Kyunghee Naseul Korean Medicine Clinic 1 article published in JoVE Medicine Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model Se-Eun Lee*1, Chiyeon Lim*2, Minji Lee1, Chang-Hyun Kim2, Hyungwoo Kim1, Byoungho Lee3, Suin Cho1 1School of Korean Medicine, Pusan National University, 2College of Medicine, Dongguk University, 3Kyunghee Naseul Korean Medicine Clinic In this study, we modify an existing experimental method to obtain more reproducible results, by establishing a middle cerebral artery occlusion (MCAO) mouse model. Oral administration of Glycyrrhizae Radix et Rhizome (GR) methanol extract (GRex), following stroke induction, significantly decreased total infarction volume relative to the untreated control group.
