INSERM U951 1 article published in JoVE Medicine Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models Jeremie Cosette1,2,3, Rym Ben Abdelwahed2, Sabrina Donnou-Triffault1,4,5, Catherine Sautès-Fridman2, Patrice Flaud*3, Sylvain Fisson*1,4,5 1Genethon, 2Cordeliers Research Center, INSERM U872, 3Matter and Complex Systems Laboratory, Université Paris Diderot, 4INSERM U951, 5UMR_S951, Université d'Evry Val d'Essonne Bioluminescence imaging is a well-known tool for localizing tumors and metastases, but quantification of these images often requires complex calculations and particular instruments. We describe the easy-to-use luminoscore method, based on precise acquisition conditions, requiring no calculations, and enabling tumor burden and treatment response to be monitored in mouse models.
