2 articles published in JoVE
Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography Rebecca Lim1,2, Marcus J. Zavou1, Phillipa-Louise Milton3, Siow Teng Chan1, Jean L. Tan1, Hayley Dickinson1,2, Sean V. Murphy4, Graham Jenkin1,2, Euan M. Wallace1,2 1The Ritchie Centre, Monash Institute of Medical Research, 2Department of Obstetrics and Gynaecology, Monash Medical Centre, 3Animal Resource Centre, Perth, Australia, 4Wake Forest Institute for Regenerative Medicine The assessment of respiratory physiology has traditionally relied upon techniques, which require restraint or sedation of the animal. Unrestrained whole-body plethysmography, however, provides precise, non-invasive, quantitative analysis of respiratory physiology in animal models. In addition, the technique allows repeated respiratory assessment of mice allowing for longitudinal studies.
A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice Jacqueline F. Donoghue1, Oliver Bogler2, Terrance G. Johns1 1Monash Institute of Medical Research, 2MD Anderson Cancer Centre, University of Texas In order to evaluate novel therapeutic paradigms for the treatment of glioma, physiological relevant models are essential. We utilize an implantable guide screw procedure for establishment of intracranial xenograft models that is more rapid and safer than stereotactic approaches.