Liverpool Hospital 1 article published in JoVE Medicine Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model Dinesh Selvakumar*1,2, Emma Wilkie*1, Tejas Deshmukh1,2, Dhanya Ravindran1, Yasuhito Kotake2, Juntang Lu2, Tony Barry2, Vu Tran2, Hugh Paterson3, Alfred Hing4, Timothy Campbell2, Saurabh Kumar2, Eddy Kizana1,2, James J. H. Chong1,2 1Centre for Heart Research, The Westmead Institute for Medical Research, The University of Sydney, 2Department of Cardiology, Westmead Hospital, 3Sydney Imaging, Core Research Facility, The University of Sydney, 4Department of Cardiothoracic Surgery, Liverpool Hospital The present protocol describes three methods of administering cardioactive therapeutic agents in a porcine model. Female landrace swine received treatment through either: (1) thoracotomy and transepicardial injection, (2) catheter-based transendocardial injection, or (3) intravenous infusion via jugular vein osmotic minipump.
