Misr International University 1 article published in JoVE Biochemistry An Integrated Raman Spectroscopy and Mass Spectrometry Platform to Study Single-Cell Drug Uptake, Metabolism, and Effects Ahmed Ali1,2, Yasmine Abouleila1,2, Arno Germond1 1Biodynamics Research Center (BDR), RIKEN, 2Research Center, Misr International University This protocol presents an integrated Raman spectroscopy-mass spectrometry (MS) platform that is capable of achieving single-cell resolution. Raman spectroscopy can be used to study cellular response to drugs, while MS can be used for targeted and quantitative analysis of drug uptake and metabolism.
