Yerevan State Medical University 2 articles published in JoVE Bioengineering A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy Pooja H. Chainani1,2, Patrick M. Williamson1,2, Diana Yeritsyan1, Kaveh Momenzadeh1, Nadim Kheir1, Joseph P. DeAngelis1,3, Arun J. Ramappa1,3, Ara Nazarian1,2,3,4 1Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 2Mechanical Engineering Department, Boston University, 3Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 4Department of Orthopaedic Surgery, Yerevan State Medical University This protocol presents a testing system used to induce quantifiable and controlled fatigue injuries in a rat Achilles tendon for an in-vivo model of overuse-induced tendinopathy. The procedure consists of securing the rat's ankle to a joint actuator that performs passive ankle dorsiflexion with a custom-written MATLAB script. Bioengineering Rat Model of Adhesive Capsulitis of the Shoulder Stephen M. Okajima*1, M. Belen Cubria*1, Sharri J. Mortensen1, Juan C. Villa-Camacho1, Philip Hanna1, Aron Lechtig1, Miguel Perez-Viloria1, Patrick Williamson1, Mark W. Grinstaff*3, Edward K. Rodriguez*2, Ara Nazarian*1,4 1Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, 2Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, 3Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, 4Department of Orthopaedic Surgery, Yerevan State Medical University This protocol presents an in vivo rat model of adhesive capsulitis. The model includes an internal fixation of the glenohumeral joint with extra-articular suture fixation for an extended time, resulting in a decreased rotational range of motion (ROM) and increased joint stiffness.
