Institute for Atmospheric and Climate Science ETH Zurich 1 article published in JoVE Chemistry A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer (SMPS-ICPMS) Mohamed Tarik1, Debora Foppiano1,2, Adrian Hess1,3, Christian Ludwig1,2 1Bioenergy and Catalysis Laboratory (LBK), Energy and Environment Research Division (ENE), Paul Scherrer Institute, 2Environmental Engineering Institute (IIE), School of Architecture, Civil and Environmental Engineering (ENAC), École; Polytechnique Fédérale de Lausanne (EPFL), 3Institute for Atmospheric and Climate Science ETH Zurich In this work a practical guide is provided, describing the different steps to establish the coupling of SMPS and ICPMS systems, and how to use them. Three descriptive examples are presented.