University of Hull 3 articles published in JoVE Developmental Biology Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair Holly Nicola Wilkinson1, Alexandria Sarah Kidd1, Elizabeth Rose Roberts1, Matthew James Hardman1 1Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, University of Hull Here we demonstrate an optimized technique for assessing wound repair using ex vivo human skin combined with a whole-mount staining approach. This methodology provides a pre-clinical platform for the evaluation of potential wound therapies. Cancer Research How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases Mercedes Rodriguez-Teja1, Claudia Breit2, Mitchell Clarke3, Kamil Talar3, Kai Wang3, Mohammad A. Mohammad3, Sage Pickwell3, Guillermina Etchandy1, Graeme J. Stasiuk3, Justin Sturge3 1Departamento de Genética, Facultad de Medicina, Universidad de la República (UDELAR), 2Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 3School of Biological, Biomedical & Environmental Sciences, University of Hull Here we explain a protocol for modelling the biophysical microenvironment where crosslinking and increased stiffness of the basement membrane (BM) induced by advanced glycation endproducts (AGEs) has pathological relevance. Medicine Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication Natalie Vanicek1,2, Stephanie A. King2, Risha Gohil2,3, Ian C. Chetter3, Patrick A Coughlin3,4 1Discipline of Exercise and Sport Science, Faculty of Health Sciences, University of Sydney, 2Department of Sport, Health and Exercise Science, University of Hull, 3Academic Vascular Department, Hull Royal Infirmary, Hull and East Yorkshire Hospitals, 4 Individuals with intermittent claudication exhibit poor balance compared to healthy controls. Computerized dynamic posturography is an objective method for measuring an individual's postural responses to balance disturbances. This provides an objective reflection of the person’s ability to respond to situations under which sensory stimuli are altered and unexpected perturbations occur.
