Gottfried-Wilhelm-Leibniz Universitat Hannover 1 article published in JoVE Bioengineering Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation Tamanna Nagraik1, Alina Gonzalez Salcedo1, Dörte Solle1, Thomas Scheper1 1Institute for Technical Chemistry, Gottfried-Wilhelm-Leibniz Universität Hannover Here, we present a detailed procedure to run a Design of Experiment in an automated micro-bioreactor followed by cell harvest and protein quantification using a Protein A column.