Jesus Uson Minimally Invasive Surgery Centre 1 article published in JoVE Medicine A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery Alberto Ballestín1, Javier G. Casado2, Elena Abellán1, Francisco Javier Vela1, José Luis Campos1, Guadalupe Martínez-Chacón1, Jorge Bote3, Rebeca Blázquez2, Francisco Miguel Sánchez-Margallo1,2,3 1Department of Microsurgery, Jesús Usón Minimally Invasive Surgery Centre, 2Stem Cell Therapy Unit, Jesús Usón Minimally Invasive Surgery Centre, 3Animal Modelling Unit, Jesús Usón Minimally Invasive Surgery Centre Here, we describe a pre-clinical animal model for studying the pathophysiology of ischemia-reperfusion injury in reconstructive microsurgery. This free skin flap model based on the superficial caudal epigastric vessels in the rat may also allow for the evaluation of different therapies and compounds to counteract ischemia-reperfusion injury-related damage.
