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The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
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August 18, 2011
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The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.
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Richner, M., Bjerrum, O. J., Nykjaer, A., Vaegter, C. B. The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice. J. Vis. Exp. (54), e3092, doi:10.3791/3092 (2011).
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