TCM-Ingredient-Target result summary
====================================

Hub gene: MMP1

1. Dataset overview
-------------------
      Dataset Records Drugs Ingredients Targets MMP1_records MMP1_drugs MMP1_ingredients
1 Significant     561    99          14       5          156         96                4
2  AllMatched    1151   257          18       5          298        236                7


2. Target frequency in significant result
-----------------------------------------
  Target   n
1   MMP1 156
2  CHEK1 120
3  MMP13 102
4  MKI67 100
5  TRPV2  83


3. MMP1-related ingredients in significant result
-------------------------------------------------
  Ingredient  n
1  Quercetin 83
2   Luteolin 62
3  Berberine 10
4 senkirkine  1


4. Top selected candidate TCM herbs from significant result
-----------------------------------------------------------
# A tibble: 20 × 8
    Rank Drug           priority_score n_ingredients n_targets mmp1_ingredients mmp1_ingredient_list targets                         
   <int> <chr>                   <dbl>         <int>     <int>            <dbl> <chr>                <chr>                           
 1     1 Guanhuangbo                38             4         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
 2     2 Mahuang                    38             4         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
 3     3 Niuxi                      38             4         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
 4     4 Baixianpi                  37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
 5     5 Banzhilian                 37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
 6     6 Dazao                      37             3         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
 7     7 Huangbo                    37             3         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
 8     8 Huanglian                  37             3         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
 9     9 Juhua                      37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
10    10 Lianqiao                   37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
11    11 Machixian                  37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
12    12 Wuzhuyu                    37             3         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
13    13 Yanhusuo                   37             3         5                2 Berberine; Quercetin CHEK1; MKI67; MMP1; MMP13; TRPV2
14    14 Zeqi                       37             3         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
15    15 Baijiangcao                36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
16    16 Bajiaohuixiang             36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
17    17 Banbianlian                36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
18    18 Bianxu                     36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
19    19 Chuipencao                 36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2
20    20 Dengzhanxixin              36             2         5                2 Luteolin; Quercetin  CHEK1; MKI67; MMP1; MMP13; TRPV2


5. Recommended interpretation
-----------------------------
The current result suggests that MMP1 is a central hub target in the drug-ingredient-target network.
The strongest MMP1-related active ingredients are mainly quercetin, luteolin, and berberine.
Herbs containing two or more MMP1-related core ingredients and covering both MMP1 and MMP13 are more suitable for downstream validation.
For OA/cartilage degeneration studies, the MMP1-MMP13 extracellular matrix degradation axis can be used as the main mechanistic line.
CHEK1, MKI67, and TRPV2 may be used as secondary targets related to cell stress, proliferation, and ion-channel/inflammatory responses.
