Sichuan University and Collaborative Innovation Center 3 articles published in JoVE Immunology and Infection Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model Yuanfan Qian1,2, Linye He1,2, Anping Su1,2, Yiguo Hu3, Jingqiang Zhu1 1Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University, 2The Laboratory of Thyroid and Parathyroid Disease, West China Hospital of Sichuan University, 3State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center Several types of animal models of Hashimoto's thyroiditis have been established, as has spontaneous autoimmune thyroiditis in the NOD mouse. H-2h4 mice are a simple and reliable model for HT induction. This article describes this approach and evaluates the pathological process for a better understanding of the SAT murine model. Cancer Research Spontaneous Murine Model of Anaplastic Thyroid Cancer Huayun Yan1, Yingfang Ma1, Xinyue Zhou2, Yushuang He3, Yang Liu2, Carlos Caulin4, Leiming Wang5, Heng Xu1,6, Han Luo2,6 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, 2Division of Thyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, Department of General Surgery, West China Hospital, Sichuan University, 3Department of Ultrasound, West China Hospital of Sichuan University, Sichuan University, 4Department of Otolaryngology-Head & Neck Surgery and University of Arizona Cancer Center, University of Arizona, 5Center for Translational Medicine, Shenzhen Bay Laboratory, 6Division of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University Here, we present a standard pipeline to obtain murine ATC tumors by spontaneous genetically engineered mouse models. Further, we present tumor dynamics and pathological information about the primary and metastasized lesions. This model will help researchers to understand tumorigenesis and facilitate drug discoveries. Cancer Research High-Resolution Ultrasonography for the Analysis of Orthotopic ATC Tumors in a Genetically Engineered Mouse Model Yushuang He1, Yan Luo1, Zhihui Li2, Han Luo2, Huayun Yan3, Yingfang Ma3, Xinyue Zhou2 1Department of Ultrasound, West China Hospital, Sichuan University, 2Department of Thyroid and Parathyroid Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 3State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center The present protocol describes high-frequency ultrasonography for visualizing the entire mouse thyroid gland and monitoring the growth of anaplastic thyroid carcinoma.
