Chapter 23
Drugs for Chronic Bowel Disorders
Chapter 23
Drugs for Chronic Bowel Disorders
Chronic bowel disorders are long-term medical conditions affecting the digestive tract, including disorders such as irritable bowel syndrome or IBS and …
Diarrhea-predominant irritable bowel syndrome or IBS-D, is characterized by chronic abdominal pain and diarrhea.
Effective IBS-D management involves …
Irritable bowel syndrome with constipation or IBS-C, is a recurring digestive disorder characterized by abdominal pain and infrequent bowel movements.
…
Ulcerative colitis is characterized by mucosal inflammation of the colon.
The first-line agent, 5-aminosalicylic acid or 5-ASA, inhibits leukotriene and …
Crohn's disease is an inflammatory bowel disorder characterized by discontinuous chronic inflammation of the GI tract.
Treatment strategies encompass …
Tumor necrosis factor, or TNF, a proinflammatory cytokine, exists in soluble or membrane-bound form.
TNF-receptor interaction triggers NF-κB, T-cell …
Glucocorticoids, like prednisone, are potent anti-inflammatory agents that induce effective remission in Crohn's patients.
These bind and activate …
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic relapsing disorders of the intestines. They cause …
Gut homing of immune cells is important for the pathogenesis of inflammatory bowel diseases (IBD). Integrin-dependent cell adhesion to addressins is a …
Significant studies have been carried out to understand effective management of intestinal fibrosis. However, the lack of better knowledge of fibrosis has …