Kyoto University Graduate School of Biostudies 1 article published in JoVE Developmental Biology Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis Hiromi Shimojo1, Ryoichiro Kageyama1,2,3,4 1Institute for Frontier Life and Medical Sciences, Kyoto University, 2Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, 3Kyoto University Graduate School of Medicine, 4Kyoto University Graduate School of Biostudies Neural stem/progenitor cells exhibit various expression dynamics of Notch signaling components that lead to different outcomes of cellular events. Such dynamic expression can be revealed by real-time monitoring, not by static analysis, using a highly sensitive bioluminescence imaging system that enables visualization of rapid changes in gene expressions.
