Nordic Bioscience 1 article published in JoVE Biology An Ex Vivo Tissue Culture Model of Cartilage Remodeling in Bovine Knee Explants Christian S. Thudium*1, Amalie Engstrom*1,2, Solveig S. Groen1, Morten A. Karsdal1, Anne-Christine Bay-Jensen1 1Nordic Bioscience, 2Department of Biomedical Sciences, University of Copenhagen Here, we present a protocol describing isolation and culturing of cartilage explants from bovine knees. This method provides an easy and accessible tool to describe tissue changes in response to biological stimuli or novel therapeutics targeting the joint.
