Paris Cardiovascular Research Centre 1 article published in JoVE Immunology and Infection Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature Keira Melican1,2, Flore Aubey1,2, Guillaume Duménil1,2 1INSERM U970, Paris Cardiovascular Research Centre, 2Faculté de Médecine Paris Descartes, Université Paris Descartes Neisseria meningitidis is a human specific pathogen that infects blood vessels. In this protocol human microvessels are introduced into a mouse by grafting human skin onto immunocompromised mice. Bacteria adhere extensively to the human vessels, leading to vascular damage and development of the purpuric rash typically observed in human cases.
