International University of Health and Welfare Mita Hospital 1 article published in JoVE Medicine Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium Takuya Hashimoto1,2,3, Kota Yamamoto1,2,3, Trenton Foster1, Hualong Bai1, Kunihiro Shigematsu4, Alan Dardik1,3 1Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University, 2Department of Vascular Surgery, University of Tokyo, 3Department of Vascular Surgery, VA Connecticut Healthcare Systems, 4Department of Vascular Surgery, International University of Health and Welfare Mita Hospital After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
