2 articles published in JoVE
Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents Mojtaba Kermani*1,3, Zahra Fatahi*2, Dechuan Sun3, Abbas Haghparast2, Chris French3,4 1Department of Optometry and Vision Science, The University of Melbourne, 2Neuroscience Research Center, Shahid Beheshti University of Medical Science, 3Department of Medicine, The University of Melbourne, 4Royal Melbourne Hospital A cost-benefit analysis is a weighing-scale approach that the brain performs during the course of decision making. Here, we propose a protocol to train rats on an operant-based decision-making paradigm where rats choose higher rewards at the expense of waiting for 15 s to receive them.
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data Tim Spelman1,2, Orla Gray3, Robyn Lucas4, Helmut Butzkueven1,2 1Department of Neurology, Royal Melbourne Hospital, 2Department of Medicine (RMH), The University of Melbourne, 3Department of Neurology, Ulster Hospital, 4National Centre for Epidemiology and Population Health, Australian National University Combining plot analysis with trigonometric regression is a robust method for exploring complex, cyclical phenomena such as relapse onset timing in multiple sclerosis (MS). This method enabled unbiased characterisation of seasonal trends in relapse onset permitting novel inferences around the influence of seasonal variation, ultraviolet radiation (UVR) and latitude.