University of Haifa View Institution's Website 1 article published in JoVE Medicine An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth Dalit Barkan1, Jeffrey E. Green2 1Department of Biology, University of Haifa, 2Transgenic Oncogenesis and Genomics Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute A modified 3-D in vitro system is presented in which growth characteristics of several tumor cell lines in reconstituted basement membrane correlate with the dormant or proliferative behavior of the tumor cells at a metastatic secondary site in vivo.