Melinda K. Duncan

Department of Biological Sciences, University of Delaware

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2023

Other Publications

Article	Year
Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes. Molecular and cellular biology\| PubMed ID: 9710641	1998
Truncated forms of Pax-6 disrupt lens morphology in transgenic mice. Investigative ophthalmology & visual science\| PubMed ID: 10670477	2000
Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression. Journal of cell science\| PubMed ID: 10954416	2000
Prox1 is differentially localized during lens development. Mechanisms of development\| PubMed ID: 11850194	2002
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. Transgenic research\| PubMed ID: 12212842	2002
Collagen IV in the developing lens capsule. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 12225806	2002
A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 12485166	2002
Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens. Experimental eye research\| PubMed ID: 12634108	2003
Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression. The Journal of biological chemistry\| PubMed ID: 14707122	2004
Developmental expression of Pop1/Bves. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 14966204	2004
Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1. Molecular and cellular biology\| PubMed ID: 15082770	2004
OptiRNAi, an RNAi design tool. Computer methods and programs in biomedicine\| PubMed ID: 15158049	2004
Ectopic Pax6 expression disturbs lens fiber cell differentiation. Investigative ophthalmology & visual science\| PubMed ID: 15452066	2004
Palm is expressed in both developing and adult mouse lens and retina. BMC ophthalmology\| PubMed ID: 15969763	2005
JAM-A expression during embryonic development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15977176	2005
Expression of tissue plasminogen activator during eye development. Experimental eye research\| PubMed ID: 15978259	2005
Production of monoclonal antibodies against Prox1. Hybridoma (2005)\| PubMed ID: 16475879	2006
Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin. The EMBO journal\| PubMed ID: 16675956	2006
Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens. Investigative ophthalmology & visual science\| PubMed ID: 17065509	2006
Deletion of JAM-A causes morphological defects in the corneal epithelium. The international journal of biochemistry & cell biology\| PubMed ID: 17118692	2007
Subfertility in mice harboring a mutation in betaB2-crystallin. Molecular vision\| PubMed ID: 17392687	2007
Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Developmental biology\| PubMed ID: 17493607	2007
Genetic and epigenetic mechanisms of gene regulation during lens development. Progress in retinal and eye research\| PubMed ID: 17905638	2007
Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion. Cancer research\| PubMed ID: 18381425	2008
Dual roles for Prox1 in the regulation of the chicken betaB1-crystallin promoter. Investigative ophthalmology & visual science\| PubMed ID: 18385074	2008
Differential expression of the HMGN family of chromatin proteins during ocular development. Gene expression patterns : GEP\| PubMed ID: 18502697	2008
The lens capsule. Experimental eye research\| PubMed ID: 18773892	2009
Contributions of mouse genetic background and age on anterior lens capsule thickness. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 18951502	2008
PCNA interacts with Prox1 and represses its transcriptional activity. Molecular vision\| PubMed ID: 19023449	2008
CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury. Differentiation; research in biological diversity\| PubMed ID: 19853364	2010
Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. The Journal of biological chemistry\| PubMed ID: 19858219	2009
Characterizing molecular diffusion in the lens capsule. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 20026402	2010
Focus on molecules: Smad Interacting Protein 1 (Sip1, ZEB2, ZFHX1B). Experimental eye research\| PubMed ID: 20868684	2012
Unfolded Protein Response (UPR) is activated during normal lens development. Gene expression patterns : GEP\| PubMed ID: 21044701	2011
Expression of βA3/A1-crystallin in the developing and adult rat eye. Journal of molecular histology\| PubMed ID: 21203897	2011
Development. A new focus on RNA in the lens. Science (New York, N.Y.)\| PubMed ID: 21436425	2011
aV integrins and TGF-β-induced EMT: a circle of regulation. Journal of cellular and molecular medicine\| PubMed ID: 21883891	2012
The unfolded protein response is activated in connexin 50 mutant mouse lenses. Experimental eye research\| PubMed ID: 22713599	2012
Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PloS one\| PubMed ID: 23667656	2013
Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mechanisms of development\| PubMed ID: 24161570	2013
The roles of αV integrins in lens EMT and posterior capsular opacification. Journal of cellular and molecular medicine\| PubMed ID: 24495224	2014
Lens extrusion from Laminin alpha 1 mutant zebrafish. TheScientificWorldJournal\| PubMed ID: 24526906	2014
Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells. The international journal of biochemistry & cell biology\| PubMed ID: 24607497	2014
The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery. Investigative ophthalmology & visual science\| PubMed ID: 25082886	2014
Development of novel filtering criteria to analyze RNA-sequencing data obtained from the murine ocular lens during embryogenesis. Genomics data\| PubMed ID: 25478318	2014
Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 26590164	2016
Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression. Development (Cambridge, England)\| PubMed ID: 26657765	2016
The molecular mechanisms underlying lens fiber elongation. Experimental eye research\| PubMed ID: 27015931	2017
β1-integrin controls cell fate specification in early lens development. Differentiation; research in biological diversity\| PubMed ID: 27596755	2016
Intravitreal methotrexate infusion for proliferative vitreoretinopathy. Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 27698550	2016
β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis. Investigative ophthalmology & visual science\| PubMed ID: 28763805	2017
Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO). Experimental eye research\| PubMed ID: 29932883	2018
Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery. Investigative ophthalmology & visual science\| PubMed ID: 30326070	2018
Cataract surgeon viewpoints on the need for novel preventative anti-inflammatory and anti-posterior capsular opacification therapies. Current medical research and opinion\| PubMed ID: 31328581	2019
A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus. Scientific reports\| PubMed ID: 31371771	2019
Fibronectin has multifunctional roles in posterior capsular opacification (PCO). Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 32173580	2020
Morphometric analysis of the lens in human aniridia and mouse Small eye. Experimental eye research\| PubMed ID: 33248069	2021
A simple method for quantitating confocal fluorescent images. Biochemistry and biophysics reports\| PubMed ID: 33553685	2021
The aging mouse lens transcriptome. Experimental eye research\| PubMed ID: 34119483	2021
The effect of sex on the mouse lens transcriptome. Experimental eye research\| PubMed ID: 34146586	2021
αVβ8 integrin targeting to prevent posterior capsular opacification. JCI insight\| PubMed ID: 34554928	2021
The Immediate Early Response of Lens Epithelial Cells to Lens Injury. Cells\| PubMed ID: 36359852	2022
ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment. Cells\| PubMed ID: 37998373	2023