OIE Reference Lab for Swine Streptococcosis 1 article published in JoVE Immunology and Infection Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model Shouming Zhang1,2,3, Xueping Gao1,2,3, Genhui Xiao1,2,3,4, Chengping Lu1,2,3, Huochun Yao1,2,3, Hongjie Fan1,2,3,5, Zongfu Wu1,2,3 1College of Veterinary Medicine, Nanjing Agricultural University, 2Key Lab of Animal Bacteriology, Ministry of Agriculture, 3OIE Reference Lab for Swine Streptococcosis, 4School of Medicine, Tsinghua University, 5Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Here, we describe the intracranial subarachnoidal route of infection in mice to study roles of biofilms in Streptococcus suis meningitis. This infection model is also suitable for studying the pathogenesis of other bacterial meningitis and the efficacy of new drugs against bacterial meningitis.
