Nonlinear Pharmacokinetics

Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow …

Various factors contribute to nonlinearity in drug pharmacokinetics. Nonlinearity in drug absorption may result from rate-limited solubility, …

The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism. It determines the rate of decline of drug concentration over time, …

The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration. …

In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM. Following an IV bolus, Dt, the amount of drug in the body at any …

Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes. The metabolism of drugs …

Drugs administered through different administration routes follow nonlinear elimination. Consider a drug administered through a constant IV infusion, …

Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics. The elimination half-life is influenced by the …

Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions. Standard circadian …

Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical. Cyclic changes occur over constant …

For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate. A saturable pathway …

Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution. These cellular transporters in cells modulate …