< Back to Core

Chapter 22

Drugs Affecting Gastrointestinal Motility

Chapter 22

Drugs Affecting Gastrointestinal Motility

Physiology of Enteric Nervous System and Gut Health
The gastrointestinal tract is protected by the barrier, comprising secretory, physical, and immune components. The secretory barrier comprises the mucus …
Enteric Nervous System: Regulation of GI Motor Activity
Gastrointestinal or GI motor activity is primarily regulated by the enteric nervous system or ENS, a complex network of nerves embedded within the gut …
Gastrointestinal Motility Disorders
Gastrointestinal, or GI motility disorders, are a group of conditions characterized by irregular movements within the GI tract, resulting from damage to …
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Dopamine, a neurotransmitter abundant in the gastrointestinal or GI tract, is involved in GI motility. It binds to D2 receptors, lowering intragastric …
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Serotonin, also known as 5-Hydroxytryptamine or 5-HT, is a neurotransmitter crucial for regulating gut motility. Within the GI tract, enterochromaffin …
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
Laxatives accelerate bowel movements, alleviating constipation. They increase intestinal water content, stimulate intestinal contractions, or lubricate …
Drugs Affecting GI Tract Motility: Other Laxatives
Recall that laxatives facilitate coordinated gut movement or change stool's consistency to relieve constipation. Stool softeners, such as docusate …
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Diarrhea is characterized by increased gut motility and secretion of water and electrolytes, leading to frequent loose stools. It may be caused by viral …
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Diarrhea, characterized by frequent bowel movements, can lead to complications such as dehydration and electrolyte imbalance. It is primarily caused by …
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
Acute diarrhea is characterized by the rapid evacuation of watery stools. It is primarily caused by pathogens such as bacteria, viruses, or protozoa. This …
Gastrointestinal Motility Monitor (GIMM)
The Gastrointestinal Motility Monitor (GIMM; Catamount Research and Development; St. Albans, VT) is an in vitro system that monitors propulsive motility …
Measuring Constipation in a Drosophila Model of Parkinson’s Disease
Non-motor symptoms in Parkinson’s disease (PD) are common, difficult to treat, and significantly impair quality of life. One prevalent non-motor symptom …
Fecal Deposit Analysis of Drosophila for the Assessment of Antidiarrheal Drugs and Plant Extracts
To study human gastrointestinal physiology, biomedical scientists have relied on the use of model organisms. Although many researchers have used mice as a …