
ER

PT J
AU Ludolph, I
   Fried, FW
   Kneppe, K
   Arkudas, A
   Schmitz, M
   Horch, RE
AF Ludolph, Ingo
   Fried, Frederik W.
   Kneppe, Katharina
   Arkudas, Andreas
   Schmitz, Marweh
   Horch, Raymund E.
TI Negative pressure wound treatment with computer-controlled
   irrigation/instillation decreases bacterial load in contaminated wounds
   and facilitates wound closure
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bacterial load; contaminated wounds; instillation; negative pressure
   wound therapy
ID VACUUM-ASSISTED CLOSURE; THERAPY; INSTILLATION; RECOMMENDATIONS;
   PROLOGUE; SALVAGE
AB Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer-controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 patients, a minimum of 4 operative procedures were necessary, and swabs were taken at least at the first and at the fourth operation in a standardised procedure. The number of different bacteria and the amount of bacteria were analysed during the course. In a subgroup of 51 patients, swabs were taken at all 4 operative procedures and analysed separately. In an overall analysis, the number of different bacteria and the amount of bacteria significantly decreased independent of wound localisation and diagnosis. NPWT with automated instillation demonstrates a positive influence in the reduction of bacterial load in problem wounds. Thus, it may help to optimise wound conditions before definite wound closure.
C1 Friedrich Alexander Univ Erlangen Nuernberg FAU, Univ Hosp Erlangen, Dept Plast & Hand Surg, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuernberg FAU, Univ Hosp Erlangen, Lab Tissue Engn & Regenerat Med, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Ludolph, I (通讯作者)，Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ingo.ludolph@uk-erlangen.de
RI Horch, Raymund/H-8128-2019; Arkudas, Andreas/AAQ-6745-2021
OI Arkudas, Andreas/0000-0002-2473-5816
CR Back DA, 2013, INT WOUND J, V10, P32, DOI 10.1111/iwj.12183
   Bessa LJ, 2015, INT WOUND J, V12, P47, DOI 10.1111/iwj.12049
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   Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
   Deleyto E, 2018, HERNIA, V22, P311, DOI 10.1007/s10029-017-1691-y
   Dragu A, 2011, OBES SURG, V21, P1781, DOI 10.1007/s11695-010-0328-3
   Falagas ME, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064741
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   Gabriel Allen, 2014, Eplasty, V14, pe41
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   Horch RE, 2008, CHIRURG, V79, P518, DOI 10.1007/s00104-008-1500-3
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   Kirsner RS, 2016, INT WOUND J, V13, P5, DOI 10.1111/iwj.12633
   Koncar I, 2016, VOJNOSANIT PREGL, V73, P9, DOI 10.2298/VSP13122212K
   Leffler M, 2011, J CELL MOL MED, V15, P1564, DOI 10.1111/j.1582-4934.2010.01147.x
   Lehner B, 2011, INT ORTHOP, V35, P1415, DOI 10.1007/s00264-011-1274-y
   Lessing MC, 2013, EPLASTY, V13, pe51
   Ludolph I, 2018, HANDCHIR MIKROCHIR P, V50, P118, DOI 10.1055/s-0043-115730
   Matiasek J, 2017, J WOUND CARE, V26, P236, DOI 10.12968/jowc.2017.26.5.236
   Meybodi F, 2017, ANZ J SURG, V87, pE293, DOI 10.1111/ans.13379
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Raad W, 2010, INT WOUND J, V7, P81, DOI 10.1111/j.1742-481X.2010.00658.x
   Schintler MV, 2012, DIABETES-METAB RES, V28, P72, DOI 10.1002/dmrr.2243
   Singh D, 2017, WOUNDS, V29, P175
   Téot L, 2017, INT WOUND J, V14, P842, DOI 10.1111/iwj.12719
   Willy C, 2004, ZBL CHIR, V129, pS6
   Willy C, 2013, INT WOUND J, V10, P1, DOI 10.1111/iwj.12177
   Yao M, 2014, INT WOUND J, V11, P483, DOI 10.1111/j.1742-481X.2012.01113.x
NR 33
TC 45
Z9 55
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2018
VL 15
IS 6
BP 978
EP 984
DI 10.1111/iwj.12958
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GZ7ES
UT WOS:000449641000016
PM 29974664
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Wagstaff, MJD
   Driver, S
   Coghlan, P
   Greenwood, JE
AF Wagstaff, Marcus James Dermot
   Driver, Sara
   Coghlan, Patrick
   Greenwood, John Edward
TI A randomized, controlled trial of negative pressure wound therapy of
   pressure ulcers via a novel polyurethane foam
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DERMAL MATRIX; POLYMER; SKIN
AB The objectives of the study were (1) to look for any local, clinically apparent response, within and around a debrided wound, to a novel biocompatible polyurethane foam during repeated, short-term implantation, and (2) to assess the material's efficacy as a negative pressure wound therapy (NPWT) interface compared with a widely used, commercially available foam. Twenty pressure ulcers in 18 patients underwent surgical debridement, then randomization to receive novel treatment or control foam as the wound interface for NPWT. Dressing changes every 2-3 days allowed qualitative wound assessment and quantitative measurement to compare outcomes. No adverse reaction was observed in any patient receiving the new foam. The new novel foam performed as a NPWT interface as effectively as the control standard foam. In deep wounds, the new foam was easier to remove, fragmented less, and showed less retention than the control foam. No marginal in-growth occurred, making removal less traumatic and reducing bleeding from cavity wall granulations. The results support previous large animal studies, and independent ISO10993 testing, that the new foam is safe and biocompatible. Its efficacy as an NPWT interface, nontraumatic removal with low fragmentation and retention rate, favors the new material, especially in deep cavity wounds.
C1 [Wagstaff, Marcus James Dermot] Royal Adelaide Hosp, Dept Plast & Reconstruct Surg, Adelaide, SA 5000, Australia.
   [Coghlan, Patrick; Greenwood, John Edward] Royal Adelaide Hosp, Adult Burn Ctr, Adelaide, SA 5000, Australia.
   [Driver, Sara] Royal Dist Nursing Serv, Adelaide, SA, Australia.
C3 Royal Adelaide Hospital; Royal Adelaide Hospital
RP Greenwood, JE (通讯作者)，Royal Adelaide Hosp, Adult Burn Ctr, N Terrace, Adelaide, SA 5000, Australia.
EM john.greenwood@health.sa.gov.au
OI Wagstaff, Marcus/0000-0003-3160-3720
FU PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia
FX Funding for this study was provided by PolyNovo Biomaterials Pty Ltd,
   Port Melbourne, Victoria, Australia, who provided the treatment
   materials (NovoPore) and paid the RDNS to backfill the position of the
   study nurse. By virtue of the gratis supply of pumps, dressings and
   control foam, Kinetic Concepts Incorporated, San Antonio, Texas,
   additionally supported the trial.
CR [Anonymous], 2009, FDA PREL PUBL HLTH N
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dearman BL, 2013, J BURN CARE RES, V34, P151, DOI 10.1097/BCR.0b013e31828089f9
   FDA Safety Communication, 2011, UPDATE SER COMPL ASS
   Greenwood JE, 2010, WOUND PRACT RES, V18, P14
   Greenwood JE, 2010, WOUND PRACT RES, V18, P24
   Greenwood JE, 2012, J BURN CARE RES, V33, P7, DOI 10.1097/BCR.0b013e3182372be9
   Greenwood JE, 2012, J BURN CARE RES, V33, P163, DOI 10.1097/BCR.0b013e318233fac1
   Li A, 2009, J BURN CARE RES, V30, P717, DOI 10.1097/BCR.0b013e3181abffca
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
NR 10
TC 32
Z9 41
U1 0
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR
PY 2014
VL 22
IS 2
BP 205
EP 211
DI 10.1111/wrr.12146
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AC9DV
UT WOS:000332835400188
PM 24635170
DA 2026-07-24
ER

PT J
AU DeCarbo, WT
   Hyer, CF
AF DeCarbo, William T.
   Hyer, Christopher F.
TI Negative-pressure Wound Therapy Applied to High-risk Surgical Incisions
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE calcaneus; fracture; healing; surgery; total ankle replacement; vacuum
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TRAUMA
AB Negative-pressure wound therapy (NPWT) is commonly used for chronic wounds, open fractures with soft tissue defects, and coverage over split-thickness skin grafts. NPWT uniformly draws wounds closed by helping to remove interstitial fluid, which contains inflammatory and potentially infectious exudate that could impair healing. Recently in our practice, we have used NPWT in cases involving tenuous incisions, such as those used to access target structures during total ankle replacement or open repair of joint depression calcaneal fractures, in an effort to prevent hematoma or wound dehiscence. Although it is generally understood that NPWT can be efficacious and cost-effective for management of a wide range of lower extremity wounds, we also believe it to be beneficial in the management of low-energy trauma and elective hindfoot and ankle reconstructions, and feel that it has led to decreased pain, swelling, and time to healing in our patients. Based on our experience with ankle arthroplasty and the surgical management of hindfoot and ankle trauma, we believe that the use of NWPT in the immediate postoperative period is both safe and efficacious. (C) 2010 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [DeCarbo, William T.; Hyer, Christopher F.] Orthoped Foot & Ankle Ctr, Westerville, OH 43082 USA.
RP DeCarbo, WT (通讯作者)，Orthoped Foot & Ankle Ctr, 300 Polaris Pkwy,Suite 2000, Westerville, OH 43082 USA.
EM ofacresearch@orthofootankle.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   DeFranzo AJ, 2001, PLAST RECONSTR SURG, V108, P1184, DOI 10.1097/00006534-200110000-00013
   Flack S, 2008, J Wound Care, V17, P71
   Herscovici D, 2003, J ORTHOP TRAUMA, V17, P683, DOI 10.1097/00005131-200311000-00004
   Hunter Judith E, 2007, Int Wound J, V4, P256, DOI 10.1111/j.1742-481X.2007.00361.x
   Parrett BM, 2006, PLAST RECONSTR SURG, V117, P1315, DOI 10.1097/01.prs.0000204959.18136.36
   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Weinberg Group Inc, 1999, TECHN ASS V A C IN H, P61
NR 8
TC 47
Z9 56
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD MAY-JUN
PY 2010
VL 49
IS 3
BP 299
EP 300
DI 10.1053/j.jfas.2010.01.002
PG 2
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 593RZ
UT WOS:000277479500013
PM 20605565
DA 2026-07-24
ER

PT J
AU Armstrong, DG
   Marston, WA
   Reyzelman, AM
   Kirsner, RS
AF Armstrong, David G.
   Marston, William A.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI Comparative effectiveness of mechanically and electrically powered
   negative pressure wound therapy devices: A multicenter randomized
   controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; GAUZE; CARE;
   TRANSDUCTION; SYSTEM; STATE; FOAM
AB This study was designed to compare the ultraportable mechanically powered Smart Negative Pressure (SNaP) Wound Care System (Spiracur, Sunnyvale, CA) with the electrically powered Vacuum-Assisted Closure (VAC) Therapy System (Kinetic Concepts, Inc. [KCI], San Antonio, TX) in a multicenter, comparative efficacy, noninferiority-powered, randomized controlled trial. We enrolled 132 people with noninfected, nonischemic, nonplantar lower extremity diabetic and venous wounds. Each subject was randomly assigned (1:1) to treatment with either system in conjunction with appropriate off-loading and compression therapy. The trial evaluated treatment for up to 16 weeks or complete wound closure (defined as complete reepithelialization without drainage). Primary end point analysis of wound size reduction found that SNaP-treated subjects demonstrated noninferiority to the VAC-treated subjects at 4, 8, 12, and 16 weeks (p?=?0.0030, 0.0130, 0.0051, and 0.0044, respectively). KaplanMeier analysis showed no significant difference in complete wound closure between SNaP- and VAC-treated subjects at all time points. Device related adverse events and complications such as infection were also similar between treatment groups. These data support similar wound healing outcomes between the SNaP system and the VAC system in the population studied.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, So Arizona Limb Salvage Alliance SALSA, Tucson, AZ 85724 USA.
   [Marston, William A.] Univ N Carolina, Sch Med, Dept Surg, Div Vasc Surg, Chapel Hill, NC USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Dept Med, Calif Sch Podiatr Med, Oakland, CA USA.
   [Kirsner, Robert S.] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
C3 University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   Samuel Merritt University; University of Miami
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, So Arizona Limb Salvage Alliance SALSA, 1501 N Campbell Ave,POB 245072, Tucson, AZ 85724 USA.
EM armstrong@usa.net
FU Spiracur, Inc.; KCI
FX This study was sponsored by a grant from Spiracur, Inc. Two authors (DGA
   and WAM) have received research funding from both Spiracur, Inc. and
   KCI.
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NR 27
TC 54
Z9 63
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2012
VL 20
IS 3
BP 332
EP 341
DI 10.1111/j.1524-475X.2012.00780.x
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 936NY
UT WOS:000303598500008
PM 22564228
DA 2026-07-24
ER

PT J
AU Cherubino, M
   Valdatta, L
   Tos, P
   D'Arpa, S
   Troisi, L
   Igor, P
   Corradi, F
   Khan, U
AF Cherubino, Mario
   Valdatta, Luigi
   Tos, Pierluigi
   D'Arpa, Salvatore
   Troisi, Luigi
   Igor, Pellegatta
   Corradi, Federica
   Khan, Umraz
TI Role of Negative Pressure Therapy as Damage Control in Soft Tissue
   Reconstruction for Open Tibial Fractures
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article
DE damage control; negative pressure wound therapy; limb trauma; soft
   tissue; microsurgical reconstruction
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; WOUND THERAPY; VASCULAR
   INJURIES; MANAGEMENT; COVERAGE; FLAP; SALVAGE
AB The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed. A negative-pressure dressing can be easily and rapidly applied to obtain a temporary closure between surgical stages. While negative pressure wound therapy (NPWT) has clear indications in the management of chronic wounds, its applications in the acute setting in victims of polytrauma are uneven. We conducted a review of the current clinical literature to evaluate the role of NPWT in this field, which points out that the negative pressure, applied immediately after the first debridement, seems to be an optimal bridge to the final reconstruction up to 7 days.
C1 [Cherubino, Mario; Valdatta, Luigi; Igor, Pellegatta; Corradi, Federica] Univ Insubria, Div Plast & Reconstruct Surg, Dept Biotechnol & Life Sci, Varese, Italy.
   [Tos, Pierluigi] ASST Gaetano Pini, Dept Orthopaed & Traumatol Hand, Milan, Italy.
   [D'Arpa, Salvatore] Ghent Univ Hosp, Dept Plast & Reconstruct Surg, Ghent, Belgium.
   [D'Arpa, Salvatore] Univ Palermo, Div Plast & Reconstruct Surg, Dept Surg Oncol & Oral Sci, Palermo, Italy.
   [Troisi, Luigi; Khan, Umraz] North Bristol NHS Trust, Southmead Hosp, Dept Plast & Reconstruct Surg, Bristol, Avon, England.
C3 University of Insubria; ASST Gaetano Pini CTO; Ghent University; Ghent
   University Hospital; University of Palermo; North Bristol NHS Trust;
   Southmead Hospital
RP Cherubino, M (通讯作者)，Univ Insubria, Div Plast & Reconstruct Surg, ASST Sette Laghi, Dept Biotechnol & Life Sci, Viale Borri 57, I-21100 Verese, VA, Italy.
EM mario.cherubino@gmail.com
RI tos, pierluigi/R-5803-2016; Cherubino, Mario/N-1780-2019; Troisi,
   Luigi/AAA-6179-2022
OI tos, pierluigi/0000-0002-1349-7082; Cherubino,
   Mario/0000-0003-1196-3075; Troisi, Luigi/0000-0002-4754-3075
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
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   Breugem Corstiaan C, 2006, Int J Low Extrem Wounds, V5, P261, DOI 10.1177/1534734606295030
   BYRD HS, 1985, PLAST RECONSTR SURG, V76, P719, DOI 10.1097/00006534-198511000-00011
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NR 33
TC 21
Z9 28
U1 0
U2 10
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD OCT
PY 2017
VL 33
SU 1
BP S8
EP S13
DI 10.1055/s-0037-1606542
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FJ1YG
UT WOS:000412516600003
PM 28985633
DA 2026-07-24
ER

PT J
AU Marais, LC
   Hungerer, S
   Eckardt, H
   Zalavras, C
   Obremskey, WT
   Ramsden, A
   Mcnally, MA
   Morgenstern, M
   Metsemakers, WJ
AF Marais, Leonard C.
   Hungerer, Sven
   Eckardt, Henrik
   Zalavras, Charalampos
   Obremskey, William T.
   Ramsden, Alex
   Mcnally, Martin A.
   Morgenstern, Mario
   Metsemakers, Willem-Jan
CA FRI Consensus Grp
TI Key aspects of soft tissue management in fracture-related infection:
   recommendations from an international expert group
SO ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
LA English
DT Review; Early Access
DE Fracture-related infection; Soft tissue closure; Soft tissue cover; Soft
   tissue defects, flap; Negative pressure wound therapy; Fasciocutaneous
   flap; Muscle flap; Fracture; Infection
ID PRESSURE WOUND THERAPY; OPEN TIBIAL FRACTURES; VACUUM-ASSISTED CLOSURE;
   MUSCLE FLAP COVERAGE; LOWER-LIMB; CHRONIC OSTEOMYELITIS; INITIAL
   MANAGEMENT; TRAUMATIC WOUNDS; BACTERIAL LOAD; BLOOD-FLOW
AB A judicious, well-planned bone and soft tissue debridement remains one of the cornerstones of state-of-the-art treatment of fracture-related infection (FRI). Meticulous surgical excision of all non-viable tissue can, however, lead to the creation of large soft tissue defects. The management of these defects is complex and numerous factors need to be considered when selecting the most appropriate approach. This narrative review summarizes the current evidence with respect to soft tissue management in patients diagnosed with FRI. Specifically we discuss the optimal timing for tissue closure following debridement in cases of FRI, the need for negative microbiological culture results from the surgical site as a prerequisite for definitive wound closure, the optimal type of flap in case of large soft tissue defects caused by FRI and the role of negative pressure wound therapy (NPWT) in FRI. Finally, recommendations are made with regard to soft tissue management in FRI that should be useful for clinicians in daily clinical practice.
C1 [Marais, Leonard C.] Univ KwaZulu Natal, Sch Clin Med, Dept Orthopaed, Durban, South Africa.
   [Hungerer, Sven] Murnau Germany & Paracelsus Med Univ PMU Salzburg, Trauma Ctr Murnau, Dept Joint Surg & Arthroplasty, Salzburg, Austria.
   [Eckardt, Henrik; Morgenstern, Mario] Univ Hosp Basel, Dept Orthopaed & Trauma Surg, Basel, Switzerland.
   [Zalavras, Charalampos] Univ Southern Calif, Keck Sch Med, Dept Orthopaed Surg, Los Angeles, CA USA.
   [Obremskey, William T.] Vanderbilt Univ Sch Med, Dept Orthopaed Surg & Rehabil, Nashville, TN USA.
   [Ramsden, Alex; Mcnally, Martin A.] Oxford Univ Hosp, Nuffield Orthopaed Ctr, Bone Infect Unit, Oxford, England.
   [Metsemakers, Willem-Jan] Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
C3 University of Kwazulu Natal; University of Basel; University of Southern
   California; Vanderbilt University; Nuffield Orthopaedic Centre; KU
   Leuven; University Hospital Leuven
RP Metsemakers, WJ (通讯作者)，Univ Hosp Leuven, Dept Trauma Surg, Leuven, Belgium.
EM willem-jan.metsemakers@uzleuven.be
RI Hungerer, Sven/H-5818-2013; Metsemakers, Willem-Jan/F-8647-2016;
   Morgenstern, Mario/AAL-8268-2020; Marais, Leonard Charles/AIC-4689-2022;
   Obremskey, William/HRA-4704-2023
OI Eckardt, Henrik/0000-0001-5842-7603; Metsemakers,
   Willem-Jan/0000-0002-4114-9093; Morgenstern, Mario/0000-0001-5108-0731; 
FU <bold>Members of the FRI consensus group:</bold> Willem-Jan Metsemakers,
   Department of Trauma Surgery, University Hospitals Leuven, Leuven,
   Belgium. William T. Obremskey, Department of Orthopaedic Surgery and
   Rehabilitation, Vanderbilt University Medical C; University Hospitals
   Leuven, Leuven, Belgium; Department of Orthopaedic Surgery and
   Rehabilitation; Vanderbilt University Medical Center, Nashville, TN,
   United States of America; Bone Infection Unit, Nuffield Orthopaedic
   Centre, Oxford University Hospitals, Oxford, United Kingdom; CHUV,
   Lausanne, Switzerland; Department of Laboratory Medicine, University
   Hospitals Leuven, Belgium; Department of Orthopaedic and Trauma Surgery,
   University Hospital Basel, Switzerland; NYU Langone Orthopedic Hospital,
   New York, NY, USA; Limb Lengthening amp; Complex Reconstruction Service,
   New York, NY, USA; University of Utrecht, University Medical Center
   Utrecht, Utrecht, The Netherlands; Paracelsus Medical University (PMU)
   Salzburg, Austria; Virginia Commonwealth University, USA; Richard Kuehl,
   Department of Infectious Diseases and Hospital Epidemiology, University
   Hospital of Basel, Switzerland; Department of Orthopaedics, School of
   Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa;
   Department of Orthopaedic Surgery, University Hospitals of North
   Midlands, Stoke-on-Trent, United Kingdom; Mario Morgenstern, Department
   of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland; AO Research Institute Davos, Switzerland; Department of
   Orthopaedic Surgery, Keck School of Medicine, University of Southern
   California, Los Angeles, USA; Gustave Dron Hospital, University of
   Lille, France; Berlin Institute of Health, Germany; Erasmus University
   Medical Centre, Rotterdam, The Netherlands; Interdisciplinary Unit for
   Orthopedic Infections, Kantonsspital Baselland
FX The source of funding with respect to hosting the consensus meeting 2018
   was the AO Foundation (AOTC System and AOTrauma). Travel costs for the
   Orthopaedic Trauma Association members were met by the Orthopaedic
   Trauma Association. Open access publication was funded by the AO
   Foundation.r <BOLD>Members of the FRI consensus group:</BOLD> Willem-Jan
   Metsemakers, Department of Trauma Surgery, University Hospitals Leuven,
   Leuven, Belgium. William T. Obremskey, Department of Orthopaedic Surgery
   and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN,
   United States of America. Martin A. McNally, The Bone Infection Unit,
   Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United
   Kingdom. Bridget L. Atkins, The Bone Infection Unit, Nuffield
   Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom.
   Olivier Borens, Orthopedic Department of Septic Surgery,
   Orthopaedic-Trauma Unit, Department for the Musculoskeletal System,
   CHUV, Lausanne, Switzerland. Melissa Depypere, Department of Laboratory
   Medicine, University Hospitals Leuven, Belgium. Henrik Eckardt,
   Department of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland. Kenneth A. Egol, Department of Orthopedic Surgery, NYU
   Langone Orthopedic Hospital, New York, NY, USA. Austin T. Fragomen,
   Hospital for Special Surgery, Limb Lengthening & Complex Reconstruction
   Service, New York, NY, USA. Jolien Onsea, Department of Trauma Surgery,
   University Hospitals Leuven, Leuven, Belgium. Geertje A. M. Govaert,
   Department of Trauma Surgery, University of Utrecht, University Medical
   Center Utrecht, Utrecht, The Netherlands. Sven Hungerer, Department of
   Joint Surgery and Arthroplasty, Trauma Center Murnau, Murnau Germany and
   Paracelsus Medical University (PMU) Salzburg, Austria. Stephen L. Kates,
   Department of Orthopaedic Surgery, Virginia Commonwealth University,
   USA. Richard Kuehl, Department of Infectious Diseases and Hospital
   Epidemiology, University Hospital of Basel, Switzerland. Leonard C.
   Marais, Department of Orthopaedics, School of Clinical Medicine,
   University of KwaZulu-Natal, Durban, South Africa. Ian Mcfadyen,
   Department of Orthopaedic Surgery, University Hospitals of North
   Midlands, Stoke-on-Trent, United Kingdom. Mario Morgenstern, Department
   of Orthopaedic and Trauma Surgery, University Hospital Basel,
   Switzerland. T. Fintan Moriarty, AO Research Institute Davos,
   Switzerland. Alex Ramsden, The Bone Infection Unit, Nuffield Orthopaedic
   Centre, Oxford University Hospitals, Oxford, United Kingdom. Michael
   Raschke, Department of Trauma Surgery, University Hospital of Munster,
   Germany. R. Geoff Richards, AO Research Institute Davos, Switzerland.
   Carlos Sancineto, Department of Orthopaedics, Hospital Italiano de
   Buenos Aires, Buenos Aires, Argentina. Charalampos Zalavras, Department
   of Orthopaedic Surgery, Keck School of Medicine, University of Southern
   California, Los Angeles, USA. Eric Senneville, Department of Infectious
   Diseases, Gustave Dron Hospital, University of Lille, France. Andrej
   Trampuz, Center for Musculoskeletal Surgery, Charite-Universitatsmedizin
   Berlin, corporate member of Freie Universitat Berlin,
   Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Germany.
   Michael H. J. Verhofstad, Department of Trauma Surgery, Erasmus
   University Medical Centre, Rotterdam, The Netherlands. Werner Zimmerli,
   Interdisciplinary Unit for Orthopedic Infections, Kantonsspital
   Baselland, Rheinstrasse 26, 4410, Liestal, Switzerland.
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NR 77
TC 16
Z9 21
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0936-8051
EI 1434-3916
J9 ARCH ORTHOP TRAUM SU
JI Arch. Orthop. Trauma Surg.
PD 2023 NOV 3
PY 2023
DI 10.1007/s00402-023-05073-9
EA NOV 2023
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA EF7O4
UT WOS:001137575400002
PM 37921993
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Müller, CSL
   Burgard, B
   Zimmerman, M
   Vogt, T
   Pföhler, C
AF Mueller, Cornelia Sigrid Lissi
   Burgard, Barbara
   Zimmerman, Monika
   Vogt, Thomas
   Pfoehler, Claudia
TI On the significance of negative-pressure wound therapy with instillation
   in dermatology
SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; CHRONIC LEG ULCERS; INSTILL(R) THERAPY; SALINE
   INSTILLATION; TOPICAL TREATMENT; INFECTED WOUNDS; FIBRIN MATRIX; CASE
   SERIES; IN-VITRO; OSTEOMYELITIS
AB Methods used in the treatment of acute and chronic wounds undergo constant evolution, reevaluation, and innovation. While negative-pressure wound therapy (NPWT) is an established treatment modality, the combination of NPWT and instillation of normal saline as well as solutions with active antiseptic components for topical treatment of the wound bed represents a novel approach. The well-known effects of NPWT may thus be combined with those of local antisepsis. They include a decrease in wound area, induction of granulation tissue, and reduction in bacterial colonization. To date, studies have focused on NPWT with instillation for orthopedic/surgical indications, whereas clinical data in dermatosurgery is limited to case reports or small case series. There are as yet no randomized prospective studies investigating NPWT with instillation in the treatment of skin disorders. The goal of this review is to present the method of NPWT with instillation, to highlight its mode of action as well as possible complications and contraindications, and to review the recent literature. In summary, there is increasing evidence that both simple and complicated wounds may be effectively treated with NPWT with instillation, resulting in markedly accelerated tissue granulation and thus earlier defect closure.
C1 [Mueller, Cornelia Sigrid Lissi; Burgard, Barbara; Zimmerman, Monika; Vogt, Thomas; Pfoehler, Claudia] Univ Hosp Saarland, Dept Dermatol Allergol & Venereol, Kirrberger Str, D-66421 Homburg, Germany.
C3 Universitatsklinikum des Saarlandes
RP Müller, CSL (通讯作者)，Univ Hosp Saarland, Dept Dermatol Allergol & Venereol, Kirrberger Str, D-66421 Homburg, Germany.
EM cornelia.mueller@uks.eu
OI Müller, Cornelia/0000-0002-7656-721X
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NR 66
TC 5
Z9 8
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1610-0379
EI 1610-0387
J9 J DTSCH DERMATOL GES
JI J. Dtsch. Dermatol. Ges.
PD AUG
PY 2016
VL 14
IS 8
BP 786
EP 795
DI 10.1111/ddg.13038
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DY6XI
UT WOS:000385272200003
PM 27509412
OA Bronze
DA 2026-07-24
ER

PT J
AU Cemile, N
   Opara, P
   Ozturk, C
   Djohan, R
AF Ozturk, Cemile Nurdan
   Opara, Praise
   Ozturk, Can
   Djohan, Risal
TI Treatment of Foot Degloving Injury With Aid of Negative Pressure Wound
   Therapy and Dermal Regeneration Template
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE avulsion; fascia; lower extremity; skin; trauma; wound vacuum
ID VACUUM-ASSISTED CLOSURE; AVULSION INJURIES; SKIN-GRAFTS; RECONSTRUCTION;
   MANAGEMENT; INTEGRA; FLAP; SOLE; HEEL
AB Degloving injury of the foot continues to be a challenging condition to treat. Despite current advancements in reconstructive options, most of these injuries can result in amputations, causing physical and emotional impairment. Few reports have been published on the management of these complex traumatic injuries. Typical reconstruction options have included skin grafting and reattachment of the avulsed skin. Many treating physicians have encountered challenging issues in predicting tissue viability, knowing the extent of the injury, and making a logical decision for limb salvage procedures. The present report provides an algorithm of our approach in managing degloving injuries. A case of foot degloving injury, treated by serial surgical operations with the dominant aim of salvaging the avulsed tissue, is presented. The avulsed portion of the foot, with no identifiable vessels for microsurgical reattachment, was defatted and used as a full-thickness skin graft. Negative pressure wound therapy and a dermal regeneration template were used as adjunct techniques to help obtain good soft tissue coverage. The traditional treatment methods for degloving injuries and the applications of new wound care technologies are discussed. (C) 2015 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Ozturk, Cemile Nurdan; Ozturk, Can] Roswell Pk Canc Inst, Dept Head & Neck Surgery Plast & Reconstruct Surg, Buffalo, NY 14263 USA.
   [Djohan, Risal] Cleveland Clin, Inst Dermatol & Plast Surg, Dept Plast Surg, Cleveland, OH USA.
C3 Roswell Park Comprehensive Cancer Center; Cleveland Clinic Foundation
RP Cemile, N (通讯作者)，Roswell Pk Canc Inst, Dept Head & Neck Surgery Plast & Reconstruct Surg, Elm & Carlton St, Buffalo, NY 14263 USA.
EM cemile.ozturk@roswellpark.org
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NR 18
TC 8
Z9 11
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD NOV-DEC
PY 2015
VL 54
IS 6
BP 1132
EP 1135
DI 10.1053/j.jfas.2014.06.014
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA CU8WX
UT WOS:000363825900027
PM 26234924
DA 2026-07-24
ER

PT J
AU Chen, CY
   Kuo, SM
   Tarng, YW
   Lin, KC
AF Chen, Chun-Yu
   Kuo, Shyh-Ming
   Tarng, Yih-Wen
   Lin, Kai-Cheng
TI Immediate application of negative pressure wound therapy following lower
   extremity flap reconstruction in sixteen patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAPS; CONGESTION; SAFETY
AB Negative pressure wound therapy (NPWT) is usually applied in wound management and soft-tissue salvage after the development of complications. However, immediate postoperative application of NPWT over the flap coverage is seldom reported. We evaluate the effectiveness of immediate postoperative application of NPWT following fasciocutaneous or muscle flap coverage for lower leg reconstruction. A retrospective review of patients who underwent either fasciocutaneous or muscle flap coverage of lower leg soft-tissue defects applied with NPWT immediately after surgery was conducted in a level I trauma center. Sixteen patients, with an average age of 51.2 years, were included in the study. Nine patients had trauma-related soft-tissue loss, six had subsequent soft-tissue defects after debridement, and one had burn injury. Two patients had been treated with free anterolateral thigh flaps, 11 with pedicle flaps, and three with muscle flaps. All flaps survived except for those in two patients with venous congestion on postoperative day 1, which needed further debridement and skin grafting. Therefore, the use of immediate incisional NPWT is an alternative for wound care following flap coverage. The U-shaped design allows easy flap observation and temperature check. Furthermore, this method eliminates any concerns of vascular pedicle compression under negative pressure.
C1 [Chen, Chun-Yu; Tarng, Yih-Wen; Lin, Kai-Cheng] Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Ta Chung 1st Rd, Kaohsiung, Taiwan.
   [Chen, Chun-Yu; Lin, Kai-Cheng] Shu Zen Jr Coll Med & Management, Dept Occupat Therapy, Kaohsiung, Taiwan.
   [Chen, Chun-Yu; Kuo, Shyh-Ming] I Shou Univ, Dept Biomed Engn, Kaohsiung, Taiwan.
C3 Kaohsiung Veterans General Hospital; I Shou University
RP Lin, KC (通讯作者)，Kaohsiung Vet Gen Hosp, Dept Orthopaed, 386 Ta Chung 1st Rd, Kaohsiung, Taiwan.; Lin, KC (通讯作者)，Shu Zen Jr Coll Med & Management, Dept Occupat Therapy, Kaohsiung, Taiwan.
EM orthokcl@gmail.com
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NR 31
TC 11
Z9 16
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 27
PY 2021
VL 11
IS 1
AR 21158
DI 10.1038/s41598-021-00369-5
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XK1JP
UT WOS:000727230500009
PM 34707109
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Anghel, EL
   Kim, PJ
AF Anghel, Ersilia L.
   Kim, Paul J.
TI Negative-Pressure Wound Therapy: A Comprehensive Review of the Evidence
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; THICKNESS
   SKIN-GRAFTS; DIABETIC FOOT ULCERS; MULTICENTER; INSTILLATION; FRACTURES;
   FOAM
AB Background: Negative-pressure wound therapy (NPWT) and its variations are an established adjunctive modality for the treatment of wounds. Since its introduction, there have been an increasing number of publications with periods of rapid increases in the number of publications after innovations to the technology. Its application in different wound types and varying clinical scenarios has also contributed to the growing number of publications.
   Methods: A comprehensive literature review (1998-2016) was performed using key words most relevant to NPWT using PubMed/Medline and OVID. Eligibility criteria included higher level evidence studies.
   Results: One thousand three hundred and forty-seven publications were identified. A total of 26 publications are included in this review: 16 comparing NPWT with standard wound dressing, 6 comparing variations of NPWT, and 4 for NPWT with instillation. The level of evidence, wound type studied, reported outcomes and impact, and key findings are tabulated and discussed.
   Conclusions: The number of publications has grown significantly since the inception of NPWT. In part, this reflects the variations of NPWT that have developed. However, a greater number of robust, randomized, prospective studies are needed to support its wide spread use.
C1 MedStar Georgetown Univ Hosp, Dept Plast Surg, Div Wound Healing & Hyperbar Med, Washington, DC USA.
   [Kim, Paul J.] Georgetown Univ, Sch Med, Dept Plast Surg, Div Wound Healing & Hyperbar Med, 3800 Reservoir RD NW, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University
EM paul.j.kim@gunet.georgetown.edu
OI , Paul/0000-0002-6186-6890
FU KCI, an ACELITY Company
FX P. J. Kim has received research and consulting funding from KCI, an
   ACELITY Company, a manufacturer of negative-pressure wound therapy
   devices. E. L. Anghel has nothing to disclose.
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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NR 30
TC 59
Z9 79
U1 3
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 129S
EP 137S
DI 10.1097/PRS.0000000000002645
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300017
PM 27556753
DA 2026-07-24
ER

PT J
AU Cantatore, F
   Pagliara, E
   Marcatili, M
   Bertuglia, A
AF Cantatore, Federica
   Pagliara, Eleonora
   Marcatili, Marco
   Bertuglia, Andrea
TI Negative-Pressure Wound Therapy (NPWT) in Horses: A Scoping Review
SO VETERINARY SCIENCES
LA English
DT Review
DE horses; NPWT; VAC therapy; wound; skin grafts
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; INFECTIONS; LAPAROTOMY
AB Obtaining a healthy wound environment that is conductive to healing in horses can be challenging. Negative-pressure wound therapy (NPWT) has been employed in humans to enhance wound healing for decades. The existing evidence for the effectiveness of NPWT remains uncertain in equine medicine. The aim of this review is to investigate NPWT applications and benefits in horses. A scoping review was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines for scoping reviews on three databases (PubMed, Web of Science-Thompson Reuters, and Wiley Online Library). Twenty-four manuscripts were considered. After removing duplicates, 17 papers underwent abstract screening. Of these, 16 + 1 (cited by others) were evaluated for eligibility according to PICOs, including no case reports/retrospective studies, four original articles, and three reviews. Fifteen manuscripts met the inclusion criteria. The focus of the articles was wound management; they included three reports of wounds communicating with synovial structures. Traumatic wounds and surgical-site infections are indications for NPWT. NPWT presents several advantages and few complications making it an attractive alternative to conventional wound management. However, randomized controlled trials should be performed to quantify the benefits and establish precise protocols in horses.
C1 [Cantatore, Federica; Marcatili, Marco] IVC Evidensia, Pool House Equine Clin, Fradley WS13 8RD, Lichfield, England.
   [Pagliara, Eleonora; Bertuglia, Andrea] Univ Turin, Dept Vet Sci, I-10095 Grugliasco, Italy.
C3 University of Turin
RP Cantatore, F (通讯作者)，IVC Evidensia, Pool House Equine Clin, Fradley WS13 8RD, Lichfield, England.
EM fedecantatore10@gmail.com; eleonora.pagliara@unito.it;
   marco.marcatili86@gmail.com; andrea.bertuglia@unito.it
RI PAGLIARA, ELEONORA/IAO-6053-2023; BERTUGLIA, Andrea/ABG-2212-2021
OI PAGLIARA, ELEONORA/0000-0002-5616-5918; BERTUGLIA,
   Andrea/0000-0002-4442-2622; Marcatili, Marco/0000-0002-5449-6780; ,
   federica/0000-0003-1745-6146
FU The authors would like to thank Richard Stephenson for the help with the
   English translation.
FX The authors would like to thank Richard Stephenson for the help with the
   English translation.
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NR 35
TC 6
Z9 7
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2306-7381
J9 VET SCI
JI Vet. Sci.
PD AUG
PY 2023
VL 10
IS 8
AR 507
DI 10.3390/vetsci10080507
PG 13
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA Q2FO6
UT WOS:001055729000001
PM 37624295
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gill, NA
   Hameed, A
   Sajjad, Y
   Ahmad, Z
   Mirza, MAR
AF Gill, Nauman Ahmad
   Hameed, Abdul
   Sajjad, Yawar
   Ahmad, Zeeshan
   Mirza, Mohammad Ali Rafique
TI "Homemade" Negative Pressure Wound Therapy: Treatment of Complex Wounds
   Under Challenging Conditions
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RECONSTRUCTION
AB Background. Complex wounds pose a challenge to the surgeons regarding coverage and reconstruction. Negative pressure wound therapy (NPWT) has become a widely accepted technology for managing such wounds. Despite the case reports suggesting excellent outcomes of commercially available NPWT systems, there is paucity of randomized, controlled trials. Homemade alternatives can be of great use in hospitals with limited resources if they are found to be effective for managing complex wounds. Objective. To determine the effectiveness of "homemade" NPWT for coverage of challenging and difficult wounds of different regions of the body with limited options for reconstruction. Methods. Forty-four patients with 51 complex wounds involving different parts of body were included in the study. After initial debridement, the patients were treated with NPWT to obtain a healthy granulating wound bed that could be covered with simple reconstruction (ie, skin graft). Results. The average number of dressing changes was 2.9 and the average duration from start of therapy until the wound was ready for coverage was 13 days. Forty-seven wounds were skin grafted and 3 wounds were covered with local turnover flaps. One post sternotomy wound healed by secondary intention. Conclusion. This simple "homemade" NPWT system is an effective technique for treating challenging wounds on various parts of the body.
C1 [Gill, Nauman Ahmad; Hameed, Abdul; Sajjad, Yawar; Ahmad, Zeeshan; Mirza, Mohammad Ali Rafique] Shaikh Zayed Hosp, Dept Plast & Reconstruct Surg, Fed Postgrad Med Inst, Lahore, Pakistan.
RP Gill, NA (通讯作者)，Shaikh Zayed Hosp, Dept Plast & Reconstruct Surg, Fed Postgrad Med Inst, Block D, Lahore, Pakistan.
EM naumangill22@yahoo.co.uk
RI Ahmad, Zeeshan/KIJ-6670-2024
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NR 18
TC 12
Z9 14
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2011
VL 23
IS 4
BP 84
EP 92
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 755VR
UT WOS:000289968200003
PM 25881336
DA 2026-07-24
ER

PT J
AU Muenchow, S
   Horch, RE
   Dragu, A
AF Muenchow, S.
   Horch, R. E.
   Dragu, A.
TI Effects of topical negative pressure therapy on perfusion and
   microcirculation of human skin
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Topical negative pressure wound therapy; tissue - laser/photo -
   spectrometry; microvascular tissue perfusion
ID VACUUM-ASSISTED CLOSURE; WOUND THERAPY; LASER-DOPPLER; SOCIETY
AB BACKGROUND: Topical negative pressure wound therapy (TNPWT) is one of the most frequently used techniques in wound treatment. But some of the underlying mechanisms still remain unclear. One possible explanation is an improved microcirculation by TNPWT.
   OBJECTIVE: This study investigated the influence of TNPWT on microcirculation on intact skin in real-time.
   METHODS: In healthy individuals, we performed a combined tissue - laser/photo - spectrometry technique to monitor changes of 4 different microcirculation parameters in real-time: The local blood flow, the capillary-venous oxygen saturation, the blood flow velocity and the relative amount of hemoglobin. We compared these parameters using two different protocols: a continuously (VAC ON 60/OFF 60) and discontinuously (VAC ON 30/OFF 60/ON 5) application.
   RESULTS: Our results demonstrate a significant increase of all four measured parameters during the active TNPWT and the pressure free period. The comparison of two different protocols shows an advantage of the examined parameters using a discontinuous TNPWT application.
   CONCLUSIONS: Our study demonstrated the changes of the microvascular tissue perfusion in intact human skin under the conditions of negative pressure and may thereby offer a broader understanding of mechanisms underlying the TNPWT.
C1 [Muenchow, S.; Dragu, A.] Tech Univ Dresden, Dept Plast & Hand Surg, Univ Hosp Dresden, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.
   [Muenchow, S.; Horch, R. E.] Friedrich Alexander Univ Erlangen Nurnberg, Dept Plast & Hand Surg, Univ Hosp, Erlangen, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of Erlangen Nuremberg
RP Dragu, A (通讯作者)，Tech Univ Dresden, Dept Plast & Hand Surg, Univ Hosp Dresden, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany.
EM adrian.dragu@uniklinikum-dresden.de
RI Dragu, Adrian/AAH-3506-2019; Horch, Raymund/H-8128-2019
OI Dragu, Adrian/0000-0003-4633-2695; 
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NR 31
TC 32
Z9 35
U1 0
U2 0
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2019
VL 72
IS 4
BP 365
EP 374
DI 10.3233/CH-180536
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA JA8EJ
UT WOS:000488082600004
PM 30909192
DA 2026-07-24
ER

PT J
AU Etöz, A
   Özgenel, Y
   Özcan, M
AF Etöz, A
   Özgenel, Y
   Özcan, M
TI The use of negative pressure wound therapy on diabetic foot ulcers: A
   preliminary controlled trial
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; DEGLOVING INJURIES
AB The purpose of this clinical study was to investigate the effects of negative pressure wound therapy (NPWT) on the healing of diabetic foot ulcers and to compare this dressing with traditional moist gauze dressing as a treatment used prior to other wound closure techniques, such as flaps or grafts. Twenty-four diabetic patients were randomly divided into two groups: NPWT group and control group. Initially, the mean surface area of the diabetic wounds was 109cm(2) in the NPWT group and 94.8cm(2) in the control group. The mean duration of wound care (until the wounds were covered with granulation tissue) was 11.25 days in the NPWT group and 15.75 in the control group (p=0.05); following NPWT or moist guaze dressing, the mean surface area of the wounds was 88.6cm(2) in NPWT group and 85.3 cm(2) in control group (p<0.05). In conclusion, the use of NPWT may be an alternative therapy to achieve a faster granulating wound bed in diabetic foot ulcers in order to prepare the wound bed for other closure techniques. Further studies are needed to clarify effects and indications and to modify the technique of this treatment for nonhealing wounds.
C1 Uludag Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-16059 Gorukle, Bursa, Turkey.
C3 Uludag University
RP Etöz, A (通讯作者)，Uludag Univ, Fac Med, Dept Plast & Reconstruct Surg, TR-16059 Gorukle, Bursa, Turkey.
EM etoz@yahoo.com
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   DeFranzo AJ, 1999, PLAST RECONSTR SURG, V104, P2145, DOI 10.1097/00006534-199912000-00031
   Joseph E, 2000, WOUNDS, V12, P60
   Josty IC, 2001, BRIT J PLAST SURG, V54, P363, DOI 10.1054/bjps.2000.3565
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   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Mullner T, 1997, BRIT J PLAST SURG, V50, P194, DOI 10.1016/S0007-1226(97)91369-2
NR 13
TC 47
Z9 56
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2004
VL 16
IS 8
BP 264
EP 269
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 849AG
UT WOS:000223509000003
DA 2026-07-24
ER

PT J
AU Mughal, M
   Baker, RJ
   Muneer, A
   Mosahebi, A
AF Mughal, M.
   Baker, R. J.
   Muneer, A.
   Mosahebi, A.
TI Reconstruction of perineal defects
SO ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
LA English
DT Review
DE Perineal reconstruction; Perineal wound; Negative pressure wound
   therapy; Local flaps for perineum; Perforator flaps; Wound management
ID VACUUM ASSISTED CLOSURE; THIGH FLAPS; THERAPY
AB INTRODUCTION Perineal defects are commonly encountered in an oncological setting although they may also present as a result of trauma and infection (eg following Fournier's gangrene). Reconstruction of these poses functional as well as aesthetic challenges. Skin coverage and tissue volume may both be required in addition to anogenital preservation or reconstruction. General prerequisites of an adequate reconstruction of perineal defects include provision of skin cover, well vascularised tissue to fill the dead space (reducing fluid collection and infection), vulvovaginal reconstruction and no faecal or urinary contamination.
   METHODS A literature search was performed using PubMed and MEDLINE (R). The search terms included 'perineal defects', 'perineal reconstruction', 'perforator flaps for perineum', 'vulval flaps', 'secondary healing of wound' and 'vacuum assisted closure'. Backward chaining of reference lists from retrieved papers was also used to expand the search.
   FINDINGS Modern developments have led to an increased expectation in improved quality of life as the main goal of reconstruction, therefore necessitating surgery with less morbidity and early return to normal activity. Progress in microsurgical procedures has been the main recent advance in perineal reconstruction and, in future, refinements in perforator flap design and tissue engineering techniques will lead to even better reconstructions.
C1 [Mughal, M.; Baker, R. J.; Mosahebi, A.] Royal Free London NHS Fdn, London, England.
   [Muneer, A.] UCL, Hosp NHS Fdn, London WC1E 6BT, England.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; University of London; University College London
RP Mughal, M (通讯作者)，Royal Free Hosp, Pond St, London NW3 2QG, England.
EM leeha_h82@hotmail.com
CR Ahmadzadeh R, 2007, PLAST RECONSTR SURG, V120, P1551, DOI 10.1097/01.prs.0000282098.61498.ee
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NR 31
TC 40
Z9 50
U1 0
U2 5
PU ROYAL COLL SURGEONS ENGLAND
PI LONDON
PA 35-43 LINCOLN'S INN FIELDS, LONDON WC2A 3PN, ENGLAND
SN 0035-8843
EI 1478-7083
J9 ANN ROY COLL SURG
JI Ann. R. Coll. Surg. Engl.
PD NOV
PY 2013
VL 95
IS 8
BP 539
EP 544
DI 10.1308/rcsann.2013.95.8.539
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 261PN
UT WOS:000327677200001
PM 24165333
OA Bronze
DA 2026-07-24
ER

PT J
AU Klein, DS
   Yingling, JM
   Patel, P
   Capo, JT
AF Klein, David S.
   Yingling, John M.
   Patel, Priya
   Capo, John T.
TI Vacuum-Assisted Therapy for Combined Volar-Dorsal Soft-Tissue Defects of
   the Hand: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE glove; hand; negative-pressure wound therapy; NPWT; soft-tissue defect;
   trauma; vacuum-assisted closure; wound
ID CLOSURE; THUMB
AB Application of negative-pressure wound therapy dressings to the web spaces and small, often moist, areas of the hand can be technically demanding and time consuming. The researchers present a case report and technique for managing a devastating hand infection and soft-tissue defects by creating a self-fabricated sponge glove that is easily reproducible. Vacuum-assisted therapy for combined volar dorsal soft-tissue defects of the hand, or "Hand Vac," is a novel approach for treating extensive hand wounds. This technique was used in a patient with diabetes with a deep space infection of the hand following serial debridements and antibiotic bead therapy. A single, medium-size sponge was cut using a knife and scissors to create an easily applied glove that was then sealed with adhesive dressing and a single suction port. The patient avoided complete amputation of the hand and deep infection was eradicated. The wounds had progressive granulation and healing and were eventually covered with split-thickness skin grafts. The authors conclude that severe soft-tissue defects involving both the volar and dorsal aspects of the hand can be effectively managed with a single glove-like sponge and suction port.
C1 [Klein, David S.] Morristown Med Ctr, Tri Cty Orthoped, Dept Orthoped Surg, Cedar Knolls, NJ 07960 USA.
   [Yingling, John M.] Jersey City Med Ctr RWJBarnabas Hlth, Dept Orthoped Surg, Jersey City, NJ USA.
   [Patel, Priya] Jersey City Med Ctr RWJBarnabas Hlth, Hand Surg, Jersey City, NJ USA.
   [Capo, John T.] Jersey City Med Ctr RWJBarnabas Hlth, Div Hand Surg, Jersey City, NJ USA.
C3 Atlantic Health System
RP Klein, DS (通讯作者)，Morristown Med Ctr, Tri Cty Orthoped, Dept Orthoped Surg, Cedar Knolls, NJ 07960 USA.
CR Aras A, 2016, J CLIN DIAGN RES, V10, pPD19, DOI 10.7860/JCDR/2016/18485.7659
   Aydin Ufuk, 2011, Tech Hand Up Extrem Surg, V15, P104, DOI 10.1097/BTH.0b013e3181f73307
   Chen LH, 2015, MEDICINE, V94, P1, DOI 10.1097/MD.0000000000001575
   Elliot D, 2018, J HAND SURG-EUR VOL, V43, P1019, DOI 10.1177/1753193418805698
   Friedrich JB, 2009, J HAND SURG-AM, V34A, P1148, DOI 10.1016/j.jhsa.2009.04.035
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   Kasukurthi Rahul, 2010, Hand (N Y), V5, P95, DOI 10.1007/s11552-009-9209-4
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Lesiak AC, 2013, J HAND SURG-AM, V38A, P1828, DOI 10.1016/j.jhsa.2013.04.029
   Moni ASB, 2019, J HAND SURG-ASIAN-PA, V24, P317, DOI 10.1142/S2424835519500401
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   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
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NR 18
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2022
VL 35
IS 1
BP 57
EP 61
DI 10.1097/01.ASW.0000771980.02715.5c
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA 8W7IY
UT WOS:000931502800013
PM 34412063
DA 2026-07-24
ER

PT J
AU Franco-Buenaventura, D
   García-Perdomo, HA
AF Franco-Buenaventura, Daniela
   Garcia-Perdomo, Herney Andres
TI Vacuum-assisted closure device in the postoperative wound care for
   Fournier's gangrene: a systematic review
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Fournier gangrene; Negative-pressure wound therapy;
   Vacuum-assisted&#160; closure
ID THERAPY; MANAGEMENT
AB Purpose To determine the effectiveness of Vacuum-Assisted Closure Device in the postoperative wound care for Fournier's gangrene Methods We performed a systematic review in the following databases: Medline (Ovid), EMBASE, and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We included RCTs and analytical observational studies. Meta-analysis was not possible given the clinical and methodological heterogeneity of the studies. Results We included six studies that compared VAC treated patients and a control group. The length of stay of the VAC treated vs. the conventional dressing treated patients was higher for the VAC treated patients in all but one of the included studies. The VAC group had the highest number of surgical debridements requiring anesthesia. The conventionally treated patients had a higher number of daily dressings, and the need for additional dressing changes, without anesthesia. Two studies found significantly higher mean scores for VAS, requiring a higher need for daily analgesics for the control group patients. Conclusions VAC therapy is an effective method, but it is not better than conventional dressing treatment. VAC carries fewer dressing changes, less pain, and less need for analgesics, but it comes with a higher need for surgical interventions requiring anesthesia.
C1 [Franco-Buenaventura, Daniela; Garcia-Perdomo, Herney Andres] Univ Valle, Sch Med, Dept Surg Urol, Cali, Colombia.
   [Franco-Buenaventura, Daniela; Garcia-Perdomo, Herney Andres] Univ Valle, UROGIV Res Grp, Cll 4B,36-00, Cali, Colombia.
C3 Universidad del Valle; Universidad del Valle
RP García-Perdomo, HA (通讯作者)，Univ Valle, Sch Med, Dept Surg Urol, Cali, Colombia.; García-Perdomo, HA (通讯作者)，Univ Valle, UROGIV Res Grp, Cll 4B,36-00, Cali, Colombia.
EM herney.garcia@correounivalle.edu.co
RI Garcia-Perdomo, Herney Andres/G-9701-2013
OI Garcia-Perdomo, Herney Andres/0000-0001-6945-8261
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Atakan Irfan Huseyin, 2002, International Urology and Nephrology, V34, P387, DOI 10.1023/A:1024427418743
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NR 25
TC 18
Z9 19
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD APR
PY 2021
VL 53
IS 4
BP 641
EP 653
DI 10.1007/s11255-020-02705-6
EA NOV 2020
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA RK2TP
UT WOS:000589478200001
PM 33185760
DA 2026-07-24
ER

PT J
AU Inatomi, Y
   Kadota, H
   Kamizono, K
   Hanada, M
   Yoshida, S
AF Inatomi, Yusuke
   Kadota, Hideki
   Kamizono, Kenichi
   Hanada, Masuo
   Yoshida, Sei
TI Securing split thickness skin grafts using negative-pressure wound
   therapy without suture fixation
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE graft shearing; negative-pressure wound therapy (NPWT); no suture; skin
   graft fixation; split-thickness skin graft
ID VACUUM-ASSISTED CLOSURE
AB Objective: Negative-pressure wound therapy (NPWT) is generally applied as a bolster for split-thickness skin grafts (STSG) after the graft has been secured with sutures or skin staples. In this study, NPWT was applied to secure STSGs without any sutures or staples. Surgical outcomes of using NPWT without sutures was compared with a control group.
   Methods: Patients with STSGs were divided into two groups: a 'no suture' group using only NPWT, and a control group using conventional fixings. In the no suture group, the grafts were covered with meshed wound dressing and ointment. The NPWT foam was placed over the STSG and negative pressure applied. In the control group, grafts were fixed in place using tie-over bolster, securing with fibrin glue, or NPWT after sutures.
   Results: A total of 30 patients with 35 graft sites participated in the study. The mean rate of graft take in the no suture group was 95.1%, compared with 93.3% in the control group, with no significant difference between them. No graft shearing occurred in the no suture group. Although the difference did not reach statistical significance, mean surgical time in the no suture group (31.5 minutes) tended to be shorter than that in the control group (55.7 minutes).
   Conclusion: By eliminating sutures, the operation time tended to be shorter, suturing was avoided and suture removal was not required meaning that patients could avoid the pain associated with this procedure. Furthermore, the potential for staple retention and its associated complications was avoided, making this method potentially beneficial for both medical staff and patients.
C1 [Inatomi, Yusuke; Kadota, Hideki; Kamizono, Kenichi; Hanada, Masuo; Yoshida, Sei] Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, Fukuoka, Fukuoka, Japan.
C3 Kyushu University
RP Inatomi, Y (通讯作者)，Kyushu Univ Hosp, Dept Plast & Reconstruct Surg, Higashi Ku, Fukuoka, Fukuoka, Japan.
EM xkxmy557@gmail.com
RI /AAU-7710-2020
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Blackburn JH, 1998, ANN PLAS SURG, V40, P453, DOI 10.1097/00000637-199805000-00001
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   Inatomi Y, 2015, JPN J PLAST RECON SU, V35, P487
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   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
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   Schneider AM, 1998, PLAST RECONSTR SURG, V102, P1195, DOI 10.1097/00006534-199809040-00045
NR 10
TC 9
Z9 13
U1 0
U2 1
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD AUG 1
PY 2019
VL 28
IS 8
SU S
BP S16
EP S21
DI 10.12968/jowc.2019.28.Sup8.S16
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IP8NV
UT WOS:000480304000003
PM 31393782
DA 2026-07-24
ER

PT J
AU Maurya, S
   Bhandari, PS
AF Maurya, Sanjay
   Bhandari, Prem Singh
TI Negative Pressure Wound Therapy in the Management of Combat Wounds: A
   Critical Review
SO ADVANCES IN WOUND CARE
LA English
DT Review
DE combat wounds; negative pressure wound therapy; wound debridement;
   delayed wound closure; soft tissue reconstruction
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; WAR WOUNDS;
   EXPERIENCE; DEVICE; TRIAL; PROLIFERATION; DEBRIDEMENT; FOUNDATION;
   MECHANISM
AB Significance: Wounds sustained in a combat trauma often result in a composite tissue loss. Combat injuries, due to high energy transfer to tissues, lead to trauma at multiple anatomical sites. An early wound cover is associated with lower rate of infections and a faster wound healing. The concept of negative pressure wound therapy (NPWT) in the management of combat-related wounds has evolved from the civilian trauma and the wounds from nontraumatic etiologies. Recent Advances: Encouraged by the results of NPWT in noncombat-related wounds, the military surgeons during Operation Iraqi Freedom and Operation Enduring Freedom used this novel method in a large percentage of combat wounds, with gratifying results. The mechanism of NPWT in wound healing is multifactorial and often complex reconstructive procedure can be avoided in a combat trauma setting. Critical Issues: Wounds sustained in military trauma are heavily contaminated with dirt, patient clothing, and frequently associated with extensive soft tissue loss and osseous destruction. Delay in evacuation during an ongoing conflict carries the risk of systemic infection. Early debridement is indicated followed by delayed closure of wounds. NPWT helps to provide temporary wound cover during the interim period of debridement and wound closure. Future Directions: Future area of research in combat wounds is related to abdominal trauma with loss of abdominal wall. The concept of negative pressure incisional management system in patients with a high risk of wound breakdown following surgery is under review, and may be of relevance in combat wounds.
C1 [Maurya, Sanjay; Bhandari, Prem Singh] Command Hosp, Dept Plast & Reconstruct Surg, Udhampur 182101, India.
RP Maurya, S (通讯作者)，Command Hosp, Dept Plast & Reconstruct Surg, Udhampur 182101, India.
EM drsanjaymaurya@hotmail.com
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NR 51
TC 21
Z9 27
U1 3
U2 22
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD SEP
PY 2016
VL 5
IS 9
BP 379
EP 389
DI 10.1089/wound.2014.0624
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DV9RS
UT WOS:000383279600001
PM 27679749
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Gratteri, M
   Luciano, C
   Romano, FD
   Abate, L
   Mirra, C
   Savani, L
   Papalia, GF
   Papalia, R
   Farsetti, P
   Marangi, GF
   Persichetti, P
AF Gratteri, Marco
   Luciano, Claudia
   Romano, Fara Desiree
   Abate, Luigi
   Mirra, Carlo
   Savani, Luca
   Papalia, Giuseppe Francesco
   Papalia, Rocco
   Farsetti, Pasquale
   Marangi, Giovanni Francesco
   Persichetti, Paolo
TI Negative Pressure Wound Therapy for Management of Achilles Region
   Defects: A Systematic Review of the Literature
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE Achilles tendon; NPWT; negative pressure; negative pressure wound
   therapy; skin graft; flap; Achilles tendon; NPWT; negative pressure;
   Achilles tendon; negative pressure wound therapy; NPWT; skin graft;
   negative pressure; flap; negative pressure wound therapy; skin graft;
   flap
ID SOFT-TISSUE DEFECTS; TENDON RUPTURES; SKIN
AB Background. Despite the efforts of plastic and orthopedic surgeons to elaborate the most appropriate treatment for lesions of the Achilles region and their reconstruction, no universal guideline exists. Regenerative treatments such as negative pressure wound therapy (NPWT) are increasingly being used in the management of these defects. Objective. To research the different usage protocols, roles, and outcomes of NPWT in the management and reconstruction of Achilles region defects. Methods. A scientific literature search was performed by querying Medline and Scopus using the terms "(Achilles tendon) AND ((vac) OR (vacuum assisted closure) OR (negative pressure) OR (NPWT))." The authors used an online screening software. The investigation followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for systematic review. Results. Of the initial 153 studies identified, only 14 fulfilled the eligibility criteria and were included in this review. Analyzed protocols mainly included surgical debridement combined with the use of NPWT as a primary dressing directly on the tendon or as a secondary dressing covering a splitthickness skin graft (STSG) or a flap. Additionally, the combination of negative pressure with matrices was found to provide optimal results even after STSG failure. Most of the reported complications described in the included studies involved partial loss of graft or flap. Conclusion. NPWT can be used either as a primary dressing (directly on the lesion) or as a secondary dressing (over a flap or a skin graft) for management of Achilles region defects. The combined use of negative pressure with matrices can also aid in wound reduction.
C1 [Gratteri, Marco; Romano, Fara Desiree; Abate, Luigi; Mirra, Carlo; Savani, Luca; Marangi, Giovanni Francesco; Persichetti, Paolo] Campus Biomed Univ Rome, Dept Plast Reconstruct & Aesthet Surg, Via Alvaro Del Portillo 200, I-00128 Rome, Italy.
   [Luciano, Claudia; Farsetti, Pasquale] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Sect Orthopaed & Traumatol, Rome, Italy.
   [Papalia, Giuseppe Francesco; Papalia, Rocco] Campus Biomed Univ Rome, Dept Orthopaed & Trauma Surg, Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of Rome Tor
   Vergata; University Campus Bio-Medico - Rome Italy
RP Romano, FD (通讯作者)，Campus Biomed Univ Rome, Dept Plast Reconstruct & Aesthet Surg, Via Alvaro Del Portillo 200, I-00128 Rome, Italy.
EM faradesiree.romano@unicampus.it
RI Papalia, Rocco/I-9192-2014; Papalia, Giuseppe Francesco/ACO-2068-2022;
   Gratteri, Marco/KGM-5481-2024; Marangi, Giovanni/AAW-4723-2020
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2025
VL 37
IS 5
BP 186
EP 197
DI 10.25270/wnds/24180
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3YC6O
UT WOS:001511774400003
PM 40512681
DA 2026-07-24
ER

PT J
AU Esen, E
   Saydam, M
   Guler, S
   Akinci, M
   Bahcecioglu, IB
   Gulcelik, MA
   Yilmaz, KB
AF Esen, Ebru
   Saydam, Mehmet
   Guler, Sumeyra
   Akinci, Melih
   Bahcecioglu, Ibrahim Burak
   Gulcelik, Mehmet Ali
   Yilmaz, Kerim Bora
TI Successful use of minimal invasive debridement plus negative pressure
   wound therapy under skin flap and axillary region for refractory
   postmastectomy seroma: A STROBE-compliant retrospective study
SO MEDICINE
LA English
DT Article
DE mastectomy; negative pressure wound therapy; seroma
ID INFLAMMATORY CYTOKINE LEVELS; VACUUM-ASSISTED CLOSURE; RISK-FACTORS;
   ELECTROCAUTERY; COMPLICATIONS; MASTECTOMY; SCALPEL
AB Seroma is the most common wound complication due to dead space remaining after mastectomy and axillary dissection. Seroma formation, which causes pain and tension, together with the limitations of shoulder and arm movements, can cause wound healing problems that can progress to wound dehiscence and flap necrosis. The aim of our study was to investigate the effects of continuous drainage and negative pressure wound therapy (NPWT) in breast cancer patients with refractory postmastectomy seroma. This retrospectively designed study was conducted with 27 patients who were referred to our center between 2018 and 2021 due to refractory seroma after mastectomy. The inclusion criteria of the study were the cases who were planned minimally invasive debridement and NPWT due to having refractory seroma formation with at least 200 cc and having interventions more than 1 month after modified radical mastectomy (MRM), despite conventional treatment methods. All patients' demographics, disease stage, history of possible neoadjuvant therapy, comorbidities, body mass index (BMI), number of wound dressings with NPWT, and total amount of NPWT accumulation were enrolled and compared statistically. Twenty-seven patients included in the study underwent continuous drainage after debridement, and 5 (3-9) dressings were treated with NPWT. None of the patients experienced complications after debridement and NPWT administration. In refractory seroma cases seen after postmastectomy, NPWT especially for the management of debridement and dead space can be evaluated as an appropriate treatment method in patients with high flow rate seroma.
C1 [Esen, Ebru; Bahcecioglu, Ibrahim Burak; Gulcelik, Mehmet Ali] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Surg Oncol, Ankara, Turkey.
   [Saydam, Mehmet; Guler, Sumeyra] Univ Hlth Sci, Diskapi Res & Training Hosp, Dept Gen Surg, Ankara, Turkey.
   [Akinci, Melih; Yilmaz, Kerim Bora] Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Gen Surg, Ankara, Turkey.
C3 Gulhane Training & Research Hospital; University of Health Sciences
   Turkey; Diskapi Yildirim Beyazit Training & Research Hospital;
   University of Health Sciences Turkey; University of Health Sciences
   Turkey; Gulhane Training & Research Hospital
RP Esen, E (通讯作者)，Univ Hlth Sci, Gulhane Res & Training Hosp, Dept Surg Oncol, Gen Tevf Saglam Cd 1, TR-06010 Kecioren Ankara, Turkey.
EM drebnesen@gmail.com
RI gulcelik, Mehmet/LKK-6450-2024; Yilmaz, Kerim Bora/HJI-8568-2023; esen,
   ebru/U-4613-2018
OI SAYDAM, Mehmet/0000-0003-0953-4589; Yilmaz, Kerim
   Bora/0000-0002-5514-4103; esen, ebru/0000-0003-3019-0872
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   Yilmaz KB, 2011, J BREAST CANCER, V14, P58, DOI 10.4048/jbc.2011.14.1.58
NR 23
TC 3
Z9 5
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 28
PY 2022
VL 101
IS 43
AR e31634
DI 10.1097/MD.0000000000031634
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5V5UQ
UT WOS:000877294300053
PM 36316850
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Simon, K
   Schulz-Drost, M
   Besendörfer, M
   Carbon, RT
   Schulz-Drost, S
AF Simon, K.
   Schulz-Drost, M.
   Besendoerfer, M.
   Carbon, R. T.
   Schulz-Drost, S.
TI Use of Negative Pressure Wound Therapy on Surgical Incisions (Prevena™)
   after Surgery of Pectus Deformities Reduces Wound Complications
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE pectus repair surgery; preventive negative pressure wound therapy;
   Prevena (TM); postoperative wound healing disorder; wound infection; VAC
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS;
   MANAGEMENT-SYSTEM; CARDIAC-SURGERY; RISK-FACTORS; STERNOTOMY; INFECTION;
   PREVENTION; EXPERIENCE; SURVIVAL
AB Introduction: Pectus surgery can lead to postoperative wound complications in some cases. The purpose of this study is to determine whether preventive negative pressure wound therapy (NPWT) could reduce wound complications after open pectus surgery.
   Material and Methods: 100 patients after open procedure for the treatment of pectus excavatum or pectus carinatum in the years 2010 to 2012 were retrospectively analysed. 50 patients treated with Prevena (TM) (KCI Medical Products GmbH, Wiesbaden, Germany) were compared with 50 patients whose wounds were covered with OPSITE (R) film (Smith & Nephew, Hamburg, Germany). Wound closure was performed following a standard procedure as well as the placement of subcutaneous drains. Therefore two comparable groups of patients were formed and analysed by standardised parameters. The wound dressing was placed epicutaneously immediately after wound closure in the operating room and removed after 5 days in each case. Follow-ups were performed immediately after removal of the wound dressing, at the time of discharge from hospital as well as 6 and 12 weeks after operation. The wounds were checked for tenderness, pain, secretion, redness and fistulas.
   Results: The Prevena group showed 10% wound complications which needed operative treatment, whereas the OPSITE group showed complications in 24%. Some patients who were treated with Prevena showed superficial skin lesions at the rim of the foam and the film. All of these lesions healed well.
   Conclusion: Treating wounds postoperatively with preventive measures (NPWT) showed a remarkable reduction of wound complications following open pectus surgery whereas statistically the difference was not significant (p = 0.074).
C1 [Simon, K.; Besendoerfer, M.; Carbon, R. T.; Schulz-Drost, S.] Univ Klinikum Erlangen, Kinderchirurg Abt, D-91054 Erlangen, Germany.
   [Schulz-Drost, M.] Univ Klinikum Erlangen, Arztliche DRG Koordinat, D-91054 Erlangen, Germany.
   [Schulz-Drost, S.] Univ Klinikum Erlangen, Unfallchirurg Abt, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Schulz-Drost, S (通讯作者)，Univ Klinikum Erlangen, Kinderchirurg Abt, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM stefan.schulz-drost@uk-erlangen.de
OI Besendörfer, Manuel/0000-0001-8679-4646
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   Reddix Robert N Jr, 2009, Am J Orthop (Belle Mead NJ), V38, P446
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NR 28
TC 5
Z9 5
U1 0
U2 12
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD APR
PY 2015
VL 140
IS 2
BP 156
EP 162
DI 10.1055/s-0033-1360291
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CG8UQ
UT WOS:000353590100010
PM 24647815
DA 2026-07-24
ER

PT J
AU Nuutila, K
   Broomhead, M
   Proppe, K
   Eriksson, E
AF Nuutila, Kristo
   Broomhead, Michael
   Proppe, Karl
   Eriksson, Elof
TI Study Comparing Platform Wound Dressing, a Negative-Pressure Device
   without a Filler, with Three Conventional Negative-Pressure Wound
   Therapy Systems in the Treatment of Excisional and Incisional Wounds
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; GAUZE; CONTRACTION; PARADOX; FOAM
AB Background: All common negatiVe-pressure wound therapy systems include a material, usually foam or gauze, at the wound/ device interface. In this precliniral study, the authors have compared the effects on different wound healing parameters in the three most common negative-pressure wound therapy systems (i.e., V.A.C.VIA, PREVENA, and PICO) with a new device without foam or gauze (i.e., Platform Wound Dressing). A strong effort was made to avoid bias. The study was conducted under good laboratory practice conditions, with the presence of an independent observer.
   Methods: In pigs, three types of wounds were studied: full-thickness excisions, open incisions, and sutured dosed incisions. Several macroscopic and microscopic parameters were studied. The pigs were euthanized on day 9 and all wounds were processed for histology and excisions 101 immunohistochemistry.
   Results: In general, the devices produced similar results, with only a few significant differences. In the excisions, the Platform I'Vound Dressing reduced wound area more than the V.A.C.VIA and the PICO, In the extisional wounds, reepithelialifation was the saute. in open incisions, PREVENA was better than the Platform Wound Dressing. Histologic examination showed that, in open incisions, there was less inflammation in the PREVENA-treated in comparison with the Platform Wound Dressing- and the PICO-treated wounds, butte mohistochemical analyses showed that the Platform Wound Dressing-treated excisions had significantly more blood vessels (von Willebrand factor) than the VA.C.VIA-treated ones and that the PICO caused less T-cell activation (CDS) than the other two.
   Conclusion: The devices-with foam, with gauze, or without either and just an embossed inembrane-performed equally in general.
C1 [Nuutila, Kristo; Broomhead, Michael; Proppe, Karl; Eriksson, Elof] Appl Tissue Technol LLC, Hingham, MA USA.
RP Eriksson, E (通讯作者)，99 Derby St,Suite 200, Hingham, MA 02043 USA.
EM elof@comcast.net
FU U.S. Army Medical Research Acquisition Activity [W81XWH-16-1-0784]
FX All authors are employees of Applied Tissue Technologies, which
   manufactures the Platform Wound Dressings. This material is based upon
   work supported by the U.S. Army Medical Research Acquisition Activity
   under contract no. W81XWH-16-1-0784.
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NR 34
TC 9
Z9 10
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1
BP 76
EP 86
DI 10.1097/PRS.0000000000007450
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA PL4GG
UT WOS:000603081800021
PM 33370053
DA 2026-07-24
ER

PT J
AU Bellot, GL
   Dong, XK
   Lahiri, A
   Sebastin, SJ
   Batinic-Haberle, I
   Pervaiz, S
   Puhaindran, ME
AF Bellot, Gregory Lucien
   Dong, Xiaoke
   Lahiri, Amitabha
   Sebastin, Sandeep Jacob
   Batinic-Haberle, Ines
   Pervaiz, Shazib
   Puhaindran, Mark Edward
TI MnSOD is implicated in accelerated wound healing upon Negative Pressure
   Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants
   for wound management
SO REDOX BIOLOGY
LA English
DT Article
DE Negative pressure wound therapy; Skin wound healing; Manganese
   superoxide dismutase; MnSOD mimetics; MnTE-2-PyP5+
ID MANGANESE SUPEROXIDE-DISMUTASE; VACUUM-ASSISTED CLOSURE; GROWTH-FACTOR;
   EXPRESSION; ANGIOGENESIS; MECHANISMS; ENZYMES; TISSUE; OXYGEN
AB Negative Pressure Wound Therapy (NPWT), a widely used modality in the management of surgical and trauma wounds, offers clear benefits over conventional wound healing strategies. Despite the wide-ranging effects ascribed to NPWT, the precise molecular mechanisms underlying the accelerated healing supported by NPWT remains poorly understood. Notably, cellular redox status-a product of the balance between cellular reactive oxygen species (ROS) production and anti-oxidant defense systems-plays an important role in wound healing and dysregulation of redox homeostasis has a profound effect on wound healing. Here we investigated potential links between the use of NPWT and the regulation of antioxidant mechanisms. Using patient samples and a rodent model of acute injury, we observed a significant accumulation of MnSOD protein as well as higher enzymatic activity in tissues upon NPWT. As a proof of concept and to outline the important role of SOD activity in wound healing, we replaced NPWT by the topical application of a MnSOD mimetic, Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP5+, MnE, BMX-010, AEOI10113) in the rodent model. We observed that MnE is a potent wound healing enhancer as it appears to facilitate the formation of new tissue within the wound bed and consequently advances wound closure by two days, compared to the non-treated animals. Taken together, these results show for the first time a link between NPWT and regulation of antioxidant mechanism through the maintenance of MnSOD activity. Additionally this discovery outlined the potential role of MnSOD mimetics as topical agents enhancing wound healing.
C1 [Bellot, Gregory Lucien; Dong, Xiaoke; Lahiri, Amitabha; Sebastin, Sandeep Jacob; Puhaindran, Mark Edward] Natl Univ Hlth Syst, Univ Orthoped Hand & Reconstruct Microsurg Cluste, Dept Hand & Reconstruct Microsurg, Singapore, Singapore.
   [Bellot, Gregory Lucien; Pervaiz, Shazib] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
   [Pervaiz, Shazib] Natl Univ Singapore, Yong Loo Lin Sch Med, Med Sci Cluster Canc Program, Singapore, Singapore.
   [Batinic-Haberle, Ines] Duke Univ, Sch Med, Dept Radiat Oncol, Durham, NC USA.
   [Pervaiz, Shazib] Natl Univ Hlth Syst, Natl Univ Canc Inst, Singapore, Singapore.
   [Pervaiz, Shazib] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore.
   [Pervaiz, Shazib] Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA, Australia.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; Duke University; National University
   of Singapore; National University of Singapore; Curtin University
RP Puhaindran, ME (通讯作者)，Natl Univ Hlth Syst, Univ Orthoped Hand & Reconstruct Microsurg Cluste, Dept Hand & Reconstruct Microsurg, Singapore, Singapore.; Pervaiz, S (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
EM phssp@nus.edu.sg; mark_e_puhaindran@nuhs.edu.sg
RI /E-7820-2010; Pervaiz, Shazib/C-4188-2015; Lahiri,
   Amitabha/AAH-7384-2021
FU National Medical Research Council, Singapore [NMRC/CNIG/1089/2012];
   National University Health System (NUHS) Bridging fund [NR15MRF023OM]
FX This work was supported by the National Medical Research Council,
   Singapore (grant number NMRC/CNIG/1089/2012) and National University
   Health System (NUHS) Bridging fund (grant number NR15MRF023OM).
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NR 58
TC 39
Z9 43
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2019
VL 20
BP 307
EP 320
DI 10.1016/j.redox.2018.10.014
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HM3GK
UT WOS:000459361500026
PM 30390545
OA gold
DA 2026-07-24
ER

PT J
AU Tevanov, I
   Enescu, DM
   Carp, M
   Dusca, A
   Ladaru, A
   Ulici, A
AF Tevanov, Iulia
   Enescu, Dan Mircea
   Carp, Madalina
   Dusca, Andrei
   Ladaru, Alin
   Ulici, Alexandru
TI Negative pressure wound therapy in reconstructing extensive leg and foot
   soft tissue loss in a child: a case study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE children; open fracture; negative pressure wound therapy; soft tissue
   loss; traumatic injury
ID VACUUM-ASSISTED CLOSURE; III OPEN FRACTURES; MANAGEMENT; TIBIA;
   IRRIGATION; DEVICE
AB Open fractures of the leg with large loss of tissue require extensive reconstructive methods that can injure the donor area. The use of negative pressure wound therapy (NPWT) may minimise the impact of these reconstructive methods because of its capacity to create granulation tissue that will form a wound bed for the skin graft, thus reducing the volume of soft tissue defect and saving the donor region. This case study describes the effectiveness of NPWT in the treatment and reconstruction of an open fracture of the leg, with massive loss of soft tissue, associated with elastic intramedullary nailing in a 10-year-old female patient, who was a victim of a car accident. Clinical examination revealed a Gustilo-Anderson IIIB open fracture of the left leg, with the avulsion of the fifth toe, disarticulation of the fifth metatarsal bone, extensively damaged skin and subcutaneous tissue in the medium and distal third of the left leg and left foot. The bone was exposed in the distal part of the leg, external malleolus and left calcaneus. Profuse lavage, reduction of the tibial fracture and elastic intramedullary nailing, amputation of the fifth left toe, necrectomy and debridement of devitalised tissue were performed. NPWT was started, with the dressing changed every five days. After 55 days of using NPWT, granulation tissue covered the soft tissue defect and created a wound bed for the skin graft.
   NPWT helped the management of this open wound, achieving a wound bed for the skin graft, avoiding the use of complex reconstructive methods.
C1 [Tevanov, Iulia; Carp, Madalina; Dusca, Andrei; Ulici, Alexandru] Emergency Hosp Children Grigore Alexandrescu, Dept Pediat Orthoped Surg, Bucharest, Romania.
   [Enescu, Dan Mircea] Emergency Hosp Children Grigore Alexandrescu, Dept Plast & Reconstruct Surg, Bucharest, Romania.
   [Enescu, Dan Mircea; Ladaru, Alin; Ulici, Alexandru] Carol Davila Univ Med & Pharm, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Ulici, A (通讯作者)，Emergency Hosp Children Grigore Alexandrescu, Dept Pediat Orthoped Surg, Bucharest, Romania.; Ulici, A (通讯作者)，Carol Davila Univ Med & Pharm, Bucharest, Romania.
EM alexandruulici@yahoo.com
RI Carp, Madalina/AAP-5790-2021; Ulici, Alexandru/AAM-8799-2021
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   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
   Sharar Sam R, 2012, Int J Crit Illn Inj Sci, V2, P111, DOI 10.4103/2229-5151.100886
   Singer Michael, 2015, Eplasty, V15, pe8
   Stafford PW, 2002, SURG CLIN N AM, V82, P273, DOI 10.1016/S0039-6109(02)00006-3
   Stewart DG Jr, 2005, J BONE JOINT SURG AM, V87A, P2784, DOI 10.2106/JBJS.E.00528
   Tevanov I, 2016, CHIRURGIA-BUCHAREST, V111, P175
   WILKINS J, 1991, ORTHOP CLIN N AM, V22, P433
NR 30
TC 8
Z9 8
U1 0
U2 7
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2018
VL 27
IS 6
SU S
BP S14
EP S19
DI 10.12968/jowc.2018.27.Sup6.S14
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GI7DH
UT WOS:000434662000003
PM 29883293
DA 2026-07-24
ER

PT J
AU Kim, YH
   Hwang, KT
   Kim, JT
   Kim, SW
AF Kim, Y. H.
   Hwang, K. T.
   Kim, J. T.
   Kim, S. W.
TI What is the ideal interval between dressing changes during negative
   pressure wound therapy for open traumatic fractures?
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; flap; open fracture; infection
ID VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES; DIABETIC FOOT ULCERS;
   CLINICAL-EXPERIENCE; INFECTION; COVERAGE; IIIB; FLAP
AB Objective: Negative pressure wound therapy (NPWT) is effective in infection control during treatment of severe open fractures. However frequent dressing changes during NPWT are costly and cause patient discomfort. If the interval between dressing changes could be extended, these problems would be reduced. In this article we compare the outcomes of open IIIB fractures with 3-day versus 7-day intervals between dressing changes.
   Method: Patients who sustained Gustilo IIIB open fractures were included. All underwent conventional orthopaedic fixation with delayed latissimus dorsi flap coverage. Group 1 had 3-day intervals between dressing changes and group 2 had 7-day intervals. The final outcomes in the two groups were analysed.
   Results: There were 38 patients in group 1 and 34 patients in group 2. Although the period between admission and final operation was similar in the two groups, the mean number of NPWT changes was 4.54 in 3 day in group 1 and 1.95 in group 2 (p<0.001). This led to a difference in NPWT-related costs; $341.26 in group 1 and $237.49 in group 2(p<0.001). There was no difference in the frequency of complications such as infection or non-union of fractures.
   Conclusion: NPWT is useful treatment option for open fractures, to bridge between initial debridement and final microsurgical tissue transfer. Considering patient comfort, the costs related to the NPWT, and the final flap results, a 7-day interval between changes of the NPWT is acceptable.
   Declaration of interest: The authors have no conflict of interest to declare.
C1 [Kim, Y. H.; Kim, J. T.] Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul 133791, South Korea.
   [Hwang, K. T.] Hanyang Univ, Dept Orthoped Surg, Coll Med, Seoul 133791, South Korea.
   [Kim, S. W.] Seoul Natl Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul Natl Univ Hosp, Seoul, South Korea.
C3 Hanyang University; Hanyang University; Seoul National University (SNU);
   Seoul National University Hospital
RP Kim, YH (通讯作者)，Hanyang Univ, Dept Plast & Reconstruct Surg, Coll Med, Seoul 133791, South Korea.
EM sw1215@snu.ac.kr
RI ; Hwang, Kyu/R-7249-2016
OI Kim, Sang Wha/0000-0003-0430-3458; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 18
Z9 21
U1 0
U2 12
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2015
VL 24
IS 11
BP 536
EP 542
DI 10.12968/jowc.2015.24.11.536
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CX7SN
UT WOS:000365902800007
PM 26551646
DA 2026-07-24
ER

PT J
AU Schmedes, GW
   Banks, CA
   Malin, BT
   Srinivas, PB
   Skoner, JM
AF Schmedes, Gregg W.
   Banks, Caroline A.
   Malin, Barry T.
   Srinivas, Pamela B.
   Skoner, Judith M.
TI Massive Flap Donor Sites and the Role of Negative Pressure Wound Therapy
SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY
LA English
DT Article
DE free flap donor site complications; negative pressure wound therapy;
   microvascular head and neck reconstruction; massive flap donor site
   defects; scapular free tissue transfer; latissimus myocutaneous free
   tissue transfer; reconstructive surgery
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; SURGICAL INCISIONS;
   RECONSTRUCTION; NECK; HEAD; COMPLICATIONS
AB Objective. Report our experience with negative pressure wound therapy (NPWT) applied to massive scapular and latissimus free flap donor sites, in the setting of microvascular reconstruction for extensive head and neck defects.
   Study Design. Retrospective case series with chart review.
   Setting. Tertiary academic referral center.
   Subjects and Methods. Retrospective review was conducted of all patients who underwent scapular or latissimus free tissue transfer by the senior author for head and neck reconstruction, over a 5-year period (2006-2011). In addition to NPWT details, comprehensive patient data were abstracted and compiled, including demographics, operative details, hospital stay, postoperative follow-up, and donor site complications.
   Results. Ninety-four patients underwent reconstruction of extensive postablative head and neck defects using either a scapular or latissimus free flap. Mean harvested flap skin paddle size was 140 cm(2). All donor sites were closed primarily. Fifty-two patients (55%) had NPWT applied over closed donor site incisions postoperatively. The other 42 patients (45%) received only conventional incision care. Major donor site complications occurred in 12% (n = 5) of the patients who did not undergo NPWT, as compared with a 6% (n = 3) complication rate among patients in the NPWT-treated group.
   Conclusion. This is the first study to examine NPWT in the postoperative treatment of closed high-tension wounds following scapular or latissimus dorsi harvest for reconstruction of extensive head and neck defects. Our results suggest that NPWT is a safe technique in the management of massive scapular and latissimus free flap harvest sites that may decrease associated major donor wound complications.
C1 [Schmedes, Gregg W.; Banks, Caroline A.; Malin, Barry T.; Skoner, Judith M.] Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, Charleston, SC 29425 USA.
   [Srinivas, Pamela B.] Med Univ S Carolina, Dept Therapeut Serv, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina
RP Skoner, JM (通讯作者)，Med Univ S Carolina, Dept Otolaryngol Head & Neck Surg, 135 Rutledge Ave,MSC 550, Charleston, SC 29425 USA.
EM skonerjm@musc.edu
CR Arcuri F, 2011, J CRANIOFAC SURG, V22, P2347, DOI [10.1097/SCS.0b013e318231e480, 10.1097/SCS.0b013e31820f7fac]
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NR 19
TC 20
Z9 25
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0194-5998
EI 1097-6817
J9 OTOLARYNG HEAD NECK
JI Otolaryngol. Head Neck Surg.
PD DEC
PY 2012
VL 147
IS 6
BP 1049
EP 1053
DI 10.1177/0194599812459015
PG 5
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA 081CH
UT WOS:000314293000011
PM 22949007
DA 2026-07-24
ER

PT J
AU Borgquist, O
   Gustafsson, L
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Gustafsson, Lotta
   Ingemansson, Richard
   Malmsjo, Malin
TI Micro- and Macromechanical Effects on the Wound Bed of Negative Pressure
   Wound Therapy Using Gauze and Foam
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE animal model; experimental surgery; negative pressure wound therapy;
   wound healing; wound contraction; macrodeformation; microdeformation
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE
AB Negative pressure wound therapy (NPWT) results in 2 types of tissue deformation, macrodeformation (ie, wound contraction) and microdeformation (ie, the interaction of tissue and dressing on a microscopic level). These effects have been delineated for one type of wound filler, foam, but not for gauze. The mechanical deformation initiates a signaling cascade which ultimately leads to wound healing. The aim of the present study was to examine the effect of gauze and foam on macro-and microdeformation during treatment with negative pressure.
   An in vivo porcine peripheral wound model was used. NPWT was applied for 72 hours at 0, -75, and -125 mm Hg, using either foam or gauze as wound filler. The mechanical effects of NPWT were examined by measuring the wound surface area reduction and by histologic analysis of the wound bed tissue.
   Similar degrees of wound contraction (macrodeformation) were seen during NPWT regardless if foam or gauze was used. After negative pressure had been discontinued, the wound stayed contracted. There was no difference in wound contraction between -75 and -125 mm Hg. Biopsies of the wound bed revealed a repeating pattern of wound surface undulations and small tissue blebs ("tissue mushrooms") were pulled into the pores of the foam dressing and the spaces between the threads in the gauze dressing (microdeformation). This pattern was obvious in wounds treated both with foam and gauze, at atmospheric pressure (0 mm Hg) as well as at subatmospheric pressures (-75 and -125 mm Hg).
   The degrees of micro-and macrodeformation of the wound bed are similar after NPWT regardless if foam or gauze is used as wound filler.
C1 [Borgquist, Ola; Gustafsson, Lotta; Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@gmail.com
RI ; Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Gustafsson,
   Lotta/0000-0002-9826-9133; Maljö, Malin/0000-0001-9849-9599; 
FU Ake-Wieberg Foundation; Magn. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lund; Swedish Medical
   Research Council; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Government; Swedish Hypertension Society; Prospera
FX Supported by the Ake-Wieberg Foundation, the Magn. Bergvall Foundation,
   the Swedish Medical Association, the Royal Physiographic Society in
   Lund, the Swedish Medical Research Council, the Crafoord Foundation, the
   Swedish Heart-Lung Foundation, the Swedish Government Grant for Clinical
   Research, the Swedish Hypertension Society, and Prospera.
CR AUSTAD ED, 1986, PLAST RECONSTR SURG, V78, P63, DOI 10.1097/00006534-198607000-00009
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NR 20
TC 87
Z9 103
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2010
VL 64
IS 6
BP 789
EP 793
DI 10.1097/SAP.0b013e3181ba578a
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 602CU
UT WOS:000278116900021
PM 20489409
DA 2026-07-24
ER

PT J
AU Birke-Sorensen, H
   Malmsjo, M
   Rome, P
   Hudson, D
   Krug, E
   Berg, L
   Bruhin, A
   Caravaggi, C
   Chariker, M
   Depoorter, M
   Dowsett, C
   Dunn, R
   Duteille, F
   Ferreira, F
   Martínez, JMF
   Grudzien, G
   Ichioka, S
   Ingemansson, R
   Jeffery, S
   Lee, C
   Vig, S
   Runkel, N
   Martin, R
   Smith, J
AF Birke-Sorensen, H.
   Malmsjo, M.
   Rome, P.
   Hudson, D.
   Krug, E.
   Berg, L.
   Bruhin, A.
   Caravaggi, C.
   Chariker, M.
   Depoorter, M.
   Dowsett, C.
   Dunn, R.
   Duteille, F.
   Ferreira, F.
   Francos Martinez, J. M.
   Grudzien, G.
   Ichioka, S.
   Ingemansson, R.
   Jeffery, S.
   Lee, C.
   Vig, S.
   Runkel, N.
   Martin, R.
   Smith, J.
CA Int Expert Panel Negative Pressure
TI Evidence-based recommendations for negative pressure wound therapy:
   Treatment variables (pressure levels, wound filler and contact layer) -
   Steps towards an international consensus
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy (NPWT); Recommendations; Systematic
   review; Consensus; NPWT wound-filler materials; Negative pressure level
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; BACTERIAL
   BIOBURDEN; COST-EFFECTIVENESS; RANDOMIZED-TRIAL; DRESSING CHANGES;
   INFECTED WOUNDS
AB Negative pressure wound therapy (NPWT) is becoming a commonplace treatment in many clinical settings. New devices and dressings are being introduced. Despite widespread adoption, there remains uncertainty regarding several aspects of NPWT use. To respond to these gaps, a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In a previous communication, we have reviewed the evidence base for the use of NPWT within trauma and reconstructive surgery. In this communication, we present results of the assessment of evidence relating to the different NPWT treatment variables: different wound fillers (principally foam and gauze); when to use a wound contact layer; different pressure settings; and the impact of NPWT on bacterial bioburden. Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence and drafting of the recommendations by a global expert panel.
   Evidence and recommendations were graded according to the Scottish Intercollegiate Guidelines Network (SIGN) classification system.
   In general, there is relatively weak evidence on which to base recommendations for any one NPWT treatment variable over another. Overall, 14 recommendations were developed: five for the choice of wound filler and wound contact layer, four for choice of pressure setting and five for use of NPWT in infected wounds. With respect to bioburden, evidence suggests that reduction of bacteria in wounds is not a major mode of action of NPWT. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
   [Runkel, N.] Univ Freiburg, D-7800 Freiburg, Germany.
   [Birke-Sorensen, H.] Hamlet Hosp, Aarhus, Denmark.
   [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, M.] Skane Univ Hosp, Lund, Sweden.
   [Rome, P.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [Rome, P.] Concord Hosp, Sydney, NSW, Australia.
   [Hudson, D.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Krug, E.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
   [Berg, L.] Kuopio Univ Hosp, Kuopio, Finland.
   [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Caravaggi, C.] Inst Clin Citta Studi Milan, Ctr Treatment Diabet Foot Pathol, Milan, Italy.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Depoorter, M.] Acad Hosp St Jan, Dept Plast & Reconstruct Surg, Brugge, Belgium.
   [Dowsett, C.] E London NHS Fdn Trust, Community Hlth Newham Directorate, London, England.
   [Dunn, R.] Univ Massachusetts, Sch Med, Div Plast Surg, Worcester, MA 01605 USA.
   [Dunn, R.] Mem Hlth Care, Worcester, MA USA.
   [Duteille, F.] Hop Hotel Dieu, Plast Aesthet & Reconstruct Surg Burn Unit, Nantes, France.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Francos Martinez, J. M.] Hosp Univ Bellvitge, Endocrine Surg Unit, Barcelona, Spain.
   [Grudzien, G.] John Paul 2 Hosp, Dept Cardiovasc Surg & Transplantol, Krakow, Poland.
   [Ichioka, S.] Saitama Med Univ, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Ingemansson, R.] Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Div, Lund, Sweden.
   [Jeffery, S.] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
   [Lee, C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lee, C.] St Marys Hosp, San Francisco, CA USA.
   [Vig, S.] Mayday Univ Hosp, London, England.
C3 University of Freiburg; Lund University; Lund University; Skane
   University Hospital; NSW Health; Royal Prince Alfred Hospital;
   University of Sydney; Concord Repatriation General Hospital; University
   of Cape Town; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Massachusetts System; University of Massachusetts
   Worcester; Nantes Universite; CHU de Nantes; University of Barcelona;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; Saitama Medical University; Lund University; Skane
   University Hospital; University of Birmingham; Royal Centre for Defence
   Medicine; University of California System; University of California San
   Francisco; Croydon University Hospital
RP Runkel, N (通讯作者)，Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
EM norbert.runkel@sbk-vs.de
RI jeffery, steven/A-5207-2013; Birke-Sørensen, Hanne/B-6733-2015
OI jeffery, steven/0000-0001-6587-5412; Ingemansson,
   Richard/0000-0001-7623-8953; Martin, Robin/0000-0002-9314-0437; Maljö,
   Malin/0000-0001-9849-9599; 
FU Smith Nephew
FX Authors Jenny Smith and Robin Martin are employees of Smith & Nephew.
   The International Expert Panel on Negative Pressure Wound Therapy
   (EP-NPWT) is funded by an unrestricted educational grant provided by
   Smith & Nephew. Where no further conflicts of interest are stated, none
   is known to exist. In addition to this funding, the following financial
   relationships exist:
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NR 122
TC 148
Z9 179
U1 0
U2 42
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD SEP
PY 2011
VL 64
SU 1
BP S1
EP S16
DI 10.1016/j.bjps.2011.06.001
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 835QI
UT WOS:000296050500001
PM 21868296
DA 2026-07-24
ER

PT J
AU Pawar, DRL
   Jeyapalina, S
   Hafer, K
   Bachus, KN
AF Pawar, Divya R. L.
   Jeyapalina, Sujee
   Hafer, Kelli
   Bachus, Kent N.
TI Influence of negative pressure wound therapy on peri-prosthetic tissue
   vascularization and inflammation around porous titanium percutaneous
   devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE percutaneous devices; negative pressure wound therapy; skin downgrowth;
   wound healing; peri-prosthetic tissue
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; SOFT-TISSUE;
   MACROPHAGE PHENOTYPE; SKIN; MODEL; ANGIOGENESIS; EXPRESSION; INTERFACE;
   MECHANISM
AB Negative Pressure Wound Therapy (NPWT) has been shown to limit downgrowth around percutaneous devices in a guinea pig model. However, the influence of NPWT on periprosthetic tissue characteristics leading to limited downgrowth is still unclear. In order to investigate this, 12 CD hairless rats were assigned into two groups, NPWT and Untreated (n = 6/group). Each animal was implanted with a porous coated titanium percutaneous device and was dressed with a gauze and semi-occlusive base dressing. Post-surgery, animals in the NPWT Group received a regimen of NPWT treatment (-70 to -90 mmHg). After 4 weeks, tissue was collected over the device and stained with CD31 and CD68 to quantify blood vessel density and inflammation, respectively. The device with the surrounding tissue was also collected to quantify downgrowth. NPWT treatment led to a 1.6-fold increase in blood vessel densities compared to untreated tissues (p < 0.05). NPWT treatment also resulted in half the downgrowth as the Untreated Group, although not statistically significant (p = 0.19). Additionally, the results showed a trend toward increased CD68 cell densities in the NPWT Group compared to the Untreated Group (p = 0.09). These findings suggest that NPWT may influence wound healing responses in percutaneous devices by increasing blood vessel densities, limiting downgrowth and potentially increasing inflammation. Overall, NPWT may enhance tissue vascularity around percutaneous devices, especially in patients with impaired wound healing. (c) 2019 Wiley Periodicals, Inc.
C1 [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, Orthopaed Ctr, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Hafer, Kelli; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Jeyapalina, Sujee] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84132 USA.
C3 US Department of Veterans Affairs; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Orthopaed Ctr, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM kent.bachus@va.gov
RI Bachus, Kent/KYO-7869-2024
FU Department of Orthopaedics, University of Utah School of Medicine, Salt
   Lake City, Utah; LS-Peery Program in Musculoskeletal Restoration, Salt
   Lake City, UT; US Army Medical Research and Materiel Command
   [W81XWH-15-C-0058]; United States Department of Veterans Affairs
   Rehabilitation Research and Development Service [I01RX001217,
   I01RX001246]
FX Contract grant sponsor: Department of Orthopaedics, University of Utah
   School of Medicine, Salt Lake City, UtahContract grant sponsor: LS-Peery
   Program in Musculoskeletal Restoration, Salt Lake City, UTContract grant
   sponsor: US Army Medical Research and Materiel Command; contract grant
   number: W81XWH-15-C-0058Contract grant sponsor: United States Department
   of Veterans Affairs Rehabilitation Research and Development Service;
   grant numbers: I01RX001217, I01RX001246
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NR 45
TC 6
Z9 6
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD AUG
PY 2019
VL 107
IS 6
BP 2091
EP 2101
DI 10.1002/jbm.b.34302
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA JD4VY
UT WOS:000489979100033
PM 30629801
OA Bronze
DA 2026-07-24
ER

PT J
AU Wang, JM
   Yang, Y
   Xing, WQ
   Xing, H
   Bai, Y
   Chang, ZQ
AF Wang, Jingming
   Yang, Yang
   Xing, Wenqiang
   Xing, Hao
   Bai, Yun
   Chang, Zhengqi
TI Safety and efficacy of negative pressure wound therapy in treating deep
   surgical site infection after lumbar surgery
SO INTERNATIONAL ORTHOPAEDICS
LA English
DT Article
DE Surgical site infection (SSI); Clinical outcome; Negative pressure wound
   therapy (NPWT); Spinal instrumentation
ID VACUUM-ASSISTED CLOSURE; POSTERIOR SPINAL-FUSION; RISK-FACTORS;
   POSTOPERATIVE INFECTIONS; INSTRUMENTATION; IRRIGATION; DRAINAGE
AB Purpose To evaluate the efficacy and safety of negative pressure wound therapy (NPWT) for post-operative deep surgical site infection (SSI) after posterior instrumented spinal surgery. Methods We retrospectively compared the clinical outcomes of NPWT with standard debridement for deep SSI after posterior instrumented spinal surgery from 2012 to 2020 in our department. The primary outcomes were peri-operative characteristics including positive organism results, duration of fever, and visual analogue scale (VAS) pain scores three days after re-operation. The secondary outcomes were post-operative characteristics including implant infection recurrence, implant retention rate, duration of hospitalization, and VAS at discharge. Pearson's chi-squared analysis (categorical) and Student's t test (continuous) were used to determine the differences. Results Thirty-four patients were included, of which 19 underwent NPWT, and 15 underwent standard debridement. Patients in the NPWT group all significantly improved primary outcomes including duration of fever after re-operation (0.95 +/- 1.13 vs 4.07 +/- 5.35, P = 0.001), positive organism results (14 of 19 vs 2 of 15, P < 0.01), and VAS at 3 days after re-operation (2.58 +/- 0.69 vs 3.40 +/- 1.06, P < 0.05). Patients in NPWT group exhibited significant decrease in implant infection recurrence (0 of 19 vs 5 of 15, P < 0.01), implant retention rate (19 of 19 vs 10 of 15, P < 0.01), duration of hospitalization (27.74 +/- 10.95 vs 37.67 +/- 13.67, P < 0.01). Conclusions NPWT is a feasible and safe treatment option for deep SSI after posterior instrumented spinal surgery.
C1 [Wang, Jingming; Yang, Yang; Xing, Wenqiang; Xing, Hao; Bai, Yun; Chang, Zhengqi] 960th Hosp PLA, Dept Orthoped, Shifan Rd, Jinan 250031, Peoples R China.
RP Chang, ZQ (通讯作者)，960th Hosp PLA, Dept Orthoped, Shifan Rd, Jinan 250031, Peoples R China.
EM 26766771@qq.com
RI Xing, Wenqiang/MBW-3134-2025; hao, xing/ACN-7926-2022; Wang,
   Jing-ming/JGW-2472-2023
OI Wang, Jing-ming/0000-0002-4499-2086
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NR 31
TC 17
Z9 19
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2695
EI 1432-5195
J9 INT ORTHOP
JI Int. Orthop.
PD NOV
PY 2022
VL 46
IS 11
BP 2629
EP 2635
DI 10.1007/s00264-022-05531-w
EA AUG 2022
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 5F7ZG
UT WOS:000836542200001
PM 35931831
DA 2026-07-24
ER

PT J
AU Nishii, K
   Nakajima, T
   Yamamoto, T
   Tanaka, K
   Sakairi, Y
   Wada, H
   Suzuki, H
   Yoshino, I
AF Nishii, Kai
   Nakajima, Takahiro
   Yamamoto, Takayoshi
   Tanaka, Kazuhisa
   Sakairi, Yuichi
   Wada, Hironobu
   Suzuki, Hidemi
   Yoshino, Ichiro
TI Management of thoracic empyema with broncho-pulmonary fistula in
   combination with negative-pressure wound therapy
SO GENERAL THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; NPWT; Thoracic empyema; Open-window
   thoracostomy
ID VACUUM-ASSISTED CLOSURE
AB Objective Intrathoracic negative-pressure wound therapy (NPWT) has been introduced as a novel therapeutic device for the management of empyema. NPWT is expected to reduce the empyema cavity more rapidly than standard treatments; however, no objective analysis of the function of NPWT has yet been conducted. The study objective was to evaluate the efficacy of NPWT in the management of thoracic empyema. Methods Ten patients with stage II or III thoracic empyema treated with NPWT were retrospectively analyzed. The volume of the empyema cavity was measured, and the volume change after the administration of NPWT was calculated. A comparison with the institutional historical controls was also performed. Results The patients had initially undergone fenestration of the chest wall for empyema, and eight had bronchopleural fistula and required procedures to close the fistula. The mean duration of NPWT was 71.1 days (4-190 days). The mean volume of the empyema cavity decreased from 230.2 ml (42.8-788.4 ml) to 78.5 ml (5.2-185.3 ml) by applying NPWT (P = 0.02), and the mean % decrease was 58.7% (0-87.9%). Ultimately, the empyema cavity was able to be cleaned in nine, including seven who were cured by subsequent thoracoplasty and two who were cured without thoracoplasty. The current study group had a tendency toward an early cure with less chest wall destruction, a less hospital stay after open window thoracotomy compared to historical control. Conclusions NPWT enables the effective volume reduction and cleaning of the empyema cavity and achieves an early cure and reduced destruction of the chest wall.
C1 [Nishii, Kai; Nakajima, Takahiro; Yamamoto, Takayoshi; Tanaka, Kazuhisa; Sakairi, Yuichi; Wada, Hironobu; Suzuki, Hidemi; Yoshino, Ichiro] Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan.
C3 Chiba University
RP Nakajima, T (通讯作者)，Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chuo Ku, 1-8-1 Inohana, Chiba, Chiba 2608670, Japan.
EM takahiro_nakajima@med.miyazaki-u.ac.jp
RI Ichiro, Yoshino/HCH-1137-2022; Suzuki, Hidemi/GVS-5642-2022; Nakajima,
   Takahiro/GRX-7909-2022
OI Suzuki, Hidemi/0000-0002-8983-433X; Nakajima,
   Takahiro/0000-0002-4937-5378
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NR 10
TC 13
Z9 15
U1 0
U2 4
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1863-6705
EI 1863-6713
J9 GEN THORAC CARDIOVAS
JI Gen. Thorac. Cardiovasc. Surg.
PD MAY
PY 2021
VL 69
IS 5
BP 843
EP 849
DI 10.1007/s11748-020-01554-5
EA JAN 2021
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA RP7LS
UT WOS:000604155500001
PM 33389593
DA 2026-07-24
ER

PT J
AU Borys, S
   Hohendorff, J
   Frankfurter, C
   Kiec-Wilk, B
   Malecki, MT
AF Borys, Sebastian
   Hohendorff, Jerzy
   Frankfurter, Claudia
   Kiec-Wilk, Beata
   Malecki, Maciej T.
TI Negative pressure wound therapy use in diabetic foot syndrome-from
   mechanisms of action to clinical practice
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE amputation; diabetic foot syndrome; foot ulcer; healing; NPWT
ID VACUUM-ASSISTED CLOSURE; MATRIX METALLOPROTEINASES; SUBATMOSPHERIC
   PRESSURE; IWGDF GUIDANCE; BACTERIAL LOAD; BLOOD-FLOW; ULCERS;
   CONTRACTION; GAUZE; FOAM
AB Background Diabetes and its complications constitute a rising medical challenge. Special attention should be given to diabetic foot syndrome (DFS) due to its high rate of associated amputation and mortality. Negative pressure wound therapy (NPWT) is a frequently used supportive modality in a diabetic foot with ulcerations (DFUs).
   Design Here, we reviewed the current knowledge concerning the tissue and molecular mechanisms of NPWT action with an emphasis on diabetes research followed by a summary of clinical DFU studies and practice guidelines.
   Results Negative pressure wound therapy action results in two types of tissue deformations-macrodeformation, such as wound contraction, and microdeformation occurring at microscopic level. Both of them stimulate a wound healing cascade including tissue granulation promotion, vessel proliferation, neoangiogenesis, epithelialization and excess extracellular fluid removal. On the molecular level, NPWT results in an alteration towards more pro-angiogenic and anti-inflammatory conditions. It increases expression of several key growth factors, including vascular endothelial growth factor and fibroblast growth factor 2, while expression of inflammatory cytokinesis reduced. The NPWT application also alters the presence and function of matrix metalloproteinases. Clinical studies in DFU patients showed a superiority of NPWT over standard therapy in terms of efficacy outcomes, primarily wound healing and amputation rate, without a rise in adverse events. International guidelines point to NPWT as an important adjuvant therapy in DFU whose use is expected to increase.
   Conclusions This current knowledge improves our understanding of NPWT action and its tailoring for application in diabetic patients. It may inform the development of new treatments for DFU.
C1 [Borys, Sebastian; Hohendorff, Jerzy; Kiec-Wilk, Beata; Malecki, Maciej T.] Jagiellonian Univ, Med Coll, Dept Metab Dis, Krakow, Poland.
   [Borys, Sebastian; Hohendorff, Jerzy; Kiec-Wilk, Beata; Malecki, Maciej T.] Univ Hosp, Dept Metab Dis, Krakow, Poland.
   [Frankfurter, Claudia] Univ Toronto, Fac Med, Toronto, ON, Canada.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Toronto
RP Malecki, MT (通讯作者)，Jagiellonian Univ, Med Coll, Dept Metab Dis, Krakow, Poland.
EM maciej.malecki@uj.edu.pl
RI Hohendorff, Jerzy/U-1857-2018
OI Hohendorff, Jerzy/0000-0003-1153-8669
FU National Science Centre in Poland [2013/11/B/NZ5/03298]
FX MTM was awarded a grant funded by the National Science Centre in Poland
   "Assessment of molecular mechanisms of negative pressure wound therapy
   in the treatment of neuropathic ulceration in diabetic foot syndrome"
   (Nr 2013/11/B/NZ5/03298).
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NR 64
TC 62
Z9 75
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD APR
PY 2019
VL 49
IS 4
AR e13067
DI 10.1111/eci.13067
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HQ6ZP
UT WOS:000462569100005
PM 30600541
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Bhardwaj, H
   Joshi, R
   Gupta, A
AF Bhardwaj, Harish
   Joshi, Renjil
   Gupta, Anshita
TI Updated Scenario on Negative Pressure Wound Therapy
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE negative pressure wound therapy; wound healing; vacuum-assisted closer
   (VAC); chronic wound
ID DRESSINGS
AB Negative pressure wound therapy (NPWT) is a widely used and effective treatment for managing complex wounds. This document discusses how NPWT can be used in wound care in an updated way. The updated scenario on NPWT provides a concise overview of the current state of NPWT and its implications in clinical practice. It highlights recent developments in NPWT, as well as the advancements in this field. As part of NPWT, vacuum-assisted closure is used and negative pressure is applied to the wound bed. It discusses the key components and mechanisms. In addition to improving wound healing, NPWT also reduces infection rates and improves patient comfort, among other benefits. In addition, this document discusses the specific indications and contraindications of NPWT, as well as the types of wounds that can be treated with NPWT, including diabetic foot ulcers, pressure ulcers, and traumatic wounds. The document emphasizes the importance of choosing patients appropriately and assessing wounds to ensure optimal outcomes. In addition, it provides evidence-based guidelines and clinical recommendations on NPWT. In addition to reviewing the latest research findings supporting NPWT in a variety of clinical settings, it also discusses randomized controlled trials and systematic reviews. In addition, it discusses the potential complications and challenges associated with NPWT, including pain, bleeding, and device malfunction. The purpose of this document is to shed light on the role of NPWT in wound care management by providing an updated scenario. NPWT can be incorporated into clinical practice by healthcare professionals if they understand its principles, benefits, indications, and limitations. Healthcare providers can optimize patient outcomes and improve wound healing in diverse patient populations by staying abreast of the latest advancements in NPWT.
C1 [Bhardwaj, Harish] Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, CG, India.
   [Joshi, Renjil] Rungta Coll Pharmaceut Sci & Res Bhilai, Kohka Kurud, Chhatisgarh, India.
   [Gupta, Anshita] Rungta Coll Pharmaceut Sci & Res Nandanvan, Raipur, Chhattisgarh, India.
C3 Pt. Ravishankar Shukla University
RP Bhardwaj, H (通讯作者)，Pt Ravishankar Shukla Univ, Univ Inst Pharm, Raipur 492010, CG, India.
EM harishbhardwaj808@gmail.com
RI Gupta Soni, Anshita/AAN-5226-2020; Bhardwaj, Harish/KPA-1383-2024
OI Gupta Soni, Anshita/0000-0002-9763-6915; Bhardwaj,
   Harish/0000-0001-5080-9471
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NR 31
TC 7
Z9 7
U1 1
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2026
VL 25
IS 2
BP 284
EP 292
DI 10.1177/15347346241228788
EA JUN 2026
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IF7KA
UT WOS:001157835200001
PM 38327069
DA 2026-07-24
ER

PT J
AU Campitielio, F
   Mancone, M
   Della Corte, A
   Guerniero, R
   Canonico, S
AF Campitielio, Ferdinando
   Mancone, Manfredi
   Della Corte, Angela
   Guerniero, Raffaella
   Canonico, Silvestro
TI Expanded negative pressure wound therapy in healing diabetic foot
   ulcers: a prospective randomised study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE diabetes; diabetic foot ulcer; dressing; infection; macrostrain;
   microstrain; negative-pressure wound therapy;
   reconstructive-regenerative surgery; ulcer; wound
ID VACUUM-ASSISTED CLOSURE; GENERAL-SURGERY; LAPAROTOMY; MANAGEMENT;
   INCISIONS; DEVICE; TRIAL; DEFORMATIONS; EFFICACY; DISEASE
AB Objective: This study aims to evaluate the benefits of treating diabetic foot ulcers (DFU) through a revised procedure using the mechanisms underlying negative pressure wound therapy (NPWT) in such a way as to achieve reduced and more evenly distributed lateral tension lines across the wound.
   Method: Patients with type 2 diabetes were assessed for elegibility. Included patients were divided randomly into two groups: the NPWT control group and the NPWT+ group. Patients in the NPWT control group were treated in the traditional manner: wounds were covered with foams shaped to fit the wound precisely. In the NPWT+ group, foams were shaped to fit the wound precisely, and an additional foam was then wrapped around the foot.
   Results: Some 85 patients were assessed for eligibility; 59 were randomised into two groups: 29 patients in the NPWT+ group and 30 patients in the NPWT group. The primary objective was median healing time (NPWT+ 19 days, interquartile ratio (IQR) 7.5; NPWT 33 days, IQR 16; p<0.00001), and complete wound healing at three weeks (NPWT+ 55.20%; NPWT 26.70%; p=0.02). Secondary endpoints included number of major amputations (none in either group) and number of infections (NPWT+ 3.44% of patients, NPWT 6.66% of patients; p=0.57).
   Conclusion: Our initial findings show that this treatment significantly reduced wound closure times and accelerated healing in DFUs. It also demonstrated promising improvements in healing rates, with no significant increase in wound complications.
C1 [Campitielio, Ferdinando; Mancone, Manfredi; Della Corte, Angela; Guerniero, Raffaella; Canonico, Silvestro] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, Naples, Campania, Italy.
C3 Universita della Campania Vanvitelli
RP Mancone, M (通讯作者)，Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, Naples, Campania, Italy.
EM manconemanfredi@gmail.com
RI MANCONE, MANFREDI/AAQ-7069-2020
OI MANCONE, MANFREDI/0000-0002-6443-5092
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NR 63
TC 24
Z9 25
U1 1
U2 20
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2021
VL 30
IS 2
BP 121
EP 129
DI 10.12968/jowc.2021.30.2.121
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QJ4TC
UT WOS:000619683500006
PM 33573486
DA 2026-07-24
ER

PT J
AU Liu, S
   He, CZ
   Cai, YT
   Xing, QP
   Guo, YZ
   Chen, ZL
   Su, JL
   Yang, LP
AF Liu, Si
   He, Chao-zhu
   Cai, Yan-ting
   Xing, Qiu-ping
   Guo, Ying-zhen
   Chen, Zhi-long
   Su, Ji-liang
   Yang, Li-ping
TI Evaluation of negative-pressure wound therapy for patients with diabetic
   foot ulcers: systematic review and meta-analysis
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Review
DE diabetic foot ulcers; negative-pressure wound therapy; complete wound
   closure; amputation; meta-analysis; cost-effectiveness
ID VACUUM-ASSISTED CLOSURE; AMPUTATION; MULTICENTER; DRESSINGS
AB Objectives: The aim of this study was to perform an updated systematic review and meta-analysis to assess the clinical efficacy, safety, and cost-effectiveness of negative-pressure wound therapy (NPWT) in the treatment of diabetic foot ulcers (DFUs).
   Methods: We searched the Cochrane Library, MEDLINE, EMBASE, Ovid, and Chinese Biological Medicine databases up to June 30, 2016. We also manually searched the articles from reference lists of the retrieved articles, which used the NPWT system in studies of vacuumassisted closure therapy. Studies were identified and selected, and two independent reviewers extracted data from the studies.
   Results: A total of eleven randomized controlled trials, which included a total of 1,044 patients, were selected from 691 identified studies. Compared with standard dressing changes, NPWT had a higher rate of complete healing of ulcers (relative risk, 1.48; 95% confidence interval [CI]: 1.24-1.76; P<0.001), shorter healing time (mean difference, -8.07; 95% CI: -13.70-2.45; P=0.005), greater reduction in ulcer area (mean difference, 12.18; 95% CI: 8.50-15.86; P<0.00001), greater reduction in ulcer depth (mean difference, 40.82; 95% CI: 35.97-45.67; P<0.00001), fewer amputations (relative risk, 0.31; 95% CI: 0.15-0.62; P=0.001), and no effect on the incidence of treatment-related adverse effects (relative risk, 1.12; 95% CI: 0.66-1.89; P=0.68). Meanwhile, many analyses showed that the NPWT was more cost-effective than standard dressing changes.
   Conclusion: These results indicate that NPWT is efficacious, safe, and cost-effective in treating DFUs.
C1 [Liu, Si; He, Chao-zhu; Cai, Yan-ting; Xing, Qiu-ping; Guo, Ying-zhen; Chen, Zhi-long; Su, Ji-liang] Nanchang Univ, Sch Nursing, Ba Yi Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Yang, Li-ping] Nanchang Univ, Affiliated Hosp 2, Dept Endocrinol, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP He, CZ (通讯作者)，Nanchang Univ, Sch Nursing, Ba Yi Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM 1028970010@qq.com
RI Liu, Si/POY-6077-2026
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NR 35
TC 117
Z9 140
U1 1
U2 35
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2017
VL 13
DI 10.2147/TCRM.S131193
PG 12
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA ES8JQ
UT WOS:000399803700002
PM 28458556
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lin, ZY
   Zhang, XL
   Chen, YJ
   Tian, Y
   Yang, X
   Zhao, ZM
AF Lin, Zhiyu
   Zhang, Xinling
   Chen, Yujie
   Tian, Yun
   Yang, Xin
   Zhao, Zhenmin
TI Negative pressure wound therapy for flap closed-incisions after
   3D-printed prosthesis implantation in patients with chronic
   osteomyelitis with soft tissue defects
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Chronic osteomyelitis; Closed-incision; Negative pressure wound therapy;
   Soft tissue defects
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; SURGERY; INFECTIONS; PERFUSION
AB BackgroundThe flap closed-incisions healing after 3D-printed prosthesis implantation in Chronic Osteomyelitis with Soft Tissue Defects (COSTD) is critical. This study aimed to explore the safety and effectiveness of Negative Pressure Wound Therapy (NPWT) in promoting flap closed-incisions healing.MethodsRetrospective analysis of clinical data was performed, including baseline, surgical and hospitalization information. The efficacy of NPWT was assessed by comparing the ASEPSIS scores, Visual Analogue Scale (VAS), Activity of Daily Living Scale (ADLS), and Lower Extremity Functional Scale (LEFS), as well as the major postoperative complications.ResultsThe study included 20 patients, 13 received conventional dressing (Control group) and 7 received NPWT treatment (NPWT group). These two groups exhibited a notable disparity in the distribution of ASEPSIS scores, and the median scores were 24 in Control group and 9 in NPWT group (p = 0.001). Eight patients in the Control group experienced major incisional complications, including 7 cases of exudation, 3 cases of infection, 2 cases of non-healing, and 1 case of dehiscence, while none were observed in the NPWT group (p = 0.015). The VAS, ADLS, and LEFS scores were significantly improved in the NPWT group compared to the Control group (p = 0.003, 0.017, and 0.043, respectively).ConclusionsThe study findings suggest that NPWT applied to the healing process of flap closed-incisions after 3D prosthesis implantation in patients with COSTD can reduce the occurrence of postoperative major complications and promote the recovery of lower limb function and daily activities, which should be recommended for clinical practice.
C1 [Lin, Zhiyu; Chen, Yujie; Yang, Xin; Zhao, Zhenmin] Peking Univ Third Hosp, Dept Plast Surg, 49 North Garden Rd, Beijing 100191, Peoples R China.
   [Zhang, Xinling] Beijing Hosp, Dept Plast Surg, Beijing, Peoples R China.
   [Tian, Yun] Peking Univ Third Hosp, Dept Orthopaed, 49 North Garden Rd, Beijing 100191, Peoples R China.
C3 Peking University; Beijing Hospital; Peking University
RP Yang, X; Zhao, ZM (通讯作者)，Peking Univ Third Hosp, Dept Plast Surg, 49 North Garden Rd, Beijing 100191, Peoples R China.
EM yangxin6@126.com; zzmbysy@sina.com
RI Tian, Yun/PHA-5748-2026; Zhao, Zhenmin/NCV-1162-2025
FU Not applicable.
FX Not applicable.
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NR 35
TC 6
Z9 6
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 19
PY 2023
VL 24
IS 1
AR 827
DI 10.1186/s12891-023-06970-1
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA X6ED8
UT WOS:001099353600002
PM 37858142
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Seidel, D
AF Seidel, Doerthe
CA SAWHI Study Grp
TI Ambulatory negative pressure wound therapy of subcutaneous abdominal
   wounds after surgery: results of the SAWHI randomized clinical trial
SO BMC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Outpatients; Ambulatory care; Abdomen;
   Wound healing
ID VACUUM-ASSISTED CLOSURE; SURGICAL SITE INFECTIONS; QUALITY-OF-LIFE;
   ECONOMIC BURDEN; CARE; GROIN; FEASIBILITY; ALGINATE
AB Background: The SAWHI study showed that negative pressure wound therapy (NPWT) reduced treatment time by 7.8 days and had a 20.2% higher wound closure rate, but required a 2.1-day longer hospital stay than conventional wound treatment (CWT). The majority of study participants began treatment in the hospital and were discharged within 42 days. Methods: As an add-on to a multicenter randomized clinical trial, selected aspects of hospital discharge, outpatient treatment continuation, and subsequent wound closure outcomes are compared between the treatment arms in patients with subcutaneous abdominal wound healing impairment after surgery without fascia dehiscence in the per protocol population. Results: Within 42 days, wound closure rates were higher for outpatients in the NPWT arm than for outpatients in the CWT arm (27 of 55 [49.1%]) for both outpatient continuation of NPWT (8 of 26 [30.8%]) and outpatient CWT after NPWT was finished (27 of 121 [22.3%]). Time to wound closure was shorter for outpatients in the NPWT arm (outpatient transfer with: NPWT Mean +/- standard error 28.8 +/- 8.0 days; CWT 28.9 +/- 9.5 days) than in the conventional treatment arm (30.4 +/- 8.0 days). Nevertheless, within 30 study sites with patient enrollment, outpatient NPWT was performed in only 20 study sites for 65 of 157 study participants in the treatment arm. Conclusions: Outpatient NPWT of postsurgical abdominal wounds with healing impairment is feasible and successful and should be encouraged whenever possible. Study site specific avoidance of outpatient NPWT emerges as an additional reason for the prolonged hospitalization time.
C1 [Seidel, Doerthe; SAWHI Study Grp] Witten Herdecke Univ, Inst Forsch Operativen Med, Cologne, Germany.
RP Seidel, D (通讯作者)，Witten Herdecke Univ, Inst Forsch Operativen Med, Cologne, Germany.
EM DoertheSeidel@gmx.de
FU Projekt DEAL; Manufacturer, Kinetic Concepts Incorporated, an Acelity
   company
FX Open Access funding enabled and organized by Projekt DEAL. The
   SAWHI-study was funded by the manufacturer, Kinetic Concepts
   Incorporated, an Acelity company, (now part of 3 M) which included the
   financing of personnel and material resources for planning, conduct,
   analysis and report of the study. In addition, the manufacturer provided
   the negative pressure wound therapy (NPWT ) (brand name: Vacuum Assisted
   Closure (V.A.C.) Therapy devices) and associated consumable supplies.
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NR 40
TC 4
Z9 4
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD DEC 12
PY 2022
VL 22
IS 1
AR 425
DI 10.1186/s12893-022-01863-x
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 6Z4HU
UT WOS:000897740600002
PM 36503505
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Li, ZR
   Yu, QW
   Wang, S
   Wang, GQ
   Li, TT
   Tang, PF
   Liu, DH
AF Li, Zhirui
   Yu, Qingwen
   Wang, Song
   Wang, Guoqi
   Li, Tongtong
   Tang, Pei-fu
   Liu, Daohong
TI Impact of negative-pressure wound therapy on bacterial behaviour and
   bioburden in a contaminated full-thickness wound
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE bioluminescent imaging; contamination; infection; negative-pressure
   wound therapy; wound management
ID VACUUM-ASSISTED CLOSURE; INFECTION; OUTCOMES; SYSTEM
AB The use of negative-pressure wound therapy (NPWT) has displayed significant clinical benefits in the healing of infected wounds. However, the effects of NPWT on bacterial colonisation and infection of traumatic wounds has been controversial. The aim of this study is to evaluate the impact of NPWT treatment in rabbits with a contaminated full-thickness wound on bacterial behaviour, including colony morphology, spatial distribution, fissional proliferation, and bacterial bioburden. Full-thickness wounds were created on the back of rabbits, and were inoculated with bioluminescent Staphylococcus aureus. The wounds were treated with sterile gauze dressings and NPWT with continuous negative pressure (-125 mm Hg). Wound samples were harvested on days 0 (6 hours after bacterial inoculation), 2, 4, 6, and 8 at the centre of wound beds before irrigation. Scanning electron microscopy and transmission electron microscopy (TEM) analyses were performed to determine the characteristic bacteriology. Laser scanning confocal microscopy was performed to obtain bioluminescent images, which were used to observe spatial distribution of the GFP-labelled S. aureus within the tissue and quantify the bacterial bioburden. NPWT resulted in sparse amounts of scattered bacteria on the wound surface or as sparsely spaced single colonies within the tissue. Wound bioburden on day 8 in the NPWT and gauze groups was 34.6 +/- 5.5% and 141.9 +/- 15.4% of the baseline values (N = 6), respectively (P < .0001). TEM showed a lack of S. aureus active fission within NPWT-treated tissue. NPWT can impact S. aureus colony morphology and spatial distribution both on the surface and within wound tissue, and reduce S. aureus as early as 48 hours after therapy initiation. Additionally, NPWT inhibits bacterial fissional proliferation in microcolonies.
C1 [Li, Zhirui; Wang, Guoqi; Tang, Pei-fu] Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.
   [Li, Zhirui] Chinese Peoples Liberat Army Gen Hosp, Dept Orthoped, Sanya, Peoples R China.
   [Li, Zhirui] Hainan Branch, Sanya, Peoples R China.
   [Yu, Qingwen; Liu, Daohong] PLA, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
   [Wang, Song] Nankai Univ, Coll Med, Tianjin, Peoples R China.
   [Li, Tongtong] Tianjin Hosp, Dept Orthoped, Tianjin, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Nankai University; Tianjin University
RP Tang, PF (通讯作者)，Peoples Liberat Army, Dept Orthoped, Gen Hosp, Beijing 100853, Peoples R China.; Liu, DH (通讯作者)，PLA, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
EM pftang301@163.com; domb@vip.sina.com
RI Li, Zhirui/OJT-0490-2025
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NR 24
TC 16
Z9 19
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2019
VL 16
IS 5
BP 1214
EP 1221
DI 10.1111/iwj.13197
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA JG7RQ
UT WOS:000492273200018
PM 31483575
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kantak, NA
   Mistry, R
   Halvorson, EG
AF Kantak, Neelesh A.
   Mistry, Riyam
   Halvorson, Eric G.
TI A review of negative-pressure wound therapy in the management of burn
   wounds
SO BURNS
LA English
DT Review
DE Negative pressure wound therapy; Burns; Skin grafts; Dermal substitutes;
   VAC
ID VACUUM-ASSISTED CLOSURE; THICKNESS SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   DONOR SITE; DRESSINGS; TRIAL; PROGRESSION; INTEGRA; SYSTEM; DEVICE
AB Objective: Negative pressure has been employed in various aspects of burn care and the aim of this study was to evaluate the evidence for each of those uses.
   Methods: The PubMed and Cochrane CENTRAL databases were queried for articles in the following areas: negative pressure as a dressing for acute burns, intermediate treatment prior to skin grafting, bolster for skin autografts, dressing for integration of dermal substitutes, dressing for skin graft donor sites, and integrated dressing in large burns.
   Results: Fifteen studies met our inclusion criteria. One study showed negative pressure wound therapy improved perfusion in acute partial-thickness burns, 8 out of 9 studies showed benefits when used as a skin graft bolster dressing, 1 out of 2 studies showed improved rate of revascularization when used over dermal substitutes, and 1 study showed increased rate of re-epithelialization when used over skin graft donor sites.
   Conclusions: Negative pressure can improve autograft take when used as a bolster dressing. There is limited data to suggest that it may also improve the rate of revascularization of dermal substitutes and promote re-epithelialization of skin graft donor sites. Other uses suggested by studies that did not meet our inclusion criteria include improving vascularity in acute partial-thickness burns and as an integrated dressing for the management of large burns. Further studies are warranted for most clinical applications to establish negative pressure as an effective adjunct in burn wound care. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
C1 [Kantak, Neelesh A.] Harvard Combined Residency Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Mistry, Riyam] Univ Bristol, Sch Med, Senate House,Tyndall Ave, Bristol, Avon, England.
   [Halvorson, Eric G.] Brigham & Womens Hosp, Div Plast & Reconstruct Surg, 75 Francis St, Boston, MA 02115 USA.
C3 University of Bristol; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Halvorson, EG (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM ehalvorson@partners.org
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NR 36
TC 35
Z9 50
U1 2
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD DEC
PY 2016
VL 42
IS 8
BP 1623
EP 1633
DI 10.1016/j.burns.2016.06.011
PG 11
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA EG5HC
UT WOS:000391073900001
PM 27378361
DA 2026-07-24
ER

PT J
AU Nolff, MC
   Fehr, M
   Bolling, A
   Dening, R
   Kramer, S
   Reese, S
   Meyer-Lindenberg, A
AF Nolff, M. C.
   Fehr, M.
   Bolling, A.
   Dening, R.
   Kramer, S.
   Reese, S.
   Meyer-Lindenberg, A.
TI Negative pressure wound therapy, silver coated foam dressing and
   conventional bandages in open wound treatment in dogs
SO VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
LA English
DT Article
DE Negative pressure wound therapy; foam dressing; bacterial wound
   contamination; open wound management; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; SEPTIC PERITONITIS; MANAGEMENT; SKIN; VIABILITY
AB Objectives: To evaluate negative pressure wound therapy (NPWT) for treatment of complicated wounds in dogs.
   Study type: Retrospective multicentre study.
   Materials and methods: Dogs (n = 50) undergoing open wound treatment were classified according to treatment method used: bandage (Group A, n = 7), NPWT (Group B, n = 18), and foam dressing (Group C, n = 25). Pairs of patients matched based on wound conformation, localization, and underlying cause were compared between Group A and C (n = 7 pairs) and between groups B and C (n = 18 pairs) in terms of duration of previous treatment, time to closure, and complications.
   Results: Signalment, antibiotic medications, antiseptic treatment, and bacterial status of wounds were comparable between groups. The duration of previous treatment was significantly higher in patients assigned to Group B (p = 0.04) compared to Group C, while no significant difference was found between groups A and B. Total time to wound closure was significantly shorter in Group C compared to Group A (p = 0.02) and in Group B compared to Group C (p = 0.003). Wounds treated with NPWT suffered significantly less complications (p = 0.008) and were significantly less septic during treatment (p = 0.016) than wounds treated with a foam dressing.
   Conclusion: This study shows that time to healing was halved in NPWT treated patients compared to foam dressing treated patients, which in turn healed faster than patients treated with conventional bandage, underlining the value of NPWT therapy for the treatment of complicated wounds.
C1 [Nolff, M. C.; Meyer-Lindenberg, A.] Univ Munich, Clin Small Anim Surg & Reprod, D-80539 Munich, Germany.
   [Fehr, M.; Bolling, A.; Dening, R.; Kramer, S.] Univ Vet Med Hanover, Small Anim Clin, Hannover, NH, Germany.
   [Reese, S.] Univ Munich, Dept Vet Basic Sci, D-80539 Munich, Germany.
C3 University of Munich; University of Veterinary Medicine Hannover;
   University of Munich
RP Nolff, MC (通讯作者)，Univ Munich, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Reese, Sven/F-1826-2016; Nolff, Mirja/W-6756-2019; Meyer-Lindenberg,
   Andrea/H-1076-2011
OI Reese, Sven/0000-0002-4605-9791; Nolff, Mirja/0000-0001-9317-7769;
   Meyer-Lindenberg, Andrea/0000-0001-6137-3773
CR Amalsadvala T, 2006, VET CLIN N AM-SMALL, V36, P693, DOI 10.1016/j.cvsm.2006.02.002
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NR 38
TC 23
Z9 26
U1 1
U2 41
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0932-0814
EI 2567-6911
J9 VET COMP ORTHOPAED
JI Vet. Comp. Orthop. Traumatol.
PY 2015
VL 28
IS 1
BP 30
EP 38
DI 10.3415/VCOT-14-05-0076
PG 9
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA AZ8UK
UT WOS:000348489700007
PM 25449799
DA 2026-07-24
ER

PT J
AU Kim, BS
   Choi, WJ
   Baek, MK
   Kim, YS
   Lee, JW
AF Kim, Bom Soo
   Choi, Woo Jin
   Baek, Mi Kyung
   Kim, Yong Sang
   Lee, Jin Woo
TI Limb Salvage In Severe Diabetic Foot Infection
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE Diabetic Foot; Infection; Amputation; Limb Salvage; Negative Pressure
   Wound Therapy
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; AMPUTATION; ULCERS;
   RISK; MULTICENTER; VALIDATION
AB Background: The purpose of our study was to determine the efficacy of a management algorithm that includes negative pressure wound therapy (NPWT) in diabetic feet with limb-threatening infection. Materials and Methods: Forty-five septic diabetic feet were treated with NPWT between 2006 and 2008. After emergent abscess evacuation, early vascular intervention was performed if necessary. Debridement, with or without partial foot amputation, was followed by NPWT. Wound progress was measured using a digital scanner. A limb was considered salvaged if complete healing was achieved without any or with minor amputation through or below the ankle. The mean followup after complete wound healing was 17 (range, 6 to 35) months. Results: Thirty-two cases (71%) were infected with two or more organisms. Negative pressure wound therapy was applied for 26.2 +/- 14.3 days. The median time to achieve more than 75% wound area granulation was 23 (range, 4 to 55) days and 104 (range, 38 to 255) days to complete wound healing. Successful limb salvage was achieved in 44 cases (98%); 14 (31%) without any amputation and 30 (67%) with partial foot amputations. Total number of operations per limb was 2.4 +/- 1.3. One case of repeated infection and necrosis was managed with a transtibial amputation. There were no complications associated with NPWT. Conclusion: This study provides the outcome of a management algorithm which includes NPWT in salvaging severely infected diabetic feet. With emergent evacuation of abscess, early vascular intervention and appropriate debridement, NPWT can be a useful adjunct to the management of limb-threatening diabetic foot infections.
C1 [Lee, Jin Woo] Yonsei Univ, Coll Med, Dept Orthopaed Surg, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, JW (通讯作者)，Yonsei Univ, Coll Med, Dept Orthopaed Surg, 250 Seongsan No, Seoul 120752, South Korea.
EM ljwos@yuhs.ac
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NR 23
TC 19
Z9 24
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JAN
PY 2011
VL 32
IS 1
BP 31
EP 37
DI 10.3113/FAI.2011.0031
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 703NR
UT WOS:000285986000006
PM 21288432
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Sahin, U
   Demiröz, A
   Sahin, S
   Arslan, H
AF Sahin, Ugur
   Demiroz, Anil
   Sahin, Songul
   Arslan, Hakan
TI Effects of negative pressure wound therapy on an axial congested rabbit
   skin flap model without any bare surface
SO JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacum asisted closure; venous skin
   flap; congested flap; axial skin flap; flaps; plastic surgery
ID VACUUM-ASSISTED CLOSURE; VENOUS CONGESTION; SALVAGE; HEPARIN
AB One of the most important problems encountered in reconstructive surgery is partial or total flap loss, and venous congestion is the most common reason. It should be solved as early as possible. The purpose of this study is to investigate the effects of Negative pressure wound therapy (NPWT) on an ideal congested rabbit skin flap model without any open wound. The current study included 28 female, adult, New Zealand albino rabbits. Animals were divided into four groups according to the duration of NPWT to be applied. An axial pattern ideal congested skin flap was designed on the posterior surface of the ear. After surgical intervention on the right ears, we applied NPWT treatment for 2, 4, 6 and 8 days. The left ears were followed without any treatment. Samples were taken for edema, congestion and neo-angiogenesis examination. There was no significant difference between the NPWT applied group and control group in the 2nd, 4th, 6th, and 8th days for edema and neo-angiogenesis and no differences in the 2nd, 6th, and 8th days for congestion. NPWT group had a higher flap survival rate than the control group but without a significant difference. This study used an ideal congested rabbit skin flap model imitating venous congestion. Our findings illustrate that NPWT treatment does not have a significant effect on the congested skin flap model we utilized where a closed system was created maintaining a skin barrier without a bare surface of the flap.
C1 [Sahin, Ugur; Demiroz, Anil; Arslan, Hakan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Plast Reconstruct & Aesthet Surg Dept, Istanbul, Turkey.
   [Sahin, Songul] Cankiri State Hosp, Pathol Dept, Cankiri, Turkey.
C3 Istanbul University - Cerrahpasa; Cankiri State Hospital
RP Arslan, H (通讯作者)，Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Plast Reconstruct & Aesthet Surg Dept, Istanbul, Turkey.
EM hakanarsln93@gmail.com
RI Demiroz, Anil/C-9553-2019; Arslan, Hakan/A-1770-2017; sahin,
   songul/OJU-6309-2025; Sahin, Ugur/L-4818-2017
OI Demiroz, Anil/0000-0001-6182-6939; Arslan, Hakan/0000-0001-8838-8262; 
FU Istanbul University Scientific Research Projects Committee [52419]
FX This study was financially supported by the Istanbul University
   Scientific Research Projects Committee [Project ID: 52419].
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NR 18
TC 2
Z9 2
U1 0
U2 2
PU Medical Journal Sweden AB
PI Uppsala
PA Kungsngsvgen 27St, Uppsala, SWEDEN
SN 2000-656X
EI 2000-6764
J9 J PLAST SURG HAND SU
JI J. Plast. Surg. Hand Surg.
PD APR 1
PY 2022
VL 56
IS 2
BP 115
EP 120
DI 10.1080/2000656X.2021.1934847
EA JUN 2021
PG 6
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 0K4AX
UT WOS:000659387800001
PM 34106810
OA gold
DA 2026-07-24
ER

PT J
AU Borejsza-Wysocki, M
   Bobkiewicz, A
   Francuzik, W
   Krokowicz, L
   Walczak, D
   Szmeja, J
   Banasiewicz, T
AF Borejsza-Wysocki, Maciej
   Bobkiewicz, Adam
   Francuzik, Wojciech
   Krokowicz, Lukasz
   Walczak, Dominik
   Szmeja, Jacek
   Banasiewicz, Tomasz
TI Effect of closed incision negative pressure wound therapy on incidence
   rate of surgical site infection after stoma reversal: a pilot study
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE closed incision negative pressure wound therapy; stoma reversal;
   surgical site infection
ID VACUUM-ASSISTED CLOSURE; ILEOSTOMY CLOSURE; SKIN CLOSURE; PROTECTIVE
   ILEOSTOMY; PURSESTRING CLOSURE; MANAGEMENT-SYSTEM; RISK; PREVENTION;
   COMPLICATIONS; COLOSTOMY
AB Introduction: The stoma reversal (SR) procedure is associated with a relatively high risk of perioperative complications with surgical site infection (SSI) as the most common. Recently closed incision negative pressure wound therapy (ciNPWT) was applied widely to prevent SSI. Aim: To investigate the efficiency of ciNPWT in terms of the incidence rate of SSI after SR surgery. Material and methods: As an exploratory observational cohort study patients were treated either with ciNPWT (n = 15) or standard sterile dressing (SSD) (n = 15). CiNPWT was applied every 3 days whereas SSD was changed every day. Clinical evaluation for SSI signs, C-reactive protein level and pain assessment using the visual analogue scale (VAS) were analyzed. Results: The incidence rate of SSI was in 13% (2/15) in the ciNPWT group and 26% (4/15) in the SSD group (p = 0.651, OR = 0.44, 95% CI: 0.03-3.73). All patients in the SSD group who developed SSI presented both local and generalized signs of infection. Pain-VAS levels assessed on the 1st (MdnciNPWT = 4, MdnSSD = 5, p = 0.027, W = 51.5) and 3rd postoperative day (MdnciNPWT = 2, MdnSSD = 4, p = 0.014, W = 45.5) were significantly lower in the ciNPWT group than in the SSD group. Conclusions: CiNPWT seems not to have a benefit to reduce SSI after the SR procedure. Further investigation is needed to establish firmly the benefit of using ciNPWT in this group of patients.
C1 [Borejsza-Wysocki, Maciej; Bobkiewicz, Adam; Krokowicz, Lukasz; Szmeja, Jacek; Banasiewicz, Tomasz] Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Poznan, Poland.
   [Francuzik, Wojciech] Charite, Dept Dermatol Venerol & Allergol, Berlin, Germany.
   [Walczak, Dominik] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Ontol & Reconstruct Surg, Gliwice, Poland.
C3 Poznan University of Medical Sciences; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Bobkiewicz, A (通讯作者)，Poznan Univ Med Sci, Dept Gen Endocrinol & Gastroenterol Oncol Surg, Poznan, Poland.
EM bobofon007@gmail.com
RI Francuzik, Wojciech/H-6773-2019
OI Francuzik, Wojciech/0000-0001-5361-9876
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NR 49
TC 18
Z9 20
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2021
VL 16
IS 4
BP 686
EP 696
DI 10.5114/wiitm.2021.106426
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XN9JW
UT WOS:000729814600007
PM 34950263
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Qiu, XG
   Wu, YF
   Zhang, D
   Zhang, H
   Yu, AX
   Li, ZH
AF Qiu, Xingan
   Wu, Yifan
   Zhang, Dong
   Zhang, Hao
   Yu, Aixi
   Li, Zonghuan
TI Roles of Oxidative Stress and Raftlin in Wound Healing Under
   Negative-Pressure Wound Therapy
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Article
DE SOD; CAT; MDA; Raftlin; negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; LIPID RAFT; PROTEIN; COMPLICATIONS;
   INFLAMMATION; INJURIES; BURDEN; OXYGEN
AB Background: Negative-pressure wound therapy (NPWT) is an effective way to promote wound healing. However, its mechanisms have not been investigated thoroughly. Growing evidence suggests that oxidative stress and Raftlin levels play important roles in wound healing. However, whether NPWT promotes wound healing through this mechanism remains unclear.
   Purpose: Our study focuses on the different levels of oxidative stress and antioxidant response between wounds treated by NPWT and routine dressing change. The objective of this study was to measure the differences in Raftlin levels between the two groups, which is a new biomarker related to wound healing.
   Methods: We divided 48 male Sprague-Dawley rats with identical full-thickness skin defects into two groups. At specific times (0, 3, 5, 7, 9, 11, and 13 days after surgery), wound tissue samples were obtained for immunohistochemistry and biochemical analysis. The expression of Raftlin and levels of oxidative stress, including malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured by biochemical analysis. Wound-healing times were also compared.
   Results: In the NPWT group, MDA levels were significantly decreased on days 3, 5, and 7. Furthermore, the expressions of SOD and CAT were significantly reduced on days 3 and 5. Our data also revealed that Raftlin was significantly upregulated across the whole period of wound healing. Moreover, wound healing in the NPWT group was significantly more rapid (16 days on average) than in the control group (24 days on average). On day 13 post surgery, the wound-healing percentage in the NPWT group was 91%, while that in the control group was 48%.
   Conclusion: NPWT may promote wound healing by upregulating Raftlin and inhibiting oxidative stress levels.
C1 [Qiu, Xingan; Wu, Yifan; Zhang, Dong; Zhang, Hao; Yu, Aixi; Li, Zonghuan] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX; Li, ZH (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped Trauma & Microsurg, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi@whu.edu.cn; lizonghuan@whu.edu.cn
FU Second Medical Leading Talents Project of Hubei Province [LJ20200405]
FX Y This study was supported by the Second Medical Leading Talents Project
   of Hubei Province (grant no. LJ20200405) .
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NR 42
TC 17
Z9 17
U1 0
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2021
VL 14
BP 1745
EP 1753
DI 10.2147/CCID.S334248
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA XB5KX
UT WOS:000721369200003
PM 34848985
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ikeno, Y
   Sakakibara, S
   Yokawa, K
   Kitani, K
   Nakai, H
   Yamanaka, K
   Inoue, T
   Tanaka, H
   Terashi, H
   Okita, Y
AF Ikeno, Yuki
   Sakakibara, Shunsuke
   Yokawa, Koki
   Kitani, Keitaro
   Nakai, Hidekazu
   Yamanaka, Katsuhiro
   Inoue, Takeshi
   Tanaka, Hiroshi
   Terashi, Hiroto
   Okita, Yutaka
TI Post-sternotomy deep wound infection following aortic surgery: wound
   care strategies to prevent prosthetic graft replacement
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Perioperative care (intraoperative care);
   Surgery; Complications; Negative pressure wound therapy; Continuous
   irrigation
ID VACUUM-ASSISTED CLOSURE; OMENTAL FLAP TRANSPOSITION; SURGICAL STRATEGY;
   RECONSTRUCTION; MEDIASTINITIS; IRRIGATION; COMPLICATIONS; MORTALITY;
   SURVIVAL
AB OBJECTIVES: The aim of this study was to evaluate the early and long-term outcomes of our multidisciplinary strategy for treating deep sternal wound infection after aortic grafting, which consisted of debridement by a plastic surgeon, negative pressure wound therapy with continuous irrigation and chest wall reconstruction.
   METHODS: We performed a retrospective analysis of 18 patients who had a deep sternal wound infection following aortic grafting through a median sternotomy between January 2009 and December 2017. All patients had organisms cultured from mediastinal tissue within 2 months from the initial aortic surgery. The prosthetic grafts were exposed in 15 patients during resternotomy. Our protocol involved repeat debridement and negative pressure wound therapy with continuous irrigation twice a week until the results of the culture were negative and chest wall reconstruction was complete.
   RESULTS: The mean duration from primary aortic surgery to resternotomy was 23.7 +/- 15.9 days. Except for 1 patient, 17 patients underwent chest wall reconstruction. The mean duration from resternotomy to chest wall reconstruction was 31.1 +/- 28.0 days. The hospital mortality rate was 16.7% (3 patients), although no patients died of wound-related causes. The mean follow-up period was 2.9 +/- 2.5 years. Overall survival was 69.6 +/- 11.4% at 1 year and 54.2 +/- 13.3% at 5 years. Freedom from reoperation for reinfection was 94.4 +/- 5.4% at 5 years.
   CONCLUSIONS: Our wound care strategy achieved acceptable early and late survival in patients who had deep sternal wound infection following aortic grafting. This strategy may benefit those who experience this devastating complication.
C1 [Ikeno, Yuki; Yokawa, Koki; Nakai, Hidekazu; Yamanaka, Katsuhiro; Inoue, Takeshi; Tanaka, Hiroshi; Okita, Yutaka] Kobe Univ, Grad Sch Med, Dept Cardiovasc Surg, Kobe, Hyogo, Japan.
   [Sakakibara, Shunsuke; Kitani, Keitaro; Terashi, Hiroto] Kobe Univ, Grad Sch Med, Dept Plast Surg, Kobe, Hyogo, Japan.
C3 Kobe University; Kobe University
RP Okita, Y (通讯作者)，Kobe Univ, Grad Sch Med, Dept Surg, Div Cardiovasc Surg,Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM yutakaokita@gmail.com
RI Sakakibara, Shunsuke/JWP-3331-2024; Yokawa, Koki/OUJ-3462-2025
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NR 28
TC 10
Z9 12
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2019
VL 55
IS 5
BP 975
EP 982
DI 10.1093/ejcts/ezy389
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA IV2DK
UT WOS:000484087700026
PM 30544183
OA Bronze
DA 2026-07-24
ER

PT J
AU Blum, ML
   Esser, M
   Richardson, M
   Paul, E
   Rosenfeldt, FL
AF Blum, Martin L.
   Esser, Max
   Richardson, Martin
   Paul, Eldho
   Rosenfeldt, Franklin L.
TI Negative Pressure Wound Therapy Reduces Deep Infection Rate in Open
   Tibial Fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; open fractures; open tibial fractures;
   deep infection
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; LOWER-EXTREMITY TRAUMA;
   SHAFT FRACTURES; INTRAMEDULLARY NAILS; TEMPORARY TREATMENT;
   RANDOMIZED-TRIAL; MANAGEMENT; COMPLICATIONS; NONUNION
AB Objectives: To evaluate the effect of negative pressure wound therapy (NPWT) on deep infection rate in open tibial fractures.
   Design: Retrospective cohort study. Data was collected from medical records and radiographs.
   Setting: Two level-1 trauma centers.
   Patients/Participants: Patients who sustained an open tibial fracture which underwent delayed soft tissue coverage between January 2002 and December 2007 were included. Exclusion criteria included open fractures receiving a combination of NPWT and conventional dressings, fractures which were treated with a primary amputation, and fractures associated with mortality.
   Intervention: NPWT with reticulated open cell foam or conventional dressings at surgeon's discretion.
   Main Outcome Measurement: Deep infection rate.
   Results: A total of 229 open tibial fractures in 220 patients met the inclusion criteria and received either NPWT (166/229-72%) or conventional dressings (63/229-28%). There was a decreased rate of deep infection in the NPWT group compared with the conventional dressing group [8.4% (14/166) vs. 20.6%(13/63); P = 0.01]. Univariate predictors of deep infection included Gustilo type {odds ratio (OR): 3.13 [95% confidence interval (CI): 1.74-5.64]; P, 0.001} and use of NPWT [OR: 0.35 (95% CI: 0.16-0.80); P = 0.01]. When adjustment was performed for Gustilo type with multivariate analysis, use of NPWT was found to reduce the risk of deep infection by almost 80% [OR: 0.22 (95% CI: 0.09-0.55); P = 0.001].
   Conclusions: These results suggest that NPWT reduces the rate of deep infection when used for the dressing of traumatic wounds in open tibial fractures.
C1 [Blum, Martin L.; Rosenfeldt, Franklin L.] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia.
   [Blum, Martin L.] NTRI, Melbourne, Vic, Australia.
   [Blum, Martin L.; Rosenfeldt, Franklin L.] Alfred Hosp, Dept Surg, Melbourne, Vic, Australia.
   [Esser, Max] Alfred Hosp, Dept Orthopaed Surg, Melbourne, Vic, Australia.
   [Richardson, Martin] Royal Melbourne Hosp, Dept Orthopaed Surg, Melbourne, Vic, Australia.
   [Paul, Eldho] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
C3 Monash University; Florey Institute of Neuroscience & Mental Health;
   Howard Florey Institute Affiliates; Florey Institute of Neuroscience &
   Mental Health; Howard Florey Institute Affiliates; Melbourne Health;
   Royal Melbourne Hospital; Monash University
RP Blum, ML (通讯作者)，23-185 Barkly St, St Kilda, Vic 3182, Australia.
EM martyblum@hotmail.com
RI ; Richardson, Martin/H-2272-2018
OI Paul, Eldho/0000-0003-1263-7255; 
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NR 38
TC 80
Z9 94
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 499
EP 505
DI 10.1097/BOT.0b013e31824133e3
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200014
PM 22487900
DA 2026-07-24
ER

PT J
AU Andrews, E
   Bruwer, F
   Goosen, J
   Kairinos, N
   Laher, S
   Moeng, MS
   Ngcakani, A
   Ramdial, S
   Vadia, S
   Van Wyk, J
   Viljoen, JJ
   Weyers, DW
   Trivedi, S
AF Andrews, Ethel
   Bruwer, Febe
   Goosen, Jacques
   Kairinos, Nick
   Laher, Saadia
   Moeng, Maeyane S.
   Ngcakani, Anati
   Ramdial, Shaal
   Vadia, Suleman
   Van Wyk, Jacques
   Viljoen, Jacobus Jg
   Weyers, Deon W.
   Trivedi, Sadhana
TI Negative pressure wound therapy use: recommendations from a South
   African panel of experts
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE closed incision negative pressure therapy; negative pressure wound
   therapy; with instillation; panel recommendations; South Africa; wound;
   wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK PATIENTS; CARE; INSTILLATION;
   METAANALYSIS; COMORBIDITIES; COMPLICATIONS; PREVALENCE; DRESSINGS;
   STANDARD
AB Objective: The South African patient population is complex, with elevated traumatic injury rates and individuals living with multiple comorbidities. Healthcare provider and funding shortages, as well as wound care training not being a recognised subspecialty, have added to the burden of an already pressured South African healthcare system. With increases in non-specialist clinicians providing wound care, South Africa-specific wound care guidelines are needed. Method: An in-person meeting was held with wound care experts across South Africa to develop treatment recommendations for the use of negative pressure wound therapy (NPWT)-based systems. The publication panel convened on 8-9 December 2023 in Johannesburg, South Africa. The group of 14 panel members, including surgeons, wound care nurses and nurse practitioners, discussed clinical evidence regarding NPWT-based system use, followed by the development of a therapy-use algorithm. Results: Panel members recommended NPWT use for both simple/ low-risk and complex/large/high-risk wounds. NPWT with instillation and dwell time was recommended for both simple and complex wounds requiring cleansing. NPWT or closed incision negative pressure therapy use was recommended, as needed, following wound closure as per the reconstructive ladder. Conclusion: Limited published evidence supporting the use of NPWT-based systems exists for South Africa. These panel recommendations are a starting point and should be revised as more clinical evidence on NPWT-based system use within South Africa is published.
C1 [Andrews, Ethel] Univ Witwatersrand, Nursing Educ, Johannesburg, South Africa.
   [Bruwer, Febe] Life Roseacres Hosp, Adv Wound Care, Germiston, South Africa.
   [Goosen, Jacques; Moeng, Maeyane S.] Univ Witwatersrand, Sch Clin Med, Trauma Surg, Johannesburg, South Africa.
   [Goosen, Jacques] Netcare Alberton Hosp, Trauma Surg, Alberton, South Africa.
   [Kairinos, Nick] Univ Stellenbosch, Plast & Reconstruct Surg, Stellenbosch, South Africa.
   [Laher, Saadia] Netcare Alberton Hosp, Plast & Reconstruct Surg, Alberton, South Africa.
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   [Trivedi, Sadhana] Solventum, Med Surg, Dublin, Ireland.
C3 University of Witwatersrand; University of Witwatersrand; Stellenbosch
   University; University of Pretoria; Steve Biko Academy Hospital
RP Trivedi, S (通讯作者)，Solventum, Med Surg, Dublin, Ireland.
EM strivedi2@solventum.com
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NR 71
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2026
VL 35
IS 3
BP 221
EP 228
DI 10.12968/jowc.2025.0219
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA9ZG
UT WOS:001714450700001
PM 41805436
DA 2026-07-24
ER

PT J
AU Yu, GM
   Huang, XM
   Lin, RJ
   Zheng, SW
AF Yu, Genmiao
   Huang, Xiongmei
   Lin, Rongjia
   Zheng, Shengwu
TI Efficacy and safety of negative pressure wound therapy in the treatment
   of patients with cardiovascular implantable electronic devices pocket
   infection
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Negative-pressure wound therapy; Cardiac implantable electronic devices;
   Prosthesis-related infections; CIED pocket infection
ID TRANSVENOUS LEAD EXTRACTION; VACUUM-ASSISTED CLOSURE; ASSOCIATION;
   MICROBIOLOGY; MORTALITY; PACEMAKER; TRENDS; HRS
AB ObjectivesTo evaluate the efficacy of negative-pressure wound therapy (NPWT) for cardiac implantable electronic device (CIED) pocket infection, eliminating the need for CIED and leads extraction.MethodsThe NPWT cohort consisted of 42 patients with CIED infection who were treated with NPWT from 2013 to 2023. Among them, 3 patients had a systemic infection and 1 patient had incomplete data. We performed a case-control study in which the NPWT group was compared with the conservative treatment group (40 patients). Main outcomes included failure rate (CIED/lead extraction during the 1-year follow-up, 30-day mortality/chronic infection, or infection-related mortality/recurrence) and infection-free time, with cure defined as absence of failure criteria.ResultsA total of 38 patients with pocket infections were treated with NPWT from 2013 to 2023. NPWT was curative in 78.9% (n = 30 of 38) of patients who remained free of infection [median follow-up 12.63 months, interquartile range (IQR): 12.30-34.10 months]. Compared with patients who were treated conservatively, the two groups demonstrated balanced baseline characteristics. Patients who were treated with NPWT had a significantly higher cure rate (78.9% vs. 55.0%, n = 22 of 40; p = 0.025) and a longer mean infection-free time at the 1-year follow-up (338.00 vs. 285.20 days, p = 0.034).ConclusionNPWT is an effective alternative for patients with CIED pocket infections who are unsuitable or unwilling to undergo CIED and leads extraction.Trial registrationThis study was approved by the Chinese Clinical Trial Registry (Clinicaltrials.gov number: ChiCTR2300073560) on July 07, 2023.
C1 [Yu, Genmiao; Huang, Xiongmei; Zheng, Shengwu] Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Burn & Plast Surg, Fuzhou 350000, Peoples R China.
   [Yu, Genmiao; Huang, Xiongmei; Zheng, Shengwu] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350000, Peoples R China.
   [Lin, Rongjia] Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Thorac Surg, Fuzhou 350000, Peoples R China.
C3 Fuzhou University; Fujian Provincial Hospital; Fujian Medical
   University; Fuzhou University; Fujian Provincial Hospital
RP Zheng, SW (通讯作者)，Fuzhou Univ, Fujian Prov Hosp, Affiliated Prov Hosp, Dept Burn & Plast Surg, Fuzhou 350000, Peoples R China.; Zheng, SW (通讯作者)，Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350000, Peoples R China.
EM zhengshengwu_fjsl@126.com
RI Lin, Rongjia/NJS-2890-2025
OI Lin, Rongjia/0000-0002-8675-1387
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NR 41
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 23
PY 2025
VL 25
IS 1
AR 305
DI 10.1186/s12872-025-04769-7
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1UI3I
UT WOS:001473845800001
PM 40269780
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kawashima, K
   Esmaeili, A
AF Kawashima, Kazuho
   Esmaeili, Ali
TI Negative Pressure Wound Therapy in Free Flap Reconstruction: A
   Systematic Review and Meta-Analysis
SO MICROSURGERY
LA English
DT Review
DE free flaps; free tissue transfer; negative pressure wound therapy; VAC
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; LOWER-EXTREMITY;
   MICROSURGICAL RECONSTRUCTION; IMPLANTABLE DOPPLER; MUSCLE; MULTICENTER;
   EXPERIENCE; SALVAGE
AB Background Despite extensive research on negative pressure wound therapy (NPWT), its impact on immediate post-operative application in free flap reconstruction remains underexplored. The objective of this systematic review and meta-analysis is to evaluate the efficacy of NPWT compared with conventional wound therapy (CWT) in post-operative management of free flap, focusing on flap survival, complication rates, and flap size.Methods Searches were carried out in CENTRAL, Medline, and Embase. All prospective or retrospective clinical studies examining the effect of immediate post-operative application of NPWT after free flap reconstruction were considered for the review. No restrictions were placed on the date of publication but only papers written in English were included.Results 13 studies were included in the review, with 6 studies eligible for the meta-analysis. A total of 321 free flaps were included in the pooled analysis. NPWT reduced overall complication rates compared with CWT (OR 0.34, 95% CI 0.13 to 0.88, p = 0.03, n = 240) and also resulted in a statistically significant reduction in flap size (SMD -1.54, 95% CI -2.48 to -0.54, p = 0.002, n = 43). However, there was no significant difference in flap survival rates (OR 2.34, 95% CI 0.77 to 7.09, p = 0.13, n = 252).Conclusion NPWT appears to offer benefits over CWT in reducing complications and flap size, but precautions should be taken in interpreting these results. Further high-quality randomized controlled trials are required to validate these findings.
C1 [Kawashima, Kazuho] UCL, Div Surg & Intervent Sci, London, England.
   [Kawashima, Kazuho; Esmaeili, Ali] Royal Free NHS Fdn Trust, Dept Plast & Reconstruct Surg, London, England.
   [Esmaeili, Ali] Univ London, London, England.
C3 University of London; University College London; University of London
RP Kawashima, K (通讯作者)，UCL, Div Surg & Intervent Sci, London, England.; Kawashima, K (通讯作者)，Royal Free NHS Fdn Trust, Dept Plast & Reconstruct Surg, London, England.
EM kazuho.kawashima@nhs.net
OI Esmaeili, Ali/0009-0003-5280-2574; Kawahima, Kazuho/0009-0001-3436-6516
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NR 51
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0738-1085
EI 1098-2752
J9 MICROSURG
JI Microsurgery
PD NOV 19
PY 2025
VL 45
IS 8
AR e70144
DI 10.1002/micr.70144
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9YF8K
UT WOS:001617875500001
PM 41257533
DA 2026-07-24
ER

PT J
AU Chau, WW
   Lo, KCH
   Lau, LCM
   Ong, MTY
   Ho, KKW
AF Chau, Wai-Wang
   Lo, Kelvin Chin-Hei
   Lau, Lawrence Chun-Man
   Ong, Michael Tim-Yun
   Ho, Kevin Ki-Wai
TI Single use Negative Pressure Wound Therapy (NPWT) system in the
   management of knee arthroplasty
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Negative pressure wound therapy; Length of hospital stay; Skin blister
   formation; BMI
ID VACUUM-ASSISTED CLOSURE; FRACTURE SURGERY; TOTAL HIP; COMPLICATIONS;
   RISK; PREVENTION
AB BackgroundWound complication, skin blister formation in particular, causes devastating consequences after total knee arthroplasty (TKA). Negative Pressure Wound Therapy (NPWT) tries to improve wound management leading to decrease length of hospital stay and better clinical outcomes. Low body mass index (BMI) could play a part in wound recovery management although lacking evidence. This study compared length of hospital stay and clinical outcomes between NPWT and Conventional groups, and factors affected and how BMI affected.MethodsThis was a retrospective clinical record review of 255 (160 NPWT and 95 Conventional) patients between 2018 and 2022. Patient demographics including body mass index (BMI), surgical details (unilateral or bilateral), length of hospital stay, clinical outcomes including skin blisters occurrence, and major wound complications were investigated.ResultsMean age of patients at surgery was 69.95 (66.3% were female). Patients treated with NPWT stayed significantly longer in the hospital after joint replacement (5.18 days vs. 4.55 days; p = 0.01). Significantly fewer patients treated with NPWT found to have blisters (No blisters: 95.0% vs. 87.4%; p = 0.05). In patients with BMI < 30, percentage of patients requiring dressing change was significantly lower when treated with NPWT than conventional (0.8% vs. 33.3%).ConclusionPercentage of blisters occurrence in patients who underwent joint replacement surgery is significantly lower using NPWT. Patients using NPWT stayed significantly longer in the hospital after surgery because significant proportion received bilateral surgery. NPWT patients with BMI < 30 were significantly less likely to change wound dressing.
C1 [Chau, Wai-Wang; Lau, Lawrence Chun-Man; Ong, Michael Tim-Yun] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
   [Lo, Kelvin Chin-Hei] Alice Ho Miu Ling Nethersole Hosp, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China.
   [Ho, Kevin Ki-Wai] Chinese Univ Hong Kong Med Ctr, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Alice Ho Miu Ling Nethersole Hospital
RP Ho, KKW (通讯作者)，Chinese Univ Hong Kong Med Ctr, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
EM kevinho@cuhk.edu.hk
RI Ong, Michael Tim Yun/ADU-9207-2022; Ho, Kevin Ki Wai/J-7703-2018; Chau,
   Wai Wang/J-7907-2018; Lau, Lawrence Chun Man/AAJ-4908-2020
OI Ong, Michael Tim Yun/0000-0002-4460-9286; Ho, Kevin Ki
   Wai/0000-0001-8647-8475; Chau, Wai Wang/0000-0002-6973-1915; Lau,
   Lawrence Chun Man/0000-0002-2245-9627
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NR 35
TC 2
Z9 3
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD MAY 5
PY 2023
VL 24
IS 1
AR 351
DI 10.1186/s12891-023-06470-2
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA F6DK5
UT WOS:000983227800004
PM 37147702
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Zeng, JK
   Sun, XJ
   Sun, ZY
   Guan, J
   Han, C
   Zhao, X
   Zhang, P
   Xie, YZ
   Zhao, J
AF Zeng, Junkai
   Sun, Xiaojiang
   Sun, Zhenyu
   Guan, Jie
   Han, Chen
   Zhao, Xin
   Zhang, Pu
   Xie, Youzhuan
   Zhao, Jie
TI Negative Pressure Wound Therapy Versus Closed Suction Irrigation System
   in the Treatment of Deep Surgical Site Infection After Lumbar Surgery
SO WORLD NEUROSURGERY
LA English
DT Article
DE Closed suction irrigation system; Lumbar; Negative pressure wound
   therapy; Spine; Surgical site infection
ID POSTERIOR SPINAL-FUSION; VACUUM-ASSISTED-CLOSURE; RISK-FACTORS;
   INSTRUMENTATION; MANAGEMENT; RETENTION; IMPACT
AB OBJECTIVE: We compared the efficacy of a closed suction irrigation system (CSIS) and negative pressure wound therapy (NPWT) for deep surgical site infection (SSI) after lumbar surgery with instrumentation.
   METHODS: We included 31 patients (NPWT group, n =16; CSIS group, n = 15) with deep SS's after lumbar surgery with instrumentation from 2007 to 2017. The medical records were reviewed and patient characteristics, laboratory results, infection details, and treatment interventions were recorded. The Japanese Orthopaedic Association score and Oswestry disability index were used to assess pain and functional outcomes preoperatively and 3 and 12 months postoperatively. The cost of SSIs were compared between the NPWT and CSIS groups.
   RESULTS: No significant differences were found in the baseline characteristic data between the NPWT and CSIS groups. Implants were retained in all patients in the CSIS group, but required removal from 2 patients with late infections in the NPWT group. The average hospital stay was 36.8 +/- 10.5 days and 33.4 +/- 18.9 days in the NPWT and CSIS groups, respectively. The cost was greater in the NPWT group than in the CSIS group. Both NPWT and CSIS significantly reduced the Oswestry disability index and improved the Japanese Orthopaedic Association scores, but no significant difference was found between the 2 groups.
   CONCLUSIONS: Our results have shown that both NPWT and CSIS are efficient techniques for the management of deep SSI after lumbar surgery with instrumentation. CSIS was more economical and the NPWT system was portable and easier for postoperative nursing care.
C1 [Zeng, Junkai; Sun, Xiaojiang; Sun, Zhenyu; Guan, Jie; Han, Chen; Zhao, Xin; Zhang, Pu; Xie, Youzhuan; Zhao, Jie] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants, Sch Med,Dept Orthopaed Surg, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Xie, YZ (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants, Sch Med,Dept Orthopaed Surg, Shanghai, Peoples R China.
EM drxie_miss@163.com
RI Sun, Zhenyu/OVY-2476-2025
FU National Key Research and Development Program of China [2018YFC2002303];
   Ninth People's Hospital affiliated to Shanghai Jiao Tong University,
   School of Medicine "Multi-Disciplinary Team" Clinical Research Project
   [201701010]; Shanghai Clinical Medical Centre [2017ZZ01023]; Shanghai
   Municipal Key Clinical Specialty
FX The present study was supported by the National Key Research and
   Development Program of China (grant 2018YFC2002303), Ninth People's
   Hospital affiliated to Shanghai Jiao Tong University, School of Medicine
   "Multi-Disciplinary Team" Clinical Research Project (grant 201701010),
   Shanghai Clinical Medical Centre (grant 2017ZZ01023), and the Shanghai
   Municipal Key Clinical Specialty.
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NR 44
TC 27
Z9 33
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD JUL
PY 2019
VL 127
BP E389
EP E395
DI 10.1016/j.wneu.2019.03.130
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA IF5NH
UT WOS:000473128300048
PM 30905647
DA 2026-07-24
ER

PT J
AU Sogorski, A
   Lehnhardt, M
   Goertz, O
   Harati, K
   Kapalschinski, N
   Hirsch, T
   Daigeler, A
   Kolbenschlag, J
AF Sogorski, A.
   Lehnhardt, M.
   Goertz, O.
   Harati, K.
   Kapalschinski, N.
   Hirsch, T.
   Daigeler, A.
   Kolbenschlag, J.
TI Improvement of local microcirculation through intermittent Negative
   Pressure Wound Therapy (NPWT)
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Cutaneous microcirculation; Negative pressure wound therapy; NPWT;
   Tissue conditioning
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; LASER-DOPPLER;
   SHEAR-STRESS; ISCHEMIA; MECHANISMS; PERFUSION; PARADOX; INJURY; STATE
AB Background: Negative Pressure Wound Therapy (NPWT) is widely used across different kinds of surgical disciplines. A controversial debate was raised by diverging results from studies that were conducted to examine the impact of NPWT on local perfusion. Thus, there is a lack of evidence for one important underlying factors that influences the physiology of wound healing under an applied NPWT-dressing.
   Objective: To investigate the immediate local perfusion changes due to an applied intermittent NPWT protocol.
   Material and methods: A NPWT dressing was applied to the antero-lateral thigh of seven healthy volunteers with two probes of both pressure and microcirculatory measuring devices. One of each probe was placed under the NPWT dressing, the other one in close proximity next to it. A protocol consisting of two cycles of 10 min of -125 mmHg pressure, followed by 10 min of 0 mmHg pressure was applied. Measurements of local pressure to the underlying tissue, as well as microcirculatory changes were performed continuously.
   Results: Applied vacuum caused compressional forces (27.33 mmHg, p < 0.05) towards the underlying tissue. Blood Flow was increased after both suction periods (+52.5%, +108.7%; p < 0.05) and continued increasing until the end of measurements (+145.3%). This was accompanied by significant increase in Oxygen Saturation (+21.6%; p < 0.05) and Relative Hemoglobin Content (+16.7%). Red Blood Cell Velocity was found to be increased without statistical significance. Next to the dressing, changes were also significant but less pronounced.
   Conclusion: Intermittent NPWT improves local microcirculation with consecutive enhancement of oxygen supply.
C1 [Sogorski, A.; Lehnhardt, M.; Harati, K.; Kapalschinski, N.; Hirsch, T.] Ruhr Univ Bochum, BG Univ Hosp Bergmannsheil, Burn Ctr, Dept Plast Surg, Bochum, Germany.
   [Goertz, O.] Martin Luther Hosp, Dept Plast Reconstruct & Aesthet Surg, Hand Surg, Berlin, Germany.
   [Daigeler, A.; Kolbenschlag, J.] Eberhard Karl Univ, BG Trauma Ctr Tuebingen, Dept Hand Plast Reconstruct & Burn Surg, Schnarrenbergstr 95, D-72076 Tubingen, Germany.
C3 Ruhr University Bochum; Martin Luther University Halle Wittenberg;
   Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital
RP Kolbenschlag, J (通讯作者)，Eberhard Karl Univ, BG Trauma Ctr Tuebingen, Dept Hand Plast Reconstruct & Burn Surg, Schnarrenbergstr 95, D-72076 Tubingen, Germany.
EM Jonaskolbenschlag@gmail.com
RI Hirsch, Tobias/AAS-6707-2021; Daigeler, Adrien/C-9417-2016; Harati,
   Kamran/AHD-3426-2022
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NR 31
TC 32
Z9 42
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0965-206X
J9 J TISSUE VIABILITY
JI J. Viab.
PD NOV
PY 2018
VL 27
IS 4
BP 267
EP 273
DI 10.1016/j.jtv.2018.08.004
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA HG4SR
UT WOS:000454965800014
PM 30121158
DA 2026-07-24
ER

PT J
AU De Monti, M
   Cestaro, G
   Bertani, A
   Torre, A
   Fasolini, F
AF De Monti, Marco
   Cestaro, Giovanni
   Bertani, Annalisa
   Torre, Alessandro
   Fasolini, Fabrizio
TI Disposable negative-pressure wound therapy in outpatients: outcome
   comparison between electrically- and mechanically-powered devices
SO MINERVA BIOTECNOLOGICA
LA English
DT Article
DE Negative-pressure wound therapy; Wound healing; Ulcer
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; SYSTEM; ULCERS
AB BACKGROUND: Disposable negative-pressure wound therapy (NPWT) represents a useful tool to treat difficult healing skin defects in all outpatient setting. In this paper, authors performed a retrospective analysis regarding all patients treated with electrical or mechanical portable NPWT devices.
   METHODS: NPWT devices used from November 1st, 2015 to May 1st, 2018 have been considered, for a total of 72 treatments in 53 patients, average age 67 years (median age 73.7 years; IQR 53.8-86.7); all types of ulcers have been treated. The average duration of treatment was 17 days (median duration 14 days; IQR 7-27). We used one model of electrical devices at -125 mmHg (ED125) and two model of mechanical devices at -75 mmHg and -125 mmHg (MD75 and MD125). The type of dressing was identical in the three systems.
   RESULTS: In this series no statistical difference has been observed between mechanical and electrical devices (bivariate descriptive analysis with chi-squared or Fisher's Exact test) in terms of healing, lesion evolution, ability to prepare the wound bed for skin grafts or for the switch to advanced dressings. On the other hand, we have encountered significant difference (P=0.022) for the better ability of devices set at -125 to manage exudates.
   CONCLUSIONS: We believe that the choice of the device should be made by evaluating the amount of secretions, the possibility to obtain a good adhesion of the system and, primarily, the compliance of the patient. Both systems represent a valid support for the treatment of difficult healing wounds.
C1 [De Monti, Marco; Cestaro, Giovanni; Bertani, Annalisa; Torre, Alessandro; Fasolini, Fabrizio] EOC Beata Vergine Reg Hosp, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
RP De Monti, M (通讯作者)，EOC Beata Vergine Reg Hosp, Dept Gen Surg, Via Turconi 23, CH-6850 Mendrisio, Switzerland.
EM marco.demonti@eoc.ch
RI De Monti, Marco/HJI-5543-2023; Cestaro, Giovanni/AHE-2766-2022
OI De Monti, Marco/0000-0003-0927-3438; Cestaro,
   Giovanni/0000-0002-9091-0731
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong DG, 2012, WOUND REPAIR REGEN, V20, P332, DOI 10.1111/j.1524-475X.2012.00780.x
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   Morykwas MJ, 1999, J SURG ONCOL, V72, P14, DOI 10.1002/(SICI)1096-9098(199909)72:1<14::AID-JSO4>3.0.CO;2-3
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   von Gossler C M, 2000, J Cutan Med Surg, V4, P219
   Young SR, 2013, INT WOUND J, V10, P383, DOI 10.1111/j.1742-481X.2012.00994.x
NR 22
TC 0
Z9 0
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 1120-4826
EI 1827-160X
J9 MINERVA BIOTECNOL
JI Minerva Biotechnol.
PD MAR
PY 2020
VL 32
IS 1
BP 6
EP 12
DI 10.23736/S1120-4826.19.02584-9
PG 7
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA MT6QC
UT WOS:000555096400002
DA 2026-07-24
ER

PT J
AU Kamus, L
   Rameau, M
   Theoret, C
AF Kamus, Louis
   Rameau, Marie
   Theoret, Christine
TI Feasibility of a disposable canister-free negative-pressure wound
   therapy (NPWT) device for treating open wounds in horses
SO BMC VETERINARY RESEARCH
LA English
DT Article
DE Horse; Wound; Negative pressure wound therapy; Feasibility
ID VACUUM-ASSISTED CLOSURE; DISTAL EXTREMITY; SKIN-GRAFTS; MANAGEMENT; RISK
AB BackgroundWounds are among the most common medical conditions affecting horses and have a major economic impact on the horse industry. Wound healing in horses is distinct to that documented in other species, and often results in delayed healing and extensive scarring, with compromised functional and aesthetic outcomes. To date, there is no conventional method objectively proven to accelerate healing or to successfully prevent complications associated with second intention healing. Several effects of Negative Pressure Wound Therapy (NPWT) may be particularly useful to the management of wounds in horses. However, cumbersome designs of classic NPWT devices render them unsuitable for equine practice. A new lightweight, portable and disposable unit of NPWT (PICO (R)), should facilitate the use of this modality by equine practitioners. The aim of this study was to evaluate the feasibility of using this canister-free system to treat experimental open wounds in horses.ResultsNo difficulties were encountered with the application or maintenance of the PICO (R) system during the ex vivo experiment or during the preliminary in vivo experiment conducted on intact skin. All horses readily tolerated the PICO (R) but difficulties with adhesion and seal prevented the completion of the experimental wound study despite the use of many adjunctive adhesives.ConclusionThe current PICO (R) dressing design is not suitable to be used as a dressing for open wounds in horses though the device is well tolerated by equine patients. A dressing with a wider adhesive edge, a superior adhesive and a more flexible pad would likely be better adapted to enable its future use in equine practice.
C1 [Kamus, Louis; Rameau, Marie; Theoret, Christine] Univ Montreal, Dept Biomed Vet, 3200 Rue Sicotte, St Hyacinthe, PQ J2S 2M2, Canada.
C3 Universite de Montreal
RP Kamus, L (通讯作者)，Univ Montreal, Dept Biomed Vet, 3200 Rue Sicotte, St Hyacinthe, PQ J2S 2M2, Canada.
EM louis.j.kamus@umontreal.ca
RI /C-7320-2015; Kamus, Louis/ABY-4699-2022
OI Kamus, Louis/0000-0002-7192-3377
FU ACVS foundation [2881]
FX This study was partially supported by an unrestricted research grant
   from the ACVS foundation (#2881) and an in-kind donation from Smith &
   Nephew Canada. The funding has no role in the conception or execution of
   the study.
CR [Anonymous], 1999, EQUINE VET J
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   [No title captured]
NR 40
TC 10
Z9 11
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1746-6148
J9 BMC VET RES
JI BMC Vet. Res.
PD MAR 6
PY 2019
VL 15
AR 78
DI 10.1186/s12917-019-1829-5
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA HO3AZ
UT WOS:000460791600002
PM 30841889
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Glass, GE
   Murphy, GRF
   Nanchahal, J
AF Glass, Graeme E.
   Murphy, George R. F.
   Nanchahal, Jagdeep
TI Does negative-pressure wound therapy influence subjacent bacterial
   growth? A systematic review
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative-pressure wound therapy; NPWT; Bacterial bioburden;
   Non-fermentative gram-negative bacilli; Instillation therapy
ID VACUUM-ASSISTED CLOSURE; PSEUDOMONAS-AERUGINOSA; INSTILLATION;
   INFECTIONS; MANAGEMENT; BIOBURDEN; DRESSINGS
AB Background: Negative-pressure wound therapy is a ubiquitous wound management resource. The influence of NPWT on the bacterial bioburden of the subjacent wound remains unclear. We sought to examine the evidence.
   Datasources: MEDLINE, Embase, PubMed, the Cochrane Database of Systematic Reviews and the Cochrane Controlled Trials Register were searched for articles quantitatively evaluating bacterial load under NPWT.
   Results: Twenty-four studies met the inclusion criteria including 4 randomised controlled trials, 8 clinical series and 12 experimental studies. Twenty studies evaluated conventional NPWT, while 4 evaluated infiltration-based NPWT. While 8 studies using conventional NPWT failed to demonstrate an observable effect on bacterial load, 7 studies reported that NPWT was inherently bacteriostatic and 5 others reported species selectivity with suppression of non-fermentative gram-negative bacilli (NFGNB), including Pseudomonas spp. Simultaneously, there was some evidence of enhanced proliferation of gram-positive cocci where the niche was cleared of NFGNB. Two of the 4 studies using infiltration-based NPWT also reported selectively impaired proliferation of Pseudomonas spp.
   Conclusion: The assumption that NPWT suppresses bacterial proliferation is oversimplified. There is evidence that NPWT exhibits species selectivity, suppressing the proliferation of NFGNB. However, this may depopulate the niche for exploitation by gram-positive cocci. This, in turn, has implications for the use of NPWT where highly virulent strains of gram-positive cocci have been isolated and the duration of NPWT therapy and frequency of dressing changes. (C) 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Glass, Graeme E.; Nanchahal, Jagdeep] Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.
   [Glass, Graeme E.] Barts Hlth NHS Trust, Royal London Hosp, Whitechapel Rd, London, England.
   [Murphy, George R. F.] Univ Oxford, St Hughs Coll, Oxford, England.
C3 University of Oxford; Kennedy Institute for Rheumatology; Barts Health
   NHS Trust; Royal London Hospital; University of Oxford
RP Glass, GE (通讯作者)，Univ Oxford, Kennedy Inst Rheumatol, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Roosevelt Dr, Oxford OX3 7FY, England.
EM drgraemeglass@gmail.com; George.murphy@st-hugh's.ox.ac.uk;
   jagdeep.nanchahal@kennedy.ox.ac.uk
RI ; Glass, Graeme/I-7011-2019
OI Nanchahal, Jagdeep/0000-0002-9579-9411; 
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NR 45
TC 25
Z9 35
U1 0
U2 13
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2017
VL 70
IS 8
BP 1028
EP 1037
DI 10.1016/j.bjps.2017.05.027
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FB2YP
UT WOS:000406009900007
PM 28602266
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Yang, SL
   Zhu, LY
   Han, R
   Sun, LL
   Dou, JT
AF Yang, Shao Ling
   Zhu, Lv Yun
   Han, Rui
   Sun, Lei Lei
   Dou, Jing Tao
TI Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and
   Transforming Growth Factor-β1 Expression in Diabetic Foot Wounds
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE negative-pressure wound therapy; cellular fibronectin; transforming
   growth factor-beta 1; diabetic foot wounds
ID VACUUM-ASSISTED CLOSURE; GROWTH-FACTORS; ULCERS; PATHOGENESIS;
   MULTICENTER; ULCERATION; AMPUTATION; MORTALITY; FIBROSIS
AB Background: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can putatively facilitate wound healing, but the underlying mechanisms remain unclear. Cellular fibronectin (cFN) and transforming growth factor-beta 1 (TGF-beta 1) play an important role in wound healing. This prospective randomized controlled trial evaluated the effects of NPWT on the production of cFN and the expression of TGF-beta 1 in diabetic foot wounds of patients.
   Methods: From January 2012 to January 2015, 40 patients with diabetic foot wounds were randomly and equally apportioned to receive either NPWT or advanced moist wound therapy (control) for 7 days. Granulation tissue was harvested before and after treatment. Immunohistochemistry and Western blot were performed to evaluate protein levels of cFN and TGF-beta 1, and real-time polymerase chain reaction (PCR) to measure corresponding mRNA expressions.
   Results: NPWT facilitated the expression of cFN and TGF-beta 1 in diabetic foot wounds. Immunohistochemical analysis revealed higher levels of cFN and TGF-beta 1 in the NPWT group than in the control group. Western blot and real-time PCR analysis further showed that protein and mRNA levels of cFN or TGF-beta 1 were higher in the NPWT group than that in the control group (P < .01, both).
   Conclusion: Our results showed that NPWT facilitated the production of cFN and the expression of TGF-beta 1 in granulation tissue in diabetic foot ulcers.
C1 [Yang, Shao Ling; Dou, Jing Tao] Chinese PLA Gen Hosp Hosp, Dept Endocrinol, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Yang, Shao Ling; Zhu, Lv Yun] Bethune Int Peace Hosp PLA, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China.
   [Han, Rui] Hebei Med Univ, Dept Neurol, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
   [Sun, Lei Lei] Armed Police Hosp Shandong, Dept Endocrinol, Jinan, Shandong, Peoples R China.
C3 Hebei Medical University
RP Dou, JT (通讯作者)，Chinese PLA Gen Hosp Hosp, Dept Endocrinol, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM doujingtao301@126.com
RI lvyun, zhu/Z-4736-2019
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NR 45
TC 23
Z9 35
U1 0
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD AUG
PY 2017
VL 38
IS 8
BP 893
EP 900
DI 10.1177/1071100717704940
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA FC3AK
UT WOS:000406710400010
PM 28459181
DA 2026-07-24
ER

PT J
AU Bukovcan, P
   Koller, J
   Hajská, M
   Záhorec, P
AF Bukovcan, Peter
   Koller, Jan
   Hajska, Marianna
   Zahorec, Peter
TI Clinical Experience With the Use of Negative Pressure Wound Therapy
   Combined With a Silver-impregnated Dressing in Mixed Wounds: A
   Retrospective Study of 50 Cases
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; silver-impregnated dressing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; OUTCOMES
AB Introduction. Although negative pressure wound therapy,(NPWT) has been used for more than 20 years, as far as the authors are aware, there is little research aimed at the evaluation of the combination of NPWT with a silver-impregnated dressing. Objective. The aim of this study was to examine the effect, efficacy, and safety of NPWT in conjunction with a silver-impregnated dressing. Materials and Methods. The authors used a retrospective study of 54 acute and chronic wounds treated in 50 patients over a 2-year period. Demographic data, wound characterizations, wound cultures before and after NPWT, the duration of NPWT and number of sponge changes-for each patient, the types of surgical procedures used for wound closure following NPWT, and the healing time and length of hospital stays were recorded. Results. In 26 wounds, deep structures (ie, bones and tendons) were exposed. The mean NPWT duration was 9.2 days. Mean healing time was 16 days. There was a statistically significant decrease in the pathogenic microbial strains after NPWT treatment combined with the silver-impregnated dressing (paired t test; P = 0.0038). The shift from complicated to, easier surgical wound-closure-procedures was observed. Discussion. According to all results obtained, described, and discussed, the authors consider the use of a nonadherent silver-impregnated. dressing in conjunction with: NPWT to be beneficial, and efficacious. No adverse events or reactions related to the silver-impregnated contact layer used during NPWT have been observed in the patients, which confirmed the safety of this method.
C1 [Bukovcan, Peter] Comenius Univ, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.
   [Bukovcan, Peter] Univ Hosp Ruzinov, Bratislava, Slovakia.
C3 Comenius University Bratislava
RP Bukovcan, P (通讯作者)，Comenius Univ, Dept Burns & Reconstruct Surg, Bratislava, Slovakia.; Bukovcan, P (通讯作者)，Univ Hosp Ruzinov, Bratislava, Slovakia.
EM bukovcanmed@gmail.com
OI Hajská, Marianna/0000-0002-0822-8929; Bukovcan,
   Peter/0000-0003-2877-932X
CR Baharestani MM, 2011, INT WOUND J, V8, P118, DOI 10.1111/j.1742-481X.2010.00756.x
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   Orgill DP, 2009, SURGERY, V146, P40, DOI 10.1016/j.surg.2009.02.002
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NR 20
TC 4
Z9 5
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2016
VL 28
IS 8
BP 255
EP 263
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DT7FB
UT WOS:000381651400004
PM 27560468
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Hansson, J
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hansson, Johan
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Microvascular Blood Flow Changes in the Small Intestinal Wall During
   Conventional Negative Pressure Wound Therapy and Negative Pressure Wound
   Therapy Using a Protective Disc Over the Intestines in Laparostomy
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; INTRAABDOMINAL
   HYPERTENSION; MANAGEMENT; FISTULAS
AB Objectives: Blood flow changes in the intestines during conventional negative pressure wound therapy (NPWT), and NPWT using a protective disc over the intestines in laparostomy.
   Background: Higher closure rates of the open abdomen have been reported with NPWT compared with other kinds of wound management. However, the method has been associated with increased development of fistulae. We have compared the changes in blood flow in the intestinal wall using conventional NPWT and NWPT with a protective disc between the intestines and the vacuum source.
   Methods: Midline incisions were made in 10 pigs and either conventional NPWT or NPWT with a disc over the intestines was applied. The microvascular blood flow was measured in the intestinal wall before and after the application of topical negative pressures of -50, -70, and -120 mmHg, using laser Doppler velocimetry.
   Results: The blood flow was significantly decreased (by 24%) after the application of conventional NPWT at -50 mmHg, compared with a slight decrease (2%) after the application of NWPT with a protective disc (P < 0.05). The blood flow was significantly decreased (by 54%) after the application of conventional NPWT at -120 mmHg, compared with a slight decrease (17%) after application of NPWT using a protective disc (P < 0.001).
   Conclusions: Inserting a disc between the intestines and the vacuum source in NPWT protects the intestines from ischemia. The decreased blood flow in the intestinal wall may induce ischemia, which could promote the development of intestinal fistulae.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Inst Surg Sci, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Uppsala University; Lund University
RP Lindstedt, S (通讯作者)，Univ Lund Hosp, Dept Cardiothorac Surg, Heart & Lung Ctr, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599;
   Ingemansson, Richard/0000-0001-7623-8953
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NR 28
TC 16
Z9 18
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JAN
PY 2012
VL 255
IS 1
BP 171
EP 175
DI 10.1097/SLA.0b013e31823c9ffa
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 869ZM
UT WOS:000298638900026
PM 22104565
DA 2026-07-24
ER

PT J
AU Raizman, R
AF Raizman, Rose
TI Fluorescence imaging guided dressing change frequency during negative
   pressure wound therapy: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bacterial fluorescence imaging; MolecuLight; negative pressure wound
   therapy; wound infection; wounds
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; BACTERIAL LOAD; MANAGEMENT;
   BIOBURDEN; DEVICE
AB Objective: Knowledge of wound bioburden can guide selection of therapies, for example, the use of negative pressure wound therapy (NPWT) devices with instillation in a heavily contaminated wound. Wound and periwound bacteria can be visualised in real-time using a novel, non-contact, handheld fluorescence imaging device that emits a safe violet light. This device was used to monitor bacterial burden in patients undergoing NPWT.
   Methods: Diverse wounds undergoing NPWT were imaged for bacterial (red or cyan) fluorescence as part of routine wound assessments.
   Results: We assessed 11 wounds undergoing NPWT. Bacterial fluorescence was detected under sealed, optically-transparent (routine) adhesive before dressing changes, on foam dressings, within the wound bed, and on periwound tissues. Bacterial visualisation in real-time helped to guide: (1) bioburden-based, personalised treatment regimens, (2) clinician selection of NPWT, with or without instillation of wound cleansers, and (3) the extent and location of wound cleaning during dressing changes. The ability to visualise bacteria before removal of dressings led to expedited dressing changes when heavy bioburden was detected and postponement of dressing changes for 24 hours when red fluorescence was not observed, avoiding unnecessary disturbance of the wound bed.
   Conclusion: Fluorescence imaging of bacteria prompted and helped guide the timing of dressing changes, the extent of wound cleaning, and selection of the appropriate and most cost-effective NPWT (standard versus instillation). These results highlight the capability of bacterial fluorescence imaging to provide invaluable real-time information on a wound's bioburden, contributing to clinician treatment decisions in cases where bacterial contamination could impede wound healing.
C1 [Raizman, Rose] Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.
   [Raizman, Rose] Scarborough Hlth Network, Dept Profess Practice, Scarborough, ON, Canada.
C3 University of Toronto
RP Raizman, R (通讯作者)，Univ Toronto, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.; Raizman, R (通讯作者)，Scarborough Hlth Network, Dept Profess Practice, Scarborough, ON, Canada.
EM rraizman@shn.ca
CR Blackshaw EL, 2018, J WOUND CARE, V27, P20, DOI 10.12968/jowc.2018.27.1.20
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   Timmers MS, 2005, ANN PLAS SURG, V55, P665, DOI 10.1097/01.sap.0000187182.90907.3d
   Wackenfors A, 2004, WOUND REPAIR REGEN, V12, P600, DOI 10.1111/j.1067-1927.2004.12602.x
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
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   Yang C, 2017, WOUNDS, V29, P240
   Yusuf E, 2013, WOUND REPAIR REGEN, V21, P677, DOI 10.1111/wrr.12088
NR 36
TC 19
Z9 19
U1 0
U2 8
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD SEP
PY 2019
VL 28
IS 9
SU S
BP S28
EP S37
DI 10.12968/jowc.2019.28.Sup9.S28
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IV4QI
UT WOS:000484257200004
PM 31509488
DA 2026-07-24
ER

PT J
AU Allen, D
   Robinson, T
   Schmidt, M
   Kieswetter, K
AF Allen, Diwi
   Robinson, Timothy
   Schmidt, Marisa
   Kieswetter, Kristine
TI Preclinical assessment of novel longer-duration wear negative pressure
   wound therapy dressing in a porcine model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
DE dressing peel force; epithelialization; granulation; negative pressure
   therapy; negative pressure wound therapy; NPT; NPWT; peel and place
   dressing; porcine model; wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; PAIN
AB While reticulated open cell foam (ROCF) is a well-established dressing for negative pressure wound therapy (NPWT), there is the known potential for granulation tissue ingrowth if left in place for longer than 72 h. This may cause wound bed disruption, bleeding, and pain upon dressing removal. In addition, any retained foam fragments may elicit an adverse tissue reaction. A novel, easy to use dressing designed to utilise the advantages of ROCF while addressing its challenges has recently been created. This 7 day study investigated the utility of a novel NPWT dressing under longer-duration wear circumstances while assessing the prevalence of tissue ingrowth and ease of dressing removal in full-thickness excisional wounds utilising a porcine model. Histopathology and morphometry evaluations indicated thicker granulation tissue with, depending on the parameters assessed, either comparable or better tissue quality for wounds treated with the novel dressing. Greater re-epithelialization levels were also evident compared with ROCF. Three-dimensional imaging analysis indicated faster wound fill with a corresponding decrease in wound area with the novel dressing. Furthermore, tissue ingrowth was limited to only ROCF-treated wounds, which was not unexpected in this longer-duration wear study. The force required to remove the novel dressing was considerably lower compared with ROCF, correlating to the tissue ingrowth results. Results of this study illustrate that the novel dressing provided more favourable wound healing results compared with traditional ROCF. In addition, reduction in the risk of tissue ingrowth and low dressing peel force may allow it to be used as a longer-wear dressing.
C1 [Allen, Diwi; Robinson, Timothy; Schmidt, Marisa; Kieswetter, Kristine] 3M Co, Med Solut Div, San Antonio, TX USA.
   [Allen, Diwi] 6203 Farinon Dr, San Antonio, TX 78249 USA.
C3 3M
RP Allen, D (通讯作者)，6203 Farinon Dr, San Antonio, TX 78249 USA.
EM dlallen@mmm.com
FU 3M
FX 3M
CR Agrawal V, 2015, J WOUND OSTOMY CONT, V42, P636, DOI 10.1097/WON.0000000000000189
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NR 19
TC 7
Z9 8
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2023
VL 31
IS 3
BP 349
EP 359
DI 10.1111/wrr.13084
EA MAY 2023
PG 11
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA K5JU9
UT WOS:000985654300001
PM 37074154
OA Bronze
DA 2026-07-24
ER

PT J
AU Myllykangas, HM
   Berg, LT
   Husso, A
   Halonen, J
AF Myllykangas, Heidi-Mari
   Berg, Leena T.
   Husso, Annastina
   Halonen, Jari
TI Negative pressure wound therapy in the treatment of deep sternal wound
   infections - a critical appraisal
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; mediastinitis; sternotomy; cardiac
   surgery; surgical flaps
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; MUSCLE FLAPS;
   MANAGEMENT; MORTALITY; SURGERY
AB Introduction. Negative pressure wound therapy (NPWT) has widely become the first-line option in the treatment of deep sternal wound infections. After several positive reports in comparison with conventional treatment, very recent studies comparing NPWT with early reconstruction have favored the latter. Our aim was to evaluate the effectiveness and safety of NPWT in comparison with early flap reconstruction. Materials and methods. We concluded a retrospective analysis of 125 patients with deep sternal wound infection treated in a single institution between the years 2006 and 2018. NPWT became the first-line treatment in our hospital in 2011. The study group consisted of 55 patients treated primarily with NPWT with or without subsequent flap reconstruction. The control group consisted of 60 patients treated with flap reconstruction without prior NPWT. Ten patients with an immediate re-fixation and direct wound closure were excluded. Results. There were no significant differences between the two groups concerning the type or urgency of the original open-heart surgery, age, gender, or co-morbidities. In the NPWT group there was significantly higher mortality (p = .002), longer stay in the intensive care unit (p = .028), and in the university hospital (p < .001) as well as higher number of operations (p < .001). However, there were somewhat more surgical complications in the control group as well as a higher number of distant flap reconstructions. Overall, five patients suffered from NPWT associated bleeding. Conclusion. Our results raise concerns about the wide use of NPWT as a first-line treatment of deep sternal wound infections. Further evaluative studies are warranted to confirm the results.
C1 [Myllykangas, Heidi-Mari] Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
   [Myllykangas, Heidi-Mari; Halonen, Jari] Univ Eastern Finland, Fac Med, Kuopio, Finland.
   [Berg, Leena T.] Kainuu Cent Hosp, Dept Plast Surg, Kajaani, Finland.
   [Husso, Annastina; Halonen, Jari] Kuopio Univ Hosp, Dept Cardiothorac Surg, Kuopio, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital
RP Myllykangas, HM (通讯作者)，Kuopio Univ Hosp, Dept Plast Surg, PL 100, Kuopio 70029, Finland.
EM Heidi.myllykangas@kuh.fi3
RI Halonen, Jari/K-9329-2018
OI Myllykangas, Heidi-Mari/0000-0003-0542-987X
FU Kuopio University Hospital Research Foundation
FX This study was supported by the Kuopio University Hospital Research
   Foundation.
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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   Barbera F, 2019, ANN PLAS SURG, V83, P195, DOI 10.1097/SAP.0000000000001799
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NR 31
TC 6
Z9 6
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1401-7431
EI 1651-2006
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD DEC 1
PY 2021
VL 55
IS 6
BP 327
EP 332
DI 10.1080/14017431.2021.1955963
EA JUL 2021
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XL3LP
UT WOS:000678353900001
PM 34304643
OA Bronze
DA 2026-07-24
ER

PT J
AU Kolek, M
   Duricová, J
   Brozmanová, H
   Sistík, P
   Jurica, J
   Kanková, K
   Motyka, O
   Kacírová, I
AF Kolek, Martin
   Duricova, Jana
   Brozmanova, Hana
   Sistik, Pavel
   Jurica, Jan
   Kankova, Klara
   Motyka, Oldrich
   Kacirova, Ivana
TI Vancomycin wound penetration in open-heart surgery patients receiving
   negative pressure wound therapy for deep sternal wound infection
SO ANNALS OF MEDICINE
LA English
DT Article
DE Deep sternal wound infection; exudate; negative pressure wound therapy;
   open-heart surgery; vancomycin; wound penetration
ID VACUUM-ASSISTED CLOSURE; CARDIAC-SURGERY; RISK-FACTORS; MEDIASTINITIS;
   MICROBIOLOGY; MANAGEMENT; IMPACT
AB Introduction
   It is hypothesized that systemically administered antibiotics penetrate wound sites more effectively during negative pressure wound therapy (NPWT). However, there is a lack of clinical data from patients who receive NPWT for deep sternal wound infection (DSWI) after open-heart surgery. Here, we evaluated vancomycin penetration into exudate in this patient group.
   Patients and methods
   For this prospective observational study, we enrolled 10 consecutive patients treated with NPWT for post-sternotomy DSWI. On the first sampling day, serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3 and 6 h after vancomycin administration. On the following three consecutive days, additional samples were collected, only before vancomycin administration.
   Results
   The ratio of average vancomycin concentration in wound exudate to in serum was higher for free (unbound) (1.51 +/- 0.53) than for total (bound + unbound) (0.91 +/- 0.29) concentration (p = 0.049). The percentage of free vancomycin was higher in wound exudate than serum (0.79 +/- 0.19 vs. 0.46 +/- 0.16; p = 0.04). Good vancomycin wound penetration was maintained on the following three days (vancomycin trough exudate-to-serum concentration ratio > 1). The total hospital stay was significantly longer in patients with DSWI (46 +/- 11.6 days) versus without DSWI (14 +/- 11.7 days) (p < 0.001). There was no in-hospital or 90-day mortality. Two patients experienced late DSWI recurrence. All-cause mortality was 4.8% during a median follow-up of 2.5 years.
   Conclusion
   Vancomycin effectively penetrates wound exudate in patients receiving NPWT for DSWI after open-heart surgery.
C1 [Kolek, Martin; Kankova, Klara] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Sistik, Pavel; Kacirova, Ivana] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Sistik, Pavel; Kacirova, Ivana] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Jurica, Jan] Masaryk Univ, Fac Med, Dept Pharmacol, Brno, Czech Republic.
   [Jurica, Jan] Masaryk Mem Canc Inst, Hosp Pharm, Brno, Czech Republic.
   [Motyka, Oldrich] VSB Tech Univ Ostrava, Fac Min & Geol, Dept Environm Engn, Ostrava, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; University Hospital
   Ostrava; University of Ostrava; Masaryk University; Masaryk Memorial
   Cancer Institute; Technical University of Ostrava
RP Kolek, M (通讯作者)，Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
EM martin.kolek@fno.cz
RI Kacirova, Ivana/I-4241-2016; Kolek, Martin/D-4115-2018; Motyka,
   Oldřich/AAF-1313-2020; Jurica, Jan/ABE-1694-2021; Brozmanova,
   ./G-9793-2019
OI Kacirova, Ivana/0000-0001-6618-754X; Kolek, Martin/0000-0002-0418-3006;
   Motyka, Oldřich/0000-0002-9644-0611; Jurica, Jan/0000-0002-0257-6711; 
FU Ministry of health, czech Republic - conceptual development of research
   organization (FNOs/2021)
FX this work was supported by the Ministry of health, czech Republic -
   conceptual development of research organization (FNOs/2021).
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NR 29
TC 1
Z9 2
U1 2
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2025
VL 57
IS 1
AR 2444544
DI 10.1080/07853890.2024.2444544
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q9Q8U
UT WOS:001387940600001
PM 39711425
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Schimmer, C
   Heinowski, C
   Hamouda, K
   Meybohm, P
   Madrahimov, N
   Färber, G
   Radakovic, D
AF Schimmer, Christoph
   Heinowski, Christina
   Hamouda, Khaled
   Meybohm, Patrick
   Madrahimov, Nodir
   Farber, Gloria
   Radakovic, Dejan
TI Variables Associated with Treatment Failure after Negative Pressure
   Wound Therapy in Poststernotomy Mediastinitis: A Case-Control Study
SO THORACIC AND CARDIOVASCULAR SURGEON
LA English
DT Article; Early Access
DE poststernotomy mediastinitis; negative pressure wound therapy; therapy
   failure
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; RECONSTRUCTION; FLAP
AB Background: This study investigated factors leading to treatment failure after negative pressure wound therapy (NPWT) in poststernotomy mediastinitis (PSM) patients. Methods: A single-center retrospective case-control study in 198 cardiac surgery patients with PSM and consecutive NPWT were retrospectively divided into two groups. Group I consisted of patients whose NPWT was successful (n = 117/198; 59.1%), while in Group II treatment, failure occurred (n = 81/198; 40.9%). The primary endpoint was treatment failure, defined as recurrence of wound infection requiring surgical treatment within 30 days after secondary wound closure. Results: Body mass index (BMI) >30 kg/m(2) (p = 0.04; odds ratio [OR] 1.07), diabetes mellitus (DM; p = 0.03; OR 1.94), and the number of sponge changes (p = 0.01; OR 1.57) showed an association with the occurrence of NPWT failure. During the study period, 10/198 (19.8%) patients died after secondary wound healing. In group I, 1/117 (0.9%) patient died versus group II with 9/81 (12.7%) patients. About 70% patients died from septic multiple organ failure. Conclusion: This study confirms that variables associated with treatment failure after NPWT in PSM are BMI >30 kg/m(2), diabetes mellitus (DM), and the "number of sponge changes," respectively. However, this does not mean that sponge changes increase the risk; rather, sponge changes are associated with more resistant germs, incomplete wound healing, and more aggressive infection. This implies that management should be in the hands of cardiac surgeons with extensive experience in septic surgery and at centers with expertise in order to minimize the duration of NPWT and thus the number of sponge changes.
C1 [Schimmer, Christoph; Hamouda, Khaled; Farber, Gloria; Radakovic, Dejan] Univ Hosp Wurzburg, Dept Cardiothorac & Thorac Vasc Surg, Wurzburg, Germany.
   [Heinowski, Christina; Meybohm, Patrick] Univ Hosp Wurzburg, Dept Anaesthesiol Intens Care Emergency & Pain Med, Wurzburg, Germany.
   [Madrahimov, Nodir] Julius Maximilians Univ Hosp Wuerzburg, Dept Thorac & Cardiovasc Surg, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Schimmer, C (通讯作者)，Univ Hosp Wurzburg, Dept Cardiothorac & Thorac Vasc Surg, Wurzburg, Germany.
EM schimmer_c@ukw.de
RI Meybohm, Patrick/KEE-5745-2024; Färber, Gloria/JAN-9598-2023
OI Meybohm, Patrick/0000-0002-2666-8696; Färber, Gloria/0000-0002-2153-2458
CR Bermúdez A, 2017, CIR CARDIOVASC, V24, P293, DOI 10.1016/j.circv.2016.11.054
   Cancelli G, 2022, J CARDIAC SURG, V37, P5263, DOI 10.1111/jocs.17189
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NR 17
TC 0
Z9 0
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0171-6425
EI 1439-1902
J9 THORAC CARDIOV SURG
JI Thorac. Cardiovasc. Surg.
PD 2025 NOV 13
PY 2025
DI 10.1055/a-2733-4361
EA NOV 2025
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 9UY7B
UT WOS:001615646600001
PM 41167592
DA 2026-07-24
ER

PT J
AU Stannard, JP
   Volgas, DA
   Stewart, R
   McGwin, G
   Alonso, JE
AF Stannard, James P.
   Volgas, David A.
   Stewart, Rena
   McGwin, Gerald, Jr.
   Alonso, Jorge E.
TI Negative Pressure Wound Therapy After Severe Open Fractures: A
   Prospective Randomized Study
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; osteomyelitis; VAC; severe open
   fractures; orthopaedic trauma
ID VACUUM-ASSISTED CLOSURE; OPEN TIBIAL FRACTURES; SOFT-TISSUE INJURIES;
   SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE; GRADE-IIIB; MANAGEMENT;
   INFECTION; SHAFT; OSTEOMYELITIS
AB Objectives: To evaluate the impact of negative pressure wound therapy (NPWT) after severe open fractures on deep infection.
   Design: Prospective randomized study.
   Setting: Academic level I trauma center.
   Patients/Participants: Fifty-nine patients with 63 severe high-energy open fractures were enrolled in this study, with data available on 58 patients with 62 open fractures.
   Intervention: Twenty-three patients with 25 fractures randomized to the control group and underwent initial irrigation and debridement followed by standard fine mesh gauze dressing, with repeat irrigation and debridement every 48-72 hours until wound closure. Thirty-five patients randomized to the NPWT group and had identical treatment except that NPWT was applied to the wounds between irrigation and debridement procedures until closure.
   Main Outcome Measurements: The presence or absence of deep wound infection. or osteomyelitis, wound dehiscence, and fracture union were primary outcome measures.
   Results and Conclusions: Control patients developed 2 acute infections (8%) and 5 delayed infections (20%), for a total of 7 deep infections (28%), whereas NPWT patients developed 0 acute infections, 2 delayed infections (5.4%), for a total of 2 deep infections (5.4%). There is a significant difference between the groups for total infections (P = 0.024). The relative risk ratio is 0.199 (95% confidence interval: 0.045-0.874), suggesting that patients treated with NPWT were only one-fifth as likely to have an infection compared with patients randomized to the control group. NPWT represents a promising new therapy for severe open fractures after high-energy trauma.
C1 [Stannard, James P.; McGwin, Gerald, Jr.] Univ Alabama, Div Orthopaed Surg, Dept Epidemiol, Birmingham, AL 35294 USA.
   [McGwin, Gerald, Jr.] Callahan Eye Fdn Hosp, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Stannard, JP (通讯作者)，Univ Alabama, Div Orthopaed Surg, Dept Epidemiol, 950 Fac Off Tower,510 S 20th St, Birmingham, AL 35294 USA.
EM james.stannard@ortho.uab.edu
OI Stannard, James P/0000-0001-8467-6494
FU Kinetics Concepts, Inc, San Antonio, TX
FX The research upon which this article is based was funded through a grant
   to J. R Stannard, MD, from Kinetics Concepts, Inc, San Antonio, TX.
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NR 42
TC 253
Z9 295
U1 3
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2009
VL 23
IS 8
BP 552
EP 557
DI 10.1097/BOT.0b013e3181a2e2b6
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 489ZF
UT WOS:000269465000002
PM 19704269
DA 2026-07-24
ER

PT J
AU Pontell, ME
   Saad, N
   Winters, BS
   Daniel, JN
   Saad, A
AF Pontell, Matthew E.
   Saad, Noah
   Winters, Brian S.
   Daniel, Joseph N.
   Saad, Adam
TI Reverse Sural Adipofascial Flaps with Acellular Dermal Matrix and
   Negative-Pressure Wound Therapy
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE acellular dermal matrix; lower-extremity wounds; negative-pressure wound
   therapy; reverse sural adipofascial flap; split-thickness skin graft;
   surgical flap
ID SOFT-TISSUE DEFECTS; FASCIOCUTANEOUS FLAP; ISLAND FLAP;
   FASCIOSUBCUTANEOUS FLAP; LEG; FOOT; ANKLE
AB The reverse sural adipofascial flap (RSAF) is used to reconstruct challenging wounds of the foot and ankle. It offers several advantages over the traditional reverse sural flap, including less venous congestion. To complete the reconstruction, split-thickness skin grafting (STSG) may be done immediately or in a delayed fashion; however, both scenarios result in suboptimal take rates and prolonged healing. An acellular dermal matrix (ADM; Integra; Ethicon Inc, Somerville, New Jersey) and negative-pressure wound therapy (NPWT) combined with RSAF followed by delayed STSG may decrease wound healing time.
   In this study, 8 patients underwent reconstruction of lower-extremity wounds with RSAF. Four patients underwent RSAF with immediate STSG, and 4 underwent RSAF with placement of the ADM and a vacuum-assisted closure device, with STSG at a later date. The 4 patients who underwent RSAF and immediate STSG had an average time to heal of 141.2 days, and 2 patients required reoperation. The 4 patients who underwent RSAF with an ADM and NPWT had an average time to heal of 104.5 days, and 1 patient required reoperation. Average time until STSG was 41.5 days. The latter group demonstrated a reduction in time to heal by an average of 36.7 days, or 25%. All 8 patients achieved successful wound closure.
   The RSAF is a durable option for complex lower-extremity reconstruction. Interim placement of ADM and NPWT may increase STSG take rates. Using this technique in conjunction with RSAF may decrease the overall healing time compared with RSAF with immediate STSG.
C1 [Pontell, Matthew E.; Saad, Adam] Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19104 USA.
   [Saad, Noah] Univ Maryland, Dept Surg, Baltimore, MD 21201 USA.
   [Winters, Brian S.] Rothman Inst, Egg Harbor Township, NJ USA.
   [Winters, Brian S.] Thomas Jefferson Univ, Orthoped Surg, Philadelphia, PA 19107 USA.
   [Daniel, Joseph N.] Rothman Inst Orthoped, Egg Harbor Township, NJ USA.
   [Daniel, Joseph N.] Rowan Univ, Sch Med, Stratford, NJ USA.
   [Saad, Adam] Inst Adv Reconstruct, Plast Surg Ctr, Egg Harbor Township, NJ USA.
C3 Drexel University; University System of Maryland; University of Maryland
   Baltimore; Rothman Institute; Thomas Jefferson University; Rothman
   Institute; Rowan University
RP Pontell, ME (通讯作者)，Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19104 USA.
OI Saad, Adam/0000-0003-3377-9877
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NR 18
TC 10
Z9 14
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD JAN
PY 2018
VL 31
IS 1
BP 612
EP 617
DI 10.1097/01.ASW.0000527290.81581.af
PG 6
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA GJ3IE
UT WOS:000435185000007
PM 29240590
DA 2026-07-24
ER

PT J
AU Yu, PX
   Yu, NZ
   Yang, XN
   Jin, XL
   Lu, HB
   Qi, ZL
AF Yu, Panxi
   Yu, Nanze
   Yang, Xiaonan
   Jin, Xiaolei
   Lu, Haibin
   Qi, Zuoliang
TI Clinical Efficacy and Safety of Negative-Pressure Wound Therapy on
   Flaps: A Systematic Review
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Review
DE negative-pressure wound therapy; flap; efficacy
ID VACUUM-ASSISTED CLOSURE; IMPLANTABLE DOPPLER PROBE; MUSCLE FLAP; VENOUS
   CONGESTION; PEDICLE FLAP; RECONSTRUCTION; MANAGEMENT; DEVICE; HEAD;
   COMPLICATIONS
AB Background Although flap transfer is a popular reconstructive procedure with a high success rate, it is associated with a high complication rate and low salvage rate. During the past decade, negative-pressure wound therapy (NPWT) has been increasingly applied to facilitate flap transfer and salvage flaps threatened by complications. It has achieved some success, but its efficacy and safety remain controversial because of the limited number of reports and lack of systematic reviews.
   Methods English-language articles describing the application of NPWT on flaps were screened using predetermined inclusion and exclusion criteria. The articles were summarized and divided into groups based on the purpose of NPWT application. The complication rate, success rate, and salvage rate were obtained. Results Among the 3,395 articles searched, 16 articles describing 137 flaps were eligible. NPWT was applied on 105 (76.4%) newly transferred flaps to facilitate flap attachment and on 32 (23.4%) complication-threatened flaps to relieve flap infection and venous congestion. In total, complications developed in six flaps, three of which were lost; thus, the complication rate was 5.7% (6/105) and the success rate was 97.1% (102/105). Only 1 of the 32 threatened flaps was not successfully salvaged; thus, the salvage rate was 96.9% (31/32).
   Conclusion NPWT may facilitate flap transfer with few side effects and help to rescue flaps threatened by infection and venous congestion with a high salvage rate. Further studies are needed to test the safety of NPWT application on flaps with arterial compromise.
C1 [Yu, Panxi; Yang, Xiaonan; Jin, Xiaolei; Lu, Haibin; Qi, Zuoliang] Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept 16, 33 Badachu Rd, Beijing 100144, Peoples R China.
   [Yu, Nanze] Chinese Acad Med Sci, Dept Plast Surg, Peking Union Med Coll Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Plastic Surgery Hospital - CAMS; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College Hospital
RP Qi, ZL (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll, Plast Surg Hosp, Dept 16, 33 Badachu Rd, Beijing 100144, Peoples R China.
EM qizuoliangls@163.com
RI ; Yang, Xiaonan/AAL-5154-2020
OI , Jin/0000-0001-9350-7916; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Uygur F, 2008, INT WOUND J, V5, P50, DOI 10.1111/j.1742-481X.2007.00362.x
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   Wettstein R, 2015, INT WOUND J, V12, P572, DOI 10.1111/iwj.12166
   Wu CC, 2015, ADV SKIN WOUND CARE, V28, P21, DOI 10.1097/01.ASW.0000459038.81701.fb
   Wu CC, 2014, MICROSURG, V34, P339, DOI 10.1002/micr.22212
   Yang YH, 2013, J PLAST RECONSTR AES, V66, pE209, DOI 10.1016/j.bjps.2013.03.006
   Yusuf E, 2013, WOUND REPAIR REGEN, V21, P677, DOI 10.1111/wrr.12088
NR 51
TC 20
Z9 28
U1 0
U2 16
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JUN
PY 2017
VL 33
IS 5
BP 358
EP 366
DI 10.1055/s-0037-1599076
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EV3TZ
UT WOS:000401683300008
PM 28235220
DA 2026-07-24
ER

PT J
AU Rezzadeh, KS
   Nojan, M
   Buck, A
   Li, A
   Vardanian, A
   Crisera, C
   Festekjian, J
   Jarrahy, R
AF Rezzadeh, Kameron S.
   Nojan, Miriam
   Buck, Anisa
   Li, Andrew
   Vardanian, Andrew
   Crisera, Christopher
   Festekjian, Jaco
   Jarrahy, Reza
TI The use of negative pressure wound therapy in severe open lower
   extremity fractures: identifying the association between length of
   therapy and surgical outcomes
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative pressure wound therapy; Perioperative; Reconstructive surgery
ID OPEN TIBIAL FRACTURES; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES;
   MANAGEMENT; RECONSTRUCTION; INFECTION; COVERAGE; TRAUMA
AB Background: Negative pressure wound therapy (NPWT) is a widely accepted method of temporary coverage for complex lower extremity wounds before definitive reconstruction. However, the precise role of NPWT in the perioperative management of patients with complicated lower extremity injuries remains unclear. In this study, we examine the effect of NPWT on flap complications and overall outcomes based on timing of soft-tissue reconstruction relative to initial injury and implementation of NPWT.
   Methods: We retrospectively reviewed the medical records of 32 consecutive patients presenting to a single institution receiving lower extremity reconstruction after Gustilo class IIIB or IIIC open tibial fractures over a 5-y period. Length of hospitalization, number of surgical procedures, flap failure, infection, and nonunion were parameters of interest in this study.
   Results: The incidence of complications in patients treated with NPWT was lower compared with patients who underwent wet-to-dry dressing changes, regardless of when surgery was performed. The highest rate of complications was observed in patients operated on >6 wk after injury and who received wet-to-dry dressing changes wound care. By comparison, those who underwent surgery within 1 wk of injury and who were bridged with NPWT had the lowest rate of complications.
   Conclusions: The use of NPWT therapy in the perioperative management of patients with open lower extremity fractures reduces complication rates associated with limb salvage surgery. Our results suggest that NPWT can be used as a temporizing measure to optimize patients before flap surgery, effectively lengthening the window of opportunity for definitive reconstruction. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Rezzadeh, Kameron S.; Nojan, Miriam; Buck, Anisa; Li, Andrew; Vardanian, Andrew; Crisera, Christopher; Festekjian, Jaco; Jarrahy, Reza] Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Dept Surg, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Jarrahy, R (通讯作者)，Univ Calif Los Angeles, David Geffen Sch Med, Div Plast & Reconstruct Surg, Dept Surg, 200 UCLA Med Plaza,Suite 465, Los Angeles, CA 90095 USA.
EM rjarrahy@mednet.ucla.edu
OI Vardanian, Andrew/0009-0004-9764-8029; Li, Anew/0000-0001-9933-7057
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NR 23
TC 23
Z9 30
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD DEC
PY 2015
VL 199
IS 2
BP 726
EP 731
DI 10.1016/j.jss.2015.06.004
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CV7DW
UT WOS:000364433600061
PM 26141870
DA 2026-07-24
ER

PT J
AU Ozer, AY
   Keskin, I
   Kelestemur, T
   Ayturk, N
   Ersavas, C
   Gunal, MY
AF Ozer, Aysel Y.
   Keskin, Ilknur
   Kelestemur, Taha
   Ayturk, Nilufer
   Ersavas, Cenk
   Gunal, Mehmet Y.
TI Efficacy of one-hour negative pressure wound therapy and magnetic field
   energy in wound healing
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE angiogenesis; magnetic field; negative pressure wound therapy; wound;
   wound care; wound dressing; wound healing
ID PULSED ELECTROMAGNETIC-FIELDS; VACUUM-ASSISTED CLOSURE; ANGIOGENESIS;
   OXYGEN; PROLIFERATION; VASOMOTION; EXPOSURE
AB Objective: Wound healing is an important aspect of health but needs further research to identify the effects and interactions of different treatment approaches on healing. The aims of this study were to investigate the effectiveness of one-hour negative pressure wound therapy (NPWT) and compare histological differences between one-hour NPWT and magnetic field energy (MFE) in rats on early-stage wound healing, wound size and angiogenesis. Method: Standardised wounds were created on Wistar rats that were allocated and divided into NPWT, MFE and control groups. Both treatments were applied for 1 hour/day for 10 days. Wound size, histological changes and wound area blood flow were assessed. Results: The wound size of all groups was similar on days 0, 2 and 10. The MFE group's wound size was smaller than the NPWT group on days 4, 6 and 8 (p < 0.05). Development of the granulation tissue in both the one-hour NPWT and MFE groups was greater than in the control group. Additionally, the inflammatory phase was shorter, and wounds entered the proliferative stage faster in the MFE group than both of the other groups. Conclusion: Treatment with MFE may be more effective in terms of early stage wound closure and angiogenesis. On the other hand, the NPWT group's wound area blood flow was significantly greater than the other two groups. MFE is superior to one-hour NPWT in terms of wound area and angiogenesis. Furthermore, it is worthwhile to note that one-hour NPWT increases bloodflow in the wound area, which stimulates healing.
C1 [Ozer, Aysel Y.] Marmara Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Istanbul, Turkiye.
   [Keskin, Ilknur] Istanbul Medipol Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkiye.
   [Kelestemur, Taha] Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr, Sch Med, Dept Physiol, Istanbul, Turkiye.
   [Ayturk, Nilufer] Canakkale Onsekiz Mart Univ, Sch Med, Dept Histol & Embryol, Canakkale, Turkiye.
   [Ersavas, Cenk] Istanbul Arel Univ, Sch Med, Dept Gen Surg, Istanbul, Turkiye.
   [Gunal, Mehmet Y.] Alanya Alaaddin Keykubat Univ, Sch Med, Dept Physiol, Antalya, Turkiye.
C3 Marmara University; Istanbul Medipol University; Istanbul Medipol
   University; Canakkale Onsekiz Mart University; Istanbul Arel University;
   Alanya Alaaddin Keykubat University
RP Ozer, AY (通讯作者)，Marmara Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Istanbul, Turkiye.
EM aysel.yildiz@marmara.edu.tr
RI Yıldız Ozer, Aysel/IXW-8134-2023; Gunal, Mehmet/AAT-9806-2021; keskin,
   ilknur/A-6521-2018
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NR 47
TC 0
Z9 0
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2024
VL 33
SU 1
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IR8X8
UT WOS:001168161000001
DA 2026-07-24
ER

PT J
AU Travis, TE
   Prindeze, NJ
   Shupp, JW
   Sava, JA
AF Travis, Taryn E.
   Prindeze, Nicholas J.
   Shupp, Jeffrey W.
   Sava, Jack A.
TI Intra-abdominal Pressure Monitoring During Negative Pressure Wound
   Therapy in the Open Abdomen
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Damage control laparotomy; Delayed abdominal closure; Negative pressure
   wound therapy; Open abdomen
ID ABDOMINAL COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE; FASCIAL
   CLOSURE; MANAGEMENT; HYPERTENSION; EXPERIENCE; SYSTEMS; WORD; WALL
AB Introduction: Negative pressure wound therapy (NPWT) is commonly used in open abdomen management, where there may be a simultaneous need for prevention of abdominal hypertension, tamponade of hemorrhage, and continuous fascial tension. The regional pressure dynamics of vacuum dressings are poorly understood.
   Methods: Three duroc swine underwent mid-line laparotomy and application of vacuum open abdomen dressing, with and without sponge packing. Twenty-five catheters were placed throughout the abdomen to capture and record pressures in each quadrant as the vacuum system was ranged between (-75 mmHg to -200 mmHg pressure). Vital signs and ventilator pressures were measured and recorded concomitantly.
   Results: No variations in ventilatory pressures or vital signs were observed with any setting. NPWT changed pressure in seven of seventy-five catheters (9%), five of which were related to abdominal packing. When data were grouped into abdominal wall, perihepatic, perisplenic, and deep abdominal regions, there was no significant change in abdominal pressure when packing was absent. With packing, only the abdominal wall region showed a pressure change, reaching a maximum of 20% of the set vacuum pressure.
   Conclusions: NPWT does only little to change the intraabdominal pressure, except in superficial locations in packed abdomens and does not appear to cause hemodynamic changes in a porcine open abdomen model. While NPWT may play an important role in fluid scavenging and fascial tensioning, there are likely to be few benefits or drawbacks specifically related to negative abdominal pressure in the deep abdomen. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Travis, Taryn E.; Prindeze, Nicholas J.; Shupp, Jeffrey W.] MedStar Hlth Res Inst, Firefighters Burn & Surg Res Lab, Washington, DC USA.
   [Travis, Taryn E.; Shupp, Jeffrey W.; Sava, Jack A.] MedStar Washington Hosp Ctr, Dept Surg, Washington, DC USA.
   [Travis, Taryn E.; Prindeze, Nicholas J.; Shupp, Jeffrey W.; Sava, Jack A.] Georgetown Univ, Dept Surg, Sch Med, Washington, DC USA.
C3 MedStar Health Research Institute; MedStar Washington Hospital Center;
   Georgetown University
RP Travis, TE (通讯作者)，MedStar Washington Hosp Ctr, Burn Ctr, 110 Irving St NW,Suite 3B55, Washington, DC 20010 USA.
EM taryn.e.travis@medstar.net
RI Travis, Taryn/AAK-8527-2021; Shupp, Jeffrey/AAW-3481-2021
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NR 26
TC 1
Z9 4
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD OCT
PY 2022
VL 278
BP 100
EP 110
DI 10.1016/j.jss.2022.04.019
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X2CD1
UT WOS:001096575300004
PM 35597024
DA 2026-07-24
ER

PT J
AU Jiménez, JO
   Barno, PA
   Rubio, DR
   Hernández, JDP
   Pérez, JCG
   Montes, IM
   Velasco, GR
   de Blas, ET
   Trill, JD
AF Ocana Jimenez, Juan
   Abadia Barno, Pedro
   Ramos Rubio, Diego
   Pina Hernandez, Juan Diego
   Garcia Perez, Juan Carlos
   Moreno Montes, Irene
   Rodriguez Velasco, Gloria
   Tobaruela de Blas, Estela
   Die Trill, Javier
TI Role of negative pressure wound therapy in the prevention of surgical
   site infection in colorectal surgery
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Surgical site infection; Negative pressure wound therapy; Mechanical
   bowel preparation; Colorectal surgery
ID VACUUM-ASSISTED CLOSURE; NOSOCOMIAL INFECTIONS; RISK-FACTORS;
   LAPAROTOMY; TRIAL; COMPLICATIONS; METAANALYSIS; DISEASE; SYSTEM; COSTS
AB Background: Surgical site infection (SSI) is one of the most frequent complications in colorectal surgery. It is diagnosed in 10 - 20% of colorectal procedures. Negative Pressure Wound Therapy (NPWT) has shown efficacy in the treatment of chronic and traumatic wounds, wound dehiscence, flaps and grafts. The main objective of this study is to assess NPWT in the prevention of SSI in colorectal surgery. Hospital stay reduction and SSI risk factors are secondary objectives.
   Methods: We present a prospective case-control study including 80 patients after a colorectal diagnosis and surgical procedure (elective and non-elective) in 2017. Forty patients were treated with prevention NPWT for one week. Forty patients were treated according to the standard postoperative surgical wound care protocol.
   Results: No significant differences were found in demographic variables, comorbidities, surgical approach, elective or non-elective surgery, mechanical bowel preparation and surgical procedure. Three patients has SSI in the NPWT group (8%) (95%CI 0 - 17.5). Ten patients presented SSI in the control group (25%) (95%CI 12.5 - 37.5) (p = 0.034); OR 0.7 (95%CI 0.006-0.964). Hospital stay in the NPWT group was 8 days versus 12 days in the non-NPWT group (p = 0.22). In the multivariate analysis, mechanical bowel preparation was found to be the only risk factor for SSI (p = 0.047; OR: 0.8, CI 0.45-0.93).
   Conclusions: NPWT is a useful SSI prevention treatment in colorectal surgery. (C) 2019 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Ocana Jimenez, Juan; Ramos Rubio, Diego] HU Ramon y Cajal, Cirugia Gen & Digest, Madrid, Spain.
   [Abadia Barno, Pedro; Pina Hernandez, Juan Diego; Garcia Perez, Juan Carlos; Moreno Montes, Irene; Rodriguez Velasco, Gloria; Tobaruela de Blas, Estela; Die Trill, Javier] HU Ramon y Cajal, Unidad Coloproctol, Cirugia Gen & Digest, Madrid, Spain.
RP Jiménez, JO (通讯作者)，HU Ramon y Cajal, Cirugia Gen & Digest, Madrid, Spain.
EM jocajim@gmail.com
RI Ramos, Diego/HSH-4501-2023; JUAN CARLOS, GARCIA PEREZ/U-8344-2017;
   /D-9245-2013
OI Ramos, Diego/0000-0003-0191-1968; die trill, javier/0000-0003-2116-9190;
   Abadía Barnó, Peo/0000-0003-4713-9870; JUAN CARLOS, GARCIA
   PEREZ/0000-0002-0326-7128; 
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NR 37
TC 9
Z9 12
U1 0
U2 8
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD MAY
PY 2019
VL 97
IS 5
BP 268
EP 274
DI 10.1016/j.ciresp.2019.03.001
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HW7EO
UT WOS:000466853000005
PM 30981468
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Karlakki, SL
   Hamad, AK
   Whittall, C
   Graham, NM
   Banerjee, RD
   Kuiper, JH
AF Karlakki, S. L.
   Hamad, A. K.
   Whittall, C.
   Graham, N. M.
   Banerjee, R. D.
   Kuiper, J. H.
TI Incisional negative pressure wound therapy dressings (iNPWTd) in routine
   primary hip and knee arthroplasties A RANDOMISED CONTROLLED TRIAL
SO BONE & JOINT RESEARCH
LA English
DT Article
DE NPWT; iNPWTd; Incisional wound; TKA; THA; Wound complications
ID VACUUM-ASSISTED CLOSURE; ORTHOPEDIC-SURGERY; SURGICAL-SITE;
   SUBATMOSPHERIC PRESSURE; MANAGEMENT; INFECTION; REPLACEMENT; PREVENTION;
   GUIDELINES; DRAINAGE
AB Objectives
   Wound complications are reported in up to 10% hip and knee arthroplasties and there is a proven association between wound complications and deep prosthetic infections. In this randomised controlled trial (RCT) we explore the potential benefits of a portable, single use, incisional negative pressure wound therapy dressing (iNPWTd) on wound exudate, length of stay (LOS), wound complications, dressing changes and cost-effectiveness following total hip and knee arthroplasties.
   Methods
   A total of 220 patients undergoing elective primary total hip and knee arthroplasties were recruited into in a non-blinded RCT. For the final analysis there were 102 patients in the study group and 107 in the control group.
   Results
   An improvement was seen in the study (iNPWTd) group compared to control in all areas. Peak post-surgical wound exudate was significantly reduced (p = 0.007). Overall LOS reduction (0.9 days, 95% confidence interval (CI) -0.2 to 2.5) was not significant (p = 0.07) but there was a significant reduction in patients with extreme values of LOS in the iNPWTd group (Moses test, p = 0.003). There was a significantly reduced number of dressing changes (mean difference 1.7, 95% CI 0.8 to 2.5, p = 0.002), and a trend to a significant four-fold reduction in reported post-operative surgical wound complications (8.4% control; 2.0% iNPWTd, p = 0.06).
   Conclusions
   Based on the results of this RCT incisional negative pressure wound therapy dressings have a beneficial role in patients undergoing primary hip and knee arthroplasty to achieve predictable length of stay, especially to eliminate excessive hospital stay, and minimise wound complications.
C1 [Karlakki, S. L.; Hamad, A. K.; Whittall, C.; Graham, N. M.; Banerjee, R. D.; Kuiper, J. H.] Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Oswestry SY10 7AG, Shrops, England.
   [Karlakki, S. L.; Hamad, A. K.; Whittall, C.; Graham, N. M.; Banerjee, R. D.; Kuiper, J. H.] Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
C3 Keele University; Keele University
RP Karlakki, SL (通讯作者)，Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Oswestry SY10 7AG, Shrops, England.; Karlakki, SL (通讯作者)，Robert Jones & Agnes Hunt Orthopaed Hosp, NHS FT, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
EM sudheer.karlakki@rjah.nhs.uk
RI Whittall, Catherine/AAW-8323-2021
OI Whittall, Catherine/0000-0003-4859-4293
FU Smith Nephew UK
FX The study was funded through a grant from Smith & Nephew UK, to cover
   the cost of NPWT dressings and data collection costs. C. Whitall
   declares she has received payment from Smith & Nephew for other work
   unrelated to this paper.
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NR 58
TC 96
Z9 104
U1 0
U2 11
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD AUG
PY 2016
VL 5
IS 8
BP 328
EP 337
DI 10.1302/2046-3758.58.BJR-2016-0022.R1
PG 10
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA DS7IM
UT WOS:000380956800002
PM 27496913
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mosser, P
   Kelm, J
   Anagnostakos, K
AF Mosser, Philipp
   Kelm, Jens
   Anagnostakos, Konstantinos
TI Negative Pressure Wound Therapy in the Management of Late Deep
   Infections After Open Reconstruction of Achilles Tendon Rupture
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE Achilles tendon; infection; split-thickness skin graft; vacuum-assisted
   closure
ID VACUUM-ASSISTED CLOSURE; COVERAGE; REPAIR; COMPLICATIONS; METAANALYSIS;
   STATE
AB Infection is a major complication after open reconstruction of Achilles tendon ruptures. We report on the use of vacuum-assisted closure (VAC) therapy in the treatment of late deep infections after open Achilles tendon reconstruction. Six patients (5 males [83.33%], 1 female [16.67%]; mean age, 52.8 [range 37 to 66] years) were been treated using an identical protocol. Surgical management consisted of debridement, lavage, and necrectomy of infected tendon parts. The VAC therapy was used for local wound preconditioning and infection management. A continuous negative pressure of 125 mm Hg was applied on each wound. For final wound closure, a split-thickness skin graft was performed. The skin graft healing process was also supported by VAC therapy during the first 5 days. The VAC dressings were changed a mean average of 3 (range 1 to 4) times until split-thickness skin grafting could be performed. The mean total duration of the VAC therapy was 13.6 +/- 5.9 days. The mean hospital stay was 31.2 +/- 15.9 days. No complications with regard to bleeding, seroma, or hematoma formation beneath the skin graft were observed. At a mean follow-up duration of 29.9 (range 4 to 65) months, no re-infection or infection persistence was observed. The VAC device seems to be a valuable tool in the treatment of infected tendons. The generalization of these conclusions should await the results of future studies with larger patient series. (C) 2015 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Mosser, Philipp; Anagnostakos, Konstantinos] Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
   [Kelm, Jens] Chirurg Orthopad Zentrum Illingen, Illingen, Germany.
C3 Universitatsklinikum des Saarlandes
RP Anagnostakos, K (通讯作者)，Univ Klinikum Saarlandes, Klin Orthopadie & Orthopad Chirurg, D-66421 Homburg, Germany.
EM k.anagnostakos@web.de
RI Anagnostakos, Konstantinos/MGC-8753-2025
CR Anagnostakos K, 2012, J WOUND CARE, V21, P333, DOI 10.12968/jowc.2012.21.7.333
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NR 22
TC 14
Z9 17
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2015
VL 54
IS 1
BP 2
EP 6
DI 10.1053/j.jfas.2014.09.040
PG 5
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA AW7CH
UT WOS:000346421600002
PM 25451209
DA 2026-07-24
ER

PT J
AU Burtt, KE
   Badash, I
   Leland, HA
   Gould, DJ
   Rounds, AD
   Patel, KM
   Carey, JN
AF Burtt, Karen E.
   Badash, Ido
   Leland, Hyuma A.
   Gould, Daniel J.
   Rounds, Alexis D.
   Patel, Ketan M.
   Carey, Joseph N.
TI The Efficacy of Negative Pressure Wound Therapy and Antibiotic Beads in
   Lower Extremity Salvage
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Negative-pressure wound therapy; Infection; Limb salvage; Microsurgery;
   Surgical flaps
ID VACUUM-ASSISTED CLOSURE; SEVERE OPEN FRACTURES; INFECTION-RATE;
   RISK-FACTORS; LOWER-LIMB; COMPLICATIONS; RECONSTRUCTION; MANAGEMENT;
   TRAUMA; TIME
AB Background: Antibiotic beads and negative pressure wound therapy (NPWT) represent two methods of wound management used during staged debridement in the post-trauma limb salvage pathway. The efficacy of NPWT and antibiotic beads in preventing infection remains unclear.
   Methods: This study is a retrospective review of patients with traumatic lower extremity open fractures who received NPWT and/or antibiotic beads before soft tissue reconstruction at an urban level 1 trauma center between August 2007 and December 2015. Patients with wound infections before application of NPWT and/or antibiotic beads were excluded.
   Results: In 73 lower extremities requiring soft tissue coverage, 46 received antibiotic beads and 48 received NPWT. Overall infection rate was 15.1%. Use of antibiotic beads was associated with a decreased risk of infection (6.4% versus 30.7%; P = 0.01). Use of NPWT was associated with an increased risk of one or more complications (45.7% versus 4.2%; P = 0.001). The development of infection was associated with a greater period of time between application of antibiotic beads (22 +/- 13 versus 12 +/- 6 d, P = 0.01) or NPWT (23 +/- 15 versus 10 +/- 11 d, P = 0.004) and soft tissue coverage. Overall limb salvage rate was 95.9%; secondary amputation was associated with development of infection (P = 0.001) but not with use of NPWT or antibiotic beads.
   Conclusions: Antibiotic beads may prevent infections in patients awaiting soft tissue coverage of wounds. NPWT may contribute to a greater rate of complication. Limb salvage was successful in most cases regardless of method of wound management. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Burtt, Karen E.] Mt Sinai Med Ctr, Dept Gen Surg, 4300 Alton Rd, Miami Beach, FL 33140 USA.
   [Badash, Ido; Gould, Daniel J.; Rounds, Alexis D.; Patel, Ketan M.; Carey, Joseph N.] USC, Keck Sch Med, Div Plast & Reconstruct Surg, Los Angeles, CA USA.
   [Leland, Hyuma A.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Mount Sinai Medical Center; University of Southern California;
   University of Southern California Keck Hospital; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center
RP Burtt, KE (通讯作者)，Mt Sinai Med Ctr, Dept Gen Surg, 4300 Alton Rd, Miami Beach, FL 33140 USA.
EM burtt@usc.edu
RI Badash, Ido/HLG-7360-2023
OI Badash, Ido/0000-0002-8512-1738; Rounds, Alexis/0000-0002-3927-3191
CR [Anonymous], INT SCH RES NOT
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NR 28
TC 7
Z9 11
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2020
VL 247
BP 499
EP 507
DI 10.1016/j.jss.2019.09.055
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KM1VD
UT WOS:000513908200065
PM 31690532
DA 2026-07-24
ER

PT J
AU Yang, C
   Goss, SG
   Alcantara, S
   Schultz, G
   Lantis, JC
AF Yang, Chun
   Goss, Selena G.
   Alcantara, Sean
   Schultz, Greg
   Lantis, John C., II
TI Effect of Negative Pressure Wound Therapy With Instillation on Bioburden
   in Chronically Infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE biofilm; planktonic bacteria; negative pressure wound therapy with
   installation; debridement; wound bed preparation
ID VACUUM-ASSISTED CLOSURE; CLINICAL-EXPERIENCE; BIOFILMS; RESISTANCE;
   IRRIGATION; MECHANISMS; BACTERIA
AB Introduction. Standard negative pressure wound therapy (NPWT) has been shown to help close wounds despite increasing planktonic bioburden. Both planktonic and biofilm critical colonization are associated with delayed wound healing; therefore, reducing microbial colonization is thought to aid wound healing. The use of NPWT with topical antimicrobial irrigation solution has previously shown reduction in quantitative planktonic bioburden when combined with sharp debridement in chronic wounds. Objective. The goal of this study was to evaluate the effectiveness of NPWT with instillation (NPWTi) on biofilm of chronic wounds. Materials and Methods. A prospective, randomized trial was conducted. Following sharp debridement, 20 patients with chronic wounds were randomized to 1 week of either NPWTi with 0.125% sodium hypochlorite solution (n = 10) or NPWT without instillation (n = 10). Serial wound biopsy was performed predebridement, postdebridement, and after 1 week of study therapy to test for quantitative nonplanktonic or biofilm-protected bacteria. Results. As expected, there was no difference in change in wound size between the 2 groups at 1 week. The NPWTi group had a mean reduction in quantitative biofilm-protected bacteria of 48%, while the NPWT without instillation group had a mean increase of 14% (P < .05). Discussion. Consistent with previous studies, this trial demonstrates that NPWTi with dilute sodium hypochlorite solution is effective at reducing non planktonic bioburden of chronically, critically colonized wounds. Conclusions. Therefore, based on this and previously published work, this therapy provides both planktonic and nonplanktonic bioburden reduction as well as NPWT benefits and may be a tool for the preparation of infected wound beds prior to definitive closure.
C1 [Yang, Chun; Goss, Selena G.; Alcantara, Sean; Lantis, John C., II] Mt Sinai St Lukes West Hosp, New York, NY USA.
   [Schultz, Greg] Univ Florida, Gainesville, FL USA.
C3 Mount Sinai Morningside; Mount Sinai West; State University System of
   Florida; University of Florida
RP Lantis, JC (通讯作者)，1090 Amsterdam Ave,Suite 12, New York, NY 10025 USA.
EM JLantis@chpnet.org
FU Acelity; Smith Nephew; Kerecis; Intregra
FX Dr. Schultz is a paid consultant for Acelity and Smith & Nephew. Dr.
   Lantis is a paid consultant for Acelity, Smith & Nephew, Kerecis, and
   Intregra.
CR [Anonymous], 2006, ADV SKIN WOUND CARE
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NR 29
TC 59
Z9 67
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2017
VL 29
IS 8
BP 240
EP 246
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA FF2BK
UT WOS:000408702700005
PM 28570250
DA 2026-07-24
ER

PT J
AU Lynam, S
   Mark, KS
   Temkin, SM
AF Lynam, Sarah
   Mark, Katrina S.
   Temkin, Sarah Madhu
TI Primary Placement of Incisional Negative Pressure Wound Therapy at Time
   of Laparotomy for Gynecologic Malignancies
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Closed incision; Negative pressure wound therapy; Surgical site
   infections; Laparotomy; Quality improvement
ID SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED CLOSURE; OBESE WOMEN; SURGERY;
   COMPLICATIONS; PREDICTORS; IMPACT; COSTS
AB Objective Wound complications are an important cause of postoperative morbidity amongst patient with gynecologic malignancies. We evaluated whether the placement of prophylactic negative pressure wound therapy (NPWT) at the time of laparotomy for gynecologic cancer surgery reduces wound complication rates.
   Methods A retrospective analysis of patients undergoing laparotomy with primary wound closure performed by a gynecologic oncologist at a single academic institution over a 5-year study period was performed. Patients who had placement of prophylactic NPWT dressing were compared with patients with a standard closure. Postoperative outcomes were examined.
   Results A total of 230 patients were identified: 208 women received standard wound care, 22 received NPWT. Groups were similar in age, prevalence of diabetes, tobacco use, and number of previous abdominal procedures. Intraoperative factors including length of procedure and transfusion requirements were similar. Body mass index for patients receiving standard treatment was 30.67 compared with 41.29 for NPWT group (P < 0.001). Incidence of all wound complications was 19.7% for those receiving standard treatment versus 27.3% for NPWT group (P = 0.40). Length of hospital stay was similar between the 2 groups (5.25 vs 6.22 days, P = 0.20). There were 3 hospital readmissions for wound complicationsnone occurred in women with a prophylactic NPWT dressing.
   Conclusions Despite significantly higher obesity rates, patients with prophylactic NPWT dressing placement had similar rates of wound complications. Our findings suggest a potential therapeutic benefit in the use of prophylactic NPWT for the reduction of wound complications in this high-risk gynecologic oncology patient population.
C1 [Lynam, Sarah; Mark, Katrina S.; Temkin, Sarah Madhu] Univ Maryland, Sch Med, Dept Obstet Gynecol & Reprod Sci, Baltimore, MD 21201 USA.
   [Temkin, Sarah Madhu] Johns Hopkins Univ Hosp, Dept Gynecol & Obstet, Baltimore, MD 21287 USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Medicine
RP Temkin, SM (通讯作者)，600 North Wolfe St,Phipps 281, Baltimore, MD 21287 USA.
EM stemkin1@jhmi.edu
OI Lynam, Sarah/0000-0003-1474-6527; Mark, Katrina/0000-0001-5127-2936
CR [Anonymous], 2016, Cancer facts and figures 2016
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NR 26
TC 18
Z9 19
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1048-891X
EI 1525-1438
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD OCT
PY 2016
VL 26
IS 8
BP 1525
EP 1529
DI 10.1097/IGC.0000000000000792
PG 5
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA DZ2IL
UT WOS:000385665400026
PM 27488215
DA 2026-07-24
ER

PT J
AU Bi, HD
   Fang, S
   Jiang, D
   Xing, X
   Zhu, J
   Wang, XY
   Dai, HY
   Zhong, XY
   Li, JH
AF Bi, Hongda
   Fang, Shuo
   Jiang, Dong
   Xing, Xin
   Zhu, Ji
   Wang, Xiaoyun
   Dai, Haiying
   Zhong, Xueying
   Li, Junhui
TI Ultrasound-guided scraping of fibrous capsule plus bilayered negative
   pressure wound therapy for treatment of refractory postmastectomy seroma
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Seroma; Negative pressure wound therapy; Wound healing; Drainage
ID VACUUM-ASSISTED CLOSURE; BREAST-CANCER SURGERY; AXILLARY DISSECTION;
   FIBRIN SEALANT; PREVENTION; COMPLICATIONS; SUCTION; RECONSTRUCTION;
   MANAGEMENT; MASTECTOMY
AB Introduction: Seroma is a frequent complication of breast cancer surgery. Treatment of prolonged or refractory seroma remains a clinical challenge. This study aimed to evaluate the efficacy of a novel approach for refractory seroma treatment; the method combines minimally invasive scraping for fibrous capsule removal and self-designed bilayered negative pressure wound therapy (b-NPWT) to achieve favorable wound healing.
   Methods: Twenty-four patients with refractory seroma received ultrasound-guided scraping of fibrous capsule around the refractory seroma, and then a bilayered NPWT system simultaneously allowing for fluid drainage and dynamic topical pressure was manually implemented immediately. The time of NPWT application and wound healing was recorded, and pathological examination was conducted for the removed fibrous tissues.
   Results: Removal of the fibrous capsule was securely achieved by minimally invasive scraping through a 1.5-cm incision guided with ultrasound scanning. All refractory seromas in the 24 patients healed uneventfully after an average application of NPWT for 7.2 +/- 3.3 days without recurrence during the 3-12 months of follow-up. Biopsy of the removed fibrous tissue demonstrated that single-layered endothelial cells stained with CD31, D2-40, and Ki-67 existed both on the surface of and inside the fibrous tissue.
   Conclusions: The combination of fibrous capsule removal by ultrasound-guided scraping with successive bilayered NPWT therapy is effective and minimally invasive for promoting wound healing of refractory postmastectomy seroma. (C) 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Bi, Hongda; Fang, Shuo; Xing, Xin; Zhu, Ji; Wang, Xiaoyun; Dai, Haiying; Zhong, Xueying; Li, Junhui] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai 200433, Peoples R China.
   [Jiang, Dong] Second Mil Med Univ, Changhai Hosp, Dept Ultrasound, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Xing, X (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM xingxin57@163.com; Lissot@163.com
CR Abe, 1998, Breast Cancer, V5, P67
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NR 31
TC 4
Z9 6
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2015
VL 68
IS 3
BP 403
EP 409
DI 10.1016/j.bjps.2014.11.007
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB9VL
UT WOS:000349981500024
PM 25547936
DA 2026-07-24
ER

PT J
AU Paradiso, FV
   Silvaroli, S
   Nanni, L
AF Paradiso, Filomena Valentina
   Silvaroli, Sara
   Nanni, Lorenzo
TI Negative pressure wound therapy (NPWT) in the open abdomen in a preterm
   newborn with necrotizing enterocolitis: case report
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Open abdomen; Necrotizing enterocolitis; Negative pressure wound therapy
   (NPWT); Kerlix Antimicrobial Dressing (AMD)
ID VACUUM-ASSISTED CLOSURE
AB Background Necrotizing enterocolitis (NEC) totalis is a devastating intestinal disease that affects similar to 5% of preterm neonates; its appropriate surgical management is still controversial. Although the temporary open abdomen associated with negative pressure wound therapy (NPWT) has become an increasingly used therapeutic option, its use is still relatively limited in premature babies with NEC.
   Case report On the 6th day of life a male preterm neonate born at 32 + 3 weeks of gestational age (1570 g) developed bowel perforation. He underwent a bed-side laparotomy and a NEC totalis was found with three intestinal perforations (one jejunal and two contiguous ileal perforations). In order to re-esplore the baby, an open abdomen NPWT was applied (Suprasorb CNP P3-Lohmann-Rauscher), with an intrabdominal drainage film, setting the pressure at -20 mmHg. After 72 h a second surgery was performed. The entire bowel showed a good trophism; no new perforations were found. The two ileal perforations were closed with running sutures and a jejunostomy was performed. The postoperative course was uneventful and the oral feeding started on the fifth postoperative day. Two months later a barium enema through the mucous fistula showed a normal intestinal progression of the contrast medium, and the jejunostomy was closed.
   Conclusion The temporary open abdomen associated with NPWT is a valuable resource in critical premature neonates; it allows the creation of a "artificial third space" which is crucial in lowering bowel edema and intrabdominal pressure. Moreover, the use of an intrabdominal film may represent a new perspective whose effectiveness needs further studies.
C1 [Paradiso, Filomena Valentina; Silvaroli, Sara; Nanni, Lorenzo] Fdn Policlin Univ Agostino Gemelli IRCCS, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Paradiso, FV (通讯作者)，Fdn Policlin Univ Agostino Gemelli IRCCS, Div Pediat Surg, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
EM filomenavalentina.paradiso@policlinicogemelli.it;
   sara.silvaroli@policlinicogemelli.it;
   lorenzo.nanni@policlinicogemelli.it
RI ; Paradiso, Filomena/OGN-6517-2025
OI Paradiso, Filomena Valentina/0000-0001-6993-3886; 
CR Fenton SJ, 2007, J PEDIATR SURG, V42, P957, DOI 10.1016/j.jpedsurg.2007.01.029
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   Principles of Best Practice, 2009, VACUUM ASSISTED CLOS
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   Zani A, 2015, NECROTIZING ENTEROCO
NR 15
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1720-8424
EI 1824-7288
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD MAR 5
PY 2026
VL 52
IS 1
AR 57
DI 10.1186/s13052-026-02220-x
EA MAR 2026
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GM2DE
UT WOS:001739717400001
PM 41787431
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Abe, Y
   Ishida, S
   Mineda, K
   Yamashita, Y
   Nagasaka, S
   Yamasaki, H
   Hashimoto, I
AF Abe, Yoshiro
   Ishida, Soushi
   Mineda, Kazuhide
   Yamashita, Yutaro
   Nagasaka, Shinji
   Yamasaki, Hiroyuki
   Hashimoto, Ichiro
TI One-Stage Perifascial Areolar Tissue and Skin Grafting Combined with
   Negative Pressure Wound Therapy for a Refractory Wound with an Exposed
   Elbow Joint and Extensive Skin Defect
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Elbow joint exposure; Perifascial areolar tissue; Negative pressure
   wound therapy; One-stage PAT and skin grafting combined with NPWT; Soft
   tissue sarcoma
ID VACUUM-ASSISTED CLOSURE; MICROCIRCULATION; BONE
AB Joint exposure with an extensive skin defect following soft tissue tumor resection might cause a refractory ulcer. Although a vascularized tissue transplant is ideal for ulcer treatment, it is a highly invasive procedure and usually unsuitable for older patients with general prostration. One-stage perifascial areolar tissue (PAT) and skin grafting combined with negative pressure wound therapy (NPWT) is less invasive and effective procedure for refractory wounds with exposed bones and tendons. This is the first case where this procedure was used to treat a wound that involved an exposed elbow joint with an extensive skin defect. An 80-year-old woman underwent wide excision to remove a leiomyosarcoma on the olecranon with reconstruction using an ipsilateral pedicled latissimus dorsi musculocutaneous flap. The distal three-quarter of the flap was necrosed owing to insufficient blood supply. Furthermore, an articular capsule deficit of 1.5 x 1.0 cm(2) was found during necrotomy. The PAT was harvested from the lower abdomen as a non-vascularized tissue, and the articular capsule deficit was covered by overlapping on the granulation tissue around the deficit. Simultaneous split-thickness skin grafting combined with NPWT was applied on the PAT and residual skin defect. Wound healing was achieved in 4 weeks postoperatively without synovial fluid leakage. Elbow joint motion ranging from 0 to 120 degrees was maintained 18 months postoperatively. This procedure helped achieve better wound healing and sufficient functional outcome. Furthermore, this can help decrease patients' burden by preventing invasive resections associated with severe functional impairments or long-term rehabilitation requirements.
C1 [Abe, Yoshiro; Ishida, Soushi; Mineda, Kazuhide; Yamashita, Yutaro; Nagasaka, Shinji; Yamasaki, Hiroyuki; Hashimoto, Ichiro] Tokushima Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
C3 Tokushima University
RP Abe, Y (通讯作者)，Tokushima Univ, Dept Plast & Reconstruct Surg, Grad Sch Biomed Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM y.abe@tokushima-u.ac.jp
RI ; /AFK-5986-2022
OI Abe, Yoshiro/0000-0002-7445-2857; yamashita, yutaro/0000-0002-8044-0721;
   
CR Abe Y, 2018, J MED INVESTIG, V65, P96, DOI 10.2152/jmi.65.96
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   Koizumi T, 2010, PLAST RECONSTR SURG, V126, p182E, DOI 10.1097/PRS.0b013e3181ea91e3
   Kouraba S., 2003, ANZ J SURG, V73, pA260, DOI DOI 10.1046/J.1445-2197.2003.26311234.X
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nakajima H, 2004, SCAND J PLAST RECONS, V38, P261, DOI 10.1080/02844310410029543
   Nao EEM, 2011, EUR ANN OTORHINOLARY, V128, P47, DOI 10.1016/j.anorl.2010.12.001
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Soejima K, 2006, BURNS, V32, P312, DOI 10.1016/j.burns.2005.10.013
NR 26
TC 0
Z9 1
U1 0
U2 1
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD OCT
PY 2022
VL 84
IS 5
BP 1067
EP 1073
DI 10.1007/s12262-021-03188-0
EA NOV 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5N0OT
UT WOS:000723525200002
DA 2026-07-24
ER

PT J
AU O'Malley, P
   McDonnell, C
AF O'Malley, Paula
   McDonnell, Ciaran
TI Negative pressure wound therapy-two novel approaches to healing dehisced
   vascular bypass wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE bypass graft; diabetes; dressing; infection; negative pressure wound
   therapy.; surgical wound healing by secondary intention; vascular
   wounds; wound
ID VACUUM-ASSISTED CLOSURE; INFECTIONS
AB The use of negative pressure wound therapy (NPWT) in surgical wound healing by secondary intention is well known. Its use in healing dehisced vascular bypass wounds is contraindicated by manufacturers due to exposed vasculature and risk of bleeding. There is an increasing body of knowledge to support the use of NPWT in vascular wounds in order to prevent graft excision and the need for flap closure. This paper reports the use of two different approaches using NPWT to heal dehisced, infected vascular groin bypass wounds in two patients. Both patients had lower limb bypass using Dacron (Vascutek Ltd., UK) grafts and subsequently became infected, dehisced and required debridement. Following debridement, graft was visible in the wound bed and NPWT was applied to facilitate healing. Case one had polyurethane (black) foam and a layer of petroleum-impregnated cellulose acetate mesh to prevent adherence to the graft. Case two had polyvinyl alcohol (white) (PVA) foam applied to the wound. The PVA foam was used in Case two due to pain at dressing changes. Negative pressure was initially -25mmHg but increased gradually to -125mmHg and -150mmHg, respectively, the therapeutic pressure for the respective foams. Dressings were changed every 48-72 hours and infection treated with antibiotics as appropriate. After eight days and 28 days of NPWT, respectively, graft was no longer visible. No significant bleeding was noted. These two case studies would suggest that, with precautions taken to protect the vasculature, the use of NPWT in healing dehisced vascular groin wounds is an appropriate treatment.
C1 [O'Malley, Paula; McDonnell, Ciaran] Mater Private Hosp, Dublin, Ireland.
C3 Mater Private Hospital
RP O'Malley, P (通讯作者)，Mater Private Hosp, Dublin, Ireland.
EM paula.omalley@materprivate.ie
CR Apelqvist Jan, 2017, J Wound Care, V26, pS1, DOI [10.12968/jowc.2017.26.sup3.s1, 10.12968/jowc.2017.26.Sup3.S1]
   Dosluoglu HH, 2005, J VASC SURG, V42, P989, DOI 10.1016/j.jvs.2005.07.006
   Dowsett C., 2012, WOUNDS UK, V8, P48
   Dumville JC, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011278.pub2
   Henderson V., 2010, WOUNDS INT, V1, P1
   KCI, 2015, VAC THER CLIN GUID R
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Lakhiani C, 2019, J VASC SURG CASES IN, V5, P435, DOI 10.1016/j.jvscit.2019.04.008
   McNulty AK, 2007, WOUND REPAIR REGEN, V15, P838, DOI 10.1111/j.1524-475X.2007.00287.x
   Monsen C, 2014, J VASC SURG, V59, P145, DOI 10.1016/j.jvs.2013.06.073
   Peart J., 2019, WOUNDS UK, V15, P20
   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   Tan KW, 2017, ANN VASC DIS, V10, P386, DOI 10.3400/avd.oa.17-00052
   Thorbjornsen K, 2016, EUR J VASC ENDOVASC, V51, P724, DOI 10.1016/j.ejvs.2016.01.011
   Williams IM, 2003, EUR J VASC ENDOVASC, V25, P390, DOI 10.1053/ejvs.2002.1890
NR 17
TC 1
Z9 1
U1 0
U2 9
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JUN
PY 2021
VL 30
IS 6
BP 449
EP 453
DI 10.12968/jowc.2021.30.6.449
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ST0ZV
UT WOS:000662180700006
PM 34121434
DA 2026-07-24
ER

PT J
AU Bayci, A
   Akay, B
AF Bayci, Andrew
   Akay, Begum
TI Advanced Techniques in the Use of Negative Pressure Wound Therapy for
   Closure of Complex Neonatal Abdominal Wounds
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Complex wound care; Negative pressure wound therapy; Neonatal medicine;
   Pediatric surgery
ID VACUUM-ASSISTED CLOSURE
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been described for closure of complex neonatal abdominal wounds, but advanced techniques for stoma or fistula control, skin protection, and the use of high pressure therapy not as well established.
   CASES: We identified neonatal patients at our institution who received NPWT for a complex abdominal wound, defined as a wound associated with a stoma or fistula with partial or complete dehiscence of the abdominal fascia or skin. We then reviewed techniques for decreasing wound contamination and protecting the newborn's skin. One patient had an especially complex wound; she was born at similar to 23 weeks' gestational age (birth weight 580 g). She developed necrotizing enterocolitis and strictures, requiring multiple surgeries to relieve obstruction, ultimately resulting in an end ileostomy with mucous fistula. She suffered from wound dehiscence and retraction of her surgically created stoma, resulting in a complex abdominal wound with significant damage to the surrounding skin. We used advanced NPWT techniques to heal her wound, including topical skin protectants, placement of an adhesive dressing over the skin prior to placement of negative pressure dressing, placement of a negative pressure sponge directly on the wound bed and stoma, diversion of enteric contents away from the wound using a Malecot catheter, and an increase in the negative pressure applied.
   CONCLUSION: Complex neonatal abdominal wounds can be treated effectively using NPWT. The techniques we describe divert enteric contents away from the wound bed while maintaining negative pressure and protecting the surrounding skin. In addition, we used negative pressure up to -125 mm Hg and found it was well tolerated by our patients.
C1 [Bayci, Andrew] Beaumont Hlth, Dept Gen Surg, Royal Oak, MI USA.
   [Akay, Begum] Beaumont Childrens, Dept Pediat Surg, Royal Oak, MI USA.
C3 Beaumont Health; Beaumont Health
RP Bayci, A (通讯作者)，5021 Prentis Dr, Troy, MI 48085 USA.
EM Andrew.Bayci@gmail.com
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argo R, 2014, J WOUND OSTOMY CONT, V41, P222, DOI 10.1097/WON.0000000000000033
   Boyar V, 2018, J WOUND OSTOMY CONT, V45, P117, DOI 10.1097/WON.0000000000000407
   Lopez G, 2008, J PEDIATR SURG, V43, P2202, DOI 10.1016/j.jpedsurg.2008.08.067
   McGarrah B, 2015, J WOUND OSTOMY CONT, V42, P409, DOI 10.1097/WON.0000000000000139
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Stoffan AP, 2012, J PEDIATR SURG, V47, P1555, DOI 10.1016/j.jpedsurg.2012.01.014
NR 8
TC 5
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD SEP-OCT
PY 2018
VL 45
IS 5
BP 468
EP 471
DI 10.1097/WON.0000000000000471
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HB2SD
UT WOS:000450891800013
PM 30188395
DA 2026-07-24
ER

PT J
AU Guomundsdóttir, I
   Steingrimsson, S
   Guobjartsson, T
AF Guomundsdottir, Ingibjorg
   Steingrimsson, Steinn
   Guobjartsson, Tomas
TI Negative pressure wound therapy in Iceland - indication and outcome
SO LAEKNABLADID
LA Icelandic
DT Article
DE Negative pressure wound therapy (NPWT); wound infectons; indications;
   outcome; healing rate
ID VACUUM-ASSISTED CLOSURE; TRIAL; MULTICENTER; ULCERS
AB Introduction: Negative pressure wound therapy (NPWT) is a recent therapeutic option in wound healing, where a vacuum source is used to create sub-atmospheric pressure in the wound bed with airtight dressings. The aims were to study the indications for the use of NPWT in a whole country and evaluate the outcome of treatment.
   Material and methods: This was a retrospective study that included all patients that were treated with NPWT in Iceland between January and December 2008. Information on indication, duration and outcome of treatment was collected from patient charts. Factors that are known to affect wound healing, such as diabetes, smoking and age, were also registered.
   Results: During the 12 month study period a total of 65 NPWT-treatments were given to 56 patients; 35 (63%) males and 21 (37%) females, with an average age of 62 yrs (range; 8 - 93). The indications for treatment were: wound infection (40%), promotion of wound healing (42%) and keeping cavities open (19%). The lower limbs (26%) and chest area (25%) were the most common sites for treatment. Six patients died during the treatment period, none of them due to complications related to NPWT, and these patients were excluded from analysis of wound healing. In the other 59 treatments, 40 wounds (68%) healed successfully, but healing was incomplete in 19. Treatment related complications were recorded in 19 (32%) cases; wound pain (12%) and skin problems (11%) being the most common ones.
   Conclusion: NPWT has been used considerably in Iceland, especially for infected surgical wounds and chronic wounds. In two thirds of cases a complete wound healing was achieved, which must be regarded as a favorable outcome.
C1 [Guomundsdottir, Ingibjorg] Univ Iceland, Dept Vasc Surg, IS-101 Reykjavik, Iceland.
   [Steingrimsson, Steinn; Guobjartsson, Tomas] Univ Iceland, Landspitali Univ Hosp, IS-101 Reykjavik, Iceland.
   [Guobjartsson, Tomas] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.
C3 University of Iceland; University of Iceland; Landspitali National
   University Hospital; University of Iceland
RP Guobjartsson, T (通讯作者)，Univ Iceland, Dept Vasc Surg, IS-101 Reykjavik, Iceland.
EM tomasgud@landspitali.is
RI Steingrimsson, Steinn/AAF-5475-2021
OI Steingrimsson, Steinn/0000-0001-8320-5607
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Attinger CE, 2006, PLAST RECONSTR SURG, V117, p72S, DOI 10.1097/01.prs.0000225470.42514.8f
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Borgquist O, 2010, ANN PLAS SURG, V64, P789, DOI 10.1097/SAP.0b013e3181ba578a
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Llanos S, 2006, ANN SURG, V244, P700, DOI 10.1097/01.sla.0000217745.56657.e5
   Malmsjö M, 2007, PLAST RECONSTR SURG, V120, P1266, DOI 10.1097/01.prs.0000279326.84535.2d
   Moisidis E, 2004, PLAST RECONSTR SURG, V114, P917, DOI 10.1097/01.PRS.0000133168.57199.E1
   Moues C M, 2005, J Wound Care, V14, P224
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Petzina R, 2010, J THORAC CARDIOV SUR, V140, P1133, DOI 10.1016/j.jtcvs.2010.06.063
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Sjögren J, 2011, INTERACT CARDIOV TH, V12, P117, DOI 10.1510/icvts.2010.252668
   Svensson S, 2008, EUR J VASC ENDOVASC, V36, P84, DOI 10.1016/j.ejvs.2007.12.020
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 19
TC 1
Z9 2
U1 0
U2 3
PU LAEKNAFELAG ISLANDS-ICELANDIC MEDICAL ASSOC
PI KOPAVOGUR
PA HLIDASMARI 8, KOPAVOGUR, 200, ICELAND
SN 0023-7213
EI 1670-4959
J9 LAEKNABLADID
JI Laeknabladid
PD MAR
PY 2012
VL 98
IS 3
BP 149
EP 153
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 920FT
UT WOS:000302389800004
PM 22450519
OA gold
DA 2026-07-24
ER

PT J
AU Toz, H
   Kuserli, Y
   Türkyilmaz, G
   Kavala, AA
   Türkyilmaz, S
AF Toz, Hasan
   Kuserli, Yusuf
   Turkyilmaz, Gulsum
   Kavala, Ali Aycan
   Turkyilmaz, Saygin
TI Comparison of treatment approaches for mediastinitis after coronary
   artery bypass grafting: Negative pressure wound therapy versus
   conventional methods
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA Turkish
DT Article
DE Coronary artery bypass grafting; mediastinitis; negative-pressure wound
   therapy; postoperative complications; wound healing
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY;
   POSTOPERATIVE MEDIASTINITIS; STERNOTOMY; INFECTION; RECONSTRUCTION;
   UNIVERSITY; DRAINAGE; SAFETY
AB Background: This study aims to compare the effectiveness of negative-pressure wound therapy (NPWT) compared to conventional methods for the treatment of mediastinitis following coronary artery bypass grafting. Methods: Between January 2010 and January 2023, a total of 87 patients (47 males, 40 females; mean age: 62.0 +/- 10.2 years; range, 35 to 80 years) who developed mediastinitis following sternotomy were retrospectively analyzed. The patients were divided into two groups: those treated with conventional methods (n=39) from January 2010 to February 2015 and those treated with NPWT (n=48) from March 2015 to January 2023. Clinical outcomes, including treatment duration, infection resolution time, hospital stay, and mortality rate, were recorded. Results: The NPWT group had significantly shorter treatment durations (20.1 +/- 4.0 days) than the conventional group (58.6 +/- 17.1 days, p<0.001). The time to achieve negative cultures was also significantly reduced in the NPWT group (15.3 +/- 3.6 days) compared to the conventional group (36.7 +/- 8.1 days, p<0.001). The length of hospital stay was shorter in the NPWT group (34.3 +/- 12.8 days) compared to the conventional group (88.0 +/- 21.1 days, p<0.001). The NPWT group had a lower hospital mortality rate (4.2%) than the conventional group (17.9%, p=0.049). Conclusion: The NPWT demonstrated superior efficacy in managing postoperative mediastinitis compared to conventional methods, highlighting its potential as a preferred treatment option for this serious complication.
C1 [Toz, Hasan; Kuserli, Yusuf; Turkyilmaz, Gulsum; Kavala, Ali Aycan; Turkyilmaz, Saygin] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkiye.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Toz, H (通讯作者)，Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiovasc Surg, Istanbul, Turkiye.
EM tozhasan@hotmail.com
RI /AAO-8346-2021; Kavala, Ali Aycan/KEI-8579-2024; TÜRKYILMAZ,
   SAYGIN/AGT-8514-2022
OI Toz, Hasan/0000-0002-4228-6233; Kavala, Ali Aycan/0000-0001-6881-4439;
   TÜRKYILMAZ, SAYGIN/0000-0003-2165-6853
CR Akbayrak H, 2023, BRAZ J CARDIOV SURG, V38, P353, DOI 10.21470/1678-9741-2022-0317
   Akyildiz Ö, 2022, ULUS TRAVMA ACIL CER, V28, P180, DOI 10.14744/tjtes.2020.13546
   Älgå A, 2022, WORLD J EMERG SURG, V17, DOI 10.1186/s13017-022-00415-1
   ANSI/ASHRAE/ASHE, 2013, Standard 170-2013 ventilation of health care facilities
   Badawy Mohamed Abdelrahman, 2014, Asian Cardiovasc Thorac Ann, V22, P649, DOI 10.1177/0218492314536106
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Pagotto VPF, 2021, BRAZ J CARDIOV SURG, V36, P565, DOI 10.21470/1678-9741-2020-0117
   Gårdlund B, 2002, EUR J CARDIO-THORAC, V21, P825, DOI 10.1016/S1010-7940(02)00084-2
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   Lee AJ, 2017, INTERACT CARDIOV TH, V24, P324, DOI 10.1093/icvts/ivw400
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nakamori Y, 2004, AM J ROENTGENOL, V182, P1443, DOI 10.2214/ajr.182.6.1821443
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   Risnes I, 2010, ANN THORAC SURG, V89, P1502, DOI 10.1016/j.athoracsur.2010.02.038
   Sahin MF, 2022, TURK GOGUS KALP DAMA, V30, P57, DOI [10.5606/tgkdc.dergisi.2022.20958, 10.5606/tgkdc.dergisi.2022.20958, 10.5606/tgkdc.dergisi.2022.2095]
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   SARR MG, 1984, ANN THORAC SURG, V38, P415, DOI 10.1016/S0003-4975(10)62300-4
   Sjögren J, 2005, ANN THORAC SURG, V79, P2049, DOI 10.1016/j.athoracsur.2004.12.048
   Sjögren J, 2006, EUR J CARDIO-THORAC, V30, P898, DOI 10.1016/j.ejcts.2006.09.020
   Trouillet JL, 2005, J THORAC CARDIOV SUR, V129, P518, DOI 10.1016/j.jtcvs.2004.07.027
   Vettath MP, 2018, HEART SURG FORUM, V21, pE151, DOI 10.1532/hsf.2007
   Yu AW, 2013, INTERACT CARDIOV TH, V17, P861, DOI 10.1093/icvts/ivt326
NR 28
TC 1
Z9 1
U1 0
U2 1
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   Turkiye
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD OCT
PY 2025
VL 33
IS 4
BP 412
EP 422
DI 10.5606/tgkdc.dergisi.2025.28035
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9JL4T
UT WOS:001607812900004
PM 41510548
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Ahmed, MSA
   Hassan, MIM
   Ibrahim, A
   Lamey, A
   Elsayed, MM
   Elshaboury, A
   Elkasaby, MH
   Abdelrafee, A
AF Ahmed, Mohamed Sherif Ali
   Hassan, Mostafa Ismail Mahmoud
   Ibrahim, Ahmed
   Lamey, Ahmed
   Elsayed, Mahmoud M.
   Elshaboury, Ahmed
   Elkasaby, Mohamed Hamouda
   Abdelrafee, Ahmed
TI Effect of negative pressure wound therapy on surgical wound outcomes in
   colorectal cancer surgery patients: a systematic review and
   meta-analysis
SO BMC SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy; NPWT; Colorectal Cancer Surgery;
   Surgical Site Infection; and Wound Complications
ID VACUUM-ASSISTED CLOSURE; SITE INFECTIONS; COMPLICATIONS; PREVENTION;
   RESECTION; COLON
AB Background Surgical site infections (SSI) and wound complications are major concerns in colorectal cancer (CRC) surgery. Negative pressure wound therapy (NPWT) has been proposed to reduce these complications, but its efficacy specifically in CRC surgery remains uncertain. This meta-analysis evaluates the impact of NPWT on surgical wound outcomes compared to standard wound care in patients undergoing CRC surgery. Methods A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted up to February 10, 2025, for studies comparing NPWT with standard wound care in CRC surgery patients. The primary outcome was total wound complications. Risk ratios (RR) and mean differences (MD) were pooled using a random-effects model, with heterogeneity assessed using I & sup2; statistics. Results Six studies involving 343 patients (NPWT: 171, control: 172) were included. NPWT did not significantly reduce total wound complications (RR: 0.67, 95% CI: 0.35-1.26, P = 0.21, I & sup2; = 66%). Similarly, no significant differences were found for SSI (RR: 0.80, 95% CI: 0.45-1.43, P = 0.45), even after sensitivity analysis resolved heterogeneity (RR: 0.62, 95% CI: 0.33-1.17, P = 0.14, I & sup2; = 0%). NPWT also showed no significant benefit in preventing wound dehiscence (RR: 2.44, P = 0.35), seroma (RR: 0.87, P = 0.92), or reducing reintervention rates (RR: 0.69, P = 0.36). The length of hospital stay was comparable between groups (MD: -0.25 days, P = 0.80). Conclusion This meta-analysis suggests that NPWT does not significantly reduce wound complications, SSI, or LOS in CRC surgery.
C1 [Ahmed, Mohamed Sherif Ali; Hassan, Mostafa Ismail Mahmoud; Ibrahim, Ahmed; Elshaboury, Ahmed] Mansoura Univ Hosp, Al Mansurah, Egypt.
   [Lamey, Ahmed] Kafr Elsheikh Univ, Fac Med, Dept Gen Surg, Kafr Al Sheikh, Egypt.
   [Elsayed, Mahmoud M.] Med Univ South Carolina, Neurosurg Dept, Charleston, SC USA.
   [Elkasaby, Mohamed Hamouda] Al Azhar Univ, Fac Med, Cairo, Egypt.
   [Abdelrafee, Ahmed] Mansoura Univ, Fac Med, Gastrointestinal Surg Ctr, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Kafrelsheikh University; Medical University of South
   Carolina; Egyptian Knowledge Bank (EKB); Al Azhar University; Egyptian
   Knowledge Bank (EKB); Mansoura University
RP Ahmed, MSA (通讯作者)，Mansoura Univ Hosp, Al Mansurah, Egypt.
EM mohamedsherifaliahmed@gmail.com
RI Lamey, Ahmed/JWA-5019-2024; Ahmed, Mohamed Sherif Ali/MCJ-0437-2025;
   Abdelrafee, Ahmed/S-4009-2018; Hassan, Mostafa Elsayed/ABB-1736-2021
OI Elkasaby, Mohamed Hamouda/0000-0003-1092-7144; 
FU Mansoura University
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB).
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 11
PY 2026
VL 26
IS 1
AR 278
DI 10.1186/s12893-026-03652-2
EA APR 2026
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GR5EV
UT WOS:001743323900001
PM 41963884
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Gegouskov, V
   Manchev, G
   Goranovska, V
   Stoykov, D
AF Gegouskov, Vassil
   Manchev, Georgi
   Goranovska, Valya
   Stoykov, Dimitar
TI Negative Pressure Wound Therapy Becomes the Treatment of Choice of Deep
   Sternal Wound Infection
SO HEART SURGERY FORUM
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; MEDIASTINITIS; MORTALITY; RISK
AB Background: Sternal wound infection, especially deep sternal wound infection, is a serious complication after open heart surgery. It leads to a marked increase in hospital stay, financial expenses, and mortality. Treatment is primarily surgical and may be divided into conventional treatment methods and negative pressure wound therapy.
   Materials and methods: Between 2010 and 2021, 77 patients presenting back after cardiac surgery with deep sternal wound infection were treated surgically. Conventional treatment methods were utilized in 45 patients and included wound revision with primary closure, continuous wound irrigation, and open treatment with secondary closure. Negative-pressure wound therapy (NPWT) was applied in 32 patients. The two treatment arms were compared by two primary outcomes - rate of recurrent infection and hospital mortality. Predictors of mortality and infectious recurrence were identified using multivariate logistic regression.
   Results: Recurrent infection occurred in 18.2% of cases and mortality was 13% in the whole group. NPWT was more successful in preventing recurrent infection OR: 5.4 (95% CI: 1.1-27.5; P = 0.044) than conventional treatment and more than moderate left ventricular systolic dysfunction (EF<40%) predisposed to infectious recurrence - OR: 4.7 (95% CI: 1.05-22.1; P = 0.049). Recurrent infection itself was the strongest predictor of mortality in the multivariate model OR: 0.14 (95% CI: 0.03 - 0.58; P = 0.007).
   Conclusion: NPWT as an initial method of wound preconditioning followed by definitive wound closure effectively reduces the rate of infectious recurrence and patient mortality. It may become the modality of first choice when dealing with complicated incisional infections following heart surgery.
C1 [Gegouskov, Vassil; Manchev, Georgi; Goranovska, Valya] St Anna Univ Hosp, Dept Cardiac Surg, Sofia, Bulgaria.
   [Stoykov, Dimitar] Georgi Stranski Univ Hosp, Dept Surg, Pleven, Bulgaria.
   [Gegouskov, Vassil; Stoykov, Dimitar] Med Univ Pleven, Pleven, Bulgaria.
C3 Medical University Sofia; Medical University Pleven
RP Manchev, G (通讯作者)，St Anna Univ Hosp, Dept Cardiac Surg, Sofia, Bulgaria.
EM georgi.manchev@ymail.com
RI Manchev, Georgi/JVD-5199-2023
OI Manchev, Georgi/0000-0001-8643-0922
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NR 36
TC 3
Z9 3
U1 0
U2 2
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PY 2022
VL 25
IS 4
BP E601
EP E607
DI 10.1532/hsf.4791
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 3Z0IP
UT WOS:000844104900002
PM 36052909
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pawar, DRL
   Mitchell, SJ
   Jeyapalina, S
   Hawkes, JE
   Florell, SR
   Bachus, KN
AF Pawar, Divya R. L.
   Mitchell, Saranne J.
   Jeyapalina, Sujee
   Hawkes, Jason E.
   Florell, Scott R.
   Bachus, Kent N.
TI Peri-prosthetic tissue reaction to discontinuation of negative pressure
   wound therapy around porous titanium percutaneous devices
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE negative-pressure wound therapy; percutaneous devices; epithelial
   downgrowth; wound healing; peri-prosthetic tissue
ID VACUUM-ASSISTED CLOSURE; TRANSCUTANEOUS IMPLANTS; MODEL; BONE;
   INFLAMMATION; CONTRACTION; MECHANISMS; BARRIER; REPAIR; PIG
AB Negative pressure wound therapy (NPWT) has been reported to limit epithelial downgrowth, one of the failure mechanisms of percutaneous devices. In a previous study, when NPWT was applied for 4 weeks (NPWT Group) to porous coated titanium percutaneous devices, downgrowth (5 +/- 4%; mean +/- one SD) was significantly reduced compared to untreated controls (Untreated Group) (16 +/- 6%; p0.01). However, it was unclear whether this beneficial effect was sustained when NPWT was discontinued. In order to test this, porous coated titanium percutaneous devices were implanted into 6 hairless guinea pigs. Post-surgery, animals received 4 weeks of NPWT treatment followed by 4 weeks of no treatment (Discontinued Group). At necropsy, the devices and surrounding tissues were harvested and processed. Quantitative downgrowth measurements and qualitative analyses of tissue characteristics were performed, and compared to historical controls (NPWT and Untreated Groups). The Discontinued Group, at 8 weeks, had significantly more downgrowth than the NPWT Group at 4 weeks (23 +/- 3% vs. 5 +/- 4%; p0.01). At 8 weeks, the Discontinued Group qualitatively appeared to exhibit reduced numbers of blood vessels and increased degree of fibrosis compared to the NPWT Group at 4 weeks. This study suggests that NPWT will only be an effective treatment for limiting downgrowth if used continuously. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 564-572, 2019.
C1 [Pawar, Divya R. L.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Orthopaed Ctr, Salt Lake City, UT 84148 USA.
   [Pawar, Divya R. L.; Mitchell, Saranne J.; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Jeyapalina, Sujee] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT 84132 USA.
   [Hawkes, Jason E.; Florell, Scott R.] Univ Utah, Sch Med, Dept Dermatol, Salt Lake City, UT 84132 USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, George E Wahlen Dept Vet Affairs Med Ctr, Orthopaed Res Labs, Orthopaed Ctr, Salt Lake City, UT 84148 USA.; Bachus, KN (通讯作者)，Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
EM kent.bachus@va.gov
RI ; Bachus, Kent/KYO-7869-2024
OI Mitchell, Saranne J/0000-0002-6473-7648; 
FU US Army Medical Research and Materiel Command [W81XWH-15-C-0058];
   Department of Defense [W81XWH-11-1-0435]; United States Department of
   Veterans Affairs Rehabilitation Research and Development Service
   [I01RX001217, I01RX001246]; Department of Orthopaedics, University of
   Utah School of Medicine
FX Contract grant sponsor: US Army Medical Research and Materiel Command;
   contract grant number: W81XWH-15-C-0058Contract grant sponsor:
   Department of Defense; contract grant number: W81XWH-11-1-0435Contract
   grant sponsor: United States Department of Veterans Affairs
   Rehabilitation Research and Development Service; contract grant numbers:
   I01RX001217; I01RX001246Contract grant sponsor: Department of
   Orthopaedics, University of Utah School of Medicine
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 36
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD APR
PY 2019
VL 107
IS 3
BP 564
EP 572
DI 10.1002/jbm.b.34148
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA HP4YX
UT WOS:000461683400010
PM 29732684
OA Bronze
DA 2026-07-24
ER

PT J
AU Yu, YC
   Song, ZG
   Xu, ZY
   Ye, XF
   Xue, CY
   Li, JH
   Bi, HD
AF Yu, Yongchao
   Song, Zhigang
   Xu, Zhiyun
   Ye, Xiaofei
   Xue, Chunyu
   Li, Junhui
   Bi, Hongda
TI Bilayered negative-pressure wound therapy preventing leg incision
   morbidity in coronary artery bypass graft patients A randomized
   controlled trial
SO MEDICINE
LA English
DT Article
DE bilayered negative pressure wound therapy (b-NPWT); coronary artery
   bypass graft (CABG); great saphenous veins; lymphorrhagia
ID VACUUM-ASSISTED CLOSURE; LYMPH-NODE DISSECTION; INTERNAL THORACIC
   ARTERY; MICROVASCULAR BLOOD-FLOW; COMPLICATIONS
AB Backgrounds: The harvesting of great saphenous veins for coronary artery bypass graft (CABG) patients may result in significant complications, including lymphorrhagia, lymphoedema, incision infection, wound dehiscence, and skin flap necrosis. We investigated the function of a self-designed bilayered negative pressure wound therapy (b-NPWT) for reducing the above-mentioned complications using a clinical randomized controlled trial.
   Methods: A single-center, pilot randomized controlled trial was conducted. From December 2013 to March 2014, a total of 72 coronary heart disease patients (48 men and 24 women) received CABG therapy, with great saphenous veins were selected as grafts. Patients were equally randomized into a treatment and a control group. After the harvesting of the great saphenous veins and direct closure of the wound with sutures, b-NPWT was used for the thigh incision in the treatment group for 5 days (treatment thigh). Traditional surgical pads were applied to both the shank incisions of the treatment group patients (treatment shank) and the entire incisions of the control group (control thigh, control shank). Postoperative complications were recorded and statistically analyzed based on outcomes of thigh treatment, shank treatment, thigh control, and shank control groups.
   Results: The incidence rates of early complications, such as lymphorrhagia, lymphoedema, infection, wound dehiscence, and skin flap necrosis, of the vascular donor site in the thigh treatment group was significantly lower than those in the 3 other groups.
   Conclusions: The self-designed b-NPWT can effectively reduce postoperative complications, such as lymphedema, incision infection, wound dehiscence, and skin flap necrosis, in CABG patients who underwent great saphenous veins harvesting.
C1 [Yu, Yongchao; Song, Zhigang; Xu, Zhiyun] Second Mil Med Univ, Changhai Hosp, Dept Cardiac Surg, Shanghai 200433, Peoples R China.
   [Ye, Xiaofei] Second Mil Med Univ, Changhai Hosp, Dept Stat, Fac Med Serv, Shanghai 200433, Peoples R China.
   [Xue, Chunyu; Li, Junhui; Bi, Hongda] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University
RP Xue, CY; Li, JH; Bi, HD (通讯作者)，Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, 168 Changhai Rd, Shanghai 200433, Peoples R China.
EM xcyfun@sina.com; Lissot@163.com; bihongda0411@163.com
OI ye, xiaofei/0000-0003-3692-1285
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 35
TC 11
Z9 13
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2017
VL 96
IS 3
AR e5925
DI 10.1097/MD.0000000000005925
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EI4TR
UT WOS:000392486800031
PM 28099357
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Condé-Green, A
   Chung, TL
   Holton, LH
   Hui-Chou, HG
   Zhu, Y
   Wang, H
   Zahiri, H
   Singh, DP
AF Conde-Green, Alexandra
   Chung, Thomas L.
   Holton, Luther H., III
   Hui-Chou, Helen G.
   Zhu, Yue
   Wang, Howard
   Zahiri, Hamid
   Singh, Devinder P.
TI Incisional Negative-Pressure Wound Therapy Versus Conventional Dressings
   Following Abdominal Wall Reconstruction A Comparative Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE incisional negative-pressure wound therapy; abdominal wall
   reconstruction; conventional dry gauze dressings; outcomes
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT
AB Background: Improvements in surgical techniques have allowed us to achieve primary closure in a high percentage of large abdominal hernia repairs. However, postoperative wound complications remain common. The benefits of negative-pressure wound therapy (NPWT) in the management of open abdominal wounds are well described in the literature. Our study investigates the effects of incisional NPWT after primary closure of the abdominal wall.
   Methods: A retrospective chart review was performed for the period between September 2008 and May 2011 to analyze the outcomes of patients treated postoperatively with incisional NPWT versus conventional dry gauze dressings. Patient information collected included history of abdominal surgeries, smoking status, and body mass index. Postoperative complications were analyzed using W 2 exact test and logistic regression analysis.
   Results: Fifty-six patients were included in this study; of them, 23 were treated with incisional NPWT, whereas 33 received conventional dressings. The rates of overall wound complications in groups I and II were 22% and 63.6%, respectively (P = 0.020). The rates of skin dehiscence were 9% and 39%, respectively (P = 0.014). Both outcomes achieved statistical significance. Rates of infection, skin and fat necrosis, seroma, and hernia recurrence were 4%, 9%, 0%, and 4% for group I and 6%, 18%, 12%, 9% for group II, respectively.
   Conclusions: This study suggests that incisional NPWT following abdominal wall reconstruction significantly improves rates of wound complication and skin dehiscence when compared with conventional dressings. Prospective, randomized, controlled studies are needed to further characterize the potential benefits of this therapy on wound healing after abdominal wall reconstruction.
C1 [Conde-Green, Alexandra; Chung, Thomas L.; Holton, Luther H., III; Hui-Chou, Helen G.; Singh, Devinder P.] Univ Maryland, Med Ctr, Div Plast Surg, Baltimore, MD 21201 USA.
   [Zhu, Yue; Zahiri, Hamid] Univ Maryland, Med Ctr, Dept Surg, Baltimore, MD 21201 USA.
   [Wang, Howard] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore
RP Condé-Green, A (通讯作者)，Univ Maryland, Med Ctr, Div Plast Surg, Room S8D18,22 South Greene St, Baltimore, MD 21201 USA.
EM acondegreen@yahoo.com
RI Hui-Chou, Helen/AHE-3492-2022; Singh, Devinder/AAN-4716-2021
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 19
TC 118
Z9 144
U1 1
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD OCT
PY 2013
VL 71
IS 4
BP 394
EP 397
DI 10.1097/SAP.0b013e31824c9073
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 300GX
UT WOS:000330453500017
PM 22868327
DA 2026-07-24
ER

PT J
AU Yao, XF
   Wang, YJ
   Lin, YS
AF Yao, Xiao-Feng
   Wang, Yen-Jen
   Lin, Yang-Sheng
TI Palliative care with negative pressure wound therapy application in
   malignant wounds: a systematic review
SO JOURNAL OF WOUND CARE
LA English
DT Review
DE malignancy; malignant wound; negative pressure wound therapy; palliative
   care; quality of life; wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; COMPLICATIONS; RESECTION; BIOFILMS;
   QUALITY
AB Objective: To synthesise and appraise the evidence for and benefits of palliative application of negative pressure wound therapy (NPWT) in malignant wounds. Method: We performed a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). MEDLINE, Embase, Cochrane Library and trial registers (www.clinicaltrials.gov) from inception to 1 June 2021 were searched. Quality was assessed using the tool of methodological quality and synthesis from the 2018 BMJ Evidence-Based Medicine article on case series and case report synthesis. Results: Of 765 articles screened, 14 eligible studies were included in the review. All were case reports and included a total of 22 patients. The mean age of the patients was 60.7 (range: 33-77) years. The location of the hard-to-heal wounds was widely distributed: five wounds on the scalp; three wounds over the anogenital area; and the remaining wounds on the trunk and extremities. The reported outcomes included: improvement of wound healing; decreased exudation and malodour of the wound; decreased pain sensation; eligibility for further treatment; and a shift to the homecare system. Conclusion: The findings of this study suggested NPWT could be a choice in palliative care for patients with malignant wounds. However, more studies are needed to evaluate the efficacy of NPWT in these wounds. Declaration of interest: The authors have no conflicts of interest to declare. The authors declare amendments to the protocol (PROSPERO number CRD42020214516), which included performing an additional search three months prior to submission.
C1 [Yao, Xiao-Feng; Wang, Yen-Jen] MacKay Mem Hosp, Dept Dermatol, Taipei, Taiwan.
   [Wang, Yen-Jen] MacKay Jr Coll Med Nursing & Management, Dept Cosmet Applicat & Management, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Med Coll, Dept Med, New Taipei City, Taiwan.
   [Lin, Yang-Sheng] Mackay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.
   [Lin, Yang-Sheng] MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.
   [Lin, Yang-Sheng] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Junior College of Medicine, Nursing &
   Management; Mackay Medical University; Mackay Memorial Hospital; Mackay
   Memorial Hospital; Taipei Medical University
RP Lin, YS (通讯作者)，MacKay Med Coll, Dept Med, New Taipei City, Taiwan.; Lin, YS (通讯作者)，Mackay Mem Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.; Lin, YS (通讯作者)，MacKay Mem Hosp, Evidence Based Med Ctr, Taipei, Taiwan.; Lin, YS (通讯作者)，Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan.
EM d118107002@tmu.edu.tw
OI Wang, Yen-Jen/0000-0002-0425-9154
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NR 67
TC 0
Z9 0
U1 2
U2 6
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2025
VL 34
IS 4
BP 304
EP 311
DI 10.12968/jowc.2021.0254
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1SQ3W
UT WOS:001472700300007
PM 40227927
DA 2026-07-24
ER

PT J
AU Borgquist, O
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Ingemansson, Richard
   Malmsjo, Malin
TI Individualizing the Use of Negative Pressure Wound Therapy for Optimal
   Wound Healing: A Focused Review of the Literature
SO OSTOMY WOUND MANAGEMENT
LA English
DT Review
DE literature review; negative pressure wound therapy; gauze; foam;
   pressure settings
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; PROSPECTIVE
   RANDOMIZED-TRIAL; IMPROVING GRAFT-SURVIVAL; SECURING SKIN-GRAFTS;
   ENDOTHELIAL-CELLS; GAUZE; PROGRESSION; ULCERS; TRANSDUCTION
AB Currently available research suggests that negative pressure wound therapy (NPWT) creates a moist wound healing environment, drains exudate, reduces tissue edema, contracts the wound edges, mechanically stimulates the wound bed, and influences blood perfusion at the wound edge, which may lead to angiogenesis and the formation of granulation tissue. Although no clear evidence is available that NPWT accelerates wound healing compared to other interventions or that one form of NPWT is better than another, preclinical research suggests that the most commonly used dressings, level of negative pressure, and application mode (continuous, intermittent, or variable) may not be optimal for all patients. To summarize available literature related to these NPWT choices, pertinent literature published between 2005 and 2010 was reviewed. Preclinical study results suggest that the maximal biological effect of NPWT at the wound edge often can be achieved at -80 mm Hg and that foam dressings may be advantageous for large defect wounds, whereas gauze dressings may be more suitable for smaller wounds or when scar formation or pain is a concern. Preclinical research results also suggest that intermittent or variable pressure application has a better effect on granulation tissue formation than continuous application. The variable pressure mode maintains a negative pressure environment at lower pressure settings without dramatic fluctuations inherent to intermittent (on-and-off) pressure. Prospective, controlled clinical studies are needed to compare NPWT to other advanced wound care protocols of care and to ascertain the effect of various NPWT methods and regimens on outcomes of care.
C1 [Borgquist, Ola; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
C3 Lund University; Lund University; Lund University; Lund University;
   Skane University Hospital
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeansson Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation; Prospera (Fort Worth, TX)
FX The work was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, Lars Hierta's Memorial Foundation, and
   Prospera (Fort Worth, TX).
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NR 67
TC 41
Z9 52
U1 1
U2 17
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD APR
PY 2011
VL 57
IS 4
BP 44
EP +
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 752QO
UT WOS:000289707700013
PM 21512192
DA 2026-07-24
ER

PT J
AU Vidalis, BM
   Ngwudike, S
   McCandless, MG
   Chohan, MO
AF Vidalis, Benjamin M.
   Ngwudike, Somtochukwu, I
   McCandless, Martin G.
   Chohan, Muhammad O.
TI Negative Pressure Wound Therapy in Facilitating Wound Healing After
   Surgical Decompression for Metastatic Spine Disease
SO WORLD NEUROSURGERY
LA English
DT Article
DE Metastatic spine disease; Negative pressure wound therapy; Surgical site
   infection
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; RISK-FACTORS; SURGERY;
   COMPLICATIONS; MANAGEMENT
AB BACKGROUND: The risk of wound-related complications, including surgical site infections (SSIs), in patients undergoing surgery for metastatic spine disease (MSD) is high. Consequently, patients requiring wound revision surgery face delay in resuming oncological care and incur additional hospitalization. Recent reports suggest that negative pressure wound therapy (NPWT) applied on a closed wound at the time of surgery significantly reduces postoperative wound complications in degenerative spine disease and trauma setting. Here, we report a single institution experience with incisional NPWT in patients undergoing surgery for MSD.
   METHODS: We compared rates of wound complications requiring surgical revision in a surgical cohort of patients with or without NPWT from 2015 to 2020. Adult patients with radiographic evidence of MSD with mechanical instability and/or accelerated neurological decline were included in the study. NPWT was applied on a closed wound in the operating room and continued for 5 days or until discharge, whichever occurred first.
   RESULTS: A total of 42 patients were included: 28 with NPWT and 14 without. Patient demographics including underlying comorbidities were largely similar. NPWT patients had higher rates of prior radiation to the surgical site (36% vs. 0%, P = 0.017) and longer fusion constructs (6.7 vs. 3.9 levels, P < 0.001). Three patients (21%) from the control group and none from the NPWT group contracted SSI requiring wound washout (P = 0.032).
   CONCLUSIONS: Our data suggest that SSI and wound dehiscence are significantly reduced with the addition of incisional NPWT in this vulnerable population.
C1 [Vidalis, Benjamin M.; Chohan, Muhammad O.] Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA.
   [Ngwudike, Somtochukwu, I; McCandless, Martin G.; Chohan, Muhammad O.] Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA.
C3 University of New Mexico; University of Mississippi Medical Center;
   University of Mississippi
RP Chohan, MO (通讯作者)，Univ New Mexico, Dept Neurosurg, Albuquerque, NM 87131 USA.; Chohan, MO (通讯作者)，Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA.
EM mchohan@umc.edu
RI ; Chohan, Muhammad/ABG-1163-2021
OI McCandless, Martin/0000-0002-9068-8683; 
CR Adogwa O, 2014, SPINE J, V14, P2911, DOI 10.1016/j.spinee.2014.04.011
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NR 37
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD MAR
PY 2022
VL 159
BP E407
EP E415
DI 10.1016/j.wneu.2021.12.063
EA MAR 2022
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 2P6JU
UT WOS:000819845600023
PM 34954060
DA 2026-07-24
ER

PT J
AU Shah, A
   Sumpio, BJ
   Tsay, C
   Swallow, M
   Dash, B
   Thorn, SL
   Sinusas, AJ
   Koo, A
   Hsia, HC
   Au, A
AF Shah, Ajul
   Sumpio, Brandon J.
   Tsay, Cynthia
   Swallow, Matthew
   Dash, Biraja
   Thorn, Stephanie L.
   Sinusas, Albert J.
   Koo, Andrew
   Hsia, Henry C.
   Au, Alexander
TI Incisional Negative Pressure Wound Therapy Augments Perfusion and
   Improves Wound Healing in a Swine Model Pilot Study
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE perfusion; flap; wound healing; negative pressure wound therapy;
   incision; incisional VAC; VAC; externa VAC
ID VACUUM-ASSISTED CLOSURE; ENDOTHELIAL GROWTH-FACTOR; GRANULATION-TISSUE;
   ANGIOGENESIS; MANAGEMENT; INHIBITOR; SURGERY
AB Background: A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been used to optimize wound healing in the setting of surgically closed wounds; however, the specific mechanisms of action by which NPWT may benefit patients after surgery remain unknown. Using a swine wound healing model, the current study investigates angiogenesis as a candidate mechanism.
   Methods: Multiple excisional wounds were created on the dorsa of 10 male Yorkshire pigs and closed by primary suture. The closed wounds underwent treatment with either NPWT dressing or control dressings in the absence of negative pressure. Dressings were maintained for 8 days followed by euthanasia of the animal. Scar evaluation of the wounds by photographic analysis was performed, and wounds were analyzed for angiogenesis markers by enzyme-linked immunosorbent assay and immunohistochemistry.
   Results: Scar evaluation scores were observed to be significantly higher for the NPWT-treated sites compared with the control sites (P < 0.05). The enzyme-linked immunosorbent assay results demonstrated increases for vascular endothelial growth factor (VEGF) staining at the incision site treated with NPWT compared with other treatment groups (P < 0.05). In addition, an approximately 3-fold elevation in VEGF expression was observed at the NPWT-treated sites (2.8% vs. 1%, respectively; P < 0.0001).). However, there was no significant difference in immunohistochemistry staining.
   Conclusions: The use of NPWT improves the appearance of wounds and appears to increase VEGF expression after 8 days in the setting of a closed excisional wound model, suggesting that improved angiogenesis is one mechanism by which NPWT optimizes wound healing when applied to closed surgical wound sites.
C1 [Shah, Ajul; Sumpio, Brandon J.; Tsay, Cynthia; Swallow, Matthew; Dash, Biraja; Koo, Andrew; Hsia, Henry C.] Yale Univ, Sch Med, Dept Surg, Sect Plast Surg, New Haven, CT 06510 USA.
   [Thorn, Stephanie L.; Sinusas, Albert J.] Yale Univ, Sch Med, Dept Med, Sect Cardiovasc Med, New Haven, CT 06510 USA.
   [Au, Alexander] Univ Penn, Sch Med, Dept Plast Surg, Philadelphia, PA 19104 USA.
C3 Yale University; Yale University; University of Pennsylvania
RP Hsia, HC (通讯作者)，Yale Univ, Sch Med, Sect Plast Surg, Boardman Bldg 3rd Floor,330 Cedar St, New Haven, CT 06510 USA.
EM henry.hsia@yale.edu
RI Sinusas, Albert/A-7235-2009; Koo, Andrew/LYO-4529-2024; Dash,
   Biraja/B-3966-2018; Hsia, Henry/W-6140-2019; Thorn,
   Stephanie/AAD-6988-2022
OI Thorn, Stephanie/0000-0003-0020-0814
FU Kinetic Concepts Inc.
FX This work was supported by grant funding from Kinetic Concepts Inc. All
   authors have no commercial associations or disclosures that may pose or
   create a conflict of interest with the information presented within this
   article. The authors declare no conflict of interest.
CR Agarwal JP, 2005, PLAST RECONSTR SURG, V116, P1035, DOI 10.1097/01.prs.0000178401.52143.32
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NR 29
TC 29
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD APR
PY 2019
VL 82
SU 3
BP S222
EP S227
DI 10.1097/SAP.0000000000001842
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IF7QP
UT WOS:000473279100013
PM 30855392
DA 2026-07-24
ER

PT J
AU Lerman, B
   Oldenbrook, L
   Eichstadt, SL
   Ryu, J
   Fong, KD
   Schubart, PJ
AF Lerman, Bruce
   Oldenbrook, Leslie
   Eichstadt, Shaundra L.
   Ryu, Justin
   Fong, Kenton D.
   Schubart, Peter J.
TI Evaluation of Chronic Wound Treatment with the SNaP Wound Care System
   versus Modern Dressing Protocols
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; STATE
AB Background: Traditional negative-pressure wound therapy systems use an electrically powered pump to generate negative pressure at the wound bed. The SNaP Wound Care System is a novel, ultraportable device that delivers negative-pressure wound therapy without the use of an electrically powered pump.
   Methods: At an outpatient wound care clinic, 21 subjects with difficult-to-treat lower extremity ulcers received treatment with the SNaP System and were evaluated for wound healing for up to 4 months. Outcomes were then compared with 42 patient-matched controls treated at the same center with modern wound care protocols that included the use of Apligraf, Regranex, and skin grafting.
   Results: In the SNaP-treated group, 100 percent of subjects demonstrated improvement in wound size and 86 percent (18 of 21) exhibited a statistically significant healing trend (p < 0.05). Using Kaplan-Meier estimates of wound healing, SNaP-treated subjects healed in an average of 74.25 +/- 20.1 days from the start of SNaP treatment and the matched controls healed in an average of 148.73 +/- 63.1 days from the start of conventional treatment. This significantly faster healing time represents a 50 percent absolute reduction in time to healing (p < 0.0001) for subjects treated with the SNaP device.
   Conclusions: The findings reported here for the SNaP Wound Care System are similar to published reports for powered negative-pressure wound therapy devices for the treatment of highly challenging lower extremity wounds. This study suggests that the SNaP Wound Care System may be a useful addition to the techniques available to the wound care clinician. (Mast. Reconstr. Stew. 126: 1253, 2010.)
C1 [Schubart, Peter J.] OConnor Hosp, OConnor Wound Care Clin, San Jose, CA 95128 USA.
   Stanford Univ, Dept Surg, Div Plast & Reconstruct Surg, Sch Med, Stanford, CA 94305 USA.
   Stanford Univ, Div Vasc Surg, Dept Surg, Sch Med, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University
RP Schubart, PJ (通讯作者)，OConnor Hosp, OConnor Wound Care Clin, 125 Ciro Ave,Suite 201, San Jose, CA 95128 USA.
EM schubart@ix.netcom.com
CR Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Barber C, 2008, J Wound Care, V17, P517
   BORGQUIST O, 2009, 24 ANN CLIN S ADV SK
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Capobianco Claire M, 2009, Clin Podiatr Med Surg, V26, P619, DOI 10.1016/j.cpm.2009.08.002
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   FONG KD, WOUNDS IN PRESS
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   Lee E., 1992, STAT METHODS SURVIVA, VSecond
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 12
TC 26
Z9 28
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2010
VL 126
IS 4
BP 1253
EP 1261
DI 10.1097/PRS.0b013e3181ea4559
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 659IB
UT WOS:000282559100011
PM 20885246
DA 2026-07-24
ER

PT J
AU Hou, YF
   Griffin, L
AF Hou, Yuefeng
   Griffin, Leah
TI Comparative Effectiveness of Negative Pressure Wound Therapy with and
   Without Oxidized Regenerated Cellulose/Collagen/Silver-ORC Dressing
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE retrospective; wound healing; granulation tissue; negative pressure
   wound therapy
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; PROTEASES; STATE
AB Objective: Negative pressure wound therapy (NPWT) and oxidized regenerated cellulose (ORC)/collagen/silver-ORC (OCSO) dressings have individually demonstrated effectiveness in supporting wound healing, but few studies have examined their combined use. This retrospective data analysis compared wound outcomes following outpatient NPWT with and without OCSO dressings.Approach: A search of deidentified records from the U.S. Wound Registry resulted in 485 cases of wounds managed with NPWT with OCSO dressings. A matched cohort of patients who received NPWT without any collagen dressing (n = 485) was created using propensity scoring. For patients in the NPWT + OCSO group, OCSO was applied topically on or after the day of NPWT initiation and stopped on or before the day of NPWT termination.Results: Wounds managed with NPWT + OCSO were significantly more likely to improve and/or heal compared with wounds that received NPWT alone (p = 0.00029). The relative wound area reduction was 40% for patients receiving NPWT + OCSO, compared with 9% for patients receiving only NPWT (p = 0.0099). The median time to achieve 75-100% granulation coverage with no measurable wound depth was shorter by 8 days with NPWT + OCSO in all wound types (p = 0.00034), and by 14 days in surgical wounds (p = 0.0010), than with NPWT alone.Innovation: This is the first study examining the clinical outcomes associated with the integration of NPWT and OCSO dressings compared with the use of NPWT alone. These data support the novel practice of applying NPWT concurrently with OCSO dressings.Conclusion: This retrospective comparative analysis using real-world data demonstrated improved healing outcomes with integrated use of NPWT with OCSO dressings versus NPWT alone.
C1 [Hou, Yuefeng; Griffin, Leah] Solventum, Maplewood, MN USA.
RP Griffin, L (通讯作者)，Solventum, 12930 Interstate 10, San Antonio, TX 78249 USA.
EM lpgriffin@solventum.com
CR Applewhite Andrew, 2018, Wounds, V30, pS19
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NR 36
TC 2
Z9 2
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN 1
PY 2025
VL 14
IS 6
BP 285
EP 294
DI 10.1089/wound.2023.0128
EA JUL 2024
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3DA2J
UT WOS:001263794300001
PM 38666689
OA hybrid
DA 2026-07-24
ER

PT J
AU Rand, BCC
   Wenke, JC
AF Rand, Ben C. C.
   Wenke, Joseph C.
TI An Effective Negative Pressure Wound Therapy-Compatible Local Antibiotic
   Delivery Device
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE open fracture; infection; negative pressure wound therapy; augmented
   NPWT; local antibiotic delivery
ID VACUUM-ASSISTED CLOSURE; CHITOSAN SPONGES; OPEN FRACTURES; COMBAT;
   MODEL; VANCOMYCIN; EXPERIENCE; INJURIES; OUTCOMES; BEADS
AB Objectives: The current clinical standard for local antibiotic depot is polymethylmethacrylate (PMMA) beads. Unfortunately, these are not ideal and negative pressure wound therapy (NPWT) reduces their limited effectiveness. Recently, a chitosan sponge has been shown to be an effective carrier of antibiotics. Because it acts as a delivery vehicle with increased wound contact area instead of an antibiotic depot, it may be more effective. The objectives of this study were to determine if (1) a chitosan sponge would be more effective than PMMA beads as a local antibiotic delivery device and (2) the chitosan sponge remains an effective method of delivery when used in conjunction with NPWT.
   Methods: Contaminated musculoskeletal wounds were created on the proximal tibia of goats; the animals were assigned to 1 of 4 groups (bead pouch, beads with NPWT, sponge pouch, and sponge with NPWT). The animals were survived for 48 hours, and the bacteria in the wound were quantified. The antibiotic levels in the blood and within the NPWT canisters were measured throughout the study period.
   Results: After treatment, there were significantly fewer bacteria in wounds treated with antibiotic chitosan sponge delivery than antibiotic PMMA bead depot (P < 0.05), and NPWT did not reduce the effectiveness of the chitosan sponge even though large amounts of vancomycin was found in the canisters. The peak serum levels of vancomycin were well below what is considered safe levels.
   Conclusions: Antibiotic delivery to the wound using a chitosan sponge is compatible with NPWT and is more effective than PMMA antibiotic depot. The chitosan sponge works in conjunction with NPWT and may improve the outcomes of open fracture wounds.
C1 [Rand, Ben C. C.; Wenke, Joseph C.] US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
   [Rand, Ben C. C.] Royal Ctr Def Med, Acad Dept Mil Surg, Birmingham, W Midlands, England.
C3 Royal Centre for Defence Medicine
RP Wenke, JC (通讯作者)，US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM joseph.c.wenke.civ@mail.mil
FU Bionova Medical (Germantown, TN); US Army Medical Research and Materiel
   Command Combat Casualty Care Research Program
FX The institution of one or more of the authors (J.C.W.) has received
   funding from Bionova Medical (Germantown, TN) who provided the
   experimental materials and paid for a portion of the study. The majority
   of the study was paid for by intramural funding from the US Army Medical
   Research and Materiel Command Combat Casualty Care Research Program.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 22
TC 10
Z9 12
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD DEC
PY 2017
VL 31
IS 12
BP 631
EP 635
DI 10.1097/BOT.0000000000000988
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA FO2QV
UT WOS:000416625900012
PM 28742785
DA 2026-07-24
ER

PT J
AU Anesäter, E
   Borgquist, O
   Hedström, E
   Waga, J
   Ingemansson, R
   Malmsjö, M
AF Anesater, Erik
   Borgquist, Ola
   Hedstrom, Erik
   Waga, Julia
   Ingemansson, Richard
   Malmsjo, Malin
TI The influence of different sizes and types of wound fillers on wound
   contraction and tissue pressure during negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Experimental surgery; Negative pressure wound therapy; Tissue pressure;
   Wound contraction; Wound healing
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW; GAUZE;
   FOAM
AB Negative pressure wound therapy (NPWT) contracts the wound and alters the pressure in the tissue of the wound edge, which accelerates wound healing. The aim of this study was to examine the effect of the type (foam or gauze) and size (small or large) of wound filler for NPWT on wound contraction and tissue pressure. Negative pressures between -20 and -160 mmHg were applied to a peripheral porcine wound (n = 8). The pressure in the wound edge tissue was measured at distances of 0.1, 0.5, 1.0 and 2.0 cm from the wound edge and the wound diameter was determined. At 0.1 cm from the wound edge, the tissue pressure decreased when NPWT was applied, whereas at 0.5 cm it increased. Tissue pressure was not affected at 1.0 or 2.0 cm from the wound edge. The tissue pressure, at 0.5 cm from the wound edge, was greater when using a small foam than when using than a large foam. Wound contraction was greater when using a small foam than when using a large foam during NPWT. Gauze resulted in an intermediate wound contraction that was not affected by the size of the gauze filler. The use of a small foam to fill the wound causes considerable wound contraction and may thus be used when maximal mechanical stress and granulation tissue formation are desirable. Gauze or large amounts of foam result in less wound contraction which may be beneficial, for example when NPWT causes pain to the patient.
C1 [Anesater, Erik; Borgquist, Ola; Waga, Julia; Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Anesater, Erik; Borgquist, Ola; Hedstrom, Erik; Waga, Julia; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Borgquist, Ola] Lund Univ, Dept Anesthesiol & Intens Care, Lund, Sweden.
   [Hedstrom, Erik] Lund Univ, Dept Clin Physiol, Lund, Sweden.
   [Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University; Lund University
RP Malmsjö, M (通讯作者)，BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Ingemansson, Richard/0000-0001-7623-8953; Maljö,
   Malin/0000-0001-9849-9599; Hedström, Erik/0000-0003-0041-9357; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell P E, 2003, J Wound Care, V12, P22
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   Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
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   Willy C, 2004, ZBL CHIR, V129, pS6
NR 22
TC 27
Z9 31
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2011
VL 8
IS 4
BP 336
EP 342
DI 10.1111/j.1742-481X.2011.00790.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 791HB
UT WOS:000292654600004
PM 21564550
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Zhu, JJ
   Sun, Q
   Xu, WL
   Geng, J
   Feng, Q
   Zhao, ZG
   Li, S
AF Zhu, Junjia
   Sun, Qi
   Xu, Wenlong
   Geng, Jun
   Feng, Qiang
   Zhao, Zhenguo
   Li, Sen
TI Effect of Negative Pressure Wound Therapy on Surgical Site Infections
   following Stoma Reversal in Colorectal Surgery: A Meta-Analysis
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Review
DE Colorectal surgery; stoma reversal; surgical site infection;
   negative-pressure wound therapy; NPWT
ID VACUUM-ASSISTED CLOSURE; PURSESTRING CLOSURE; OSTOMY CLOSURE; ILEOSTOMY;
   PREVENTION; OUTCOMES; RISK; MULTICENTER; MANAGEMENT; GUIDELINE
AB BackgroundSurgical site infections (SSI) are common complications after surgery, which cause other complications and increase medical costs. However, the effect of negative-pressure wound therapy (NPWT) for the prevention of SSI at stoma reversal remains inconclusive, with controversial results. This meta-analysis aimed to evaluate the safety and efficacy of NPWT following stoma reversal in colorectal surgery to prevent SSI and other wound complications.MethodsWe conducted a systematic search of the PubMed, EMBASE, and Cochrane Library databases for articles published up to July 2022 and identified relevant studies reporting the NPWT administration following stoma reversal in colorectal surgery compared with non-pressure dressing. The primary outcome was the incidence of SSI, and the secondary outcomes were hematoma, seroma, and length of hospital stay (LOS).ResultsNine studies were included in the meta-analysis, with 825 patients with (n = 310) or without (n = 515) NPWT. Pooled SSI rate was lower in the NPWT group than in the non-pressure dressing group (OR = 0.50; 95% CI: 0.29, 0.84; P = 0.01). There was no significant effect on hematoma (OR = 0.21; 95% CI: 0.03, 1.27; P = 0.09), seroma (OR = 0.26; 95% CI: 0.05, 1.28; P = 0.1) and LOS (MD = -0.16, 95% CI: -0.83, 0.51; P = 0.64).ConclusionThe use of NPWT following stoma reversal in colorectal surgery reduced the incidence of SSI. However, this conclusion needs to be interpreted with caution, and further studies should be conducted to confirm in higher-quality RCTs.
C1 [Zhu, Junjia; Sun, Qi; Xu, Wenlong; Feng, Qiang; Zhao, Zhenguo; Li, Sen] Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, Jiangyin, Peoples R China.
   [Geng, Jun] Nantong Univ, Jiangyin Peoples Hosp, Dept Anesthesiol, Jiangyin, Peoples R China.
   [Zhao, Zhenguo; Li, Sen] Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, 3 Yingrui Rd, Nantong 214400, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Zhao, ZG; Li, S (通讯作者)，Nantong Univ, Jiangyin Peoples Hosp, Dept Gen Surg, 3 Yingrui Rd, Nantong 214400, Jiangsu, Peoples R China.
EM 54yonggan@163.com; jyrmyyls@163.com
OI Zhao, Zhenguo/0000-0003-1230-3116
FU Youth Research Project Fund of Wuxi Municipal Health Commission; Wuxi
   Taihu Lake talent plan' medical and health high level talent project
   [NO2020103]; Wuxi precision medicine project [J202009]
FX This study was supported by Youth Research Project Fund of Wuxi
   Municipal Health Commission (NO.Q201949); Wuxi Taihu Lake talent plan'
   medical and health high level talent project, NO2020103; Wuxi precision
   medicine project, J202009.
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   Webster J, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub4
   Wierdak M, 2021, TECH COLOPROCTOL, V25, P185, DOI 10.1007/s10151-020-02372-w
   Yane Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05016-1
NR 46
TC 9
Z9 10
U1 1
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0894-1939
EI 1521-0553
J9 J INVEST SURG
JI J. Invest. Surg.
PD DEC 31
PY 2023
VL 36
IS 1
DI 10.1080/08941939.2023.2175079
EA JAN 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA N3O1M
UT WOS:000924672700001
PM 36740239
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hudson, DA
   Adams, KG
   Van Huyssteen, A
   Martin, R
   Huddleston, EM
AF Hudson, Donald A.
   Adams, Kevin G.
   Van Huyssteen, Adriaan
   Martin, Robin
   Huddleston, Elizabeth M.
TI Simplified negative pressure wound therapy: clinical evaluation of an
   ultraportable, no-canister system
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Closed surgical incision; Negative pressure wound therapy; Portable;
   Postoperative care; Wound healing
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CLOSED INCISION
   MANAGEMENT; SURGICAL INCISIONS; DEHISCENCE; FRACTURES; SURGERY; DEVICE;
   MODEL
AB The aim of this study was to evaluate a prototype negative pressure wound therapy (NPWT) system that has been developed to simplify NPWT for wounds at the lower end of the acuity scale. The new device has a single preset pressure of -80mmHg, is single use and operates without an exudate canister. The disposable NPWT system (PICO) was tested in a prospective, non-comparative, multicentre clinical trial to assess device functionality and clinical acceptance. Twenty patients were recruited for a maximum treatment period of 14days. The NPWT devices were fitted with data log chips to enable longitudinal assessment of negative pressure and leak rates during therapy. Sixteen (80%) patients had closed surgical wounds, two (10%) patients had traumatic wounds and two (10%) patients received meshed split thickness skin grafts. The mean study duration was 107days (range: 5-14days) and the mean dressing wear time per individual patient was 46days (range: 2-11). Fifty-five percent of wounds had closed by the end of the 14-day study or earlier, with a further 40% of wounds progressing to closure. Real-time pressure monitoring showed continuous delivery of NPWT. Three cases are discussed representing different wound locations and different patient factors that can increase the risk of post-surgical complications. Clinical studies of the disposable NPWT system confirmed the ability of the simplified single-use device to function consistently over the expected wear time. The anticipated reduced costs, ease of use and increased mobility of patients using this system may enable NPWT benefits to be available to a greater proportion of patients.
C1 [Hudson, Donald A.; Adams, Kevin G.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Hudson, Donald A.; Adams, Kevin G.] Univ Cape Town, ZA-7925 Cape Town, South Africa.
   [Van Huyssteen, Adriaan] Panorama Medi Clin, Orthopaed Hip & Knee Surg, Cape Town, South Africa.
   [Martin, Robin; Huddleston, Elizabeth M.] Smith & Nephew Med Ltd, Adv Wound Management Div, Kingston Upon Hull, N Humberside, England.
C3 University of Cape Town; University of Cape Town; Smith & Nephew
RP Huddleston, EM (通讯作者)，Smith & Nephew Med Ltd, Adv Wound Management Div, POB 81 101 Hessle Rd, Kingston Upon Hull, N Humberside, England.
EM elizabeth.huddleston@smith-nephew.com
OI Martin, Robin/0000-0002-9314-0437
FU Smith Nephew Ltd.
FX This work was funded by Smith & Nephew Ltd. EH and RM are employees of
   Smith & Nephew. The authors would like to thank Ben Askem (Smith &
   Nephew Hull) for providing data analysis and evaluation of the device
   data loggers and 3 Degree Clinical Research Organisation in South Africa
   for clinical trial monitoring services.
CR Abbas SM, 2009, ANZ J SURG, V79, P247, DOI 10.1111/j.1445-2197.2009.04854.x
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NR 28
TC 55
Z9 61
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2015
VL 12
IS 2
BP 195
EP 201
DI 10.1111/iwj.12080
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CE2EI
UT WOS:000351626400014
PM 23647737
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Chattinnakorn, S
   Suwajo, P
   Meevassana, J
   Nilprapha, K
   Pungrasmi, P
   Promniyom, P
   Iamphongsai, S
   Jindarak, S
   Angspatt, A
AF Chattinnakorn, Suphot
   Suwajo, Poonpissamai
   Meevassana, Jiraroch
   Nilprapha, Kasama
   Pungrasmi, Pornthep
   Promniyom, Pasu
   Iamphongsai, Seree
   Jindarak, Sirachai
   Angspatt, Apichai
TI The Effect of Cold Water on Pain Evaluation During Negative Pressure
   Wound Therapy Dressing Changes: A Prospective, Randomized Controlled
   Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative pressure wound therapy; NPWT; pain; wound dressing
ID VACUUM-ASSISTED CLOSURE; SUBSTANCE-P; INJURY; LEVEL
AB Negative pressure wound therapy (NPWT) is a technique using vacuum dressing to promote wound healing in complicated wound. However, for many patients, the application and removal of the NPWT is source of procedural pain. The authors hypothesized that administering cold sterile water into the NPWT sponge would decrease pain during dressing changes. A prospective randomized controlled study was conducted on 27 patients who were undergoing 81 NPWT wound dressing changes (n = 81) at a single institution between October 2016 and September 2017. Each patient had 3 NPWT dressing changes. Cold sterile water (5.74 degrees C), room temperature sterile water (26.89 degrees C), and nothing were randomized and administered in the NPWT tubing into the sponge 10 minutes before changing the dressing in each and every procedure. Pain scores were assessed using a 0 to 10 numeric pain scale. Patients administered with cold water reported less pain than those administered with room temperature sterile water during the dressing change (4 vs 5.67;P< .003), and much less pain than those with nothing instilled before dressing change (4 vs 6.59;P< .001). There is no statistically significant difference in pain score between using the room temperature sterile water group and the control group that instilled nothing (5.67 vs 6.59;P= .065). This study has shown that cold water administered through the suction tubing before the dressing change had a better reduction in pain score than using room temperature sterile water and the control group.
C1 [Chattinnakorn, Suphot; Suwajo, Poonpissamai; Meevassana, Jiraroch; Nilprapha, Kasama; Pungrasmi, Pornthep; Promniyom, Pasu; Iamphongsai, Seree; Jindarak, Sirachai; Angspatt, Apichai] Chulalongkorn Univ, Bangkok, Thailand.
C3 Chulalongkorn University
RP Angspatt, A (通讯作者)，Chulalongkorn Univ, Div Plast & Reconstruct Surg, Dept Surg, Fac Med, Rama 4 Rd, Bangkok 10330, Thailand.
EM aangspatt@hotmail.com
RI ; Suwajo, Poonpissamai/GOK-1291-2022
OI meevassana, jiraroch/0000-0001-8915-2999; 
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NR 27
TC 3
Z9 3
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 432
EP 435
AR 1534734620950177
DI 10.1177/1534734620950177
EA AUG 2020
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000567358800001
PM 32865057
DA 2026-07-24
ER

PT J
AU Kwa, KAA
   Krijnen, P
   Bernards, AT
   Schipper, IB
   Meij-de Vries, A
   Breederveld, RS
AF Kwa, Kelly Aranka Ayli
   Krijnen, Pieta
   Bernards, Alexandra T.
   Schipper, Inger B.
   Meij-de Vries, Annebeth
   Breederveld, Roelf S.
TI Bacterial Species and Load Increase During Negative Pressure Wound
   Therapy: A Prospective Cohort Study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE bacteria; infection; negative pressure wound therapy; NPWT;
   Staphylococcus aureus
ID VACUUM-ASSISTED CLOSURE; CARE SETTINGS; INFECTIONS; MANAGEMENT; INJURY;
   GROIN
AB Introduction. The course of both the bacterial species and load and the incidence of infection during negative pressure wound therapy (NPWT) are unclear, with published studies presenting contradicting results. Objective. The aim of the study is to assess the changes in both bacterial species and load, as well as the incidence of infection, before and after NPWT in a patient population with a variety of wounds. Methods. Surgical patients 18 years of age or older who needed NPWT were included in this multicenter, prospective cohort study. A wound swab culture was taken before NPWT and either immediately following NPWT or 6 weeks of follow-up. The change of bacterial species, bacterial load, and rate of infection were determined before and after the start of NPWT. Results. In total, 104 patients were analyzed. The number of positive cultures increased from pre- to post-NPWT. The most cultured pathogenic bacterium was Staphylococcus aureus. The bacterial load was moderately higher at the end of NPWT than at the start (P < .0001). It was noted that 2 swabs contained multidrug-resistant bacteria, 1 pre-NPWT and 1 post-NPWT. Prior to NPWT, 26 patients had a wound infection, 5 of which had a persisting infection at the end of the study. Post-NPWT, 14 patients developed a wound infection. Conclusions. The number of S aureus strains and overall bacterial load increased during NPWT, and the incidence of infection remained the same. Further studies should be conducted to determine whether the increase in bacterial load influences other wound outcome parameters.
C1 [Kwa, Kelly Aranka Ayli; Krijnen, Pieta; Schipper, Inger B.; Breederveld, Roelf S.] Leiden Univ, Med Ctr, Dept Trauma Surg, K6-50,POB 9600, NL-2300 RC Leiden, Netherlands.
   [Kwa, Kelly Aranka Ayli; Meij-de Vries, Annebeth; Breederveld, Roelf S.] Red Cross Hosp, Bum Ctr Beverwijk, Beverwijk, Netherlands.
   [Bernards, Alexandra T.] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC)
RP Krijnen, P (通讯作者)，Leiden Univ, Med Ctr, Dept Trauma Surg, K6-50,POB 9600, NL-2300 RC Leiden, Netherlands.
EM p.krijnen@lumc.nl
RI Inger, Schipper/ABE-7796-2021
OI Inger, Schipper/0000-0001-9952-3079; Krijnen, Pieta/0000-0002-7154-9514
CR Alcala-Marquez C, 2018, CLIN SPINE SURG, V31, P351, DOI 10.1097/BSD.0000000000000668
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   Wang GQ, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/9496183
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   Yusuf E, 2013, WOUND REPAIR REGEN, V21, P677, DOI 10.1111/wrr.12088
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NR 43
TC 6
Z9 7
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2020
VL 32
IS 3
BP 74
EP 80
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA QJ6MA
UT WOS:000619801500004
PM 32163041
DA 2026-07-24
ER

PT J
AU Raju, A
   Ooi, A
   Ong, YS
   Tan, BK
AF Raju, Ashvin
   Ooi, Adrian
   Ong, Yee Siang
   Tan, Bien Keem
TI Traumatic Lower Limb Injury and Microsurgical Free Flap Reconstruction
   with the Use of Negative Pressure Wound Therapy: Is Timing Crucial?
SO JOURNAL OF RECONSTRUCTIVE MICROSURGERY
LA English
DT Article; Proceedings Paper
CT 7th Biennial Meeting of the World-Society-of-Reconstructive-Microsurgery
   (WSRM)
CY JUL 11-14, 2013
CL Chicago, IL
SP World Soc Reconstruct Microsurgery
DE negative pressure wound therapy; lower limb trauma; free flap
ID VACUUM-ASSISTED CLOSURE; LOWER-EXTREMITY TRAUMA; SEVERE OPEN FRACTURES;
   SOFT-TISSUE COVERAGE; MANAGEMENT; OUTCOMES; DEFECTS; DISTAL; LEG
AB Background The timing of microsurgical free flap reconstruction for traumatic lower limb injury has been described as being optimal if conducted within the early period following injury, as higher rates of infection and flap loss were reported in the subsequent time period. However, for various reasons, reconstruction of these defects may be delayed. The aim of this article is to show that adequate debridement, negative pressure wound dressing, and sound reconstructive principles has led to increased free flap success rates regardless of the period between injury and reconstruction.
   Patients and Methods A 10-year retrospective single-center analysis of 50 traumatic lower limb cases from 2002 to 2012 was conducted. All patients had microsurgical free flap reconstruction after a period of negative pressure wound therapy (NPWT). Patient factors and reconstructive methods were analyzed and outcomes were compared.
   Results Mean interval between admission and free flap coverage was 17.5 days, and patients underwent NPWT for an average of 12 days (range, 1-35). Approximately 8% of patients had postoperative infections. Overall free flap success rate was 96%. Approximately 90% of patients were able to return to their premorbid footwear, with 96% able to mobilize independently approaching the end of their follow-up period.
   Conclusion Our study shows that traumatic lower limb reconstruction in the delayed period is no longer associated with high rates of flap failure. Improvements in microsurgery and the advent of NPWT have made timing no longer crucial in free flap coverage of traumatic lower limb injuries.
C1 [Raju, Ashvin] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore.
   [Ooi, Adrian; Ong, Yee Siang; Tan, Bien Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
C3 National University of Singapore; Singapore General Hospital
RP Ooi, A (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM dradrianooi@gmail.com
RI Ooi, Adrian/AAJ-8480-2021
OI Ooi, Adrian/0000-0001-7983-3635
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NR 24
TC 32
Z9 36
U1 0
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0743-684X
EI 1098-8947
J9 J RECONSTR MICROSURG
JI J. Reconstr. Microsurg.
PD JUL
PY 2014
VL 30
IS 6
BP 427
EP 430
DI 10.1055/s-0034-1371510
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA AK8OD
UT WOS:000338686300011
PM 24752744
DA 2026-07-24
ER

PT J
AU Dowsett, C
   Davis, L
   Henderson, V
   Searle, R
AF Dowsett, Caroline
   Davis, Lynn
   Henderson, Valerie
   Searle, Richard
TI The economic benefits of negative pressure wound therapy in
   community-based wound care in the NHS
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Community; Database; Health economics; Negative pressure wound therapy;
   Wound care
ID RANDOMIZED CONTROLLED-TRIAL; VACUUM-ASSISTED CLOSURE; ULCERS;
   MULTICENTER; COST
AB The human and economic costs of wounds are of major concern within today's National Health Service. Advances in wound care technology have been shown to be beneficial both in healing and in relation to patient quality of life. Negative pressure has often been associated with high-cost care and restricted to use in the secondary care setting. There is growing use of negative pressure within the community, and this has the potential to benefit the patient and the service by providing quality care in the patient's home setting. Three community sites were chosen to monitor their use of negative pressure wound therapy (NPWT) over a period of 2 years, and this paper presents some of the key findings of this work. The data generated has been used to help target resources and prevent misuse of therapy. Cost per patient episode has been calculated, and this can be compared to similar costs in secondary care, showing significant savings if patients are discharged earlier from secondary care. There is also an increased demand for more patients with complex wounds to be cared for in the community, and in the future, it is likely that community initiated NPWT may become more common. Early analysis of the data showed that the average cost of dressing complex wounds would be significantly less than using traditional dressings, where increased nursing visits could increase costs. There is a compelling argument for more negative pressure to be used and initiated in the community, based not only on improved quality of life for patients but also on the economic benefits of the therapy.
C1 [Searle, Richard] Smith & Nephew Healthcare, Kingston Upon Hull, N Humberside, England.
   [Dowsett, Caroline] E London NHS Fdn Trust, London, England.
C3 Smith & Nephew
RP Searle, R (通讯作者)，Smith & Nephew Healthcare, Kingston Upon Hull, N Humberside, England.
EM Richard.searle@smith-nephew.com
CR [Anonymous], 2008, BEST PRACT STAT GAUZ
   [Anonymous], TRANSF COMM SERV
   [Anonymous], 2010, EQ EXC LIB NHS
   [Anonymous], 2010, NHS OUTC FRAM 2011 1
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   Department of Health, 2011, UK DRUG TAR MAY 2011
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   NHS, NAT REF COSTS 2008 9, P2008
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   Vowden K, 2009, J Wound Care, V18, P93
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 17
TC 38
Z9 44
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2012
VL 9
IS 5
BP 544
EP 552
DI 10.1111/j.1742-481X.2011.00913.x
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 010AG
UT WOS:000309066200011
PM 22321132
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Janssen, AHJ
   Wegdam, JA
   Reilingh, TSD
   Vermeulen, H
   Eskes, AM
AF Janssen, Alexandra H. J.
   Wegdam, Johannes A.
   Reilingh, Tammo S. de Vries
   Vermeulen, Hester
   Eskes, Anne M.
TI Which determinants are considered to be important for adherence to
   Negative Pressure Wound Therapy: A multimethods study
SO JOURNAL OF TISSUE VIABILITY
LA English
DT Article
DE Adherence; Shared decision making; Multimethod research; Negative
   pressure wound therapy; Quality of life
ID VACUUM-ASSISTED CLOSURE; LIFE-STYLE INTERVENTION; PATIENT; MANAGEMENT;
   OBESITY; HEALTH; CARE; NONRESPONSE; PREDICTORS; GUIDELINES
AB Aim: To explore the extent of patients that choose to cease Negative Pressure Wound Therapy (NPWT) prematurely in a clinical setting, and to explore the determinants of nonadherence.
   Method: This study exists out of: (1) a retrospective study to assess the number of patients who ceased NPWT prematurely; (2) a narrative review (NR) to identify determinants of nonadherence; and (3) a survey among wound care specialists to explore specific determinants of nonadherence to NPWT.
   Results: (1) Based on the retrospective study, 20% ceased NPWT prematurely because of experienced limitations in daily activities.
   (2) Based on 22 studies, 23 determinants that might influence nonadherence were identified and added as questions in the survey.
   (3) Twenty-two percent (n = 136) wound care specialists completed the survey. Confidence with the healthcare team, consistency in therapy advices, coping with pain, former negative experiences with NPWT, a normal activity pattern, social support from family or friends, and support from the healthcare team were identified as highly relevant determinants of nonadherence to NPWT. Only religion scored distinctively lower.
   Conclusion: This study is a first step in exploring the determinants of nonadherence to NPWT. In 20% NPWT was prematurely ceased at the request of the patient, this means that this therapy may have not been the best choice of therapy for this particular patient. The identification of potential determinants of nonadherence may help healthcare professionals in their dialogue with patients. The next step should be a prognostic study to assess which determinants best predict adherence to NPWT.
C1 [Janssen, Alexandra H. J.; Wegdam, Johannes A.; Reilingh, Tammo S. de Vries] Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
   [Vermeulen, Hester] Radboud Univ Nijmegen, Sci Inst Qual Healthcare IQ Healthcare, Nijmegen, Netherlands.
   [Eskes, Anne M.] Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands.
   [Eskes, Anne M.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
   [Eskes, Anne M.] Griffith Univ, Sch Nursing & Midwifery, Gold Coast, Australia.
   [Janssen, Alexandra H. J.] Laag Strijp 9, NL-5735 PD Aarle Rixtel, Netherlands.
C3 Radboud University Nijmegen; University of Amsterdam; Griffith
   University; Menzies Health Institute Queensland; Griffith University
RP Janssen, AHJ (通讯作者)，Elkerliek Hosp, Dept Surg, Wesselmanlaan 25, NL-5707 HA Helmond, Netherlands.
EM sjanssen@elkerliek.nl
RI ; Eskes, Anne/HKV-3276-2023; Vermeulen, Hester/P-5739-2016
OI Eskes, Anne Maria/0000-0003-1605-0195; Janssen,
   Alexana/0000-0003-1816-0814; wegdam, johannes/0000-0002-3287-0233
CR [Anonymous], BR J NURS
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NR 50
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0965-206X
EI 1876-4746
J9 J TISSUE VIABILITY
JI J. Viab.
PD MAY
PY 2021
VL 30
IS 2
BP 250
EP 255
DI 10.1016/j.jtv.2021.01.009
EA APR 2021
PG 6
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA RU2PP
UT WOS:000644992700015
PM 33581961
DA 2026-07-24
ER

PT J
AU Murphy, PB
   Knowles, S
   Chadi, SA
   Vogt, K
   Brackstone, M
   Van Koughnett, JA
   Ott, MC
AF Murphy, Patrick B.
   Knowles, Sarah
   Chadi, Sami A.
   Vogt, Kelly
   Brackstone, Muriel
   Van Koughnett, Julie Ann
   Ott, Michael C.
TI Negative Pressure Wound Therapy Use to Decrease Surgical Nosocomial
   Events in Colorectal Resections (NEPTUNE) A Randomized Controlled
   Trial
SO ANNALS OF SURGERY
LA English
DT Article
DE colectomy; colon; negative pressure wound therapy; NPWT; SSI; surgical
   site infection
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; METAANALYSIS; PREVENTION;
   SURGERY; LAPAROTOMY; INCISIONS; DISEASE; SYSTEM
AB Objective: Determine if negative pressure wound therapy (NPWT) reduces surgical site infection (SSI) in primarily closed incision after open and laparoscopic-converted colorectal surgery.
   Background: SSIs after colorectal surgery are a common cause of morbidity. The prophylactic effect of NPWT has not been established. We undertook this study to evaluate if, among patients undergoing open colorectal resection, NPWT, as compared with standard postoperative dressings, is associated with a reduction in the rate of postoperative SSI.
   Methods: In a randomized, controlled trial, 300 patients undergoing elective open colorectal surgery were assigned to receive prophylactic NPWT or standard gauze dressing. The primary end-point was 30-day SSI, as assessed by wound care experts blinded to treatment arm. Secondary outcomes included length of stay. Statistical analysis was performed on an intention-to-treat basis. A priori subgroup analysis was planned for patients who received a stoma at the time of initial operation.
   Results: The incidence of SSI at 30-days postoperatively was no different between experimental and control groups (32% vs 34% respectively, P = 0.68). Length of stay was also no different at a median of 7 days (IQR 5) for both groups. Among patients receiving a stoma, there was also no difference in SSI between the experimental and control groups (38% vs 33% respectively, P = 0.66).
   Conclusions: Prophylactic use of NPWT on primarily closed incisions after open colorectal surgery was not associated with a decrease in SSI rate when compared with standard gauze dressing.
C1 [Murphy, Patrick B.; Knowles, Sarah; Chadi, Sami A.; Vogt, Kelly; Brackstone, Muriel; Van Koughnett, Julie Ann; Ott, Michael C.] Western Univ, Schulich Sch Med & Dent, Dept Surg, Div Gen Surg, London, ON, Canada.
C3 Western University (University of Western Ontario)
RP Murphy, PB (通讯作者)，Victoria Hosp, Div Gen Surg, London Hlth Sci Ctr, Room E2-214,800 Commissioners Rd East, London, ON N6A 5W9, Canada.
EM pbatesmurphy@gmail.com
RI Murphy, Patrick/T-5337-2019; Chadi, Sami/DWM-5165-2022
OI Ott, Michael/0000-0002-0816-7089
FU Kinetic Concepts Inc. (San Antonio, TX)
FX The study was funded by an industry grant from Kinetic Concepts Inc.
   (San Antonio, TX) in the amount of $ 87 000. The devices were also
   provided free of charge.
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NR 28
TC 64
Z9 68
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUL
PY 2019
VL 270
IS 1
BP 38
EP 42
DI 10.1097/SLA.0000000000003111
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA IQ4PQ
UT WOS:000480733100021
PM 30499799
DA 2026-07-24
ER

PT J
AU Zeybek, B
   Li, S
   Fernandez, JW
   Stapley, S
   Silberschmidt, VV
   Liu, Y
AF Zeybek, B.
   Li, S.
   Fernandez, J. W.
   Stapley, S.
   Silberschmidt, V. V.
   Liu, Y.
TI Computational modelling of wounded tissue subject to negative pressure
   wound therapy following trans-femoral amputation
SO BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
LA English
DT Article
DE Finite-element analysis; Biomechanics; Negative pressure wound therapy;
   Tissue oxygenation
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; EVIDENCE-BASED
   RECOMMENDATIONS; OXYGEN-TRANSPORT; INTERNATIONAL CONSENSUS;
   POLYURETHANE-FOAM; SKELETAL-MUSCLE; LASER-DOPPLER; MICROCIRCULATION;
   MANAGEMENT
AB Proof-of-concept computational models were developed and applied as tools to gain insights into biomechanical interactions and variations of oxygen gradients of wounded tissue subject to negative pressure wound therapy (NPWT), following trans-femoral amputation. A macro-scale finite-element model of a lower limb was first developed based on computed tomography data, and distributions of maximum and minimum principal stress values we calculated for a region of interest (ROI). Then, the obtained results were applied iteratively as new sets of boundary conditions for a specific spatial position in a capillary sub-model. Data from coupled capillary stress and mass- diffusion sub-models were transferred to the macro-scale model to map the spatial changes of tissue oxygen gradients in the ROI. The -70 mmHg NPWT resulted in a dramatic change of a wound surface area and the greatest relative contraction was observed at -150 mmHg. Tissue lateral to the depth of the wound cavity revealed homogenous patterns of decrease in oxygenation area and the extent of such decrease was dependent on the distance from the wound surface. However, tissue lateral to the width of the wound demonstrated heterogeneous patterns of change, as evidenced by both gradual increase and decrease in the oxygenation area. The multiscale models developed in the current study showed a significant influence of NPWT on both macro-deformations and changes of tissue oxygenation. The patterns of changes depended on the depth of the tissue, the geometry of the wound, and also the location of tissue plane.
C1 [Zeybek, B.; Li, S.; Silberschmidt, V. V.; Liu, Y.] Loughborough Univ Technol, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.
   [Fernandez, J. W.] Auckland Univ, Auckland Bioengn Inst, Auckland, New Zealand.
   [Fernandez, J. W.] Auckland Univ, Dept Engn Sci, Auckland, New Zealand.
   [Stapley, S.] Royal Ctr Def Med, ICT Ctr, Birmingham, W Midlands, England.
   [Stapley, S.] Queen Alexandra Hosp, Dept Trauma & Orthoped, Portsmuth, England.
   [Liu, Y.] Loughborough Univ Technol, Ctr Biol Engn, Loughborough, Leics, England.
C3 Loughborough University; University of Auckland; University of Auckland;
   Royal Centre for Defence Medicine; Portsmouth Hospitals NHS Trust; Queen
   Alexandra Hospital; Loughborough University
RP Liu, Y (通讯作者)，Loughborough Univ Technol, Wolfson Sch Mech Elect & Mfg Engn, Loughborough, Leics, England.; Liu, Y (通讯作者)，Loughborough Univ Technol, Ctr Biol Engn, Loughborough, Leics, England.
EM Y.liu3@lboro.ac.uk
RI ; Li, Simin/A-8040-2015; Liu, Yang/A-4046-2011; Silberschmidt, Vadim
   V/G-7113-2011
OI Zeybek Saglam, Begum/0000-0001-6789-043X; Silberschmidt, Vadim
   V/0000-0003-3338-3311
FU Marie Sklodowska-Curie Research and Innovation Staff Exchange programme
   [FP7-PEOPLE-2012-IRSES, 318553]; Loughborough University, Wolfson School
   of Mechanical, Electrical and Manufacturing Engineering
FX BZ's exchange activity with Auckland University was supported by the
   Marie Sklodowska-Curie Research and Innovation Staff Exchange programme
   (FP7-PEOPLE-2012-IRSES, 318553), and BZ's PhD study was partially funded
   by Loughborough University, Wolfson School of Mechanical, Electrical and
   Manufacturing Engineering.
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NR 54
TC 5
Z9 8
U1 0
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1617-7959
EI 1617-7940
J9 BIOMECH MODEL MECHAN
JI Biomech. Model. Mechanobiol.
PD DEC
PY 2017
VL 16
IS 6
BP 1819
EP 1832
DI 10.1007/s10237-017-0921-7
PG 14
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA FL7SK
UT WOS:000414450200001
PM 28553679
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Lee, AJ
   Sheppard, CE
   Kent, WDT
   Mewhort, H
   Sikdar, KC
   Fedak, PWM
AF Lee, Arthur J.
   Sheppard, Christina E.
   Kent, William D. T.
   Mewhort, Holly
   Sikdar, Khokan C.
   Fedak, Paul W. M.
TI Safety and efficacy of prophylactic negative pressure wound therapy
   following open saphenous vein harvest in cardiac surgery: a feasibility
   study
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Wound healing; Cardiac surgery
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; INFECTIONS; INCISIONS
AB OBJECTIVES: Surgical site complications following great saphenous vein (GSV) harvest presents a significant risk of morbidity. Negative pressure wound therapy (NPWT) has shown promise in the treatment and prophylaxis of open wounds and surgical incisions but has not been studied following GSV harvest. We performed a feasibility study examining the use of NPWT following GSV harvest for coronary bypass surgery.
   METHODS: Sixty-four patients were recruited in this single-centre, single-blind, randomized controlled trial. The primary endpoint assessed feasibility by examining rates of device complication and malfunction. Secondary endpoints included rates of surgical site infection, lower leg complications, discharge date, and quality of life at discharge and 6 weeks. NPWT was delivered using the Prevena NPWT device.
   RESULTS: There were no complications associated with NPWT which required intervention aside from discontinuation. NPWT was tolerated in 91% (30/33) of patients for the duration of treatment with an average of 4.8 days (+/- 1.45 days). Device malfunction which required discontinuation was 6% (2/33) and involved a malfunctioning pressure sensor and did not affect patient care or present safety concerns. One patient had allergic contact dermatitis to the adhesive and had the device removed. NPWT patients had an earlier date of discharge (6 vs 10 days, P = 0.008), increased ability for self-care (P = 0.0234) and quality of life (P = 0.039) at initial assessment, and increased mobility at initial and follow-up assessment (P = 0.0117 and 0.0123).
   CONCLUSIONS: The use of NPWT following GSV harvest is safe, well tolerated and improves postoperative recovery with prolonged impact on mobility at 6 weeks.
C1 [Lee, Arthur J.] Univ British Columbia, Div Cardiac Surg, Dept Surg, Vancouver, BC, Canada.
   [Sheppard, Christina E.; Kent, William D. T.; Mewhort, Holly; Sikdar, Khokan C.; Fedak, Paul W. M.] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Cardiac Sci, Calgary, AB, Canada.
C3 University of British Columbia; University of Calgary; Libin
   Cardiovascular Institute Of Alberta
RP Fedak, PWM (通讯作者)，Dept Cardiac Sci, Div Cardiac Surg, C880,1403-29 St NW, Calgary, AB T2N 2T9, Canada.
EM paul.fedak@gmail.com
RI ; Kent, William/AAA-3834-2020
OI Mewhort, Holly/0000-0002-3503-6076; Fedak, Paul/0000-0003-0658-9381
FU KCI USA Incorporated, an Acelity Company
FX This work was supported by KCI USA Incorporated, an Acelity Company.
CR [Anonymous], 2004, Zhongguo Linchuang Kangfu
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NR 23
TC 29
Z9 29
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD MAR
PY 2017
VL 24
IS 3
BP 324
EP 328
DI 10.1093/icvts/ivw400
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA EV9KV
UT WOS:000402105800002
PM 28025309
OA Bronze
DA 2026-07-24
ER

PT J
AU Coutin, JV
   Lanz, OI
   Magnin-Bissel, GC
   Ehrich, MF
   Miller, EI
   Werre, SR
   Riegel, TO
AF Coutin, Julia V.
   Lanz, Otto I.
   Magnin-Bissel, Geraldine C.
   Ehrich, Marion F.
   Miller, Emily I.
   Werre, Stephen R.
   Riegel, Thomas O.
TI Cefazolin Concentration in Surgically Created Wounds Treated With
   Negative Pressure Wound Therapy Compared to Surgically Created Wounds
   Treated With Nonadherent Wound Dressings
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TANDEM MASS-SPECTROMETRY; MICROVASCULAR
   BLOOD-FLOW; BETA-LACTAM ANTIBIOTICS; ENDOTHELIAL GROWTH-FACTOR;
   SOLID-PHASE EXTRACTION; ANTIBACTERIAL ACTIVITY; LIQUID-CHROMATOGRAPHY;
   PROTEIN-BINDING; CYTOKINE LEVELS
AB ObjectiveTo compare cefazolin concentrations in biopsied tissue samples collected from surgically created wounds treated with negative pressure wound therapy to those collected from surgically created wounds treated with nonadherent dressings.
   Study DesignProspective, controlled, experimental study.
   AnimalsAdult female spayed Beagles (n=12).
   MethodsFull thickness cutaneous wounds were created on each antebrachium (n=24). Immediately after surgery, cefazolin (22mg/kg intravenously [IV]) was administered to each dog and continued every 8hours during the study. The right wound was randomly assigned to group I or group II whereas the wound on the contralateral antebrachium was assigned to the other group. Group I wounds were treated with negative pressure wound therapy (NPWT) and group II wounds were treated with nonadherent dressings for 3 days. Dressings were changed and tissue biopsies obtained from wound beds at 24hours intervals for both groups. Cefazolin wound tissue and plasma concentrations were measured by liquid chromatography mass spectrometry (LC-MS/MS). Blood samples for measuring plasma cefazolin concentrations were collected before biopsy sampling. At the time of surgery and at each subsequent bandage change, wound beds were swabbed and submitted for aerobic and anaerobic culture.
   ResultsAfter initiating cefazolin treatment, wound tissue antibiotic concentrations between treatment groups were not significantly different at any sampling time. Similarly, after initiating cefazolin treatment, plasma cefazolin concentrations were not significantly different at any sampling time for individual dogs.
   ConclusionsUsing a canine experimental model, NPWT treatment of surgically created wounds does not statistically impact cefazolin tissue concentrations when compared with conventional nonadherent bandage therapy.
C1 [Coutin, Julia V.; Lanz, Otto I.; Miller, Emily I.; Riegel, Thomas O.] Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Phase 2 Duckpond Dr, Blacksburg, VA 24061 USA.
   [Magnin-Bissel, Geraldine C.] Virginia Maryland Reg Coll Vet Med, Dept Res & Grad Studies, Blacksburg, VA 24061 USA.
   [Ehrich, Marion F.; Werre, Stephen R.] Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA.
RP Lanz, OI (通讯作者)，Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Phase 2 Duckpond Dr, Blacksburg, VA 24061 USA.
EM olanz@vt.edu
OI Ehrich, Marion/0000-0002-5466-4203; Magnin,
   Geraldine/0000-0001-9061-7263
FU Virginia-Maryland Regional College of Veterinary Medicine, Veterinary
   Memorial Fund
FX Funded in part by the Virginia-Maryland Regional College of Veterinary
   Medicine, Veterinary Memorial Fund.
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NR 51
TC 13
Z9 19
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JAN
PY 2015
VL 44
IS 1
BP 9
EP 16
DI 10.1111/j.1532-950X.2014.12218.x
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AX5JU
UT WOS:000346963000003
PM 24962470
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Milleret, V
   Bittermann, AG
   Mayer, D
   Hall, H
AF Milleret, Vincent
   Bittermann, Anne Greet
   Mayer, Dieter
   Hall, Heike
TI Analysis of Effective Interconnectivity of DegraPol-foams Designed for
   Negative Pressure Wound Therapy
SO MATERIALS
LA English
DT Article
DE Degrapol (R); polymer foams; pore interconnectivity; Negative Pressure
   Wound Therapy (NPWT)
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; MEMBRANES;
   COPOLYESTERS; HYDROGEL; GRAFTS
AB Many wounds heal slowly and are difficult to manage. Therefore Negative Pressure Wound Therapy (NPWT) was developed where polymer foams are applied and a defined negative pressure removes wound fluid, reduces bacterial burden and increases the formation of granulation tissue. Although NPWT is used successfully, its mechanisms are not well understood. In particular, different NPWT dressings were never compared. Here a poly-ester urethane Degrapol (R) (DP)-foam was produced and compared with commercially available dressings (polyurethane-based and polyvinyl-alcohol-based) in terms of apparent pore sizes, swelling and effective interconnectivity of foam pores. DP-foams contain relatively small interconnected pores; PU-foams showed large pore size and interconnectivity; whereas PVA-foams displayed heterogeneous and poorly interconnected pores. PVA-foams swelled by 40 %, whereas DP- and PU-foams remained almost without swelling. Effective interconnectivity was investigated by submitting fluorescent beads of 3, 20 and 45 mu m diameter through the foams. DP- and PU-foams removed 70-90 % of all beads within 4 h, independent of the bead diameter or bead pre-adsorption with serum albumin. For PVA-foams albumin pre-adsorbed beads circulated longer, where 20 % of 3 mu m and 10 % of 20 mu m diameter beads circulated after 96 h. The studies indicate that efficient bead perfusion does not only depend on pore size and swelling capacity, but effective interconnectivity might also depend on chemical composition of the foam itself. In addition due to the efficient sieve-effect of the foams uptake of wound components in vivo might occur only for short time suggesting other mechanisms being decisive for success of NPWT.
C1 [Milleret, Vincent; Hall, Heike] Swiss Fed Inst Technol, Dept Mat, Zurich, Switzerland.
   [Bittermann, Anne Greet] Univ Zurich, Ctr Microscopy & Imaging Anal, ZMB, CH-8006 Zurich, Switzerland.
   [Mayer, Dieter] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Zurich; University of Zurich; University Zurich Hospital
RP Hall, H (通讯作者)，Swiss Fed Inst Technol, Dept Mat, Zurich, Switzerland.
EM vincent.milleret@mat.ethz.ch; agb@access.unizh.ch; dieter.mayer@usz.ch;
   heike.hall@mat.ethz.ch
RI Mayer, Dieter/E-7617-2011
FU ab-medica, Lainate, Italy
FX The authors would like to thank D-MATL ETH-Zurich tool shop for
   excellent technical help in production of the flow device and ab-medica,
   Lainate, Italy for a fellowship for V. M.
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NR 41
TC 8
Z9 10
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1996-1944
J9 MATERIALS
JI Materials
PD MAR
PY 2009
VL 2
IS 1
BP 292
EP 306
DI 10.3390/ma2010292
PG 15
WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy &
   Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering;
   Physics
GA V20KS
UT WOS:000208139500014
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Mushin, OP
   Bogue, JT
   Esquenazi, MD
   Toscano, N
   Bell, DE
AF Mushin, Oren P.
   Bogue, Jarrod T.
   Esquenazi, Mica D.
   Toscano, Nicole
   Bell, Derek E.
TI Use of a home vacuum-assisted closure device in the burn population is
   both cost-effective and efficacious
SO BURNS
LA English
DT Article
DE Skin graft; Vacuum assisted closure device; VAC; Home VAC; hVAC;
   Negative pressure wound therapy
ID RANDOMIZED CONTROLLED-TRIAL; THICKNESS SKIN-GRAFTS; THERAPY; CARE
AB Introduction: The vacuum assisted closure device (VAC) improves wound-healing when utilized as a bolster to secure split thickness skin grafts (STSG). Patients typically remain hospitalized for VAC therapy; however, home VACs (hVAC) are now available. Limited studies examine burns treated with hVAC as a STSG bolster.
   Method: A retrospective study of records from an ABA verified regional burn center was conducted over 23 months. Patients included STSGs for burn. Data points included demographics, burn mechanism and location, graft characteristics, hospital length of stay (LOS), and time to heal.
   Results and discussion: Fifty patients were included, with average age of 39 years (range <1-83 years). Average burn TBSA was 1.27 +/- 1.42 (range 0.05-8.18). Grafted area average was 102.9 +/- 128.1cm(2). The most commonly treated areas were the leg/foot, thigh, and torso (53%, 16%, and 16%, respectively). Average LOS was 1.1 +/- 1.2 days. Mean graft-take was 99.2 +/- 2.8% with one patient undergoing repeat STSG. Average post-operative time to heal was 16 +/- 6 days. A 5-day inpatient stay with a VAC costs an average of $34,635, compared to $9134 for an hVAC over the same period.
   Conclusions: The hVAC is a cost-effective STSG bolster in the burn population for appropriate candidates. Excellent graft-take and low morbidity rates imply that this is an efficacious alternative for STSG bolster. (C) 2016 Elsevier Ltd and ISBI. All rights reserved.
C1 [Mushin, Oren P.; Bogue, Jarrod T.; Esquenazi, Mica D.; Toscano, Nicole; Bell, Derek E.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
C3 University of Rochester
RP Bell, DE (通讯作者)，Univ Rochester, Strong Mem Hosp, Med Ctr, Dept Surg, 601 Elmwood Ave,Box SURG, Rochester, NY 14642 USA.
EM Derek_Bell@urmc.rochester.edu
RI Bogue, Jarrod/KBA-0778-2024
CR [Anonymous], WEIGHT NAT EST HCUP
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NR 17
TC 10
Z9 10
U1 1
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAY
PY 2017
VL 43
IS 3
BP 490
EP 494
DI 10.1016/j.burns.2016.08.038
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA ES9GD
UT WOS:000399863500005
PM 28256293
DA 2026-07-24
ER

PT J
AU Tavusbay, C
   Genc, H
   Cin, N
   Kar, H
   Kamer, E
   Atahan, K
   Haciyanli, M
AF Tavusbay, Cengiz
   Genc, Hudai
   Cin, Necat
   Kar, Haldun
   Kamer, Erdinc
   Atahan, Kemal
   Haciyanli, Mehmet
TI Use of a vacuum-assisted closure system for the management of
   enteroatmospheric fistulae
SO SURGERY TODAY
LA English
DT Article
DE Enteroatmospheric; Fistula; Open abdomen; Abdominal complications;
   Peritonitis; Vacuum-assisted closure
ID OPEN ABDOMEN
AB The aim of this study was to analyze the management of enteroatmospheric fistulae (EAF) in an open abdomen using vacuum-assisted closure (VAC) therapy.
   Eighteen patients (ten male/eight female) were treated in our surgical department for the management of EAF. VAC therapy was used to manage both complex and open abdominal wounds and for effluent control in all patients except one until definitive surgery could be performed or spontaneous closure of the EAF occurred.
   The median age of the patients was 61.1 years (range 29-84 years). Their average hospital stay was 88.89 days (range 22-129 days). The median number of VAC applications was 22.5, and the median duration of VAC applications was 43.6 days (range 14-114 days). Non-surgical spontaneous closure of the fistulae with negative pressure wound therapy could be achieved in four patients. In the other six patients, after the EAF were controlled with VAC therapy, definitive surgery was performed. Primary fascial repair was performed in two patients, and the component separation technique was synchronously performed in another two patients. Ventral hernia repair using polypropylene mesh was performed in a patient 1 year after discharge from the hospital. One patient was discharged with skin grafting plus ileostomy after the EAF was managed with VAC therapy. Eight patients (44.4 %) died due to intraabdominal infections and sepsis, which could not be controlled despite all precautions. No VAC-related complications were observed in this study.
   A VAC system can be successfully used for wound management in the control of fistula effluent in patients with an EAF in an open abdomen until spontaneous fistula closure occurs or definitive fistula surgery can be performed.
C1 [Tavusbay, Cengiz; Genc, Hudai; Cin, Necat; Kar, Haldun; Kamer, Erdinc; Atahan, Kemal; Haciyanli, Mehmet] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Surg, TR-35360 Izmir, Turkey.
C3 Izmir Ataturk Training & Research Hospital; Izmir Katip Celebi
   University
RP Kamer, E (通讯作者)，Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Surg, TR-35360 Izmir, Turkey.
EM erdinc.kamer@gmail.com
RI TAVUSBAY, Cengiz/N-9236-2014; kar, haldun/R-6845-2019; HACIYANLI,
   MEHMET/P-6709-2019; Kamer, Erdinc/A-5245-2009
OI Kamer, Erdinc/0000-0002-5084-5867
CR Aguila DJ, 2011, J AM COLL SURGEONS, V213, pE17, DOI 10.1016/j.jamcollsurg.2011.06.422
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NR 25
TC 29
Z9 36
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD SEP
PY 2015
VL 45
IS 9
BP 1102
EP 1111
DI 10.1007/s00595-014-1020-3
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CP1UE
UT WOS:000359660900004
PM 25163660
DA 2026-07-24
ER

PT J
AU Gabriel, A
   Heinrich, C
   Shores, J
   Cho, D
   Baqai, W
   Moores, D
   Miles, D
   Gupta, S
AF Gabriel, Allen
   Heinrich, Cherrie
   Shores, Jaimie
   Cho, David
   Baqai, Waheed
   Moores, Donald
   Miles, Duncan
   Gupta, Subhas
TI Outcomes of vacuum-assisted closure for the treatment of wounds in a
   paediatric population: case series of 58 patients
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Wound care in paediatrics; VAC Therapy
   System; Vacuum-assisted closure
ID NEGATIVE-PRESSURE; MANAGEMENT; THERAPY
AB Objective: This retrospective case series describes our experiences and outcomes using the vacuum-assisted closure (VAC) Therapy System for the management of difficult acute and chronic wounds in paediatric patients.
   Summary background data: Difficult wounds that cannot be closed primarily can create major challenges in paediatric patient care. Decreasing the time to wound closure is especially critical when managing paediatric patients.
   Methods: A retrospective review of medical records for 58 consecutive paediatric patients treated with VAC therapy was performed. Demographics, diagnosis, length of therapy, time to closure, time to discharge, type of VAC dressing used, dressing change schedule, therapy settings, and complications were recorded for each patient.
   Results: The median age of all 58 patients was 10 years (range, 10 days to 16 years). Fifty-four of the 58 wounds reached full closure. Patients were divided into five different groups according to diagnosis. The median time to closure for each group follows: Group 1 (abdominal wounds) 10 days (range, 3-99 days); Group 2 (surgical soft tissue deficit) 12 days (range, 3-30 days); Group 3 (trauma wounds) 7 days (range, 3-10 days); Group 4 (stage III/IV pressure ulcers) 15 days (range, 14-15 days); Group 5 (fasciotomy wounds) 5 days (range, 5-10 days). No complications were recorded for any of the patients.
   Conclusions: The results demonstrate that VAC therapy may be a viable, safe and effective method of managing this difficult-to-treat population. (C) 2008 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Gabriel, Allen; Heinrich, Cherrie; Shores, Jaimie; Cho, David; Miles, Duncan; Gupta, Subhas] Loma Linda Univ, Dept Plast & Reconstruct Surg, Med Ctr, Loma Linda, CA 92354 USA.
   [Moores, Donald] Loma Linda Univ, Dept Paediat Surg, Med Ctr, Loma Linda, CA 92354 USA.
   [Baqai, Waheed] Loma Linda Univ, Hlth Res Consulting Grp, Loma Linda, CA 92354 USA.
C3 Loma Linda University; Loma Linda University; Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Dept Plast & Reconstruct Surg, Med Ctr, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI Gabriel, Allen/AFK-3548-2022; Gupta, Subhas/C-5458-2018
OI Gupta, Subhas/0000-0001-5091-3922; Shores, Jaimie/0000-0002-4272-1389
CR Arca MJ, 2005, PEDIATR SURG INT, V21, P532, DOI 10.1007/s00383-005-1465-y
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NR 35
TC 32
Z9 38
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD NOV
PY 2009
VL 62
IS 11
BP 1428
EP 1436
DI 10.1016/j.bjps.2008.06.033
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 536XW
UT WOS:000273078200013
PM 18835547
DA 2026-07-24
ER

PT J
AU Schintler, MV
AF Schintler, M. V.
TI Negative pressure therapy: theory and practice
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 6th International Symposium on the Diabetic Foot
CY MAY 10-14, 2011
CL Noordwijkerhout, NETHERLANDS
DE negative pressure therapy; efficacy; practice
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; WOUND THERAPY; STATE
AB Negative pressure (wound) therapy, synonymous with topical negative pressure or vacuum therapy mainly cited as branded VAC (R) (vacuum-assisted closure) therapy, is a mode of therapy used to encourage wound healing. It is used both as primary treatment of chronic and complex wounds and as an adjunct for temporary closure and wound bed preparation preceding surgical procedures such as skin grafts and flap surgery. The device has come into wide and successful use, although the physiological basis of its effect is not yet fully understood, and with a delay, increasingly evidence-based data become available. A meta-analysis was made of peer-reviewed publications (PubMedMedline) chosen on the basis of inclusion of the terms randomized clinical trial, vacuum-assisted closure, and topical negative pressure. Scientific data were evaluated from experimental animal studies, randomized clinical trials, observations of clinical applications, and case reports on all known effects of VAC therapy. Systematic analysis of the data shows efficacy concerning induction of wound healing mechanisms, especially in the early stage. Increased perfusion can be considered proven. Data analysis shows positive efficacy for treatment of infection. Although this therapy appears effective and its superiority to conventional techniques has been demonstrated, there are still some critical votes concerning efficacy. Because its mechanisms of action remain unclear, and because there is still some gap between evidence-based data and the excellent clinical results, further prospective, randomized, blinded studies are needed. Even so, we conclude that vacuum therapy, used when indicated and especially by experienced surgeons, is an excellent tool to support wound healing. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Schintler, M. V.] Med Univ Graz, Div Plast & Reconstruct Surg, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Schintler, MV (通讯作者)，Med Univ Graz, Klin Abt Plast Asthet & Rekonstrukt Chirurg, Auenbruggerpl 29, A-8036 Graz, Austria.
EM michael.schintler@medunigraz.at
CR Adams TST, 2004, TOPICAL NEGATIVE PRE, P212
   [Anonymous], WOUND REPAIR REG
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NR 43
TC 63
Z9 87
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2012
VL 28
SU 1
BP 72
EP 77
DI 10.1002/dmrr.2243
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 880AY
UT WOS:000299377700014
PM 22271727
OA Bronze
DA 2026-07-24
ER

PT J
AU Yang, YH
   Jeng, SF
   Hsieh, CH
   Feng, GM
   Chen, CC
AF Yang, Yi-Hsun
   Jeng, Seng-Feng
   Hsieh, Ching-Hua
   Feng, Guan-Ming
   Chen, Chien Chung
TI Vacuum-assisted closure for complicated wounds in head and neck region
   after reconstruction
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Vacuum-assisted closure (VAC) system; Negative pressure wound therapy
   (NPWT); Head and neck reconstruction; Complicated wound; Fistula
   formation
ID TOPICAL NEGATIVE-PRESSURE; FAILED FREE FLAPS; TRAUMATIC WOUNDS; VAC(R)
   THERAPY; MANAGEMENT; SURGERY; SYSTEM; EXPERIENCE; EXTREMITY; DRESSINGS
AB Objective: The aim of this study is to suggest that negative pressure wound therapy (NPWT) is an excellent alternative for managing complicated wounds after head and neck reconstruction.
   Summary background data: Management of complicated wounds such as wound infection or persistent saliva leakage from poor wound healing with dead space is challenging in head and neck reconstruction. The NPWT is a useful device widely used in treating many complicated wounds. In this study, we applied this device on complicated wounds after head and neck reconstruction and share our experience and modifications.
   Methods: From January 2004 to December 2009, 13 male patients (mean age: 50.0 years) were included. Eleven patients were reconstructed with free flap transfer and the other two patients received a local flap for repair immediately after tumour ablation. Among them, 12 patients (92%) had complicated wounds with infection and one patient (8%) with partial loss of the free flap. Eight of these 13 patients (62%) had saliva leakage and fistula formation. For those who had a free flap transfer, the vacuum-assisted closure (VAC) system was applied with modifications to the complicated wound 2 weeks later, after better neo-vascularisation around the free flap. Watertight suturing on the mucosal side is needed to ensure air sealing and enhance wound healing acquired by the VAC system.
   Results: All wounds demonstrated adequate control of wound infection, quick obliteration of dead space and rapid growth of granulation tissue under the NPWT. Eleven patients (85%) had wound healing with secondary intention; one (8%) needed a further skin grafting; and one patient (8%) needed a free flap transfer due to partial flap loss in a severe wound infection even after the NPWT application. The average duration of the NPWT usage was 10.8 days (4-24 days); most of the wounds healed within 1 week after the NPWT application.
   Conclusion: The NPWT is an excellent alternative for managing complicated wounds after head and neck reconstruction. It is safe and comfortable for the patient and provides good results in infection control, dead space obliteration and improvement of wound healing. (c) 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Yang, Yi-Hsun; Jeng, Seng-Feng; Feng, Guan-Ming; Chen, Chien Chung] I Shou Univ, E Da Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
   [Hsieh, Ching-Hua] Chang Gung Univ, Dept Plast & Reconstruct Surg, Kaohsiung Chang Gung Mem Hosp, Tao Yuan, Taiwan.
   [Hsieh, Ching-Hua] Coll Med, Tao Yuan, Taiwan.
C3 E-Da Hospital; I Shou University; Chang Gung Memorial Hospital; Chang
   Gung University
RP Chen, CC (通讯作者)，I Shou Univ, E Da Hosp, Dept Plast & Reconstruct Surg, Kaohsiung, Taiwan.
EM rason0709@hotmail.com
CR Andrews BT, 2008, ANN OTO RHINOL LARYN, V117, P298, DOI 10.1177/000348940811700410
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NR 31
TC 35
Z9 48
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD AUG
PY 2013
VL 66
IS 8
BP E209
EP E216
DI 10.1016/j.bjps.2013.03.006
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 178IM
UT WOS:000321441300001
PM 23578735
DA 2026-07-24
ER

PT J
AU Narkhede, PS
   Vivekanand
   Vishnu, M
   Sumanthraj, K
   Sravan, CPS
   Lende, V
   Agarwal, L
   Suresh, KR
AF Narkhede, Pravin Sakharam
   Vivekanand
   Vishnu, M.
   Sumanthraj, K.
   Sravan, C. P. S.
   Lende, Vaibhav
   Agarwal, Lawish
   Suresh, K. R.
TI Resource Utilization and Cost Effectiveness of Negative Pressure Wound
   Therapy (NPWT) Versus Moist Wound Therapy (MWT) in Management of
   Diabetic Foot Transmetatarsal Amputation (TMA)
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacuum dressing; Diabetic
   transmetatarsal amputation; Cost effectivity; Resource utilization
ID VACUUM-ASSISTED CLOSURE; ULCERS; TRIAL
AB To evaluate resource utilization and direct economic costs of care for patients treated with negative pressure wound therapy (NPWT) in comparison with standard moist wound therapy (MWT) for preparation of diabetic foot TMA wounds for skin grafting. We retrospectively analyzed 56 patients who underwent transmetatarsal amputation (TMA) for infected diabetic foot from January 2014 to April 2015 at Jain Institute of Vascular sciences (JIVAS), Bangalore. Twenty-eight patients received negative pressure wound therapy (NPWT) (VAC (R) KCI, TX, USA) dressing while 28 received standard MWT daily. Resource utilization, revascularization procedures, number of secondary procedures (debridement), and total cost for wound bed preparation were calculated in both groups. There was no significant difference in both groups regarding age, gender, comorbidities, and number of revascularization procedures. All patients were having ankle brachial index (ABI) more than 0.8 or ankle pressures more than 80mmHg before enrolling to study group. MWT group required more debridement (15 vs. 2; P=0.0001). Average number of dressing changes performed per patients were 25 (range 20-32) for MWT versus 3 (range 2-5) in NPWT group. MWT group had more OPD visits compare to NPWT (14 vs. 2; P value =0.0001). Mean duration for wound bed preparation was 24.61 +/- 3.20days (range 20-32days) in MWT group and significantly higher than NPWT group 9.11 +/- 2.38days (range 6-15days) (P=0.0001; 95% CI difference 13.99 to 17.01). The average total cost for wound bed preparation of TMA wound was Rs 26,875 +/- 6810.5 in MWT group and was significantly higher than compared to Rs 23,089.29 +/- 6637.5 in NPWT group (P=0.03; 95% CI difference 182.54 to 7388.89). NPWT resulted in lower resource utilization, reduced costs, and acceleration of wound bed preparation for diabetic foot TMA wound in comparison to standard MWT.
C1 [Narkhede, Pravin Sakharam; Vivekanand; Vishnu, M.; Sumanthraj, K.; Sravan, C. P. S.; Lende, Vaibhav; Agarwal, Lawish; Suresh, K. R.] Jain Inst Vasc Sci JIVAS, Dept Vasc & Endovasc Surg, Bengaluru 560052, India.
RP Narkhede, PS (通讯作者)，Jain Inst Vasc Sci JIVAS, Dept Vasc & Endovasc Surg, Bengaluru 560052, India.
EM drpravin7474@gmail.com; jainvascular@hotmail.com;
   narkhede_pravin@yahoo.com; sumanthkolalu@yahoo.co.in;
   sravan_cps@yahoo.co.in; vaibhavinpeds@gmail.com; kalsuresh48@gmail.com
RI Madhu, Vishnu/AAX-6620-2021
CR Amit kumar CJain, 2011, J DIABETIC FOOT COMP, V3, P13
   [Anonymous], 2012, 2012 WOUND CARE PROD
   [Anonymous], 2000, J FOOT ANKLE SURG S5
   [Anonymous], 2011, 2011 WOUND CARE PROD
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NR 22
TC 1
Z9 1
U1 0
U2 19
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD OCT
PY 2018
VL 80
IS 5
BP 457
EP 460
DI 10.1007/s12262-017-1630-2
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GX4SX
UT WOS:000447726900011
DA 2026-07-24
ER

PT J
AU Luo, XB
   Tang, XY
   Ma, YZ
   Zhang, YG
   Fang, SZ
AF Luo, Xiaobo
   Tang, Xiangyu
   Ma, Yuanzheng
   Zhang, Yonggang
   Fang, Shuzhi
TI The efficacy of negative pressure wound therapy in treating sacroiliac
   joint tuberculosis with a chronic sinus tract: a case series
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Sacroiliac joint; Tuberculosis; Negative pressure wound therapy;
   Chemotherapy; Sinus
ID VACUUM-ASSISTED CLOSURE; C-REACTIVE PROTEIN
AB Objective: Tuberculous sacroiliitis with abscess accounts for approximately 50 % of all sacroiliac joint tuberculosis cases. Tuberculous abscesses spread into the sacroiliac joint capsule, subcutaneous tissue, and the skin, and finally becomes a skin sinus. As there are no previous reports about sacroiliac joint tuberculosis with a chronic sinus, we evaluated its clinical characteristics and management by negative pressure wound therapy.
   Methods: A retrospective analysis of 12 patients with sacroiliac joint tuberculosis with chronic sinuses treated between January 2005 and January 2010 was conducted. Patients were treated with negative pressure wound therapy (NPWT). Treatment was divided into three phases: control phase, standard dressing changes daily for 4 weeks; interphase washout period, dressing changes every 3 days for 1 week; and intervention phase, no dressing changes until minimal sinus tract drainage (<5 ml per 24 h). Outcomes including the sinus healing time and the drainage volume were evaluated.
   Results: The mean follow-up was 37.1 months. Sinus healing was observed at an average of 25.25 +/- 7.23 (range, 20-42) days after initial treatment. The mean volume of drainage did not change during the control phase, but decreased from 29.17 +/- 16.63 to 0.25 +/- 0.87 ml in the intervention phase. The mean daily reduction of wound volume, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in the intervention phase was greater than in the control phase (P < 0.05). Anti-tubercular therapy was administered an average of 14.00 +/- 2.95 (range, 12-18) months. ESR and CRP returned to normal within 3 months after the sinus closure. Bony fusion was observed in 5 (41.7 %) patients, and fibrous ankylosis in the other patients at last follow-up. All patients healed uneventfully.
   Conclusions: Early diagnosis of sacroiliac joint tuberculosis with a chronic sinus can be difficult. NPWT provides better healing of sacroiliac joint tuberculosis with a chronic sinus than standard dressing changes.
C1 [Luo, Xiaobo; Tang, Xiangyu; Zhang, Yonggang] Chinese Peoples Liberat Army, Gen Hosp, Dept Orthoped, Hosp 301, Beijing 100853, Peoples R China.
   [Luo, Xiaobo; Ma, Yuanzheng] Chinese Peoples Liberat Army, Hosp 309, Dept Orthoped, Beijing 100091, Peoples R China.
   [Tang, Xiangyu; Fang, Shuzhi] Chinese Peoples Liberat Army, Hosp 264, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Zhang, YG (通讯作者)，Chinese Peoples Liberat Army, Gen Hosp, Dept Orthoped, Hosp 301, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM yonggangzhang23@yeah.net
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NR 33
TC 5
Z9 9
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD AUG 6
PY 2015
VL 10
AR 120
DI 10.1186/s13018-015-0250-4
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CO1IH
UT WOS:000358907300001
PM 26243259
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lin, FY
   Huang, PY
   Cheng, HT
AF Lin, Fu-Yu
   Huang, Pin-Yi
   Cheng, Hsu-Tang
TI Systematic review of negative pressure wound therapy for head and neck
   wounds with fistulas: Outcomes and complications
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE fistula; head and neck reconstruction; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; RECONSTRUCTION
AB Fistula formation in head and neck wounds is considered one of the most challenging complications that a head and neck reconstructive surgeon may encounter. The current mainstay of treatment is aggressive surgical debridement followed by vascularised soft tissue coverage. Negative pressure wound therapy (NPWT) has been successfully used for the closure of complicated wounds for decades. This study analysed the outcomes and complications of NPWT in the management of head and neck wounds with fistulas. A systematic search of studies published between January 1966 and September 2019 was conducted using the PubMed, MEDLINE, EMBASE, and SCOPUS databases and using the following key words: "negative pressure wound therapy," "head and neck," and "fistula." We included human studies with abstract and full text available. Analysed endpoints were rate of fistula closure, follow-up duration, and complications if present. Nine retrospective case series (Level IV evidence) that collectively included 122 head and neck wounds with orocutaneous fistulas, pharyngocutaneous fistulas, and salivary contamination were examined. The number of patients included in each study ranged from 5 to 64. The mode of NPWT varied among the included studies, with most adopting a continuous pressure of -125 mm Hg. Mean durations of NPWT ranged from 3.7 to 23 days, and the reported fistula closure rate ranged from 78% to 100%. To achieve complete wound healing, six studies used additional procedures after stopping NPWT, including conventional wound dressings and vascularised tissue transfer. Information regarding follow up was provided in only three of the nine studies, where patients were followed for 5, 10, and 18 months. No serious adverse events were reported. NPWT for head and neck wounds with fistulas may be considered a safe treatment method that yields beneficial outcomes with a low risk of complications. The current data originated mainly from studies with low levels of evidence characterised by heterogeneity. Therefore, definitive recommendations based on these data cannot be offered. Additional high-quality trials are warranted to corroborate the findings of this systematic review.
C1 [Lin, Fu-Yu; Huang, Pin-Yi] China Med Univ, Dept Med Educ, China Med Univ Hosp, Sch Med, Taichung, Taiwan.
   [Lin, Fu-Yu; Huang, Pin-Yi] China Med Univ, Dept Neurol, China Med Univ Hosp, Sch Med, Taichung, Taiwan.
   [Cheng, Hsu-Tang] Asia Univ, Coll Med & Hlth Sci, Asia Univ Hosp, Div Plast & Reconstruct Surg,Dept Surg, 222 Fuxin Rd, Taichung 41354, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Asia University Taiwan
RP Cheng, HT (通讯作者)，Asia Univ, Coll Med & Hlth Sci, Asia Univ Hosp, Div Plast & Reconstruct Surg,Dept Surg, 222 Fuxin Rd, Taichung 41354, Taiwan.
EM hsutangcheng@gmail.com
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NR 30
TC 7
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2020
VL 17
IS 2
BP 251
EP 258
DI 10.1111/iwj.13264
EA NOV 2019
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA KR3MH
UT WOS:000494631200001
PM 31696637
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Shweiki, E
   Gallagher, KE
AF Shweiki, Ehyal
   Gallagher, Kathy E.
TI Negative pressure wound therapy in acute, contaminated wounds:
   documenting its safety and efficacy to support current global practice
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Contaminated; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED-TRIAL; MANAGEMENT; EXPERIENCE;
   DRESSINGS; SYSTEM; AMPUTATION; CARE
AB Negative pressure wound therapy (NPWT) is in widespread use and its role in wound care is expanding worldwide. It is estimated that 300 million acute wounds are treated globally each year. Currently, sporadic data exist to support NPWT in acutely contaminated wounds. Despite lack of data, use of negative pressure wound therapy in such cases is increasing across the globe. We retrospectively reviewed 86 consecutive patients, totalling 97 contaminated wounds. All wounds were Class IV based on US Center for Disease Control criteria. Sepsis criteria were present in 78/86 (91%) of patients. All patients were managed with NPWT. Wound type, degree of tissue destruction, presence of infection, wound dimension, timing of initial NPWT, type and timing of wound closure and patient comorbidities were recorded. Outcome endpoints included durability of wound closure and death. Wound location was 41/97 (42%) in the torso; 56/97 (58%) at the extremities. Tissue necrosis was present in 84/97 (87%) of wounds. Infection was present in 86/97 (89%) of wounds. Average wound size was 619 cm2 when square surface area measured; 786 cm3 when volume measurements taken. Mean time to wound closure was 17 days, median 10 days and mode 6 days. Durability of wound closure 73/79 (92%). Deaths were noted in 6/86 (7%) of patients. No deaths appeared related to NPWT. Contemporary NPWT related acute wound care is expanding empirically, in quantity and scope across the globe. However, several areas of concern are known regarding this contemporary use of NPWT in acute wounds. Thus, it is important to assess the safety and efficacy of such expanded empiric NPWT practice. Based on our findings with NPWT in the largest known patient cohort of this type, NPWT appears safe and effective in managing acute, contaminated wounds including patients meeting sepsis criteria. These findings provide evidence-based support for current worldwide empiric NPWT-related acute wound care.
C1 [Shweiki, Ehyal] Thomas Jefferson Univ Hosp, Dept Surg, Philadelphia, PA 19107 USA.
   [Gallagher, Kathy E.] Christiana Care Hlth Syst, Dept Surg, Newark, DE 19713 USA.
C3 Thomas Jefferson University; Christiana Care Health System
RP Gallagher, KE (通讯作者)，Christiana Care Hlth Syst, Dept Surg, MAP2 Suite 3301, Newark, DE 19713 USA.
EM KaGallagher@christianacare.org
CR [Anonymous], 2010, NEG PRESS WOUND THER
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NR 40
TC 21
Z9 24
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2013
VL 10
IS 1
BP 13
EP 43
DI 10.1111/j.1742-481X.2012.00940.x
PG 31
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 073MK
UT WOS:000313746900005
PM 22420782
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Jeong, JW
   Lee, S
   Park, JH
AF Jeong, Ji Won
   Lee, Seungkeun
   Park, Jun Ho
TI Closed-incision negative pressure wound therapy (NPWT) in elderly
   patients following sacral pressure sore reconstruction
SO BMC GERIATRICS
LA English
DT Article
DE Pressure sore; Pressure ulcer; Sacral sore; Negative pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; ULCERS; FLAP; PROLIFERATION; PREVALENCE;
   PREVENTION; CARE
AB Background Pressure sores significantly affect elderly patients, with the sacrum being especially vulnerable, often due to its proximity to the anus and potential for fecal contamination. Despite preventive measures such as frequent repositioning and specialized cushions, some sores still necessitate surgical intervention. Postoperative care focuses on monitoring, hygiene, and pressure alleviation. This study assessed the efficacy of Closed-Incision Negative Pressure Wound Therapy (CI-NPWT) for postoperative wound management in patients with sacral pressure sores treated with local flaps. Methods A retrospective analysis was performed on sacral sore patients who underwent reconstructive surgery from March 2019 through April 2023. Surgical procedures involved debridement and wound coverage using gluteal artery perforator-based fasciocutaneous flaps, followed by postoperative monitoring. Patients were grouped into conventional monitoring or NPWT management, with the latter utilizing the INFOV.A.C. The therapy unit was calibrated to 125 mmHg. Data on patient demographics, flap metrics, fluid drainage amounts, and six-month postoperative outcomes were collected, and then analyzed with SPSS Statistics. Results In this study of 52 patients with sacral pressure sores, the NPWT group (n = 25) showed significantly fewer flap complications and a lower drainage volume on the seventh postoperative day (mean 17.2 cc) compared to the conventional dressing group (mean 27.8 cc, P < 0.05). No postoperative complications were observed in the NPWT group, whereas the conventional group (n = 27) experienced one infection and three cases of dehiscence. Both groups achieved a 100% flap survival rate. Conclusion Closed-incision negative pressure wound therapy (CI-NPWT) shows promise in reducing wound dehiscence and infection rates in elderly patients undergoing sacral pressure sore reconstruction with local flaps. However, further research with larger, randomized studies is needed to confirm its effectiveness as an alternative to conventional postoperative care. Trial registration. The study was retrospectively registered by the Institutional Review Board of Seoul Metropolitan Government-Seoul National University Boramae Medical Center (No. 20-2023-25, Date: Mar. 24 2023).
C1 [Jeong, Ji Won; Park, Jun Ho] Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
   [Lee, Seungkeun] Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Coll Med, Jomaru Ro 170, Bucheon 14584, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Soonchunhyang University
RP Park, JH (通讯作者)，Seoul Natl Univ, SMG SNU Boramae Med Ctr, Dept Plast & Reconstruct Surg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea.
EM jsean1@naver.com
FU Seoul Metropolitan Government-Seoul National University Boramae Medical
   Center Research Fund [0420230016]
FX This research was supported by a clinical research grant-in-aid from
   Seoul Metropolitan Government-Seoul National University Boramae Medical
   Center Research Fund (no. 0420230016)
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NR 41
TC 6
Z9 7
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD NOV 4
PY 2024
VL 24
IS 1
AR 906
DI 10.1186/s12877-024-05526-9
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA L0S6B
UT WOS:001347908900001
PM 39497041
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yuan, K
   Quah, A
   Hwee, J
   Xu, R
   Wu, YJ
   Wen, NH
   Han, PC
AF Yuan, Kong
   Quah, Alison
   Hwee, Jolie
   Xu, Roland
   Wu Yijun
   Wen, Ng Hui
   Han, Pek Chong
TI Use of negative pressure wound therapy on locoregional flaps: a
   case-control study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE flap reconstruction; incisional negative pressure wound therapy;
   locoregional flaps; negative pressure wound therapy; NPWT; perforator
   flap; reconstructive surgery; wound; wound care; wound dressing; wound
   healing
ID VACUUM-ASSISTED CLOSURE; MAJOR MUSCLE FLAP; LOWER-EXTREMITY;
   COMPLICATIONS; EXPERIENCES; SAFETY
AB Objective: The use of negative pressure wound therapy (NPWT) is ubiquitous in the management of complex wounds. Extending beyond the traditional utility of NPWT, it has been used after reconstructive flap surgery in a few case series. The authors sought to investigate the outcomes of NPWT use on flap reconstruction in a case-control study.
   Method: Patients who underwent flap reconstruction between November 2017 and January 2020 were reviewed for inclusion in the study, and divided into an NPWT group and a control group. For patients in the NPWT group, NPWT was used directly over the locoregional flap immediately post-surgery for 4-7 days, before switching to conventional dressings. The control group used conventional dressing materials immediately post-surgery. Outcome measures such as flap necrosis, surgical site infections (SSIs), wound dehiscence as well as time to full functional recovery and hospitalisation duration were evaluated.
   Results: Of the 138 patients who underwent flap reconstruction, 37 who had free flap reconstructions were excluded, and 101 patients were included and divided into two groups: 51 patients in the NPWT group and 50 patients in the control group. Both groups had similar patient demographics, and patient and wound risk factors for impaired wound healing. Results showed that there was no statistically significant difference between flap necrosis, SSIs, wound dehiscence, hospitalisation duration as well as functional recovery rates. Cost analysis showed that the use of NPWT over flaps for the first seven postoperative days may potentially be more cost effective in our setting.
   Conclusion: In this study, the appropriate use of NPWT over flaps was safe and efficacious in the immediate postoperative setting, and was not inferior to the conventional dressings used for reconstructive flap surgery. The main benefits of NPWT over flaps include better exudate management, oedema reduction and potential cost savings. Further studies would be required to ascertain any further benefit.
C1 [Yuan, Kong; Quah, Alison; Hwee, Jolie; Xu, Roland; Wu Yijun; Han, Pek Chong] Khoo Teck Puat Hosp, Dept Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
   [Wen, Ng Hui] Tan Tock Seng Hosiptal, Dept Gen Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
RP Han, PC (通讯作者)，Khoo Teck Puat Hosp, Dept Surg, Plast Reconstruct & Aesthet Surg Serv, Singapore, Singapore.
EM pekch@rocketmail.com
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   Honrado Carlo P, 2005, Facial Plast Surg Clin North Am, V13, P203, DOI 10.1016/j.fsc.2004.11.007
   Horch RE, 2015, J WOUND CARE, V24, P21, DOI 10.12968/jowc.2015.24.Sup4b.21
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Kairinos N, 2013, PLAST RECONSTR SURG, V132, P978, DOI 10.1097/PRS.0b013e31829f4ad9
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P601, DOI 10.1097/PRS.0b013e318196b97b
   Kairinos N, 2009, PLAST RECONSTR SURG, V123, P589, DOI 10.1097/PRS.0b013e3181956551
   Lance S, 2016, J PLAST RECONSTR AES, V69, P519, DOI 10.1016/j.bjps.2015.11.010
   Lo Torto F, 2017, INT WOUND J, V14, P1335, DOI 10.1111/iwj.12808
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   Papp AA, 2019, INT WOUND J, V16, P394, DOI 10.1111/iwj.13045
   Qiu SS, 2016, MICROSURG, V36, P467, DOI 10.1002/micr.30027
   Quintero JI, 2021, PRS-GLOB OPEN, V9, DOI 10.1097/GOX.0000000000003725
   Semsarzadeh NN, 2015, PLAST RECONSTR SURG, V136, P592, DOI 10.1097/PRS.0000000000001519
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   Wu ML, 2018, J PLAST RECONSTR AES, V71, P1665, DOI 10.1016/j.bjps.2018.07.021
   Yu PX, 2017, J RECONSTR MICROSURG, V33, P358, DOI 10.1055/s-0037-1599076
NR 35
TC 5
Z9 6
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2023
VL 32
SU 4
BP S5
EP S13
DI 10.12968/jowc.2023.32.Sup4.S5
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA D7FB4
UT WOS:000970336500002
PM 37029982
DA 2026-07-24
ER

PT J
AU Ousey, KJ
   Atkinson, RA
   Williamson, JB
   Lui, S
AF Ousey, Karen J.
   Atkinson, Ross A.
   Williamson, J. Bradley
   Lui, Steve
TI Negative pressure wound therapy (NPWT) for spinal wounds: a systematic
   review
SO SPINE JOURNAL
LA English
DT Review
DE Infection; Spine; Systematic review; Negative pressure wound therapy;
   Wound
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; CLINICAL-EXPERIENCE;
   PEDIATRIC-PATIENTS; SUCTION DRAINAGE; RISK-FACTORS; SURGERY; INFECTIONS;
   FUSION; MANAGEMENT
AB BACKGROUND CONTEXT: The management of postoperative spinal wound complication remains a challenge, with surgical site infection (SSI) incidence rates ranging from 0.4% to 20% after spinal surgery. Negative pressure wound therapy (NPWT) has been highlighted as an intervention that may stimulate healing and prevent SSI. However, the wound healing mechanism by NPWT and its effectiveness in spinal wounds still remain unclear.
   PURPOSE: To systematically search, critically appraise, and summarize randomized controlled trials (RCTs) and non-RCTs assessing the effectiveness of NPWT in patients with a spinal wound.
   STUDY DESIGN: Systematic review.
   METHODS: A systematic review based on search strategies recommended by the Cochrane Back and Wounds Review Groups was undertaken using Cochrane Library, MEDLINE, EMBASE, and CINAHL databases. Any publications between 1950 and 2011 were included. Funding to undertake the review was received from the University of Huddersfield Collaborative Venture Fund ($4,820) and KCI Medical ($4,820).
   RESULTS: Ten retrospective studies and four case studies of patients with spinal wound complication were included in this systematic review. No RCTs were found. Only one study described more than 50 patients. Generally, a pressure of -125 mm Hg was used in adults. Duration of NPWT in situ ranged from 3 to 186 days. Wound healing was assessed every 2 to 3 days and generally completed between 7 days and 16 months. Negative pressure wound therapy is contraindicated in the presence of active cerebrospinal fluid leak, metastatic or neoplastic disease in the wound or in patients with an allergy to the NPWT dressing and in those with a bleeding diathesis.
   CONCLUSIONS: Published reports are limited to small retrospective and case studies, with no reports of NPWT being used as a prophylactic treatment. Larger prospective RCTs of NPWT are needed to support the current evidence that it is effective in treating spinal wound complications. In addition, future studies should investigate its use as a prophylactic treatment to prevent infection and report data relating to safety and health economics. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ousey, Karen J.; Lui, Steve] Univ Huddersfield, Sch Human & Hlth Sci, Huddersfield HD1 3DH, Yorks, England.
   [Atkinson, Ross A.; Williamson, J. Bradley] Salford Royal NHS Fdn Trust, Greater Manchester Neurosci Ctr, Salford M6 8HD, Lancs, England.
   [Atkinson, Ross A.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Salford M6 8HD, Lancs, England.
C3 University of Huddersfield; Salford Royal NHS Foundation Trust; Salford
   Royal NHS Foundation Trust; University of Manchester
RP Ousey, KJ (通讯作者)，Univ Huddersfield, Sch Human & Hlth Sci, Huddersfield HD1 3DH, Yorks, England.
EM k.j.ousey@hud.ac.uk
RI ; Atkinson, Ross/C-3286-2017; Ousey, Karen/W-1881-2018
OI Lui, Steve/0000-0002-4161-6181; Atkinson, Ross/0000-0001-8976-2754;
   Ousey, Karen/0000-0002-6993-9425
FU University of Huddersfield Collaborative Venture Fund; KCI Medical
FX Funding to undertake the review was received from the University of
   Huddersfield Collaborative Venture Fund and KCI Medical. No other
   conflict of interest is declared.
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NR 55
TC 63
Z9 70
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD OCT
PY 2013
VL 13
IS 10
BP 1393
EP 1405
DI 10.1016/j.spinee.2013.06.040
PG 13
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 258AP
UT WOS:000327430300039
PM 23981819
OA Green Published
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Malmsjö, M
   Hansson, J
   Hlebowicz, J
   Ingemansson, R
AF Lindstedt, Sandra
   Malmsjo, Malin
   Hansson, Johan
   Hlebowicz, Joanna
   Ingemansson, Richard
TI Macroscopic changes during negative pressure wound therapy of the open
   abdomen using conventional negative pressure wound therapy and NPWT with
   a protective disc over the intestines
SO BMC SURGERY
LA English
DT Article
DE negative pressure wound therapy open abdomen; macroscopic changes;
   intestinal wall
ID VACUUM-ASSISTED CLOSURE; TRIAL COMPARING POLYGLACTIN-910-MESH; TEMPORARY
   ABDOMINAL CLOSURE; VENTRAL HERNIA RATE; FASCIAL CLOSURE
AB Background: Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) than with other wound management techniques. However, the method has occasionally been associated with increased development of fistulae. We have previously shown that NPWT induces ischemia in the underlying small intestines close to the vacuum source, and that a protective disc placed between the intestines and the vacuum source prevents the induction of ischemia. In the present study we compare macroscopic changes after 12, 24, and 48 hours, using conventional NPWT and NPWT with a protective disc between the intestines and the vacuum source.
   Methods: Twelve pigs underwent midline incision. Six animals underwent conventional NPWT, while the other six pigs underwent NPWT with a protective disc inserted between the intestines and the vacuum source. Macroscopic changes were photographed and quantified after 12, 24, and 48 hours of NPWT.
   Results: The surface of the small intestines was red and mottled as a result of petechial bleeding in the intestinal wall in all cases. After 12, 24 and 48 hours of NPWT, the area of petechial bleeding was significantly larger when using conventional NPWT than when using NPWT with the protective disc (9.7 +/- 1.0 cm(2) vs. 1.8 +/- 0.2 cm(2), p < 0.001, 12 hours), (14.5 +/- 0.9 cm(2) vs. 2.0 +/- 0.2 cm(2), 24 hours) (17.0 +/- 0.7 cm(2) vs. 2.5 +/- 0.2 cm(2) with the disc, p < 0.001, 48 hours)
   Conclusions: The areas of petechial bleeding in the small intestinal wall were significantly larger following conventional NPWT after 12, 24 and 48 hours, than using NPWT with a protective disc between the intestines and the vacuum source. The protective disc protects the intestines, reducing the amount of petechial bleeding.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Malmsjo, Malin; Hlebowicz, Joanna; Ingemansson, Richard] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Inst Surg Sci, Fac Med, Uppsala, Sweden.
   [Hlebowicz, Joanna] Lund Univ, Dept Med, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Uppsala University; Lund University
RP Lindstedt, S (通讯作者)，Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953; Lindstedt, Sandra/0000-0003-4484-6473
CR Becker HP, 2007, SCAND J SURG, V96, P263, DOI 10.1177/145749690709600402
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   Kaplan M, 2004, OSTOMY WOUND MANAG S, V50
   Kaplan Mark, 2004, Ostomy Wound Manage, V50, P1
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   Trevelyan S L, 2009, J Wound Care, V18, P24
NR 18
TC 8
Z9 9
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2482
J9 BMC SURG
JI BMC Surg.
PD APR 29
PY 2011
VL 11
AR 10
DI 10.1186/1471-2482-11-10
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 840OB
UT WOS:000296449000001
PM 21529362
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kiliç, A
   Özkaya, U
   Sökücü, S
   Basilgan, S
   Kabukçuoglu, Y
AF Kilic, Ayhan
   Ozkaya, Ufuk
   Sokucu, Sami
   Basilgan, Seckin
   Kabukcuoglu, Yavuz
TI Use of vacuum-assisted closure in the topical treatment of surgical site
   infections
SO ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
LA Turkish
DT Article
DE Negative-pressure wound therapy; wound healing; wound infection/therapy
ID PRESSURE WOUND THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; MANAGEMENT;
   DEVICE; TRAUMA
AB Objectives: This study was designed to evaluate the results of vacuum-assisted closure in the topical treatment of surgical site infections.
   Methods: Vacuum therapy was performed in 17 patients (10 males, 7 females; mean age 60 20 years) using the VAC system (Vacuum-Assisted Closure, Kinetic Concept Inc) for the treatment of surgical site infections. Infective wounds were in the hip (n=6), crus (n=5), knee (n=3), sacrum (n=2), and hand (n=1). The causative organism for infections was gram-positive bacteria in 15 patients (88.2%), and six patients (35.3%) had nosocomial infections. The wounds were treated with a negative pressure of 100-125 mmHg applied continuously for the first two days, and then intermittently for the following days. The mean follow-up period was 11 +/- 6 months.
   Results: The mean duration of vacuum therapy was 16 +/- 4 days and the mean length of hospitalization was 31 +/- 19 days. The patients underwent a mean number of three surgical procedures (range 1 to 6) before vacuum therapy. The mean amount of discharge from the wound was 500 +/- 150 ml. Tissue edema and discharge problems were resolved in all the wounds and a hygienic and dry-looking surgical site was attained. In 11 patients (64.7%), clinical and bacteriologic eradication of infections was achieved at the surgical site through antibiotic use and vacuum therapy. Six patients with nosocomial infections continued to receive antibiotic treatment following resolution of surgical site problems. The mean wound area showed a significant reduction from 36 +/- 14 cm(2) to 11 +/- 10 cm(2) following vacuum therapy (p<0.05). Only two patients (11.8%) required further surgical interventions for the closure of wound site. Two patients (11.8%) complained of pain associated with vacuum application.
   Conclusion: Besides its topical advantages in the care of infected wounds, vacuum-assisted closure provides a more rapid and comfortable treatment opportunity, representing a reliable alternative to conventional wound care methods.
C1 [Kilic, Ayhan; Ozkaya, Ufuk; Sokucu, Sami; Basilgan, Seckin; Kabukcuoglu, Yavuz] Taksim Egitim & Arastirma Hastanesi, Ortopedi & Travmatol Klin, TR-34433 Istanbul, Turkey.
C3 Istanbul Gaziosmanpasa Taksim Training & Research Hospital
RP Kiliç, A (通讯作者)，Taksim Egitim & Arastirma Hastanesi, Ortopedi & Travmatol Klin, TR-34433 Istanbul, Turkey.
EM kilicayhan@yahoo.com
RI Kilic, Ayhan/A-6577-2018
OI Sokucu, Sami/0000-0001-9079-100X
CR Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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NR 28
TC 8
Z9 9
U1 0
U2 3
PU TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY
PI ISTANBUL
PA SEHREMINI MAH KOYUNCU SK CIGDEM APT NO 4 D 5 FATIH, ISTANBUL, 00000,
   TURKEY
SN 1017-995X
J9 ACTA ORTHOP TRAUMATO
JI Acta Orthop. Traumatol. Turc.
PD JUL-AUG
PY 2009
VL 43
IS 4
BP 336
EP 342
DI 10.3944/AOTT.2009.336
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 500XB
UT WOS:000270338400009
PM 19809231
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Imaizumi, K
   Kasajima, H
   Terashima, K
   Furukawa, N
   Ito, K
   Fukasawa, T
   Odagiri, T
   Yamana, D
   Tsuruga, Y
   Umehara, M
   Kurushima, M
   Nakanishi, K
AF Imaizumi, Ken
   Kasajima, Hiroyuki
   Terashima, Kazutoshi
   Furukawa, Naoe
   Ito, Keiichiro
   Fukasawa, Takumu
   Odagiri, Tadashi
   Yamana, Daisuke
   Tsuruga, Yosuke
   Umehara, Minoru
   Kurushima, Michihiro
   Nakanishi, Kazuaki
TI Prophylactic negative-pressure wound therapy using the open method is
   associated with reduced surgical site infection after emergency lower
   gastrointestinal surgery: A retrospective cohort study with propensity
   score analyses
SO MEDICINE
LA English
DT Article
DE gastrointestinal; negative-pressure wound therapy; open method;
   perforation; prophylactic negative-pressure wound therapy; surgical site
   infection
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; COMPLICATIONS; INCISIONS
AB This study investigates the association between prophylactic negative-pressure wound therapy (pNPWT) using the open method and incisional surgical site infection (SSI) following emergency lower gastrointestinal surgery. We retrospectively examined 210 consecutive patients who underwent emergency surgery for lower gastrointestinal tract perforation or necrosis at a single center between January 2018 and March 2023. Outcomes were compared between patients who received pNPWT and those who received conventional wound management. Propensity score analyses included multivariate analysis using the propensity score in the crude cohort, inverse probability of treatment weighting, and 1:2 nearest-neighbor matching. The primary endpoint was the incidence of incisional SSI and the secondary endpoints were wound healing time, postoperative hospital stay, identification of incisional SSI risk factors, and determination of optimal pNPWT management. In the crude cohort (pNPWT = 41, conventional = 169), incisional SSI occurred in 11 (26.8%) and 65 (38.5%) patients, respectively (P = .227). After propensity score analyses, pNPWT was significantly associated with a reduction in incisional SSI, with odds ratios (95% confidence interval) of 0.344 (0.147-0.804; P = .002), 0.260 (0.103-0.794; P = .002), and 0.285 (0.106-0.763; P = .012) in the multivariate analysis, inverse probability of treatment weighting, and propensity score-matched cohort (pNPWT = 30, conventional = 60), respectively. Wound healing time and postoperative hospital stay did not differ significantly between the groups. Risk factors for incisional SSI were poor American Society of Anesthesiologists Physical Status and perforation, with the addition of conventional wound management. Early application of pNPWT (<= 2 days postoperatively) further reduced the incidence of SSI (17.6% vs 71.4%; P = .010). In propensity score analyses, pNPWT was associated with a significant reduction in incisional SSI in contaminated abdominal wounds after lower gastrointestinal surgery. Early application may enhance its effectiveness. pNPWT should be considered for high-risk patients undergoing emergency abdominal surgery.
C1 [Imaizumi, Ken; Kasajima, Hiroyuki; Ito, Keiichiro; Fukasawa, Takumu; Odagiri, Tadashi; Yamana, Daisuke; Tsuruga, Yosuke; Umehara, Minoru; Kurushima, Michihiro; Nakanishi, Kazuaki] Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
   [Terashima, Kazutoshi; Furukawa, Naoe] Hakodate Municipal Hosp, Dept Wound Ostomy & Continence Nurse, Hakodate, Hokkaido, Japan.
RP Imaizumi, K (通讯作者)，Hakodate Municipal Hosp, Dept Gastroenterol Surg, 1-10-1 Minatocho, Hakodate, Hokkaido 0418680, Japan.
EM imaken1983@gmail.com; hiro-kasajima@hospital.hakodate.hokkaido.jp;
   k-terashima@hospital.hakodate.hokkaido.jp;
   n-hurukawa@hospital.hakodate.hokkaido.jp; k.ito199212@gmail.com;
   hockeytf@gmail.com; odgrtds118@outlook.com;
   d-yamana@hospital.hakodate.hokkaido.jp;
   y-tsuruga@hospital.hakodate.hokkaido.jp;
   m-umehara@hospital.hakodate.hokkaido.jp;
   m-kurushima@hospital.hakodate.hokkaido.jp;
   k-nakanishi@hospital.hakodate.hokkaido.jp
RI Imaizumi, Ken/ABW-2302-2022
FU Japanese Society for the Promotion of Science KAKENHI [25K18891]
FX This study was supported by the Japanese Society for the Promotion of
   Science KAKENHI (grant no. 25K18891).
CR Abadía P, 2021, SURG INFECT, V22, P234, DOI 10.1089/sur.2019.309
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NR 34
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN 27
PY 2025
VL 104
IS 26
AR e43099
DI 10.1097/MD.0000000000043099
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4KA4A
UT WOS:001519858200025
PM 40587691
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Eneroth, M
   van Houtum, WH
AF Eneroth, Magnus
   van Houtum, William H.
TI The value of debridement and Vacuum-Assisted Closure (VAC) Therapy in
   diabetic foot ulcers
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article; Proceedings Paper
CT 5th International Symposium on Diabetic Foot
CY MAY 09-12, 2007
CL Noordwijkerhout, NETHERLANDS
DE diabetes; foot ulcers; debridement; VAC
ID PRESSURE WOUND THERAPY; MAGGOT THERAPY; DRESSINGS; TRIAL
AB Background Treatment of diabetic foot ulcers includes a number of different regimes such as glycaemic control, re-vascularization, surgical, local wound treatment, offloading and other non-surgical treatments. Although considered the standard of care, the scientific evidence behind the various debridements used is scarce. This presentation will focus on debridement and V.A.C. Therapy, two treatments widely used in patients with diabetes and foot ulcers.
   Methods A review of existing literature on these treatments in diabetic foot ulcers, with focus on description of the various types of debridements used, the principles behind negative pressure wound therapy (NPWT) using the V.A.C. Therapy system and level of evidence.
   Results Five randomized controlled trials (RCT) of debridement were identified; three assessed the effectiveness of a hydrogel as a debridement method, one evaluated surgical debridement and one evaluated larval therapy. Pooling the three hydrogel RCTs suggested that hydrogels are significantly more effective than gauze or standard care in healing diabetic foot ulcers. Surgical debridement and larval therapy showed no significant benefit. Other debridement methods such as enzyme preparations or polysaccharide beads have not been evaluated in RCTs of people with diabetes. More than 300 articles have been published on negative pressure wound therapy, including several small RCTs and a larger multi-centre RCT of diabetic foot ulcers. Negative pressure wound therapy seems to be a safe and effective treatment for complex diabetic foot wounds, and could lead to a higher proportion of healed wounds, faster healing rates, and potentially fewer re-amputations than standard care.
   Conclusions Although debridement of the ulcer is considered a prerequisite for healing of diabetic foot ulcers, the grade of evidence is quite low. This may be due to a lack of studies rather than lack of effect. Negative pressure wound therapy seems to be safe and effective in the treatment of some diabetic foot ulcers, although there is still only one well-performed trial that evaluates the effect. Copyright (C) 2008 John Wiley & Sons, Ltd.
C1 [Eneroth, Magnus] Malmo Univ Hosp, Dept Orthopaed, S-20502 Malmo, Sweden.
   [van Houtum, William H.] Spaarne Hosp Hoofddorp, Dept Internal Med, NL-2134 TM Hoofddorp, Netherlands.
C3 Lund University; Skane University Hospital; Spaarne Hospital
RP Eneroth, M (通讯作者)，Malmo Univ Hosp, Dept Orthopaed, S-20502 Malmo, Sweden.
EM magnus.eneroth@med.lu.se
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 34
TC 51
Z9 66
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY-JUN
PY 2008
VL 24
SU 1
BP S76
EP S80
DI 10.1002/dmrr.852
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 308RS
UT WOS:000256408300016
PM 18393328
DA 2026-07-24
ER

PT J
AU Wu, WH
   Qiu, JW
   Fang, YC
   Wang, Y
AF Wu, Weihang
   Qiu, Jinwei
   Fang, Yongchao
   Wang, Yu
TI A portable vacuum-sealing drainage device
SO ASIAN JOURNAL OF SURGERY
LA English
DT Letter
C1 [Wu, Weihang] Fujian Med Univ, Hosp Joint Logist Team 900, Dept Gen Surg, 156 North Xi-Er Huan Rd, Fuzhou, Fujian, Peoples R China.
   [Qiu, Jinwei] Fujian Med Univ, Fuzhou Gen Hosp, Clin Inst, Fuzhou, Fujian, Peoples R China.
   [Fang, Yongchao; Wang, Yu] 900 Hosp Joint Logist Team, Dept Genery Surg, 156 North Xi-Er Huan Rd, Fuzhou, Fujian, Peoples R China.
C3 Fujian Medical University; Fujian Medical University
RP Fang, YC; Wang, Y (通讯作者)，900 Hosp Joint Logist Team, Dept Genery Surg, 156 North Xi-Er Huan Rd, Fuzhou, Fujian, Peoples R China.
EM 1126275030@qq.com; fishwang@hotmail.com
FU Application Basics General Project of PLA [2018ZX09J18]; National
   Science and Technology Major Projects for "Major New Drugs Innovation
   and Development";  [CLB21J016]
FX The study was supported by the Application Basics General Project of PLA
   for "application of self-expanding one-way exhaust sealing device in the
   first aid of open pneumothorax battlefield" (CLB21J016) , and the
   National Science and Technology Major Projects for "Major New Drugs
   Innovation and Development" (2018ZX09J18) .
CR Faust E, 2021, PLAST RECONSTR SURG, V147, p16S, DOI 10.1097/PRS.0000000000007607
   Wu LJ, 2022, INT WOUND J, V19, P1449, DOI 10.1111/iwj.13741
   Xue X, 2021, INT WOUND J, V18, P639, DOI 10.1111/iwj.13565
NR 3
TC 2
Z9 2
U1 2
U2 14
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD FEB
PY 2023
VL 46
IS 2
BP 1025
EP 1026
DI 10.1016/j.asjsur.2022.07.098
EA FEB 2023
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 8Z1NA
UT WOS:000933152600001
PM 36028397
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Bohac, M
   Mikusz, K
   Fedeles, J Sr
AF Bohac, M.
   Mikusz, K.
   Fedeles, J., Sr.
TI Application of negative pressure wound therapy in scalp reconstruction
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE scalp reconstruction; negative pressure therapy; polymorbidity
ID VACUUM-ASSISTED CLOSURE; DEFECTS
AB Scalp defects in old polymorbid patients are still therapeutic challenge for reconstructive surgeons. We present the case of a male who underwent an excessive tumour resection with the unsuccessful skin graft coverage. The patient developed a progressive skin graft necrosis and infection with an exposure of calvarial bone. Initial surgical debridement and topical treatment resulted in an excessive bone exposure. We decided to use a negative pressure therapy after multiple bone trephinations, to improve growth of new vital tissue in bone-exposed area. This maneuverer, followed by a split thickness skin graft coverage, allowed a progressive defect healing. In such old polymorbid patient, calvarial bone trephinations with a negative pressure therapy could be considered to achieve effective and considerable results (Fig. 4, Ref. 16). Text in PDF www.elis.sk.
C1 [Bohac, M.; Fedeles, J., Sr.] Comenius Univ, Fac Med, Univ Hosp Bratislava, Dept Plast Surg, SK-82606 Bratislava, Slovakia.
   [Mikusz, K.] Ctr Burns Treatment, Dept Plast Surg, Siemianowice Slaskie, Poland.
C3 Comenius University Bratislava; Slovak Medical University Bratislava
RP Bohac, M (通讯作者)，Comenius Univ, Fac Med, Univ Hosp Bratislava, Dept Plast Surg, Ruzinovska 6, SK-82606 Bratislava, Slovakia.
EM bohac.md@gmail.com
OI Bohac, Martin/0000-0003-4625-1326
CR [Anonymous], THEORY PRACTICE VACU
   [Anonymous], J CUTAN AESTHET SURG
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NR 16
TC 3
Z9 3
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2015
VL 116
IS 12
BP 719
EP 721
DI 10.4149/BLL_2015_141
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CZ7LL
UT WOS:000367280800005
PM 26924140
OA Bronze
DA 2026-07-24
ER

PT J
AU Lou, WJ
   Zou, K
   Yu, ZB
   Qin, S
   Wang, K
   Che, B
AF Lou, Wenjie
   Zou, Kai
   Yu, Zhongbin
   Qin, Song
   Wang, Kai
   Che, Biao
TI Cefazolin sodium pentahydrate combined with vacuum sealing drainage in
   the treatment of open fracture complicated with soft tissue injury
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Article
DE Fractures; open; Soft tissue injuries; Cefazolin; Negative-pressure
   wound therapy
ID WOUND-INFECTION; THERAPY; CLOSURE
AB OBJECTIVE: To investigate the clinical efficacy of cefazolin sodium pentahydrate combined with vacuum sealing drainage (VSD) in the treatment of open fracture complicated with soft tissue injury.
   METHODS: Sixty-three patients with open fracture complicated with soft tissue injury were divided into observation (n = 33) and control (n = 30) groups. After surgical reduction, fixation, and repair of the fractures, the control group was treated with VSD for 10 days, and the observation group was treated with cefazolin sodium pentahydrate based on VSD for 10 days. The infection control time was recorded. After treatment, the pain of patients was evaluated. Before and after treatment, the serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha), cortisol, epinephrine, norepinephrine, and glucose were detected. After 6 months of treatment, the total effective rate of the treatment was evaluated.
   RESULTS: The infection control time and Visual Analogue Scale score after treatment in the observation group were significantly lower than in the control group, respectively (P < 0.05). After the treatment, the serum levels of CRP, IL-6, IL-8, TNF-alpha, cortisol, epinephrine, norepinephrine, and glucose in each group were significantly lower than before the treatment (P <0.05), and each index in observation was significantly lower than in the control group (P < 0.05).
   CONCLUSIONS: In the treatment of open fractures complicated with soft tissue injury, cefazolin sodium pentahydrate combined with VSD can effectively reduce inflammation and stress, thus improving the treatment efficacy.
C1 [Lou, Wenjie; Zou, Kai; Yu, Zhongbin; Qin, Song; Wang, Kai; Che, Biao] Gen Hosp Yangtze River Shipping, Dept Orthoped, 5 Huiji Rd, Wuhan 430010, Peoples R China.
   [Lou, Wenjie; Zou, Kai; Yu, Zhongbin; Qin, Song; Wang, Kai; Che, Biao] Wuhan Brain Hosp, 5 Huiji Rd, Wuhan 430010, Peoples R China.
RP Che, B (通讯作者)，Gen Hosp Yangtze River Shipping, Dept Orthoped, 5 Huiji Rd, Wuhan 430010, Peoples R China.; Che, B (通讯作者)，Wuhan Brain Hosp, 5 Huiji Rd, Wuhan 430010, Peoples R China.
EM chebiaowh@163.com
RI /AAS-8070-2020
FU Yangtze River Administration of Navigational Affairs [201810009]
FX This work was supported by Yangtze River Administration of Navigational
   Affairs (No. 201810009).
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NR 19
TC 4
Z9 5
U1 0
U2 1
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD APR
PY 2020
VL 66
IS 4
BP 430
EP 436
DI 10.1590/1806-9282.66.4.430
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MA3CI
UT WOS:000541794900012
PM 32578775
OA Green Published, Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jiang, X
   Xu, Y
   Jiao, GQ
   Jing, ZH
   Bu, FY
   Zhang, J
   Wei, LY
   Rong, XS
   Li, MQ
AF Jiang, Xia
   Xu, Yong
   Jiao, Guoqing
   Jing, Zhaohui
   Bu, Fanyu
   Zhang, Jie
   Wei, Liuyan
   Rong, Xiaosong
   Li, Mingqiu
TI The combined application of antibiotic-loaded bone cement and vacuum
   sealing drainage for sternal reconstruction in the treatment of deep
   sternal wound infection
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE Deep sternal wound infection; Antibiotic-loaded bone cement; Vacuum
   sealing drainage
ID ACUTE KIDNEY INJURY; CARDIAC-SURGERY; MEDIASTINITIS; VANCOMYCIN;
   PREVENTION; FLAPS
AB Background Deep sternal wound infection (DSWI) is a rare but serious complication after median sternotomy, and treatment success depends mainly on surgical experience. Traditional treatment methods for DSWI include complete debridement, vacuum sealing drainage wound therapy and sometimes transposition of muscle flap. This study aimed to evaluate the utility of antibiotic-loaded bone cement combined with vacuum sealing drainage on DSWI and explore the effect of this treatment on lung function. Methods Between January 2018 and December 2019, we treated 12 patients suffering a mediastinitis and open thorax using antibiotic-loaded bone cement combined with vacuum sealing drainage. Subsequently, the blood and local concentration of antibiotic were measured. The patient characteristics, pulmonary function, were retrospectively analyzed. Subjects were followed up for 12 months. Results There were no intraoperative deaths. All patients' healing wounds were first-stage healing without complications and reoperation, the mean hospital stay was 20.2 +/- 3.5 days. Local vancomycin concentrations largely exceeded the ones needed for their efficacy while little antibiotic was found in the blood. Pulmonary function testing was improved 2 weeks after the operation. No infection reoccurred in12-month follow-up. Conclusions The antibiotic-loaded bone cement combined with vacuum sealing drainage might be an effective method for the sternal reconstruction of deep sternal wound infection and it can improve the patient's lung function in a short time.
C1 [Jiang, Xia; Xu, Yong; Jiao, Guoqing; Jing, Zhaohui; Zhang, Jie; Wei, Liuyan; Rong, Xiaosong; Li, Mingqiu] Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiangsu, Peoples R China.
   [Bu, Fanyu] Soochow Univ, Wuxi Peoples Hosp 9, Dept Chron Wound, Wuxi 214062, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Jiangnan University; Soochow University -
   China
RP Rong, XS; Li, MQ (通讯作者)，Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Peoples Hosp, Dept Cardiovasc Surg, 299 Qingyang Rd, Wuxi 214203, Jiangsu, Peoples R China.
EM rxswx@163.com; LMQ.2109@163.com
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NR 32
TC 7
Z9 9
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD AUG 26
PY 2022
VL 17
IS 1
AR 209
DI 10.1186/s13019-022-01951-2
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 4A3FF
UT WOS:000844991000001
PM 36028875
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Asher, SA
   White, HN
   Golden, JB
   Magnuson, JS
   Carroll, WR
   Rosenthal, EL
AF Asher, Scott A.
   White, Hilliary N.
   Golden, Joseph B.
   Magnuson, J. Scott
   Carroll, William R.
   Rosenthal, Eben L.
TI Negative Pressure Wound Therapy in Head and Neck Surgery
SO JAMA FACIAL PLASTIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; ORGAN PRESERVATION THERAPY; SALVAGE TOTAL
   LARYNGECTOMY; SOFT-TISSUE; PHARYNGOCUTANEOUS FISTULA; VASCULAR-SURGERY;
   MUSCLE FLAP; RECONSTRUCTION; MANAGEMENT; COMPLICATIONS
AB IMPORTANCE Negative pressure wound therapy has been shown to accelerate healing. There is a paucity of literature reporting its use as a tool to promote wound healing in head and neck reconstruction.
   OBJECTIVE To review 1 institution's experience with negative pressure dressings to further describe the indications, safety, and efficacy of this technique in the head and neck.
   DESIGN, SETTING, AND PARTICIPANTS Retrospective case series at a tertiary care academic hospital. One hundred fifteen patients had negative pressure dressings applied between April 2005 and December 2011. Data were gathered, including indications, details of negative pressure dressing use, adverse events, wound healing results, potential risk factors for compromised wound healing (defined as previous radiation therapy, hypothyroidism, or diabetes mellitus), and wound characteristics (complex wounds included those with salivary contamination, bone exposure, great vessel exposure, in the field of previous microvascular free tissue transfer, or in the case of peristomal application in laryngectomy).
   EXPOSURE Negative pressure wound therapy utilized after head and neck reconstruction.
   MAIN OUTCOMES AND MEASURES Indications for therapy, length and number of dressing applications, identification of wound healing risk factors, classification of wound complexity, wound healing results, and adverse events related to the use of the device.
   RESULTS Negative pressure wound therapy was used primarily for wounds of the neck (94 of 115 patients [81.7%]) in addition to other head and neck locations (14 of 115 patients [12.2%]), and free tissue transfer donor sites (7 of 115 patients [6.1%]). The mean (SD) wound size was 5.6 (5.0) cm. The mean number of negative pressure dressing applications was 1.7 (1.2), with an application length of 3.7 (1.4) days. Potential risk factors for compromised wound healing were present in 82 of 115 patients (71.3%). Ninety-one of 115 patients (79.1%) had complex wounds. Negative pressure dressings were used in wounds with salivary contamination (n = 64), bone exposure (n = 40), great vessel exposure (n = 25), previous free tissue transfer (n = 55), and peristomal application after laryngectomy (n = 32). Adverse events occurred in 4 of 115 patients (3.5%).
   CONCLUSIONS AND RELEVANCE Negative pressure wound therapy in head and neck surgery is safe and has potential to be a useful tool for complex wounds in patients with a compromised ability to heal.
C1 [Asher, Scott A.; White, Hilliary N.; Golden, Joseph B.; Magnuson, J. Scott; Carroll, William R.; Rosenthal, Eben L.] Univ Alabama Birmingham, Sch Med, Div Otolaryngol Head & Neck Surg, Dept Surg, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Rosenthal, EL (通讯作者)，Div Otolaryngol Head & Neck Surg, BDB Suite 56,1808 Seventh Ave South, Birmingham, AL 35233 USA.
EM oto@uab.edu
RI Rosenthal, Eben/KLC-3513-2024; Magnuson, Jason/ABX-9283-2022
OI Rosenthal, Eben/0000-0003-0294-5203; 
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NR 56
TC 21
Z9 24
U1 0
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6076
EI 2168-6092
J9 JAMA FACIAL PLAST SU
JI JAMA Facial Plast. Surg.
PD MAR-APR
PY 2014
VL 16
IS 2
BP 120
EP 126
DI 10.1001/jamafacial.2013.2163
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AH2OX
UT WOS:000335961900008
PM 24357046
DA 2026-07-24
ER

PT J
AU Nakagawa, Y
   Uchida, H
   Hinoki, A
   Shirota, C
   Sumida, W
   Makita, S
   Amano, H
   Okamoto, M
   Takimoto, A
   Ogata, S
   Takada, S
   Kato, D
   Gohda, Y
AF Nakagawa, Yoichi
   Uchida, Hiroo
   Hinoki, Akinari
   Shirota, Chiyoe
   Sumida, Wataru
   Makita, Satoshi
   Amano, Hizuru
   Okamoto, Masamune
   Takimoto, Aitaro
   Ogata, Seiya
   Takada, Shunya
   Kato, Daiki
   Gohda, Yousuke
TI Combined negative pressure wound therapy with irrigation and dwell time
   and artificial dermis prevents infection and promotes granulation
   formation in a ruptured giant omphalocele: a case report
SO BMC PEDIATRICS
LA English
DT Article
DE Negative pressure wound therapy; Negative pressure wound therapy with
   irrigation and dwell time; Omphalocele
ID VACUUM-ASSISTED CLOSURE; TISSUE DEFECTS; INSTILLATION; MANAGEMENT;
   MORTALITY
AB Background Omphalocele is a congenital abdominal wall defect of the umbilical cord insertion site. A giant omphalocele, with a fascial defect > 5 cm in diameter and/or containing > 50% of the liver within the hernia sac, can be challenging for pediatric surgeons. Recently, negative pressure wound therapy has been reported as an effective management for giant omphaloceles; however, it is not recommended for an infected wound with necrotic tissue as it may exacerbate infection. We adopted negative pressure wound therapy with irrigation and dwell time (NPWTi-d) for a case of a ruptured giant omphalocele. Artificial membranes, followed by artificial dermis, were used to promote fibrous capsule formation, and then NPWTi-d was used to promote granulation while controlling infection. However, studies have not been conducted regarding NPWTi-d for ruptured giant omphaloceles; hence, we present our treatment experience with NPWTi-d for a giant omphalocele. Case presentation The patient was a boy born at 38 weeks and 3 days of gestation, weighing 1896 g. He was diagnosed with a ruptured giant omphalocele with a total liver and intestine defect hole of 10 cm x 10 cm. The patient underwent silo placement using an artificial mesh, followed by plicating the artificial mesh at 4 days of age. The herniated viscera were gradually reduced into the abdominal cavity; however, the defect size was still large. Hence, a collagen-based artificial dermis was patched on the defect hole. After creating a fresh and smooth granulated tissue, NPWTi-d was applied at 33 days of age to promote granulation and control infection. We used the 3 M (TM) V.A.C.(R) Ulta Therapy Unit with 3 M (TM) VeraFlo (TM) therapy. NPWTi-d was stopped at 60 days of age when the granulation tissue was well formed including at the artificial dermis site. The wound was managed with prostandin ointment and appropriate debridement, resulting in complete epithelialization at 5 months of age. Conclusions Artificial membranes followed by artificial dermis were used to promote a fibrous capsule and artificial dermis granulation, which protects against organ damage. NPWTi-d achieved better control of infection and promoted wound healing. NPWTi-d combined with artificial dermis can effectively treat ruptured giant omphaloceles.
C1 [Nakagawa, Yoichi; Uchida, Hiroo; Shirota, Chiyoe; Sumida, Wataru; Makita, Satoshi; Amano, Hizuru; Okamoto, Masamune; Takimoto, Aitaro; Ogata, Seiya; Takada, Shunya; Kato, Daiki; Gohda, Yousuke] Nagoya Univ, Dept Pediat Surg, Grad Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
   [Hinoki, Akinari] Nagoya Univ, Grad Sch Med, Dept Rare Intractable Canc Anal Res, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
C3 Nagoya University; Nagoya University
RP Uchida, H (通讯作者)，Nagoya Univ, Dept Pediat Surg, Grad Sch Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM hiro2013@med.nagoya-u.ac.jp
RI ; UCHIDA, Hiroo/E-4437-2015; Nakagawa, Yoichi/HKF-0307-2023; Hinoki,
   Akinari/Q-1122-2015; Takimoto, Aitaro/LTE-5262-2024; Sumida,
   Wataru/QLU-7315-2026
OI Okamoto, Masamune/0009-0008-8401-1191; UCHIDA,
   Hiroo/0000-0002-1818-6697; Nakagawa, Yoichi/0000-0003-1570-8661; 
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NR 30
TC 6
Z9 6
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD NOV 26
PY 2022
VL 22
IS 1
AR 680
DI 10.1186/s12887-022-03755-8
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 6M3ZK
UT WOS:000888809300003
PM 36435753
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Baek, SO
   Shin, J
   Song, JK
   Lee, JY
AF Baek, Sang Oon
   Shin, Jeonghwan
   Song, Jong Keun
   Lee, Jun Yong
TI Multimodal Conservative Treatment of Complicated Open Wound After Total
   Knee Replacement Arthroplasty in Patients With Comorbidities
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE dermatotraction; negative pressure wound therapy; total knee replacement
   arthroplasty; rehabilitation; wound healing
ID VACUUM-ASSISTED CLOSURE; TOTAL HIP; SHOELACE TECHNIQUE;
   DIABETES-MELLITUS; OPERATIVE TIME; RISK-FACTOR; REVISION; OUTCOMES;
   SMOKING; SKIN
AB Total knee replacement arthroplasty is a common procedure and postoperative wound complications are sometimes inevitable. Although invasive reconstructive surgery may be an option for nonhealed wounds, such procedures can limit early rehabilitation, adversely affecting the range of joint motion. Patients can achieve a wider range of motion if they undergo early rehabilitation with a conservative approach. From 2015 to 2017, 5 patients with comorbidities who underwent total knee replacement arthroplasty were referred to the reconstructive surgery department for nonhealed open wounds. Depending on their comorbidities and conditions, the patients underwent negative-pressure wound therapy based on multimodal conservative treatment. During the treatment, the patients continued rehabilitation. In the 5 patients, the mean duration of complete wound healing was 65.2 days (range = 57-81), during which all open wounds were well healed. For final wound closure, the patients underwent skin grafting, dermatotraction, or collagen dressing. Four patients achieved ranges of joint motion over 100 degrees after treatment. We believe that early coverage is important for open wounds. For complicated open wounds after total knee replacement arthroplasty in patients with comorbidities, less invasive multimodal treatment along with early rehabilitation may be more effective to achieve adequate final range of joint motion.
C1 [Baek, Sang Oon; Shin, Jeonghwan; Song, Jong Keun; Lee, Jun Yong] Catholic Univ Korea, Dept Plast & Reconstruct Surg, Coll Med, Seoul, South Korea.
C3 Catholic University of Korea
RP Lee, JY (通讯作者)，Catholic Univ Korea, Dept Plast & Reconstruct Surg, Incheon St Marys Hosp, Coll Med, 56 Dongsu Ro, Incheon 21431, South Korea.
EM ps.jylee@catholic.ac.kr
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NR 41
TC 3
Z9 4
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2021
VL 20
IS 4
BP 347
EP 354
AR 1534734620919315
DI 10.1177/1534734620919315
EA MAY 2020
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA WN7JW
UT WOS:000532787300001
PM 32380929
DA 2026-07-24
ER

PT J
AU Ottosen, B
   Pedersen, BD
AF Ottosen, B.
   Pedersen, B. D.
TI Patients' experiences of NPWT in an outpatient setting in Denmark
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE patient experience; negative pressure wound therapy;
   phenomenological-hermeneutic approach
ID VACUUM-ASSISTED CLOSURE; WOUNDS
AB Objective: To study patients' experiences of negative pressure wound therapy (NPWT) used for wounds of various aetiologies in the outpatient setting and the influences on daily life.
   Method: In this qualitative study, a phenomenological-hermeneutic approach was used. Ten patients underwent qualitative interviews regarding their NPWT treatment. The French philosopher, Ricoeur's, theory of interpretation guided the data analysis, which included three levels: naive reading, structural analysis and critical interpretation and discussion.
   Results: The patients experienced a high level of dependency on the equipment and a greater confidence as treatment proceeded. There is a link between treatment and tolerance. Duration of treatment influenced the patients' ability to cope with it and the patients gradually developed an acceptance of the technology. The support of relatives was important, particularly after delivery of a baby and wound treatment following caesarean section. Some patients were embarrassed due to the appearance and smell of the exudate.
   Conclusion: Use of NPWT clearly influences patients' daily life. Patients have a feeling of being dependent on and attached to the equipment, and they experienced embarrassment about odour, anxiety and uneasiness in relation to complications, a need for relatives' support and other social-relation issues. It was important to include relatives as a resource and make use of the opportunity they presented to assist patients during information sessions about treatment.
C1 [Ottosen, B.] Odense Univ Hosp, Dept Plast Surg, Univ Ctr Wound Healing, Odense, Denmark.
   [Pedersen, B. D.] Univ So Denmark, Fac Hlth Sci, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark
RP Ottosen, B (通讯作者)，Odense Univ Hosp, Dept Plast Surg, Univ Ctr Wound Healing, Odense, Denmark.
EM birthe.ottosen@ouh.regionsyddanmark.dk
CR Bolas Niamh, 2012, Br J Community Nurs, VSuppl, pS30
   Bourdieu Pierre., 1998, STATE NOBILITY, VFirst
   Franczyk M, 2009, PLAST RECONSTR SURG, V124, P854, DOI 10.1097/PRS.0b013e3181b038b4
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NR 14
TC 12
Z9 14
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2013
VL 22
IS 4
BP 197
EP 206
DI 10.12968/jowc.2013.22.4.197
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA 118WW
UT WOS:000317058300006
PM 23702673
DA 2026-07-24
ER

PT J
AU Krticka, M
   Ira, D
   Bilik, A
   Rotschein, P
   Svancara, J
AF Krticka, M.
   Ira, D.
   Bilik, A.
   Rotschein, P.
   Svancara, J.
TI Fasciotomy closure using negative pressure wound therapy in lower leg
   compartment syndrome
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE lower leg; acute compartment syndrome; NPWT; split thickness graft;
   fasciotomy; wound closure
ID VACUUM-ASSISTED CLOSURE; INCISION FASCIOTOMY; TIBIAL FRACTURES;
   SINGLE-INCISION; COMPLICATIONS; DEVICE; TRAUMA
AB BACKGROUND: Fasciotomy wounds can be a major contributor to length of stay for patients as well as a difficult reconstructive challenge.
   OBJECTIVES: To evaluate lower leg fasciotomy wound closure outcomes comparing treatment with combined dressing fabric (COM) and negative pressure wound therapy (NPWT) in combination with elastic dynamic ligature (EDL).
   METHODS: Retrospective study of 63 patients who underwent lower leg fasciotomy due to injury treated from January 2008 to December 2015 at the Department of Trauma Surgery, University Hospital Brno. Of these fasciotomy wounds 42 received a NPWT treatment in combination with EDL, 21 were treated only with COM. Fasciotomy wounds were closed either with primary suture or in case of persisting oedema and skin retraction the defect was covered with split thickness skin graft.
   RESULTS: There was statistically significantly higher rate of primary wound closure using the NPWT versus traditional dressing (p = 0.015). Median time to definitive wound closure or skin grafting was shorter in the NPWT group. Number of dressing changes was lower in the NPWT group (p=0.008).
   CONCLUSION: NPWT combined with elastic dynamic ligature offers many advantages for fasciotomy wound closure in comparison with traditional techniques (Tab. 5, Fig. 3, Ref. 21). Text in PDF www.elis.sk.
C1 [Krticka, M.; Ira, D.; Bilik, A.; Rotschein, P.] Univ Hosp, Dept Trauma Surg, Brno, Czech Republic.
   [Svancara, J.] Masaryk Univ, Inst Biostat & Anal, Brno, Czech Republic.
C3 University Hospital Brno; Institute of Biostatistics & Analyses; Masaryk
   University
RP Krticka, M (通讯作者)，Univ Hosp, Dept Trauma Surg, Brno, Czech Republic.; Krticka, M (通讯作者)，Dept Trauma Surg, Jihlavska 20, C-60200 Brno, Czech Republic.
EM milan.krticka@fnbrno.cz
RI Ira, Daniel/ABD-7164-2020; Krtička, Milan/ABE-1428-2020; Rotschein,
   Pavel/ABF-9297-2020; Švancara, Jan/G-5285-2017
OI Ira, Daniel/0000-0002-7332-9830; Krtička, Milan/0000-0002-7101-1896; 
CR Al-Dadah OQ, 2008, INJURY, V39, P1204, DOI 10.1016/j.injury.2008.03.029
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NR 21
TC 13
Z9 16
U1 0
U2 9
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2016
VL 117
IS 12
BP 710
EP 714
DI 10.4149/BLL_2016_136
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EI5VQ
UT WOS:000392564800005
PM 28127967
OA gold
DA 2026-07-24
ER

PT J
AU Kilpadi, DV
   Stechmiller, JK
   Childress, B
   Cowan, L
   Comerio, M
   Kieswetter, K
   Schultz, G
AF Kilpadi, Deepak V.
   Stechmiller, Joyce K.
   Childress, Beverly
   Cowan, Linda
   Comerio, Melissa
   Kieswetter, Kristine
   Schultz, Gregory
TI Composition of wound fluid from pressure ulcers treated with negative
   pressure wound therapy using VAC® therapy in home health or extended
   care patients:: A pilot study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MATRIX-METALLOPROTEINASE; TISSUE INHIBITORS;
   HUMAN SKIN; EXPRESSION; TIMP-1
AB The purpose of this pilot study was to characterize changes in concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, matrix metalloproteinase (MMP)-3, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 in wound fluid collected from pressure ulcers in adults treated with negative pressure wound therapy (NPWT; V.A.C.(R) Therapy, KCl, Son Antonio, Tex). Wound fluids were collected from 8 patients with Stage III or IV pressure ulcers in home care and extended care settings. Concentrations of analytes were measured immediately prior to initiation of NPWT (Day 0) and at Days 1, 3, and 7 continuous NPWT. There were statistically significant (P < 0.05) decreases from baseline in the levels of MMP-3 (Day 0 > [Day 1 similar to Day 3 similar to Day 7]), MMP-9 (Day 0 > [Day 1 similar to Day 3]), and MMP-3:TIMP-1 ratios (Day 0 > [Day 1 similar to Day 3 similar to Day 7]). No other significant differences were detected. Previous studies have shown a consistent decrease in protease levels to have prognostic value for healing. Thus, the change in composition of fluids from pressure ulcers treated with NPWT may be beneficial to wound healing.
C1 Kinet Concepts Inc, Global R&D, San Antonio, TX 78249 USA.
   Univ Florida, Coll Nursing, Gainesville, FL 32611 USA.
   N Florida S Georgia Vet Hlth Syst, Rehabil Outcomes Res Ctr Excellence, Gainesville, FL USA.
   Univ Florida, Coll Med, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Kilpadi, DV (通讯作者)，Kinet Concepts Inc, Global R&D, 6203 Farinon, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
RI Cowan, Linda/JLK-9224-2023
CR [Anonymous], AHCPR PUB
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NR 40
TC 13
Z9 14
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2006
VL 18
IS 5
BP 119
EP 128
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 047AX
UT WOS:000237853300004
DA 2026-07-24
ER

PT J
AU Demaria, M
   Stanley, BJ
   Hauptman, JG
   Steficek, BA
   Fritz, MC
   Ryan, JM
   Lam, NA
   Moore, TW
   Hadley, HS
AF Demaria, Marco
   Stanley, Bryden J.
   Hauptman, Joe G.
   Steficek, Barbara A.
   Fritz, Michele C.
   Ryan, John M.
   Lam, Nathaniel A.
   Moore, Trevor W.
   Hadley, Heather S.
TI Effects of Negative Pressure Wound Therapy on Healing of Open Wounds in
   Dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE;
   POSTSTERNOTOMY MEDIASTINITIS; EXTREMITY WOUNDS; MANAGEMENT;
   TRANSDUCTION; GAUZE; COST; RECONSTRUCTION
AB Objective: To compare the effect of negative pressure wound therapy (NPWT) with standard-of-care management on healing of acute open wounds in dogs.
   Study Design: Prospective, controlled, experimental study.
   Animals: Adult dogs (n = 10).
   Methods: Full-thickness 4cm x 2 cm wounds were surgically created on each antebrachium and in each dog were randomized to receive either NPWT or standard wound dressings (CON) for 21 days. Dressing changes and wound evaluations were made at 8 time points. First appearance of granulation tissue, smoothness of granulation tissue, exuberance, percent epithelialization, and percent contraction were compared. Biopsies for histopathology were taken, and histologic scores determined, at 5 time points, and aerobic bacterial wound cultures performed at 2 time points.
   Results: Granulation tissue appeared significantly earlier, and was smoother and less exuberant in NPWT wounds compared with CON wounds. Percent contraction in NPWT wounds was less than CON wounds after Day 7. Percent epithelialization in NPWT wounds was less than CON wounds on Days 11, 16, 18, and 21. Histologic scores for acute inflammation were higher in NPWT on Day 3, and lower on Day 7, than CON wounds. Bacterial load was higher in NPWT on Day 7.
   Conclusion: NPWT accelerated appearance of smooth, nonexuberant granulation tissue; however, prolonged use of NPWT impaired wound contraction and epithelialization.
C1 [Demaria, Marco; Stanley, Bryden J.; Hauptman, Joe G.; Fritz, Michele C.; Lam, Nathaniel A.; Moore, Trevor W.; Hadley, Heather S.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
   [Steficek, Barbara A.] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48824 USA.
   [Ryan, John M.] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH9 1QH, Midlothian, Scotland.
C3 Michigan State University; Michigan State University; University of
   Edinburgh
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
OI Fritz, Michele/0000-0002-4146-2469
FU College of Veterinary Medicine, Michigan State University, East Lansing,
   MI.
FX Funded by an Endowed Research Funds grant, College of Veterinary
   Medicine, Michigan State University, East Lansing, MI.
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NR 83
TC 66
Z9 78
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD AUG
PY 2011
VL 40
IS 6
BP 658
EP 669
DI 10.1111/j.1532-950X.2011.00849.x
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 803GK
UT WOS:000293569600002
PM 21770975
DA 2026-07-24
ER

PT J
AU Konagaya, K
   Yamamoto, H
   Nishida, T
   Morita, T
   Suda, T
   Isogai, J
   Murayama, H
   Ogino, H
AF Konagaya, Kensuke
   Yamamoto, Hiroyuki
   Nishida, Tomoki
   Morita, Tomotaka
   Suda, Tomoyuki
   Isogai, Jun
   Murayama, Hiroyuki
   Ogino, Hidemitsu
TI Negative-pressure wound therapy to treat thoracic empyema with
   COVID-19-related persistent air leaks: A case report
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE COVID-19; pneumothorax; persistent air leaks; empyema; open-window
   thoracostomy; negative-pressure wound therapy
ID OPEN-WINDOW THORACOSTOMY; PNEUMOTHORAX; PNEUMONIA
AB The novel coronavirus disease (COVID-19) has resulted in a global pandemic. Recently, COVID-19-related pneumothorax has gained attention because of the associated prolonged hospital stay and high mortality. While most cases of pneumothorax respond well to conservative and supportive care, some cases of refractory pneumothorax with persistent air leaks (PALs) do not respond to conventional therapies. There is a lack of evidence-based management strategies to this regard. We describe the case of a 73-year-old man with COVID-19-related acute respiratory distress syndrome (ARDS) who developed delayed tension pneumothorax with PALs caused by alveolopleural fistulas. Despite chest tube drainage, autologous blood pleurodesis, and endoscopic procedures, the PALs could not be closed, and were complicated by thoracic empyema. Subsequent minimally invasive open-window thoracostomy (OWT) with vacuum-assisted closure (VAC) therapy helped successfully control the refractory PALs. Serial chest computed tomography monitoring was useful for the early detection of the pneumothorax and understanding of its temporal relationship with air-filled lung cysts. Our case provides a new perspective to the underlying cause of refractory pneumothorax with PALs, secondary to COVID-19-related ARDS, and underscores the potential of OWT with VAC therapy as a therapeutic alternative in such cases.
C1 [Konagaya, Kensuke; Suda, Tomoyuki; Murayama, Hiroyuki; Ogino, Hidemitsu] Narita Tomisato Tokushukai Hosp, Dept Surg, Chiba, Japan.
   [Yamamoto, Hiroyuki] Narita Tomisato Tokushukai Hosp, Dept Cardiovasc Med, Chiba, Japan.
   [Suda, Tomoyuki] Shonan Kamakura Gen Hosp, Dept Gen Surg, Yokohama, Kanagawa, Japan.
   [Morita, Tomotaka] Narita Tomisato Tokushukai Hosp, Dept Anesthesiol, Chiba, Japan.
   [Nishida, Tomoki] Shonan Kamakura Gen Hosp, Dept Gen Thorac Surg, Yokohama, Kanagawa, Japan.
   [Isogai, Jun] Asahi Gen Hosp, Dept Radiol, Asahi, Japan.
RP Yamamoto, H (通讯作者)，Narita Tomisato Tokushukai Hosp, Dept Cardiovasc Med, Chiba, Japan.
EM hyamamoto19700908@gmail.com
RI Yamamoto, Hiroyuki/O-7668-2019
OI Yamamoto, Hiroyuki/0000-0003-4742-7653
CR Agrafiotis AC, 2021, J THORAC DIS, V13, P4519, DOI 10.21037/jtd-21-208
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NR 28
TC 2
Z9 4
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD AUG 11
PY 2022
VL 9
AR 970239
DI 10.3389/fmed.2022.970239
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6Q6NG
UT WOS:000891728500001
PM 36035387
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Cook, SJ
   Nichols, FR
   Brunker, LB
   Bachus, KN
AF Cook, Saranne J.
   Nichols, Francesca R.
   Brunker, Lucille B.
   Bachus, Kent N.
TI A novel vacuum assisted closure therapy model for use with percutaneous
   devices
SO MEDICAL ENGINEERING & PHYSICS
LA English
DT Article
DE Animal model; Hairless rat; Negative-pressure wound therapy; Wound
   healing; Percutaneous device; Skin
ID PRESSURE WOUND THERAPY; MICROVASCULAR BLOOD-FLOW; OSSEOINTEGRATED
   PROSTHESES; HAIRLESS RAT; SKIN; IMPLANTS; INTERFACE; INFECTION; MOUSE
AB Long-term maintenance of a dermal barrier around a percutaneous prosthetic device remains a common clinical problem. A technique known as Negative Pressure Wound Therapy (NPWT) uses negative pressure to facilitate healing of impaired and complex soft tissue wounds. However, the combination of using negative pressure with percutaneous prosthetic devices has not been investigated. The goal of this study was to develop a methodology to apply negative pressure to the tissues surrounding a percutaneous device in an animal model; no tissue healing outcomes are presented. Specifically, four hairless rats received percutaneous porous coated titanium devices implanted on the dorsum and were bandaged with a semi occlusive film dressing. Two of these animals received NPWT; two animals received no NPWT and served as baseline controls. Over a 28-day period, both the number of dressing changes required between the two groups as well as the pressures were monitored. Negative pressures were successfully applied to the periprosthetic tissues in a clinically relevant range with a manageable number of dressing changes. This study provides a method for establishing, maintaining, and quantifying controlled negative pressures to the tissues surrounding percutaneous devices using a small animal model. Published by Elsevier Ltd on behalf of IPEM
C1 [Cook, Saranne J.; Nichols, Francesca R.; Bachus, Kent N.] Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, Salt Lake City, UT 84108 USA.
   [Cook, Saranne J.; Nichols, Francesca R.; Brunker, Lucille B.; Bachus, Kent N.] Dept Vet Affairs Med Ctr, Bone & Joint Res Lab, Salt Lake City, UT 84148 USA.
   [Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, 590 Wakara Way,Suite A100, Salt Lake City, UT 84108 USA.
EM kent.bachus@hsc.utah.edu
RI Bachus, Kent/KYO-7869-2024
OI Bachus, Kent/0000-0003-4435-6378
FU Department of Defense (BAA-10) [10091004]; Department of Orthopedics,
   University of Utah
FX The authors acknowledge funding from the Department of Defense (BAA-10
   (No. 10091004)). The Army Medical Research Acquisition Activity, 820
   Chandler Street, US Fort Detrick, MD 21702-5014 is the awarding and
   administering acquisition office. The content of the research does not
   necessarily reflect the position or the policy of the Government, and no
   official endorsement should be inferred. Funding is also provided in
   part by the Department of Orthopedics, University of Utah.
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NR 45
TC 2
Z9 2
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1350-4533
EI 1873-4030
J9 MED ENG PHYS
JI Med. Eng. Phys.
PD JUN
PY 2014
VL 36
IS 6
BP 768
EP 773
DI 10.1016/j.medengphy.2014.01.008
PG 6
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA AJ8CQ
UT WOS:000337930700017
PM 24685323
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ye, JN
   Xie, T
   Wu, MJ
   Ni, PW
   Lu, SL
AF Ye, Junna
   Xie, Ting
   Wu, Minjie
   Ni, Pengwen
   Lu, Shuliang
TI Negative Pressure Wound Therapy Applied Before and After Split-Thickness
   Skin Graft Helps Healing of Fournier Gangrene A Case Report
   (CARE-Compliant)
SO MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRIAL
AB Fournier gangrene is a rare but highly infectious disease characterized by fulminant necrotizing fasciitis involving the genital and perineal regions. Negative pressure wound therapy (NPWT; KCI USA Inc, San Antonio, TX) is a widely adopted technique in many clinical settings. Nevertheless, its application and effect in the treatment of Fournier gangrene are unclear.
   A 47-year-old male patient was admitted with an anal abscess followed by a spread of the infection to the scrotum, which was caused by Pseudomonas aeruginosa. NPWT was applied on the surface of the scrotal area and continued for 10 days. A split-thickness skin graft from the scalp was then grafted to the wound, after which, NPWT utilizing gauze sealed with an occlusive dressing and connected to a wall suction was employed for 7 days to secure the skin graft.
   At discharge, the percentage of the grafted skin alive on the scrotum was 98%. The wound beside the anus had decreased to 4 x 0.5 cm with a depth of 1 cm. Follow-up at the clinic 1 month later showed that both wounds had healed. The patient did not complain of any pain or bleeding, and was satisfied with the outcome.
   NPWT before and after split-thickness skin grafts is safe, well tolerated, and efficacious in the treatment of Fournier gangrene.
C1 [Ye, Junna; Lu, Shuliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Burns, Shanghai 200030, Peoples R China.
   [Xie, Ting; Wu, Minjie; Ni, Pengwen] Shanghai Jiao Tong Univ, Sch Med, Shanghai Hosp 9, Dept Wound Healing, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Lu, SL (通讯作者)，197 RuiJin 2nd Rd, Shanghai 200025, Peoples R China.
EM 13901738685@139.com
RI Ye, Junna/ABF-6141-2020
FU Shanghai Excellent Youth Teacher Cultivation Program; National Science
   and Technology Support Program of China [2012BAI11B04]
FX This work was supported by Shanghai Excellent Youth Teacher Cultivation
   Program and National Science and Technology Support Program of China
   (No. 2012BAI11B04).
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   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ozkan OF, 2015, INT WOUND J, V12, P364, DOI 10.1111/iwj.12103
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
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NR 16
TC 19
Z9 23
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2015
VL 94
IS 5
AR e426
DI 10.1097/MD.0000000000000426
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CA6DZ
UT WOS:000349000400004
PM 25654376
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Karam, RA
   Rezk, NA
   Rahman, TMA
   Al Saeed, M
AF Karam, Rehab A.
   Rezk, Noha A.
   Rahman, Tamer M. Abdel
   Al Saeed, Mohamed
TI Effect of negative pressure wound therapy on molecular markers in
   diabetic foot ulcers
SO GENE
LA English
DT Article
DE Diabetic foot ulcers: NPWT; Growth factors; Metalloproteinase
ID VACUUM-ASSISTED CLOSURE; MATRIX METALLOPROTEINASES; EXPRESSION; REPAIR;
   KERATINOCYTES; MECHANISMS; TRIAL; MMP-9; VEGF
AB Diabetic foot ulcers are one of the most common complications of diabetes with high morbidity and mortality. Negative pressure wound therapy (NPWT) is one of the treatment modalities that facilitates the wound healing process; however, its molecular mechanism remains unclear. The aim of this study was to investigate the mechanism of action of NPWT in the treatment of diabetic foot ulcers via measuring the tissue expression of genes related to the wound healing process. The study included 40 patients with diabetic foot ulceration, 20 of them received NPWT and the other 20 were a control group treated with advanced moist therapy. Granulation tissue biopsies were obtained before and 10 days after treatment in both groups and subjected to real-time polymerase chain reaction to measure the mRNA expression of TGF-beta 1, VEGF, TNF-alpha, IL-1 beta, MMP-1, MMP-9 and TIMP-1 which are involved in the wound healing pathway. After 10 days of treatment with NPWT, the mRNA levels of IL -1 beta, TNF-alpha, MMP-1, and MMP-9 were significantly downregulated, while the levels of VEGF, TGF-beta 1 and TIMP-1 were significantly increased. Our study demonstrated that NPWT promotes wound healing in diabetic foot ulcers possibly by affecting growth factors, inflammatory cytokines, and matrix metalloproteinases.
C1 [Karam, Rehab A.; Rezk, Noha A.] Zagazig Univ, Fac Med, Med Biochem Dept, Zagazig 44512, Egypt.
   [Karam, Rehab A.] Taif Univ, Biochem Dept, Fac Med, Al Taif, Saudi Arabia.
   [Rahman, Tamer M. Abdel] Gen Org Teaching Hosp & Inst, Cairo, Egypt.
   [Rahman, Tamer M. Abdel; Al Saeed, Mohamed] Taif Univ, Surg Dept, Coll Med, Al Taif, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Taif University;
   Egyptian Knowledge Bank (EKB); General Organization of Teaching
   Hospitals & Institutes (GOTHI); Taif University
RP Rezk, NA (通讯作者)，Zagazig Univ, Fac Med, Med Biochem Dept, Zagazig 44512, Egypt.
EM Narizk@zu.edu.eg
RI ; Ahmed Karam, Rehab/T-3604-2019
OI rezk, noha/0000-0002-5199-0134; Ahmed Karam, Rehab/0000-0001-9750-3218
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NR 44
TC 30
Z9 37
U1 1
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD AUG 15
PY 2018
VL 667
BP 56
EP 61
DI 10.1016/j.gene.2018.05.032
PG 6
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA GL1RK
UT WOS:000436884000007
PM 29758297
DA 2026-07-24
ER

PT J
AU Low, OW
   Chong, SJ
   Tan, BK
AF Low, O-Wern
   Chong, Si Jack
   Tan, Bien-Keem
TI The enhanced Total Body Wrap-The new frontier in dressing care for burns
SO BURNS
LA English
DT Article
DE Burns; Total Body Wrap; Vacuum assisted closure; Negative pressure wound
   therapy; Polyurethane dressing
ID IMPROVING GRAFT-SURVIVAL; ASSISTED CLOSURE DEVICE; SECURING SKIN-GRAFTS;
   SUBATMOSPHERIC PRESSURE; PROGRESSION
AB The management of extensive burns with their associated high fluid exudate following burn excision and skin grafting has always posed a challenge in burn wound care. The ideal dressing should protect the wound from physical damage and micro-organisms; be comfortable and durable; allow high humidity at the wound; and be able to allow maximal activity for wound healing without retarding or inhibiting any stage of the process.
   The dressing technique described in this paper fulfils all the criteria above and at the same time provides an efficient channel to effectively clear the excessive exudate produced while keeping the wounds moist. Advantages conferred include accurate charting of wound exudate; reduced frequency of dressing changes; lower infection rates through prevention of strike-through; and securing and improving the viability of skin grafts.
   An enhancement to a technique previously described by us through the use of long thin strips of VAC sponges to transmit negative pressure, the enhanced Total Body Wrap aims to provide ideal conditions to promote healing in burns. Using negative pressure wound therapy (NPWT), this technique is simple and straightforward enough to be applied in majority of tertiary centres around the world. (C) 2013 Published by Elsevier Ltd and ISBI.
C1 [Low, O-Wern; Chong, Si Jack; Tan, Bien-Keem] Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Singapore 169608, Singapore.
   [Chong, Si Jack] Navy Med Serv, Singapore, Singapore.
C3 Singapore General Hospital
RP Tan, BK (通讯作者)，Singapore Gen Hosp, Dept Plast Reconstruct & Aesthet Surg, Outram Rd, Singapore 169608, Singapore.
EM bienkeem@gmail.com
CR [Anonymous], OSTOMY WOUND MANAGEM
   Chong Si Jack, 2010, Burns, V36, pe127, DOI 10.1016/j.burns.2010.05.007
   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
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   Tominaga GT, 2002, ARCH SURG-CHICAGO, V137, P933
NR 6
TC 12
Z9 14
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD NOV
PY 2013
VL 39
IS 7
BP 1420
EP 1422
DI 10.1016/j.burns.2013.03.010
PG 3
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA 244BT
UT WOS:000326362800015
PM 23742730
DA 2026-07-24
ER

PT J
AU Neuhaus, K
   Meuli, M
   Koenigs, I
   Schiestl, C
AF Neuhaus, Kathrin
   Meuli, Martin
   Koenigs, Ingo
   Schiestl, Clemens
TI Management of "Difficult" Wounds
SO EUROPEAN JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE negative pressure wound therapy; wound healing; immunosuppression;
   child; pressure sore
ID VACUUM-ASSISTED CLOSURE; PRESSURE SORES; NUTRITION; THERAPY; ULCERS;
   FLAPS
AB Pressure sores (PSs) and wounds in immunocompromised children are rather rare conditions. No doubt, their management is often complex and difficult, even for experienced pediatric plastic surgeons. As there are no algorithms for standard care, the therapeutic approach is individual. Successful PS management always implies primary and secondary prevention. With a PS present, rapid relief of pressure is crucial. If local wound care fails to restore skin integrity within a short period of time, surgical defect closure is mandatory. Overall, full-thickness skin grafts and local flap surgery are the most suitable methods regarding result quality, procedure complexity, and risks. Negative pressure wound therapy (NPWT) plays an instrumental role in wound bed preparation before definitive coverage. Recurrence rate is high (the complication). It does not much depend on the surgical technique employed, but rather depends on whether the various pathogenic factors leading to PS can be eliminated or alleviated. In both temporarily and permanently immunocompromised children, wound healing is significantly impaired. At the same time, these patients have no or low host defense activity. Thus, they are at high risk not only for local wound infection but also for potentially life threatening septic complications. Rapid and definitive wound closure is therefore essential. When conservative therapy fails, simple surgical techniques granting rapid and definitive wound closure should be used.
C1 [Neuhaus, Kathrin; Meuli, Martin; Schiestl, Clemens] Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Recontruct Surg, Dept Surg, CH-8032 Zurich, Switzerland.
   [Koenigs, Ingo] Univ Med Ctr Eppendorf, Dept & Clin Paediat Surg, Hamburg, Germany.
   [Koenigs, Ingo] Altonas Children Hosp, Hamburg, Germany.
C3 University Children's Hospital Zurich; University of Hamburg; University
   Medical Center Hamburg-Eppendorf
RP Neuhaus, K (通讯作者)，Univ Childrens Hosp Zurich, Pediat Burn Ctr, Div Plast & Recontruct Surg, Dept Surg, Steinwiesstr 75, CH-8032 Zurich, Switzerland.
EM kathrin.neuhaus@kispi.uzh.ch
OI Neuhaus, Kathrin/0000-0003-2438-1779
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NR 41
TC 12
Z9 13
U1 0
U2 22
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0939-7248
EI 1439-359X
J9 EUR J PEDIATR SURG
JI Eur. J. Pediatr. Surg.
PD OCT
PY 2013
VL 23
IS 5
BP 365
EP 374
DI 10.1055/s-0033-1354588
PG 10
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA 220YO
UT WOS:000324623700005
PM 24008551
DA 2026-07-24
ER

PT J
AU Richter, S
   Dold, S
   Doberauer, JP
   Mai, P
   Schuld, J
AF Richter, Sven
   Dold, Stefan
   Doberauer, Johannes P.
   Mai, Peter
   Schuld, Jochen
TI Negative Pressure Wound Therapy for the Treatment of the Open Abdomen
   and Incidence of Enteral Fistulas: A Retrospective Bicentre Analysis
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID TEMPORARY ABDOMINAL CLOSURE; VACUUM-ASSISTED CLOSURE; PRIMARY FASCIAL
   CLOSURE; VENTRAL HERNIA; DAMAGE CONTROL; SILO CLOSURE; MANAGEMENT;
   PERITONITIS; EXPERIENCE; TRAUMA
AB Introduction. The open abdomen (OA) is often associated with complications. It has been hypothesized that negative pressure wound therapy (NPWT) in the treatment of OA may provoke enteral fistulas. Therefore, we analyzed patients with OA and NPWT with special regard to the occurrence of intestinal fistulas. Methods. The present study included all consecutive patients with OA treated with NWPT from April 2010 to August 2011 in two hospitals. Patients' demographics, indications for OA, risk factors, complications, outcome and incidence of fistulas before, during and after NPWT were recorded. Results. Of 81 patients with OA, 26 had pre-existing fistulas and 55 were free from a fistula at the beginning of NPWT. Nine of the 55 patients developed fistulas during (n = 5) or after NPWT (n = 4). Seventy-five patients received ABThera therapy, 6 patients other temporary abdominal closure devices. Only diverticulitis seemed to be a significant predisposing factor for fistulas. Mortality was slightly lower for patients without fistulas. Conclusion. The present study revealed no correlation between occurrence of fistulas before, during, and after NWPT, with diverticulitis being the only risk factor. Fistula formation during NPWT was comparable to reports from literature. Prospective studies are mandatory to clarify the impact of NPWT on fistula formation.
C1 [Richter, Sven] Furst Stirum Klin, Dept Gen Visceral & Vasc Surg, D-76646 Bruchsal, Germany.
   [Dold, Stefan; Schuld, Jochen] Univ Hosp Saarland, Dept Gen Visceral Vasc & Pediat Surg, D-66421 Homburg, Germany.
   [Doberauer, Johannes P.; Mai, Peter] Barmherzige Bruder Hosp, Dept Gen & Visceral Surg, D-80639 MUN Munich, Germany.
C3 Universitatsklinikum des Saarlandes
RP Schuld, J (通讯作者)，Univ Hosp Saarland, Dept Gen Visceral Vasc & Pediat Surg, D-66421 Homburg, Germany.
EM jochen.schuld@uks.eu
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NR 42
TC 22
Z9 26
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2013
VL 2013
AR 730829
DI 10.1155/2013/730829
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 249CB
UT WOS:000326753200001
PM 24285953
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, CK
   Alcantara, S
   Goss, S
   Lantis, JC
AF Yang, C. Kevin
   Alcantara, Sean
   Goss, Selena
   Lantis, John C., II
TI Cost analysis of negative-pressure wound therapy with instillation for
   wound bed preparation preceding split-thickness skin grafts for massive
   (&gt;100 cm2) chronic venous leg ulcers
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PATIENT
AB Objective: Massive (>= 100 cm(2)) venous leg ulcers (VLUs) demonstrate very low closure rates with standard compression therapy and are costly to manage. Negative-pressure wound therapy (NPWT), followed by a split-thickness skin graft (STSG), can be a cost-effective alternative to this standard care. We performed a cost analysis of these two treatments.
   Methods: A retrospective review was performed of 10 ulcers treated with surgical debridement, 7 days of inpatient NPWT with topical antiseptic instillation (NPWTi), and STSG, with 4 additional days of inpatient NPWT bolster over the graft. Independent medical cost estimators were used to compare the cost of this treatment protocol with standard outpatient compression therapy.
   Results: The average length of time ulcers were present before patients entered the study was 38 months (range, 3-120 months). Eight of 10 patients had complete VLU closure by 6 months after NPWTi with STSG. The 6-month costs of the proposed treatment protocol and standard twice-weekly compression therapy were estimated to be $27,000 and $28,000, respectively.
   Conclusions: NPWTi with STSG treatment is more effective for closure of massive VLUs at 6 months than that reported for standard compression therapy. Further, the cost of the proposed treatment protocol is comparable with standard compression therapy.
C1 [Lantis, John C., II] Mt Sinai St Lukes Hosp, New York, NY 10025 USA.
   [Lantis, John C., II] Mt Sinai Roosevelt Hosp, New York, NY 10025 USA.
C3 Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Mt Sinai St Lukes Hosp, 1090 Amsterdam Ave,Ste 7A, New York, NY 10025 USA.
EM jlantis@chpnet.org
FU KCI (San Antonio, Tex)
FX J. C. L. is a paid consultant for KCI (San Antonio, Tex).
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NR 29
TC 25
Z9 28
U1 0
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD APR
PY 2015
VL 61
IS 4
BP 995
EP 999
DI 10.1016/j.jvs.2014.11.076
PG 5
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA CE4BP
UT WOS:000351776100024
PM 25595397
OA Bronze
DA 2026-07-24
ER

PT J
AU Yusuf, E
   Jordan, X
   Clauss, M
   Borens, O
   Mäder, M
   Trampuz, A
AF Yusuf, Erlangga
   Jordan, Xavier
   Clauss, Martin
   Borens, Olivier
   Maeder, Mark
   Trampuz, Andrej
TI High bacterial load in negative pressure wound therapy (NPWT) foams used
   in the treatment of chronic wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BREAST IMPLANTS; JOINT INFECTION; SONICATION;
   DIAGNOSIS; CONTAMINATION; TRIAL
AB No earlier study has investigated the microbiology of negative pressure wound therapy (NPWT) foam using a standardized manner. The purpose of this study is to investigate the bacterial load and microbiological dynamics in NPWT foam removed from chronic wounds (>3 months). To determine the bacterial load, a standardized size of the removed NPWT foam was sonicated. The resulting sonication fluid was cultured, and the colony-forming units (CFU) of each species were enumerated. Sixty-eight foams from 17 patients (mean age 63 years, 71% males) were investigated. In 65 (97%) foams, 1 and in 37 (54%) 2 bacterial types were found. The bacterial load remained high during NPWT treatment, ranging from 10(4) to 10(6) CFU/ml. In three patients (27%), additional type of bacteria was found in subsequent foam cultures. The mean bacterial count +/- standard deviation was higher in polyvinyl alcohol foam (6.1 +/- 0.5 CFU/ml) than in polyurethane (5.5 +/- 0.8 CFU/ml) (p=0.02). The mean of log of sum of CFU/ml in foam from 125mmHg (5.5 +/- 0.8) was lower than in foam from 100mmHg pressure (5.9 +/- 0.5) (p=0.01). Concluding, bacterial load remains high in NPWT foam, and routine changing does not reduce the load.
C1 [Yusuf, Erlangga; Borens, Olivier] Univ Lausanne Hosp, Surg Sept Unit, Dept Surg & Anesthesiol, Lausanne, Switzerland.
   [Jordan, Xavier; Maeder, Mark] Ctr Paraplegia & Craniocerebral Injury REHAB, Basel, Switzerland.
   [Clauss, Martin] Kantonsspital Baselland, Clin Orthoped & Trauma Surg, Liestal, Switzerland.
   [Trampuz, Andrej] Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, D-10117 Berlin, Germany.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Kantonsspital Baselland; Free University of Berlin; Humboldt University
   of Berlin; Charite Universitatsmedizin Berlin
RP Trampuz, A (通讯作者)，Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, Charitepl 1, D-10117 Berlin, Germany.
EM andrej.trampuz@gmail.com
RI Trampuz, Andrej/K-9633-2013; Clauss, Martin/K-9981-2019; Yusuf,
   Erlangga/H-5166-2019
OI Clauss, Martin/0000-0002-1598-2209; Yusuf, Erlangga/0000-0003-4779-2191;
   Jordan, Xavier/0000-0003-3389-0057
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NR 24
TC 58
Z9 67
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP
PY 2013
VL 21
IS 5
BP 677
EP 681
DI 10.1111/wrr.12088
PG 5
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 210IQ
UT WOS:000323825300005
PM 23927079
DA 2026-07-24
ER

PT J
AU Sano, H
   Ichioka, S
AF Sano, Hitomi
   Ichioka, Shigeru
TI Involvement of nitric oxide in the wound bed microcirculatory change
   during negative pressure wound therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Blood flow; Intravital microscope; L-NAME; Mechanical stress
ID VACUUM-ASSISTED CLOSURE; SYNTHASE; PHOSPHORYLATION; ARTERY
AB This study investigated the role of nitric oxide (NO) in the mechanism of blood flow increase in the wound bed during negative pressure wound therapy (NPWT). We developed an improved experimental model that allowed visualisation of the wound bed microcirculation under NPWT. Wounds were created on the mouse ear, taking care to preserve the subdermal vascular plexus, because the wound bed microcirculation was visualised using an intravital microscope system. We investigated whether application of a NO synthase inhibitor (N-G-nitro-l-arginine methyl ester: L-NAME) might diminish the effect of the NPWT in increasing the wound blood flow. The experimental animals were divided into a negative pressure group (negative pressure of -125 mmHg applied to the wound for 5 minutes; n = 8), and a negative pressure plus L-NAME group (administration of L-NAME prior to application of the negative pressure; n = 8). In the negative pressure group, significant increase of blood flow was observed at 1 minute after the negative pressure application, which was sustained until 5 minutes. On the contrary, in the negative pressure plus L-NAME group, no significant changes were observed throughout the period of observation. These findings suggest that NO synthesis is involved in the wound bed microcirculatory change induced by NPWT.
C1 [Sano, Hitomi] Univ Tokyo, Grad Sch Med, Dept Surg Sci, Tokyo, Japan.
   [Ichioka, Shigeru] Saitama Med Univ, Dept Plast & Reconstruct Surg, Moroyama, Saitama 3500495, Japan.
C3 University of Tokyo; Saitama Medical University
RP Ichioka, S (通讯作者)，Saitama Med Univ, Dept Plast & Reconstruct Surg, 38 Morohongo, Moroyama, Saitama 3500495, Japan.
EM ichioka2006@yahoo.co.jp
FU Grants-in-Aid for Scientific Research [23592652] Funding Source: KAKEN
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NR 21
TC 6
Z9 8
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD AUG
PY 2015
VL 12
IS 4
BP 397
EP 401
DI 10.1111/iwj.12121
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CM2OI
UT WOS:000357520400004
PM 23834415
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Hyldig, N
   Birke-Sorensen, H
   Kruse, M
   Vinter, C
   Joergensen, JS
   Sorensen, JA
   Mogensen, O
   Lamont, RF
   Bille, C
AF Hyldig, N.
   Birke-Sorensen, H.
   Kruse, M.
   Vinter, C.
   Joergensen, J. S.
   Sorensen, J. A.
   Mogensen, O.
   Lamont, R. F.
   Bille, C.
TI Meta-analysis of negative-pressure wound therapy for closed surgical
   incisions
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK; SITE INFECTION; GUIDELINES;
   MANAGEMENT; PREVENTION; QUALITY; GAUZE
AB Background: Postoperative wound complications are common following surgical procedures. Negative-pressure wound therapy (NPWT) is well recognized for the management of open wounds and has been applied recently to closed surgical incisions. The evidence base to support this intervention is limited. The aim of this study was to assess whether NPWT reduces postoperative wound complications when applied to closed surgical incisions.
   Methods: This was a systematic review and meta-analysis of randomized clinical trials of NPWT compared with standard postoperative dressings on closed surgical incisions.
   Results: Ten studies met the inclusion criteria, reporting on 1311 incisions in 1089 patients. NPWT was associated with a significant reduction in wound infection (relative risk (RR) 054, 95 per cent c.i. 033 to 089) and seroma formation (RR 048, 027 to 084) compared with standard care. The reduction in wound dehiscence was not significant. The numbers needed to treat were three (seroma), 17 (dehiscence) and 25 (infection). Methodological heterogeneity across studies led to downgrading of the quality of evidence to moderate for infection and seroma, and low for dehiscence.
   Conclusion: Compared with standard postoperative dressings, NPWT significantly reduced the rate of wound infection and seroma when applied to closed surgical wounds. Heterogeneity between the included studies means that no general recommendations can be made yet.
C1 [Hyldig, N.; Sorensen, J. A.; Bille, C.] Univ Southern Denmark, Inst Clin Res, Res Unit Plast Surg, Dept Plast Surg,Odense Univ Hosp, Odense, Denmark.
   [Hyldig, N.; Vinter, C.; Joergensen, J. S.; Mogensen, O.; Lamont, R. F.] Univ Southern Denmark, Inst Clin Res, Res Unit Gynaecol & Obstet, Dept Gynaecol & Obstet,Odense Univ Hosp, Odense, Denmark.
   [Kruse, M.] Univ Southern Denmark, Ctr Hlth Econ Res COHERE, Odense, Denmark.
   [Birke-Sorensen, H.] Aarhus Univ Hosp, Inst Clin Med, DK-8000 Aarhus, Denmark.
   [Lamont, R. F.] UCL, Northwick Pk Inst, Div Surg, Med Res Campus, London, England.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Aarhus University; University of London; University College
   London
RP Hyldig, N (通讯作者)，Odense Univ Hosp, Kloevervaenget 10,10th Floor, DK-5000 Odense, Denmark.
EM nana.hyldig@rsyd.dk
RI Birke-Sørensen, Hanne/B-6733-2015; Sørensen, Jens Ahm/D-6279-2014;
   Hyldig, Nana/AAH-5220-2020; Mogensen, Ole/Q-1894-2015
OI Sørensen, Jens Ahm/0000-0003-4903-0094; Hyldig,
   Nana/0000-0001-6758-6294; jørgensen, jan stener/0000-0001-5222-2535;
   Vinter, Christina Anne/0000-0001-5084-6053; Mogensen,
   Ole/0000-0001-7655-9909
FU manufacturer Smith Nephew
FX The authors are currently conducting a RCT of iNPWT that is partly
   funded by the manufacturer Smith & Nephew. They received an unrestricted
   grant of 61 pound 093 (approximately (sic)87 000, exchange rate 30
   November 2015) and 500 PICO (TM) dressings free of charge.
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NR 45
TC 192
Z9 214
U1 0
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD APR
PY 2016
VL 103
IS 5
BP 477
EP 486
DI 10.1002/bjs.10084
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DH6PU
UT WOS:000372914100002
PM 26994715
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Song, YP
   Wang, L
   Yuan, BF
   Shen, HW
   Du, L
   Cai, JY
   Chen, HL
AF Song, Yi-Ping
   Wang, Lei
   Yuan, Bao-Fang
   Shen, Hong-Wu
   Du, Lin
   Cai, Ji-Yu
   Chen, Hong-Lin
TI Negative-pressure wound therapy forIII/IVpressure injuries: A
   meta-analysis
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED-TRIAL;
   PREVALENCE; EXPRESSION; MANAGEMENT; DRESSINGS; SYSTEM; DEVICE; COST
AB This meta-analysis was conducted to identify the potential benefits and the efficacy of negative-pressure wound therapy (NPWT) for III/IV pressure injuries (PIs) compared with standard wound care (SWC). Sixteen RCTs with 629 patients were included in our analysis. The methodological quality was assessed by the Cochrane Collaboration Tool. The outcomes included complete ulcer healing rate, wound healing time, pain score, the frequency of dressing change, hospitalization cost, the condition of the exudate, and the wound improvement. The percentage of healing rate was 61.45% for the NPWT group and 36.90% for SWC (95% CI: 1.32-1.70). There were significant differences in wound healing time (WMD = -16.47 days, 95% [CI (-22.36, - 10.59) days,P <= .001]). The pain score and hospitalization cost in NPWT was lower compared with SWC group (WMD = -2.39, 95% CI [-3.47, -1.30],P <= .001); (SMD = -2.55, 95% CI [-4.07, -1.03],P < .01). The frequency of dressing change in both NPWT groups was greatly reduced (SMD = -3.61, 95% [CI (-4.57, - 2.66) times,P <= .001]). Our meta-analysis indicated that NPWT was associated with greater improvements in improving PIs and shorting healing time for III/IV PIs. However, this conclusion needs to be confirmed by high-quality multicenter RCTs.
C1 [Song, Yi-Ping; Du, Lin; Cai, Ji-Yu] Nantong Univ, Sch Med, Nantong, Jiangsu, Peoples R China.
   [Wang, Lei] Third Peoples Hosp Nantong, Informat Dept, Nantong, Jiangsu, Peoples R China.
   [Yuan, Bao-Fang; Shen, Hong-Wu] Nantong Univ, Nursing Dept, Affiliated Hosp, Nantong, Jiangsu, Peoples R China.
   [Chen, Hong-Lin] Nantong Univ, Sch Publ Hlth, Nantong, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Chen, HL (通讯作者)，Nantong Univ, Sch Publ Hlth, Nantong, Jiangsu, Peoples R China.
EM honglinyjs@126.com
OI Chen, Hong-Lin/0000-0003-0147-6863
FU Social and People's Livelihood Technology in Nantong city-General
   Project [MS12019038]
FX Social and People's Livelihood Technology in Nantong city-General
   Project, Grant/Award Number: MS12019038
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NR 58
TC 32
Z9 38
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN
PY 2021
VL 29
IS 1
BP 20
EP 33
DI 10.1111/wrr.12863
EA OCT 2020
PG 14
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA PT3DV
UT WOS:000579127300001
PM 32989919
DA 2026-07-24
ER

PT J
AU Téot, L
   Guillot-Masanovic, M
   Miquel, P
   Truchetet, F
   Meaume, S
   Dompmartin, A
   Kerihuel, JC
   Trial, C
   Faure, C
AF Teot, Luc
   Guillot-Masanovic, Margot
   Miquel, Pierre
   Truchetet, Francois
   Meaume, Sylvie
   Dompmartin, Anne
   Kerihuel, Jean Charles
   Trial, Chloe
   Faure, Christine
TI Clinical impact of negative-pressure wound therapy: A 1,126-patient
   observational prospective study
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; END-POINTS;
   MULTICENTER; ULCER; EXPERIENCE
AB Negative-pressure wound therapy (NPWT) was developed in the early 1990s and reported in 1997 by Argenta and Morykwas. Ignored at first, this technique progressively came to be considered as an outstanding advancement in reconstructive surgery. Several randomized controlled studies produced evidence for the effect of NPWT on promotion of granulation tissue formation and prevention of tissue damage and amputation. However, no important longitudinal study has yet produced clinical and economic data on the consequences of integrating NPWT into practice in multiple institutions. This prospective, comparative longitudinal study of NPWT as a clinical-practice innovation was conducted in 1,126 patients between March 2006 and June 2009 in 30 university and nonuniversity public and private hospitals in France. NPWT was proposed in a nonrandomized fashion for various clinical indications, and the patients were divided into two groups, one using NPWT, the second using standard care. Efficacy criteria were spontaneous closure, closure after surgical coverage using skin grafts or flaps, or achievement of 40% wound area regression. The results, observed in a pragmatic but not randomized study, are suggestive of a favorable impact of NPWT in multiple clinical situations. The significance of differences between surgical patients who underwent NPWT and those who did not was unclear, as NPWT had already been adopted by most of the surgical wards.
C1 [Teot, Luc; Trial, Chloe] Montpellier Reg Univ Hosp, Dept Surg, Montpellier, France.
   [Guillot-Masanovic, Margot] La Reunion Reg Univ Hosp, Rehabil Unit, St Denis, Reunion, France.
   [Miquel, Pierre] Valenciennes Hosp, Dept Orthoped, Valenciennes, France.
   [Truchetet, Francois] Metz Thionville Reg Univ Hosp, Dept Dermatol, Thionville, France.
   [Meaume, Sylvie] Paris Rothschild APHP Univ Hosp, Dept Geriatr, Paris, France.
   [Dompmartin, Anne] Caen Reg Univ Hosp, Dept Dermatol, Caen, France.
   [Kerihuel, Jean Charles] Vertical Co, Paris, France.
   [Faure, Christine] Montpellier Reg Univ Hosp, Montpellier, France.
C3 Universite de Montpellier; CHU de Montpellier; CHU Reunion; CH de
   Valenciennes; CHR Metz-Thionville; Assistance Publique Hopitaux Paris
   (APHP); Sorbonne Universite; Hopital Universitaire Rothschild - APHP;
   CHU de Caen NORMANDIE; Universite de Montpellier; CHU de Montpellier
RP Téot, L (通讯作者)，Hop Lapeyronie, Montpellier Univ Hosp, Dept Surg, Wound Healing Unit, 371 Ave Doyen Giraud, F-34295 Montpellier 5, France.
EM l-teot@chu-montpellier.fr
RI Dompmartin, Anne/HNI-8166-2023
FU French Ministry of Health; Direction Generale de l'Offre de Soins under
   French Ministry of Health
FX The STIC-TPN study group was funded by the French Ministry of Health and
   mainly realized thanks to the participation of Alain-Charles Masquelet
   (AP-HP Avicenne), Beatrice Crickx (AP-HP Bichat), Clelia Debure (AP-HP
   HEGP-Broussais), Maurice Mimoun and Florent Bonnet (AP-HP Rothschild),
   Patrice Mertl and Catherine Lok (CHU Amiens), Sandrine Cairey-Remonnay
   and Brigitte Faivre (CHU Besancon), Jean-Claude Castede and Thierry
   Fabre (CHU Bordeaux), Fabrice Narducci (Centre Oscar Lambret Lille),
   Bernard Lelong (Institut Paoli Calmettes Marseille), Michel Pannier and
   Franck Duteille (CHU Nantes), Elisa Lebreton (CHU Nice), Jean-Louis
   Richard and Denyse Vannereau (CHU Nimes), Geraldine Perceau (CHU Reims),
   Astrid Wilk (CHU Strasbourg), Jean-Louis Grolleau (CHU Toulouse), and
   Matthieu Lebrun and Annie Vermersch (CH Valenciennes).r A special thanks
   to Sophie Pinson, CRA, and to Cecile Peignier, project nurse in the
   Montpellier University Hospital. This study was covered by a project
   grant from the Direction Generale de l'Offre de Soins under the French
   Ministry of Health.
CR [Anonymous], 2004, WOUNDS, p3S
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NR 21
TC 9
Z9 12
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2014
VL 22
IS 3
BP 341
EP 350
DI 10.1111/wrr.12179
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AI1QF
UT WOS:000336625600008
PM 24844333
DA 2026-07-24
ER

PT J
AU He, XF
   Hu, Y
   Ye, PH
   Huang, L
   Zhang, F
   Ruan, YP
AF He, Xianfeng
   Hu, Yong
   Ye, Penghan
   Huang, Lei
   Zhang, Feng
   Ruan, Yongping
TI The operative treatment of complex pilon fractures: A strategy of soft
   tissue control
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Negative pressure wound therapy; pilon fractures; soft tissue control;
   staged protocol
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; PRESSURE WOUND
   THERAPY; BLOOD-FLOW; NEGATIVE-PRESSURE; INTERNAL-FIXATION; TIBIAL
   PLAFOND; OPEN REDUCTION; MANAGEMENT
AB Background: Pilon fractures are challenging to manage because of the complexity of the injury pattern and the risk of significant complications. The soft tissue injury and handling of the soft tissue envelope are crucial in pilon fracture outcomes. The purpose of this study was to evaluate the early rate of complications using the strategy of "soft tissue control" for operative treatment of complex pilon fractures.
   Materials and Methods: 36 complex pilon fractures were treated with the "soft tissue control" strategy. Patients followed the standard staged protocol, anterolateral approach to the distal tibia, the "no-touch" technique and incisional negative pressure wound therapy for pilon fractures. Patients were examined clinically at 2-3 weeks and then 8 weeks for complications associated with the surgical technique.
   Results: All fractures were AO/OTA (Orthopaedic Trauma Association) type C fractures (61% C3, 22% C2 and 16% C1). Only one patient developed superficial infection and resolved with antibiotics and local wound care. None developed deep infection.
   Conclusions: The strategy of soft tissue control for treatment of pilon fractures resulted in relatively low incidence of early wound complications in patients with complex pilon fractures.
C1 [He, Xianfeng; Hu, Yong; Ye, Penghan; Huang, Lei; Zhang, Feng; Ruan, Yongping] Ningbo 6 Hosp, Dept Orthoped Surg, Ningbo 315040, Zhejiang, Peoples R China.
RP He, XF (通讯作者)，Ningbo 6 Hosp, Dept Orthoped Surg, East Zhongshan Rd 1059, Ningbo 315040, Zhejiang, Peoples R China.
EM hexianfeng120@163.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 25
TC 9
Z9 18
U1 0
U2 9
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD SEP-OCT
PY 2013
VL 47
IS 5
BP 487
EP 492
DI 10.4103/0019-5413.118205
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 231FJ
UT WOS:000325400200010
PM 24133309
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Ozkan, OF
   Koksal, N
   Altinli, E
   Celik, A
   Uzun, MA
   Cikman, O
   Akbas, A
   Ergun, E
   Kiraz, HA
   Karaayvaz, M
AF Ozkan, Omer F.
   Koksal, Neset
   Altinli, Ediz
   Celik, Atilla
   Uzun, Mehmet A.
   Cikman, Oztekin
   Akbas, Alpaslan
   Ergun, Ersin
   Kiraz, Hasan A.
   Karaayvaz, Muammer
TI Fournier's gangrene current approaches
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Flexi-Seal Faecal Management System; Fournier's gangrene; Negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; THERAPY
AB Fournier's gangrene is a rare but highlymortal infectious disease characterised by fulminant necrotising fasciitis involving the genital and perineal regions. The objective of this study is to analyse the demographics, clinical feature and treatment approaches as well as outcomes of Fournier's gangrene. Data were collected retrospectively from medical records and operative notes. Patient data were analysed by demographics, aetiological factors, clinical features, treatment approaches and outcomes. Twelve patients (five female and seven male) were enrolled in this study. The most common aetiology was perianal abscess (41.6%). Wound cultures showed a mixture of microorganisms in six (50%) patients. For faecal diversion, while colostomywas performed in six cases (50%), Flexi-Seal was used in two cases (16.6%). In four patients (33.4%), no faecal diversion was performed. Negative pressure wound therapy (NPWT) system was effective in the last four patients (33.4%). The mean hospitalisation period in patients who used NPWT was 18 days, while it was 20 days in the others. NPWT in Fournier's gangrene is a safe dressing method. It promotes granulation formation. Flexi-Seal faecal management is an alternative method to colostomy and provides protection from its associated complications. The combination of two devices (Flexi-Seal and NPWT) is an effective and comfortable method in the management of Fournier's gangrene in appropriate patients.
C1 [Ozkan, Omer F.; Cikman, Oztekin; Karaayvaz, Muammer] Canakkale Onsekiz Mart Univ, Fac Med, Dept Gen Surg, Canakale, Turkey.
   [Koksal, Neset] Kafkas Univ, Dept Gen Surg, Fac Med, Kars, Turkey.
   [Altinli, Ediz] Bilim Univ, Dept Gen Surg, Fac Med, Istanbul, Turkey.
   [Celik, Atilla] Bagcilar Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Uzun, Mehmet A.; Ergun, Ersin] Haydarpasa Numune Training & Res Hosp, Dept Gen Surg, Istanbul, Turkey.
   [Akbas, Alpaslan] Canakkale Onsekiz Mart Univ, Dept Urol, Fac Med, Canakkale, Turkey.
   [Kiraz, Hasan A.] Canakkale Onsekiz Mart Univ, Dept Anestesiol, Fac Med, Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; Kafkas University; Demiroglu Bilim
   University; Istanbul Bagcilar Training & Research Hospital; Istanbul
   Haydarpasa Sultan Abdulhamid Training & Research Hospital; Istanbul
   Haydarpasa Numune Training & Research Hospital; Canakkale Onsekiz Mart
   University; Canakkale Onsekiz Mart University
RP Ozkan, OF (通讯作者)，Canakkale 18 Mart Univ, Sch Med, Dept Gen Surg, Kepez, Canakkale, Turkey.
EM ozkanfomer@gmail.com
RI Akbas, Alpaslan/AAX-5617-2020; Uzun, Mehmet/AHD-3410-2022; Celik,
   Atilla/GQA-4443-2022
OI Akbas, Alpaslan/0000-0003-1470-5952; 
CR Altarac S, 2012, UROL INT, V88, P289, DOI 10.1159/000335507
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NR 19
TC 38
Z9 57
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 713
EP 716
DI 10.1111/iwj.12357
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600070
PM 25145578
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kairinos, N
   McKune, A
   Solomons, M
   Hudson, DA
   Kahn, D
AF Kairinos, Nicolas
   McKune, Andrew
   Solomons, Michael
   Hudson, Donald A.
   Kahn, Delawir
TI The flaws of laser Doppler in negative-pressure wound therapy research
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; ACTIVATION; RESPONSES
AB Recent studies, using modalities other than laser Doppler, have indicated that perfusion during negative-pressure wound therapy (NPWT) is reduced, contrary to world literature. The aim of the present study was to evaluate whether the measuring technique of the laser Doppler could be influenced by the compressive nature of NPWT dressings and whether this could explain the conflicting findings. A hypothesis that it may be possible for laser Doppler to record similar readings to those obtained during NPWT by merely compressing tissues manually was tested on 12 NPWT dressings, with each undergoing an alternating series of manual compressive forces and NPWT (-125mmHg). During the periods of NPWT (n=12), the mean perfusion recording increased in five experiments, reduced in six, and remained unchanged in one. During the period when manual pressure was applied (n=12), there was a mean increase in perfusion in six experiments and a reduction in six. The type of change in perfusion (increase or decrease) was the same for both NPWT and manual pressure in 10 of the 12 experiments. In conclusion, laser Doppler can incorrectly record increased perfusion when tissues are compressed, implying that it is flawed in the field of NPWT research as tissues are always compressed to some degree by the NPWT dressing.
C1 [Kairinos, Nicolas; Hudson, Donald A.] Univ Cape Town, Dept Plast Reconstruct & Maxillofacial Surg, ZA-7925 Cape Town, South Africa.
   [Kairinos, Nicolas; Hudson, Donald A.; Kahn, Delawir] Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
   [McKune, Andrew] Univ KwaZulu Natal, Dept Sports Sci, Durban, South Africa.
   [Solomons, Michael] Univ Cape Town, Dept Orthopaed Surg, Martin Singer Hand Unit, ZA-7925 Cape Town, South Africa.
   [Kahn, Delawir] Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Kwazulu
   Natal; University of Cape Town; University of Cape Town
RP Kairinos, N (通讯作者)，5 Pipit Lane,Century Dr, ZA-7441 Cape Town, South Africa.
EM nickykairinos@gmail.com
RI McKune, Andrew/AAM-3086-2020
OI McKune, Andrew/0000-0002-5479-1544
FU Department of Surgery, Groote Schuur Hospital; University of Cape Town
FX This study was supported by funding from the Department of Surgery,
   Groote Schuur Hospital and the University of Cape Town. We would like to
   acknowledge Professor Sandie Thomson and Dr. Damian Clark for granting
   us the use of their laser Doppler.
CR Borgquist O, 2010, OSTOMY WOUND MANAG, V56, P60
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   Willy C, 2006, ZBL CHIR, V131, pS50, DOI 10.1055/s-2006-921421
NR 30
TC 26
Z9 30
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY-JUN
PY 2014
VL 22
IS 3
BP 424
EP 429
DI 10.1111/wrr.12168
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AI1QF
UT WOS:000336625600017
PM 24844341
DA 2026-07-24
ER

PT J
AU Lenet, T
   Gilbert, RWD
   Abou-Khalil, J
   Balaa, FK
   Martel, G
   Brind'Amour, A
   Bertens, KA
AF Lenet, Tori
   Gilbert, Richard W. D.
   Abou-Khalil, Jad
   Balaa, Fady K.
   Martel, Guillaume
   Brind'Amour, Alexandre
   Bertens, Kimberly A.
TI The impact of prophylactic negative pressure wound therapy on surgical
   site infections in pancreatic resection: A systematic review and
   meta-analysis
SO HPB
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; HIGH-RISK; COMPLICATIONS; HEAD
AB Background: Surgical site infections (SSI) cause significant morbidity. Prophylactic negative pressure wound therapy (NPWT) may promote wound healing and decrease SSI. The objective is to evaluate the effect of prophylactic NPWT on SSI in patients undergoing pancreatectomy.
   Methods: Electronic databases were searched from inception until April 2022. Randomized controlled trials (RCTs) comparing prophylactic NPWT to standard dressings in patients undergoing pancreatectomy were included. The primary outcome was the risk of SSI. Secondary outcomes included the risk of superficial and deep SSI and organ space infection (OSI). Random effects models were used for meta-analysis.
   Results: Four single-centre RCTs including 309 patients were identified. Three studies were industry-sponsored, and two were at high risk of bias. There was no significant difference in the risk of SSI in patients receiving NPWT vs. control (14% vs. 21%, RR = 0.72, 95%CI = 0.32- 1.60, p = 0.42, I-2 = 53%). Likewise, there was no significant difference in the risk of superficial and deep SSI or OSI. No significant difference was found on subgroup analysis of patients at high risk of wound infection or on sensitivity analysis of studies at low risk of bias.
   Conclusion: Prophylactic NPWT does not significantly decrease the risk of SSI among patients undergoing pancreatectomy. Insufficient evidence exists to justify the routine use of NPWT.
C1 [Lenet, Tori; Gilbert, Richard W. D.; Abou-Khalil, Jad; Balaa, Fady K.; Martel, Guillaume; Bertens, Kimberly A.] Univ Ottawa, Ottawa Hosp, Dept Surg, Liver & Pancreas Surg Unit, Ottawa, ON, Canada.
   [Lenet, Tori; Martel, Guillaume; Bertens, Kimberly A.] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
   [Brind'Amour, Alexandre] Univ Laval, Dept Surg, CHU Quebec, Quebec City, PQ, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; Ottawa Hospital Research Institute; Laval University; Laval
   University Hospital
RP Bertens, KA (通讯作者)，Univ Ottawa, Ottawa Hosp, Dept Surg, Liver & Pancreas Surg Unit, Ottawa, ON, Canada.; Bertens, KA (通讯作者)，Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
EM kbertens@toh.ca
RI Brind'Amour, Alexandre/AAA-7957-2021; Martel, Guillaume/H-7356-2019
OI Brind'Amour, Alexandre/0000-0002-9607-6987; Gilbert,
   Richard/0000-0002-3319-0432; Lenet, Tori/0000-0002-6797-1931; 
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NR 34
TC 7
Z9 7
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1365-182X
EI 1477-2574
J9 HPB
JI HPB
PD DEC
PY 2022
VL 24
IS 12
BP 2035
EP 2044
DI 10.1016/j.hpb.2022.08.010
EA DEC 2022
PG 10
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 8F3VH
UT WOS:000919594000001
PM 36244906
DA 2026-07-24
ER

PT J
AU Petzina, R
   Hoffmann, J
   Navasardyan, A
   Malmsjö, M
   Stamm, C
   Unbehaun, A
   Hetzer, R
AF Petzina, Rainer
   Hoffmann, Julia
   Navasardyan, Artashes
   Malmsjo, Malin
   Stamm, Christof
   Unbehaun, Axel
   Hetzer, Roland
TI Negative pressure wound therapy for post-sternotomy mediastinitis
   reduces mortality rate and sternal re-infection rate compared to
   conventional treatment
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 23rd Annual Techno-College Meeting of the
   European-Association-for-Cardio-Thoracic-Surgery (EACTS)
CY OCT 17-21, 2009
CL Vienna, AUSTRIA
SP European Assoc Cardio Thorac Surg (EACTS)
DE Mediastinal infection; Wound healing; Cardiac surgery
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; CARDIAC-SURGERY; INFECTION;
   COMPLICATIONS; SURVIVAL
AB Objective: Negative pressure wound therapy (NPWT) is a recently introduced treatment modality for post-sternotomy mediastinitis. The aim of this study was to compare the mortality rate, the sternal re-infection rate and the length of hospital stay in patients with post-sternotomy mediastinitis after NPWT and conventional treatment. Methods: We retrospectively analysed 118 patients with post-sternotomy mediastinitis after cardiac surgery. One group of 69 patients was treated with NPWT and the other group of 49 patients with conventional therapy. Results: There were no major differences between the two groups concerning preoperative data (EuroScore) or primary cardiac surgery (mainly coronary artery bypass grafting). NPWT therapy was found to reduce mortality rate (P = 0.005) and sternal re-infection rate (P = 0.008) compared with conventional treatment and tended to lead to a shorter length of hospital stay (P = 0.08). Conclusions: NPWT for post-sternotomy mediastinitis demonstrates encouraging clinical results with a reduction of the mortality rate and the sternal re-infection rate compared with conventional treatment. The results support NPWT as the first-line treatment for deep sternal wound infections. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
C1 [Petzina, Rainer; Hoffmann, Julia; Navasardyan, Artashes; Stamm, Christof; Unbehaun, Axel; Hetzer, Roland] Deutsch Herzzentrum Berlin, D-13353 Berlin, Germany.
   [Malmsjo, Malin] Univ Lund Hosp, S-22185 Lund, Sweden.
C3 German Heart Center Berlin; Lund University; Skane University Hospital
RP Petzina, R (通讯作者)，Deutsch Herzzentrum Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM petzina@dhzb.de
RI ; Unbehaun, Axel/IYS-3471-2023; Stamm, Christof/J-5719-2014
OI Maljö, Malin/0000-0001-9849-9599; Petzina, Rainer/0000-0002-0688-5482;
   Unbehaun, Axel/0000-0003-2851-695X; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Cowan KN, 2005, ANN THORAC SURG, V80, P2205, DOI 10.1016/j.athoracsur.2005.04.005
   Doss M, 2002, EUR J CARDIO-THORAC, V22, P934, DOI 10.1016/S1010-7940(02)00594-8
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Fleischmann W, 1996, UNFALLCHIRURG, V99, P283
   JURKIEWICZ MJ, 1980, ANN SURG, V191, P738, DOI 10.1097/00000658-198006000-00012
   Kadohama T, 2008, ANN THORAC SURG, V85, P1094, DOI 10.1016/j.athoracsur.2007.09.004
   LEE AB, 1976, SURGERY, V80, P433
   Lu JCY, 2003, EUR J CARDIO-THORAC, V23, P943, DOI 10.1016/S1010-7940(03)00137-4
   Mokhtari A, 2008, SCAND CARDIOVASC J, V42, P85, DOI 10.1080/14017430701744469
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Petzina R, 2006, EUR J CARDIO-THORAC, V30, P85, DOI 10.1016/j.ejcts.2006.04.009
   Ridderstolpe L, 2001, EUR J CARDIO-THORAC, V20, P1168, DOI 10.1016/S1010-7940(01)00991-5
   SHUMACKER HB, 1963, ARCH SURG-CHICAGO, V86, P384
   Sjögren J, 2005, ANN THORAC SURG, V80, P1270, DOI 10.1016/j.athoracsur.2005.04.010
   Stahle E, 1997, EUR J CARDIO-THORAC, V11, P1146, DOI 10.1016/S1010-7940(97)01210-4
   Wetzel-Roth W, 2004, ZBL CHIR, V129, pS7, DOI 10.1055/s-2004-822677
NR 18
TC 65
Z9 82
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD JUL
PY 2010
VL 38
IS 1
BP 110
EP 113
DI 10.1016/j.ejcts.2010.01.028
PG 4
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 623ML
UT WOS:000279744400020
PM 20171898
OA Bronze
DA 2026-07-24
ER

PT J
AU Ruiz-López, M
   Campos, JC
   Pérez, BS
   Sánchez, AG
   Aguilar, JLF
   Navarro, JAB
AF Ruiz-Lopez, Manuel
   Carrasco Campos, Joaquin
   Sanchez Perez, Belinda
   Gonzalez Sanchez, Antonio
   Fernandez Aguilar, Jose Luis
   Bondia Navarro, Jose Antonio
TI Negative pressure therapy in wounds with enteric fistulas
SO CIRUGIA ESPANOLA
LA Spanish
DT Article
DE Enterocutaneous fistulas; Wounds; Negative-pressure wound therapy
ID VACUUM-ASSISTED CLOSURE
AB Objective: Negative pressure therapy (VAC, vacuum assisted closure) is a method used still in our country. It consists of a system of aspirating a wound by means of a piece of foam and a few adhesive films. It allows the treatment of complex wounds, included (although this is still controversial) those with intestinal fistulas. We present 3 cases of treatment with VAC in this situation and a review of the published literature.
   Patients and method: We have treated 10 patients, since VAC therapy was introduced into our centre of which 3 of whom had a fistula in the bed of the surgical wound. We describe the clinical information of the patients and the therapy that followed in each of the cases.
   Results: Significant local clinical improvement of the disease, with control of the symptoms, was achieved in all 3 cases. We were able to re-operate to close the fistula in one of the patients, with subsequent good progression of the wound. In the other two cases it gave them a better quality of life although both died due to the overall complexity of their situation.
   Conclusions: VAC therapy, although controversial in the treatment of intestinal fistulas, can help to improve the local situation of the wounds, the comfort of the patients and their general situation. (c) 2008 AEC. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Ruiz-Lopez, Manuel; Carrasco Campos, Joaquin; Sanchez Perez, Belinda; Gonzalez Sanchez, Antonio; Fernandez Aguilar, Jose Luis; Bondia Navarro, Jose Antonio] Hosp Reg Carlos Haya, Serv Cirugia Gen & Digest, Malaga, Spain.
C3 Hospital Regional Universitario de Malaga
RP Ruiz-López, M (通讯作者)，Hosp Reg Carlos Haya, Serv Cirugia Gen & Digest, Malaga, Spain.
EM man.rui@terra.es
OI Fernández Aguilar, Jose luis/0009-0003-1304-6809; Sánchez,
   Belinda/0000-0003-1659-5427
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Fischer JE, 2008, AM J SURG, V196, P1, DOI 10.1016/j.amjsurg.2008.01.001
   Fleischmann W, 1992, Acta Orthop Belg, V58 Suppl 1, P227
   Gregor S, 2008, ARCH SURG-CHICAGO, V143, P189, DOI 10.1001/archsurg.2007.54
   Joseph E, 2000, WOUNDS, V12, P60
   Lambert KV, 2005, EUR J VASC ENDOVASC, V29, P219, DOI 10.1016/j.ejvs.2004.12.017
   Nienhuijs S W, 2003, J Wound Care, V12, P343
   Rao M, 2007, COLORECTAL DIS, V9, P266, DOI 10.1111/j.1463-1318.2006.01154.x
   Venturi ML, 2005, AM J CLIN DERMATOL, V6, P185, DOI 10.2165/00128071-200506030-00005
NR 9
TC 8
Z9 12
U1 0
U2 1
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD JUL
PY 2009
VL 86
IS 1
BP 29
EP 32
DI 10.1016/j.ciresp.2009.01.029
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 468DZ
UT WOS:000267796300006
PM 19486962
DA 2026-07-24
ER

PT J
AU Fukuzaki, H
   Nakata, J
   Nojiri, S
   Shimizu, Y
   Kano, T
   Shirotani, Y
   Maeda, T
   Nohara, N
   Io, H
   Suzuki, Y
AF Fukuzaki, Haruna
   Nakata, Junichiro
   Nojiri, Shuko
   Shimizu, Yuki
   Kano, Toshiki
   Shirotani, Yuka
   Maeda, Takuya
   Nohara, Nao
   Io, Hiroaki
   Suzuki, Yusuke
TI Negative-pressure wound therapy is effective for peritoneal dialysis
   catheter exit-site management in the early postoperative period
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; BED PREPARATION; SCORING SYSTEM; INFECTION
AB Peritoneal dialysis (PD) catheter exit-site care is critically important for the prevention of catheterrelated infections (CRIs) and subsequent peritonitis. The postoperative management of the site is particularly essential because it has an open wound that is always adjacent to a PD catheter tube. This study aimed to examine the effectiveness of negative-pressure wound therapy (NPWT) for postoperative PD catheter exit sites. Thirty patients with end-stage renal disease who underwent simultaneous PD catheter insertion and exit-site formation were randomly assigned to receive NPWT (NPWT group) or conventional dressing (non-NPWT group) for the first seven postoperative days. The exit-site scores on the seventh postoperative day was lower in the NPWT group than in the non-NPWT group (p = 0.0049). Analysis of variance F statistic for the effect of NPWT over 180 days was highly significant (11.482595, p = 0.007). There were no statistically significant differences between the time to first CRI and PD-related peritonitis between the two groups. There was one case of CRI with relapsing peritonitis and catheter loss in the non-NPWT group. These findings demonstrate the association between NPWT and low exit-site score. NPWT can be recommended for the management of PD catheter exit sites in the early postoperative period.
C1 [Fukuzaki, Haruna; Nakata, Junichiro; Shimizu, Yuki; Kano, Toshiki; Shirotani, Yuka; Maeda, Takuya; Nohara, Nao; Suzuki, Yusuke] Juntendo Univ, Dept Nephrol, Fac Med, Tokyo, Japan.
   [Nojiri, Shuko] Juntendo Univ, Med Technol Innovat Ctr, Tokyo, Japan.
   [Kano, Toshiki; Io, Hiroaki] Juntendo Univ, Dept Nephrol, Nerima Hosp, Tokyo, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Suzuki, Y (通讯作者)，Juntendo Univ, Dept Nephrol, Fac Med, Tokyo, Japan.
EM yusuke@juntendo.ac.jp
RI ; IO, Hiroaki/AGG-5274-2022
OI Shimizu, Yuki/0000-0002-6729-7414; 
FU Japan Society for the Promotion of Science [JP21K11199]
FX This study was partially supported by a Grant-in-Aid for Scientific
   Research (KAKENHI) from the Japan Society for the Promotion of Science
   grants JP21K11199 (to J. Nakata).
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NR 32
TC 2
Z9 3
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 7
PY 2022
VL 12
IS 1
AR 70
DI 10.1038/s41598-021-03878-5
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YD5VU
UT WOS:000740510500079
PM 34996968
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hutton, DW
   Sheehan, P
AF Hutton, David W.
   Sheehan, Peter
TI Comparative effectiveness of the SNaP™ Wound Care System
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Cost and cost analysis; Diabetic foot ulcers; Negative pressure wound
   therapy; SNaP system; Wound care
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; THERAPY; MULTICENTER; DRESSINGS; COSTS
AB Diabetic lower extremity wounds cause substantial burden to healthcare systems, costing tens of thousands of dollars per episode. Negative pressure wound therapy (NPWT) devices have been shown to be cost-effective at treating these wounds, but the traditional devices use bulky electrical pumps that require a durable medical equipment rental-based procurement process. The Spiracur SNaP (TM) Wound Care System is an ultraportable NPWT system that does not use an electric pump and is fully disposable. It has superior healing compared to standard of care with modern dressings and comparable healing to traditional NPWT devices while giving patients greater mobility and giving clinicians a simpler procurement process. We used a mathematical model to analyse the costs of the SNaP (TM) system and compare them to standard of care and electrically powered NPWT devices. When compared to standard of care, the SNaP (TM) system saves over $9000 per wound treated and more than doubles the number of patients healed. The SNaP system has similar healing time to powered NPWT devices, but saves $2300 in Medicare payments or $2800 for private payers per wound treated. Our analysis shows that the SNaP (TM) system could save substantial treatment costs in addition to allowing patients greater freedom and mobility.
C1 [Hutton, David W.] Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA.
   [Sheehan, Peter] Sheehan Hlth Management Consulting, New York, NY USA.
C3 University of Michigan System; University of Michigan
RP Hutton, DW (通讯作者)，Univ Michigan, Sch Publ Hlth, Dept Hlth Management & Policy, Ann Arbor, MI 48109 USA.
EM dwhutton@umich.edu
OI Hutton, David/0000-0001-9677-1632
FU Spiracur, Inc.
FX DH has received sponsorship of this research from Spiracur, Inc. PS is a
   consultant for Spiracur.
CR [Anonymous], 2009, RED BOOK PHARM FUND
   Apelqvist J, 2008, AM J SURG, V195, P782, DOI 10.1016/j.amjsurg.2007.06.023
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   2009, FED REG         1110, V74, P58078
   VAC THERAPY EC VALUE
   SNAP WOUND CARE SYST
NR 33
TC 12
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2011
VL 8
IS 2
BP 196
EP 205
DI 10.1111/j.1742-481X.2011.00775.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 735YW
UT WOS:000288457700015
PM 21385320
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Fong, KD
   Hu, D
   Eichstadt, SL
   Gorell, E
   Munoz, CA
   Lorenz, HP
   Chang, ALS
AF Fong, Kenton D.
   Hu, Dean
   Eichstadt, Shaundra L.
   Gorell, Emily
   Munoz, Claudia A.
   Lorenz, H. Peter
   Chang, Anne Lynn S.
TI Initial Clinical Experience Using a Novel Ultraportable Negative
   Pressure Wound Therapy Device
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; ULCERS; STATE;
   MULTICENTER; ART
AB Background. Traditional negative pressure wound therapy (NPWT) devices, such as the electrically powered V.A.C.(R) Therapy System (KCI, San Antonio, TX), are important tools in the treatment of both acute and chronic wounds. The following describes the first clinical experience using a novel, non-electrically powered, ultraportable NPWT device called the Smart Negative Pressure (SNaP (TM)) Wound Care System (Spiracur, Sunnyvale, CA). Methods. Twelve consecutive adult subjects with chronic wounds ranging from neuropathic wounds to venous stasis ulcers were treated with the SNaP System at an academic outpatient dermatology clinic. Subjects were followed biweekly for complications and wound healing progression over a 4-week period. Results. Of the 12 subjects treated, 5 achieved complete wound healing within 4 weeks. All subjects demonstrated healing after treatment with the SNaP System, and statistically significant healing was reached at 4 weeks (P < 0.01) for patients who were able to complete the treatment protocol. Use of the SNaP System promoted cleaner wound beds with robust granulation tissue formation. There were no serious adverse events directly related to the device. The most common complaint was mild or moderate wound pain in 3 of 12 subjects. Conclusion. These findings support the safety and potential clinical utility of a new ultraportable NPWT device for the treatment of chronic wounds.
C1 [Gorell, Emily; Munoz, Claudia A.; Chang, Anne Lynn S.] Stanford Univ, Sch Med, Dept Dermatol, Stanford, CA 94305 USA.
   [Hu, Dean] Stanford Univ, Dept Biomed Engn, Stanford, CA 94305 USA.
   [Fong, Kenton D.; Hu, Dean] Spiracur Inc, Sunnyvale, CA USA.
   [Fong, Kenton D.; Eichstadt, Shaundra L.; Lorenz, H. Peter] Stanford Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University; Stanford University
RP Chang, ALS (通讯作者)，Stanford Univ, Sch Med, Dept Dermatol, 450 Broadway,Pavil C, Redwood City, CA 94063 USA.
EM alschang@stanford.edu
RI ; Gorell, Emily/AAF-4966-2021
OI Chang, Anne Lynn/0000-0002-2869-2147; Gorell, Emily/0000-0002-2813-3089
FU Spiracur TradeMark Inc.
FX This work was supported by a research grant from Spiracur (TM) Inc.
CR Abbade LPF, 2005, INT J DERMATOL, V44, P989, DOI 10.1111/j.1365-4632.2004.02276.x
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Blume PA, 2008, DIABETES CARE, V31, P631, DOI 10.2337/dc07-2196
   Campbell PE, 2006, J WOUND OSTOMY CONT, V33, P176, DOI 10.1097/00152192-200603000-00014
   Campbell PE, 2008, INT WOUND J, V5, P280, DOI 10.1111/j.1742-481X.2008.00485.x
   Keskin M, 2008, SCAND J PLAST RECONS, V42, P202, DOI 10.1080/02844310802091586
   Leijnen M, 2007, J Wound Care, V16, P211
   Lerman B, PLAST RECON IN PRESS
   Malli Suzanne, KEEP CLOSE EYE VACUU
   Morykwas MJ, 2006, PLAST RECONSTR SURG, V117, p121S, DOI 10.1097/01.prs.0000225450.12593.12
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   Reichenberg J, 2005, SEMIN CUTAN MED SURG, V24, P216, DOI 10.1016/j.sder.2005.10.002
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   US Food & Drug Administration, ADV PAT SER COMPL NE
   Vuerstaek JDD, 2006, J VASC SURG, V44, P1029, DOI 10.1016/j.jvs.2006.07.030
NR 17
TC 13
Z9 16
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2010
VL 22
IS 9
BP 230
EP 236
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 697QZ
UT WOS:000285531700007
PM 25901554
DA 2026-07-24
ER

PT J
AU Schlatterer, D
   Hirshorn, K
AF Schlatterer, Daniel
   Hirshorn, Kurt
TI Negative Pressure Wound Therapy With Reticulated Open Cell
   Foam-Adjunctive Treatment in the Management of Traumatic Wounds of the
   Leg: A Review of the Literature
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Review
DE NPWT/ROCF; infection; skin graft; dermal grafts; muscle flap; VAC; VAC
   Therapy
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; SECURING SKIN-GRAFTS;
   TIBIAL SHAFT FRACTURES; FLAP DONOR-SITE; IN-VITRO MODEL; SUBATMOSPHERIC
   PRESSURE; CHRONIC OSTEOMYELITIS; VAC(TM) INSTILLATION;
   CLINICAL-EXPERIENCE
AB Over the last decade, the application of and indications for negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by VA.C.(R) Therapy (KCI, San Antonio, TX) have grown tremendously. This is particularly true in orthopaedic trauma in the management of injuries to the leg, ankle, and foot. This article reviews the evidence-based medicine in terms of NPWT/ROCF, as a method of reducing bacterial counts in wounds, as a bridge until definitive bony coverage, for treating infections, and as ail adjunct to Wound bed preparation and for bolstering split-thickness skin grafts, dermal replacement grafts, and over muscle flaps. NPWT/ROCF has been shown to be ail adjunct to the mainstays of wound management. No significant complications have been noted in the categories of NPWT/ROCF discussed in this reviews In addition, evidence Supports a decrease in complex soft tissue procedures in grade IIIB open fractures when NPWT/ROCF is employed. Although more research needs to be done, NPWT/ROCF appears to provide clinical benefit for the treatment of these complex lower extremity wounds.
C1 [Schlatterer, Daniel; Hirshorn, Kurt] Atlanta Med Ctr, Dept Orthoped Surg, Atlanta, GA 30312 USA.
C3 WellStar Atlanta Medical Center
RP Schlatterer, D (通讯作者)，Atlanta Med Ctr, Dept Orthoped Surg, 303 Pkwy Dr NE, Atlanta, GA 30312 USA.
EM daniel.schlatterer@tenethealth.com
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NR 43
TC 23
Z9 29
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD NOV-DEC
PY 2008
VL 22
IS 10
SU S
BP S152
EP S160
DI 10.1097/BOT.0b013e318188e2d7
PG 9
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 371GP
UT WOS:000260820100007
PM 19034163
DA 2026-07-24
ER

PT J
AU Chen, CY
   Chiang, IH
   Ou, KL
   Chiu, YL
   Liu, HH
   Chang, CK
   Wu, CJ
   Chu, TS
   Hsu, KF
   Huang, DW
   Tzeng, YS
AF Chen, Chun-Yu
   Chiang, I-Han
   Ou, Kuang-Ling
   Chiu, Yu-Lung
   Liu, Hung-Hui
   Chang, Chun-Kai
   Wu, Chien-Ju
   Chu, Tzi-Shiang
   Hsu, Kuo-Feng
   Huang, Dun-Wei
   Tzeng, Yuan-Sheng
TI Surgical treatment and strategy in patients with pressure sores A
   single-surgeon experience
SO MEDICINE
LA English
DT Article
DE surgical flaps; pressure sore; indocyanine green; negative-pressure
   wound therapy; vacuum-assisted closure
ID ARTERY PERFORATOR FLAP; RECONSTRUCTION; COVERAGE; ULCERS
AB With aging, pressure ulcers become a common health problem causing significant morbidity and mortality for physically limited or bedridden elderly persons. Here, we present our strategy for such patients. Between August 2010 and March 2019, 117 patients were enrolled. Patient age, etiology, defect size and location, flap reconstruction, outcome, and follow-up period were reviewed. Of these patients, 64 were female and 53 were male, with an age range of 21 to 96 years (mean 75.6). The mean area of defect was 61.5 cm(2). The most common etiology was dementia (33.3%), and ulcers were most frequently caused by sacral pressure (70.3%). The commonest surgical treatment was a V-Y advancement flap (50%). The complication rate was 27.5%, including dehiscence and late recurrence. Negative pressure wound therapy could be used if the initial defect was large. V-Y advancement flap is the most frequent surgical treatment for sacral pressure ulcers because it is simple and available for most types of defect. Primary closure may be considered as the simplest method if the defective area is <16 cm(2). Intraoperative indocyanine green angiography can help avoid secondary flap revisions. Our protocol ensures a short surgery time, little bleeding, and a low complication rate.
C1 [Chen, Chun-Yu; Chiang, I-Han; Ou, Kuang-Ling; Liu, Hung-Hui; Chang, Chun-Kai; Wu, Chien-Ju; Chu, Tzi-Shiang; Hsu, Kuo-Feng; Huang, Dun-Wei; Tzeng, Yuan-Sheng] Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, Natl Def Med Ctr, Taipei, Taiwan.
   [Chen, Chun-Yu] Taoyuan Armed Forces Gen Hosp, Dept Surg, Taoyuan, Taiwan.
   [Chiu, Yu-Lung] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Chiu, Yu-Lung] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical University;
   National Defense Medical University; National Defense Medical University
RP Tzeng, YS (通讯作者)，Triserv Gen Hosp, Div Plast & Reconstruct Surg, Dept Surg, 325,Sec 2,Cheng Gong Rd, Taipei 114, Taiwan.
EM m6246kimo@yahoo.com.tw
RI ; Tzeng, Yuan-sheng/AAD-8843-2020
OI Huang, Dun-Wei/0000-0002-5320-2517; 
FU Ministry of Science and Technology, Taiwan, ROC [MOST
   108-2314-B-016-041]; Tri-Service General Hospital, Taiwan, ROC
   [TSGH-C107-117]
FX This study was supported by a grant, MOST 108-2314-B-016-041, from the
   Ministry of Science and Technology, TSGH-C107-117 from Tri-Service
   General Hospital, Taiwan, ROC.
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NR 14
TC 16
Z9 20
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 30
PY 2020
VL 99
IS 44
AR e23022
DI 10.1097/MD.0000000000023022
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OP6HX
UT WOS:000588186500090
PM 33126386
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Greeny, A
   Shenoy, RR
AF Greeny, Alosh
   Shenoy, Rekha R.
TI Advances in Burn Wound Management: Innovative Strategies for Healing and
   Infection Control
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
DE nanotherapeutics; hydrogels; stem cell therapy; negative pressure wound
   therapy; burn wound; acellular fish skin
ID VACUUM-ASSISTED CLOSURE; MESENCHYMAL STEM-CELLS; FISH-SKIN-GRAFT; SILVER
   SULFADIAZINE; DRUG-DELIVERY; KELOID FIBROBLASTS; POLYVINYL-ALCOHOL;
   PRESSURE THERAPY; EDEMA FORMATION; HEALTH-CARE
AB Burn wounds are insults to the skin that can be caused by various sources, including thermal, electrical, or chemical sources, and even natural sources such as the sun. A burn wound is conventionally categorized into 3 distinct zones: (1) coagulation, (2) ischemia/stasis, and (3) hyperemia. In addition to the potential for physiological scarring, burn wounds can lead to microbial infections, such as pneumonia and methicillin-resistant Staphylococcus aureus, that are difficult to treat using conventional antimicrobial therapy. Patients whose burn wounds trigger a systemic inflammatory response experience further deterioration of their medical condition. Moreover, an increase in the incidence of antibiotic resistance poses a major challenge in the treatment of wounds. Researchers are shifting their focus to newer techniques, such as acellular fish skin, hydrogels, negative pressure wound therapy, nanotherapeutics, and stem cell therapy to counter the disadvantages associated with conventional therapy. This review provides an overview of burn wound causes, classifications, and treatments, and it discusses the healing phases of wounds, possible types of infections, the complexities associated with existing conventional treatments, and the advanced techniques currently used in burn wound management that have proven to reduce hospital stays and make treatment more cost-effective.
C1 [Greeny, Alosh; Shenoy, Rekha R.] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
C3 Manipal Academy of Higher Education (MAHE)
RP Shenoy, RR (通讯作者)，Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
EM rekha.shenoy@manipal.edu
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NR 147
TC 6
Z9 6
U1 5
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2025
VL 37
IS 5
BP 198
EP 209
DI 10.25270/wnds/24030
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 3YC6O
UT WOS:001511774400004
PM 40512682
DA 2026-07-24
ER

PT J
AU Losi, P
   Briganti, E
   Costa, M
   Sanguinetti, E
   Soldani, G
AF Losi, Paola
   Briganti, Enrica
   Costa, Manolo
   Sanguinetti, Elena
   Soldani, Giorgio
TI Silicone-coated non-woven polyester dressing enhances
   reepithelialisation in a sheep model of dermal wounds
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; EVOLUTION
AB Negative-pressure wound therapy (NPWT) also known as V.A.C. (Vacuum-assisted closure), is widely used to manage various type of wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane (PU) foam or medical gauze. In this study an experimental setup of sheep wound model was used to evaluate, under NPWT conditions, the performance of a silicone-coated non-woven polyester (N-WPE) compared with PU foam and cotton hydrophilic gauze, used as reference materials. Animals were anesthetized with spontaneous breathing to create three 3 x 3 cm skin defects bilaterally; each animal received three different samples on each side (n = 6 in each experimental group) and was subjected to negative and continuous 125 mmHg pressure up to 16 days. Wound conditions after 1, 8 and 16 days of treatment with the wound dressings were evaluated based on gross and histological appearances. Skin defects treated with the silicone-coated N-WPE showed a significant decrease in wound size, an increase of re-epithelialization, collagen deposition and wound neovascularisation, and a minimal stickiness to the wound tissue, in comparison with gauze and PU foam. Taken all together these findings indicate that the silicone-coated N-WPE dressing enhances wound healing since stimulates higher granulation tissue formation and causes minor tissue trauma during dressing changes.
C1 [Losi, Paola; Briganti, Enrica; Costa, Manolo; Sanguinetti, Elena; Soldani, Giorgio] CNR, Lab Biomat & Graft Technol, Inst Clin Physiol, I-54100 Massa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP Soldani, G (通讯作者)，CNR, Lab Biomat & Graft Technol, Inst Clin Physiol, Via Aurelia Sud, I-54100 Massa, Italy.
EM giorgio.soldani@ifc.cnr.it
OI Soldani, Giorgio/0000-0002-9042-0994; Losi, Paola/0000-0002-1350-8626
CR [Anonymous], WOUNDS LACERATIONS E
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NR 28
TC 8
Z9 10
U1 0
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD SEP
PY 2012
VL 23
IS 9
BP 2235
EP 2243
DI 10.1007/s10856-012-4701-8
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 998LY
UT WOS:000308242000019
PM 22692367
OA gold
DA 2026-07-24
ER

PT J
AU Goutos, I
   Ghosh, SJ
AF Goutos, I.
   Ghosh, S. J.
TI Gauze-based negative pressure wound therapy as an adjunct to
   collagen-elatin dermal template resurfacing
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE dermal template; Matriderm; negative pressure
ID VACUUM-ASSISTED CLOSURE; INTEGRA ARTIFICIAL SKIN; CONTROLLED-TRIAL;
   DRESSINGS
AB Objective: To report the first case series of gauze-based negative pressure wound therapy (NPWT) as an adjunct to collagen-elastin dermal template resurfacing and provide a brief overview of the current knowledge and controversies regarding NPWT in association with dermal templates.
   Method: In this prospective study, patients undergoing single stage resurfacing with Matriderm (Dr Suwelack Skin & Health Care, Germany) between September 2007 and September 2008 at Stoke Mandeville Hospital were identified and followed up.A gauze-based NPWT system (VISTA) was used to secure the dermal template and split skin graft to the wound bed. Rates of epithelialisation, the patients' analgesic requirements and patient concordance with the device were all recorded.
   Results: In the 10 patients studied (7 males and 3 females) this modality of vacuum therapy was found to be effective in all cases for bolstering single stage collagen-elastin dermal templates onto wounds, and contributed to excellent rates of epithelialisation (mean: 94%, range: 70-100%). Additionally, patient concordance with the device was excellent and the costs associated with its use were much lower compared with foam-based NPWT.
   Conclusion: We recommend the consideration of gauze-based NPWT as cost-effective alternative to foam based modalities in association with the use of dermal templates.
C1 [Goutos, I.; Ghosh, S. J.] Stoke Mandeville Hosp, Dept Plast Surg, Aylesbury HP21 8AL, Bucks, England.
RP Goutos, I (通讯作者)，Stoke Mandeville Hosp, Dept Plast Surg, Aylesbury HP21 8AL, Bucks, England.
EM ioannisgoutos@hotmail.com
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NR 25
TC 6
Z9 7
U1 0
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
J9 J WOUND CARE
JI J. Wound Care
PD FEB
PY 2011
VL 20
IS 2
BP 55
EP +
DI 10.12968/jowc.2011.20.2.55
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 929YV
UT WOS:000303102700003
PM 21378679
DA 2026-07-24
ER

PT J
AU Cocjin, HGB
   Jingco, JKP
   Tumaneng, FDC
   Coruña, JMR
AF Cocjin, Hansel Gould B.
   Jingco, Jair Kimri P.
   Tumaneng, Franklin Delano C.
   Coruna, Jose Maria R.
TI Wound-Healing Following Negative-Pressure Wound Therapy with Use of a
   Locally Developed AquaVac System as Compared with the Vacuum-Assisted
   Closure (VAC) System
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID RANDOMIZED-TRIAL; NPWT; MANAGEMENT; MULTICENTER; EXPERIENCE; PATIENT;
   DEVICE; LEG
AB Background: Negative-pressure wound therapy (NPWT) gained widespread clinical use after its introduction in the 1990s because of its many beneficial effects on the wound environment. However, high treatment costs have limited its use in third-world countries. The present study compares a low-cost, locally developed NPWT system with a commercially available system in terms of efficacy, reliability, ease of application, and safety.
   Methods: This prospective, randomized controlled trial involved 36 patients who were managed with NPWT with either a low-cost, locally developed system (AquaVac) or a commercially available Vacuum-Assisted Closure Advanced Therapy System (VAC ATS; KCI). The low-cost NPWT system described consists of a converted aquarium pump as a reusable vacuum source and a dressing system that can be found in the hospital supply room: food plastic wrap as an occlusive drape, surgical gauze as wound filler, nasogastric tubes as tubing, and used intravenous (IV) bottles as effluent canisters. The purpose of the study was to compare the 2 systems in terms of (1) time to apply the dressing, (2) exudate levels, (3) amount of granulation tissue, (4) wound size reduction, (5) average cost of treatment, (6) visual analog scale (VAS) pain scores, and (7) complications.
   Results: The experimental low-cost system had a small but statistically insignificant advantage over the commercially available system in terms of application time, pain during dressing changes, and wound contraction percentage. The 2 systems were comparable in terms of the amount of exudate, granulation tissue coverage, and VAS scores during the course of treatment. No wound or periwound complications were observed. The systems were significantly different in terms of cost, with the AquaVac system being 7 times less expensive than the VAC ATS system ($63.75 compared with $491.38 USD).
   Conclusions: The low-cost AquaVac system was shown to be comparable with the commercial VAC ATS system, suggesting that it is an effective and safe alternative method for NPWT in resource-challenged settings.
C1 [Cocjin, Hansel Gould B.; Jingco, Jair Kimri P.; Tumaneng, Franklin Delano C.; Coruna, Jose Maria R.] CLMMRH, Bacolod City, Philippines.
   [Cocjin, Hansel Gould B.; Jingco, Jair Kimri P.; Tumaneng, Franklin Delano C.; Coruna, Jose Maria R.] CLMMRH, Dept Orthopaed & Traumatol, Bacolod City, Philippines.
RP Cocjin, HGB (通讯作者)，CLMMRH, Dept Orthopaed & Traumatol, Bacolod City, Philippines.
EM hanselgouldcocjin@gmail.com
OI Cocjin, Hansel Gould/0000-0001-6010-431X
FU Philippine Council for Health Research and Development (PCHRD);
   Department of Science and Technology VI (DOST VI); Western Visayas
   Health Research and Development Consortium (WVHRDC)
FX The study grant was provided by the Philippine Council for Health
   Research and Development (PCHRD) in cooperation with the Department of
   Science and Technology VI (DOST VI) and Western Visayas Health Research
   and Development Consortium (WVHRDC). The funding source did not play a
   role in the investigation.
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NR 63
TC 16
Z9 19
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD NOV 20
PY 2019
VL 101
IS 22
BP 1990
EP 1998
DI 10.2106/JBJS.19.00125
PG 9
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA KG0ZQ
UT WOS:000509671300007
PM 31764361
DA 2026-07-24
ER

PT J
AU Petca, A
   Negoita, S
   Petca, RC
   Calo, O
   Sinescu, RD
AF Petca, Aida
   Negoita, Silvius
   Petca, Razvan-Cosmin
   Calo, Oana
   Sinescu, Ruxandra Diana
TI Ether-Based Polyurethane Foam for Vacuum-Assisted Closure (VAC) of
   Complicated Postoperative Abdominal Wound Dehiscence
SO MATERIALE PLASTICE
LA English
DT Article
DE polyether foam; silver layer; NPWT; infected wounds; surgical
   complications
ID THERAPY; RISK
AB Background. The macroporous polyurethane ether, foam was introduced in the medical . field, as early as the 90 ties, for the Vacuum-assisted closure (V.A.C.) of a wound. We describe our experience after treating abdominal wound dehiscence in a group of elderly gynecological patients with NPWT (Negative Pressure Wound Therapy), using ether foam coated with a silver layer. We reviewed elderly patients chart data that underwent abdominal surgery complicated with wound dehiscence treated with VAC for eighteen months. In all patients, the system used was the standard GranuFoam Silver (TM) dressing (different extents), which was usually replaced every 48/72 h. A total of 15 consecutive female patients were included. The median age was 67.3 (58-71) years. Duration of VAC treatment was median 14.2 (11-34) days, and we saw an improvement in wound repair but also clearance of S.S.I. on the third day after applying V.A.C. Ulta (TM). Definitive secondary closure of the wound was obtained in all patients, as the infection's site clearance. The abdominal VAC treatment with GranuFoam Silver (TM) dressing in patients with infected abdominal wound dehiscence is safe and has proper patient compliance. The latest evolution of the silver foam polyether dressing, in conjunction with NPWT therapy, offers a better antimicrobial effect and shorter healing stage.
C1 [Petca, Aida; Negoita, Silvius; Petca, Razvan-Cosmin; Calo, Oana; Sinescu, Ruxandra Diana] Carol Davila Univ Med & Pharm, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
   [Petca, Aida] Elias Univ Emergency Hosp, Dept Obstet & Gynecol, 17 Marasti Blvd, Bucharest 011461, Romania.
   [Negoita, Silvius] Elias Univ Emergency Hosp, Dept Anaesthesiol & Crit Care, 17 Marasti Blvd, Bucharest 011461, Romania.
   [Petca, Razvan-Cosmin] Prof Dr Th Burghele Clin Hosp, Dept Urol, 20 Panduri Str, Bucharest 050653, Romania.
   [Sinescu, Ruxandra Diana] Elias Univ Emergency Hosp, Dept Plast Surg & Reconstruct Microsurg, 17 Marasti Blvd, Bucharest 011461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Petca, RC (通讯作者)，Carol Davila Univ Med & Pharm, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.; Petca, RC (通讯作者)，Prof Dr Th Burghele Clin Hosp, Dept Urol, 20 Panduri Str, Bucharest 050653, Romania.
EM drpetca@gmail.com
RI ; NEGOITA, SILVIUS/AAG-2433-2021; Petca, Razvan - Cosmin/AAH-2462-2020;
   /ABD-2479-2020; Petca, Aida/AAH-2462-2020
OI Petca, Razvan - Cosmin/0000-0003-4496-1535; Petca, Razvan -
   Cosmin/0000-0003-4496-1535; Petca, Aida/0000-0002-4890-0978
CR Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
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NR 24
TC 3
Z9 3
U1 1
U2 5
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0025-5289
EI 2668-8220
J9 MATER PLAST
JI Mater. Plast.
PD JUN
PY 2020
VL 57
IS 2
BP 32
EP 38
DI 10.37358/MP.20.2.5348
PG 7
WC Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA OC9BZ
UT WOS:000579451200004
OA hybrid
DA 2026-07-24
ER

PT J
AU Gefen, A
   Russo, S
   Ciliberti, M
AF Gefen, Amit
   Russo, Serena
   Ciliberti, Marino
TI Revisiting negative pressure wound therapy from a mechanobiological
   perspective supported by clinical and pathological data
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE chronic wound care; influence zone theory; mechanisms of action;
   neo-angiogenesis; ultrasound Doppler
ID VACUUM-ASSISTED CLOSURE; CELL-SHAPE; RECOMMENDATIONS; DEFORMATIONS;
   MECHANISMS; DRESSINGS
AB Negative pressure wound therapy is used often in the management of surgical incisions, chronic wounds and subacute lesions, and there are numerous publications discussing its clinical application and outcomes. However, whilst clinical use and associated literature have expanded since these systems became commercially available in the 90s, important research and discussion around the mode of action have waned, leading to a deficit in the understanding of how this important therapy influences healing. Further, much research and many publications are predominantly reflective, discussing early theorem, some of which have been proven incorrect, or at least not fully resolved leading to misunderstandings as to how the therapy works, thus potentially denying the clinician the opportunity to optimise use towards improved clinical and economic outcomes. In this narrative review, we discuss established beliefs and challenges to same where appropriate and introduce important new research that addresses the manner in which mechanical strain energy (i.e., deformations) is transferred to tissue and how this influences biological response and healing. In addition, we assess and discuss the effect of different negative pressure dressing formats, how they influence the mode of action and how this understanding can lead to more efficient and effective use and clinical economic outcomes.
C1 [Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
   [Gefen, Amit] Univ Ghent, Univ Ctr Nursing & Midwifery, Dept Publ Hlth & Primary Care, Skin Integr Res Grp SKINT, Ghent, Belgium.
   [Gefen, Amit] Hasselt Univ, Fac Sci, Dept Math & Stat, Hasselt, Belgium.
   [Gefen, Amit] Hasselt Univ, Data Sci Inst, Fac Sci, Hasselt, Belgium.
   [Russo, Serena] Mediterranean Inst Transplantat & Highly Specializ, Palermo, Italy.
   [Ciliberti, Marino] Ctr Aziendale Riparaz Tissutale, Wound Care Ctr, Castellammare Di Stabia, Italy.
C3 Tel Aviv University; Ghent University; Ghent University Hospital;
   Hasselt University; Hasselt University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-69978 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
FU Mlnlycke Health Care; Ministry of Innovation, Science and Technology
   [001702603]
FX The authors are thankful to Mr. Brian Andrews (Global Marketing,
   Negative Pressure Wound Therapy, Molnlycke Health Care, Gothenburg,
   Sweden) whose vast industry experience contributed to the relevance of
   this work. This work was partially supported by the Israeli Ministry of
   Innovation, Science and Technology (Breakthrough Research Program Grant
   no. 001702603, awarded to Professor Amit Gefen in 2023). Authors AG and
   MC are paid consultants for Molnlycke Health Care.
CR Agency for Healthcare Research and Quality, 2019, Surgical Site Infections
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NR 50
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2024
VL 21
IS 12
AR e70098
DI 10.1111/iwj.70098
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9ZY1I
UT WOS:001619032800001
PM 39694469
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nemeth, N
   Peto, K
   Deak, A
   Sogor, V
   Varga, G
   Tanczos, B
   Balog, K
   Csiszko, A
   Godo, Z
   Szentkereszty, Z
AF Nemeth, Norbert
   Peto, Katalin
   Deak, Adam
   Sogor, Viktoria
   Varga, Gabor
   Tanczos, Bence
   Balog, Klaudia
   Csiszko, Adrienn
   Godo, Zoltan
   Szentkereszty, Zsolt
TI Hemorheological factors can be informative in comparing treatment
   possibilities of abdominal compartment syndrome
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Abdominal compartment syndrome; negative pressure wound therapy;
   microcirculation; hemorheology
ID UPDATED CONSENSUS DEFINITIONS; CLINICAL-PRACTICE GUIDELINES;
   INTRAABDOMINAL HYPERTENSION; PRESSURE; CLOSURE; MANAGEMENT; RHEOLOGY
AB BACKGROUND: Abdominal compartment syndrome (ACS) is a life-threatening condition, of which pathomechanism hasn't been completely clarified, yet. Furthermore, surgical therapy still needs optimization.
   OBJECTIVE: We aimed to investigate microcirculatory and micro-rheological alterations in ACS, using various temporary abdominal closure methods, including three settings of vacuum-assisted closure technique (negative pressure wound therapy, NPWT).
   METHODS: On anesthetized pigs, by intraabdominally placed and filled-up silicone bags, intraabdominal pressure at 30mmHg was maintained for 3 hours, and afterwards, decompressive laparotomy happened. In different experimental groups Bogota-bag or Vivano abdominal sets were applied (-50, -100, -150 mmHg) for 2 hours. Pressure monitoring was done by implanted sensors, hemorheological parameters were determined, and laser Doppler flowmetry tests were performed on the surface of intraabdominal organs.
   RESULTS: Treatment with Bogota-bag and -150mmHg vacuum increased erythrocyte aggregation, while deformability declined. Blood viscosity increased after treatment with -150 mmHg vacuum. The microcirculatory parameters of the NPWT groups were better in small intestine.
   CONCLUSIONS: ACS resulted in impairment of macro- and micro-rheological parameters and abdominal organs' microcirculation. All of the used techniques improved the results, however, applying Bogota-bag or -150 mmHg vacuum set showed worse microcirculatory and micro-rheological data than the settings at -100 or -50 mmHg.
C1 [Nemeth, Norbert; Peto, Katalin; Deak, Adam; Sogor, Viktoria; Varga, Gabor; Tanczos, Bence] Univ Debrecen, Fac Med, Dept Operat Tech & Surg Res, Debrecen, Hungary.
   [Balog, Klaudia; Csiszko, Adrienn; Szentkereszty, Zsolt] Univ Debrecen, Fac Med, Inst Surg, Debrecen, Hungary.
   [Godo, Zoltan] Univ Debrecen, Fac Informat, Dept Informat Technol, Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen
RP Nemeth, N (通讯作者)，Univ Debrecen, Fac Med, Dept Operat Tech & Surg Res, Inst Surg, Nagyerdeikrt 98, H-4032 Debrecen, Hungary.
EM nemeth@med.unideb.hu
RI ; Nemeth, Norbert/AAX-8704-2020; Petö, Katalin/IWD-5161-2023
OI Deak, Adam/0000-0001-7516-3152; Nemeth, Norbert/0000-0002-1162-3778;
   Tánczos, Bence/0000-0002-8892-3031; 
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NR 28
TC 5
Z9 6
U1 0
U2 3
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2016
VL 64
IS 4
BP 765
EP 775
DI 10.3233/CH-168027
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EN3UU
UT WOS:000395934200028
PM 27767980
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Raad, W
   Lantis, JC
   Tyrie, L
   Gendics, C
   Todd, G
AF Raad, Wissam
   Lantis, John C., II
   Tyrie, Leslie
   Gendics, Cynthia
   Todd, George
TI Vacuum-assisted closure instill as a method of sterilizing massive
   venous stasis wounds prior to split thickness skin graft placement
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Split thickness skin graft; Wound
   sterilisation
ID FOOT; OUTCOMES; ULCERS; TRIAL
AB Patients with massive venous stasis ulcers that have very high bacterial burdens represent some of the most difficult wounds to manage. The vacuum-assisted closure (VAC) device is known to optimise wound bed preparation; however, these patients have too high a bacterial burden for simple VAC application to facilitate this function. We present the application of the VAC with instillation of dilute Dakins solution as a way of bacterial eradication in these patients. Five patients with venous stasis ulcers greater than 200 cm(2) that were colonised with greater than 105 bacteria were treated with the VAC instill for 10 days with 12.5% Dakins solution, instilled for 10 minutes every hour. Two patients had multi-drug-resistant pseudomonas, three with MRSA. All the five had negative quantitative cultures, prior to split thickness skin graft with 100% take and complete healing at 1 year. Adequate delivery of bactericidal agents to the infected tissue can be very difficult, especially while promoting tissue growth. By providing a single delivery system for a bactericidal agent for a short period of time followed by a growth stimulating therapy, the VAC instill provides a unique combination that appears to maximise wound bed preparation.
C1 [Raad, Wissam; Lantis, John C., II; Tyrie, Leslie; Gendics, Cynthia; Todd, George] Columbia Univ, St Lukes Roosevelt Hosp, Dept Surg, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai Morningside; Mount Sinai West
RP Lantis, JC (通讯作者)，Columbia Univ, St Lukes Roosevelt Hosp Ctr, Suite 7A,1090 Amsterdam Ave, New York, NY 10025 USA.
EM jcl161@columbia.edu
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NR 24
TC 45
Z9 54
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2010
VL 7
IS 2
BP 81
EP 85
DI 10.1111/j.1742-481X.2010.00658.x
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NN
UT WOS:000287513600003
PM 20529147
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Iblher, N
   Fritsche, HM
   Katzenwadel, A
   Penna, V
   Eisenhardt, SU
   Stark, GB
   Lampert, F
AF Iblher, N.
   Fritsche, H. -M.
   Katzenwadel, A.
   Penna, V.
   Eisenhardt, S. U.
   Stark, G. B.
   Lampert, F.
TI Refinements in reconstruction of penile skin loss using intra-operative
   prostaglandin injections, postoperative tadalafil application and
   negative pressure dressings
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Skin graft; Penile reconstruction; Negative-pressure wound therapy;
   Tadalafil; PDE5-inhibitor; Prostaglandin
ID VACUUM-ASSISTED CLOSURE; FLAP SURVIVAL; ERECTILE DYSFUNCTION; WOUND
   CONTRACTION; GRAFTS; SILDENAFIL; RATS; MANAGEMENT; SHAFT
AB Purpose: Penile shaft skin defects represent demanding reconstructive tasks because a high degree of flexibility and stability of the skin grafts are essential to allow regular erections and sexual intercourse.
   Methods: A new concept of tailoring skin grafts to the erect penis by intra-operative application of prostaglandin E1 and postoperative stabilisation by negative-pressure wound therapy and pharmacological expansion by tadalafil was tested on four patients with penile shaft skin defects. Graft take, stability, pliability, softness and aesthetic results were evaluated up to at least 12 months postoperatively. The ratio of the skin transplanted area in the non-erect compared to the erect penis (non-erect/erect ratio) and the ratio of the skin transplanted area in the erect penis at 12 months compared to intra-operatively (Post/Pre ratio) was determined to define the amount of graft contraction and flexibility. International Index of Erectile Function (IIEF)-5 scores were evaluated postoperatively.
   Results: There were no complications. Graft take was 97, 100, 100 and 100%. Stable skin grafts were achieved after 2 weeks. Sexual intercourse was possible at 2-3 months. The Post/Pre ratio was between 81 and 87% and proves comparably mild contracture rates. The non-erect/erect ratio of 50-72% shows how significantly undersized penile shaft skin grafts are when adjusted to the non-erect penis and that an adequate flexibility for erections can be reconstructed. IIEF-5 scores proved regular potency in three patients; one patient was no longer sexually active.
   Conclusions: With the new concept of tailoring the skin graft to the erect penis, pharmacological expansion and external stabilisation by vacuum-assisted closure (VAC) dressing the difficult task of penile skin reconstruction can be facilitated, accelerated and the functional and aesthetic outcome improved compared to earlier efforts or to results presented in the literature. (C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Iblher, N.; Penna, V.; Eisenhardt, S. U.; Stark, G. B.; Lampert, F.] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany.
   [Fritsche, H. -M.] Caritas Krankenhaus St Josef, Dept Urol, Regensburg, Germany.
   [Katzenwadel, A.] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany.
C3 University of Freiburg; University of Freiburg
RP Iblher, N (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany.
EM niklas.iblher@uniklinik-freiburg.de
RI ; Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Lampert, Florian/0000-0003-4052-0601; Eisenhardt, Steffen
   Ulrich/0000-0003-4471-3160
CR Bandera BC, 2005, AM SURGEON, V76, P614
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NR 27
TC 10
Z9 10
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD OCT
PY 2012
VL 65
IS 10
BP 1377
EP 1383
DI 10.1016/j.bjps.2012.04.020
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 008ZS
UT WOS:000308995700020
PM 22633389
DA 2026-07-24
ER

PT J
AU Chan, M
   Yusuf, E
   Giulieri, S
   Perrottet, N
   Von Segesser, L
   Borens, O
   Trampuz, A
AF Chan, Monica
   Yusuf, Erlangga
   Giulieri, Stefano
   Perrottet, Nancy
   Von Segesser, Ludwig
   Borens, Olivier
   Trampuz, Andrej
TI A retrospective study of deep sternal wound infections: clinical and
   microbiological characteristics, treatment, and risk factors for
   complications
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Post-operative mediastinitis; Sternal osteomyelitis; Deep sternal wound
   infection; Sternotomy; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; LONG-TERM SURVIVAL; NEGATIVE-PRESSURE;
   POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY; POSTOPERATIVE
   MEDIASTINITIS; CLOSED-DRAINAGE; BACTERIAL LOAD; THERAPY; TRANSPOSITION
AB Deep sternal wound infection (DSWI) is a feared complication following cardiac surgery. This study describes clinical, microbiological, and treatment outcomes of DSWI and determines risk factors for complications. Of 55 patients with DSWI, 66% were male and mean age was 68.2 years. Initial sternotomy was for coronary artery bypass graft in 49% of patients. Sternal debridement at mean 25.4 +/- 18.3 days showed monomicrobial (94%), mainly Gram-positive infection. Secondary sternal wound infection (SSWI) occurred in 31% of patients, was mostly polymicrobial (71%), and was predominantly due to Gram-negative bacilli. Risk factors for SSWI were at least 1 revision surgery (odds ratio [OR] 4.8 [95% confidence interval {CI} 1.0-22.4], P = 0.047), sternal closure by muscle flap (OR 4.6[1.3-16.8], P = 0.02), delayed sternal closure (mean 27 versus 14 days, P = 0.03), and use of vacuum-assisted closure device (100% versus 58%, P = 0.008). Hospital stay was significantly longer in patients with SSWI (69 days versus 48 days, P = 0.04). (C) 2016 Elsevier Inc. All rights reserved.
C1 [Chan, Monica] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore.
   [Yusuf, Erlangga; Perrottet, Nancy; Borens, Olivier] Univ Lausanne Hosp, Sept Surg Unit, Lausanne, Switzerland.
   [Yusuf, Erlangga; Giulieri, Stefano; Trampuz, Andrej] Univ Lausanne Hosp, Infect Dis Serv, Lausanne, Switzerland.
   [Perrottet, Nancy] Univ Lausanne Hosp, Dept Pharm, Lausanne, Switzerland.
   [Von Segesser, Ludwig] Univ Lausanne Hosp, Cardiovasc Surg, Lausanne, Switzerland.
   [Yusuf, Erlangga] Univ Ziekenhuis Brussel, Dept Med Microbiol & Infect Control, Brussels, Belgium.
   [Trampuz, Andrej] Free & Humboldt Univ Berlin, Charite Univ Med, Ctr Musculoskeletal Surg, Berlin, Germany.
C3 Tan Tock Seng Hospital; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); Vrije Universiteit Brussel; University
   Hospital Brussels; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Yusuf, E (通讯作者)，Univ Lausanne Hosp, Sept Surg Unit, Lausanne, Switzerland.; Yusuf, E (通讯作者)，Univ Lausanne Hosp, Infect Dis Serv, Lausanne, Switzerland.
EM angga.yusuf@gmail.com
RI Yusuf, Erlangga/H-5166-2019; Giulieri, Stefano/IUO-3253-2023
OI Yusuf, Erlangga/0000-0003-4779-2191; Giulieri,
   Stefano/0000-0001-5366-1943
FU Healthcare Manpower Development Plan, Ministry of Health, Singapore
FX This study was supported by an educational grant to Monica Chan by the
   Healthcare Manpower Development Plan, Ministry of Health, Singapore.
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NR 42
TC 45
Z9 57
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0732-8893
EI 1879-0070
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD MAR
PY 2016
VL 84
IS 3
BP 261
EP 265
DI 10.1016/j.diagmicrobio.2015.11.011
PG 5
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA DF2PP
UT WOS:000371186500022
PM 26707065
DA 2026-07-24
ER

PT J
AU Kaplan, M
   Daly, D
   Stemkowski, S
AF Kaplan, Mark
   Daly, Darron
   Stemkowski, Stephen
TI Early Intervention of Negative Pressure Wound Therapy Using
   Vacuum-Assisted Closure in Trauma Patients: Impact on Hospital Length of
   Stay and Cost
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
ID MULTICENTER; MANAGEMENT
AB OBJECTIVE: The cost of treating complex traumatic wounds is substantial because of trauma severity, potential for infection, and delayed closure. Negative pressure wound therapy using reticulated open cell foam (NPWT/ROCF) as delivered by Vacuum-Assisted Closure* (KCI Licensing, Inc, San Antonio, Texas) is an established, viable option for treating traumatic wounds. The authors used retrospective data to study the clinical and cost-effective benefits of using NPWT/ROCF early on day 1 or day 2 of treatment for traumatic wounds as compared with using it late (on day 3 or later).
   METHODS: Hospital data records from trauma wound patients treated with NPWT/ROCF were retrospectively analyzed. Data were subdivided into 2 groups based on start of treatment. The group of patients treated on day 1 or 2 of their hospital stay was referred to as the early group, and that composed of patients treated on day 3 or later as the late group. Clinical and cost-effective metrics were compared between the 2 groups.
   RESULTS: For the early group, 518 patient records were included; 1000 records were reviewed for the late group. Early-group patients had fewer hospital inpatient days (10.6 vs 20.6 days; P < .0001), fewer treatment days (5.1 vs 6.0 days; P = .0498), shorter intensive care unit (ICU) stays (5.3 vs 12.4 days; P < .0001), and higher ICU admission rates (51.5 vs 44.5%; P = .0091) than the late group. Compared with late-group patients, early-group patients had lower total and variable costs per patient discharge ($43,956 vs $32,175; P < .0001 and $22,891 vs $15,805; P < .0001, respectively).
   CONCLUSION: Acute-care trauma wound patients receiving early NPWT/ROCF demonstrated significant reductions in length of stay, treatment days, and ICU stay, which resulted in significant reduced patient treatment costs. These results indicate that early intervention with NPWT/ROCF has potential clinical and cost-effective benefits for the treatment of traumatic wounds. ADV SKIN WOUND CARE 2009; 22: 128 - 32
C1 [Kaplan, Mark] Albert Einstein Med Ctr, Div Trauma & Surg Crit Care, Philadelphia, PA 19141 USA.
   [Daly, Darron] Kinet Concepts Inc, N Amer Profess Affairs, San Antonio, TX USA.
   [Stemkowski, Stephen] Premier Inc, Premier Res Serv, Charlotte, NC USA.
C3 Yeshiva University; Premier, Inc.
RP Kaplan, M (通讯作者)，Albert Einstein Med Ctr, Div Trauma & Surg Crit Care, Philadelphia, PA 19141 USA.
FU KCI Licensing, Inc.; KCI USA, Inc, San Antonio, Texas
FX Article sponsored by an educational grant from KCI Licensing, Inc.This
   study was supported by a grant from KCI USA, Inc, San Antonio, Texas.
   Editorial assistance was provided by Karen Beach and Julissa Ramos. *All
   trademarks and service marks designated herein are proprietary of KCI
   Licensing, Inc, its affiliates, and licensors.
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NR 20
TC 53
Z9 65
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD MAR
PY 2009
VL 22
IS 3
BP 128
EP 132
DI 10.1097/01.ASW.0000305451.71811.d5
PG 5
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA V19SE
UT WOS:000208091300006
PM 19247014
DA 2026-07-24
ER

PT J
AU Zhang, YZ
   Wu, WJ
   Shu, YJ
   Su, QY
   Wang, F
   Han, B
AF Zhang, Yuezhu
   Wu, Wenjie
   Shu, Yanjia
   Su, Qianya
   Wang, Fei
   Han, Bing
TI Vacuum sealing drainage successfully treated refractory sclerosing
   panniculitis
SO CLINICAL AND EXPERIMENTAL DERMATOLOGY
LA English
DT Article
AB Here, we describe a patient with refractory sclerosing panniculitis with a long disease course who was successfully treated using vacuum sealing drainage (VSD). As demonstrated in this patient, VSD has a favourable therapeutic effect on sclerosing panniculitis. It is reasonable to consider that VSD represents a safe and effective technique for the treatment of sclerosing panniculitis.
C1 [Zhang, Yuezhu; Wu, Wenjie; Shu, Yanjia; Su, Qianya; Wang, Fei] Southeast Univ, ZhongDa Hosp, Sch Med, Dept Dermatol, Nanjing, Peoples R China.
   [Han, Bing] Southeast Univ, ZhongDa Hosp, Sch Med, Dept Plast Surg, Nanjing, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Han, B (通讯作者)，Southeast Univ, ZhongDa Hosp, Sch Med, Dept Plast Surg, Nanjing, Peoples R China.
EM hanbingseven@seu.edu.cn
RI Su, Qianya/ABH-1425-2021
FU Southeast University Affiliated Zhongda Hospital; Affiliated to
   Southeast University, Jiangsu Province High-Level Hospital Construction
   Funds [2024GSPKY18]
FX This study was funded by Southeast University Affiliated Zhongda
   Hospital, Affiliated to Southeast University, Jiangsu Province
   High-Level Hospital Construction Funds, grant no. 2024GSPKY18.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   KIRSNER RS, 1993, J AM ACAD DERMATOL, V28, P623, DOI 10.1016/0190-9622(93)70085-8
   Miteva M, 2010, DERMATOL THER, V23, P375, DOI 10.1111/j.1529-8019.2010.01338.x
   Yang H, 2021, THER CLIN RISK MANAG, V17, P65, DOI 10.2147/TCRM.S282840
   Zhang L, 2020, EXP THER MED, V20, P2305, DOI 10.3892/etm.2020.8941
NR 5
TC 0
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0307-6938
EI 1365-2230
J9 CLIN EXP DERMATOL
JI Clin. Exp. Dermatol.
PD DEC 24
PY 2024
VL 50
IS 3
BP 714
EP 716
DI 10.1093/ced/llae442
EA DEC 2024
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Y3Z8D
UT WOS:001382405300001
PM 39414252
DA 2026-07-24
ER

PT J
AU Liu, BY
   Liu, JJ
   Ren, YR
   Xiang, JJ
   Xiao, BL
   Sun, YM
AF Liu, Bingyan
   Liu, Junjun
   Ren, Yanrui
   Xiang, Jinjian
   Xiao, Baolai
   Sun, Yimin
TI Clinical application of a custom-made simple subcutaneous negative
   pressure drainage device for the treatment of SSI after abdominal
   surgery: a randomized controlled trial
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE abdominal surgery; randomized controlled trial; surgical site infection;
   vacuum sealing drainage
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; THERAPY; PREVENTION
AB Background:The current gold standard for managing surgical site infections (SSIs) is the vacuum-assisted closure (VAC) technique, also known as vacuum sealing drainage (VSD). However, its high cost and technical complexity necessitate specialized health care personnel for proper application and monitoring, thereby limiting its widespread clinical adoption. Building on the theoretical framework and mechanistic principles of VSD systems, we developed a simplified subcutaneous negative pressure drainage device and conducted a preliminary evaluation of its clinical efficacy and potential for broader implementation. Objective:To evaluate the clinical efficacy of a novel, custom-designed simplified subcutaneous negative pressure drainage device for the treatment of SSIs following abdominal surgery. Methods:A total of 85 patients who were diagnosed with postoperative incisional infections following abdominal surgery between August 2022 and November 2024 were enrolled as study participants. These patients were randomly allocated using a computer-generated randomization sequence into either a standard care group or an intervention group. The standard care group received standard wound care, including conventional dressing changes, whereas the intervention group was treated with a custom-designed simplified subcutaneous negative pressure drainage device. The primary endpoint was wound healing status. The secondary endpoints included the wound healing time, frequency of dressing changes, cost of wound care, duration of antibiotic therapy, length of hospital stay, serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels, and patient satisfaction scores.Results:Compared with the standard care group, the intervention group demonstrated superior wound healing outcomes (P < 0.001). Furthermore, the intervention group demonstrated significantly shorter wound healing times, fewer dressing changes, lower wound care costs, a shorter duration of antibiotic use, and shorter hospital stays than did the standard care group (all P < 0.001). Posttreatment CRP and IL-6 levels were significantly lower in both groups (P < 0.001). Patient satisfaction scores were also significantly higher in the intervention group than in the standard care group (P < 0.001). Conclusion:The custom-designed, simple subcutaneous negative pressure drainage device effectively improves the healing of infected wounds after abdominal surgery. It shortens the duration of antibiotic therapy and hospital stay while reducing overall treatment costs. This device demonstrates satisfactory therapeutic efficacy and holds strong potential for widespread clinical application and promotion.
C1 [Liu, Bingyan; Liu, Junjun; Ren, Yanrui] Yangtze Univ, Affiliated Hosp 1, Dept Nursing, Jingzhou, Peoples R China.
   [Xiang, Jinjian; Xiao, Baolai; Sun, Yimin] Yangtze Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 8 Hangkong Rd, Jingzhou 434000, Hubei, Peoples R China.
C3 Yangtze University; Yangtze University
RP Sun, YM (通讯作者)，Yangtze Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, 8 Hangkong Rd, Jingzhou 434000, Hubei, Peoples R China.
EM bingyan189@163.com; 1524240872@qq.com; 709064048@qq.com;
   freeskyxiang@126.com; 414132346@qq.com; sunyimin545589834@163.com
FU Guiding Project of Jingzhou Science and Technology Program [2024HD91];
   Jingzhou Joint Scientific Research Fund Project [2024LHY19]
FX This research was funded by the Guiding Project of Jingzhou Science and
   Technology Program (Grant No. 2024HD91) and the Jingzhou Joint
   Scientific Research Fund Project (Grant No. ).
CR Agha R, 2025, Premier Journal of Science, DOI [10.70389/pjs.100082, 10.70389/PJS.100082, DOI 10.70389/PJS.100082]
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   Zhang CM, 2021, J ORTHOP SURG RES, V16, DOI 10.1186/s13018-021-02759-x
NR 24
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JAN
PY 2026
VL 112
IS 1
BP 990
EP 998
DI 10.1097/JS9.0000000000003504
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC9PK
UT WOS:001680465700025
PM 41056051
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Yamaguchi, Y
   Yanagi, T
   Sato, K
   Yoshimoto, N
   Hirata, Y
   Ujiie, I
   Nishimura, M
   Natsuga, K
   Shiiya, C
   Tsukinaga, I
   Shimizu, H
AF Yamaguchi, Yasuyuki
   Yanagi, Teruki
   Sato, Kazumasa
   Yoshimoto, Norihiro
   Hirata, Yu
   Ujiie, Inkin
   Nishimura, Machiko
   Natsuga, Ken
   Shiiya, Chihiro
   Tsukinaga, Ichiro
   Shimizu, Hiroshi
TI Portable negative-pressure wound therapy for pyoderma gangrenosum:
   Report of two cases
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE negative-pressure wound therapy; PICO single use negative-pressure wound
   therapy system; portable negative-pressure wound therapy device;
   pyoderma gangrenosum; ulcer
ID CONTROLLED-TRIAL
AB Pyoderma gangrenosum is a chronic non-infectious neutrophilic dermatosis that causes undermining ulcers. Topical therapies for the deep ulcers of pyoderma gangrenosum have not been established. To investigate whether negative-pressure wound therapy is effective for a pyoderma gangrenosum ulcer, we used the PICO single use negative-pressure wound therapy system (Smith & Nephew, London, UK) for two pyoderma gangrenosum patients. In these cases, the ulcers decreased in size and necrolytic tissue was removed notably. Moreover, there were no secondary infections nor was there Koebner phenomena. Our cases suggest that portable negative-pressure wound therapy can be a treatment option for deep, intractable ulcers caused by pyoderma gangrenosum. Because portable negative-pressure wound therapy devices afford increased mobility to patients, they can give the patient a better quality of life than standard negative-pressure wound therapy systems do.
C1 [Yamaguchi, Yasuyuki; Yanagi, Teruki; Sato, Kazumasa; Yoshimoto, Norihiro; Hirata, Yu; Ujiie, Inkin; Nishimura, Machiko; Natsuga, Ken; Shimizu, Hiroshi] Hokkaido Univ, Grad Sch Med, Dept Dermatol, Sapporo, Hokkaido, Japan.
   [Shiiya, Chihiro; Tsukinaga, Ichiro] KKR Sapporo Med Ctr, Dept Dermatol, Sapporo, Hokkaido, Japan.
C3 Hokkaido University
RP Yanagi, T (通讯作者)，Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, North 15 West 7, Sapporo, Hokkaido 0608638, Japan.
EM yanagi@med.hokudai.ac.jp
RI ; Natsuga, Ken/H-4050-2012; Yanagi, Teruki/D-4222-2017; Shimizu,
   Hiroshi/A-5193-2012
OI Yamaguchi, Yasuyuki/0000-0003-1996-1584; Yanagi,
   Teruki/0000-0003-2196-7600; 
FU Grants-in-Aid for Scientific Research [17K16317] Funding Source: KAKEN
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Binus AM, 2011, BRIT J DERMATOL, V165, P1244, DOI 10.1111/j.1365-2133.2011.10565.x
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NR 15
TC 6
Z9 6
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD APR
PY 2018
VL 45
IS 4
BP 483
EP 486
DI 10.1111/1346-8138.14180
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GD5KC
UT WOS:000430544900033
PM 29235669
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhu, J
   Yan, L
   Hu, R
   Yang, CB
   Wu, MZ
   An, Y
   Li, SQ
AF Zhu, Jin
   Yan, Li
   Hu, Rui
   Yang, Chunbao
   Wu, Mingzheng
   An, Ying
   Li, Shanqing
TI Artificial dermis combined with negative pressure wound therapy and
   plateletrich plasma to treat traumatic wounds: a retrospective study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE artificial dermis; negative pressure wound therapy; platelet-rich
   plasma; split-thickness skin grafting; wound; wound care; wound
   dressing; wound healing; wound repair
ID RICH PLASMA; INJURIES; RECONSTRUCTION; INSTILLATION; EXPERIENCE; DEFECTS
AB Objective: The reconstruction of complex soft tissue defects with exposure of bones and tendons represents an increasing challenge in wound care, especially in large extremity wounds. The aim of this study was to detect the clinical efficacy of combined use of negative pressure wound therapy (NPWT), artificial dermis (ADM), platelet -rich plasma (PRP) and split -thickness skin grafting (STSG) in the reconstruction of large traumatic extremity skin defects. Method: In this study, eight cases were treated with combined therapies for repairing complex extremity wounds and the results were reviewed retrospectively. After surgical debridement, all wounds received ADM, PRP and delayed STSG, which were all aided with NPWT. Results: The patients consisted of five males and three females, with a mean age of 44 years. A total of six lower extremity wounds were located at the foot/ankle, with exposed tendon in five, bone exposure in three and both in two. Of the group, two patients had exposed tendon on arm/hand wounds. The size of wounds and ADM averaged 126cm(2) and 42.3cm(2) , respectively. ADM was used to cover the exposed bone or tendon, the granulation and muscular tissue were covered with vacuum sealing drainage (VSD) directly, for NPWT. The survival rate of ADM averaged 98.9%. The average time for survival of ADM was 12.8 days and the mean uptake of autologous skin graft was 93.5%. Only one patient received repeated skin grafts. All patients achieved successful healing and reported no complications. The mean length of hospital stay was 36.1 days. Conclusion: Our study revealed that ADM in conjunction with NPWT, PRP and STSG could be used for repairing large traumatic extremity wounds. Wound closure was achieved without flaps, the aesthetic and functional outcomes were acceptable, and only one patient developed a 35% loss of skin graft.
C1 [Zhu, Jin; Yan, Li; Hu, Rui; Yang, Chunbao; Wu, Mingzheng; An, Ying; Li, Shanqing] Wuhan Fourth Hosp, Dept Orthopaed, Wuhan, Peoples R China.
RP Yan, L (通讯作者)，Wuhan Fourth Hosp, Dept Orthopaed, Wuhan, Peoples R China.
EM swyanli666@hotmail.com
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NR 28
TC 1
Z9 1
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2024
VL 33
IS 3
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA QU9D3
UT WOS:001223490900007
DA 2026-07-24
ER

PT J
AU Wang, HD
   Zhu, XF
   Xu, X
   Li, GZ
   Liu, N
   He, F
   Man, LB
AF Wang, Hai-Dong
   Zhu, Xiao-Fei
   Xu, Xiao
   Li, Gui-Zhong
   Liu, Ning
   He, Feng
   Man, Li-Bo
TI Emphysematous Pyelonephritis Treated with Vacuum Sealing Drainage
SO CHINESE MEDICAL JOURNAL
LA English
DT Editorial Material
DE Drainage; Emphysematous; Pyelonephritis
C1 [Wang, Hai-Dong; Zhu, Xiao-Fei; Xu, Xiao; Li, Gui-Zhong; Liu, Ning; He, Feng; Man, Li-Bo] Beijing Jishuitan Hosp, Dept Urol, Beijing 100035, Peoples R China.
RP Man, LB (通讯作者)，Beijing Jishuitan Hosp, Dept Urol, Beijing 100035, Peoples R China.
EM doctorwhd@163.com
CR Aboumarzouk OM, 2014, ARAB J UROL, V12, P106, DOI 10.1016/j.aju.2013.09.005
   Alsharif M, 2015, UROL ANNALS, V7, P494, DOI 10.4103/0974-7796.158503
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NR 4
TC 4
Z9 6
U1 0
U2 4
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JAN 20
PY 2017
VL 130
IS 2
BP 247
EP 248
DI 10.4103/0366-6999.198021
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EK5MV
UT WOS:000393971400022
PM 28091422
DA 2026-07-24
ER

PT J
AU Frykberg, RG
   O'Connor, RM
   Tallis, A
   Tierney, E
AF Frykberg, Robert G.
   O'Connor, Rachel M.
   Tallis, Arthur
   Tierney, Edward
TI Limb salvage using advanced technologies: a case report
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Advanced wound care therapies; Diabetic foot; Negative pressure wound
   therapy; Skin substitutes; Wound
ID DIABETIC FOOT ULCERS; VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY;
   AMPUTATION PREVENTION; MULTICENTER; CARE; OSTEOMYELITIS; STANDARD; BONE
AB Patients with severe acute and chronic lower extremity wounds often present a significant challenge in terms of limb salvage. In addition to control of infection, assuring adequate perfusion and providing standard wound care, advanced modalities are often required to facilitate final wound closure. We herein present a case study on a diabetic patient with gangrene and necrotising soft-tissue infection who underwent a forefoot pedal amputation to control the sepsis. Despite his non invasive vascular studies demonstrating poor healing potential at this level, he was not deemed suitable for revascularisation by our vascular surgeons and ankle-level amputation was recommended. Nonetheless, over a 5-month period using multiple advanced wound care therapies, wound closure was ultimately achieved.
C1 [Frykberg, Robert G.; O'Connor, Rachel M.; Tallis, Arthur; Tierney, Edward] Phoenix VA Hlth Care Syst, Podiatry Dept, Carl T Hayden VA Med Ctr, Phoenix, AZ USA.
RP Frykberg, RG (通讯作者)，Carl T Hayden VA Med Ctr, 650 E Indian Sch Rd, Phoenix, AZ 85012 USA.
EM Robert.frykberg@va.gov
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   Snyder RJ, 2010, WOUNDS, P3
   Snyder RJ, 2009, OSTOMY WOUND MANAG, V55, P28
   Taylor SM, 2008, AM SURGEON, V74, P84
   Taylor SM, 2007, J VASC SURG, V45, P304, DOI 10.1016/j.jvs.2006.09.038
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NR 33
TC 4
Z9 4
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2015
VL 12
IS 1
BP 53
EP 58
DI 10.1111/iwj.12050
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CA4CK
UT WOS:000348851700010
PM 23425603
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Wu, JF
   Zhang, XD
   Zhao, QM
   Mao, DS
   Lu, X
AF Wu, Jinfang
   Zhang, Xudong
   Zhao, Qiming
   Mao, Dongsheng
   Lu, Xin
TI Vacuum Sealing Drainage in the Treatment of Migrated Polyacrylamide
   Hydrogel after Breast Augmentation: A Case Report
SO BREAST CARE
LA English
DT Article
DE Vacuum sealing drainage; Polyacrylamide hydrogel; Breast augmentation;
   Complications
ID THERAPY
AB Background: Polyacrylamide hydrogel (PAAG) injection for breast augmentation can result in a variety of complications, including implant migration. The migrated PAAG can become colonized by pathogens, resulting in secondary infections which can be extremely difficult to treat. Case Report: We report the case of a 43-year-old female patient who underwent PAAG injection for breast augmentation. Implant migration was diagnosed 8 years after the initial injection. Conclusion: Here, we report the first use of vacuum sealing drainage as a convenient and effective alternative to manage the complications of extensive PAAG migration after breast augmentation.
C1 [Wu, Jinfang; Zhang, Xudong; Zhao, Qiming; Mao, Dongsheng; Lu, Xin] 117 PLA Hosp, Dept Plast & Reconstruct Surg, Hangzhou 310013, Zhejiang, Peoples R China.
RP Zhang, XD (通讯作者)，117 PLA Hosp, Dept Plast & Reconstruct Surg, 14 Lin Ying Rd, Hangzhou 310013, Zhejiang, Peoples R China.
EM zxdyqky@yahoo.com.cn
RI Zhao, Qiming/OHU-6722-2025
CR Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
   Do ER, 2012, ARCH PLAST SURG-APS, V39, P267
   Labler L, 2009, J TRAUMA, V66, P749, DOI 10.1097/TA.0b013e318171971a
   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
   Weed T, 2004, ANN PLAS SURG, V52, P276, DOI 10.1097/01.sap.0000111861.75927.4d
   Yu L, 2012, AESTHET PLAST SURG, V36, P1120, DOI 10.1007/s00266-012-9928-8
NR 6
TC 4
Z9 4
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-3791
EI 1661-3805
J9 BREAST CARE
JI Breast Care
PY 2014
VL 9
IS 4
BP 273
EP 275
DI 10.1159/000365954
PG 3
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Obstetrics & Gynecology
GA AQ2XR
UT WOS:000342653800008
PM 25404887
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Simek, M
   Chudoba, A
   Hajek, R
   Tobbia, P
   Molitor, M
   Nemec, P
AF Simek, Martin
   Chudoba, Adam
   Hajek, Roman
   Tobbia, Patrick
   Molitor, Martin
   Nemec, Petr
TI From open packing to negative wound pressure therapy. A critical
   overview of deep sternal wound infection treatment strategies after
   cardiac surgery
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Article
DE sternal wound infection; conventional treatment; pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; POST-STERNOTOMY MEDIASTINITIS; C-REACTIVE
   PROTEIN; POSTSTERNOTOMY MEDIASTINITIS; MUSCLE FLAPS; CLOSED DRAINAGE;
   RISK-FACTORS; STERNOCUTANEOUS FISTULAS; ANTIBIOTIC IRRIGATION; SUCTION
   DRAINAGE
AB Deep sternal wound infection is a challenging aspect of modern cardiac surgery. The considerable mortality rate, devastating morbidity and, negative impact on long-term survival has driven cardiac and plastic surgeons to seek a more advantageous treatment solution.This review summarizes progress in the field of deep sternal wound infection treatment after cardiac surgery. Emphasis is placed on outcomes analysis of contemporary treatment strategy based on negative pressure wound therapy followed by sternotomy wound reconstruction, and its comparison with conventional treatment modalities used afore. Furthermore, complications and drawbacks of treatment strategies are critically evaluated to outline current options for successfully managing this life-threatening complication following cardiac surgery
C1 [Simek, Martin; Hajek, Roman] Univ Hosp Olomouc, Dept Cardiac Surg, Olomouc, Czech Republic.
   [Simek, Martin; Chudoba, Adam] Palacky Univ Olomouc, Fac Med & Dent, Olomouc, Czech Republic.
   [Tobbia, Patrick] Reg Med Ctr, Dept Cardiovasc Med, 624 Hosp Dr, Mt Home, AR USA.
   [Molitor, Martin] Hosp Na Bulovce, Dept Plast Surg, Prague, Czech Republic.
   [Nemec, Petr] Ctr Cardiovasc & Transplant Surg, Brno, Czech Republic.
C3 University Hospital Olomouc; Palacky University Olomouc; Bulovka
   University Hospital
RP Simek, M (通讯作者)，Univ Hosp Olomouc, Dept Cardiac Surg, Olomouc, Czech Republic.; Simek, M (通讯作者)，Palacky Univ Olomouc, Fac Med & Dent, Olomouc, Czech Republic.
EM martin.simek@c-mail.cz
RI ; /AAF-8445-2021; Hajek, Roman/AAB-4232-2020
OI Šimek, Martin/0000-0001-5377-2096; nemec, petr/0000-0002-4542-913X; 
FU MH CZ - DRO [00098892]
FX This work was supported by MH CZ - DRO (FNO1, 00098892).
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NR 91
TC 1
Z9 2
U1 0
U2 5
PU PALACKY UNIV, MEDICAL FAC
PI OLOMOUC
PA CENTRAL LIBRARY, HNEVOTINSKA 3, OLOMOUC, 00000, CZECH REPUBLIC
SN 1213-8118
EI 1804-7521
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PD DEC
PY 2018
VL 162
IS 4
BP 263
EP 271
DI 10.5507/bp.2018.053
PG 9
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA HJ8ZI
UT WOS:000457488200003
PM 30215435
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Hao, S
   Juan, L
   Xin, W
AF Hao, S.
   Juan, L.
   Xin, W.
TI Treatment of traumatically cutaneous necrosis of buttocks using vacuum
   sealing drainage combined with ileostomy
SO EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
LA English
DT Article
DE Vacuum sealing drainage (VSD); Cutaneous necrosis; Skin transplantation;
   Ileostomy
ID ASSISTED CLOSURE; WOUND-INFECTION; THERAPY
AB The purpose of this study is to evaluate the surgical technique and review the therapeutic effect of vacuum sealing drainage combined with ileostomy treating patients of traumatically buttock skin necrosis.
   26 patients with buttock wounds were dressed and 6-12 days later, buttock skin necrosis boundaries were clear and debridement was performed. General surgeons were invited to perform the ileostomy. Thorough debridement was conducted and vacuum sealing drainage (VSD) devices were used to cover buttock wounds. Debridement and VSD were operated every 5-7 days until the granulation tissue of buttock wound was fresh. Then epidermal skin graft from thigh was performed to cover the granulation wound. About 3 months later after skin graft survival completely, the ileum was reversed by general surgeons and the patients recovered defecation using anus.
   The granulation tissues of all patients were fresh after debridement and VSD 2-3 times. In 20 cases, transplanted epidermal skin grew well. In six cases, necrosis was observed at the margins of the flap and further debridement and skin graft were conducted. During the follow-up period of approximate 6 months, the flaps grew well and the patients defecated normally from anus.
   Treating traumatically cutaneous necrosis of buttocks with vacuum sealing drainage and ileostomy can gain good therapeutic effect.
C1 [Hao, S.; Xin, W.] Yantai Yuhuangding Hosp, Dept Traumat Orthopaed, Yantai, Shandong, Peoples R China.
   [Juan, L.] Yantai Ctr Dis Control & Prevent, Yantai, Shandong, Peoples R China.
RP Juan, L (通讯作者)，Yantai Ctr Dis Control & Prevent, Yantai, Shandong, Peoples R China.
EM shj1022@163.com; suhj78@163.com
CR [Anonymous], WORLD J SURG ONCOL
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NR 12
TC 4
Z9 5
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-9933
EI 1863-9941
J9 EUR J TRAUMA EMERG S
JI Eur. J. Trauma Emerg. Surg.
PD FEB
PY 2016
VL 42
IS 1
BP 87
EP 90
DI 10.1007/s00068-015-0509-9
PG 4
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA DD9RY
UT WOS:000370264500013
PM 26038028
DA 2026-07-24
ER

PT J
AU Georgakarakos, E
   Charalampidis, D
   Kakagia, D
   Georgiadis, GS
   Lazarides, MK
   Papanas, N
AF Georgakarakos, Efstratios
   Charalampidis, Dimitris
   Kakagia, Despoina
   Georgiadis, George S.
   Lazarides, Miltos K.
   Papanas, Nikolaos
TI Current Achievements With Topical Negative Pressure to Improve Wound
   Healing in Dehiscent Ischemic Stumps of Diabetic Patients: A Case Series
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE diabetes; granulation; ischemia; negative pressure treatment; wound
   healing
ID VACUUM-ASSISTED-CLOSURE; SUBATMOSPHERIC PRESSURE; HYPERBARIC-OXYGEN;
   THERAPY; FOOT; AMPUTATIONS; MULTICENTER; EXPRESSION; ULCER; FLUID
AB Negative pressure wound therapy has been increasingly used either as a primary or as an adjunctive therapeutic measure to treat a variety of recalcitrant wounds during the past years. It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series presents our preliminary experience with the use of a Topical Negative Pressure system in the treatment of challenging ischemic wounds of diabetic patients. It aims to underscore its beneficial effects and explore its potential role in the management of ischemic amputated stumps to avoid ipsilateral re-amputation at a higher level.
C1 [Georgakarakos, Efstratios; Charalampidis, Dimitris; Georgiadis, George S.; Lazarides, Miltos K.] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Vasc Surg, Komotini, Greece.
   [Kakagia, Despoina] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Plast & Reconstruct Surg, Komotini, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Diabet Foot, Komotini, Greece.
C3 Democritus University of Thrace; Democritus University of Thrace;
   Democritus University of Thrace
RP Georgakarakos, E (通讯作者)，Univ Hosp Alexandroupolis, Dept Vasc Surg, Alexandroupolis 68100, Greece.
EM efstratiosgeorg@gmail.com
RI Kakagia, Despoina/AAP-1202-2021; Lazarides, Miltos/K-9070-2019;
   Georgakarakos, Efstratios/AAP-2524-2021
OI Kakagia, Despoina/0000-0003-2107-6170; Lazarides,
   Miltos/0000-0003-3458-7412; 
CR [Anonymous], CURR VASC PHARM
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NR 41
TC 9
Z9 10
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD JUN
PY 2013
VL 12
IS 2
SI SI
BP 138
EP 145
DI 10.1177/1534734613483769
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 301GE
UT WOS:000330520000008
PM 23667104
DA 2026-07-24
ER

PT J
AU Kollrack, YBM
   Moellenhoff, G
AF Kollrack, Yvonne Bernadette Maria
   Moellenhoff, Gunnar
TI Infected Internal Fixation after Ankle Fractures-A Treatment Path
SO JOURNAL OF FOOT & ANKLE SURGERY
LA English
DT Article
DE fibula; negative pressure wound therapy; osteosynthesis; surgery; tibia;
   trauma
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY
AB In the emergency treatment of infected internal fixation after ankle fractures, the infection needs to be resolved quickly to protect the implants, bone, and tendons. Vacuum wound therapy (topical negative pressure therapy) has been used for more than 15 years to assist in closure and to accelerate healing of a wide range of wounds. In the present report, we describe the results of treatment of 7 angiopathic (dysvascular) patients who developed a deep wound infection after ankle osteosynthesis. Each patient was treated with initial surgical debridement, followed by vacuum wound therapy and meshed split-thickness skin graft transplantation. The mean inpatient length of vacuum wound therapy was 14.0 +/- 4.31 days, and the mean total duration of vacuum treatment was 54.43 +/- 7.74 days. (C) 2012 by the American College of Foot and Ankle Surgeons. All rights reserved.
C1 [Kollrack, Yvonne Bernadette Maria; Moellenhoff, Gunnar] Univ Munster, Acad Teaching Hosp, Raphaelsklin Muenster, Dept Traumatol, D-48143 Munster, Germany.
C3 University of Munster
RP Kollrack, YBM (通讯作者)，Univ Munster, Acad Teaching Hosp, Raphaelsklin Muenster, Dept Traumatol, Loerstr 23, D-48143 Munster, Germany.
EM e1doktor@yahoo.de
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NR 27
TC 6
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1067-2516
EI 1542-2224
J9 J FOOT ANKLE SURG
JI J. Foot Ankle Surg.
PD JAN-FEB
PY 2012
VL 51
IS 1
BP 9
EP 12
DI 10.1053/j.jfas.2011.10.018
PG 4
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 866HU
UT WOS:000298372100003
PM 22196454
DA 2026-07-24
ER

PT J
AU Shestak, KC
AF Shestak, Kenneth C.
TI The Internal Negative-Pressure Wound Control System: A Paradigm Shift
   for Promoting Deep Space Healing in Complex Surgically Created Wounds
SO AESTHETIC SURGERY JOURNAL
LA English
DT Article
ID PROGRESSIVE TENSION SUTURES; VACUUM-ASSISTED CLOSURE; ABDOMINAL-WALL;
   SEROMA; ABDOMINOPLASTY; THERAPY; PREVENTION; SURGERY
AB This article introduces a new technology to minimize seroma and promote more predictable healing in surgically created deep space wounds. Its novel design internalizes the delivery of a continuously generated high negative pressure (-125 mmHg) throughout the surgically created space by means of a multibranched Manifold. In a small prospective cohort case study of 24 patients undergoing full abdominoplasty, all patients underwent placement of this device, which was removed 7 days postoperatively. Results at 30 days revealed no evidence of wound-healing problems, no clinical seroma, and no device malfunction. The internalization of a constant negative-pressure wound therapy provided by this system has the potential to significantly reduce clinical seroma, and to produce more consistent apposition of interfaces in deep tissue spaces in complex wounds seen in plastic surgery and other surgical disciplines.
C1 [Shestak, Kenneth C.] Univ Pittsburgh UPMC, Dept Plast Surg, Plast Surg, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Pittsburgh Medical Center
RP Shestak, KC (通讯作者)，Univ Pittsburgh, UPMC Aesthet Surg Ctr, Dept Plast Surg, Sch Med, 3380 Blvd Allies,Suite 180, Pittsburgh, PA 15213 USA.
EM shestakkc@upmc.edu
CR Andrades P, 2007, PLAST RECONSTR SURG, V120, P935, DOI 10.1097/01.prs.0000253445.76991.de
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1090-820X
EI 1527-330X
J9 AESTHET SURG J
JI Aesthet. Surg. J.
PD NOV
PY 2021
VL 41
IS 11
BP NP1543
EP NP1549
DI 10.1093/asj/sjab307
EA AUG 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA XU3OB
UT WOS:000734177600051
PM 34347042
DA 2026-07-24
ER

PT J
AU Sun, QY
   Li, SY
   Xu, HY
   Guan, XX
   Ye, FF
AF Sun, Qiaoyun
   Li, Suyan
   Xu, Hongyan
   Guan, Xiaoxaio
   Ye, Feifei
TI Experience With Wound Care in a Case With ECMO Cannulation Using a
   Self-Made Vacuum Sealing Drainage Device With Constant- Temperature
   Flushing
SO WOUND MANAGEMENT & PREVENTION
LA English
DT Article
DE ECMO; Vacuum Sealing Drainage; Incision Care
AB Background:This : This study reports experience of wound care at the site of cannulation in the case of a patient with dilated cardiomyopathy (DCM) weaned from extracorporeal membrane oxygenation (ECMO). Purpose: To describe the use of a self-made vacuum-sealing drainage device with constant-temperature flushing to manage wound exudates in the cannulation site, aiming to create an environment conducive to wound healing. Materials and Methods: Exudates from the wound were processed using the vacuum-sealing drainage technique combined with constant-temperature flushing. Anti-infective agents were systemically administered to control infection and promote wound healing. Additionally, the patient's nutritional status, pain management, psychological well-being, and rehabilitation were assessed and managed as part of the comprehensive care approach. Results: The wound exhibited gradual healing under this multifaceted care strategy. After 48 days of treatment, the patient demonstrated stable disease conditions and achieved wound closure. The patient was subsequently transferred to a general ward for further care. Conclusion: The use of a self-made vacuum-sealing drainage device with constant-temperature flushing, along with comprehensive patient management, proved effective in wound care for a critically ill patient with ECMO cannulation. This approach fosters an optimal environment for wound healing and contributes to patient recovery and stability.
C1 [Sun, Qiaoyun; Li, Suyan] Zhejiang Xiaoshan Hosp, Dept Emergency Intens Care Unit, Hangzhou, Zhejiang, Peoples R China.
   [Xu, Hongyan] Zhejiang Xiaoshan Hosp, Nursing Dept, Hangzhou, Zhejiang, Peoples R China.
   [Guan, Xiaoxaio; Ye, Feifei] Zhejiang Hosp, Dept Crit Care Med, Lingyin Rd 12, Hangzhou, Zhejiang, Peoples R China.
RP Ye, FF (通讯作者)，Zhejiang Hosp, Dept Crit Care Med, Lingyin Rd 12, Hangzhou, Zhejiang, Peoples R China.
EM 821900464@qq.com
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NR 13
TC 0
Z9 1
U1 0
U2 3
PU HMP
PI MALVERN
PA 70 E SWEDESFORD RD, STE 100, MALVERN, PA 19355 USA
SN 2640-5237
EI 2640-5245
J9 WOUND MANAG PREV
JI Wound Manag. Prev.
PD SEP
PY 2024
VL 70
IS 3
AR 23070
DI 10.25270/wmp.23070
PG 7
WC Dermatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing
GA J1O0T
UT WOS:001334822500004
PM 39361345
DA 2026-07-24
ER

PT J
AU Bueno-Lledo, J
   Martinez-Hoed, J
   Pous-Serrano, S
AF Bueno-Lledo, Jose
   Martinez-Hoed, Jesus
   Pous-Serrano, Salvador
TI Negative pressure therapy in abdominal wall surgery
SO CIRUGIA ESPANOLA
LA English
DT Article
DE Negative pressure therapy; VAC (R); Hernia; Abdominal wall surgery; Mesh
   infection; Biofilm; Incisional therapy; Fascial traction
ID MEDIATED FASCIAL TRACTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY; OPEN
   ABDOMEN; MESH INFECTION; HERNIA REPAIR; RECONSTRUCTION; MANAGEMENT;
   GAUZE; FOAM
AB Negative pressure wound therapy (NPWT) is widely known in surgical practice. The initial indications for NPWT were chronic wounds, especially diabetic foot, vascular and decubitus ulcers, and infected traumatic wounds. Nowadays, the use has been widely increased. Although in the field of abdominal wall surgery, it has mainly been used in the treatment of surgical wound complications after hernia repair, other indications have been added after years of experience in the management of NPWT.
   Therefore, the aim of this article is to analyze and review the main indications of NPWT in abdominal wall surgery, as well as the advantages obtained with its application. (C) 2021 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Bueno-Lledo, Jose; Pous-Serrano, Salvador] Univ Valencia, Hosp Univ & Politecn La Fe, Unidad Cirugia Pared Abdominal, Valencia, Spain.
   [Martinez-Hoed, Jesus] Hosp Rafael Angel Calderon Guardia, San Jose, Costa Rica.
C3 Hospital Universitari i Politecnic La Fe; University of Valencia
RP Bueno-Lledo, J (通讯作者)，Univ Valencia, Hosp Univ & Politecn La Fe, Unidad Cirugia Pared Abdominal, Valencia, Spain.
EM buenolledo@hotmail.com
RI ; Bueno-Lledó, Jose/I-2674-2019
OI Pous-Serrano, Salvador/0000-0002-2931-0366; Bueno-Lledó,
   Jose/0000-0002-3116-5022
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NR 45
TC 2
Z9 8
U1 2
U2 7
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0009-739X
EI 1578-147X
J9 CIR ESPAN
JI Cir. Espan.
PD AUG
PY 2022
VL 100
IS 8
BP 464
EP 471
DI 10.1016/j.ciresp.2021.12.006
EA JUL 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 3F3TC
UT WOS:000830592600002
PM 35584763
DA 2026-07-24
ER

PT J
AU Yang, LQ
   Zhao, N
   Yang, M
   Huang, J
   Fu, XM
   Lei, CJ
   Cai, PZ
AF Yang, Liuqing
   Zhao, Ning
   Yang, Min
   Huang, Jiao
   Fu, Xiaomin
   Lei, Changjiang
   Cai, Pengzhu
TI 被撤回的出版物: Diabetic foot wound ulcers management by vacuum sealing
   drainage: A meta-analysis (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE diabetic foot ulcer; duration of therapy; vacuum sealing drainage; wound
   healing
ID ASSISTED CLOSURE; COMPRESSION THERAPY; RANDOMIZED-TRIAL; STANDARD;
   MULTICENTER; CARE
AB The meta-analysis aimed to assess and compare diabetic foot wound ulcer management by vacuum sealing drainage. Using dichotomous or contentious random- or fixed-effects models, the outcomes of this meta-analysis were examined, and the odds ratio (OR) and the mean difference (MD) with 95% confidence intervals (CIs) were computed. Twenty-three examinations from 2000 to 2023 were enrolled for the present meta-analysis, including 1928 individuals with diabetic foot ulcers. Vacuum sealing drainage had significantly lower wound healing (OR, 2.35; 95% CI, 1.79-3.08, p < 0.001), lower duration of therapy (MD, -6.19; 95% CI, -10.06 to -2.32, p = 0.002), higher wound size reduction (MD, 4.22; 95% CI, 0.87-7.56, p = 0.01) and lower complication (OR, 0.32; 95% CI, 0.13-0.80, p = 0.01) compared with standard therapy in patients with diabetic foot ulcers. The examined data revealed that vacuum sealing drainage had significantly lower wound healing, duration of therapy and complication rates, as well as higher wound size reduction, compared with standard therapy in patients with diabetic foot ulcers. Yet, attention should be paid to its values since most of the selected examinations had a low sample size.
C1 [Yang, Liuqing] Fifth Hosp Wuhan, Dept Rehabil, Wuhan, Hubei, Peoples R China.
   [Zhao, Ning] Fifth Hosp Wuhan, Dept Pharm, Wuhan, Hubei, Peoples R China.
   [Yang, Min] Fifth Hosp Wuhan, Dept Gen Med, Erqiao St Community Hlth Serv Ctr, Wuhan, Hubei, Peoples R China.
   [Huang, Jiao] Fifth Hosp Wuhan, Dept Gen Med, Wuli St Community Hlth Serv Ctr, Wuhan, Hubei, Peoples R China.
   [Fu, Xiaomin] Guangdong Med Univ, Dept Anorectal Surg, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China.
   [Lei, Changjiang] Fifth Hosp Wuhan, Dept Oncol, Wuhan, Hubei, Peoples R China.
   [Cai, Pengzhu] Guangdong Med Univ, Dept Urol 2 Ward, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China.
   [Cai, Pengzhu] Guangdong Med Univ, Dept Urol 2 Ward, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Guangdong
   Medical University
RP Lei, CJ (通讯作者)，Fifth Hosp Wuhan, Dept Oncol, Wuhan, Hubei, Peoples R China.; Cai, PZ (通讯作者)，Guangdong Med Univ, Dept Urol 2 Ward, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.
EM lcj852_csa@outlook.com; 16789702@qq.com
FU Hubei Province Health and Family Planning Scientific Research Project
   [WJ2023M135]; Research project of Traditional Chinese Medicine of Hubei
   Administration of Traditional Chinese Medicine [ZY2023F064]; Wuhan
   Knowledge Innovation Special Basic Research Project [2022020801010575]
FX Hubei Province Health and Family Planning Scientific Research Project,
   Grant/Award Number: WJ2023M135; Research project of Traditional Chinese
   Medicine of Hubei Administration of Traditional Chinese Medicine,
   Grant/Award Number: ZY2023F064; Wuhan Knowledge Innovation Special Basic
   Research Project, Grant/Award Number: 2022020801010575
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NR 49
TC 7
Z9 8
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN
PY 2024
VL 21
IS 1
DI 10.1111/iwj.14390
EA SEP 2023
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA IT5Y9
UT WOS:001067247600001
PM 37704593
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nakayama, M
AF Nakayama, Mitsuyuki
TI Applying negative pressure therapy to deep pressure ulcers covered by
   soft necrotic tissue
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure therapy; Pressure ulcer
ID VACUUM-ASSISTED CLOSURE; WOUND CONTROL; CELLS
AB Negative pressure therapy was applied to 39 deep pressure ulcers covered by soft necrotic tissue. All of the wounds were so deep that there were bones or ligaments just beneath the soft necrotic tissue. They had already received several types of conservative therapy including a necrotomy for periods ranging from 1 to 72 months. The wounds were minimally debrided and put in an adequately wet environment with negative pressure. This environment was established by the application of a suction-dressing. All of these wounds showed clear wound beds within only 1 month. All of the wounds were successfully cured, either with or without a musculocutaneous flap. Negative pressure wound therapy is thus considered to be one of the choices for the management of non healing deep pressure ulcers covered by soft necrotic tissue.
C1 Kanoiwa Hosp, Dept Vasc Surg, Yamanashi 4050018, Japan.
RP Nakayama, M (通讯作者)，Kanoiwa Hosp, Dept Vasc Surg, 1309 Kamikanogawa, Yamanashi 4050018, Japan.
EM mitsu88@mx5.nns.ne.jp
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NR 12
TC 6
Z9 8
U1 0
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2010
VL 7
IS 3
BP 160
EP 166
DI 10.1111/j.1742-481X.2010.00667.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 723NP
UT WOS:000287513800005
PM 20455957
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Baharestani, MM
   Gabriel, A
AF Baharestani, Mona Mylene
   Gabriel, Allen
TI Use of negative pressure wound therapy in the management of infected
   abdominal wounds containing mesh: an analysis of outcomes
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Infected abdominal wound; Negative pressure wound therapy; NPWT;
   Synthetic mesh; Vacuum assisted closure
ID VACUUM-ASSISTED CLOSURE; INCISIONAL HERNIA REPAIR; CLINICAL-EXPERIENCE;
   VENTRAL HERNIA; WALL DEFECTS; COMPLICATIONS; TRIAL
AB The purpose of this study was to examine the clinical outcomes of negative pressure wound therapy (NPWT) using reticulated open-cell foam (ROCF) in the adjunctive management of abdominal wounds with exposed and known infected synthetic mesh. A non randomised, retrospective review of medical records for 21 consecutive patients with infected abdominal wounds treated with NPWT was conducted. All abdominal wounds contained exposed synthetic mesh [composite, polypropylene (PP), or knitted polyglactin 910 (PG) mesh]. Demographic and bacteriological data, wound history, pre-NPWT and comparative post-NPWT, operative procedures and complications, hospital length of stay (LOS) and wound healing outcomes were all analysed. Primary endpoints measured were (1) hospital LOS prior to initiation of NPWT, (2) total time on NPWT, (3) hospital LOS from NPWT initiation to discharge and (4) wound closure status at discharge. A total of 21 patients with abdominal wounds with exposed, infected mesh were treated with NPWT. Aetiology of the wounds was ventral hernia repair (n = 11) and acute abdominal wall defect (n = 10). Prior to NPWT initiation, the mean hospital LOS for the composite, PP and PG meshes were 76 days (range: 21-171 days), 51 days (range: 32-62 days) and 19 days (range: 12-39 days), respectively. The mean hospital LOS following initiation of NPWT for wounds with exposed composite, PP and PG mesh were 28, 31 and 32 days, respectively. Eighteen of the 21 wounds (86%) reached full closure after a mean time of 26 days of NPWT and a mean hospital LOS of 30 days postinitiation of NPWT. Three wounds, all with composite mesh left in situ, did not reach full closure, although all exhibited decreased wound dimensions, granulating beds and decreased surface area exposure of mesh. During NPWT/ROCF, one hypoalbuminemic patient with exposed PP mesh developed an enterocutaneous fistula over a prior enterotomy site. This patient subsequently underwent total mesh extraction, takedown of the fistula and PP mesh replacement followed by reinstitution of NPWT and flap closure. In addition to appropriate systemic antibiotics and nutritional optimisation, the adjunctive use of NPWT resulted in successful closure of 86% of infected abdominal wounds with exposed prosthetic mesh. Patient hospital LOS (except those with PG mesh), operative procedures and readmissions were decreased during NPWT compared with treatment prior to NPWT. Future multi-site prospective, controlled studies would provide a strong evidence base from which treatment decisions could be made in the management of these challenging and costly cases.
C1 [Baharestani, Mona Mylene] James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
   [Baharestani, Mona Mylene] E Tennessee State Univ, Quillen Coll Med, Dept Surg, Johnson City, TN 37614 USA.
   [Gabriel, Allen] SW Med Grp Plast Surg, Vancouver, WA USA.
   [Gabriel, Allen] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA USA.
C3 East Tennessee State University; Loma Linda University
RP Baharestani, MM (通讯作者)，James H Quillen Vet Affairs Med Ctr, Johnson City, TN USA.
EM mona.baharestani@va.gov
RI Gabriel, Allen/AFK-3548-2022
CR AGRAWAL S, 2008, EUR J VASC ENDOVASC, V15, P1
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NR 35
TC 33
Z9 36
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2011
VL 8
IS 2
BP 118
EP 125
DI 10.1111/j.1742-481X.2010.00756.x
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 735YW
UT WOS:000288457700005
PM 21176107
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Yang, L
   Zhao, N
   Yang, M
   Huang, J
   Fu, X
   Lei, C
   Cai, P
AF Yang, L.
   Zhao, N.
   Yang, M.
   Huang, J.
   Fu, X.
   Lei, C.
   Cai, P.
TI 撤稿声明: Diabetic Foot Wound Ulcers Management by Vacuum Sealing Drainage:
   A Meta-Analysis
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
CR Yang LQ, 2024, INT WOUND J, V21, DOI 10.1111/iwj.14390
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR
PY 2025
VL 22
IS 3
AR e14390
DI 10.1111/iwj.70258
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA DA7WP
UT WOS:001678993500001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Pang, LM
   Kong, FB
   Wang, XT
   Li, DG
   Li, YB
   Sun, PL
   Huang, HY
   Liu, CQ
   Wei, M
AF Pang, Li-Ming
   Kong, Fan-Biao
   Wang, Xiao-Tong
   Li, De-Gang
   Li, Yu-Bo
   Sun, Ping-Liang
   Huang, Hua-Yong
   Liu, Chun-Qiang
   Wei, Mai
TI Efficacy of Vacuum Sealing Drainage after Incision of Perianal Abscess:
   Preliminary Experience
SO AMERICAN SURGEON
LA English
DT Article
C1 [Pang, Li-Ming; Kong, Fan-Biao; Li, De-Gang; Li, Yu-Bo; Sun, Ping-Liang; Huang, Hua-Yong; Liu, Chun-Qiang] Guangxi Univ Chinese Med, Affiliated Hosp 1, Dept Surg, Nanning 530000, Peoples R China.
   [Wang, Xiao-Tong; Wei, Mai] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Gastrointestinal Surg, Nanning, Peoples R China.
   [Wang, Xiao-Tong; Wei, Mai] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Peripheral Vasc Surg, Nanning, Peoples R China.
C3 Guangxi University of Chinese Medicine
RP Liu, CQ (通讯作者)，Guangxi Univ Chinese Med, Affiliated Hosp 1, Dongge Rd 89-9, Nanning 530000, Peoples R China.
EM liuchunqiang0@163.com
RI Fan-Biao, Kong/IQT-2224-2023; Pang, Liming/OIU-1732-2025
FU Natural Science Foundation of China [81360369, 81360545]
FX This work was supported by grants from the Natural Science Foundation of
   China, No. 81360369 & No. 81360545. Science Foundation for Young
   Scientists of Guangxi University of Chinese Medicine (GZYQJ2014013).
CR Liu L, 2012, INT ORTHOP, V36, P1441, DOI 10.1007/s00264-011-1404-6
   Solomon MJ, 1996, INT J COLORECTAL DIS, V11, P222, DOI 10.1007/s003840050051
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   Whiteford Mark H, 2007, Clin Colon Rectal Surg, V20, P102, DOI 10.1055/s-2007-977488
NR 4
TC 7
Z9 11
U1 0
U2 9
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD NOV
PY 2015
VL 81
IS 11
BP E379
EP E382
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DB4BU
UT WOS:000368458500014
PM 26672572
DA 2026-07-24
ER

PT J
AU Lambrechts, MJ
   D'Antonio, ND
   Issa, TZ
   Levy, HA
   Yalla, GR
   Berthiaume, E
   Ciesielka, KA
   Kepler, CK
   Canseco, JA
AF Lambrechts, Mark J.
   D'Antonio, Nicholas D.
   Issa, Tariq Z.
   Levy, Hannah A.
   Yalla, Goutham R.
   Berthiaume, Emily
   Ciesielka, Kerri-Anne
   Kepler, Christopher K.
   Canseco, Jose A.
TI The Usefulness of Closed Incision Negative Pressure Wound Therapy After
   Spinal Fusion: A Systematic Review and Meta-Analysis
SO WORLD NEUROSURGERY
LA English
DT Review
DE Key words-Complications; Meta-analysis; Negative-pressure wound therapy;
   Spine; Surgical site infection; Systematic review; Wound vacuum
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; RISK-FACTORS; SURGERY;
   EXPRESSION; HIP
AB - OBJECTIVE: To determine if closed incision negative pressure wound therapy (ciNPWT) decreases surgical site infection (SSI) or wound dehiscence after spinal fusion. - METHODS: Following PRISMA guidelines, a systematic review and metaanalysis were conducted to identify studies using ciNPWT after spinal fusion. Funnel plots and quality scores of the articles were performed to determine if the articles were at risk of bias. Forest plots were conducted to identify the treatment effect of ciNPWT after spinal fusion. - RESULTS: A total of 8 studies comprising 1061 patients who received ciNPWT or a standard postoperative dressing after spinal fusion were included. The rate of SSI (ciNPWT, 4.49% [95% confidence interval (CI), 2.48-8.00] vs. control, 11.32% [95% CI, 7.51-16.70]; P = 0.0103) was significantly lower for patients treated with ciNPWT. A fixed-effects model showed no significant difference between patients who received ciNWPT or a standard postoperative dressing with respect to requiring reoperations for wound debridement (odds ratio, 1.25; 95% CI, 0.64-2.41). In addition, wound dehiscence was not significantly different between the 2 groups, although it was nonsignificantly lower in ciNWPT-treated patients (ciNPWT, 4.59% [95% CI, 2.49-8.31] vs. control: 7.48% [95% CI, 4.38-12.47]; P = 0.23). - CONCLUSIONS: ciNPWT may reduce the rates of SSI after spinal fusion. The use of ciNWPT may also significantly reduce the burden associated with postoperative wound complications, but the meta-analysis was insufficiently powered to make this association. Additional studies may identify a subset of patients who benefit from ciNPWT for other wound-related complications.
C1 [Lambrechts, Mark J.; D'Antonio, Nicholas D.; Issa, Tariq Z.; Levy, Hannah A.; Yalla, Goutham R.; Berthiaume, Emily; Ciesielka, Kerri-Anne; Kepler, Christopher K.; Canseco, Jose A.] Thomas Jefferson Univ, Rothman Inst, Dept Orthopaed Surg, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Rothman Institute
RP Lambrechts, MJ (通讯作者)，Thomas Jefferson Univ, Rothman Inst, Dept Orthopaed Surg, Philadelphia, PA 19107 USA.
EM mark.lambrechts@rothmanortho.com
RI Canseco, Jose/AAT-1667-2020; lambrechts, mark/ABG-2062-2021
OI lambrechts, mark/0000-0002-9106-2228; Yalla,
   Goutham/0000-0003-0863-2953; Issa, Tariq/0000-0002-0978-5225
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   Wang C, 2019, J ORTHOP SURG RES, V14, DOI 10.1186/s13018-019-1488-z
   Wells GA, 2014, NEWCASTLE OTTAWA SCA
   Xie WW, 2022, INT WOUND J, V19, P1319, DOI 10.1111/iwj.13726
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NR 43
TC 13
Z9 13
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1878-8750
EI 1878-8769
J9 WORLD NEUROSURG
JI World Neurosurg.
PD DEC
PY 2022
VL 168
BP 258
EP +
DI 10.1016/J.WNEU.2022.09.048
PG 11
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 8P3BU
UT WOS:000926401400003
PM 36116727
DA 2026-07-24
ER

PT J
AU McCallon, SK
   Frilot, C
AF McCallon, Stanley K.
   Frilot, Clifton
TI A Retrospective Study of the Effects of Clostridial Collagenase Ointment
   and Negative Pressure Wound Therapy for the Treatment of Chronic
   Pressure Ulcers
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE retrospective study; wound care; chronic pressure ulcer; collagenase;
   negative pressure wound therapy; debridement
ID VACUUM-ASSISTED CLOSURE; BED PREPARATION; DEBRIDEMENT; TRIAL
AB Nonhealing, chronic pressure ulcers present a continuous challenge in the global health care venue, with decreased mobility and the effects of aging on skin placing the elderly at particular risk. Debridement is an important process to decrease risk of infection and promote healing. Enzymatic debridement with, for example, clostridial collagenase ointment (CCO) has been shown to assist with the achievement and maintenance of a clean wound bed in preparation for closure. Negative pressure wound therapy (NPWT) has also been used successfully for the treatment of wounds. Although conclusive research has demonstrated positive independent effects of both CCO and NPWT as treatments for chronic pressure ulcers, there are no known published studies that have investigated the 2 as a conjunctive treatment. Materials and Methods. A retrospective analysis of 114 adult patients was conducted to assess wound healing of chronic pressure ulcers in a setting with medically complex patients. Two groups were established comparing those who received NPWT alone to those who received NPWT plus CCO. The study sample included 67 patients treated with NPWT + CCO and 47 patients who received only NPWT. Results. Results were similar for both treatment groups with mean values indicating the cohorts were closely aligned with respect to wound size, complexity, length of long-term acute care hospital stay, and duration of NPWT. The patients who received NPWT + CCO demonstrated statistically significant changes in several key areas including initial Bates-Jensen Wound Assessment Tool (BWAT) score, changes in the overall BWAT score and in the necrotic tissue domain. Conclusion. Data analysis from this retrospective study indicates patients who received both therapies (NPWT + CCO) demonstrated improved outcomes in speed of debridement and rate of wound closure compared to those who received NPWT alone.
C1 [McCallon, Stanley K.; Frilot, Clifton] LSU Hlth Sci Ctr Shreveport, Shreveport, LA 71103 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport
RP McCallon, SK (通讯作者)，LSU Hlth Sci Ctr Shreveport, Shreveport, LA 71103 USA.
EM smccal@lsuhsc.edu
FU Smith and Nephew Biotherapeutics, Fort Worth, TX
FX This study was funded in part through an unrestricted grant from Smith
   and Nephew Biotherapeutics, Fort Worth, TX. The grantor had no input on
   study design, data collection, or statistical analysis.
CR Alvarez OM, 2002, WOUNDS, V14, P293
   [Anonymous], 2001, Adv Skin Wound Care, V14, P208
   [Anonymous], NPUAP PRESS ULC STAG
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 28
TC 13
Z9 17
U1 0
U2 12
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAR
PY 2015
VL 27
IS 3
BP 44
EP 53
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CD7UA
UT WOS:000351297600002
PM 25786076
DA 2026-07-24
ER

PT J
AU Tingting, S
   Xinyue, F
   Tiantian, Y
   Xiao, A
   Rui, L
   Feng, L
   Daohong, L
   Zhirui, L
   Guoqi, W
AF Tingting, Sun
   Xinyue, Feng
   Tiantian, Yang
   Xiao, An
   Rui, Li
   Feng, Lin
   Daohong, Liu
   Zhirui, Li
   Guoqi, Wang
TI Comparison of the effects of negative pressure wound therapy and
   negative pressure wound therapy with instillation on wound healing in a
   porcine model
SO FRONTIERS IN SURGERY
LA English
DT Article
DE NPWT; instillation; wound healing; staphylococcus aureus; virulence
ID VACUUM-ASSISTED CLOSURE; EXTRACELLULAR ADHERENCE PROTEIN;
   STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; CONJUNCTION; RESPONSES
AB BackgroundNegative pressure wound therapy with instillation (NPWTi) is a novel method based on standard negative pressure wound therapy (NPWT). This study aimed to compare the effects of standard NPWT and NPWTi on bioburden and wound healing in a Staphylococcus aureus (S.aureus) infected porcine model.MethodsGreen fluorescent protein-labeled S.aureus infected wounds were created on the back of porcine. Wounds were treated with NPWT or NPWT with instillation (saline). The tissue specimens were harvested on days 0 (12 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Viable bacterial counts, laser scanning confocal microscopy, PCR, western blot, and histological analysis were performed to assess virulence and wound healing.ResultsThe bacterial count in the NPWTi group was lower than that of the NPWT group and the difference was statistically significant on day 2, day 4, day 6, and day 8 (P < 0.05). The expression levels of agrA, Eap, Spa, and Hla genes of the NPWTi group were significantly lower than that of the NPWT group on day 8 (P < 0.05). The bacterial invasion depth of the NPWTi group was significantly lower than that of the NPWT group on day 2, day 4, day 6, and day 8 (P < 0.05). Though the NPWTi group showed a significantly increased expression of bFGF and VEGF than that of the NPWT group in the early time (P < 0.05), NPWTi cannot lead to better histologic parameters than the NPWT group (P > 0.05).ConclusionOur results demonstrated that NPWTi induced a better decrease in bacterial burden and virulence compared with standard NPWT. These advantages did not result in better histologic parameters on the porcine wound model.
C1 [Tingting, Sun; Xiao, An; Rui, Li; Feng, Lin; Zhirui, Li] Peoples Liberat Army Gen Hosp, Dept Orthopaed, Hainan Hosp Chinese, Sanya, Peoples R China.
   [Xinyue, Feng] Peoples Liberat Army Gen Hosp, Dept Dermatol, Hainan Hosp Chinese, Sanya, Peoples R China.
   [Tiantian, Yang] Wenchang Peoples Hosp, Dept Anesthesiol, Wenchang, Peoples R China.
   [Daohong, Liu] Peoples Liberat Army Gen Hosp, Sr Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.
   [Daohong, Liu] Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.
   [Daohong, Liu; Zhirui, Li; Guoqi, Wang] Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped, Sports Med & Rehabil, Beijing, Peoples R China.
   [Guoqi, Wang] Peoples Liberat Army Gen Hosp, Dept Pediat, Med Ctr Chinese 1, Beijing, Peoples R China.
   [Guoqi, Wang] Chinese Peoples Liberat Army Gen Hosp, Sr Dept Pediat, Seventh Med Ctr, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital;
   Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital
RP Feng, L; Zhirui, L (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthopaed, Hainan Hosp Chinese, Sanya, Peoples R China.; Daohong, L (通讯作者)，Peoples Liberat Army Gen Hosp, Sr Dept Orthoped, Med Ctr 4, Beijing, Peoples R China.; Daohong, L (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Orthoped, Med Ctr 8, Beijing, Peoples R China.; Daohong, L; Zhirui, L; Guoqi, W (通讯作者)，Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped, Sports Med & Rehabil, Beijing, Peoples R China.; Guoqi, W (通讯作者)，Peoples Liberat Army Gen Hosp, Dept Pediat, Med Ctr Chinese 1, Beijing, Peoples R China.; Guoqi, W (通讯作者)，Chinese Peoples Liberat Army Gen Hosp, Sr Dept Pediat, Seventh Med Ctr, Beijing, Peoples R China.
EM guoqi71@126.com; lzr860514@163.com; 13810085005@139.com;
   lyf1011@aliyun.com
FU Hainan Province Clinical Medical Center; projects of military logistics
   research foundation [AWS17J004]
FX This research is supported by Hainan Province Clinical Medical Center
   and the projects of military logistics research foundation (No.
   AWS17J004) to ZL.
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NR 38
TC 3
Z9 4
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD APR 17
PY 2023
VL 10
AR 1080838
DI 10.3389/fsurg.2023.1080838
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA E9JW8
UT WOS:000978629200001
PM 37139193
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nangole, FW
   Agak, G
AF Nangole, Ferdinand Wanjala
   Agak, George
TI The effects of negative pressure wound therapy on wounds with
   cerebrospinal fluid leakages
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; NPWT; wounds with CSF leakage; wound;
   wound care; wound healing
ID VACUUM-ASSISTED CLOSURE; MECHANISM; HYPOXIA
AB Objective: Negative pressure wound therapy (NPWT) has been widely used for a variety of wounds with good outcomes. However, it is contraindicated in the management of wounds with cerebrospinal fluid (CSF) leakages. The reason is the fear of a sudden shift of CSF fluid as a result of suction leading to brain herniation or coning. There is a paucity of data to either support or negate such claims. We aimed to determine the effect of NPWT in the management of patients with wounds with CSF leakages.
   Method: This was a longitudinal prospective study of patients having wounds with CSF leakages managed with NPWT in our institute. Outcome measures evaluated were changes in the level of consciousness, Glasgow Coma Scale (GCS) score, length of hospital stay, mean effluent collected, time taken for the wounds to heal/close and complications related to NPWT.
   Results: A total of 12 patients with wounds that had CSF leakage were managed with NPWT over two years. Of the patients, nine had wounds in communication with the brain, with three patients having spinal cord wounds. The average effluent collected on the first day of applying NPWT was 510ml, and by the third day this had fallen to approximately 200ml. The mean time taken for wounds to close was 12.3 days. There was no evidence of herniation nor any other morbidities or mortalities reported in any of our patients.
   Conclusion: NPWT, as indicated in this series, had a beneficial effect in the management of wounds with CSF leakage. NPWT, once applied to the wound, caused a tamponade effect that resulted in stoppage of the leakage of the CSF and did not lead to suction of the fluid, as previously thought. The dressings ensured an airtight system, preventing communication between the wound and the external environment, thus reducing sepsis while awaiting definitive wound closure.
C1 [Nangole, Ferdinand Wanjala] Univ Nairobi, Dept Surg, POB 30197, Nairobi, Kenya.
   [Agak, George] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA.
C3 University of Nairobi; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA
RP Nangole, FW (通讯作者)，Univ Nairobi, Dept Surg, POB 30197, Nairobi, Kenya.
EM nangole2212@gmail.com
RI Agak, George/AAN-2246-2021
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NR 20
TC 2
Z9 2
U1 0
U2 5
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD APR
PY 2022
VL 31
IS 4
BP 348
EP 351
DI 10.12968/jowc.2022.31.4.348
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0L6QX
UT WOS:000781598300009
PM 35404701
DA 2026-07-24
ER

PT J
AU Kairinos, N
   Solomons, M
   Hudson, DA
AF Kairinos, Nicolas
   Solomons, Michael
   Hudson, Donald A.
TI The paradox of negative pressure wound therapy - in vitro studies
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article; Proceedings Paper
CT 37th Annual Congress of the
   South-African-Society-for-Surgery-to-the-Hand
CY SEP 04-05, 2006
CL Durban, SOUTH AFRICA
SP S African Soc Surg Hand
DE Negative-pressure wound therapy; Topical negative pressure; Vacuum
   dressings; Suction dressings; VAC; Tissue pressure
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; BLOOD-FLOW
AB Negative-pressure wound therapy (NPWT) has revolutionised wound care. Yet, it is still not understood how hypobaric tissue pressure accelerates wound healing. There is very little reported on the relevant physics of any substance subjected to suction in this manner. The common assumption is that applying suction to a substance is likely to result in a reduction of pressure in that substance. Although more than 250 research articles have been published on NPWT, there are little data verifying whether suction increases or decreases the pressure of the substance it is applied to. Clarifying this basic question of physics is the first step in understanding the mechanism of action of these dressings.
   In this study, pressure changes were recorded in soft plasticene and processed meat, using an intracranial tissue pressure microsensor. Circumferential, non-circumferential and cavity NPWT dressings were applied, and pressure changes within the underlying substance were recorded at different suction pressures. Pressures were also measured at 1 cm, 2 cm and 3 cm from the NPWT placed in a cavity.
   In all three types of NPWT dressings, the underlying substance pressure was increased (hyperbaric) as suction pressure increased. Although there was a substantial pressure increase at 1 cm, the rise in pressure at the 2-cm and 3-cm intervals was minimal.
   Substance pressure beneath all types of NPWT dressing is hyperbaric in inanimate substances. Higher suction pressures generate greater substance pressures; however, the increased pressure rapidly dissipates as the distance from the dressing is increased. The findings of this study on inanimate objects suggest that we may need to review our current perception of the physics underlying NPWT dressings. Further research of this type on living tissues is warranted. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, ZA-7700 Rondebosch, South Africa.
C3 University of Cape Town; University of Cape Town
RP Kairinos, N (通讯作者)，Groote Schuur Hosp, Dept Plast Surg, H53 Old Main Bldg,Main Rd, ZA-7925 Cape Town, South Africa.
EM nickykairinos@gmail.com
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Chen Shao-Zong, 2005, Asian J Surg, V28, P211, DOI 10.1016/S1015-9584(09)60346-8
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   Kamolz LP, 2004, BURNS, V30, P253, DOI 10.1016/j.burns.2003.12.003
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NR 12
TC 74
Z9 85
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD JAN
PY 2010
VL 63
IS 1
BP 174
EP 179
DI 10.1016/j.bjps.2008.08.037
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 536YA
UT WOS:000273078600028
PM 19036656
DA 2026-07-24
ER

PT J
AU Runkel, N
   Krug, E
   Berg, L
   Lee, C
   Hudson, D
   Birke-Sorensen, H
   Depoorter, M
   Dunn, R
   Jeffery, S
   Duteille, F
   Bruhin, A
   Caravaggi, C
   Chariker, M
   Dowsett, C
   Ferreira, F
   Martínez, JMF
   Grudzien, G
   Ichioka, S
   Ingemansson, R
   Malmsjo, M
   Rome, P
   Vig, S
   Martin, R
   Smith, J
AF Runkel, N.
   Krug, E.
   Berg, L.
   Lee, C.
   Hudson, D.
   Birke-Sorensen, H.
   Depoorter, M.
   Dunn, R.
   Jeffery, S.
   Duteille, F.
   Bruhin, A.
   Caravaggi, C.
   Chariker, M.
   Dowsett, C.
   Ferreira, F.
   Francos Martinez, J. M.
   Grudzien, G.
   Ichioka, S.
   Ingemansson, R.
   Malmsjo, M.
   Rome, P.
   Vig, S.
   Martin, R.
   Smith, J.
CA Int Expert Panel Negative Pressure
TI Evidence-based recommendations for the use of Negative Pressure Wound
   Therapy in traumatic wounds and reconstructive surgery: Steps towards an
   international consensus
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Consensus; Recommendations;
   Systematic review; Traumatic wounds; Reconstructive closure
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; THICKNESS SKIN-GRAFTS;
   SEVERE OPEN FRACTURES; FOREARM DONOR SITE; SUBATMOSPHERIC PRESSURE;
   CLINICAL-EXPERIENCE; LOWER-LIMBS; PEDIATRIC-PATIENTS; CONTROLLED-TRIAL
AB Negative pressure wound therapy (NPWT) has become widely adopted over the last 15 years and over 1000 peer reviewed publications are available describing its use. Despite this, there remains uncertainty regarding several aspects of usage. In order to respond to this gap a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In this paper the results of the study of evidence in traumatic wounds (including soft tissue defects, open fractures and burns) and reconstructive procedures (including flaps and grafts) are reported. Evidence-based recommendations were obtained by a systematic review of the literature, grading of evidence, drafting of the recommendations by a global expert panel, followed by a formal consultative consensus development program in which 422 independent healthcare professionals were able to agree or disagree with the recommendations. The criteria for agreement were set at 80% approval. Evidence and recommendations were graded according to the SIGN (Scottish Intercollegiate Guidelines Network) classification system. Twelve recommendations were developed in total; 4 for soft tissue trauma and open fracture injuries, 1 for burn injuries, 3 for flaps and 4 for skin grafts. The present evidence base is strongest for the use of NPWT on skin grafts and weakest as a primary treatment for burns. In the consultative process, 11/12 of the proposed recommendations reached the 80% agreement threshold. The development of evidence-based recommendations for NPWT with direct validation from a large group of practicing clinicians offers a broader basis for consensus than work by an expert panel alone. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen, Germany.
   [Runkel, N.] Univ Freiburg, D-7800 Freiburg, Germany.
   [Krug, E.] Leiden Univ, Med Ctr, NL-2300 RA Leiden, Netherlands.
   [Berg, L.] Kuopio Univ Hosp, Kuopio, Finland.
   [Lee, C.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lee, C.] St Marys Hosp, San Francisco, CA USA.
   [Hudson, D.] Groote Schuur Hosp, Dept Plast & Reconstruct Surg, ZA-7925 Cape Town, South Africa.
   [Birke-Sorensen, H.] Hamlet Hosp, Aarhus, Denmark.
   [Depoorter, M.] Acad Hosp St Jan, Dept Plast & Reconstruct Surg, Brugge, Belgium.
   [Dunn, R.] Univ Massachusetts, Div Plast Surg, Sch Med, Worcester, MA 01605 USA.
   [Dunn, R.] Mem Hlth Care, Worcester, MA USA.
   [Jeffery, S.] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham B15 2TH, W Midlands, England.
   [Duteille, F.] Hop Hotel Dieu, Aesthet & Reconstruct Surg Burn Unit, Nantes, France.
   [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Caravaggi, C.] Inst Clin Citta Studi, Ctr Treatment Diabet Foot Pathol, Milan, Italy.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Francos Martinez, J. M.] Hosp Univ Bellvitge, Endocrine Surg Unit, Barcelona, Spain.
   [Grudzien, G.] John Paul 2 Hosp, Dept Cardiovasc Surg & Transplantol, Krakow, Poland.
   [Ichioka, S.] Saitama Med Univ, Dept Plast & Reconstruct Surg, Saitama, Japan.
   [Ingemansson, R.] Univ Lund Hosp, Heart & Lung Div, Dept Cardiothorac Surg, Lund, Sweden.
   [Malmsjo, M.] Lund Univ, Dept Ophthalmol, Lund, Sweden.
   [Malmsjo, M.] Skane Univ Hosp, Lund, Sweden.
   [Rome, P.] Royal Prince Alfred Hosp, Sydney, NSW, Australia.
   [Rome, P.] Concord Hosp, Sydney, NSW, Australia.
   [Vig, S.] Mayday Univ Hosp, London, England.
   [Martin, R.; Smith, J.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
C3 University of Freiburg; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; University of Eastern
   Finland; University of Eastern Finland Hospital; Kuopio University
   Hospital; University of California System; University of California San
   Francisco; University of Cape Town; University of Massachusetts System;
   University of Massachusetts Worcester; Royal Centre for Defence
   Medicine; University of Birmingham; Nantes Universite; CHU de Nantes;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Saitama Medical
   University; Lund University; Skane University Hospital; Lund University;
   Lund University; Skane University Hospital; University of Sydney; NSW
   Health; Royal Prince Alfred Hospital; Concord Repatriation General
   Hospital; Croydon University Hospital; Smith & Nephew
RP Runkel, N (通讯作者)，Postfach 2103, D-78011 Villingen Schwenningen, Germany.
EM norbert.runkel@sbk-vs.de
RI Birke-Sørensen, Hanne/B-6733-2015; jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412; Ingemansson,
   Richard/0000-0001-7623-8953; Martin, Robin/0000-0002-9314-0437; Maljö,
   Malin/0000-0001-9849-9599
FU Smith Nephew
FX Smith & Nephew provided funding for travel and accommodation for all
   face-to-face expert panel meetings, provided support regarding the
   published literature in NPWT, arranged and provided funding for the
   'consultative phase' of the project (a symposium to 422 Healthcare
   professionals in Hamburg Feb 2010), provided support during the drafting
   of recommendations (authors Jenny Smith and Robin Martin) and provided
   medical writing services in preparation of this manuscript (author Jenny
   Smith). The recommendations reflect the independent and unbiased views
   of the panel and the consensus derived during the project and the
   content of the manuscript has not been unfairly influenced by Smith &
   Nephew.
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NR 90
TC 136
Z9 165
U1 0
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
J9 INJURY
JI Injury-Int. J. Care Inj.
PD FEB
PY 2011
VL 42
SU 1
BP S1
EP S12
DI 10.1016/S0020-1383(11)00041-6
PG 12
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 720UU
UT WOS:000287308900001
PM 21316515
DA 2026-07-24
ER

PT J
AU Stannard, JP
   Volgas, DA
   McGwin, G
   Stewart, RL
   Obremskey, W
   Moore, T
   Anglen, JO
AF Stannard, James P.
   Volgas, David A.
   McGwin, Gerald, III
   Stewart, Rena L.
   Obremskey, William
   Moore, Thomas
   Anglen, Jeffrey O.
TI Incisional Negative Pressure Wound Therapy After High-Risk Lower
   Extremity Fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article; Proceedings Paper
CT 23rd Annual Meeting of the Orthopaedic-Trauma-Association
CY OCT 17-20, 2007
CL Boston, MA
SP Orthopaed Trauma Assoc
DE negative pressure wound therapy; lower extremity trauma; wound
   dehiscence and infection; tibial plateau fractures; pilon fractures;
   calcaneus fractures
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; PERISTERNAL THORACIC
   WALL; TIBIAL PILON FRACTURES; INTERNAL-FIXATION; BLOOD-FLOW; TEMPORARY
   TREATMENT; OPEN REDUCTION; MANAGEMENT; COMPLICATIONS
AB Objectives: To investigate negative pressure wound therapy (NPWT) to prevent wound dehiscence and infection after high-risk lower extremity trauma.
   Design: Prospective randomized multicenter clinical trial.
   Setting: Four Level I trauma centers.
   Patients/Participants: Blunt trauma patients with one of three high-risk fracture types (tibial plateau, pilon, calcaneus) requiring surgical stabilization.
   Intervention: Incisional NPWT (Group B) was applied to the closed surgical incisions of patients randomized to the study arm of this trial, whereas standard postoperative dressings (Group A) were applied to the control patients.
   Main Outcome Measures: Acute and chronic wound dehiscence and infection.
   Results: Two hundred forty-nine patients with 263 fractures have enrolled in this study with 122 randomized to Group A (controls) and 141 to Group B (NPWT). There was no difference between the groups in the distribution of calcaneus (39%), pilon (17%), or tibial plateau (44%) fractures. There were a total of 23 infections in Group A and 14 in Group B, which represented a significant difference in favor of NPWT (P = 0.049). The relative risk of developing an infection was 1.9 times higher in control patients than in patients treated with NPWT (95% confidence interval, 1.03-3.55).
   Conclusions: There have been no studies evaluating incisional NPWT as a prophylactic treatment to prevent infection and wound dehiscence of high-risk surgical incisions. Our data demonstrate that there is a decreased incidence of wound dehiscence and total infections after high-risk fractures when patients have NPWT applied to their surgical incisions after closure. There is also a strong trend for decreases in acute infections after NPWT. Based on our data in this multicenter prospective randomized clinical trial, NPWT should be considered for high-risk wounds after severe skeletal trauma.
C1 [Stannard, James P.] Univ Missouri, Dept Orthopaed, Columbia, MO 65212 USA.
   [McGwin, Gerald, III] Univ Alabama Birmingham, Callahan Eye Fdn Hosp 609, Birmingham, AL USA.
   [Obremskey, William] Vanderbilt Orthopaed Inst, Nashville, TN USA.
   [Moore, Thomas] Emory Univ, Sch Med, Atlanta, GA USA.
   [Anglen, Jeffrey O.] Indiana Univ, Med Ctr, Indianapolis, IN USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Alabama System; University of Alabama Birmingham;
   Vanderbilt University; Emory University; Indiana University System;
   Indiana University Indianapolis
RP Stannard, JP (通讯作者)，Univ Missouri, Dept Orthopaed, 1 Hosp Dr,MC213,DC053-00, Columbia, MO 65212 USA.
EM StannardJ@health.missouri.edu
RI ; Obremskey, William/HRA-4704-2023
OI Anglen, Jeffrey/0000-0001-9910-6611; Stannard, James
   P/0000-0001-8467-6494; Obremskey, William/0000-0002-8942-1842
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NR 41
TC 291
Z9 338
U1 2
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2012
VL 26
IS 1
BP 37
EP 42
DI 10.1097/BOT.0b013e318216b1e5
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Sport Sciences
GA 868UO
UT WOS:000298551600009
PM 21804414
DA 2026-07-24
ER

PT J
AU Kairinos, N
   Holmes, WJM
   Solomons, M
   Hudson, DA
   Kahn, D
AF Kairinos, Nicolas
   Holmes, William J. M.
   Solomons, Michael
   Hudson, Donald A.
   Kahn, Delawir
TI Does a Zone of Increased Perfusion Exist around Negative-Pressure
   Dressings?
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PERISTERNAL THORACIC WALL; MICROVASCULAR
   BLOOD-FLOW; LASER-DOPPLER FLOWMETRY; WOUND-THERAPY; INTERMITTENT;
   RESPONSES
AB Background: Although recent work has demonstrated that perfusion adjacent to a negative-pressure wound therapy dressing is decreased, laser Doppler studies have indicated that there is a zone of increased perfusion a couple of centimeters away. The existence of such a zone of increased perfusion is counterintuitive to the fact that negative-pressure wound therapy has been shown to increase tissue pressure. This study, using an alternative to laser Doppler, evaluated whether such a zone exists.
   Methods: Six volunteers were randomized into three groups to test different suction pressures (-75, -125, and -400 mmHg). Each volunteer would have two dressings applied on either side of the lower back. A thermal imaging camera was used to assess perfusion around the dressing during different phases (e.g., Suction on and Suction off). The mean area under the curve for each phase was compared with those of other phases by means of one-way analysis of variance. Each condition (phase) was compared in a systematic manner with every other by means of Fisher's least significant difference for post hoc comparisons. A Pearson's correlation was determined to test the effects of the different suction pressure groups.
   Results: No significant difference could be demonstrated for the area under the curve for the different phases. There was no significant correlation between the three suction pressures tested and the difference between the mean area under the curve for Dressing on, no suction and the two Suction on periods (Pearson correlation = 0.24; p > 0.4).
   Conclusions: Thermographic evaluation of tissue around a negative-pressure dressing did not demonstrate a zone of increased perfusion, contrary to other studies, which used laser Doppler. This is in keeping with recent work demonstrating that negative-pressure wound therapy increases tissue pressure while the dressing is applying suction.
   CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
C1 Univ Cape Town, Dept Plast Surg, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Orthopaed Surg, Martin Singer Hand Unit, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Dept Surg, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, ZA-7925 Cape Town, South Africa.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town; University of Cape Town
RP Kairinos, N (通讯作者)，5 Pipit Lane,Century Dr, ZA-7441 Cape Town, South Africa.
EM nickykairinos@gmail.com
FU Department of Surgery, Groote Schuur Hospital, Cape Town; Kinetic
   Concepts Inc., South Africa; Thermal Health Solutions, South Africa
FX The authors have no financial disclosures or conflicts of interest to
   declare. This study was funded by the Department of Surgery, Groote
   Schuur Hospital, Cape Town. The Vacuum-Assisted Closure dressings were
   sponsored by Kinetic Concepts Inc., South Africa. The thermal image
   camera was sponsored by Thermal Health Solutions, South Africa.
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NR 38
TC 23
Z9 26
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2013
VL 132
IS 4
BP 978
EP 987
DI 10.1097/PRS.0b013e31829f4ad9
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 290ZE
UT WOS:000329796500079
PM 23783056
DA 2026-07-24
ER

PT J
AU Liu, DSH
   Sofiadellis, F
   Ashton, M
   MacGill, K
   Webb, A
AF Liu, David Shi Hao
   Sofiadellis, Foti
   Ashton, Mark
   MacGill, Kirstie
   Webb, Angela
TI Early soft tissue coverage and negative pressure wound therapy optimises
   patient outcomes in lower limb trauma
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Flap; Reconstruction; Trauma; Time; Negative Pressure Wound Therapy;
   Lower Limb
ID SEVERE OPEN FRACTURES; VACUUM-ASSISTED CLOSURE; TIBIAL SHAFT;
   RECONSTRUCTION; FLAP; MANAGEMENT; EXPERIENCE
AB Background: The timing of soft tissue reconstruction for severe open lower limb trauma is critical to its successful outcome, particularly in the setting of exposed metalware and pre-existing wound infection. The use of negative pressure wound therapy (NPWT) may allow a delay in soft tissue coverage without adverse effects. This study evaluated the impact of delayed free-flap reconstruction, prolonged metalware exposure, pre-flap wound infection, and the efficacy of NPWT on the success of soft tissue coverage after open lower limb injury.
   Methods: Retrospective review of all free-flap reconstructions for lower limb trauma undertaken at a tertiary trauma centre between June 2002 and July 2009.
   Results: 103 patients underwent 105 free-flap reconstructions. Compared with patients who were reconstructed within 3 days of injury, the cohort with delayed reconstruction beyond 7 days had significantly increased rates of pre-flap wound infection, flap re-operation, deep metal infection and osteomyelitis. Pre-flap wound infection independently predicted adverse surgical outcomes. In the setting of exposed metalware, free-flap transfer beyond one day significantly increased the flap failure rate. These patients required more surgical procedures and a longer hospital stay. The use of NPWT significantly lowered the rate of flap re-operations and venous thrombosis, but did not allow a delay in reconstruction beyond 7 days from injury without a concomitant rise in skeletal and flap complications.
   Conclusions: Following open lower limb trauma, soft tissue coverage within 3 days of injury and immediately following fracture fixation with exposed metalware minimises pre-flap wound infection and optimises surgical outcomes. NPWT provides effective temporary wound coverage, but does not allow a delay in definitive free-flap reconstruction. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Liu, David Shi Hao; Sofiadellis, Foti; Ashton, Mark; MacGill, Kirstie; Webb, Angela] Royal Melbourne Hosp, Dept Plast & Reconstruct Surg, Parkville, Vic 3050, Australia.
C3 Melbourne Health; Royal Melbourne Hospital
RP Liu, DSH (通讯作者)，Royal Melbourne Hosp, Dept Plast & Reconstruct Surg, Level 7,Grattan St, Parkville, Vic 3050, Australia.
EM dshliu@bigpond.com; fsofia@gmail.com; mwashton@iimetro.com.au;
   kmacgill@optusnet.com.au; dr.a.webb@gmail.com
OI Webb, Angela/0000-0002-0659-8029
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NR 25
TC 92
Z9 112
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUN
PY 2012
VL 43
IS 6
BP 772
EP 778
DI 10.1016/j.injury.2011.09.003
PG 7
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA 942LI
UT WOS:000304045100016
PM 22001504
DA 2026-07-24
ER

PT J
AU Lim, K
   Lim, X
   Hong, QT
   Yong, E
   Chandrasekar, S
   Tan, GWL
   Lo, ZWJ
AF Lim, Kai
   Lim, Xuxin
   Hong, Qiantai
   Yong, Enming
   Chandrasekar, Sadhana
   Tan, Glenn W. L.
   Lo, Zhiwen J.
TI Use of home negative pressure wound therapy in peripheral artery disease
   and diabetic limb salvage
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE critical limb ischaemia; diabetic limb salvage; negative pressure wound
   therapy; peripheral arterial disease
ID VACUUM-ASSISTED CLOSURE; AMPUTATIONS; CARE; MULTICENTER; PREDICTORS
AB Use of negative pressure wound therapy (NPWT) in peripheral artery disease (PAD) and diabetic limb salvage (DLS) improves wound healing by providing moist wound conditions, reducing exudate, controlling wound-bed infection, and stimulating granulation. NPWT duration may take several weeks, and home-based NPWT allows patient to recover in the community while minimising risks of prolonged hospitalisation. The aim of this study is to review the use and outcomes of home NPWT in PAD and DLS. The methodology is the retrospective review of patients who were discharged with home NPWT after in-patient PAD revascularisation and DLS debridement or minor amputations. The results included a total of 118 patients who received home NPWT between January 2017 and December 2017. The mean age was 62.8 years with 66% male and 34% female patients. The study population comprised 25% smokers, 98% patients with diabetics, 35% with ischemic heart disease, and 21% with end-stage renal failure (ESRF). Of which, 56% of patients required revascularisation while 31% of patients underwent foot debridement, 48% underwent toe amputations, and 20% underwent forefoot amputations. All patients received in-patient NPWT for a week before being discharged on home NPWT for 4 weeks. Then, 62% received targeted antibiotics regime while 36% received empirical antibiotics on discharge; 60% of patients achieved wound healing on home NPWT, with 9% requiring split-thickness skin graft; 4% required further surgical debridement, 16% required further minor amputation while 20% required major amputation. 9% required further home NPWT extension, with a mean length of 7.1 +/- 4.7 weeks' extension. Overall survival of 1 year was 89%. Risk factors that predict the failure of home NPWT includes subjects with a background of ESRF and wet gangrene on presentation. Home NPWT is a useful adjunct in the management of PAD and DLS foot wounds.
C1 [Lim, Kai; Lim, Xuxin; Hong, Qiantai; Yong, Enming; Chandrasekar, Sadhana; Tan, Glenn W. L.; Lo, Zhiwen J.] Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
C3 Tan Tock Seng Hospital
RP Lo, ZWJ (通讯作者)，Tan Tock Seng Hosp, Dept Gen Surg, Vasc Surg Serv, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
EM zhiwen_lo@ttsh.com.sg
RI ; Yong, Enming/LXB-4566-2024
OI LO, ZHIWEN JOSEPH/0000-0003-2289-5266; Chanasekar,
   Sadhana/0000-0002-3650-8020; Hong, Qiantai/0000-0003-1334-7049; Yong,
   Enming/0000-0002-9461-0066
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NR 37
TC 9
Z9 11
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2020
VL 17
IS 3
BP 531
EP 539
DI 10.1111/iwj.13307
EA JAN 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA LH4PB
UT WOS:000508801200001
PM 31972901
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Dedmond, BT
   Kortesis, B
   Punger, K
   Simpson, J
   Argenta, J
   Kulp, B
   Morykwas, M
   Webb, LX
AF Dedmond, Barnaby T.
   Kortesis, Bill
   Punger, Kathleen
   Simpson, Jordan
   Argenta, Joseph
   Kulp, Brenda
   Morykwas, Michael
   Webb, Lawrence X.
TI The use of negative-pressure wound therapy (NPWT) in the temporary
   treatment of soft-tissue injuries associated with high-energy open
   tibial shaft fractures
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE tibia fractures; open fractures; Wound VAC; negative-pressure wound
   therapy
ID VACUUM-ASSISTED CLOSURE; INTRAMEDULLARY NAILS; ANTIBIOTIC-THERAPY;
   RECONSTRUCTION; CLASSIFICATION; INFECTION; UNION; RATES; LEG
AB Objectives: To evaluate the utility of negative-pressure wound therapy (NPWT) in the setting of high-energy open tibial shaft fractures.
   Design, Setting, and Patients/Participants: This was a retrospective consecutive series in a level 1 university-based trauma center. Forty-nine consecutive patients presenting to a level 1 trauma center between 1996 and 2004 with 50 grade/type III open tibial shaft fractures were assessed.
   Intervention: The open wounds associated with each fracture were each treated with NPWT before definitive wound closure or coverage.
   Main Outcome Measurements: Infection rate, need for amputation after attempted definitive coverage, problems with bony healing requiring surgical intervention, reoperation rate after definitive coverage, and the type of definitive coverage required.
   Results: The overall infection rate for all grade/type III open fractures was 15 of 50 fractures (30%), with 11 of 50 (22%) requiring repeated surgery for infection. The infection rate was 12.5% for grade/type IIIA open fractures, 45.8% for grade/type IIIB, and 50% for grade/type IIIC. Twenty-four of 50 fractures (48%) required subsequent surgery to facilitate fracture healing. Five fractures required amputation after attempted coverage. Seven of 24 fractures initially classified as grade/type IIIA and 10 of 24 fractures initially classified as grade/type IIIB ultimately required free tissue transfer or rotational muscle flap coverage.
   Conclusions: Infection and nonunion rates with the use of NPWT for temporary coverage of wounds associated with grade/type III open tibial shaft fractures are similar to those of historical controls, but this technique may be beneficial in decreasing the need for free tissue transfer or rotational muscle flap coverage.
C1 Lexington Orthoped, W Columbia, SC 29169 USA.
   Wake Forest Univ, Dept Plast Surg, Winston Salem, NC USA.
   Wake Forest Univ, Dept Orthopaed Surg, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest University
RP Dedmond, BT (通讯作者)，Lexington Orthoped, 110 E Med Lane,Suite 220-235, W Columbia, SC 29169 USA.
EM dedmoba@yahoo.com
OI Morykwas, Michael/0009-0001-5547-5172
CR Alberts KA, 1999, INJURY, V30, P519, DOI 10.1016/S0020-1383(99)00143-6
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NR 22
TC 109
Z9 138
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD JAN
PY 2007
VL 21
IS 1
BP 11
EP 17
DI 10.1097/BOT.0b013e31802cbc54
PG 7
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 127SK
UT WOS:000243606400003
PM 17211263
DA 2026-07-24
ER

PT J
AU Di Micco, R
   Santurro, L
   Zuber, V
   Gasparri, ML
   Cisternino, G
   Ludovica, P
   Ceccarino, R
   Rottino, SA
   Forma, O
   Gentilini, OD
AF Di Micco, Rosa
   Santurro, Letizia
   Zuber, Veronica
   Gasparri, Maria Luisa
   Cisternino, Giovanni
   Ludovica, Pitoni
   Ceccarino, Raffaele
   Rottino, Stefano Antonio
   Forma, Ornella
   Gentilini, Oreste D.
TI Implant infection after prepectoral breast reconstruction treated with
   negative pressure wound therapy and photobiomodulation: a case report
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE breast implant; ductal breast carcinoma; infection; mastectomy; negative
   pressure wound therapy; photobiomodulation; prepectoral breast
   reconstruction; wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; COMPLICATIONS; MANAGEMENT; SURGERY; SALVAGE;
   BIOMODULATION; METAANALYSIS; EFFICACY; DEVICE; REPAIR
AB Prepectoral breast reconstruction is a relatively new surgical technique that allows placement of the implant directly over the pectoralis major. It has benefits in terms of patient wellbeing, operative time, postoperative pain and recovery. However, in cases of infection, implant removal is often required and the patient is left with a flat chest. To the authors' knowledge, this is the first case of breast implant infection after breast reconstruction, successfully treated with a combination of both negative pressure wound therapy (NPWT) and photobiomodulation (PBM). A 32-year-old female patient with a sparing mastectomy for in situ ductal breast carcinoma followed by a prepectoral reconstruction. On the left side, the patient presented with dehiscence of 2.5cm with implant exposure 90 days after surgery. After an initial conservative approach, the patient's condition worsened, and she developed a larger dehiscence and a red breast. She was treated with implant removal. PBM of the cavity and the application of VeraFlo Therapy (3M, US) with a polyurethane-foam filling in the residual cavity were adopted. Pseudomonas aeruginosa was isolated and appropriate antibiotic therapy was started. Every 48-72 hours, she returned to the operating room for a washout, PBM, 21 days of this approach and two consecutive negative swabs, the patient underwent breast reconstruction with a subpectoral expander. After six months, a definitive implant of the same size as the contralateral one was positioned. The cosmetic result was good and patient satisfaction was high. The combination of NPWT and PBM may represent a good solution in case of breast implant infection after prepectoral reconstruction with benefits in terms of surgical outcome, patient satisfaction and postoperative quality of life. Declaration of interest: The authors have no conflicts of interest.
C1 [Di Micco, Rosa; Santurro, Letizia; Zuber, Veronica; Gasparri, Maria Luisa; Cisternino, Giovanni; Ludovica, Pitoni; Ceccarino, Raffaele; Rottino, Stefano Antonio; Gentilini, Oreste D.] IRCCS Osped San Raffaele, Breast Surg Unit, Milan, Italy.
   [Santurro, Letizia] Human Gavazzeni, Breast Surg, Via Mauro Gavazzeni Bergamo, Bergamo, Italy.
   [Gasparri, Maria Luisa] Ctr Senol Svizzera Italiana, Dept Gynecol & Obstet, Ente Ospedaliero Cantonale, Lugano, Switzerland.
   [Gasparri, Maria Luisa] Univ Italian Switzerland, Fac Biomed, Lugano, Switzerland.
   [Forma, Ornella] IRCCS Osped San Raffaele, Wound Care Unit, Milan, Italy.
   [Gentilini, Oreste D.] San Raffaele Vita Salute Univ, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Universita della Svizzera Italiana; Vita-Salute San Raffaele University;
   IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University
RP Di Micco, R (通讯作者)，IRCCS Osped San Raffaele, Breast Surg Unit, Milan, Italy.
EM dimicco.rosa@hsr.it
RI ; Di Micco, Rosa/AAC-3067-2019; Gentilini, Oreste/AAN-7577-2020
OI Pitoni, Ludovica/0000-0001-8462-8695; GASPARRI, Maria
   Luisa/0000-0002-9482-9527; 
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NR 55
TC 0
Z9 0
U1 1
U2 2
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD MAR
PY 2025
VL 34
IS 3
BP 180
EP 186
DI 10.12968/jowc.2022.0097
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Z9H4H
UT WOS:001441927700003
PM 40047824
DA 2026-07-24
ER

PT J
AU Allen, D
   Mann, S
   Robinson, T
   Schmidt, M
   Kieswetter, K
AF Allen, Diwi
   Mann, Samantha
   Robinson, Timothy
   Schmidt, Marisa
   Kieswetter, Kristine
TI Preclinical Assessments of a Novel Peel and Place Extended-Wear
   Negative-Pressure Wound Therapy Dressing for up to 35 Days in a Porcine
   Model
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure wound therapy; NPWT; negative pressure therapy; NPT;
   reticulated open cell foam; ROCF; wounds; wound healing; porcine model;
   swine; long-term wear dressing; extended wear dressing
ID VACUUM-ASSISTED CLOSURE; SUBATMOSPHERIC PRESSURE; PROGRESSION; MECHANISM
AB Objective: While the use of negative pressure wound therapy (NPWT) with reticulated open cell foam (ROCF) is well established, the characteristics of ROCF do not allow for extended-wear use. There is the potential for dressing tissue ingrowth if left in place for greater than the recommended 2-3 days. An easy to use, novel peel and place dressing has been designed for extended wear with the wound management advantages of ROCF while alleviating the challenges of tissue ingrowth.Approach: Paraspinal, full-thickness or deep muscle excisional wounds were created in 11 and 2 swine, respectively, dressings applied with continuous negative pressure at -125 mmHg, and dressings changed weekly. Full-thickness excisional wounds were treated for 13 days and deep muscle wounds for 35 days. Wound dimensions were assessed. Granulation tissue thickness and re-epithelialization were measured via digital morphometry. Tissue quality, fibrinous material prevalence, and dressing removal peel force were analyzed.Results: The peel and place dressing substantially reduces dressing tissue ingrowth, is easy to remove with markedly low dressing peel force and promotes more granulation tissue at day 13 than ROCF with an interface layer. The extended-wear peel and place dressing, when applied to deep muscle wounds with weekly dressing changes, was applied for a total of 35 days. Successful wound closure was evident without any negative impact on wound healing.Innovation: This study assessed the wound management capabilities of an extended-wear peel and place NPWT dressing used until wound closure.Conclusion: The peel and place dressing is a suitable extended-wear NPWT dressing.
C1 [Allen, Diwi; Mann, Samantha; Robinson, Timothy; Schmidt, Marisa; Kieswetter, Kristine] 3M Hlth Care, Med Solut Div, San Antonio, TX 78249 USA.
C3 3M
RP Allen, D (通讯作者)，3M Hlth Care, Med Solut Div, San Antonio, TX 78249 USA.
EM dlallen@solventum.com
FU The 3M Health Care
FX Financial support was provided by 3M Health Care.
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   Saxena V, 2004, PLAST RECONSTR SURG, V114, P1086, DOI 10.1097/01.prs.0000135330.51408.97
   Scherer SS, 2008, PLAST RECONSTR SURG, V122, P786, DOI 10.1097/PRS.0b013e31818237ac
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   Shweiki E, 2013, INT WOUND J, V10, P13, DOI 10.1111/j.1742-481X.2012.00940.x
   Vig S, 2011, J TISSUE VIABILITY, V20, pS1, DOI 10.1016/j.jtv.2011.07.002
   Wilkes R, 2009, J MECH BEHAV BIOMED, V2, P272, DOI 10.1016/j.jmbbm.2008.10.006
   Wilkes R, 2009, J BIOMECH ENG-T ASME, V131, DOI 10.1115/1.2947358
NR 29
TC 3
Z9 4
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUN 1
PY 2024
VL 13
IS 6
BP 291
EP 307
DI 10.1089/wound.2023.0096
EA FEB 2024
PG 17
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UE1N8
UT WOS:001176090600001
PM 38205649
OA hybrid
DA 2026-07-24
ER

PT J
AU Matsumoto, T
   Parekh, SG
AF Matsumoto, Takumi
   Parekh, Selene G.
TI Use of Negative Pressure Wound Therapy on Closed Surgical Incision After
   Total Ankle Arthroplasty
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE dressing; incisional negative pressure wound therapy; surgical
   complications; total ankle arthroplasty; wound healing problem
ID VACUUM-ASSISTED CLOSURE; FOLLOW-UP; HIP-ARTHROPLASTY; RISK-FACTORS;
   COMPLICATIONS; REPLACEMENT; MANAGEMENT; DRAINAGE; PROSTHESES; FRACTURES
AB Background: Wound healing problems of the anterior ankle incision are among the most common complications after total ankle arthroplasty, possibly resulting in exposure of the prostheses and infection. The aim of this study was to investigate the role of negative pressure wound therapy (NPWT) in decreasing the rate of wound healing problems after total ankle arthroplasty.
   Methods: This is a retrospective cohort study including consecutive patients who underwent total ankle arthroplasty by a single surgeon at a single institution between 2009 and 2013. The incisional negative pressure dressing was applied to all patients who underwent total ankle arthroplasty between 2012 and 2013 with a continuous application of -80 mm Hg negative pressure for 6 days postoperatively. The control group consisted of patients who underwent total ankle arthroplasty between 2009 and 2012 with a conventional nonadherent gauze dressing. Seventy-four patients were involved in this study: 37 in the control group and 37 in the incisional NPWT group.
   Results: All patients tolerated the incisional NPWT to completion without any dressing failures or skin problems. Both groups showed similar distributions in demographics and perioperative risk factors for wound healing. There were 9 (24%) wound healing problems in the control group and 1 (3%) in the incisional NPWT group. Incisional NPWT was found to reduce wound healing problems with an odds ratio of 0.10 (95% CI, 0.01-0.50; P = .004).
   Conclusions: Our study demonstrated that there was a decreased incidence of wound healing problems following total ankle arthroplasty with incisional NPWT dressings. This is the first study evaluating the efficacy of incisional NPWT as an adjunct treatment for wound healing after total ankle arthroplasty.
   Level of Evidence: Level III, retrospective comparative study.
C1 [Matsumoto, Takumi; Parekh, Selene G.] Duke Univ, Dept Orthopaed Surg, Med Ctr, Durham, NC USA.
   [Parekh, Selene G.] Duke Fuqua Sch Business, Durham, NC USA.
C3 Duke University; Duke University
RP Parekh, SG (通讯作者)，Duke Univ Hosp, North Carolina Orthopaed Clin, Dept Orthopaed, 3609 Southwest Durham Dr, Durham, NC 27709 USA.
EM selene.parekh@gmail.com
OI Parekh, Selene/0000-0002-1308-9038
CR Anderson T, 2003, J BONE JOINT SURG AM, V85A, P1321, DOI 10.2106/00004623-200307000-00019
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   Brigido SA, 2014, J FOOT ANKLE SURG, V53, P692, DOI 10.1053/j.jfas.2014.04.001
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   Zaidi R, 2013, BONE JOINT J, V95B, P1500, DOI 10.1302/0301-620X.95B11.31633
NR 40
TC 45
Z9 50
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD JUL
PY 2015
VL 36
IS 7
BP 787
EP 794
DI 10.1177/1071100715574934
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA CL9KA
UT WOS:000357295900007
PM 25736324
DA 2026-07-24
ER

PT J
AU Berg, LT
   Jaakkola, P
AF Berg, L. T.
   Jaakkola, P.
TI KUOPIO TREATMENT STRATEGY AFTER DEEP STERNAL WOUND INFECTION
SO SCANDINAVIAN JOURNAL OF SURGERY
LA English
DT Article
DE Deep sternal wound infection; mediastinitis; m. pectoralis major flap;
   m. latissimus dorsi flap; sternotomy; surgical flaps
ID VACUUM-ASSISTED CLOSURE; EMORY 20-YEAR EXPERIENCE; MUSCLE FLAPS;
   CARDIAC-SURGERY; MANAGEMENT; MEDIASTINITIS; THERAPY
AB Backgrounds and Aims: Infection of sternotomy wound is a rare potentially fatal complication because of the risk for deep sternal infection. Current treatment comprises antibiotics, debridement, negative pressure wound therapy and sometimes transposition of muscle or omental flaps to fill the anterior mediastinal dead space.
   Material and Methods: The management of 60 consecutive deep sternotomy wound infections is reviewed. The one stage treatment was mostly chosen. In 5 patients after debridement, negative pressure wound therapy was used before flap reconstruction. Fifty-seven patients were rewired and 3 patients had sternectomy. The choice of the flap was based mainly on anatomic location of a sternal wound defect and also on which grafts been used in cardiac operation.
   Results: The unilateral turnover split pectoralis major flap was the choice for 50 patients. In 8 patients latissimus dorsi flap was used. Rectus abdominis was used as a standalone flap in 4 patients and in combination with pectoralis major in one. All patients survived after deep sternal wound infection. In only 33 patients the recovery was totally uneventful. In the remaining 27 patients there were one or more complications. Not a single flap was lost completely, but due to partial flap necrosis, a redo reconstruction was needed in 3 patients. Negative pressure wound therapy was used after flap reconstruction in eight patients with incomplete post-flap healing to prepare for wound revision and split thickness skin graft.
   Conclusions: A structured approach including both cardiac and plastic surgery in case of deep sternal wound infection is recommended. A single stage surgery with the help of muscle flap reconstruction is our standard treatment. With our protocol, we have been able to keep the mortality low.
C1 [Berg, L. T.] Kuopio Univ Hosp, Dept Plast Surg, SF-70210 Kuopio, Finland.
   [Jaakkola, P.] Kuopio Univ Hosp, Dept Cardiac Surg, SF-70210 Kuopio, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Kuopio University Hospital
RP Berg, LT (通讯作者)，Univ Kuopio, Cent Hosp, Dept Surg, PostBox 1777, FI-70211 Kuopio, Finland.
EM leena.berg@kuh.fi
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NR 20
TC 11
Z9 12
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1457-4969
EI 1799-7267
J9 SCAND J SURG
JI Scand. J. Surg.
PY 2013
VL 102
IS 1
BP 3
EP 8
DI 10.1177/145749691310200102
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 129YX
UT WOS:000317881000002
PM 23628629
OA Bronze
DA 2026-07-24
ER

PT J
AU Wang, JHY
   Williams, B
   Wlodarczyk, JR
   Gupta, A
   Kim, D
   Cologne, KG
   Koller, SE
   Hsieh, CSE
   Duldulao, MP
   Shin, J
AF Wang, Johnny
   Williams, Brian
   Wlodarczyk, Jordan R.
   Gupta, Abhinav
   Kim, Debora
   Cologne, Kyle G.
   Koller, Sarah E.
   Hsieh, Christine
   Duldulao, Marjun P.
   Shin, Joongho
TI First Experience with the NPseal®: A Novel Mechanically Powered Negative
   Pressure Dressing Applied to Colorectal Surgery Wounds
SO SURGICAL INNOVATION
LA English
DT Article
DE negative pressure wound therapy; closed-incisional negative pressure
   wound therapy; surgical site infection; wound healing; colorectal
ID SURGICAL SITE INFECTIONS; CARE-ASSOCIATED INFECTIONS; VACUUM-ASSISTED
   CLOSURE; FINANCIAL IMPACT; THERAPY; COST; RISK; PREVENTION; MANAGEMENT;
   TRIAL
AB Background The use of prophylactic closed-incisional negative pressure wound therapy after colorectal procedures has been shown to reduce postoperative wound complications and surgical site infection. We present our experience with a novel, closed-incision, mechanically powered negative pressure (MP-NPD) dressing after colorectal procedures.Methods This was a prospective, single-center, single-arm observational study assessing patient reported and wound healing outcomes of colorectal surgical incisions dressed with a MP-NPD. Consecutive patients, 18 years and older, that met inclusion criteria were enrolled between May 2021 and December 2021.Results Thirty patients were included (13 male/17 female) with a mean age of 62.7 +/- 11.8 years and mean body mass index of 25.5 +/- 4.4 kg/m2. The mean incision length covered was 3.0 +/- 1.8 cm. The median number of manual pinches required to initially activate the dressing with negative pressure within -75 to -125 mmHg was 12 (range 7-20). Four dressings were changed (13.3%) after drainage was noted inside the pump; not including these, 88.5% (23/26) of dressings held pressure consistently without any re-pinching during the 72-h period since they were first applied in the operating room. 75.9% of patients reported the dressing was "very comfortable" and none reported the dressing restricted mobility. 79.3% of patients reported the dressing was "very easy" to use. There were no cases of major wound complication or surgical site infection within 30 days.Conclusion The use of MP-NPD appears to be feasible on primarily-closed colorectal incisions. Further randomized controlled study is warranted to ascertain its clinical efficacy.
C1 [Wang, Johnny; Williams, Brian; Wlodarczyk, Jordan R.; Gupta, Abhinav; Cologne, Kyle G.; Koller, Sarah E.; Hsieh, Christine; Duldulao, Marjun P.; Shin, Joongho] USC, Keck Hosp, Div Colorectal Surg, 1441 Eastlake Ave, Suite 7418, Los Angeles, CA 90033 USA.
   [Wang, Johnny; Williams, Brian; Wlodarczyk, Jordan R.; Gupta, Abhinav; Kim, Debora; Cologne, Kyle G.; Koller, Sarah E.; Hsieh, Christine; Duldulao, Marjun P.; Shin, Joongho] USC, Keck Sch Med, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California
   Keck Hospital; University of Southern California; University of Southern
   California Keck Hospital
RP Williams, B (通讯作者)，USC, Keck Hosp, Div Colorectal Surg, 1441 Eastlake Ave, Suite 7418, Los Angeles, CA 90033 USA.
EM Brian.Williams@med.usc.edu
OI Willia, Brian/0000-0003-3222-3818
CR Anderson DJ, 2014, INFECT CONT HOSP EP, V35, P605, DOI 10.1086/676022
   Bonds AM, 2013, DIS COLON RECTUM, V56, P1403, DOI 10.1097/DCR.0b013e3182a39959
   Cagney D, 2020, WORLD J SURG, V44, P1526, DOI 10.1007/s00268-019-05335-x
   Cantero R, 2016, ADV SKIN WOUND CARE, V29, P114, DOI 10.1097/01.ASW.0000480458.60005.34
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   Chadi SA, 2014, DIS COLON RECTUM, V57, P999, DOI 10.1097/DCR.0000000000000161
   Gantz O, 2019, AM SURGEON, V85, P142
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   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
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   Uchino M, 2016, DIGEST SURG, V33, P449, DOI 10.1159/000446550
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NR 31
TC 1
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1553-3506
EI 1553-3514
J9 SURG INNOV
JI Surg. Innov.
PD APR
PY 2025
VL 32
IS 2
BP 127
EP 140
DI 10.1177/15533506241307729
EA DEC 2024
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 0AM3B
UT WOS:001373253100001
PM 39653591
DA 2026-07-24
ER

PT J
AU Pauser, J
   Nordmeyer, M
   Biber, R
   Jantsch, J
   Kopschina, C
   Bail, HJ
   Brem, MH
AF Pauser, Johannes
   Nordmeyer, Matthias
   Biber, Roland
   Jantsch, Jonathan
   Kopschina, Carsten
   Bail, Hermann J.
   Brem, Matthias H.
TI Incisional negative pressure wound therapy after hemiarthroplasty for
   femoral neck fractures - reduction of wound complications
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Femoral neck fractures; iNPWT; Negative pressure wound therapy; Wound;
   Wound secretion
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS; MANAGEMENT; SURGERY; HIP;
   MORTALITY; TRAUMA; DEFECT; BONE
AB The aim of the study was to evaluate the use of incisional negative pressure wound therapy (iNPWT) in wound healing after femoral neck fracture (FNF) treated with hip hemiarthroplasty (HA) and its influence on postoperative seromas, wound secretion, as well as time and material consumption for dressing changes. The study is a prospective randomised evaluation of iNPWT in patients with large surgical wounds after FNF. Patients were randomised either to be treated by iNPWT (group A) or a standard wound dressing (group B). Follow-up included ultrasound measurements of seroma volumes on postoperative days 5 and 10, duration of wound secretion, and time and material spent for wound dressing changes. For comparison of the means, we used the t-test for independent samples, P > 0.05 was considered significant. There were 21 patients randomised in this study. Group A (11 patients, 81.6 +/- 5.2 years of age) developed a seroma of 0.257 +/- 0.75 cm(3) after 5 days and had a secretion of 0.9 +/- 1.0 days, and the total time for dressing changes was 14.8 +/- 3.9minutes, whereas group B (ten patients, 82.6 +/- 8.6 years of age) developed a seroma of 3.995 +/- 5.01 cm(3) after 5 days and had a secretion of 4.3 +/- 2.45 days, and the total time for dressing changes was 42.9 +/- 11.0 minutes. All mentioned differences were significant. iNPWT has been used on many different types of traumatic and non-traumatic wounds. This prospective, randomised study has demonstrated decreased development of postoperative seromas, reduction of total wound secretion days and reduction of needed time for dressing changes.
C1 [Pauser, Johannes; Nordmeyer, Matthias; Biber, Roland; Kopschina, Carsten; Bail, Hermann J.; Brem, Matthias H.] Univ Erlangen Nurnberg, Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer St 201, D-90471 Nurnberg, Germany.
   [Jantsch, Jonathan] Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Med Microbiol, Erlangen, Germany.
   [Jantsch, Jonathan] Univ Regensburg, Inst Med Microbiol & Hyg, Regensburg, Germany.
C3 Klinikum Nurnberg; University of Erlangen Nuremberg; University of
   Erlangen Nuremberg; University of Regensburg
RP Brem, MH (通讯作者)，Univ Erlangen Nurnberg, Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer St 201, D-90471 Nurnberg, Germany.
EM matthiasbrem@hotmail.de
RI Jantsch, Jonathan/KEE-9741-2024; Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
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NR 27
TC 48
Z9 52
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 663
EP 667
DI 10.1111/iwj.12344
PG 5
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600062
PM 25125244
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Karlakki, S
   Brem, M
   Giannini, S
   Khanduja, V
   Stannard, J
   Martin, R
AF Karlakki, S.
   Brem, M.
   Giannini, S.
   Khanduja, V.
   Stannard, J.
   Martin, R.
TI Negative pressure wound therapy for management of the surgical incision
   in orthopaedic surgery A REVIEW OF EVIDENCE AND MECHANISMS FOR AN
   EMERGING INDICATION
SO BONE & JOINT RESEARCH
LA English
DT Article
DE Incisional NPWT; Surgical site infection; Single-use NPWT; NPWT;
   Mechanism of action; Negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; EVIDENCE-BASED
   RECOMMENDATIONS; HIGH-RISK PATIENTS; SUBATMOSPHERIC PRESSURE;
   INTERNATIONAL CONSENSUS; SITE INFECTIONS; CARDIAC-SURGERY;
   LOWER-EXTREMITY; PREVENTION
AB Objectives
   The period of post-operative treatment before surgical wounds are completely closed remains a key window, during which one can apply new technologies that can minimise complications. One such technology is the use of negative pressure wound therapy to manage and accelerate healing of the closed incisional wound (incisional NPWT).
   Methods
   We undertook a literature review of this emerging indication to identify evidence within orthopaedic surgery and other surgical disciplines. Literature that supports our current understanding of the mechanisms of action was also reviewed in detail.
   Results
   A total of 33 publications were identified, including nine clinical study reports from orthopaedic surgery; four from cardiothoracic surgery and 12 from studies in abdominal, plastic and vascular disciplines. Most papers (26 of 33) had been published within the past three years. Thus far two randomised controlled trials - one in orthopaedic and one in cardiothoracic surgery - show evidence of reduced incidence of wound healing complications after between three and five days of post-operative NPWT of two- and four-fold, respectively. Investigations show that reduction in haematoma and seroma, accelerated wound healing and increased clearance of oedema are significant mechanisms of action.
   Conclusions
   There is a rapidly emerging literature on the effect of NPWT on the closed incision. Initiated and confirmed first with a randomised controlled trial in orthopaedic trauma surgery, studies in abdominal, plastic and vascular surgery with high rates of complications have been reported recently. The evidence from single-use NPWT devices is accumulating. There are no large randomised studies yet in reconstructive joint replacement.
C1 [Karlakki, S.] Robert Jones Agnes Hunt Orthopaed Hosp, Arthroplasty Dept, Oswestry SY10 7AG, Shrops, England.
   [Brem, M.] Univ Erlangen Nurnberg, Klinikum Nuernberg, Dept Orthopaed & Trauma Surg, D-90419 Nurnberg, Germany.
   [Giannini, S.] Ist Ortoped Rizzoli, I-40136 Bologna, Italy.
   [Khanduja, V.] Addenbrookes Hosp, Dept Trauma & Orthopaed, Cambridge CB2 0QQ, England.
   [Stannard, J.] Univ Missouri, Missouri Orthopaed Inst, Dept Orthopaed Surg, Columbia, MO 65212 USA.
   [Martin, R.] Smith & Nephew Ltd, Adv Wound Devices, Adv Wound Management Div, Kingston Upon Hull HU3 2BN, N Humberside, England.
C3 Keele University; Klinikum Nurnberg; University of Erlangen Nuremberg;
   IRCCS Istituto Ortopedico Rizzoli; Cambridge University Hospitals NHS
   Foundation Trust; Addenbrooke's Hospital; University of Cambridge;
   University of Missouri System; University of Missouri Columbia; Smith &
   Nephew
RP Martin, R (通讯作者)，Robert Jones Agnes Hunt Orthopaed Hosp, Oswestry, Shrops, England.
EM robin.martin@smith-nephew.com
RI Khanduja, Vikas/U-9318-2017
OI Khanduja, Vikas/0000-0001-9454-3978; Martin, Robin/0000-0002-9314-0437
FU Smith Nephew
FX The authors are members of an Expert Panel on incisional NPWT in
   orthopaedic surgery funded by Smith & Nephew. R. Martin is an employee
   of Smith & Nephew.
CR [Anonymous], DZF
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NR 67
TC 98
Z9 115
U1 0
U2 11
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD DEC
PY 2013
VL 2
IS 12
BP 276
EP 284
DI 10.1302/2046-3758.212.2000190
PG 9
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA AT2JP
UT WOS:000344761200004
PM 24352756
OA gold
DA 2026-07-24
ER

PT J
AU Gaudreau, G
   Costache, V
   Houde, C
   Cloutier, D
   Montalin, L
   Voisine, P
   Baillot, R
AF Gaudreau, Genevieve
   Costache, Victor
   Houde, Chanel
   Cloutier, Daniel
   Montalin, Livia
   Voisine, Pierre
   Baillot, Richard
TI Recurrent sternal infection following treatment with negative pressure
   wound therapy and titanium transverse plate fixation
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the Canadian-Society-of-Plastic-Surgeons
CY JUN 24-28, 2008
CL St Johns, CANADA
SP Canadian Soc Plast Surg
DE Deep sternal wound infection; Mediastinitis; Negative pressure wound
   therapy; Sternal reconstruction with titanium plates
ID VACUUM-ASSISTED CLOSURE; OPEN-HEART-SURGERY; POSTSTERNOTOMY
   MEDIASTINITIS; POSTOPERATIVE MEDIASTINITIS; MUSCLE FLAPS; EXPERIENCE;
   MANAGEMENT; RECONSTRUCTION; DEHISCENCE; UNIT
AB Objective: To provide a definition for recurrent sternal infection (RSI), analyse the risk factors and describe the management of this complication following treatment of deep sternal wound infection (DSWI) with horizontal titanium sternal osteosynthesis and coverage with pectoralis major myocutaneous flaps. Methods: Between 2002 and 2007, 10 665 patients were submitted to open-heart surgery (OHS) in our institution, of whom 149 (1.4%) developed a DSWI. Negative pressure wound therapy (NPWT) followed by sternal osteosynthesis with musculocutaneous coverage was used in 92 (61.7%) patients. A retrospective review was done using a prospectively maintained database to identify risk factors for recurrent infection in this group of patients. Results: Of the 92 patients who underwent sternal osteosynthesis, nine (9.8%) developed recurrent sternal infection requiring hardware removal. Univariate analysis showed that preoperative methicillin-resistant Staphylococcus aureus (MRSA) status (33.3% vs 6.1%; p = 0.03) and prolonged intubation time in ICU (44.4% vs 14.6%; p < 0.05) were significant risk factors. Two-thirds of these patients were also found to be infected with the same germ as the one responsible for their initial DSWI. No death was reported and sternal integrity was preserved in all patients despite plate removal. Conclusions: To lower the rate of RSI in patients treated with transverse sternal ostheosynthesis along with myocutaneous coverage for DSWI, surgeons must consider the MRSA preoperative status as a significant predictor of RSI and /or persistent infection. Chest-wall integrity in patients with RSI can be maintained after hardware removal, even after only a few weeks following initial plating. (C) 2009 European Association for Cardio-Thoracic SurgeryElsevier B.V. All rights reserved.
C1 [Costache, Victor] CHU Grenoble, Serv Chirurg Cardiaque, Dept Cardiac Surg, F-38043 Grenoble, France.
   [Gaudreau, Genevieve; Houde, Chanel; Cloutier, Daniel; Montalin, Livia; Voisine, Pierre; Baillot, Richard] Univ Laval, Dept Cardiac & Plast Surg, Quebec City, PQ, Canada.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Laval University
RP Costache, V (通讯作者)，CHU Grenoble, Serv Chirurg Cardiaque, Dept Cardiac Surg, BP 217, F-38043 Grenoble, France.
EM victorscostache@gmail.com
RI Costache, Victor/AFC-8705-2022
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NR 25
TC 30
Z9 35
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD APR
PY 2010
VL 37
IS 4
BP 888
EP 892
DI 10.1016/j.ejcts.2009.07.043
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 588DN
UT WOS:000277047700028
PM 19775906
DA 2026-07-24
ER

PT J
AU Poirier, A
   Albuisson, E
   Bihain, F
   Granel-Brocard, F
   Perez, M
AF Poirier, Antoine
   Albuisson, Eliane
   Bihain, Florence
   Granel-Brocard, Florence
   Perez, Manuela
TI Does Preventive Negative Pressure Wound Therapy (NPWT) reduce local
   complications following Lymph Node Dissection (LND) in the management of
   metastatic skin tumors?
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy (NPWT); Lymph node dissection (LND);
   Axillary-Inguinal-Melanoma-Squamous; Cell Carcinoma (SCC)-Merkel?s;
   neuroendocrine tumor; Lymphocele-Lymphedema
ID VACUUM-ASSISTED CLOSURE; CANCER; LYMPHADENECTOMY; INFECTION
AB Introduction: Axillary and inguinal lymph node dissection (LND) are performed in metastatic skin tumors with several local complications, such as lymphorrhea, lymphoceles, and lymphedema. The purpose of this study is to determine whether negative pressure wound therapy (NPWT) applied as a preventive measure could improve outcomes.Materials and Methods: A monocentric study included patients who underwent axillary or inguinal LND from May 2010 to March 2020, with a retrospective evaluation of prospectively collected data. Patients were divided into two groups: the conventional wound care (CWC) and the NPWT groups. Patients were systematically reviewed at D7, D30, and at 1 year postopera-tive, and data regarding lymphorrhea, lymphoceles, and lymphedema were collected.Results: A total of 109 axillary and inguinal LND were performed. NPWT was applied on 68 LND and CWC on 41 LND. The variables, diabetes, smoking, gender, associated treatments, and primary pathology (melanoma, squamous cell carcinoma, or Merkel tumors) were similar in both groups. Analyses have shown a significant difference in the rate of scar disunion during the first month between the two groups ( p = 0.045 between D1 and D7; p = 0.011 between D8 and D30), as well as the presence of lymphorrhea ( p = 0.000 between D1 and D7; p = 0.002 between D8 and D30). The rate of lymphoedema was significantly reduced in the NPWT group versus CWC (p =0.000 between D8 and D30; p =0.034 between D31 and 1 year).Conclusion: NPWT reduces local complications (scar disunion, lymphorrhea, and lymphedema) during the first year following LND in the management of node metastatic skin tumors.(c) 2022 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.
C1 [Poirier, Antoine; Bihain, Florence; Perez, Manuela] CHRU Nancy, Dept Chirurg Viscerale Metab & Cancerol CVMC, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [Albuisson, Eliane] CHRU Nancy, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [Granel-Brocard, Florence] CHRU Nancy, Serv Dermatol & Allergol, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
C3 CHU de Nancy; CHU de Nancy; CHU de Nancy
RP Poirier, A (通讯作者)，CHRU Nancy, Dept Chirurg Viscerale Metab & Cancerol CVMC, Hop Brabois, Rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
EM a.poirier@chru-nancy.fr
OI Bihain, Florence/0000-0002-4359-5134
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NR 23
TC 6
Z9 7
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD DEC
PY 2022
VL 75
IS 12
BP 4403
EP 4409
DI 10.1016/j.bjps.2022.08.054
EA NOV 2022
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 7N0OK
UT WOS:000907046600008
PM 36283927
DA 2026-07-24
ER

PT J
AU Fischer, S
   Wall, J
   Pomahac, B
   Riviello, R
   Halvorson, EG
AF Fischer, Sebastian
   Wall, Jennifer
   Pomahac, Bohdan
   Riviello, Robert
   Halvorson, Eric G.
TI Extra-large negative pressure wound therapy dressings for burns -
   Initial experience with technique, fluid management, and outcomes
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Fluid resuscitation; Burn wound; Vacuum
   assisted closure device
ID ACUTE-RENAL-FAILURE; THICKNESS SKIN-GRAFTS; AREA IF HEIGHT; INDUCED
   HYPOPROTEINEMIA; THERMAL-INJURY; RESUSCITATION; DEPTH; CARE; FORMULA;
   WEIGHT
AB Objective: The use of negative-pressure-wound-therapy (NPWT) is associated with improved outcomes in smaller burns. We report our experience using extra-large (XL) NPWT dressings to treat >= 15% total body surface area (TBSA) burned and describe our technique and early outcomes. We also provide NPWT exudate volume for predictive fluid resuscitation in these critically ill patients.
   Methods: We retrospectively reviewed patients treated with XL-NPWT from 2012 to 2014. Following excision/grafting, graft and donor sites were sealed with a layered NPWT dressing. We documented wound size, dressing size, NPWT outputs, graft take, wound infections, and length of stay (LOS). Mean NPWT exudate volume per %TBSA per day was calculated.
   Results: Twelve burn patients (mean TBSA burned 30%, range 15-60%) were treated with XL-NPWT (dressing TBSA burned and skin graft donor sites range 17-44%). Average graft take was 97%. No wound infections occurred. Two patients had burns >= 50% TBSA and their LOS was reduced compared to ABA averages. XL-NPWT outputs peaked at day 1 after grafting followed by a steady decline until dressings were removed. Average XL-NPWT dressing output during the first 5 days was 101 +/- 66 mL/%BSA covered per day. 2 patients developed acute kidney injury.
   Conclusion: The use of XL-NPWT to treat extensive burns is feasible with attention to application technique. NPWT dressings appear to improve graft take, and to decrease risk of infection, LOS, and pain and anxiety associated with wound care. Measured fluid losses can improve patient care in future applications of NPWT to large burn wounds. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.
C1 [Fischer, Sebastian; Pomahac, Bohdan; Halvorson, Eric G.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
   [Fischer, Sebastian] Heidelberg Univ, Dept Hand Plast & Reconstruct Surg, Res Grp Trauma Meets Burn, Burn Trauma Ctr,BG Trauma Ctr Ludwigshafen, Ludwig Guttmann Str 13, D-67071 Ludwigshafen, Germany.
   [Wall, Jennifer; Riviello, Robert] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Trauma Burns & Surg Crit Care, 75 Francis St, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Ruprecht Karls University
   Heidelberg; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Halvorson, EG (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM ehalvorson@partners.org
RI ; Pomahac, Bohdan/AAH-1792-2019; Fischer, Sebastian/AEX-5429-2022
OI , Sebastian/0000-0003-3445-1902; Pomahac, Bohdan/0000-0003-3703-8240; 
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NR 41
TC 22
Z9 25
U1 0
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD MAR
PY 2016
VL 42
IS 2
BP 457
EP 465
DI 10.1016/j.burns.2015.08.034
PG 9
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA DG6FW
UT WOS:000372179600034
PM 26774601
DA 2026-07-24
ER

PT J
AU Noble-Bell, G
   Forbes, A
AF Noble-Bell, Georgia
   Forbes, Angus
TI A systematic review of the effectiveness of negative pressure wound
   therapy in the management of diabetes foot ulcers
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Review
DE Diabetes mellitus; Foot ulcer; Negative pressure wound therapy;
   Systematic review; Vacuum-assisted closure
AB Foot ulcers are a common complication in patients with diabetes. Negative pressure wound therapy (NPWT) is a wound care therapy that is being increasingly used in the management of foot ulcers. This article presents a systematic review examining the effectiveness of this therapy. The review question is how effective is NPWT in achieving wound healing in diabetes foot ulcers? The primary outcome for this study was the number of patients achieving complete wound healing (secondary outcomes, other markers of wound healing, adverse events and patient satisfaction). A systematic literature review and tabulative synthesis of randomised controlled trials (RCTs). The review identified four RCTs of weak to moderate quality. Only one study examining NPWT in postamputation wound healing reported data on the primary outcome. These data show a 20% improvement in wound healing [odds ratios = 2.0%, confidence interval (CI) -1.0 to 4.0] and number needed to treat 6 (CI 4-64). No serious treatment-related complications were reported by any of the studies. One study suggested a reduction in the risk of secondary amputation (absolute risk reduction = 7.9%, CI 0.5-15.43). Studies also reported an increase in granulation and wound-healing rates in patients treated with NPWT therapy. No data on patient satisfaction or experience were reported. While all the studies included in the review indicated that the NPWT therapy is more effective than conventional dressings, the quality of the studies were weak and the nature of the inquiries in terms of outcome and patient selection divergent. There is a strong need for larger trials to assess NPWT therapy in diabetes care with different groups of patients and in relation to different clinical objectives and parameters.
C1 [Noble-Bell, Georgia; Forbes, Angus] Kings Coll London, Florence Nightingale Sch Nursing & Midwifery, London SE1 8WA, England.
C3 University of London; King's College London
RP Forbes, A (通讯作者)，Kings Coll London, Florence Nightingale Sch Nursing & Midwifery, James Clerk Maxwell Bldg,57 Waterloo Rd, London SE1 8WA, England.
EM angus.forbes@kcl.ac.uk
OI Forbes, Angus/0000-0003-3331-755X
FU Mel Doxford (Diabetes Foot Practitioner)
FX The authors would like to acknowledge the support of Mel Doxford
   (Diabetes Foot Practitioner) and Dr Mike Edmonds (Consultant
   Diabetologist) who provided clinical expertise in conducting and writing
   the review.
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NR 31
TC 39
Z9 46
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAY
PY 2008
VL 5
IS 2
BP 233
EP 242
DI 10.1111/j.1742-481X.2008.00430.x
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16AW
UT WOS:000207843500012
PM 18494629
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Biermann, N
   Wallner, S
   Martini, T
   Spoerl, S
   Prantl, L
   Taeger, CD
AF Biermann, Niklas
   Wallner, Stefan
   Martini, Teresa
   Spoerl, Steffen
   Prantl, Lukas
   Taeger, Christian D. D.
TI Negative Pressure Wound Therapy with Instillation: Analysis of the
   Rinsing Fluid as a Monitoring Tool and Approach to the Inflammatory
   Process: A Pilot Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE negative pressure wound therapy with instillation; inflammation; wound
   healing
ID VACUUM-ASSISTED CLOSURE; CLEARANCE
AB Background: Negative pressure wound therapy with instillation (NPWTi) is an established wound conditioning tool. Previous investigations discovered that the rinsing fluid is a suitable monitoring tool containing various cells and cytokines. Methods: The aim of this pilot study was to analyze rinsing fluid samples from patients treated with NPWTi and link them to the clinical course, including microbiological contamination. In 31 consecutive patients with acute and chronic wounds, laboratory analysis was performed to evaluate IL-6, IL-8, bFGF, Tnf-a, and VEGF. Results: IL-6 showed a significant increase to 1540 pg/mL on day two and 860 pg/mL on day four (p = 0.01 and p = 0.04, resp.). IL-8 steadily increased from a median of 2370 pg/mL to a maximum of 19,400 pg/mL on day three (p = 0.01). The median bFGF showed a steady decline from 22 pg/mL to 10 pg/m (p = 0.35) on day three. The median Tnf-a increased from 11 pg/mL to 44 pg/mL (p = 001). The median VEGF values fluctuated but showed an overall increase from 35 pg/mL to 250 pg/mL (p = 0.07). Regarding IL-8, diabetic and non-diabetic patients both showed a gradual increase with non-significant higher median values for the diabetics. The subgroup analysis of IL-6 showed increasing and higher values in cases with bacterial superinfections (p = 0.07). Conclusion: We were able to use an established wound conditioning tool to gather important information about the inflammatory response during NPWTi treatment. Cytokine and cell courses were mostly consistent with the literature, especially in diabetic patients, and should be further investigated.
C1 [Biermann, Niklas; Martini, Teresa; Prantl, Lukas; Taeger, Christian D. D.] Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
   [Wallner, Stefan] Univ Hosp Regensburg, Dept Clin Chem, D-93053 Regensburg, Germany.
   [Spoerl, Steffen] Univ Hosp Regensburg, Clin & Polyclin Oral & Maxillofacial Surg, D-93053 Regensburg, Germany.
C3 University of Regensburg; University of Regensburg; University of
   Regensburg
RP Biermann, N (通讯作者)，Univ Hosp Regensburg, Dept Plast Hand & Reconstruct Surg, D-93053 Regensburg, Germany.
EM niklas.biermann@ukr.de
RI prantl, Lukas/AAM-1848-2021
OI prantl, Lukas/0000-0003-2454-2499
FU Manfred Roth Stiftung [n.a] Funding Source: Medline
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NR 29
TC 2
Z9 3
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2023
VL 12
IS 2
AR 711
DI 10.3390/jcm12020711
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7Z3XS
UT WOS:000915496500001
PM 36675638
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Davis, KE
   Bills, J
   Noble, D
   Crisologo, PA
   Lavery, LA
AF Davis, Kathryn E.
   Bills, Jessica
   Noble, Debby
   Crisologo, Peter A.
   Lavery, Lawrence A.
TI Ultraviolet-A Light and Negative-Pressure Wound Therapy to Accelerate
   Wound Healing and Reduce Bacterial Proliferation
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; CONTROLLED-TRIAL;
   MANAGEMENT; IRRADIATION; MULTICENTER; PREVALENCE; AMPUTATION; DISEASE;
   KIDNEY
AB Background: Ultraviolet (UV)-A therapy is a simple, inexpensive, and effective modality for wound healing, with tremendous potential to improve healing and reduce clinical infections in a number of clinical settings. To date, application of UV-A relies on bulky and hard -to-dose lamps that provide inconsistent therapy, thus making it difficult to apply therapy that is appropriate for the patient.Methods: This study was designed to test the effectiveness of a novel wound therapy de -vice that combines UV-A with traditional negative-pressure wound therapy (NPWT) to pro -mote wound healing. Furthermore, we tested the ability of fiberoptic UV-A delivery to inhibit bacterial proliferation. Finally, we assayed the level of DNA damage that results from UV-A as compared to established UV-C therapies. Wound healing studies were performed in a porcine model using an articulated therapy arm that allows for continued therapy administra-tion over an extended time course. Negative-pressure wound therapy was administered alone or with UV-A fiberoptic therapy for 2 weeks. Dressings were changed twice a week, at which time wound area was assessed.Results: Data demonstrate that UV-A with NPWT treatment of wounds results in greater healing than NPWT alone. Using the same therapy device, we demonstrate that exposure of Staphylococcus aureus and Pseudomonas aeruginosa to fiberoptic UV-A results in decreased colony area and number of both bacterial strains. Finally, we show that UV-A induces minimal DNA damage in human fibroblasts and no more DNA damage in wound tis-sue as compare to intact skin.Conclusions: These data demonstrate that UV-A can decrease bacterial proliferation and promote wound healing when coupled with NPWT. (J Am Podiatr Med Assoc 113(1), 2023)
C1 [Davis, Kathryn E.; Bills, Jessica; Noble, Debby; Crisologo, Peter A.; Lavery, Lawrence A.] Univ Texas Southwestern Med Ctr, Dept Plast Surg, Dallas, TX USA.
   [Crisologo, Peter A.] Univ Cincinnati Med Ctr, Dept Surg, Cincinnati, OH USA.
   [Davis, Kathryn E.] Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd F4-310A, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University System of Ohio; University of Cincinnati; University
   of Texas System; University of Texas Southwestern Medical Center
RP Davis, KE (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Plast Surg, 5323 Harry Hines Blvd F4-310A, Dallas, TX 75390 USA.
EM kathryn.davis@utsouthwestern.edu
RI Crisologo, Peter/JZE-5379-2024
OI Crisologo, Peter/0000-0002-5367-9235
FU Thermotek, Inc.; Cardinal Health; Avazzia; EO2 Concepts; MedImmune;
   Pluristem Therapeutics Inc; Osiris Therapeutics; KCI; Pluristem
   Therapeutics, Inc
FX This study was supported by an educational grant from Thermotek, Inc.
   Kathryn E. Davis, PhD, has research funding from Cardinal Health,
   Avazzia, EO2 Concepts, MedImmune, Pluristem Therapeutics Inc, Osiris
   Therapeutics; and consulting agreements with EO2 Concepts, Cardinal
   Health, Bayer, Medline Industries, Boehringer Ingelheim, and Medimmune.
   Jessica Bills, BS, and Debby Noble, BS, have no relevant conflicts of
   interest. Lawrence A. Lavery, DPM, MPH, has research funding from
   Cardinal Health, KCI, EO2 Concepts, Osiris Therapeutics, Avazzia, and
   Pluristem Therapeutics, Inc; and consulting agreements with EO2
   Concepts, Cardinal Health, Bayer, Medline Industries, Boehringer
   Ingelheim, and Medimmune.
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NR 36
TC 0
Z9 0
U1 0
U2 8
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD JAN-FEB
PY 2023
VL 113
IS 1
AR 251
DI 10.7547/20-251
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA Z4TW1
UT WOS:001112027400005
PM 34233359
DA 2026-07-24
ER

PT J
AU McCaughan, D
   Sheard, L
   Cullum, N
   Dumville, J
   Chetter, I
AF McCaughan, Dorothy
   Sheard, Laura
   Cullum, Nicky
   Dumville, Jo
   Chetter, Ian
TI Nurses' and surgeons' views and experiences of surgical wounds healing
   by secondary intention: A qualitative study
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE healing by secondary intention; nurses; open surgical wounds;
   qualitative; surgeons
ID VACUUM-ASSISTED CLOSURE; THERAPY; PREVALENCE; CARE
AB Aims and Objectives To explore surgeons' and nurses' perspectives of managing surgical wounds healing by secondary intention.
   Background Every year, more than 10 million surgical operations are performed in the NHS in the UK. Most surgical wounds heal by primary intention, where the edges of the wound are brought together with staples, sutures, adhesive glue or clips. Sometimes wounds are deliberately left open to heal, from the base up, known as "healing by secondary intention." These wounds are often slow to heal, prone to infection and complex to manage.
   Design A qualitative, descriptive approach, using semi-structured interviews.
   Methods Interviews with five (general, vascular and plastic) surgeons and 7 nurses (3 tissue viability nurses, 2 district and 1 community nurse, and 1 hospital nurse) working in hospital and community care settings in two locations in the north of England. Data analysis followed the recommended sequential steps of "Framework" approach. Consolidated criteria for reporting qualitative research guided the study report.
   Results Participants reported that the main types of wounds healing by secondary intention that they manage are extensive abdominal cavity wounds; open wounds relating to treatment for pilonidal sinus; large open wounds on the feet of patients with diabetes; and axilla and groin wounds, associated with removal of lymph nodes for cancer. Infection and prolonged time to healing were the main challenges. Negative pressure wound therapy was the most favoured treatment option.
   Conclusions Negative pressure wound therapy was advocated by professionals despite a lack of research evidence indicating clinical or cost-effectiveness. Our findings underscore the need for rigorous evaluation of negative pressure wound therapy, and other wound care treatments, through studies that include economic evaluation.
   Relevance for clinical practice Clinical decision-making in wound care could be optimised through further robust studies to inform practitioners about the cost-effectiveness of available treatments.
C1 [McCaughan, Dorothy] Univ York, Dept Hlth Sci, Seebohm Rowntree Bldg, York YO10 5DD, N Yorkshire, England.
   [Sheard, Laura] Bradford Inst Hlth Res, Bradford, W Yorkshire, England.
   [Cullum, Nicky] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Nursing, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Dumville, Jo] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Appl Hlth Res, Div Nursing Midwifery & Social Work,Sch Hlth Sci, Manchester, Lancs, England.
   [Cullum, Nicky] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Res & Innovat Div, Nursing, Manchester, Lancs, England.
   [Chetter, Ian] Univ Hull, Hull York Med Sch, Acad Vasc Surg Unit, Surg, Kingston Upon Hull, N Humberside, England.
   [Chetter, Ian] East Yorkshire NHS Trust, Surg, Kingston Upon Hull, N Humberside, England.
C3 University of York - UK; University of Manchester; University of
   Manchester; University of Manchester; Manchester University NHS
   Foundation Trust; University of York - UK; University of Hull
RP McCaughan, D (通讯作者)，Univ York, Dept Hlth Sci, Seebohm Rowntree Bldg, York YO10 5DD, N Yorkshire, England.
EM dorothy.mccaughan@york.ac.uk
RI ; Dumville, Jo/O-7867-2014; Cullum, Nicky/F-2438-2011
OI chetter, ian/0000-0002-2566-6859; Dumville, Jo/0000-0002-6546-3685;
   Cullum, Nicky/0000-0003-2631-123X; McCaughan,
   Dorothy/0000-0001-5388-2455
FU National Institute for Health Research (NIHR, UK) Programme Grants for
   Applied Research; National Institute for Health Research
   [RP-PG-0609-10171] Funding Source: researchfish; National Institutes of
   Health Research (NIHR) [RP-PG-0609-10171] Funding Source: National
   Institutes of Health Research (NIHR)
FX This study was funded by the National Institute for Health Research
   (NIHR, UK) Programme Grants for Applied Research: Application
   RP-PG-0609-10171-surgical wounds healing by secondary intention:
   characterising and quantifying the problem and identifying effective
   treatments.
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   [Anonymous], TEACHING WOUND MANAG
   [Anonymous], SURG WOUNDS HEALING
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NR 44
TC 9
Z9 12
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD JUL
PY 2020
VL 29
IS 13-14
BP 2557
EP 2571
DI 10.1111/jocn.15279
EA APR 2020
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA LZ4YB
UT WOS:000527779900001
PM 32279371
OA Green Submitted, Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Large, TM
   Douglas, G
   Erickson, G
   Grayson, JK
AF Large, Thomas M.
   Douglas, Geoffrey
   Erickson, Gregory
   Grayson, J. Kevin
TI Effect of Negative Pressure Wound Therapy on the Elution of Antibiotics
   From Polymethylmethacrylate Beads in a Porcine Simulated Open Femur
   Fracture Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy; bone cement; anti-bacterial agents;
   tobramycin; vancomycin
ID VACUUM-ASSISTED CLOSURE; ACRYLIC BONE-CEMENT; OPEN CELL FOAM;
   SOFT-TISSUE INJURIES; SPACERS IN-VIVO; 2-STAGE REVISION; HIP SPACERS;
   VANCOMYCIN; GENTAMICIN; TOBRAMYCIN
AB Objectives: To determine whether negative pressure wound therapy (NPWT) affects antibiotic elution in simulated femur fractures treated with antibiotic impregnated polymethylmethacrylate (PMMA) beads and whether fascial closure between beads and sponge affects the outcome.
   Methods: PMMA beads containing vancomycin and tobramycin were placed adjacent to bilateral corticotomies created in 20 anesthetized pigs. In 1 leg, NPWT was applied with the sponge either in direct contact with the beads or superficial to reapproximated fascia lata. The contralateral wound was conventionally closed. Vancomycin and tobramycin concentrations in wound drainage were measured every 12 hours for 72 hours, and tobramycin levels were measured in periosteal tissue obtained at 72 hours.
   Results: Drainage vancomycin and tobramycin concentrations were highest at 12 hours and fell rapidly by 24 hours but remained steady thereafter. At each 12-hour interval, there were no significant differences in the vancomycin and tobramycin concentrations between NPWT and control wound drainage, although whether the fascia was closed or left open had an influence on vancomycin levels. The total vancomycin and tobramycin eluted into the drains was significantly less in the NPWT group with open fascia. The antibiotic levels measured in wound drainage remained above the minimum inhibitory concentration for common wound organisms throughout the study period. Neither NPWT nor fascial closure had a significant effect on tobramycin periosteal tissue concentrations.
   Conclusions: Concurrent application of NPWT with antibiotic impregnated PMMA beads to simulated open femur fractures in pigs did not decrease local antibiotic concentrations but did decrease the total amount of eluted vancomycin and tobramycin locally available when the fascia was left open.
C1 [Large, Thomas M.; Erickson, Gregory] David Grant USAF Med Ctr, Dept Orthopaed Surg, Bodin Circle Travis AFB, CA 94535 USA.
   [Douglas, Geoffrey; Grayson, J. Kevin] David Grant USAF Med Ctr, Clin Invest Facil, Bodin Circle Travis AFB, CA 94535 USA.
RP Large, TM (通讯作者)，David Grant USAF Med Ctr, Dept Orthopaed Surg, 101 Bodin Circle Travis AFB, Bodin Circle Travis AFB, CA 94535 USA.
EM tom_large@hotmail.com
OI Large, Thomas/0000-0002-7087-0031
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NR 39
TC 9
Z9 14
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2012
VL 26
IS 9
BP 506
EP 511
DI 10.1097/BOT.0b013e31825354ce
PG 6
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 999YQ
UT WOS:000308352200015
PM 22549033
DA 2026-07-24
ER

PT J
AU Yogun, Y
   Bezirgan, U
   Ertan, MB
   Savran, MD
   Kindan, P
   Kalem, M
   Armangil, M
AF Yogun, Yener
   Bezirgan, Ugur
   Ertan, Mehmet Batu
   Savran, Merve Dursun
   Kindan, Peri
   Kalem, Mahmut
   Armangil, Mehmet
TI Comparison of Negative-Pressure Wound Therapy and Gradual Wound
   Approximation Treatments for Infected Fasciotomy Wounds
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE crush injury; earthquake; gradual wound approximation; infected
   fasciotomy wounds; negative-pressure wound therapy
ID ACUTE COMPARTMENT SYNDROME; VACUUM-ASSISTED CLOSURE
AB Negative-pressure wound therapy (NPWT) and gradual wound approximation (GWA) are effective and reliable methods of treating fasciotomy wounds. However, the effectiveness of these 2 methods in treating infected wounds remains unclear. The aim of our study was to compare these 2 delayed primary closure methods of treating infected fasciotomy wounds on the limbs. Patients who underwent fasciotomy surgery on the extremities after sustaining crushing injuries in the 2023 Kahramanmara & scedil;-centered earthquakes and who were referred owing to infected open wounds during follow-up were included in the study. Patients who completed the wound closure process at our clinic were divided into 2 groups: the NPWT and GWA groups. Using retrospectively collected data, the groups were compared in terms of demographic characteristics, time until wound closure, number of surgeries, skin graft requirements, and complications. Laboratory parameters were also examined. Thirteen patients, (with 21 wounds) who underwent NPWT and 14 (with 22 wounds) who underwent GWA, were examined. The average age of the NPWT group was 32.85 +/- 18.37 years, whereas that of the GWA group was 25.21 +/- 16.31 years. The number of surgeries in the NPWT and GWA groups were 5.38 +/- 2.11 and 4.23 +/- 1.27, respectively, and the difference was statistically significant (P = .040). The average wound closure times of the NPWT and GWA groups (P = .0210) (11.00 +/- 4.86 days and 8.27 +/- 2.41 days, respectively) also differed significantly. Skin grafting was performed in 5 patients in the NPWT group and 2 in the GWA group. There were no significant differences between the 2 groups in terms of skin graft requirements or complication rates. NPWT and GWA are effective and reliable methods of closing infected fasciotomy wounds. Closure of these wounds can be achieved in a shorter time and with fewer surgeries using GWA than using NPWT.
C1 [Yogun, Yener] Van Training & Res Hosp, Hand Surg Unit, TR-65300 Van, Turkiye.
   [Bezirgan, Ugur; Armangil, Mehmet] Ankara Univ, Fac Med, Orthoped & Traumatol Dept, Hand Surg Unit, Ankara, Turkiye.
   [Ertan, Mehmet Batu] Medicana Int Ankara Hosp, Orthoped & Traumatol Dept, Ankara, Turkiye.
   [Savran, Merve Dursun; Kindan, Peri; Kalem, Mahmut] Ankara Univ, Fac Med, Orthoped & Traumatol Dept, Ankara, Turkiye.
C3 Van Training & Research Hospital; Ankara University; Medicana Hospital;
   Ankara University
RP Yogun, Y (通讯作者)，Van Training & Res Hosp, Hand Surg Unit, TR-65300 Van, Turkiye.
EM yogunyener@gmail.com
RI Ertan, Mehmet Batu/AAN-4844-2021; Yoğun, Yener/ABD-8622-2021; Kindan
   Baltaci, Peri/LBA-9282-2024; armangil, mehmet/AAH-6136-2020; dursun
   savran, merve/HOC-0256-2023; kalem, mahmut/HSD-0104-2023
OI Ertan, Mehmet Batu/0000-0001-6757-9967; Yoğun,
   Yener/0000-0002-3070-5509; Kindan Baltaci, Peri/0009-0005-1302-9085;
   dursun savran, merve/0000-0002-9473-7948; 
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NR 26
TC 2
Z9 2
U1 1
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD MAR
PY 2025
VL 24
IS 1
SI SI
BP 92
EP 101
DI 10.1177/15347346241266652
EA JUL 2024
PG 10
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA Y0X7J
UT WOS:001275121200001
PM 39033381
DA 2026-07-24
ER

PT J
AU Serena, TE
   Jalodi, O
   Serena, L
   Patel, K
   Mynti, M
AF Serena, Thomas E.
   Jalodi, Omar
   Serena, Laura
   Patel, Keyur
   Mynti, Matthew
TI Evaluation of the combination of a biofilm-disrupting agent and negative
   pressure wound therapy: a case series
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE biofilm; dressing; negative pressure wound therapy; pressure injuries;
   pressure ulcers; wound; wound care; wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; CARE
AB Objective: Approximately three million people in the US have hardto-heal pressure ulcers (PUs), including 10% of hospitalised patients. Healing depends on ulcer stage and patient comorbidities. Despite advances in nutrition and wound care, PUs can take months or years to reach complete closure. To date, clinical studies have focused on single modality therapy. However, there is no one therapy that can address all of the deficits in these complex, hard-to-heal wounds. A commonly used treatment for PUs, negative pressure wound therapy (NPWT), has demonstrated improved healing in Stage 3 and 4 PUs. NPWT entails applying suction to a porous sponge fitted into the wound cavity and sealed with an occlusive dressing. Negative pressure facilitates wound healing by removing wound fluid containing harmful proteases, stimulating the formation of granulation tissue and promoting wound contracture. However, it does not affect biofilm formation. We hypothesised that adding an antibiofilm agent might increase the effectiveness of NPWT in recalcitrant PUs.
   Method: A prospective case series was conducted in outpatient wound care centres and a skilled nursing facility to examine the combination of a biofilm disrupting antimicrobial agent (Blast-X, Next Science, US) in combination with NPWT (VAC, 3M, US) in healing and reducing bacterial burden in treatment-resistant pressure ulcers. Patients consented to application of the antibiofilm agent and NPWT three times per week for four weeks. The wounds were measured, imaged for bacteria and tested for host and bacterial protease activity weekly.
   Results: Of the 10 patients, four dropped out of the study before the end of the four weeks. Of the remaining six, four patients experienced a reduction in wound surface area and volume, reduced protease activity and lower bacterial levels.
   Conclusion: The results of this study showed that multimodal therapy, including NPWT and biofilm disruption, may restart the healing of stagnant treatment-resistant PUs.
C1 [Serena, Thomas E.; Jalodi, Omar; Serena, Laura] SerenaGrp Res Fdn, Cambridge, MA 02140 USA.
   [Patel, Keyur] D&P Med Grp, Pittsburgh, PA USA.
   [Mynti, Matthew] Next Sci Inc, Chatswood, NSW, Australia.
RP Serena, TE (通讯作者)，SerenaGrp Res Fdn, Cambridge, MA 02140 USA.
EM serena@serenagroups.com
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NR 24
TC 12
Z9 13
U1 2
U2 10
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2021
VL 30
IS 1
BP 9
EP 14
DI 10.12968/jowc.2021.30.1.9
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PW8TW
UT WOS:000610941500004
PM 33439086
DA 2026-07-24
ER

PT J
AU [Anonymous]
AF [Anonymous]
TI The Role of Negative Pressure Wound Therapy in the Spectrum of Wound
   Healing
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy; moist wound healing; traumatic and
   surgical wounds; pressure ulcers; diabetic foot ulcers; venous ulcers
   and arterial ulcers
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; PARTIAL-THICKNESS BURNS; CHRONIC LEG ULCERS;
   SUBATMOSPHERIC PRESSURE; OCCLUSIVE DRESSINGS; ALGINATE DRESSINGS;
   SUPERFICIAL WOUNDS; IONIC SILVER
AB Wound care clinicians have a wide array of available treatment options to manage and help heal acute and chronic complex wounds that require a systematized and comprehensive approach to address the complexity of wound care and to optimize patient outcomes. The treatment of wounds represents a major cost to society. Public policies increasingly focus on quality of care, patient outcomes, and lowering costs. Wound care clinicians are not immune to these pressures. Wound care clinicians must ensure that their assessments, treatment pathways, and product selections are both clinically and economically sound.
   Negative pressure wound therapy (NPWT) has been demonstrated to be an efficacious option to promote healing in a variety of acute and chronic complex wounds. Previous guidelines on the use of NPWT have focused on application but have not provided recommendations on when it is most appropriate to use NPWT; there are few criteria for 1) when to initiate NPWT based on various wound types, 2) pre-application management to optimize treatment outcomes, 3) identification of appropriate candidates for NPWT, 4) benchmark indicators for treatment response, and 5) recommendations on when to transition between NPWT and moist wound healing (MWH) or another treatment modality.
   In September 2009, an international panel of wound care experts from multiple disciplines convened to develop a document to guide clinicians in making decisions about the appropriate use of NPWT within the spectrum of wound healing. Where empirical research was lacking, clinical experiences and patient factors were considered to ensure the clinical utility of the document. The goal of these guidelines is to encourage responsible wound management across the healthcare continuum and spectrum of wound pathologies to achieve positive, cost-effective patient outcomes.
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NR 74
TC 0
Z9 0
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD MAY
PY 2010
SU S
BP 3
EP 18
PG 16
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 603JM
UT WOS:000278204900001
DA 2026-07-24
ER

PT J
AU Ling, SNW
   Kuan, NLK
   Abraham, M
   Jack, PW
   Leong, KLB
AF Ling, Stacy Ng Wei
   Kuan, Nicole Lee Kim
   Abraham, Mini
   Jack, Pan Woei
   Leong, Kevin Lim Boon
TI Negative pressure wound therapy in paediatric scoliosis surgery: a pilot
   study
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE 3M Prevena; fusion; negative pressure wound therapy; paediatric
   patients; prophylaxis; scoliosis; surgical site infection; negative
   wound; wound care; wound dressing; wound healing
ID VACUUM-ASSISTED CLOSURE; ADOLESCENT IDIOPATHIC SCOLIOSIS; INSTRUMENTED
   SPINAL-FUSION; INFECTION; CHILDREN; DEHISCENCE; MANAGEMENT; INCISIONS
AB Objective: To evaluate the use of negative pressure wound therapy (NPWT) in healing closed spinal incisions following scoliosis deformity surgery in a paediatric cohort. Method: A retrospective review of patients <21 years of age who underwent posterior spinal instrumentation and fusion for severe scoliosis between 2019-2022. Patients were divided into two groups. The first comprised patients with idiopathic scoliosis (IS) treated with 3M Prevena (SolventumUS) application (Group P-IS). They were compared against a matched group who received standard dressings (Group S-IS). The second group comprised patients with non-idiopathic scoliosis (NIS) treated with 3M Prevena application (Group P-NIS), and who were compared against a matched group who received standard dressings (Group S-NIS). Results: The first group had a total of 31 patients (Group P-IS) who were compared to 35 patients (Group S-IS). Seroma formation, wound dehiscence, surgical site infections (SSIs), duration of hospitalisation and the number of visits until complete wound healing was higher in Group S-IS, although statistical significance (p<0.05) was not reached. In the second group, a total of 17 patients (Group P-NIS) were compared against 13 patients (Group S-NIS). Seroma formation, duration of hospitalisation and number of visits until complete wound healing was higher in Group S-NIS. Conclusion: In this study, NPWT following primary closure in scoliosis surgery resulted in reduced seroma formation, wound dehiscence and SSIs in patients with IS, and reduced seroma formation in NIS patients. NPWT was beneficial in augmenting wound healing following paediatric spinal surgery and should be further examined in larger-scale prospective studies.
C1 [Ling, Stacy Ng Wei; Abraham, Mini; Jack, Pan Woei; Leong, Kevin Lim Boon] KK Womens & Childrens Hosp, Dept Orthopaed Surg, 100 Bukit Timah Rd, Singapore, Singapore.
   [Kuan, Nicole Lee Kim] KK Womens & Childrens Hosp, Div Surg, 100 Bukit Timah Rd, Singapore, Singapore.
C3 KK Women's & Children's Hospital; KK Women's & Children's Hospital
RP Ling, SNW (通讯作者)，KK Womens & Childrens Hosp, Dept Orthopaed Surg, 100 Bukit Timah Rd, Singapore, Singapore.
EM stace.ng@gmail.com
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NR 28
TC 0
Z9 0
U1 0
U2 0
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2052-2916
J9 J WOUND CARE
JI J. Wound Care
PD JAN
PY 2026
VL 35
IS 1
BP 68
EP 74
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CG6PI
UT WOS:001665330800001
PM 41528794
DA 2026-07-24
ER

PT J
AU Stanciu, CT
   Vermesan, D
   Pop, DL
   Hogea, B
   Vlad, SV
AF Stanciu, Cristina-Teodora
   Vermesan, Dinu
   Pop, Daniel Laurentiu
   Hogea, Bogdan
   Vlad, Silviu Valentin
TI Functional and Clinical Outcomes in Acute Wound Management: Measuring
   the Impact of Negative Pressure Wound Therapy and Specialized Physical
   Therapy
SO LIFE-BASEL
LA English
DT Article
DE negative pressure wound therapy; rehabilitation techniques;
   proprioceptive neuromuscular facilitation; wound healing; joint mobility
ID VACUUM-ASSISTED CLOSURE
AB Background and Objectives: Optimizing functional recovery alongside wound healing remains a challenge in acute wound management. Negative Pressure Wound Therapy (NPWT) is widely used to promote tissue regeneration and reduce edema, yet its impact on functional outcomes and quality of life is less explored. This study evaluates the effects of NPWT alone versus NPWT combined with physiotherapy, focusing on functional recovery and patient-reported outcomes. Materials and Methods: This prospective study included patients with acute wounds at the Timisoara County Emergency Clinical Hospital, treated between 2020 and 2024. Participants were divided into two groups: Group 1, receiving NPWT exclusively, and Group 2, undergoing NPWT combined with physiotherapy (Proprioceptive Neuro-muscular Facilitation, Kabat diagonals, manual lymphatic drainage, and proprioceptive exercises). Assessments included joint mobility (goniometry), edema (circumferential measurements), muscle strength (Manual Muscle Testing), and patient-reported outcomes using WHOQOL-BREF, SF-36, and HADS questionnaires. Results: Results demonstrated that, at 10 days, patients in the specialized physiotherapy group had significantly greater ankle dorsiflexion (18.10 +/- 1.63 degrees) compared to the classical group (10.05 +/- 1.76 degrees; p < 0.001). Knee flexion in the specialized group was 134.58 +/- 5.15 degrees versus 115.57 +/- 5.32 degrees in the classical group (p < 0.001). Edema circumference and depth were reduced in both groups, with minor but notable improvements in the specialized group at later follow-ups (p < 0.05). Self-reported quality of life (SF-36, WHOQOL-BREF) and mental health (HADS) scores were slightly better at 10 days in the specialized group, although differences diminished by 6 months. Conclusions: Combining NPWT with specialized physiotherapy techniques enhances functional recovery and quality of life in acute wound patients. These findings support the integration of multi-disciplinary rehabilitation to optimize patient outcomes.
C1 [Stanciu, Cristina-Teodora] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch, Timisoara 300041, Romania.
   [Vermesan, Dinu; Pop, Daniel Laurentiu; Hogea, Bogdan] Victor Babes Univ Med & Pharm Timisoara, Dept Orthoped Traumatol Urol & Med Imaging 16, Timisoara 300041, Romania.
   [Vlad, Silviu Valentin] Univ Oradea, Fac Med, Dept Surg, Oradea 410073, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; University of Oradea
RP Hogea, B (通讯作者)，Victor Babes Univ Med & Pharm Timisoara, Dept Orthoped Traumatol Urol & Med Imaging 16, Timisoara 300041, Romania.
EM cristina.stanciu@umft.ro; dinu@vermesan.ro;
   daniellaurentiupop@yahoo.com; hogea.bogdan@umft.ro;
   siviu.vlad@didactic.uoradea.ro
RI ; Vlad, Silviu/JWP-8448-2024
OI Hogea, Bogdan/0000-0003-4924-7832; 
FU Victor Babes University of Medicine and Pharmacy for paying the APC
FX We acknowledge Victor Babes University of Medicine and Pharmacy for
   paying the APC.
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NR 25
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR 21
PY 2025
VL 15
IS 4
AR 511
DI 10.3390/life15040511
PG 16
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 1YM0A
UT WOS:001476647400001
PM 40283066
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Jenkins, S
   Komber, M
   Mattam, K
   Briffa, N
AF Jenkins, Sam
   Komber, Mohamed
   Mattam, Kavitha
   Briffa, Norman
TI Negative pressure wound therapy in patients with diabetes undergoing
   left internal thoracic artery harvest: A randomized control trial
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 102nd Annual Meeting of the American-Association-for-Thoracic-Surgery
   (AATS)
CY MAY 14-17, 2022
CL Boston, MA
SP Amer Assoc Thorac Surg
DE Key Words; coronary artery bypass graft; incisional tive pressure wound
   therapy; left internal thoracic artery; near-infrared spectroscopy;
   randomized control trial; cal site infection
ID NEAR-INFRARED SPECTROSCOPY; SURGICAL-SITE INFECTIONS; VACUUM-ASSISTED
   CLOSURE; TISSUE OXYGEN-SATURATION; STAPHYLOCOCCUS-AUREUS; COLORECTAL
   SURGERY; NASAL CARRIAGE; RISK; WALL
AB Background: Patients with diabetes undergoing CABG are at risk of wound tion. Incisional negative pressure wound therapy has been shown to be effective decreasing incidence of infection in high-risk wounds. Near infrared spectroscopy (NIRS) can be used to assess wound oxygenation and low values can infection. Objectives: To evaluate utility of NIRS to assess wound oxygenation, to fect of sternotomy, left internal thoracic artery harvest, and wound dressing wound edge oxygenation. Methods: In this blinded randomized control trial, patients with diabetes ing isolated coronary artery bypass grafting with a left internal thoracic artery randomized to receive either incisional negative pressure wound therapy or a standard dressing. NIRS measurements were made on the left upper trol), and left and right parasternal regions on day -1 (preoperative), day 5, after surgery. Results were analyzed using repeated measures parametric methods. Results: Eighty patients with diabetes were recruited, 40 to the incisional pressure wound therapy group and 40 to the standard dressing group. NIRS readings dropped significantly in all patients by day 5 and partially by week 6. In both groups, there was no difference between readings on the right. At all time points and on both sides, there was no difference in readings tween patients in the 2 groups. Conclusions: NIRS can be used to assess oxygenation adjacent to a sternotomy wound. Adjusted tissue oxygen levels change with time after sternotomy internal thoracic artery harvest in patients with diabetes. Wound dressing does not influence day 5 wound edge oxygenation. (J Thorac Cardiovasc 2024;167:256-68)
C1 [Jenkins, Sam; Briffa, Norman] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, England.
   [Komber, Mohamed; Mattam, Kavitha; Briffa, Norman] Sheffield Teaching Hosp, NHS Fdn Trust, Dept Cardiothorac Surg, Sheffield, England.
   [Briffa, Norman] Sheffield Teaching Hosp, Northern Gen Hosp, Dept Cardiothorac Surg, Chesterfield Wing,Herries Rd, Sheffield S5 7AU, S Yorkshire, England.
C3 University of Sheffield; University of Sheffield; Oxford University
   Hospitals NHS Foundation Trust; Northern General Hospital; University of
   Sheffield
RP Briffa, N (通讯作者)，Sheffield Teaching Hosp, Northern Gen Hosp, Dept Cardiothorac Surg, Chesterfield Wing,Herries Rd, Sheffield S5 7AU, S Yorkshire, England.
EM n.briffa@sheffield.ac.uk
RI ; Briffa, Norman/N-5386-2014
OI Jenkins, Sam/0000-0003-1941-2892; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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   Grauhan O, 2013, J THORAC CARDIOV SUR, V145, P1387, DOI 10.1016/j.jtcvs.2012.09.040
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NR 33
TC 4
Z9 4
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD JAN
PY 2024
VL 167
IS 1
BP 256
EP 268
DI 10.1016/j.jtcvs.2022.01.060
EA DEC 2023
PG 13
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA DT0X3
UT WOS:001134217700001
PM 35550716
DA 2026-07-24
ER

PT J
AU Cao, J
   Liu, ZX
   Ma, DY
   Shen, SY
   Wang, XD
AF Cao, Jian
   Liu, Zhixu
   Ma, Dongyang
   Shen, Shunyao
   Wang, Xudong
TI Modified Usage of Negative Pressure Wound Therapy for the Management of
   Severe Deep Fascial Space Infections in the Head and Neck
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE negative pressure wound therapy; severe deep fascial space infections;
   modified usage; head and neck
ID VACUUM-ASSISTED CLOSURE
AB Purpose: Although negative pressure wound therapy (NPWT) has been widely used in complicated wound care, there are still some obstacles regarding its use in the treatment of severe deep fascial space infections in the head and neck. The purpose of this study is to describe a new modified usage of NPWT and investigate the clinical efficacy of this system in a consecutive case series of severe deep fascial space infections.
   Methods: The investigators implemented a new modification of NPWT for the management of severe deep fascial space infections. In this new system, the half-plugged bar-shaped foam material was arranged along with the through-and-through side-holed latex drainage tube, which could maintain negative pressure in the distal part of the spaces, and the tube was easy to remove 5-7 days after surgery. Twelve patients had severe deep fascial space infections in the head and neck with a direct threat to the airway. The median time of removal of the NPWT device, the median amount of drainage fluid and the median healing time were investigated.
   Results: A total of 7 male and 5 female patients with an average age of 63.2 years old were included in this study. The median time of removal of the NPWT device was 6 days (ranging from 4 to 7 days). The median amount of drainage fluid within 3 days after surgery was 420 mL (ranging from 280-760 mL), and the median time for complete wound healing was 12 days (ranging from 10 to 21 days).
   Conclusion: The results of this study suggest that the modification of NPWT provides various advantages and leads to excellent clinical outcomes in the treatment of severe deep fascial space infections. Future studies will focus on the safety verification of portable usage and the cost effectiveness analysis of NPWT.
C1 [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oral & Craniomaxillofacial Surg, Coll Stomatol,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Natl Clin Res Ctr Oral Dis, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Key Lab Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Liu, Zhixu; Shen, Shunyao; Wang, Xudong] Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Cao, Jian; Ma, Dongyang] 940th Hosp Peoples Liberat Army, Dept Oral & Maxillofacial Surg, Lanzhou, Gansu, Peoples R China.
C3 Shanghai Jiao Tong University
RP Wang, XD (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Oral & Craniomaxillofacial Surg, Coll Stomatol,Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Natl Clin Res Ctr Oral Dis, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Shanghai Key Lab Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.; Wang, XD (通讯作者)，Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM xudongwang70@hotmail.com
FU Ninth People's Hospital affiliated to Shanghai JiaoTong University,
   School of Medicine "Multi-Disciplinary Team" Clinical Research Project
   [2017-1-005]; Integrated Fund Project of Ninth People's Hospital;
   Clinical Research Plan of SHDC [16CR3019A]; Interdisciplinary Program of
   Shanghai Jiao Tong University [YG2017ZD03]
FX This study was supported by Ninth People's Hospital affiliated to
   Shanghai JiaoTong University, School of Medicine "Multi-Disciplinary
   Team" Clinical Research Project (2017-1-005), the Integrated Fund
   Project of Ninth People's Hospital, the Clinical Research Plan of SHDC
   (16CR3019A), and the Interdisciplinary Program of Shanghai Jiao Tong
   University (YG2017ZD03).
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NR 17
TC 13
Z9 15
U1 1
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2020
VL 13
BP 781
EP 788
DI 10.2147/IDR.S243794
PG 8
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA KX0GE
UT WOS:000521560800001
PM 32210592
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yan, YF
   Li, WF
   Song, Y
   Yin, P
   He, ZZ
   Gong, YP
   Peng, LL
AF Yan, Yafeng
   Li, Wenfeng
   Song, Yan
   Yin, Pei
   He, Zongze
   Gong, Yanping
   Peng, Lili
TI Semiclosure wound therapy plus negative pressure wound therapy for an
   older patient with grade 4 diabetic foot with concomitant vascular
   occlusion A case report
SO MEDICINE
LA English
DT Article
DE grade 4 diabetic foot; infection; negative pressure wound therapy; older
   patient; semiclosure of the wound
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; MULTICENTER; PREVENTION; ULCERS
AB Rationale: Grade 4 diabetic foot (DF) is a severe infection that causes bone destruction, osteomyelitis, and osteoarticular damage, which, in turn, can lead to serious dry or wet gangrene, or amputation. DF is extremely difficult to treat.
   Patient concerns: A 71-year-old female patient with long-term diabetes complicated with uremia, who undergoes regular hemodialysis 2 to 3 times per week, was admitted with grade 4 DF with Pseudomonas aeruginosa infection, and concomitant vascular occlusion of the lower extremities. The patient had a concurrent nutrition and electrolyte disorder.
   Diagnoses: The patient was diagnosed with type 2 diabetes, grade 4 DF, postamputation of the 2nd toe, vascular occlusion of the lower extremities, atherosclerosis, uremia, hypoproteinemia, and electrolyte disturbances.
   Interventions: Treatment with antibiotics and comprehensive measures aimed at improving nutrition and microcirculation, controlling blood glucose, as well as balancing electrolytes were performed to ameliorate the general conditions. Nibbled debridement was used to remove devitalized tissues each time to maintain as much vital cells as possible. Open therapy was used for necrotic tissues, and dressings therapy was used simultaneously for the infected lesion. This combined treatment, involving open therapy with dressing, is referred to as "semiclosure wound therapy." Negative pressure wound therapy (NPWT) was used after a fistula formed.
   Outcomes: During the treatment procedure, the gangrene 3rd toe was spontaneously shed; the necrotic 1st toe was removed by surgery. The wound gradually healed after 3 months of open therapy combined with dressing. High location amputation was avoided.
   Lessons: Semiclosure, which constitutes open therapy combined with the use of dressings, plus NPWT can preserve vital skin cells in the wound and control the aggravation of the infection. It is an effective and novel measure that prevents DF amputation in old patient and promotes wound union.
C1 [Yan, Yafeng; Gong, Yanping; Peng, Lili] Chinese People Liberat Army Gen Hosp, Med Ctr 2, Dept Geriatr Endocrinol, Beijing, Peoples R China.
   [Yan, Yafeng; Gong, Yanping] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China.
   [Li, Wenfeng] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Orthoped, Beijing, Peoples R China.
   [Song, Yan; Yin, Pei; He, Zongze] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Nephrol, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital
RP Gong, YP (通讯作者)，Chinese People Liberat Army Gen Hosp, Natl Clin Res, Ctr Geriatr Dis, Med Ctr 2, Beijing, Peoples R China.
EM gypmrp@163.com
FU Military Logistics Research Projects of China [CWS13J054]; Translational
   Medicine Projects of the Chinese People's Liberation Army General
   Hospital [2017TM-021]; Clinical Scientific Research Support Funds of the
   Chinese People's Liberation Army General Hospital [2018 FC - WJFWZX
   -1-13]
FX This study was supported by the Military Logistics Research Projects of
   China (No. CWS13J054), the Translational Medicine Projects of the
   Chinese People's Liberation Army General Hospital (No. 2017TM-021), and
   the Clinical Scientific Research Support Funds of the Chinese People's
   Liberation Army General Hospital (2018 FC - WJFWZX -1-13).
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   Wound Ostomy Continence Nurses Society-Wound Guidelines Task ForceWOCN, 2017, J WOUND OSTOMY CONT, V44, P214
NR 15
TC 2
Z9 4
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2019
VL 98
IS 44
AR e17786
DI 10.1097/MD.0000000000017786
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JO7BV
UT WOS:000497731800111
PM 31689851
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wagner, JC
   Wetz, A
   Wiegering, A
   Lock, JF
   Löb, S
   Germer, CT
   Klein, I
AF Wagner, Johanna C.
   Wetz, Anja
   Wiegering, Armin
   Lock, Johan F.
   Lob, Stefan
   Germer, Christoph-Thomas
   Klein, Ingo
TI Successful surgical closure of infected abdominal wounds following
   preconditioning with negative pressure wound therapy
SO LANGENBECKS ARCHIVES OF SURGERY
LA English
DT Article
DE Surgical site infections; Secondary skin closure; Negative pressure
   wound therapy; Open wound treatment
ID VACUUM-ASSISTED CLOSURE; SITE INFECTION; SECONDARY INTENTION; OPEN
   ABDOMEN; COMPLICATIONS; IMPACT; MANAGEMENT; HERNIA; COSTS; INDEX
AB Purpose Traditionally, previous wound infection was considered a contraindication to secondary skin closure; however, several case reports describe successful secondary wound closure of wounds "preconditioned" with negative pressure wound therapy (NPWT). Although this has been increasingly applied in daily practice, a systematic analysis of its feasibility has not been published thus far. The aim of this study was to evaluate secondary skin closure in previously infected abdominal wounds following treatment with NPWT. Methods Single-center retrospective analysis of patients with infected abdominal wounds treated with NPWT followed by either secondary skin closure referenced to a group receiving open wound therapy. Endpoints were wound closure rate, wound complications (such as recurrent infection or hernia), and perioperative data (such as duration of NPWT or hospitalization parameters). Results One hundred ninety-eight patients during 2013-2016 received a secondary skin closure after NPWT and were analyzed and referenced to 67 patients in the same period with open wound treatment after NPWT. No significant difference in BMI, chronic immunosuppressive medication, or tobacco use was found between both groups. The mean duration of hospital stay was 30 days with a comparable duration in both patient groups (29 versus 33 days, p = 0.35). Interestingly, only 7.7% of patients after secondary skin closure developed recurrent surgical site infection and in over 80% of patients were discharged with closed wounds requiring only minimal outpatient wound care. Conclusion Surgical skin closure following NPWT of infected abdominal wounds is a good and safe alternative to open wound treatment. It prevents lengthy outpatient wound therapy and is expected to result in a higher quality of life for patients and reduce health care costs.
C1 [Wagner, Johanna C.; Wetz, Anja; Wiegering, Armin; Lock, Johan F.; Lob, Stefan; Germer, Christoph-Thomas; Klein, Ingo] Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.
   [Wiegering, Armin; Lock, Johan F.; Lob, Stefan; Germer, Christoph-Thomas; Klein, Ingo] Comprehens Canc Ctr Mainfranken, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Wagner, JC (通讯作者)，Univ Hosp Wurzburg, Dept Gen Visceral Transplantat Vasc & Pediat Surg, Oberduerrbacherstr 6, D-97080 Wurzburg, Germany.
EM Wagner_J6@ukw.de
RI Wagner, Johanna/KOD-4870-2024; Klein, Ingo/AAY-3371-2020; Lock,
   Johan/AAA-8114-2020; Wiegering, Armin/X-7541-2018
OI Wagner, Johanna/0000-0002-2999-6900; Klein, Ingo/0000-0003-1097-0986;
   Lock, Johan/0000-0002-9007-3937; Wiegering, Armin/0000-0001-7777-0909
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 43
TC 8
Z9 10
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1435-2443
EI 1435-2451
J9 LANGENBECK ARCH SURG
JI Langenbecks Arch. Surg.
PD NOV
PY 2021
VL 406
IS 7
BP 2479
EP 2487
DI 10.1007/s00423-021-02221-w
EA JUN 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WU6XB
UT WOS:000662867000001
PM 34142218
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Yao, M
   Fabbi, M
   Hayashi, H
   Park, N
   Attala, K
   Gu, GS
   French, MA
   Driver, VR
AF Yao, Min
   Fabbi, Matteo
   Hayashi, Hisae
   Park, Nanjin
   Attala, Khaled
   Gu, Gousheng
   French, Michael A.
   Driver, Vickie R.
TI A retrospective cohort study evaluating efficacy in high-risk patients
   with chronic lower extremity ulcers treated with negative pressure wound
   therapy
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Negative pressure wound therapy; Wound healing; Comorbidities; Low
   extremity chronic ulcers; Early intervention
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; CHRONIC VENOUS
   INSUFFICIENCY; DIABETIC FOOT ULCERS; LIMB SALVAGE; IMPACT; COSTS; CARE;
   MULTICENTER; MANAGEMENT
AB The purpose of this study was to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with standard of care on wound healing in high-risk patients with multiple significant comorbidities and chronic lower extremity ulcers (LEUs) across the continuum of care settings. A retrospective cohort study of real-world' high-risk patients was conducted using Boston University Medical Center electronic medical records, along with chart abstraction to capture detailed medical history, comorbidities, healing outcomes and ulcer characteristics. A total of 342 patients, 171 NPWT patients with LEUs were matched with 171 non-NPWT patients with respect to age and gender, were included in this cohort from 2002 to 2010. The hazard ratios (HRs) were estimated by COX proportional hazard models after adjusting for potential confounders. The NPWT patients were 263 times (95% CI = 187-370) more likely to achieve wound closure compared with non-NPWT patients. Moreover, incidence of wound closure in NPWT patients were increased in diabetic ulcers (HR = 326, 95% CI = 221-483), arterial ulcers (HR = 227, CI = 156-378) and venous ulcers (HR = 631, 95% CI = 149-266) compared with non-NPWT patients. In addition, wound healing appeared to be positively affected by the timing of NPWT application. Compared with later NPWT users (1 year or later after ulcer onset), early NPWT users (within 3 months after ulcer onset) and intermediate NPWT users (4-12 months after ulcer onset) were 338 and 218 times more likely to achieve wound healing, respectively. This study showed that despite the greater significant comorbidities, patients receiving NPWT healed faster. Early use of NPWT demonstrated better healing. The longer the interval before intervention is with NPWT, the higher the correlation is with poor outcome.
C1 [Yao, Min; Fabbi, Matteo; Hayashi, Hisae; Park, Nanjin; Attala, Khaled; Gu, Gousheng; French, Michael A.; Driver, Vickie R.] VA New England Hlth Care Div, Providence, RI 02908 USA.
   [Yao, Min; Fabbi, Matteo; Hayashi, Hisae; Park, Nanjin; Attala, Khaled; Gu, Gousheng; French, Michael A.] Limb Preservat & Wound Care Res, Ctr Restorat & Regenerat Med, Dept Surg, Providence, RI USA.
   [Yao, Min; Driver, Vickie R.] Boston Med Ctr, Dept Surg, Boston, MA USA.
   [Yao, Min; Driver, Vickie R.] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Driver, Vickie R.] Ctr Restorat & Regenerat Med, Dept Surg, Providence, RI 02908 USA.
C3 Boston Medical Center; Boston University
RP Driver, VR (通讯作者)，VA New England Hlth Care Div, Providence, RI 02908 USA.
EM drvdriver@aol.com
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 32
TC 24
Z9 30
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2014
VL 11
IS 5
BP 483
EP 488
DI 10.1111/j.1742-481X.2012.01113.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA AQ3BY
UT WOS:000342664900005
PM 23163962
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Yuan, Y
   Niu, YH
   Xiao, WD
   Qi, BW
   Hu, X
   Yu, AX
AF Yuan, Ying
   Niu, Yahui
   Xiao, Weidong
   Qi, Baiwen
   Hu, Xiang
   Yu, Aixi
TI The Effect and Mechanism of Negative Pressure Wound Therapy on Lymphatic
   Leakage in Rabbits
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Lymphtic leakage; Lymphorrhea; Lymphocele; Negative pressure wound
   therapy; Rabbit; Animal model
ID INTERSTITIAL FLUID PRESSURE; VACUUM-ASSISTED CLOSURE; CHYLOUS ASCITES;
   COMPLICATIONS; MANAGEMENT; CHYLOTHORAX; CANCER; LYMPHORRHEA; DISSECTION;
   CHYLORRHEA
AB Background: Lymphatic leakage is one of the severe complications after lymphadenectomy. However, efficient treatment it still unclear.
   Materials and methods: We employed inguinal lymphadenectomy and saphenous lymphatic vessel excision to establish a inguinal lymphatic leakage rabbit model. Rabbits with bilateral lymphatic leakage were divided in two groups, which were subject to negative pressure wound therapy (NPWT) on right sides and dressing change on left sides, respectively. Following 7-11 d of treatment, skin thickness and drainage volume were measured. Western blot and RT-PCR were used for analyzing the VEGF-C level. Tissues of wound were dissected and subject to anti-LYVE-1 immunohistochemical for lymphatic average positive staining area percentage and the ratio of lymphatic lumen area evaluation.
   Results: Our lymphatic leakage model showed significant lymph stasis, delayed wound healing, and skin swelling and was confirmed by methylene blue instillation. Using this rabbit model, we found that NPWT could largely promote wound healing and resolution of skin edema. Compared with the dressing change group, the thickness of the dermis layer in the NPWT group was significantly reduced. Western blot and RT-PCR analysis showed a decrease of VEGF-C in the NPWT group. The immunohistochemical result of the NPWT group did not show a significant change in lymphatic average positive staining area percentage, whereas the ratio of lymphatic lumen area was significantly decreased, suggesting that NPWT treatment can significantly compress the dilated lymphatic vessels.
   Conclusions: We successfully established the first clinically relevant lymphatic leakage model in rabbits. NPWT can be an effective treatment for lymphatic leakage via reducing edema and lymphatic stasis by compressing dilated lymph vessels and promoting lymphatic drainage. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Yuan, Ying; Niu, Yahui; Xiao, Weidong; Qi, Baiwen; Hu, Xiang; Yu, Aixi] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University
RP Yu, AX (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM yuaixi666@163.com
FU National Natural Science Foundation of China [81572163]
FX This work was supported by National Natural Science Foundation of China
   (grant number: 81572163).
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NR 41
TC 12
Z9 17
U1 0
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAR
PY 2019
VL 235
BP 329
EP 339
DI 10.1016/j.jss.2018.09.065
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HI9LL
UT WOS:000456777000044
PM 30691814
DA 2026-07-24
ER

PT J
AU Kim, JH
   Kim, HJ
   Lee, DH
AF Kim, Jun-Ho
   Kim, Hyun-Jung
   Lee, Dae-Hee
TI Comparison of the Efficacy Between Closed Incisional Negative-Pressure
   Wound Therapy and Conventional Wound Management After Total Hip and Knee
   Arthroplasties: A Systematic Review and Meta-Analysis
SO JOURNAL OF ARTHROPLASTY
LA English
DT Review
DE closed incisional negative-pressure wound therapy; surgical site
   infection; total hip arthroplasty; total knee arthroplasty; wound
   complication
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; REVISION HIP; ECONOMIC
   BURDEN; COMPLICATIONS; PREVENTION; DRESSINGS; SURGERY; GUIDELINE; INDEX
AB Background: Wound-related problems after total hip arthroplasty (THA) and total knee arthroplasty (TKA) can cause periprosthetic joint infections. We sought to evaluate the effect of closed incisional negative-pressure wound therapy (ciNPWT) on wound complications, skin blisters, surgical site infections (SSIs), reoperations, and length of hospitalization (LOH).
   Methods: Studies comparing ciNPWT with conventional dressings following THA and TKA were systematically searched on MEDLINE, Embase, and the Cochrane Library. Two reviewers performed the study selection, risk of bias assessment, and data extraction. Funnel plots were employed to evaluate publication bias and forest plots to analyze pooled data.
   Results: Twelve studies were included herein. The odds ratios (ORs) for wound complications and SSIs indicated a lack of publication bias. ciNPWT showed significantly lower risks of wound complication (OR, 0.44; 95% confidence interval [CI], 0.22-0.9; P = .027) and SSI (OR, 0.39; 95% CI, 0.23-0.68; P < .001) than did conventional dressings. ciNPWT also yielded a significantly lower reoperation rate (OR, 0.38; 95% CI, 0.21-0.69; P = .001) and shorter LOH (mean difference, 0.41 days; 95% CI, -0.51 to -0.32; P < .001). However, the rate of skin blisters was higher in ciNPWT (OR, 4.44; 95% CI, 2.24-8.79; P < .001).
   Conclusion: Although skin blisters were more likely to develop in ciNPWT, the risks of wound complication, SSI, reoperation, and longer LOH decreased in ciNPWT compared with those in conventional dressings. This finding could alleviate the potential concerns regarding wound-related problems after THA and TKA. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Kim, Jun-Ho; Lee, Dae-Hee] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Orthoped Surg, 81 Irwon Ro, Seoul 06351, South Korea.
   [Kim, Hyun-Jung] Korea Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Korea
   University; Korea University Medicine (KU Medicine)
RP Lee, DH (通讯作者)，Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Orthoped Surg, 81 Irwon Ro, Seoul 06351, South Korea.
RI ; Lee, Dae-Hee/I-9390-2017
OI Kim, Hyun Jung/0000-0003-2018-2385; Lee, Dae-Hee/0000-0003-3147-8763
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NR 47
TC 38
Z9 44
U1 0
U2 6
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD NOV
PY 2019
VL 34
IS 11
BP 2804
EP 2814
DI 10.1016/j.arth.2019.06.020
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA JD0UN
UT WOS:000489692100047
PM 31288945
DA 2026-07-24
ER

PT J
AU de Jesus, LE
   Martins, AB
   Oliveira, PB
   Gomes, F
   Leve, T
   Dekermacher, S
AF de Jesus, Lisieux Eyer
   Martins, Alana Bandeira
   Oliveira, Pablo Baptista
   Gomes, Fernanda
   Leve, Thais
   Dekermacher, Samuel
TI Negative pressure wound therapy in pediatric surgery: How and when to
   use
SO JOURNAL OF PEDIATRIC SURGERY
LA English
DT Review
DE NPWT, negative pressure wound therapy; ACS, abdominal compartment
   syndrome; SIH, second intention healing; PSC, Pediatric Surgical Cases;
   ECMO, extracorporeal membrane oxygenation
ID VACUUM-ASSISTED CLOSURE; NECROTIZING ENTEROCOLITIS; ABDOMINAL CLOSURE;
   COMPLEX WOUNDS; OPEN ABDOMEN; MANAGEMENT; CHILDREN; EXPERIENCE; INFANTS;
   LAPAROTOMY
AB Introduction: Negative pressure wound therapy (NPWT) has been widely adopted to treat laparostomy, abdominal compartment syndrome (ACS) and complicated wounds associated with tissue loss. The method presents specific aspects, advantages and indications in Pediatrics. Our aim is to review the evidence available about NPWT in children.
   Methods: Active search for papers about NPWT in Pediatric patients. Papers referring to orthopedic problems, wound complications after Cardiac Surgery or burns were excluded.
   Results: The method shows good results to treat ACS, complicated wounds and abdominal wall malformations in neonates, including prematures. Periwound skin protection, monitoring of fluid losses and fine tuning of negative pressure levels according to age are necessary. Less pain, quicker recovery, less frequent dressing changes, possible recovery of exposed surgical hardware, granulation and shrinkage of the wound are advantages of the method over other kinds of dressing. NPWT is contraindicated over blood vessels and exposed nerves. Debridement is needed before usage over necrotic areas. Enteric fistulae are not contraindications. Complications are rare, mainly foam retention and dermatitis/skin maceration. The possibility of fistulae being caused by NPWT remains debatable.
   Conclusion: NPWT is widely used in Pediatrics, including neonates and premature, but the evidence available about the method is scarce and low quality. Complications are uncommon and mostly manageable. A possible causal relationship between NPWY and enteric fistula remains unclear. Adult devices and parameters have been adapted to children's use. Extra care is needed to protect the delicate tissues of Pediatric patients. Comparative research to define differential costs, indications and advantages of the method, specific indications and limits of NWTP in Pediatrics is needed.
   Type of study: Review.
   Evidence level: IV (c) 2017 Elsevier Inc. All rights reserved.
C1 [de Jesus, Lisieux Eyer; Martins, Alana Bandeira; Oliveira, Pablo Baptista; Gomes, Fernanda; Leve, Thais; Dekermacher, Samuel] Minist Hlth, Serv Estado Fed Hosp, Pediat Surg & Urol Dept, Rio De Janeiro, Brazil.
RP de Jesus, LE (通讯作者)，52 Presidente Domiciano Apt 801, BR-24210270 Rio De Janeiro, RJ, Brazil.
EM lisieux@uol.com.br
RI de Jesus, Lisieux/H-3811-2014
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NR 42
TC 36
Z9 40
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0022-3468
EI 1531-5037
J9 J PEDIATR SURG
JI J. Pediatr. Surg.
PD APR
PY 2018
VL 53
IS 4
BP 585
EP 591
DI 10.1016/j.jpedsurg.2017.11.048
PG 7
WC Pediatrics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Surgery
GA GB8CF
UT WOS:000429301400001
PM 29241963
DA 2026-07-24
ER

PT J
AU Lee, SYC
   Bayan, L
   Sato, A
   Vankayalapati, DK
   Antoniou, V
   Shami, MZ
   Sulaiman, HO
   Yap, N
   Nakanishi, H
   Than, CA
   Wong, KY
AF Lee, Sum-Yu Christina
   Bayan, Laith
   Sato, Alma
   Vankayalapati, Dilip K.
   Antoniou, Valeria
   Shami, M. Zaid
   Sulaiman, Hafsa Omer
   Yap, Nathanael
   Nakanishi, Hayato
   Than, Christian A.
   Wong, Kai Yuen
TI Benefits of negative pressure wound therapy in skin grafts: A systematic
   review and meta-analysis of randomised controlled trials
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Review
DE Negative pressure wound therapy; NPWT; VAC; Wound dressings; Skin
   grafts; Graft take
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL THERAPY; COST; INSTILLATION;
   INTEGRATION; DRESSINGS; DRAINAGE; NPWT; FOOT; NECK
AB Background: Negative pressure wound therapy (NPWT) is a widely used adjunct for wound healing and an alternative to conventional dressings for skin grafts. This meta-analysis aimed to quantify the effectiveness of NPWT versus conventional dressings in this population through randomised control trials (RCTs). Methods: A literature search in several databases was conducted from inception to October 2023. Eligible studies were RCTs reporting the efficacy and post-operative outcomes of NPWT and non-NPWT (control) in patients >= 18 years with skin grafts. Pooled proportions were analysed using a random-effects model. This review was registered prospectively with PROSPERO (CRD42023471105). Results: Overall, 16 RCTs met the criteria for inclusion in the meta-analysis. This included 411 patients and 401 controls. Compared to conventional dressings, NPWT demonstrated 8.3% higher overall graft take (95% CI: 2.97, 13.63, I2 = 85%), 10.0% higher graft take at -80 mmHg (95% CI: 5.69, 14.34, I2 = 0%), higher graft success rates (OR = 1.86, 95% CI: 1.05, 3.30, I2 = 0%), lower graft loss rates (OR = 0.44, 95% CI: 0.23, 0.85, I2 = 0%), lower complication rates (OR = 0.36, 95% CI: 0.13, 0.99, I2 = 76%) and lower reoperation rates (OR = 0.31, 95% CI: 0.13, 0.72, I2 = 0%). Conclusion: NPWT is a safe and effective approach for dressing skin grafts in adult patients compared to conventional wound dressings. NPWT improved graft take and graft success while reducing graft failure, reoperations and overall complications. (c) 2025 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Lee, Sum-Yu Christina; Bayan, Laith; Sato, Alma; Antoniou, Valeria; Yap, Nathanael; Than, Christian A.] Univ Nicosia, Med Sch, Dept Basic & Clin Sci, CY-2408 Nicosia, Cyprus.
   [Vankayalapati, Dilip K.] Oxford Thames Valley Fdn Sch, Buckinghamshire NHS Trust, Oxford, England.
   [Shami, M. Zaid] HCA Florida Aventura Hosp & Med Ctr, Aventura, FL USA.
   [Sulaiman, Hafsa Omer] Cleveland Clin Fdn, Digest Dis & Surg Inst, Cleveland, OH USA.
   [Yap, Nathanael; Than, Christian A.] St Georges Univ London, London SW17 0RE, England.
   [Nakanishi, Hayato; Than, Christian A.] Mayo Clin, Dept Surg, Rochester, MN USA.
   [Than, Christian A.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Wong, Kai Yuen] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England.
C3 University of Nicosia; Cleveland Clinic Foundation; City St Georges,
   University of London; Mayo Clinic; University of Queensland; University
   of Cambridge
RP Lee, SYC (通讯作者)，Univ Nicosia, UNIC Med Sch, Block A,93 Agiou Nikolaou St, CY-2408 Nicosia, Cyprus.
EM lee.sum@live.unic.ac.cy
OI Lee, Sum-Yu Christina/0000-0001-7584-1662; Wong, Kai
   Yuen/0000-0002-6060-1487; Vankayalapati, Dilip
   Kumar/0000-0002-1531-7401; Than, Christian/0000-0002-4193-9925;
   Antoniou, Valeria/0009-0001-6086-6151; Sato, Alma/0009-0006-5904-9927;
   Shami, M Zaid/0009-0002-9161-056X
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NR 62
TC 7
Z9 9
U1 2
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1748-6815
EI 1878-0539
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAR
PY 2025
VL 102
BP 204
EP 217
DI 10.1016/j.bjps.2025.01.036
EA JAN 2025
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X6K5O
UT WOS:001426414800001
PM 39932531
DA 2026-07-24
ER

PT J
AU Mayer, D
   Hasse, B
   Koelliker, J
   Enzler, M
   Veith, FJ
   Rancic, Z
   Lachat, M
AF Mayer, Dieter
   Hasse, Barbara
   Koelliker, Jeannette
   Enzler, Markus
   Veith, Frank J.
   Rancic, Zoran
   Lachat, Mario
TI Long-Term Results of Vascular Graft and Artery Preserving Treatment With
   Negative Pressure Wound Therapy in Szilagyi Grade III Infections Justify
   a Paradigm Shift
SO ANNALS OF SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; CURRENT OPTIONS; GROIN;
   EXPERIENCE; PRESERVATION; MANAGEMENT; SURGERY; BYPASS; TRIAL
AB Objective: To present the first long-term results of Szilagyi III vascular infections treated by negative pressure wound therapy (NPWT) with graft preservation.
   Background Data: Szilagyi III infections are usually treated by graft/artery excision and secondary vascular/plastic reconstruction. Small series treated with NPWT without graft removal are reported with good short-term to midterm results.
   Methods: The outcomes of 44 polymorbid patients (mean age = 62 years) with Szilagyi III infections from 2002 to 2009 were analyzed. Thirteen of forty-four required intensive care unit treatment. Forty grafts (prosthetic = 24, vein = 3, biological = 13) and 9 native arteries were involved. Negative pressure wound therapy (VAC; KCI International, Amstelveen, Netherlands) was applied directly on grafts/arteries (negative pressure = 50-125 mm Hg) after radical debridement of infected tissue. Antibiotic treatment was initiated and adapted according to microbiology.
   Results: Median duration of NPWT was 33 days (IQR: 20-78), of hospital stay 32 (IQR: 20-82) days. All patients survived 30 days. One-year mortality was 16% (7/44). Long-term mortality after a mean follow-up of 43 months (SD: 21) was 41% (18/44).
   Complete wound healing was achieved in 91% (40/44). In 37 of 44 patients, grafts were preserved long-term without reinfection. There was no statistically significant difference in outcome between the various graft types involved.
   Conclusions: Vascular graft/arterial preserving treatment with NPWT in Szilagyi III infections was safe and effective with a very low short-term mortality. The majority of infected grafts were preserved without reinfection during a mean long-term follow-up of 4 years. This new treatment algorithm avoids major reconstructive surgery and should be used when dealing with Szilagyi III vascular infections.
C1 [Mayer, Dieter; Koelliker, Jeannette; Veith, Frank J.; Rancic, Zoran; Lachat, Mario] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, CH, Switzerland.
   [Hasse, Barbara] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, CH, Switzerland.
   [Enzler, Markus] Vasc Ctr Hirslanden, Zurich, CH, Switzerland.
   [Veith, Frank J.] Cleveland Clin, New York, NY USA.
   [Veith, Frank J.] NYU Med Ctr, New York, NY 10016 USA.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; Cleveland Clinic Foundation; New York
   University
RP Mayer, D (通讯作者)，Univ Zurich Hosp, Cardiovasc Surg Clin, Raemistr 100, CH-8091 Zurich, CH, Switzerland.
EM dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Mayer, Dieter/E-7617-2011; Hasse,
   Barbara/T-1054-2017
OI Lachat, Mario/0000-0001-7812-2110; Mayer, Dieter/0000-0001-5933-7749;
   Hasse, Barbara/0000-0001-7196-3734
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NR 51
TC 54
Z9 60
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-4932
J9 ANN SURG
JI Ann. Surg.
PD NOV
PY 2011
VL 254
IS 5
BP 754
EP 760
DI 10.1097/SLA.0b013e3182365864
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 844IK
UT WOS:000296740700011
PM 21997817
DA 2026-07-24
ER

PT J
AU Wu, MF
   Matar, DY
   Yu, Z
   Chen, ZY
   Knoedler, S
   Ng, B
   Darwish, O
   Haug, V
   Friedman, L
   Orgill, DP
   Panayi, AC
AF Wu, Mengfan
   Matar, Dany Y.
   Yu, Zhen
   Chen, Ziyu
   Knoedler, Samuel
   Ng, Brian
   Darwish, Oliver
   Haug, Valentin
   Friedman, Leigh
   Orgill, Dennis P.
   Panayi, Adriana C.
TI Modulation of Lymphangiogenesis in Incisional Murine Diabetic Wound
   Healing Using Negative Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE wound healing; incisional wound; NPWT; negative pressure wound therapy;
   lymphatics; lymphangiogenesis; diabetic wound; tissue regeneration
ID VACUUM-ASSISTED CLOSURE; LYMPHATIC-SYSTEM; MANAGEMENT; INFLAMMATION;
   VEGF
AB Objective: Despite the significant function of lymphatics in wound healing, and frequent clinical use of Negative Pressure Wound Therapy (NPWT), the effect of mechanical force application on lymphangiogenesis remains to be elucidated. We utilize a murine incisional wound healing model to assess the mechanisms of lymphangiogenesis following NPWT.Approach: Dorsal incisional skin wounds were created on diabetic mice (genetically obese leptin receptor-deficient mice [db/db]; n = 30) and covered with an occlusive dressing (Control, n = 15) or NPWT (-125 mmHg, continuous, 24 h for 7 days; NPWT, n = 15). The wounds were macroscopically assessed for 28 days. Tissue was harvested on day 10 for analysis. Qualitative functional analysis of lymphatic drainage was performed on day 28 using Evans Blue staining (n = 2).Results: NPWT increased lymphatic vessel density (40 +/- 20 vs. 12 +/- 6 podoplanin [PDPN](+) and 25 +/- 9 vs. 14 +/- 8 lymphatic vessel endothelial receptor 1 [LYVE-1](+)) and vessel diameter (28 +/- 9 vs. 12 +/- 2 mu m). Western blotting verified the upregulation of LYVE-1 with NPWT. Leukocyte presence was higher with NPWT (22% +/- 3.7% vs. 9.1% +/- 4.1% lymphocyte common antigen [CD45](+)) and the leukocytes were predominately B cells clustered within vessels (8.8% +/- 2.5% vs. 18% +/- 3.6% B-lymphocyte antigen CD20 [CD20](+)). Macrophage presence was lower in the NPWT group. Lymphatic drainage was increased in the NPWT group, which exhibited greater Evans Blue positivity.Innovation: The lymphangiogenic effects take place independent of macrophage infiltration, appearing to correlate with B cell presence.Conclusion: NPWT promotes lymphangiogenesis in incisional wounds, significantly increasing the lymph vessel density and diameter. This study highlights the potential of NPWT to stimulate lymphatic drainage and wound healing of surgical incisions.
C1 [Wu, Mengfan; Matar, Dany Y.; Chen, Ziyu; Knoedler, Samuel; Ng, Brian; Darwish, Oliver; Haug, Valentin; Friedman, Leigh; Orgill, Dennis P.; Panayi, Adriana C.] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA USA.
   [Wu, Mengfan] Peking Univ Shenzhen Hosp, Dept Plast Surg, Shenzhen, Peoples R China.
   [Matar, Dany Y.] Washington Univ St Louis, Dept Med, St Louis, MO USA.
   [Yu, Zhen] Jinan Univ, Shenzhen Eye Hosp, Opthalmol Dept, Shenzhen Key Ophthalm Lab, Shenzhen, Peoples R China.
   [Yu, Zhen] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Ophthalmol Dept, Angiogenesis Lab, Boston, MA USA.
   [Knoedler, Samuel] Tech Univ Munich, Dept Plast Surg & Hand Surg, Klinikum Rechts Isar, Munich, Germany.
   [Ng, Brian] St Louis Univ, Dept Med, Sch Med, St Louis, MO USA.
   [Darwish, Oliver] Calif Northstate Univ, Dept Med, Coll Med, Elk Grove, CA USA.
   [Haug, Valentin; Panayi, Adriana C.] Heidelberg Univ, Burn Ctr, BG Trauma Ctr Ludwigshafen, Dept Hand Plast & Reconstruct Surg,Microsurg, Ludwigshafen, Germany.
   [Friedman, Leigh] Lehigh Univ, Dept Med, Bethlehem, PA USA.
   [Friedman, Leigh] Drexel Univ, Coll Med, Dept Med, 75 Francis St, Philadelphia, PA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Peking University; Washington
   University (WUSTL); Jinan University; Shenzhen Eye Hospital; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts Eye & Ear Infirmary; Technical University of
   Munich; Saint Louis University; Ruprecht Karls University Heidelberg;
   Lehigh University; Drexel University
RP Panayi, AC (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Dept Surg, 75 Francis St, Boston, MA 02115 USA.; Panayi, AC (通讯作者)，Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA.
EM apanayi@bwh.harvard.edu
RI Panayi, Adriana/HHT-0513-2022; Orgill, Dennis/H-7596-2019; Knoedler,
   Samuel Alfons/IZQ-4210-2023; Haug, Valentin/ADF-7566-2022
OI Panayi, Adriana/0000-0003-4053-9855; Orgill, Dennis/0000-0002-8279-7310;
   Matar, Dany/0000-0001-7108-0413; Knoedler, Samuel
   Alfons/0000-0001-5798-8003; Yu, Zhen/0000-0003-3456-3584; Wu,
   Mengfan/0000-0003-2646-3372; Chen, Ziyu/0000-0001-5562-7554
FU NIH [5 T35 HL11084]; Gillian Reny Stepping Strong Center for Trauma
   Innovation award; 3M+KCI award
FX This work is funded, in part, by NIH 5 T35 HL11084 fellowship award to
   L.F., and a Gillian Reny Stepping Strong Center for Trauma Innovation
   award and 3M+KCI award to D.P.O.
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NR 44
TC 7
Z9 8
U1 2
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD SEP 1
PY 2023
VL 12
IS 9
BP 483
EP 497
DI 10.1089/wound.2022.0074
EA JAN 2023
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA J5HH1
UT WOS:000913068800001
PM 36424821
DA 2026-07-24
ER

PT J
AU Burusapat, C
   Sringkarawat, S
AF Burusapat, Chairat
   Sringkarawat, Sophilak
TI Efficacy of Negative-Pressure Wound Therapy with
   Tetrachlorodecaoxygen-Anion Complex Instillation Compared with Standard
   Negative-Pressure Wound Therapy for Accelerated Wound Healing: A
   Prospective, Randomized, Controlled Trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SALINE INSTILLATION; BACTERIAL COUNTS;
   DOUBLE-BLIND; RECOMMENDATIONS; MECHANISM; OUTCOMES; IMPACT; AGENT
AB Background: Negative-pressure wound therapy (NPWT) with instillation is a novel wound therapy. The optimal solution is still being investigated. Tetrachlorodecaoxygen-anion complex (TCDO) causes increased phagocytosis and oxygenation. The authors' objective was to investigate the efficacy of NPWT with TCDO instillation (NPWTi) and to compare the results with NPWT alone.
   Methods: A randomized controlled trial was conducted. Inclusion criteria were wound size greater than 4 cm(2) and depth greater than 10 mm. Exclusion criteria were malignancy, immunocompromise, and allergy to TCDO. Patients were randomized into NPWT and NPWTi groups. Outcome measurements consisted of wound surface area, depth, volume, tissue culture, and pathologic evaluation.
   Results: A total of 24 patients in each group were enrolled. The percentages of wound surface area reduction of NPWTi and NPWT groups were 24.1 +/- 6.8 and 28.2 +/- 7.6 on day 12, and 19.0 +/- 6.6 and 22.7 +/- 7.8 on day 15, respectively (p < 0.05). The percentages of wound depth reduction were 16.4 +/- 5.3 and 22.5 +/- 10.5 on day 12, and 12.0 +/- 6.7 and 14.1 +/- 8.0 on day 15, respectively (p < 0.05). The percentages of wound volume reduction were 17.9 +/- 4.6 and 21.6 +/- 5.8 on day 12, and 14.7 +/- 6.0 and 17.1 +/- 6.6 on day 15, respectively (p < 0.05). No statistically significant difference in microbial reduction was found between the groups. Histopathologic examination showed that more angiogenesis was observed in the NPWTi group than in the NPWT group.
   Conclusions: NPWT with TCDO instillation statistically significantly accelerated wound healing, but it did not show significant microbial reduction. The authors' results suggest that TCDO instillation may be an adjunctive treatment in NPWT.
C1 [Burusapat, Chairat] Phramongkutklao Hosp, Div Plast & Reconstruct Surg, Dept Surg, 315 Ratchawithi Rd, Bangkok 10400, Thailand.
   Phramongkutklao Coll Med, Bangkok, Thailand.
C3 Phramongkutklao Hospital; Phramongkutklao College of Medicine
RP Burusapat, C (通讯作者)，Phramongkutklao Hosp, Div Plast & Reconstruct Surg, Dept Surg, 315 Ratchawithi Rd, Bangkok 10400, Thailand.
EM pataranat@hotmail.com
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NR 42
TC 6
Z9 7
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD AUG
PY 2021
VL 148
IS 2
BP 339
EP 352
DI 10.1097/PRS.0000000000008233
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TR4ZQ
UT WOS:000678974600059
PM 34153022
DA 2026-07-24
ER

PT J
AU Colli, A
AF Colli, Andrea
TI First experience with a new negative pressure incision management system
   on surgical incisions after cardiac surgery in high risk patients
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
DE incision; wound healing; negative pressure wound therapy; cardiac
   surgery; median sternotomy
ID STERNAL WOUND COMPLICATIONS; VACUUM-ASSISTED CLOSURE; LONG-TERM
   SURVIVAL; BYPASS GRAFT-SURGERY; SITE INFECTIONS; THERAPY; MEDIASTINITIS;
   IMPACT; RESISTANCE; MORTALITY
AB Background: Sternal wound infection remains a serious potential complication after cardiac surgery. A recent development for preventing wound complications after surgery is the adjunctive treatment of closed incisions with negative pressure wound therapy. Suggested mechanisms of preventive action are improving the local blood flow, removing fluids and components in these fluids, helping keep the incision edges together, protecting the wound from external contamination and promoting incision healing. This work reports on our initial evaluation and clinical experience with the Prevena (TM) Incision Management System, a recently introduced new negative pressure wound therapy system specifically developed for treating closed surgical incisions and helping prevent potential complications. We evaluated the new treatment on sternal surgical incisions in patients with multiple co-morbidities and consequently a high risk for wound complications.
   Methods: The Prevena (TM) incision management system was used in 10 patients with a mean Fowler risk score of 15.1 [Range 8-30]. The negative pressure dressing was applied immediately after surgery and left in place for 5 days with a continuous application of -125 mmHg negative pressure. Wounds and surrounding skin were inspected immediately after removal of the Prevena (TM) incision management system and at day 30 after surgery.
   Results: Wounds and surrounding skin showed complete wound healing with the absence of skin lesions due to the negative pressure after removal of the Prevena (TM) dressing. No device-related complications were observed. No wound complications occurred in this high risk group of patients until at least 30 days after surgery.
   Conclusions: The Prevena (TM) system appears to be safe, easy to use and may help achieve uncomplicated wound healing in patients at risk of developing wound complications after cardiothoracic surgery.
C1 [Colli, Andrea] Hosp Badalona Germans Trias & Pujol, Dept Cardiac Surg, Badalona, Spain.
   [Colli, Andrea] Univ Padua, Cardiac Surg Unit, Dept Cardiol Thorac & Vasc Sci, Padua, Italy.
C3 Hospital Germans Trias i Pujol; University of Padua
RP Colli, A (通讯作者)，Hosp Badalona Germans Trias & Pujol, Dept Cardiac Surg, Badalona, Spain.
EM colli.andrea.bcn@gmail.com
RI Colli, Andrea/G-4858-2011
OI Colli, Andrea/0000-0003-2724-3961
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NR 32
TC 79
Z9 87
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD DEC 6
PY 2011
VL 6
AR 160
DI 10.1186/1749-8090-6-160
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 916KB
UT WOS:000302100400001
PM 22145641
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Levit, T
   Olaiya, O
   Lavoie, DCT
   Avram, R
   Coroneos, CJ
AF Levit, Tal
   Olaiya, Oluwatobi
   Lavoie, Declan C. T.
   Avram, Ronen
   Coroneos, Christopher J.
TI The Use of Negative Pressure Wound Therapy for Breast Surgeries: A
   Systematic Review and Meta-Analysis
SO PLASTIC SURGERY
LA English
DT Review
DE negative-Pressure wound therapy; vacuum-Assisted closure;
   negative-Pressure dressings; breast; traitement par pression n &
   eacute;gative; traitement des plaies; fermeture assist & eacute;e par le
   vide; pansements sous pression n & eacute;gative; sein
ID ABDOMINAL DONOR-SITE; FLAP NECROSIS; COMPLICATIONS; PREVENTION;
   MANAGEMENT
AB Background: Negative pressure wound therapy (NPWT) following breast surgery has emerged as a promising intervention theorized to reduce complication rates, improve patient-important outcomes, and enhance cost-effectiveness. This systematic review and meta-analysis aims to determine outcomes of NPWT following breast surgery. Methods: MEDLINE, Embase, CINAHL, Web of Science, and CENTRAL were searched to include all English-language, peer-reviewed observational and randomized controlled trials (RCTs) investigating NPWT on the breast or donor site among patients undergoing breast surgery. Studies evaluated at least one of the following outcomes: wound dehiscence, surgical site infection (SSI), implant loss, re-operation, re-admission, hematoma, seroma, and skin/wound necrosis. Quality of evidence was assessed with GRADE methodology. Results: This review includes 31 studies (eight RCTs, 23 observational) analyzing 3320 patients (4326 breasts). High certainty of evidence indicates decreased risk of wound dehiscence among NPWT patients in RCTs for all NPWT application sites (donor: 0.40; 95%CI 0.21, 0.79; breast: 0.59; 95%CI 0.41, 0.84) and observational trials where NPWT was placed on donor sites (0.64; 95%CI 0.42, 0.98). Some evidence indicates NPWT may reduce SSI, hematoma, seroma, and skin/wound necrosis incidence, however results are uncertain and varied in statistical significance. No effect was identified on rates of breast implant loss, re-operation, and re-admission, although this certainty of evidence is very low. Conclusions: Our findings suggest NPWT following breast surgery reduces the risk of wound dehiscence, may have some effect on SSIs, hematoma, seroma, and skin/wound necrosis; and does not demonstrate an effect on rates of implant loss, re-operation or re-admission.
C1 [Levit, Tal; Lavoie, Declan C. T.] McMaster Univ, Michael G DeGroote Sch Med, Hamilton, ON, Canada.
   [Levit, Tal; Olaiya, Oluwatobi; Avram, Ronen; Coroneos, Christopher J.] McMaster Univ, Dept Surg, Div Plast Surg, Hamilton, ON, Canada.
   [Coroneos, Christopher J.] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
C3 McMaster University; McMaster University; McMaster University
RP Coroneos, CJ (通讯作者)，McMaster Univ, Juravinski Hosp & Canc Ctr, Dept Surg, Div Plast Surg, 711 Concess St, Hamilton, ON L8V 1C3, Canada.; Coroneos, CJ (通讯作者)，McMaster Univ, Juravinski Hosp & Canc Ctr, Dept Hlth Res Methods Evidence & Impact, 711 Concess St, Hamilton, ON L8V 1C3, Canada.
EM coronec@mcmaster.ca
RI Coroneos, Christopher/AAQ-2460-2021; Levit, Tal/MTD-1593-2025
OI Olaiya, Oluwatobi R/0000-0001-6632-9595; Levit, Tal/0000-0003-3196-4411
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NR 60
TC 4
Z9 4
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2292-5503
EI 2292-5511
J9 PLAST SURG-CHIR PLAS
JI Plast. Surg.
PD MAY
PY 2026
VL 34
IS 2
BP 185
EP 200
DI 10.1177/22925503251336253
EA MAY 2026
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4FJ
UT WOS:001491077200001
PM 40443408
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Deng, YX
   Wang, XC
   Xia, ZY
   Wan, MY
   Jiang, DY
AF Deng, Yun-Xiang
   Wang, Xiao-Chuan
   Xia, Zhen-Yu
   Wan, Meng-Ya
   Jiang, Du-Yin
TI Efficacy and safety of negative pressure wound therapy for the treatment
   of diabetic foot ulcers: A meta-analysis
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Negative pressure wound therapy; Diabetic foot ulcer; Wound healing;
   Amputation; Adverse events; Meta-analysis
ID VACUUM-ASSISTED CLOSURE; MULTICENTER
AB BACKGROUND Diabetic foot ulcers (DFUs) are a significant challenge in diabetic care, and the efficacy of negative pressure wound therapy (NPWT) in treating them remains a subject of continuous investigation. AIM To provide a comprehensive meta-analysis of the role of NPWT in the management of DFUs. METHODS A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, searching databases like PubMed, Embase, Web of Science, and the Cochrane Library. Randomized clinical trials (RCTs) were included to compare NPWT to other dressings for DFUs. Outcomes measured were wound healing time and rate, granulation tissue formation time, amputation rate, and adverse events. Study quality was evaluated using Cochrane's risk of bias tool. Analyses utilized chi 2, I2, fixed or random-effects models via Stata v17. RESULTS Of the 1101 identified articles, 9 RCTs were selected for meta-analysis. Studies spanned from 2005 to 2020 and originated from countries including the United States, Chile, Pakistan, Italy, India, and Germany. Meta-analysis demonstrated a significant improvement in wound healing rate [risk ratio (RR) = 1.46, 95%CI: 1.22-1.76, P < 0.01] and a reduction in amputation rate (RR = 0.69, 95%CI: 0.50-0.96, P = 0.006) with NPWT. Furthermore, the time for granulation tissue formation was significantly reduced by an average of 19.54 days. However, the incidence of adverse events did not significantly differ between NPWT and control treatments. CONCLUSION NPWT significantly improves wound healing rates and reduces amputation rates in DFUs. It also hastens the formation of granulation tissue. However, the therapy does not significantly alter the risk of adverse events compared to alternate treatments.
C1 [Deng, Yun-Xiang; Xia, Zhen-Yu; Wan, Meng-Ya] Shandong Univ, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China.
   [Wang, Xiao-Chuan] Second Hosp Shandong Univ, Dept Plast Surg & Burns, Jinan 250033, Shandong, Peoples R China.
   [Jiang, Du-Yin] Second Hosp Shandong Univ, Emergency Med Ctr, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University
RP Jiang, DY (通讯作者)，Second Hosp Shandong Univ, Emergency Med Ctr, 247 Beiyuan St, Jinan 250033, Shandong, Peoples R China.
EM duyinjiang0227@yeah.net
FU National Natural Science Foundation of China [82202454, 81873934]; Wang
   Zhengguo Trauma Medicine Fund [SZYZ-TR-09]; Shandong Provincial Natural
   Science Foundation Youth Fund [ZR2020QH168]; Jinan Science and
   Technology Plan Project [202225065]
FX Supported by the National Natural Science Foundation of China, No.
   82202454 and No. 81873934; the Wang Zhengguo Trauma Medicine Fund
   (Growth Factor Revival Plan) No. SZYZ-TR-09; the Shandong Provincial
   Natural Science Foundation Youth Fund, No. ZR2020QH168; and the Jinan
   Science and Technology Plan Project, No. 202225065.
CR Akkus G, 2022, WORLD J DIABETES, V13, P1106, DOI 10.4239/wjd.v13.i12.1106
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NR 28
TC 5
Z9 6
U1 1
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUN 15
PY 2025
VL 16
IS 6
AR 103520
DI 10.4239/wjd.v16.i6.103520
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3VM7K
UT WOS:001509994900024
PM 40548270
OA Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Duricová, J
   Brozmanová, H
   Jurica, J
   Kacírová, I
   Sistík, P
   Kanková, K
   Tomásková, H
   Kolek, M
AF Duricova, Jana
   Brozmanova, Hana
   Jurica, Jan
   Kacirova, Ivana
   Sistik, Pavel
   Kankova, Klara
   Tomaskova, Hana
   Kolek, Martin
TI Clindamycin, Ciprofloxacin, and Co-trimoxazole Wound Penetration in
   Open-Heart Surgery Patients Receiving Negative Pressure Wound Therapy
   for Deep Sternal Wound Infection: A Single-Center Prospective
   Observational Study
SO BRATISLAVA MEDICAL JOURNAL
LA English
DT Article
DE Ciprofloxacin; Clindamycin; Co-trimoxazole; Deep sternal wound
   infection; Negative pressure wound therapy; Wound penetration
ID VACUUM-ASSISTED CLOSURE; TISSUE PENETRATION; CARDIAC-SURGERY;
   RISK-FACTORS; PHARMACOKINETICS; MEDIASTINITIS; MICROBIOLOGY; MANAGEMENT;
   VANCOMYCIN; IMPACT
AB Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 +/- 1.43) than for total clindamycin concentrations (0.83 +/- 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 +/- 0.35 vs. 0.81 +/- 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 +/- 20 days) than in those without infection (14 +/- 12 days; p < 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.
C1 [Duricova, Jana; Brozmanova, Hana; Kacirova, Ivana; Sistik, Pavel] Univ Hosp Ostrava, Inst Lab Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Duricova, Jana; Brozmanova, Hana; Kacirova, Ivana; Sistik, Pavel] Univ Ostrava, Fac Med, Dept Clin Pharmacol, Ostrava, Czech Republic.
   [Jurica, Jan] Masaryk Univ, Fac Med, Fac Pharm, Dept Pharmacol,Dept Pharmacol & Toxicol, Brno, Czech Republic.
   [Jurica, Jan] Masaryk Mem Canc Inst, Hosp Pharm, Brno, Czech Republic.
   [Kankova, Klara; Kolek, Martin] Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.
   [Tomaskova, Hana] Univ Ostrava, Fac Med, Dept Epidemiol & Publ Hlth, Ostrava, Czech Republic.
   [Kolek, Martin] Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
C3 University Hospital Ostrava; University of Ostrava; Masaryk University;
   Masaryk Memorial Cancer Institute; University Hospital Ostrava;
   University of Ostrava; University of Ostrava
RP Kolek, M (通讯作者)，Univ Hosp Ostrava, Dept Cardiac Surg, 17 Listopadu 1790-5, Ostrava 70852, Czech Republic.; Kolek, M (通讯作者)，Univ Ostrava, Fac Med, Dept Clin Subjects, Ostrava, Czech Republic.
EM martin.kolek@fno.cz
RI Jurica, Jan/T-2645-2017; Kacirova, Ivana/I-4241-2016; Tomaskova,
   Hana/JCE-4509-2023; Brozmanova, ./G-9793-2019; Kolek, Martin/D-4115-2018
OI Jurica, Jan/0000-0002-0257-6711; Kacirova, Ivana/0000-0001-6618-754X;
   Tomaskova, Hana/0000-0002-9608-1276; Kolek, Martin/0000-0002-0418-3006
FU Ministerstvo Zdravotnictv Cesk Republiky [FNOs/2021]; Ministry of
   Health, Czech Republic-conceptual development of research organization
   [CZ.10.03.01/00/22_003/0000003]; European Union; Faculty of Medicine,
   University of Ostrava
FX This study was supported by the Ministry of Health, Czech
   Republic-conceptual development of research organization (FNOs/2021).
   This article has been produced with the financial support of the
   European Union, under the LERCO project number
   CZ.10.03.01/00/22_003/0000003 via the Operational Programme Just
   Transition. The authors thank Professor Milan Grundmann (Department of
   Clinical Pharmacology, University Hospital Ostrava and Faculty of
   Medicine, University of Ostrava, Czech Republic) for his valuable expert
   advice and consultation.
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NR 35
TC 0
Z9 0
U1 3
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PD AUG
PY 2025
VL 126
IS 8
BP 1891
EP 1903
DI 10.1007/s44411-025-00194-6
EA MAY 2025
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5KW7W
UT WOS:001495243100001
OA gold
DA 2026-07-24
ER

PT J
AU Fowler, AL
   Barry, MK
AF Fowler, Amy Lee
   Barry, Michael Kevin
TI Closed incision negative pressure therapy: Results of recent trials and
   recommendations for clinical practice
SO SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND
   IRELAND
LA English
DT Article
DE Negative pressure wound therapy; Closed incisio; Laparotomy; Open
   abdominal surgery; Surgical site infection; Postoperative complication
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; WOUND THERAPY;
   LAPAROTOMY INCISIONS; PREVENTION; MANAGEMENT; SYSTEM; IMPACT
AB Background: Open abdominal surgery is associated with high rates of wound complications Surgical site infection (SSI) is associated with prolonged length of stay, delayed treatment and high rates of readmission((1, 3, 4)). Negative pressure wound therapy over closed in- cisions (ciNPWT) is a novel approach to prevention of SSI. We reviewed the outcomes of studies comparing ciNPWT and standard therapy in open abdominal wounds to assess the efficacy of the current evidence base.
   Aim: To assess the effect of negative pressure wound therapy used over closed incisions in open abdominal surgery.
   Methods: Search of relevant terms was conducted on PubMed, Scopus and Cochrane to identify studies published between Jan 2006-Feb 2019. Studies were chosen based on specific inclusion criteria. Articles were screened to assess demographics, study design and outcomes.
   Results: Seven retrospective and six prospective randomised controlled trials were identified for inclusion, totalling 3048 participants. 967 received ciNPWT and 2081 received standard treatment. Studies assessed a mix of surgeries (colorectal n = 6, pancreaticoduodenectomy n = 1, gynaecologic n = 1, acute care surgery n = 1, mixed open n = 2). ciNPWT was statistically significant in reducing SSI in 9 of 13 studies.
   Conclusion: ciNPWT in open abdominal surgery has demonstrated promising results for reducing SSI rate in some trials however, patient selection remains unclear. Recent randomized controlled trials have failed to demonstrate benefit overall with use of ciNPWT in open abdominal surgery. Further multicentre prospective trials are needed for cost-benefit analysis and appropriate patient-selection. (C) 2019 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.
C1 [Fowler, Amy Lee; Barry, Michael Kevin] Natl Univ Ireland, Discipline Surg, Galway, Ireland.
   [Fowler, Amy Lee; Barry, Michael Kevin] Royal Coll Surgeons Ireland, Dept Surg Affairs, 121-122 St Stephens Green, Dublin 2, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Royal College of Surgeons in
   Ireland - RCSI
RP Barry, MK (通讯作者)，Natl Univ Ireland, Discipline Surg, Galway, Ireland.
EM kbarsurg@gmail.com
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NR 47
TC 12
Z9 12
U1 0
U2 1
PU ROYAL COLLEGE SURGEONS EDINBURGH
PI EDINBURGH
PA NICOLSON ST, EDINBURGH EH8 9DW, SCOTLAND
SN 1479-666X
EI 2405-5840
J9 SURG-J R COLL SURG E
JI Surg. J. R. Coll. Surg. Edinb. Irel.
PD AUG
PY 2020
VL 18
IS 4
BP 241
EP 250
DI 10.1016/j.surge.2019.10.007
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QE0MR
UT WOS:000615902300009
PM 31822387
DA 2026-07-24
ER

PT J
AU Peinemann, F
AF Peinemann, Frank
TI Negative Pressure Wound Therapy: Randomised Controlled Trials from 2000
   to 2015
SO ZENTRALBLATT FUR CHIRURGIE
LA German
DT Article
DE systematic reviews; evidence-based medicine; randomised trials; negative
   pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; REVIEWS
AB Background Negative pressure wound therapy is believed to promote wound healing. However, the results from randomised controlled trials (RCTs) are inconsistent. Systematic reviews indicate unclear evidence, due in part to low-quality RCTs, calling for more RCTs of higher quality.
   Methods This study aimed to ascertain the number of RCTs as well as systematic reviews on RCTs published during the time period from 2000 to 2015. Various search strategies were used to identify studies in PubMed, Cochrane Library, Google, references lists of retrieved articles, and institutions that issue evidence reports. The study also aimed to investigate the quality of included RCTs. It evaluated whether or not the randomisation methodology was comprehensibly described and conclusions were based on acceptable endpoints.
   Results The search for studies resulted in 456 different references, which included a total of 49 RCTs and 81 systematic reviews. Randomisation was comprehensibly described in 37% (18 out of 49 RCTs) and concealment of allocation in 10% (5 out of 49 RCTs). Conclusions were based on acceptable endpoints in 55% (27 out of 49 RCTs). A superior efficacy of NPWT versus standard was stated in 65% (32 out of 49 RCTs). In studies based on acceptable endpoints, this proportion was 16% (8 out of 49 RCTs). Systematic reviews repeatedly included identical study data.
   Conclusion The published literature, reviewed over a period of more than 16 years, contains more systematic reviews incorporating secondary data from other RCTs than actual RCTs reporting primary clinical data. Many RCTs seem to be of low quality, which considerably limits the validity of the corresponding conclusions. The ongoing production of potentially unreliable RCTs and redundant systematic reviews does not seem to provide convincing answers to crucial clinical research questions. Therefore, a change in strategy should be contemplated to observe individual characteristics of the respective persons and the wounds in question.
C1 [Peinemann, Frank] Uniklin Koln, Klin Kinder & Jugendmed, Kerpener Str 62, D-50937 Cologne, Germany.
C3 University of Cologne
RP Peinemann, F (通讯作者)，Uniklin Koln, Klin Kinder & Jugendmed, Kerpener Str 62, D-50937 Cologne, Germany.
EM pubmedprjournal@gmail.com
RI /H-2800-2019
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NR 26
TC 3
Z9 3
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0044-409X
EI 1438-9592
J9 ZBL CHIR
JI Zent.bl. Chir.
PD JUN
PY 2017
VL 142
IS 3
BP 267
EP 274
DI 10.1055/s-0043-104697
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FD5UW
UT WOS:000407596300017
PM 28641353
DA 2026-07-24
ER

PT J
AU Bruhin, A
   Ferreira, F
   Chariker, M
   Smith, J
   Runkel, N
AF Bruhin, A.
   Ferreira, F.
   Chariker, M.
   Smith, J.
   Runkel, N.
TI Systematic review and evidence based recommendations for the use of
   Negative Pressure Wound Therapy in the open abdomen
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Negative Pressure Wound Therapy (NPWT); Open abdomen; Temporary
   abdominal closure; Evidence-based recommendations; Systematic review
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; DAMAGE-CONTROL
   LAPAROTOMY; MEDIATED FASCIAL TRACTION; DELAYED PRIMARY CLOSURE;
   COMPARTMENT SYNDROME; RETROSPECTIVE EVALUATION; FLUID EVACUATION; TRAUMA
   PATIENTS; VENTRAL HERNIA
AB Introduction: Negative Pressure Wound Therapy (NPWT) is widely used in the management of the open abdomen despite uncertainty regarding several aspects of usage. An expert panel was convened to develop evidence-based recommendations describing the use of NPWT in the open abdomen. Methods: A systematic review was carried out to investigate the efficacy of a range of Temporary Abdominal Closure methods including variants of NPWT. Evidence-based recommendations were developed by an International Expert Panel and graded according to the quality of supporting evidence. Results: Pooled results, in non-septic patients showed a 72% fascial closure rate following use of commercial NPWT kits in the open abdomen. This increased to 82% by the addition of a 'dynamic' closure method. Slightly lower rates were showed with use of Wittmann Patch (68%) and home-made NPWT (vac-pack) (58%). Patients with septic complications achieved a lower rate of fascial closure than non-septic patients but NPWT with dynamic closure remained the best option to achieve fascial closure. Mortality rates were consistent and seemed to be related to the underlying medical condition rather than being influenced by the choice of dressing, Treatment goals for open abdomen were defined prior to developing eleven specific evidence-based recommendations suitable for different stages and grades of open abdomen. Discussion and conclusion: The most efficient temporary abdominal closure techniques are NPWT kits with or without a dynamic closure procedure. Evidence-based recommendations will help to tailor its use in a complex treatment pathway for the individual patient. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
C1 [Bruhin, A.] Dept Trauma & Visceral Surg, Luzern, Switzerland.
   [Ferreira, F.] Hosp Pedro Hispano, Matosinhos Porto, Portugal.
   [Chariker, M.] Aesthet Plast Surg Inst, Louisville, KY USA.
   [Smith, J.] Smith & Nephew, Kingston Upon Hull, N Humberside, England.
   [Runkel, N.] Black Forest Hosp, Dept Gen Surg, Villingen Schwenningen, Germany.
   [Runkel, N.] Univ Freiburg, Freiburg, Germany.
C3 Smith & Nephew; University of Freiburg
RP Smith, J (通讯作者)，101 Hessle Rd, Kingston Upon Hull HU3 2BN, N Humberside, England.
EM jennifer.smith@smith-nephew.com
FU SN; Smith Nephew.
FX S&N provided funding for travel and accommodation for all face-to-face
   expert panel meetings, provided support regarding the published
   literature in NPWT, provided support during the drafting of treatment
   goals and recommendations (author JS) and provided medical writing
   services in preparation of this manuscript (JS). The recommendations
   reflect the independent and unbiased views of the panel and the
   consensus derived during the project and the content of the manuscript
   has not been unfairly influenced by Smith & Nephew. The NPWT-Expert
   Panel was supported by Smith & Nephew.
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NR 111
TC 107
Z9 126
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD OCT
PY 2014
VL 12
IS 10
BP 1105
EP 1114
DI 10.1016/j.ijsu.2014.08.396
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AR4XG
UT WOS:000343588800016
PM 25174789
OA hybrid
DA 2026-07-24
ER

PT J
AU Almeida, IR
   Coltro, PS
   Gonçalves, HOC
   Westin, AT
   Almeida, JB
   Lima, RVKS
   Silva, MF
   Farina, JA Jr
AF Almeida, Ivan R.
   Coltro, Pedro S.
   Goncalves, Henrique O. C.
   Westin, Andrezza T.
   Almeida, Juliano B.
   Lima, Renan V. K. S.
   Silva, Marcelo F.
   Farina Junior, Jayme A.
TI The role of negative pressure wound therapy (NPWT) on the treatment of
   pyoderma gangrenosum: A systematic review and personal experience
SO WOUND REPAIR AND REGENERATION
LA English
DT Review
DE negative pressure therapy; pyoderma gangrenosum; surgical treatment;
   systemic treatment; wound healing
ID VACUUM-ASSISTED CLOSURE; NECROTIZING FASCIITIS; SURGICAL INTERVENTION;
   LEG ULCERS; MANAGEMENT; PATHOPHYSIOLOGY; COMBINATION; INFECTION;
   DIAGNOSIS; GRAFT
AB Pyoderma gangrenosum (PG) is a rare painful ulcerative neutrophilic inflammatory skin disease, necessitating a high level of diagnostic suspicion associated with appropriate treatment to avoid progression. Negative pressure wound therapy (NPWT) has been efficiently used in the treatment of different types of wounds. However, the role of NPWT in the management of PG is still controversial, due to the risk of the pathergy phenomenon. In this article, we conducted a systematic review (according to the PRISMA guidelines) on the use of NPWT in the treatment of PG, and we report our personal experience with two patients treated with this device. The result of the review showed that articles on the topic are, in their entirety, of low levels of evidence, such as case series, case reports, and reviews. Improvement in wound healing with the use of NPWT was observed in 85.1% of the patients studied. Besides, a significant association between improvement in wound healing with NPWT and immunosuppressive therapy was observed. Regarding the cases reported here, both showed good outcomes with the use of NPWT and skin graft during the treatment of PG injuries. Due to the rarity of PG, there is a scarcity of studies with robust evidence for standardization and comparison between treatments, which consequently makes it difficult to select therapeutic options. However, based on this systematic review and reported cases, we consider NPWT a safe option for adjuvant treatment of wounds caused by PG if combined with systemic immunosuppression, which plays a key role in greater chances of successful treatment. This approach should be recommended, whenever possible, associated with skin grafting to accelerate wound closure. The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: a systematic review and personal experience.
C1 [Almeida, Ivan R.; Coltro, Pedro S.; Goncalves, Henrique O. C.; Almeida, Juliano B.; Lima, Renan V. K. S.; Silva, Marcelo F.; Farina Junior, Jayme A.] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Plast Surg, Sao Paulo, Brazil.
   [Westin, Andrezza T.] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Dermatol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Coltro, PS (通讯作者)，Univ Sao Paulo, Ribeirao Preto Med Sch, Div Plast Surg, Av Bandeirantes 3900,9th Floor, Ribeirao Preto, SP, Brazil.
EM psc@usp.br
RI Silva, Marcelo/AGR-1056-2022; Coltro, Pedro/P-5349-2014; Farina, Jayme
   A/F-9518-2012
OI de Rezende Almeida, Ivan/0000-0001-7680-4986; Coraspe Gonçalves,
   Henrique Ovidio/0000-0002-7726-0869; Coltro, Pedro/0000-0002-0164-4508;
   Farina, Jayme A/0000-0002-9232-367X
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NR 79
TC 22
Z9 24
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAY
PY 2021
VL 29
IS 3
BP 486
EP 494
DI 10.1111/wrr.12910
EA MAR 2021
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA SC5OP
UT WOS:000633518000001
PM 33772964
DA 2026-07-24
ER

PT J
AU Lee, YN
   Lee, JS
   Han, SK
   Jung, HK
AF Lee, Ye-Na
   Lee, Jong Seok
   Han, Seung-Kyu
   Jung, Hye-Kyung
TI Tissue Oxygenation and Negative-Pressure Wound Therapy When Applied to
   the Feet of Persons With Diabetes Mellitus: An Observational Study
SO JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
LA English
DT Article
DE Diabetic foot; Negative-pressure wound therapy; Tissue oxygenation;
   Transcutaneous oxygen pressure
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; FOOT ULCERS;
   PREDICTIVE-VALUE; DELAY PROCEDURES; AMPUTATION; MACROCIRCULATION;
   VALUES; FLAP; SKIN
AB PURPOSE: Our group has reported that negative-pressure wound therapy (NPWT) decreases tissue oxygenation by 84% in the foot of diabetic patients because the pad of the connecting drainage tube and foam sponge of the NPWT system compress the wound bed. The purpose of this study was to determine whether an NPWT modified dressing application reduces tissue oxygenation in the feet of persons with diabetes mellitus.
   DESIGN: A prospective, clinical, observational study.
   SUBJECTS AND SETTING: We enrolled 30 patients with diabetic mellitus; their mean age was 63.9 11.2 years (mean standard deviation). All were cared for at the diabetic wound center at an academic tertiary medical center in South Korea between 2014 and January 2015.
   METHODS: Transcutaneous partial oxygen pressures (TcpO(2)) were measured to determine tissue oxygenation levels beneath modified NPWT dressings. A TcpO(2) sensor was fixed at the tarsometatarsal area of the contralateral unwounded foot. A negative pressure of -125 mm Hg was applied until TcpO(2) reached a plateau state; values were measured before, during, and after the modified NPWT. The Wilcoxon' and Mann-Whitney U tests were used to compare differences between these measurements.
   RESULTS: TcpO(2) levels decreased by 26% during the modified NPWT. Mean TcpO(2) values before, during, and after turning off the therapy were 54.3 +/- 15.3 mm Hg, 41.6 +/- 16.3 mm Hg, and 53.3 +/- 15.6 mm Hg (P < .05), respectively.
   CONCLUSION: Applying NPWT without the pad of the connecting drainage tube significantly reduces the amount of tissue oxygenation loss beneath foam dressings on the skin of the foot dorsum in diabetic patients.
C1 [Lee, Ye-Na; Lee, Jong Seok; Han, Seung-Kyu; Jung, Hye-Kyung] Korea Univ, Guro Hosp, Diabet Wound Ctr, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Han, SK (通讯作者)，Korea Univ, Guro Hosp, Dept Plast Surg, 148 Guro Dong, Seoul 152703, South Korea.
EM pshan@kumc.or.kr
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NR 27
TC 2
Z9 3
U1 1
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1071-5754
EI 1528-3976
J9 J WOUND OSTOMY CONT
JI J. Wound Ostomy Cont. Nurs.
PD NOV-DEC
PY 2017
VL 44
IS 6
BP 517
EP 523
DI 10.1097/WON.0000000000000378
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FM5MB
UT WOS:000415078100005
PM 29117076
DA 2026-07-24
ER

PT J
AU Suh, H
   Lee, AY
   Park, EJ
   Hong, JP
AF Suh, Hyunsuk
   Lee, A-Young
   Park, Eun Jung
   Hong, Joon Pio
TI Negative Pressure Wound Therapy on Closed Surgical Wounds With Dead
   Space: Animal Study Using a Swine Model
SO ANNALS OF PLASTIC SURGERY
LA English
DT Article
DE negative pressure wound therapy; surgical wound dehiscence; primary
   closure; subcutaneous dead space
ID VACUUM-ASSISTED CLOSURE; RISK-FACTORS; MEDIASTINITIS; MANAGEMENT;
   INFECTIONS; INCISIONS; SURGERY
AB Background Closed incisional wound surgery frequently leaves dead space under the repaired skin, which results in delayed healing. The purpose of this study was to evaluate the effect of negative pressure wound therapy (NPWT) on incisional wounds with dead space after primary closure by evaluating the fluid volume through the suction drain, blood flow of the skin, tensile strength, and histology of the wounds.
   Methods Bilateral 25-cm-long incisional wounds with dead space were created on the back of 6 pigs by partially removing the back muscle and then suturing the skin with nylon sutures. NPWT (experimental group) or gauze dressing (control group) was applied over the closed incision for 7 days. Analysis of the wound included monitoring the amount of closed suction drain, blood perfusion unit, tensile strength of the repaired skin, and histology of the incision site.
   Results The drainage amount was significantly reduced in the experimental group (49.8 mL) compared to the control group (86.2 mL) (P = 0.046). Skin perfusion was increased in the experimental group with statistical significance compared to the control group (P = 0.0175). Collagen staining was increased in the experimental group. The tensile strength of the incision site was significantly higher in the experimental group (24.6 N at 7 days, 61.67 N at 21 days) compared to the control group (18.26 N at 7 days, 50.05 N at 21 days) (P = 0.02).
   Conclusion This study explains some of the mechanism for using NPWT in closed incision wounds with dead space. It demonstrates that NPWT significantly reduces drainage amount, increases skin perfusion, increases tensile strength, and has the tendency to promote collagen synthesis for closed wound with dead space indicating enhanced healing.
C1 [Suh, Hyunsuk] Ewha Womans Univ Hosp, Dept Plast Surg, Seoul, South Korea.
   [Lee, A-Young; Park, Eun Jung; Hong, Joon Pio] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Plast Surg, Seoul, South Korea.
C3 Ewha Womans University; University of Ulsan; Asan Medical Center
RP Hong, JP (通讯作者)，Asan Med Ctr, Dept Plast Surg, Poongnap2 Dong,388-1, Seoul 138736, South Korea.
EM joonphong@amc.seoul.kr
RI Hong, Joon/AEV-0712-2022; SUH, Hyunsuk/ABE-9911-2020
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NR 39
TC 66
Z9 77
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-7043
EI 1536-3708
J9 ANN PLAS SURG
JI Ann. Plast. Surg.
PD JUN
PY 2016
VL 76
IS 6
BP 717
EP 722
DI 10.1097/SAP.0000000000000231
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DN3DU
UT WOS:000376943400022
PM 25003432
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Kaushik, D
   Joshi, N
   Kumar, R
   Gaba, S
   Sapra, R
   Kumar, K
AF Kaushik, D.
   Joshi, N.
   Kumar, R.
   Gaba, S.
   Sapra, R.
   Kumar, K.
TI Negative pressure wound therapy versus gauze dressings for the treatment
   of contaminated traumatic wounds
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE high energy; soft tissue trauma; negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; SOFT-TISSUE
   INJURIES; OPEN FRACTURES; CLINICAL-EXPERIENCE; MANAGEMENT; INFECTION;
   COVERAGE; TIBIA
AB Objective: This compares hospital suction negative pressure wound therapy (NPWT) with conventional gauze dressings in traumatic soft-tissue injury at a tertiary care centre.
   Methods: A prospective control study was conducted between September 2012 and November 2014. Patients with one or more traumatic soft-tissue injuries with contaminated wounds were allocated to either a test group (received NPWT) or control group (received conventional gauze). Wounds were assessed by two orthopaedic surgeons. If grade A was achieved, the wound was covered with split-thickness skin graft, flap or delayed primary closure; otherwise, revision debridement and NPWT/saline gauze dressings were applied. Descriptive statistics (mean, standard deviation and proportions) were used to summarise the study variables. The 95% confidence intervals (CI) for difference of mean were used. Chi-square test and Fisher's exact test were used to observe an association between the qualitative data and outcome variables. Unpaired T-Test and Mann-Whitney U test were used for analysis of the quantitative data. A p<0.05 was considered statistically significant.
   Results: A total of 104 patients were included. The mean number of dressings per patient was significantly lower in the NPWT group (3.4) than in the control group (20.7) (p<0.001). The time between injury and complete closure (12.5 versus 21.4 days) as well as duration of hospital stay (17.3 versus 23.8 days) was significantly less in the NPWT group (p<0.05).
   Conclusion: NPWT has a role in healing traumatic wounds and can be delivered effectively through hospital suction NPWT, which can also reduce the cost of therapy. We recommend its regular use in all patients presenting with post-traumatic, soft-tissue injuries when primary coverage is not possible.
C1 [Kaushik, D.] Safdarjang Hosp, Sports Injury Ctr, New Delhi, India.
   [Joshi, N.; Kumar, R.; Kumar, K.] Sawai Man Singh Med Coll & Hosp, Jaipur, Rajasthan, India.
   [Gaba, S.] AIIMS, Dept Orthopaed, New Delhi, India.
   [Sapra, R.] Bhagwan Mahavir Hosp, Dept Orthopaed, New Delhi, India.
C3 Vardhman Mahavir Medical College & Safdarjung Hospital; SMS Medical
   College & Hospital; All India Institute of Medical Sciences (AIIMS) New
   Delhi
RP Kaushik, D (通讯作者)，Safdarjang Hosp, Sports Injury Ctr, New Delhi, India.
EM devwartkaushik@gmail.com
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NR 40
TC 8
Z9 13
U1 0
U2 18
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD OCT
PY 2017
VL 26
IS 10
BP 600
EP 606
DI 10.12968/jowc.2017.26.10.600
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FI9ZR
UT WOS:000412368800005
PM 28976825
DA 2026-07-24
ER

PT J
AU Wang, T
   He, R
   Zhao, J
   Gu, QS
   Mei, JC
   Shao, MZ
   Pan, Y
   Zhang, J
   Wu, HS
   Yu, M
   Yang, WC
   Liu, LM
   Liu, F
   Jia, WP
AF Wang, Tao
   He, Rui
   Zhao, Jun
   Gu, Qisheng
   Mei, Jiacai
   Shao, Mingzhe
   Pan, Ye
   Zhang, Jian
   Wu, Haisheng
   Yu, Min
   Yang, Wenchao
   Liu, Limei
   Liu, Fang
   Jia, Weiping
TI A prospective cohort study of negative pressure wound therapy combined
   angioplasty for diabetic foot patients with critical limb ischemia
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Negative pressure wound therapy; percutaneous angioplasty; diabetic
   ulcer; critical limb ischemia
ID VACUUM-ASSISTED CLOSURE; BALLOON ANGIOPLASTY; ULCERS; MULTICENTER;
   MANAGEMENT; DISEASE; PREVALENCE
AB To evaluate the clinical efficacy and security of combined negative pressure wound therapy (NPWT) and percutaneous angioplasty (PTA) in the treatment of diabetic foot ulcers with critical limb ischemia (CLI). We enrolled 97 patients from 142 cases suffered from diabetic foot ulcers into this multi-center prospective cohort study. Patients who were assigned to NPWT-PTA (n=56) or NPWT (n=41) group based on standard off-leading therapy as needed, and were followed-up at 8 weeks and 20 weeks, their ankle-brachial pressure index (ABI), wound area, healing time and adverse events were monitored. A multivariate Cox proportional hazards regression analysis was used to determining the risk factors of wound healing. A greater proportion of wound healing in NPWT-PTA group was observed compared with NPWT group (61.5% vs 40.9%, P=0.004) at 20 weeks. The time of wound healing was earlier in NPWT-PTA group than NPWT group (48.3 +/- 32.8 days vs 77.1 +/- 27.1 days, P=0.009) at 20 weeks. ABI in NPWT-PTA group was higher than NPWT group at both 8 weeks (0.83 +/- 0.19 vs 0.46 +/- 0.15, P=0.000) and 20 weeks (0.72 +/- 0.17 vs 0.53 +/- 0.12, P=0.000). The decrease of ABI (HR=15.000, 95% CI=2.243-100.333, P=0.005) and increase of wound area (HR=0.926, 95% CI=0.866-0.990, P=0.025) were independent risk factors of wound healing. There was no significant difference in adverse events between the two groups. Combined NPWT with PTA therapy is effective and safe for diabetic foot ulcers with CLI by increasing the level of ABI, and results in a higher proportion of wounds closure.
C1 [Wang, Tao; Zhao, Jun; Mei, Jiacai; Shao, Mingzhe; Pan, Ye; Zhang, Jian; Wu, Haisheng; Yu, Min; Yang, Wenchao] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Shanghai Clin Med Ctr Diabet, Dept Vasc Surg,Multidisciplinary Collaborat Ctr D, 600 Yishan Rd, Shanghai 200233, Peoples R China.
   [He, Rui; Liu, Limei; Liu, Fang; Jia, Weiping] Shanghai Jiao Tong Univ, Shanghai Key Clin Ctr Metab Dis,Afflliated People, Shanghai Key Lab Diabet,Shanghai Clin Med Ctr Dia, Multidisciplinary Collaborat Grp Diabet Foot,Shan, Shanghai 200233, Peoples R China.
   [Gu, Qisheng] Shanghai Qisheng Inst Biol Mat Res, Shanghai 201100, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Zhao, J (通讯作者)，Shanghai Jiao Tong Univ, Affiliated Peoples Hosp Shanghai 6, Shanghai Clin Med Ctr Diabet, Dept Vasc Surg,Multidisciplinary Collaborat Ctr D, 600 Yishan Rd, Shanghai 200233, Peoples R China.; Liu, F (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Key Clin Ctr Metab Dis,Afflliated People, Shanghai Key Lab Diabet,Shanghai Clin Med Ctr Dia, Multidisciplinary Collaborat Grp Diabet Foot,Shan, Shanghai 200233, Peoples R China.
EM junnzhao@126.com; f-liu@sjtu.edu.cn
RI Jia, Weiping/B-7483-2012; Yang, Wen-Chao/U-1649-2019; Wu,
   Haisheng/KBC-9542-2024; shao, mingzhe/NWH-1124-2025; He,
   Ruijia/MZQ-2297-2025
OI Jia, Weiping/0000-0002-6244-2168; 
FU Natural Science Foundation of China [8127-0397]; Fund of Shanghai Health
   Bureau [201344197]
FX The authors are thankful to Shanghai Key Laboratory of Diabetes for
   providing necessary help for carrying out the research work. The present
   study was supported by grants from Natural Science Foundation of China
   (8127-0397 for Fang Liu) and Fund of Shanghai Health Bureau (No
   201344197 for Jian Zhang).
CR Alexandrescu V, 2009, EUR J VASC ENDOVASC, V37, P448, DOI 10.1016/j.ejvs.2008.12.005
   [Anonymous], 2004, WOUNDS, p3S
   Armstrong DG, 2003, DIABETIC MED, V20, P329, DOI 10.1046/j.1464-5491.2003.00933.x
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 9
BP 17975
EP 17984
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EA5OT
UT WOS:000386671100101
DA 2026-07-24
ER

PT J
AU Eisenhardt, SU
   Schmidt, Y
   Thiele, JR
   Iblher, N
   Penna, V
   Torio-Padron, N
   Stark, GB
   Bannasch, H
AF Eisenhardt, S. U.
   Schmidt, Y.
   Thiele, J. R.
   Iblher, N.
   Penna, V.
   Torio-Padron, N.
   Stark, G. B.
   Bannasch, H.
TI Negative pressure wound therapy reduces the
   ischaemia/reperfusion-associated inflammatory response in free muscle
   flaps
SO JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
LA English
DT Article
DE Free flap surgery; Negative pressure wound therapy;
   Ischaemia/reperfusion injury
ID VACUUM-ASSISTED CLOSURE; ISCHEMIA-REPERFUSION INJURY; RAT SKIN FLAPS;
   ISCHEMIA/REPERFUSION INJURY; CONTROLLED-TRIAL; CELL-DEATH; LIVER;
   APOPTOSIS; MECHANISMS; FOUNDATION
AB Background: We recently established negative pressure wound therapy (NPWT) as a safe postoperative care concept for free muscle flaps; however, the molecular effects of NPWT on free muscle flaps remain elusive. Here we investigated the effects of NPWT on pathological changes associated with ischaemia/reperfusion injury in free flap tissue.
   Methods: From July 2008 to September 2010, 30 patients receiving skin-grafted free muscle transfer for defect coverage were randomly assigned to two treatment groups: In one group the skin-grafted free flap was covered by a vacuum dressing (NPWT); in the second group, flaps were covered by conventional petroleum gauze dressings (conv). Biopsies were taken intraoperatively prior to clipping of the pedicle and on postoperative day 5. Samples were analysed by immunohistochemistry for infiltration of inflammatory cells, real-time polymerase chain reaction (RT-PCR) for the analysis of expression levels of interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF)-alpha as markers of inflammation. Histological samples were also examined for interstitial oedema formation, and apoptosis was detected by a terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay.
   Results: NPWT leads to a significantly reduced tissue infiltration of CD68 + macrophages and reduced expression of the inflammatory cytokines IL-1 beta and TNF alpha. None of these parameters was significantly elevated in the pre-ischaemic biopsies. Furthermore, NPWT reduced the interstitial oedema formation and the number of apoptotic cells in free flap tissue.
   Conclusion: NPWT of skin-grafted free muscle flaps leads to a reduced inflammatory response following ischaemia/reperfusion, resulting in reduced oedema formation improving the microcirculation and ultimately reduced tissue damage. We thereby deliver new insight into the effects of NPWT. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
C1 [Eisenhardt, S. U.; Schmidt, Y.; Thiele, J. R.; Iblher, N.; Penna, V.; Torio-Padron, N.; Stark, G. B.; Bannasch, H.] Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, D-79106 Freiburg, Germany.
C3 University of Freiburg
RP Eisenhardt, SU (通讯作者)，Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM steffen.eisenhardt@uniklinik-freiburg.de
RI Eisenhardt, Steffen Ulrich/AAF-8033-2021
OI Eisenhardt, Steffen Ulrich/0000-0003-4471-3160
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NR 43
TC 75
Z9 89
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1748-6815
J9 J PLAST RECONSTR AES
JI J. Plast. Reconstr. Aesthet. Surg.
PD MAY
PY 2012
VL 65
IS 5
BP 640
EP 649
DI 10.1016/j.bjps.2011.11.037
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 926XD
UT WOS:000302864300024
PM 22137686
DA 2026-07-24
ER

PT J
AU Manoharan, V
   Grant, AL
   Harris, AC
   Hazratwala, K
   Wilkinson, MPR
   McEwen, PJC
AF Manoharan, Varaguna
   Grant, Andrea L.
   Harris, Alicia C.
   Hazratwala, Kaushik
   Wilkinson, Matthew P. R.
   McEwen, Peter J. C.
TI Closed Incision Negative Pressure Wound Therapy vs Conventional Dry
   Dressings After Primary Knee Arthroplasty: A Randomized Controlled Study
SO JOURNAL OF ARTHROPLASTY
LA English
DT Article
DE negative pressure wound therapy; primary knee arthroplasty; quality of
   life; cost; wound complications
ID VACUUM-ASSISTED CLOSURE; SKIN-GRAFTS; HIP; INFECTION; MANAGEMENT;
   SURGERY; REPLACEMENT
AB Background: The purpose of this study was to assess the effect of negative pressure wound therapy (NPWT) on quality of life (QoL), wound complications, and cost after primary knee arthroplasty.
   Methods: A prospective analysis of 33 patients undergoing primary knee arthroplasty performed by 3 surgeons in one institution. The first 12 patients (3 bilateral and 9 unilateral) had conventional dry dressings (CDD) applied and cost of dressings was assessed. The other 21 patients all underwent bilateral knee arthroplasty and had either side randomized to receiving NPWT or CDD. Cost of dressings, wound complications, and QoL were compared.
   Results: One patient had a reaction to the NPWT requiring readmission. Another had persistent wound drainage that required NPWT application. There were no wound issues in the remaining 31 patients. The average cost in the first 12 patients was Australian dollar $48.70 with an average of 1.5 changes on ward. In the 21 patients receiving both dressings, the average cost for CDD was less (Australian dollar $43.51 vs $396.02, P <= .011, effect size [ES] = 1.06). When comparing QoL factors, wound leakage (0.14 vs 0.39 P = .019, ES = 1.02), and wound protection (0.16 vs 0.33, P = .001, ES = 0.021) were better in the NPWT group. There was no other significant difference in QoL factors. The average number of changes on the ward was less for the NPWT group (1.19 vs 1.38, P = .317, ES = 1.02).
   Conclusion: We found no benefit in wound healing or cost with NPWT post knee arthroplasty. There was some benefit in NPWT QoL factors less wound leakage and better protection. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
C1 [Manoharan, Varaguna; Grant, Andrea L.; Harris, Alicia C.; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Orthopaed Res Inst Queensland ORIQL, Pimlico, Qld, Australia.
   [Manoharan, Varaguna; Grant, Andrea L.; Harris, Alicia C.; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Mater Hlth Serv North Queensland Ltd, Pimlico, Qld, Australia.
   [Manoharan, Varaguna; Hazratwala, Kaushik; Wilkinson, Matthew P. R.; McEwen, Peter J. C.] Townsville Hosp, Dept Orthopaed, Townsville, Qld, Australia.
C3 Mater Health Services; Queensland Health; Townsville Hospital
RP Manoharan, V (通讯作者)，Orthopaed Res Inst Queensland, 7 Turner St, Pimlico, Qld 4812, Australia.
RI McEwen, Peter/LIC-3848-2024
OI McEwen, Peter/0000-0001-5499-9532; Hazratwala,
   Kaushik/0000-0002-0649-9231; Grant, Andrea/0000-0002-0568-0872;
   Wilkinson, Matthew/0000-0002-3704-7043
CR [Anonymous], 2012, STRYKER ACCOLADE 2 F
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NR 37
TC 56
Z9 61
U1 0
U2 3
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0883-5403
EI 1532-8406
J9 J ARTHROPLASTY
JI J. Arthroplast.
PD NOV
PY 2016
VL 31
IS 11
BP 2487
EP 2494
DI 10.1016/j.arth.2016.04.016
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EA6OG
UT WOS:000386747900021
PM 27341973
DA 2026-07-24
ER

PT J
AU Bollero, D
   Driver, V
   Glat, P
   Gupta, S
   Lázaro-Martinez, JL
   Lyder, C
   Ottonello, M
   Pelham, F
   Vig, S
   Woo, K
AF Bollero, Daniele
   Driver, Vickie
   Glat, Paul
   Gupta, Subhas
   Lazaro-Martinez, Jose Luis
   Lyder, Courtney
   Ottonello, Manlio
   Pelham, Francis
   Vig, Stella
   Woo, Kevin
TI The Role of Negative Pressure Wound Therapy in the Spectrum of Wound
   Healing
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE negative pressure wound therapy; moist wound healing; traumatic and
   surgical wounds; pressure ulcers; diabetic foot ulcers; venous ulcers
   and arterial ulcers
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; RANDOMIZED
   CONTROLLED-TRIAL; PARTIAL-THICKNESS BURNS; CHRONIC LEG ULCERS;
   SUBATMOSPHERIC PRESSURE; OCCLUSIVE DRESSINGS; ALGINATE DRESSINGS;
   SUPERFICIAL WOUNDS; IONIC SILVER
AB Wound care clinicians have a wide array of available treatment options to manage and help heal acute and chronic complex wounds that require a systematized and comprehensive approach to address the complexity of wound care and to optimize patient outcomes. The treatment of wounds represents a major cost to society. Public policies increasingly focus on quality of care, patient outcomes, and lowering costs. Wound care clinicians are not immune to these pressures. Wound care clinicians must ensure that their assessments, treatment pathways, and product selections are both clinically and economically sound.
   Negative pressure wound therapy (NPWT) has been demonstrated to be an efficacious option to promote healing in a variety of acute and chronic complex wounds. Previous guidelines on the use of NPWT have focused on application but have not provided recommendations on when it is most appropriate to use NPWT; there are few criteria for 1) when to initiate NPWT based on various wound types, 2) pre-application management to optimize treatment outcomes, 3) identification of appropriate candidates for NPWT, 4) benchmark indicators for treatment response, and 5) recommendations on when to transition between NPWT and moist wound healing (MWH) or another treatment mooality.
   In September 2009, an international panel of wound care experts from multiple disciplines convened to develop a document to guide clinicians in making decisions about the appropriate use of NPWT within the spectrum of wound healing. Where empirical research was lacking, clinical experiences and patient factors were considered to ensure the clinical utility of the document. The goal of these guidelines is to encourage responsible wound management across the healthcare continuum and spectrum of wound pathologies to achieve positive, cost-effective patient outcomes.
C1 [Bollero, Daniele] CTO Hosp Torino, Dept Plast Surg Burn Unit, Turin, Italy.
   [Driver, Vickie] Boston Univ, Boston Med Ctr, Boston, MA USA.
   [Glat, Paul] St Christophers Hosp Children, Philadelphia, PA USA.
   [Gupta, Subhas] Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA 92354 USA.
   [Lazaro-Martinez, Jose Luis] Univ Complutense Madrid, Diabet Foot Unit, Madrid, Spain.
   [Lyder, Courtney] Ronald Reagan UCLA Med Ctr, Sch Nursing, Los Angeles, CA USA.
   [Ottonello, Manlio] S Corona Hosp, Spinal Cord Unit, Pietra Ligure, Italy.
   [Pelham, Francis] NYU, Sch Med, Langone Med Ctr, Hosp Joint Dis, New York, NY USA.
   [Vig, Stella] Mayday Univ Hosp, Croydon, England.
   [Woo, Kevin] Univ Toronto, Fac Nursing, Toronto, ON, Canada.
C3 A.O.U. Citta della Salute e della Scienza di Torino; Boston Medical
   Center; Boston University; Loma Linda University; Complutense University
   of Madrid; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; Ronald
   Reagan UCLA Medical Center; NYU Langone Medical Center; Hospital for
   Joint Disease NYULMC; New York University; Croydon University Hospital;
   University of Toronto
RP Gupta, S (通讯作者)，Loma Linda Univ, Med Ctr, Dept Plast Surg, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumac.edu
RI ; Gupta, Subhas/C-5458-2018; MARTINEZ, JOSE/AAE-2268-2021
OI Chhabda, Tejinder/0000-0003-3155-3129; 
CR *AG HEALTHC RES QU, NEG PRESS WOUND THER
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NR 76
TC 19
Z9 22
U1 0
U2 19
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD MAY
PY 2010
SU S
BP 4
EP +
PG 16
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 604GM
UT WOS:000278267500001
DA 2026-07-24
ER

PT J
AU Kalaiselvan, R
   Slade, DAJ
   Soop, M
   Burnett, H
   Lees, NP
   Anderson, ID
   Lal, S
   Carlson, GL
AF Kalaiselvan, Ramya
   Slade, Dominic A. J.
   Soop, Mattias
   Burnett, Hugh
   Lees, Nicholas P.
   Anderson, Iain D.
   Lal, Simon
   Carlson, Gordon L.
TI Impact of negative pressure wound therapy on enteroatmospheric
   fistulation in the septic open abdomen
SO COLORECTAL DISEASE
LA English
DT Article; Proceedings Paper
CT International Surgical Congress of the
   Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY MAY 09-11, 2018
CL Liverpool, ENGLAND
SP Assoc Surg Great Britain & Ireland
DE abdominal sepsis; fistula; intestinal failure
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMINAL WOUNDS; TEMPORARY CLOSURE; OPEN
   MANAGEMENT
AB Aim: The effect of negative pressure wound therapy (NPWT) on the pathogenesis and outcome of enteroatmospheric fistulation (EAF) in the septic open abdomen (OA) is unclear. This study compares the development and outcome of EAF following NPWT with that occurring in the absence of NPWT.
   Methods: Consecutive patients admitted with EAF following abdominal sepsis at a National Reference Centre for intestinal failure between 01 January 2005 and 31 December 2015 were included in this study. Patients were divided into two groups based on those that had been treated with NPWT and those that had not (non-NPWT) and characteristics of their fistulas compared. Clinical outcomes concerning nutritional autonomy at 4 years and time to fistula development, size of abdominal wall defect and complete fistula closure were compared between groups.
   Results: A total of 160 patients were admitted with EAF following a septic abdomen (31-NPWT and 129-non-NPWT). Median (range) time taken to fistulation after OA was longer with NPWT (18 [5-113] vs. 8 [2-60] days, p = 0.004); these patients developed a greater number of fistulas (3 [2-21] vs. 2 [1-10], p = 0.01), involving a greater length of small bowel (42.5 [15-100] cm vs. 30 [3.5-170] cm, p = 0.04) than those who did not receive NPWT. Following reconstructive surgery, nutritional autonomy was similar in both groups (77% vs. 72%) and a comparable number of patients were also fistula-free (100% vs. 97%).
   Conclusions: Negative pressure wound therapy appears to be associated with more complex and delayed intestinal fistulation, involving a greater length of small intestine in the septic OA. This did not, however, appear to adversely affect the overall outcome of intestinal and abdominal wall reconstruction in this study.
C1 [Kalaiselvan, Ramya; Slade, Dominic A. J.; Soop, Mattias; Lees, Nicholas P.; Anderson, Iain D.; Lal, Simon; Carlson, Gordon L.] Salford Royal NHS Fdn Trust, Dept Surg, Natl Reference Ctr Intestinal Failure, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
   [Burnett, Hugh] Christie NHS Fdn Trust, Dept Radiol, Manchester, Lancs, England.
C3 Salford Royal NHS Foundation Trust; Christie NHS Foundation Trust
RP Carlson, GL (通讯作者)，Salford Royal NHS Fdn Trust, Dept Surg, Natl Reference Ctr Intestinal Failure, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
EM gordon.carlson@nca.nhs.uk
RI Soop, Mattias/AAQ-3417-2021; Slade, Dominic/AAE-8585-2022
OI Lal, Simon/0009-0005-9742-4946; Slade, Dominic/0000-0002-6032-8580
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NR 24
TC 1
Z9 1
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8910
EI 1463-1318
J9 COLORECTAL DIS
JI Colorectal Dis.
PD JAN
PY 2023
VL 25
IS 1
BP 111
EP 117
DI 10.1111/codi.16318
EA SEP 2022
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA GZ0A1
UT WOS:000855354200001
PM 36031878
DA 2026-07-24
ER

PT J
AU Yu, AW
   Rippel, RA
   Smock, E
   Jarral, OA
AF Yu, Angela W.
   Rippel, Radoslaw A.
   Smock, Elliott
   Jarral, Omar A.
TI In patients with post-sternotomy mediastinitis is vacuum-assisted
   closure superior to conventional therapy?
SO INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
LA English
DT Article
DE Negative pressure wound therapy; Vacuum-assisted closure therapy; Deep
   sternal wound infection; Cardiac surgical procedures
ID PRESSURE WOUND THERAPY
AB A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether vacuum-assisted closure therapy (VAC) is superior to conventional therapy for treating post-sternotomy mediastinitis. Altogether > 261 papers were found using the reported search, of which 9 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Several studies indicate that VAC therapy is associated with shorter lengths of intensive care and in-hospital stay as well as faster rates of wound healing and fewer dressing changes. It has also been shown that VAC therapy is correlated with a statistically significant reduction in reinfection rates, particularly those that occur in the early postoperative period (at the 1-week follow-up). Patients can be discharged with the dressing in situ and managed in the community with a view to delayed closure or reconstruction. However, the studies comparing VAC with conventional therapy are all retrospective in nature and reinforce the need for randomized controlled trials in order to more accurately establish differences in outcomes between VAC and conventional therapy. Additionally, owing tlo the variability of treatment protocols within the non-VAC arm, it is more challenging to draw definitive conclusions regarding the superiority of VAC therapy to every modality that is considered conventional treatment. We conclude that VAC therapy is a portable and an increasingly economical option for the treatment of post sternotomy mediastinitis. Although reductions in mortality rates were not reproduced in all studies, evidence suggests that VAC should still be considered as a first-line therapy for post-sternotomy mediastinitis and as a bridge therapy to musculocutaneous reconstruction or primary closure.
C1 [Yu, Angela W.; Rippel, Radoslaw A.] UCL, Royal Free & Univ Coll Med Sch, London, England.
   [Smock, Elliott] St George Hosp, Dept Plast Surg, London, England.
   [Jarral, Omar A.] London Chest Hosp, Dept Cardiothorac Surg, London E2 9JX, England.
C3 University of London; University College London; City St Georges,
   University of London; University of London; Queen Mary University London
RP Jarral, OA (通讯作者)，London Chest Hosp, Dept Cardiothorac Surg, London E2 9JX, England.
EM omarjarral@gmail.com
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NR 12
TC 48
Z9 61
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1569-9293
EI 1569-9285
J9 INTERACT CARDIOV TH
JI Interact Cardiovasc. Thorac. Surg.
PD NOV
PY 2013
VL 17
IS 5
BP 861
EP 865
DI 10.1093/icvts/ivt326
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 248TE
UT WOS:000326725300029
PM 23912622
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Bialomyzy, A
   Kotrych, K
   Bogacz, A
   Podralska, M
   Górska, A
   Bialecki, J
   Uzar, I
   Czerny, B
   Kaminski, A
AF Bialomyzy, Agnieszka
   Kotrych, Katarzyna
   Bogacz, Anna
   Podralska, Marta
   Gorska, Aleksandra
   Bialecki, Jacek
   Uzar, Izabela
   Czerny, Boguslaw
   Kaminski, Adam
TI Ozone Therapy and Negative Pressure Wound Therapy in the Treatment of
   Difficult-to-Heal Wounds in Diabetic Foot Syndrome and Charcot
   Neuroarthropathy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE Charcot neuroarthropathy; diabetic foot syndrome; negative pressure
   wound therapy; ozone therapy
ID VACUUM-ASSISTED CLOSURE; ULCERS; RISK
AB Diabetes, as one of the most common diseases of civilization, is a significant factor of mortality worldwide. Undiagnosed and improperly treated, it leads to the development of a number of complications, including diabetic foot syndrome (DFS) and Charcot neuroarthropathy (CN). Charcot neuroarthropathy is a complex and devastating disease characterized by the presence of neuropathy, progressive deformities, and joint destruction. Risk factors and epidemiological data emphasize the high prevalence of CN in the diabetic population, drawing attention to typical predisposing factors for the development of this disease. Serious complications, such as foot ulcers or amputations, show the scale of the negative impact of CN and DFS on the quality of life of patients. Background/Objectives: The aim of the study was to assess the treatment of foot ulcers in patients with DFS and CN using ozone therapy with simultaneous negative pressure wound therapy (NPWT). Methods: The study included 30 patients aged 39 to 87 years with DFS and 30 patients with CN. Ozone therapy and negative pressure wound therapy were used for the treatment of chronic wounds. Results: The analysis of the results showed a significant reduction in the wound size in both study groups; in patients with DFS, a reduction from 5 cm3 to 0.40 cm3 observed after 3 weeks and to 0.002 cm3 after 6 weeks of therapy, while in patients with CN, a reduction from 8 cm3 to 1.50 cm3 was observed after 3 weeks and to 0.004 cm3 after 6 weeks of therapy. No statistically significant differences were observed in median wound sizes between the DFS and CN groups. Ozone therapy with a value of 70 mu g/mL is an effective method in the treatment of chronic diseases of soft tissue and the skeletal system. In combination with NPWT after cleansing the wound of bone sequestrum, the process increased the density of capillaries by accelerating the synthesis of proteins and collagen and reduced bacterial colonization in the wound. Conclusions: The use of ozone therapy procedures at 70 mu g/mL with negative pressure therapy is effective in the prevention and treatment of infectious bone complications in diabetes, such as diabetic foot syndrome and Charcot neuroarthropathy.
C1 [Bialomyzy, Agnieszka] Eter Med Med Ctr Gdansk, Zabi Kruk 10, PL-80822 Gdansk, Poland.
   [Bialomyzy, Agnieszka] Poznan Univ Med Sci, Dept & Clin Gen Endocrine Surg & Gastrointestinal, Przybyszewskiego 49, PL-60355 Poznan, Poland.
   [Kotrych, Katarzyna] Pomeranian Med Univ, Dept Gen & Dent Radiol, Al Powstancow Wielkopolskch 72, PL-70111 Szczecin, Poland.
   [Bogacz, Anna] Poznan Univ Med Sci, Dept Physiol, Smoluchowskiego 11, PL-60179 Poznan, Poland.
   [Podralska, Marta; Gorska, Aleksandra; Czerny, Boguslaw] Inst Nat Fibres & Med Plants, Dept Stem Cells & Regenerat Med, Kolejowa 2, PL-62064 Plewiska, Poland.
   [Bialecki, Jacek] Francis Raszeja Municipal Hosp, Dept Gen Minimally Invas & Trauma Surg, Mickiewicza 2 St, PL-60834 Poznan, Poland.
   [Uzar, Izabela; Czerny, Boguslaw] Pomeranian Med Univ, Dept Pharmacol & Pharmacoecon, PL-71230 Szczecin, Poland.
   [Kaminski, Adam] Pomeranian Med Univ, Dept Children Orthoped & Musculosceletal Oncol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
C3 Poznan University of Medical Sciences; Pomeranian Medical University;
   Poznan University of Medical Sciences; Institute of Natural Fibres &
   Medicinal Plants; Pomeranian Medical University; Pomeranian Medical
   University
RP Bogacz, A (通讯作者)，Poznan Univ Med Sci, Dept Physiol, Smoluchowskiego 11, PL-60179 Poznan, Poland.
EM agnieszka.bialomyzy@gmail.com; kotrych1@gmail.com; aniabogacz23@o2.pl;
   marta.podralska@iwnirz.pl; aleksandra.gorska@iwnirz.pl;
   jacekt.bialecki@gmail.com; uzari@wp.pl; bczerny@wp.pl; emluc@wp.pl
RI ; Czerny, Bogusław/A-9749-2015; Uzar, Izabela/K-5847-2014; Górska,
   Aleksana/OKT-0744-2025
OI Kotrych, Katarzyna/0000-0002-1391-4499; Bogacz,
   Anna/0000-0001-5455-8315; Górska, Aleksana/0000-0001-9833-5738
FU Pomeranian Medical University in Szczecin; Institute of Natural Fibers
   and Medicinal Plants (Poland)
FX The study was supported by statutory projects from Pomeranian Medical
   University in Szczecin and the Institute of Natural Fibers and Medicinal
   Plants (Poland).
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NR 36
TC 2
Z9 2
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN 6
PY 2025
VL 14
IS 12
AR 4017
DI 10.3390/jcm14124017
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4FJ1F
UT WOS:001516691600001
PM 40565762
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lumsden, EJ
   Kimble, RM
   Ware, RS
   Griffin, B
AF Lumsden, Emma J.
   Kimble, Roy M.
   Ware, Robert S.
   Griffin, Bronwyn
TI Tissue Pressure Changes and Implications on Dressing Selection when
   utilising Negative Pressure Wound Therapy on an Ex Vivo Porcine Model
SO BURNS
LA English
DT Article
DE Negative pressure wound therapy; Tissue pressure change; Dressing
   selection; Porcine abbreviations; NPWT; ICP; Intracranial pressure
   transducer
ID VACUUM-ASSISTED CLOSURE; CONTRACTION; FILLERS
AB Negative Pressure Wound Therapy (NPWT) is broadly used in surgical wound management and more recently burn care; however, the tissue pressure changes and best dressing application technique remains unknown. This study was done to help understand the tissue pressure changes beneath negative pressure when varying the delivered pressures, dressing thickness and distribution of dressings. This study was done in 2021 at a quaternary paediatric burns hospital. Utilising a cadaveric porcine model, an intracranial pressure monitor and transducer were used to assess pressure. The transducer was placed on the epidermis or inserted under ultrasound guidance via cannulation to the dermis, subcutaneous or muscular layer. Mepitel (TM), ACTICOAT (TM), varying layers of Kerlix (TM) (10, 20 or 30 layers) and NPWT were then applied either circumferentially or non-circumferentially. Each set of results is indicative of the intracranial pressure probe reading when NPWT was delivered at -40, -60, -80, -100 and -120 mmHg. The median and interquartile pressure recordings were epidermis: -42 (-42.5 - -41), -60.5 (-62.5 - -60), -80.5 (-82 - -80), - 99 (-99 - -98)mmHg (p < 0.001); dermis: 1 (0 - 2), 2 (1 - 3.5), 3 (2 - 5.5), 4 (3 - 7), 5.5 (4 - 7.5)mmHg (p < 0.001) (the increase in pressure was less when circumferential dressings (p < 0.001) or more layers of Kerlix were applied (p < 0.001)); subcutis: 1.5 (-4.5-1), -2.5 (-7.5 - 1.5), -3.5 (-11 - 1.5), -5 (-14 - 1.5) and -6 (-16 - 2)mmHg (p = 006) (the decrease in pressure was less with increased layers of Kerlix (0.047) and muscular: 0 (-0.5 - 0), 0 (-1 - 0.5), 0 (-1 - 1), 0 0 (-1 - 1), 00 (-1.5 - 1)mmHg (p = 0.55). These data suggest negative pressure paradoxically exerts a positive pressure on the dermis. Circumferential and multi-layer dressings reduce this positive pressure. This knowledge has impacted our burn negative pressure wound therapy dressing selection. The limitation of this study is the cadaveric model, a live model is suggested for future studies.
C1 [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Griffith Univ, Fac Hlth, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.] Queensland Childrens Hosp, Dept Paediat Surg Urol Burns & Trauma, Stanley St, South Brisbane, Qld 4101, Australia.
   [Lumsden, Emma J.; Kimble, Roy M.; Griffin, Bronwyn] Ctr Childrens Hlth Res, 62 Graham St, South Brisbane, Qld 4101, Australia.
   [Ware, Robert S.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
C3 Griffith University; Childrens Health Queensland Hospital & Health
   Service; Queensland Childrens Hospital; Griffith University
RP Lumsden, EJ (通讯作者)，62 Graham St, South Brisbane, Qld 4101, Australia.
EM emma.lumsden@health.qld.gov.au
RI Ware, Robert/B-2024-2014; Griffin, Bronwyn/AEB-6299-2022; Kimble,
   Roy/B-4160-2011
OI Ware, Robert/0000-0002-6129-6736; Griffin, Bronwyn/0000-0002-6182-9125; 
CR Almulhim A.M., 2022, Evaluation of postmortem changes
   Anesäter E, 2011, INT WOUND J, V8, P336, DOI 10.1111/j.1742-481X.2011.00790.x
   Anghel EL, 2016, PLAST RECONSTR SURG, V138, p129S, DOI 10.1097/PRS.0000000000002645
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   Cozza V, 2019, WOUND REPAIR REGEN, V27, P190, DOI 10.1111/wrr.12693
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   Surnmerfield A, 2015, MOL IMMUNOL, V66, P14, DOI 10.1016/j.molimm.2014.10.023
NR 20
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD JUN
PY 2024
VL 50
IS 5
BP 1241
EP 1246
DI 10.1016/j.burns.2024.01.023
EA MAY 2024
PG 6
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA C9I6K
UT WOS:001292429800001
PM 38378389
OA gold
DA 2026-07-24
ER

PT J
AU Kheirabadi, BS
   Terrazas, IB
   Williams, JF
   Hanson, MA
   Dubick, MA
   Blackbourne, LH
AF Kheirabadi, Bijan S.
   Terrazas, Irasema B.
   Williams, James F.
   Hanson, Margaret A.
   Dubick, Michael A.
   Blackbourne, Lorne H.
TI Negative-pressure wound therapy: A hemostatic adjunct for control of
   coagulopathic hemorrhage in large soft tissue wounds
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Negative-pressure wound therapy; hemostatic adjunct; coagulopathy; swine
ID VACUUM-ASSISTED CLOSURE; INJURIES; MANAGEMENT
AB BACKGROUND: Negative-pressure wound therapy has been commonly used for treating chronic wounds and recently applied for treatment of traumatic wounds. We investigated the potential hemostatic benefit of negative-pressure wound therapy for control of refractory hemorrhage in a soft tissue wound model in swine.
   METHODS: Coagulopathy was induced in pigs (n = 38, 36 kg) by hemodilution and hypothermia. Next, a large soft tissue wound (diameter, approximately 20 cm) was created by slicing the gluteus maximus muscle. Free bleeding was allowed for 1 minute, and wounds were then randomly dressed with either laparotomy gauze (G) alone or TraumaPad (TP, a kaolin-coated dressing) alone or in combination with negative pressure (NP, approximately -500 mm Hg). All wounds were sealed with adhesive drapes. Fluid resuscitation was administered and targeted to mean arterial pressure of 60 mm Hg. Pigs were observed for 150 minutes or until death after which tissues were sampled for histologic examination.
   RESULTS: Induced coagulopathy as measured by increases in prothrombin time (12%) and activated partial thromboplastin time (22%) and decreases in fibrinogen (48%) were similar in all groups. There were no differences in initial bleeding rates (4.5 mL/kg/min). Dressing the wounds with G or TP produced hemostasis only in one pig (1 of 18 pigs). Addition of NP to these dressings secured hemostasis in 70% (G) and 90% (TP) of animals with average hemostasis time of 34 minutes and 25 minutes, respectively. Blood losses and fluid resuscitation requirements were significantly less, and survival times were significantly longer in NP adjunct groups than in the other groups. Survival rates were 80% (G+NP) and 90% (TP+NP) versus 0% (G) and 10% (TP) in the respective groups. Histologic examination showed similar superficial myofibril damages in all groups.
   CONCLUSION: To our knowledge, the present data provide the first evidence that NP serves as an effective hemostatic adjunct and when combined with standard hemostatic dressing it is able to stop lethal coagulopathic bleeding in large soft tissue wounds. (J Trauma Acute Care Surg. 2012; 73: 1188-1194. Copyright (c) 2012 by Lippincott Williams & Wilkins)
C1 [Kheirabadi, Bijan S.; Terrazas, Irasema B.; Williams, James F.; Hanson, Margaret A.; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Kheirabadi, BS (通讯作者)，3650 Chambers Pass,BHT2,Bldg 3610, Ft Sam Houston, TX 78234 USA.
EM BIJAN.KHEIRABADI@US.ARMY.MIL
FU US Army Medical Research and Materiel Command; Veterinary Support Branch
FX We express our sincere gratitude to Dr. Harold Klemcke for his careful
   review and editorial assistance of the article. We also acknowledge our
   Veterinary Support Branch for their support and assistance in conducting
   these experiments. The excellent technical assistance by Dr. Adekoye
   Sanni (DVM), SPC Birk Greene, and SPC Alice Craig is greatly
   appreciated.The funding for this work was provided solely by the US Army
   Medical Research and Materiel Command.
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Banwell Paul E, 2004, Int Wound J, V1, P95, DOI 10.1111/j.1742-4801.2004.00031.x
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NR 24
TC 10
Z9 10
U1 2
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2012
VL 73
IS 5
BP 1188
EP 1194
DI 10.1097/TA.0b013e31826f98ea
PG 7
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 043VF
UT WOS:000311577100028
PM 23117379
DA 2026-07-24
ER

PT J
AU Carlson, GL
   Patrick, H
   Amin, AI
   McPherson, G
   MacLennan, G
   Afolabi, E
   Mowatt, G
   Campbell, B
AF Carlson, Gordon L.
   Patrick, Hannah
   Amin, Amin I.
   McPherson, Gladys
   MacLennan, Graeme
   Afolabi, Ebenezer
   Mowatt, Graham
   Campbell, Bruce
TI Management of the Open Abdomen A National Study of Clinical Outcome
   and Safety of Negative Pressure Wound Therapy
SO ANNALS OF SURGERY
LA English
DT Article
DE abdominal compartment syndrome; abdominal wall reconstruction;
   intestinal failure; intestinal fistula; laparostomy; negative pressure
   wound therapy; sepsis
ID VACUUM-ASSISTED CLOSURE; TEMPORARY ABDOMINAL CLOSURE; FASCIAL CLOSURE;
   EXPERIENCE; MORTALITY; TRAUMA
AB Objective: To determine clinical outcome of open abdomen therapy and assess the influence of negative pressure wound therapy on outcome.
   Background: Leaving the abdomen open (laparostomy) is an option following laparotomy for severe abdominal sepsis or trauma. Negative pressure wound therapy (NPWT) has become a popular means of managing laparostomy wounds. It may facilitate nursing care and delayed primary wound closure but the evidence to support its use is poor and concern has arisen about the risk of intestinal fistulation from exposed bowel, leading to an increased risk of death.
   Methods: Prospective observational study of 578 patients treated with an open abdomen in 105 hospitals in the United Kingdom between January 1, 2010, and June 30, 2011. Propensity analysis was used to compare adverse outcomes (fistulation, death, intestinal failure, bleeding requiring intervention) and delayed primary closure rates in patients who did and did not receive NPWT.
   Findings: The most common indication for an open abdomen (n = 398, 68.9%) was abdominal sepsis. Overall hospital mortality was 28.2%. The majority of patients (n = 355, 61.4%) were treated with NPWT. Intestinal fistulation [relative risk (RR) = 0.83, 95% confidence interval (CI): 0.44-1.58], death (RR = 0.87, 95% CI: 0.64-1.20), bleeding (RR = 0.74, 95% CI: 0.45-1.23), and intestinal failure (RR = 1.00, 95% CI: 0.64-1.57) were no more common in patients receiving NPWT, but the rate of delayed primary closure was significantly lower (RR = 0.74, 95% CI: 0.60-0.90, P = 0.002) when NPWT was used.
   Conclusions: The indications for an open abdomen in the United Kingdom appear to be significantly different to those described in N. America, where its use in the management of trauma predominates. NPWT in patients with an open abdomen is not associated with an increase in mortality or intestinal fistulation. It is, however, associated with a reduced rate of delayed primary closure. Although this may be related to patient selection, NPWT may leave patients with abdominal wall defects that require further treatment.
C1 [Carlson, Gordon L.] Salford Royal NHS Fdn Trust, Dept Surg, Natl Intestinal Failure Ctr, Salford, Lancs, England.
   [Patrick, Hannah; Campbell, Bruce] Natl Inst Hlth & Clin Excellence, London, England.
   [Amin, Amin I.] Victoria Hosp, Dept Surg, Kirkcaldy, Fife, Scotland.
   [McPherson, Gladys; MacLennan, Graeme; Afolabi, Ebenezer; Mowatt, Graham] Univ Aberdeen, Hlth Serv Res Unit, Aberdeen, Scotland.
   [Campbell, Bruce] Peninsula Coll Med & Dent, Exeter, Devon, England.
C3 Salford Royal NHS Foundation Trust; National Institute for Health & Care
   Excellence; University of Aberdeen; University of Exeter; University of
   Plymouth
RP Carlson, GL (通讯作者)，Salford Royal NHS Fdn Trust, Dept Surg, Eccles Old Rd, Manchester M6 8HD, Lancs, England.
EM gordon.carlson@srft.nhs.uk
OI MacLennan, Graeme/0000-0002-1039-5646; Afolabi,
   Ebenezer/0009-0007-0069-7337
FU National Institute for Health and Clinical Excellence; Chief Scientist
   Office [HSRU1] Funding Source: researchfish
FX This study was supported by National Institute for Health and Clinical
   Excellence. The authors declare no conflicts of interest.
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NR 29
TC 93
Z9 113
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2013
VL 257
IS 6
BP 1154
EP 1159
DI 10.1097/SLA.0b013e31828b8bc8
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 145VP
UT WOS:000319047300034
PM 23478532
DA 2026-07-24
ER

PT J
AU Liu, GH
   Xu, ZY
   Tan, JH
   Li, JX
   Xu, JE
   Tan, XY
   Zhai, JW
   Wu, JY
   Zhong, GH
   Li, MY
AF Liu, Guo-Hua
   Xu, Zhen-Yue
   Tan, Jian-Hui
   Li, Jia-xing
   Xu, Jun-Er
   Tan, Xiao-Yu
   Zhai, Jing-Wei
   Wu, Jia-yuan
   Zhong, Guo-Hui
   Li, Ming-Yi
TI Tapering-pressure VAC therapy for wound exudation in POPF after
   pancreatoduodenectomy: a single-center experience
SO FRONTIERS IN SURGERY
LA English
DT Article
DE postoperative pancreatic fistulas; open pancreaticoduodenectomy;
   laparoscopic pancreaticoduodenectomy; vacuum-assisted closure; wound
   exudation
ID INTERNATIONAL STUDY-GROUP; POSTOPERATIVE PANCREATIC FISTULA;
   PANCREATICOJEJUNOSTOMY; DEFINITION; PANCREATICOGASTROSTOMY; SURGERY;
   CLOSURE
AB Background Pancreaticoduodenectomy(PD) is the only effective treatment for the peri-ampullar carcinoma. However, postoperative pancreatic fistula(POPF) is the most intractable complication causing relevant mortality. Moreover, pancreatic juice may exude from the wound that would lead to more serious complications. Tapering pressure of wall vacuum-assisted closure (VAC) therapy is considered one of the best treatment to wound exudation. Here, we report on a single center series of 5 POPF cases accompanying wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy, successfully managed by VAC.Methods We enrolled all patients who experienced POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy (OPD or LAPD) and received tapering pressure of vacuum-assisted closure (VAC) therapy between July 2017 and August 2024. For VAC, we utilized wall suction device devised by our center applying the technique of negative pressure wound therapy(NPWT). And we adjusted the tapering pressure of the abdominal wound wall vacuum which fixed to a 8Fr or 12Fr suction catheter and connected to the pressure regulator between -50 and -100 mmHg according to the wound exudation amount. When the amount of the wound exudation were less than 100 ml, the wall vacuum suction catheter could be connected to the negative pressure balloon so that the patients could be able to get out of bed. The wall vacuum of VAC was removed when the pancreatic fistula had sufficiently healed which resulting in complete wound healing.Results A total of 60 patients underwent OPD or LAPD. Among them, 9 had occured clinically related pancreatic fistulaI(CR-POPF)according to International Study Group on Pancreatic Fistula grade (POPF; 30%). one of the 3 grade C patients underwent Re-laparotomy due to the completely separated pancreaticojejunostomy and postoperative hemorrhage. 5 of the 6 grade B patients was performed tapering pressure of wall vacuum-assisted closure therapy for pancreatic juice exudation from the wound, and all of these patients had good outcomes by this VAC therapy.Conclusion Tapering pressure of wall VAC therapy could be a safe and effective treatment in the management of POPF ensuing wound exudation following open or Laparoscopic-assisted pancreatoduodenectomy. And this therapy may potentially reduce POPF-associated mortality.
C1 [Liu, Guo-Hua; Li, Ming-Yi] Jinan Univ, Inst Surg, Guangzhou, Guangdong, Peoples R China.
   [Liu, Guo-Hua; Xu, Zhen-Yue; Tan, Jian-Hui; Li, Jia-xing; Xu, Jun-Er; Tan, Xiao-Yu; Zhai, Jing-Wei; Wu, Jia-yuan; Zhong, Guo-Hui; Li, Ming-Yi] Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang, Guangdong, Peoples R China.
C3 Jinan University; Guangdong Medical University
RP Li, MY (通讯作者)，Jinan Univ, Inst Surg, Guangzhou, Guangdong, Peoples R China.; Li, MY (通讯作者)，Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang, Guangdong, Peoples R China.
EM limingyi63@163.com
FU Guangdong Medical University Clinical Research Program
FX We acknowledge Nian-Ping Chen, Chen Ming, Zhang Yi, and Xiao-Lu Liang,
   who contributed to the study by making substantial contributions to the
   acquisition of the data. All of them are involved in drafting the
   manuscript but do not meet the criteria for authorship.
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NR 24
TC 0
Z9 0
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-875X
J9 FRONT SURG
JI Front. Surg.
PD JUL 10
PY 2025
VL 12
AR 1612420
DI 10.3389/fsurg.2025.1612420
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 5EX7C
UT WOS:001534059100001
PM 40709063
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ren, L
   Zhang, C
   Zhao, L
   Li, C
   Zhang, L
   Xue, X
AF Ren, L.
   Zhang, C.
   Zhao, L.
   Li, C.
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SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
CR Ren LQ, 2021, INT WOUND J, V18, P787, DOI 10.1111/iwj.13582
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70649
DI 10.1111/iwj.70649
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0024
UT WOS:001623104100001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI Effective negative pressure wound therapy for open wounds: The
   importance of consistent pressure delivery
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE animal study; bioengineering laboratory research of chronic wounds;
   diabetic foot ulcer; finite element modelling; pressure ulcer; injury
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; SINGLE-USE; MIGRATION;
   COLLAGEN; BURDEN
AB Two distinct design concepts exist for single-use negative pressure wound therapy systems: Canister-based versus canisterless. The canister-based technology provides intrinsic stable delivery of the intended negative pressure, because exudate is constantly transferred from the wound into a canister, thereby preventing dressing saturation. In contrast, with a canisterless system, where delivery of the negative pressure depends on continuous evaporation of wound fluids from its dressing, loss of the intended wound-bed pressure may occur due to dressing saturation. To investigate whether these two designs differ in their mechanobiological effect with respect to magnitudes and distributions of tissue strain fields under the absorptive dressing, termed the influence zone, we integrated computational modelling with an animal study. This influence zone must be of biologically influential strain levels and extend sufficiently into the peri-wound for stimulating fibroblasts to migrate and progress the healing. We found that an effective influence zone requires continuous delivery of the intended pressure to the wound-bed. Loss of negative pressure at the wound-bed below 40 mmHg adversely lowered the peri-wound stimulation around a 120 x 70 mm sized wound to less than one-third of the baseline stimulation, and further pressure decreases to 20 mmHg or lower resulted in complete lack of peri-wound mechano-stimulation.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, Herbert J Berman Chair Vasc Bioengn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU Molnlycke Health Care; Israeli Ministry of Science Technology [3-17421];
   European Union [811965]
FX Molnlycke Health Care; Israeli Ministry of Science & Technology,
   Grant/Award Number: 3-17421; European Union's Horizon 2020 research and
   innovation programme, Grant/Award Number: 811965
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NR 57
TC 14
Z9 14
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD FEB
PY 2023
VL 20
IS 2
BP 328
EP 344
DI 10.1111/iwj.13879
EA JUL 2022
PG 17
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 8K9TL
UT WOS:000822976900001
PM 35818745
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Yang, SL
   Han, R
   Liu, Y
   Hu, LY
   Li, XL
   Zhu, LY
AF Yang, Shao-Ling
   Han, Rui
   Liu, Yu
   Hu, Li-Ye
   Li, Xiao-Ling
   Zhu, Lv-Yun
TI Negative pressure wound therapy is associated with up-regulation of bFGF
   and ERK1/2 in human diabetic foot wounds
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID FIBROBLAST-GROWTH-FACTOR; VACUUM-ASSISTED CLOSURE; PROLIFERATION;
   MULTICENTER; IMPAIRMENT; MECHANISMS; CELLS
AB Chronic foot wounds are a leading cause of morbidity and hospitalization for patients with diabetes. Negative pressure wound therapy (NPWT) is known to promote healing of diabetic foot wounds, but the underlying molecular mechanisms remain elusive. We propose to gain molecular insights into the wound healing promoting signals underlying the effects of NPWT on diabetic foot wounds in humans. We assessed 30 patients with diabetic foot ulcers. Of these cases, 15 were treated with NPWT, while 15 patients were treated with traditional gauze therapy. Granulated tissue was harvested before and after treatment in both patient groups and histologically analyzed with hematoxylin & eosin as well as Masson's trichrome staining methods. Immunohistochemistry and Western blot analysis was performed to evaluate expression of basic fibroblast growth factor (bFGF) and extracellular signal-regulated kinase (ERK) 1/2, previously associated with promoting cellular growth and/or wound healing. Unlike controls, the wounds in the NPWT-treated diabetic patients developed characteristic features of granulated tissue with increased collagen deposition. Immunohistochemical analysis also revealed an increase in bFGF levels in NPWT-treated patients. Western blot analysis further showed a significant up-regulation of bFGF and phosphorylated ERK1/2 protein levels in the NPWT-treated diabetic patients vs. controls. Our studies reveal that NPWT is associated with an up-regulation of bFGF and ERK1/2 signaling, which may be involved in promoting the NPWT-mediated wound healing response.
C1 [Yang, Shao-Ling; Hu, Li-Ye; Li, Xiao-Ling; Zhu, Lv-Yun] PLA, Peace Hosp, Dept Endocrinol, Shijiazhuang 050082, Hebei, Peoples R China.
   [Han, Rui] Hebei Med Univ, Dept Neurol, Affiliated Hosp 1, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yu] Hebei Med Univ, Dept Biochem & Mol Biol, Tradit Chinese Med Coll, Lab Med Biotechnol Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Zhu, LY (通讯作者)，PLA, Peace Hosp, Dept Endocrinol, 398 Zhongshan Rd, Shijiazhuang 050082, Hebei, Peoples R China.
EM yshling9@126.com
RI ; lvyun, zhu/Z-4736-2019
OI Liu, Yu/0000-0001-6268-3511; 
FU Hebei Province Natural Science Foundation of P.R. China [C2009001352]
FX This research was supported by the Hebei Province Natural Science
   Foundation of P.R. China (No. C2009001352). The authors wish to thank
   Professor Chun-Fang Zhao (Department of Embryology, Hebei Medical
   University) for her technical assistance.
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NR 37
TC 36
Z9 42
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JUL-AUG
PY 2014
VL 22
IS 4
BP 548
EP 554
DI 10.1111/wrr.12195
PG 7
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA AM2DG
UT WOS:000339658700017
PM 24809625
DA 2026-07-24
ER

PT J
AU Stanley, BJ
   Pitt, KA
   Weder, CD
   Fritz, MC
   Hauptman, JG
   Steficek, BA
AF Stanley, Bryden J.
   Pitt, Kathryn A.
   Weder, Christian D.
   Fritz, Michele C.
   Hauptman, Joe G.
   Steficek, Barbara A.
TI Effects of Negative Pressure Wound Therapy on Healing of Free
   Full-Thickness Skin Grafts in Dogs
SO VETERINARY SURGERY
LA English
DT Article
ID VACUUM-ASSISTED-CLOSURE; MICROVASCULAR BLOOD-FLOW; POLYURETHANE-FOAM;
   CONTROLLED-TRIAL; MANAGEMENT; DRESSINGS; DEVICE; GAUZE; OSTEOMYELITIS;
   TRANSDUCTION
AB Objective To compare healing of free, full-thickness, meshed skin grafts under negative pressure wound therapy (NPWT) with bolster dressings in dogs. Study design Randomized, controlled experimental study, paired design. Animals Dogs (n=5) Methods Full-thickness skin wounds (4cmx1.5cm) were created bilaterally on the antebrachia of 5 dogs (n=10). Excised skin was grafted to the contralateral limb. Grafts were randomized to NPWT or bolster dressings (control; CON). NPWT was applied continuously for 7 days. Grafts were evaluated on Days 2, 4, 7, 10, 14, and 17, biopsied on days 0, 4, 7, and 14, and had microbial culture on Day 7. Outcome variables were: time to first appearance of granulation tissue, percent graft necrosis, and percent open mesh. Significance was set at P<.05. Histologic findings, culture results, and graft appearance were reported. Results Granulation tissue appeared earlier in the NPWT grafts compared with CON grafts. Percent graft necrosis and remaining open mesh area were both greater in CON grafts compared with NPWT grafts at most time points. Histologic results showed no significant difference in all variables measured, and all cultures were negative. Conclusions Variables of graft acceptance were superior when NPWT was used in the first week post-grafting. Fibroplasia was enhanced, open meshes closed more rapidly and less graft necrosis occurred with NPWT application. More preclinical studies are required to evaluate histologic differences.
C1 [Stanley, Bryden J.; Pitt, Kathryn A.; Weder, Christian D.; Fritz, Michele C.; Hauptman, Joe G.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
   [Steficek, Barbara A.] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat, E Lansing, MI 48824 USA.
C3 Michigan State University; Michigan State University
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
OI Fritz, Michele/0000-0002-4146-2469
FU Michigan Animal Health Foundation; Michigan Veterinary Medical
   Association; NIH [5T35RR017491-07]
FX Contract grant sponsor: Michigan Animal Health Foundation, Michigan
   Veterinary Medical Association; Contract grant sponsor: NIH; Contract
   grant number: 5T35RR017491-07.
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NR 61
TC 52
Z9 61
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD JUN
PY 2013
VL 42
IS 5
BP 511
EP 522
DI 10.1111/j.1532-950X.2013.12005.x
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 238DA
UT WOS:000325919700003
PM 23550662
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Mitchell, SJ
   Jeyapalina, S
   Nichols, FR
   Agarwal, J
   Bachus, KN
AF Mitchell, Saranne J.
   Jeyapalina, Sujee
   Nichols, Francesca R.
   Agarwal, Jayant
   Bachus, Kent N.
TI Negative pressure wound therapy limits downgrowth in percutaneous
   devices
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SKIN-IMPLANT INTERFACE; TRANSFEMORAL
   AMPUTATION; STEM-CELLS; IN-VITRO; TITANIUM; TISSUE; MODEL; ATTACHMENT;
   PROSTHESES
AB Maintenance of a soft tissue seal around percutaneous devices is challenged by the downgrowth of periprosthetic tissuesa gateway to potential infection. As negative pressure wound therapy (NPWT) is used clinically to facilitate healing of complex soft tissue pathologies, it was hypothesized that NPWT could limit downgrowth of periprosthetic tissues. To test this hypothesis, 20 hairless guinea pigs were randomly assigned into four groups (n=5/group). Using a One-Stage (Groups 1 and 3) or a Two-Stage (Groups 2 and 4) surgical procedure, each animal was implanted with a titanium-alloy subdermal device porous-coated with commercially pure, medical grade titanium. Each subdermal device had a smooth titanium-alloy percutaneous post. The One-Stage procedure encompassed insertion of a fully assembled device during a single surgery. The Two-Stage procedure involved the implantation of a subdermal device during the first surgery, and then three weeks later, insertion of a percutaneous post. Groups 1 and 2 served as untreated controls and Groups 3 and 4 received NPWT. Four weeks postimplantation of the post, the devices and surrounding tissues were harvested, and histologically evaluated for downgrowth. Within the untreated control groups, the Two-Stage surgical procedure significantly decreased downgrowth (p=0.027) when compared with the One-Stage procedure. Independent of the surgical procedures performed, NPWT significantly limited downgrowth (p0.05) when compared with the untreated controls.
C1 [Mitchell, Saranne J.; Jeyapalina, Sujee; Nichols, Francesca R.; Bachus, Kent N.] Univ Utah, Dept Orthopaed, Orthopaed Res Lab, Salt Lake City, UT USA.
   [Mitchell, Saranne J.; Jeyapalina, Sujee; Nichols, Francesca R.; Bachus, Kent N.] George E Wahlen Dept Vet Affairs Med Ctr, Res Serv, Orthopaed Res Lab, Salt Lake City, UT USA.
   [Mitchell, Saranne J.; Jeyapalina, Sujee; Bachus, Kent N.] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
   [Agarwal, Jayant] Univ Utah, Sch Med, Dept Surg, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; US Department of
   Veterans Affairs; Utah System of Higher Education; University of Utah;
   Utah System of Higher Education; University of Utah
RP Bachus, KN (通讯作者)，Univ Utah, Orthopaed Res Lab, Orthopaed Ctr, 590 Wakara Way,Suite A100, Salt Lake City, UT 84108 USA.
EM kent.bachus@hsc.utah.edu
RI ; Bachus, Kent/KYO-7869-2024
OI Mitchell, Saranne J/0000-0002-6473-7648; 
FU US Army Medical Research Materiel Command [W81XWH-11-1-0435]; United
   States Department of Veterans Affairs Rehabilitation Research and
   Development Service [I01RX001217]; Department of Orthopaedics,
   University of Utah, Salt Lake City, Utah; US Army Medical Research
   Acquisition Activity (Fort Detrick, MD, USA)
FX Funding support was cumulatively provided from the US Army Medical
   Research Materiel Command (Award #W81XWH-11-1-0435), the United States
   Department of Veterans Affairs Rehabilitation Research and Development
   Service (Award #I01RX001217), and the Department of Orthopaedics,
   University of Utah, Salt Lake City, Utah. While the US Army Medical
   Research Acquisition Activity (Fort Detrick, MD, USA) awarded and
   administering acquisition office, the content of this research does not
   necessarily reflect the position or the policy of the Government, and no
   official endorsement should be inferred.
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NR 40
TC 12
Z9 16
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD JAN-FEB
PY 2016
VL 24
IS 1
BP 35
EP 44
DI 10.1111/wrr.12373
PG 10
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA DH6TT
UT WOS:000372925500004
PM 26487170
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU [Anonymous]
AF [Anonymous]
TI Guidelines regarding negative wound therapy (NPWT) in the diabetic foot
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; LOWER-EXTREMITY;
   SUBATMOSPHERIC PRESSURE; TISSUE EXPANSION; PREVALENCE; AMPUTATION;
   MULTICENTER; ULCERATION; STANDARDS
AB The purpose of these guidelines is to the summarize consensus of a multidisciplinary expert advisory panel convened to determine appropiriate use of negative pressure wound therapy (NPWT), also known as Vacuum-Assisted Closure(R) or V.A.C.(R) Therapy, in the treatment of diabetic foot wounds. The Tucson Expert Consensus Conference (TECC) on V.A.C. Therapy was convened in an effort to guide the direction for future research either to confirm or refute current consensus while providing practical guidance to the clinician currently treating diabetic foot wounds. The consensus committee discussed and commented on the following ten key questions regarding NPWT 1) How long should NPWT be used in the treatment of a diabetic foot wound? 2) Should NPWT be applied to a wound that has not been debrided? 3) How should the patient using NPWT be evaluated on an outpatient basis? 4) When should NPWT be applied following lower-extremity bypass? 5) When should NPWT be applied after incision and drainage of infection? 6) How should NPWT be used in patients with osteomyelitis? 7) How should nonadherence (i.e., noncompliance) be defined in the patient on NPWT? When should NPWT be discontinued in this population? 8) How should NPWT be used in combination with other modalities? 9) Should small, superficial, noninfected wounds be considered for NPWT? 10) How should we define success in future studies of NPWT?.
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NR 64
TC 36
Z9 49
U1 0
U2 3
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2004
SU B
BP 3S
EP 27S
PG 25
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 819MZ
UT WOS:000221320300001
PM 15311482
DA 2026-07-24
ER

PT J
AU Malmsjö, M
   Ingemansson, R
   Martin, R
   Huddleston, E
AF Malmsjo, Malin
   Ingemansson, Richard
   Martin, Robin
   Huddleston, Elizabeth
TI Negative-pressure wound therapy using gauze or open-cell polyurethane
   foam: Similar early effects on pressure transduction and tissue
   contraction in an experimental porcine wound model
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; STRESS; STATE; VEGF
AB Negative-pressure wound therapy (NPWT), also known as topical negative-pressure therapy, is widely used to manage wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane foam, but increasing interest has been directed toward delivering NPWT via gauze. In the present study, the early effects of NPWT on pressure transduction and wound contraction were examined in wounds filled with either polyurethane foam or gauze. An experimental setup of a porcine wound model was used, in which the animals were anesthetized for 12-14 hours. Negative pressures between -50 and -175 mmHg were applied in -25 mmHg increments. Wound bed pressure was measured using a saline filled catheter sutured to the bottom of the wound. The contraction of the wound edges was also determined. The recordings were performed upon reaching steady state, which typically occurred within 1 minute. For both fillers, wound bed negative pressure increased linearly with delivered vacuum with little deviation from set pressure ( correlation coefficient 0.99 in both cases). Similar tissue contraction was observed when using foam and gauze. The most prominent contraction was observed in the range of 0 to -50 mmHg with greater vacuum only producing minor further movement of the wound edge. In conclusion, the present experimental study shows that gauze and foam are equally effective at delivering negative pressure and creating mechanical deformation of the wound.
C1 [Malmsjo, Malin] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Martin, Robin; Huddleston, Elizabeth] Smith & Nephew Med Ltd, Kingston Upon Hull, N Humberside, England.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Smith & Nephew
RP Malmsjö, M (通讯作者)，Vasc Res, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
OI Ingemansson, Richard/0000-0001-7623-8953; Martin,
   Robin/0000-0002-9314-0437; Maljö, Malin/0000-0001-9849-9599
FU Ake Wiberg Foundation; M. Bergvall Foundation; Anna-Lisa and Sven Erik
   Lundgrens Foundation; Smith & Nephew Medical Limited
FX This study was supported by the Ake Wiberg Foundation, the M. Bergvall
   Foundation, the Anna-Lisa and Sven Erik Lundgrens Foundation, and Smith
   & Nephew Medical Limited. The authors would like to thank Gary Smith,
   Neill Bannister, and Martin Richardson for technical input into the
   study.
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NR 22
TC 85
Z9 98
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2009
VL 17
IS 2
BP 200
EP 205
DI 10.1111/j.1524-475X.2009.00461.x
PG 6
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 418ZJ
UT WOS:000264188600008
PM 19320888
DA 2026-07-24
ER

PT J
AU Collinsworth, AW
   Griffin, LP
AF Collinsworth, Ashley W.
   Griffin, Leah P.
TI The Effect of Timing of Instillation Therapy on Outcomes and Costs for
   Patients Receiving Negative Pressure Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE negative pressure wound therapy with instillation and dwell time; wound
   cleansing; wound treatment
ID VACUUM-ASSISTED CLOSURE; CARE; STANDARD; HEALTH; IMPACT; TRIAL
AB Introduction. Although NPWTi-d has been associated with improved patient outcomes compared with NPWT alone, questions remain regarding the timing of NPWTi-d initiation. Objective. This study examined the effect of the timing of NPWTi-d initiation on patient outcomes and costs. Methods. A retrospective analysis was conducted utilizing a national, all-payer hospital database and included patients who received NPWTi-d in 2019. A matched cohort of 514 patients who received either early (within 1 day of NPWT application) or late (within 2-7 days of NPWT application) NPWTi-d initiation was created using propensity scoring. Differences in clinical outcomes and costs were compared using Wilcoxon rank sum, chi-square, and t tests. Results. Early NPWTi-d initiation was associated with significantly shorter NPWT duration (7.0 vs. 11.4 days; P <.0001) and inpatient stay (13.4 vs. 16.3 days; P <.0001) compared with late NPWTi-d initiation. Early NPWTi-d initiation was also associated with fewer debridements, OR visits during hospitalization, days until final OR procedure, and wound-related readmissions. Patients with early NPWTi-d initiation had a $10 877 lower mean cost of index admission (P <.0001), which included lower NPWT costs. Conclusion. Study data suggest that in these patients with wounds, early NPWTi-d initiation helped improve patient outcomes and reduced care costs
C1 [Collinsworth, Ashley W.; Griffin, Leah P.] 3M, St Paul, MN USA.
   [Collinsworth, Ashley W.] 12930 W Interstate 10, San Antonio, TX 78249 USA.
C3 3M
RP Collinsworth, AW (通讯作者)，12930 W Interstate 10, San Antonio, TX 78249 USA.
EM acollinsworth@mmm.com
CR Anchalia Manjulata, 2020, Wounds, V32, pE84
   [Anonymous], 2020, PREM HEALTHC DAT DAT
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NR 24
TC 11
Z9 11
U1 0
U2 1
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2022
VL 34
IS 11
BP 269
EP +
DI 10.25270/wnds/22013
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 9X6BA
UT WOS:000949851700005
PM 36322918
DA 2026-07-24
ER

PT J
AU Pitt, KA
   Stanley, BJ
AF Pitt, Kathryn A.
   Stanley, Bryden J.
TI Negative Pressure Wound Therapy: Experience in 45 Dogs
SO VETERINARY SURGERY
LA English
DT Article
DE wound dressing; negative pressure; vacuum-assisted; wound healing
ID VACUUM-ASSISTED-CLOSURE; LOWER-EXTREMITY TRAUMA; SECURING SKIN-GRAFTS;
   OPEN CELL FOAM; OPERATION IRAQI-FREEDOM; SUBATMOSPHERIC PRESSURE;
   POLYURETHANE-FOAM; SWINE MODEL; WAR WOUNDS; MANAGEMENT
AB ObjectiveTo report experience with negative pressure wound therapy (NPWT) in 45 consecutive dogs admitted with extensive cutaneous wounds and to determine if NPWT is feasible in veterinary hospital practice.
   Study DesignProspective descriptive study.
   AnimalsDogs (n=45).
   MethodsCollected data were organized into 6 categories: patient data, wound data, NPWT data, adjunctive treatments, complications, and final outcome.
   ResultsWounds (53 in 45 dogs) were largely traumatic in origin, and distributed fairly evenly to the trunk, proximal and distal aspects of the limbs. Most wounds (34 dogs, 76%) had no granulation tissue and were treated a mean of 4.2 days after wounding, whereas 11 dogs had granulating wounds that were initially treated a mean of 87 days after wounding. Median NPWT use was 3 days with a mean hospitalization of 7.8 days. Most wounds (33; 62%) were closed surgically after NPWT and were healed by 14 days. The other 18 wounds healed (mean, 21 days) by second intention after hospital discharge. Overall, 96% of the wounds healed; 2 dogs died before definitive closure could be attempted.
   ConclusionNPWT is applicable to a wide variety of canine wounds, is well tolerated, allows for several days between dressing changes, and can used to optimize the wound bed for surgical closure or second intention healing.
C1 [Pitt, Kathryn A.; Stanley, Bryden J.] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
C3 Michigan State University
RP Stanley, BJ (通讯作者)，Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA.
EM stanle32@cvm.msu.edu
FU NIH HHS [T32 OD011167] Funding Source: Medline
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NR 64
TC 33
Z9 40
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0161-3499
EI 1532-950X
J9 VET SURG
JI Vet. Surg.
PD MAY
PY 2014
VL 43
IS 4
BP 380
EP 387
DI 10.1111/j.1532-950X.2014.12155.x
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA AH2TA
UT WOS:000335972800002
PM 24512302
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Zhang, WJ
   Wu, Y
   Pan, C
   Zhang, XY
   Yan, H
   Zhang, L
AF Zhang, Wenjing
   Wu, Yang
   Pan, Cheng
   Zhang, Xiangyun
   Yan, Hong
   Zhang, Li
TI Ruptured giant omphalocele with congenital short small intestine: a case
   report
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE omphalocele; congenital short small intestine; vacuum-sealing drainage;
   nutrition; perioperative management
ID SHORT-BOWEL SYNDROME; MANAGEMENT; GASTROSCHISIS; CHILDREN
AB We herein present a case of a ruptured giant omphalocele with congenital short small intestine. Vacuum-sealing drainage and carboxymethylcellulose silver dressing promoted wound healing after repair, avoided abdominal compartment syndrome, and reduced the risks of multiple procedures. We review the perioperative management of omphaloceles in congenital short small intestines.
C1 [Zhang, Wenjing; Zhang, Li] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.
   [Zhang, Wenjing; Zhang, Li] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.
   [Wu, Yang] Sichuan Univ, West China Hosp, Dept Pediat Surg, Chengdu, Peoples R China.
   [Pan, Cheng; Zhang, Xiangyun; Yan, Hong] Sichuan Univ, West China Univ Hosp 2, Dept Plast Aesthet Reparat & Reconstruct Surg, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University
RP Zhang, L (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.; Zhang, L (通讯作者)，Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.
EM zhanglihk@126.com
FU Science and Technology Bureau of Sichuan Province [2022YFS0044]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the grants from the Science and Technology Bureau of
   Sichuan Province (2022YFS0044).
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NR 34
TC 0
Z9 0
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 18
PY 2024
VL 11
AR 1421033
DI 10.3389/fnut.2024.1421033
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A3D1Y
UT WOS:001281359800001
PM 39091686
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Kim, PJ
   Fernandez, L
   Obst, MA
   Chaffin, A
   Faust, E
   Lantis, J
   Couch, K
   Desvigne, M
   Suski, M
   Kundu, N
   Mathews, M
   Simman, R
   Murphy, C
   Nierenberg, NE
   Téot, L
AF Kim, Paul J.
   Fernandez, Luis
   Obst, Mary Ann
   Chaffin, Abigail
   Faust, Elizabeth
   Lantis, John
   Couch, Kara
   Desvigne, Michael
   Suski, Mark
   Kundu, Neilendu
   Mathews, Marc
   Simman, Richard
   Murphy, Christine
   Nierenberg, Natalie E.
   Teot, Luc
TI Multidisciplinary Expert Consensus Statements and Recommendations for
   Use of Hypochlorous Acid as a Solution for Negative Pressure Wound
   Therapy With Instillation
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
DE antiseptic; bacteria; hypochlorous acid; negative pressure wound therapy
   with instillation and dwell time; NPWTi-d; wound
ID VACUUM-ASSISTED CLOSURE; MECHANISMS; STANDARD; OUTCOMES; CARE
AB Background. HOCl (eg, pHAp) preserved solutions have antimicrobial properties and are considered safe and effective for wound management. NPWTi-d (or NPWTi) is an established adjunctive wound modality for a variety of wound etiologies in various anatomic locations in which an instillate solution dwells on the surface of the wound to assist in wound bed preparation. A variety of solutions have been used, including 0.9% normal saline wound cleansers and antiseptics. pHAp is growing in popularity as the solution of choice for NPWTi-d. Objective. To evaluate consensus statements on the use of NPWTi-d with pHAp. Methods. A 15 -member multidisciplinary panel of expert clinicians in the United States, Canada, and France convened in person in April 2023 in Washington, D.C. and/or corresponded later to discuss 10 statements on the use of pHAp with NPWTi-d. The panelists then replied "agree" or "disagree" to each statement and had the option to provide comments. Results. Ten consensus statements are presented, along with the proportion of agreement or disagreement and summary comments. Although agreement with the statements on NPWTi-d with pHAp varied, the statements appear to reflect individual preferences for use rather than concerns about safety or efficacy. Conclusion. The consensus indicates that NPWTi-d with pHAp can have a beneficial effect in wound care.
C1 [Kim, Paul J.] Univ Texas Southwestern, Dept Plast Surg, Dept Orthoped Surg, Dallas, TX 75390 USA.
   [Fernandez, Luis] Univ Texas Hlth Sci Ctr Tyler, Dept Surg, Div Trauma Surg Surg Crit Care, Trauma Surg, Tyler, TX USA.
   [Obst, Mary Ann] Reg Hosp, Dept Surg, St Paul, MN USA.
   [Chaffin, Abigail] Tulane Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, New Orleans, LA USA.
   [Faust, Elizabeth] Reading Hosp, Dept Plast Surg Wound Care, W Reading, PA USA.
   [Lantis, John] Icahn Sch Med Mt Sinai West, New York, NY USA.
   [Couch, Kara] George Washington Univ Hosp, Washington, DC USA.
   [Desvigne, Michael] Abrazo Arrowhead Hosp, Glendale, AZ USA.
   [Suski, Mark] Los Robles Reg Med Ctr, Ctr Adv Wound Healing, Thousand Oaks, CA USA.
   [Kundu, Neilendu] Mercy Hlth, Dept Plast Reconstruct Surg, Cincinnati, OH USA.
   [Mathews, Marc] Univ Arizona, Dept Surg, Tucson, AZ USA.
   [Simman, Richard] Univ Toledo, Coll Med & Life Sci, Div Plast Surg, Toledo, OH USA.
   [Murphy, Christine] Ottawa Hosp, Limb Preservat Ctr, Ottawa, ON, Canada.
   [Nierenberg, Natalie E.] Tufts Univ, Sch Med, Dept Geog Med & Infect Dis, Boston, MA USA.
   [Teot, Luc] Montpellier Univ Hosp, Dept Plast Surg, Montpellier, France.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas-Health Sciences
   Center at Tyler (UTHSCT); Tulane University; Mount Sinai West; Icahn
   School of Medicine at Mount Sinai; George Washington University;
   University of Arizona; University System of Ohio; University of Toledo;
   University of Ottawa; Ottawa Hospital Research Institute; Tufts
   University; Universite de Montpellier; CHU de Montpellier
RP Kim, PJ (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Dept Orthoped Surg, Dallas, TX 75390 USA.
EM Paul.Kim@UTSouthwestern.edu
RI Oceja, Luis/B-5599-2011
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NR 45
TC 1
Z9 2
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2024
VL 36
IS 4
BP 108
EP 114
DI 10.25270/wnds/23143
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA SU7T7
UT WOS:001237033200003
PM 38743855
DA 2026-07-24
ER

PT J
AU Sumpio, B
   Thakor, P
   Mahler, D
   Blume, P
AF Sumpio, Bauer
   Thakor, Pratapji
   Mahler, David
   Blume, Peter
TI Negative Pressure Wound Therapy as Postoperative Dressing in Below Knee
   Amputation Stump Closure of Patients With Chronic Venous Insufficiency
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; MECHANISMS; INJURIES; TRAUMA
AB The role of negative pressure wound therapy (NPWT) in below knee amputation (BKA) stump closure is not well described. The purpose of this series was to analyze morbidity outcomes, particularly related to dehiscence, of BKAs treated with postoperative NPWT prior to definitive closure. Methods. Medical records were retrospectively reviewed from six patients with large diameter legs due to chronic venous insufficiency of Charcot disease, who underwent a BKA and received postoperative NPWT between April 2006 and December 2008. NPWT was applied as a postsurgical dressing over closed fascia to help condition the open stump for successful closure. Mean patient age was 56 years. The average hospital stay after BKA was 10 days (range, 6-15 days). Average duration of NPWT was 7 days (range, 4-9 days). Results. All patients survived to discharge. Complete reepithelialization and healing of the stump averaged 84 days (range, 39-182 days) following initial placement of NPWT. Patients were casted for prosthesis in an average of 90 days (range, 42-187 days). The average follow-up time was 311 days (range, 210-440 days). None of the wounds dehisced or required repeat procedures during follow up. Complete wound closure was achieved in all cases, and no local or systemic complications were recorded for any of the patients. Conclusion. This experience suggests that early, short-term application of NPWT may be a valuable adjunct in BKA stump closure.
C1 [Sumpio, Bauer] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA.
   [Thakor, Pratapji] Affiliated Foot & Ankle Surg, New Haven, CT USA.
   [Blume, Peter] Yale Univ, Sch Med, Sect Podiatr Surg, New Haven, CT USA.
C3 Yale University; Yale University
RP Sumpio, B (通讯作者)，Yale Univ, Sch Med, Dept Surg, POB 208062, New Haven, CT 06520 USA.
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NR 30
TC 8
Z9 8
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2011
VL 23
IS 10
BP 301
EP 308
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 838NN
UT WOS:000296299400003
PM 25881107
DA 2026-07-24
ER

PT J
AU McNulty, AK
   Wilkes, RP
   Marchand, B
   Ingram, S
   Mann, S
   Sieracki, J
AF McNulty, Amy K.
   Wilkes, Robert P.
   Marchand, Brenda
   Ingram, Shannon
   Mann, Samantha
   Sieracki, James
TI Finite element and preclinical analysis of tissue response to negative
   pressure wound therapy with a felted foam containing 10 mm through holes
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE vacuum assisted closure (VAC); debridement; finite element analysis;
   negative pressure wound therapy with instillation; strain; friction;
   non-viable tissue
ID BED PREPARATION; INSTILLATION; MANAGEMENT
AB Introduction Not all wound patients are candidates for surgical debridement. A felted, reticulated open cell foam with an array of 10 mm holes (VFCC) for use with instillation therapy has been used to eliminate non-viable tissue from patient wound beds. The mechanisms for this have not been fully elucidated. The current study elaborates the biomechanical stresses, strains and work imparted to tissue with VFCC versus commonly used reticulated open cell foam (ROCF) dressings.Methods Finite element analysis (FEA) measured strain and deformation occurring at the tissue interface with VFCC or ROCF. FEA results were compared to those in a preclinical, porcine sloughy wound model.Results The peak maximum principal strain imparted to tissue at -125 mmHg with VFCC was 27.8% versus 0.9% with ROCF. The frictional work around the holes in the VFCC was 0.179 mJ while negligible with ROCF.Discussion The FEA model predicted high strains at the sides of the macrodomes of tissue pulled into the through holes and was consistent with slough removal in the preclinical study. Frictional work around the 10mmholes in the VFCC may pin the tissue leading to higher strain energy densities as tissue is pulled into the holes allowing for fracturing and removal of devitalized tissue.
C1 [McNulty, Amy K.; Wilkes, Robert P.; Marchand, Brenda; Ingram, Shannon; Mann, Samantha; Sieracki, James] Solventum, St Paul, MN 55144 USA.
RP McNulty, AK (通讯作者)，Solventum, St Paul, MN 55144 USA.
EM akmcnulty@solventum.com
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
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   Zeybek B, 2017, BIOMECH MODEL MECHAN, V16, P1819, DOI 10.1007/s10237-017-0921-7
NR 39
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD AUG 21
PY 2025
VL 13
AR 1568540
DI 10.3389/fbioe.2025.1568540
PG 11
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 6VE8G
UT WOS:001562800300001
PM 40918443
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Nordmeyer, M
   Pauser, J
   Biber, R
   Jantsch, J
   Lehrl, S
   Kopschina, C
   Rapke, C
   Bail, HJ
   Forst, R
   Brem, MH
AF Nordmeyer, Matthias
   Pauser, Johannes
   Biber, Roland
   Jantsch, Jonathan
   Lehrl, Siegfried
   Kopschina, Carsten
   Rapke, Christian
   Bail, Hermann J.
   Forst, Raimund
   Brem, Matthias H.
TI Negative pressure wound therapy for seroma prevention and surgical
   incision treatment in spinal fracture care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE NPWT; Spinal fracture; Wound complication; Wound healing
ID VACUUM-ASSISTED CLOSURE; MANAGEMENT; TRAUMA; DEFECT; BONE
AB To evaluate the clinical use and economic aspects of negative pressure wound therapy (NPWT) after dorsal stabilisation of spinal fractures. This study is a prospective randomised evaluation of NPWT in patients with large surgical wounds after surgical stabilisation of spinal fractures by internal fixation. Patients were randomised to either standard wound dressing treatment (group A) or NPWT (group B). The wound area was examined by ultrasound to measure seroma volumes in both groups on the 5th and 10th day after surgery. Furthermore, data on economic aspects such as nursing time for wound care and material used for wound dressing were evaluated. A total of 20 patients (10 in each group) were enrolled. Throughout the whole study, mean seroma volume was significantly higher in group A than that in group B (day 5: 1<bold></bold>9 ml versus 0 ml; P = 0<bold></bold>0007; day 10: 1<bold></bold>6 ml versus 0<bold></bold>5 ml; P <0<bold></bold>024). Furthermore, patients of group A required more wound care time (group A: 31 +/- 10 minutes; group B 13<bold></bold>8 +/- 6 minutes; P = 0<bold></bold>0005) and more number of compresses (total number; group A 35 +/- 15; group B 11 +/- 3; P = 0<bold></bold>0376). NPWT reduced the development of postoperative seroma, reduced nursing time and reduced material required for wound care.
C1 [Nordmeyer, Matthias; Pauser, Johannes; Biber, Roland; Kopschina, Carsten; Rapke, Christian; Bail, Hermann J.; Brem, Matthias H.] Klinikum Nuremberg, Dept Trauma & Orthopaed Surg, Nurnberg, Germany.
   [Pauser, Johannes] Univ Erlangen Nurnberg, Div Orthoped Rheumatol, Erlangen, Germany.
   [Jantsch, Jonathan] Univ Regensburg, Inst Med Microbiol & Hyg, Regensburg, Germany.
   [Lehrl, Siegfried] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany.
   [Forst, Raimund] Univ Hosp Erlangen, Dept Orthopaed Surg, Erlangen, Germany.
   [Brem, Matthias H.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Div Trauma Surg, Dept Surg,Fac Med, Erlangen, Germany.
   Friedrich Alexander Univ Erlangen Nuernberg, Erlangen, Germany.
C3 Klinikum Nurnberg; University of Erlangen Nuremberg; University of
   Regensburg; University of Erlangen Nuremberg; University of Erlangen
   Nuremberg; University of Erlangen Nuremberg; University of Erlangen
   Nuremberg
RP Brem, MH (通讯作者)，Klinikum Nurnberg, Dept Orthopaed & Trauma Surg, Breslauer Str 201, D-90471 Nurnberg, Germany.
EM matthiasbrem@hotmail.de
RI Jantsch, Jonathan/KEE-9741-2024; Biber, Roland/AAP-6691-2021
OI Biber, Roland/0000-0002-7700-0311
CR Altintas B, 2015, INT WOUND J, V12, P662, DOI 10.1111/iwj.12198
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   Loos B, 2006, ZBL CHIR, V131, pS124, DOI 10.1055/s-2006-921425
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   Stannard JP, 2006, J TRAUMA, V60, P1301, DOI 10.1097/01.ta.0000195996.73186.2e
   Stannard JP, 2010, INJURY, V41, P780, DOI 10.1016/j.injury.2009.08.011
   Stannard JP, 2009, J ORTHOP TRAUMA, V23, P552, DOI 10.1097/BOT.0b013e3181a2e2b6
   Stannard JR, 2009, OSTOMY WOUND MANAG, V55, P58
   VERNER EF, 1985, MED CLIN N AM, V69, P375
   Wilkes RP, 2012, SURG INNOV, V19, P67, DOI 10.1177/1553350611414920
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NR 25
TC 43
Z9 49
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2016
VL 13
IS 6
BP 1176
EP 1179
DI 10.1111/iwj.12436
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8TQ
UT WOS:000387664400012
PM 25932993
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Verbelen, J
   Hoeksema, H
   Heyneman, A
   Pirayesh, A
   Monstrey, S
AF Verbelen, Jozef
   Hoeksema, Henk
   Heyneman, Alexander
   Pirayesh, Ali
   Monstrey, Stan
TI Treatment of Fournier's Gangrene With a Novel Negative Pressure Wound
   Therapy System
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; EXPERIENCE; MANAGEMENT
AB Fournier's gangrene (FG) is a complex condition that requires surgical debridement, hemodynamic support, antibiotics, and appropriate wound management. This study is the first to assess the use of a low-vacuum negative pressure wound therapy (LV-NPWT) system with low-adherent contact surface in two cases of FG. Methods. The protocol-of-care included twice weekly dressing changes and irrigation with a povidone-iodine-water mixture. Assessments included wound progression (% granulation tissue), ratings of dressing ingrowth, pain during treatment and at dressing changes, patient comfort, and ease-of-use. Results. A 51-year-old man (Patient A) developed FG after surgical removal of a perianal abscess. He received 16 days of LV-NPWT with five dressing changes. A 64-year-old man (Patient B) with multiple comorbidities, developed FG after traumatic injury. He received 20 days of LV-NPWT with six dressing changes. In both patients, LV-NPWT promoted rapid granulation tissue formation. Pain scores averaged low-to-moderate during treatment and dressing changes, and tissue ingrowth was minimal. Conclusion. Overall, ratings were favorable for LV-NPWT ease-of-use and patient comfort. Despite the complexity of these wounds, with the use of LV-NPWT, both wounds progressed to a point where they were able to successfully receive surgical closure with skin grafts and/or flaps. These cases may suggest that LV-NPWT may have a potential role in complex wound management.
C1 [Verbelen, Jozef; Hoeksema, Henk; Heyneman, Alexander; Pirayesh, Ali; Monstrey, Stan] Ghent Univ Hosp, Dept Plast Surg, Wound Healing & Tissue Engn Unit, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Monstrey, S (通讯作者)，Ghent Univ Hosp, Dept Plast Surg, Wound Healing & Tissue Engn Unit, De Pintelaan 185, B-9000 Ghent, Belgium.
EM Stan.monstrey@ugent.be
OI Hoeksema, Henik/0000-0003-3160-4539
FU ConvaTec, Inc.
FX The Department of Plastic and Reconstructive Surgery Wound Healing and
   Tissue Engineering Unit, Gent University Hospital, Gent, Belgium,
   received an unrestricted research grant from ConvaTec, Inc. ConvaTec was
   not involved in the collection or analysis of data. ConvaTec provided
   products for the study.
CR [Anonymous], FOURNIER GANGRENE
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NR 17
TC 8
Z9 9
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2011
VL 23
IS 11
BP 342
EP 349
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 855BL
UT WOS:000297538400005
PM 25881197
DA 2026-07-24
ER

PT J
AU Kilpadi, DV
   Cunningham, MR
AF Kilpadi, Deepak V.
   Cunningham, Mark R.
TI Evaluation of closed incision management with negative pressure wound
   therapy (CIM): Hematoma/seroma and involvement of the lymphatic system
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SURGICAL INCISIONS
AB The objective of this porcine study was to evaluate the effect of closed incision management with negative pressure wound therapy (CIM) on hematoma/seroma formation, fluid removal into the CIM canister, and involvement of the lymphatic system. In each swine (n = 8), two sets of ventral contralateral subcutaneous dead spaces with overlying sutured incisions were created. Stable isotope-labeled nanospheres were introduced into each subcutaneous dead space. Each contralateral incision was assigned to CIM (continuous -125 mmHg negative pressure) and control (semipermeable film dressing), respectively. Following 4 days of therapy, hematoma/seroma was weighed, total fluid volume in canisters was measured, five pre-identified lymph nodes were harvested, and five key organs were biopsied. There was 25 +/- 8 g (standard error [SE]) (63%) less hematoma/seroma in CIM sites compared to control sites (p = 0.002), without any fluid collection in the CIM canister. In lymph nodes, there were similar to 60 mu g (similar to 50%) more 30- and 50-nm nanospheres from CIM sites than from control sites (p = 0.04 and 0.05, respectively). There was significantly greater nanosphere incidence from CIM sites than from control sites in lungs, liver, and spleen (p < 0.05); no nanospheres were detected in kidney biopsies. Thus, in this porcine model, application of CIM significantly decreased hematoma/seroma levels without fluid collection in the canister, which may be explained by increased lymph clearance.
C1 [Kilpadi, Deepak V.] KCI, San Antonio, TX USA.
   [Cunningham, Mark R.] Surpass Inc, Osceola, WI USA.
RP Kilpadi, DV (通讯作者)，6203 Farinon Dr, San Antonio, TX 78249 USA.
EM kilpadid@kci1.com
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NR 23
TC 157
Z9 179
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD SEP-OCT
PY 2011
VL 19
IS 5
BP 588
EP 596
DI 10.1111/j.1524-475X.2011.00714.x
PG 9
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 823AA
UT WOS:000295091700009
PM 22092797
DA 2026-07-24
ER

PT J
AU Dalmedico, MM
   Fedalto, AD
   Martins, WA
   de Carvalho, CKL
   Fernandes, BL
   Ioshii, SO
AF Dalmedico, Michel Marcos
   Fedalto, Angela do Rocio
   Martins, Waleska Alves
   de Carvalho, Chayane Karla Lucena
   Fernandes, Beatriz Luci
   Ioshii, Sergio Ossamu
TI Effectiveness of Negative Pressure Wound Therapy in Treating Diabetic
   Foot Ulcers: A Systematic Review and Meta-Analysis of Randomized
   Controlled Trials
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; MULTICENTER; EFFICACY; SAFETY
AB Background. Diabetic foot ulcers (DFUs) present devastating complications. Management of these wounds includes applying a vacuum device composed of a fenestrated tube embedded in a foam dressing and connected to a vacuum pump to collect the fluid in a vessel. Objective. To review the effectiveness of negative pressure wound therapy (NPWT) in treating DFUs and evaluate the clinical outcomes of full and partial wound healing. Methods. A systematic review and meta-analysis of randomized controlled trials was conducted after searching the PubMed, Web of Science, and Cochrane Library databases. Studies that described the use of NPWT in the management of DFUs were included and compared with different interventions for the proposed outcomes. Results. A total of 14 studies were included, 1 of which was later excluded during internal validation. Wound healing outcomes were analyzed in 2 studies, showing the superiority of total wound healing in the NPWT group. Ten studies compared the effect of different interventions on wound area reduction and 8 of these results were best with NPWT. Three studies showed clinical and statistical homogeneity (I-2 = 100%), making it possible to conduct a meta-analysis. Conclusion. Although the articles included in this systematic review have limitations regarding methodological quality and clinical heterogeneity, the results showed the potential benefit of NPWT in healing and wound area reduction. These outcomes are essential in the prevention of amputation in patients with DFU.
C1 [Dalmedico, Michel Marcos; de Carvalho, Chayane Karla Lucena; Fernandes, Beatriz Luci; Ioshii, Sergio Ossamu] Pontificia Univ Catolica Parana, Grad Program Hlth Technol, Curitiba, Brazil.
   [Fedalto, Angela do Rocio; Martins, Waleska Alves] Univ Posit, Nursing Dept, Curitiba, Brazil.
C3 Pontificia Universidade Catolica do Parana
RP Fernandes, BL (通讯作者)，Pontificia Univ Catolica Parana, Polytech Sch, Grad Program Hlth Technol, R Imaculada Conceicao 1155, BR-80320030 Curitiba, PR, Brazil.
EM beatriz.fernandes@pucpr.br
RI IOSHII, SERGIO OSSAMU/K-7490-2014; Fernandes, Beatriz/JGL-9245-2023
OI IOSHII, SERGIO OSSAMU/0000-0002-7871-4463; 
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NR 27
TC 13
Z9 16
U1 0
U2 4
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD AUG
PY 2024
VL 36
IS 8
BP 281
EP 289
DI 10.25270/wnds/23140
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA G0G5R
UT WOS:001313503500006
PM 39241769
DA 2026-07-24
ER

PT J
AU Rother, U
   Theune, M
   Lang, W
   Meyer, A
AF Rother, Ulrich
   Theune, Mona
   Lang, Werner
   Meyer, Alexander
TI Pilot assessment of the effect of negative pressure wound therapy on
   microperfusion of chronic and acute wounds
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Negative pressure therapy; microperfusion; CLTI; fasciotomy; O2C
ID VACUUM-ASSISTED CLOSURE; MICROVASCULAR BLOOD-FLOW; LASER-DOPPLER; TISSUE
   OXYGENATION; PERFUSION; WALL
AB BACKGROUND: Negative pressure wound therapy (NPWT) has been established over years for treatment of chronic and complex wounds.
   OBJECTIVE: Aim of this study was to investigate the effect NPWT on the microperfusion.
   METHODS: Prospective single centre analysis of patients treated with NPWT due to acute (ACUTE) wounds after fasciotomy or patients with chronic wounds (CHRONIC) due to a chronic limb threatening ischemia was performed. NPWT was conducted through a three days sequence with a negative pressure of -120 mmHg. Before after and during the entire period of therapy the microperfusion was assessed (O2C (TM), LEA Medizintechnik).
   RESULTS: Comparison of the perfusion values of 28 patients (CHRONIC/ACUTE 5/23, women/men 8/20) before and after the NPWT sequence showed a non-significant improvement in the CHRONIC group (supine position: p = 0.144, elevated position p = 0.068) and a significant decrease in the ACUTE group (supine position p = 0.012, elevated position p = 0.034). This effect could also been demonstrated during the NPWT over time (CHRONIC: supine position: p =0 .320 , elevated position: p = 0.053, ACUTE: supine position: p = 0.021, elevated position: p = 0.012).
   CONCLUSION: Microperfusion measurements showed alterations and differences in wound bed perfusion of acute and chronic wounds; acute wounds tended to a decrease of blood flow, whereas this effect was not seen in chronic wounds in peripheral artery disease.
C1 [Rother, Ulrich; Theune, Mona; Lang, Werner; Meyer, Alexander] Friedrich Alexander Univ Erlangen Nuremberg, Dept Vasc Surg, Erlangen, Germany.
C3 University of Erlangen Nuremberg
RP Rother, U (通讯作者)，Friedrich Alexander Univ Erlangen Nuremberg, Krankenhausstr 12, D-91054 Erlangen, Germany.
EM ulrich.rother@uk-erlangen.de
RI Rother, Ulrich/LGZ-9441-2024
CR Almeida JE, 2018, J WOUND CARE, V27, pS28, DOI 10.12968/jowc.2018.27.Sup2.S28
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NR 28
TC 1
Z9 3
U1 0
U2 2
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2021
VL 79
IS 3
BP 455
EP 462
DI 10.3233/CH-211189
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA XU5JY
UT WOS:000734302100009
PM 34057141
DA 2026-07-24
ER

PT J
AU Warner, HJ
   Wagner, WD
AF Warner, Harleigh J.
   Wagner, William D.
TI Fabrication of biodegradable foams for deep tissue negative pressure
   treatments
SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
LA English
DT Article
DE polyester; polycaprolactone; poly(lactic-co-glycolic acid); foams;
   negative pressure wound therapy
ID VACUUM-ASSISTED CLOSURE; DRUG-DELIVERY; WOUND CONTROL; DEGRADATION;
   INJURY
AB Devices for negative pressure wound therapy (NPWT) rely on compressible foams operating at the tissue-device interface. Clinically used foams are nonabsorbable and if used on deep wounds or left in place for an extended period of time, excessive cell ingrowth and formation of granulation tissue into the foam may require a surgical procedure to remove the foam. Foams with fast degradation and with low immunogenicity and fibrotic response are required. Foams composed of combinations of poly(lactide-co-glycolide) (PLGA), poly(lactide-co-caprolactone) (PLCL), and polycaprolactone (PCL) were created by combined salt leaching and solvent displacement protocols. In vitro and in vivo degradation studies and mechanical properties of foams were evaluated and compared to clinically used poly(vinyl alcohol) (PVA) foam and PCL foams. Foams composed of PLGA (50:50 lactide:glycolide) of low molecular weight blended with PCL maintained mechanical properties and degraded significantly after 21 days of subcutaneous implantation in rats. The most ideal formulations for use in NPWT were identified as copolymeric PLGA (M-n 3000 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at either a 75:25 or 50:50 ratio, and copolymeric PLGA (M-n 7500 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at a 50:50 ratio. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1998-2007, 2018.
C1 [Warner, Harleigh J.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.
   [Warner, Harleigh J.; Wagner, William D.] Wake Forest Univ, Bowman Gray Sch Med, Dept Biomed Engn, Winston Salem, NC 27109 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.; Wagner, WD (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Biomed Engn, Winston Salem, NC 27109 USA.
EM wwagner@wakehealth.edu
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 23
TC 4
Z9 5
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4973
EI 1552-4981
J9 J BIOMED MATER RES B
JI J. Biomed. Mater. Res. Part B
PD JUL
PY 2018
VL 106
IS 5
BP 1998
EP 2007
DI 10.1002/jbm.b.34007
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA GJ5SU
UT WOS:000435443500036
PM 29031009
DA 2026-07-24
ER

PT J
AU Leung, BK
   LaBarbera, LA
   Carroll, CA
   Allen, D
   McNulty, AK
AF Leung, Braden K.
   LaBarbera, Lori A.
   Carroll, Christopher A.
   Allen, Diwi
   McNulty, Amy K.
TI The Effects of Normal Saline Instillation in Conjunction With Negative
   Pressure Wound Therapy on Wound Healing in a Porcine Model
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; RANDOMIZED CONTROLLED-TRIAL; SUBATMOSPHERIC
   PRESSURE; DEVICE; MULTICENTER; SWINE
AB Acute and chronic wounds impact the lives of millions of patients Since its introduction, negative pressure wound therapy using reticulated open cell foam (NPWT/ROCF). has significantly improved the healing outcome for many of these wounds Methods The effects of intermittent instillation of normal saline in conjunction with NPWT were investigated to determine if instillation therapy provides additional benefits in wound healing Conventional NPWT/ROCF as delivered by VA C (R) Therapy was compared to VA C Instill (R) Therapy with normal saline in the treatment of porcine full-thickness excisional wounds Wounds were treated with NPWT/ROCF or NPWT/ROCF with instillation therapy at approximately 4 cycles of normal saline instillation per day and dwell times of either 5 or 60 minutes for the instilled saline on the wound bed Results Instillation therapy with normal saline at either dwell time elicited a faster rate of wound filling with granulation tissue that contained an increase in total collagen content compared to continuous NPWT/ROCF alone Analyses of wound contraction and the hydration state of the treated tissue exhibited no apparent differences between the experimental instillation therapy groups and the control NIDWT/ROCF group Conclusion. Collectively, these data suggest that instillation therapy with normal saline may lead to wound fill with higher quality granulation tissue composed of increased collagen following wounding of cutaneous tissue compared to the use of NPWT/ROCF alone
C1 [Leung, Braden K.] KCI, Global Res & Dev, San Antonio, TX 78249 USA.
RP Leung, BK (通讯作者)，KCI, Global Res & Dev, 6203 Fannon Dr, San Antonio, TX 78249 USA.
FU Kinetic Concepts, Inc (KCI)
FX Financial support for execution of this study was provided by Kinetic
   Concepts, Inc (KCI)
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NR 29
TC 24
Z9 30
U1 0
U2 8
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD JUL
PY 2010
VL 22
IS 7
BP 179
EP 187
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 629FJ
UT WOS:000280180100004
PM 25901498
DA 2026-07-24
ER

PT J
AU Orlov, A
   Gefen, A
AF Orlov, Aleksei
   Gefen, Amit
TI The potential of a canister-based single-use negative-pressure wound
   therapy system delivering a greater and continuous absolute pressure
   level to facilitate better surgical wound care
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE animal study; bioengineering laboratory research; closed incision;
   finite element modelling; lateral tension sutures
ID VACUUM-ASSISTED CLOSURE; EVIDENCE-BASED RECOMMENDATIONS; TISSUE LOADS;
   INCISION; MANAGEMENT; INFECTION; DEVICE; SURGERY; STEPS
AB Two types of single-use negative-pressure wound therapy systems are currently available to treat surgical wounds: Canister-based and canisterless. This work was aimed to evaluate the performance of a canister-based vs a canisterless system, each with a different negative-pressure setting and technology for fluid management. Continuous delivery of a specified level of negative pressure to the wound bed is hypothesised to be important for promoting surgical wound healing, by achieving continuous reduction of lateral tension in the wound, particularly through decrease of skin stress concentrations around suture insertion sites. To test the above hypothesis, we developed a computational modelling framework, a laboratory bench-test for simulated clinical use and had further conducted a pre-clinical study in a porcine model for closed incision. We specifically focussed on the impact of effective fluid management for continuous delivery of a stable, consistent negative pressure and the consequences of potential losses of the pressure level over the therapy period. We found that a greater (absolute) negative-pressure level and its continuous, consistent delivery through controlled fluid management technology, by removing excess fluid from the dressing, provides far superior biomechanical performances. These conditions are more likely to result in better quality of the repaired tissues.
C1 [Orlov, Aleksei; Gefen, Amit] Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
C3 Tel Aviv University
RP Gefen, A (通讯作者)，Tel Aviv Univ, Fac Engn, Dept Biomed Engn, IL-6997801 Tel Aviv, Israel.
EM gefen@tauex.tau.ac.il
RI Gefen, Amit/M-4720-2015
OI Gefen, Amit/0000-0002-0223-7218
FU H2020 Marie Sklodowska-Curie Actions [811965]; project STINTS (Skin
   Tissue Integrity under Shear); Ministry of Science, Technology and Space
   [3-17421]; Molnlycke Health Care (Gothenburg, Sweden)
FX H2020 Marie Sklodowska-Curie Actions, Grant/Award Number: 811965;
   project STINTS (Skin Tissue Integrity under Shear); Ministry of Science,
   Technology and Space, Grant/Award Number: Medical Devices Program Grant
   no. 3-17421; Molnlycke Health Care (Gothenburg, Sweden)
CR [Anonymous], 3D IMAGE SEGMENTATIO
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NR 63
TC 10
Z9 11
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2022
VL 19
IS 6
BP 1471
EP 1493
DI 10.1111/iwj.13744
EA JAN 2022
PG 23
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 4T2LH
UT WOS:000745720900001
PM 35048527
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Lessing, C
   Slack, P
   Hong, KZ
   Kilpadi, D
   McNulty, A
AF Lessing, Chris
   Slack, Paul
   Hong, K. Z.
   Kilpadi, Deepak
   McNulty, Amy
TI Negative Pressure Wound Therapy With Controlled Saline Instillation
   (NPWTi): Dressing Properties and Granulation Response In Vivo
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FIBROBLASTS
AB Negative pressure wound therapy (NPWT) with reticulated open-cell foam (ROCF) dressings (ROCF G, V.A.C.(R) GranuFoam (TM) Dressing, KCI USA, Inc, San Antonio, TX) creates a healing environment that removes wound exudates, reduces edema, and promotes perfusion and granulation tissue formation. Controlled instillation of saline during NPWT (NPWTi) may further enhance healing by facilitating automatic and contained volumetric wound irrigation and cleansing. A new ROCF dressing (ROCF-V, V.A.C. VeraFlo (TM) Dressing, KCI USA, Inc, San Antonio, TX) has been developed for use with NPWTi; benchtop and in vivo tests compared the properties and performance of both ROCF-G and ROCF-V. Pore size and density (contributors to microdeformation) are similar for both ROCF-G and ROCF-V, while mechanical testing demonstrates ROCF-V is stronger than ROCF-G under both tensile and tear loading. ROCF-V surface energy is higher than ROCF-G, making ROCF-V less hydrophobic. Under wet conditions ROCF-V wicks more fluid and shows less pressure drop than ROCF-G, suggesting ROCF-V may be better suited for NPWTi. After 7 days of therapy in a porcine full-thickness excisional wound model, NPWTi with ROCF-V resulted in a 43% increase (P < 0.05) in granulation tissue thickness compared to NPWT with ROCF-G. These data suggest NPWTi with ROCF-V creates a wound healing environment that provides enhanced granulation tissue formation compared to standard NPWT with ROCF-G.
C1 [Lessing, Chris; Slack, Paul; Hong, K. Z.; Kilpadi, Deepak; McNulty, Amy] Kinet Concepts Inc, San Antonio, TX 78249 USA.
RP Lessing, C (通讯作者)，Kinet Concepts Inc, 6203 Farinon Dr, San Antonio, TX 78249 USA.
EM chris.lessing@kci1.com
OI Lessing, Chris/0009-0001-5009-6624
FU KCI USA, Inc.
FX This study was financially supported by KCI USA, Inc. All of the authors
   are employed by KCI USA, Inc.
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NR 22
TC 44
Z9 52
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD OCT
PY 2011
VL 23
IS 10
BP 309
EP 319
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 838NN
UT WOS:000296299400004
PM 25881108
DA 2026-07-24
ER

PT J
AU Frykberg, RG
   Williams, DV
AF Frykberg, Robert G.
   Williams, David V.
TI Negative-pressure wound therapy and diabetic foot amputations - A
   retrospective study of payer claims data
SO JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION
LA English
DT Article; Proceedings Paper
CT 11th Annual International Meeting of the
   International-Society-of-Pharmacoeconomics-and-Outcomes-Research
CY MAY 20-24, 2006
CL Philadelphia, PA
SP Int Soc Pharmacoecon & Outcomes Res
ID LOWER-EXTREMITY AMPUTATION; VACUUM-ASSISTED CLOSURE; LOWER-LIMB
   AMPUTATION; HEALTH-CARE; FOLLOW-UP; ULCERS; POPULATION; PREVENTION;
   COST; ULCERATION
AB Background: This study was undertaken to assess the benefits of negative-pressure wound therapy (NPWT) versus traditional wound therapies in reducing the incidence of lower-extremity amputations in patients with diabetic fool: ulcers.
   Methods: Administrative claims data for patients with diabetic foot ulcers from commercial payers (n = 3,524) and Medicare (n = 12,795) were retrospectively analyzed. Patients were divided into NPWT and control/traditional therapy groups on the basis of administrative codes. Risk-adjustment procedures were then performed to match patient risk categories (through total treatment costs) and wound severities (through debridement depth).
   Results: The incidence of amputations in the NPWT groups was lower than that in the control groups. For the cost-based risk-adjustment analysis, amputation incidences with NPWT versus traditional therapy were 35% lower in the Medicare sample (10.8% versus 16.6%; P = .0077) and 34% lower in the commercial payer sample (14.1 % versus 21.4%; P = .0951). Whereas overall amputation rates increased progressively with increasing wound debridement depth in both control groups, the same increasing trend did not occur in the NPWT groups.
   Conclusions: Patients with diabetic foot ulcers in the Medicare sample treated with NPWT had a lower incidence of amputations than those undergoing traditional wound therapy; this finding was evident in wounds of varying depth in both populations studied.
C1 Carl T Hayden Vet Adm Med Ctr, Podiatry Sect, Phoenix, AZ 85012 USA.
   Milliman Inc, Windsor, CT USA.
RP Frykberg, RG (通讯作者)，Carl T Hayden Vet Adm Med Ctr, Podiatry Sect, 650 E Indian Sch Rd, Phoenix, AZ 85012 USA.
CR Andros G, 2006, OSTOMY WOUND MANAG, P1
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NR 40
TC 26
Z9 30
U1 0
U2 13
PU AMER PODIATRIC MED ASSOC
PI BETHESDA
PA 9312 OLD GEORGETOWN ROAD, BETHESDA, MD 20814-1621 USA
SN 8750-7315
EI 1930-8264
J9 J AM PODIAT MED ASSN
JI J. Am. Podiatr. Med. Assoc.
PD SEP-OCT
PY 2007
VL 97
IS 5
BP 351
EP 359
DI 10.7547/0970351
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics
GA 219KD
UT WOS:000250082600001
PM 17901338
DA 2026-07-24
ER

PT J
AU Bollero, D
   Degano, K
   Gangemi, EN
   Aloj, D
   Malvasio, V
   Stella, M
AF Bollero, Daniele
   Degano, Kiran
   Gangemi, Ezio N.
   Aloj, Domenico
   Malvasio, Valeria
   Stella, Maurizio
TI Long-term follow-up of negative pressure wound therapy with
   instillation: a limb salvage procedure?
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Amputation; Instillation; Limb salvage; Negative pressure; Wound healing
ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; QUALITY-OF-LIFE;
   LOWER-EXTREMITY; AMPUTATION; RECONSTRUCTION; INFECTIONS; FRACTURES;
   OUTCOMES; BONE
AB Negative pressure wound therapy (NPWT) is a treatment to reduce oedema, stimulate granulation tissue formation, remove wound exudate and diminish wound area, thus preparing it for secondary healing, skin grafting or coverage with flaps. The association of instillation to NPWT (NPWTi) is a new method for treating severe wounds, in particular, limb lesions at high risk for amputation. This therapy helps to deliver instillation fluid automatically into the contaminated wound, before application of negative pressure. These steps, repeated cyclically, help to remove infectious material, leading to a better moist environment, a necessary condition for wound healing. We report our experience of treating three patients with complex wounds and associated noble structure exposition conservatively with NPWTi and flap coverage. In a long-term follow-up (5 years), we were able to achieve a stable surgery reconstruction on preserved limbs, without evidence of chronic infection and other sequelae or complications. Despite the fact that our experience is limited, as it is based on only a few cases, it suggests how NPWTi could be considered useful in a conservative approach to the treatment of acute complex wounds of the lower extremities. In these patients with high risk of amputation, a long-term follow-up becomes fundamental in order to evaluate wound bed status after NPTWi.
C1 [Bollero, Daniele; Degano, Kiran; Gangemi, Ezio N.; Malvasio, Valeria; Stella, Maurizio] CTO Hosp, AOU Citta Salute, Dept Gen & Specialist Surg, Div Plast & Reconstruct Surg,Burn Ctr, Via Zuretti 29, I-10126 Turin, Italy.
   [Aloj, Domenico] CTO Hosp, AOU Citta Salute, Dept Orthopaed Surg, Div Muscular Skeletal Traumatol, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; A.O.U. Citta della
   Salute e della Scienza di Torino
RP Bollero, D (通讯作者)，CTO Hosp, AOU Citta Salute, Dept Gen & Specialist Surg, Div Plast & Reconstruct Surg,Burn Ctr, Via Zuretti 29, I-10126 Turin, Italy.
EM info@danielebollero.it
RI Stella, Maurizio/JGD-2010-2023; Gangemi, Ezio Nicola/M-8754-2019
OI Gangemi, Ezio Nicola/0000-0003-4381-7443
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NR 26
TC 8
Z9 11
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2016
VL 13
IS 5
BP 768
EP 773
DI 10.1111/iwj.12373
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EB8UV
UT WOS:000387667600080
PM 25234266
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Kostaras, EK
   Tansarli, GS
   Falagas, ME
AF Kostaras, Efthymios K.
   Tansarli, Giannoula S.
   Falagas, Matthew E.
TI Use of Negative-Pressure Wound Therapy in Breast Tissues: Evaluation of
   the Literature
SO SURGICAL INFECTIONS
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; PYODERMA-GANGRENOSUM; RECONSTRUCTION;
   MANAGEMENT; SALVAGE; MULTICENTER; ULCERS; FLAP
AB Background: Negative-pressure wound therapy (NPWT) has been suggetsed to have a positive impact on the healing of sternal or extremity wounds. However, few data deriving from breast surgery have been published. We evaluated the available literature regarding the effectiveness of NPWT systems in the healing of breast tissues.
   Methods: The PubMed and Scopus databases were searched systematically, and all studies that provided relevant data were considered eligible for inclusion in the review. Twenty studies (154 female patients) met the inclusion criteria (four cohort studies, one case series, and 15 case reports).
   Results: The NPWT system was used alone in 17 patients and in combination with other techniques in the remaining 137. The lesion was secondary to plastic surgery in 107 women, other operations in 40 women (38 of them for breast cancer), and primary breast infection in seven women. Infections (including necrotizing fasciitis), pyoderma gangrenosum, and necrosis were among the most common complications for which NPWT was used. In total, 150 of 154 patients receiving NPWT healed completely. Two patients died before complete closure for reasons unrelated to the wound, and NPWT failed in two patients who healed later with muscle flap coverage.
   Conclusion: The scant published evidence suggests that NPWT systems might be useful in the healing of complicated breast wounds. However, larger studies are needed to investigate the effectiveness of this system further before it is established in breast surgery.
C1 [Kostaras, Efthymios K.; Tansarli, Giannoula S.; Falagas, Matthew E.] Alfa Inst Biomed Sci, Athens 15123, Greece.
   [Falagas, Matthew E.] IASO Gen Hosp, IASO Grp, Dept Internal Med Infect Dis, Athens, Greece.
   [Falagas, Matthew E.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
C3 Alfa Institute Of Biomedical Sciences; Tufts University
RP Falagas, ME (通讯作者)，Alfa Inst Biomed Sci, 9 Neapoleos St, Athens 15123, Greece.
EM m.falagas@aibs.gr
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NR 33
TC 18
Z9 20
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-2964
EI 1557-8674
J9 SURG INFECT
JI Surg. Infect.
PD DEC 1
PY 2014
VL 15
IS 6
BP 679
EP 685
DI 10.1089/sur.2013.165
PG 7
WC Infectious Diseases; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Surgery
GA AW5TA
UT WOS:000346335500003
PM 24871230
DA 2026-07-24
ER

PT J
AU Hermans, MHE
   Cutting, K
AF Hermans, M. H. E.
   Cutting, K.
TI NPWT or HRT-dressing? Results of an expert panel and a Delphi panel
   analysis
SO JOURNAL OF WOUND CARE
LA English
DT Article
DE hydration response technology; negative pressure wound therapy; wound
   bed preparation; MMP
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY; SUBATMOSPHERIC
   PRESSURE; BED PREPARATION
AB Objective: To investigate the similarities and differences between Hydration Response Technology (HRT) and negative pressure wound therapy (NPWT) with regard to wound bed preparation, and to devise a set of recommendations for their use on the basis of the opinion of two panels.
   Method: An expert panel that analysed in vitro and clinical data as well as the similarities and differences between the two modalities was established.This culminated in a series of recommendations on which modality to use for which indication.These recommendations were presented to a Delphi panel, consisting of users of both NPWT and HRT-dressing.The panel was then asked to produce its own recommendations.
   Results: The outcomes and recommendations of both panels were reported. NPWT is the preferred treatment modality for abdominal dehisced wounds, and to a lesser extent, for surgical wound healing by secondary intention. For all other indications, the treatment modalities are at least equal, with HRT-dressing often being the superior mode to treat wounds such as venous leg ulcers, arterial ulcers and vasculitis.
   Conclusion: In the opinion of the expert panel and the Delphi panel, both modalities share a number of clinical and non-clinical properties. However, because of the numerous advantages of HRT technology, HRT dressing has the potential to replace NPWT in a number of indications, where the patient, healthcare providers and institutions may benefit.
C1 [Hermans, M. H. E.] Hermans Consulting Inc, Newtown, PA USA.
   [Cutting, K.] Buckinghamshire New Univ, Uxbridge, Middx, England.
C3 Buckinghamshire New University
RP Hermans, MHE (通讯作者)，Hermans Consulting Inc, Newtown, PA USA.
EM mhermans2@comcast.net
RI Cutting, Keith/AAH-9434-2019
FU Sorbion GmbH & Co, Senden, Germany
FX This study was sponsored by Sorbion GmbH & Co, Senden, Germany. Authors
   M. Hermans and K. Cutting are consultants to Sorbion GmbH & Co,
   Senden,Germany.
CR AHCRQ, 2009, NEG PRESS WOUND THER
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   Wood Benjamin C, 2011, J Surg Orthop Adv, V20, P168
NR 52
TC 14
Z9 16
U1 0
U2 3
PU MA HEALTHCARE LTD
PI LONDON
PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND
SN 0969-0700
EI 2062-2916
J9 J WOUND CARE
JI J. Wound Care
PD NOV
PY 2013
VL 22
IS 11
BP 573
EP +
DI 10.12968/jowc.2013.22.11.573
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 253PV
UT WOS:000327102700002
PM 24225597
DA 2026-07-24
ER

PT J
AU Hasse, B
   Husmann, L
   Zinkernagel, A
   Weber, R
   Lachat, M
   Mayer, D
AF Hasse, Barbara
   Husmann, Lars
   Zinkernagel, Annelies
   Weber, Rainer
   Lachat, Mario
   Mayer, Dieter
TI Vascular graft infections
SO SWISS MEDICAL WEEKLY
LA English
DT Article
DE prosthetic vascular graft infection; negative pressure wound therapy;
   graft preservation; 18F-fluorodeoxyglucose positron emission tomography;
   computed tomographic angiography
ID VACUUM-ASSISTED CLOSURE; MUSCLE FLAP COVERAGE; ANTIMICROBIAL THERAPY;
   PROSTHESIS INFECTION; F-18-FDG PET/CT; DACRON GRAFTS; WOUND CLOSURE;
   MANAGEMENT; SURGERY; COMPLICATIONS
AB Vascular procedures are rarely complicated by infection, but if prosthetic vascular graft infection (PVGI) occurs, morbidity and mortality are high. Several patient-related, surgery-related and postoperative risk factors are reported, but they are not well validated. PVGI is due to bacterial colonisation of the wound and the underlying prosthetic graft, generally as a result of direct contamination during the operative procedure, mainly from the patient's skin or adjacent bowel. There is no consensus on diagnostic criteria or on the best management of PVGI. On the basis of reported clinical studies and our own experience, we advocate a surgical approach combining repeated radical local debridement, with graft preservation whenever possible or partial excision of the infected graft, depending on its condition, plus simultaneous negative-pressure wound therapy (NPWT). In addition, antimicrobial therapy is recommended, but there is no consensus on which classes of agent are adequate for the treatment of PVGI and whether certain infections may be treated by means of NPWT alone. Since staphylococci and Gram-negative rods are likely to be isolated, empirical treatment might include a penicillinase-resistant beta-lactam or a glycopeptide, plus an aminoglycoside, the latter for Gram-negative coverage and synergistic treatment of Gram-positive cocci. Additionally, empirical treatment might include rifampicin since it penetrates well into biofilms.
C1 [Hasse, Barbara; Zinkernagel, Annelies; Weber, Rainer] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, CH-8091 Zurich, Switzerland.
   [Hasse, Barbara; Husmann, Lars; Zinkernagel, Annelies; Weber, Rainer; Lachat, Mario; Mayer, Dieter] Univ Zurich, CH-8091 Zurich, Switzerland.
   [Husmann, Lars] Univ Zurich Hosp, Clin Nucl Med, CH-8091 Zurich, Switzerland.
   [Lachat, Mario; Mayer, Dieter] Univ Zurich Hosp, Cardiovasc Surg Clin, CH-8091 Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital
RP Hasse, B (通讯作者)，Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Raemistr 100, CH-8091 Zurich, Switzerland.
EM barbara.hasse@usz.ch; dieter.mayer@usz.ch
RI Lachat, Mario/G-4826-2011; Zinkernagel, Annelies/F-1780-2017; Weber,
   Rainer/D-5175-2012; Mayer, Dieter/E-7617-2011; Hasse,
   Barbara/T-1054-2017
OI Lachat, Mario/0000-0001-7812-2110; Zinkernagel,
   Annelies/0000-0003-4700-1118; Mayer, Dieter/0000-0001-5933-7749; Hasse,
   Barbara/0000-0001-7196-3734
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NR 51
TC 91
Z9 98
U1 0
U2 5
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD JAN 24
PY 2013
VL 143
AR w13754
DI 10.4414/smw.2013.13754
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 184QH
UT WOS:000321907400001
PM 23348860
OA Green Submitted, Green Accepted, gold
DA 2026-07-24
ER

PT J
AU Moris, V
   Cristofari, S
   See, LA
   Guillier, D
   Zwetyenga, N
   Pluvy, I
AF Moris, Vivien
   Cristofari, Sarra
   See, Leslie Ann
   Guillier, David
   Zwetyenga, Narcisse
   Pluvy, Isabelle
TI Randomized comparative study of negative pressure wound therapy versus
   compression dressing on split-thickness skin grafts of the lower limbs
   in an elderly population
SO EXPERT REVIEW OF MEDICAL DEVICES
LA English
DT Article
DE Skin graft; lower limbs; elderly population; NPWT therapy; compression
   dressing; graft necrosis
ID VACUUM-ASSISTED CLOSURE; CONVENTIONAL THERAPY; MANAGEMENT; OUTCOMES;
   TRIAL
AB IntroductionFailure to adequately secure the skin graft to the lower limbs recipient bed can result in loss of the graft. Our objective was to compare the healing of split-thickness skin grafts three weeks postoperatively, using either negative pressure wound therapy (NPWT) or conventional compression bandaging.MethodsIn this multicenter randomized controlled study, patients with tissue loss ranging from 50 cm2 to 600 cm2 on the lower limbs and treated with split-thickness skin grafts were included in three French hospitals. A digital photographic evaluation was performed at 3 weeks.ResultsDuring 9 years, 70 patients were included in the study and allocated to a treatment group. The grafted area was similar in both groups. Loss of graft was significantly reduced in the NPWT group with 14.6 cm2 compared to 29 cm2 in the control group (p = 0.0003). The hospital stay was also significantly reduced in the NPWT group, at 4 days versus 6.5 days in the control group (p = 0.0284). In the NPWT group, 60% reported pain compared to 22.9% in the control group (p = 0.0048).ConclusionsThe use of NPWT dressings improves skin graft take by reducing necrosis, improving the graft's adherence to the recipient site, and reducing hospital length-of-stay.
C1 [Moris, Vivien; See, Leslie Ann; Guillier, David] CHU Dijon, Serv Chirurg Maxillo Faciale Plast Reconstructrice, Chirurg Main, 14 Rue Paul Gaffarel, F-21000 Dijon, France.
   [Zwetyenga, Narcisse] Hop Tenon, Serv Chirurg Plast Reconstruct Esthet Microchirurg, Paris, France.
   [Cristofari, Sarra] Univ Bourgogne Franche Comte, Lipids Nutr Canc Team NuTox, UMR866, Dijon, France.
   [Pluvy, Isabelle] CHU Jean Minjoz, Serv Chirurg Orthoped Traumatol Plast Reconstructr, Besancon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; Assistance Publique
   Hopitaux Paris (APHP); Sorbonne Universite; Hopital Universitaire Tenon
   - APHP; Universite Bourgogne Europe; Institut Agro; Institut Agro Dijon;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Marie et Louis Pasteur; CHU Besancon
RP Moris, V (通讯作者)，CHU Dijon, Serv Chirurg Maxillo Faciale Plast Reconstructrice, Chirurg Main, 14 Rue Paul Gaffarel, F-21000 Dijon, France.
EM morisvivien@gmail.com
RI moris, vivien/MPJ-6556-2025
OI moris, vivien/0000-0001-5594-2394
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
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NR 31
TC 3
Z9 3
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-4440
EI 1745-2422
J9 EXPERT REV MED DEVIC
JI Expert Rev. Med. Devices
PD JUN 2
PY 2024
VL 21
IS 6
BP 519
EP 526
DI 10.1080/17434440.2024.2350494
EA MAY 2024
PG 8
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA UU6N6
UT WOS:001217316300001
PM 38712592
DA 2026-07-24
ER

PT J
AU Yane, Y
   Hida, J
   Chiba, Y
   Makutani, Y
   Ushijima, H
   Yoshioka, Y
   Iwamoto, M
   Wada, T
   Daito, K
   Tokoro, T
   Ueda, K
   Kawamura, J
AF Yane, Yoshinori
   Hida, Jin-ichi
   Chiba, Yasutaka
   Makutani, Yusuke
   Ushijima, Hokuto
   Yoshioka, Yasumasa
   Iwamoto, Masayoshi
   Wada, Toshiaki
   Daito, Koji
   Tokoro, Tadao
   Ueda, Kazuki
   Kawamura, Junichiro
TI Effectiveness of negative pressure wound therapy with instillation and
   dwelling after stoma closure: a retrospective and propensity score
   matching analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; LOOP ILEOSTOMY; SKIN
   CLOSURE; RISK-FACTORS; REVERSAL
AB The use of temporary diverting stoma has become more common in low colorectal anastomosis to reduce anastomotic complications. Surgical site infection (SSI) at the stoma closure site has been one of the most frequent postoperative complications. The aim of this study was to compare the short-term outcomes between conventional primary suture closure and negative pressure wound therapy with instillation and dwelling (NPWTi-d) therapy following purse-string suturing, using propensity score matching analysis. We retrospectively evaluated the medical records of 107 patients who underwent stoma closure between January 2016 and October 2020. The primary outcome was the proportion of SSI. The secondary outcome was the day of postoperative length of stay. Propensity score matching with one-to-one match was performed for reducing treatment selection bias. Of a total of 107 patients, 67 patients had been treated with conventional primary closure and 40 with NPWTi-d therapy. The propensity score matching derived 37 pairs. The respective SSI proportions were 0% and 16.2% in the groups with NPWTi-d and primary closure (P = 0.025). The respective median days of postoperative hospital stay were 9.0 and 10.0 in the groups with NPWTi-d and primary closure (P = 0.453). NPWTi-d therapy with purse-string suturing was effective in reducing SSI after stoma closure.
C1 [Yane, Yoshinori; Makutani, Yusuke; Ushijima, Hokuto; Yoshioka, Yasumasa; Iwamoto, Masayoshi; Wada, Toshiaki; Daito, Koji; Tokoro, Tadao; Ueda, Kazuki; Kawamura, Junichiro] Kindai Univ, Dept Surg, Fac Med, 377-2 Ohno Higashi, Osaka 5898511, Japan.
   [Hida, Jin-ichi] Kindai Univ, Dept Surg Gastroenterol, Nara Hosp, Nara, Japan.
   [Chiba, Yasutaka] Kindai Univ, Fac Med, Div Biostat, Clin Res Ctr, Osaka, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University); Kindai University (Kinki University)
RP Kawamura, J (通讯作者)，Kindai Univ, Dept Surg, Fac Med, 377-2 Ohno Higashi, Osaka 5898511, Japan.
EM kawamuraj@med.kindai.ac.jp
RI Kawamura, Junichiro/H-9205-2019; Ueda, Kazuki/AAB-6618-2022; 幕谷,
   悠介/IAP-9683-2023
OI Kawamura, Junichiro/0000-0001-5404-5317; 
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NR 34
TC 4
Z9 4
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 18
PY 2022
VL 12
IS 1
AR 916
DI 10.1038/s41598-022-05016-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YI8VH
UT WOS:000744120000079
PM 35042963
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Das Ghatak, P
   Schlanger, R
   Ganesh, K
   Lambert, L
   Gordillo, GM
   Martinsek, P
   Roy, S
AF Das Ghatak, Piya
   Schlanger, Richard
   Ganesh, Kasturi
   Lambert, Lynn
   Gordillo, Gayle M.
   Martinsek, Patsy
   Roy, Sashwati
TI A Wireless Electroceutical Dressing Lowers Cost of Negative Pressure
   Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; TRAUMA; TISSUE
AB Objective: To test whether the use of a wireless electroceutical dressing (WED) (Procellera (R)) in conjunction with a 5-day negative pressure wound therapy (NPWT) may reduce the number of dressing changes required per week with this therapy.
   Approach: At the Ohio State University Comprehensive Wound Center, chronic wound patients (n = 30) undergoing NPWT were randomized into two arms following consent as approved by the institutional review board. The control arm received standard of care NPWT, where the dressing change was performed thrice a week. The test arm received the same care except that the WED was added as an interface layer and dressing change was limited to twice a week.
   Results: A reduced cost of care was achieved using the WED in conjunction with NPWT. Despite fewer dressing changes in wounds dressed with the WED, closure outcomes were comparable with no overt signs of any wound complication, including infection. The cost of NPWT care during the week was significantly lower (from $2918 to $2346) in the WED-treated group compared with patients in the control arm.
   Innovation: This work introduces a novel technology platform involving a WED, which may be used in conjunction with NPWT. If used as such, NPWT is effective in decreasing the frequency of dressing change and lowering the cost of care.
   Conclusion: This work points toward the benefit of using the WED combined with NPWT. A larger clinical trial investigating the cost-effectiveness of WED in wound care is warranted.
C1 [Roy, Sashwati] Ohio State Univ, Dept Surg, Comprehens Wound Ctr, Wexner Med Ctr, Columbus, OH 43210 USA.
   Ohio State Univ, Dept Plast Surg, Comprehens Wound Ctr, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Roy, S (通讯作者)，Ohio State Univ, Dept Surg, Comprehens Wound Ctr, Wexner Med Ctr, 511 DHLRI, Columbus, OH 43210 USA.
EM sashwati.roy@osumc.edu
RI ; Gordillo, Gayle/LPP-8918-2024
OI Roy, Sashwati/0000-0002-9995-4917; Gordillo, Gayle/0000-0001-8369-6637
CR Abarca-Buis RF, 2014, ADV SKIN WOUND CARE, V27, P156, DOI 10.1097/01.ASW.0000444849.71374.bc
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NR 27
TC 22
Z9 30
U1 1
U2 24
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAY
PY 2015
VL 4
IS 5
BP 302
EP 311
DI 10.1089/wound.2014.0615
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CL8YI
UT WOS:000357260300004
PM 26005596
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Lin, H
   Chen, H
   Xu, Y
   Li, J
   Zhou, Q
   Ren, D
AF Lin, H.
   Chen, H.
   Xu, Y.
   Li, J.
   Zhou, Q.
   Ren, D.
TI VACUUM SEALING DRAINAGE TECHNOLOGY IN MANAGEMENT OF CAVITY WOUND CAUSED
   BY ANORECTAL DISEASE: A PRELIMINARY STUDY.
SO DISEASES OF THE COLON & RECTUM
LA English
DT Meeting Abstract
CT Annual Scientific Meeting of the
   American-Society-of-Colon-and-Rectal-Surgeons
CY JUN 10-14, 2017
CL Seattle, WA
SP Amer Soc Colon & Rectal Surg
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD JUN
PY 2017
VL 60
IS 6
MA P197
BP E241
EP E242
PG 2
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology; Surgery
GA EU6VG
UT WOS:000401172800298
DA 2026-07-24
ER

PT J
AU Song, JH
   Yu, AX
   Yu, GR
   He, XB
   Deng, K
   Tao, SX
   Pan, ZY
   Zhang, JH
AF Song, Jiuhong
   Yu, Aixi
   Yu, Guorong
   He, Xibin
   Deng, Kai
   Tao, Shengxiang
   Pan, Zhenyu
   Zhang, Jianhua
TI Tissue regeneration of severely infected bone exposure wound by
   combining vacuum sealing drainage with flap transplantation
SO TISSUE ENGINEERING
LA English
DT Meeting Abstract
CT 17th Interdisciplinary Research Conference on Biomaterials
CY APR 02-03, 2007
CL Oxford, ENGLAND
C1 VSD Med Technol CO Ltd, Wuhan, Peoples R China.
   Wuhan Univ, Zhongnam Hosp, Dept Microsurg, Wuhan 430072, Peoples R China.
C3 Wuhan University
RI pan, zhenyu/HKE-5511-2023
NR 0
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1076-3279
J9 TISSUE ENG
JI Tissue Eng.
PD JUN
PY 2007
VL 13
IS 6
BP 1387
EP 1387
PG 1
WC Cell & Tissue Engineering
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 178RK
UT WOS:000247237600080
DA 2026-07-24
ER

PT J
AU Wang, YF
   Wang, TT
   Zheng, XY
   Ma, CW
   Cao, MC
   He, XY
   Li, HX
   Li, ZY
   Wang, ZJ
   Jia, RF
AF Wang, Yafei
   Wang, Tingting
   Zheng, Xinying
   Ma, Chunwei
   Cao, Mingcong
   He, Xiaoyang
   Li, Haixia
   Li, Zhaoyang
   Wang, Zhijing
   Jia, Rufeng
TI Application of vacuum sealing drainage in perioperative patients with
   refractory wounds in orthopedics and prognostic analysis ☆
SO CURRENT PROBLEMS IN SURGERY
LA English
DT Article
ID THERAPY
C1 [Wang, Yafei; Zheng, Xinying; Jia, Rufeng] Cangzhou Cent Hosp, Dept Nursing, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
   [Wang, Tingting] Cangzhou Cent Hosp, Dept Neu Ropsychol Cognit Impairment, Cangzhou, Hebei, Peoples R China.
   [Ma, Chunwei; He, Xiaoyang; Li, Haixia] Yanshan Cty Peoples Hosp, Dept Surg, Yanshan, Hebei, Peoples R China.
   [Cao, Mingcong] Cangzhou Cent Hosp, Dept Ophthalmol, Cangzhou, Hebei, Peoples R China.
   [Li, Zhaoyang] Cangzhou Cent Hosp, Dept Gen Adm, Cangzhou, Hebei, Peoples R China.
   [Wang, Zhijing] Cangzhou Cent Hosp, Dept Anesthesiol, Cangzhou, Hebei, Peoples R China.
RP Jia, RF (通讯作者)，Cangzhou Cent Hosp, Dept Nursing, 16 Xinhua West Rd, Cangzhou 061001, Hebei, Peoples R China.
EM jiarfczch@163.com
RI /HRC-5468-2023
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-3840
EI 1535-6337
J9 CURR PROB SURG
JI Curr. Probl. Surg.
PD APR
PY 2026
VL 77
AR 101963
DI 10.1016/j.cpsurg.2025.101963
PG 13
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA ET5BW
UT WOS:001709361500001
PM 41942261
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Deng, CL
   Yao, YZ
   Liu, ZY
   Li, H
   Yang, ZW
   Wang, DL
   Wei, ZR
AF Deng, Chengliang
   Yao, Yuanzhen
   Liu, Zhiyuan
   Li, Hai
   Yang, Zhaowei
   Wang, Dali
   Wei, Zairong
TI Chronic wound treatment with high-density nanofat grafting combined with
   negative pressure wound therapy
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Adipose-derived stem cells; nanofat; negative pressure wound therapy;
   stromal vascular fraction; wound healing
ID MESENCHYMAL STEM-CELLS; ADIPOSE-TISSUE; FAT; DIFFERENTIATION;
   REGENERATION; GEL
AB Negative pressure wound therapy is an essential technological advancement in wound care and stem cell therapy is the most promising treatment for chronic wounds. Nanofat grafting, an adipose-derived stem cell-based cytotherapy, has shown therapeutic potential for various conditions. However, the effects of negative pressure wound therapy combined with nanofat grafting on wound healing have not been investigated. In this study, high-density nanofat grafting combined with negative pressure wound therapy was used to treat patients with chronic wounds, while negative pressure wound therapy alone was used as the control. Data were analyzed with independent sample t-tests. A comparative study of wound healing rates, post-surgery, and histological changes revealed that average wound healing rates in the high-density nanofat combined with negative pressure wound therapy group were 26.50% +/- 9.51%, compared to 12.02% +/- 4.20% in the negative pressure wound therapy alone group. There were statistically significant differences (P < 0.01). Histological analysis using hematoxylin and eosin and Masson's trichrome staining, along with CD31 immunohistochemistry, showed less lymphocyte infiltration, greater collagen accumulation, and newly formed vessel growth in the high-density nanofat combined with negative pressure wound therapy group, compared with the control group. High-density nanofat grafting combined with negative pressure wound therapy is a safe and effective option, enhancing chronic wound healing.
C1 [Deng, Chengliang; Yao, Yuanzhen; Liu, Zhiyuan; Li, Hai; Yang, Zhaowei; Wang, Dali; Wei, Zairong] Zunyi Med Coll, Dept Plast Surg, Affiliated Hosp, 149 Dalian Rd, Zunyi 563000, Guizhou, Peoples R China.
C3 Zunyi Medical University
RP Wang, DL; Wei, ZR (通讯作者)，Zunyi Med Coll, Dept Plast Surg, Affiliated Hosp, 149 Dalian Rd, Zunyi 563000, Guizhou, Peoples R China.
EM daliwangzy@sina.com; zairong-wei@163.com
RI Yang, Zhaowei/D-1903-2009
FU National Nature Science Foundation of China [81660323]
FX This work was supported by the National Nature Science Foundation of
   China (81660323).
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NR 31
TC 6
Z9 10
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 2
BP 1402
EP 1411
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HN2GB
UT WOS:000460002600009
DA 2026-07-24
ER

PT J
AU Xue, X
   Li, N
   Ren, L
AF Xue, X.
   Li, N.
   Ren, L.
TI 撤稿声明: Effect of Vacuum Sealing Drainage on Healing Time and
   Inflammation-Related Indicators in Patients With Soft Tissue Wounds
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Retraction
CR Xue X, 2021, INT WOUND J, V18, P639, DOI 10.1111/iwj.13565
NR 1
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD APR
PY 2025
VL 22
IS 4
AR e70650
DI 10.1111/iwj.70650
PG 1
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA F0101
UT WOS:001623111800001
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Aly, E
AF Aly, Emad
TI Peer review report 1 on "Effect of vacuum sealing drainage in
   dermatoplasty of large area of cutaneous defects"
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Editorial Material
C1 [Aly, Emad] Aberdeen Royal Infirm, Gen Surg, Aberdeen AB25 2ZN, Scotland.
C3 University of Aberdeen
RP Aly, E (通讯作者)，Aberdeen Royal Infirm, Gen Surg, Aberdeen AB25 2ZN, Scotland.
EM emad.aly@nhs.net
RI /H-6638-2019
NR 0
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JAN-DEC
PY 2017
VL 37
SU 1
BP S312
EP S312
DI 10.1016/j.ijsu.2017.05.009
PG 1
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA VH7VY
UT WOS:000455050200295
DA 2026-07-24
ER

PT J
AU Roberts, DJ
   Zygun, DA
   Grendar, J
   Ball, CG
   Robertson, HL
   Ouellet, JF
   Cheatham, ML
   Kirkpatrick, AW
AF Roberts, Derek J.
   Zygun, David A.
   Grendar, Jan
   Ball, Chad G.
   Robertson, Helen Lee
   Ouellet, Jean-Francois
   Cheatham, Michael L.
   Kirkpatrick, Andrew W.
TI Negative-pressure wound therapy for critically ill adults with open
   abdominal wounds: A systematic review
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Abdominal injuries; intra-abdominal sepsis; temporary abdominal closure;
   vacuum-assisted wound closure; wounds and injuries
ID VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; FASCIAL CLOSURE; COMPARTMENT
   SYNDROME; INTRAABDOMINAL HYPERTENSION; TEMPORARY CLOSURE;
   CLINICAL-TRIALS; VENTRAL HERNIA; TRAUMA; MANAGEMENT
AB BACKGROUND: Open abdominal management with negative-pressure wound therapy (NPWT) is increasingly used for critically ill trauma and surgery patients. We sought to determine the comparative efficacy and safety of NPWT versus alternate temporary abdominal closure (TAC) techniques in critically ill adults with open abdominal wounds.
   METHODS: We conducted a systematic review of published and unpublished comparative studies. We searched MEDLINE, PubMed, EMBASE, Scopus, Web of Science, the Cochrane Database, the Center for Reviews and Dissemination, clinical trials registries, and bibliographies of included articles. Two authors independently abstracted data on study design, methodological quality, patient characteristics, and outcomes.
   RESULTS: Among 2,715 citations identified, 2 randomized controlled trials and 9 cohort studies (3 prospective/6 retrospective) met inclusion criteria. Methodological quality of included prospective studies was moderate. One randomized controlled trial observed an improved fascial closure rate (relative risk [RR], 2.4; 95% confidence interval [CI], 1.0-5.3) and length of hospital stay after addition of retention sutured sequential fascial closure to the Kinetic Concepts Inc. (KCI) vacuum-assisted closure (VAC). Another reported a trend toward enhanced fascial closure using the KCI VAC versus Barker's vacuum pack (RR, 2.6; 95% CI, 0.95-7.1). A prospective cohort study observed improved mortality (RR, 0.48; 95% CI, 0.25-0.92) and fascial closure (RR, 1.5; 95% CI, 1.1-2.0) for patients who received the ABThera versus Barker's vacuum pack. Another noted a reduced arterial lactate, intra-abdominal pressure, and hospital stay for those fitted with the KCI VAC versus Bogota bag. Most included retrospective studies exhibited low methodological quality and reported no mortality or fascial closure benefit for NPWT.
   CONCLUSION: Limited prospective comparative data suggests that NPWT versus alternate TAC techniques may be linked with improved outcomes. However, the clinical heterogeneity and quality of available studies preclude definitive conclusions regarding the preferential use of NPWT over alternate TAC techniques. (J Trauma Acute Care Surg. 2012; 73: 629-639. Copyright (C) 2012 by Lippincott Williams & Wilkins)
C1 [Roberts, Derek J.; Grendar, Jan; Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Univ Calgary, Dept Surg, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.; Kirkpatrick, Andrew W.] Univ Calgary, Dept Crit Care Med, Calgary, AB T2N 2T9, Canada.
   [Zygun, David A.] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada.
   [Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Univ Calgary, Reg Trauma Program, Calgary, AB T2N 2T9, Canada.
   [Robertson, Helen Lee] Univ Calgary, Hlth Sci Lib, Calgary, AB T2N 2T9, Canada.
   [Roberts, Derek J.; Zygun, David A.; Grendar, Jan; Ball, Chad G.; Ouellet, Jean-Francois; Kirkpatrick, Andrew W.] Foothills Med Ctr, Calgary, AB, Canada.
   [Cheatham, Michael L.] Orlando Reg Med Ctr Inc, Dept Surg Educ, Orlando, FL USA.
C3 University of Calgary; University of Calgary; University of Calgary;
   University of Calgary; University of Calgary; University of Calgary;
   University of Calgary; University Calgary Hospital; Orlando Health;
   Orlando Regional Medical Center
RP Kirkpatrick, AW (通讯作者)，Univ Calgary, Dept Surg, 1403-29th St, Calgary, AB T2N 2T9, Canada.
EM Andrew.Kirkpatrick@AlbertaHealthServices.Ca
RI Roberts, Derek/L-6229-2019; Robertson, Helen Lee/AAH-2875-2019
OI Roberts, Derek/0000-0001-6111-6291; Robertson, Helen
   Lee/0000-0002-2348-2239
FU University of Calgary; KCI [KCI Clinical/University Calgary Alberta
   Health/082611-000/7]; KCI USA
FX Dr. Kirkpatrick has an investigator-initiated trial agreement with KCI
   USA and the Governors of the University of Calgary for funding of a
   randomized comparison of baseline wall suction and the ABThera open
   abdomen NPT system for adults with critical illness and open abdominal
   wounds (KCI contract number: KCI Clinical/University Calgary Alberta
   Health/082611-000/7). Dr. Cheatham has received compensation from KCI
   USA as a lecturer and is an investigator on the included ABTAC-50 study.
   The remaining authors have no conflicts of interest to declare. Dr.
   Roberts is supported by funding from the Clinician Investigator and
   Surgeon Scientist Programs at the University of Calgary. These
   institutions had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data; or
   preparation, review, or approval of the article.
CR [Anonymous], 5 WORLD C ABD COMP S
   [Anonymous], COCHRANE HDB SYSTEMA
   [Anonymous], USE TOPICAL NEGATIVE
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NR 48
TC 92
Z9 114
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD SEP
PY 2012
VL 73
IS 3
BP 629
EP 639
DI 10.1097/TA.0b013e31825c130e
PG 11
WC Critical Care Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Surgery
GA 009TK
UT WOS:000309047900015
PM 22929494
DA 2026-07-24
ER

PT J
AU Pujji, O
   Farrar, E
   Jeffery, S
AF Pujji, Ojas
   Farrar, Edmund
   Jeffery, Steven
TI Negative Pressure Wound Therapy to the Dura
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID DERMAL REGENERATION TEMPLATE
AB Negative-pressure wound therapy is historically contraindicated in patients with osteomyelitis or exposed dura. The authors present a case of a complex reconstruction of an infected full thickness scalp burn, where negative-pressure wound therapy was successfully used over the dura.
C1 [Pujji, Ojas] Univ Birmingham, Sch Med, Birmingham, W Midlands, England.
   [Farrar, Edmund] Queen Elizabeth Hosp, Burns & Plast Surg, MOD FY2, Birmingham, W Midlands, England.
   [Jeffery, Steven] Queen Elizabeth Hosp, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham
RP Pujji, O (通讯作者)，Univ Birmingham, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
EM oxp225@bham.ac.uk; edmund.farrar@nhs.net; sjeffery@nhs.net
RI jeffery, steven/A-5207-2013
OI jeffery, steven/0000-0001-6587-5412
CR A Novak, 2014, Open Orthop J, V8, P168, DOI 10.2174/1874325001408010168
   Cheney M, 2014, FACIAL SURG PLASTIC
   Foong DPS, 2013, J PLAST RECONSTR AES, V66, P1717, DOI 10.1016/j.bjps.2013.07.007
   Henderson V., 2010, WOUNDS INT, V1, P1
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Jeffery SLA, 2009, TRAUMA, V11, P241, DOI 10.1177/1460408609350126
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NR 17
TC 2
Z9 2
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1559-047X
EI 1559-0488
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAY-JUN
PY 2018
VL 39
IS 3
BP 463
EP 467
DI 10.1097/BCR.0000000000000578
PG 5
WC Critical Care Medicine; Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Dermatology; Surgery
GA GD8AB
UT WOS:000430733400019
PM 28570314
DA 2026-07-24
ER

PT J
AU Dohmen, PM
AF Dohmen, Pascal M.
TI Letter to the Editor regarding: Negative pressure wound therapy
SO MEDICAL SCIENCE MONITOR
LA English
DT Letter
DE Negative-Pressure Wound Therapy; Skin Transplantation; Wound Closure
   Techniques
C1 [Dohmen, Pascal M.] Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, Saxony, Germany.
   [Dohmen, Pascal M.] Univ Orange Free State, Dept Cardiothorac Surg, Bloemfontein, South Africa.
C3 Heart Center Leipzig GMBH; Leipzig University; University of the Free
   State
RP Dohmen, PM (通讯作者)，Univ Leipzig, Heart Ctr Leipzig, Dept Cardiac Surg, Saxony, Germany.
EM pascal.dohmen@yahoo.de
CR Dohmen PM, 2014, EXPERT REV IN PRESS
   Wang XG, 2014, MED SCI MONITOR, V20, P61, DOI 10.12659/MSM.889861
NR 2
TC 2
Z9 2
U1 0
U2 2
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD APR 23
PY 2014
VL 20
BP 681
EP 682
DI 10.12659/MSM.890863
PG 2
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AF8BM
UT WOS:000334940000001
PM 24759432
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Ko, YS
   Jung, SW
AF Ko, Yoon Song
   Jung, Sung Won
TI Vacuum-assisted close versus conventional treatment for postlaparotomy
   wound dehiscence
SO ANNALS OF SURGICAL TREATMENT AND RESEARCH
LA English
DT Article
DE Vacuum-assisted closure; Dehiscence; Wound
ID INCISIONAL HERNIA; PREVENTION; OPERATIONS; TRAUMA
AB Purpose: The conventional treatment for postlaparotomy wound dehiscence usually involves surgical revision. Recently, vacuum-assisted closure has been successfully used in postlaparotomy wound dehiscence. The aim of the present study was to compare the clinical outcome of 207 patients undergoing vacuum-assisted closure therapy or conventional treatment for postlaparotomy wound dehiscence.
   Methods: Two hundred and seven consecutive patients underwent treatment for postlaparotomy wound dehiscence: vacuum-assisted closure therapy (January 2007 through August 2012, n = 25) or conventional treatment (January 2001 through August 2012, n = 182).
   Results: The failure rate to first-line treatment with vacuum-assisted closure and conventional treatment were 0% and 14.3%, respectively (P = 0.002). There was no statistically significant difference in the enterocutaneous fistulas and hospital stay after vacuum-assisted closure therapy or conventional treatment respectively.
   Conclusion: Our findings support that vacuum-assisted closure therapy is a safe and reliable option in postlaparotomy wound dehiscence with very low failure rate in surgical revision compared with conventional treatment.
C1 [Ko, Yoon Song; Jung, Sung Won] Korea Univ, Coll Med, Anam Hosp, Dept Surg, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Jung, SW (通讯作者)，Korea Univ, Coll Med, Anam Hosp, Div HBP Surg & Liver Transplantat,Dept Surg, 73 Inchon Ro, Seoul 136705, South Korea.
EM sungwon94@naver.com
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NR 13
TC 4
Z9 5
U1 0
U2 3
PU KOREAN SURGICAL SOCIETY
PI SEOUL
PA 3304HO, 101 DONG, BROWNSTONE SEOUL, 335, JUNGMIN-DONG, JUNG-GU, SEOUL,
   100-859, SOUTH KOREA
SN 2288-6575
EI 2288-6796
J9 ANN SURG TREAT RES
JI Ann. Surg. Treat. Res.
PD NOV
PY 2014
VL 87
IS 5
BP 260
EP 264
DI 10.4174/astr.2014.87.5.260
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AS3UM
UT WOS:000344203500006
PM 25368852
OA hybrid
DA 2026-07-24
ER

PT J
AU Mattox, EA
AF Mattox, Elizabeth Andersson
TI Reducing Risks Associated With Negative-Pressure Wound Therapy:
   Strategies for Clinical Practice
SO CRITICAL CARE NURSE
LA English
DT Article
ID EVIDENCE-BASED RECOMMENDATIONS; SURGICAL SITE INFECTION; COST; SURGERY;
   STEPS; FOAM
AB Negative-pressure wound therapy represents a relatively new strategy for wound management. Significant, life-threatening complications (bleeding, infection, and retained dressing material) have been associated with negative-pressure wound therapy. As a result, the Food and Drug Administration published several warnings to negative-pressure wound therapy users and recommended that clinicians ordering, managing, and/or monitoring negative-pressure wound therapy be aware of the potential complications and be prepared to take prompt action to reduce patients' risk for harm. This article reviews and organizes published consensus, expert opinion, research, and manufacturer guidelines about patient safety during negative-pressure wound therapy relevant to nurses practicing in acute and critical care settings, including in advanced practice roles. (Critical Care Nurse. 2017; 37[ 5]: 67-77)
C1 [Mattox, Elizabeth Andersson] VA Puget Sound Hlth Care Syst, Pulm & Crit Care Med Sect, Seattle, WA 98108 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System
RP Mattox, EA (通讯作者)，VA Puget Sound Hlth Care Syst, 1660 S Columbian Way, Seattle, WA 98108 USA.
EM eamattox@gmail.com
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NR 67
TC 14
Z9 17
U1 0
U2 12
PU AMER ASSOC CRITICAL CARE NURSES
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 0279-5442
EI 1940-8250
J9 CRIT CARE NURSE
JI Crit. Care Nurse
PD OCT
PY 2017
VL 37
IS 5
BP 67
EP 77
DI 10.4037/ccn2017308
PG 11
WC Critical Care Medicine; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Nursing
GA FI9YI
UT WOS:000412365200007
PM 28966197
DA 2026-07-24
ER

PT J
AU Sari, A
   Fesli, A
   Yener, T
   Basterzi, Y
   Demirkan, F
AF Sari, Alper
   Fesli, Atilla
   Yener, Tolga
   Basterzi, Yavuz
   Demirkan, Ferit
TI The Efficacy of Topical Negative Pressure in the Management of Infected
   and Non-infected Wounds
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; THERAPY; FOUNDATION; TRIAL; STATE
AB This study evaluates the efficacy of a vacuum-assisted closure (V.A.C.(R) Therapy, KCl, San Antonio, Tex) device in the comparative management of clean and infected wounds. Vacuum-assisted closure was applied to 57 wounds of 51 patients. Methods. Our protocol consisted of debridement of all necrotic tissue followed by vacuum-assisted closure therapy along with appropriate antibiotic administration. In 5 cases with peripheral circulation impairment, vacuum-assisted closure therapy was terminated due to a poor tissue response. In the remaining 52 wounds, healthy granulation tissue generation was observed. Wound cultures obtained from these patients prior to the start of vacuum-assisted closure proved the presence of infection. Results. The average sizes of the infected and non-infected wounds were 55.77 cm(2) and 57.94 cm(2) prior to the start of vacuum-assisted closure, respectively, while they were reduced to 48.28 cm(2) and 45.70 cm(2) after the last session. At the conclusion of vacuum-assisted closure therapy, 42 wounds were skin grafted and 10 wounds were covered with skin/muscle flaps. Conclusion. Vacuum-assisted closure therapy is a reliable tool in the management of almost any type of wound, whether infected or not infected, unless major circulatory impairment interferes and acted as a contributary factor in wound formation.
C1 [Sari, Alper; Fesli, Atilla; Yener, Tolga; Basterzi, Yavuz; Demirkan, Ferit] Mersin Univ, Dept Plast & Reconstruct Surg, Mersin, Turkey.
C3 Mersin University
RP Sari, A (通讯作者)，Mersin Univ, Kampusu 33343, Mezitli Mersin, Turkey.
EM dralpersari@yahoo.com
RI /G-5030-2015
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
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NR 16
TC 1
Z9 1
U1 0
U2 2
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD APR
PY 2009
VL 21
IS 4
BP 95
EP 101
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 435QD
UT WOS:000265357500004
PM 25903231
DA 2026-07-24
ER

PT J
AU Gao, HQ
   Cheng, XH
   Gao, LJ
   Wang, W
   Wang, XQ
   Gong, FR
   Zhang, MM
   Hu, J
AF Gao, Hengqing
   Cheng, Xiaohong
   Gao, Lijuan
   Wang, Wei
   Wang, Xiaoqiang
   Gong, Furao
   Zhang, Mengmeng
   Hu, Jing
TI Time-scheduled dotted and solid thread-ligating therapy combined with
   vacuum sealing drainage for treating high complex anal fistula
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Time-scheduled dotted and solid thread-ligating; vacuum sealing
   drainage; clinical efficacy; anal function
ID RESOLUTION ANORECTAL MANOMETRY; MANAGEMENT
AB Objective: To investigate the treatment of high complex anal fistula with time-scheduled dotted and solid thread-ligating therapy combined with vacuum sealing drainage. Methods: A retrospective cohort study of 80 patients with high complex anal fistula admitted to the anorectal department of our hospital was conducted. The patients in the control group (n=40) were treated with traditional incision thread-ligating therapy, while the patients in the observation group (n=40) were treated with time-scheduled dotted and solid thread-ligating therapy combined with vacuum sealing drainage. The postoperative wound healing time, clinical efficacy, postoperative pain scores as well as pre- and postoperative anal function and anorectal pressure of patients in the two groups were observed. Results: The observation group had a shorter wound healing time (P<0.001), lower postoperative pain scores (P<0.05), a lower increase of Wexner score (P<0.001), a higher total effective rate (97.50% vs. 90.00%; P>0.05), a higher anal maximal contraction pressure and a larger high pressure zone than the control group (P<0.05). Compared with those before operation, the Wexner scores of patients in the two groups after operation were increased, while the anal maximal contraction pressure and high pressure zone in the control group were decreased (P<0.001). Conclusion: The treatment of complex high anal fistula with time-scheduled dotted and solid thread-ligating combined with vacuum sealing drainage has short wound healing time, high efficiency, and little influence on the postoperative function of anal sphincter. It is worthy to be popularized in clinic.
C1 [Gao, Hengqing; Gao, Lijuan; Wang, Wei; Wang, Xiaoqiang; Gong, Furao] Zigong Hosp Chinese Tradit Med, Dept Anorectal, Zigong 643010, Sichuan, Peoples R China.
   [Cheng, Xiaohong] Zigong Hosp Chinese Tradit Med, Dept Pharm, Zigong 643010, Sichuan, Peoples R China.
   [Hu, Jing] Zigong Hosp Chinese Tradit Med, Dept Sci & Educ, Zigong 643010, Sichuan, Peoples R China.
   [Zhang, Mengmeng] Chengdu Univ Tradit Chinese Med, Grad Sch, 37 Twelve Bridge Rd, Chengdu 610072, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Zhang, MM (通讯作者)，Chengdu Univ Tradit Chinese Med, Grad Sch, 37 Twelve Bridge Rd, Chengdu 610072, Sichuan, Peoples R China.
EM zhangmengmeng512@163.com
RI wang, xiaoqiang/LXV-9628-2024
FU Special Pro-ject of Sichuan Provincial Administration of Traditional
   Chinese Medicine (Sichuan Traditional Chinese Medicine Office) [22-444]
FX This work was supported by the Special Pro-ject of Sichuan Provincial
   Administration of Traditional Chinese Medicine (Sichuan Traditional
   Chinese Medicine Office No. 22-444, 2020) .
CR Actis GC, 2019, J CLIN MED, V8, DOI 10.3390/jcm8111970
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NR 25
TC 3
Z9 5
U1 0
U2 16
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 10
BP 11737
EP 11744
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA WR8WN
UT WOS:000714775300026
PM 34786101
DA 2026-07-24
ER

PT J
AU Zhang, CM
   Wang, Q
   Wang, ZM
   Huang, Q
   Zhang, CC
   Duan, N
   Lin, H
   Ma, T
   Zhang, K
   Xue, HZ
   Li, Z
AF Zhang, Congming
   Wang, Qian
   Wang, Zhimeng
   Huang, Qiang
   Zhang, Chenchen
   Duan, Ning
   Lin, Hua
   Ma, Teng
   Zhang, Kun
   Xue, Hanzhong
   Li, Zhong
TI Modified negative-pressure wound therapy for linear blister formation
   prevention around foam dressings: technical note and case series
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Linear blister prevention; Open fracture; Surgical technique;
   Negative-pressure wound therapy
ID VACUUM SEALING DRAINAGE; ASSISTED CLOSURE; TIBIAL FRACTURES; LOWER-LIMB;
   MANAGEMENT; INFECTION
AB Background Linear blisters (LBs) often occur around dressings when negative-pressure wound therapy (NPWT) is used to cover open wounds. Tension blisters may increase the wound infection incidence rate, delay the start of operation, and prolong the duration of hospital stay. Currently, there are no established methods for the prevention of LB formation around dressings, which remains to be a major concern in clinical applications. Therefore, we developed a novel, simple, reproducible, and convenient method for preventing LB formation around NPWT dressings. Method Fifty-three cases of Gustilo type II and III open fractures under NPWT were considered. NPWT was used on every wound after debridement. All patients were divided into a conventional group (27 cases, 33 wounds) and a novel group (26 cases, 27 wounds) based on the difference in the NPWT dressing appearance. A healthy volunteer with intact skin was also included to perform the detailed process of NPWT. LBs occurring on intact skin around the dressings were observed and recorded when the dressing was removed 3 days after the operation. The occurrence of LB formation and wound infection was considered as categorical data and compared between the two groups using a chi-square test. The duration of hospital stay was considered as numerical data and compared between the two groups using two independent t tests. Results The percentage of occurrence of LB formation around dressings in the conventional group was 27.3%, whereas it was merely 3.7% in the novel group (P = 0.037). The infection incidence rate in the conventional group was 30.3%, whereas that in the novel group was 25.9%; however, no statistical difference was observed between the two groups (P = 0.708). The average duration of hospital stay in the conventional group was 14.39 +/- 4.55 days, whereas that in the novel group was 11.04 +/- 3.47 days (P = 0.003). Conclusion Thus, changing the NPWT dressing appearance can prevent LB formation around dressings, providing an effective method to improve NPWT application. Modified NPWT dressings also shorten the duration of hospital stay, but do not significantly decrease the incidence of wound infection.
C1 [Zhang, Congming; Wang, Qian; Wang, Zhimeng; Huang, Qiang; Zhang, Chenchen; Duan, Ning; Lin, Hua; Ma, Teng; Zhang, Kun; Xue, Hanzhong; Li, Zhong] Xi An Jiao Tong Univ, Coll Med, Hong Hui Hosp, Dept Orthopaed & Traumatol, 555 Youyi Rd, Xian 710054, Peoples R China.
C3 Xi'an Jiaotong University
RP Xue, HZ; Li, Z (通讯作者)，Xi An Jiao Tong Univ, Coll Med, Hong Hui Hosp, Dept Orthopaed & Traumatol, 555 Youyi Rd, Xian 710054, Peoples R China.
EM 13759963709@163.com; lizhong0607@126.com
RI Zhang, Chenchen/GPW-7947-2022; Zhang, Kun/S-5005-2019
FU Project of Science and Technology Department of Shaanxi Province
   [2016JM8151, 2016SF-340]
FX This study was financially supported by the Project of Science and
   Technology Department of Shaanxi Province (2016JM8151, 2016SF-340).
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NR 24
TC 8
Z9 8
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 15
PY 2021
VL 16
IS 1
AR 602
DI 10.1186/s13018-021-02759-x
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA WH3KC
UT WOS:000707580200003
PM 34654453
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Dini, V
   Oranges, T
   Rotella, L
   Romanelli, M
AF Dini, Valentina
   Oranges, Teresa
   Rotella, Luca
   Romanelli, Marco
TI Hidradenitis Suppurativa and Wound Management
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Review
DE hidradenitis suppurativa; acne inversa; wound care
ID VACUUM-ASSISTED CLOSURE; SURGICAL-TREATMENT; TREATMENT OPTION; CASE
   SERIES; EXCISION; LASER; CLINDAMYCIN; PREVALENCE; INFLIXIMAB; ADALIMUMAB
AB Hidradenitis suppurativa (HS) is a chronic, burdensome, debilitating disease of the hair follicle. It presents with recurrent painful inflamed and noninflamed lesions usually in specific body areas such as axillary, inguinal, perineal, and genital areas. It is associated with a large range of other diseases and conditions, such as obesity, arthropathy, inflammatory bowel diseases, and sqaumous cell carcinoma. Medical therapy may be systemic or topical, mainly based on antibiotics, retinoids, hormones and immunosuppressive drugs, including biological therapies. Surgical and laser therapies may be a valid therapeutic approach in order to treat locally recurring lesions. The aim of this article is to review the wound healing options after skin excision and laser treatments, with a focus on lesions left to heal by secondary intention, analyzing the efficacy of moist wound dressings, negative pressure wound therapy, bioactive dressings, such as platelet-rich plasma gel and hylarunoic acid scaffold, or autologous keratinocyte suspension in platelet concentrate and skin-grafting tecniques.
C1 [Dini, Valentina; Oranges, Teresa; Rotella, Luca; Romanelli, Marco] Univ Pisa, I-56126 Pisa, Italy.
C3 University of Pisa
RP Dini, V (通讯作者)，Univ Pisa, Dept Clin & Expt Med, Dermatol Unit, Via Roma 67, I-56126 Pisa, Italy.
EM valentina.dini@unipi.it
RI ; Oranges, Teresa/AAM-9690-2020; romanelli, marco/ABI-1154-2020; dini,
   valentina/F-7747-2017
OI Rotella, Luca/0000-0003-0141-6369; Oranges, Teresa/0000-0002-7277-3278;
   romanelli, marco/0000-0002-4127-0141; dini,
   valentina/0000-0002-8537-1999
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NR 75
TC 28
Z9 29
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD SEP
PY 2015
VL 14
IS 3
SI SI
BP 236
EP 244
DI 10.1177/1534734615598890
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CT3MN
UT WOS:000362710900006
PM 26248827
DA 2026-07-24
ER

PT J
AU Hu, C
   Zhang, TG
   Deng, ZM
   Ren, B
   Cai, L
   Zhang, Y
   Yan, L
AF Hu, Chao
   Zhang, Taogen
   Deng, Zhouming
   Ren, Bin
   Cai, Lin
   Zhang, Yi
   Yan, Lei
TI Study on the effect of vacuum sealing drainage on the repair process of
   rabbit sciatic nerve injury
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE vacuum sealing drainage; sciatic nerve; nerve repair
ID PRESSURE WOUND THERAPY; NEUROTROPHIC FACTOR; NEGATIVE-PRESSURE; ASSISTED
   CLOSURE; PERIPHERAL-NERVE; AXONAL REGENERATION; GROWTH-FACTOR; BDNF;
   PROMOTE; BONE
AB Purpose: To investigate the influence of vacuum sealing drainage on sciatic nerve repair after injury in rabbits. Materials and Methods: Twenty four New Zealand white rabbits were randomly divided into experimental group and control group. About 1cm sciatic nerve was transected and sutured back in situ. The experimental group had vacuum sealing drainage assisted wound closure whereas the control group had normal wound closure. The nerve repair rate was compared based on nerve conduction velocity, lower leg triceps wet weight recovery rate, histology, immunohistochemical of brain-derived neurotrophic factor, and ultrastructure observation of regenerated nerve by electron microscopy at the 4th and 8th week after surgery. Results: At the 1st-2nd weeks after surgery, irritation and ulcers were observed on the surgical side in both the experimental group and the control group. At the 4th and 8th week after surgery, electrical nerve conduction velocity in the experimental group was faster than in the control group (p < 0.05) and triceps muscle calf wet weight recovery rate in the experimental group was higher than that in the control group (p < 0.05). Brain-derived neurotrophic factor immunohistochemical staining intensity in the experimental group was higher than that in the control group (p < 0.05) and toluidine blue staining and electron microscopic observation showed that the nerve regeneration and repair were more pronounced in the experimental group as compared to the control group. Myelinated nerve fibers in the experimental group were more than that in the control group at the 4th week and 8th week after surgery. Conclusion: Vacuum sealing drainage facilitates repair of peripheral nerve injury.
C1 [Hu, Chao; Deng, Zhouming; Cai, Lin; Zhang, Yi; Yan, Lei] Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei Province, Peoples R China.
   [Zhang, Taogen] Peoples Hosp Daye City, Dept Orthoped, Daye, Hubei Province, Peoples R China.
   [Ren, Bin] Wuhan Univ, Zhongnan Hosp, Dept Radio Chemo Therapy, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University; Wuhan University
RP Cai, L (通讯作者)，Wuhan Univ, Zhongnan Hosp, Dept Orthoped, 169th Donghu Rd, Wuhan 430071, Hubei Province, Peoples R China.
EM guke3559@aliyun.com
RI Li, Caiting/ABD-6818-2021
OI Hu, Chao/0000-0001-9093-2642
FU Fundamental Research Funds for Central Universities [2012303020207]
FX This work is supported by the Fundamental Research Funds for the Central
   Universities (No. 2012303020207).
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NR 27
TC 7
Z9 9
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0020-7454
EI 1563-5279
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PD NOV 2
PY 2015
VL 125
IS 11
BP 855
EP 860
DI 10.3109/00207454.2014.979981
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CX3DL
UT WOS:000365575600009
PM 25340255
DA 2026-07-24
ER

PT J
AU Malmsjö, M
   Ingemansson, R
   Sjögren, J
AF Malmsjo, Malin
   Ingemansson, Richard
   Sjogren, Johan
TI Mechanisms governing the effects of vacuum-assisted closure in cardiac
   surgery
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID TOPICAL NEGATIVE-PRESSURE; STERNAL WOUND INFECTIONS; SUBATMOSPHERIC
   PRESSURE; HYPERBARIC-OXYGEN; SHEAR-STRESS; BLOOD-FLOW; THERAPY; DEEP;
   MEDIASTINITIS; RECRUITMENT
AB Vacuum-assisted closure has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome achieved with its use. Scientific evidence regarding the mechanisms by which vacuum-assisted closure promotes wound healing has started to emerge, although knowledge regarding the effects on heart and lung function is still limited. The organs in the mediastinum are hemodynamically crucial, and in patients with poststernotomy mediastinitis, vulnerable bypass grafts and reduced cardiac function must be taken into consideration during vacuum-assisted closure therapy. This article provides an overview of the effects of vacuum-assisted closure on heart and lung function and summarizes the current knowledge on the mechanisms by which vacuum-assisted closure therapy promotes wound healing.
C1 Univ Lund Hosp, Dept Med, SE-22184 Lund, Sweden.
   Univ Lund Hosp, Dept Cardiothorac Surg, SE-22184 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Univ Lund Hosp, Dept Med, BMC A13, SE-22184 Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI Sjögren, Johan/AAZ-6448-2021
OI Maljö, Malin/0000-0001-9849-9599; Ingemansson,
   Richard/0000-0001-7623-8953
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NR 73
TC 35
Z9 36
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD OCT
PY 2007
VL 120
IS 5
BP 1266
EP 1275
DI 10.1097/01.prs.0000279326.84535.2d
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 217VZ
UT WOS:000249976700020
PM 17898599
DA 2026-07-24
ER

PT J
AU Zhang, C
   Liu, LY
   Chen, T
AF Zhang, Chi
   Liu, Liyin
   Chen, Tao
TI Application of Nice knot combined with vacuum-sealing drainage technique
   in the treatment of infected skin and soft tissue defect
SO ASIAN JOURNAL OF SURGERY
LA English
DT Letter
C1 [Zhang, Chi; Liu, Liyin; Chen, Tao] Anhui 2 Prov Peoples Hosp, Dept Orthopaed, Hefei 230000, Peoples R China.
RP Chen, T (通讯作者)，Anhui 2 Prov Peoples Hosp, Dept Orthopaed, Hefei 230000, Peoples R China.
EM zc163official@163.com
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PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD APR
PY 2024
VL 47
IS 4
BP 1867
EP 1868
DI 10.1016/j.asjsur.2023.12.154
EA MAR 2024
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA QE8O9
UT WOS:001219296300001
PM 38182517
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Anderson, CA
   Hare, MA
   Perdrizet, GA
AF Anderson, Caesar A.
   Hare, Marc A.
   Perdrizet, George A.
TI Wound Healing Devices Brief Vignettes
SO ADVANCES IN WOUND CARE
LA English
DT Review
ID HYPERBARIC-OXYGEN THERAPY; VACUUM-ASSISTED CLOSURE; RANDOMIZED
   CONTROLLED-TRIAL; DIABETIC FOOT ULCERS; SOFT-TISSUE INFECTIONS; PRESSURE
   ULCERS; DOUBLE-BLIND; ULTRASOUND; MULTICENTER; MANAGEMENT
AB Significance: The demand for wound care therapies is increasing. New wound care products and devices are marketed at a dizzying rate. Practitioners must make informed decisions about the use of medical devices for wound healing therapy. This paper provides updated evidence and recommendations based on a review of recent publications.
   Recent Advances: The published literature on the use of medical devices for wound healing continues to support the use of hyperbaric oxygen therapy, negative pressure wound therapy, and most recently electrical stimulation.
   Critical Issue: To inform wound healing practitioners of the evidence for or against the use of medical devices for wound healing. This information will aid the practitioner in deciding which technology should be accepted or rejected for clinical use.
   Future Directions: To produce high quality, randomized controlled trials or acquire outcome-based registry databases to further test and improve the knowledge base as it relates to the use of medical devices in wound care.
C1 [Anderson, Caesar A.; Hare, Marc A.; Perdrizet, George A.] Univ Calif San Diego, Dept Emergency Med, Ctr Wound Healing & Hyperbar Med, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Perdrizet, GA (通讯作者)，UC San Diego Hlth Syst, Dept Emergency Med, 200 W Arbor Dr,MC8676, San Diego, CA 92103 USA.
EM gperdrizet@UCSD.edu
FU OxyHeal Corp. (San Diego, CA)
FX C.A.A., M.A.H., and G.A.P. have no competing financial interests. G.A.P.
   has received funding for basic science research from OxyHeal Corp. (San
   Diego, CA). The content of this article was expressly written by the
   authors listed. No ghostwriters were used to write this article.
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NR 46
TC 8
Z9 8
U1 2
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD APR 1
PY 2016
VL 5
IS 4
BP 185
EP 190
DI 10.1089/wound.2015.0651
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DH5RU
UT WOS:000372850300004
PM 27076996
DA 2026-07-24
ER

PT J
AU Melvin, JS
   Dombroski, DG
   Torbert, JT
   Kovach, SJ
   Esterhai, JL
   Mehta, S
AF Melvin, J. Stuart
   Dombroski, Derek G.
   Torbert, Jesse T.
   Kovach, Stephen J.
   Esterhai, John L.
   Mehta, Samir
TI Open Tibial Shaft Fractures: I. Evaluation and Initial Wound Management
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID OPEN EXTREMITY FRACTURES; VACUUM-ASSISTED CLOSURE; SOFT-TISSUE;
   ANTIBIOTIC-THERAPY; INFECTION-RATE; BONE; PRESSURE; LAVAGE; IRRIGATION;
   BACTERIA
AB Open fractures of the tibial diaphysis are often associated with severe bone and soft-tissue injury. Contamination of the fracture site and devitalization of the soft-tissue envelope greatly increase the risk of infection, nonunion, and wound complications. Management of open tibial shaft fractures begins with a thorough patient evaluation, including assessment of the bone and soft tissue surrounding the tibial injury. Classification of these injuries according to the system of Gustilo and Anderson at the time of surgical debridement is useful in guiding treatment and predicting outcomes. Administration of antibiotic prophylaxis as soon as possible after injury as well as urgent and thorough debridement, irrigation, and bony stabilization are done to minimize the risk of infection and improve outcomes. The use of antibiotic bead pouches and negative-pressure wound therapy has proved to be efficacious for the acute, temporary management of severe bone and soft-tissue defects.
C1 [Melvin, J. Stuart; Dombroski, Derek G.; Torbert, Jesse T.; Esterhai, John L.] Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA.
   [Kovach, Stephen J.] Univ Penn, Div Plast Surg, Philadelphia, PA 19104 USA.
   [Mehta, Samir] Univ Penn, Orthopaed Trauma & Fracture Serv, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania
RP Melvin, JS (通讯作者)，Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA.
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NR 48
TC 88
Z9 114
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD JAN
PY 2010
VL 18
IS 1
BP 10
EP 19
PG 10
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 543LD
UT WOS:000273578100002
PM 20044487
DA 2026-07-24
ER

PT J
AU Gabriel, A
   Heinrich, C
   Shores, JT
   Baqai, WK
   Rogers, FR
   Gupta, S
AF Gabriel, Allen
   Heinrich, Cherrie
   Shores, Jaimie T.
   Baqai, Waheed K.
   Rogers, Frank R.
   Gupta, Subhas
TI Reducing bacterial bioburden in infected wounds with vacuum assisted
   closure and a new silver dressing - A pilot study
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID SKIN-GRAFTS; SUBATMOSPHERIC PRESSURE; ANTIMICROBIAL ACTIVITY; EFFICACY;
   THERAPY; SAFETY
AB The use of silver is increasing rapidly in the management of infected wounds and wounds at risk for infection. This 5-patient case series reviews the results of a pilot study designed to determine efficacy and safety of negative pressure wound therapy (NPWT; V.A.C.(R) Therapy(TM), KCl, San Antonio, Tex) with the new silver foam dressing (V.A.C.(R) GranuFoam(R) Silver(TM) Dressing, KCl). Data on wound progression and the primary endpoints-time to clear infection, time to wound closure, and time to discharge from hospital-are detailed in this manuscript. For the 5 patients treated with NPWT and the silver foam dressing, the mean time for treatment was 13.00 +/- 3.39 days and the mean time to patient discharge was 16.00 +/- 6.63 days. Wounds were clear of clinical signs of infection in 7.00 +/- 1.58 days and closed in 19.20 +/- 8.76 days.
C1 Loma Linda Univ, Dept Surg, Div Plast & Reconstruct Surg, Loma Linda, CA 92354 USA.
   Loma Linda Univ, Ctr Hlth Res, Loma Linda, CA 92354 USA.
C3 Loma Linda University; Loma Linda University
RP Gupta, S (通讯作者)，Loma Linda Univ, Dept Surg, Div Plast & Reconstruct Surg, 11175 Campus Dr,Coleman Pavil 21126, Loma Linda, CA 92354 USA.
EM sgupta@ahs.llumc.edu
RI Gupta, Subhas/C-5458-2018; Gabriel, Allen/AFK-3548-2022
OI Gupta, Subhas/0000-0001-5091-3922; 
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NR 39
TC 22
Z9 28
U1 0
U2 0
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD SEP
PY 2006
VL 18
IS 9
BP 245
EP 255
PG 11
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 091QB
UT WOS:000241042300001
DA 2026-07-24
ER

PT J
AU Buchanan, PJ
   Kung, TA
   Cederna, PS
AF Buchanan, Patrick J.
   Kung, Theodore A.
   Cederna, Paul S.
TI Evidence-Based Medicine: Wound Closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID FREE-TISSUE TRANSFER; VACUUM-ASSISTED CLOSURE; CIGARETTE-SMOKING;
   SKIN-GRAFTS; BACTERIAL INOCULATION; PERFORATOR FLAP; BLOOD-FLOW;
   SURGERY; PROTEIN; RECONSTRUCTION
AB Learning Objectives: After reading this article, the participant should be able to: 1. Describe various wound closure techniques available to the modern plastic surgeon, including the indications and contraindications of each. 2. Explain the fundamental concepts of wound healing as it relates to reconstruction. 3. Understand the role of commonly used reconstructive adjuncts such as negative-pressure wound therapy, dermal substitutes, and tissue expansion. 4. Assess the important patient factors that may influence the strategy for surgical wound closure.
   Summary: Successful wound closure requires a comprehensive approach that includes consideration of suitable surgical techniques and critical patient factors. A clear understanding of key concepts such as wound healing, flap design, and patient risk assessment is imperative to a favorable outcome. In this Maintenance of Certification/Continuing Medical Education article, the reader is provided a summary of the available surgical options for wound closure and a discussion of the algorithm used to choose the most appropriate reconstructive strategy.
C1 [Buchanan, Patrick J.; Kung, Theodore A.; Cederna, Paul S.] Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan
RP Cederna, PS (通讯作者)，Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, Taubman Ctr 2130, 1500 East Med Ctr Dr,SPC 5340, Ann Arbor, MI 48109 USA.
EM cederna@med.umich.edu
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NR 95
TC 28
Z9 36
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2016
VL 138
SU S
BP 257S
EP 270S
DI 10.1097/PRS.0000000000002775
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EI6PQ
UT WOS:000392618300032
PM 27556770
DA 2026-07-24
ER

PT J
AU Bernstein, BH
   Tam, H
AF Bernstein, BH
   Tam, H
TI Combination of subatmospheric pressure dressing and gravity feed
   antibiotic instillation in the treatmetn of post-surgical diabetic foot
   wounds: A case series
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SUCTION IRRIGATION; PMMA-BEADS; THERAPY;
   GENTAMICIN; BONE; SKIN
AB A new negative pressure wound therapy (NPWT) device with solution instillation capability (V.A.C.(R)- Instill(TM), KCI, San Antonio, Tex) will be discussed. Historical delivery methods for local antibiotic levels directly to the post-surgical field are antibiotic-laced beads, Kritter-type instillation catheters, and closed suction irrigation. These devices will be reviewed and contrasted with both traditional NPWT as well as the new NPWT with instillation. The authors present 5 diabetic foot surgical case studies highlighting the use of NPWT with instillation followed by a discussion of the reduced length of stay demonstrated in the case studies. The basis of both moist wound healing and wound irrigation will be discussed. The pros and cons of various topical solution choices will be reviewed. The authors will also present a list of scenarios in which the new NPWT with instillation option should be considered.
C1 Staten Isl Univ Hosp, Diabet Food Team, Staten Isl, NY USA.
   Tidewater Foot & Angkle Res Fdn Fellowship, Virginia Beach, VA USA.
C3 Northwell Health
RP Bernstein, BH (通讯作者)，623 W Union Blvd, Bethlehem, PA 18018 USA.
EM daktari6@netzero.com
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NR 56
TC 36
Z9 53
U1 0
U2 6
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD FEB
PY 2005
VL 17
IS 2
BP 37
EP 48
PG 12
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 902RM
UT WOS:000227374200005
DA 2026-07-24
ER

PT J
AU Buchanan, PJ
   Kung, TA
   Cederna, PS
AF Buchanan, Patrick J.
   Kung, Theodore A.
   Cederna, Paul S.
TI Evidence-Based Medicine: Wound Closure
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID FREE-TISSUE TRANSFER; VACUUM-ASSISTED CLOSURE; CIGARETTE-SMOKING;
   SKIN-GRAFTS; BACTERIAL INOCULATION; RECONSTRUCTIVE LADDER; PERFORATOR
   FLAP; BLOOD-FLOW; THERAPY; SURGERY
AB Learning Objectives: After reading this article, the participant should be able to: 1. Describe various wound closure techniques available to the modern plastic surgeon, including the indications and contraindications of each. 2. Explain the fundamental concepts of wound healing as it relates to reconstruction. 3. Understand the role of commonly used reconstructive adjuncts such as negative-pressure wound therapy, dermal substitutes, and tissue expansion. 4. Assess the important patient factors that may influence the strategy for surgical wound closure.
   Summary: Successful wound closure requires a comprehensive approach that includes consideration of suitable surgical techniques and critical patient factors. A clear understanding of key concepts such as wound healing, flap design, and patient risk assessment is imperative to a favorable outcome. In this Maintenance of Certification/Continuing Medical Education article, the reader is provided a summary of the available surgical options for wound closure and a discussion of the algorithm used to choose the most appropriate reconstructive strategy.
C1 [Buchanan, Patrick J.; Kung, Theodore A.; Cederna, Paul S.] Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Cederna, PS (通讯作者)，Univ Michigan Hlth Syst, Dept Surg, Sect Plast & Reconstruct Surg, 1500 East Med Ctr Dr 2130 Taubman Ctr,SPC 5340, Ann Arbor, MI 48109 USA.
EM cederna@med.umich.edu
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NR 95
TC 40
Z9 45
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD DEC
PY 2014
VL 134
IS 6
BP 1391
EP 1404
DI 10.1097/PRS.0000000000000720
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AU3WL
UT WOS:000345541400031
PM 25415102
DA 2026-07-24
ER

PT J
AU Lancerotto, L
   Bayer, LR
   Orgill, DP
AF Lancerotto, Luca
   Bayer, Lauren R.
   Orgill, Dennis P.
TI Mechanisms of action of microdeformational wound therapy
SO SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE Microdeformational wound therapy; Negative pressure; Wound therapy;
   NPWT; Microdeformation; Sub-atmospheric; Angiogenesis; Granulation;
   Foam; Dressing; Wound closure; Wound healing
ID VACUUM-ASSISTED CLOSURE; TOPICAL NEGATIVE-PRESSURE; IN-VIVO; SKIN;
   GROWTH; PROLIFERATION; EXPRESSION; MANAGEMENT; GRAFTS; TRAUMA
AB Microdeformational Wound Therapy (MDWT) is a class of medical devices that have revolutionized the treatment of complex wounds over the last 20 years. These devices, are a subset of Negative Pressure Wound Therapy (NPWT), in which there is a highly porous interface material placed between the wound and a semi-occlussive dressing and connected to suction. The porous interface material acts to deform the wound on a micro scale promoting cellular proliferation. These devices appear to significantly improve the speed of healing in many wounds, facilitate granulation tissue formation and reduce the complexity of subsequent reconstructive operations. The mechanisms through which such effects are obtained are beginning to be better understood through basic research and clinical trials. Further work in this field is likely to yield devices that are designed to treat specific wound types. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Lancerotto, Luca; Orgill, Dennis P.] Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, Boston, MA 02115 USA.
   [Lancerotto, Luca] Univ Padua, Inst Plast Reconstruct & Aesthet Surg, I-35100 Padua, Italy.
   [Lancerotto, Luca; Orgill, Dennis P.] Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of Padua; Harvard University; Harvard
   Medical School
RP Orgill, DP (通讯作者)，Brigham & Womens Hosp, Div Plast Surg, Tissue Engn & Wound Healing Lab, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI Lancerotto, Luca/A-5745-2013; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
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NR 66
TC 57
Z9 62
U1 0
U2 23
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1084-9521
J9 SEMIN CELL DEV BIOL
JI Semin. Cell Dev. Biol.
PD DEC
PY 2012
VL 23
IS 9
BP 987
EP 992
DI 10.1016/j.semcdb.2012.09.009
PG 6
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA 049DS
UT WOS:000311962800007
PM 23036531
DA 2026-07-24
ER

PT J
AU Sun, T
   Ying, WJ
   Wang, SS
   Chen, CQ
   Sun, PY
   Tan, JL
AF Sun, Tao
   Ying, Wenjie
   Wang, Shuangshuang
   Chen, Caiqiang
   Sun, Pengyu
   Tan, Jinglei
TI Clinical Application of Vacuum Sealing Drainage for the Treatment of
   Deep Burn Wounds
SO AMERICAN SURGEON
LA English
DT Article
DE vacuum sealing drainage; burn; deep burn; wound recovery; clinical
   effect
ID DIABETIC FOOT ULCERS; THERAPY; MANAGEMENT; TISSUE; DEBRIDEMENT;
   INFECTION
AB Background This study aimed to determine the effect of the clinical application of vacuum sealing drainage (VSD) on the treatment of deep burn wounds. Methods This single-blind, randomized, controlled study included patients who were admitted to our hospital with deep burns from January 2018 to December 2020; the patients were randomly divided into the VSD and control (CON) groups. The number of days from treatment to skin grafting; survival rate of the first skin graft; rate of positive bacterial culture; visual analog scale (VAS) pain score; and durations of wound healing, antibiotic drug use, and hospitalization were analyzed and compared between the groups. Results The application of VSD significantly shortened the number of days from treatment to skin grafting (P < .05); improved the survival rate of the first skin graft in patients with severe burns (P < .05); reduced the rate of positive bacterial culture (P < .05); reduced the VAS pain score (P < .05); and shortened the durations of wound healing (P < .05), antibiotic drug use (P < .05), and hospitalization (P < .05). Conclusion Vacuum sealing drainage had a good clinical effect on the recovery of deep burn wounds.
C1 [Sun, Tao; Ying, Wenjie; Wang, Shuangshuang; Chen, Caiqiang; Sun, Pengyu; Tan, Jinglei] First Peoples Hosp Wenling, Dept Burns & Plast Surg, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Peoples R China.
RP Tan, JL (通讯作者)，First Peoples Hosp Wenling, Dept Burns & Plast Surg, 333 Chuanan South Rd,Chengxi St, Wenling 317500, Peoples R China.
EM tanjinglei@21cn.com
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NR 24
TC 13
Z9 18
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD APR
PY 2023
VL 89
IS 4
BP 1018
EP 1023
AR 00031348211054527
DI 10.1177/00031348211054527
EA NOV 2021
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA J0VJ9
UT WOS:000721922400001
PM 34797180
DA 2026-07-24
ER

PT J
AU Liu, JY
   Chen, D
   Yin, XT
AF Liu, Jingyi
   Chen, Di
   Yin, Xiaoting
TI 被撤回的出版物: Effect of manual lymphatic drainage combined with vacuum
   sealing drainage on axillary web syndrome caused by breast cancer
   surgery (Retracted article. See vol. 22, 2025)
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article; Retracted Publication
DE axillary web syndrome; breast cancer; manual lymphatic drainage; vacuum
   sealing drainage
AB The aim of the study was to explore the application value of manual lymphatic drainage combined with vacuum sealing drainage in axillary web syndrome (AWS) after breast cancer surgery. From 1 April 2020 to 1 June 2020, a total of 102 patients with AWS after axillary lymph node biopsy or axillary lymph node dissection in our hospital were included in this prospective study. According to the random number table method, all patients were divided into the study group (n = 51) and the control group (n = 51). The study group received the treatment of manual lymphatic drainage combined with vacuum sealing drainage, and the control group received health education and the treatment of functional training. The efficacy observation indicators included duration time to the disappearance of relevant clinical symptoms, degree of pain, angle of abduction of the affected limb, degree of upper limb disability function and quality of life. The duration time to the disappearance of cord-like nodules and tightness in the study group was both significantly shorter than that in the control group (both P < .05). In the time point of 1 and 3 months after the intervention, compared with that in the control group, the study group had a significantly lighter degree of pain, a better degree of upper limb disability function and higher quality of life (all P < .05). Manual lymphatic drainage combined with vacuum sealing drainage can shorten the disappearance time of relevant clinical symptoms, relieve the degree of pain, improve the upper limb disability function and improve the quality of life in patients with AWS.
C1 [Liu, Jingyi; Chen, Di; Yin, Xiaoting] Huizhou Municipal Cent Peoples Hosp, Dept Breast Surg, 41 Eling North Rd, Huizhou 516001, Peoples R China.
RP Yin, XT (通讯作者)，Huizhou Municipal Cent Peoples Hosp, Dept Breast Surg, 41 Eling North Rd, Huizhou 516001, Peoples R China.
EM 42451691@qq.com
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NR 21
TC 5
Z9 8
U1 3
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JAN
PY 2023
VL 20
IS 1
BP 183
EP 190
DI 10.1111/iwj.13862
EA JUL 2022
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 7L0GY
UT WOS:000819661200001
PM 35778796
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Mody, GN
   Zurovcik, DR
   Joharifard, S
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   Mugenzi, D
   Riviello, R
AF Mody, Gita N.
   Zurovcik, Danielle R.
   Joharifard, Shahrzad
   Kansayisa, Grace
   Uwimana, Gemimah
   Baganizi, Erick
   Ntakiyiruta, Georges
   Mugenzi, Dominique
   Riviello, Robert
TI Biomechanical and Safety Testing of a Simplified Negative-Pressure Wound
   Therapy Device
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; CLOSURE; UPDATE
AB Background: There is a large, unmet need for acute and chronic wound care worldwide. Application of proven therapies such as negative-pressure wound therapy in resource-constrained settings is limited by cost and lack of electrical supply. To provide an alternative to existing electrically powered negative-pressure wound therapy systems, a bellows-powered negative-pressure wound therapy system was designed and iteratively improved during field-based testing. The authors describe the design process and the results of safety and biomechanical testing of their simplified negative-pressure wound therapy system.
   Methods: Simplified negative-pressure wound therapy was tested at two hospitals in Rwanda. Patients with wounds ranging from 2 to 150 cm(2) and meeting inclusion and exclusion criteria were enrolled. Wounds were categorized by difficulty of dressing application according to location and contour. Outcomes were maintenance of negative pressure and occurrence of adverse events.
   Results: Thirty-seven patients with 42 wounds were treated with simplified negative-pressure wound therapy. Eighty-five dressings in total were applied. On average, the final simplified negative-pressure wound therapy dressing maintained negative pressure for 31.7 hours on all wounds (n = 37), and 52.7 hours on wounds in easy-to-dress locations. No unexpected adverse events occurred.
   Conclusions: This is the first systematic report of the performance of a bellows-powered negative-pressure wound therapy device designed specifically for use in resource-constrained settings. The authors found that elimination of air leaks in the simplified negative-pressure wound therapy dressing is essential, and that their system is safe and feasible for use in these environments. Subsequent trials will study the system's efficacy.
C1 [Mody, Gita N.] Brigham & Womens Hosp, Ctr Surg & Publ Hlth, Dept Gen Surg, Boston, MA 02115 USA.
   Worldwide Innovat Healthcare Inc, Boston, MA USA.
   Univ British Columbia, Dept Surg, Vancouver, BC V5Z 1M9, Canada.
   Natl Univ Rwanda, Butaro, Rwanda.
   Rwinkwavu Hosp, Dept Nursing, Butaro, Rwanda.
   Drew Cares Int, Kigali, Rwanda.
   Natl Univ Rwanda, Kigali Univ Teaching Hospital, Dept Surg, Butare, Rwanda.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of British Columbia; University of Rwanda;
   University of Rwanda
RP Mody, GN (通讯作者)，Brigham & Womens Hosp, Ctr Surg & Publ Hlth, Dept Gen Surg, 75 Francis St, Boston, MA 02115 USA.
EM gmody@partners.org
RI ; Mody, Gita/KQV-0468-2024
OI Joharifard, Shahrzad/0000-0002-0202-8758; Mody, Gita/0000-0003-0218-6948
FU Fogarty International Clinical Research Fellowship; Vanderbilt
   University [R24 TW007988]; Hugh Hampton Young Memorial Fund Fellowship;
   Massachusetts Institute of Technology Legatum Center
FX The authors would like to acknowledge the Fogarty International Clinical
   Research Fellowship, the National Institutes for Health and
   International Clinical Research Fellows Program at Vanderbilt University
   (R24 TW007988), the Hugh Hampton Young Memorial Fund Fellowship, and the
   Massachusetts Institute of Technology Legatum Center for financial
   support of the project. They would like to thank the Ministry of Health
   of Rwanda for promoting a culture of innovation and equity in patient
   care. Lastly, they would like to acknowledge the staff at Rwinkwavu
   Hospital, Inshuti Mu Buzima/Partners In Health, and Kigali University
   Teaching Hospital for their collaboration and support and their
   commitment to improving patient care on a daily basis.
CR Armstrong DG, 2011, PLAST RECONSTR SURG, V127, p116S, DOI 10.1097/PRS.0b013e3181fb5431
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Braakenburg A, 2006, PLAST RECONSTR SURG, V118, P390, DOI 10.1097/01.prs.0000227675.63744.af
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Flack S, 2008, J Wound Care, V17, P71
   Fong KD, 2010, PLAST RECONSTR SURG, V125, P1362, DOI 10.1097/PRS.0b013e3181d62b25
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   Mouës CM, 2011, AM J SURG, V201, P544, DOI 10.1016/j.amjsurg.2010.04.029
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   Zurovcik D, 2007, DEV SIMPLIFIED NEGAT
NR 17
TC 5
Z9 7
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD APR
PY 2015
VL 135
IS 4
BP 1140
EP 1146
DI 10.1097/PRS.0000000000001101
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE5XU
UT WOS:000351910200053
PM 25502858
DA 2026-07-24
ER

PT J
AU Choi, SI
   Park, JC
   Lee, JE
   Kim, EH
   Shin, SK
   Lee, SK
   Lee, YC
AF Choi, Soo In
   Park, Jun Chul
   Lee, Jeung Eun
   Kim, Eun Hye
   Shin, Sung Kwan
   Lee, Sang Kil
   Lee, Yong Chan
TI Efficacy of endoscopic vacuum assisted closure treatment for
   post-gastrectomy anastomotic leakage
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Meeting Abstract
DE anastomotic leakage; endoscopic vacuum assisted closure; gastrectomy
C1 [Choi, Soo In; Park, Jun Chul; Lee, Jeung Eun; Kim, Eun Hye; Shin, Sung Kwan; Lee, Sang Kil; Lee, Yong Chan] Severance Hosp, Dept Internal Med GI Hepatol, Seoul, South Korea.
C3 Yonsei University; Severance Hospital
RI Park, Jun/H-7218-2019
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD NOV
PY 2018
VL 33
SU 4
SI SI
MA EE-0397 (P
BP 298
EP 298
PG 1
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HA4UR
UT WOS:000450260401153
DA 2026-07-24
ER

PT J
AU Kim, P
AF Kim, Paul
TI Negative Pressure Wound Therapy With Instillation: An Adjunctive Therapy
   for Infection Management in Orthopaedic Trauma
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE negative pressure wound therapy with instillation; NPWTi-d; negative
   pressure wound therapy; NPWT; infection; bacteria; orthopaedic trauma;
   antimicrobial; antiseptic; wound; biofilm; irrigation
ID SURGICAL SITE INFECTION; RISK-FACTORS; BIOBURDEN; FIXATION; STANDARD;
   SALINE
AB Negative Pressure Wound Therapy with Instillation is a device that provides the benefits of standard negative pressure wound therapy and instillation of a topical wound solution. This combination can benefit acute and chronic wounds by continuously cleansing the wound and providing soft tissue stability between staged operations or in preparation for a single procedure. Although skeletal stability is important in orthopaedic trauma, the overlying soft tissue envelop may also be compromised, which can lead to contamination and infection. This review will discuss the growing body of evidence for the use of negative pressure wound therapy with instillation with a focus on infection and recommendations for its proper use.
C1 [Kim, Paul] Univ Texas Southwestern, Dept Plast Surg, Dallas, TX 75390 USA.
   [Kim, Paul] Univ Texas Southwestern, Dept Orthoped Surg, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center; University of Texas System; University of Texas Southwestern
   Medical Center
RP Kim, P (通讯作者)，Univ Texas Southwestern, Dept Plast Surg, Dallas, TX 75390 USA.; Kim, P (通讯作者)，Univ Texas Southwestern, Dept Orthoped Surg, Dallas, TX 75390 USA.
OI , Paul/0000-0002-6186-6890
CR Brinkert D, 2013, INT WOUND J, V10, P56, DOI 10.1111/iwj.12176
   Davis K, 2013, WOUND REPAIR REGEN, V21, P869, DOI 10.1111/wrr.12104
   Diehm YF, 2021, PLAST RECONSTR SURG, V147, p43S, DOI 10.1097/PRS.0000000000007610
   Gabriel A, 2021, PLAST RECONSTR SURG, V147, p68S, DOI 10.1097/PRS.0000000000007614
   Gabriel Allen, 2014, Surg Technol Int, V24, P75
   Goss S G, 2012, J Am Coll Clin Wound Spec, V4, P74, DOI 10.1016/j.jccw.2014.02.001
   Henkelmann R, 2017, BMC MUSCULOSKEL DIS, V18, DOI 10.1186/s12891-017-1847-z
   Hübner NO, 2010, SKIN PHARMACOL PHYS, V23, P17, DOI 10.1159/000318264
   Kim PJ, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9047
   Kim PJ, 2020, INT WOUND J, V17, P1194, DOI 10.1111/iwj.13424
   Kim PJ, 2020, INT WOUND J, V17, P174, DOI 10.1111/iwj.13254
   Kim PJ, 2018, WOUNDS, pS1
   Kim PJ, 2015, PLAST RECONSTR SURG, V136, p657E, DOI 10.1097/PRS.0000000000001709
   Kim PJ, 2014, PLAST RECONSTR SURG, V133, P709, DOI 10.1097/01.prs.0000438060.46290.7a
   Kim PJ, 2013, PLAST RECONSTR SURG, V132, P1569, DOI 10.1097/PRS.0b013e3182a80586
   Kim PJ, 2015, Wounds, V27, pS2
   Liu J, 2021, PLAST RECONSTR SURG, V147, p54S, DOI 10.1097/PRS.0000000000007622
   McKanna M, 2016, OSTOMY WOUND MANAG, P3
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Phillips PL, 2013, INT WOUND J, V10, P48, DOI 10.1111/iwj.12180
   Shao JS, 2018, INT J SURG, V56, P124, DOI 10.1016/j.ijsu.2018.06.018
   Shao JS, 2017, INT J SURG, V41, P176, DOI 10.1016/j.ijsu.2017.03.085
   Streubel PN, 2012, J AM ACAD ORTHOP SUR, V20, P564, DOI 10.5435/JAAOS-20-09-564
   Yang C, 2017, WOUNDS, V29, P240
NR 25
TC 1
Z9 2
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD SEP
PY 2022
VL 36
SU 4
BP S12
EP S16
DI 10.1097/BOT.0000000000002428
PG 5
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA 3Y2NF
UT WOS:000843564400004
PM 35994303
DA 2026-07-24
ER

PT J
AU Stainier, A
   Tombal, B
   Di Gregorio, M
   Van Cauwenberghe, G
   Querton, M
   Fosseprez, P
   Lorge, F
AF Stainier, Annabelle
   Tombal, Bertrand
   Di Gregorio, Marcelo
   Van Cauwenberghe, Gilles
   Querton, Michael
   Fosseprez, Philippe
   Lorge, Francis
TI Fournier's gangrene on ischial pressure ulcer : use of vacuum-assisted
   closure and therapeutic strategy
SO PROGRES EN UROLOGIE
LA French
DT Article
DE Fournier's gangrene; vacuum-assisted closure; reconstruction
AB Vacuum-assisted closure (V.A.C.) was used in two paraplegic patients with Fournier's gangrene in a context of ischial pressure ulcer. This type of dressing facilitated preparation of reconstruction.
C1 UCL Mt Godinne, Serv Urol, Yvoir, Belgium.
   UCL St Luc, Serv Urol, Brussels, Belgium.
   UCL Mt Godinne, Serv Chirurg Plast, Yvoir, Belgium.
C3 Universite Catholique Louvain; Universite Catholique Louvain Hospital;
   Universite Catholique Louvain; Universite Catholique Louvain; Universite
   Catholique Louvain Hospital
RP Stainier, A (通讯作者)，Ave G Therasse 1, B-5530 Yvoir, Belgium.
EM Annabelle.Stainier@mont.ucl.ac.be
OI TOMBAL, Bertrand/0000-0002-0093-8408
CR Bickels J, 2005, CLIN ORTHOP RELAT R, P346, DOI 10.1097/01.blo.0000180450.21350.3e
   Cannistra C, 2003, PROG UROL, V13, P703
   Demaria RG, 2003, HEART SURG FORUM, V6, P434
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   Tahmaz L, 2006, INT J UROL, V13, P960, DOI 10.1111/j.1442-2042.2006.01448.x
NR 5
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1166-7087
EI 2405-5131
J9 PROG UROL
JI Prog. Urol.
PD SEP
PY 2007
VL 17
IS 5
BP 1000
EP 1002
DI 10.1016/S1166-7087(07)92407-0
PG 3
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 215JJ
UT WOS:000249804300022
PM 17969807
DA 2026-07-24
ER

PT J
AU Yuan, YK
   Wang, JJ
   Guan, JW
AF Yuan, Yikai
   Wang, Junjie
   Guan, Junwen
TI Negative pressure wound therapy to manage peri-implant infections after
   cranioplasty: A case report
SO ASIAN JOURNAL OF SURGERY
LA English
DT Letter
DE Cranioplasty; Negative pressure wound therapy; Debridement
ID COMPLICATIONS
C1 [Yuan, Yikai; Wang, Junjie; Guan, Junwen] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University
RP Guan, JW (通讯作者)，Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China.
EM 3751644784@qq.com
CR Kim H, 2013, ACTA NEUROCHIR, V155, P2171, DOI 10.1007/s00701-013-1877-8
   Normandin S, 2021, SEMIN PLAST SURG, V35, P164, DOI 10.1055/s-0041-1731792
   Paredes I, 2015, NEUROCIRUGIA, V26, P115, DOI 10.1016/j.neucir.2014.10.001
   Zanaty M, 2015, J NEUROSURG, V123, P182, DOI 10.3171/2014.9.JNS14405
   Zanaty Mario, 2014, ScientificWorldJournal, V2014, P356042, DOI 10.1155/2014/356042
NR 5
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD FEB
PY 2026
VL 49
IS 2
BP 1047
EP 1048
DI 10.1016/j.asjsur.2025.07.292
EA FEB 2026
PG 2
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DJ5RP
UT WOS:001684946000001
OA gold
DA 2026-07-24
ER

PT J
AU Lynch, JB
   Laing, AJ
   Regan, PJ
AF Lynch, JB
   Laing, AJ
   Regan, PJ
TI Vacuum-assisted closure therapy: A new treatment option for recurrent
   pilonidal sinus disease. Report of three cases
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE pilonidal sinus disease; vacuum-assisted closure
ID FLAP; EXPERIENCE; EXCISION
AB No single treatment option available for symptomatic pilonidal disease is entirely satisfactory. In our department, we have treated successfully three cases of pilonidal disease with vacuum-assisted closure therapy. We describe our initial experience with this technique. In two cases, the pilonidal sinus was primarily excised, a split skin graft applied to cover the defect, and the vacuum-assisted closure pump applied over the skin graft for a period of four days on a continuous negative pressure of 50 mmHg. The third case was treated and completely healed with vacuum-assisted closure therapy alone. To our knowledge, this is the first report in the literature describing the use of vacuum-assisted closure therapy for this condition. We propose this therapy as an alternative adjunctive treatment for pilonidal disease.
C1 Univ Coll Hosp Galway, Dept Plast Reconstruct & Hand Surg, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway
EM jennylynch@oceanfree.net
CR ALLENMERSH TG, 1990, BRIT J SURG, V77, P123, DOI 10.1002/bjs.1800770203
   ALSPAUGH D, 2001, PROB GEN SURG, V18, P45
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Dylek ON, 1998, EUR J SURG, V164, P961
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   Mayo H., 1833, OBSERVATIONS INJURIE
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NR 15
TC 29
Z9 39
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0012-3706
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD JUN
PY 2004
VL 47
IS 6
BP 929
EP 932
DI 10.1007/s10350-004-0522-2
PG 4
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 825RV
UT WOS:000221776900023
PM 15129309
DA 2026-07-24
ER

PT J
AU Scherer, SS
   Pietramaggiori, G
   Mathews, JC
   Prsa, MJ
   Huang, S
   Orgill, DP
AF Scherer, Sandra Saja
   Pietramaggiori, Giorgio
   Mathews, Jasmine C.
   Prsa, Michael J.
   Huang, Sui
   Orgill, Dennis P.
TI The mechanism of action of the vacuum-assisted closure device
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID WOUND THERAPY; CLINICAL-EXPERIENCE; CELL-PROLIFERATION; FOOT ULCERS;
   ANGIOGENESIS; PRESSURE; MATRIX; SKIN
AB Background: The vacuum-assisted closure device is widely used clinically, yet its mechanisms of action are incompletely understood. In this study, the authors designed a partially splinted full-thickness murine vacuum-assisted closure model to better understand the mechanism of action of the vacuum-assisted closure device.
   Methods: Full-thickness wounds (n = 1.0 per group) were excised in diabetic mice and treated with the vacuum-assisted closure device or its isolated components: an occlusive dressing, subatmospheric pressure at 125 mmHg (suction), and a polyurethane foam without and with downward compression. Results were quantified with a two-dimensional immunohistochemical staging system based on blood vessel density (CD31) and cell proliferation (Ki67) 7 days after wounding. Microscopic strain was measured by fixing in situ all dressing modalities.
   Results: Wounds exposed to polyurethane foam in compressed and uncompressed dressings or to the vacuum-assisted closure device showed a 2-fold increase in vascularity compared with the occlusive dressing group (p < 0.05). The vacuum-assisted closure device in addition stimulated cell proliferation, with Lip to 82 percent Ki67-positive nuclei, compared with the other groups. Direct measurements of wound surface deformations showed significant microstrains in the vacuum-assisted closure and foam in compressed dressing groups (60 percent and 16 percent, respectively) compared with all other groups.
   Conclusions: These data provide profound insights into the mechanism of action of the vacuum-assisted closure device, providing an explanation for the increases in wound bed vascularity and cell proliferation based on its components. Results suggest that the vascular response is related to the polyurethane foam, whereas tissue strains induced by the vacuum-assisted closure device Stimulated cell proliferation.
C1 [Orgill, Dennis P.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Childrens Hosp, Dept Pathol & Surg, Boston, MA 02115 USA.
   Heidelberg Univ, BG Unfallklin Ludwigshafen, Div Plast & Reconstruct Surg, D-6900 Heidelberg, Germany.
   Univ Geneva, Div Plast Surg, CH-1211 Geneva 4, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; Ruprecht Karls University Heidelberg; University of
   Geneva
RP Orgill, DP (通讯作者)，Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA.
EM dorgill@partners.org
RI PIETRAMAGGIORI, Giorgio/HJA-1920-2022; Orgill, Dennis/H-7596-2019
OI Orgill, Dennis/0000-0002-8279-7310
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
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   MARKS MW, 1987, CLIN PLAST SURG, V14, P455
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   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
   Orgill DP, 2004, WOUNDS, p15S
   Orgill DP, 2004, WOUNDS, P1
   Pietramaggiori G, 2007, ANN SURG, V246, P896, DOI 10.1097/SLA.0b013e3180caa47f
   Pietramaggiori G, 2007, WOUND REPAIR REGEN, V15, P213, DOI 10.1111/j.1524-475X.2007.00207.x
   Pietramaggiori G, 2006, WOUND REPAIR REGEN, V14, P573, DOI 10.1111/j.1743-6109.2006.00164.x
   Saldalamacchia G, 2004, NUTR METAB CARDIOVAS, V14, P395, DOI 10.1016/S0939-4753(04)80029-2
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   Singh N, 2005, JAMA-J AM MED ASSOC, V293, P217, DOI 10.1001/jama.293.2.217
NR 19
TC 236
Z9 304
U1 1
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD SEP
PY 2008
VL 122
IS 3
BP 786
EP 797
DI 10.1097/PRS.0b013e31818237ac
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 345KW
UT WOS:000258996700014
PM 18766042
DA 2026-07-24
ER

PT J
AU Krueger, T
   Perentes, JY
   Ris, HB
   Gonzalez, M
AF Krueger, Thorsten
   Perentes, Jean Yannis
   Ris, Hans-Beat
   Gonzalez, Michel
TI The intrathoracic vacuum-assisted closure device in case of
   post-pneumonectomy empyema
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Letter
DE Vacuum-assisted closure; Pneumonectomy; Empyema; Broncho-pleural fistula
C1 [Krueger, Thorsten; Perentes, Jean Yannis; Ris, Hans-Beat; Gonzalez, Michel] CHU Vaudois, Div Thorac Surg, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Krueger, T (通讯作者)，CHU Vaudois, Dept Thorac & Vasc Surg, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM thorsten.krueger@chuv.ch
RI ; Krueger, Thorsten/AAK-1780-2021
OI Perentes, Jean/0000-0001-7918-0793; gonzalez,
   michel/0000-0001-8705-4279; 
CR Rocco G, 2012, EUR J CARDIO-THORAC, V41, P1069, DOI 10.1093/ejcts/ezr196
   Saadi A, 2011, ANN THORAC SURG, V91, P1582, DOI 10.1016/j.athoracsur.2011.01.018
NR 2
TC 1
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2013
VL 43
IS 5
BP 1077
EP 1077
DI 10.1093/ejcts/ezs577
PG 1
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 132VS
UT WOS:000318097400052
PM 23152435
OA Green Submitted, Green Published, Bronze
DA 2026-07-24
ER

PT J
AU Mees, ST
   Palmes, D
   Mennigen, R
   Senninger, N
   Haier, J
   Bruewer, M
AF Mees, Soeren Torge
   Palmes, Daniel
   Mennigen, Rudolf
   Senninger, Norbert
   Haier, Joerg
   Bruewer, Matthias
TI Endo-vacuum assisted closure treatment for rectal anastomotic
   insufficiency
SO DISEASES OF THE COLON & RECTUM
LA English
DT Article
DE anastomotic leakage; vacuum assisted closure; rectal surgery; wound
   healing
ID RISK-FACTORS; MESORECTAL EXCISION; WOUND CONTROL; RESECTION; DRAINAGE;
   LEAKAGE; CANCER
AB BACKGROUND: Anastomotic insufficiency in patients with colorectal anastomosis is a major complication with high morbidity and mortality. Local treatment with transrectal lavage and drainage can be considered in patient without peritonitis. In order to prevent prolonged wound closure and secondary complications during conservative treatment we investigated the vacuum assisted closure (VAC) in this setting.
   METHODS: Ten patients with anastomotic insufficiency after colorectal resections, who did not require transabdominal interventions, were treated with an Endo-vacuum assisted closure dressing (Group A; n=5) or by transrectal lavage (Group B; n=5). Time for wound healing, duration of hospitalization and pain assessment were compared in both groups.
   RESULTS: The Endo-vacuum assisted closure treatment was performed for a median time of 27 days without any vacuum assisted closure associated complications. Wound healing was significantly accelerated in Group A compared to Group B. Time in hospital was slightly shortened in patients with Endo-vacuum assisted closure. Pain assessment in both groups did not show any significant differences.
   CONCLUSION: Endo-vacuum assisted closure therapy is a novel approach that can be considered in diverted patients with failed colorectal anastomoses. Larger randomized trials that include complete cost-benefit analyses are needed to establish its role in this setting.
C1 [Mees, Soeren Torge; Palmes, Daniel; Mennigen, Rudolf; Senninger, Norbert; Haier, Joerg; Bruewer, Matthias] Univ Hosp Muenster, Dept Gen Surg, D-48149 Munster, Germany.
C3 University of Munster
RP Mees, ST (通讯作者)，Univ Hosp Muenster, Dept Gen Surg, Waldeyerstr 1, D-48149 Munster, Germany.
EM soerentorge.mees@ukmuenster.de
RI Haier, Jörg/JJF-6724-2023
OI Haier, Jörg/0000-0002-1278-9438
CR Anderson ID, 1996, BRIT J SURG, V83, P535, DOI 10.1002/bjs.1800830434
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Argenta LC, 2006, PLAST RECONSTR SURG, V117, p127S, DOI 10.1097/01.prs.0000222551.10793.51
   Armstrong DG, 2005, LANCET, V366, P1704, DOI 10.1016/S0140-6736(05)67695-7
   Averbach AM, 1996, DIS COLON RECTUM, V39, P780, DOI 10.1007/BF02054444
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Karliczek A, 2006, COLORECTAL DIS, V8, P259, DOI 10.1111/j.1463-1318.2006.00999.x
   Keighley MRB, 1993, SURG ANUS RECTUM COL, P1024
   Labler L, 2007, LANGENBECK ARCH SURG, V392, P601, DOI 10.1007/s00423-006-0090-0
   Law WL, 2000, AM J SURG, V179, P92, DOI 10.1016/S0002-9610(00)00252-X
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Nagell CF, 2006, INT J COLORECTAL DIS, V31, P1
   Nesbakken A, 2005, COLORECTAL DIS, V7, P576, DOI 10.1111/j.1463-1318.2005.00870.x
   Peeters KCMJ, 2005, BJS-BRIT J SURG, V92, P211, DOI 10.1002/bjs.4806
   Rullier E, 1998, BRIT J SURG, V85, P355
   Schaffzin DM, 2004, DIS COLON RECTUM, V47, P1745, DOI 10.1007/s10350-004-0633-9
   Tonus C, 1996, LANGENBECK ARCH CHIR, V381, P251
   Urbach DR, 1999, ANN SURG, V229, P174, DOI 10.1097/00000658-199902000-00003
   Weidenhagen R, 2006, ZBL CHIR, V131, pS115, DOI 10.1055/s-2006-921512
   WEIDENHAGEN R, 2003, INT J COLORECTAL DIS, V5, P1
NR 20
TC 64
Z9 76
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0012-3706
EI 1530-0358
J9 DIS COLON RECTUM
JI Dis. Colon Rectum
PD APR
PY 2008
VL 51
IS 4
BP 404
EP 410
DI 10.1007/s10350-007-9141-z
PG 7
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 277SP
UT WOS:000254235300008
PM 18197452
DA 2026-07-24
ER

PT J
AU Aydin, S
   Temur, B
   Suzan, D
   Kirat, B
   Demir, IH
   Özen, M
   Erek, E
AF Aydin, Selim
   Temur, Bahar
   Suzan, Dilek
   Kirat, Baris
   Demir, Ibrahim Halil
   Ozen, Metehan
   Erek, Ersin
TI Mediastinal vacuum-assisted closure therapy following pediatric
   congenital cardiac surgery
SO TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND
   CARDIOVASCULAR SURGERY
LA Turkish
DT Article
DE Congenital heart surgery; mediastinitis; newborn; sternum;
   vacuum-assisted closure
ID WOUND CONTROL; INFECTIONS; EXPERIENCE; CHILDREN; PATIENT
AB Background: In this study, we report nine pediatric cases who developed sternal wound complications following complex congenital cardiac surgery and treated with mediastinal vacuum-assisted closure technique.
   Methods: Between January 2014 and December 2015, a total of 473 congenital heart operations were performed in our hospital. Of these patients, nine (8 males, 1 females; median age 24 days; range 15 days to 14 months) underwent mediastinal vacuum-assisted closure therapy. The indication of vacuum-assisted closure therapy was mediastinitis in five patients and sternal wound complications in four patients.
   Results: Sternum was left open in four patients after the initial operation. The median time from opening sternum to vacuum-assisted closure therapy was 10 days (range, 7 to 15 days) in these patients. Indications were positive mediastinal cultures in three patients and intolerance for sternal closure due to ventricular dysfunction and cardiac edema in one patient. In the remaining five patients, sternal wound complications developed later and vacuum-assisted closure therapy was applied after a median of 19 days (range, 11 to 36 days) after the operation. Mediastinal cultures were positive in two patients. Two patients (22%) died of sepsis and multi-organ failure. In the remaining patients, sternal wounds were closed within seven days (range, 5 to 19 days), when sternal cultures were negative or good granulation was obtained. Recurrent sternal wound complication developed in one patient (14.2%) and vacuum-assisted closure therapy was repeated. All patients, except two, underwent vacuum-assisted closure therapy in the intensive care unit.
   Conclusion: Mediastinal vacuum-assisted closure therapy is a good option in children with sternal wound complications after cardiac surgery. In addition, it may accelerate the healing process and reduce medical resource use.
C1 [Aydin, Selim; Temur, Bahar; Suzan, Dilek; Erek, Ersin] Acibadem Univ, Atakent Hastanesi, Kalp & Damar Cerrahisi Bolumu, TR-34303 Istanbul, Turkey.
   [Kirat, Baris] Acibadem Univ, Atakent Hastanesi, Anesteziyoloji & Reanimasyon Bolumu, Istanbul, Turkey.
   [Demir, Ibrahim Halil] Acibadem Univ, Atakent Hastanesi, Cocuk Kardiyolojisi Bolumu, Istanbul, Turkey.
   [Ozen, Metehan] Acibadem Univ, Atakent Hastanesi, Cocuk Enfeksiyon Hastaliklari Bolumu, Istanbul, Turkey.
C3 Acibadem University; Acibadem University; Acibadem University; Acibadem
   University
RP Aydin, S (通讯作者)，Acibadem Univ, Atakent Hastanesi, Kalp & Damar Cerrahisi Bolumu, TR-34303 Istanbul, Turkey.
EM draydinselim@yahoo.com
RI demir, ibrahim halil/HKV-0784-2023; Aydin, Selim/MZQ-4617-2025; Ozen,
   Metehan/X-2705-2018; /W-8135-2018
OI demir, ibrahim halil/0000-0002-9079-9818; Aydin,
   Selim/0000-0003-2708-2125; Ozen, Metehan/0000-0003-4088-3103; 
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Erek E, 2012, WORLD J PEDIATR CONG, V3, P229, DOI 10.1177/2150135111432771
   Erez E, 2000, ANN THORAC SURG, V69, P572, DOI 10.1016/S0003-4975(99)01075-9
   Fleck Tatjana, 2006, Interact Cardiovasc Thorac Surg, V5, P285, DOI 10.1510/icvts.2005.122424
   Fleck TM, 2002, ANN THORAC SURG, V74, P1596, DOI 10.1016/S0003-4975(02)03948-6
   Gummert JF, 2002, THORAC CARDIOV SURG, V50, P87, DOI 10.1055/s-2002-26691
   Mehta PA, 2000, PEDIATR INFECT DIS J, V19, P1000, DOI 10.1097/00006454-200010000-00012
   Mokhtari A, 2006, ANN THORAC SURG, V82, P1063, DOI 10.1016/j.athoracsur.2006.04.085
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Ohye RG, 2004, J THORAC CARDIOV SUR, V128, P480, DOI 10.1016/j.jtcvs.2004.04.023
   Ramnarine IR, 2002, EUR J CARDIO-THORAC, V22, P1029, DOI 10.1016/S1010-7940(02)00562-6
   Salazard B, 2008, J PLAST RECONSTR AES, V61, P302, DOI 10.1016/j.bjps.2007.05.004
   Sjogren Johan, 2004, Interact Cardiovasc Thorac Surg, V3, P666, DOI 10.1016/j.icvts.2004.08.003
   Tatar T, 2012, TURK GOGUS KALP DAMA, V20, P256, DOI 10.5606/tgkdc.dergisi.2012.049
   Tortoriello TA, 2003, ANN THORAC SURG, V76, P1655, DOI 10.1016/S0003-4975(03)01025-7
NR 15
TC 1
Z9 1
U1 0
U2 3
PU BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
PI ATASEHIR
PA ORNEK MH DR SUPHI EZGI SK SARAY APT NO 11 D 6, ATASEHIR, ISTANBUL 34704,
   TURKEY
SN 1301-5680
J9 TURK GOGUS KALP DAMA
JI Turk Gogus Kalp Damar Cerrahisi Derg.
PD APR
PY 2017
VL 25
IS 2
BP 174
EP 179
DI 10.5606/tgkdc.dergisi.2017.13820
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EW6KX
UT WOS:000402620300002
OA hybrid
DA 2026-07-24
ER

PT J
AU Deng, KX
   Yuan, ZG
   Li, D
AF Deng, Kexin
   Yuan, Zhigen
   Li, Dian
TI Academic visualization and trend analysis of negative-pressure wound
   therapy from a global perspective
SO ASIAN JOURNAL OF SURGERY
LA English
DT Letter
DE Bibliometrics; Wound; Negative pressure wound therapy; Citespace;
   Reconstruction
C1 [Deng, Kexin; Yuan, Zhigen] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Orthopaed, 427 Furong Middle Rd, Changsha 410007, Hunan, Peoples R China.
   [Deng, Kexin] Cent South Univ, Xiangya Hosp 3, Dept Plast & Reconstruct, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
   [Li, Dian] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
C3 Central South University; University of California System; University of
   California Los Angeles
RP Yuan, ZG (通讯作者)，Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Orthopaed, 427 Furong Middle Rd, Changsha 410007, Hunan, Peoples R China.; Li, D (通讯作者)，Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
EM 411873324@qq.com; ldmph2023@g.ucla.edu
RI ; Yuan, Zhigen/ACF-9098-2022
OI Li, Dian/0009-0005-4067-9964; 
CR Agarwal Pawan, 2019, J Clin Orthop Trauma, V10, P845, DOI [10.1016/j.jcot.2019.06.015, 10.1016/j.jcot.2019.06.015]
   Bhardwaj H, 2026, INT J LOW EXTR WOUND, V25, P284, DOI 10.1177/15347346241228788
   Huang CY, 2014, CURR PROB SURG, V51, P301, DOI 10.1067/j.cpsurg.2014.04.001
   Normandin S, 2021, SEMIN PLAST SURG, V35, P164, DOI 10.1055/s-0041-1731792
NR 4
TC 0
Z9 0
U1 2
U2 23
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1015-9584
EI 0219-3108
J9 ASIAN J SURG
JI Asian J. Surg.
PD OCT
PY 2024
VL 47
IS 10
BP 4449
EP 4451
DI 10.1016/j.asjsur.2024.07.188
EA SEP 2024
PG 3
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA I1L1I
UT WOS:001327931800001
PM 39127515
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Luckraz, H
   Murphy, F
   Bryant, S
   Charman, SC
   Ritchie, AJ
AF Luckraz, H
   Murphy, F
   Bryant, S
   Charman, SC
   Ritchie, AJ
TI Vacuum-assisted closure as a treatment modality for infections after
   cardiac surgery
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID POSTSTERNOTOMY MEDIASTINITIS; MANAGEMENT
AB Objective: Wound infections after cardiac surgery carry high morbidity and mortality. A plethora of management strategies have been used to treat such infections. We assessed the impact of vacuum-assisted closure on the management of sternal wound infections in terms of wound healing, duration of vacuum-assisted closure, and cost of treatment.
   Methods: Between November 1998 and June 2001, a total of 27 mediastinal infections were managed with vacuum-assisted closure. Group A (n = 14) had vacuum-assisted closure as the final treatment modality, whereas in group B (n = 13) vacuum-assisted closure was followed by either a myocutaneous flap (n = 8) or primary (n = 5) wound closure. The choice of additional treatment modality was based on wound size.
   Results: In group A, 4 patients died and a satisfactorily healed sear was achieved in 64% of cases. Median durations of vacuum-assisted closure and hospital stay in group A were 13.5 days (interquartile range 8.8-32.2 days) and 20 days (interquartile range 16.7-25.2 days), respectively. Mortality was 7.7% in group B, with a treatment failure rate of 15%. Median duration of vacuum-assisted closure in group B was 8 days (interquartile range 5.5-18 days), and median hospital stay was 29 days (interquartile range 25.8-38.2 days). During the year before institution of vacuum-assisted closure, poststernotomy infection (n = 13) was managed with rewiring and closed irrigation system. Treatment during this year failed in 30.7% of cases (n = 4/13), and mortality was also 30.7%. The total cost (hospitalization and treatment) per patient for vacuum-assisted closure was $16,400, compared with $20,000 for the closed irrigation system treatment.
   Conclusion: Vacuum-assisted closure, used alone or before other surgical treatment strategies, is an acceptable treatment modality for infections in cardiac surgery with reasonable morbidity, mortality, and cost.
C1 Papworth Hosp, Cardiothorac Surg Unit, Cambridge CB3 8RE, England.
   MRC, Biostat Unit, Cambridge CB2 2BW, England.
C3 Papworth Hospital; MRC Biostatistics Unit
RP Luckraz, H (通讯作者)，Papworth Hosp, Cardiothorac Surg Unit, Cambridge CB3 8RE, England.
RI ; Luckraz, Heyman/AAV-7206-2020
OI Downie, Fiona/0009-0008-5892-3648; Luckraz, Heyman/0000-0003-1218-1243
CR Banwell P E, 1999, J Wound Care, V8, P79
   Bucalo Brian, 1993, Wound Repair and Regeneration, V1, P181, DOI 10.1046/j.1524-475X.1993.10308.x
   Catarino PA, 2000, ANN THORAC SURG, V70, P1891, DOI 10.1016/S0003-4975(00)02173-1
   Davydov Iu A, 1992, Khirurgiia (Mosk), P21
   ElOakley RM, 1996, ANN THORAC SURG, V61, P1030, DOI 10.1016/0003-4975(95)01035-1
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   GIBSON T, 1977, RECONSTRUCTIVE SURG, V1
   LOOP FD, 1990, ANN THORAC SURG, V49, P179, DOI 10.1016/0003-4975(90)90136-T
   LUCKRAZ H, 1996, CURR OPIN SURG INFEC, V4, P1
   Milton H., 1987, Lancet, V1, P872, DOI [DOI 10.1016/S0140-6736(01)96474-8, 10.1016/S0140-6736(01)96474-8]
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Obdeijn MC, 1999, ANN THORAC SURG, V68, P2358, DOI 10.1016/S0003-4975(99)01159-5
   Tang ATM, 2000, EUR J CARDIO-THORAC, V17, P482, DOI 10.1016/S1010-7940(00)00349-3
NR 13
TC 77
Z9 89
U1 0
U2 4
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0022-5223
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD FEB
PY 2003
VL 125
IS 2
BP 301
EP 305
DI 10.1067/mtc.2003.74
PG 5
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 647NY
UT WOS:000181100800011
PM 12579098
OA Bronze
DA 2026-07-24
ER

PT J
AU Karoo, ROS
   Shariff, Z
   Stanley, PRW
AF Karoo, R. O. S.
   Shariff, Z.
   Stanley, P. R. W.
TI DuoDERM strip border - A new technique for Vacuum-assisted closure in
   complex facial wounds
SO BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
LA English
DT Article
DE Vacuum Assisted Closure; Facial Wounds; Duoderm; VAC
C1 [Karoo, R. O. S.; Shariff, Z.; Stanley, P. R. W.] Castle Hill Hosp, Kingston Upon Hull, N Humberside, England.
C3 University of Hull
EM richardkaroo@hotmail.com
CR Andrews BT, 2006, HEAD NECK-J SCI SPEC, V28, P974, DOI 10.1002/hed.20496
   Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
NR 2
TC 1
Z9 1
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0266-4356
EI 1532-1940
J9 BRIT J ORAL MAX SURG
JI Br. J. Oral Maxillofac. Surg.
PD MAR
PY 2009
VL 47
IS 2
BP 163
EP 164
DI 10.1016/j.bjoms.2008.07.200
PG 2
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA 416YN
UT WOS:000264041500024
PM 18778879
DA 2026-07-24
ER

PT J
AU Braakenburg, A
   Obdeijn, MC
   Feitz, R
   van Rooij, IALM
   van Griethuysen, AJ
   Klinkenbijl, JHG
AF Braakenburg, Assa
   Obdeijn, Miryam C.
   Feitz, Reinier
   van Rooij, Iris A. L. M.
   van Griethuysen, Arjanne J.
   Klinkenbijl, Jean H. G.
TI The clinical efficacy and cost effectiveness of the vacuum-assisted
   closure technique in the management of acute and chronic wounds: A
   randomized controlled trial
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 14th Annual Meeting of the Wound-Healing-Society
CY MAY 24, 2004
CL Atlanta, GA
SP Wound Healing Soc
ID SUBATMOSPHERIC PRESSURE; SURGICAL-PROCEDURES; NEGATIVE-PRESSURE;
   THERAPY; EXPERIENCE; SYSTEM
AB Background: Vacuum-assisted closure therapy is a relatively new concept described in the literature that increases wound-healing capacity. The authors aimed to investigate the effect of vacuum-assisted closure therapy on wound healing, granulation tissue formation, bacterial clearance, pain, time involvement of the staff, and total costs in all types of wounds in comparison with modern wound dressings.
   Methods: Sixty-five patients with a chronic or acute wound were randomized to initial treatment with vacuum-assisted closure or modern dressings. The authors' primary endpoint was a granulated wound or a wound ready for skin grafting or healing by secondary intention.
   Results: The time to the primary endpoint with vacuum-assisted closure therapy was not significantly shorter, except for patients with cardiovascular disease and/or diabetics. Vacuum-assisted closure therapy did not result in significantly faster granulation or wound surface reduction or better bacterial clearance, but patient comfort was an important advantage. Time involvement and costs of nursing staff were significantly lower for the vacuum-assisted closure therapy, but overall costs were similar for both groups.
   Conclusions: With vacuum-assisted closure therapy, wound healing is at least as fast as with modern wound dressings. Especially cardiovascular and diabetic patients benefit from this therapy. The total costs of vacuum-assisted closure are comparable to those of modern wound dressings, but the advantage is its comfort for patients and nursing staff.
C1 Rijnstate Hosp, Dept Surg, NL-6800 TA Arnhem, Netherlands.
   Rijnstate Hosp, Dept Res, NL-6800 TA Arnhem, Netherlands.
   Rijnstate Hosp, Dept Med Microbiol & Med Immunol, NL-6800 TA Arnhem, Netherlands.
   Univ Groningen Hosp, Dept Plast & Reconstruct Surg, Groningen, Netherlands.
   Univ Utrecht, Med Ctr, Dept Plast & Reconstruct Surg, Utrecht, Netherlands.
C3 Rijnstate Hospital; Rijnstate Hospital; Rijnstate Hospital; University
   of Groningen; Utrecht University
RP Klinkenbijl, JHG (通讯作者)，Rijnstate Hosp, Dept Surg, Postal Code 9555, NL-6800 TA Arnhem, Netherlands.
EM jklinkenbijl@alysis.nl
RI van Rooij, Iris/A-5705-2014
OI van Rooij, Iris/0000-0002-9519-966X; Feitz, Reinier/0000-0001-6043-2057
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   Armstrong David G, 2002, Ostomy Wound Manage, V48, P64
   Attinger C E, 2001, Foot Ankle Clin, V6, P627, DOI 10.1016/S1083-7515(02)00010-4
   Banwell P E, 1999, J Wound Care, V8, P79
   Eginton MT, 2003, ANN VASC SURG, V17, P645, DOI 10.1007/s10016-003-0065-3
   Fabian TS, 2000, AM SURGEON, V66, P1136
   Fay M F, 1987, AORN J, V46, P442, DOI 10.1016/S0001-2092(07)66456-4
   Fleischmann W, 1995, Eur J Orthop Surg Traumatol, V5, P37, DOI 10.1007/BF02716212
   Ford CN, 2002, ANN PLAS SURG, V49, P55, DOI 10.1097/00000637-200207000-00009
   FOX JW, 1976, AM J SURG, V132, P673, DOI 10.1016/0002-9610(76)90372-X
   Joseph E, 2000, WOUNDS, V12, P60
   McCallon S K, 2000, Ostomy Wound Manage, V46, P28
   Mendez-Eastman S, 1998, RN, V61, P20
   Morykwas MJ, 1997, ANN PLAS SURG, V38, P553, DOI 10.1097/00000637-199706000-00001
   Morykwas MJ, 2001, ANN PLAS SURG, V47, P547, DOI 10.1097/00000637-200111000-00013
   Mouës CM, 2004, WOUND REPAIR REGEN, V12, P11, DOI 10.1111/j.1067-1927.2004.12105.x
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NR 23
TC 243
Z9 292
U1 0
U2 34
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD AUG
PY 2006
VL 118
IS 2
BP 390
EP 397
DI 10.1097/01.prs.0000227675.63744.af
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 072LM
UT WOS:000239674900018
PM 16874208
DA 2026-07-24
ER

PT J
AU Spiers, J
   Singh, G
   Vinnicombe, Z
   Pouncey, A
   Desai, N
   McEvoy, H
   Lancaster, K
AF Spiers, J.
   Singh, G.
   Vinnicombe, Z.
   Pouncey, A.
   Desai, N.
   McEvoy, H.
   Lancaster, K.
TI Surgical Excision of Axillary Hidradenitis Suppurativa: Comparison of
   Closure with Split Skin Graft and Vacuum-Assisted Closure versus
   Vacuum-Assisted Closure Alone.
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Conference of the
   Association-of-Surgeons-in-Training (ASIT)
CY MAR 22-24, 2019
CL Belfast, NORTH IRELAND
SP Assoc Surg Training
C1 [Spiers, J.; Singh, G.] Kings Coll London, London, England.
   [Vinnicombe, Z.; Pouncey, A.; Desai, N.; McEvoy, H.; Lancaster, K.] St Thomas Hosp, London, England.
C3 University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust
RI Pouncey, Anna Louise/HJB-2757-2022
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2019
VL 106
SU 6
SI SI
MA 0912
BP 122
EP 122
PG 1
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA JA8UZ
UT WOS:000488128100517
DA 2026-07-24
ER

PT J
AU Hodson, T
   West, JM
   Poteet, SJ
   Lee, PH
   Valerio, IL
AF Hodson, Trevor
   West, Julie M.
   Poteet, Stephen J.
   Lee, Peter H.
   Valerio, Ian L.
TI Instillation Negative Pressure Wound Therapy: A Role for Infected LVAD
   Salvage
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE negative pressure; VAC with instillation; debridement; infection
ID PERIPROSTHETIC HIP; MANAGEMENT; SURGERY
AB Objective: To determine the utility of instillation negative pressure wound therapy (NPWT) in achieving eradication of infection and definitive wound closure in patients with infected left ventricular assist device (LVAD).
   Approach: A retrospective review was performed in a series of patients with infected and exposed LVADs who were treated with instillation NPWT in conjunction with surgical debridement.
   Results: Three consecutive patients were included who developed periprosthetic infection subsequent to LVAD implantation. In all cases, the utilization of a vacuum-assisted closure with instillation (VACi) along with surgical debridement and IV antibiotics eradicated infection resulting in successful retention of hardware. Cases 1 and 2 received definitive wound closure within 3 and 12 days of starting treatment, respectively. Case 3 initially deferred surgery in favor of local wound care. Eventually the patient elected for surgical treatment and underwent closure 164 days after initial presentation. All three patients healed completely without residual evidence of infection. Flap reconstruction with a pedicled rectus flap was used to achieve definitive closure in all patients. One patient subsequently required pump replacement secondary to thrombosis and mechanical pump failure.
   Innovation: LVAD infections are met with high morbidity and mortality rates, and timely salvage is critical. In this initial series, VACi has proven a viable therapy option to help control and eradicate infection without LVAD removal.
   Conclusion: This series illustrates the value of newer techniques such as VACi in combination with surgical debridement and antibiotic therapy in effectively salvaging LVADs that were infected.
C1 [Hodson, Trevor; West, Julie M.; Poteet, Stephen J.; Valerio, Ian L.] Ohio State Univ, Wexner Med Ctr, Dept Plast Surg, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
   [Lee, Peter H.] Ohio State Univ, Wexner Med Ctr, Div Cardiac Surg, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Valerio, IL (通讯作者)，Ohio State Univ, Wexner Med Ctr, Dept Plast Surg, 915 Olentangy River Rd,Ste 2100, Columbus, OH 43212 USA.
EM ian.valerio@osumc.edu
RI Valerio, Ian/F-9161-2017
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   Kim PJ, 2015, Wounds, V27, pS2
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   Meaike JD, 2016, SEMIN PLAST SURG, V30, P73, DOI 10.1055/s-0036-1580728
   Ngo QD, 2012, WOUND REPAIR REGEN, V20, P83, DOI 10.1111/j.1524-475X.2011.00747.x
   Nienaber JJC, 2013, CLIN INFECT DIS, V57, P1438, DOI 10.1093/cid/cit536
   Orgill DP, 2013, INT WOUND J, V10, P15, DOI 10.1111/iwj.12170
   Robertson J, 2016, AM J EMERG MED, V34, P1294, DOI 10.1016/j.ajem.2016.04.033
   Sekiguchi Y, 2016, J ARRYTHM, V32, P293, DOI 10.1016/j.joa.2015.09.012
   Söylemez MS, 2016, THER CLIN RISK MANAG, V12, P161, DOI 10.2147/TCRM.S97930
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   Zwolak P, 2013, ORTHOP REV, V5, P128, DOI 10.4081/or.2013.e30
NR 22
TC 11
Z9 12
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD MAR 1
PY 2019
VL 8
IS 3
BP 118
EP 124
DI 10.1089/wound.2018.0832
EA NOV 2018
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HU5DH
UT WOS:000449369000001
PM 31737410
DA 2026-07-24
ER

PT J
AU Bi, HD
   Li, JH
   Xue, CY
   Marks, M
AF Bi, Hongda
   Li, Junhui
   Xue, Chunyu
   Marks, Malcolm
TI Early Closure of Infected Laparotomy Wound with Negative-Pressure Wound
   Therapy: Safety and Efficacy in 42 Consecutive Cases
SO AMERICAN SURGEON
LA English
DT Article
ID SURGICAL SITE INFECTION; VACUUM-ASSISTED CLOSURE; OPEN ABDOMEN; FISTULA
   FORMATION; HIGH-RISK; PREVENTION; GUIDELINE; NPWT; MANAGEMENT; SURGERY
AB Postoperative surgical site infections (SSIs) are one of the most common complications. SSIs after laparotomy have a high incidence and are complicated and expensive to heal. The aim of this study was to evaluate the safety and efficacy of a novel therapy of early closure of open abdominal SSIs wound combining wound irrigation with negative pressure wound therapy (NPWT). Open abdominal SSIs wounds were closed with sutures in 42 consecutive patients. Topical NPWT was applied over a closed wound with a deep drain to allow dynamic drainage and wound irrigation. CT scan with contrast medium injected through the deep drain was performed in patients with suspicious tracts detected during debridement surgery three days after surgery to identify a potential fistula. Wound healing and safety of the therapy was evaluated during an average six months follow-up. Closed wounds healed successfully in all the patients without recurrence of wound infection. Fistulas were easily diagnosed in all four fistula patients by using CT scan with contrast medium injection through the wound. Fistula was confirmed in these four patients at reexploration. All the drain tube wounds healed spontaneously after drain removal. No severe adverse event occurred during therapy in any patients. With the aid of topical NPWT and deep drainage and irrigation, early closure of open SSIs wound can be done safely. We were also able to diagnose gastrointestinal fistulas at an early stage with the use of CT scan imaging after contrast injection into the wound.
C1 [Bi, Hongda; Li, Junhui; Xue, Chunyu] Second Mil Med Univ, Changhai Hosp, Dept Plast Surg, Shanghai, Peoples R China.
   [Marks, Malcolm] Wake Forest Univ, Bowman Gray Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27103 USA.
C3 Naval Medical University; Wake Forest University; Wake Forest Baptist
   Medical Center
RP Marks, M (通讯作者)，Wake Forest Baptist Med Ctr, Plast & Reconstruct Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM mmarks@wakehealth.edu
CR Barker DE, 2007, J AM COLL SURG
   Barker DE, 2007, J AM COLL SURGEONS, V204, P784, DOI 10.1016/j.jamcollsurg.2006.12.039
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NR 35
TC 2
Z9 2
U1 0
U2 5
PU SOUTHEASTERN SURGICAL CONGRESS
PI CUMMING
PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA
SN 0003-1348
EI 1555-9823
J9 AM SURGEON
JI Am. Surg.
PD JUN
PY 2018
VL 84
IS 6
BP 938
EP 946
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GM4JF
UT WOS:000438084600045
PM 29981628
DA 2026-07-24
ER

PT J
AU Arowojolu, OA
   Wirth, GA
AF Arowojolu, Omotayo A.
   Wirth, Garrett A.
TI Sacral and Ischial Pressure Ulcer Management With Negative-Pressure
   Wound Therapy With Instillation and Dwell
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; COMPLEX WOUNDS; BRADEN SCALE; SCIENCE; SYSTEM;
   SALINE; RISK
AB Background: The addition of topical fluid instillation, a programmable "dwell" time and a novel foam-wound interface to the established wound healing benefits of negative-pressure wound therapy (NPWT) works synergistically to benefit patients with complex wounds. This engineering breakthrough for wound care has been termed NPWT with instillation and dwell (NPWTi-d), and the new foam dressings are reticulated open cell foam dressings specifically designed for use with NPWTi-d. This combined technology has shown promise in chronic, complex wounds and has potential for the management of sacral and ischial pressure wounds.
   Methods: A qualitative comprehensive review was performed analyzing articles from PubMed and Medline that reported on the use of NPWTi-d in sacral or ischial pressure ulcers. Case series and case reports were predominant, and results of cases specific to sacral and ischial pressure wounds were extracted from larger studies and summarized for presentation.
   Results: Compared with conventional NPWT alone, NPWTi-d has been shown to help irrigate the wound, remove fibrinous debris, and promote granulation tissue formation. This is associated with a decreased number of operative debridements and decreased hospital length of stay.
   Conclusions: This technology is rapidly demonstrating expanded utilization in hospitalized patients with chronic sacral and ischial pressure ulcers. When used correctly, NPWTi-d serves as an effective "bridge to defined endpoint": whether that is a flap reconstruction, skin grafting, or discharge home with a stable chronic wound and simplified wound care.
C1 [Arowojolu, Omotayo A.] Univ Calif Irvine, Med Ctr, Dept Plast Surg, Irvine, CA USA.
   [Wirth, Garrett A.] Wirth Plast Surg, 1401 Avocado Ave,Suite 810, Newport Beach, CA 92660 USA.
C3 University of California System; University of California Irvine
RP Wirth, GA (通讯作者)，Wirth Plast Surg, 1401 Avocado Ave,Suite 810, Newport Beach, CA 92660 USA.
EM drwirth@wirthplasticsurgery.com
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NR 41
TC 17
Z9 19
U1 3
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JAN
PY 2021
VL 147
IS 1S-1
SU WOUND THER
BP 61S
EP 67S
DI 10.1097/PRS.0000000000007613
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TB6XV
UT WOS:000668089500010
PM 33347064
DA 2026-07-24
ER

PT J
AU Brancaccio, G
   Filippelli, S
   Affinito, V
   Di Donato, RM
AF Brancaccio, Gianluca
   Filippelli, Sergio
   Affinito, Vincenzo
   Di Donato, Roberto M.
TI Use of intermittent high negative pressure vacuum-assisted closure for
   pediatric poststernotomy mediastinitis
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Editorial Material
DE cardiac surgery; mediastinitis; pediatric; vacuum-assisted closure
ID THERAPY
C1 [Brancaccio, Gianluca; Filippelli, Sergio; Affinito, Vincenzo; Di Donato, Roberto M.] Osped Pediat Bambino Gesu, Dept Cardiac Surg, Rome, Italy.
C3 IRCCS Bambino Gesu
RP Brancaccio, G (通讯作者)，Osped Pediat Bambino Gesu, Piazza S Onofrio 4, I-00165 Rome, Italy.
EM gbrancaccio70@hotmail.com
OI brancaccio, gianluca/0000-0001-8113-6513
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   Salazard B, 2008, J PLAST RECONSTR AES, V61, P302, DOI 10.1016/j.bjps.2007.05.004
NR 10
TC 1
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD SEP
PY 2017
VL 18
IS 9
BP 694
EP 695
DI 10.2459/JCM.0b013e32834037b8
PG 2
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FP5SK
UT WOS:000417681900008
PM 21045715
DA 2026-07-24
ER

PT J
AU Rocco, G
AF Rocco, Gaetano
TI The intrathoracic vacuum-assisted closure device in case of
   post-pneumonectomy empyema Reply
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Letter
DE Vacuum-assisted closure; Pneumonectomy; Empyema; Broncho-pleural fistula
C1 [Rocco, Gaetano] Pascale Fdn, Div Thorac Surg, Natl Canc Inst, Dept Thorac Surg & Oncol, I-80131 Naples, Italy.
C3 IRCCS Fondazione Pascale
RP Rocco, G (通讯作者)，Pascale Fdn, Div Thorac Surg, Natl Canc Inst, Via Semmola 81, I-80131 Naples, Italy.
EM gaetano.rocco@btopenworld.com
RI Rocco, Gaetano/K-4801-2016
OI Rocco, Gaetano/0000-0003-4150-8604
CR Krueger T, 2013, EUR J CARDIO-THORAC, V43, P1077, DOI 10.1093/ejcts/ezs577
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   Schneiter D, 2008, J THORAC CARDIOV SUR, V136, P179, DOI 10.1016/j.jtcvs.2008.01.036
NR 6
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD MAY
PY 2013
VL 43
IS 5
BP 1078
EP 1078
DI 10.1093/ejcts/ezs580
PG 1
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 132VS
UT WOS:000318097400053
PM 23171942
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Chen, SJ
   Chen, YX
   Xiao, JR
   Wei, XZ
   Chen, SM
   Jiang, WZ
AF Chen, Shu-jun
   Chen, Yu-xuan
   Xiao, Jian-rui
   Wei, Xiao-zong
   Chen, Shuang-min
   Jiang, Wang-zhan
TI Negative Pressure Wound Therapy in Necrotizing Fasciitis of the Head and
   Neck
SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FOURNIERS GANGRENE; MANAGEMENT
AB Purpose: Necrotizing fasciitis is a severe soft tissue infection that is uncommon in the head and neck region. Despite the advancement of care over the past few decades, the mortality rate remains high. Negative pressure wound therapy (NPWT), an advanced wound-healing technique, has become increasingly popular for a wide variety of complicated wounds. Since December 2015, we have used this technique in the management of necrotizing fasciitis of the head and neck. We report a consecutive case series treated with NPWT as the initial surgical procedure. Materials and
   Methods: Seven patients who received a surgical diagnosis of necrotizing fasciitis of the head and neck underwent surgery under general anesthesia. After complete debridement, an NPWT device was applied for positive drainage of the involved areas. The drainage tube was connected to a central negative pressure system. The device was not replaced or removed until the infection was controlled. Then, a conventional drainage approach was used.
   Results: Of the 7 patients, 6 underwent the surgical procedure and NPWT once; the remaining patient underwent these procedures twice. The infectious cavities showed a clean wound covered with healthy granulation formation during the removal of the NPWT device. The following course was uneventful. The mean time for wound healing was 17.3 +/- 6.1 days.
   Conclusions: NPWT provides various advantages compared with conventional debridement and drainage, resulting in excellent clinical outcomes. This method could be recommended as an alternative approach in the management of necrotizing fasciitis in the head and neck region. (C) 2018 American Association of Oral and Maxillofacial Suggeons
C1 [Chen, Shu-jun; Chen, Yu-xuan; Xiao, Jian-rui; Wei, Xiao-zong; Chen, Shuang-min; Jiang, Wang-zhan] 252nd Hosp Peoples Liberat Army China, Dept Oral & Maxillofacial Surg, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
RP Chen, SJ (通讯作者)，252nd Hosp Peoples Liberat Army China, Dept Oral & Maxillofacial Surg, 991 Baihuadong Rd, Baoding 071000, Peoples R China.
EM shujunchen001@gmail.com
CR Angoules AG, 2007, INJURY, V38, pS19, DOI 10.1016/j.injury.2007.10.030
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NR 26
TC 25
Z9 31
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0278-2391
EI 1531-5053
J9 J ORAL MAXIL SURG
JI J. Oral Maxillofac. Surg.
PD JAN
PY 2019
VL 77
IS 1
BP 87
EP 92
DI 10.1016/j.joms.2018.08.016
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HF9BD
UT WOS:000454535400016
PM 30243707
DA 2026-07-24
ER

PT J
AU Nolff, MC
   Pieper, K
   Meyer-Lindenberg, A
AF Nolff, Mirja C.
   Pieper, Korbinian
   Meyer-Lindenberg, Andrea
TI Treatment of a perforating thoracic bite wound in a dog with negative
   pressure wound therapy
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; SEPTIC PERITONITIS; CATS; SKIN; MANAGEMENT;
   RECONSTRUCTION; GRAFTS; MESH
AB CASE DESCRIPTION
   A 4-year-old male Dachshund was examined following a bite attack that had occurred 5 days previously. The dog had acutely deteriorated despite IV antimicrobial treatment and fluid therapy.
   CLINICAL FINDINGS
   On initial examination, the patient was recumbent with signs of septic shock and a flail chest. Three penetrating wounds in the left thoracic wall with malodorous discharge were evident. The animal trauma triage score was 8 out of 18. Thoracic and abdominal radiography revealed displaced fractures of the left seventh, eighth, and ninth ribs and extensive subcutaneous emphysema. Additionally, a marked diffuse bronchointerstitial pattern, areas of alveolar pattern, and pneumothorax were present bilaterally.
   TREATMENT AND OUTCOME
   Open surgical debridement with left lateral lung lobectomy and resection of portions of the left thoracic wall were performed. Extensive soft tissue loss precluded primary reconstruction. The defect was stabilized with a polypropylene mesh implant, and negative pressure wound therapy (NPWT) at -100 mm Hg was initiated. Microbial culture and susceptibility testing of tissue samples indicated the presence of multidrug-resistant Staphylococcus pseudintermedius. The NPWT dressing was changed 2, 5, and 7 days after surgery. Treatment was well tolerated, and the mesh was completely covered with granulation tissue 10 days after surgery. On follow-up 5, 7, 12, and 19 months after surgery, the dog was clinically normal with no apparent complications.
   CLINICAL RELEVANCE
   Findings suggested that NPWT may be a valuable adjunct when treating small animal patients with severe thoracic trauma.
C1 [Nolff, Mirja C.; Pieper, Korbinian; Meyer-Lindenberg, Andrea] Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
C3 University of Munich
RP Nolff, MC (通讯作者)，Ludwig Maximilians Univ Munchen, Clin Small Anim Surg & Reprod, Vet Str 13, D-80539 Munich, Germany.
EM m.nolff@lmu.de
RI Nolff, Mirja/W-6756-2019; Pieper, Korbinian/HRA-0638-2023;
   Meyer-Lindenberg, Andreas/H-1076-2011
OI Nolff, Mirja/0000-0001-9317-7769; 
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NR 36
TC 6
Z9 7
U1 0
U2 23
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD OCT 1
PY 2016
VL 249
IS 7
BP 794
EP 800
DI 10.2460/javma.249.7.794
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DW5RY
UT WOS:000383705800028
PM 27654166
DA 2026-07-24
ER

PT J
AU Acosta, S
   Björck, M
   Wanhainen, A
AF Acosta, S.
   Bjorck, M.
   Wanhainen, A.
TI Negative-pressure wound therapy for prevention and treatment of
   surgical-site infections after vascular surgery
SO BJS-BRITISH JOURNAL OF SURGERY
LA English
DT Review
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; AORTIC-ANEURYSM
   REPAIR; CLOSED INCISION MANAGEMENT; MEDIATED FASCIAL TRACTION; OPEN
   ABDOMEN TREATMENT; SZILAGYI GRADE III; INTRAABDOMINAL HYPERTENSION;
   ENDOVASCULAR REPAIR; DRESSING CHANGES
AB BackgroundIndications for negative-pressure wound therapy (NPWT) in vascular surgical patients are expanding. The aim of this review was to outline the evidence for NPWT on open and closed wounds.
   MethodsA PubMed, EMBASE and Cochrane Library search from 2007 to June 2016 was performed combining the medical subject headings terms wound infection', abdominal aortic aneurysm (AAA)', fasciotomy', vascular surgery' and NPWT' or VAC'.
   ResultsNPWT of open infected groin wounds was associated with shorter duration of wound healing by 47 days, and was more cost-effective than alginate dressings in one RCT. In one RCT and six observational studies, NPWT-related major bleeding and graft preservation rates were 0-10 and 83-100 per cent respectively. One retrospective comparative study showed greater wound size reduction per day, fewer dressing changes, quicker wound closure and shorter hospital stay with NPWT compared with gauze dressings for lower leg fasciotomy. NPWT and mesh-mediated fascial traction after AAA repair and open abdomen was associated with high primary fascial closure rates (96-100 per cent) and low risk of graft infection (0-7 per cent). One retrospective comparative study showed a significant reduction in surgical-site infection, from 30 per cent with standard wound care to 6 per cent with closed incisional NPWT.
   ConclusionNPWT has a central role in open and infected wounds after vascular surgery; the results of prophylactic care of closed incisions are promising.
C1 [Acosta, S.] Lund Univ, Dept Clin Sci, Vasc Ctr, Malmo, Sweden.
   [Bjorck, M.; Wanhainen, A.] Uppsala Univ, Dept Surg Sci, Vasc Surg, Uppsala, Sweden.
C3 Lund University; Uppsala University
RP Acosta, S (通讯作者)，Skane Univ Hosp, Vasc Ctr, S-20502 Malmo, Sweden.
EM stefan.acosta@telia.com
RI Acosta, Stefan/JAX-3225-2023
OI Acosta, Stefan/0000-0002-3225-0798
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NR 57
TC 50
Z9 62
U1 1
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1323
EI 1365-2168
J9 BJS-BRIT J SURG
JI BJS-Brit. J. Surg.
PD JAN
PY 2017
VL 104
IS 2
BP E75
EP E84
DI 10.1002/bjs.10403
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA EK0CL
UT WOS:000393594000009
PM 27901277
DA 2026-07-24
ER

PT J
AU Ye, CJ
   Zhang, YH
   Han, CM
   Mao, SL
   Ni, LF
   Liu, J
   Wu, JM
   Zhang, JF
AF Ye, Chunjiang
   Zhang, Yuanhai
   Han, Chunmao
   Mao, Shulei
   Ni, Liangfang
   Liu, Jia
   Wu, Junmei
   Zhang, Jianfen
TI A Wound Treatment Strategy for "Super Long-Term Difficult-to-Heal
   Wounds": A Single-Center Retrospective Study
SO INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
LA English
DT Article
DE negative pressure wound therapy; chronic wounds; autologous scalp
   grafting; elderly patients
ID VACUUM-ASSISTED CLOSURE; LOWER-LIMB; THERAPY; ULCERS; MULTICENTER;
   MANAGEMENT; MATRIX; REPAIR
AB Chronic wounds are a challenge for clinicians. Treating chronic wounds in elderly patients is difficult due to comorbidities and poor immunity, tissue renewal, and regeneration. This study shared the therapeutic experiences of 40 patients with super long-term difficult-to-heal wounds and to describe the effects of negative pressure wound therapy (NPWT)-assisted debridement and autologous scalp grafting. Elderly patients with chronic wounds for more than 60 years who underwent NPWT-assisted debridement and autologous scalp grafting between 2015 and 2017 were retrospectively analyzed. Forty patients were identified and analyzed. Among all patients, the average wound area was 56 (interquartile range 30-90) cm(2). The wound infection rate was 82.1%, and that before the first autologous scalp grafting was 51.3%. The average total number of surgeries was 3, and the number of times the NPWT device was replaced was once. A total of 97.4% of patients had one autologous scalp grafting performed. The transplanted scalp survived completely in 97.4% of patients. One hundred percent of patients had no postoperative complications and healed. The average wound healing time was 34.5 +/- 10.1 days. This study showed that NPWT-assisted debridement and autologous scalp grafting have the advantages of high survival rate of the skin and decreased wound recurrence and may be a suitable treatment for super long-term difficult-to-heal wounds in elderly patients.
C1 [Ye, Chunjiang; Zhang, Yuanhai; Mao, Shulei; Ni, Liangfang; Liu, Jia; Wu, Junmei; Zhang, Jianfen] Zhejiang Quhua Hosp, Quzhou, Peoples R China.
   [Han, Chunmao] Zhejiang Univ, Affiliated Hosp 2, Coll Med, Hangzhou, Peoples R China.
C3 Zhejiang University
RP Ye, CJ (通讯作者)，Zhejiang Quhua Hosp, Dept Burns & Plast Surg, 62 Wenchang Rd, Quzhou 324004, Zhejiang, Peoples R China.
EM 5269639@qq.com
FU Basic Public Welfare Research Program of Zhejiang Province
   [LGF18H150001]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Basic
   Public Welfare Research Program of Zhejiang Province (LGF18H150001).
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NR 49
TC 0
Z9 0
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7346
EI 1552-6941
J9 INT J LOW EXTR WOUND
JI Int. J. Low. Extrem. Wounds
PD DEC
PY 2022
VL 21
IS 4
BP 483
EP 491
AR 1534734620960292
DI 10.1177/1534734620960292
EA SEP 2020
PG 9
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 6H4QA
UT WOS:000572775900001
PM 32962469
DA 2026-07-24
ER

PT J
AU Borgquist, O
   Gustafson, L
   Ingemansson, R
   Malmsjö, M
AF Borgquist, Ola
   Gustafson, Lotta
   Ingemansson, Richard
   Malmsjo, Malin
TI Tissue Ingrowth Into Foam but Not Into Gauze During Negative Pressure
   Wound Therapy
SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; FOUNDATION
AB Background. Foam and gauze are two types of wound fillers used for negative pressure wound therapy (NPWT). Differences in the wound healing effects of foam and gauze have been observed clinically. The aim of the present study was to examine the effects of NPWT on the wound bed using foam and gauze. Methods. A porcine peripheral wound model was treated with NPWT at 0, -75 mmHg, or -125 mmHg for 72 hours. The effects of foam and gauze on the wound bed were compared, and the force required to remove the dressings was measured. Sections of biopsies from the wound bed with an overlying dressing were stained with hematoxylin-eosin and Giemsa and were examined histologically. Results. The force ratio needed to remove the wound filler from the wound bed after treatment with negative pressure was greater for foam than for gauze. NPWT caused the wound bed tissue to grow into the foam, while there was I no such ingrowth into gauze. Furthermore, beneath the foam there was more leukocyte infiltration, tissue disorganization, disruption of contact among cells, and differences in size among cells. The results were similar regardless of the level of negative pressure. Conclusion. More force was required to remove foam compared to gauze following NPWT, which may have been due to greater ingrowth into foam. These findings may explain the patient discomfort and wound bed disruption upon removal of foam. The observed differences in wound bed tissue morphology under foam and gauze are in accordance with the clinically observed differences in quality of granulation tissue formation.
C1 [Borgquist, Ola; Gustafson, Lotta; Malmsjo, Malin] Univ Lund Hosp, Dept Ophthalmol, Lund, Sweden.
   [Ingemansson, Richard] Univ Lund Hosp, Dept Cardiothorac Surg, Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital
RP Malmsjö, M (通讯作者)，Lund Univ, Dept Ophthalmol, Lund, Sweden.
EM malin.malmsjo@med.lu.se
RI ; Borgquist, Ola/AAO-6451-2020
OI Maljö, Malin/0000-0001-9849-9599; 
FU Ake-Wieberg Foundation; Magn. Bergvall Foundation; Swedish Medical
   Association; Royal Physiographic Society in Lurid; Swedish Medical
   Research Council; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Government; Swedish Hypertension Society; Prospera
FX The study was financially supported by the Ake-Wieberg Foundation, the
   Magn. Bergvall Foundation, the Swedish Medical Association, the Royal
   Physiographic Society in Lurid, the Swedish Medical Research Council,
   the Crafoord Foundation, the Swedish Heart-Lung Foundation, the Swedish
   Government Grant for Clinical Research, the Swedish Hypertension
   Society, and Prospera. Dr. Malmsjo received a research grant from
   Prospera.
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NR 18
TC 43
Z9 49
U1 0
U2 5
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 1044-7946
EI 1943-2704
J9 WOUNDS
JI Wounds-Compend. Clin. Res. Pract.
PD NOV
PY 2009
VL 21
IS 11
BP 302
EP 309
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 521ZZ
UT WOS:000271967500004
PM 25902776
DA 2026-07-24
ER

PT J
AU Rowan, MP
   Niece, KL
   Rizzo, JA
   Akers, KS
AF Rowan, Matthew P.
   Niece, Krista L.
   Rizzo, Julie A.
   Akers, Kevin S.
TI Wound Penetration of Cefazolin, Ciprofloxacin, Piperacillin, Tazobactam,
   and Vancomycin During Negative Pressure Wound Therapy
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE antibiotic; burn; exudate; pharmacokinetics; trauma; WoundVac
ID VACUUM-ASSISTED CLOSURE; PROTEIN-BINDING; LASER-DOPPLER;
   PHARMACOKINETICS; PHARMACODYNAMICS; BIOMARKERS; DRESSINGS; SURGERY;
   SINGLE; FUTURE
AB Objective: Negative pressure wound therapy (NPWT) uses subatmospheric pressure as a noninvasive adjunct to treat wounds and has demonstrated clinical efficacy by accelerating healing of a variety of acute and chronic wounds. NPWT may also play a role in preventing or treating wound infections, possibly by increasing wound penetration of antibiotics. However, clinical data in patients undergoing antibiotic and NPWT treatment are limited.
   Approach: To evaluate the wound penetration of antibiotics in NPWT patients, we conducted a prospective, observational study of burn and trauma patients treated with NPWT and systemic antibiotics. We evaluated the plasma pharmacokinetic profile of systemic vancomycin, ciprofloxacin, cefazolin, and piperacillin/tazobactam, as well as total and unbound antibiotic concentrations in wound exudate from the same patients.
   Results: Data from 32 patients with 37 wounds undergoing NPWT demonstrated that vancomycin, ciprofloxacin, and piperacillin/tazobactam all penetrated wounds with exudate to plasma concentration ratios more than 0.8. Cefazolin did not penetrate wounds in patients undergoing NPWT as effectively, with an average exudate to plasma concentration ratio of 0.51.
   Innovation: Clinical data on the wound penetration of antibiotics in patients undergoing NPWT are limited, but these data suggest that antibiotics have different capacities for wound penetration during NPWT that should be considered when making clinical decisions.
   Conclusion: This initial report suggests that (1) vancomycin, ciprofloxacin, and piperacillin/tazobactam effectively penetrate wounds during NPWT and (2) cefazolin as well as other antibiotics may not penetrate wounds during NPWT.
C1 [Rowan, Matthew P.; Niece, Krista L.; Rizzo, Julie A.; Akers, Kevin S.] JBSA Ft Sam Houston, United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
   [Rizzo, Julie A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
   [Akers, Kevin S.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX USA.
C3 Uniformed Services University of the Health Sciences - USA; Brooke Army
   Medical Center
RP Akers, KS (通讯作者)，JBSA Ft Sam Houston, United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.; Akers, KS (通讯作者)，JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX USA.
EM kevin.s.akers.mil@mail.mil
FU Defense Medical Research and Development Program (DMRDP) Military
   Infectious Disease Clinical Trial Award (MID-CTA) [D_MIDCTA_I_12_J2_299]
FX This work is dedicated to the life, memory, and enduring spirit of Dr.
   Matthew P. "Matt'' Rowan, PhD, a public servant devoted to the
   betterment of humanity through biomedical research. Dr. Rowan was killed
   a few days after completing this, his final article. We would like to
   thank the research nurses and staff for their assistance in conducting
   this study, especially Doug Johnson for his contribution and effort; the
   Department of Clinical Investigations at Brooke Army Medical Center for
   laboratory support; and Drs. Kevin Chung and Michelle Buehner for
   critical review of the article. This study was conducted under a
   protocol reviewed and approved by the U.S. Army Medical Research and
   Materiel Command Institutional Review Board and in accordance with the
   approved protocol. This research was supported by Defense Medical
   Research and Development Program (DMRDP) Military Infectious Disease
   Clinical Trial Award (MID-CTA) No. D_MIDCTA_I_12_J2_299 and, in part, by
   an appointment (M.P.R.) to the Postgraduate Research Participation
   Program at the U.S. Army Institute of Surgical Research administered by
   the Oak Ridge Institute for Science and Education through an interagency
   agreement between the U.S. Department of Energy and the U.S. Army
   Medical Research and Materiel Command.
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NR 30
TC 11
Z9 12
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD FEB
PY 2017
VL 6
IS 2
BP 55
EP 62
DI 10.1089/wound.2016.0698
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EP3DG
UT WOS:000397262200002
PM 28224048
DA 2026-07-24
ER

PT J
AU Peinemann, F
   Labeit, A
AF Peinemann, Frank
   Labeit, Alexander
TI Negative pressure wound therapy: A systematic review of randomized
   controlled trials from 2000 to 2017
SO JOURNAL OF EVIDENCE BASED MEDICINE
LA English
DT Article
DE negative pressure wound therapy; randomized controlled trials;
   systematic review
ID VACUUM-ASSISTED CLOSURE; SURROGATE END-POINTS; CLINICAL-TRIALS;
   FUNDAMENTALS
AB BackgroundNegative pressure wound therapy (NPWT) proposes to provide better wound healing than standard wound management. Evidence quality of randomized controlled trials (RCTs) varies.
   MethodsWe included participants with any kind of wounds and commercial as well as the homemade NPWT system. Comparators were any other wound dressing including variant NPWTs. We included RCTs randomizing patients or wounds in parallel or crossover designs. We searched PubMed and Cochrane Library on January 03, 2018. We assessed the risk of bias according to Cochrane and appropriateness of clinical endpoints according to the Food and Drug Administration (FDA).
   ResultsWe included 93 RCTs originating in 30 countries, 70 studies on open wounds and 23 studies on closed wounds. With respect to random sequence generation, we judged an unclear or high risk of bias in 50% (47 of 93) studies. With respect to allocation concealment, we judged an unclear or high risk of bias in 90% (84 of 93). We identified 41% (38 of 93) studies that based their conclusion on not appropriate endpoints.
   ConclusionsHigh risk of bias concerning random sequence generation and allocation concealment limited the credibility of the majority of 93 included RCTs on NPWT. A low risk of bias can and should be achieved with both items, and we recommend to align future RCTs to Cochrane. Many primary clinical endpoints were deemed not valid for making inferences on the efficacy of NPWT. We recommend using patient-centered endpoints as requested by the FDA and suggested in the present systematic review.
C1 [Peinemann, Frank] Univ Hosp, Childrens Hosp, Kerpener Str 62, D-50937 Cologne, Germany.
   [Peinemann, Frank] FOM Univ Appl Sci Econ & Management, Essen, Germany.
   [Labeit, Alexander] Univ Manchester, Fac Biol Med & Hlth Sci, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester, Lancs, England.
C3 University of Cologne; University of Manchester
RP Peinemann, F (通讯作者)，Univ Hosp, Childrens Hosp, Kerpener Str 62, D-50937 Cologne, Germany.
EM pubmedprjournal@gmail.com
RI /H-2800-2019
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   Newton K., 2017, COCHRANE DB SYST REV, V1
   Otterbourg K., 2012, Fortune
   Peinemann F, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007540
   Peinemann F, 2011, DTSCH ARZTEBL INT, V108, P381, DOI 10.3238/arztebl.2011.0381
   Pennsylvania Patient Safety Advisory, 2011, PA PATIENT SAF ADVIS, V8, P18
   Schünemann HJ, 2013, RES SYNTH METHODS, V4, P49, DOI 10.1002/jrsm.1078
   The Free Dictionary, WOUND
   Unger CA, 2015, J MINIM INVAS GYN, V22, P573, DOI 10.1016/j.jmig.2015.02.012
   Webster J, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009261.pub3
NR 33
TC 20
Z9 22
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1756-5383
EI 1756-5391
J9 J EVID-BASED MED
JI J Evid.-Based Med.
PD MAY
PY 2019
VL 12
IS 2
BP 125
EP 132
DI 10.1111/jebm.12324
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VK3IO
UT WOS:000678092300005
PM 30460777
OA Bronze
DA 2026-07-24
ER

PT J
AU de la Fuente, PZ
   Castillo, F
   Diban, N
   Lázaro-Martínez, JL
   Revilla, FQ
   Ruiz, GG
   Sancibrian, R
   Peralta, G
AF Zorrilla de la Fuente, Patricia
   Castillo, Federico
   Diban, Nazely
   Lazaro-Martinez, Jose Luis
   Quevedo Revilla, Fernando
   Garcia Ruiz, Gerardo
   Sancibrian, Ramon
   Peralta, Galo
TI Particulate Evacuation Under NPWT: Bench Evaluation of a Multilayer Foam
   Prototype Versus Commercial Dressings in a Simulated Exudate Model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE exudates; negative-pressure dressings; negative-pressure wound therapy;
   wound healing; wounds
ID VACUUM-ASSISTED CLOSURE; PRESSURE WOUND THERAPY
AB Negative pressure wound therapy (NPWT) is widely used to facilitate healing by improving local perfusion, reducing edema and controlling exudate. The porous foam dressing is central to NPWT effectiveness, however, its performance in viscous, particle-rich exudates remains challenging. Standard industry tests often rely on protein-free aqueous solutions, which overlook the complex rheology and particulate load of real wounds. This study reports a bench evaluation of a multilayer foam prototype compared with three commercial dressings under NPWT, using a simulated viscous exudate with suspended particles. We recorded 60-min drainage curves and quantified effluent turbidity as a simple, interpretable proxy for particulate transport, summarised as percentage of input turbidity recovered. The mass-based endpoint (percent solid matter recovered) showed the same ranking as turbidity. At -75 mmHg, the prototype recovered 31.6% of input turbidity, exceeding commercial foams (<= 9.7%). At -125 mmHg, particulate recovery decreased across all dressings (<= 9.1%). A matrix-only control indicated that commercial effluents, particularly at -75 mmHg, clustered near background level, whereas the prototype evacuated substantially more particulate while maintaining robust fluid drainage. These findings suggest that moderate negative pressure and multilayer architecture can help preserve channel patency and reduce clogging in complex exudates. We highlight the need for test methodologies that incorporate viscosity and particulate content, and for practical guidance that links dressing architecture and pressure settings to exudate characteristics. Prospective validation, including larger-sample confirmation, particle-size distributions and ultimately clinical endpoints, is warranted.
C1 [Zorrilla de la Fuente, Patricia; Castillo, Federico; Diban, Nazely; Quevedo Revilla, Fernando; Garcia Ruiz, Gerardo; Peralta, Galo] Inst Invest Sanitaria Valdecilla IDIVAL, Santander, Spain.
   [Zorrilla de la Fuente, Patricia; Sancibrian, Ramon] Univ Cantabria, Santander, Spain.
   [Castillo, Federico] Hosp Univ Marques de Valdecilla, Santander, Spain.
   [Diban, Nazely] Univ Cantabria, Dept Chem & Biomol Engn, Santander, Spain.
   [Lazaro-Martinez, Jose Luis] Univ Complutense Madrid, Madrid, Spain.
   [Lazaro-Martinez, Jose Luis] Hosp Clin San Carlos Madrid IdISSC, Inst Invest Sanitaria, Madrid, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Hospital Universitario Marques de Valdecilla (HUMV);
   Universidad de Cantabria; Complutense University of Madrid
RP de la Fuente, PZ (通讯作者)，Inst Invest Sanitaria Valdecilla IDIVAL, Santander, Spain.; de la Fuente, PZ (通讯作者)，Univ Cantabria, Santander, Spain.
EM patricia.zorrilla@idival.org
RI MARTINEZ, JOSE/AAE-2268-2021; Diban, Nazely/AAA-4459-2019
OI Diban, Nazely/0000-0002-2636-6305
FU Instituto de Investigacin Sanitaria Valdecilla [DTEC21/01, DTEC25/01]
FX This work has been made possible by a research grant (DTEC21/01) and
   grant (DTEC25/01) from Instituto de Investigacion Sanitaria Valdecilla
   (IDIVAL).
CR Argenta LC, 1997, ANN PLAS SURG, V38, P563, DOI 10.1097/00000637-199706000-00002
   de la Fuente PZ, 2024, INT WOUND J, V21, DOI [10.1111/iwj.14964, 10.1111/iwj.14964]
   Gabriel A, 2008, INT WOUND J, V5, P399, DOI 10.1111/j.1742-481X.2007.00423.x
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NR 13
TC 1
Z9 1
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD MAR 10
PY 2026
VL 23
IS 3
AR e70872
DI 10.1111/iwj.70872
PG 8
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EV9FE
UT WOS:001711007800001
PM 41807305
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Ahmad, I
   Khanna, R
   Prakash, P
   Khanna, S
   Meena, RN
AF Ahmad, Irshad
   Khanna, Rahul
   Prakash, Pradyot
   Khanna, Siddharth
   Meena, Ram Niwas
TI Sacral Pressure Ulcer Management by Negative Pressure Dressing: a
   Randomized Open Label Study
SO INDIAN JOURNAL OF SURGERY
LA English
DT Article
DE Sacral pressure ulcer; Negative pressure wound therapy; Vacuum assisted
   closure
ID WOUND THERAPY
AB The treatment of sacral pressure sores is associated with a high rate of failure and recurrence. If inadequately treated, they severely compromise the quality of life and may herald a terminal event. The present study was undertaken to compare the efficacy of negative pressure wound therapy (NPWT) with conventional dressing treatment for sacral pressure sores. Over a 4-year period, 38 patients of grade III and IV sacral pressure sores were treated by either NPWT (22 patients) or conventional dressing (16 patients) method. Prior to application of NPWT, the wound was debrided and complete hemostasis achieved. The NPWT device was set to deliver a negative pressure of 125 mmHg with 7-min cycle (5 min on pump followed by 2 min off). The dressing was changed after 5 to 7 days. At the end of 3 months of treatment, 4 patients had died in each group. Of the 18 patients alive in NPWT group, 6 patients (33%) achieved complete healing and 9 (50%) had wound size reduction by more than 50%. The corresponding figures in the conventional dressing group were 1 (8%) and 4 patients (33%), respectively. NPWT was found to achieve superior clearance of slough, better generation of granulation tissue, and obliteration of ulcer crater compared to conventional dressing. The negative pressure led to faster reduction of bacterial load promoted angiogenesis and obtained a better rate of wound healing. Moreover, it resulted in a much cleaner and hygienic wound environment, reduced the nursing time in change of dressing, and significantly decreased patient discomfort.
C1 [Ahmad, Irshad; Khanna, Rahul; Khanna, Siddharth; Meena, Ram Niwas] Banaras Hindu Univ, Inst Med Sci, Dept Surg, Varanasi 221005, Uttar Pradesh, India.
   [Prakash, Pradyot] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Khanna, R (通讯作者)，Banaras Hindu Univ, Inst Med Sci, Dept Surg, Varanasi 221005, Uttar Pradesh, India.
EM dr_rahul_khanna@rediffmail.com
RI ; Prakash, Pradyot/O-3713-2016
OI Khanna, Rahul/0000-0002-5691-7403; Prakash, Pradyot/0000-0003-3622-4295
CR Bao Philip, 2009, J Surg Res, V153, P347, DOI 10.1016/j.jss.2008.04.023
   Bhattacharya S, 2015, INDIAN J PLAST SURG, V48, P4, DOI 10.4103/0970-0358.155260
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   de Angelis B, 2013, INT WOUND J, V10, P336, DOI 10.1111/j.1742-481X.2012.00982.x
   Desneves KJ, 2005, CLIN NUTR, V24, P979, DOI 10.1016/j.clnu.2005.06.011
   Gabriel A, 2009, INT WOUND J, V6, P1, DOI 10.1111/j.1742-481X.2009.00628.x
   Gargano F, 2017, PRS-GLOB OPEN, V5, DOI 10.1097/GOX.0000000000001234
   Manpinath BD., 2019, NEW INDIA J SURG, V10, P77
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   Webb LX, 2008, J ORTHOP TRAUMA, V22, pS135, DOI 10.1097/BOT.0b013e31818956ce
NR 13
TC 0
Z9 0
U1 1
U2 15
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0972-2068
EI 0973-9793
J9 INDIAN J SURG
JI Indian J. Surg
PD FEB
PY 2023
VL 85
IS 1
BP 65
EP 70
DI 10.1007/s12262-022-03347-x
EA MAR 2022
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 9D9DL
UT WOS:000764911300001
DA 2026-07-24
ER

PT J
AU Raab, S
   Girdauskas, E
   Reindl, S
AF Raab, Stephan
   Girdauskas, Evaldas
   Reindl, Sebastian
TI Treatment of the infection in deep sternal wound infections-a single
   center cohort study
SO JOURNAL OF THORACIC DISEASE
LA English
DT Article
DE Deep sternal wound infection (DSWI); negative pressure wound therapy
   (NPWT); sternum osteomyelitis
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS; CARDIAC-SURGERY
AB Background: In the treatment of deep sternal wound infections (DSWIs) using negative pressure wound therapy (NPWT), infection therapy is separated from reconstruction of the thoracic wall. It is difficult to decide when NPWT can end in order to close the wound. Often ideal conditions cannot be achieved. Must or can sterility be waited for and should antibiotics be administered and if so for how long? These questions are discussed here. Methods: A retrospective single center analysis is performed. Patients who developed a DSWI after cardiac surgery between 2014 and 2020 are included. The following parameters are collected: baseline data, number of negative pressure dressing changes, frequency of persistence of infection and antibacterial therapy performed at closure. Either a short-term antibiotic therapy over 5 days or a therapy corresponding to the osteomyelitis treatment over 6 weeks was carried out. Results: In 79 patients, sterility was achieved after 10.2 +/- 3.9 (mean +/- standard deviation) changes of the negative pressure dressing using NPWT. In 51 patients, NPWT was terminated after 7.4 +/- 5.3 changes without achieving sterility. The number of changes varied significantly. If sterility could be achieved, the frequency of infection complications was significantly lower. Long-term antibiotic therapy resulted in significantly fewer infections than short-term therapy. Conclusions: Microbiological sterility should be achieved if possible. This requires more dressing changes, but the complications are rarer. If it is not possible to wait for sterility, long-term antibiotic therapy is required if osteomyelitis occurs.
C1 [Raab, Stephan; Girdauskas, Evaldas; Reindl, Sebastian] Univ Augsburg, Univ Hosp Augsburg, Fac Med, Clin Cardiothorac Surg, Stenglinstr 2, D-86156 Augsburg, Germany.
C3 University of Augsburg
RP Reindl, S (通讯作者)，Univ Augsburg, Univ Hosp Augsburg, Fac Med, Clin Cardiothorac Surg, Stenglinstr 2, D-86156 Augsburg, Germany.
EM sebastian.reindl@uk-augsburg.de
RI Girdauskas, Evaldas/AAE-7771-2020; Raab, Stephan/OOL-1792-2025
OI Girdauskas, Evaldas/0000-0003-1571-4244; 
CR Assmann A, 2011, THORAC CARDIOV SURG, V59, P25, DOI 10.1055/s-0030-1250598
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NR 19
TC 0
Z9 0
U1 0
U2 0
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2072-1439
EI 2077-6624
J9 J THORAC DIS
JI J. Thorac. Dis.
PD FEB 28
PY 2026
VL 18
IS 2
AR 137
DI 10.21037/jtd-2025-aw-2201
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA EY6IL
UT WOS:001712849100030
PM 41816370
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Liu, Y
   Zhou, Q
   Wang, YC
   Liu, ZC
   Dong, ML
   Wang, YJ
   Li, X
   Hu, DH
AF Liu, Yang
   Zhou, Qin
   Wang, Yunchuan
   Liu, Zhengcai
   Dong, Maolong
   Wang, Yaojun
   Li, Xiao
   Hu, Dahai
TI Negative Pressure Wound Therapy Decreases Mortality in a Murine Model of
   Burn-Wound Sepsis Involving Pseudomonas aeruginosa Infection
SO PLOS ONE
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; INJURY;
   COLONIZATION; PERSISTENCE; VIRULENCE; PATIENT; DEVICE; PAO1; UNIT
AB Background: The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality.
   Methods: Thermal injuries were induced in anesthetized mice, and P. aeruginosa was applied to the wound surface for 24 h. After removing the burn eschar and debridement, the animals were subjected to either NPWT or wet-to-dry (WTD) treatment protocols. The bacterial loads on the wound surface were assessed during 7 d of treatment, as were the concentrations of inflammatory cytokines in the peripheral blood samples. Survival was monitored daily for 14 d after burn induction. Finally, samples of wounded skin, lung, liver, and kidney were collected and subjected to histopathological examination.
   Results: Applying P. aeruginosa to the burn wound surface led to sepsis. During early stages of treatment, NPWT reduced the mortality of the septic animals and levels of P. aeruginosa within the burn wound compared with WTD-treated animals. Circulating levels of cytokines and cytoarchitectural abnormalities were also significantly reduced via NPWT.
   Conclusions: Our data indicate that NPWT inhibits the invasion and proliferation of P. aeruginosa in burn-wounded tissue and decreases early mortality in a murine model of burn-wound sepsis. These therapeutic benefits likely result from the ability of NPWT to decrease bacterial proliferation on the wound surface, reduce cytokine serum concentrations, and prevent damage to internal organs.
C1 [Liu, Yang; Zhou, Qin; Wang, Yunchuan; Dong, Maolong; Wang, Yaojun; Hu, Dahai] Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Shaanxi, Peoples R China.
   [Liu, Zhengcai; Li, Xiao] Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary Surg, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Hu, DH (通讯作者)，Fourth Mil Med Univ, Xijing Hosp, Dept Burns & Cutaneous Surg, Xian 710032, Shaanxi, Peoples R China.
EM hudahaifmmu@163.com
RI ; Wang, Yunchuan/LWK-1681-2024
OI Liu, Zhengcai/0000-0001-5046-440X; Hu, Dahai/0000-0001-5543-092X
FU Academic Support Program Funds of Xijing Hospital, the Fourth Military
   Medical University
FX The study was supported by grants from the Academic Support Program
   Funds of Xijing Hospital, the Fourth Military Medical University. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 32
TC 68
Z9 84
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 28
PY 2014
VL 9
IS 2
AR e90494
DI 10.1371/journal.pone.0090494
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AC3DW
UT WOS:000332396200213
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Villalba-Aguilar, C
   Laredo-Aguilera, JA
   Villalba-Aguilar, L
   Castillo-Hermoso, MI
   Lopez-Fernández-Roldán, A
   Carmona-Torres, JM
AF Villalba-Aguilar, Celia
   Laredo-Aguilera, Jose Alberto
   Villalba-Aguilar, Lucia
   Castillo-Hermoso, Matilde Isabel
   Lopez-Fernandez-Roldan, Angel
   Carmona-Torres, Juan Manuel
TI Comparative Efficacy of Negative Pressure Wound Therapy and Conventional
   Treatments in the Management of Diabetic Foot Ulcers: A Systematic
   Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE diabetic foot ulcer; negative pressure therapy; wound healing;
   granulation tissue; clinical efficacy
ID VACUUM-ASSISTED CLOSURE; COST-EFFECTIVENESS; RANDOMIZED-TRIAL;
   MULTICENTER; SAFETY; CARE
AB Background: Diabetic foot syndrome is a common complication of diabetes mellitus, and its incidence is increasing due to increasing rates of overweight and an aging population. Negative pressure wound therapy has been shown to improve wound healing. This study aimed to analyze the efficacy of this therapy compared with conventional treatments in patients with diabetic foot ulcers. Methods: A systematic search was conducted in the following databases: PubMed, SCOPUS, CINAHL, and the Cochrane Library, and the methodological quality was assessed using the Rob2 scale. This meta-analysis was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: A total of 11 clinical trials involving 1117 subjects. The primary outcome was efficacy, which was measured by the complete healing rate, wound size, time to granulation tissue formation, adverse effects, amputations, hospital stay, and cost. This study demonstrated that this therapy improves healing (OR= -10.39, 95% CI [-14.22, -6.57]) and reduces wound size (OR = -4.11, 95% CI [-7.83, -0.39]) while potentially lowering overall costs. Conclusions: Limitations include heterogeneity and different variables measured in studies. Additionally, there were differences among the trials due to the lack of blinding. Although no significant differences were found in amputations or infections, this therapy reduces pain and decreases the use of antibiotics and analgesics. Its use requires individual and expert assessment to maximize its benefits.
C1 [Villalba-Aguilar, Celia] Hosp Laboral Solimat, Toledo 45004, Spain.
   [Villalba-Aguilar, Celia; Laredo-Aguilera, Jose Alberto; Castillo-Hermoso, Matilde Isabel; Lopez-Fernandez-Roldan, Angel; Carmona-Torres, Juan Manuel] Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria, Toledo 45071, Spain.
   [Laredo-Aguilera, Jose Alberto; Carmona-Torres, Juan Manuel] Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Toledo 45071, Spain.
   [Laredo-Aguilera, Jose Alberto; Carmona-Torres, Juan Manuel] Inst Invest Sanitaria Castilla La Mancha IDISCAM, Toledo 45004, Spain.
   [Villalba-Aguilar, Lucia] Univ Rey Juan Carlos, Fac Ciencias Salud, Alcorcon 28922, Spain.
   [Castillo-Hermoso, Matilde Isabel] Hosp Nacl Paraplej, Toledo 45004, Spain.
   [Lopez-Fernandez-Roldan, Angel] Hosp Univ Toledo, Toledo 45004, Spain.
C3 Universidad de Castilla-La Mancha; Universidad de Castilla-La Mancha;
   Universidad Rey Juan Carlos; Hospital Nacional de Paraplejicos
RP Laredo-Aguilera, JA (通讯作者)，Univ Castilla La Mancha, Fac Fisioterapia & Enfermeria, Toledo 45071, Spain.; Laredo-Aguilera, JA (通讯作者)，Univ Castilla La Mancha, Grp Invest Multidisciplinar Cuidados IMCU, Toledo 45071, Spain.; Laredo-Aguilera, JA (通讯作者)，Inst Invest Sanitaria Castilla La Mancha IDISCAM, Toledo 45004, Spain.
EM celia.villalbaa@hotmail.com; josealberto.laredo@uclm.es;
   luciavillalbaaguilar12@gmail.com; matildei.castillo@uclm.es;
   angel.lopezfernandez@uclm.es; juanmanuel.carmona@uclm.es
RI Castillo Hermoso, Matilde/LTF-0979-2024; CARMONA TORRES, JUAN
   MANUEL/E-1579-2018; López Fernández-Roldán, Ángel/OPO-0857-2025; Laredo
   Aguilera, José Alberto/ABR-3810-2022
OI Castillo Hermoso, Matilde/0009-0009-7947-6282; Villalba Aguilar,
   Celia/0009-0003-2766-224X; CARMONA TORRES, JUAN
   MANUEL/0000-0002-7781-872X; López Fernández-Roldán,
   Ángel/0009-0000-7285-0504; Laredo Aguilera, José
   Alberto/0000-0002-3661-3584
FU UCLM
FX Open Access funding enabled and organized by UCLM.
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NR 68
TC 2
Z9 2
U1 3
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV 13
PY 2025
VL 14
IS 22
AR 8051
DI 10.3390/jcm14228051
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F9098
UT WOS:001624013300001
PM 41303087
OA gold
DA 2026-07-24
ER

PT J
AU Brownhill, VR
   Huddleston, E
   Bell, A
   Hart, J
   Webster, I
   Hardman, MJ
   Wilkinson, HN
AF Brownhill, Varuni R.
   Huddleston, Elizabeth
   Bell, Andrea
   Hart, Jeffrey
   Webster, Iain
   Hardman, Matthew J.
   Wilkinson, Holly N.
TI Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy
   During In Vivo Porcine Wound Healing
SO ADVANCES IN WOUND CARE
LA English
DT Article
DE NPWT; porcine; wound healing; pressure
ID VACUUM-ASSISTED CLOSURE; NONHEALING WOUNDS; FOAM; EXPRESSION;
   MANAGEMENT; TRAUMA
AB Objective: Traditional negative pressure wound therapy (tNPWT) systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO (TM), a no canister single-use system, offers a lightweight, portable alternative to tNPWT, with improved clinical performance. The aim of this study was to determine the potential mechanism(s) of action of single-use NPWT (sNPWT) versus tNPWT.
   Approach: sNPWT and tNPWT were applied to an in vivo porcine excisional wound model, following product use guidelines. Macroscopic, histological, and biochemical analyses were performed at defined healing time points to assess multiple aspects of the healing response.
   Results: Wounds treated with single-use negative pressure displayed greater wound closure and increased reepithelialization versus those treated with traditional negative pressure. The resulting granulation tissue was more advanced with fewer neutrophils, reduced inflammatory markers, more mature collagen, and no wound filler-associated foreign body reactions. Of note, single-use negative pressure therapy failed to induce wound edge epithelial hyperproliferation, while traditional negative pressure therapy compromised periwound skin, which remained inflamed with high transepidermal water loss; features not observed following single-use treatment.
   Innovation: Single-use negative pressure was identified to improve multiple aspects of healing versus traditional negative pressure treatment.
   Conclusion: This study provides important new insight into the differing mode of action of single-use versus traditional negative pressure and may go some way to explaining the improved clinical outcomes observed with single-use negative pressure therapy.
C1 [Brownhill, Varuni R.; Huddleston, Elizabeth; Webster, Iain] TJ Smith & Nephew Ltd, Kingston Upon Hull, N Humberside, England.
   [Bell, Andrea; Hart, Jeffrey] Cica Biomed Ltd, Knaresborough, England.
   [Hardman, Matthew J.; Wilkinson, Holly N.] Univ Hull, Hull York Med Sch, Ctr Atherothrombosis & Metab Dis, Kingston Upon Hull, N Humberside, England.
C3 University of Hull; University of York - UK
RP Hardman, MJ (通讯作者)，Univ Hull, Hull York Med Sch, Ctr Atherothrombosis & Metab Dis, Castle Hill Hosp, Daisy Bldg,2nd Floor, Kingston Upon Hull HU16 5JQ, N Humberside, England.
EM m.hardman@hull.ac.uk
RI Hardman, Matthew/ABE-4936-2020
FU TJ Smith and Nephew Ltd.; Cica Biomedical Ltd.; University of Hull
FX We would like to thank Benjamin Gardner for assistance with sNPWT device
   pump analysis. This study was funded by TJ Smith and Nephew Ltd. in
   collaboration with the University of Hull and Cica Biomedical Ltd.
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NR 42
TC 27
Z9 31
U1 1
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD JUL 1
PY 2021
VL 10
IS 7
BP 345
EP 356
DI 10.1089/wound.2020.1218
EA NOV 2020
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA SJ0GO
UT WOS:000592283700001
PM 32633639
OA Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Seidel, D
   Diedrich, S
   Herrle, F
   Thielemann, H
   Marusch, F
   Schirren, R
   Talaulicar, R
   Gehrig, T
   Lehwald-Tywuschik, N
   Glanemann, M
   Bunse, J
   Hüttemann, M
   Braumann, C
   Heizman, O
   Miserez, M
   Krönert, T
   Gretschel, S
   Lefering, R
AF Seidel, Dorthe
   Diedrich, Stephan
   Herrle, Florian
   Thielemann, Henry
   Marusch, Frank
   Schirren, Rebekka
   Talaulicar, Recca
   Gehrig, Tobias
   Lehwald-Tywuschik, Nadja
   Glanemann, Matthias
   Bunse, Joerg
   Huettemann, Martin
   Braumann, Chris
   Heizman, Oleg
   Miserez, Marc
   Kroenert, Thomas
   Gretschel, Stephan
   Lefering, Rolf
TI Negative Pressure Wound Therapy vs Conventional Wound Treatment in
   Subcutaneous Abdominal Wound Healing Impairment The SAWHI Randomized
   Clinical Trial
SO JAMA SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; QUALITY-OF-LIFE; RISK-FACTORS; SURGERY; GROIN;
   INFECTIONS; ALGINATE
AB IMPORTANCE Negative pressure wound therapy (NPWT) is an established treatment option, but there is no evidence of benefit for subcutaneous abdominal wound healing impairment (SAWHI).
   OBJECTIVE To evaluate the effectiveness and safety of NPWT for SAWHI after surgery in clinical practice.
   DESIGN, SETTING, AND PARTICIPANTS The multicenter, multinational, observer-blinded, randomized clinical SAWHI study enrolled patients between August 2, 2011, and January 31, 2018. The last follow-up date was June 11, 2018. The trial included 34 abdominal surgical departments of hospitals in Germany, Belgium, and the Netherlands, and 539 consecutive, compliant adult patients with SAWHI after surgery without fascia dehiscence were randomly assigned to the treatment arms in a 1:1 ratio stratified by study site and wound size using a centralized web-based tool. A total of 507 study participants (NPWT, 256; CWT, 251) were assessed for the primary end point in the modified intention-to-treat (ITT) population.
   INTERVENTIONS Negative pressure wound therapy and conventional wound treatment (CWT).
   MAIN OUTCOMES AND MEASURES The primary outcome was time until wound closure (delayed primary closure or by secondary intention) within 42 days. Safety analysis comprised the adverse events (AEs). Secondary outcomes included wound closure rate, quality of life (SF-36), pain, and patient satisfaction.
   RESULTS Of the 507 study participants included in the modified ITT population, 287 were men (56.6%) (NPWT, 155 [60.5%] and CWT, 132 [52.6%)) and 220 were women (43.4%) (NPWT, 101[39.5%) and CWT 119 [47.4%)). The median (IQR) age of the participants was 66 (18) years in the NPWT arm and 66 (20) years in the CWT arm. Mean time to wound closure was significantly shorter in the NPWT arm (36.1days) than in the CWT arm (39.1days) (difference, 3.0 days; 95% CI 1.6-4.4; P < .001). Wound closure rate within 42 days was significantly higher with NPWT (35.9%) than with CWT (21.5%) (difference, 14.4%; 95% CI, 6.6%-22.2%; P < .001). In the therapy-compliant population, excluding study participants with unauthorized treatment changes (NPWT, 22; CWT, 50), the risk for wound-related AEs was higher in the NPWT arm (risk ratio, 1.51; 95% CI, 0.99-2.35).
   CONCLUSIONS AND RELEVANCE Negative pressure wound therapy is an effective treatment option for SAWHI after surgery; however, it causes more wound-related AEs.
C1 [Seidel, Dorthe; Lefering, Rolf] Univ Witten Herdecke, Inst Res Operat Med, Cologne, Germany.
   [Diedrich, Stephan] Greifswald Univ Hosp, Dept Gen Surg Visceral Thorac & Vasc Surg, Greifswald, Germany.
   [Herrle, Florian] Heidelberg Univ, Med Fac Mannheim, Dept Surg, Mannheim, Germany.
   [Thielemann, Henry] Unfallkrankenhaus Berlin, Dept Gen & Abdominal Surg, Berlin, Germany.
   [Marusch, Frank] Klinikum Ernst von Bergmann Gemeinnutzige GmbH, Dept Gen & Visceral Surg, Potsdam, Germany.
   [Schirren, Rebekka] Techn Univ Munich, Hosp Rechts Isar, Dept & Polyclin Surg, Munich, Germany.
   [Talaulicar, Recca] Univ Med Ctr Gottingen, Dept Gen Visceral & Pediat Surg, Gottingen, Germany.
   [Gehrig, Tobias] GRN Klin Sinsheim, Dept Gen & Visceral Surg, Sinsheim, Germany.
   [Lehwald-Tywuschik, Nadja] Hosp Heinrich Heine Univ Dusseldorf, Dept Surg A, Dusseldorf, Germany.
   [Glanemann, Matthias] Saarland Univ, Dept Gen Visceral Vasc & Pediat Surg, Homburg, Germany.
   [Bunse, Joerg] Sana Klinikum Lichtenberg, Dept Gen & Visceral Surg, Berlin, Germany.
   [Huettemann, Martin] Evangel Krankenhaus, Dept Gen & Visceral Surg, Oberhausen, Germany.
   [Braumann, Chris] St Josef Hosp Bochum, Dept Gen & Visceral Surg, Bochum, Germany.
   [Heizman, Oleg] Agaples Diakonieklinikum Rotenburg Gemeinnutzige, Dept Gen Visceral & Thorac Surg, Rotenburg, Wumme, Germany.
   [Miserez, Marc] Univ Hosp Katholieke Univ Leuven, Dept Abdominal Surg, Leuven, Belgium.
   [Kroenert, Thomas] Thuringen Kliniken Georgius Agr, Dept Vasc Surg, Ctr Vasc Med, Saalfeld, Germany.
   [Gretschel, Stephan] Univ Hosp Neuruppin, Dept Gen & Visceral Surg, Brandenburg Med Sch, Neuruppin, Germany.
C3 Witten Herdecke University; Ruprecht Karls University Heidelberg;
   Klinikum Ernst von Bergmann; Technical University of Munich; Heinrich
   Heine University Dusseldorf; Heinrich Heine University Dusseldorf
   Hospital; Universitatsklinikum des Saarlandes; Ruhr University Bochum
RP Seidel, D (通讯作者)，Univ Witten Herdecke, Inst Forsch Operat Med IFOM, Ostmerheimerstr 200 Haus 38, D-51109 Cologne, Germany.
EM dortheseidel@gmx.de
OI , marc/0000-0002-7047-6114
FU Kinetic Concepts Incorporated, an Acelity company
FX The SAWHI-study was funded by the manufacturer Kinetic Concepts
   Incorporated, an Acelity company, which included the financing of
   personnel and material resources for planning, conduct, analysis and
   report of the study. In addition, the manufacturer provided the vacuum
   assisted closure (VAC) therapy devices and associated consumable
   supplies.
CR Acelity. V.A.C, THER CLIN GUID REF S
   Acosta S, 2013, INT WOUND J, V10, P377, DOI 10.1111/j.1742-481X.2012.00993.x
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NR 26
TC 52
Z9 62
U1 2
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD JUN
PY 2020
VL 155
IS 6
BP 469
EP 478
DI 10.1001/jamasurg.2020.0414
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA MD6IU
UT WOS:000544076100008
PM 32293657
OA Green Accepted, Green Submitted, hybrid
DA 2026-07-24
ER

PT J
AU Pieszko, K
   Pieszko, K
   Wichtowski, M
   Ciesla, S
   Lawnicka, A
   Jamont, R
   Boyd, JB
   Murawa, D
AF Pieszko, Karolina
   Pieszko, Konrad
   Wichtowski, Mateusz
   Ciesla, Slawomir
   Lawnicka, Agnieszka
   Jamont, Robert
   Boyd, J. Brian
   Murawa, Dawid
TI A Randomized Study Comparing Closed-Incision Negative-Pressure Wound
   Therapy with Standard Care in Immediate Breast Reconstruction
SO PLASTIC AND RECONSTRUCTIVE SURGERY
LA English
DT Article; Proceedings Paper
CT International Society of Aesthetic Plastic Surgery (ISAPS) World
   Congress
CY SEP 11-13, 2021
CL Vienna, AUSTRIA
ID VACUUM-ASSISTED CLOSURE; MASTECTOMY
AB Background:Breast cancer remains the most common nonskin cancer among women. Prophylactic methods for reducing surgical-site complications after immediate breast reconstruction (IBR) are crucial to prevent acellular dermal matrices or prosthesis exposure and loss. The authors assessed the impact of closed-incision negative-pressure wound therapy (ciNPWT) versus standard dressings (ST) after IBR on surgical-site complications, superficial skin temperature (SST), skin elasticity, and subjective scar quality, to determine the potential benefit of prophylactic ciNPWT application. Methods:A multicenter randomized controlled study of 60 adult female patients was conducted between January of 2019 and July of 2021. All patients had oncologic indications for IBR using implants or expanders. Results:Application of ciNPWT correlated with a significant decrease in surgical-site complications within 1 year of surgery (total, 40%; ST, 60%; ciNPWT, 20%; P = 0.003) and resulted in more elastic scar tissue as measured with a Cutometer (average coefficient of elasticity, 0.74; ST, 0.7; ciNPWT, 0.9; P < 0.001). The SST of each scar 1 week after surgery was significantly higher in the ciNPWT group (average SST, 31.5; ST SST, 31.2; ciNPWT SST, 32.3; P = 0.006). According to the Patient and Observer Scar Assessment Scale v2.0, subjective scar outcomes in both groups were comparable. Conclusions:This is the first randomized controlled study that demonstrated a significant decrease in surgical-site wound complications within 1 year of surgery in IBR patients receiving ciNPWT. A high probability of postoperative radiotherapy should be a relative indication for the use of ciNPWT.
C1 [Pieszko, Karolina; Ciesla, Slawomir; Lawnicka, Agnieszka; Murawa, Dawid] Univ Zielona Gora, Clin Gen Surg & Surg Oncol, Zielona Gora, Poland.
   [Pieszko, Konrad] Univ Zielona Gora, Fac Med & Hlth Sci, Zielona Gora, Poland.
   [Pieszko, Karolina; Jamont, Robert] Hosp Nowa Sol, Dept Plast Surg & Burns, Nowa Sol, Poland.
   [Pieszko, Karolina; Boyd, J. Brian] Harbor UCLA Med Ctr, Dept Surg, Div Plast Surg, Torrance, CA USA.
   [Wichtowski, Mateusz; Murawa, Dawid] Poznan Univ Med Sci, Surg Oncol Clin, Poznan, Poland.
   [Pieszko, Karolina] Zyty 2, PL-665190 Zielona Gora, Poland.
C3 University of Zielona Gora; University of Zielona Gora; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; Poznan University of Medical
   Sciences
RP Pieszko, K (通讯作者)，Zyty 2, PL-665190 Zielona Gora, Poland.
EM drkarolina.pieszko@gmail.com
RI Wichtowski, Mateusz/JND-9290-2023; Pieszko, Konrad/GYE-2249-2022
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   American Cancer Society, BREAST CANC WHAT IS
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NR 33
TC 19
Z9 22
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0032-1052
EI 1529-4242
J9 PLAST RECONSTR SURG
JI Plast. Reconstr. Surg.
PD JUN
PY 2023
VL 151
IS 6
BP 1123
EP 1133
DI 10.1097/PRS.0000000000010110
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA H2OK6
UT WOS:000994409400022
PM 36728789
DA 2026-07-24
ER

PT J
AU Zhao, JC
   Xian, CJ
   Yu, JA
   Shi, K
   Hong, L
AF Zhao, Jing-Chun
   Xian, Chun-Jing
   Yu, Jia-Ao
   Shi, Kai
   Hong, Lei
TI Hypertonic Glucose Combined with Negative Pressure Wound Therapy to
   Prepare Wounds with Pseudomonas aeruginosa Infection for Skin
   Grafting: A Report of 3 Cases
SO OSTOMY WOUND MANAGEMENT
LA English
DT Article
DE case report; wound; Pseudomonas infections; hypertonic glucose solution
ID VACUUM-ASSISTED CLOSURE; PROSPECTIVE RANDOMIZED-TRIAL; SUPER-OXIDIZED
   WATER; IN-VITRO; SALINE SOLUTION; OPEN FRACTURE; BURN PATIENT;
   BLOOD-FLOW; SILVER; EXPERIENCE
AB Soft tissue losses from acute or chronic trauma are a challenge for surgeons. To explore a method to expedite granulation tissue formation in preparation for a split-thickness skin graft (STSG), the medical records of 3 patients - 2 adult men with wounds related to trauma injury and 1 infant with necrotizing fasciitis, all infected with Pseudomonas aeruginosa - were reviewed. All wounds were surgically debrided and managed by applying gauze soaked in 50% glucose followed by continuous negative pressure wound therapy (NPWT) before definitive skin grafting. NPWT pressure was applied at -80 mm Hg for the 2 adult males (ages 39 and 25 years) and -50 mm Hg for the 7-month-old male infant. The dressings were changed every 2 to 3 days. No adverse events occurred, and wounds were successfully closed with a STSG after an average of 7 days. In 1 case, NPWT was able to help affix dressings in a difficult-to-dress area (genital region). The combination of hypertonic glucose and hand-made, gauze-based NPWT was found to be safe, well-tolerated, and effective in preparing the wound bed for grafting. Prospective, randomized, controlled clinical studies are needed to compare the safety, effectiveness, and efficacy of this method to other treatment approaches for P. aeruginosa-infected wounds.
C1 [Zhao, Jing-Chun; Xian, Chun-Jing; Yu, Jia-Ao; Shi, Kai] Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Jilin Province, Peoples R China.
   [Shi, Kai; Hong, Lei] Jilin Univ, Hosp 1, Changchun 130031, Jilin Province, Peoples R China.
C3 Jilin University; Jilin University
RP Shi, K (通讯作者)，Jilin Univ, Hosp 1, Burns & Plast Reconstruct Unit, 3302 Jilin Rd, Changchun 130031, Jilin Province, Peoples R China.
EM bu_dong007@163.com
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NR 70
TC 5
Z9 9
U1 0
U2 7
PU H M P COMMUNICATIONS
PI MALVERN
PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA
SN 0889-5899
EI 1943-2720
J9 OSTOMY WOUND MANAG
JI Ostomy Wound Manag.
PD JUN
PY 2015
VL 61
IS 6
BP 28
EP 44
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA DC8MM
UT WOS:000369473700003
PM 26061405
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Hansson, J
   Hlebowicz, J
AF Lindstedt, Sandra
   Hansson, Johan
   Hlebowicz, Joanna
TI The effect of negative wound pressure therapy on haemodynamics in a
   laparostomy wound model
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Haemodynamics; Laparostomy; Negative pressure wound therapy; Wound
   management
ID VACUUM-ASSISTED CLOSURE; ABDOMINAL COMPARTMENT SYNDROME; MICROVASCULAR
   BLOOD-FLOW; OPEN ABDOMEN; INTESTINAL WALL; MANAGEMENT; SEPSIS
AB We have recently shown that negative pressure wound therapy (NPWT) induces a decrease in microvascular blood flow in the small intestinal loop close to the dressing. The effect of NPWT is thus thought to be local. In this study, we investigate whether the application of NPWT in laparostomy affects the haemodynamics. Midline incisions were made in six pigs followed by NPWT at 120 mmHg for 20 minutes. The cardiac output, mean systemic arterial pressure, mean pulmonary artery pressu re, central venous pressure, left atrial pressure and superior mesenteric artery blood flow were recorded. The blood flow in a small branch of the superior mesenteric artery was then recorded under NPWT between 50 and 175 mmHg. Cardiac output was not affected by NPWT [P = not significant (n.s.)]. Neither the mean arterial pressure nor the mean pulmonary artery pressure was affected by NPWT (P = n.s.). Negative pressures of 50, 75, 100 and 125 mmHg did not alter the blood flow in the small branch of the superior mesenteric artery (P = n.s.). After application of 150 mmHg, a significant decrease in blood flow was seen (P < 0 center dot 01), while the application of 175 mmHg resulted in only a slight decrease in blood flow (P = n.s.). The effect of NPWT in laparotomy seems to be local and to have no influence on central haemodynamics or the blood flow to the superior mesenteric artery.
C1 [Lindstedt, Sandra] Univ Lund Hosp, Dept Cardiothorac Surg, S-22185 Lund, Sweden.
   [Hansson, Johan] Uppsala Univ, Fac Med, Dept Surg Sci, Uppsala, Sweden.
   [Hlebowicz, Joanna] Malmo Univ Hosp, Dept Med, Lund, Sweden.
C3 Lund University; Skane University Hospital; Uppsala University; Lund
   University; Skane University Hospital
RP Lindstedt, S (通讯作者)，Lund Univ, Skane Univ Hosp, Heart & Lung Ctr, Dept Cardiothorac Surg, SE-22185 Lund, Sweden.
EM sandra.lindstedt@skane.se
RI Lindstedt, Sandra/AEM-2892-2022
OI Lindstedt, Sandra/0000-0003-4484-6473
FU Crafoord Foundation; Region Skane
FX This study was supported by the Crafoord Foundation and Region Skane.
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NR 24
TC 4
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD JUN
PY 2013
VL 10
IS 3
BP 285
EP 290
DI 10.1111/j.1742-481X.2012.00974.x
PG 6
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA 146CF
UT WOS:000319065700010
PM 22515427
OA Green Submitted
DA 2026-07-24
ER

PT J
AU Kawashima, J
   Sahara, K
   Yamagishi, S
AF Kawashima, Jun
   Sahara, Kota
   Yamagishi, Shigeru
TI Prophylactic negative pressure wound therapy following colorectal
   perforation: defining the risk factors for delayed wound healing
SO SURGERY TODAY
LA English
DT Article
DE NPWT; Colorectal perforation; Delayed wound healing
ID SURGICAL SITE INFECTION; CLOSED INCISION MANAGEMENT; VACUUM-ASSISTED
   CLOSURE; SURGERY; CATECHOLAMINES; COMPLICATIONS; HERNIA; IMPACT; REPAIR;
   CARE
AB Purpose The World Health Organization recommends prophylactic negative pressure wound therapy (NPWT) for high-risk SSI wounds, despite which delayed wound healing (DWH) remains a problem. The aim of this study was to define the risk factors for DWH under prophylactic NPWT following colorectal perforation (CP). Methods The subjects of this retrospective study were patients who underwent emergency laparotomy and prophylactic NPWT for CP between 2011 and 2019 at Fujisawa City Hospital in Japan. Multivariable analysis was performed to identify which perioperative factors impact DWH. Results A total of 58 patients met the inclusion criteria and the median period from surgery to wound closure was 12 days (IQR: 8-18). Most factors, including preoperative steroid use, diabetes, and serum albumin, were not associated with DWH, although patients requiring catecholamine were more likely to have DWH (OR 7.81, 95% CI 1.55-39.24, p = 0.013). The median in-hospital cost was more than double for patients with DWH vs. those without DWH (41.36 kUSD [IQR 24.95-51.89] vs. 20.32 kUSD [IQR 16.69-28.45], p < 0.001). Conclusion Catecholamine use was a greater risk factor for DWH than previously reported factors such as diabetes and the serum albumin level. Further study is needed to investigate strategies to prevent DWH and optimize the utilization of NPWT, especially in patients requiring catecholamine.
C1 [Kawashima, Jun; Sahara, Kota; Yamagishi, Shigeru] Fujisawa City Hosp, Dept Surg, 2-6-1 Fujisawa, Fujisawa, Kanagawa, Japan.
RP Yamagishi, S (通讯作者)，Fujisawa City Hosp, Dept Surg, 2-6-1 Fujisawa, Fujisawa, Kanagawa, Japan.
EM gishiyama1225@yahoo.co.jp
RI Kawashima, Jun/PQX-1843-2026
OI Kawashima, Jun/0000-0003-1072-0776
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NR 47
TC 3
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD JUN
PY 2023
VL 53
IS 6
BP 728
EP 735
DI 10.1007/s00595-022-02631-3
EA DEC 2022
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA H3GQ6
UT WOS:000897782800001
PM 36504070
DA 2026-07-24
ER

PT J
AU Vinnicombe, Z
   Pouncey, A
   Spiers, J
   Singh, G
   McEvoy, H
   Lancaster, K
AF Vinnicombe, Zak
   Pouncey, Anna
   Spiers, Jessica
   Singh, Gurdas
   McEvoy, Helen
   Lancaster, Katie
TI Comparison of surgical excision of axillary hidradenitis suppurativa
   followed by split skin graft and vacuum assisted closure versus vacuum
   assisted closure alone
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
   Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI)
CY 2019
CL Telford, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Vinnicombe, Zak; Pouncey, Anna; McEvoy, Helen; Lancaster, Katie] Guys & St Thomas Hosp, London, England.
   [Spiers, Jessica; Singh, Gurdas] Kings Coll London, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust; University of London; King's
   College London
RI Pouncey, Anna Louise/HJB-2757-2022
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2019
VL 106
SU 5
SI SI
MA SP 7.2.5
BP 32
EP 32
PG 1
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA IW4WO
UT WOS:000484980700096
DA 2026-07-24
ER

PT J
AU Inoue, M
   Uchida, K
   Matsushita, K
   Koike, Y
   Toiyama, Y
AF Inoue, Mikihiro
   Uchida, Keiichi
   Matsushita, Kohei
   Koike, Yuhki
   Toiyama, Yuji
TI Incisional negative pressure wound therapy for perineal wound in Crohn's
   disease
SO PEDIATRICS INTERNATIONAL
LA English
DT Editorial Material
DE abdominoperineal resection; Crohn's disease; negative pressure wound
   therapy; perineal wound
C1 [Inoue, Mikihiro; Uchida, Keiichi; Matsushita, Kohei; Koike, Yuhki; Toiyama, Yuji] Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
C3 Mie University
RP Inoue, M (通讯作者)，Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
EM mikihiro@clin.medic.mie-u.ac.jp
OI Inoue, Mikihiro/0000-0003-4573-0405
CR Cahill C, 2018, INT WOUND J, V15, P740, DOI 10.1111/iwj.12921
   Chen B, 2017, MEDICINE, V96, P13
   de Jesus LE, 2018, J PEDIATR SURG, V53, P585, DOI 10.1016/j.jpedsurg.2017.11.048
   Kuper TM, 2020, ANN SURG, V271, P67, DOI 10.1097/SLA.0000000000003435
   Phillips MR, 2020, J PEDIATR SURG, V55, P1470, DOI 10.1016/j.jpedsurg.2019.10.011
   Zwanenburg PR, 2020, ANN SURG, V272, P81, DOI 10.1097/SLA.0000000000003644
NR 6
TC 1
Z9 1
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1328-8067
EI 1442-200X
J9 PEDIATR INT
JI Pediatr. Int.
PD APR
PY 2021
VL 63
IS 4
BP 475
EP 477
DI 10.1111/ped.14435
EA MAR 2021
PG 3
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA RP6NV
UT WOS:000625666800001
PM 33675280
DA 2026-07-24
ER

PT J
AU Tang, XH
   Guo, PH
   Wong, HT
   Xie, JH
   Han, JD
   Xu, YB
   Zhou, H
AF Tang, Xuhua
   Guo, Penghao
   Wong, Hioteng
   Xie, Jiahui
   Han, Jiande
   Xu, Yingbin
   Zhou, Hui
TI Vacuum-Assisted Closure and Skin Grafting Combined with Amphotericin B
   for Successful Treatment of an Immunocompromised Patient with Cutaneous
   Mucormycosis Caused by Mucor irregularis: A Case Report and
   Literature Review
SO MYCOPATHOLOGIA
LA English
DT Review
DE Mucor irregularis; Rhizomucor variabilis; Amphotericin B; Cutaneous
   mucormycosis; Debridement; Negative-pressure wound therapy
ID RHIZOMUCOR-VARIABILIS; INFECTION; EPIDEMIOLOGY; SURGERY; AGENT
AB Cutaneous mucormycosis caused by Mucor irregularis (M. irregularis) is a rare condition that typically occurs in immunocompetent patients. Herein, we describe an immunocompromised patient with cutaneous M. irregularis infection who was successfully treated with debridement combined with vacuum assisted closure (VAC) negative pressure technique and split-thickness skin grafting. We present this case owing to its complexity and rarity and the successful treatment with surgical therapy. A 58-year-old man presented to our hospital with a history of skin ulcers and eschar on the right lower leg since two months. He had been receiving methylprednisolone therapy for bullous pemphigoid that occurred five months prior to the present lesions. Histopathological examination of a right leg lesion showed broad, branching hyphae in the dermis. Fungal culture and subsequent molecular cytogenetic analysis identified the pathogen as M. irregularis. After admission, methylprednisolone was gradually tapered and systemic treatment with amphotericin B (total dose 615 mg) initiated along with others supportive therapies. However, the ulcers showed no improvement, and amphotericin B had to be discontinued owing to development of renal dysfunction. After extensive surgical debridement combined with VAC and skin grafting, his skin ulcers were healed; subsequent fungal cultures of the lesions were negative. The patient exhibited no signs of recurrence at 36-month follow-up. Twenty-six cases with M. irregularis-associated cutaneous mucormycosis in literature were reviewed.
C1 [Tang, Xuhua; Wong, Hioteng; Han, Jiande; Zhou, Hui] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
   [Guo, Penghao] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510080, Peoples R China.
   [Xie, Jiahui] First Peoples Hosp Shaoguan, Dept Dermatol, Shaoguan 512000, Peoples R China.
   [Xu, Yingbin] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Zhou, H (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.; Xu, YB (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burns, 58,Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
EM txh0812@126.com; jackgph@163.com; hiotengwong@outlook.com;
   xiejiahuisg@163.com; hanjd58@126.com; 333xyb@163.com;
   zhouhongcai@126.com
RI ; Zhou, Hui/JCF-2570-2023
OI Wong, Hioteng/0009-0006-4215-7155; 
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NR 34
TC 9
Z9 10
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-486X
EI 1573-0832
J9 MYCOPATHOLOGIA
JI Mycopathologia
PD JUN
PY 2021
VL 186
IS 3
BP 449
EP 459
DI 10.1007/s11046-021-00551-3
EA JUN 2021
PG 11
WC Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mycology
GA TC9CU
UT WOS:000661827200001
PM 34131870
DA 2026-07-24
ER

PT J
AU Hu, C
   Zhang, T
   Deng, Z
   Ren, B
   Cai, L
   Zhang, Y
   Yan, L
AF Hu, C.
   Zhang, T.
   Deng, Z.
   Ren, B.
   Cai, L.
   Zhang, Y.
   Yan, L.
TI Study on the effect of vacuum sealing drainage on the repair process of
   rabbit sciatic nerve injury (vol 125, pg i, 2015)
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Correction
CR Hu C, 2015, INT J NEUROSCI, V125, pI, DOI 10.3109/00207454.2015.1120699
NR 1
TC 1
Z9 1
U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0020-7454
EI 1563-5279
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PD NOV 2
PY 2015
VL 125
IS 11
BP I
EP I
DI 10.3109/00207454.2015.1120699
PG 1
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CX3DO
UT WOS:000365575900001
DA 2026-07-24
ER

PT J
AU Heuvelings, DJI
   van der Horst, J
   Pelzer, F
   Aarts, F
   Engelen, S
AF Heuvelings, Danique J. I.
   van der Horst, Jishmael
   Pelzer, Fanny
   Aarts, Frits
   Engelen, Sanne
TI Massive Localized Lymphedema, Wound Care Without Major Surgical
   Excision: A Case Report
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE maggot debridement therapy; massive localized lymphedema; obesity;
   pseudosarcoma; soft tissue tumor; wound therapy
AB Massive localized lymphedema (MLL) is a benign overgrowth of lymphoproliferative tissue that is primarily observed in adults with class III obesity. Patients present with a painless mass that has usually been present for a considerable period. Consultation of a healthcare professional typically takes place when MLL-related complaints interfere with daily living. Massive localized lymphedema is often termed "pseudosarcoma" due to its clinical similarity to sarcoma. Surgical excision is necessary to improve mobility, prevent recurrent infections, and rule out malignancy, but can be high-risk for individuals with class III obesity and multiple comorbidities. In this report, the authors present the case of a 47-year-old woman with a body mass index of 73 kg/m2 and MLL of the right medial thigh. She was successfully diagnosed and managed by local necrosectomy, wound debridement, maggot debridement therapy, and negative-pressure wound therapy by using a vacuum-assisted closure device. The diagnosis of MLL can be challenging because of its similarity to sarcoma; its pathogenesis and management are not completely elucidated. Despite surgery being the best described treatment, such an intervention itself can be challenging because patients often have multiple comorbidities and delayed diagnosis. The authors recommend that clinicians should consider nonsurgical treatment of MLL in high-risk patients who have necrotic wounds with fluid loss. The use of less invasive methods such as maggot debridement therapy followed by negative-pressure wound therapy can be useful in high-risk patients.
C1 [Heuvelings, Danique J. I.; Engelen, Sanne] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands.
   [Heuvelings, Danique J. I.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands.
   [van der Horst, Jishmael; Pelzer, Fanny; Aarts, Frits] VieCuri Med Ctr, Dept Surg, Venlo, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University
   Medical Centre (MUMC); VieCuri Medical Center
RP Heuvelings, DJI (通讯作者)，Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands.; Heuvelings, DJI (通讯作者)，Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands.
EM danique.heuvelings@maastrichtuniversity.nl;
   jischmael.vanderhorst@mumc.nl; fanny.pelzer@mumc.nl; faarts@viecuri.nl;
   sanne.engelen@mumc.nl
OI Heuvelings, Danique/0000-0001-5352-8704
CR Asch S, 2008, J AM ACAD DERMATOL, V59, pS109, DOI 10.1016/j.jaad.2008.04.009
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD NOV-DEC
PY 2024
VL 37
IS 11-12
BP 8
EP 8
DI 10.1097/ASW.0000000000000222
PG 1
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA N0V4X
UT WOS:001361608300006
PM 39792525
OA Green Published, hybrid
DA 2026-07-24
ER

PT J
AU Abarca-Buis, RF
   Munguía, NM
   Gonzalez, JMM
   Solís-Arrieta, L
   Osorio, LSY
   Krötzsch, E
AF Abarca-Buis, Rene F.
   Munguia, Nadia M.
   Melchor Gonzalez, Juan Manuel
   Solis-Arrieta, Lilia
   Saldivar y Osorio, Liliana
   Kroetzsch, Edgar
TI Silver from Polyurethane Dressing Is Delivered by Gradient to Exudate,
   Tissue, and Serum of Patients Undergoing Negative-Pressure Wound
   Treatment
SO ADVANCES IN SKIN & WOUND CARE
LA English
DT Article
DE negative-pressure wound therapy; silver dressing; wounds
ID VACUUM-ASSISTED CLOSURE; TOPICAL SILVER; ARGYRIA; SULFADIAZINE;
   SELENIUM; METALLOTHIONEIN; MICROANALYSIS; BLOOD; LIGHT
AB OBJECTIVE: This study aimed to evaluate the distribution and concentration of silver eluted from silver-coated polyurethane dressing (V.A.C. GranuFoam Silver Dressing; KCI, San Antonio, Texas) in vitro and in patients undergoing negative-pressure wound therapy (NPWT).
   DESIGN: This was a descriptive study of the effect of silver-coated polyurethane dressing in patients undergoing NPWT.
   PARTICIPANTS: Six patients with infected wounds undergoing NPWT using silver-coated polyurethane dressing.
   INTERVENTIONS: To evaluate silver release in vitro, the authors soaked dressing fragments in water and human serum for different lengths of time and performed atomic absorption spectroscopy. For patient evaluation, the authors obtained exudate, serum, and wound tissue at different time points from 6 patients undergoing NPWT and measured silver levels by atomic absorption and dispersed x-ray spectroscopy.
   MAIN RESULTS: Silver from the dressing was immediately released in vitro at a rate 3 times greater in serum than in water. In vivo, silver was delivered to wound exudate at rates 102 to 104 times greater than in corresponding serum. Few surface silver deposits were detected in treated tissue.
   CONCLUSION: The high concentration of silver found in wound exudate reflects not only the affinity for silver in serum components and wound fluids, but also that most silver ions are not distributed systemically in the patient; instead, they are transported by the vacuum created by therapy.
C1 [Abarca-Buis, Rene F.; Kroetzsch, Edgar] Inst Nacl Rehabil, Ctr Nacl Invest & Atenc Quemados, Lab Connect Tissue, Mexico City, DF, Mexico.
   [Munguia, Nadia M.; Saldivar y Osorio, Liliana] Univ Nacl Autonoma Mexico, Fac Quim, Dept Analyt Chem, Mexico City 04510, DF, Mexico.
   [Melchor Gonzalez, Juan Manuel] Inst Seguridad Social Estado Mexico & Municipios, Dept Plast Surg, Mexico City, DF, Mexico.
   [Solis-Arrieta, Lilia] Inst Nacl Rehabil, Lab Elect Microscopy, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Abarca-Buis, RF (通讯作者)，Inst Nacl Rehabil, Ctr Nacl Invest & Atenc Quemados, Lab Connect Tissue, Mexico City, DF, Mexico.
RI Krötzsch, Edgar/ABG-2017-2021
OI Krötzsch, Edgar/0000-0002-0696-0147; Abarca-Buis, René
   Fernando/0000-0003-3372-813X
CR Aoyagi H, 2008, DENT MATER J, V27, P612, DOI 10.4012/dmj.27.612
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NR 37
TC 11
Z9 11
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-7941
EI 1538-8654
J9 ADV SKIN WOUND CARE
JI Adv. Skin Wound Care
PD APR
PY 2014
VL 27
IS 4
BP 156
EP 162
DI 10.1097/01.ASW.0000444849.71374.bc
PG 7
WC Dermatology; Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology; Nursing; Surgery
GA AI2ZK
UT WOS:000336727500003
PM 24637649
DA 2026-07-24
ER

PT J
AU Lindstedt, S
   Ingemansson, R
   Malmsjö, M
AF Lindstedt, Sandra
   Ingemansson, Richard
   Malmsjo, Malin
TI Sternum wound contraction and distension during negative pressure wound
   therapy when using a rigid disc to prevent heart and lung rupture
SO JOURNAL OF CARDIOTHORACIC SURGERY
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; POSTSTERNOTOMY MEDIASTINITIS
AB Background: There are increasing reports of deaths and serious complications associated with the use of negative pressure wound therapy (NPWT), of which right ventricular heart rupture is the most devastating. The use of a rigid barrier has been suggested to offer protection against this lethal complication by preventing the heart from being drawn up against the sharp edges of the sternum. The aim of the present study was to determine whether a rigid barrier can be safely inserted over the heart with regard to the sternum wound edge movement.
   Methods: Sternotomy wounds were created in eight pigs. The wounds were treated with NPWT at -40, -70, -120 and -170 mmHg in the presence and absence of a rigid barrier between the heart and the edges of the sternum. Wound contraction upon NPWT application, and wound distension under mechanical traction to draw apart the edges of the sternotomy were evaluated.
   Results: Wound contraction resulting from NPWT was similar with and without the rigid barrier. When mechanical traction was applied to a NPWT treated sternum wound, the sternal edges were pulled apart. Wound distension upon traction was similar in the presence and absence of a the rigid barrier during NPWT.
   Conclusions: A rigid barrier can safely be inserted between the heart and the edges of the sternum to protect the heart and lungs from rupture during NPWT. The sternum wound edge is stabilized equally well with as without the rigid barrier during NPWT.
C1 [Lindstedt, Sandra; Ingemansson, Richard] Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
   [Lindstedt, Sandra; Ingemansson, Richard; Malmsjo, Malin] Skane Univ Hosp, Lund, Sweden.
   [Malmsjo, Malin] Lund Univ, Dept Ophthalmol, Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University
RP Lindstedt, S (通讯作者)，Lund Univ, Dept Cardiothorac Surg, Lund, Sweden.
EM sandra.lindstedt@skane.se
RI ; Lindstedt, Sandra/AEM-2892-2022
OI Ingemansson, Richard/0000-0001-7623-8953; Lindstedt,
   Sandra/0000-0003-4484-6473; Maljö, Malin/0000-0001-9849-9599
FU Swedish Medical Research Council; Lund University Faculty of Medicine;
   Swedish Government; Lund University Hospital; Swedish Medical
   Association; Royal Physiographic Society in Lund; Ake Wiberg Foundation;
   Anders Otto Sward Foundation/Ulrika Eklund Foundation; Magn Bergvall
   Foundation; Crafoord Foundation; Anna-Lisa and Sven-Erik Nilsson
   Foundation; Jeansson Foundation; Swedish Heart-Lung Foundation; Anna and
   Edvin Berger's Foundation; Marta Lundqvist Foundation; Lars Hierta's
   Memorial Foundation
FX This study was supported by the Swedish Medical Research Council, Lund
   University Faculty of Medicine, the Swedish Government Grant for
   Clinical Research, Lund University Hospital Research Grants, the Swedish
   Medical Association, the Royal Physiographic Society in Lund, the Ake
   Wiberg Foundation, the Anders Otto Sward Foundation/Ulrika Eklund
   Foundation, the Magn Bergvall Foundation, the Crafoord Foundation, the
   Anna-Lisa and Sven-Erik Nilsson Foundation, the Jeansson Foundation, the
   Swedish Heart-Lung Foundation, Anna and Edvin Berger's Foundation, the
   Marta Lundqvist Foundation, and Lars Hierta's Memorial Foundation.
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NR 17
TC 4
Z9 4
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1749-8090
J9 J CARDIOTHORAC SURG
JI J. Cardiothorac. Surg.
PD MAR 30
PY 2011
VL 6
AR 42
DI 10.1186/1749-8090-6-42
PG 6
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA 747YA
UT WOS:000289356000001
PM 21450095
OA Green Submitted, gold
DA 2026-07-24
ER

PT J
AU Wild, T
   Stremitzer, S
   Budzanowski, A
   Hoelzenbein, T
   Ludwig, C
   Ohrenberger, G
AF Wild, Thomas
   Stremitzer, Stefan
   Budzanowski, Annita
   Hoelzenbein, Thomas
   Ludwig, Claudia
   Ohrenberger, Gerald
TI Definition of efficiency in vacuum therapy - a randomised controlled
   trial comparing Redon drains with VAC® Therapy™
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Pressure ulcer; Redon bottles; Vacuum-assisted closure (VAC)
AB Redon drains are still used to suction wounds for vacuum sealing. Vacuum-assisted closure (V.A.C.(R); Kinetic Concepts Inc, San Antonio, TX) is a computer-controlled therapy system for delivering topical negative pressure therapy. The efficiency of V. A. C. in the treatment of pressure ulcers was prospectively studied in a randomised controlled trial in which patients with pressure ulcers were randomly assigned to negative pressure wound therapy (NPWT) using either V. A. C. or Redon bottles. The target parameters were absolute and relative proportion of wound area consists of granulation tissue, fibrin and necrosis. Other outcome measures were the number of dressing changes and time invested using each system. The study was terminated after a post hoc analysis after inclusion of ten patients because of the significantly better results when using V. A. C., and the substantially larger care effort needed in the Redon group compared with the V. A. C. group. An increase in surface granulation tissue of 54% was observed in the V. A. C. group, and a reduction in the Redon group (P = 0.001). The Redon group showed an increase in fibrin tissue at the wound base of 21.8%, whereas in the V. A. C group, a 27% reduction was observed (P = 0.035). Necrosis was reduced in the V. A. C. group, but this difference did not reach significance. Redon bottles are not a good alternative for V. A. C. therapy for delivering NPWT.
C1 [Wild, Thomas; Stremitzer, Stefan; Budzanowski, Annita] Med Univ Vienna, Dept Gen Surg, A-1090 Vienna, Austria.
   [Hoelzenbein, Thomas] Med Univ Vienna, Dept Vasc Surg, A-1090 Vienna, Austria.
   [Ludwig, Claudia; Ohrenberger, Gerald] Geriatr Ctr Haus der Barmherzigkeit, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna
RP Wild, T (通讯作者)，Med Univ Vienna, Dept Gen Surg, Spitalgasse 23, A-1090 Vienna, Austria.
EM thomas.wild@meduniwien.ac.at
FU National Grant OENBF [10865]
FX This project was supported by National Grant OENBF 10865.
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NR 26
TC 24
Z9 32
U1 0
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-4801
J9 INT WOUND J
JI Int. Wound J.
PD DEC
PY 2008
VL 5
IS 5
BP 641
EP 647
DI 10.1111/j.1742-481X.2007.00407.x
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA V16BF
UT WOS:000207844400008
PM 19134065
OA Green Submitted, Bronze
DA 2026-07-24
ER

PT J
AU Armstrong, DG
   Marston, WA
   Reyzelman, AM
   Kirsner, RS
AF Armstrong, David G.
   Marston, William A.
   Reyzelman, Alexander M.
   Kirsner, Robert S.
TI Comparison of negative pressure wound therapy with an ultraportable
   mechanically powered device vs. traditional electrically powered device
   for the treatment of chronic lower extremity ulcers: A multicenter
   randomized-controlled trial
SO WOUND REPAIR AND REGENERATION
LA English
DT Article
ID VACUUM-ASSISTED CLOSURE; DIABETIC FOOT ULCERS; SYSTEM; STATE; CARE
AB The purpose of this study was to compare the ultraportable mechanically powered Smart Negative Pressure (SNaP(R)) Wound Care System to the traditional electrically powered Vacuum-Assisted Closure (VAC(R)) Therapy System in the treatment of chronic lower extremity wounds. This 12-center randomized-controlled trial of patients with noninfected, nonischemic, nonplantar lower extremity wounds had enrolled 65 patients, as of January 5, 2010, at the time of a planned interim analysis. Subjects were randomly assigned to treatment with either the SNaP(R) or VAC(R) Systems. The trial evaluated treatment for up to 16 weeks or till complete closure was achieved. Fifty-three patients (N527 SNaP(R), N526 VAC(R)) completed at least 4 weeks of therapy. Thirty-three patients (N518 SNaP(R), N515 VAC(R)) completed the study with either healing or 16 weeks of therapy. At the time of planned interim analysis, no significant differences (p=0.99) in the proportion of subjects healed between the two devices evaluated were found. In addition, the percent wound size reduction between treatment groups was not significantly different at 4, 8, 12, and 16 weeks, with noninferiority analysis at 4 weeks of treatment reaching the p-value <0.05 significance level (*p=0.019). These interim data suggest no difference in wound closure between the SNaP(R) System and the VAC(R) System in the population studied. We look forward to the final analysis results.
C1 [Armstrong, David G.] Univ Arizona, Coll Med, SALSA, Tucson, AZ 85721 USA.
   [Marston, William A.] Univ N Carolina, Div Vasc Surg, Dept Surg, Sch Med, Chapel Hill, NC USA.
   [Reyzelman, Alexander M.] Samuel Merritt Univ, Dept Med, Calif Sch Podiatr Med, Oakland, CA USA.
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C3 University of Arizona; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   Samuel Merritt University; University of Miami
RP Armstrong, DG (通讯作者)，Univ Arizona, Coll Med, SALSA, Tucson, AZ 85721 USA.
EM armstrong@usa.net
FU Spiracur Inc.; Spiracur; K.C.I.
FX This study was sponsored by a grant from Spiracur Inc., manufacturer of
   the SnAP(R) device. Two authors (Drs. Armstrong and Marston) have
   received research funding from both Spiracur and K.C.I.
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NR 19
TC 24
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1067-1927
EI 1524-475X
J9 WOUND REPAIR REGEN
JI Wound Repair Regen.
PD MAR-APR
PY 2011
VL 19
IS 2
BP 173
EP 180
DI 10.1111/j.1524-475X.2010.00658.x
PG 8
WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery
GA 728ML
UT WOS:000287878100226
PM 21362084
DA 2026-07-24
ER

PT J
AU Ford, SJ
   Rathinam, S
   King, JE
   Vaughan, R
AF Ford, SJ
   Rathinam, S
   King, JE
   Vaughan, R
TI Tuberculous osteomyelitis of the sternum: Successful management with
   debridement and vacuum assisted closure
SO EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
LA English
DT Article
DE sternal osteomyetitis; vacuum assisted closure; tuberculosis
ID FLAP
AB Primary Mycobacterial infection of the sternum is an exceedingly rare occurrence. We present a case of tuberculous osteomyelitis of the sternum successfully treated with surgical debridement and vacuum-assisted closure therapy. (c) 2005 Elsevier B.V. All rights reserved.
C1 Birmingham Heartlands Hosp, Reg Dept Thorac Surg, Birmingham B9 5SS, W Midlands, England.
C3 Heart of England NHS Foundation Trust; Heartlands Hospital; University
   of Birmingham
RP Rathinam, S (通讯作者)，Birmingham Heartlands Hosp, Reg Dept Thorac Surg, Bardesley Green E, Birmingham B9 5SS, W Midlands, England.
EM srathinam@rcsed.ac.uk
OI Ford, Samuel/0000-0002-1739-964X; vaughan, roger/0000-0001-6066-4595
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NR 8
TC 15
Z9 18
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1010-7940
EI 1873-734X
J9 EUR J CARDIO-THORAC
JI Eur. J. Cardio-Thorac. Surg.
PD OCT
PY 2005
VL 28
IS 4
BP 645
EP 647
DI 10.1016/j.ejcts.2005.05.030
PG 3
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 974GX
UT WOS:000232580500028
PM 16179195
DA 2026-07-24
ER

EF