Ingham Institute for Applied Medical Research 1 article published in JoVE Cancer Research An Orthotopic Resectional Mouse Model of Pancreatic Cancer Tony C. Y. Pang1,2,4,5, Zhihong Xu1,2, Alpha Raj Mekapogu1,2, Srinivasa Pothula1,2, Therese M. Becker3, David Goldstein1, Romano C. Pirola1,2, Jeremy S. Wilson1,2, Minoti V. Apte1,2 1Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, 2Ingham Institute for Applied Medical Research, 3Centre for Circulating Tumour Cell Diagnostics and Research, Ingham Institute for Applied Medical Research, 4Surgical Innovations Unit, Westmead Hospital, 5Westmead Clinical School, University of Sydney In the clinical context, patients with localized pancreatic cancer will undergo pancreatectomy followed by adjuvant treatment. This protocol reported here aims to establish a safe and effective method of modelling this clinical scenario in nude mice, through orthotopic implantation of pancreatic cancer followed by distal pancreatectomy and splenectomy.
